Results of transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma in a series of 214 patients.
Of 214 patients with acromegaly who underwent transsphenoidal microsurgical resection of a pituitary adenoma, 54% had growth hormone (GH) levels below 5 ng/ml and 74% had levels less than 10 ng/ml immediately after surgery. Among the 174 patients who could be contacted for long-term follow-up review (average duration 76 months), most recent GH determinations were available for 165. Of these 165 patients, 131 (79.4%) have a GH level less than 5 ng/ml and 153 (92.7%) have a level below 10 ng/ml; these represent 75.3% and 87.9%, respectively, of the total 174 patients reviewed. Fifty-two patients received postoperative radiation therapy. Nine patients underwent reoperation. There were five cases of tumor recurrence following an apparent surgical cure (4.3%), nine new instances of anterior pituitary hypofunction (5%), and five failures of multimodality therapy (2.3%). There were no perioperative deaths, five cases of cerebrospinal fluid leak requiring surgical repair (2.2%), and four cases of postoperative meningitis (1.8%). Permanent diabetes insipidus did not occur. Two of 52 patients who were irradiated postoperatively had severe complications; 23 (54.8%) of 42 patients who were available for follow-up evaluation had developed panhypopituitarism; and eight (19%) of 42 had normal pituitary function an average of 44 months postirradiation.
Ross
D A
DA
Department of Neurological Surgery, School of Medicine, University of California, San Francisco.
Wilson
C B
CB
D000172:Acromegaly / Q000209:etiology; D000236:Adenoma / Q000150:complications / Q000378:metabolism / Q000532:radiotherapy / Q000601:surgery*; D001971:Bromocriptine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004700:Endocrine System Diseases / Q000209:etiology; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008866:Microsurgery; D010911:Pituitary Neoplasms / Q000150:complications / Q000378:metabolism / Q000532:radiotherapy / Q000601:surgery*; D011183:Postoperative Complications; D012008:Recurrence; D013100:Sphenoid Bone / Q000601:surgery*
D001971:Bromocriptine; D013006:Growth Hormone