CNS toxicity associated with intraventricular injection of cefazolin. Report of three cases.
Three patients who experienced central nervous system toxicity secondary to intraventricular therapy with cefazolin are described. On the basis of this experience it is recommended that cefazolin not be used for intraventricular antibiotic therapy in the treatment of shunt infections.
Manzella
J P
JP
Department of Medicine, York Hospital, Pennsylvania.
Paul
R L
RL
Butler
I L
IL
D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology; D002437:Cefazolin / Q000009:adverse effects*; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects; D002675:Child, Preschool; D005260:Female; D006261:Headache / Q000139:chemically induced; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D008875:Middle Aged; D013617:Tachycardia, Supraventricular / Q000139:chemically induced
D002437:Cefazolin