Effect of metoclopramide, bethanechol and the cholecystokinin receptor antagonist, L-364,718, on gastric emptying in the rat.
The prokinetic effects of metoclopramide, bethanechol and L-364,718 on a semisolid meal and solid pellet gastric emptying were evaluated and compared. Each compound increased the rate of meal emptying as measured 90 min post-dose. L-364,718, a non-peptide CCK antagonist, was the most potent of these three agents with statistically significant activity observed at 0.03, 0.1 and 0.3 mg/kg p.o. Only metoclopramide significantly enhanced pellet emptying in a dose-dependent manner (3-30 mg/kg p.o.). The effects of each test agent and the potential physiologic role of cholecystokinin in regulating gastric emptying are discussed.
Decktor
D L
DL
Rorer Central Research, Horsham, PA 19044.
Pendleton
R G
RG
Elnitsky
A T
AT
Jenkins
A M
AM
McDowell
A P
AP
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D001626:Bethanechol Compounds / Q000494:pharmacology*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D020109:Devazepide; D005746:Gastric Emptying / Q000187:drug effects*; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011949:Receptors, Cholecystokinin / Q000187:drug effects / Q000378:metabolism*
D001570:Benzodiazepinones; D001626:Bethanechol Compounds; D011949:Receptors, Cholecystokinin; D002766:Cholecystokinin; D020109:Devazepide; D008787:Metoclopramide