[31-P-spectroscopy as a method for studying biochemical changes in skin tumors: exemplified by malignant melanoma and squamous cell carcinoma].
We report on the basic principles concerning in vivo P-31 MR spectroscopy and give a short review of the corresponding studies on skin tumors described in the literature. Malignant melanoma and squamous cell carcinoma are both characterized by high concentrations of phosphomonoester and phosphodiester. By means of the P-31 spectroscopy technique, we are able to detect changes regarding the tumor metabolism as a response to chemotherapy, irradiation, or biological immune modifiers (e.g. interferon).
Kiricuta
I C
IC
Klinik für Radiologie des Kath, Marienhospitals Herne, Ruhr-Universität Bochum.
Schmitt
W G
WG
Beyer
H K
HK
D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008545:Melanoma / Q000473:pathology*; D010710:Phosphates / Q000378:metabolism*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
D010710:Phosphates
Die 31-P-Spektroskopie als Methode der Untersuchung biochemischer Veränderungen in Hauttumoren: am Beispiel des malignen Melanoms und des Plattenepithelcarcinoms.