[Reactogenicity, toxicity and tolerance of reaferon in healthy volunteers].
In the clinical trial of reaferon, introduced intramuscularly and intravenously in different doses (2 X 10(6), 6 X 10(6) and 9 X 10(6) I. U. daily) for 3 days, various side effects were observed. Their intensity depended on the dose of the preparation and the route of administration. The most regular reaction was a rise in temperature, accompanied by slight weakness, headache, loss of appetite, slight dizziness, euphoria. All side effects were transient. No toxic or allergic reactions involving the organs and systems of the body were observed. Low doses of the preparation (2 X 10(6) I. U. daily) promoted an increase in the amount of lymphocytes in the peripheral blood, stimulated cellular immunity factors and contributed to the optimal functioning of the interferon systems. High doses (6 X 10(6) to 9 X 10(6) I. U. daily) had a pronounced immunosuppressing effect. On the whole, reaferon proved to be fairly tolerable.
Pokrovskiĭ
V I
VI
Zmyzgova
A V
AV
Murzabaeva
R T
RT
Fomina
T N
TN
Shalygina
N B
NB
D000293:Adolescent; D000328:Adult; D000917:Antibody Formation / Q000187:drug effects; D004306:Dose-Response Relationship, Immunologic; D004341:Drug Evaluation; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007370:Interferon Type I / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects; D013997:Time Factors
D007370:Interferon Type I; D011994:Recombinant Proteins
Izuchenie reaktogennosti, toksichnosti i perenosimosti reaferona na zdorovykh dobrovol'tsakh.