title: Pharmacokinetic and taste evaluation of ibuprofen (Motrin) 800 mg tablets in extemporaneous solution.
abstract: A 4-way crossover study was done to determine the pharmacokinetic and palatability characteristics of ibuprofen 800 mg tablets when given as a solution in various beverages. When compared to the tablet itself, no significant difference was noted for any variable measured for an orange juice solution. A delay in time-to-peak concentration (Tmax) was noted for a dilute cherry syrup solution. Changes in Tmax, peak concentration achieved and area-under-the-curve were noted with a Coca-Cola solution. The authors conclude Coca-Cola to be clearly inappropriate for this method, a dilute cherry syrup solution slightly better and orange juice to be the preferred option.
authors: Department of Pharmacy and Pharmaceutics, Medical College of Virginia, Virginia Commonwealth University, Richmond.
authors: R E
authors: RE
authors: Small
authors: S M
authors: SM
authors: Johnson
authors: H E
authors: HE
authors: Willis
mesh_terms: D000328:Adult; D001682:Biological Availability; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D009994:Osmolar Concentration; D012996:Solutions; D013649:Taste; D013997:Time Factors
chemical_list: D012996:Solutions; D007052:Ibuprofen