Stimulatory action of ascorbic acid on methyl mercury-induced lipid peroxidation in rabbit kidney cortex slices.
Effects of ascorbic acid on the methylmercuric chloride (MMC)-induced lipid peroxidation and the accumulation of MMC in rabbit kidney cortical slices were studied. Ascorbic acid had a powerful stimulatory effect on the MMC-induced lipid peroxidation, while it produced only a small increase in the MMC accumulation. This results suggests that ascorbic acid increases slightly the accumulation of MMC, but that the stimulatory action of ascorbic acid on the MMC-induced lipid peroxidation cannot be explained simply by the increase in the MMC accumulation.
Fujimoto
Y
Y
Department of Hygienic Chemistry, Osaka University of Pharmaceutical Sciences, Japan.
Sakamoto
N
N
Kitaura
H
H
Ikeda
E
E
Fujita
T
T
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008767:Methylmercury Compounds / Q000633:toxicity*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits; D013268:Stimulation, Chemical; D013858:Thiobarbiturates / Q000494:pharmacology
D008054:Lipid Peroxides; D008767:Methylmercury Compounds; D013858:Thiobarbiturates; D001205:Ascorbic Acid