title: Effects of prednisolone on sex hormone binding globulin during primary endocrine treatment of advanced breast cancer.
abstract: Serum sex hormone binding globulin (SHBG) was measured in 21 pre and 39 postmenopausal women with advanced breast cancer before treatment and 1, 3, 6, 9 and 12 months after ovarian irradiation or during continuous administration of tamoxifen at a dose of 10 mg twice daily, respectively; some patients received additional prednisolone at a dose of 5 mg twice a day. Ovarian irradiation was associated with a 25% reduction in serum SHBG levels 3 to 6 months after treatment whilst patients on tamoxifen experienced a rise of about 80% in serum SHBG levels after 1 to 3 months. In postmenopausal women prednisolone markedly dampened the effect of tamoxifen, reducing a 80% rise to about 20%. There was no relationship between SHBG levels and response to treatment.
authors: Imperial Cancer Research Fund, London, United Kingdom.
authors: D Y
authors: DY
authors: Wang
authors: R D
authors: RD
authors: Rubens
authors: G M
authors: GM
authors: Clark
authors: J W
authors: JW
authors: Moore
authors: R D
authors: RD
authors: Bulbrook
mesh_terms: D001943:Breast Neoplasms / Q000097:blood / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008593:Menopause; D010053:Ovary / Q000528:radiation effects; D011239:Prednisolone / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013629:Tamoxifen / Q000627:therapeutic use*
chemical_list: D012738:Sex Hormone-Binding Globulin; D013629:Tamoxifen; D011239:Prednisolone