title: Failure to support the validity of the Fagerstrom Tolerance Questionnaire as a measure of physiological tolerance to nicotine.
abstract: We tested the validity of the Fagerström Tolerance Questionnaire as a measure of physiological tolerance to nicotine. Both clinical and laboratory studies found neither the total questionnaire score nor the individual questionnaire items were related to physiological tolerance as measured by heart rate, skin conductance, blood volume pulse, and skin temperature responses to smoking a cigarette. We hypothesize the questionnaire measures behavioral dependence or perceived dependence rather than physical dependence.
authors: Department of Psychology, University of Mississippi, University 38677.
authors: T W
authors: TW
authors: Lombardo
authors: J R
authors: JR
authors: Hughes
authors: J D
authors: JD
authors: Fross
mesh_terms: D000328:Adult; D001143:Arousal / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D004361:Drug Tolerance; D005260:Female; D005712:Galvanic Skin Response / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D012881:Skin Temperature / Q000187:drug effects; D012907:Smoking / Q000523:psychology*; D013375:Substance Withdrawal Syndrome / Q000523:psychology
chemical_list: D009538:Nicotine