Distal axonopathy in streptozotocin diabetes in rats.
We noted the earliest morphological changes in the motor endplates 8 weeks after the induction of streptozotocin diabetes in rats. Morphometric measurements showed reduced axonal areas of the lateral plantar and the sciatic nerves in the diabetic rats 28 but not 2 and 8 weeks after the experiment. These findings suggested distal axonopathy.
Chokroverty
S
S
Neurology Service, VA Medical Center, Lyons, New Jersey 07939.
Seiden
D
D
Navidad
P
P
Cody
R
R
D000818:Animals; D001369:Axons / Q000473:pathology*; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D003929:Diabetic Neuropathies / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D009045:Motor Endplate / Q000473:pathology; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000473:pathology