[Use of the data of quantitative analysis of organo-systemic distribution of tumors in the evaluation of real hazards of chemical carcinogens].
The study was concerned with objective criteria for identification of actual carcinogenic hazards. It used quantitative analysis data on morphologic structures of tumors induced in 12565 albino noninbred rats in the course of carcinogenicity evaluation of 112 chemical agents. The totality of all the data were analyzed versus morphologic parameters of tumors and carcinogenicity of the agents. Spontaneous tumors turned to be the cause of death in animals treated with noncarcinogenic or slightly carcinogenic agents whereas a completely different spectrum of tumors were responsible for lethality in those receiving potent carcinogens. It was inferred that increased incidence of spontaneous tumors following treatment with maximum tolerable doses can not be used as a criterion of actual blastogenicity of an agent.
Kurliandskiĭ
B A
BA
Nevzorova
N I
NI
D000310:Adrenal Gland Neoplasms / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens / Q000145:classification / Q000633:toxicity*; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000139:chemically induced; D051381:Rats; D012468:Salivary Gland Neoplasms / Q000139:chemically induced; D012513:Sarcoma, Experimental / Q000139:chemically induced; D013964:Thyroid Neoplasms / Q000139:chemically induced
D002273:Carcinogens
Ispol'zovanie rezul'tatov kolichestvennogo analiza organosistemnogo raspredeleniia opukholeĭ dlia otsenki real'noĭ opasnosti khimicheskikh kantserogenov.