The cholecystokinin antagonist L-364,718 inhibits the action of cholecystokinin but not bombesin on rat pancreatic secretion in vivo.
The action of an antagonist of peripheral CCK receptors, L-364,718 on CCK8 and bombesin-induced pancreatic exocrine secretion was studied in anaesthetized rats. Both CCK8 and bombesin increased the rate of flow and rate of enzyme secretion from the pancreas. Intravenous L-364,718 inhibited the actions of CCK8, but not those of bombesin. It is concluded that bombesin acts on the exocrine pancreas directly rather than through the release of CCK.
Anderson
L
L
Physiological Laboratory, University of Liverpool, U.K.
Dockray
G J
GJ
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D001839:Bombesin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D020109:Devazepide; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D001570:Benzodiazepinones; D002766:Cholecystokinin; D020109:Devazepide; D001839:Bombesin