title: Effect of altered masticatory function on [3H]-thymidine and [35S]-sulfate incorporation in the condylar cartilage of the rat.
abstract: The response of the condylar cartilage to alterations in compressive joint reaction forces in vivo has been little studied. In an attempt to reduce or eliminate the occlusal forces resulting from mastication or incision, male weanling rats were fed a soft diet requiring little chewing and/or had their incisors clipped every other day. Incorporation (dpm/micrograms DNA) of [3H]-thymidine and [35S]-sulfate was significantly decreased relative to controls in the incisor-clipped group, but not in the soft-diet group. Animals having both treatments also exhibited significantly lower incorporation values than controls, suggesting the importance of incision for loading at the mandibular joint. These data corroborate in vitro studies which suggest that compressive forces can affect mitotic activity and synthesis of proteoglycans in the condylar cartilage. However, additional factors, both hormonal and biomechanical in nature, may be important in the in vivo environment.
authors: Department of Anatomy, Baylor College of Dentistry, Dallas, Tex.
authors: R J
authors: RJ
authors: Hinton
mesh_terms: D000818:Animals; D001345:Autoradiography; D002356:Cartilage / Q000000981:diagnostic imaging / Q000378:metabolism*; D008335:Mandibular Condyle / Q000000981:diagnostic imaging / Q000378:metabolism*; D008409:Mastication; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013431:Sulfates / Q000378:metabolism*; D013462:Sulfur Radioisotopes; D013936:Thymidine / Q000378:metabolism*; D014316:Tritium
chemical_list: D013431:Sulfates; D013462:Sulfur Radioisotopes; D014316:Tritium; D013936:Thymidine