title: Inheritance of diabetes mellitus in Keeshond dogs.
abstract: The genetic aspects of inherited, insulin-dependent diabetes mellitus of Keeshond dogs were studied retrospectively and in a prospective mating program. The symbol dm was used to designate the gene that causes hypoplasia of the islets of Langerhans. The retrospective study disclosed 4 diabetic dogs; prospective outcross, backcross, and inbred matings disclosed 49 diabetic dogs. Outcrossing demonstrated that the diabetic phenotype was displayed readily against a genetic background of a breed other than the Keeshond. In dogs with the dm/dm genotype, onset of diabetes was most frequent before the dog was 6 months old, but did occur in some older dogs. The dm genotype was best described as autosomal recessive.
authors: College of Veterinary Medicine, Washington State University, Pullman 99164.
authors: J W
authors: JW
authors: Kramer
authors: J K
authors: JK
authors: Klaassen
authors: D G
authors: DG
authors: Baskin
authors: D J
authors: DJ
authors: Prieur
authors: N W
authors: NW
authors: Rantanen
authors: J D
authors: JD
authors: Robinette
authors: W R
authors: WR
authors: Graber
authors: L
authors: L
authors: Rashti
mesh_terms: D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000662:veterinary*; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D005838:Genotype; D008297:Male; D010375:Pedigree; D011446:Prospective Studies; D012189:Retrospective Studies