A long-term double-blind controlled study on the effect of azathioprine in the treatment of multiple sclerosis.
The results are reported of a small double-blind controlled trial on the effect of azathioprine in multiple sclerosis. Although a trend in favour of the treated group, as regards the effect on the disability, was found, it did not reach statistical significant levels. No influence was found on the relapse rate. The influence of side-effects, which were found in the treated group in a higher percentage than in the placebo group, on the results is discussed.
Minderhoud
J M
JM
Department of Neurology, University Hospital Groningen, the Netherlands.
Prange
A J
AJ
Luyckx
G J
GJ
D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy*
D001379:Azathioprine