Responsiveness of genetically epilepsy-prone rats to intracerebroventricular morphine-induced convulsions.
The sensitivity to intracerebroventricular morphine-induced convulsions was determined in members of the severe seizure (GEPR-9) and moderate seizure (GEPR-3) colonies of genetically epilepsy-prone rats as well as in non-epileptic control rats. GEPR-9s were more sensitive to morphine-induced wet-dog shakes, rearing with bilateral forelimb clonus and generalized clonus than controls of GEPR-3s. GEPR-3s were less sensitive to morphine-induced wet-dog shakes and rearing with bilateral forelimb clonus than controls. Both high and extremely low doses of morphine in GEPR-9s elicited tonic extensor convulsions resembling the characteristic sound-induced convulsion of GEPR-9s. The results suggest that opiotergic systems may contribute to the pathophysiology of the seizure-prone condition in GEPR-9s. Further, differences in responsiveness of opiotergic systems in GEPR-3s and GEPR-9s may partially account for differences in seizure severity in the characteristic sound-induced seizures of these two types of GEPRs.
Reigel
C E
CE
Department of Basic Sciences, University of Illinois College of Medicine, Peoria 61656.
Jobe
P C
PC
Dailey
J W
JW
Stewart
J J
JJ
D000818:Animals; D004827:Epilepsy / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000139:chemically induced*
D009270:Naloxone; D009020:Morphine