Effects of quinolones on mitogen-stimulated human mononuclear leucocytes.
The effects of several quinolone compounds on mitogen-stimulation of normal human mononuclear leucocytes were studied. In these experiments, mononuclear leucocytes were obtained from heparinized whole blood of healthy young adult donors by Ficoll-hypaque sedimentation. The cells were cultured in the presence of both mitogen and various concentrations of the quinolone compounds. Control cultures (without the addition of the quinolones) were examined concurrently. Our data suggests that the quinolones tested, with the exception of rosoxacin (acrosoxacin) at a concentration of 2.5 mg/l, neither impair nor stimulate activation of lymphocytes by the mitogen phytohaemagglutinin (PHA) when used at the concentrations obtained during therapy.
Manzella
J P
JP
Department of Medicine, York Hospital, PA 17405.
Clark
J K
JK
D042462:4-Quinolones; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects; D002939:Ciprofloxacin / Q000009:adverse effects / Q000031:analogs & derivatives; D024841:Fluoroquinolones; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects*; D009643:Norfloxacin / Q000009:adverse effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D011804:Quinolines / Q000009:adverse effects*; D015363:Quinolones
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D010835:Phytohemagglutinins; D011804:Quinolines; D015363:Quinolones; C021083:rosoxacin; D002939:Ciprofloxacin; C040691:amifloxacin; D009643:Norfloxacin