A specific translocation, t(12;14)(q14-15;q23-24), characterizes a subgroup of uterine leiomyomas.
We have cytogenetically investigated short-term cultures initiated from 34 uterine leiomyomas, all of which were histologically completely benign. Clonal chromosome abnormalities were detected in five cases, a normal female complement in 22, whereas, in the remaining seven tumors no karyotype could be established. Apparently identical reciprocal translocations, t(12;14)(q14-15;q23-24), were found as the sole abnormality in four tumors. The fifth abnormal case contained a t(2;14)(p11;p11). We conclude that chromosome aberrations may be found in myomas of the uterus, and that t(12;14)(q14-15;q23-24) characterizes a subset of these tumors.
Heim
S
S
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Nilbert
M
M
Vanni
R
R
Floderus
U M
UM
Mandahl
N
N
Liedgren
S
S
Lecca
U
U
Mitelman
F
F
D002871:Chromosome Banding; D002881:Chromosomes, Human, Pair 12; D002883:Chromosomes, Human, Pair 14; D005260:Female; D006801:Humans; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics*; D014178:Translocation, Genetic; D014594:Uterine Neoplasms / Q000235:genetics*