[Functional activity of the adrenal glands and the hormone-protein interactions in patients with hypertension with a complicated course].
Patients with essential hypertension and hypertension complicated by coronary heart disease showed adrenal glucocorticoid activation along with reduced transcortin binding capacity (TBC). The addition of circulatory insufficiency (stage I and IIB) resulted in a decrease of the functional adrenal reserve and further diminution of TBC due to a reduction of protein binding sites concentration, and sometimes (stage IIB) also a decrease in the protein affinity of steroids. A correlation between TBC and plasma protein level was found. The absence of adrenal functional response to an abrupt drop in TBC is interpreted as a complete failure of the adaptation systems.
Nadol'nik
L I
LI
Galitskiĭ
E A
EA
Beluga
V G
VG
Butkevich
N D
ND
Vodoevich
V P
VP
D015062:11-Hydroxycorticosteroids / Q000378:metabolism*; D000302:Adrenal Cortex / Q000378:metabolism*; D000328:Adult; D003327:Coronary Disease / Q000150:complications / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged; D011485:Protein Binding; D014156:Transcortin / Q000378:metabolism*
D015062:11-Hydroxycorticosteroids; D014156:Transcortin
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