Perianal metastasis from a sigmoid carcinoma--objective evidence of a clonal origin. Report of a case.
A case is described in which flow cytometric DNA analysis of a sigmoid cancer and a subsequently diagnosed anal malignancy demonstrated the same DNA aneuploid pattern in both tumors. The ability to show, by this technique of DNA analysis, that an anal malignancy has seeded from a colon cancer could be important for future therapy. This is because the positive identification of such a deposit as a "dropped" metastasis would prevent inappropriately radical surgery.
Scott
N A
NA
Mayo Clinic, Rochester, Minnesota 55905.
Taylor
B A
BA
Wolff
B G
BG
Lieber
M M
MM
D000230:Adenocarcinoma / Q000235:genetics / Q000556:secondary*; D000368:Aged; D000818:Animals; D001005:Anus Neoplasms / Q000235:genetics / Q000556:secondary*; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D011003:Ploidies; D012811:Sigmoid Neoplasms / Q000235:genetics
D004273:DNA, Neoplasm