Trophoblast membrane infusion for unexplained recurrent miscarriage.
A novel protocol is described which has been developed for immunotherapy in unexplained recurrent miscarriage. This is based on a single intravenous infusion with isolated placental trophoblast plasma membrane vesicle preparations. Clinical experience gained with this approach is described. A total of 16/21 (76%) patients who subsequently had pregnancies have now achieved a live birth or are currently pregnant at greater than 28 weeks gestation.
Johnson
P M
PM
Department of Immunology, University of Liverpool, UK.
Chia
K V
KV
Hart
C A
CA
Griffith
H B
HB
Francis
W J
WJ
D000026:Abortion, Habitual / Q000517:prevention & control*; D000328:Adult; D000954:Antigens, Surface / Q000008:administration & dosage; D002462:Cell Membrane / Q000276:immunology; D005260:Female; D006801:Humans; D007114:Immunization / Q000379:methods*; D011247:Pregnancy; D014327:Trophoblasts / Q000276:immunology*
D000954:Antigens, Surface