[Hypothalamic insufficiency following irradiation. Late, subacute and curable dementia].
A 31 year-old patient suffered from a subacute and major dementia, sixty months after whole brain irradiation with 54 grays for a pinealoma. Clinical features and biological investigations led to a diagnosis of hypothalamic insufficiency. A dramatic clinical recovery followed therapy with hydrocortisone and thyroxine. An hypothalamic radionecrosis and a vascular mechanism are presumed.
Nighoghossian
N
N
Service de Neurologie, Hôpital Neurologique, Lyon.
Confavreux
C
C
Sassolas
G
G
Boisson
D
D
Vighetto
A
A
Aimard
G
G
Trillet
M
M
D000328:Adult; D001932:Brain Neoplasms / Q000532:radiotherapy*; D003704:Dementia / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007027:Hypothalamic Diseases / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D007031:Hypothalamus / Q000528:radiation effects*; D008297:Male; D010870:Pineal Gland
Insuffisance hypothalamique après irradiation. Démence tardive, subaiguë et curable.