[Action of anti-arrhythmia agents in ischemia and hyperoxia].
During experiments (128 rabbits) it was shown that under ischemia and hyperoxia the pharmacodynamics of lidocaine, anaprilin and ethacizine changed in centrogenic and peripheral arrhythmias induced by aconitine. Hyperoxia significantly potentiated the antiarrhythmic effect of the drugs except lidocaine action in centrogenic arrhythmias.
Kedrov
S I
SI
Reznikov
K M
KM
Leonov
A N
AN
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D003327:Coronary Disease / Q000139:chemically induced / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D010100:Oxygen / Q000008:administration & dosage*; D010640:Phenothiazines / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D011817:Rabbits
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D008012:Lidocaine; D011433:Propranolol; C046818:ethacizine; D010100:Oxygen; D000157:Aconitine
Deĭstvie nekotorykh protivoaritmicheskikh sredstv v usloviiakh ishemii i giperoksii.