The mechanism of cytolytic and cytostatic activity of benfluron.
Benfluron at concentrations of 0.26 and 0.52 mumol l-1 inhibited the formation of V79 colonies in a concentration-dependent way. Diminution of the size of colonies of the treated cells was accompanied by a decrease in protein content per cell. At the same time an increase in metabolic activity was observed. Benfluron blocked the V79 cells in S and G2 phases of the cell cycle and at higher concentrations induced cell lysis documented by alterations in cell membrane permeability and morphology. The in vitro membrane effect of benfluron involved a biphasic modulation of the cardiac sarcolemmal (Na+ + K+)-ATPase activity.
Horáková
K
K
Department of Microbiology and Biochemistry, Slovak Technical University, Bratislava, Czechoslovakia.
Lukácová
D
D
Kozánková
J
J
Dzurba
A
A
Ziegelhöffer
A
A
Jantová
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D005449:Fluorenes / Q000494:pharmacology*; D007700:Kinetics; D008855:Microscopy, Electron, Scanning
D000970:Antineoplastic Agents; D005449:Fluorenes; C034234:VUFB 13468