Peroxisomes in the rat brain and the effects of di-(2-ethylhexyl) phthalate during postnatal development. An electron-microscopic study.
Peroxisomes were identified in the neurons of cerebral cortex of 12-day-old suckling rats from normal and plasticizer di-(2-ethylhexyl) phthalate (DEHP)-fed mothers. The study suggests that DEHP passed to the pups through the mother's milk during nursing can induce peroxisomal proliferation in neurons during postnatal development.
Dabholkar
A S
AS
Department of Biological Sciences, Wright State University, Dayton, Ohio.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000254:growth & development* / Q000648:ultrastructure; D004051:Diethylhexyl Phthalate / Q000494:pharmacology*; D005260:Female; D008297:Male; D008830:Microbodies / Q000187:drug effects* / Q000648:ultrastructure; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure; D010795:Phthalic Acids / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
D010795:Phthalic Acids; D004051:Diethylhexyl Phthalate