title: Penetration of roxithromycin in bronchial secretions.
abstract: Roxithromycin sputum and serum concentrations after administration of therapeutic doses (150 mg in a single dose) were evaluated in six patients. Blood samples and pooled sputum samples were collected at corresponding time intervals up to 24 h after drug administration. Roxithromycin sputum levels were found to be almost always above serum concentrations, the highest sputum levels being 5.85 +/- 2.5 micrograms/ml in the interval ranging from 2 to 4 h after drug administration. Due to its antibacterial spectrum and favourable pharmacokinetic properties, roxithromycin, like other macrolide antibiotics, seems to be particularly indicated in the treatment of respiratory tract infections.
authors: Institute of Respiratory Diseases, University of Pavia, Italy.
authors: V
authors: V
authors: De Rose
authors: A
authors: A
authors: Ferrara
authors: P
authors: P
authors: Mangiarotti
authors: A
authors: A
authors: Nonis
authors: R
authors: R
authors: Bertoletti
authors: G
authors: G
authors: Gialdroni Grassi
mesh_terms: D000367:Age Factors; D000368:Aged; D001980:Bronchi / Q000378:metabolism*; D001991:Bronchitis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007933:Leucomycins / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D013183:Sputum / Q000032:analysis*
chemical_list: D007933:Leucomycins