title: Colchicine therapy of the renal amyloidosis of ulcerative colitis.
abstract: Two patients with severe proteinuria, due to renal amyloidosis complicating chronic ulcerative colitis, improved remarkably with colchicine therapy. One patient with an initial daily urine protein excretion of 13.70 g had a reduction within 2 mo to 6.50 g and to 0.37 g after 9 yr. The other patient's daily urine protein excretion was 9.00 g. This was reduced to 5.10 g/day within 3 mo and was 0.53 g/day by 8 mo. Renal function remained stable or improved during the period of therapy. Colchicine resulted in rapid and prolonged benefit for these patients, despite their amyloid-induced nephrotic syndrome.
authors: Department of Medicine, Mount Sinai School of Medicine, City University of New York, New York.
authors: S
authors: S
authors: Meyers
authors: H D
authors: HD
authors: Janowitz
authors: V V
authors: VV
authors: Gumaste
authors: R G
authors: RG
authors: Abramson
authors: L J
authors: LJ
authors: Berman
authors: V S
authors: VS
authors: Venkataseshan
authors: S H
authors: SH
authors: Dickman
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000150:complications / Q000188:drug therapy*; D003078:Colchicine / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000150:complications*; D005260:Female; D006801:Humans; D011507:Proteinuria / Q000209:etiology*
chemical_list: D003078:Colchicine