Prolactin response to tryptophan during mianserin treatment.
Unlike tricyclic antidepressants and monoamine oxidase inhibitors, mianserin did not increase prolactin response to the 5-hydroxytryptamine (5-HT) precursor tryptophan in nine patients with major depression. Antidepressant drugs apparently produce dissimilar effects on this aspect of brain 5-HT function in depressed patients.
Cowen
P J
PJ
Department of Psychiatry, Oxford University, United Kingdom.
D000328:Adult; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000627:therapeutic use*; D008875:Middle Aged; D010043:Outcome and Process Assessment, Health Care; D011388:Prolactin / Q000097:blood*; D011569:Psychiatric Status Rating Scales; D012701:Serotonin / Q000096:biosynthesis; D014364:Tryptophan / Q000378:metabolism / Q000494:pharmacology*
D008803:Mianserin; D012701:Serotonin; D014364:Tryptophan; D011388:Prolactin