title: Collagen-type synthesis in human-hair papilla cells in culture.
abstract: Hair-papilla derived cells were grown in monolayer culture and revealed the typical morphology and growth pattern which was similar but not identical to control fibroblasts. Hair-papilla cells were found to produce considerable amounts of collagen type I and type III and fibronectin. Type IV collagen production could not be detected. The ratio of collagen type III and type I clearly differed from the pattern observed in normal fibroblasts, being much higher in hair-papilla cells, where type III accounted for more than 20% of total collagen synthesis. These data show that hair-papilla derived cells have biosynthetic capacities similar to those of human skin fibroblasts as well as characteristic differences, indicating that they represent a specialized fibroblast subpopulation.
authors: Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, FRG.
authors: K
authors: K
authors: Katsuoka
authors: C
authors: C
authors: Mauch
authors: H
authors: H
authors: Schell
authors: O P
authors: OP
authors: Hornstein
authors: T
authors: T
authors: Krieg
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism; D006197:Hair / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged
chemical_list: D003094:Collagen