[Immunomodulating therapy of adjuvant disease in rats].
During a comparative analysis of efficacy of prodigiosan and its combinations with cyclophosphamide (5 mg/kg), asathioprine (4 and 20 mg/kg) and delagil (25 mg/kg) it was shown that the most pronounced suppression of the adjuvant disease was observed in the group of animals given cyclophosphamide with prodigiosan. The suppression of arthritis with cyclophosphamide, prodigiosan and their combination was followed by a decrease of autosensibility parameters--hypersensitivity to collagen and the amount of immune rosette-forming cells in the regional lymph nodes.
Sibiriak
S V
SV
Lazareva
D N
DN
Khaĭbullina
S F
SF
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology; D001379:Azathioprine / Q000627:therapeutic use; D002738:Chloroquine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D011354:Prodigiozan / Q000627:therapeutic use; D051381:Rats; D014498:Uracil / Q000031:analogs & derivatives / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D014498:Uracil; C008378:6-methyluracil; C023676:chloroquine diphosphate; D002738:Chloroquine; D003520:Cyclophosphamide; D011354:Prodigiozan; D001379:Azathioprine
Nekotorye aspekty immunomoduliruiushcheĭ terapii ad''iuvantnoĭ bolezni krys.