Maprotiline poisoning in a child.
A 6-year-old girl presented with tonic-clonic seizures and generalized convulsions lasting several minutes. A serum drug screen revealed maprotiline, and the estimated intake was 12 mg/kg. Despite initial neurologic impairment on discharge, follow-up 6 months later showed normal neurologic function in the patient. This report describes that case and discusses the toxicity associated with maprotiline and its management.
Peverini
R
R
Department of Pediatrics, Loma Linda University School of Medicine, CA 92350.
Ashwal
S
S
Petry
E
E
D000873:Anthracenes / Q000506:poisoning*; D001921:Brain / Q000187:drug effects; D002648:Child; D003131:Combined Modality Therapy; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008376:Maprotiline / Q000506:poisoning*; D009460:Neurologic Examination; D012640:Seizures / Q000139:chemically induced*; D013610:Tachycardia / Q000139:chemically induced*
D000873:Anthracenes; D008376:Maprotiline