Trace analysis of airborne 1,6-hexamethylenediisocyanate and the related aminoisocyanate and diamine by glass capillary gas chromatography.
A capillary gas chromatographic method was developed for the analysis of complex air mixtures of 1,6-hexamethylenediisocyanate, 1,6-hexamethyleneaminoisocyanate and 1,6-hexamethylenediamine. The method is based on derivatization in the sampling step of the reactive isocyanate groups to corresponding urethane groups by the alkaline ethanolic solvent and a subsequent derivatization of remaining amino groups to amide groups with heptafluorobutyric acid anhydride. The overall procedure, including sampling, gave a linear response at air concentrations of 3-300 micrograms/m3 for 1,6-hexamethylenediisocyanate with a precision of ca. 4% at 15 micrograms/m3 and a detection limit of ca. 0.2 microgram/m3 using nitrogen selective detection. In a field measurement of air concentrations in welding work on lacquered metal parts at a motor-car workshop, concentrations of 1,6-hexamethylenediisocyanate above 600 micrograms/m3 were found. Also 1,6-hexamethyleneaminoisocyanate and 1,6-hexamethylenediamine were found at concentrations of the order of 15% of the 1,6-hexamethylenediisocyanate concentration.
Skarping
G
G
Department of Occupational Medicine, University of Lund, Sweden.
Dalene
M
M
Mathiasson
L
L
D000393:Air Pollutants / Q000032:analysis*; D000395:Air Pollutants, Occupational / Q000032:analysis; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D002849:Chromatography, Gas / Q000379:methods; D003485:Cyanates / Q000032:analysis*; D003959:Diamines / Q000032:analysis*; D005410:Flame Ionization; D008401:Gas Chromatography-Mass Spectrometry; D017953:Isocyanates; D012997:Solvents
D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D003485:Cyanates; D003959:Diamines; D017953:Isocyanates; D012997:Solvents; C015262:1,6-hexamethylene diisocyanate; C055537:1,6-hexamethyleneaminoisocyanate; C007297:1,6-diaminohexane