Smoking topography and nicotine blood levels.
Frequency and durational components of smoking topography were measured by a portable smoking device while 10 subjects smoked four cigarettes ad libitum in a non-laboratory environment. Nicotine blood levels were measured before and after smoking each cigarette and serial blood samples for determining nicotine metabolic half-life were obtained the following day. Results showed that change in pre- and post-cigarette nicotine levels and metabolic half-life for nicotine were not related to within-cigarette topography measures or nicotine yield of cigarette, but were significantly related to intercigarette interval.
Hatsukami
D K
DK
Department of Psychiatry, University of Minnesota 55455.
Pickens
R W
RW
Svikis
D S
DS
Hughes
J R
JR
D000328:Adult; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D009538:Nicotine / Q000493:pharmacokinetics*; D012907:Smoking / Q000097:blood* / Q000523:psychology
D009538:Nicotine