title: Synergistic effects of Fusobacterium necrophorum lipopolysaccharide, cytoplasmic, and culture supernatant fractions on induction of acute hepatic necrosis in rabbits.
abstract: Synergistic effects of toxic fractions of Fusobacterium necrophorum were examined for evaluation of the role of the toxin in inducing liver abscesses in rabbits. Cytoplasmic and culture supernatant fractions of F necrophorum had preparative activity for the Shwartzman reaction, and lipopolysaccharide of F necrophorum had preparative and provocative activities for the reaction. All 3 fractions were hepatotoxic. Inoculation into the bile duct with each fraction followed by intravenous inoculation with F necrophorum or Escherichia coli lipopolysaccharide had a greater synergistic effect in inducing severe hepatic necrosis than did inoculations with double doses of the cytoplasmic or supernatant fractions of F necrophorum. This synergism may have been attributable to the Shwartzman reaction.
authors: Tohoku Branch, National Institute of Animal Health, Aomori, Japan.
authors: Y
authors: Y
authors: Nakajima
authors: H
authors: H
authors: Ueda
authors: S
authors: S
authors: Takeuchi
mesh_terms: D000208:Acute Disease; D000818:Animals; D001427:Bacterial Toxins / Q000009:adverse effects*; D003593:Cytoplasm; D004357:Drug Synergism; D004731:Endotoxins / Q000009:adverse effects*; D005260:Female; D005675:Fusobacterium necrophorum; D008070:Lipopolysaccharides / Q000633:toxicity; D008107:Liver Diseases / Q000209:etiology* / Q000382:microbiology; D008297:Male; D009336:Necrosis; D011817:Rabbits
chemical_list: D001427:Bacterial Toxins; D004731:Endotoxins; D008070:Lipopolysaccharides