Human immunodeficiency virus-associated disorders in Pakistan.
We have documented evidence of the human immunodeficiency virus (HIV) infection in four individuals including a blood donor and three members of a family (husband, wife, and a child) in Karachi, Pakistan. Our data indicate that HIV has been transmitted to the wife of the seropositive male, a drug abuser, in the recent past and that she has passed the virus to her newborn child perinatally/transplacentally. The two seropositive males (blood donor and drug abuser) were diagnosed clinically as having persistent generalized lymphadenopathy, an AIDS-related condition (ARC), and the child presented with developmental disorders and neurologic manifestations. This is the first report of AIDS/ARC cases from Pakistan that can be directly related to HIV infection and its heterosexual transmission.
Khanani
R M
RM
Department of Microbiology, Jinnah Postgraduate Medical Center, Karachi, Pakistan.
Hafeez
A
A
Rab
S M
SM
Rasheed
S
S
D000386:AIDS-Related Complex / Q000453:epidemiology* / Q000276:immunology; D000328:Adult; D005260:Female; D006679:HIV Seropositivity / Q000150:complications / Q000453:epidemiology* / Q000276:immunology / Q000635:transmission; D006801:Humans; D007223:Infant; D008297:Male; D010154:Pakistan; D012307:Risk Factors; D012882:Skin Tests