Influence of food on bioavailability of amdinocillin pivoxil.
The bioavailability of amdinocillin was not altered when amdinocillin pivoxil was ingested 1 h before a standard breakfast, and it increased by 20% when amdinocillin pivoxil was ingested with or 1 h after a standard breakfast. Amdinocillin pivoxil would be convenient for patients since it may be taken with or without food.
Bornemann
L D
LD
Pharmaceutical Research and Development, Hoffmann-La Roche Inc., Nutley, New Jersey 07110.
Castellano
S
S
Lin
A H
AH
Enthoven
D
D
Patel
I H
IH
D000284:Administration, Oral; D000328:Adult; D000560:Amdinocillin / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D000561:Amdinocillin Pivoxil / Q000009:adverse effects / Q000493:pharmacokinetics*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005502:Food; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation
D000561:Amdinocillin Pivoxil; D000560:Amdinocillin