LL-F28249 antibiotic complex: a new family of antiparasitic macrocyclic lactones. Isolation, characterization and structures of LL-F28249 alpha, beta, gamma, lambda.
A new family of antiparasitic macrolides has been isolated from Streptomyces cyaneogriseus sp. noncyanogenus. The compounds, designated LL-F28249 alpha, beta, gamma and lambda, possess potent antiparasitic activity. The isolation, purification and structure determination by spectroscopic methods are presented.
Carter
G T
GT
Medical Research Divisio, Lederle Laboratories, American Cyanamid Co., Pearl River, N.Y. 10965.
Nietsche
J A
JA
Hertz
M R
MR
Williams
D R
DR
Siegel
M M
MM
Morton
G O
GO
James
J C
JC
Borders
D B
DB
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D000969:Antinematodal Agents / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D007783:Lactones / Q000302:isolation & purification*; D018942:Macrolides; D010272:Parasitic Diseases / Q000188:drug therapy; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000969:Antinematodal Agents; D007783:Lactones; D018942:Macrolides; C056044:LL-F 28249lambda; C056041:nemadectin