Evidence against a dependence of the senna effect on prostaglandin formation.
The laxation induced by senna is not modified in rats either maintained on a diet deficient in essential fatty acids (EFAD) or exposed to cold (6 degrees C) or with yeast-induced fever. In light of our findings it appears conceivable that non-PG-mediated mechanism(s) play a relevant role in laxation induced by senna.
Mascolo
N
N
Department of Experimental Pharmacology, University of Naples, Italy.
Meli
R
R
Autore
G
G
Capasso
F
F
D000818:Animals; D003080:Cold Temperature; D003106:Colon / Q000187:drug effects / Q000378:metabolism; D005228:Fatty Acids, Essential / Q000172:deficiency; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D012676:Senna Extract / Q000494:pharmacology*
D005228:Fatty Acids, Essential; D011453:Prostaglandins; D012676:Senna Extract