Pressure, biochemical, and culture characteristics of CSF associated with the in utero drainage of various fetal CNS defects.
An attempt has been made to begin delineation of the in utero dynamics of fetal intracranial fluid in the presence of brain malformations. In a series of patients with fetal CNS defects, cephalocentesis was performed at the time of therapeutic abortion or to facilitate vaginal delivery. Intracranial CSF pressures and volumes were quite variable. There did not appear to be any discernible correlation between the type of lesion and the intracranial pressure. Fetal CSF glucose levels were moderately depressed and protein concentrations were very high. Neither virus nor bacteria were cultured from fetal CSF or amniotic fluid of any patients in this series.
Simpson
G F
GF
Department of Obstetrics, University of California, San Francisco.
Edwards
M S
MS
Callen
P
P
Filly
R F
RF
Anderson
R L
RL
Golbus
M S
MS
D000653:Amniotic Fluid / Q000032:analysis; D002490:Central Nervous System / Q000002:abnormalities*; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D003616:Dandy-Walker Syndrome / Q000134:cerebrospinal fluid / Q000175:diagnosis; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid / Q000175:diagnosis; D007427:Intracranial Pressure; D011247:Pregnancy; D011296:Prenatal Diagnosis