Prognostic relevance of serum-markers in relation to histopathology, stage and initial symptoms in advanced low-grade non-Hodgkin lymphomas.
The prognostic relevance of 4 different serum markers (deoxythymidine kinase = S-TK, lactic dehydrogenase = S-LDH, S-Haptoglobin and S-Orosomucoid) in relation to histopathology according to the Kiel classification, stage and presence or absence of initial symptoms were investigated in 168 consecutive cases of low-grade non-Hodgkin lymphomas (NHL). All serum markers, as well as the other three parameters, gave prognostic information. Univariate analysis yielded a high predictive value (p less than 0.0002) for both S-TK and S-LDH. The best information regarding the probability of survival was, however, obtained from the presence or absence of symptoms from lymphoma manifestations other than those caused by a strictly local tumor mass. Since S-TK and S-LDH correlated well with each other, only the better of them, S-TK, gave information additional to initial symptoms in a multivariate test.
Martinsson
U
U
Department of Oncology, University of Uppsala, Akademiska sjukhuset, Sweden.
Glimelius
B
B
Hagberg
H
H
Sundström
C
C
D000368:Aged; D014408:Biomarkers, Tumor; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D009961:Orosomucoid / Q000032:analysis; D011379:Prognosis; D013223:Statistics as Topic; D013937:Thymidine Kinase / Q000032:analysis; D013997:Time Factors
D014408:Biomarkers, Tumor; D006242:Haptoglobins; D009961:Orosomucoid; D007770:L-Lactate Dehydrogenase; D013937:Thymidine Kinase