Lack of birth defects among offspring conceived during or after paternal exposure to dibromochloropropane (DBCP).
The present study describes birth defects and health status of offspring of men with dibromochloropropane (DBCP) induced testicular dysfunction. One case with a major anomaly (urinary bladder extrophy and epispadias) and 2 cases of minor birth defects were observed among the 34 children evaluated. This rate was similar and not significantly different (p = 0.80) from that observed in a control group of 51 children conceived during pre-exposure in the same families. The health status of all the children was unremarkable. It is concluded that paternal exposure to DBCP, severe enough to cause azoospermia or oligozoospermia, did not increase the rate of congenital malformations or of impaired health status of offspring conceived during or after exposure.
Potashnik
G
G
Division of Obstetrics and Gynecology, Soroka University Hospital, Beer Sheva/Israel.
Phillip
M
M
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006304:Health Status; D006801:Humans; D007223:Infant; D008297:Male; D009845:Oligospermia / Q000139:chemically induced; D011407:Propane / Q000009:adverse effects / Q000031:analogs & derivatives*; D013094:Spermatozoa / Q000187:drug effects*; D013733:Testicular Diseases / Q000139:chemically induced
C007318:1,2-dibromo-3-chloropropane; D011407:Propane