[Interrelation of the antihypoxic effect of indolinones with their structural, physicochemical and pharmacological characteristics].
The effect of different indolinones in hypobaric and other forms of hypoxia was studied. The antihypoxic effect was found to be provided by the presence of the structural indolin-2-one fragment. The relationship between the antihypoxic activity and various structural, physicochemical and pharmacological properties of the compounds of this series was established. Realization of the antihypoxic activity of indolinones at the functional and metabolic levels was shown to be possible.
Mazhilis
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Garalene
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D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000401:mortality; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004353:Drug Evaluation, Preclinical; D005260:Female; D000860:Hypoxia / Q000188:drug therapy* / Q000401:mortality; D007211:Indoles / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D008297:Male; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship
D007211:Indoles
O vzaimosviazi protivogipoksicheskogo éffekta indolinonov s ikh strukturnymi, fiziko-khimicheskimi i farmakologicheskimi osobennostiami.