Effect of arteriovenous shunting on plasma vasopressin levels in the anesthetized dog.
Studies were performed in dogs anesthetized with chloralose to establish the plasma arginine vasopressin (AVP) response to 30-minute periods of femoral arteriovenous (AV) shunting at levels of either 10%, 30%, or 50% of control cardiac output. Significant increases in cardiac output, heart rate, and total body peripheral resistance (shunt resistance excluded), suggesting decreased sinoaortic baroreceptor activity, occurred at shunt fractions greater than 10%. There were no significant changes in plasma concentrations of AVP at any level of AV shunting. In separate studies, significant elevations in plasma AVP levels were observed in vagotomized dogs during AV shunting of 50% of control cardiac output. These results indicate that AV shunting less than or equal to 50% of cardiac output does not acutely alter plasma AVP levels in the intact dog and that cardiopulmonary receptors with vagal afferents suppress AVP release that might otherwise occur in this canine model of AV shunting.
Sklar
A H
AH
Department of Medicine, Medical College of Georgia, Augusta 30912-2623.
Bond
G C
GC
Lightfoot
B
B
Fowler
B
B
Ginsburg
J
J
D000758:Anesthesia; D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood*; D001166:Arteriovenous Shunt, Surgical; D001794:Blood Pressure; D002302:Cardiac Output; D004285:Dogs; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics; D008297:Male; D014628:Vagotomy; D014655:Vascular Resistance
D001127:Arginine Vasopressin