Effects of methsuximide on schedule-controlled responding in the pigeon.
Acute and chronic effects of methsuximide (25, 50, 75, and 100 mg/kg), a succinimide with anticonvulsant properties, were examined in pigeons responding under a multiple fixed-ratio 50 fixed-interval 90-sec schedule of food delivery. The clearest acute effect of methsuximide was a substantial reduction in response rates under both components of the multiple schedule when the drug was administered at 100 mg/kg. Detailed analysis of the temporal distribution of responding under the fixed-interval failed to reveal rate-dependent drug effects. Tolerance appeared to develop to the effects of methsuximide when the drug was administered chronically.
Delaney
D
D
Department of Psychology, Western Michigan University, Kalamazoo 49008.
Pellettiere
V
V
Schlinger
H
H
Poling
A
A
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D010856:Columbidae; D003216:Conditioning, Operant / Q000187:drug effects*; D004361:Drug Tolerance; D005260:Female; D012055:Reinforcement Schedule; D013388:Succinimides / Q000494:pharmacology*
D000927:Anticonvulsants; D013388:Succinimides; C100286:methsuximide