[Effect of a conditioned medium of pinealocytes on prolactin secretion in primary culture of adenohypophyseal cells of male rats].
Conditioned medium of pinealocytes (CMP, 18-20%) added to primary cultures of rat pituitary cells for 1.5 h changed neither the basal rate of PRL secretion nor dopamine-inhibited release. However CMP markedly attenuated PRL secretion induced by thyroliberin or isobutyl-menthylxanthine. Besides CMP reduced basal PRL release during 18-h-incubation. The results obtained indicate possible involvement of the pineal gland in direct inhibitory control of PRL secretion in male rats.
Gudoshnikov
V I
VI
Komolov
I S
IS
Fazekash
I
I
Fedotov
V P
VP
D000818:Animals; D002417:Cattle; D002457:Cell Extracts / Q000494:pharmacology; D002478:Cells, Cultured; D003470:Culture Media; D008297:Male; D010870:Pineal Gland / Q000166:cytology / Q000502:physiology*; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D002457:Cell Extracts; D003470:Culture Media; D011388:Prolactin
Vliianie konditsionirovannoĭ sredy pinealotsitov na sekretsiiu prolaktina v pervichnoĭ kul'ture adenogiopfizarnykh kletok samtsov krys.