title: Regional changes in the cellular level of adenine nucleotides in ischemic rat brain subjected to single embolization.
abstract: Regional changes in adenine nucleotides in the rat brain were studied after 1 h of ischemia produced by the embolization method. The animals were divided into three groups according to neurological symptoms: sham-operation group, group A (hemiparesis only), and group B (hemiparesis with unconsciousness). Marked ATP depletion was detected in the hippocampus on the embolized side and extended to the other regions on the same side in group B. The results suggest that this damage in regional energy metabolism arises from regional reduction in blood flow and/or tissue vulnerability. ATP levels in the hypothalamus, hippocampus, and striatum on the opposite side of embolization decreased markedly in group B, and may be caused by extension of brain edema or diaschisis.
authors: Department of Neurosurgery, Hiroshima University School of Medicine, Japan.
authors: K
authors: K
authors: Yamada
authors: T
authors: T
authors: Uozumi
authors: T
authors: T
authors: Kawasaki
authors: K
authors: K
authors: Yamada
authors: T
authors: T
authors: Sogabe
authors: K
authors: K
authors: Ohta
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000378:metabolism; D004734:Energy Metabolism; D006150:Guanine Nucleotides / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D002542:Intracranial Embolism and Thrombosis / Q000150:complications; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000378:metabolism*; D008297:Male; D008636:Mesencephalon / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000227:Adenine Nucleotides; D006150:Guanine Nucleotides; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate