Cadmium chloride induces contractions of the rat isolated urinary bladder by activation of capsaicin-sensitive sensory nerves.
Cadmium chloride (CdCl2)(30 microM-1 mM) produced a concentration-related contraction of the rat isolated urinary bladder which was abolished by tetrodotoxin (1 microM) or extrinsic bladder denervation (72 h before). Complete cross-desensitization was observed between the contractile response to Cd and capsaicin, indicating that, at the peripheral level, this inorganic calcium channel blocker can activate the 'efferent' function of capsaicin-sensitive sensory nerves.
Patacchini
R
R
Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
Santicioli
P
P
Giuliani
S
S
Maggi
C A
CA
Meli
A
A
D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D002211:Capsaicin / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011984:Sensory Receptor Cells / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation*
D002104:Cadmium; D002211:Capsaicin