A semiiterative method for derivation of concentration-response parameters.
A method for the analysis of concentration-response curves is described. The parameters of these curves, namely, maximal response, apparent affinity, and slope factor, are calculated by means of a semiiterative approach using a microcomputer. Considerably less computer processing time is required than with other iterative nonlinear curve fitting methods. The method is particularly helpful in cases in which accurate observation of maximal response is limited.
Onaran
H O
HO
Department of Pharmacology, Ankara University, Turkey.
Tuncali
T
T
Bökesoy
T A
TA
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D008838:Microcomputers; D011725:Pyridines / Q000494:pharmacology; D011817:Rabbits; D012984:Software
D011725:Pyridines; C006183:2-(2-aminoethyl)pyridine