title: [Congenital hyperthyroidism caused by diaplacental exchange of thyrotropin receptor antibodies].
abstract: We describe the case of a premature baby, extremely small for date whose mother had an untreated hyperthyroidism during pregnancy. Severe symptoms of connatal hyperthyroidism appeared after a latency period of seven days. As the underlying cause we suggest the placental transmission of thyrotropin-receptor-antibodies (TRAb), which were elevated in the mother and the newborn. Main symptoms in the newborn were tachycardia, tachypnea, sweating and diarrhea.
authors: Universitäts-Kinderklinik Graz.
authors: H
authors: H
authors: Eyb
authors: H
authors: H
authors: Sperger
authors: M
authors: M
authors: Borkenstein
authors: W
authors: W
authors: Müller
authors: A
authors: A
authors: Passath
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D006111:Graves Disease / Q000276:immunology; D006801:Humans; D006980:Hyperthyroidism / Q000151:congenital* / Q000276:immunology; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011989:Receptors, Thyrotropin / Q000276:immunology*; D013960:Thyroid Function Tests
chemical_list: D001323:Autoantibodies; D011989:Receptors, Thyrotropin
vernacular_title: Connatale Hyperthyreose durch diaplazentar übertragene Thyreotropin-Rezeptoren-Antikörper (TRAK).