DNA aneuploidy in solitary colonic adenomas and the future risk of colorectal cancer.
Flow cytometric DNA analysis was performed on the colonic adenomas of 24 patients who had resection of an invasive colorectal carcinoma subsequent to polypectomy. The incidence of DNA aneuploidy among these adenomas was only 13 percent. Thus, simple recognition of colonic adenomas as being DNA diploid or DNA aneuploid is unlikely to be helpful for identifying patients with adenoma who are at high risk for developing a future colorectal carcinoma.
Scott
N A
NA
Section of Colon and Rectal Surgery, Mayo Clinic, Rochester, Minnesota 55905.
Weiland
L H
LH
Dozois
R R
RR
Beart
R W
RW
Lieber
M M
MM
D000782:Aneuploidy; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology; D003111:Colonic Polyps / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics*; D004171:Diploidy; D005434:Flow Cytometry; D006801:Humans; D012307:Risk Factors
D004273:DNA, Neoplasm