title: Raised plasma thromboxane B2 levels in experimental acute necrotizing pancreatitis in rats. The effects of flunarizine, dazoxiben, and indomethacin.
abstract: The possible role of thromboxane A2 (TXA2) in acute necrotizing pancreatitis (ANP) was investigated in rats. After ANP was induced by injecting sodium taurocholate (5% w/v) into the pancreatic duct, the thromboxane B2 (TXB2) levels in plasma increased significantly. The effects of indomethacin, a general blocker of prostaglandin synthesis, on survival time and on plasma TXB2 levels were compared with those of dazoxiben, a more specific blocker of TXA2 synthesis, and Flunarizine, a calcium entry blocker known to inhibit the effects of TXA2. In a test group without any treatment, all animals died within 30 h of ANP induction. Although TXB2 levels were lowered by the administration of indomethacin, dazoxiben, and Flunarizine, survival times were not significantly altered. Indomethacin pretreatment had no beneficial effect, whereas 30% and 40% of the animals survived for 36 h after treatment with Flunarizine and dazoxiben, respectively. The results of the present study indicate that inhibition of TXA2 synthesis alone does not dramatically alter survival time. However, a potential role for other arachidonate metabolites in ANP cannot be ruled out by this study.
authors: Dept. of Experimental Surgery, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands.
authors: B
authors: B
authors: van Ooijen
authors: R J
authors: RJ
authors: Ouwendijk
authors: W J
authors: WJ
authors: Kort
authors: F J
authors: FJ
authors: Zijlstra
authors: J E
authors: JE
authors: Vincent
authors: J H
authors: JH
authors: Wilson
authors: D L
authors: DL
authors: Westbroek
mesh_terms: D000208:Acute Disease; D000818:Animals; D005444:Flunarizine / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D009336:Necrosis; D010195:Pancreatitis / Q000097:blood* / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors; D013929:Thromboxane B2 / Q000097:blood*
chemical_list: D007093:Imidazoles; C029166:dazoxiben; D013929:Thromboxane B2; D013928:Thromboxane A2; D005444:Flunarizine; D007213:Indomethacin