Clinical microdose study of gossypol: effect on sperm motility and renal function.
This study is part of a series designed to identify the smallest effective gossypol dose for male fertility control. Three men, aged 31-35 years, were administered gossypol, 10 mg/day, orally for 3 months. Urinalysis and assays for plasma hormone values, including cortisol, beta 2-microglobulin, potassium, and BUN, showed no changes during treatment. Forward sperm motility, however, was severely affected by the end of the treatment period (less than 4% forward motility). Sperm density also showed a marked decrease. The subjects developed no undue side effects.
Frick
J
J
Department of Urology, General Hospital Salzburg, Austria.
Aulitzky
W
W
Kalla
N R
NR
D000328:Adult; D001806:Blood Urea Nitrogen; D003272:Contraceptive Agents, Male / Q000008:administration & dosage* / Q000494:pharmacology; D006072:Gossypol / Q000008:administration & dosage* / Q000494:pharmacology; D006728:Hormones / Q000097:blood; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008297:Male; D011188:Potassium / Q000097:blood; D013081:Sperm Motility / Q000187:drug effects*
D003272:Contraceptive Agents, Male; D006728:Hormones; D006072:Gossypol; D011188:Potassium