Suramin: a reversible P2-purinoceptor antagonist in the mouse vas deferens.
The trypanocide Suramin was tested as a possible antagonist at the P2-purinoceptor of the mouse vas deferens. At a concentration of 100 microM, Suramin antagonized the response to alpha,beta-methylene ATP, while responses to carbachol and noradrenaline were unaffected. These results suggest that Suramin may provide a starting point for the development of specific antagonists for P2-purinoceptors.
Dunn
P M
PM
Department of Physiology, University of Leicester.
Blakeley
A G
AG
D000244:Adenosine Diphosphate / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011983:Receptors, Purinergic / Q000187:drug effects*; D013498:Suramin / Q000494:pharmacology*
D011983:Receptors, Purinergic; C523965:alpha,beta-methyleneadenosine 5'-diphosphate; D013498:Suramin; D000244:Adenosine Diphosphate