The different contributions of coronary blood flow to changes in myocardial oxygen consumption between excised and in situ canine hearts.
The correlations of CBF-MVO2 and AVD-MVO2 were analyzed by linear regression analysis in three groups of canine heart preparations. CBF correlated well with MVO2 in all cases of in situ heart preparations, and the sensitivity of CBF to changes in MVO2 was high. In contrast, AVD, rather than CBF, correlated well with MVO2 in all cases of excised hearts, and the sensitivity of CBF to changes in MVO2 was low. The different manner of oxygen delivery in excised hearts from that in situ hearts can be attributed to the characteristics of its coronary perfusion and the impaired mechanism of metabolic vasoregulation in the coronary vasculature.
Futaki
S
S
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka, Japan.
Nozawa
T
T
Yasumura
Y
Y
Tanaka
N
N
Uenishi
M
M
Suga
H
H
D000818:Animals; D003326:Coronary Circulation; D004285:Dogs; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D014655:Vascular Resistance
D010100:Oxygen