title: Ketamine-xylazine anesthesia in red-tailed hawks with antagonism by yohimbine.
abstract: Five red-tailed hawks (Buteo jamaicensis) were anesthetized at weekly intervals with intravenous ketamine hydrochloride (KET, 4.4 mg/kg) and xylazine hydrochloride (XYL, 2.2 mg/kg). Twenty min after anesthesia, yohimbine hydrochloride (YOH, 0.05, 0.10, 0.20 and 0.40 mg/kg) or a control was administered. All doses of YOH significantly reduced the head-up times (F = 20.84, df = 1,24, P less than 0.0001) and the standing times (F = 12.30, df = 1,24, P less than 0.0001), compared to the control group. The heart and respiratory rates following YOH (all doses) were significantly greater (P less than 0.01) than the anesthetized rates, but were comparable to the rates observed in restrained, unanesthetized hawks. Yohimbine did not appear to have any significant effect on body temperature. Based upon administration of 4.4 mg/kg KET and 2.2 mg/kg XYL, a dose of 0.10 mg/kg YOH was recommended to achieve antagonism without causing profound cardiovascular or respiratory changes.
authors: Raptor Research and Rehabilitation Program, University of Minnesota, St. Paul 55108.
authors: L A
authors: LA
authors: Degernes
authors: T J
authors: TJ
authors: Kreeger
authors: R
authors: R
authors: Mandsager
authors: P T
authors: PT
authors: Redig
mesh_terms: D000759:Adjuvants, Anesthesia; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous / Q000662:veterinary; D000818:Animals; D001717:Birds / Q000502:physiology*; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007649:Ketamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D012119:Respiration / Q000187:drug effects; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D015016:Yohimbine / Q000494:pharmacology*
chemical_list: D000759:Adjuvants, Anesthesia; D013843:Thiazines; D014991:Xylazine; D015016:Yohimbine; D007649:Ketamine