title: Effects of autonomic denervation on canine exocrine pancreatic secretion and blood flow.
abstract: The effect of autonomic denervation on the exocrine pancreatic secretion and blood flow was studied in a group of dogs. Pancreatic secretion was collected and analyzed for volume and bicarbonate by direct cannulation of the main papilla through a duodenotomy prior to and following truncal vagotomy and celiac plexus denervation. Pancreatic blood flow was determined by the radioisotope distribution method (141Ce). Truncal vagotomy causes a reduction in pancreatic secretion of volume and bicarbonate by 25-30%, while celiac denervation caused a reduction of 70% in the secretion. The mean baseline pancreatic blood flow was 0.5 ml/g pancreas/min. Truncal vagotomy did not cause any significant flow changes, while celiac denervation caused a significant increase in blood flow of 350% (to 1.75 ml/g/min). These results suggest that both the parasympathetic and the sympathetic system affect pancreatic secretion independently of their effect upon pancreatic blood flow.
authors: Department of Surgery, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors: E
authors: E
authors: Klein
authors: A
authors: A
authors: Salinas
authors: E
authors: E
authors: Shemesh
authors: D A
authors: DA
authors: Dreiling
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D003714:Denervation; D004285:Dogs; D010179:Pancreas / Q000294:innervation* / Q000502:physiology; D010189:Pancreatic Juice / Q000378:metabolism*; D012039:Regional Blood Flow; D014628:Vagotomy