Specificity of piracetam's anti-amnesic activity in three models of amnesia in the mouse.
The effects of piracetam on the amnesias induced by scopolamine, diazepam and electroconvulsive shock (ECS) were studied in a passive avoidance procedure in the mouse and compared with the interactions of piracetam with the major behavioral effects of these treatments, namely scopolamine-induced hyperactivity, diazepam-induced release of punished behavior (Four Plates Test) and ECS-induced convulsions. Amnesia was induced by injecting scopolamine or diazepam (1 mg/kg, IP) 30 minutes before or applying ECS immediately after the first session (S1) of the passive avoidance task. Piracetam was studied at 3 doses (512, 1024 and 2048 mg/kg) administered PO 60 minutes before S1. Retention was measured 24 hours later (S2) in the absence of any treatment. Piracetam dose-dependently attenuated the memory deficits induced by the three amnesic treatments but did not affect either scopolamine-induced hyperactivity, diazepam-induced release of punished behavior or ECS-induced convulsions. These results point to the specificity of piracetam's anti-amnesic activity and, in particular, suggest that piracetam can suppress the memory disturbances induced by diazepam without affecting diazepam's anxiolytic activity. The test battery employed would therefore seem highly suitable for evaluating the potential nootropic activity of novel compounds.
Lenègre
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I.T.E.M.-Labo, Kremlin-Bicêtre, France.
Chermat
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Avril
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Stéru
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Porsolt
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D000647:Amnesia / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003975:Diazepam / Q000633:toxicity; D004347:Drug Interactions; D004597:Electroshock; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D012601:Scopolamine / Q000633:toxicity
D011760:Pyrrolidinones; D012601:Scopolamine; D003975:Diazepam; D010889:Piracetam