Sequence of drug administration in lithium augmentation: a case study.
A 25-year-old man was hospitalized twice for melancholia. During the first hospitalization he had no response to a trial of desipramine but improved after the addition of lithium; during the second hospitalization he had no response to lithium but improved after the addition of desipramine. Concurrent administration of lithium and a tricyclic may be effective in some patients who respond to neither drug alone, but the sequence of drug administration may not be a critical factor.
Price
L H
LH
Department of Psychiatry, Yale University School of Medicine, New Haven, CT.
Delgado
P L
PL
Charney
D S
DS
Heninger
G R
GR
D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D003891:Desipramine / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D011569:Psychiatric Status Rating Scales
D008094:Lithium; D003891:Desipramine