title: [Immunodeficiencies and lymphoma].
abstract: Primary immunodeficiencies (ID) lead to a high incidence of cancer, particularly of lymphomas. The risk excess varies according to the type of ID. Cellular IDs carry a very high risk, tumoral IDs have an intermediate risk while deficiencies of non-specific immunity bear no risk. Acquired IDs are also associated with an increased risk of lymphomas. The physiopathogeny of ID-associated lymphomas remains unknown, although several hypotheses have been proposed, including a defective immunological surveillance, repeated viral and antigenic stimulations and DNA repair anomalies.
authors: Groupe de recherches d'immunologie et de rhumatologie pédiatriques, Hôpital des Enfants-Malades, Paris, France.
authors: A
authors: A
authors: Fischer
authors: C
authors: C
authors: Griscelli
mesh_terms: D004260:DNA Repair; D006801:Humans; D007109:Immunity; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000503:physiopathology; D008223:Lymphoma / Q000150:complications* / Q000209:etiology / Q000503:physiopathology; D012307:Risk Factors
vernacular_title: Déficits immunitaires et lymphomes.