title: Pharmacokinetics of high and moderate intravenous doses of methotrexate.
abstract: The pharmacokinetic parameters of methotrexate in nine cancer patients receiving 250-2500 mg/day were investigated. Both elimination rate constants and half-lives were calculated using a two-compartmental open model. The plasma levels-time profiles revealed a biphasic response with a mean initial elimination half-life of 2.3 +/- 0.2 hours and a terminal elimination half-life of 32.2 +/- 7.2 hours.
authors: Faculty of Medicine, University of Jordan, Amman.
authors: A
authors: A
authors: Awidi
authors: A
authors: A
authors: al-Turk
authors: F
authors: F
authors: Madanat
authors: S
authors: S
authors: Othman
authors: O
authors: O
authors: Shaheen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008727:Methotrexate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008875:Middle Aged; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism
chemical_list: D008727:Methotrexate