Sound amplification negates central effects of a neonatal conductive hearing loss.
Neonatal CBA/J mice with external auditory meati removed were raised in a sound-amplified environment. If amplification continued until sacrifice at 24 or 45 days of age, both cochlear nuclear volumes and cross-sectional areas of VCN globular cells were of normal size; without amplification both measurements were significantly reduced.
Webster
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Kresge Hearing Research Laboratory of the South, Department of Otorhinoloaryngology, Louisiana State University Medical Center, New Orleans 70112.
D000161:Acoustic Stimulation; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D003056:Cochlear Nerve / Q000473:pathology; D034381:Hearing Loss / Q000209:etiology*; D006314:Hearing Loss, Conductive / Q000209:etiology* / Q000473:pathology; D051379:Mice; D008808:Mice, Inbred CBA