Peptides and the senescent blood-brain barrier.
Peptides can influence numerous systems known to be altered by aging. They can affect the passage of non-peptide substances across the blood-brain barrier (BBB) and themselves can cross by both saturable and non-saturable transport mechanisms. The passage of peptides across the BBB is influenced by numerous physiological and pathological events, including aging. Taken together, the evidence suggests that alterations in peptide/BBB interactions may play a significant role in senescence.
Banks
W A
WA
Section of Medicine, Veterans Administration Medical Center, New Orleans, LA.
Kastin
A J
AJ
D000368:Aged; D000375:Aging / Q000502:physiology*; D000818:Animals; D001692:Biological Transport; D001696:Biomechanical Phenomena; D001812:Blood-Brain Barrier; D002352:Carrier Proteins / Q000378:metabolism; D002560:Cerebrovascular Circulation; D004058:Diffusion; D004745:Enkephalins / Q000378:metabolism; D006801:Humans; D010455:Peptides / Q000378:metabolism / Q000502:physiology*; D014118:Toxins, Biological / Q000494:pharmacology
D002352:Carrier Proteins; D004745:Enkephalins; D010455:Peptides; D014118:Toxins, Biological