title: Identification and changes in the pattern of expression of slow-skeletal-muscle-like myosin heavy chains in a developing fast muscle.
abstract: Immunochemical studies of chicken pectoralis major, a fast muscle, have demonstrated large amounts of myosin heavy chains (MHCs) of the slow-skeletal-muscle type during early stages of embryonic development. A large majority of the myotubes present in early embryonic muscle stained for this class of MHC. As development progressed, its synthesis was suppressed in most of the muscle, except in the deeper presumptive red-strip region. The level of this MHC in the embryonic muscle appeared to be reduced by its suppression in a proportion of the existing cells, by the addition of many presumptive fast cells that never expressed this MHC, and by atrophy or degeneration of a small proportion of the slow MHC-positive cells. Further suppression of this MHC in a proportion of the histochemically typed slow cells present in the red-strip region did not occur until quite late in the post-hatch period.
authors: Department of Immunology, Medical School, University of Birmingham, United Kingdom.
authors: G K
authors: GK
authors: Dhoot
mesh_terms: D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D005786:Gene Expression Regulation; D007150:Immunohistochemistry; D009132:Muscles / Q000196:embryology* / Q000378:metabolism; D009218:Myosins / Q000235:genetics* / Q000378:metabolism
chemical_list: D009218:Myosins