The treatment of donovanosis (granuloma inguinale).
Over a two-year period, 37 patients with genital ulcer disease attending a clinic for sexually transmitted diseases in Harare were found to have donovanosis. Of the 37 patients, 25 were male, and 12 were female; all presented with painless, indurated, granulating ulcers without lymph-node involvement. The lesions were more extensive in pregnant women. All patients responded well to either a combination of intramuscular streptomycin plus oral tetracycline given over 14 days, or a 14-day course of oral co-trimoxazole (trimethoprim-sulfamethoxazole). No metastatic lesions were found.
Latif
A S
AS
Department of Medicine, Medical School, University of Zimbabwe, Harare.
Mason
P R
PR
Paraiwa
E
E
D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006100:Granuloma Inguinale / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D013307:Streptomycin / Q000627:therapeutic use*; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000627:therapeutic use*; D013752:Tetracycline / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use*
D014295:Trimethoprim; D013752:Tetracycline; D013420:Sulfamethoxazole; D013307:Streptomycin