Ventricular fibrillation-defibrillation in the toad Bufo paracnemis.
Fibrillation is more likely to occur in animals showing a high degree of cellular differentiation. Lower species, with cardiac tissue histologically and electrophysiologically more uniform, very rarely, if ever, can fall into this uncoordinated activity. We describe experiments during which two specimens of the South American toad, Bufo paracnemis (body weights, 363 g and 297 g; ventricular weights, 1.8 g and 1.4 g, respectively), were repeatedly fibrillated and defibrillated almost at will. However, we failed when we tried a series of experiments in a given number of animals. Over a total of 16 fibrillation-defibrillation episodes, a fibrillation threshold of about 3.8 mA/g was estimated. The lowest defibrillation values were, respectively, 43 mA/g and 507 mA/g, using rectangular pulses (less than 7 msec pulses width). There were also a few spontaneous reversals before and after defibrillation shocks. These cases point to our still poor understanding of the mechanisms involved in the process. It is suggested that reentry or multiple ectopic foci might not be the basic mechanisms, as traditionally accepted. Rather, it might well be a new behavior of the cells or group of cells like that predicted by the theory of deterministic chaos.
Savino
G V
GV
Instituto Superior de Investigaciones Biológicas, Consejo Nacional de Investigaciones Científicas y Técnicas, Tucumán, Argentina.
Valentinuzzi
M E
ME
D000818:Animals; D002025:Bufonidae / Q000502:physiology*; D004554:Electric Countershock; D004558:Electric Stimulation; D004562:Electrocardiography; D013045:Species Specificity; D014693:Ventricular Fibrillation / Q000503:physiopathology*; D016276:Ventricular Function