title: Transfer of enprofylline into breast milk.
abstract: Enprofylline concentrations were measured on 3 consecutive days in milk and plasma from six nursing mothers who were treated twice daily with 150-mg enprofylline slow-release tablets. The mean plasma concentration was 0.89 mg/L and the mean milk concentration was 0.71 mg/L, the average milk/plasma ratio being 0.80. The mean milk/plasma ratio ranged from 0.67 to 0.98 in the six mothers. It was estimated that a maximum of approximately 10% of an adult dose of enprofylline, on a per-kilogram body-weight basis, may be transferred to the suckling infant.
authors: Medical Department TA, Rigshospitalet, Copenhagen, Denmark.
authors: L C
authors: LC
authors: Laursen
authors: O
authors: O
authors: Borgå
authors: K
authors: K
authors: Ljungholm
authors: B
authors: B
authors: Weeke
mesh_terms: D000328:Adult; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D005260:Female; D006207:Half-Life; D006801:Humans; D008895:Milk, Human / Q000378:metabolism*; D014970:Xanthines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D014970:Xanthines; C034347:enprofylline