Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. I. The producing organism, fermentation, isolation and biological properties.
A new cytotoxic and antifungal antibiotic, neihumicin, was isolated from the culture broth of a soil isolate identified as Micromonospora neihuensis Wu, sp. nov. Neihumicin shows in vitro cytotoxicity against KB tissue culture cells (ED50 0.94 micrograms/ml) as well as antifungal activity against Saccharomyces cerevisiae ATCC 9763.
Wu
R Y
RY
Institute of Botany, Academia Sinica, Taipei, Taiwan, Republic of China.
Yang
L M
LM
Yokoi
T
T
Lee
K H
KH
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D008847:Micromonospora / Q000378:metabolism* / Q000648:ultrastructure; D011719:Pyrazines / Q000302:isolation & purification / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D011719:Pyrazines; C056028:neihumicin