Risk of stomach cancer in association with serum cholesterol and beta-lipoprotein.
The relation between serum levels of cholesterol and beta-lipoprotein (BLP) and stomach cancer risk was studied in a Swedish cohort of 92,710 individuals. The cohort was examined with a single measurement of cholesterol and BLP between 1963 and 1965 and followed up in the Swedish Cancer Registry until 1983. During the follow-up period 576 stomach cancers were reported. The risk of stomach cancer was negatively correlated to serum levels of cholesterol with a relative risk (RR) of 0.85 for every 40 mg/dl increase of cholesterol (p less than 0.001) and to BLP with an RR of 0.90 for every 3 units increase of BLP (p less than 0.01) when analysed one at a time. In a multiple regression analysis, however, only the relation to cholesterol remained statistically significant. The risk association seemed to be most pronounced between the third and fifth years of follow-up.
Törnberg
S A
SA
Department of General Oncology, Karolinska Sjukhuset, Stockholm, Sweden.
Carstensen
J M
JM
Holm
L E
LE
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology*; D013548:Sweden
D008077:Lipoproteins, LDL; D002784:Cholesterol