Radiation sensitivity and DNA repair in Caenorhabditis elegans strains with different mean life spans.
The sensitivities to three DNA damaging agents (UV and gamma-radiation, methyl methanesulfonate) were measured in four recombinant inbred (RI) strains of Caenorhabditis elegans with mean life spans ranging from 13 to 30.9 days, as well as in the wild-type strains used to derive these RI's. Sensitivities at several stages in the developmental cycle were tested. There were no significant correlations between mean life span and the lethal effects of these 3 agents. Excision of two UV-radiation-induced DNA photoproducts was also measured. Long-lived strains were no more repair competent than shorter-lived strains. These data indicate that DNA repair plays at best a minor role in the aging process of C. elegans.
Hartman
P S
PS
Department of Biology, Texas Christian University, Fort Worth 76129.
Simpson
V J
VJ
Johnson
T
T
Mitchell
D
D
D000818:Animals; D002107:Caenorhabditis / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair; D005720:Gamma Rays; D008136:Longevity; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D011836:Radiation Tolerance; D014466:Ultraviolet Rays
D008741:Methyl Methanesulfonate