A method for recognizing specific effects on ethanol intake by experimental animals.
A method of mathematical treatment of data concerning changes in voluntary consumption of ethanol solution, water and solid food, induced by experimental treatments in animals, in order to recognize effects on mechanisms involved in specific appetite and satiety for calories, water and ethanol is proposed. The need of such method arises from the fact that several experimental treatments tested by the effects on ethanol consumption alter at the same time the appetite or satiety for calories and/or for water, as well as ingestive behavior. The results of testing the method with the data obtained by treatment of UChA and UChB rats with disulfiram or cyanamide were consistent with the expected ones.
Mardones
J
J
Department of Pharmacology, Faculty of Medicine, Universidad de Chile, Santiago.
Contreras
S
S
Segovia-Riquelme
N
N
D000428:Alcohol Drinking / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D003484:Cyanamide / Q000494:pharmacology; D004221:Disulfiram / Q000494:pharmacology; D004327:Drinking Behavior / Q000187:drug effects; D002149:Energy Intake / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000187:drug effects*
D003484:Cyanamide; D004221:Disulfiram