Prolonged deterioration of ischemic brain energy metabolism and acidosis associated with hyperglycemia: human cerebral infarction studied by serial 31P NMR spectroscopy.
We report on a patient with a large ischemic hemispherical stroke studied serially by 31P nuclear magnetic resonance spectroscopy. Persistent hyperglycemia was associated with prolonged acidosis in ischemic brain and failure of high-energy phosphate metabolism to recover. These in vivo human data support the concept that hyperglycemia adversely affects ischemic brain metabolism, pH, and clinical outcome.
Levine
S R
SR
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202.
Welch
K M
KM
Helpern
J A
JA
Chopp
M
M
Bruce
R
R
Selwa
J
J
Smith
M B
MB
D000138:Acidosis / Q000209:etiology*; D000368:Aged; D002545:Brain Ischemia / Q000378:metabolism*; D002544:Cerebral Infarction / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D006943:Hyperglycemia / Q000150:complications*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010710:Phosphates / Q000378:metabolism*
D010710:Phosphates