Central nervous system and cardiac manifestations of hydrochlorothiazide overdosage; treatment with hemodialysis.
A patient with end-stage renal failure inadvertently received high-dose hydrochlorothiazide as treatment for hypertension, resulting in CNS and cardiac toxicity. These toxic manifestations were successfully treated with hemodialysis. A hydrochlorothiazide dialysance of 62.5 mL/min was demonstrated. The possibility of hydrochlorothiazide toxicity should be considered in any patient with renal insufficiency who exhibits unexplained arrhythmias or symptoms related to the CNS.
Zahid
M
M
Department of Medicine, Northwestern University Medical School, Chicago, IL.
Krumlovsky
F A
FA
Roxe
D
D
del Greco
F
F
Mistovich
M
M
D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D002490:Central Nervous System / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D006801:Humans; D006852:Hydrochlorothiazide / Q000506:poisoning*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008508:Medication Errors; D006435:Renal Dialysis
D006852:Hydrochlorothiazide