Interstrain differences in the responsiveness of mice to glucan with respect to hematological effects and manifestations of late damage.
A study was made of the effect of a single s.c. injection of 4 mg glucan in the mouse strains C57BL/10, C3H and a hybrid population of mice. In mice of the strain C57BL/10 high responsiveness was demonstrated, manifested in a long-term increase in the granulocyte counts in the peripheral blood. These effects were accompanied by a fall in the mean red cell volume and the mean corpuscular hemoglobin, a fall in body weight, and mortality. 10 weeks after administration of glucan histology revealed necrotic foci in the livers of animals of the C57BL/10 strain, and an increased amount of the fibrous connective component in the pulmonary interstitium. The strain C3H exhibited a low responsiveness in respect of the hematological indices, while the hybrids did not show any significant response.
Pospísil
M
M
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
Tkadlecek
L
L
Netíková
J
J
Pipalová
I
I
Viklická
S
S
Kozubik
A
A
Vácha
J
J
Jarý
J
J
D000818:Animals; D001773:Blood Cells / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004909:Erythrocyte Indices / Q000187:drug effects; D004911:Erythrocyte Volume / Q000187:drug effects; D005936:Glucans / Q000633:toxicity*; D006098:Granulocytes / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity; D013997:Time Factors
D005936:Glucans