Different antagonistic effects of bunazosin and ketanserin on the norepinephrine-induced vasoconstriction in isolated, perfused canine and simian skeletal muscle arteries.
Blocking activities of bunazosin and ketanserin on norepinephrine (NE)-induced vasoconstrictions were investigated in isolated, perfused canine and simian skeletal muscle arteries. NE caused an increase in perfusion pressure in a dose-related manner to almost the same extent in both canine and simian arterial preparations. Bunazosin and ketanserin inhibited NE-induced vasoconstrictions much more readily in simian arteries than in canine arteries. The mechanisms for the different adrenolytic activities of alpha 1-antagonists between these two arteries were discussed.
Sinanović
O
O
Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Chiba
S
S
D000818:Animals; D001158:Arteries / Q000187:drug effects; D004285:Dogs; D005260:Female; D066298:In Vitro Techniques; D007650:Ketanserin / Q000494:pharmacology*; D008251:Macaca; D008297:Male; D009132:Muscles / Q000098:blood supply; D009638:Norepinephrine / Q000037:antagonists & inhibitors*; D011799:Quinazolines / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
D011799:Quinazolines; D007650:Ketanserin; C018176:bunazosin; D009638:Norepinephrine