An improved method of vancomycin administration to dialysis patients.
Vancomycin is a nondialyzable antibiotic frequently used by patients on hemodialysis. Traditionally, a 1-gram dose is administered at the conclusion of dialysis. Recent rate-related side effects have prompted the manufacturer to revise the package insert suggesting a maximum infusion rate of 500 mg/h; necessitating a two-hour infusion post-dialysis. We evaluated the safety and efficacy of vancomycin administered during dialysis in nine chronic hemodialysis patients in an open crossover study. All patients received vancomycin during and post-dialysis in consecutive weeks. Therapeutic peak and trough serum concentrations were achieved in all patients. No adverse reactions occurred.
Edell
L S
LS
Pharmacy-Drug Information, Crozer-Chester Medical Center, PA.
Westby
G R
GR
Gould
S R
SR
D000328:Adult; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D006435:Renal Dialysis; D014640:Vancomycin / Q000008:administration & dosage* / Q000627:therapeutic use
D014640:Vancomycin