[Delayed antihypoxic effect of leu enkephalin in mice].
Hypobaric hypoxic hypoxia conditions were simulated by raising mice in the altitude chamber to the level of 10,500-10,700 m. Enkephalin, its analogues, morphine and naloxone were injected once 1, 2, 3, 6 and 14 days prior to the experiment, and then their effects on stability to hypoxia were investigated depending on the time of drug administration. Only leu-enkephalin after a single injection was found to have antihypoxic properties for a week. Naloxone, but not phentolamine hydrochloride, blocked delayed antihypoxic effect of penta-peptide. Leu-enkephalin is thought to be endogenous antihypoxant.
Iasnetsov
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VV
D000818:Animals; D004743:Enkephalin, Leucine / Q000008:administration & dosage*; D000860:Hypoxia / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage; D009270:Naloxone / Q000008:administration & dosage; D013997:Time Factors
D009270:Naloxone; D004743:Enkephalin, Leucine; D009020:Morphine
Otsrochennyĭ antigipoksicheskiĭ éffekt leĭ-énkefalina u mysheĭ.