Renal handling of hypoxanthine and xanthine in normal subjects and in four cases of idiopathic renal hypouricemia.
Pyrazinamide (PZA) was used to study the renal handling of hypoxanthine, xanthine and uric acid in 2 normal subjects and in 4 patients with idiopathic renal hypouricemia; one patient was classified as having a postsecretory reabsorption defect, whereas the others were classified as having a presecretory reabsorption defect. In normal subjects, PZA suppressed strongly the excretion of xanthine as well as uric acid; however, it showed a weak effect on that of hypoxanthine. PZA suppressed all excretion of these 3 compounds in the patient with postsecretory reabsorption defect. PZA showed almost no effect on the excretion of either hypoxanthine, xanthine or uric acid in the patients with presecretory reabsorption defect.
Kaneko
K
K
Second Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Fujimori
S
S
Itoh
H
H
Nakayama
Y
Y
Oyama
H
H
Kanbayashi
T
T
Miyashita
H
H
Akaoka
I
I
D000328:Adult; D005260:Female; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000652:urine*; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000097:blood* / Q000652:urine; D008297:Male; D008875:Middle Aged; D011718:Pyrazinamide; D012016:Reference Values; D014527:Uric Acid / Q000097:blood* / Q000652:urine; D019820:Xanthine; D014970:Xanthines / Q000652:urine*
D007042:Hypoxanthines; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D011718:Pyrazinamide; D019271:Hypoxanthine