title: Fetal growth and fetal lung phospholipid content in rats fed safflower oil, menhaden oil, or hydrogenated coconut oil.
abstract: The objective was to determine if dietary fish oil decreased the degree of fatty acid saturation in rat lung phosphatidylcholine (PC). A diet containing 12% of its energy as fat was fed for 3 wk to growing male Sprague-Dawley rats (trial I) or to pregnant rats for days 8-21 of gestation (trial II). The dietary fat treatments in trial I were safflower oil (SO), menhaden oil (MO), or hydrogenated coconut oil (HCO) and in trial II were SO, MO, HCO, or SO-MO (75%:25%). Polyunsaturated fatty acids reduced (p less than 0.05) hepatic fatty acid synthetase (MO greater than SO) in growing rats but the dietary lipids had no effect on lung palmitate content. Maternal consumption of MO vs SO reduced (p less than 0.05) fetal body weight and lung weight but not lung:body wt ratio. Dietary MO and SO-MO increased (p less than 0.05) disaturated PC content of fetal lungs. The fetal lung data indicate that maternal ingestion of fish oil improve fetal lung maturation.
authors: Graduate Program of Nutrition, University of Minnesota, St Paul.
authors: S D
authors: SD
authors: Clarke
authors: L
authors: L
authors: Benjamin
authors: L
authors: L
authors: Bell
authors: S D
authors: SD
authors: Phinney
mesh_terms: D000818:Animals; D000074263:Coconut Oil; D004041:Dietary Fats / Q000494:pharmacology*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D064429:Fatty Acid Synthases / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology; D008168:Lung / Q000032:analysis / Q000196:embryology*; D008297:Male; D008431:Maternal-Fetal Exchange; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism; D010713:Phosphatidylcholines / Q000032:analysis; D010714:Phosphatidylethanolamines / Q000032:analysis; D010716:Phosphatidylinositols / Q000032:analysis; D010743:Phospholipids / Q000032:analysis*; D010938:Plant Oils / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012450:Safflower Oil / Q000494:pharmacology*
chemical_list: D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D010169:Palmitic Acids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010716:Phosphatidylinositols; D010743:Phospholipids; D010938:Plant Oils; C033266:Menhaden oil; D019308:Palmitic Acid; D012450:Safflower Oil; D064429:Fatty Acid Synthases; D000074263:Coconut Oil