Radioreceptor assay and high-performance liquid chromatography yield similar results for serum thioridazine and its major metabolites.
Thioridazine and its major metabolites were quantified in serum of thioridazine-treated psychiatric patients by radioreceptor assay and high performance liquid chromatography (HPLC) every second day during 3 weeks of drug administration. Serum neuroleptic levels measured by radioreceptor assay and serum concentrations of thioridazine and its active metabolites estimated by HPLC correlated (r = 0.82, n = 60); the intra- and interassay coefficients of variation of both assays were low (less than 7%). Thus, serum thioridazine can be adequately monitored by radioreceptor assay as well as by HPLC.
Rao
M L
ML
Nervenklinik, Psychiatrie, Universität Bonn, F.R.G.
Brown
W A
WA
Wagner
R
R
D000328:Adult; D000928:Antidepressive Agents / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008653:Mesoridazine / Q000097:blood; D010640:Phenothiazines / Q000097:blood; D011869:Radioligand Assay; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy; D013881:Thioridazine / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use
D000928:Antidepressive Agents; D010640:Phenothiazines; D008653:Mesoridazine; C040634:sulforidazine; D013881:Thioridazine