Responses of phasic and tonic hippocampal theta-on cells to cholinergics: differential effects of muscarinic and nicotinic activation.
The discharge patterns of tonic and phasic hippocampal formation theta-on cells were recorded in response to systemic administration of cholinergic agents, in urethane-anesthetized rats. Eserine and carbachol resulted in long trains of slow-wave theta and accompanying activation of tonic and phasic theta-on cells. Both slow-wave theta and the characteristic accompanying discharge patterns of theta-on cells were blocked by administration of atropine SO4, providing evidence that the effects of eserine and carbachol were mediated by muscarinic receptors. The systemic administration of nicotine resulted in 20-30 s of slow-wave theta and during this time, both tonic and phasic theta-on cell discharges were suppressed.
Bland
B H
BH
Department of Psychology, University of Calgary, Alta, Canada.
Colom
L V
LV
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology*; D004553:Electric Conductivity; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats
D009538:Nicotine; D001285:Atropine; D002217:Carbachol; D010830:Physostigmine