Myelin lipids of the rat brain in experimental hypoxia.
The pattern of cerebral myelin lipids was studied in Wistar rats exposed to mild hypoxia (7% of oxygen in a respiratory mixture) for 30 min. The most pronounced change involved a marked increase in cholesterol esters and lysophosphatidylcholine content in the myelin fraction. The results obtained indicate that mild hypoxia induces a lesion of myelin membranes but does not provoke the reaction of lymphocytes and macrophages, which by production of myelinolytic factors, evoke demyelination.
Wender
M
M
Department of Neurology, School of Medicine, Poznań, Poland.
Adamczewska-Goncerzewicz
Z
Z
Stanisławska
J
J
Pankrac
J
J
Talkowska
D
D
Grochowalska
A
A
D000818:Animals; D001923:Brain Chemistry; D002788:Cholesterol Esters / Q000378:metabolism; D002534:Hypoxia, Brain / Q000378:metabolism*; D050356:Lipid Metabolism; D008244:Lysophosphatidylcholines / Q000378:metabolism; D009186:Myelin Sheath / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D002788:Cholesterol Esters; D008244:Lysophosphatidylcholines; D010743:Phospholipids