Interference to oral superinfection of Aedes triseriatus infected with La Crosse virus.
Aedes triseriatus orally infected with a temperature-sensitive mutant of La Crosse virus were, at predetermined times post-infection, orally challenged with wild type La Crosse or Tahyna virus. Most mosquitoes challenged with wild type La Crosse virus within 24 hr of ingestion of the temperature-sensitive virus became superinfected. In contrast, the majority of mosquitoes challenged at 72 hr were resistant to superinfection. Mosquitoes challenged at 7 days or thereafter were refractory to superinfection with La Crosse or Tahyna virus. The onset of interference was correlated with virus titer and antigen expression in midgut cells.
Sundin
D R
DR
Department of Microbiology, Colorado State University, Fort Collins 80523.
Beaty
B J
BJ
D000330:Aedes / Q000382:microbiology*; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002043:Bunyaviridae / Q000254:growth & development*; D004064:Digestive System / Q000382:microbiology; D002141:Encephalitis Virus, California / Q000235:genetics / Q000254:growth & development* / Q000276:immunology; D009154:Mutation; D013997:Time Factors; D014762:Viral Interference
D000956:Antigens, Viral