Evaluation of rapid drying hand disinfectant preparations in the intensive care unit.
MK412A (0.2% chlorhexidine in 70% ethanol) and MK412B (0.2% benzalkonium chloride in 70% ethanol), which are rapid drying and rubbing antiseptic preparations, have been evaluated for hand sterilization over a month by ICU nurses. They have been shown to have effective skin decontaminant efficacy under practical conditions in a busy ICU. There were no adverse reactions except for two cases of mild erythema in the MK412A treatment group. In a comparative in vitro study with Pseudomonas cepacia, 0.2% chlorhexidine solution alone and 0.2% benzalkonium chloride solution alone were less bactericidal than MK412A and MK412B.
Tanaka
K
K
Department of Intensive Care, National Cardiovascular Center, Osaka, Japan.
Kumon
K
K
Hirata
T
T
Yamamoto
F
F
Fujita
T
T
D001548:Benzalkonium Compounds / Q000494:pharmacology*; D002710:Chlorhexidine / Q000494:pharmacology*; D004202:Disinfectants / Q000008:administration & dosage*; D004341:Drug Evaluation; D006235:Hand Disinfection; D006801:Humans; D007362:Intensive Care Units; D011549:Pseudomonas / Q000187:drug effects / Q000302:isolation & purification; D012867:Skin / Q000382:microbiology
D001548:Benzalkonium Compounds; D004202:Disinfectants; D002710:Chlorhexidine