title: SF2446, new benzo[a]naphthacene quinone antibiotics. II. The structural elucidation.
abstract: Structures of new antibiotics SF2446A1, A2, A3, B1, B2 and B3 have been deduced by means of spectral analyses and chemical studies. The structure of SF2446A1 which is a main product of fermentation and has the strongest antimicrobial activity, has been proposed to be 11-(2,4-di-O-methyl-beta-L-rhamnopyranosyl)amino-5,6,6a,14a-tetrah ydro- 1,6,8,14a-tetrahydroxy-6a-methoxy-2-methoxycarbonyl-3-methyl- benzo[a]naphthacene-7,9,12,14-tetra-one. All of antibiotics have a novel benzo[a]naphthacene quinone skeleton and SF2446A1, A2, B1 and B2 have an N-glycosidic linkage with 2,4-di-O-methyl-L-rhamnose.
authors: Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
authors: S
authors: S
authors: Gomi
authors: T
authors: T
authors: Sasaki
authors: J
authors: J
authors: Itoh
authors: M
authors: M
authors: Sezaki
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D055598:Chemical Phenomena; D002621:Chemistry; D008968:Molecular Conformation; D009279:Naphthacenes
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D009279:Naphthacenes; C056021:SF 2446A1; C056023:SF 2446A3; C056024:SF 2446B1; C056022:SF 2446A2; C056025:SF 2446B2