title: VLDL apoprotein secretion and apo-B mRNA level in primary culture of cholesterol-loaded rabbit hepatocytes.
abstract: Incubation of cultured rabbit hepatocytes with beta very low density lipoproteins (beta-VLDL) induces a dose-dependent increase in cell cholesterol (CH) content and VLDL apoprotein (apo) B and E secretion without change in apo-B mRNA level. These data suggest that beta-VLDL may exert a stimulatory effect on hepatic apo-B production at the co-translational and/or posttranslational level.
authors: USSR Cardiology Research Center, Academy of Medical Sciences, Moscow.
authors: V A
authors: VA
authors: Kosykh
authors: A P
authors: AP
authors: Surguchov
authors: E A
authors: EA
authors: Podres
authors: D K
authors: DK
authors: Novikov
authors: A B
authors: AB
authors: Sudarickov
authors: Berestetskaya YuV
authors: V S
authors: VS
authors: Repin
authors: V N
authors: VN
authors: Smirnov
mesh_terms: D000818:Animals; D001055:Apolipoproteins B / Q000235:genetics* / Q000378:metabolism; D001057:Apolipoproteins E / Q000378:metabolism; D001059:Apoproteins / Q000378:metabolism*; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism / Q000494:pharmacology*; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000378:metabolism*; D011817:Rabbits
chemical_list: D001055:Apolipoproteins B; D001057:Apolipoproteins E; D001059:Apoproteins; D008079:Lipoproteins, VLDL; D012333:RNA, Messenger; D002784:Cholesterol