title: In vivo production of thromboxane and prostacyclin in patients following total hip arthroplasty.
abstract: The in vivo production of thromboxane and prostacyclin was studied by measurements of their major urinary metabolites in eight patients undergoing total hip arthroplasty. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha. The excretion of these metabolites increased about 10-fold during the intra and immediate postoperative period and 4 days after surgery was still higher than during the preoperative period. The increased thromboxane formation reflects probable activation of platelets whereas the increased prostacyclin could be part of a vascular defense against induced thrombotic activity. These findings may have pathophysiological implications.
authors: Department of Clinical Chemistry and Blood Coagulation, Karolinska Hospital, Stockholm, Sweden.
authors: O
authors: O
authors: Vesterqvist
authors: U
authors: U
authors: Schött
authors: O
authors: O
authors: Berséus
authors: K
authors: K
authors: Axelsson
authors: K
authors: K
authors: Gréen
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000031:analogs & derivatives* / Q000652:urine; D000368:Aged; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D013927:Thrombosis / Q000209:etiology; D013929:Thromboxane B2 / Q000031:analogs & derivatives* / Q000652:urine
chemical_list: D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; C028965:2,3-dinor-thromboxane B2; C028290:2,3-dinor-6-ketoprostaglandin F1alpha