Anti-fertility and other actions of gossypol analogues.
From a series of gossypol derivatives studied, we conclude that the carbonyl groups of gossypol are needed for inhibition of erythrocyte anion transport and the hydroxy groups affect but are not essential to that inhibition. In an in vitro mouse erythroleukemia cytocidal assay, the most active compounds were gossypol and apogossypol. The latter was not active in the inhibition of erythrocyte anion transport or in a spermicidal assay. Of the more simple structures related to gossypol, those that were active in the cytocidal and spermicidal assays were bi-aromatic, linked by a 1- and not a 4-carbon chain and had free phenolic hydroxyl groups. These results are included in a discussion of the specificity and mechanism of action of gossypol.
Sonenberg
M
M
Memorial Sloan-Kettering Cancer Center, New York, NY.
Huang
J T
JT
Ren
Y F
YF
Su
T L
TL
Watanabe
K A
KA
Haspel
H C
HC
Corin
R E
RE
Hoffer
A P
AP
D000818:Animals; D000838:Anions / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D005298:Fertility / Q000187:drug effects*; D006072:Gossypol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques; D007267:Injections; D007474:Ion Exchange; D008297:Male; D051381:Rats; D012671:Seminiferous Tubules / Q000187:drug effects / Q000648:ultrastructure; D013081:Sperm Motility / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000648:ultrastructure
D000838:Anions; D006072:Gossypol