Liver aspartate aminotransferase activity as a power function of body weight.
Total liver enzyme activity (E) for aspartate aminotransferase (ASAT; EC 2.6.1.1) per gram body weight (W) decreases in six species as body weight increases from mice to cattle according to the equation E/W 0.85 = c, where c is a constant. The 0.85 power of body weight thereby provides a reference standard for the direct arithmetic comparison of liver ASAT activities in six species with different body weights. The use of W 0.85 should provide a tool in clinical studies in which data from experimental animals must be related to humans, e.g., in establishing the relationship between drug dosage (or toxicity) and body weight.
Pappas
N J
NJ
Department of Research, Wm. Jennings Bryan Dorn Veterans Hospital Medical Center, Columbia, South Carolina.
Qureshi
A R
AR
D000328:Adult; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D001835:Body Weight; D002417:Cattle; D004285:Dogs; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D001219:Aspartate Aminotransferases