Changes in respiratory control induced by amino acid infusions.
We compared the metabolic and respiratory responses to a 4-h infusion of an amino acid solution consisting primarily of branched-chain amino acids (BCAA) to those after a standard amino acid solution in healthy subjects. Both the BCAA solution and the standard amino acid solution increased minute ventilation (mean increase 22%, p less than .001, and 18%, p less than .01, respectively), mean inspiratory flow (19%, p less than .01, and 19%, p less than .05) and oxygen consumption (9%, p less than .02, and 5%, NS). PaCO2 decreased (mean decrease 6%, p less than .01); there was a major increase in the ventilatory response to CO2 inhalation during administration of the BCAA solution but not the standard amino acid solution. Increased plasma norepinephrine concentration (mean increase 75%, p less than .001) during the infusion of the standard amino acid solution but not the BCAA solution suggested increased sympathetic activity. The results demonstrate augmented respiratory effects of amino acid infusions by BCAA enrichment, and a dissociation between the respiratory stimulation, metabolic rate, and sympathetic activity.
Takala
J
J
Department of Surgery, College of Physicians & Surgeons of Columbia University, New York, NY.
Askanazi
J
J
Weissman
C
C
Lasala
P A
PA
Milic-Emili
J
J
Elwyn
D H
DH
Kinney
J M
JM
D000328:Adult; D000596:Amino Acids / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D004837:Epinephrine / Q000097:blood; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010101:Oxygen Consumption; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D012119:Respiration / Q000187:drug effects*
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D009638:Norepinephrine; D004837:Epinephrine