Interferon induces cell fusion and the formation of multinuclear cells in a culture of Ehrlich ascites tumor cells.
The increase in number of Ehrlich ascites tumor (EAT) cells was diminished significantly when the cell culture was treated with 1,000 IU/ml of recombinant mouse alpha or beta interferon (IFN). Microscopical observation revealed that almost all the cells showed bi- or multinuclear morphology 3 to 5 days after IFN treatment. Furthermore, a videorecording showed that each multinuclear cell arose by fusion after mitotic division of one parental cell.
Tominaga
S
S
Okinaka Memorial Institute for Medical Research, Tokyo, Japan.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D002459:Cell Fusion / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D007370:Interferon Type I / Q000502:physiology*; D007700:Kinetics; D051379:Mice; D011994:Recombinant Proteins / Q000494:pharmacology*
D007370:Interferon Type I; D011994:Recombinant Proteins