[The renin-angiotensin-aldosterone system and antidiuretic hormone secretion during plasmapheresis in patients with high arterial hypertension refractory to drug therapy].
Plasmapheresis (PP) was used in 28 patients with medication-resistant high arterial hypertension (AH). PP-induced changes in plasma renin activity and blood aldosterone, angiotensin II and antidiuretic hormone levels of patients with high AH are shown to be a compensatory-adaptive response, maintaining homeostasis. PP sessions (27 ml/kg body weight at a rate of 0.22 ml/kg/min, at the maximum) do not produce renin-angiotensin-aldosterone activation. Long-term hypotensive effect of PP in cases of high AH might be related to a gradual decrease in blood angiotensin II and systemic aldosterone synthesis. It is suggested that the hypotensive effect of PP may be due to an intricate interaction of effects, with humoral, receptor and circulatory re-adjustments of arterial BP control being the most prominent among those.
Kukharchuk
V V
VV
Legkonogov
A V
AV
Kutsenko
A I
AI
Masenko
V P
VP
Arabidze
G G
GG
D000328:Adult; D002908:Chronic Disease; D004351:Drug Resistance; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy*; D006974:Hypertension, Malignant / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis / Q000379:methods; D012084:Renin-Angiotensin System; D013997:Time Factors; D014667:Vasopressins / Q000378:metabolism*
D014667:Vasopressins
Sostoianie renin-angiotenzin-al'dosteronovoĭ sistemy i sekretsiia antidiureticheskogo gormona pri plazmafereze u bol'nykh vysokoĭ arterial'noĭ gipertonieĭ, refrakternoĭ k medikamentoznoĭ terapii.