Chymostatin has no apparent beneficial effect on muscular dystrophy in the mdx mouse.
The effect of the cathepsin B inhibitor chymostatin was studied in mice with an X chromosome-linked muscular dystrophy. Treatment for 7 weeks at a daily dose of 1 microgram/g body weight had no apparent beneficial effect: serum creatine kinase levels, histopathology and the activity of muscle cathepsin B were not significantly altered by the treatment.
Christie
K N
KN
Department of Anatomy, The University, Dundee, Scotland, U.K.
D000818:Animals; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009137:Muscular Dystrophy, Animal / Q000188:drug therapy*; D009842:Oligopeptides / Q000627:therapeutic use*
D009842:Oligopeptides; C002101:chymostatin; D002918:Chymotrypsin