Effects of taurine on the influx and efflux of calcium in brain slices of adult and developing mice.
45Ca2+ influx was reduced by 10-mM taurine during a 5-min incubation in slices from the cerebral cortex, cerebellum and brainstem of adult mice. In both adult and developing cerebral cortex and cerebellar slices a 30-min exposure to 1.0-mM taurine was likewise effective on resting Ca2+ influx whereas in slices depolarized by 50 mM K+ the influx was not affected. Ca2+ efflux from adult mouse cerebral cortex slices was affected by extracellular Na+ (0-180 mM) but not by K+ (50 mM) or taurine (1 mM). In cerebral cortex slices of 3-day-old mice K+ depolarization stimulated Ca2+ efflux, which effect was antagonized by 1.0 mM taurine. The results suggest that taurine is able to modify Ca2+ influx and efflux in both adult and developing brain but only at relatively high concentrations.
Kontro
P
P
Department of Biomedical Sciences, University of Tampere, Finland.
Oja
S S
SS
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002540:Cerebral Cortex / Q000187:drug effects*; D051379:Mice; D013654:Taurine / Q000494:pharmacology*
D013654:Taurine; D002118:Calcium