Diffusion and uptake of dopamine in rat caudate and nucleus accumbens compared using fast cyclic voltammetry.
Fast cyclic voltammetry was used in the caudate and nucleus accumbens of anaesthetised rats to study the release and reuptake of dopamine following stimulation of the median forebrain bundle. Dopamine uptake was significantly slower in accumbens than caudate, indicating a lower number of functional uptake sites. This implies that dopamine may be able to diffuse further from its sites of release in nucleus accumbens than in caudate and thus may have a neuromodulator role in this region.
Stamford
J A
JA
Department of Pharmacology, London Hospital Medical College, U.K.
Kruk
Z L
ZL
Palij
P
P
Millar
J
J
D000818:Animals; D002421:Caudate Nucleus / Q000378:metabolism* / Q000502:physiology; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D004563:Electrochemistry; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism* / Q000502:physiology; D012686:Septal Nuclei / Q000378:metabolism*; D013997:Time Factors
D011954:Receptors, Dopamine; D004298:Dopamine