Mitral or aortic regurgitation: quantification of regurgitant volumes with cine MR imaging.
A new, rapid magnetic resonance (MR) imaging method, cine MR imaging, was used to determine the regurgitant fraction (RF) in patients with left-sided regurgitant lesions. Right and left ventricular stroke volumes were determined with cine MR imaging and a modified Simpson formula in ten healthy volunteers and 23 patients known to have either predominant mitral (n = 17) or aortic (n = 6) regurgitation. RFs evaluated at cine MR imaging were compared in healthy persons and patients with mild, moderate, or severe regurgitation demonstrated at angiography (n = 10) and Doppler echocardiography (n = 13). Cine MR imaging depicted regurgitant blood flow in all 29 regurgitant lesions in 23 patients as areas of low signal intensity within the regurgitant chamber. The RF was 4% +/- 7% in healthy subjects and 12% +/- 12% in those with mild, 35% +/- 14% in those with moderate, and 63% +/- 5% in those with severe regurgitation. The RFs determined by two observers were similar.
Sechtem
U
U
Department of Radiology, University of California School of Medicine, San Francisco 94143.
Pflugfelder
P W
PW
Cassidy
M M
MM
White
R D
RD
Cheitlin
M D
MD
Schiller
N B
NB
Higgins
C B
CB
D000328:Adult; D000368:Aged; D001022:Aortic Valve Insufficiency / Q000503:physiopathology*; D004452:Echocardiography; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000503:physiopathology*; D009040:Motion Pictures; D013318:Stroke Volume