Hormonal enhancement of neurogenesis and its relationship to the duration of olfactory memory.
On mating with a stud male, virgin female mice from an olfactory memory to this male which is essential to their reproductive success. Failure to form this memory results in the stud male being treated as strange, and hence, his pheromones block pregnancy. This study investigates the duration of the olfactory memory, and the factors which determine this. The results show that a single prolonged exposure to the male during mating forms a life-long olfactory memory trace unless pregnancy ensues. In the event of pregnancy the olfactory memory fades significantly faster, an effect which can be replicated by implants of oestradiol in non-pregnant females. Anatomical studies indicate that neurogenesis of the vomeronasal receptors is enhanced during pregnancy, an event which we interpret as being important for the duration of this olfactory memory.
Kaba
H
H
Department of Anatomy, University of Cambridge, U.K.
Rosser
A E
AE
Keverne
E B
EB
D000818:Animals; D005260:Female; D008297:Male; D008568:Memory / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009300:Nasal Septum / Q000294:innervation*; D009831:Olfactory Mucosa / Q000294:innervation*; D010675:Pheromones / Q000502:physiology*; D012724:Sex Attractants / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000502:physiology; D012903:Smell / Q000502:physiology*
D010675:Pheromones; D012724:Sex Attractants