title: Acute posterior multifocal placoid pigment epitheliopathy and cerebral vasculitis.
abstract: Four cases of suspected cerebral vasculitis have been described in association with acute posterior multifocal placoid pigment epitheliopathy, but none was confirmed histopathologically. We describe a patient who developed fatal cerebral vasculitis after placoid pigment epitheliopathy. Histopathologic data revealed a focal granulomatous inflammation of medium-sized arteries in the leptomeninges. Multinucleated giant cells were a conspicuous part of the inflammatory reaction. The cause of both placoid pigment epitheliopathy and cerebral vasculitis remains obscure.
authors: Department of Ophthalmology, University of Cincinnati College of Medicine, OH.
authors: C A
authors: CA
authors: Wilson
authors: E A
authors: EA
authors: Choromokos
authors: R
authors: R
authors: Sheppard
mesh_terms: D000208:Acute Disease; D000328:Adult; D001927:Brain Diseases / Q000150:complications* / Q000473:pathology; D005128:Eye Diseases / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D010857:Pigment Epithelium of Eye / Q000473:pathology; D014657:Vasculitis / Q000150:complications* / Q000473:pathology