title: 16q21 is critical for 16q deletion syndrome.
abstract: A 1-year-old girl with an interstitial deletion of the long arm of chromosome 16 is reported. She was characterized by a distinct craniofacial dysmorphism, meningoencephalocele, mild hydrocephalus, short neck, broad great toes and abnormally positioned toes. High resolution GTG and RBG banding analyses revealed a karyotype: 46,XX,del(16) (q13q22) de novo. An analysis of the smallest region of overlap revealed that the critical band region for 16q deletion syndrome is 16q21.
authors: Department of Pediatrics, School of Medicine, University of the Ryukyus, Okinawa, Japan.
authors: K
authors: K
authors: Naritomi
authors: N
authors: N
authors: Shiroma
authors: Y
authors: Y
authors: Izumikawa
authors: K
authors: K
authors: Sameshima
authors: S
authors: S
authors: Ohdo
authors: K
authors: K
authors: Hirayama
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics*; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007223:Infant; D013577:Syndrome