Repeat radiation synovectomy with dysprosium 165-ferric hydroxide macroaggregates in rheumatoid knees unresponsive to initial injection.
Because of failure to fully respond to an initial intraarticular injection of dysprosium 165-ferric hydroxide macroaggregates, 17 patients with seropositive rheumatoid arthritis underwent repeat radiation synovectomy using this agent. Of the 13 patients who were evaluated 1 year later, 54% (7 knees) had good results, 31% (4 knees) had fair results, and 15% (2 knees) had poor results. The initial lack of significant benefit from radiation synovectomy did not appear to preclude a favorable response to a second injection.
Vella
M
M
Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
Zuckerman
J D
JD
Shortkroff
S
S
Venkatesan
P
P
Sledge
C B
CB
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000503:physiopathology / Q000532:radiotherapy*; D004419:Dysprosium / Q000008:administration & dosage / Q000627:therapeutic use*; D005069:Evaluation Studies as Topic; D005290:Ferric Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint; D008875:Middle Aged; D010146:Pain; D011868:Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*; D012008:Recurrence; D013583:Synovial Membrane; D014680:Veins
D005290:Ferric Compounds; D011868:Radioisotopes; D004419:Dysprosium; C021024:ferric hydroxide