Heparin-like tubings. I. Preparation, characterization and biological in vitro activity assessment.
In order to prepare tubular materials which could be used in blood-circulating medical devices, polystyrene was grafted by irradiation on to polyethylene tubings. A chemical surface treatment was used which resulted in the functionalization of the inner face of the tubing. This procedure is described and the chemical assessment of the constitution of the functionalized polymer has been completed. Tubing, the inner face of which is made of polyethylene-polystyrene copolymer in which polystyrene moieties were substituted with sulphonate and aspartic acid sulphamid groups, was tested for antithrombic properties in a circulating device under controlled transport conditions and by use of purified proteins.
Migonney
V
V
Laboratoire de Recherches sur les Macromolécules, Université Paris-Nord, Villetaneuse, France.
Fougnot
C
C
Jozefowicz
M
M
D000990:Antithrombin III / Q000494:pharmacology; D001224:Aspartic Acid; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D055598:Chemical Phenomena; D002621:Chemistry; D006493:Heparin; D008422:Materials Testing; D008752:Methylene Chloride; D011095:Polyethylenes; D012972:Sodium Hydroxide; D013451:Sulfonic Acids; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000378:metabolism
D001672:Biocompatible Materials; D011095:Polyethylenes; D013451:Sulfonic Acids; C013880:chlorosulfonic acid; D001224:Aspartic Acid; D012972:Sodium Hydroxide; D008752:Methylene Chloride; D000990:Antithrombin III; D006493:Heparin; D013917:Thrombin