title: Placental and milk transfer of chloroquine in humans.
abstract: The placental and milk transfer of chloroquine was studied in seven subjects and six subjects, respectively. Seven pregnant women at term were administered chloroquine phosphate (5 mg/kg) i.m. The maternal blood and arterial and venous umbilical cord blood were obtained during delivery. The maternal chloroquine blood levels varied from 0.438 to 1.193 micrograms/ml. The venous cord blood ranged from 0.607 to 0.869, whereas the arterial levels ranged from 0.480 to 0.905 micrograms/ml. Six subjects who were administered chloroquine phosphate (5 mg/kg) postpartum had chloroquine milk levels of 0.192-0.319 micrograms/ml. The milk:blood ratio ranged from 0.268 to 0.462. Chloroquine readily crossed the placenta and was excreted into the breast milk.
authors: Department of Pharmacology, College of Medicine, University of Lagos, Nigeria.
authors: A
authors: A
authors: Akintonwa
authors: S A
authors: SA
authors: Gbajumo
authors: A F
authors: AF
authors: Mabadeje
mesh_terms: D000293:Adolescent; D000328:Adult; D002738:Chloroquine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D007273:Injections, Intramuscular; D008895:Milk, Human / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D002738:Chloroquine