Postischemic ATP levels predict hepatic function 24 hours following ischemia in the rat.
Hepatic function was assessed by the aminopyrine breath test (ABT) in male Sprague Dawley rats 24 h after partial hepatic ischemia. ABT decreased progressively to 26.3 (p less than 0.05) and 19.7% of dose (p less than 0.05) after 90 and 120 min of ischemia, respectively. ABT at 24 h after injury was correlated to the concentration of ATP in the ischemic lobes 1 h after the onset of reperfusion (r2 = 0.971) but not to ALT activity in plasma at 1 h (r2 = 0.391). We conclude that postischemic ATP levels are a better index of subsequent hepatic function than ALT.
Metzger
J
J
Department of Clinical Pharmacology, University of Bern, Switzerland.
Lauterburg
B H
BH
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000410:Alanine Transaminase / Q000378:metabolism; D000632:Aminopyrine; D000818:Animals; D001944:Breath Tests; D007511:Ischemia / Q000503:physiopathology*; D007700:Kinetics; D008099:Liver / Q000098:blood supply* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000632:Aminopyrine; D000255:Adenosine Triphosphate; D000410:Alanine Transaminase