title: Dietary and other characteristics relevant for coronary heart disease in men of Indian, West Indian and European descent in London.
abstract: The origins of the high standardized mortality ratio (SMR) for coronary heart disease (CHD) among Indians in Britain, and the low SMR for West Indian immigrants, have been explored by a community survey in London. Serum lipoproteins, plasma glucose, haemostatic factors and other putative risk characteristics were measured in 75 Indian, 64 European and 24 West Indian men aged 45-54 years. These represented 81% of men registered with a general practice and resident within a defined area. In 51 men, diet was assessed by 5-day weighed inventory. Plasma phospholipid fatty acids (PFA) were measured in 18 Indians and 19 Europeans with dietary records. The relatively high HDL and HDL2-cholesterol concentrations, low LDL-cholesterol concentration, reduced fat intake, increased ratio of dietary polyunsaturated/saturated fat, relatively frequent use of alcohol, and lack of obesity in West Indians accorded with their low SMR from CHD. By contrast, only the relatively low HDL and HDL2-cholesterol concentrations, infrequency of alcohol consumption, and lower proportion of PFA as n-3 fatty acids of marine origin afforded explanations for the high SMR of Indians. Hyperglycaemia appeared similarly prevalent in Indians and West Indians, but less common in Europeans. Of the haemostatic factors, West Indians had a relatively low VIIc (not statistically significant), while Indians had an increased platelet count and reduced platelet volume. Improved understanding of these ethnic differences in CHD mortality may depend upon elucidation of the contrasts in HDL-cholesterol concentration.
authors: Medical Research Council, Northwick Park Hospital, Harrow, Middlesex, U.K.
authors: G J
authors: GJ
authors: Miller
authors: S
authors: S
authors: Kotecha
authors: W H
authors: WH
authors: Wilkinson
authors: H
authors: H
authors: Wilkes
authors: Y
authors: Y
authors: Stirling
authors: T A
authors: TA
authors: Sanders
authors: A
authors: A
authors: Broadhurst
authors: J
authors: J
authors: Allison
authors: T W
authors: TW
authors: Meade
mesh_terms: D001780:Blood Coagulation Tests; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D004032:Diet; D005060:Europe / Q000208:ethnology; D005231:Fatty Acids, Unsaturated / Q000097:blood; D006801:Humans; D007194:India / Q000208:ethnology; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014900:West Indies / Q000208:ethnology
chemical_list: D001786:Blood Glucose; D005231:Fatty Acids, Unsaturated; D008074:Lipoproteins; D002784:Cholesterol