[A case of advanced gastric cancer responsive to intratumoral OK-432 injection].
An 83-year-old patient with advanced gastric cancer was given repeated endoscopic administration of OK-432 combined with systemic immunochemotherapy. The cancerous lesion gradually regressed following the treatment, and remarkable degeneration was observed in many tumor cells. Detailed immunohistochemical examination revealed that Leu 7-positive cells had markedly infiltrated the cancerous tissue. This finding suggests that NK cells may play an important role in tumor regression induced by intratumoral OK-432 therapy.
Sakai
Y
Y
Dept. of Internal Medicine, Yokosuka Kyosai Hospital, Kanagawa, Japan.
Maeda
M
M
Koyama
W
W
Totsuka
S
S
Sakamoto
S
S
Kanayama
M
M
D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D000368:Aged; D001688:Biological Products / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D010844:Picibanil / Q000008:administration & dosage* / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*
D001688:Biological Products; D010844:Picibanil