title: Effects of iontophoretically applied cortisol on tuberoinfundibular neurons in hypothalamic paraventricular nucleus of anesthetized rats.
abstract: Effects of cortisol on 22 tuberoinfundibular (TI) neurons in the paraventricular nucleus (PVN) of the hypothalamus were examined in urethane-anesthetized rats. Iontophoretically applied cortisol excited 10 (45%) of 22 TI-neurons tested, whereas the cortisol inhibited 4 (31%) of 13 neurons in the periventricular hypothalamic nucleus. Intravenously applied cortisol (0.5 mg in 0.5 ml saline) excited 4 (36%) of 11 TI neurons tested and inhibited 1 (9%). These results suggest that cortisol may have an excitatory effect on TI neurons in the PVN.
authors: Department of Physiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
authors: M
authors: M
authors: Kasai
authors: H
authors: H
authors: Kannan
authors: Y
authors: Y
authors: Ueta
authors: T
authors: T
authors: Osaka
authors: K
authors: K
authors: Inenaga
authors: H
authors: H
authors: Yamashita
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004558:Electric Stimulation; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D007478:Iontophoresis; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006854:Hydrocortisone