Familial multiple sclerosis.
Siblings of patients with multiple sclerosis have an increased risk of developing the disease. In this report we describe 3 families with multiple affected members, representing the largest published aggregation of cases in first degree relatives. In the 2 families in which HLA tissue-typing was performed the affected individuals shared part of the haplotype HLA-DR2 (+ HLA-DQW1), BfS (+ C2C), C4A3, C4B1. The implications of these findings for the aetiology of multiple sclerosis are discussed.
Hartung
H P
HP
Department of Neurology, University of Düsseldorf, F.R.G.
Will
R G
RG
Francis
D
D
Grosse-Wilde
H
H
Rudge
P
P
Scaravilli
F
F
Hennerici
M
M
McDonald
W I
WI
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology; D005260:Female; D006680:HLA Antigens; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D010375:Pedigree
D006680:HLA Antigens