The anti-hypertensive effect of potassium loading in experimental hypertension: a comparison of sheep with other species.
The anti-hypertensive effect of potassium (K) loading in human essential hypertension and several types of experimental hypertension is well established. However, the mechanism of the anti-hypertensive effect is not understood. The natriuretic effect of a high K intake has lead many to conclude that the blood pressure lowering effect of K may be mediated through enhanced sodium (Na) excretion leading to negative Na status. Review of the literature suggests that the anti-hypertensive effect of K loading, at least in sheep, can not be explained simply by changes in Na excretion.
Mills
E H
EH
Howard Florey Institute of Experimental Physiology and Medicine, Victoria, Australia.
Coghlan
J P
JP
Denton
D A
DA
Spence
C D
CD
Whitworth
J A
JA
Scoggins
B A
BA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects / Q000503:physiopathology; D004285:Dogs; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D011188:Potassium / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D012084:Renin-Angiotensin System / Q000187:drug effects; D012756:Sheep; D012964:Sodium / Q000097:blood; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology; D014655:Vascular Resistance / Q000187:drug effects
D012964:Sodium; D011188:Potassium