Amino-acid sequences of four cytotoxins (cytotoxins I, II, III and IV) purified from the venom of the Thailand cobra, Naja naja siamensis.
Four cytotoxins, designated as cytotoxins I, II, III and IV, were isolated from the venom of the Thailand cobra (Naja naja siamensis) by gel filtration on Sephadex G-75 followed by CM-cellulose chromatography. The amino-acid sequences were determined by a combination of conventional methods. Cytotoxins I, II, III and IV were each composed of 60 amino-acid residues and their molecular weights were calculated to be 6693, 6646, 6709 and 6739, respectively. The amino-acid sequences were compared with those of cytotoxins from other cobra venoms already sequenced.
Ohkura
K
K
Department of Biochemistry, Osaka University of Pharmaceutical Sciences, Japan.
Inoue
S
S
Ikeda
K
K
Hayashi
K
K
D000595:Amino Acid Sequence; D000818:Animals; D003603:Cytotoxins / Q000235:genetics* / Q000302:isolation & purification; D004546:Elapid Venoms / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D013045:Species Specificity
D003603:Cytotoxins; D004546:Elapid Venoms; C037375:cobra cytotoxin I; C045369:cobra cytotoxin II; C055953:cobra cytotoxin III; C055954:cobra cytotoxin IV