Decomposition of aspirin in the solid state in the presence of limited amounts of moisture III: Effect of temperature and a possible mechanism.
In a previous study, we showed that aspirin in the presence of limited amounts of moisture falls to follow Leeson-Mattocks kinetics at 62.5 degrees C. This system has been tested at a series of temperatures, and several plausible models have been tested. It is shown that the data are explained by a model in which the reaction is limited to a surface interaction between aspirin and water from the sorbed bulk moisture layer.
Carstensen
J T
JT
School of Pharmacy, University of Wisconsin, Madison 53706.
Attarchi
F
F
D001241:Aspirin / Q000032:analysis*; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D008954:Models, Biological; D013696:Temperature
D001241:Aspirin