Complete prevention of acetylcholine induced coronary artery spasm with nifedipine.
A 63-year-old woman has been known to have angina pectoris due to coronary artery (CA) spasm. An intra-left CA infusion of acetylcholine (ACh) provoked spasms of the left CA and an anginal attack. After daily oral administration of nifedipine (NIF) for 2 weeks, intra-CA re-infusion study of ACh did not provoke any CA spasms. This is the first report to demonstrate the complete prevention of ACh-induced CA spasm with nifedipine.
Shimizu
K
K
First Department of Internal Medicine, Fukui Medical School.
Ogawa
K B
KB
Kato
T
T
Lee
J D
JD
Hara
A
A
Nakamura
T
T
D000109:Acetylcholine / Q000009:adverse effects*; D000787:Angina Pectoris / Q000209:etiology; D000792:Angiography; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*
D009543:Nifedipine; D000109:Acetylcholine