Comparison of alkaline phosphatase activity in normal, lactating and neoplastic rat mammary tissue.
1. Alkaline phosphatase activity in NMU-induced rat mammary tumours was compared with activity in normal and lactating mammary gland. 2. Both tumour and normal mammary alkaline phosphatase were sensitive to heat inactivation and inhibition by phenylalanine. 3. Specific activity of enzyme in tumours was comparable to normal mammary tissue. 4. Mammary gland alkaline phosphatase increased markedly in late pregnancy and early lactation. 5. Bromocryptine treatment had no effect on enzyme activity in lactating mammary gland.
Colston
K W
KW
Department of Clinical Pathology, St George's Hospital Medical School, London, UK.
Hadcocks
L
L
Cleeve
H J
HJ
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D001667:Binding, Competitive; D001971:Bromocriptine / Q000494:pharmacology; D005260:Female; D007527:Isoenzymes / Q000378:metabolism; D007774:Lactation / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology*; D008770:Methylnitrosourea; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D007527:Isoenzymes; D001971:Bromocriptine; D008770:Methylnitrosourea; D000469:Alkaline Phosphatase