Angiotensin receptor mediated regulation of transport in the rat proximal tubule.
The intracellular mechanism of Ang II action, as supported by the present data, may be summarized by the following: Ang II interacts with its receptors, leading to an increase in cytosolic Ca+2 by mobilization of Ca+2 from intracellular pools. This rise in cytosolic Ca+2 initiates the activation of calmodulin-regulated enzymes. This then leads to inhibition of both JV and JHCO3-.
Chan
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YL
Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago 60612.
Chatsudthipong
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V
Wang
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T
D015059:1-Sarcosine-8-Isoleucine Angiotensin II / Q000494:pharmacology; D000042:Absorption; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D002147:Calmodulin / Q000502:physiology; D003600:Cytosol / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000378:metabolism*; D008871:Microvilli / Q000378:metabolism; D051381:Rats; D011945:Receptors, Angiotensin / Q000502:physiology*; D014268:Trifluoperazine / Q000494:pharmacology
D001639:Bicarbonates; D002147:Calmodulin; D011945:Receptors, Angiotensin; D000804:Angiotensin II; D014268:Trifluoperazine; D015059:1-Sarcosine-8-Isoleucine Angiotensin II; D002118:Calcium