Clomiphene blocks the effect of intravenous estradiol on the firing rate of rat nigral dopamine neurons.
Intravenous 17-beta-estradiol (BETA) has a potent, stereo-specific, and rapid effect on dopamine (DA) neuron firing rate in the substantia nigra compacta (SNC). Our data demonstrate that immediate intravenous pretreatment with the anti-estrogen clomiphene (CLOM) blocks the action of subsequent intravenous BETA administration. Our results provide further physiologic evidence for membrane-bound estradiol (E2) receptors within the rat brain.
McCall
W V
WV
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710.
Ellinwood
E H
EH
Nishita
J K
JK
Lee
T H
TH
D000818:Animals; D002996:Clomiphene / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology*; D004594:Electrophysiology; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D007275:Injections, Intravenous; D009474:Neurons / Q000187:drug effects*; D010052:Ovariectomy; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000166:cytology / Q000187:drug effects*
D004965:Estrogen Antagonists; D002996:Clomiphene; D004298:Dopamine