Chemical modification of steffimycin B.
Fifteen 3-substituted analogues of steffimycin B (1) have been synthesized and their activity against P388 murine leukemia has been determined. Three of these were substantially more active than the parent compound.
Wiley
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Research Laboratories, Upjohn Company, Kalamazoo, Michigan 49001.
Elrod
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Harper
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D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy; D009279:Naphthacenes / Q000494:pharmacology; D013329:Structure-Activity Relationship
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; C009944:steffimycin