In vitro effects of anthraquinones on rat intestine and uterus.
Isolated uterus and colon segments were taken from sennoside-pretreated female rats. They indicate a possible decrease in spontaneous contractility of both organ segments. Addition of rhein-Na, as one of the probable active metabolites of sennosides, into the bath medium of isolated colon and ileum segments of untreated rats showed a reduction in contractility at concentrations of more than 10(-5) and 10(-4) mol/l, respectively. Though rhein-Na in concentrations of more than 10(-4) mol/l impaired acetylcholine-mediated contractures of isolated colon, the antagonism was obviously partial and noncompetitive. Isolated uteri from previously estrogen-treated rats did not show a change in the contractile behaviour up to concentrations of 10(-4) mol/l rhein-Na, whereas higher concentrations induced an increase in contractions. The importance of this finding is not clear.
Odenthal
K P
KP
Department of Pharmacology, Dr. Madaus GmbH & Co., Cologne, FRG.
Ziegler
D
D
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects / Q000502:physiology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D012676:Senna Extract; D000081226:Sennosides; D014590:Uterine Contraction / Q000187:drug effects*
D000880:Anthraquinones; D000081226:Sennosides; D012676:Senna Extract; D000109:Acetylcholine; C020491:rhein