Pharmacokinetics of high and moderate intravenous doses of methotrexate.
The pharmacokinetic parameters of methotrexate in nine cancer patients receiving 250-2500 mg/day were investigated. Both elimination rate constants and half-lives were calculated using a two-compartmental open model. The plasma levels-time profiles revealed a biphasic response with a mean initial elimination half-life of 2.3 +/- 0.2 hours and a terminal elimination half-life of 32.2 +/- 7.2 hours.
Awidi
A
A
Faculty of Medicine, University of Jordan, Amman.
al-Turk
A
A
Madanat
F
F
Othman
S
S
Shaheen
O
O
D000293:Adolescent; D000328:Adult; D000368:Aged; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008727:Methotrexate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008875:Middle Aged; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism
D008727:Methotrexate