Electron microscopical studies on rat intestine after long-term treatment with sennosides.
After gastric administration of daily 100 mg sennosides/kg body weight, no morphological differences could be found between the colon of treated rats and the controls. In particular, no damage to the intramural nerve tissue could be seen under the electron microscope.
Rudolph
R L
RL
Institut für Veterinär-Pathologie, Freie Universität, Berlin, BRD.
Mengs
U
U
D000818:Animals; D000880:Anthraquinones / Q000633:toxicity*; D002400:Cathartics / Q000633:toxicity; D003106:Colon / Q000187:drug effects* / Q000294:innervation / Q000648:ultrastructure; D005724:Ganglia / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D012676:Senna Extract; D000081226:Sennosides; D013997:Time Factors
D000880:Anthraquinones; D002400:Cathartics; D000081226:Sennosides; D012676:Senna Extract