title: Serum doxapram and respiratory neuromuscular drive in normal man.
abstract: To investigate the means by which doxapram affects the control of ventilation, ventilatory function and P0.1 have been related to serum doxapram concentration during a 45-min infusion of doxapram hydrochloride in 7 healthy, conscious subjects under normoxic conditions. Serum doxapram concentrations increased during the infusion: 1.88, 2.48, 3.42, and 3.97 micrograms/ml after 5, 10, 30 and 45 min, respectively. The majority of significant changes in the measurements from the baseline were observed at 30 and 45 min: VE, VT, P0.1, P0.1/end-tidal CO2 tension, VT/Ti and blood pressure were increased, and end-tidal CO2 tension was decreased. No significant changes in Pdimax, Ti/Ttot, VE/P0.1, and P0.1/(VT/Ti) were observed. A correlation was observed between the % increases in P0.1 and VE and doxapram concentration, and between VE and P0.1. The doxapram-induced increase in VE appears to be caused by increased neural drive. It is related to the serum drug concentration in the conscious subject.
authors: Department of Pulmonary Disease, Tokyo Teishin Hospital, Japan.
authors: S
authors: S
authors: Okubo
authors: K
authors: K
authors: Konno
authors: T
authors: T
authors: Ishizaki
authors: T
authors: T
authors: Suganuma
authors: T
authors: T
authors: Takubo
authors: T
authors: T
authors: Takizawa
authors: M
authors: M
authors: Tanaka
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003964:Diaphragm / Q000502:physiology; D004315:Doxapram / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008176:Lung Volume Measurements; D008297:Male; D008722:Methods; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D012119:Respiration / Q000187:drug effects*; D012125:Respiratory Center / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D014160:Transducers, Pressure
chemical_list: D004315:Doxapram