Activity of interferon beta in condylomata with dysplastic lesion of the uterine cervix.
The effectiveness of interferon beta in the treatment of condylomata of the cervico-vaginal tract associated with CINs was evaluated in 25 patients. Human fibroblastic interferon (IFN beta) was administered by intra and perilesional infiltration at a dosage of 3 x 10(6) IU/day for 5 consecutive days the first week and every other day the second. The treatment showed: complete regression in 61.76% of CIN I and 58.69% of CIN II; partial regression in 26.47% of CIN I and 21.73% of CIN II. The picture remained unvaried in 11.76% of CIN I and 19.56% of CIN II.
Puligheddu
P
P
Institute of Obstetrics and Gynecology, University of Cagliari, Italy.
Marcello
C
C
Medda
F
F
Parodo
G
G
Setzu
A
A
Lecca
U
U
D000293:Adolescent; D000328:Adult; D003218:Condylomata Acuminata / Q000628:therapy*; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D002578:Uterine Cervical Dysplasia / Q000628:therapy*; D014625:Vaginal Neoplasms / Q000628:therapy
D007370:Interferon Type I