title: Amphetamine increases intertrial but not conditional instrumental responding in the cortico-basomedial amygdalar dogs.
abstract: The effect of partial cortico-basomedial amygdaloid lesions on dogs' social behavior was investigated. The lesions did not affect the conditional instrumental responding (CRs) reinforced by petting or the dogs' need for petting (US). The lesions increased the number of intertrial responses (ITRs) in all dogs. Subsequently the effect of low amphetamine doses (0.5 mg/l kg) administered intramuscularly to the amygdalar animals on the same behavioral parameters of the social behavior was examined. Amphetamine did not affect CRs but dramatically increased the ITRs and dogs' need for petting. These findings suggest that the cortico-basomedial amygdaloid region may be involved in the cortical inhibitory mechanisms that are indispensable for promoting behavioral acts according to their usefulness and the situational context.
authors: Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland.
authors: E
authors: E
authors: Kostarczyk
authors: E
authors: E
authors: Fonberg
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology*; D004285:Dogs; D008297:Male; D009042:Motivation / Q000502:physiology; D012054:Reinforcement, Psychology; D012919:Social Behavior
chemical_list: D000661:Amphetamine