Metronidazole versus placebo in the treatment of gaseous discomfort in patients having an ileostomy. A double-blind cross-over investigation.
In a double-blind, cross-over trial with metronidazole (Flagyl) 400 mg twice daily and placebo given to suitably adjusted ileostomy operated patients during two week periods, no significant reduction could be demonstrated in gaseous discomfort as measured by the number of bag emptyings per day, as well as gaseous symptoms in the form of the passage of flatulence from the stoma and borborygmi.
Funder
V
V
Department of Surgical Gastroenterology, Bispebjerg Hospital, Copenhagen, Denmark.
Ottsen
B
B
Kjaergaard
J
J
D000328:Adult; D003082:Colectomy; D004311:Double-Blind Method; D005260:Female; D005414:Flatulence / Q000188:drug therapy*; D006801:Humans; D007081:Ileostomy; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy; D011897:Random Allocation
D008795:Metronidazole