Compromised wound repair caused by perioperative use of ibuprofen.
Nonsteroidal anti-inflammatory drugs have been shown to inhibit inflammation, an integral part of the wound-healing process. Compromised wound repair has been demonstrated in laboratory animals administered high-dose nonsteroidal anti-inflammatory drugs, a phenomenon we speculate could occur in humans undergoing surgery. We report a dramatic case of impaired wound healing in a patient ingesting high-dose perioperative ibuprofen, a nonsteroidal anti-inflammatory drug.
Proper
S A
SA
Department of Internal Medicine, University of South Florida, College of Medicine, Tampa 33612.
Fenske
N A
NA
Burnett
S M
SM
Luria
L W
LW
D002062:Bursitis / Q000188:drug therapy / Q000209:etiology; D002281:Carcinoma, Basosquamous / Q000150:complications / Q000601:surgery; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012878:Skin Neoplasms / Q000150:complications / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects*
D007052:Ibuprofen