Naproxen nephrotoxicity in a 2-year-old child.
The development of acute renal failure and interstitial nephritis due to therapeutic doses of nonsteroidal anti-inflammatory drugs has been documented repeatedly in adult patients but is rare in children. We report the occurrence of this complication in a child. Acute renal failure and hyperkalemia developed in a 2-year-old boy with juvenile rheumatoid arthritis after one month of naproxen sodium therapy. The evidence of renal toxic effects became manifest after an episode of dehydration. A percutaneous renal biopsy specimen revealed interstitial nephritis. The patient recovered promptly after withdrawal of the drug.
Ray
P E
PE
Department of Pediatrics, University of California, San Francisco.
Rigolizzo
D
D
Wara
D R
DR
Piel
C F
CF
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D001171:Arthritis, Juvenile / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007672:Kidney Cortex / Q000473:pathology; D008297:Male; D009288:Naproxen / Q000009:adverse effects* / Q000627:therapeutic use; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology
D009288:Naproxen