Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts.
The antitumour activity of flavone acetic acid (FAA) was evaluated against two human colorectal carcinoma (HCC) lines, HCC-P2988 and HCC-M1410, transplanted into nude mice. On repeated i.v. injection of 200 mg kg-1 every 4 days FAA was moderately active against the s.c. growing HCC-P2988. HCC-M1410 transplanted s.c. was almost unresponsive in the same experimental conditions. In contrast, FAA (200 mg kg-1 i.v. every 4 days, repeated three times) significantly reduced liver tumour colonies produced by the HCC-M1410 cells injected intrasplenically into nude mice. These findings suggest that FAA has potential activity against human colorectal carcinoma, particularly against liver metastases.
Giavazzi
R
R
Mario Negri Institute for Pharmacological Research, Bergamo, Italy.
Garofalo
A
A
Damia
G
G
Garattini
S
S
D'Incalci
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D012004:Rectal Neoplasms / Q000188:drug therapy*; D014183:Transplantation, Heterologous
D000970:Antineoplastic Agents; D005419:Flavonoids; C049328:flavone acetic acid