[Significance of basal TSH and free T3 as compared with an extended in vitro diagnosis in the understanding of functional disorders of the thyroid].
Data of 411 untreated patients undergoing thyroid investigations were stored in a data base system. Three combinations of thyroidal hormone parameters were compared with respect to their clinical value. In patients with concordant basal TSH (bTSH) and free T3 (fT3)-values (e.g. bTSH normal and fT3 normal, bTSH decreased and fT3 increased) it could be demonstrated that the predictive value of the combined evaluation of basal TSH (supersensitive) and free T3 alone (97% in normal thyroid function, 98% in thyrotoxicosis, and 97% in hypothyroidism) was sufficient. Additional determinations of T4 parameters did not increase predictive value (e.g. TT4: 95% in thyrotoxicosis). Thus, thyroid disorders may currently be diagnosed by the combined evaluation of basal TSH and free T3, saving costs without loss of diagnostic efficacy.
Kleinhans
E
E
Abteilung Nuklearmedizin, RWTH Aachen, Klinikum Aachen, BRD.
Griese
M
M
Meyers
W
W
Weiller
G
G
Büll
U
U
D019411:Clinical Laboratory Techniques / Q000191:economics; D003365:Costs and Cost Analysis; D006801:Humans; D013960:Thyroid Function Tests / Q000379:methods*; D013972:Thyrotropin / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D013972:Thyrotropin
Die Aussagekraft von basalem TSH und freiem T3 im Vergleich zur erweiterten In-vitro-Diagnostik bei der Erkennung von Schilddrüsenfunktions-störungen.