HLA and multiple skin carcinomas.
The presence of HLA-associated genetic factors in patients with multiple skin carcinomas was investigated. 43 patients affected by multiple basal and squamous cell carcinomas and 220 healthy age-matched controls were typed for 72 HLA-A, B, C, DR antigens. A negative association of B-17 (mostly B-58) and a positive association of Cw-3 and DR-1 was observed in patients with multiple basal cell carcinomas; a similar negative association with B-58 and positive association with DR-1 was seen in patients with squamous cell carcinomas. The results of this study suggest the presence of resistance factors to the development of skin cancers associated with B-17 (B-58) antigen.
Cerimele
D
D
Institute of Dermatology, University of Sassari, Italy.
Contu
L
L
Carcassi
C
C
Costa
G
G
La Nasa
G
G
Sanna
E
E
Campus
G V
GV
D002280:Basal Cell Carcinoma / Q000235:genetics / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D006681:HLA-D Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology*
D006680:HLA Antigens; D006681:HLA-D Antigens; D006684:HLA-DR Antigens