Prevention of enteral radiocesium absorption by hexacyanoferrates(II) in piglets.
The efficacy of different hexacyanoferrates(II) in preventing the enteral absorption of 134Cs was studied in piglets. As compared to the controls, oral application of 134Cs together with KFe[Fe(CN)6], NH4Fe[Fe(CN)6], or Fe4[Fe(CN)6]3 resulted in a strong reduction of the 134 Cs-uptake by more than 97%. The decrease in enteral absorption depends on the dose of administered hexacyanoferrate(II), whereas differences between the compounds under study were small. The biological half-life of 134Cs in non-hexacyanoferrate(II) treated piglets was 21.6 +/- 3.3 days (mean +/- SD).
Nielsen
P
P
Institut für Physiologische Chemie, Universitätskrankenhaus Eppendorf, Hamburg, Federal Republic of Germany.
Fischer
R
R
Heinrich
H C
HC
Pfau
A A
AA
D000818:Animals; D001822:Body Burden; D002588:Cesium Radioisotopes / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005295:Ferrocyanides / Q000008:administration & dosage / Q000494:pharmacology*; D006207:Half-Life; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D013552:Swine
D002588:Cesium Radioisotopes; D005295:Ferrocyanides; C020354:hexacyanoferrate II