title: Heterogeneity and recurrence risk for congenital hydrocephalus (ventriculomegaly): a prospective study.
abstract: We report on 261 prospectively ascertained pregnancies studied to determine the recurrence risk of congenital hydrocephalus. Our results suggest that couples who have had one previous child with hydrocephalus have a recurrence risk of 4%. Such couples should be offered prenatal diagnosis in the second trimester of all subsequent pregnancies. It is suggested that, apart from the X-linked recessive cases, ventriculomegaly is mostly multifactorially determined.
authors: Department of Pediatrics, University Medical School of Debrecen, Hungary.
authors: V
authors: V
authors: Váradi
authors: Z
authors: Z
authors: Tóth
authors: O
authors: O
authors: Török
authors: Z
authors: Z
authors: Papp
mesh_terms: D005817:Genetic Counseling; D006801:Humans; D006849:Hydrocephalus / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D009436:Neural Tube Defects / Q000150:complications / Q000235:genetics; D011296:Prenatal Diagnosis; D011446:Prospective Studies; D014960:X Chromosome