title: [The dose-effect relationship in connection with the study of the interaction of chemical carcinogens].
abstract: Problems arising in studies of the co-action of carcinogenic chemicals may be approached using mathematical models of dose-response dependence. It is shown that approximation of the dose-response dependence of chemical carcinogenesis co-factors can be obtained with the aid of a second-order polynomial. The planning of relevant experiments and studies of dose-response dependence models should be based on application of mathematical planning procedures, namely, second-order plans. Certain plans are recommended.
authors: Iu N
authors: IuN
authors: Katul'skiĭ
mesh_terms: D000818:Animals; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008433:Mathematics; D008954:Models, Biological; D012107:Research Design
chemical_list: D002273:Carcinogens
vernacular_title: O zavisimosti "doza-éffekt" v sviazi s izucheniem sovmestnogo deĭstviia khimicheskikh kantserogenov.