Studies on yellow fever vaccine. III--Dose response in volunteers.
Standard and stabilized yellow fever (YF) vaccines were compared on the basis of the serological responses of human volunteers to varying doses of vaccine measured as pfu or LD50. The addition of stabilizer substances to bulk vaccine did not affect the immunogenicity and stabilized vaccine gave a consistently good performance. The vaccine fulfilled WHO recommendations in inducing 100% serological conversion in volunteers given about 200 pfu or 600 LD50.
Lopes Ode
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S
Fundação Oswaldo Cruz, Bio-Manguinhos, Rio de Janeiro, Brazil.
Guimarães
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SS
de Carvalho
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R
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D008297:Male; D008875:Middle Aged; D010948:Viral Plaque Assay; D014765:Viral Vaccines / Q000592:standards*; D015005:Yellow fever virus / Q000276:immunology*
D000914:Antibodies, Viral; D014765:Viral Vaccines