[Stomach tumors in rats induced by a single administration of N-methyl-N-nitro-N-nitrosoguanidine and N-methyl-N-nitrosourea].
The pathologic characteristics of gastric tumors induced by single injections of N-methyl-N'-nitro-N-nitrosoguanidine (15 mg) solution and N-methyl-N-nitrosourea (10 mg) solution in 0.1 ml dimethylformamide were studied in 23 noninbred rats. The chemicals were injected into the antropyloric segment of the stomach. By months 11-15, specific changes in the glandular epithelium had developed at that site in 20 rats: dysplasia--in 6, precancer--7, and adenocarcinoma in 7 animals. Also, there were papillomas (6), squamous cell carcinoma (3), precancer and sarcoma (4) in various segments of the organ.
Vol'fson
N I
NI
Pliss
G B
GB
Petrov
A S
AS
Zaozerskaia
L A
LA
Kalinovskiĭ
V P
VP
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D003043:Cocarcinogenesis; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000008:administration & dosage*; D008770:Methylnitrosourea / Q000008:administration & dosage*; D010212:Papilloma / Q000139:chemically induced; D011230:Precancerous Conditions / Q000139:chemically induced; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced; D013274:Stomach Neoplasms / Q000139:chemically induced*
D008769:Methylnitronitrosoguanidine; D008770:Methylnitrosourea
Opukholi zheludka u krys pri odnokratnom vvedenii N-metil-N-nitro-N-nitrozoguanidine i N-metil-N-nitrozomocheviny.