The effect of L-dopa on in vivo dopamine release from nigrostriatal bundle neurons.
We have examined the impact of L-dihydroxyphenylalanine (L-DOPA) on the in vivo release of dopamine (DA) in rat striatum using carbon fiber voltammetry. L-DOPA caused a large increase in the DA released by nigrostriatal bundle stimulation. This was reduced by 94% in animals pretreated with intraventricular 6-hydroxydopamine. We conclude that L-DOPA increases depolarization-induced DA release from DA neurons.
Keller
R W
RW
Department of Behavioral Neuroscience, University of Pittsburgh, PA 15260.
Kuhr
W G
WG
Wightman
R M
RM
Zigmond
M J
MJ
D000818:Animals; D002230:Carbidopa / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D007700:Kinetics; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D012016:Reference Values; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*
D007980:Levodopa; D002230:Carbidopa; D004298:Dopamine