title: Oxidative metabolites of 5-nitrofurans.
abstract: We synthesized the 4-hydroxy derivatives of nitrofurazone, furazolidone and nitrofurantoin. Then we dosed rats orally with these antibiotics and isolated the intensely yellow, polar metabolites from their urine. A comparison of the ultraviolet and nuclear magnetic resonance spectra of these metabolites with the corresponding synthetic derivatives confirmed that the metabolites are 4-hydroxynitrofurazone, 4-hydroxyfurazolidone and 4-hydroxynitrofurantoin.
authors: Department of Pharmacy, School of Pharmacy, University of California, San Francisco.
authors: A J
authors: AJ
authors: Streeter
authors: T R
authors: TR
authors: Krueger
authors: B A
authors: BA
authors: Hoener
mesh_terms: D000818:Animals; D005664:Furazolidone / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D009682:Magnetic Resonance Spectroscopy; D009582:Nitrofurantoin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D009583:Nitrofurazone / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D010084:Oxidation-Reduction; D051381:Rats
chemical_list: C056133:4-hydroxynitrofurazone; C056136:4-hydroxyfurazolidone; D005664:Furazolidone; C056135:4-hydroxynitrofurantoin; D009582:Nitrofurantoin; D009583:Nitrofurazone