[Effect of heparin on fibrinogen formation during experimental toxic syndrome of disseminated intravascular coagulation].
The formation of circulation components of fibrinogen pool in toxigenic syndrome of disseminated intravascular blood coagulation (DBC-syndrome) caused by the Vipera lebetina turanica venom has been examined by the gel-filtration method. Simultaneously it has been studied what components of fibrinogen pool are removed in paracoagulation tests and with addition of the coagulating enzymes (thrombin, reptilase and the Echis multisguamatus venom) to the plasma. The preliminary heparinization of animals poisoned by Vipera lebetina turanica venom was found to prevent the fibrinogen formation mainly at the fibrin-monomer formation stage. Besides, the effect of polymerization inhibition was revealed in the plasma of such animals.
Barkagan
Z S
ZS
Momot
A P
AP
Glazunova
G A
GA
Taranina
T S
TS
Koltakova
S I
SI
D000818:Animals; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000139:chemically induced / Q000517:prevention & control; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000096:biosynthesis*; D006493:Heparin / Q000494:pharmacology*; D011817:Rabbits; D013917:Thrombin / Q000032:analysis; D014757:Viper Venoms / Q000633:toxicity
D005338:Fibrin Fibrinogen Degradation Products; D014757:Viper Venoms; D005340:Fibrinogen; D006493:Heparin; D013917:Thrombin
Vliianie geparina na fibrinoobrazovanie pri éksperimental'nom toksogennom sindrome disseminirovannogo vnutrisosudistogo svertyvaniia krovi.