Contribution of fat metabolism to 'glucoprivic' feeding produced by fourth ventricular 5-thio-D-glucose.
We examined whether manipulations of fat metabolism influence the feeding response to peripheral or central administration of 5-thio-D-glucose (5-TG), a potent inhibitor of glucose utilization. The increase in food intake produced by peritoneal (50 mg/kg) or fourth ventricular (50, 100, 150 micrograms) 5-TG was potentiated by administration of the fatty acid oxidation inhibitor, methyl palmoxirate (10 mg/kg, p.o.). In addition, rats maintained on a high-fat diet ate less in response to fourth ventricular 5-TG (150 micrograms) than did rats maintained on an equicaloric low-fat diet. These results suggest that the feeding response to 'glucoprivation' is determined by the interaction of glucose and fat oxidation.
Tordoff
M G
MG
Monell Chemical Senses Center, Philadelphia, PA 19104.
Flynn
F W
FW
Grill
H J
HJ
Friedman
M I
MI
D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D004852:Epoxy Compounds / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects*; D005947:Glucose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D011422:Propionates / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D004041:Dietary Fats; D004852:Epoxy Compounds; D007004:Hypoglycemic Agents; D011422:Propionates; C003002:5-thio-D-glucose; D005947:Glucose; C017522:methyl 2-tetradecylglycidate