Uptake of artificial model remnant lipoprotein emulsions by the perfused rat liver.
In comparison with their precursor lipoproteins, the remanants of the triacylglycerol-rich lipoproteins are reduced in contents of triacylglycerols and apolipoproteins AI and AIV, whereas the contents of cholesterol (free and esterified) and apolipoprotien E are increased. In this study, lipid emulsion models of remnant lipoproteins were used to explore which of these factors are necessary for physiological rates of remnant uptake by the perfused rat liver. Uptake rates of lipid emulsion models of remnant lipoproteins in the presence of apolipoprotein E were similar to in vivo uptake rates.
Redgrave
T G
TG
Biophysics Institute, Housman Medical Research Center, Boston University School of Medicine, MA 02118.
Maranhao
R C
RC
Tercyak
A M
AM
Lincoln
E C
EC
Brunengraber
H
H
D000818:Animals; D001053:Apolipoproteins / Q000302:isolation & purification / Q000494:pharmacology; D002914:Chylomicrons / Q000302:isolation & purification; D004655:Emulsions; D066298:In Vitro Techniques; D008074:Lipoproteins / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008854:Microscopy, Electron; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D001053:Apolipoproteins; D002914:Chylomicrons; D004655:Emulsions; D008074:Lipoproteins