Thyroid function during co-administration of lithium and carbamazepine compared to lithium alone.
Among 20 chronically psychotic patients, half of whom received lithium and half of whom received the combination of lithium and carbamazepine, thyroxine levels were slightly higher and thyroid stimulating hormone levels were slightly lower among the patients receiving lithium compared with the patients receiving the combination of lithium and carbamazepine. The clinical implications of our findings are discussed.
Vieweg
W V
WV
Western State Hospital, Department of Mental Health and Mental Retardation, Staunton, VA 24401.
Godleski
L S
LS
Yank
G R
GR
Rowe
W T
WT
Hovermale
L S
LS
D000328:Adult; D002220:Carbamazepine / Q000008:administration & dosage / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011618:Psychotic Disorders / Q000188:drug therapy*; D013961:Thyroid Gland / Q000187:drug effects*; D013972:Thyrotropin / Q000032:analysis; D013974:Thyroxine / Q000032:analysis
D002220:Carbamazepine; D013972:Thyrotropin; D008094:Lithium; D013974:Thyroxine