The familial nature of multiple sclerosis: age-corrected empiric recurrence risks for children and siblings of patients.
Increasingly, MS patients ask neurologists about the risk that their close relatives will also develop MS. We calculated age-adjusted empiric recurrence risks from data on 815 index cases and over 3,000 of their siblings and children. In general, the risk for these relatives to develop MS is 3 to 5%, which is 30 to 50 times the 0.1% rate for the general population.
Sadovnick
A D
AD
Department of Medical Genetics, Health Sciences Centre Hospital, University of British Columbia, Vancouver, Canada.
Baird
P A
PA
D000367:Age Factors; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D012008:Recurrence; D012307:Risk Factors