[Lipid peroxidation and the mechanisms of hepatocyte damage and protection in chronic hepatitis and cirrhosis].
A study was made of the indices of lipid peroxidation (LPO)--conjugated dienes (CD) and diene ketones (D), cyclic nucleotides (CN)--cAMP and cGMP, prostaglandins (PG) E and F2 alpha in biopsy tissue of the liver in 55 patients with chronic hepatitis (CH) and liver cirrhosis (LC). LPO was determined by spectrophotometry, CH and LC--by a radioimmunoassay. In patients with CPH and CAH the indices of LPO and cGMP were normal, cAMP, PG and PGE/PGF2 alpha were raised. In a severe fast progressive liver lesion disorder of coordination activity of the cell membranous systems was characterized by a high LPO activity, a decrease in cAMP and relative deficit of liver PG.
Iagoda
A V
AV
Smirnova
O V
OV
Mosin
V I
VI
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006521:Hepatitis, Chronic / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D008054:Lipid Peroxides / Q000032:analysis / Q000378:metabolism*; D008099:Liver / Q000032:analysis / Q000378:metabolism* / Q000473:pathology; D008103:Liver Cirrhosis / Q000209:etiology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009712:Nucleotides, Cyclic / Q000032:analysis / Q000378:metabolism; D010084:Oxidation-Reduction; D011453:Prostaglandins / Q000032:analysis / Q000096:biosynthesis
D008054:Lipid Peroxides; D009712:Nucleotides, Cyclic; D011453:Prostaglandins
Perekisnoe okislenie lipidov i nekotorye mekhanizmy povrezhdeniia i zashchity gepatitov pri khronicheskom gepatite i tsirroze.