Variations in c-fos gene expression during rat brain development.
Expression of the c-fos proto-oncogene has been associated with mitosis or differentiation in a number of tissue culture model systems. We have studied the expression of this gene during in vivo brain development in the rat. Our results demonstrate that very low levels of c-fos mRNA are detectable during the period of development characterized by rapid mitosis, whereas much higher concentrations of c-fos mRNA are found in the brains of older neonatal animals and adults. Therefore, although c-fos could be participating in the regulation of mitosis during early postnatal development of the brain, it is also likely to play an important role in mature brain tissue.
Gubits
R M
RM
Division of Molecular Biology, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962.
Hazelton
J L
JL
Simantov
R
R
D000375:Aging; D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development* / Q000502:physiology; D004553:Electric Conductivity; D005314:Embryonic and Fetal Development; D009928:Organ Specificity; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000502:physiology; D014158:Transcription, Genetic
D012333:RNA, Messenger