title: Lysophospholipids are natriuretic and diuretic in rats.
abstract: The effects of lysophosphatidylcholine (LPC) and some of its analogues on renal sodium (UNaV) and water excretion (V) were examined in the pentobarbital sodium-anesthetized rat. LPC caused the increase in UNaV and V with a steep dose response. The natriuretic effect began within 20 min after a bolus injection and lasted for 7 h. The natriuresis and diuresis were not affected when the phospholipid was given as an LPC-albumin complex. Natriuretic activity was eliminated by substituting unsaturated bonds in the 1-acyl group and by removing the choline group on position 3. Natriuretic activity was not affected by substitution of 1-alkyl for 1-acyl groups and was stereospecific. These results demonstrate a unique, previously unrecognized effect of lysophospholipids and suggest that they may account for some of the previously demonstrated natriuretic activity of plasma.
authors: Department of Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
authors: A L
authors: AL
authors: Rauch
authors: V M
authors: VM
authors: Buckalew
mesh_terms: D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013329:Structure-Activity Relationship
chemical_list: D008244:Lysophosphatidylcholines