Effect of peroxisome proliferating hypolipidemic agents on serum activity levels of arylesterase and cholinesterase in rats and mice.
The effect of dietary exposures to peroxisome-proliferating, hypolipidemic agents on serum esterases was determined in rats and mice. Four genotypes of mice were fed nafenopin (1000 ppm) for six weeks and clofibrate (5000 ppm) was fed to young and aged rats for three weeks. The exposures significantly increased serum cholinesterase activity levels and decreased serum arylesterase activity levels in all groups of both species.
Butler
E G
EG
American Health Foundation, Valhalla, New York 10595.
England
P J
PJ
Williams
G M
GM
D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D002802:Cholinesterases / Q000097:blood*; D002994:Clofibrate / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D008830:Microbodies / Q000187:drug effects*; D009255:Nafenopin / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D013045:Species Specificity
D000960:Hypolipidemic Agents; D009255:Nafenopin; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D002802:Cholinesterases; D002994:Clofibrate