title: Recurarisation following a suxamethonium-alcuronium sequence in patients with atypical cholinesterase.
abstract: Alcuronium 10 mg was administered to maintain muscle relaxation in two patients before recovery from suxamethonium neuromuscular blockade to facilitate tracheal intubation. This sequence resulted in a markedly prolonged block which could not be antagonised adequately by neostigmine 0.05 mg/kg; initial antagonism was followed rapidly by prolonged recurarisation. Estimation of plasma cholinesterase activity revealed that the two patients were homozygous for the atypical and silent genes. respectively.
authors: Department of Anesthesiology, American University of Beirut, Lebanon.
authors: A
authors: A
authors: Baraka
authors: A N
authors: AN
authors: Sibai
authors: M
authors: M
authors: Hamed
authors: R
authors: R
authors: Delleh
mesh_terms: D000328:Adult; D000443:Alcuronium / Q000008:administration & dosage*; D002802:Cholinesterases / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009388:Neostigmine / Q000494:pharmacology; D011183:Postoperative Complications / Q000209:etiology; D011247:Pregnancy; D011644:Puerperal Disorders / Q000209:etiology; D013390:Succinylcholine / Q000009:adverse effects*; D013997:Time Factors; D014117:Toxiferine / Q000031:analogs & derivatives*
chemical_list: D009388:Neostigmine; D014117:Toxiferine; D002802:Cholinesterases; D013390:Succinylcholine; D000443:Alcuronium