A new immunomodulator, FR-900483.
FR-900483 is a new immunoactive substance produced by a fungus, Nectria lucida F-4490. Concanavalin A-stimulated lymphocyte proliferation, which had been suppressed by addition of immunosuppressive factor, was restored to a normal level by the addition of FR-900483. Furthermore, FR-900483 restored the capacity of immunosuppressed mice to produce antibody against sheep red blood cells.
Shibata
T
T
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Nakayama
O
O
Tsurumi
Y
Y
Okuhara
M
M
Terano
H
H
Kohsaka
M
M
D000276:Adjuvants, Immunologic / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D006023:Glycoproteins / Q000494:pharmacology; D006999:Hypocreales / Q000145:classification / Q000378:metabolism; D050113:Imino Furanoses; D051379:Mice; D009363:Neoplasm Proteins; D011759:Pyrrolidines / Q000302:isolation & purification*
D000276:Adjuvants, Immunologic; D006023:Glycoproteins; D050113:Imino Furanoses; D009363:Neoplasm Proteins; D011759:Pyrrolidines; C038588:serum immunosuppressive factor, human; C055825:nectrisine