[Effect of ischemia and reperfusion of the rat brain on lipid peroxidation and the protective effect of antioxidants].
The experiments have been performed on 179 Wistar rats to examine the changes in the brain level of lipid peroxidation products upon 5-, 15-, 30- and 60-min ischemia and 5-, 20- and 60-min reperfusion and to study the protective effect of antioxidants. It has been found that ischemia is accompanied by the accumulation of lipid peroxidation products. The content increases by an average of 138-213% of the initial level. Brain reperfusion after 30-min ischemia was accompanied by an increase or maintenance of a high level of lipid peroxidation products. Ionol injection was accompanied by an increase in the survival of rats and prevented the accumulation of lipid peroxidation products after brain ischemia and reperfusion.
Bilenko
M V
MV
Tel'pukhov
V I
VI
Churakova
T D
TD
Komarov
P G
PG
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000378:metabolism* / Q000517:prevention & control; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use; D002560:Cerebrovascular Circulation; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D000975:Antioxidants; D008054:Lipid Peroxides; D002084:Butylated Hydroxytoluene
Vliianie ishemii i reperfuzii golognogo mozga krys na protsessy perekisnogo okisleniia lipidov i zashchitnyĭ éffekt antioksidantov.