[Comparative analysis of the morphochemical changes in the visual and sensorimotor cortical neurons of rats exposed to taftsin].
White rats were treated with a single administration of immunostimulator tuftsin (Thr-Lys-Pro-Arg, in the dose 300 mcg/kg b. w.). By interferometry protein content and concentration and the area of neuron cytoplasm and nucleus were assessed 15 minutes after injection, significant alterations in protein content and cellular area were detected in one type neurons of visual and sensomotor cortex. A possible interrelation is discussed between tuftsin action and the functional activity of neurons, and between the level of their protein metabolism and establishment of emotional and motor response.
Chebotareva
T L
TL
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D006651:Histocytochemistry; D007368:Interferometry; D008027:Light; D008297:Male; D009044:Motor Cortex / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D014405:Tuftsin / Q000494:pharmacology*; D014793:Visual Cortex / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D009419:Nerve Tissue Proteins; D014405:Tuftsin
Sravnitel'nyĭ analiz morfokhimicheskikh izmeneniĭ v neĭronakh zritel'noĭ i sensomotornoĭ kory mozga krys pri vozdeĭstvii taftsina.