title: [Pharmacokinetics of anthracycline antibiotics deposited by polymers].
abstract: An increase of doxorubicin concentration in different organs and tissues and its decrease in the peripheral blood were observed when studying pharmacokinetics of this drug administered in the 10% solution of polyvinylpyrrolidone. A prolonged and stable release of carminomycin from glue composition MK-10-0 "carminacryl" confirms an expediency of alpha-cyanoacrylate use for deposition of anthracycline antibiotics with the aim of loco-regional chemotherapy.
authors: I G
authors: IG
authors: Rusakov
authors: A D
authors: AD
authors: Li
authors: A Ia
authors: AIa
authors: Akimova
authors: K G
authors: KG
authors: Shchitkov
mesh_terms: D000818:Animals; D002360:Carubicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003487:Cyanoacrylates / Q000008:administration & dosage*; D003630:Daunorubicin / Q000031:analogs & derivatives*; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004353:Drug Evaluation, Preclinical; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D014677:Pharmaceutical Vehicles; D011205:Povidone / Q000008:administration & dosage*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003487:Cyanoacrylates; D014677:Pharmaceutical Vehicles; D004317:Doxorubicin; D002360:Carubicin; D011205:Povidone; D003630:Daunorubicin
vernacular_title: Izuchenie farmakokinetiki antratsiklinovykh antibiotikov deponirovannykh polimerami.