Comparison of serum sampling methods for determining vancomycin dosage regimens.
The predictive ability of a four-point sampling method versus a two-point sampling method for vancomycin was assessed in 11 patients with various staphylococcal infections. All steady-state predictions were based on first-dose pharmacokinetic parameters. The mean vancomycin serum concentrations achieved at 4 and 8 h postinfusion were not significantly different from the predicted concentrations derived from either the four- or two-point method. Also, there was no significant difference between the two methods in predictive ability or accuracy. Both methods underpredicted the steady-state concentration to the same degree, 2.9 micrograms/ml at 4 h and 3.1 micrograms/ml at 8 h, which would appear to be clinically acceptable. A one-compartment pharmacokinetic model, which uses two serum concentrations, appears to be adequate for adjusting vancomycin regimens.
Albrecht
L M
LM
Department of Pharmacy Practice, Wayne State University, Detroit, Michigan.
Rybak
M J
MJ
Boike
S C
SC
Pancorbo
S
S
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008433:Mathematics; D008722:Methods; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000097:blood / Q000188:drug therapy; D014640:Vancomycin / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics
D014640:Vancomycin