title: Vitamin A hepatotoxicity in multiple family members.
abstract: Three of five family members experienced symptoms and biochemical evidence of hepatitis that could not be explained on the basis of infectious, metabolic or immunologic disorders of the liver. A history of prolonged ingestion of moderate amounts of vitamin A (20,000 to 45,000 IU per day for 7 to 10 years) was obtained in each of the three family members and was absent in the remaining two unaffected individuals. A liver biopsy performed in one family member confirmed the diagnosis of vitamin A toxicity. This report emphasizes the finding that even moderate amounts of vitamin A, when ingested over a prolonged period of time, can cause significant hepatocellular injury.
authors: Department of Medicine, University of Calgary, Alberta, Canada.
authors: G Y
authors: GY
authors: Minuk
authors: J K
authors: JK
authors: Kelly
authors: W S
authors: WS
authors: Hwang
mesh_terms: D000328:Adult; D001168:Arthritis / Q000188:drug therapy / Q000517:prevention & control; D005260:Female; D006801:Humans; D006986:Hypervitaminosis A / Q000150:complications*; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014801:Vitamin A / Q000627:therapeutic use
chemical_list: D014801:Vitamin A