[pHmetry and manometry of the esophagus in patients with pain of the angina type and a normal angiography].
The role of gastroesophageal reflux and esophageal motility abnormalities in patients with angina-type chest pain and normal coronary angiogram is not clear. The aim of this study was: a) to assess the importance of these two disorders in the same patients, b) to study the diagnostic usefulness of provocation tests, c) to determine final outcome in these patients. Seventeen patients with angina-type chest pain and normal coronary angiograms were studied to determine the diagnostic value of esophageal manometry, postprandial esophageal pH monitoring, provocation tests (methylergometrine stimulation, acid perfusion test) and endoscopy. Baseline esophageal motility was abnormal in 10 patients. Esophageal motility disorders were nonspecific in seven patients. Eight patients had reflux. The mean lower esophageal sphincter pressure was decreased in these patients as compared with normals, and endoscopy showed a high Z line, and/or a large opening of the cardia in 7 of them. Neither conventional manometry nor postprandial esophageal pH monitoring allowed to consider the esophagus as responsible for chest pain. The methylergometrine test was positive in 4 patients (simultaneous occurrence of familiar pain and esophageal dysmotility). Baseline manometric studies did not allow to forecast the response to methylergometrine injection. The acid perfusion test was negative (no symptoms were reproduced) in all patients. After esophageal evaluation, 16 patients were followed for a mean of 26 +/- 9 months. No cardiac disorders appeared, but all patients continued to have pain, and 7 were incapable of working.(ABSTRACT TRUNCATED AT 250 WORDS)
Thévenet
P
P
Laboratoire de Physiologie et d'Explorations Fonctionnelles, CHU Pontchaillou, Rennes.
Gosselin
A
A
Bourdonnec
C
C
Gosselin
M
M
Bretagne
J F
JF
Gastard
J
J
Lebars
R
R
D000328:Adult; D000787:Angina Pectoris; D002637:Chest Pain / Q000209:etiology*; D017023:Coronary Angiography; D004935:Esophageal Diseases / Q000150:complications* / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000150:complications; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010528:Peristalsis; D011379:Prognosis; D011446:Prospective Studies
pH-métrie et manométrie de l'oesophage chez des sujets avec douleurs de type angineux et une coronarographie normale.