Pharmacokinetics of ketamine HCl and metabolite I in the cat: a comparison of i.v., i.m., and rectal administration.
Ketamine HCl [2-(o-chlorophenyl)-2-(methylamino) cyclohexanone HCl] concentrations in whole blood were used to study the pharmacokinetics of i.v., i.m., and rectal administrations, at a dose of 25 mg/kg, in normal domestic cats. Absorption was rapid with both the i.m. and rectal routes. Systemic availability was 51% (SEM 10) for the i.m. dose and 43.5% (SEM 6.1) for the rectal dose. The first-pass effect had a minimal influence on the metabolism of ketamine HCl administered rectally. The elimination rate constant (beta) of the drug was statistically similar in the i.v., i.m., and rectal groups, at a 95% level of significance (P less than 0.05). At the dosage rates studied, ketamine HCl produced an anesthetic effect in the cat following i.v., i.m. and rectal administration.
Hanna
R M
RM
Department of Veterinary & Comparative Anatomy, Pharmacology, Physiology, College of Veterinary Medicine, Washington State University, Pullman.
Borchard
R E
RE
Schmidt
S L
SL
D000285:Administration, Rectal; D000818:Animals; D002415:Cats / Q000378:metabolism*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007649:Ketamine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*
D007649:Ketamine