[D-penicillamine in the treatment of recurrent laryngeal stenosis in children].
Five children with recurrent tracheal stenosis after use of an endolaryngeal calibrator and/or a laryngoplasty were treated with D-penicillamine and chloroquine. The relevant literature relating to biological processes of normal and pathologic healing is reviewed, particularly with respect to the effect of D-penicillamine on collagen synthesis. Decannulation was possible in 4 of the children reported presently, including three in whom medical treatment was combined with use of an endolaryngeal calibrator.
De Waele
C
C
Service ORL Hôpital Necker Enfants-Malades, Paris.
Manach
Y
Y
Florant
A
A
Perrin
A
A
D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use*; D003094:Collagen / Q000096:biosynthesis / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects; D007829:Laryngostenosis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use*; D012008:Recurrence; D014945:Wound Healing
D002738:Chloroquine; D003094:Collagen; D010396:Penicillamine
La D. penicillamine dans le traitement des stenoses laryngées récidivantes de l'enfant.