Multiple parameter analyses of human ovarian cancer: morphology, immunohistochemistry, steroid hormone receptors and aromatase.
All human ovarian tumors (n = 32) analysed were positive for cytokeratin except for a single case. OV-TL 3 stained 96% (26/27) and 1 out of 4 controls, while OC-125 stained 86% (24/27) and 3 out of 4 non-ovarian carcinomas. Androgen receptors predominated (AR-96%) compared to estrogen (ER-32%) or progestin (PgR-50%) receptors in the ovarian carcinomas. Aromatase activity was detected in 6 ovarian carcinomas and in 3 non-ovarian carcinomas. No definite relationship was observed between the parameters measured. Ovarian carcinomas stained brightly with OV-TL 3 and OC-125 had high AR levels, while focal or absent reaction was related to low AR levels. A role for androgens in ovarian cancer is suggested.
Kühnel
R
R
Department of Endocrinology, Vrije Universiteit, Amsterdam, The Netherlands.
Rao
B R
BR
Poels
L G
LG
Delemarre
J F
JF
Kenemans
P
P
Stolk
J G
JG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001141:Aromatase / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000032:analysis* / Q000473:pathology; D011944:Receptors, Androgen / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D011987:Receptors, Steroid / Q000032:analysis*
D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid; D001141:Aromatase