Identification of biliprotein as a liver growth factor.
We determined the concentration of biliprotein in plasma of rats at different times after partial hepatectomy. From the same plasma samples, we purified a liver growth factor previously characterized by our group. When we plotted the 14 points studied, a linear relationship was obtained (r = 0.999; p less than 0.001). This result, in addition to our group's recent identification of this liver growth factor as an albumin-bilirubin complex, strongly suggests that biliprotein is a liver growth factor.
Díaz-Gil
J J
JJ
Department of Experimental Biochemistry, Clínica Puerta de Hierro, Madrid, Spain.
Sánchez
G
G
Trilla
C
C
Escartín
P
P
D000818:Animals; D001663:Bilirubin / Q000097:blood* / Q000302:isolation & purification / Q000494:pharmacology; D002852:Chromatography, Ion Exchange; D006133:Growth Substances / Q000097:blood* / Q000302:isolation & purification / Q000494:pharmacology; D006498:Hepatectomy; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000032:analysis* / Q000097:blood* / Q000302:isolation & purification / Q000494:pharmacology; D000075462:Serum Albumin, Human
D006133:Growth Substances; D012709:Serum Albumin; C053498:albumin-bilirubin complex; D001663:Bilirubin; D000075462:Serum Albumin, Human