[Positive modulation of diazepam activity by cortexolone in alcoholic rats].
It has been shown that glucocorticoid receptor antagonist-cortexolone--increased anxiolytic action of diazepam in alcoholic rats. Neither diazepam (2 mg/kg), nor cortexolone (20 mg/kg) alone influenced voluntary ethanol consumption in alcoholic rats during 14 days of administration, however, combined administration of diazepam and cortexolone diminished ethanol consumption. Receptor and permissive mechanism of gluco- and antiglucocorticoid effect on the action of diazepam are being discussed.
Vedernikova
N N
NN
Borisova
I P
IP
Orekhov
S N
SN
D015065:17-Hydroxycorticosteroids / Q000008:administration & dosage*; D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D003350:Cortodoxone / Q000008:administration & dosage* / Q000494:pharmacology; D003975:Diazepam / Q000008:administration & dosage* / Q000494:pharmacology; D004338:Drug Combinations; D008297:Male; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D015065:17-Hydroxycorticosteroids; D004338:Drug Combinations; D011965:Receptors, Glucocorticoid; D003975:Diazepam; D003350:Cortodoxone
Pozitivnaia moduliatsiia aktivnosti diazepama u alkogolizirovannykh krys pri pomoshchi korteksolona.