Inhibition of glyoxalase I by various clinically used anticancer drugs.
The antiglyoxalase activity of eight well-known anticancer drugs has been evaluated, their I50 values were determinated and compared to those of standard inhibitors S-octylglutathione and squaric acid. Among them methotrexate was found to be as potent as S-octylglutathione.
Kraus
J L
JL
Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Marseille, France.
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D000970:Antineoplastic Agents / Q000494:pharmacology*; D007791:Lactoylglutathione Lyase / Q000037:antagonists & inhibitors*; D008190:Lyases / Q000037:antagonists & inhibitors*; D008727:Methotrexate / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D008190:Lyases; D007791:Lactoylglutathione Lyase; D008727:Methotrexate