title: Complete prevention of acetylcholine induced coronary artery spasm with nifedipine.
abstract: A 63-year-old woman has been known to have angina pectoris due to coronary artery (CA) spasm. An intra-left CA infusion of acetylcholine (ACh) provoked spasms of the left CA and an anginal attack. After daily oral administration of nifedipine (NIF) for 2 weeks, intra-CA re-infusion study of ACh did not provoke any CA spasms. This is the first report to demonstrate the complete prevention of ACh-induced CA spasm with nifedipine.
authors: First Department of Internal Medicine, Fukui Medical School.
authors: K
authors: K
authors: Shimizu
authors: K B
authors: KB
authors: Ogawa
authors: T
authors: T
authors: Kato
authors: J D
authors: JD
authors: Lee
authors: A
authors: A
authors: Hara
authors: T
authors: T
authors: Nakamura
mesh_terms: D000109:Acetylcholine / Q000009:adverse effects*; D000787:Angina Pectoris / Q000209:etiology; D000792:Angiography; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*
chemical_list: D009543:Nifedipine; D000109:Acetylcholine