title: Gravitational independence of single-breath washout tests in recumbent dogs.
abstract: To examine the mechanisms of lung filling and emptying, Ar-bolus and N2 single-breath washout tests were conducted in 10 anesthetized dogs (prone and supine) and in three of those dogs with body rotation. Transpulmonary pressure was measured simultaneously, allowing identification of the lung volume above residual volume at which there was an inflection point in the pressure-volume curve (VIP). Although phase IV for Ar was upward, phase IV for N2 was small and variable, especially in the prone position. No significant prone to supine differences in closing capacity for Ar were seen, indicating that airway closure was generated at the same lung volumes. The maximum deflections of phase IV for Ar and N2 from extrapolated phase III slopes were smaller in the prone position, suggesting more uniform tracer gas concentrations across the lungs. VIP was smaller than the closing volume for Ar, which is consistent with the effects of well-developed collateral ventilation in dogs. Body rotation tests in three dogs did not generally cause an inversion of phase III or IV. We conclude that in recumbent dogs regional distribution of ventilation is not primarily determined by the effect of gravity, but by lung, thorax, and mediastinum interactions and/or differences in regional mechanical properties of the lungs.
authors: Department of Medicine, University of California, San Diego, La Jolla 92093.
authors: S
authors: S
authors: Tomioka
authors: S
authors: S
authors: Kubo
authors: H J
authors: HJ
authors: Guy
authors: G K
authors: GK
authors: Prisk
mesh_terms: D000818:Animals; D004285:Dogs; D006112:Gravitation; D008168:Lung / Q000502:physiology*; D011187:Posture; D012119:Respiration; D012129:Respiratory Function Tests / Q000379:methods