title: Age-related differences in seizure susceptibility to flurothyl.
abstract: The purpose of the present study was to determine whether the susceptibility to seizures induced by inhalation of flurothyl ether (FE) varies with age. Adult rats and 16-day-old rat pups were tested in different sized chambers to also determine whether the size of the FE-test chamber influences seizure thresholds. Results indicate that pups developed age-specific seizure patterns; their seizure latency thresholds were shorter than those of adult animals. For both age-groups, seizure thresholds varied as a function of chamber size; the smaller the chamber the faster seizures occurred.
authors: Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461.
authors: E F
authors: EF
authors: Sperber
authors: S L
authors: SL
authors: Moshé
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology*; D000818:Animals; D005481:Flurothyl / Q000633:toxicity*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced*
chemical_list: D005481:Flurothyl