Comparison of the recovery characteristics of diazepam and midazolam.
A double-blind crossover comparison of efficacy and recovery from midazolam 5 mg and diazepam (in propylene glycol) 10 mg was undertaken in eight volunteer subjects. It was found that midazolam was significantly more potent in this dose ratio than diazepam, helping to explain the finding of previous studies that the recovery from midazolam and diazepam in a 1:2 dose ratio is comparable.
Galletly
D
D
Department of Anaesthesia, Wellington Clinical School of Medicine, New Zealand.
Forrest
P
P
Purdie
G
G
D000328:Adult; D003975:Diazepam / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008874:Midazolam / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D013997:Time Factors
D006993:Hypnotics and Sedatives; D003975:Diazepam; D008874:Midazolam