Ligand-binding properties of albumin Parklands: Asp365----His.
An albumin variant, isolated from the plasma of a patient with bisalbuminemia, was compared with albumin A from the same patient for binding of long-chain fatty acids and bilirubin. No differences in binding of [14C]palmitate, cis-parinaric acid or bilirubin could be detected for the variant form. These results suggest that the region adjacent to residue 365 is unlikely to be part of a major binding site for any of these ligands.
Reed
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Medical Research Institute, Mary Imogene Bassett Hospital, Cooperstown, NY 13326.
D001663:Bilirubin / Q000378:metabolism*; D001665:Binding Sites; D005227:Fatty Acids / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D006801:Humans; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*; D000075462:Serum Albumin, Human; D013053:Spectrophotometry
D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D010169:Palmitic Acids; D012709:Serum Albumin; C055854:albumin Parklands; D019308:Palmitic Acid; C013641:parinaric acid; D001663:Bilirubin; D000075462:Serum Albumin, Human