Different patterns of rotational behavior in rats after dorsal or ventral striatal lesions with ibotenic acid.
Rats with total, dorsal or ventral ibotenic acid striatal lesions were challenged with DA agonists apomorphine and d-amphetamine. In rats with total lesions, both drugs induced an intense ipsilateral rotation, as did apomorphine in the dorsally lesioned rats. Amphetamine induced ipsilateral rotation in ventrally lesioned rats, but this effect may represent a non-specific potentiation of spontaneous ipsilateral rotation observed in this group. These results indicate that the neostriatum of the rat is not an homogeneous structure concerning the expression of rotational behavior after DA receptor stimulation.
Kafetzopoulos
E
E
Department of Pharmacology, Medical School, University of Ioannina, Greece.
Vlaha
V
V
Konitsiotis
S
S
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D003913:Dextroamphetamine / Q000494:pharmacology; D007051:Ibotenic Acid / Q000633:toxicity*; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010080:Oxazoles / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology
D010080:Oxazoles; D011954:Receptors, Dopamine; D007051:Ibotenic Acid; D001058:Apomorphine; D003913:Dextroamphetamine