Gestational aspects of uterus didelphys.
The reproductive history was analyzed of 13 women with a laparoscopic or laparotomy diagnosis of uterus didelphys and followed for two to six years. Two patients (15.4%) presented with primary infertility; the other 11 had a total of 27 pregnancies, the outcome of which was spontaneous abortion in 20 cases (74%), premature labor in 6 (22.2%) and term birth in 1 (3.7%), with a live birth rate of 18.5%. Metroplasty was performed in five cases, with live birth in three, spontaneous abortion in 1 and no postoperative conceptions in one. Cervical cerclage was performed in only one case and bilateral ovarian resection in one. The live birth rate, considering all pregnancies before and after treatment, was 35%. The compromised fertility of the uterus didelphys is probably attributable to congenital alterations in vascularization that may have a negative influence on developmental phases following implantation, particularly the structuralization of the fetomaternal relations that precede placentation.
Fedele
L
L
First Department of Obstetrics and Gynecology, University of Milan, Italy.
Zamberletti
D
D
D'Alberton
A
A
Vercellini
P
P
Candiani
G B
GB
D000328:Adult; D005260:Female; D005298:Fertility; D006801:Humans; D007247:Infertility, Female / Q000196:embryology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D011446:Prospective Studies; D012189:Retrospective Studies; D014599:Uterus / Q000002:abnormalities* / Q000601:surgery