Large-scale resolution of gossypol enantiomers for biological evaluation.
Gossypol has been resolved into its pure optical isomers by conversion into the Schiff's base derivative of (+)-phenylalanine methyl ester, normal or reverse phase chromatography and hydrolysis. Forty grams of pure (-)-gossypol has been prepared in a micronised form for assessment of its antifertility and toxicological effects.
Matlin
S A
SA
Chemistry Department, The City University, London, UK.
Zhou
R H
RH
Belenguer
A
A
Tyson
R G
RG
Brookes
A N
AN
D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D005298:Fertility / Q000187:drug effects*; D006072:Gossypol / Q000032:analysis* / Q000494:pharmacology; D007536:Isomerism; D008297:Male; D008647:Mesocricetus; D012545:Schiff Bases / Q000138:chemical synthesis
D012545:Schiff Bases; D006072:Gossypol