title: Subclinical left ventricular abnormalities in young diabetics.
abstract: Twenty young asymptomatic diabetic patients were evaluated for left ventricular dysfunction by determining the radionuclide ejection fraction response to supine bicycle ergometry. The double product at peak exercise (28,743 +/- 3,314 vs 29,007 +/- 3,625, p greater than .05) was not significantly different between the two groups. Seven of 20 diabetics had either no change or a drop in their ejection fraction during exercise while 1 of 20 control subjects had no change in ejection fraction. There was no correlation between the FBS (r = .26) and HbA1c (r = .32) and ejection fraction change during exercise, although those diabetics with LV dysfunction tended to have a higher HbA1c level as compared to diabetics with a normal response (16.8 +/- 3.1 percent vs 12.5 +/- 3.8 percent respectively, p greater than .05). The LV systolic dysfunction in young asymptomatic diabetic subjects does not appear to correlate with the degree of acute or chronic hyperglycemia, and therefore, is not a direct function of the dynamic metabolic state of diabetes.
authors: Department of Medicine, Montefiore Hospital, Pittsburgh 15213-3241.
authors: S
authors: S
authors: Arvan
authors: K
authors: K
authors: Singal
authors: R
authors: R
authors: Knapp
authors: A
authors: A
authors: Vagnucci
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology*; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006331:Heart Diseases / Q000209:etiology; D006801:Humans; D008297:Male; D009200:Myocardial Contraction; D005082:Physical Exertion; D011877:Radionuclide Imaging; D013318:Stroke Volume