Pharmacokinetics of chlortetracycline in the turkey: evaluation of biliary secretion.
The pharmacokinetics of chlortetracycline (CTC) in plasma and bile after intravenous administration in turkeys was ascertained. After a dose of CTC (0.9 mg/kg) was administered IV, 8.5% of the dose appeared in the bile in 4 hours. The peak bile/plasma concentration ratio for CTC was 254 at 2 hours. The bile/plasma concentration ratio was greater than 1 from 10 to 240 minutes after CTC administration.
Dyer
D C
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Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Iowa State University, Ames 50011.
D000818:Animals; D001646:Bile / Q000032:analysis / Q000378:metabolism*; D002751:Chlortetracycline / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D014422:Turkeys / Q000378:metabolism*
D002751:Chlortetracycline