A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe.
In fission yeast, meiosis is initiated by transcriptional activation of the mei3+ gene, under the combined influence of the four mating-type genes. The product of the mei3+ gene acts as a critical meiotic inducer by binding non-covalently to a newly identified protein kinase encoded by the ran1+ gene and inhibiting its enzymatic activity. Inactivation of the ran1+ protein kinase is both necessary and sufficient to divert a vegetative cell from mitotic division to meiotic differentiation.
McLeod
M
M
Cold Spring Harbor Laboratory, New York 11724.
Beach
D
D
D005656:Fungal Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000502:physiology*; D005800:Genes, Fungal; D049770:Genes, Mating Type, Fungal; D000072235:Mating Factor; D008540:Meiosis; D010455:Peptides / Q000502:physiology; D010766:Phosphorylation; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000235:genetics / Q000502:physiology; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D004718:Saccharomycetales / Q000502:physiology*; D012568:Schizosaccharomyces / Q000235:genetics / Q000502:physiology*
D005656:Fungal Proteins; D010455:Peptides; D047428:Protein Kinase Inhibitors; D011993:Recombinant Fusion Proteins; D000072235:Mating Factor; D011494:Protein Kinases