title: The influence of oxygen tension on membrane potential and tone of canine carotid artery smooth muscle.
abstract: In vascular smooth muscle of canine carotid artery segments the decrease in oxygen tension from approximately 550 mmHg to approximately 30 mmHg leads to a dose-dependent hyperpolarization and relaxation of the vessel strip. At PO2 values below approximately 15-20 mmHg depolarization and subsequent contraction were found. All changes of the parameters investigated were reversible. Indomethacin (10(-5) M) had no significant effect on the hypoxia-dependent potential and tension changes. The hyperpolarized part of the activation curve was obtained by plotting tension versus membrane potential values.
authors: Institute of Physiology I, University of Bonn, Germany.
authors: J
authors: J
authors: Grote
authors: G
authors: G
authors: Siegel
authors: K
authors: K
authors: Zimmer
authors: A
authors: A
authors: Adler
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects / Q000502:physiology*; D004285:Dogs; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008564:Membrane Potentials; D009129:Muscle Tonus; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure
chemical_list: D010100:Oxygen; D007213:Indomethacin