[Synthesis and pharmacological properties of des-9-glycine analogs of [Orn8]vasopressin].
Three new analogues of vasopressin, viz. des-Gly9-[Phe2, Orn8]vasopressin, diglycyl-des-Gly9-[Phe2, Orn8]vasopressin, and diglycyl-des-Gly9-[Val4, Orn8]vasopressin, were synthesized to investigate the structure-function relationship. Hormonal (vasopressor, antidiuretic, uterotonic, galactogogic) activities of the new compounds were determined, their effect on elaboration and retention of the active avoidance behaviour in rats was studied.
papsuevich
O S
OS
Barth
T
T
Chipens
G I
GI
Bakharev
V D
VD
Gaĭlite
E A
EA
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002942:Circular Dichroism; D003214:Conditioning, Classical / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D009951:Ornipressin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D014667:Vasopressins / Q000138:chemical synthesis* / Q000494:pharmacology
C056233:vasopressin, 9-des-Gly-(2-Phe-8-Orn)-; D014667:Vasopressins; C056234:vasopressin, 2-Gly-9-des-Gly-2-Phe-8-Orn-; C056241:vasopressin, 2-Gly-9-des-Gly-4-Val-8-Orn-; D009951:Ornipressin
Sintez i farmakologicheskie svoĭstva dez-9-glitsinovykh analogov [Orn8]vazopressina.