Effects of aminocycloalkanesulfonic acid analogs of taurine on ATP-dependent calcium ion uptake and protein phosphorylation.
A cyclopentane analog of taurine [(+/-)cis-2-aminocyclopentanesulfonic acid] (CAPS) was synthesized, and its effects on ATP-dependent calcium ion uptake and protein phosphorylation in rat retina were investigated along with other cyclic analogs of taurine, (+/-)trans-2-Aminocyclopentanesulfonic acid (TAPS) is the most potent aminocycloalkanesulfonic acid inhibitor of ATP-dependent calcium ion uptake in retinal homogenates [S.M. Leibowitz, J.B. Lombardini and P.S. Salva, Biochem. Pharmac. 36, 2109 (1987)], eliciting its effects in the micromolar range (I50 = 39 +/- 5 microM). CAPS was found to be a less potent aminocycloalkanesulfonic acid inhibitor (I50 = 1780 +/- 400 microM) of ATP-dependent calcium ion uptake in retinal homogenates. Taurine inhibited phosphate incorporation into rat retinal proteins, whereas TAPS, TAHS and CAPS stimulated incorporation.
Liebowitz
S M
SM
Division of Medicinal Chemistry, College of Pharmacy, University of Texas, Austin 78712.
Lombardini
J B
JB
Allen
C I
CI
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003514:Cyclohexylamines / Q000494:pharmacology; D003517:Cyclopentanes / Q000494:pharmacology; D066298:In Vitro Techniques; D010766:Phosphorylation; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000031:analogs & derivatives / Q000494:pharmacology*
D003514:Cyclohexylamines; D003517:Cyclopentanes; D011506:Proteins; C052782:2-aminocyclopentanesulfonic acid; C052781:2-aminocyclohexanesulfonic acid; D013654:Taurine; D000255:Adenosine Triphosphate; D002118:Calcium