Omega-conotoxin GVIA and pharmacological modulation of hippocampal noradrenaline release.
The tritium overflow evoked by electrical stimulation of rabbit hippocampal slices labeled with [3H]noradrenaline was inhibited by omega-conotoxin GVIA, a peptide modulator of the N-type voltage-sensitive calcium channel (N-VSCC). The magnitude of this inhibition was unchanged in the presence of substances which interact with N- and/or L-VSCCs (cadmium, neomycin, (-)- and (+)-202-791), alpha 2-adrenoceptors (idazoxan, UK-14304), protein kinase C (4 beta-phorbol-12,13-dibutyrate) or potassium channels (4-aminopyridine). This finding suggests that the attenuation of calcium-dependent neurotransmitter release by omega-conotoxin GVIA is relatively insensitive to alterations of such release effected by other substances.
Dooley
D J
DJ
Gödecke Research Institute, Freiburg, F.R.G.
Lupp
A
A
Hertting
G
G
Osswald
H
H
D000631:Aminopyridines / Q000494:pharmacology; D000818:Animals; D000068438:Brimonidine Tartrate; D002104:Cadmium / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004146:Dioxanes / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D019329:Idazoxan; D066298:In Vitro Techniques; D008978:Mollusk Venoms / Q000494:pharmacology*; D009355:Neomycin / Q000494:pharmacology; D009539:Nicotinic Acids / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D010069:Oxadiazoles; D010703:Phorbol Esters / Q000494:pharmacology; D011810:Quinoxalines / Q000494:pharmacology; D011817:Rabbits; D020866:omega-Conotoxin GVIA
D000631:Aminopyridines; D002121:Calcium Channel Blockers; D004146:Dioxanes; D008978:Mollusk Venoms; D009539:Nicotinic Acids; D010069:Oxadiazoles; D010703:Phorbol Esters; D011810:Quinoxalines; D002104:Cadmium; C049834:PN 202-791; D000068438:Brimonidine Tartrate; D020866:omega-Conotoxin GVIA; D009355:Neomycin; D009638:Norepinephrine; D019329:Idazoxan