title: Metabolism of sennosides by human intestinal bacteria.
abstract: During the course of studies on the metabolism of sennosides by human intestinal bacteria, an enzyme which takes part in the reduction of sennosides and sennidins was originally isolated from Peptostreptococcus intermedius. This enzyme catalyzed the electron transfer from NADH to FAD, FMN or benzyl viologen, which reduced nonenzymatically sennosides and sennidins to 8-glucosyl-rhein anthrone and rhein anthrone, respectively.
authors: Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Japan.
authors: M
authors: M
authors: Hattori
authors: T
authors: T
authors: Namba
authors: T
authors: T
authors: Akao
authors: K
authors: K
authors: Kobashi
mesh_terms: D000880:Anthraquinones / Q000378:metabolism*; D001421:Bacteria, Anaerobic / Q000378:metabolism*; D004579:Electron Transport; D005243:Feces / Q000382:microbiology; D005182:Flavin-Adenine Dinucleotide / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology*; D010084:Oxidation-Reduction; D010462:Peptostreptococcus / Q000201:enzymology; D012676:Senna Extract; D000081226:Sennosides
chemical_list: D000880:Anthraquinones; D000081226:Sennosides; D005182:Flavin-Adenine Dinucleotide; D012676:Senna Extract