title: Glomeruli from ischemic rat kidneys produce increased amounts of platelet activating factor.
abstract: The production of Platelet Activating Factor (PAF-acether) by glomeruli isolated from rats subjected to a 60 min renal ischemia has been studied. PAF-acether has been purified by Sep-Pak columns and measured by its ability to release serotonin from previously loaded rabbit platelets. Glomeruli from ischemic kidneys had higher amounts of PAF-acether activity than glomeruli from sham operated rats. These data suggest a role for PAF-acether in the renal functional alterations induced by renal ischemia.
authors: Laboratory of Renal Physiopathology, Fundación Jiménez Diaz-CSIC, Madrid, Spain.
authors: A
authors: A
authors: López-Farré
authors: M
authors: M
authors: Torralbo
authors: J M
authors: JM
authors: López-Novoa
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D007511:Ischemia / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000378:metabolism*; D007700:Kinetics; D010972:Platelet Activating Factor / Q000096:biosynthesis*; D051381:Rats; D012016:Reference Values; D012079:Renal Circulation; D013929:Thromboxane B2 / Q000096:biosynthesis
chemical_list: D010972:Platelet Activating Factor; D013929:Thromboxane B2