[Induction of immunologic deficiency by benzene and its correction by administration of anabol].
Cellular immunity and activity of enzymes of xenobiotic metabolism have been investigated. It has been shown that administration of benzene induces a stable immune deficiency syndrome characterized by a decrease in the quantity if antibody-forming cells, T-killers and T-suppressors. The activity of enzymes (cytochrome P-450 and cytochrome C reductase) was also inhibited. It has been shown that anabol can stimulate the parameters of cellular immunity and enzyme activity. Benzene intoxication was demonstrated to be a model of immune deficiency syndrome similar to the clinical pattern. Anabol was shown to be an effective immunomodulator.
Karaulov
A V
AV
Ogarkov
V I
VI
Khromenkov
Iu I
IuI
Frash
V N
VN
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001554:Benzene / Q000506:poisoning*; D001688:Biological Products / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced* / Q000188:drug therapy; D007778:Lactobacillus; D051379:Mice; D008810:Mice, Inbred C57BL
D000276:Adjuvants, Immunologic; D001688:Biological Products; C055313:anabol; D001554:Benzene
Induktsiia immunodefitsita benzolom i ego korrektsiia vvedeniem anabola.