title: [Crystal modifications of 3-cyan-6-methyl-5-(pyrid-4-yl)-1,2-dihydropyrid-2-one (milrinone)].
abstract: The preparation and characterisation of crystalline alpha-, beta- and gamma modifications of 3-cyan-6-methyl-5-(4-pyrid-4-yl)-1,2-dihydropyrid-2-on e are described. The thermic transformation of alpha- and beta-modification into gamma-modification was proved by thermogravimetric analysis (t.g.a.), differential scanning calorimetry (d.s.c.), IR and powder diffraction pattern. In dissolution behaviour no significant differences were found between the modifications.
authors: Akademie der Wissenschaften der DDR, Institut für Wirkstofforschung, Berlin.
authors: E
authors: E
authors: Klauschenz
authors: V
authors: V
authors: Hagen
authors: B
authors: B
authors: Gentsch
authors: H
authors: H
authors: Niedrich
authors: M
authors: M
authors: Dathe
authors: G
authors: G
authors: Reck
authors: H J
authors: HJ
authors: Jänsch
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D020105:Milrinone; D011728:Pyridones / Q000032:analysis*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
chemical_list: D011728:Pyridones; D020105:Milrinone
vernacular_title: Kristallmodifikationen von 3-Cyan-6-methyl-5-(pyrid-4-yl)-1,2-dihydropyrid-2-on (Milrinon).