title: Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.
abstract: Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate. The clinical, biochemical, and pathological picture was similar to Reye's syndrome. Calcium hopantenate is a pantothenic acid antagonist. The serum levels of calcium hopantenate were high in coma, and that of pantothenic acid examined in one patient was lowered. Evidence obtained indicated that the Reye-like syndrome might be caused by calcium hopantenate possibly due to the induction of pantothenic acid deficiency.
authors: Department of Neurology, Kyushukoseinenkin Hospital, Kitakyushu, Japan.
authors: S
authors: S
authors: Noda
authors: H
authors: H
authors: Umezaki
authors: K
authors: K
authors: Yamamoto
authors: T
authors: T
authors: Araki
authors: T
authors: T
authors: Murakami
authors: N
authors: N
authors: Ishii
mesh_terms: D000368:Aged; D001706:Biopsy; D003704:Dementia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008854:Microscopy, Electron; D010205:Pantothenic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D012202:Reye Syndrome / Q000139:chemically induced* / Q000473:pathology; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid