title: Reductions in [3H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: an autoradiographic study.
abstract: In Alzheimer's disease (AD) and Parkinson's disease (PD), dysfunction in the basal forebrain cholinergic system is accompanied by a consistent loss of presynaptic cholinergic markers in cortex, but changes in cholinergic receptor binding sites are poorly understood. In the present study, we used receptor autoradiography to map the distribution of nicotinic [3H]acetylcholine binding sites in cortices of individuals with AD and PD and matched control subjects. In both diseases, a profound loss of nicotinic receptors occurs in all cortical layers, particularly the deepest layers.
authors: Department of Neurology, Case Western Reserve University, Cleveland, OH.
authors: P J
authors: PJ
authors: Whitehouse
authors: A M
authors: AM
authors: Martino
authors: M V
authors: MV
authors: Wagster
authors: D L
authors: DL
authors: Price
authors: R
authors: R
authors: Mayeux
authors: J R
authors: JR
authors: Atack
authors: K J
authors: KJ
authors: Kellar
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism*; D001345:Autoradiography; D002540:Cerebral Cortex / Q000378:metabolism; D005625:Frontal Lobe / Q000378:metabolism; D006801:Humans; D010300:Parkinson Disease / Q000378:metabolism*; D011180:Postmortem Changes; D011978:Receptors, Nicotinic / Q000378:metabolism*; D014316:Tritium
chemical_list: D011978:Receptors, Nicotinic; D014316:Tritium