One stressful event blocks multiple actions of diazepam for up to at least a month.
Based on recent findings of this laboratory, the hypothesis was tested that a single stressful encounter might have a persistent antidiazepam influence. Our results indicate that one exposure to a brief stressful event up to at least one month earlier prevented completely the effect of diazepam on pentylenetetrazole-induced changes in dopamine in the rat frontal cortex, elevations of plasma corticosterone levels and seizures.
Antelman
S M
SM
Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, PA 15260.
Knopf
S
S
Kocan
D
D
Edwards
D J
DJ
Ritchie
J C
JC
Nemeroff
C B
CB
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D003975:Diazepam / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D008297:Male; D010146:Pain; D010433:Pentylenetetrazole / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*
D015102:3,4-Dihydroxyphenylacetic Acid; D003975:Diazepam; D004298:Dopamine; D010433:Pentylenetetrazole