Milk transfer of rhein in the rhesus monkey.
A HPLC method was developed to measure rhein, a laxatively active metabolite of sennosides A + B, in milk and plasma. Samples from 2 lactating rhesus monkeys were taken over 48 h after oral administration of sennosides (1 mg kg-1). Detectable rhein levels were found in plasma between 2 and 12 h and in milk between 4 and 12 h after administration, but rhein excretion in milk seems to be far below the dose necessary to elicit a laxative effect in the suckling offspring.
Cameron
B D
BD
Department of Metabolism and Pharmacokinetics, Inveresk Research International, Musselburgh, UK.
Phillips
M W
MW
Fenerty
C A
CA
D000818:Animals; D000880:Anthraquinones / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D002400:Cathartics / Q000493:pharmacokinetics; D005260:Female; D007774:Lactation / Q000378:metabolism; D008253:Macaca mulatta; D008892:Milk / Q000378:metabolism*; D011247:Pregnancy; D012676:Senna Extract; D000081226:Sennosides
D000880:Anthraquinones; D002400:Cathartics; D000081226:Sennosides; D012676:Senna Extract; C020491:rhein