Environmental-genetic interactions in experimental hypertension: the Dahl rat model.
Dahl selected lines of salt-sensitive rats respond to hypertensinogenic stimuli such as sodium or behavioral stressors with marked elevations in blood pressure. In contrast, Dahl salt-resistant rats do not. The two lines appear to differ in terms of heart-rate reactivity and central nervous system organization.
Friedman
R
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Department of Psychiatry and Behavioral Science, School of Medicine Health Sciences Center, State University of New York, Stony Brook 11794-8790.
D000818:Animals; D004195:Disease Models, Animal; D006321:Heart / Q000503:physiopathology; D006973:Hypertension / Q000209:etiology* / Q000235:genetics / Q000523:psychology; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D012965:Sodium Chloride / Q000009:adverse effects; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology
D012965:Sodium Chloride