title: Protective immunity and eosinophilia in IgE-deficient SJA/9 mice infected with Nippostrongylus brasiliensis and Trichinella spiralis.
abstract: To elucidate the roles of IgE antibody in host responses to helminth infection, selective IgE-deficient SJA/9 mice were infected with the nematode parasites Nippostrongylus brasiliensis, which elicits remarkable potentiated IgE production, and Trichinella spiralis, which induces strong anti-Trichinella IgE antibody production in normal mice. The kinetics of blood eosinophilia, worm burden after primary infection, and resistance to secondary infection in SJA/9 mice were the same in both infections as those in congenic SJL/J mice used as an IgE-producing control. These results indicate that the host responses examined here operate under IgE-independent mechanisms.
authors: Department of Parasitology, Jikei University School of Medicine, Tokyo, Japan.
authors: N
authors: N
authors: Watanabe
authors: K
authors: K
authors: Katakura
authors: A
authors: A
authors: Kobayashi
authors: K
authors: K
authors: Okumura
authors: Z
authors: Z
authors: Ovary
mesh_terms: D000818:Animals; D004406:Dysgammaglobulinemia / Q000276:immunology*; D004802:Eosinophilia / Q000276:immunology*; D007073:Immunoglobulin E / Q000032:analysis / Q000172:deficiency*; D051379:Mice; D008817:Mice, Mutant Strains; D009349:Nematode Infections / Q000276:immunology*; D009559:Nippostrongylus / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D012016:Reference Values; D014235:Trichinellosis / Q000276:immunology*
chemical_list: D007073:Immunoglobulin E