Bile acids of patients with renal failure (possibility of bile acid secretion in the distal tubule).
Bile acids of patients with renal failure and of healthy subjects were analyzed by capillary gas chromatography after group separation. The amount of bile acids in the total dialysate (150 L) of the patients was smaller than that in the 24-h urine of healthy subjects. Polar bile acid sulfates constituted 17.3% and 30.9% of the total bile acids in serum and urine of healthy subjects, respectively, 26.0% in predialysis serum of patients, and only 11.3% in dialysate of patients. The amount of bile acid sulfates in the hemodialysate converted during a 24-h period dialysis, was still smaller than that in 24-h urine of healthy subjects. We propose that the distal tubule secretes bile acid sulfates.
Yamaga
N
N
Division of Biochemistry, Tottori University School of Medicine, Yonago, Japan.
Adachi
K
K
Kohara
H
H
Shimizu
K
K
D001647:Bile Acids and Salts / Q000097:blood* / Q000302:isolation & purification; D002849:Chromatography, Gas; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000503:physiopathology / Q000652:urine; D007684:Kidney Tubules / Q000503:physiopathology*; D007686:Kidney Tubules, Distal / Q000503:physiopathology*; D012016:Reference Values; D006435:Renal Dialysis
D001647:Bile Acids and Salts