Blockade of the histamine H1-receptor in the rat ventromedial hypothalamus and feeding elicitation.
All H1-, but no H2-antagonists infused into the rat third cerebroventricle, induced feeding during the early light, but not during the early dark, reflecting a concentration of hypothalamic histamine. Bilateral microinfusion identified the ventromedial hypothalamus (VMH), but not the lateral hypothalamus or the paraventricular nucleus, as a main locus for the induction of feeding by an H1-antagonist. The effect was completely abolished when brain histamine was decreased by pretreatment with alpha-fluoromethylhistidine. Hypothalamic neuronal histamine suppresses food intake, at least in part, through H1-receptors in the VMH.
Sakata
T
T
Department of Internal Medicine I, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Ookuma
K
K
Fukagawa
K
K
Fujimoto
K
K
Yoshimatsu
H
H
Shiraishi
T
T
Wada
H
H
D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D002744:Chlorpheniramine / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D007839:Functional Laterality; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011968:Receptors, Histamine / Q000187:drug effects*; D011969:Receptors, Histamine H1 / Q000187:drug effects*; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*
D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D002744:Chlorpheniramine; D002927:Cimetidine