Deleterious effects of anabolic steroids on serum lipoproteins, blood pressure, and liver function in amateur body builders.
The effects of self-administered anabolic steroids (AS) on lipoproteins, liver function, and blood pressure were studied in male amateur body builders. Twenty body builders were studied at the end of a course of AS (group 1) and 42 body builders were studied after discontinuation of the AS for a mean of 5 months (group 2). Sixteen body builders were studied after discontinuation of AS for at least 2 months and at the end of a 9-week course of AS (group 3). A group of 13 body builders who never used AS served as a control group. Both groups 1 and 2 showed higher levels of transaminas and a higher systolic blood pressure than the controls (P less than 0.05). Group 3 showed an increase of the transaminases an a slight but significant increase of systolic blood pressure (+3 mm Hg) and heart rate (+7 bts/min) after one course of AS (P less than 0.05). Group 1 showed a considerably lower high-density lipoprotein cholesterol (HDLC) (P less than 0.001), a higher low-density lipoprotein cholesterol (LDLC) (P less than 0.05), and a lower apoprotein A-l/B ratio (Apo A-l/ApoB) (P less than 0.001) than the controls and group 2. The ratio of LDLC/HDLC in group 1 was fourfold higher than in the controls (P less than 0.01). In group 3 HDLC decreased from 1.18 +/- 0.05 to 0.60 +/- 0.08 mmol/l (P less than 0.001) and LDLC increased from 3.97 +/- 0.39 to 5.74 +/- 0.71 mmol/l (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Lenders
J W
JW
Department of Medicine, St. Radboud Hospital, University of Nijmegen, The Netherlands.
Demacker
P N
PN
Vos
J A
JA
Jansen
P L
PL
Hoitsma
A J
AJ
van 't Laar
A
A
Thien
T
T
D000328:Adult; D045930:Anabolic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001663:Bilirubin / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects*; D004300:Doping in Sports; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000187:drug effects*; D008297:Male; D012646:Self Administration; D013177:Sports; D000637:Transaminases / Q000097:blood; D014891:Weight Lifting
D045930:Anabolic Agents; D008074:Lipoproteins; D000637:Transaminases; D001663:Bilirubin