Effect of frusemide on urinary kallikrein excretion in the conscious rat: influence of adrenalectomy and DOCA treatment.
The effect of subcutaneous frusemide administration on urinary kallikrein excretion was studied in the conscious state, in control, adrenalectomized and DOCA-treated adrenalectomized rats. Frusemide increased urinary kallikrein excretion in the three groups of rats. Urine volume and urinary sodium and potassium excretions were also increased. These responses were however suppressed by adrenalectomy but normalized by DOCA treatment. It is concluded that frusemide's stimulation of urinary kallikrein excretion in the conscious rat is modulated by mineralocorticoid activity.
Obika
L F
LF
Department of Physiology and Biochemistry, University of Ilorin, Nigeria.
Amurawaiye
B S
BS
Etok-Akpan
E
E
Oduleye
S O
SO
D000315:Adrenalectomy; D000818:Animals; D003900:Desoxycorticosterone / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology*; D007610:Kallikreins / Q000652:urine*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003900:Desoxycorticosterone; D005665:Furosemide; D007610:Kallikreins