title: The effects of menthol isomers on nasal sensation of airflow.
abstract: The effects of inhalation of L-menthol, D-isomenthol and D-neomenthol, upon nasal resistance and sensation to airflow were investigated in 40 subjects. L-menthol caused a highly significant enhancement of nasal sensation of airflow but despite their great similarity in structure and a similar peppermint smell the isomers D-isomenthol and D-neomenthol had no effect on nasal sensation of airflow. These findings show that L-menthol has a specific pharmacological action on nasal sensory nerve endings which is not related to its peppermint smell.
authors: Department of Physiology, University College, Cardiff.
authors: R
authors: R
authors: Eccles
authors: D H
authors: DH
authors: Griffiths
authors: C G
authors: CG
authors: Newton
authors: N S
authors: NS
authors: Tolley
mesh_terms: D000293:Adolescent; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006801:Humans; D008297:Male; D008610:Menthol / Q000494:pharmacology*; D012677:Sensation / Q000187:drug effects*; D011984:Sensory Receptor Cells / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: D008610:Menthol