title: Influence of maternal obesity on fetal development in pigs.
abstract: Fetuses from linebred lean (L) and linebred obese (O) and reciprocal crossmatings were examined at 110 d of gestation for line, maternal and heterotic effects. There was no significant heterotic effect for any trait measured. A significant maternal effect was observed for adipose tissue lipoprotein lipase (LPL) activity and for serum triglycerides. The enzyme activity and triglycerides concentration were higher in fetuses from O dams than in fetuses from L dams. In a lipid clearance test, no maternal effect was observed for changes in serum concentrations of triglycerides and free fatty acids or in optical density (associated with the disappearance of injected Liposyn). Linebred O fetuses exhibited higher LPL activity in both the biceps femoris muscle and sc adipose tissue compared with linebred L fetuses. The LPL activity of the adipose tissue was higher than that of the skeletal muscle. The percentage of dry matter, percentage of triglycerides and protein/DNA were higher in the muscle of linebred O fetuses than in that of linebred L fetuses. Based on tissue LPL activity and on muscle compositional traits, linebred O fetuses were more mature at 110 d of gestation than were the linebred L fetuses. Maternal obesity had little detectable influence on fetal development of the pig when measured at 110 d of gestation.
authors: Richard B. Russell Agriculture Research Center, U.S. Department of Agriculture, Athens, GA 30613.
authors: D R
authors: DR
authors: Campion
authors: G J
authors: GJ
authors: Hausman
authors: R T
authors: RT
authors: Stone
authors: J
authors: J
authors: Klindt
mesh_terms: D000818:Animals; D005314:Embryonic and Fetal Development; D005260:Female; D009765:Obesity / Q000503:physiopathology / Q000662:veterinary*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D013552:Swine / Q000502:physiology*