Neural control of renal function in edema-forming states.
To define the role of the renal nerves in renal sodium-retaining edema-forming states, experiments were conducted in conscious chronically instrumented rats with congestive heart failure (myocardial infarction), nephrotic syndrome (adriamycin injection), and hepatic cirrhosis (common bile duct ligation). In each experimental model, renal excretion, as water or sodium, of an acutely administered oral or intravenous isotonic saline load was significantly less than that in control rats. Bilateral renal denervation of the experimental rats restored their renal excretory response to that of the control rats. In addition, in response to the acute administration of a standard intravenous isotonic saline load, the decrease in efferent renal sympathetic nerve activity was significantly less in all three experimental models compared with that of control rats. These results suggest that the impaired ability to excrete an acute isotonic saline load in these experimental models is partially dependent on an increase in basal efferent renal sympathetic nerve activity that fails to suppress normally in response to the isotonic saline load.
DiBona
G F
GF
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City.
Herman
P J
PJ
Sawin
L L
LL
D000818:Animals; D003714:Denervation; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000494:pharmacology; D004487:Edema / Q000503:physiopathology*; D004525:Efferent Pathways / Q000187:drug effects / Q000503:physiopathology; D006333:Heart Failure / Q000503:physiopathology*; D007668:Kidney / Q000294:innervation* / Q000502:physiology / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000503:physiopathology*; D008297:Male; D009404:Nephrotic Syndrome / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*
D004317:Doxorubicin