Affective cycling in thyroid disease.
Depression in an elderly man with primary recurrent unipolar depression responded to radioactive iodine treatment of a thyrotoxic nodule, without the addition of psychotropic medications. Two months later, manic symptoms developed concomitant with the termination of the hyperthyroid state secondary to the radioactive iodine treatment. Clinical implications of these findings in relation to the possible mechanism of action of thyroid hormones on affective cycling are discussed.
Tapp
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Department of Psychiatry, University of Michigan, Ann Arbor 48109.
D000368:Aged; D001714:Bipolar Disorder / Q000209:etiology*; D003866:Depressive Disorder / Q000209:etiology*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D013959:Thyroid Diseases / Q000150:complications* / Q000532:radiotherapy; D013971:Thyrotoxicosis / Q000150:complications / Q000532:radiotherapy
D007457:Iodine Radioisotopes