Assessment of the effects of a topical product containing glycosaminoglycans in cutaneous hydration.
The hydrating power of a topically applied mixture of glycosaminoglycans has been evaluated by means of an electrical impedance method. The electrical parameters investigated, namely angle alpha and R infinity, are related to the permeability and the hydration of deeper tissues. The study revealed lowering of alpha levels after the application of the product, thus signifying an accumulation of electrical charges in the epidermis consistent with the penetration of glycosaminoglycans. After 15 days of treatment, significant reduction of R infinity levels was recorded. The relationship between R infinity levels, dermal water content and glycosaminoglycans is discussed.
Berardesca
E
E
Department of Dermatology, University of Pavia, Italy.
Gabba
P
P
Borroni
G
G
Rabbiosi
G
G
D000287:Administration, Topical; D000328:Adult; D004558:Electric Stimulation; D004594:Electrophysiology; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D012867:Skin / Q000187:drug effects / Q000378:metabolism*
D006025:Glycosaminoglycans