Prevalence of ABO maternal-infant incompatibility in Asians, Blacks, Hispanics and Caucasians.
Previous studies suggest that race is a risk factor in ABO hemolytic disease of the newborn (ABO-HDN). In order to compare the prevalence of ABO-HDN in Asian, Black, Hispanic and Caucasian infants, we studied 10,611 consecutive births at one hospital over a 6-year period. Among group A infants born to group O mothers, the prevalence of positive DAT differed among the four groups (p = 0.007), and was highest in Asians (50%) and lowest in Caucasians (31%). However, the proportions of infants who required exchange transfusion were not different (p = 0.351). Among group B infants born to group O mothers, the prevalence of positive DAT was not different among the four groups (p = 0.26) and none of these 166 group B infants with a positive DAT result required exchange transfusion. Our findings suggest that there are small ethnic differences in the prevalence of positive DAT results in group A infants born to group O mothers, but the prevalence of clinical disease which requires exchange transfusion does not differ significantly among Asian, Black, Hispanic and Caucasian infants.
Toy
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Blood Bank, San Francisco General Hospital Medical Center, Calif.
Reid
M E
ME
Papenfus
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L
Yeap
H H
HH
Black
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D000017:ABO Blood-Group System; D044466:Asian People; D044383:Black People; D003298:Coombs Test; D004899:Erythroblastosis, Fetal / Q000453:epidemiology*; D005006:Ethnicity; D006801:Humans; D007231:Infant, Newborn; D044469:Racial Groups; D044465:White People
D000017:ABO Blood-Group System