Structure of an escape mutant of glycoprotein N2 neuraminidase of influenza virus A/Tokyo/3/67 at 3 A.
The three-dimensional structure of the membrane glycoprotein neuraminidase of an escape mutant of the influenza virus strain A/Tokyo/3/67 has been determined to 3 A (1 A = 0.1 nm) resolution by X-ray diffraction. The mutant virus, selected by growing the virus in the presence of a monoclonal antibody to the neuraminidase, is shown to have undergone a single amino acid change of lysine to glutamic acid at residue 368. The three-dimensional structure of the neuraminidase is identical with that reported for A/Tokyo/3/67, except for a purely local adjustment of the structure at position 368.
Varghese
J N
JN
C.S.I.R.O. Division of Protein Chemistry, Parkville, Victoria, Australia.
Webster
R G
RG
Laver
W G
WG
Colman
P M
PM
D000595:Amino Acid Sequence; D009980:Influenza A virus / Q000201:enzymology*; D008562:Membrane Glycoproteins; D009154:Mutation; D009439:Neuraminidase; D014763:Viral Matrix Proteins; D014961:X-Ray Diffraction
D008562:Membrane Glycoproteins; D014763:Viral Matrix Proteins; D009439:Neuraminidase