2,3-Diphosphoglycerate in normal, anaemic and transfused human fetuses.
1. The effect of anaemia and transfusion with adult blood on fetal 2,3-diphosphoglycerate levels was investigated by studying fetal blood from 45 normal pregnancies at 17-42 weeks of gestation and in 34 pregnancies complicated by erythroblastosis fetalis. 2. In normal fetuses, 2,3-diphosphoglycerate concentration was higher than in adults and did not change significantly with gestational age. 3. In erythroblastotic fetuses, there was a significant negative correlation between 2,3-diphosphoglycerate concentration and haemoglobin concentration. 4. When adult blood was transfused into the fetal circulation, 2,3-diphosphoglycerate concentration reached similar levels to that found in untransfused fetuses after allowing for the severity of anaemia.
Soothill
P W
PW
Harris Birthright Research Centre for Fetal Medicine, Department of Obstetrics and Gynaecology, King's College School of Medicine and Dentistry, London.
Lestas
A N
AN
Nicolaides
K H
KH
Rodeck
C H
CH
Bellingham
A J
AJ
D019794:2,3-Diphosphoglycerate; D000328:Adult; D001805:Blood Transfusion, Intrauterine; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004899:Erythroblastosis, Fetal / Q000097:blood*; D004906:Erythrocyte Count; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D005865:Gestational Age; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D012156:Reticulocytes
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D019794:2,3-Diphosphoglycerate