MELAS syndrome: characteristic migrainous and epileptic features and maternal transmission.
Severe prolonged migrainous symptoms and prolonged partial status epilepticus are characteristic features of the MELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). Maternal transmission previously found in myoclonus epilepsy and ragged-red fibers (MERRF), another mitochondrial disease, is suggested in this disorder as well.
Montagna
P
P
Institute of Neurology, University of Bologna, Italy.
Gallassi
R
R
Medori
R
R
Govoni
E
E
Zeviani
M
M
Di Mauro
S
S
Lugaresi
E
E
Andermann
F
F
D000293:Adolescent; D001706:Biopsy; D004827:Epilepsy / Q000150:complications* / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications* / Q000235:genetics / Q000473:pathology; D008931:Mitochondria, Muscle / Q000648:ultrastructure; D009132:Muscles / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D012008:Recurrence; D013226:Status Epilepticus / Q000150:complications* / Q000235:genetics; D013577:Syndrome; D014839:Vomiting / Q000150:complications* / Q000235:genetics / Q000473:pathology