title: Cholera toxin neutralization: a comparison of purified serum IgG and biliary secretory IgA antibodies.
abstract: Rats were immunized three times with cholera toxin via the intraintestinal or intravenous route, and their respective biliary secretory IgA (sIgA) or serum IgG antibodies were affinity-purified on a cholera toxin immunoabsorbent. On a molar basis, the sIgA antibodies were roughly seven-fold more efficient than IgG antibodies in neutralizing cholera toxin in the ligated intestinal loop assay. Various explanations for this difference in neutralizing capacity are proposed.
authors: Catholic University of Louvain, International Institute of Cellular and Molecular Pathology, Brussels, Belgium.
authors: P
authors: P
authors: Pierre
authors: A
authors: A
authors: Langendries
authors: J P
authors: JP
authors: Vaerman
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D001646:Bile / Q000276:immunology*; D002772:Cholera Toxin / Q000008:administration & dosage / Q000276:immunology*; D004386:Duodenum; D007114:Immunization / Q000379:methods; D007071:Immunoglobulin A, Secretory / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D007267:Injections; D007275:Injections, Intravenous; D008297:Male; D009500:Neutralization Tests; D051381:Rats; D014734:Vibrio cholerae / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D002772:Cholera Toxin