title: Effect of copper coordination complexes on sister-chromatid exchanges in plant cells.
abstract: The effectiveness of several copper coordination complexes in the induction of sister-chromatid exchanges (SCE) in meristematic cells of Allium cepa roots was studied. A significant increase in the frequencies of SCE was observed when cells were exposed to different concentrations of copper complexes for 3 h. This effect, which is concentration dependent, seems to be related to the possibility of intercalative binding modes between the planar copper complexes and DNA.
authors: Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.
authors: M J
authors: MJ
authors: Hazen
authors: A
authors: A
authors: Juarranz
authors: J C
authors: JC
authors: Stockert
authors: A
authors: A
authors: González
authors: D
authors: D
authors: Beltrán-Porter
mesh_terms: D000490:Allium / Q000187:drug effects / Q000235:genetics; D003300:Copper / Q000494:pharmacology*; D004249:DNA Damage; D007364:Intercalating Agents / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D007364:Intercalating Agents; D003300:Copper