Consistent breakpoints in region 14q22-q24 in uterine leiomyoma.
The chromosomes of nine consecutive human benign leiomyomas of the uterus were studied with banding methods following short-term culture. All of the tumors had a typical benign histology. Five exhibited clonal chromosome changes including three with consistent involvement of chromosomes 12 and 14 in a translocation, t(12;14)(q14-15;q23-q24), a direct insertion, dir ins(12;14)(p11.2;q22q24.1), and a direct insertion, dir ins(14;12)(q22-q23;q14-q15q23-q24.1). Thus, this study demonstrated the presence of consistent chromosome changes in another benign proliferation. Strikingly, the breakpoint observed at 12q14-q15 in two specimens is also involved nonrandomly in other benign proliferations such as mixed salivary gland tumors and lipomas. However, region 14q22-q24, which was involved in three specimens, may contain a DNA sequence critical for the genesis of uterine leiomyoma.
Turc-Carel
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Cancer Center, Southwest Biomedical Research Institute, Scottsdale, AZ 85251.
Dal Cin
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P
Boghosian
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Terk-Zakarian
J
J
Sandberg
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AA
D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002881:Chromosomes, Human, Pair 12; D002883:Chromosomes, Human, Pair 14; D005260:Female; D006801:Humans; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics*; D014178:Translocation, Genetic; D014594:Uterine Neoplasms / Q000235:genetics*