Effect of influenza virus infection on allergic sensitization to inhaled antigen in mice.
Repeated exposure of healthy mice to an aerosol of ovalbumin (OA) leads to the development of IgE-isotype-specific immunological tolerance. However, when initial OA exposure occurs during the acute phase of influenza infection, tolerance does not occur, and the mice instead develop high titres of OA-specific IgE in response to subsequent challenge with the allergen.
Holt
P G
PG
Clinical Immunology Research Unit, Princess Margaret Hospital for Children, Subiaco, Australia.
Vines
J
J
Bilyk
N
N
D000280:Administration, Inhalation; D000485:Allergens / Q000008:administration & dosage* / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D004306:Dose-Response Relationship, Immunologic; D007114:Immunization; D007073:Immunoglobulin E / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007928:Lethal Dose 50; D051379:Mice; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000276:immunology*
D000485:Allergens; D007074:Immunoglobulin G; D007073:Immunoglobulin E