Conditional analgesia, defensive freezing, and benzodiazepines.
When rats are placed in a situation that has come to be associated with footshock through the process of Pavlovian conditioning, they react with the species-specific defensive response of freezing and a reduction in sensitivity to painful stimulation. In the present experiments, the effects of three benzodiazepines on both of these responses were examined. Pain sensitivity was measured with the formalin test. Concurrent observations of formalin-induced recuperative behavior and freezing were recorded while the animals were in the presence of shock-associated contextual stimuli. It was found that midazolam (Experiments 1 and 2), chlordiazepoxide (Experiment 3), and diazepam (Experiment 4) were capable of significantly attenuating the conditional analgesia. Midazolam and diazepam also reduced the freezing response. The finding that these anxiolytic agents attenuate both conditional responses suggests that the freezing and analgesia are mediated by a common fearlike process.
Fanselow
M S
MS
Department of Psychology, Dartmouth College, Hanover, New Hampshire 03755.
Helmstetter
F J
FJ
D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D003565:Cytidine Diphosphate / Q000494:pharmacology; D003674:Defense Mechanisms / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D005239:Fear / Q000187:drug effects / Q000502:physiology*; D005260:Female; D008874:Midazolam / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D012768:Shivering / Q000187:drug effects*
D001569:Benzodiazepines; D003565:Cytidine Diphosphate; D003975:Diazepam; D008874:Midazolam