Clonal chromosome rearrangements in a uterine myoma.
A cytogenetic study of a myoma of uterus with extensive hyaline, myxoid, and cystic degeneration revealed a clonal karyotype with a complex structural rearrangement involving chromosomes #3, #12, #14, #17, and #22. The modal chromosome number of the tumor was 45 due to monosomy #22. Analysis of seven additional myomas of the uterus including five tumors with typical histology and two with degenerative changes showed no clonal abnormalities. Single metaphases with a trisomy and a translocation were detected in two tumors. We conclude that although many uterine myomas appear to have normal karyotypes, clonal chromosome abnormalities are present in some of these tumors.
Gibas
Z
Z
Department of Pathology, Medical College of Pennsylvania, Philadelphia 19129.
Griffin
C A
CA
Emanuel
B S
BS
D000328:Adult; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D011003:Ploidies; D014594:Uterine Neoplasms / Q000235:genetics* / Q000473:pathology