title: A factor from the injured lower vertebrate CNS promotes outgrowth from human fetal brain neurons.
abstract: Unlike mammals, lower vertebrates retain the capacity to regenerate damaged central nervous system (CNS) pathways throughout life. In previous studies, we have used the goldfish optic nerve (ON) as a model for CNS regeneration, and found that the injured goldfish ON selectively secretes a factor that promotes process outgrowth of cultured neurons, including neurons of the developing rodent CNS. In the current study, we found that a factor similarly obtained from the injured goldfish ON also has potent outgrowth-promoting effects on cerebrocortical neurons of the fetal human brain, and that these effects are dependent on the age of fetal neurons. This factor appeared to be a protein of mol. wt. greater than 12,000, and was associated with a distinctive morphology of neurite outgrowth. The neurite-promoting factor from the injured goldfish ON may be homologous to factors within the developing human brain.
authors: Mailman Research Center, McLean Hospital, Belmont, MA 02178.
authors: S P
authors: SP
authors: Finklestein
authors: P J
authors: PJ
authors: Apostolides
authors: C G
authors: CG
authors: Caday
authors: M F
authors: MF
authors: Philips
authors: N I
authors: NI
authors: Perrone-Bizzozero
authors: L I
authors: LI
authors: Benowitz
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003470:Culture Media / Q000494:pharmacology*; D003530:Cyprinidae / Q000378:metabolism*; D005625:Frontal Lobe / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D006054:Goldfish / Q000378:metabolism*; D006801:Humans; D008970:Molecular Weight; D009409:Nerve Crush; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009900:Optic Nerve / Q000378:metabolism*
chemical_list: D003470:Culture Media; D009414:Nerve Growth Factors