title: Chemical modification of steffimycin B.
abstract: Fifteen 3-substituted analogues of steffimycin B (1) have been synthesized and their activity against P388 murine leukemia has been determined. Three of these were substantially more active than the parent compound.
authors: Research Laboratories, Upjohn Company, Kalamazoo, Michigan 49001.
authors: P F
authors: PF
authors: Wiley
authors: D W
authors: DW
authors: Elrod
authors: D E
authors: DE
authors: Harper
mesh_terms: D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy; D009279:Naphthacenes / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; C009944:steffimycin