Improved diagnostic procedures in allergic RAST negative rhinitis.
Patients affected by cutinegative, RAST negative, chronic hyperreactive rhinitis showed in 15/28 cases positive intradermal tests, nasal provocation test and RAST on nasal fluids. In 13/28 cases high IgE on nasal samples could be observed and seldom were the intradermal tests positive, but in no case were the nasal provocation or nasal RAST positive. Delayed and late positive provocation tests showed different features from early reactions. Criteria of positivity and checks during provocation tests look critical. The occurrence of sinusitis and polyposis can change clinical features. Mediators released from tissues lead to bronchial hyperreactivity.
Valerio
G
G
Divisione di Fisiopatologia Respiratoria, Policlinico di Bari, Italy.
Cassano
P
P
Attimonelli
R
R
Salerno
F G
FG
D004804:Eosinophils / Q000166:cytology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007428:Intradermal Tests; D007958:Leukocyte Count; D009298:Nasal Polyps / Q000209:etiology; D009299:Nasal Provocation Tests; D009504:Neutrophils / Q000166:cytology; D011852:Radioallergosorbent Test; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis*
D007073:Immunoglobulin E