Buccal absorption of drugs: an in vivo measurement of their innate lipophilicity.
The area under the curve of the buccal absorption of drugs against pH (AUC) is significantly correlated with their pH-dependent renal excretion, and protein binding. Therefore, AUC may be considered as an in vivo model for the quantitative measurement of innate lipophilicity and passage of drugs across lipid membranes.
Randhawa
M A
MA
Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, England.
Turner
P
P
D000278:Administration, Buccal; D002610:Cheek / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D008055:Lipids; D010599:Pharmacokinetics; D012995:Solubility
D008055:Lipids