Experimental rat model for human yolk sac tumor.
The morphological and biological characteristics of experimentally induced rat yolk sac carcinomas (ysca) are compared to those of human yolk sac tumors. It is shown that the rat ysca shares many morphological and biological properties with its human counterpart although the cellular origin is probably different. Whereas the human yolk sac tumors are believed to be of germ cell origin, the rat visceral yolk sac-derived tumors are not. The hypothesis is formulated that the rat ysca are derived from multipotential cells different from germ cells, and which originate in the extra-embryonic membrane after displacement.
Vandeputte
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Rega Institute, University of Leuven, Belgium.
Sobis
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D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000648:ultrastructure; D002472:Cell Transformation, Viral; D004195:Disease Models, Animal; D006801:Humans; D008649:Mesonephroma / Q000209:etiology* / Q000648:ultrastructure; D008980:Moloney murine sarcoma virus; D011533:Proviruses; D051381:Rats