Rubella antibody persistence after immunization. Sixteen-year follow-up in the Hawaiian Islands.
A comparative field trial of three rubella virus vaccines (Cendehill, HPV-77 DE-5, and HPV-77 DK-12) was initiated in 1969 on the islands of Kauai and Hawaii in the state of Hawaii. In 1985, follow-up was reinitiated to assess the long-term durability of vaccine-induced immunity. Enzyme-linked immunosorbent assays of serum specimens from 1290 participants demonstrated seropositive rates of 92.4% and 96.4% at screening levels of 10 (protective level) and 7 (lowest detectable level) IU/mL, respectively. The seropositive rates were not related to reinfection or reimmunizations. These findings indicate that vaccine-induced rubella antibodies are detectable in almost all persons up to 16 years after successful vaccination.
Chu
S Y
SY
Epidemiology Branch, Hawaii State Department of Health, Honolulu.
Bernier
R H
RH
Stewart
J A
JA
Herrmann
K L
KL
Greenspan
J R
JR
Henderson
A K
AK
Liang
A P
AP
D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D006254:Hawaii; D006801:Humans; D011897:Random Allocation; D012411:Rubella Vaccine / Q000276:immunology*; D012412:Rubella virus / Q000276:immunology*; D013997:Time Factors
D000914:Antibodies, Viral; D012411:Rubella Vaccine