title: Limits of cardiac compensation in anemic baboons.
abstract: The risk of homologous blood may cause physicians to withhold red cell treatment after acute blood loss. We believe that in the euvolemic patient with acute anemia, the heart is the principal organ at risk. The cardiac compensation to extreme anemia is unknown and is the purpose of this report. Fourteen adult baboons were anesthetized, paralyzed, and ventilated with room air. Left atrial and coronary sinus catheters were inserted surgically. Experimental animals (n = 7) were hemodiluted at constant left atrial pressure with 5% human serum albumin. Control animals (n = 7) underwent similar volume exchanges with fresh, cross-matched, homologous red blood cells resuspended in human serum albumin, also at constant left atrial pressure. Six of seven experimental animals survived until hematocrit levels were 4%. Adequate cardiac compensation was observed until hematocrit levels were less than 10%. Increased flow, without increases in the O2 extraction ratio, was the mechanism of compensation used by the healthy heart with patent coronary vessels.
authors: Department of Surgery, Michael Reese Hospital and Medical Center, Chicago, IL 60616.
authors: D K
authors: DK
authors: Wilkerson
authors: A L
authors: AL
authors: Rosen
authors: L R
authors: LR
authors: Sehgal
authors: S A
authors: SA
authors: Gould
authors: H L
authors: HL
authors: Sehgal
authors: G S
authors: GS
authors: Moss
mesh_terms: D000222:Adaptation, Physiological; D000740:Anemia / Q000097:blood / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D000818:Animals; D001803:Blood Transfusion; D002302:Cardiac Output; D005078:Exchange Transfusion, Whole Blood; D006321:Heart / Q000503:physiopathology*; D006400:Hematocrit; D007773:Lactates / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D010215:Papio; D012709:Serum Albumin / Q000008:administration & dosage; D014655:Vascular Resistance
chemical_list: D007773:Lactates; D012709:Serum Albumin; D010100:Oxygen