5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue.
The enzymatic release of 5-hydroxymethylcytosine from T2 bacteriophage DNA was effected by an extract of calf thymus. Like the previously described 5-hydroxymethyluracil DNA glycosylase, 5-hydroxymethylcytosine DNA glycosylase was not detectable in bacterial extracts. The phylogenetic distribution of these activities indicates that their primary function is the maintenance of methylcytosine residues in differentiated tissue.
Cannon
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SV
Department of Pathology, New York University School of Medicine, New York, NY 10016.
Cummings
A
A
Teebor
G W
GW
D044503:5-Methylcytosine / Q000031:analogs & derivatives; D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D003596:Cytosine / Q000031:analogs & derivatives* / Q000378:metabolism; D045647:DNA Glycosylases; D004279:DNA, Viral / Q000378:metabolism; D009699:N-Glycosyl Hydrolases / Q000378:metabolism*; D013604:T-Phages / Q000235:genetics; D013950:Thymus Gland / Q000201:enzymology
D004279:DNA, Viral; C011865:5-hydroxymethylcytosine; D044503:5-Methylcytosine; D003596:Cytosine; D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases