Egg white-specific IgE and IgG subclass antibodies and their associations with clinical egg hypersensitivity.
The data obtained so far indicate that 1) presence of high titer of IgE antibodies was related with symptoms of egg hypersensitivity, 2) it seems unlikely that increased IgG4 antibody levels against egg white is a cause of egg hypersensitivity, and one should pay much attention to IgG1 antibodies, instead, 3) it is possible that increased IgG4 may reduce the effect of complement-fixing antibodies like IgG1 and/or interfere the action of IgE antibodies.
Nakagawa
T
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Department of Medicine, School of Medicine, University of Tokyo, Japan.
D000328:Adult; D000918:Antibody Specificity; D000936:Antigen-Antibody Complex / Q000378:metabolism; D001249:Asthma / Q000276:immunology; D002648:Child; D004529:Egg White / Q000009:adverse effects*; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology*; D007074:Immunoglobulin G / Q000145:classification* / Q000276:immunology / Q000378:metabolism
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007073:Immunoglobulin E