title: An abnormal expression of a tumor-activated multigenic set in cells from cancer prone patients with inherited Fanconi's anemia (FA) and retinoblastoma (Rb).
abstract: Normal skin fibroblasts from patients genetically predisposed for cancer express certain phenotypic properties usually associated with transformed cells, suggesting that these cells are engaged in a cancer progression process. Previously, we have shown that a subgenomic fraction, which we called Ta DNA ('tumor-activated DNA') was preferentially expressed in all human tumor cells (Hanania et al., Proc. Natl. Acad. Sci. U.S.A., 78 (1981) 6504-6508; Hanania et al, EMBO J., 2 (1983) 1621-1624). Here, we show that Ta DNA transcripts are present in Fanconi's anemia (FA) and retinoblastoma (Rb) fibroblasts, at a level hardly lower than in tumor cells. In contrast, a few Ta DNA transcripts can be detected in normal cells.
authors: CNRS UA 1158, Oncologie Moléculaire, Villejuif, France.
authors: N
authors: N
authors: Hanania
authors: C
authors: C
authors: Diatloff-Zito
authors: D
authors: D
authors: Schaool
mesh_terms: D000741:Anemia, Aplastic / Q000235:genetics*; D004273:DNA, Neoplasm / Q000032:analysis*; D005134:Eye Neoplasms / Q000235:genetics*; D005199:Fanconi Anemia / Q000235:genetics*; D006801:Humans; D009693:Nucleic Acid Hybridization; D012175:Retinoblastoma / Q000235:genetics*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014158:Transcription, Genetic
chemical_list: D004273:DNA, Neoplasm; D013755:Tetradecanoylphorbol Acetate