Hypertension-induced protein leakage in the brain in chronic ethanol administered rats.
The effect of adrenalin on permeability of blood brain barrier in chronic alcohol administered rats was examined by using Evans-blue as a barrier tracer. Chronic alcohol per se did not have remarkable effect on blood-brain barrier permeability. Adrenalin administration to the chronic alcohol group caused minimal disruption in blood brain barrier. The results shown that chronic alcohol protects the blood brain barrier permeability against hypertension due to adrenalin.
Oztaş
B
B
Department of Physiology Istanbul Faculty of Medicine University of Istanbul, Turkey.
Küçük
M
M
D000418:Albumins / Q000493:pharmacokinetics*; D000437:Alcoholism / Q000150:complications*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001812:Blood-Brain Barrier; D004837:Epinephrine / Q000494:pharmacology; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000209:etiology / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000418:Albumins; D004837:Epinephrine