Haloperidol and apomorphine effects on ethanol reinforcement in free feeding rats.
Free feeding male Long Evans rats were trained to lever press on a Fixed Ratio 8 schedule for 10% ethanol reinforcement. Mean ethanol intake in 30-minute sessions was 0.38 g/kg. Subcutaneous apomorphine (APO: 0.025 to 0.5 mg/kg) and haloperidol (HAL: 0.005 to 0.0625 mg/kg) administered 15 minutes before sessions dose-dependently reduced responding, but only APO reduced momentary response rates. Low doses of HAL reduced the effect of 0.3 but not 0.05 mg/kg APO. When the rats were food-restricted, control response rates decreased, and APO (0.025 and 0.05 mg/kg) had no further effect. Results were discussed in terms of dopamine involvement in the mechanism of ethanol reinforcement.
Pfeffer
A O
AO
Department of Psychology, University of Washington, Seattle 98195.
Samson
H H
HH
D000428:Alcohol Drinking / Q000187:drug effects* / Q000523:psychology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D004298:Dopamine / Q000502:physiology; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012054:Reinforcement, Psychology
D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine