Modulation of adrenergic receptors during aging.
In aging there is not only a reduced density of adrenergic receptors but also a reduced capacity to adapt these receptors to a changing neuronal input or hormonal environment. A reduced density of receptors presumably would result in a decreased ability of aged individuals to respond to stimulation of these receptors, and a reduced ability to modulate these receptors would result in a decreased capacity to adapt their responses to a changing internal or external environment. Future studies should be directed at the genomic mechanisms that control receptor synthesis.
Weiss
B
B
Department of Pharmacology, Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia.
D000222:Adaptation, Physiological; D000375:Aging / Q000502:physiology*; D000818:Animals; D001696:Biomechanical Phenomena; D005246:Feedback; D006706:Homeostasis; D006801:Humans; D010870:Pineal Gland / Q000378:metabolism / Q000502:physiology; D011941:Receptors, Adrenergic / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*
D011941:Receptors, Adrenergic