title: Adrenomedullary origin of the hindquarter vasodilation during the transposition response of the rat.
abstract: Transposing a rat from the home cage to a new cage produces a cardiovascular response (transposition response) characterized by an increase in hindquarter blood flow with unchanged systemic arterial pressure. Arterial blood samples were collected from rats before and during this response for radioenzymatic assay of catecholamines. During the transposition response, the concentration of adrenaline and noradrenaline in plasma increased about six- and two-fold, respectively. Ablation of the adrenal medulla prevented these changes in plasma catecholamine concentration. Constant i.v. infusion of adrenaline, at rates producing a hindquarter flow approximately matching that observed during the transposition response, evoked an increase in plasma adrenaline concentration also approximately matching the increase observed during the transposition response. It is concluded that the increase in plasma adrenaline secreted from the adrenal medulla is the main cause of the increase in hindquarter blood flow in the transposition response.
authors: Department of Physiology, School of Medicine, University of Hiroshima, Japan.
authors: S
authors: S
authors: Sakata
authors: J
authors: J
authors: Iriuchijima
mesh_terms: D000313:Adrenal Medulla / Q000502:physiology*; D000818:Animals; D004837:Epinephrine / Q000097:blood / Q000494:pharmacology; D005260:Female; D006702:Homing Behavior; D008297:Male; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D014664:Vasodilation / Q000187:drug effects
chemical_list: D009638:Norepinephrine; D004837:Epinephrine