title: Phosphorylation of the 90 kDa heat shock protein in heat shocked HeLa cell lysates.
abstract: The 90 kDa heat shock protein (hsp 90) is a major phosphorylated protein under normal growth conditions. However, it does not incorporate detectable levels of phosphate by incubation of control HeLa cell lysates with [gamma-32P]ATP in vitro. In this paper we show that strong phosphorylation of hsp 90 occurs in lysates prepared from heat shocked HeLa cells. Possible involvement of the eukaryotic initiation factor 2 kinase of the heme-controlled repressor of translation is discussed.
authors: Groupe de Biologie Moléculaire du Stress, Institut Pasteur, Paris, France.
authors: V
authors: V
authors: Legagneux
authors: M F
authors: MF
authors: Dubois
authors: M
authors: M
authors: Morange
authors: O
authors: O
authors: Bensaude
mesh_terms: D006367:HeLa Cells / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006358:Hot Temperature; D006801:Humans; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D019892:eIF-2 Kinase
chemical_list: D006360:Heat-Shock Proteins; D011494:Protein Kinases; D019892:eIF-2 Kinase