Identification of Bakb, a new platelet-specific antigen associated with posttransfusion purpura.
Baka is a platelet alloantigen whose putative allele, Bakb, has not been identified previously. By using a serum, "Har," obtained from a patient with posttransfusion purpura, we describe the platelet alloantigen Bakb. The Har serum reacted with an NP-40-extractable platelet membrane protein of 142 kd with mobility similar to platelet glycoprotein IIb alpha. We found that the antigen recognized by the Har serum is inherited in an autosomal dominant mode with an apparent gene frequency of .39. Chi-square analysis of observed and expected phenotype frequencies indicated that serum Har recognizes Bakb, the anticipated allele of Baka. Our findings provide new evidence for polymorphism of glycoprotein IIb and for the association of posttransfusion purpura with alloimmunization to determinants on this glycoprotein.
Kickler
T S
TS
Johns Hopkins University School of Medicine, Baltimore, MD.
Herman
J H
JH
Furihata
K
K
Kunicki
T J
TJ
Aster
R H
RH
D016824:Antigens, Human Platelet; D001792:Blood Platelets / Q000032:analysis / Q000145:classification / Q000276:immunology*; D004587:Electrophoresis, Agar Gel; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007118:Immunoassay; D007518:Isoantibodies; D007519:Isoantigens / Q000276:immunology / Q000302:isolation & purification*; D008875:Middle Aged; D010641:Phenotype; D011696:Purpura, Thrombocytopenic / Q000097:blood / Q000235:genetics / Q000276:immunology*
C044561:3a alloantigen, human; D016824:Antigens, Human Platelet; D007518:Isoantibodies; D007519:Isoantigens