title: A survey of malformed aborted bovine fetuses, stillbirths and nonviable neonates for abnormal karyotypes.
abstract: Postmortem examinations were performed on 30 morphologically abnormal aborted bovine fetuses, stillbirths and nonviable neonates. Fibroblasts from the pericardium were cultured for chromosome analysis. Karyotypes were successfully completed on 18 animals, of which three were trisomic, one was mosaic monosomic and one was chimeric. All aneuploid calves had multisystemic anomalies. Using chromosomal banding techniques, the abnormal karyotypes were determined to be: 61,XY,+27; 61,XX,+21; 61,XY,+?; 59,XY,-?/60,XY; and 60,XX/60,XY. Bacterial contamination or nonviability of tissues prevented the growth of fibroblasts in culture and cytogenetic analysis of the other 12 animals. It was estimated that 2.0% of all late gestation abortuses and stillbirths may have chromosomal abnormalities characterized by aneuploidy. The findings of this study suggest chromosomal abnormalities characterized by aneuploidy are a significant cause of multisystemic anomalies in aborted bovine fetuses and nonviable neonates.
authors: Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon.
authors: J W
authors: JW
authors: Coates
authors: S M
authors: SM
authors: Schmutz
authors: C G
authors: CG
authors: Rousseaux
mesh_terms: D000034:Abortion, Veterinary / Q000235:genetics / Q000473:pathology*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations / Q000662:veterinary*; D025063:Chromosome Disorders; D005260:Female; D005313:Fetal Death / Q000473:pathology / Q000662:veterinary*; D005333:Fetus / Q000473:pathology*; D007621:Karyotyping / Q000662:veterinary; D011247:Pregnancy