title: Influence of partial replacement of starch by sucrose in high fat-cholesterol diet on serum lipoprotein responses of cynomolgus monkeys.
abstract: The influence of partial replacement of starch by sucrose on dietary cholesterol-induced serum lipoprotein responses was examined in 10 male cynomolgus monkeys (Macaca fascicularis). In a crossover design two semipurified diets provided either starch or starch and sucrose (1:1) as carbohydrate (49% by calories) with 0.4 mg cholesterol/kcal. Six weeks of starch + sucrose diet resulted in significantly reduced levels (mean +/- SE, mg/dl) of serum total cholesterol (264 +/- 9 vs 244 +/- 8) and apo B (110 +/- 6 vs 96 +/- 6) when compared with starch diet, whereas serum triglyceride levels remained similar between diets. With respect to changes in lipids and apolipoproteins (A-I or B) of very low (VLDL), low (LDL), intermediate (IDL), and high (HDL) density lipoproteins, starch + sucrose diet significantly increased VLDL-apo B (+34%), and decreased LDL-cholesterol (-18%) and LDL-apo B (-15%) as compared with starch alone; no differences were found in IDL and HDL between diets. The relative proportion of starch to sucrose in a diet appears to influence the magnitude of response of lipoproteins to dietary cholesterol.
authors: Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
authors: S R
authors: SR
authors: Srinivasan
authors: S
authors: S
authors: Spahn
authors: Y K
authors: YK
authors: Chiang
authors: B
authors: B
authors: Radhakrishnamurthy
authors: G S
authors: GS
authors: Berenson
mesh_terms: D000818:Animals; D001053:Apolipoproteins / Q000097:blood; D002791:Cholesterol, Dietary / Q000494:pharmacology; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004041:Dietary Fats / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008252:Macaca fascicularis; D008297:Male; D013213:Starch / Q000494:pharmacology*; D013395:Sucrose / Q000494:pharmacology*
chemical_list: D001053:Apolipoproteins; D002791:Cholesterol, Dietary; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D008055:Lipids; D008074:Lipoproteins; D013395:Sucrose; D013213:Starch