[Antioxidative effect of o-benzoquinone derivatives during CCl4-induced lipid peroxidation in the rat liver].
It was found that o-benzoquinones (oBQ) inhibit the CCl4-dependent lipid peroxidation (LPO) in rat liver microsomes in vitro. The experimental data suggest that the antioxidant effect of oBQ is not due to the ability of these substances to shunt the NADPH-dependent electron transport pathways. More likely, oBQ inhibit LPO due to the ability of their reduced forms to scavenge the free radicals which induce LPO. Based on the experimental data, it was concluded that the increasing absorption of liver lipids at 230-236 nm after administration of CCl4 is due to the accumulation of reduced hydroperoxides. This process was shown to be inhibited by oBQ.
Potapovich
A I
AI
Kostiuk
V A
VA
D000818:Animals; D000975:Antioxidants; D016227:Benzoquinones; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors / Q000633:toxicity*; D066298:In Vitro Techniques; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D011809:Quinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013858:Thiobarbiturates / Q000378:metabolism
C017007:4-anilino-5-methoxy-1,2-benzoquinone; D000975:Antioxidants; D016227:Benzoquinones; D008054:Lipid Peroxides; D011809:Quinones; D013858:Thiobarbiturates; D008315:Malondialdehyde; D002251:Carbon Tetrachloride; C029684:thiobarbituric acid; C025225:2-benzoquinone
Antiokislitel'noe deĭstvie proizvodnykh o-benzokhinona v usloviiakh CCl4-indutsiruemogo perekisnogo okisleniia lipidov v pecheni krys.