[Antidotal and antineoplastic properties of copper sulfate].
Copper sulfate in peroral administration to small experimental animals has an inhibitory effect on the growth of transplanted solid tumors and possesses antidote properties in respect to cisplatin. An antitumor effect of the compound was registered at doses ranging from 10 to 120 mg/kg. Antidote properties are manifested clearly when copper sulfate is applied at a single dose 10 mg/kg, 24 hours before cisplatin administration. It has been determined that copper sulfate decreases acute toxicity, nephro- and hemotoxicity of cisplatin, but fails to change its antitumor effect. The experimental data obtained give the ground for the clinical studies of copper sulfate.
Syrkin
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D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use / Q000633:toxicity*; D003300:Copper / Q000627:therapeutic use*; D019327:Copper Sulfate; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*
D000931:Antidotes; D000970:Antineoplastic Agents; D003300:Copper; D019327:Copper Sulfate; D002945:Cisplatin
Antidotnye i protivoopukholevye svoĭstva sul'fata medi.