Ketamine anaesthesia has no effect on striatal dopamine metabolism in rats.
Striatal levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid and homovanillic acid in rats were not altered for at least 6 h after a ketamine injection (100 mg/kg). Striatal DA turnover which was measured by giving alpha-methyl-p-tyrosine after ketamine was unchanged. Even the dose regimen of ketamine which anaesthetized animals for approximately 3.5 h (100 mg/kg + 5 maintenance injections of 50 mg/kg at 30 min intervals) produced no alteration in DA turnover for at least 9 h. These results suggest that ketamine anaesthesia will not adversely affect studies investigating central DAergic mechanisms in rats.
Koshikawa
N
N
Department of Pharmacology, Nihon University School of Dentistry, Tokyo, Japan.
Tomiyama
K
K
Omiya
K
K
Kobayashi
M
M
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000758:Anesthesia; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism; D007649:Ketamine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D015102:3,4-Dihydroxyphenylacetic Acid; D007649:Ketamine; D004298:Dopamine; D006719:Homovanillic Acid