Chromosome abnormalities in peripheral blood lymphocytes from untreated Hodgkin's patients. A possible evidence for chromosome instability.
We describe the presence of a high frequency of spontaneous chromosome aberrations in lymphocytes from six untreated patients with Hodgkin's disease. The characteristics of the chromosome abnormalities observed suggest the existence of a certain degree of chromosome instability in these cases, that could be a predisposing factor for the development of malignancies.
Barrios
L
L
Departament de Biologia Cel.lular i Fisiologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Caballín
M R
MR
Mirò
R
R
Fuster
C
C
Berrozpe
G
G
Subías
A
A
Batlle
X
X
Egozcue
J
J
D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged