Congenital adrenal hyperplasia associated with hyperphosphatemic rickets.
The authors describe a boy with precocious puberty due to adrenal hyperplasia associated with rickets, hypocalcemia, hyperphosphatemia, elevated PTH and alkaline phosphatase levels, and concentrations of 25-OH-D and 1,25-(OH)2D at the upper limit or above normal range. Treatment with hydrocortisone for 9 months did not normalize hypocalcemia and hyperphosphatemia. The addition of 1,25-(OH)2D3 (0.5-2 micrograms/day) to the corticoid treatment for 1 year was followed by a progressive normalization of plasma calcium, phosphorus, PTH and alkaline phosphatase concentrations with improvement of the osteomalacia on bone biopsy.
Dumas
R
R
Service de Pédiatrie, Hôpital Saint Charles, Montpellier, France.
Garabedian
M
M
Belon
C
C
Sultan
C
C
Garandeau
P
P
Naoumis
A
A
D000312:Adrenal Hyperplasia, Congenital / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D002117:Calcitriol / Q000097:blood / Q000627:therapeutic use; D002648:Child; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D012279:Rickets / Q000097:blood / Q000150:complications* / Q000188:drug therapy
D010281:Parathyroid Hormone; D002117:Calcitriol; D006854:Hydrocortisone