Altered leukocyte rheology in patients with chronic cerebrovascular disease.
Erythrocyte and leukocyte suspensions were prepared from 28 patients with chronic cerebrovascular disease and 30 age- and concomitant disease-matched control subjects. Cell filterability was studied with the new St. George's filtrometer, which can discriminate between initial filtration rate as an erythrocyte parameter and filter clogging as a leukocyte parameter. Compared with control subjects, a significant increase of filter clogging was found in the patients, suggesting decreased deformability or increased adhesiveness of leukocytes or both in chronic cerebrovascular disease.
Vermes
I
I
Department of Clinical Chemistry, H.d.K. Hospital, Oldenzaal, The Netherlands.
Strik
F
F
D000368:Aged; D002561:Cerebrovascular Disorders / Q000503:physiopathology*; D002908:Chronic Disease; D004907:Erythrocyte Deformability; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D008875:Middle Aged; D012212:Rheology