title: Treatment of carcinoma of the skin with bone and/or cartilage involvement.
abstract: From 1956 to 1978, 23 patients with stage T4 carcinoma of the skin of the head and neck were treated with radiotherapy (RT). There were nine patients with cancer of the skin of the nose, eight with tumors of the pinna, and six with lesions of the eyelids. Basal cell carcinoma (BCC) was seen in 61%, squamous cell carcinoma (SCC) in 26%, and 13% of patients had tumors with BCC and SCC features. The majority of patients had large tumors. Less than one-third of patients had smaller lesions, whereas three patients had intermediate-size tumors (greater than 2 cm to less than or equal to 5 cm). Of the 23 patients treated, nine had prior surgical therapy and recurrent or persistent tumor. The remaining 14 patients had no prior therapy. RT was given up to an average total dose of 55 Gy. The 5-year actuarial tumor control rate was 80%. Of the 23 patients treated, four had recurrent tumors. There were no recurrences among the 14 BCC patients, whereas there were four recurrences among the nine SCC and mixed histology patients. Of the four patients who had tumor recurrence, one was salvaged by subsequent radical surgery and three died of their tumor. No serious complications were observed in this group of 23 patients. There was no cartilage, bone, or soft-tissue necrosis noted. RT is a good treatment option and it may be treatment of choice in patients with BCC and SCC of the skin with cartilage or bone involvement. It provides an excellent chance of tumor control, good cosmesis, preservation of function, and a low incidence of complications.
authors: Department of Radiation Oncology, University of Southern California School of Medicine, Los Angeles.
authors: Z
authors: Z
authors: Petrovich
authors: H
authors: H
authors: Kuisk
authors: B
authors: B
authors: Langholz
authors: G
authors: G
authors: Luxton
authors: M
authors: M
authors: Petrovich
authors: L
authors: L
authors: Chak
authors: D
authors: D
authors: Rice
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology*; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D002357:Cartilage Diseases / Q000473:pathology*; D005153:Facial Neoplasms / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy*