Hodgkin and Reed-Sternberg cell associated monoclonal antibodies HRS-1 and HRS-2 react with activated cells of lymphoid and monocytoid origin.
The two monoclonal antibodies HRS-1 and HRS-2, which were obtained after immunization with the Hodgkin's derived cell line L428, detect different epitopes on a 120 kd antigen. This antigen is present on Hodgkin- and Reed-Sternberg (H&RS) cells in all subtypes of Hodgkin's lymphoma and on large cell anaplastic non-Hodgkin's lymphomas. The H&RS- associated 120 kd antigen appears to be a non-lineage specific activation antigen, as it is not present on normal B and T lymphocytes or monocytes, but appears on these cells after activation. Because of their restricted reactivity with H&RS cells, HRS-1 and HRS-2 alone or in combination may be helpful for immunoimaging and immunotherapy of Hodgkin's lymphomas.
Pfreundschuh
M
M
Medizinische Universitätsklinik, Köln, F.R.G.
Mommertz
E
E
Meissner
M
M
Feller
A C
AC
Hassa
R
R
Krueger
G R
GR
Diehl
V
V
D000818:Animals; D000911:Antibodies, Monoclonal; D002460:Cell Line; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009000:Monocytes / Q000276:immunology*; D010641:Phenotype
D000911:Antibodies, Monoclonal