title: Genetic-associated resistance to foot rot in selected Targhee sheep.
abstract: Three Targhee rams obtained from the Ohio Agricultural and Experimental Station had been identified as foot rot resistant on the basis of results of challenge exposure. In the first breeding trial, when rams were bred to 20 foot rot-susceptible ewes, the percentages of foot rot-resistant offspring from the 3 foot rot-resistant rams were 68, 82, and 100, compared with 55 and 60 for foot rot-resistant offspring from 2 known foot rot-susceptible rams. In the second year, the foot rot-resistant rams were mated with ewes of unknown foot rot status. The foot rot-resistant status of their lambs was compared with that of range-raised lambs whose parents' foot rot status was unknown. During the first year, challenge exposure to the disease consisted of confinement of the lambs in moist or wet pens with sheep affected with the naturally acquired disease. This protocol was repeated for lambs born during the second-year breeding trial. In addition, the right front foot of each lamb was inoculated with a broth culture of Bacteroides nodosus. During the second year, when data that included infected feet from all lambs were analyzed, 41% of the progeny of the foot rot-resistant rams and 17% of the offspring of parents of unknown foot rot status were unaffected by the disease. When the B nodosus-inoculated foot was not included in the analysis, however, 61% of the progeny of the foot rot-resistant rams and 29% of the others were unaffected. The resistance to foot rot undoubtedly is hereditary. The mechanism of resistance may be in the interdigital skin.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Caldwell Veterinary Teaching Center, University of Idaho, Caldwell 83605.
authors: M S
authors: MS
authors: Bulgin
authors: S D
authors: SD
authors: Lincoln
authors: C F
authors: CF
authors: Parker
authors: P J
authors: PJ
authors: South
authors: J J
authors: JJ
authors: Dahmen
authors: V M
authors: VM
authors: Lane
mesh_terms: D000818:Animals; D004198:Disease Susceptibility; D005260:Female; D005535:Foot Rot / Q000235:genetics*; D007113:Immunity, Innate; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000235:genetics*