[Effectiveness of using cavinton in patients of different ages with chronic forms of cerebrovascular diseases (clinico-rheographic research)].
A total of 171 patients of young, middle, and old age presenting initial manifestations of cerebral circulatory insufficiency and early disordered-circulatory encephalopathy were treated with cavinton. The clinical effect of the drug mostly expressed in a considerable decrease of subjective manifestations of the disease was fairly high in most patients of different age groups. The most pronounced positive shifts (according to REG) of the cerebral hemodynamics upon cavinton therapy were observed in young and middle-aged patients. A lower efficacy in elderly patients was explained by the fact that there were grave organic changes in the cerebral vessels, predominantly in those of small and medium caliber. A comprehensive nature of the drug action, as well as the absence of any adverse effect on the cerebral hemodynamics recommend cavinton as a drug of choice in the treatment of patients with chronic forms of cerebral ischemia, including elderly ones. The drug should not be administered to patients over 60 years of age with marked disorders of cardiac activity.
Burtsev
E M
EM
Shprakh
V V
VV
Savkov
V S
VS
D000368:Aged; D000375:Aging / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000209:etiology; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D002537:Intracranial Arteriosclerosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D010992:Plethysmography, Impedance; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D014748:Vinca Alkaloids / Q000008:administration & dosage / Q000627:therapeutic use*
D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C013983:vinpocetine
Ob éffektivnosti primeneniia kavintona u bol'nykh raznogo vozrasta s khronicheskimi formami tserebrovaskuliarnykh zabolevaniĭ (kliniko-reograficheskoe issledovanie).