Single-dose kinetics of nifedipine in rat plasma and brain.
Nifedipine concentrations in plasma and brain tissue of rats were assayed from 5 min to 4 h after an intravenous injection of 6 mg/kg body weight. Samples of rat plasma and homogenized brain tissue were extracted under sodium light with a dichloromethane-pentane mixture. Analyses were done by high-performance liquid chromatography on a reverse-phase C18 column with electrochemical detection. The peak concentration of nifedipine in brain obtained after 10 min was 37 micrograms/g wet weight tissue, the half-life was 75 min. Apparently, nifedipine can easily cross the blood-brain barrier in the rat.
Janicki
P K
PK
Department of Pharmacology, Medical Academy of Warsaw, Poland.
Siembab
D
D
Paulo
E A
EA
Krzaścik
P
P
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D004304:Dosage Forms; D007700:Kinetics; D008297:Male; D009543:Nifedipine / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains
D004304:Dosage Forms; D009543:Nifedipine