Genetic factors involved in human G gamma and A gamma globin gene expression.
G gamma to A gamma globin ratios, haplotypes at the beta globin gene cluster and the C----T substitution at -158 5' to the G gamma globin gene were studied in three Algerian families that include SS or S-beta(0) thal patients. G gamma to A gamma ratios were found similar, within a family, in subjects displaying the same combination of chromosomes 11, the ratio observed for a given combination depending on the chromosome haplotypes. Our data can be explained by the existence of several alleles of a genetic factor closely linked to the beta globin gene cluster and involved in the determination of G gamma to A gamma globin ratio.
Bouhass
R
R
Institut National d'Etudes Supérieures en Sciences Médicales, Service de Pédiatrie, Centre Emir Abdelkader, Oran, Algérie.
Taleb-Bendiab
R
R
Starck
J
J
Morle
F
F
Aguercif
M
M
Godet
J
J
D000755:Anemia, Sickle Cell / Q000235:genetics; D002880:Chromosomes, Human, Pair 11; D005796:Genes; D005914:Globins / Q000235:genetics*; D006801:Humans; D010375:Pedigree; D013789:Thalassemia / Q000235:genetics
D005914:Globins