Effect of clavulanic acid on the susceptibility of clinical anaerobic bacteria to ticarcillin: a multicenter study.
Over 2,000 recent clinical isolates of anaerobic bacteria were tested at five medical centers for susceptibility to ticarcillin, ticarcillin plus clavulanic acid, clindamycin, and metronidazole. At 64 micrograms/ml, ticarcillin inhibited 92% of all isolates, but 98% were inhibited at this concentration when 2 micrograms/ml of clavulanic acid was added. With different Bacteroides species, clavulanic acid reduced ticarcillin MICs 2- to 32-fold; other anaerobic species were not significantly affected.
Fuchs
P C
PC
Department of Pathology, St. Vincent Hospital and Medical Center, Portland, OR 97225.
Jones
R N
RN
Barry
A L
AL
Allen
S D
SD
Aldridge
K E
KE
Gerlach
E H
EH
Sommers
H M
HM
D001421:Bacteria, Anaerobic / Q000187:drug effects*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology; D004357:Drug Synergism; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D013982:Ticarcillin / Q000494:pharmacology*
D002969:Clavulanic Acids; D010406:Penicillins; D008795:Metronidazole; D019818:Clavulanic Acid; D002981:Clindamycin; D013982:Ticarcillin