The response of depressed inpatients to isocarboxazid.
Fifty-six inpatients with unipolar depression completed treatment with isocarboxazid. In comparing the differences between responders and nonresponders, it was found that psychomotor retardation, pathological guilt, daily persistence of unremitting symptoms, phobic anxiety, dexamethasone suppression test nonsuppression, and neuroticism were significantly more common among nonresponders. Reactivity of mood, blaming others, and extraversion were more common in responders. Total endogenous depression scores on the Newcastle 1, Newcastle 2, and Michigan scales were also significantly higher in nonresponders. Attained platelet monoamine oxidase inhibition was similar in both groups.
Davidson
J
J
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710.
Lipper
S
S
Pelton
S
S
Miller
R D
RD
Hammett
E B
EB
Mahorney
S
S
Varia
I M
IM
D000328:Adult; D000339:Affect / Q000187:drug effects; D017109:Akathisia, Drug-Induced; D003866:Depressive Disorder / Q000188:drug therapy*; D003907:Dexamethasone; D005260:Female; D006801:Humans; D007520:Isocarboxazid / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales
D007520:Isocarboxazid; D003907:Dexamethasone