title: A chronic toxicity/carcinogenicity study of FD & C Yellow No. 5 (tartrazine) in mice.
abstract: Charles River CD-1 mice were fed FD & C Yellow No. 5 in the diet at levels of 0.0, 0.0, 0.5, 1.5 or 5.0% in a long-term toxicity/carcinogenicity study. Each group consisted of 60 males and 60 females. Maximum exposure was 104 wk for both males and females. No consistent, significant compound-related adverse effects were noted. The no-observed-adverse effect level established in this study was 5.0% (8103 mg/kg/day and 9735 mg/kg/day for male and female mice, respectively.)
authors: Medical College of Virginia, Department of Pharmacology and Toxicology, Richmond 23298.
authors: J F
authors: JF
authors: Borzelleca
authors: J B
authors: JB
authors: Hallagan
mesh_terms: D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D013645:Tartrazine / Q000633:toxicity*; D013997:Time Factors
chemical_list: D001391:Azo Compounds; D002273:Carcinogens; D013645:Tartrazine