[Phenobarbital--an inducer of bilignost excretion with the bile in rats].
It was found that a preliminary administration of phenobarbital to rats caused an increase of the rate of 125I-bilignost excretion in the bile by 46.6% but reduced its half-life in the blood by 48.3% and its excretion in the urine by 46.4%. Phenobarbital decreased the rate of 125I-bilignost absorption by the liver slices and increased the rate of release from them.
Shimanovskiĭ
N L
NL
Bolotva
E N
EN
Volkov
A F
AF
Manuĭlov
K K
KK
D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000378:metabolism; D003287:Contrast Media / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007458:Iodipamide / Q000493:pharmacokinetics*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D003287:Contrast Media; D007457:Iodine Radioisotopes; D007458:Iodipamide; D010634:Phenobarbital
Fenobarbital--induktor ékskretsii bilignosta s zhelch'iu u krys.