[Enhancement of antitoxic immunity in newborn infants by peroral administration of donor antistaphylococcal immunoglobulin].
The possibility of enhancing specific immunity by the oral administration of homologous antistaphylococcal immunoglobulin in a dose of 50 I. U./kg b. w. before the first feeding was shown in 75 newborn infants with a high risk of staphylococcal infection. 24 hours after the first administration of Ig the titer of staphylococcal anti-alpha toxin in the blood rose from 0.68 +/- 0.05 I. U./ml to 2.9 +/- 0.14 I. U/ml, on day 7 this titer persisted at the level of 2.86 +/- 0.12 I. U./ml, and 3 months later the titer was 1.5 +/- 0.05 I. U./ml. No side effects were observed. In the reference group (50 infants) antitoxic titers remained low. No suppurative-septic diseases were observed in the test group within 3 months, while in the controls, focal forms of staphylococcal infection (12 cases) and sepsis (1 case) were registered.
Manolova
E P
EP
Tret'iakevich
Z N
ZN
Khripko
S V
SV
Mechetnaia
I N
IN
D000284:Administration, Oral; D000818:Animals; D000992:Antitoxins / Q000032:analysis; D001427:Bacterial Toxins / Q000276:immunology; D001782:Blood Donors; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006460:Hemolysin Proteins; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage* / Q000276:immunology; D007231:Infant, Newborn; D007234:Infant, Premature; D051381:Rats; D013210:Staphylococcus / Q000276:immunology*; D013997:Time Factors
D000992:Antitoxins; D001427:Bacterial Toxins; D006460:Hemolysin Proteins; D007136:Immunoglobulins; C021091:staphylococcal alpha-toxin
Povyshenie antitoksicheskogo immuniteta u novorozhdennykh deteĭ putem peroral'nogo vvedeniia donorskogo antistafilokokkovogo immunoglobulina.