Hypophysectomy does not disturb the sleep-waking cycle in the cat.
The ablation of the hypophysis does not disturb the basic waking-sleep cycle. Further, this intervention fails to modify the recovery of sleep after instrumental paradoxical sleep deprivation as well as after injection of 5-hydroxytryptophan in parachlorophenylalanine-pretreated insomniac cats. These results demonstrate that the hypophysis does not play a significant role in sleep mechanisms. We discuss these data in view of a possible regulation of the sleep-waking cycle by hypothalamo-hypophyseal hormones.
Sallanon
M
M
Département de Médecine Expérimentale, Université Claude Bernard, INSERM U52, C.N.R.S. UA1195, Lyon, France.
Buda
C
C
Puymartin
M
M
Denoyer
M
M
Kitahama
K
K
Jouvet
M
M
D000818:Animals; D002415:Cats; D005260:Female; D007016:Hypophysectomy; D008297:Male; D010902:Pituitary Gland / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*