title: Remyelination by transplanted oligodendrocytes of a demyelinated lesion in the spinal cord of the adult shiverer mouse.
abstract: Fragments of normal newborn mouse central nervous system (CNS) were transplanted into the spinal cord of adult shiverer mice at distance of 1, 2 or 3 intervertebral spaces from a lysolecithin-induced demyelinating lesion. Remyelination by grafted oligodendrocytes was observed by electron microscopy (EM). This result showed the capability of grafted oligodendrocytes or precursor cells to migrate to a demyelinated lesion and to remyelinate naked axons in an adult host, even in presence of host spontaneous remyelination.
authors: INSERM U 134, Hôpital de la Salpétrière, Paris, France.
authors: O
authors: O
authors: Gout
authors: A
authors: A
authors: Gansmuller
authors: N
authors: N
authors: Baumann
authors: M
authors: M
authors: Gumpel
mesh_terms: D000818:Animals; D008244:Lysophosphatidylcholines; D051379:Mice; D008809:Mice, Inbred C3H; D008818:Mice, Neurologic Mutants / Q000502:physiology*; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000502:physiology* / Q000648:ultrastructure; D009416:Nerve Regeneration; D009457:Neuroglia / Q000637:transplantation*; D009830:Olfactory Bulb / Q000166:cytology; D009836:Oligodendroglia / Q000502:physiology / Q000637:transplantation* / Q000648:ultrastructure; D013116:Spinal Cord / Q000502:physiology* / Q000648:ultrastructure
chemical_list: D008244:Lysophosphatidylcholines