[Constrictor reaction to transmural electric stimulation of the isolated femoral artery and its branches in chronic arterial hypotension].
Chronic regional arterial hypotension in the hind limbs of rats was produced by narrowing of the abdominal aorta. 14-19 days later the femoral artery and its main branches were isolated and perfused in vitro with oxygenated Krebs' solution. It was shown that constrictor responses to transmural electrical stimulation decreased 14-30 days after the constriction of the aorta, however, 90 days after the operation the responses were identical to those in the control. Guanethidine (1.10(-5) mol/l) decreased significantly the responses to stimulation in all the cases, while phentolamine (3.5.10(-5) mol/l) inhibited completely those reactions. The constriction of femoral arteries in response to noradrenaline infusion was the same in control and hypotensive vessels.
Terekova
R
R
Shenderov
S M
SM
Terek
I
I
D000818:Animals; D002908:Chronic Disease; D004558:Electric Stimulation; D005263:Femoral Artery / Q000187:drug effects / Q000294:innervation / Q000503:physiopathology*; D006145:Guanethidine / Q000494:pharmacology; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology*; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects
D009638:Norepinephrine; D010646:Phentolamine; D006145:Guanethidine
Konstriktornye reaktsii na transmural'nuiu élektricheskuiu stimuliatsiiu izolirovannykh bedrennykh arteriĭ s vetviami, dlitel'no nakhodivshikhsia v usloviiakh arterial'noĭ gipotenzii.