title: Significance of maternal and infant serum antibodies to hepatitis B core antigen in hepatitis B virus infection of infancy.
abstract: The significance of IgM and IgG class antibodies to hepatitis B virus (HBV) core component (anti-HBc) was investigated in a study of maternal-fetal HBV transmission. An IgM anti-HBc response was lacking in the majority (49/53) of HBV-infected infants. This antibody thus cannot be used as an indicator of transplacental infection. However, most infants who became HBsAg positive during the first 6 months of life acquire infection in the perinatal period rather than transplacentally. Passively transferred maternal IgG anti-HBc in the infant and additional IgM anti-HBc positively in the carrier mother have no modulating influence on HBV infection of infants born to HBV carrier women.
authors: Department of Pathology, All-India Institute of Medical Sciences, New Delhi.
authors: S K
authors: SK
authors: Panda
authors: M K
authors: MK
authors: Bhan
authors: D K
authors: DK
authors: Guha
authors: A
authors: A
authors: Gupta
authors: R
authors: R
authors: Datta
authors: A J
authors: AJ
authors: Zuckerman
authors: N C
authors: NC
authors: Nayak
mesh_terms: D000367:Age Factors; D002353:Carrier State / Q000276:immunology / Q000635:transmission; D005260:Female; D006509:Hepatitis B / Q000151:congenital / Q000276:immunology / Q000635:transmission*; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
chemical_list: D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M