title: [Diagnosis of myocardial ischemias with long-term electrocardiography: spontaneous variability and modification by nitrate therapy].
abstract: To evaluate spontaneous variability of ST-segment changes within the Holter ECG, in 20 patients with documented coronary heart disease (CHD) long-term ambulatory ECG recordings were performed over 3 consecutive days, when the patients were only receiving short-acting nitrates. ST-segment alterations per day were measured as the area beneath the baseline (mV x min), and were compared day-to-day intraindividually. The intra-day variations of ST-segment area alterations were a factor of about 10, when compared with the baseline values. Following administrations of 120 mg ISDN ret. at the beginning of day 4, the number of anginal attacks was reduced, as was the acute medication with short-acting nitrates. There was also a trend to reduction of ischemic ST-segment changes, but these reductions could not be confirmed statistically. In studies on the course and therapeutic interventions of patients with CHD, the phenomenon of spontaneous variability of ST-segment alterations must be taken into account--as applies also to the arrhythmia analysis within the Holter ECG--and the recording period must probably be prolonged beyond the 24-h limit presently used.
authors: Medizinische Klinik III, Universität Köln.
authors: A
authors: A
authors: Osterspey
authors: T
authors: T
authors: Eggeling
authors: C
authors: C
authors: Götz
authors: I
authors: I
authors: Treis
authors: H W
authors: HW
authors: Höpp
authors: V
authors: V
authors: Hombach
authors: H H
authors: HH
authors: Hilger
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D003327:Coronary Disease / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009203:Myocardial Infarction / Q000188:drug therapy
chemical_list: D003692:Delayed-Action Preparations; D007548:Isosorbide Dinitrate
vernacular_title: Diagnostik von Myokardischämien mit der Langzeitelektrokardiographie: Spontanvariabilität und Beeinflussbarkeit durch eine Nitrattherapie.