title: Synthesis of cyclic oligonucleotides by a modified phosphotriester approach.
abstract: Evidence will be presented to show that the allyl group is suitable for the protection of a 3'-terminal phosphodiester function. The latter will be demonstrated by the synthesis, via a phosphotriester approach, of two cyclic tetraribonucleotides [r(AAAA) and r(UAMe2UAMe2)], two cyclic hexadeoxyribonucleotides [d(CGCGCG) and d(TAAAAA)] and a cyclic octadeoxyribonucleotide [d(CGTGCGTG)].
authors: Gorlaeus Laboratory, Leiden, The Netherlands.
authors: E
authors: E
authors: de Vroom
authors: H J
authors: HJ
authors: Broxterman
authors: L A
authors: LA
authors: Sliedregt
authors: G A
authors: GA
authors: van der Marel
authors: J H
authors: JH
authors: van Boom
mesh_terms: D004355:Drug Stability; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009712:Nucleotides, Cyclic / Q000138:chemical synthesis*; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D010710:Phosphates
chemical_list: D007202:Indicators and Reagents; D009712:Nucleotides, Cyclic; D009838:Oligodeoxyribonucleotides; D009843:Oligoribonucleotides; D010710:Phosphates