Effect of soybean feeding on experimental carcinogenesis--III. Carcinogenecity of nitrite and dibutylamine in mice: a histopathological study.
The potential carcinogenic effect of nitrosamine precursors, DBA (dibutylamine) and nitrite, was clearly demonstrated pathologically in the liver and bladder of male Swiss albino mice. Benign tumours were induced in the bladder with an incidence of 40%, and hepatomas were detected in the liver in 27% of the cases. The protective effect of soybean and ascorbic acid, added separately to the diet or to the drinking water respectively, was demonstrated by a marked reduction in dysplastic features and absence of tumour in both the liver and the urinary bladder.
Mokhtar
N M
NM
Department of Pathology, National Cancer Institute, University of Cairo, Egypt.
el-Aaser
A A
AA
el-Bolkainy
M N
MN
Ibrahim
H A
HA
Badr El-Din
N K
NK
Moharram
N Z
NZ
D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use; D002082:Butylamines / Q000633:toxicity*; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009573:Nitrites / Q000633:toxicity*; D012977:Sodium Nitrite / Q000633:toxicity*; D013025:Glycine max; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D002082:Butylamines; D009573:Nitrites; C045274:dibutylamine; D012977:Sodium Nitrite; D001205:Ascorbic Acid