Modification of total body fat in spontaneously hypertensive rats and Wistar-Kyoto rats by dietary calcium and sodium.
Studies have indicated that spontaneously hypertensive rats (SHRs) consuming diets high in calcium (Ca2+) and sodium (Na+) weigh less compared to SHRs consuming diets lower in Ca2+ and Na+ while consuming similar amounts of food. Based on calcium's known effects on lipid metabolism, it was important to determine if manipulations of dietary Ca2+ and Na+ would modify total body fat in the SHR. Fifteen SHRs and 17 Wistar Kyoto rats (WKY) were randomized at 4 weeks of age to three diets varying in Ca2+ and Na+: 2% Ca2+/1.0% Na+, 1% Ca2+/0.45% Na+, and 0.1% Ca2+/0.25% Na+. At 15 weeks of age, blood pressure, body weight, and body composition were determined. Significant differences in body weight, blood pressure, and total body fat were observed between diet groups in both strains. Dietary Ca2+ and Na+ induced favorable changes in total body fat content in both the SHR and WKY.
Metz
J A
JA
Division of Nephrology and Hypertension, Oregon Health Sciences University, Portland 97201.
Karanja
N
N
Torok
J
J
McCarron
D A
DA
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002136:Calcium, Dietary / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D012982:Sodium, Dietary / Q000494:pharmacology*
D002136:Calcium, Dietary; D012982:Sodium, Dietary