The borderline hypertensive rat: a model for studying the mechanisms of environmentally induced hypertension.
The borderline hypertensive rat (BHR) is a first-generation cross between the spontaneously hypertensive rat and the normotensive Wistar-Kyoto rat. The BHR develops frank hypertension when chronically stressed or when fed a high-sodium diet. Stress-induced hypertension can be blocked by exercise. The role of the central nervous system and kidney in hypertension development in this model is discussed.
Lawler
J E
JE
Department of Psychology, University of Tennessee, Knoxville 37996-0900.
Cox
R H
RH
Sanders
B J
BJ
Mitchell
V P
VP
D000818:Animals; D001933:Brain Stem / Q000032:analysis; D004195:Disease Models, Animal; D006973:Hypertension / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D007031:Hypothalamus / Q000032:analysis; D007668:Kidney / Q000503:physiopathology; D008297:Male; D009638:Norepinephrine / Q000032:analysis; D005082:Physical Exertion; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D012964:Sodium / Q000009:adverse effects; D013312:Stress, Physiological / Q000150:complications
D012964:Sodium; D009638:Norepinephrine