The non-random occurrence of exchanges involving chromosomes 7 and 14 in human lymphocytes: a prospective study of control individuals.
A prospective banded study of chromosome aberrations in 77 control individuals showed an excess of exchanges involving chromosomes 7 and 14 in peripheral blood lymphocyte cultures. Analysis of 3850 cells, in their first mitosis in vitro, revealed 5 t(7;14), 4 inv(7), 1 inv(14) and 1 dic(14;14). It is suggested that these exchanges are a specific T-cell phenomenon and are already present in the peripheral blood lymphocytes prior to culturing.
Tawn
E J
EJ
Geoffrey Schofield Cytogenetics Laboratory, BNF plc, Seascale, Cumbria, Great Britain.
D002869:Chromosome Aberrations; D007446:Chromosome Inversion; D002883:Chromosomes, Human, Pair 14; D002897:Chromosomes, Human, Pair 7; D004781:Environmental Exposure; D006801:Humans; D008214:Lymphocytes; D008934:Mitogens; D011446:Prospective Studies; D012907:Smoking; D014178:Translocation, Genetic
D008934:Mitogens