Is the magnetic resonance imaging proton spin-lattice relaxation time a reliable noninvasive parameter of developing liver fibrosis?
During the development of liver fibrosis in rats by an individual dose-titrated CCl4 administration, hepatic proton spin-lattice relaxation time (T1) has been measured in vivo every 2 weeks for 8 weeks. Liver content of collagen, triglycerides and water has been measured biochemically in biopsy material. After 4 weeks of CCl4 treatment, T1 increased significantly and remained at the same level, whereas liver collagen reached its maximum at 8 weeks. It is concluded that, under our experimental conditions, increased hepatic T1 represents drug-induced edema and that hepatic T1 is not a reliable noninvasive parameter for developing liver fibrosis in vivo.
Chamuleau
R A
RA
Laboratory of Experimental Medicine, University of Amsterdam, The Netherlands.
Creyghton
J H
JH
De Nie
I
I
Moerland
M A
MA
Van der Lende
O R
OR
Smidt
J
J
D000818:Animals; D002251:Carbon Tetrachloride; D006909:Hydroxyproline / Q000378:metabolism; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
D014280:Triglycerides; D002251:Carbon Tetrachloride; D006909:Hydroxyproline