In vitro metabolism of trenbolone: study of the formation of covalently bound residues.
In order to study the formation of bound residues of trenbolone, in vitro experiments were performed using bovine liver microsomes. These experiments showed that hepatic mono-oxygenases can generate reactive metabolites, which are able to bind to microsomal proteins or can be detoxified by conjugation to glutathione or to glutathione-S-transferases. Bioavailability and toxicological properties of these adducts are discussed.
Evrard
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P
Université de Liège, Faculté de médecine vétérinaire, Analyse des denrées alimentaires d'origine animale, Brussels, Belgium.
Maghuin-Rogister
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G
D000818:Animals; D002417:Cattle; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000378:metabolism*; D004963:Estrenes / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D014204:Trenbolone Acetate / Q000378:metabolism*
D004963:Estrenes; D005982:Glutathione Transferase; D005978:Glutathione; D014204:Trenbolone Acetate