title: Combined manometric and radiological study of the changes in colonic motility induced by sennosides in rats.
abstract: Colonic motility changes induced by sennosides in rats were studied by an original method, which permits the simultaneous projection of manometric and fluoroscopic registrations on a single monitor. The results of this study allowed us to confirm the laxative effect of sennosides by inducing mass movements within 60-80 min after intracecal administration leading to a complete emptying of the whole colon. These mass movements were preceded by hypotonia of cecum and colon and impeded pellet formation.
authors: Department of Pharmaceutical Biology and Phytopharmacology, K.U. Leuven, Belgium.
authors: C
authors: C
authors: Spiessens
authors: L
authors: L
authors: Ceuterick
authors: E
authors: E
authors: Ponette
authors: J
authors: J
authors: Janssens
authors: J
authors: J
authors: Lemli
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology*; D003106:Colon / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D008365:Manometry; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains; D012676:Senna Extract; D000081226:Sennosides; D013997:Time Factors
chemical_list: D000880:Anthraquinones; D000081226:Sennosides; D012676:Senna Extract