title: Variability of the thymidine labeling index in squamous cell carcinoma of the head and neck.
abstract: Tritiated thymidine (3HTdR) labeling is the standard technique for determining the kinetic activity of tumors. This method has been used to label multiple sections of tumor specimens obtained from seven patients with advanced squamous cell carcinoma of the head and neck. Considerable variability was observed in the labeling index in different sites from the same specimen. To reduce the large sampling error due to heterogeneity, we recommend that an average value be determined from multiple sections when employing this technique.
authors: Division of Hematology/Oncology, University of Connecticut Health Center, Farmington 06032.
authors: B
authors: B
authors: Greenberg
authors: L
authors: L
authors: Woo
authors: S
authors: S
authors: Blatchford
authors: M
authors: M
authors: Aguirre
authors: H
authors: H
authors: Garewal
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D002455:Cell Division; D004273:DNA, Neoplasm / Q000096:biosynthesis; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007700:Kinetics; D011379:Prognosis; D013936:Thymidine; D014316:Tritium
chemical_list: D004273:DNA, Neoplasm; D014316:Tritium; D013936:Thymidine