Apolipoprotein E in hepatocellular liver disease.
Apolipoprotein E concentrations in plasma were investigated in 17 patients with hepatocellular (non-cholestatic) liver disease. Ninety-five per cent of plasma apolipoprotein E was recovered in density fractions less than 1.063 kg/l and it was therefore associated with very low-density lipoproteins (VLDL) and low-density lipoproteins (LDL). Very low-density lipoproteins and LDL apolipoprotein E correlated positively (r = 0.63, p less than 0.01) with plasma bile salt concentrations when a decrease in liver protein synthesis was taken into account. This may be due to a down-regulation of the hepatic apolipoprotein B, E receptors concomitant with increasing plasma bile salt concentrations.
Florén
C H
CH
Department of Medicine, University Hospital, Lund, Sweden.
D000328:Adult; D000368:Aged; D001057:Apolipoproteins E / Q000097:blood*; D001647:Bile Acids and Salts / Q000097:blood; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood; D008107:Liver Diseases / Q000097:blood*; D008297:Male; D008875:Middle Aged
D001057:Apolipoproteins E; D001647:Bile Acids and Salts; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL