[Cerebral ischemic accidents and chronic disseminated intravascular coagulation of cancerous origin].
Cerebral infarcts in 3 patients revealed the presence of disseminated intravascular coagulation (DIVC) of cancerous origin before any clinical manifestations of the neoplasm. Neurologic manifestations of these consumption coagulopathies almost constantly produce a picture of diffuse encephalopathy, expression of disseminated microinfarcts; however, transient or constituted focalized ischemic accidents by occlusion of a medium sized artery are also possible, and this in the absence of non-bacterial thrombotic endocarditis. Biologic diagnosis of DIVC is not always simple, and screening tests (platelet count, prothrombin and fibrinogen levels) can remain within normal limits during chronic forms, as a result of a subjacent inflammatory syndrome, frequently associated with cancer. Two other specific serum tests are therefore of fundamental interest: assay of fibrin degradation products and tests for soluble complexes.
Woimant
F
F
Unité d'Accidents Vasculaires Cérébraux, Hôpital Lariboisière, UER Lariboisière-Saint Louis, Paris.
Moulinier
L
L
Lecoz
P
P
Soria
C
C
Mikol
J
J
Cochan Priollet
B
B
Haguenau
M
M
Pépin
B
B
D000230:Adenocarcinoma / Q000150:complications; D000328:Adult; D002544:Cerebral Infarction / Q000209:etiology*; D003537:Cystadenoma / Q000150:complications; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D010051:Ovarian Neoplasms / Q000150:complications; D010190:Pancreatic Neoplasms / Q000150:complications; D010976:Platelet Count; D011516:Prothrombin / Q000032:analysis; D001749:Urinary Bladder Neoplasms / Q000150:complications
D005338:Fibrin Fibrinogen Degradation Products; D011516:Prothrombin; D005340:Fibrinogen
Accidents ischemiques cérébraux et coagulation intravasculaire disséminée chronique d'origine cancéreuse.