SK-UT-1B, a human tumorigenic diploid cell line.
SK-UT-1B (ATCC HTB 115) produced tumors 2 weeks after subcutaneous injection of 10 million cells into athymic nude mice. Karyotypic analysis at the 500-600 subband level, however, did not reveal any noticeable aberrations. This cell line therefore may represent the first example of experimentally proven human tumorigenic cells of solid tumor origin that retains the diploid karyotype in vitro indefinitely.
Chen
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American Type Culture Collection, Rockville, Maryland 20852.
D000368:Aged; D000818:Animals; D004171:Diploidy; D005260:Female; D006801:Humans; D007621:Karyotyping; D007890:Leiomyosarcoma / Q000235:genetics / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured / Q000473:pathology; D014594:Uterine Neoplasms / Q000235:genetics / Q000473:pathology