title: An evaluation of the role of surgery in metastatic neuroblastoma.
abstract: The role of surgery was evaluated in 320 patients with metastatic neuroblastoma (Children's Cancer Study Group [CCSG] stage IV, excluding IV-S) enrolled in two CCSG treatment protocols between June 1978 and November 1982. The regimens consisted of combination chemotherapy, radiation therapy, and surgery. Two hundred seventy-seven surgical procedures were performed in 214 of the 320 eligible patients. Surgical intervention at the primary site was performed at initiation of therapy in 86 patients. There was a slight survival advantage when complete resection of the primary tumor was achieved (P = .09). Delayed surgery was performed in 89 patients. Gross complete resection of primary tumor was feasible in 57 of these patients (64.0%). However, survival analysis showed that resolution of metastases had a more important impact on subsequent length of survival than resectability at the delayed procedure (P = .005).
authors: Children's Cancer Study Group, Pasadena, CA.
authors: M
authors: M
authors: Matsumura
authors: J B
authors: JB
authors: Atkinson
authors: D M
authors: DM
authors: Hays
authors: G D
authors: GD
authors: Hammond
authors: S E
authors: SE
authors: Siegel
authors: H
authors: H
authors: Sather
authors: J
authors: J
authors: Grosfeld
authors: G
authors: G
authors: Haase
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009447:Neuroblastoma / Q000401:mortality / Q000556:secondary* / Q000601:surgery