Successful treatment of atypical sprue in an infant with cyclosporine.
Cyclosporine was used to treat a child with severe, atypical sprue that was unresponsive to diet, parenteral nutrition, and corticosteroids. Therapy with cyclosporine resulted in a prompt clinical, functional, and histologic recovery. Remission was maintained for 1 yr until the drug was discontinued, when there was a histologic relapse that responded to reinstituting drug therapy. Cyclosporine may provide effective therapy for patients with similar disease.
Bernstein
E F
EF
Department of Pediatrics, University of Chicago Pritzker School of Medicine, Wyler Children's Hospital, Illinois.
Whitington
P F
PF
D002446:Celiac Disease / Q000178:diet therapy / Q000188:drug therapy* / Q000473:pathology; D003524:Cyclosporins / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007583:Jejunum / Q000473:pathology; D008297:Male
D003524:Cyclosporins