title: [Functional activity of the adrenal glands and the hormone-protein interactions in patients with hypertension with a complicated course].
abstract: Patients with essential hypertension and hypertension complicated by coronary heart disease showed adrenal glucocorticoid activation along with reduced transcortin binding capacity (TBC). The addition of circulatory insufficiency (stage I and IIB) resulted in a decrease of the functional adrenal reserve and further diminution of TBC due to a reduction of protein binding sites concentration, and sometimes (stage IIB) also a decrease in the protein affinity of steroids. A correlation between TBC and plasma protein level was found. The absence of adrenal functional response to an abrupt drop in TBC is interpreted as a complete failure of the adaptation systems.
authors: L I
authors: LI
authors: Nadol'nik
authors: E A
authors: EA
authors: Galitskiĭ
authors: V G
authors: VG
authors: Beluga
authors: N D
authors: ND
authors: Butkevich
authors: V P
authors: VP
authors: Vodoevich
mesh_terms: D015062:11-Hydroxycorticosteroids / Q000378:metabolism*; D000302:Adrenal Cortex / Q000378:metabolism*; D000328:Adult; D003327:Coronary Disease / Q000150:complications / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged; D011485:Protein Binding; D014156:Transcortin / Q000378:metabolism*
chemical_list: D015062:11-Hydroxycorticosteroids; D014156:Transcortin
vernacular_title: Funktsional'naia aktivnost' nadpochechnikov i gormonobelkovye vzaimodeĭstviia u bol'nykh gipertonicheskoĭ bolezn'iu s oslozhnennym techeniem.