title: [Histamine-receptor sensitivity of lymphocytes in patients with early and advanced stage breast cancer].
abstract: It is established that histamine in the concentration of 10(-4)-10(-5) M possesses an inhibitory effect in the lymphocyte adherence inhibition test in patients with breast cancer. Using specific antagonists (H1-blocker dimedrol and H2-blocker cimetidine) it is shown that the revealed histaminergic suppression of the lymphocyte adherence inhibition is mediated through the stimulating influence of histamine on H2-receptors.
authors: D D
authors: DD
authors: Kharkevich
authors: E B
authors: EB
authors: Polevaia
mesh_terms: D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology; D002927:Cimetidine / Q000494:pharmacology; D004155:Diphenhydramine / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D007957:Leukocyte Adherence Inhibition Test; D008214:Lymphocytes / Q000276:immunology*; D009367:Neoplasm Staging; D011968:Receptors, Histamine / Q000187:drug effects / Q000276:immunology*
chemical_list: D011968:Receptors, Histamine; D002927:Cimetidine; D006632:Histamine; D004155:Diphenhydramine
vernacular_title: Gistaminoretseptornaia chuvstvitel'nost' limfotsitov krovi bol'nykh rakom molochnoĭ zhelezy v rannie i pozdnie stadii.