Hypotension as a manifestation of cardiotoxicity in three patients receiving cisplatin and 5-fluorouracil.
Cardiac symptoms, including hypotension, developed in three patients with advanced colorectal carcinoma while being treated with cisplatin (CDDP) and 5-fluorouracil (5-FU). In two patients, hypotension was associated with severe left ventricular dysfunction. All three patients required therapy discontinuation. Cardiac enzymes remained normal despite transient electrocardiographic (EKG) changes. The presentation and cardiac evaluation (hemodynamic, echocardiographic, and scintigraphic) of these patients suggest new manifestations of 5-FU cardiotoxicity that may be influenced by CDDP. The possible pathophysiologic mechanisms are discussed.
Jakubowski
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AA
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Kemeny
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N
D000328:Adult; D002945:Cisplatin / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000188:drug therapy; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000188:drug therapy
D002945:Cisplatin; D005472:Fluorouracil