Effects of ethidium bromide and nalidixic acid pretreatment on the induction of chromatid aberrations by TEM and maleic hydrazide in Vicia faba main root meristems.
Pretreatment of Vicia faba main root meristems with ethidium bromide (EB) or nalidixic acid (NA) significantly reduced the yield of metaphases with chromatid aberrations induced by maleic hydrazide (MH), i.e., triggered clastogenic adaptation to MH. No such protection occurred when the alkylating agent triethylenemelamine (TEM) was used for challenge treatment. The differential response of pretreated cells to MH on the one hand (protection) and to TEM (no protection) on the other supports the conclusion that clastogenic adaptation is due to different inducible (repair?) functions, which eventually exert protection against clastogenic impacts.
Michaelis
A
A
Zentralinstitut für Genetic und Kulturpflanzenforschung der AdW der D.D.R., Gatersleben.
Rieger
R
R
Nicoloff
H
H
D002842:Chromatids / Q000187:drug effects; D002869:Chromosome Aberrations; D004260:DNA Repair; D004347:Drug Interactions; D004996:Ethidium / Q000494:pharmacology*; D007887:Fabaceae / Q000187:drug effects / Q000235:genetics*; D008300:Maleic Hydrazide / Q000494:pharmacology*; D009268:Nalidixic Acid / Q000494:pharmacology*; D010946:Plants, Medicinal; D011724:Pyridazines / Q000494:pharmacology*; D014265:Triethylenemelamine / Q000494:pharmacology*
D011724:Pyridazines; D009268:Nalidixic Acid; D004996:Ethidium; D014265:Triethylenemelamine; D008300:Maleic Hydrazide