Verapamil-induced carbamazepine neurotoxicity. A report of two cases.
Two patients with signs of carbamazepine neurotoxicity after combined treatment with verapamil showed complete recovery after discontinuation of the calcium entry blocker. Use of verapamil in combination with carbamazepine should either be avoided or prescribed only with appropriate adjustment of the carbamazepine dose (usually reduction of the carbamazepine dose by one half).
Beattie
B
B
Department of Neurology, University of Iowa College of Medicine, Iowa City.
Biller
J
J
Mehlhaus
B
B
Murray
M
M
D000328:Adult; D001259:Ataxia / Q000139:chemically induced*; D002220:Carbamazepine / Q000009:adverse effects* / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008875:Middle Aged; D012640:Seizures / Q000139:chemically induced*; D014700:Verapamil / Q000009:adverse effects* / Q000378:metabolism
D002220:Carbamazepine; D014700:Verapamil