Evidence for the clonal nature of hypereosinophilic syndrome.
Hypereosinophilic syndrome (HES) is a disease process of unknown pathogenesis. Although some cases are believed to be primary hematologic malignancies, this issue remains unsolved. We present a case of HES in whom we have observed a clone of cytogenetically abnormal cells in the bone marrow in parallel with a clinical picture of a hematologic disorder characterized by progressive proliferation and organ infiltration by eosinophils. The cytogenetic abnormality 46,XY,t(7;12)(q11;p11) is previously unreported. Our case, plus other evidence present in the literature, supports the concept that HES is a hematologic malignant neoplasia.
da Silva
M A
MA
Department of Medicine, Genetics, Indiana University School of Medicine, Indianapolis 46223.
Heerema
N
N
Schwenk
G R
GR
Hoffman
R
R
D000328:Adult; D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D004802:Eosinophilia / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D013577:Syndrome