title: A statistical examination of self-ordering of amino acids in proteins.
abstract: Steinman and Cole (1967) have claimed that amino acids will naturally assume a nonrandom sequence when polymerized into polypeptides. They based their claim on a comparison of the frequency with which various dipeptide bonds formed in a dilute solution of amino acids to the various depeptide frequencies actually observed in ten proteins. Although the trends in the normalized frequencies go in the same direction, a statistical examination of the two sets of frequencies indicates that there is no correlation at all between experimental dipeptide frequencies and actual depeptide frequencies based on the chi-square tests.
authors: Dept. of Chemistry, Millikin University, Decatur, IL 62522.
authors: R A
authors: RA
authors: Kok
authors: J A
authors: JA
authors: Taylor
authors: W L
authors: WL
authors: Bradley
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids; D004151:Dipeptides; D008962:Models, Theoretical; D011506:Proteins; D012984:Software
chemical_list: D000596:Amino Acids; D004151:Dipeptides; D011506:Proteins