In vivo evaluation of the genotoxic potential of curacron in somatic cells of mice.
Cytogenetic effects produced in somatic cells by Curacron, a phosphoric acid ester insecticide, were assessed in mice by three criteria: chromosome aberrations, sister chromatid exchange (SCE), and micronucleus induction. Curacron significantly increased the frequency of all three in an apparent dose-dependent manner. Curacron also inhibited the mitotic activity. The increased number of micronuclei is comparable to the increase in chromosome aberrations; the latter were mainly breaks. The frequency of SCE was considerably less than the frequencies of micronuclei and chromosome aberrations.
el Nahas
S M
SM
Unit of Cell Biology, National Research Centre, Cairo, Egypt.
de Hondt
H A
HA
Ramadan
A I
AI
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects* / Q000648:ultrastructure; D002869:Chromosome Aberrations; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D063086:Organothiophosphates / Q000494:pharmacology*; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; C024273:profenofos