Human placenta gangliosides.
Gangliosides extracted from human placenta were composed of four major components (G1-G4), which were purified by silica beads column chromatography. The structures of these gangliosides were analyzed by exoglycosidase treatments, 400 MHz proton magnetic resonance spectroscopy and gas chromatography-mass spectrometry and were concluded to be as follows: (Formula: see text). Gangliosides containing more than 10 sugar residues were observed in addition to the above four major components. But ganglio-series gangliosides were undetectable in the placenta.
Taki
T
T
Department of Biochemistry, Shizuoka College of Pharmacy, Japan.
Matsuo
K
K
Yamamoto
K
K
Matsubara
T
T
Hayashi
A
A
Abe
T
T
Matsumoto
M
M
D000606:Amino Sugars / Q000032:analysis; D001789:Blood Group Antigens / Q000032:analysis; D002240:Carbohydrate Sequence; D005260:Female; D005732:Gangliosides / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D006026:Glycoside Hydrolases / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D010920:Placenta / Q000032:analysis*; D011247:Pregnancy
D000606:Amino Sugars; D001789:Blood Group Antigens; D005732:Gangliosides; C032233:lactosamine; D006026:Glycoside Hydrolases