title: Spontaneous intracranial hemorrhage in immune thrombocytopenic purpura.
abstract: Spontaneous intracranial hemorrhage (ICH) is a rare but devastating complication in patients with chronic immune thrombocytopenic purpura (ITP). We report four patients with chronic ITP unresponsive to steroid treatment who developed ICH. One patient had systemic lupus erythematosus; in another patient, the ICH originated from an arteriovenous malformation. High dose steroids, platelet concentrates, emergency splenectomy, and subsequent evacuation of intracranial hematoma, if necessary, can lead to a reasonable outcome of ICH in patients with chronic ITP.
authors: Institute of Hematology, Radiology and Pathology, Rambam Medical Center, Haifa, Israel.
authors: B
authors: B
authors: Brenner
authors: J N
authors: JN
authors: Guilburd
authors: I
authors: I
authors: Tatarsky
authors: Y
authors: Y
authors: Doron
authors: D
authors: D
authors: Goldsher
mesh_terms: D000293:Adolescent; D000328:Adult; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology*; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D011696:Purpura, Thrombocytopenic / Q000150:complications* / Q000276:immunology; D014057:Tomography, X-Ray Computed