Uncertain effect of indomethacin on physeal growth injury. Experiments in rabbits.
Growth arrest and shortening remain significant sequelae of growth-plate injuries. Nonsteroidal anti-inflammatory agents, known to inhibit callus and bone formation, may be useful to diminish callus-induced growth effects after epiphyseal fracture. In this study, we created a longitudinal osteotomy of the medial distal femoral condyle in 54 rabbits to model a Type IV epiphyseal fracture. We treated half with indomethacin and half with normal saline for 6 weeks. Nineteen animals of each group developed deformity, with indomethacin-treated animals averaging only slightly less angulation than the controls. However, the mean femoral shortening was less in the indomethacin-treated animals as compared with the controls.
Shindell
R
R
Department of Orthopedics and Rehabilitation, University of Nebraska Medical Center, Omaha 68105-1065.
Lippiello
L
L
Connolly
J F
JF
D000818:Animals; D005260:Female; D005264:Femoral Fractures / Q000473:pathology / Q000503:physiopathology*; D006132:Growth Plate / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D007213:Indomethacin / Q000494:pharmacology*; D011817:Rabbits; D000072042:Salter-Harris Fractures; D014945:Wound Healing / Q000187:drug effects
D007213:Indomethacin