title: Scientific vs. statistical inference: the problem of multiple contrasts in clinical research.
abstract: The problem of type 1 error rates in clinical medicine research is discussed and a new measure of evaluating the incidences of type 1 error is presented. Three measures, including the experimentwise error rate, the error rate per experiment, and the percentage error rate are used to compute the type 1 error in a sample of clinical research. The results suggest the presence of a substantial incidence of type 1 error in the sampled research. The implications for statistical and scientific inferences are briefly discussed and some possible solutions explored.
authors: University of Wisconsin-Madison 53706.
authors: K J
authors: KJ
authors: Ottenbacher
mesh_terms: D012106:Research; D013223:Statistics as Topic