title: Recovery of cutaneous immune responsiveness after PUVA therapy.
abstract: We studied sensitization to dinitrochlorobenzene (DNCB) in psoriatic patients before, during and 2, 4, and 6 weeks after a course of photochemotherapy (PUVA). The inhibition of sensitivity observed during PUVA was completely reversed after 6 weeks. Thus the PUVA-mediated inhibition of cutaneous immune responsiveness is of short duration. However, whether there are long-term sequelae remains to be established.
authors: Department of Dermatology, University of Newcastle upon Tyne, U.K.
authors: S I
authors: SI
authors: White
authors: P S
authors: PS
authors: Friedmann
authors: C
authors: C
authors: Moss
authors: J M
authors: JM
authors: Simpson
mesh_terms: D004137:Dinitrochlorobenzene / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed; D007114:Immunization; D008297:Male; D011701:PUVA Therapy; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology; D012867:Skin / Q000276:immunology*; D013997:Time Factors
chemical_list: D004137:Dinitrochlorobenzene