Diol lipids are activators of protein kinase C.
Diol lipids (dioleoyl- and dioctanoylethylene glycol) at relatively low concentrations (approximately 10 microM) were found to activate significantly protein kinase C in the presence of phosphatidylserine or phosphatidylinositol. Since diol lipids are widespread minor lipid constituents of many cells [(1974) Chem. Ind., 597-604], it has been suggested that they may be involved in the maintaining of basal protein kinase C activity in the absence of external stimuli.
Severin
S E
SE
M.V. Lomonosov Moscow Institute of Fine Chemical Technology, Academy of Sciences of the USSR.
Tovmasyan
E K
EK
Shvets
V I
VI
Molotkovsky
J G
JG
Bergelson
L D
LD
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives*; D000266:Adenylyl Imidodiphosphate / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D004789:Enzyme Activation / Q000187:drug effects; D005026:Ethylene Glycols / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000494:pharmacology; D010718:Phosphatidylserines / Q000494:pharmacology; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats
D005026:Ethylene Glycols; D010716:Phosphatidylinositols; D010718:Phosphatidylserines; D000266:Adenylyl Imidodiphosphate; C056214:dioctanoyl ethylene glycol; D000255:Adenosine Triphosphate; C056213:dioleoyl ethylene glycol; D011493:Protein Kinase C