[Preoperative treatment of lymph node metastases of gastric cancer by local injection of 5-FU adsorbed on activated carbon--clinical study of 5-FU concentration in resected lymph nodes].
The concentration of 5-fluorouracil (5-FU) in blood and lymph node of 55 patients with gastric cancer who were endoscopically injected 250 mg of 5-FU alone or adsorbed on activated carbon into the gastric wall or 300 mg of 5-FU dry syrup orally before operation, were measured chronologically. The concentration of 5-FU in blood were similar in all cases but higher in lymph node in the group given adsorbed preparation than other cases. In the cases given adsorbed preparation, the lymph node concentration was remained high 7 days after injection, and in 37% cases more than the minimum inhibitory concentration of 5-FU remained. Therefore, for the purpose to elicit anticancer effect on micrometastasis in lymph nodes in the patients with gastric cancer, endoscopically preoperative injection of 5-FU adsorbed on activated carbon seemed to be useful.
Kobayashi
O
O
Dept. of Surgery, Kanagawa Cancer Center Hospital.
Motohashi
H
H
Sairenji
M
M
Fujimoto
Y
Y
Sugimasa
Y
Y
Takemiya
S
S
Okamoto
T
T
Tamai
S
S
Iimori
K
K
Murakami
K
K
D000327:Adsorption; D002244:Carbon / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D007267:Injections; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000378:metabolism*; D008207:Lymphatic Metastasis; D011300:Preoperative Care; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
D002244:Carbon; D005472:Fluorouracil