title: In vitro metabolism of trenbolone: study of the formation of covalently bound residues.
abstract: In order to study the formation of bound residues of trenbolone, in vitro experiments were performed using bovine liver microsomes. These experiments showed that hepatic mono-oxygenases can generate reactive metabolites, which are able to bind to microsomal proteins or can be detoxified by conjugation to glutathione or to glutathione-S-transferases. Bioavailability and toxicological properties of these adducts are discussed.
authors: Université de Liège, Faculté de médecine vétérinaire, Analyse des denrées alimentaires d'origine animale, Brussels, Belgium.
authors: P
authors: P
authors: Evrard
authors: G
authors: G
authors: Maghuin-Rogister
mesh_terms: D000818:Animals; D002417:Cattle; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000378:metabolism*; D004963:Estrenes / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D014204:Trenbolone Acetate / Q000378:metabolism*
chemical_list: D004963:Estrenes; D005982:Glutathione Transferase; D005978:Glutathione; D014204:Trenbolone Acetate