title: Class-specific antibody responses in school children vaccinated with an A/Brazil/11/78 (H1N1)-like recombinant influenza virus prepared from the A/Leningrad/134/57 paediatric cold-adapted donor strain.
abstract: Forty-three school children from 8 to 11 years old were vaccinated intranasally with two doses of a paediatric attenuated influenza vaccine developed by reassortment between cold-adapted A/Leningrad/134/57(H2N2) and an A/Brazil/11/78(H1N1)-like strain. Two vaccine doses were administered 1 month apart in a randomized, blind, placebo-controlled study. Although the first vaccine dose had a low infectivity titre, overall 65% of children who received two doses of vaccine showed serological evidence of infection by HI tests. Serum IgA antibody responses against the vaccine strain were detected in nearly 50% of the vaccines and serum IgG antibody responses were detected in approximately equal to 40% by an enzyme immunoassay.
authors: D.I Ivanovsky Institute of Virology, Academy of Medical Sciences of the USSR, Moscow.
authors: A N
authors: AN
authors: Slepushkin
authors: P A
authors: PA
authors: Patriarca
authors: N P
authors: NP
authors: Obrosova-Serova
authors: M W
authors: MW
authors: Harmon
authors: L N
authors: LN
authors: Kupryashina
authors: S G
authors: SG
authors: Cheshik
authors: R B
authors: RB
authors: Vartanyan
authors: G I
authors: GI
authors: Alexandrova
authors: F I
authors: FI
authors: Polezhaev
authors: N I
authors: NI
authors: Lonskaya
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis*; D000918:Antibody Specificity; D002648:Child; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D053118:Influenza A Virus, H1N1 Subtype; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D011995:Recombination, Genetic; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007252:Influenza Vaccines