title: The elimination of spermidine from plasma in rats.
abstract: Infused spermidine in rats with bypassed livers was eliminated very slowly, whereas endogenous spermidine in saline-infused controls with bypassed livers increased. In the same animals endogenous putrescine plasma levels did not differ significantly between spermidine- or saline-infused animals, whereas endogenous cadaverine levels increased during spermidine infusion and decreased afterwards. It is concluded that the liver is the most important site for plasma spermidine elimination.
authors: Dept. of Pharmacology, University of Leiden, The Netherlands.
authors: A
authors: A
authors: Emonds
authors: M
authors: M
authors: van de Ven
authors: J
authors: J
authors: Hermans
authors: O
authors: O
authors: Driessen
mesh_terms: D000818:Animals; D002103:Cadaverine / Q000097:blood; D005260:Female; D006207:Half-Life; D007262:Infusions, Intravenous; D008099:Liver / Q000378:metabolism; D011700:Putrescine / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013095:Spermidine / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D002103:Cadaverine; D013095:Spermidine; D011700:Putrescine