title: Effect of flurithromycin, a new macrolide antibiotic, on carbamazepine disposition in normal subjects.
abstract: The effects of flurithromycin, a new macrolide antibiotic, on the disposition of a single oral dose of carbamazepine (CBZ) (400 mg) were investigated in seven normal subjects. Flurithromycin (2 x 250 mg thrice daily for 10 days) caused a slight increase in the CBZ area under the serum concentration curve and a moderate reduction in carbamazepine-10, 11-epoxide (CBZ-E) levels. These results suggest that flurithromycin can inhibit the conversion of CBZ to CBZ-E, although, at the dosage tested, the magnitude of this effect was significantly smaller than that observed after administration of erythromycin in the same subjects.
authors: Department of Internal Medicine and Therapeutics, University of Pavia, Italy.
authors: N
authors: N
authors: Barzaghi
authors: G
authors: G
authors: Gatti
authors: F
authors: F
authors: Crema
authors: A
authors: A
authors: Faja
authors: M
authors: M
authors: Monteleone
authors: C
authors: C
authors: Amione
authors: L
authors: L
authors: Leone
authors: E
authors: E
authors: Perucca
mesh_terms: D000328:Adult; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D008297:Male
chemical_list: D002220:Carbamazepine; C045925:flurithromycin; D004917:Erythromycin; C012227:carbamazepine epoxide