Relation of left ventricular function and Na,K-pump concentration in suspected idiopathic dilated cardiomyopathy.
The possible relation between Na-K-pump concentration and left ventricular (LV) function was studied in 24 patients with suspected idiopathic dilated cardiomyopathy. This was done by measurement of 3H-ouabain binding to biopsies obtained during left-sided heart catheterization. In all patients light microscopy of biopsies was compatilel with dilated cardiomyopathy. Nineteen patients had impaired LV function as defined by NYHA/WHO and a Na,K-pump concentration of 331 +/- 19 pmol/g wet weight, whereas 5 patients had normal LV function and a Na,K-pump concentration of 559 +/- 62 pmol/g wet weight (p less than 0.001). The correlation between Na,K-pump concentration and ejection fraction was highly significant n = 24, r = 0.81, p less than 0.001). There was no correlation between volume fraction of collagen tissue and Na,K-pump concentration in the biopsies (n = 24, r = -0.08, p less than 0.80), indicating that the decrease in Na,K-pump concentration with dilated cardiomyopathy is not the simple outcome of increased fibrosis in the myocardium. The results indicate that the decrease in Na,K-pump concentration may be of importance for myocardial dysfunction and suggest a simple biochemical assessment of dilated cardiomyopathy by measurement of 3H-ouabain binding.
Nørgaard
A
A
Department of Cardiology, Aarhus Municipal Hospital, Denmark.
Bagger
J P
JP
Bjerregaard
P
P
Baandrup
U
U
Kjeldsen
K
K
Thomsen
P E
PE
D000328:Adult; D001693:Biological Transport, Active; D001706:Biopsy; D006328:Cardiac Catheterization; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D010042:Ouabain / Q000032:analysis; D011188:Potassium / Q000378:metabolism*; D011869:Radioligand Assay; D012964:Sodium / Q000378:metabolism*
D010042:Ouabain; D012964:Sodium; D011188:Potassium