Hürthle cell tumors of the thyroid. A flow cytometric DNA analysis.
Twenty-five Hürthle cell tumors of the thyroid gland, histopathologically classified into three groups--adenomas, carcinomas, and indeterminant--have been studied by DNA flow cytometry using archived, paraffin-embedded tissues. Tumor ploidy characteristics were correlated with patient follow-up and survival with the conclusions that (1) nuclear DNA ploidy alone does not distinguish benign from malignant Hürthle cell tumors; (2) diploid DNA Hürthle cell carcinomas behave far less aggressively than aneuploid Hürthle cell carcinomas; and (3) all patients with aneuploid carcinomas died of their disease or are alive with persistent carcinoma.
el-Naggar
A K
AK
Department of Anatomic Pathology, University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute, Houston 77030.
Batsakis
J G
JG
Luna
M A
MA
Hickey
R C
RC
D000236:Adenoma / Q000032:analysis / Q000145:classification / Q000473:pathology*; D002277:Carcinoma / Q000032:analysis / Q000145:classification / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis; D005434:Flow Cytometry; D006801:Humans; D011003:Ploidies; D013964:Thyroid Neoplasms / Q000032:analysis / Q000145:classification / Q000473:pathology*
D004273:DNA, Neoplasm