The effect of metoclopramide on the absorption of oral controlled release morphine.
The pharmacokinetics of oral controlled release morphine and metoclopramide were investigated in 20 patients in a double-blind, randomly allocated study. The concurrent administration of metoclopramide and oral controlled release morphine led to a faster onset and increased level of sedation compared with the administration of oral controlled release morphine alone. Whilst the increased sedation may be advantageous in anaesthetic practice, it may be a potential problem in patients starting longer term therapy with these drugs.
Manara
A R
AR
Department of Anaesthesia, Addenbrookes Hospital, Cambridge.
Shelly
M P
MP
Quinn
K
K
Park
G R
GR
D000284:Administration, Oral; D000368:Aged; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy
D003692:Delayed-Action Preparations; D009020:Morphine; D008787:Metoclopramide