title: Relative bioavailability of the hydrochloride, sulphate and ethyl carbonate salts of quinine.
abstract: The hydrochloride, sulphate and ethylcarbonate salts of quinine were given in single oral doses (600 mg base equivalent) to nine healthy male subjects according to a cross-over design. No statistically significant differences were noted in the plasma drug concentration-time profiles although inter- and intra-subject variation in AUC, Cmax and tmax values was appreciable. The ethylcarbonate salt may be preferred for use in paediatric patients because of its neutral taste.
authors: National Drug Research Centre, Universiti Sains Malaysia, Penang.
authors: A
authors: A
authors: Jamaludin
authors: M
authors: M
authors: Mohamad
authors: V
authors: V
authors: Navaratnam
authors: K
authors: K
authors: Selliah
authors: S C
authors: SC
authors: Tan
authors: W H
authors: WH
authors: Wernsdorfer
authors: K H
authors: KH
authors: Yuen
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D006801:Humans; D006851:Hydrochloric Acid; D008297:Male; D011803:Quinine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012492:Salts; D013431:Sulfates
chemical_list: D012492:Salts; D013431:Sulfates; D011803:Quinine; D006851:Hydrochloric Acid