title: Extravesical subtrigonal injection of 50 per cent ethanol for detrusor instability.
abstract: Urinary incontinence with detrusor instability often is refractory to pharmacological therapy as well as other conservative modalities. We report the results obtained from 10 patients with detrusor incontinence who underwent extravesical subtrigonal injection of 50 per cent ethanol. Postoperatively, 9 of the 10 patients had conversion to detrusor stability and 6 had an acontractile bladder. Of the 10 patients 9 had an excellent result for at least 10 months postoperatively with 1 patient requiring 2 additional treatments to convert to detrusor stability. Complications included fistula formation in 3 patients, requiring primary closure in 2 and ileal diversion in 1. Of the 10 patients 7 remain dry or vastly improved at a mean of 24 months of followup.
authors: Department of Surgery, Stanford University Medical Center, California.
authors: R G
authors: RG
authors: Harris
authors: C E
authors: CE
authors: Constantinou
authors: T A
authors: TA
authors: Stamey
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D000431:Ethanol / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D001743:Urinary Bladder / Q000503:physiopathology*; D014550:Urinary Incontinence, Stress / Q000503:physiopathology / Q000628:therapy*; D014563:Urodynamics
chemical_list: D000431:Ethanol