SF2446, new benzo[a]naphthacene quinone antibiotics. I. Taxonomy and fermentation of the producing strain, isolation and characterization of antibiotics.
New antibiotics SF2446A1, A2, A3, B1 and B2 have been isolated from the culture of Streptomyces sp. SF2446 and antibiotic SF2446B3 has been obtained by methanolysis of SF2446B1 or B2. SF2446A1, A2 and B1 showed strong inhibitory activities against mycoplasmas and Gram-positive bacteria. Empirical molecular formulae of antibiotics SF2446-A1, A2, A3, B1, B2 and B3 were determined to be C34H35NO15, C26H21NO11, C34H35NO14, C34H35NO14 and C26H21NO10, respectively.
Takeda
U
U
Pharmaceutical Research Laboratories, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
Okada
T
T
Takagi
M
M
Gomi
S
S
Itoh
J
J
Sezaki
M
M
Ito
M
M
Miyadoh
S
S
Shomura
T
T
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D051379:Mice; D009279:Naphthacenes; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D009279:Naphthacenes; C056021:SF 2446A1; C056023:SF 2446A3; C056024:SF 2446B1; C056022:SF 2446A2; C056025:SF 2446B2