Role of humoral immunity in progressive and regressive and metastatic growth of the canine transmissible venereal sarcoma.
Canine transmissible venereal sarcoma (CTVS) is a contagious neoplasm which regresses spontaneously in adult dogs but metastasizes and kills puppies transplanted with the neoplasm at a very young age. Immunofluorescence studies showed that 30 +/- 14% of cells from steady-state and 22 +/- 7% of cells from regressing tumors had membrane-bound antibodies which could be eluted out with warm washes at 24 degrees C, whereas the cells from progressor tumors had very little such antibody (6 +/- 6%). Time-course kinetics of anti-CTVS antibodies in the serum of tumor-bearing dogs did not correlate well with tumor volume, however, the presence of such antibodies in adult dogs (47 +/- 13%) but absence (0%) in the puppies with tumor metastasis suggested the importance of antibodies in resistance to metastasis.
Fenton
M A
MA
Department of Pathobiology, University of Connecticut, Storrs.
Yang
T J
TJ
D000818:Animals; D000912:Antibodies, Neoplasm / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology; D004285:Dogs; D007106:Immune Sera; D007113:Immunity, Innate; D007519:Isoantigens / Q000276:immunology; D009362:Neoplasm Metastasis / Q000276:immunology; D009368:Neoplasm Transplantation; D012075:Remission, Spontaneous; D012513:Sarcoma, Experimental / Q000276:immunology* / Q000473:pathology
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D007106:Immune Sera; D007519:Isoantigens