title: Prevalence of ABO maternal-infant incompatibility in Asians, Blacks, Hispanics and Caucasians.
abstract: Previous studies suggest that race is a risk factor in ABO hemolytic disease of the newborn (ABO-HDN). In order to compare the prevalence of ABO-HDN in Asian, Black, Hispanic and Caucasian infants, we studied 10,611 consecutive births at one hospital over a 6-year period. Among group A infants born to group O mothers, the prevalence of positive DAT differed among the four groups (p = 0.007), and was highest in Asians (50%) and lowest in Caucasians (31%). However, the proportions of infants who required exchange transfusion were not different (p = 0.351). Among group B infants born to group O mothers, the prevalence of positive DAT was not different among the four groups (p = 0.26) and none of these 166 group B infants with a positive DAT result required exchange transfusion. Our findings suggest that there are small ethnic differences in the prevalence of positive DAT results in group A infants born to group O mothers, but the prevalence of clinical disease which requires exchange transfusion does not differ significantly among Asian, Black, Hispanic and Caucasian infants.
authors: Blood Bank, San Francisco General Hospital Medical Center, Calif.
authors: P T
authors: PT
authors: Toy
authors: M E
authors: ME
authors: Reid
authors: L
authors: L
authors: Papenfus
authors: H H
authors: HH
authors: Yeap
authors: D
authors: D
authors: Black
mesh_terms: D000017:ABO Blood-Group System; D044466:Asian People; D044383:Black People; D003298:Coombs Test; D004899:Erythroblastosis, Fetal / Q000453:epidemiology*; D005006:Ethnicity; D006801:Humans; D007231:Infant, Newborn; D044469:Racial Groups; D044465:White People
chemical_list: D000017:ABO Blood-Group System