title: Nucleolar changes induced by isoproterenol in mouse acinar parotid cells.
abstract: This paper deals with the analysis of the nucleolar morphology and distribution of the nucleolar component (i.e. fibrils and granules) in normal and isoproterenol-treated parotid acinar cells of mice. Normally nucleoli present both components intermingled, but at 2 h treatment a considerable decrease of the fibrillar area is detected by a silver staining method. Normal nucleolar characteristics are recovered after eight hours treatment. In hypertrophic cells nucleolar size is considerably increased, but the ratio total nucleolar area/fibrillar area is similar to control cells as shown by a stereometrical computerized analysis. Rounded nucleolar bodies occur in these nuclei which do not seem to be dependent on the modifications induced by the drug.
authors: Departamento de Biología y Genética, Facultad de Medicina, Universidad de Chile, Santiago.
authors: C
authors: C
authors: Alliende
authors: P
authors: P
authors: Esponda
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D006651:Histocytochemistry; D007545:Isoproterenol / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D010306:Parotid Gland / Q000032:analysis / Q000166:cytology / Q000187:drug effects*
chemical_list: D007545:Isoproterenol