Local control of recurrent clival and sacral chordoma after interstitial irradiation with iodine-125: new techniques for treatment of recurrent or unresectable chordomas.
Using new 125I brachytherapy techniques, we were able to deliver safely a tumor volume dose of 16,000 rads to a previous irradiated, large, recurrent sacral chordoma by means of the intraoperative interstitial implantation of 229 low activity 125I seeds and 40,000 rads to a previously irradiated, small, recurrent clival chordoma by means of the transnasal needle implantation of two high activity 125I seeds. Iodine-125 brachytherapy was followed by regression of tumor, lessening of symptoms, and bony recalcification in both cases.
Kumar
P P
PP
Division of Radiation Oncology, University of Nebraska College of Medicine, Omaha.
Good
R R
RR
Skultety
F M
FM
Leibrock
L G
LG
D000328:Adult; D001918:Brachytherapy / Q000379:methods*; D002817:Chordoma / Q000532:radiotherapy*; D003388:Cranial Fossa, Posterior; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012888:Skull Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D014057:Tomography, X-Ray Computed
D007457:Iodine Radioisotopes