title: Comparative evaluation of two direct compression lactose grades for pyridoxine hydrochloride tablets.
abstract: Fast flow lactose (FFL) and anhydrous lactose (AHL) were comparatively investigated for the manufacture of pyridoxine hydrochloride tablets. The results showed that drug/FFL formulations possessed better performance. Harder tablets were, however, compressed from AHL blends. Linear relationships which correlate tablet physical properties to excipient concentration in a given formulation were established. Tablet batches formulated with FFL dissolved in shorter times und showed better stability characteristics on aging.
authors: Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka.
authors: S A
authors: SA
authors: Aly
authors: O K
authors: OK
authors: Udeala
mesh_terms: D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D004356:Drug Storage; D005079:Excipients; D006244:Hardness; D007785:Lactose / Q000032:analysis*; D011736:Pyridoxine / Q000032:analysis*; D012995:Solubility; D013607:Tablets; D013696:Temperature; D014815:Vitamins / Q000032:analysis
chemical_list: D005079:Excipients; D013607:Tablets; D014815:Vitamins; D007785:Lactose; D011736:Pyridoxine