Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains.
Competition experiments using (-)-[3H]nicotine and unlabelled nicotine revealed both high and low affinity nicotinic binding sites in temporal cortex of control and Alzheimer (AD/SDAT) brains. A significant reduction in the proportion of high affinity nicotinic binding sites (-20%) and a parallel increase in the proportion of low affinity nicotinic binding sites was obtained in AD/SDAT brain cortex compared to control brain. Moreover, a marked decrease was observed in the affinity of the low affinity nicotinic binding sites in AD/SDAT.
Nordberg
A
A
Department of Pharmacology, University of Uppsala, Sweden.
Adem
A
A
Hardy
J
J
Winblad
B
B
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009538:Nicotine / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000145:classification / Q000378:metabolism*; D013702:Temporal Lobe / Q000378:metabolism*
D011978:Receptors, Nicotinic; D009538:Nicotine