title: Mononuclear cells from rheumatoid arthritis patients exhibit a depressed IgM response to sheep erythrocyte stimulation in vitro.
abstract: Human peripheral blood mononuclear cells when cultured for the short term (11 days) produce an optimal IgM plaque-forming cell (PFC) response to sheep erythrocytes, which is dependent on macrophages and T suppressor and helper lymphocytes. With this system we have investigated the PFC response of individuals with rheumatoid arthritis and compared this to the response of normal sex- and age-matched controls and of patients with osteoarthritis. The response of rheumatoid arthritis patients was significantly lower than that of subjects in the other two categories.
authors: Department of Pathology, Medical University of South Carolina, Charleston 29425.
authors: A
authors: A
authors: Gabrielli
authors: R
authors: R
authors: Silver
authors: G
authors: G
authors: Teti
authors: M S
authors: MS
authors: Chiofalo
authors: A
authors: A
authors: Misefari
authors: D
authors: D
authors: Venza-Teti
authors: G
authors: G
authors: Virella
authors: M F
authors: MF
authors: La Via
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis*; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D012756:Sheep
chemical_list: D007075:Immunoglobulin M