Identification of metabolites of tiropramide in human urine.
The metabolites of tiropramide were extracted from the urine of healthy volunteers given tiropramide hydrochloride orally. Eight metabolites of tiropramide were found by gas chromatography/mass spectrometry. Three were identified on the basis of their mass spectra, retention times and comparison with synthetic standards. For the others a probable structure is proposed on the basis of their mass spectra.
Arigoni
R
R
Rotta Research Laboratorium S.p.A., Milano, Italy.
Chistè
R
R
Makovec
F
F
Setnikar
I
I
Benfenati
E
E
Fanelli
R
R
D000328:Adult; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000652:urine
D014443:Tyrosine; C031173:tiropramide