Developmental expression of proenkephalin mRNA in rat striatum and in striatal cultures.
Proenkephalin mRNA shows a biphasic developmental profile in rat striatum, with an initial peak at postnatal day 2, a decline to embryonic levels by day 7, and a second increase to adult levels over the course of the second to 4th week after birth. The same 4-fold increase is seen in cultured striatal neurons, over the same time course but without a biphasic response. Cultured fetal glia also contain proenkephalin mRNA.
Schwartz
J P
JP
Clinical Neuroscience Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
Simantov
R
R
D000367:Age Factors; D000375:Aging / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D003342:Corpus Striatum / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D004745:Enkephalins / Q000235:genetics* / Q000502:physiology; D005786:Gene Expression Regulation; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D011498:Protein Precursors / Q000235:genetics* / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D004745:Enkephalins; D005904:Glial Fibrillary Acidic Protein; D011498:Protein Precursors; D012333:RNA, Messenger; C029992:proenkephalin