cis-Halovinylthioacetamido side chain, a new effective structural element for 7 beta-substitution in cephem and oxacephem antibiotics. I. 7 beta-cis-Chlorovinylthioacetamino-7 alpha-methoxy-1-oxacephems.
The synthesis and in vitro activity of 7 beta-(substituted vinylthioacetamido)-1-oxacephem antibiotics are described. The compounds having a cis-chlorovinylthioacetamido group at C-7 showed high activity against Gram-positive as well as Gram-negative bacteria. The most interesting compound of the series was 51 I because of its high activity and high plasma level in mice.
Nishitani
Y
Y
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Aoki
T
T
Yoshida
T
T
Nagata
W
W
D009070:Moxalactam / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D009070:Moxalactam