Inhibitory effect of prolonged administration of tetragastrin on experimentally induced intestinal metaplasia in Wistar rats.
The effect of tetragastrin on the induction of intestinal metaplasia by intragastric administration of 5% NaOH solution was investigated in Wistar rats. The prolonged administration of tetragastrin in depot form from 1 week after NaOH treatment resulted in a significant increase in basal gastric acid secretion and a significant reduction in the incidence and number of intestinal metaplasia in experiment week 35. A histologic examination showed goblet cell metaplasia and intestinal metaplasia without Paneth cells in rats treated only with olive oil. Only goblet cell metaplasia was found in rats treated with tetragastrin. These results show that the prolonged administration of tetragastrin to rats after NaOH treatment increases gastric acid secretion and suppresses the induction of intestinal metaplasia.
Tatsuta
M
M
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
Yamamura
H
H
Baba
M
M
Yamamoto
R
R
Iishi
H
H
Taniguchi
H
H
D000818:Animals; D003692:Delayed-Action Preparations; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D005755:Gastrins / Q000378:metabolism / Q000627:therapeutic use*; D008297:Male; D008679:Metaplasia; D051381:Rats; D011919:Rats, Inbred Strains; D012972:Sodium Hydroxide / Q000633:toxicity; D013758:Tetragastrin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D005755:Gastrins; D013758:Tetragastrin; D012972:Sodium Hydroxide