Localization of 99mTc-diphosphonates in newly formed bone matrix as a measure of bone lesion detectability.
The lesion-to-normal-bone ratios of DBA-MDP (dibutylamino-methylene-diphosphonate), DPD (dicarboxypropane-diphosphonate) and MDP (methylene-diphosphonate) each labeled with 99mTc, were evaluated in experimental bone lesions. In 3-day old lesions this ratio was increased twofold for DBA-MDP in comparison with MDP and DPD which showed nearly equal ratios. Later on these differences became negligibly small. It is concluded that 99mTc-DBA-MDP is fixed more strongly in the immature bone matrix and that this will lead to an improvement in the detectability of lesions containing larger amounts of immature bone matrix.
Schuemichen
C
C
Department of Nuclear Medicine, Albert-Ludwigs-University, Freiburg i. Br., FRG.
Krause
T
T
Umbach
G
G
Wolff
T
T
D000818:Animals; D001857:Bone Matrix / Q000378:metabolism*; D004164:Diphosphonates / Q000493:pharmacokinetics*; D050723:Fractures, Bone / Q000000981:diagnostic imaging*; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics; D013997:Time Factors; D014018:Tissue Distribution
D004164:Diphosphonates; C055815:technetium Tc 99m dibutylaminomethylenediphosphonate; D013667:Technetium; D013669:Technetium Tc 99m Medronate