Depletion of trace elements and acute ocular toxicity induced by desferrioxamine in patients with thalassaemia.
High doses of intravenous desferrioxamine infused over a short period of time induce a large faecal and urinary iron excretion but also produce retinal abnormalities that are characterised by decreased amplitude on electroretinography and defective dark adaptation. This regimen also results in high faecal iron, zinc, and copper excretion, and reduced granulocyte zinc concentrations and alkaline phosphatase activity. The retinal abnormalities may be related to the zinc and copper deficiency and/or iron depletion 'per se' which interferes negatively with critical iron dependent enzymes.
De Virgiliis
S
S
Istituto di Clinica e Biologia dell Età Evolutiva, Università Studi Cagliari, Sardinia, Italy.
Congia
M
M
Turco
M P
MP
Frau
F
F
Dessi
C
C
Argiolu
F
F
Sorcinelli
R
R
Sitzia
A
A
Cao
A
A
D000293:Adolescent; D002648:Child; D003300:Copper / Q000172:deficiency* / Q000378:metabolism; D003676:Deferoxamine / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D004596:Electroretinography; D006801:Humans; D007262:Infusions, Intravenous; D012164:Retinal Diseases / Q000139:chemically induced*; D013789:Thalassemia / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors; D015032:Zinc / Q000172:deficiency* / Q000378:metabolism
D003300:Copper; D003676:Deferoxamine; D015032:Zinc