Formation and degradation of 1-(ethyl)-1-(2-hydroxyethyl) aziridinium chloride in aqueous media--a comparative NMR study.
The formation and decomposition of 1-(ethyl)-1-(2-hydroxyethyl) aziridinium chloride in aqueous media (10 mM solutions) was studied by NMR spectroscopy. Compared to 1-diethyl aziridinium chloride which lacks the hydroxyl group, the degradation of the title compound at 37 degrees C and pH = 7.4 is about 10 times faster. However, liquid nitrogen frozen solutions of both aziridinium salts are stable for long periods of time (1-6 months).
Goldstein
S
S
UCB S.A., Pharmaceutical Sector, Braine-l'Alleud, Belgium.
Grimee
R
R
Hanin
I
I
Wulfert
E
E
D001388:Aziridines; D001389:Azirines; D002794:Choline / Q000031:analogs & derivatives*; D004355:Drug Stability; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009466:Neuromuscular Blocking Agents; D012996:Solutions
D001388:Aziridines; D001389:Azirines; D009466:Neuromuscular Blocking Agents; D012996:Solutions; C044894:ethylcholine aziridinium; D002794:Choline