title: Ultrastructural alterations in caudate nucleus in aged cats.
abstract: These studies provide information on the changes in the ultrastructure in the caudate nucleus of aged cats. The major finding was that there was a decrease in the density of synapses in caudate neuropil. This decrease occurred in animals after 3 years of age and remained relatively constant in older animals. In conjunction with this change a population of unusually long synapses also occurred. These larger synaptic appositions were associated with enlarged spine heads. The caudate also showed a number of qualitative ultrastructural alterations. Many neurons contained accumulations of lipofuscin or lipopigment granules in aged animals. These inclusions occurred in both soma and dendrites of neurons and all types of glial cells. A unique configuration of collapsed agranular cisterns also was observed in aged animals. The present results indicate that decreases in synaptic density may be one morphological event underlying functional alterations observed in caudate neurons in aged cats.
authors: Mental Retardation Research Center, University of California, Los Angeles 90024.
authors: M S
authors: MS
authors: Levine
authors: A M
authors: AM
authors: Adinolfi
authors: R S
authors: RS
authors: Fisher
authors: C D
authors: CD
authors: Hull
authors: D
authors: D
authors: Guthrie
authors: N A
authors: NA
authors: Buchwald
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D002415:Cats; D002421:Caudate Nucleus / Q000254:growth & development* / Q000648:ultrastructure; D002452:Cell Count; D008854:Microscopy, Electron; D013569:Synapses / Q000502:physiology* / Q000648:ultrastructure