Serum myoglobin release following suxamethonium administration to children.
Serum myoglobin was measured in 40 children (mean age 5 yrs) following suxamethonium administration during anaesthesia for tonsillectomy. Half were given an i.v. induction while half were given an inhalation induction. Pre-treatment with alcuronium 0.04 mg kg-1 prior to suxamethonium administration was given to half the patients in each group. Mean pre-induction serum myoglobin was 11.8 micrograms litre-1. Following i.v. induction there was a marked rise of serum myoglobin in the control subgroup to a mean of 113 micrograms litre-1 20 min after suxamethonium administration. There was no such rise in the pre-treatment subgroup. In the inhalation control subgroup, there was a much larger mean rise to 537 micrograms litre-1 (significantly greater than in the control IV group), one patient reaching 2800 micrograms litre-1 20 min after suxamethonium administration. Pre-treatment greatly reduced but did not totally prevent the rise following inhalation induction.
Laurence
A S
AS
Department of Anaesthetics, Royal Preston Hospital, United Kingdom.
D000443:Alcuronium / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009211:Myoglobin / Q000378:metabolism*; D013390:Succinylcholine / Q000494:pharmacology*
D009211:Myoglobin; D013390:Succinylcholine; D000443:Alcuronium