title: [Effective synthesis of cyclic analogs of bradykinin].
abstract: Cyclo-epsilon-(L-lysine1, glycine6-bradykinin) (CLGB) and cyclo-epsilon-kallidin have been synthesised in solution. To prepare linear precursors, fragment condensation (3 + 3 or 4) + 3 was used. Peptide bond formation, including cyclization, was carried out mainly through intermediate pentafluorophenyl esters. After purification on silicagel, protected cyclopeptides were obtained with a 50 to 60% yield. The protecting groups were eliminated by treatment with hydrogen fluoride in the presence of anisole. CLGB and CK were purified by droplet countercurrent chromatography and by reversed-phase HPLC, respectively.
authors: I E
authors: IE
authors: Mutule
authors: F K
authors: FK
authors: Mutulis
authors: D P
authors: DP
authors: Erglis
authors: D A
authors: DA
authors: Iakstrinia
authors: I P
authors: IP
authors: Sekatsis
mesh_terms: D001920:Bradykinin / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D007609:Kallidin / Q000031:analogs & derivatives / Q000138:chemical synthesis; D010456:Peptides, Cyclic / Q000138:chemical synthesis*
chemical_list: D010456:Peptides, Cyclic; D007609:Kallidin; D001920:Bradykinin
vernacular_title: Effektivnyĭ sintez tsiklicheskikh analogov bradikinina.