Regional blood flow in human tumours measured with argon, krypton and xenon.
Blood perfusion in 19 superficial tumour metastases was measured by injecting three tracers, 41Ar, 85Krm and 135Xe or 133Xe, simultaneously into the tissue. The blood flow rate was calculated from the constants of the biexponential functions fitted to the measured counts. The mean blood flow in the 19 tumours studied was 18 ml/(100 g min) (SD +/- 10). Alternatively, the relative partition coefficients of argon, krypton and xenon were calculated from the equations obtained using compartmental analysis. The mean values for the ratios of the partition coefficients of these nuclides were found to be between 0.82 and 1.07.
Mäntylä
M
M
Department of Radiotherapy and Oncology, University Central Hospital, Helsinki, Finland.
Heikkonen
J
J
Perkkiö
J
J
D001128:Argon; D006801:Humans; D007727:Krypton Radioisotopes; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012039:Regional Blood Flow; D014980:Xenon Radioisotopes
D007727:Krypton Radioisotopes; D011868:Radioisotopes; D014980:Xenon Radioisotopes; D001128:Argon