title: Famotidine in the short-term treatment of duodenal ulcer and of concomitant peptic lesions: comparison with cimetidine.
abstract: Twenty patients affected with endoscopically demonstrated duodenal ulcer were studied. They were randomly divided into two groups of ten individuals each. The first group was treated with famotidine 40 mg/die/os, the second one with cimetidine 800 mg/die/os; both drugs were administered in one medication at bedtime. In each group, eight patients completed the treatment: six out of eight famotidine treated and five out of eight cimetidine treated patients showed ulcer healing on upper digestive endoscopy after four weeks of treatment; after eight weeks of therapy, all patients of both groups displayed ulcer healing. Nevertheless, an overall quantitative evaluation of all peptic lesions (performed according to an endoscopic arbitrary score) indicated a higher effectiveness of famotidine. Famotidine did not affect humoral parameters of renal, hepatic and myelopoietic function and did not significantly change fasting serum gastrin levels.
authors: First Medical Clinic, University of Pisa, Italy.
authors: A
authors: A
authors: Polloni
authors: S
authors: S
authors: Marchi
authors: A
authors: A
authors: Greco
authors: G
authors: G
authors: Cipparrone
authors: F
authors: F
authors: Costa
authors: M
authors: M
authors: Bellini
authors: G
authors: G
authors: Maltinti
mesh_terms: D002927:Cimetidine / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy*; D015738:Famotidine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy*; D013844:Thiazoles / Q000627:therapeutic use*
chemical_list: D013844:Thiazoles; D015738:Famotidine; D002927:Cimetidine