title: [The stability of bromhexine and the structure of its degradation products].
abstract: Refluxed acid or neutral aqueous solutions of Bromhexine (1) show four degradation products. 1 is decomposed at room temperature (20 degrees C; 1 year) less than 1%. Degradation products of crystalline 1 are not detectable in the temperature-moisture-test. Under normal storage conditions a 5-year stability for aqueous solutions and a more than 10-year stability for crystalline 1 are estimated. Very small amounts of three degradation products were isolated by TLC. According to MS-, UV- and IR-analysis their structures are 3-cyclohexyl-6,8-dibromo-chinazoline-4-one (2a), 3-cyclohexyl-6,8-dibromo-chinazoline (2b) and 3-amino-4,6-dibromo-benzaldehyde (3). The structure of N-Methylcyclohexylamine is supposed for a further product. Ms fragmentation and degradation mechanisms are discussed.
authors: Wissenschaftsbereich Pharmazie, Humboldt-Universität zu Berlin.
authors: B
authors: B
authors: Göber
authors: H
authors: H
authors: Lisowski
authors: P
authors: P
authors: Franke
mesh_terms: D001964:Bromhexine / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001964:Bromhexine
vernacular_title: Zur Stabilität von Bromhexin und zur Struktur seiner Abbauprodukte.