[Basic and clinical studies on ceftriaxone in perinatal infections].
Basic and clinical investigations were conducted on ceftriaxone (CTRX), a cephem antibiotic with a wide antibacterial spectrum and with especially high activity against Gram-negative bacteria. The results obtained are summarized as follows: 1. CTRX, following intravenous drip infusion of 1 g, had a serum half-life of 5.8 hours, which is longer than that of any other existing cephem antibiotics. 2. The level of CTRX in the umbilical cord serum 6 hours after intravenous drip infusion of 1 g was at a satisfactory level, 15 micrograms/ml. 3. The CTRX was remarkably effective or effective in 9 cases, and the activity was high even in cases where penicillin or other third-generation cephems were ineffective. These results seem to indicate that CTRX may be effective in perinatal and intrauterine fetal infections.
Soma
A
A
Department of Obstetrics and Gynecology, Asahikawa Medical College.
Hayakawa
K
K
Asakawa
T
T
Ishikawa
M
M
Mure
K
K
Yamashita
K
K
Shimizu
T
T
Haga
H
H
Saito
S
S
Yamazaki
T
T
D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism; D002443:Ceftriaxone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004716:Endometritis / Q000188:drug therapy*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007262:Infusions, Intravenous; D011247:Pregnancy; D011645:Puerperal Infection / Q000188:drug therapy*
D002443:Ceftriaxone