A model to test grafts in the venous system under varying flow conditions.
Ligation of suprarenal or inter-renal vena cava reduces caval flow by 59% and 89%, respectively, in Sprague-Dawley rats. This was used as a model to test grafts under varying flow conditions. PTFE-grafts, homologous vein grafts and peritoneal tube grafts of about 2 mm in diameter were tested. The vena cava was replaced with one of the grafts (5-16 mm in length) as an interposition graft and the animals were followed for more than 3 months. High patency rates were found during all flow conditions with PTFE-grafts and vein grafts and during normal flow with peritoneal tube grafts. Despite the small diameter of the grafts and the severely reduced flow it seemed thus possible to maintain patency with both biological and prosthetic material.
Ribbe
E B
EB
Department of Surgery, Lund University, Sweden.
Bengmark
S B
SB
D000818:Animals; D001807:Blood Vessel Prosthesis; D008297:Male; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D014654:Vascular Patency; D014682:Vena Cava, Inferior / Q000503:physiopathology* / Q000601:surgery