Magnetic urokinase: targeting of urokinase to fibrin clot.
A plasminogen activator of human origin, urokinase, was endowed with magnetic property. The magnetic urokinase was composed of magnetite, polyethylene glycol derivative and urokinase, and dispersed in saline. Its particle size of magnetite was approximately 30-60 nm. It was selectively delivered to fibrin clot by magnetic force in continuously circulating plasma and exerted fibrinolytic activity without degrading fibrinogen.
Yoshimoto
T
T
Laboratory of Biological Chemistry, Tokyo Institute of Technology, Japan.
Ohwada
K
K
Takahashi
K
K
Matsushima
A
A
Saito
Y
Y
Inada
Y
Y
D001780:Blood Coagulation Tests / Q000295:instrumentation / Q000379:methods; D052203:Ferrosoferric Oxide; D005342:Fibrinolysis; D005343:Fibrinolytic Agents / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007501:Iron / Q000097:blood / Q000494:pharmacology*; D010087:Oxides; D011092:Polyethylene Glycols / Q000494:pharmacology; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood / Q000494:pharmacology*
D005343:Fibrinolytic Agents; D010087:Oxides; D011092:Polyethylene Glycols; D007501:Iron; D014568:Urokinase-Type Plasminogen Activator; D052203:Ferrosoferric Oxide