A quantitative method to evaluate the quality of interrupted animal cultures in aging studies.
A method is described for a quantitative estimation of the quality of interrupted animal cultures. It is applicable when survival can be described by a Weibull or by a Gompertz function. Application to four healthy and three infected cultures of Lymnaea stagnalis shows that survival curves can be successfully predicted from cultures censored at 25%, 50%, and 75% survival. The parameters of these predicted survival curves can be used to evaluate experimental results from single (longitudinal or cross-sectional) aging studies, and to evaluate comparisons among different aging studies.
Slob
W
W
Center for Mathematical Methods, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
Janse
C
C
D000375:Aging / Q000502:physiology*; D000818:Animals; D008195:Lymnaea / Q000502:physiology; D008954:Models, Biological