Relaxin deficiency in the placenta as possible cause of cervical dystocia. A case report.
In a case of cervical dystocia which had to be delivered by caesarean section, the placenta was examined for relaxin content. The placenta was processed by acidic acetone extraction and separation of the raw extract on a carboxymethylcellulose column. The activity of relaxin was estimated by means of heterologous porcine radioimmunoassay. The elution profile of the placenta extract showed significant differences to that of the placenta in normal deliveries i.e. there was no evidence of typical protein peaks with relaxin activity. It is suggested that there is possibly a causal relationship between the lack of placental relaxin and the pathological behaviour of the cervix during delivery.
Entenmann
A H
AH
Department of Obstetrics and Gynecology, University of Tübingen, F.R.G.
Seeger
H
H
Voelter
W
W
Lippert
T H
TH
D000328:Adult; D004420:Dystocia / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D010920:Placenta / Q000032:analysis*; D011247:Pregnancy; D011863:Radioimmunoassay; D012065:Relaxin / Q000172:deficiency*; D002577:Uterine Cervical Diseases / Q000209:etiology* / Q000378:metabolism
D012065:Relaxin