title: Tumor necrosis factor-alpha up-regulates expression of secretory component, the epithelial receptor for polymeric Ig.
abstract: Secretory component (SC) is the receptor that facilitates transcytosis of polymeric IgA and polymeric IgM through secretory epithelial cells and into exocrine fluids. The present study showed that rTNF-alpha enhanced the cellular pool, membrane expression, and secretion of functionally SC in a human colonic carcinoma cell line (HT-29m2) which is known to express and process SC like normal glandular cells. TNF-alpha also up-regulated membrane expression of the constitutive HLA class I molecules, whereas the cells remained HLA class II-negative.
authors: Institute of Pathology, University of Oslo, Rikshospitalet, Norway.
authors: D
authors: D
authors: Kvale
authors: D
authors: D
authors: Løvhaug
authors: L M
authors: LM
authors: Sollid
authors: P
authors: P
authors: Brandtzaeg
mesh_terms: D002462:Cell Membrane / Q000276:immunology / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism*; D006680:HLA Antigens / Q000378:metabolism; D006801:Humans; D007128:Immunoglobulin Fragments / Q000378:metabolism*; D007075:Immunoglobulin M / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism*; D012635:Secretory Component / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
chemical_list: D006680:HLA Antigens; D007128:Immunoglobulin Fragments; D007075:Immunoglobulin M; D011971:Receptors, Immunologic; D012635:Secretory Component; D014409:Tumor Necrosis Factor-alpha; C024242:polymeric IgM