title: Diabetes and low Ca-P diet have opposite effects on adult and fetal bone mineral metabolism.
abstract: The effect of diabetes on maternal bone mineral metabolism and fetal mineralization was studied in nonpregnant and pregnant BB rats fed two diets (0.85% calcium-0.7% phosphorus and 0.2% calcium-phosphorus). Non-pregnant female diabetic rats had normal total bone mineral content (BMC), despite decreased trabecular bone volume density (TBVD). Nondiabetic rats on the low calcium-phosphorus diet showed decreased TBVD, signs of increased bone turnover, and decreased BMC; plasma 1,25-dihydroxyvitamin D3 [1,25 (OH)2D3] was increased and urinary calcium excretion was decreased. A similar response was observed in diabetic rats with a further decrease in TBVD. Nondiabetic 21-day pregnant rats on high and low calcium-phosphorus diets had higher 1,25(OH)2D3 than nonpregnant rats (98 vs. 58 and 328 vs. 147 pg/ml, respectively). Maternal BMC did not change during pregnancy but was decreased by the low calcium-phosphorus diet; fetal mineral content was not influenced by the low calcium-phosphorus regime. No increase in 1,25(OH)2D3 was observed in pregnant diabetic rats (57 vs. 52 and 112 vs. 128 pg/ml in high and low calcium-phosphorus diet groups). Fetal mineralization was severely impaired in diabetes but was not further decreased by the low calcium-phosphorus diet. Thus nonpregnant diabetic rats respond normally to a low calcium-phosphorus diet, but pregnant diabetic rats do not show increased 1,25(OH)2D3 levels due to impairment of fetal mineralization.
authors: Department of Obstetrics and Gynecology, Katholieke Universiteit Leuven, Belgium.
authors: J
authors: J
authors: Verhaeghe
authors: R
authors: R
authors: Bouillon
authors: W
authors: W
authors: Lissens
authors: W J
authors: WJ
authors: Visser
authors: F A
authors: FA
authors: Van Assche
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism; D000818:Animals; D001842:Bone and Bones / Q000196:embryology / Q000378:metabolism*; D002118:Calcium; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000382:microbiology; D004032:Diet; D005260:Female; D005333:Fetus / Q000378:metabolism; D008903:Minerals / Q000378:metabolism; D010758:Phosphorus; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011913:Rats, Inbred BB
chemical_list: D008903:Minerals; D010758:Phosphorus; D002118:Calcium