Novel antihypertensives targeted at dopamine beta-monooxygenase: turnover-dependent cofactor depletion by phenyl aminoethyl selenide.
May
S W
SW
School of Chemistry, Georgia Institute of Technology, Atlanta.
Wimalasena
K
K
Herman
H H
HH
Fowler
L C
LC
Ciccarello
M C
MC
Pollock
S H
SH
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002837:Chromaffin Granules / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*; D005021:Ethylamines / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D016566:Organoselenium Compounds; D051381:Rats; D011918:Rats, Inbred SHR
D000959:Antihypertensive Agents; D005021:Ethylamines; D016566:Organoselenium Compounds; C056035:phenyl-2-aminoethylselenide; D004299:Dopamine beta-Hydroxylase; D001205:Ascorbic Acid