Stereoselective organic reactions: catalysts for carbonyl addition processes.
Important advances are being made in the development of stereoselective organic reactions. Some of the emerging research directions that hold forth great promise in this area deal with the development of chiral catalysts for these processes. This review attempts to unify one aspect of this field, the development of catalysts and catalyst models for the enantioselective addition of hydride and carbon nucleophiles to carbonyl substrates. Mechanistic constructs for the stereodifferentiating transition states are provided.
Evans
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Department of Chemistry, Harvard University, Cambridge, MA 02138.
D000447:Aldehydes; D002384:Catalysis; D055598:Chemical Phenomena; D002621:Chemistry; D007659:Ketones; D008670:Metals; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D000447:Aldehydes; D007659:Ketones; D008670:Metals