[Action of obzidan and isoptin on the indices of free-radical lipid peroxidation of the ischemic myocardium].
Effects of obsidan and isoptine on Fe2+-induced free radical lipid peroxidation (FRLP) were studied according to the data of chemoluminiscence (CL) and malon dialdehyde (MDA) content during experiments on the intact myocardium and at two-thour ischemia of the myocardium as well in the suspension of egg yolk lipoproteids. It was found that in the intact myocardium obsidan (10% LD50) suppressed FRLP according to the CL data, simultaneously increasing MDA level, and in the ischemic myocardium significantly suppressed FRLP by a number of parameters. Isoptine in the intact myocardium exerted no effect on CL with a simultaneous increase of MDA level, and in the ischemic myocardium suppressed FRLP by most parameters. In the suspension of egg yolk lipoproteids obsidan and isoptine changed MDA concentration in a two-phase manner. Isoptine also had a two-phase action on FRLP according to the CL data. A high antioxidative activity of obsidan in the suspension of egg yolk lipoproteids was noted as compared to that of isoptine. Based on the data of kinetics of Fe2+-induced CL in the suspension of egg yolk lipoproteids, obsidan is a true antioxidant by its mechanism of action and ispoptine is a structural antioxidant.
Golovkin
V D
VD
Gukasov
V M
VM
Gatsura
V V
VV
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals; D006321:Heart / Q000187:drug effects*; D006358:Hot Temperature / Q000009:adverse effects; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism; D008163:Luminescent Measurements; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D011433:Propranolol / Q000627:therapeutic use*; D051381:Rats; D014700:Verapamil / Q000627:therapeutic use*
D005609:Free Radicals; D008054:Lipid Peroxides; D008081:Liposomes; D011433:Propranolol; D014700:Verapamil
Deĭstvie obzidana i izoptina na pokazateli perekisnogo svobodnoradikal'nogo okisleniia lipidov ishemizirovannogo miokarda.