title: Effect of dietary selenium on the development of Fusarium-induced tibial dyschondroplasia in broiler chickens.
abstract: A trial was conducted to determine the effects of dietary level of selenium on the pathogenesis of Fusarium-induced tibial dyschondroplasia (FITD) in broiler chicks, and to assess the applicability of FITD as an animal model of Kashin-Beck disease of humans. Day-old female broilers were fed diets that were deficient in selenium (0.02 ppm Se), adequate in selenium (0.15 ppm Se), or generous in selenium (0.50 ppm Se). TDP-1, the toxic component of the fungus, was administered to 15 of 26 chicks in each dietary group starting at 1 week of age and continuing until the chicks were killed at 24-30 days of age. Plasma selenium levels and hepatic glutathione peroxidase activity were significantly lower in the selenium-deficient group than in other dietary groups; these parameters were not affected by treatment with TDP-1. The mortality rate of the TDP-1-treated selenium-generous group was significantly less than that in the other TDP-1-treated groups, but there were no differences in the incidence, severity, or character of the FITD lesions among the groups. Thus, the interaction of selenium and TDP-1 did not include an effect on FITD.
authors: Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St. Paul 55108.
authors: M M
authors: MM
authors: Walser
authors: V C
authors: VC
authors: Morris
authors: O A
authors: OA
authors: Levander
mesh_terms: D000596:Amino Acids; D000818:Animals; D002645:Chickens / Q000382:microbiology*; D002867:Chromones; D004195:Disease Models, Animal; D005260:Female; D005670:Fusarium; D009183:Mycotoxins / Q000633:toxicity*; D010009:Osteochondrodysplasias / Q000139:chemically induced / Q000378:metabolism / Q000662:veterinary*; D011201:Poultry Diseases / Q000139:chemically induced* / Q000378:metabolism; D012643:Selenium / Q000172:deficiency / Q000378:metabolism*; D013977:Tibia / Q000473:pathology*
chemical_list: D000596:Amino Acids; D002867:Chromones; D009183:Mycotoxins; C054523:fusarochromanone; D012643:Selenium