title: Comparison between serum isonicotinic acid hydrazide (INH) levels and urinary sulfadimidine (sulfamethazine) acetylation as predictors of INH acetylator status.
abstract: The acetylator status of 40 children with pulmonary tuberculosis was investigated by (1) sulfadimidine (SDM; sulfamethazine) acetylation test in urine and (2) estimation of isonicotinic acid hydrazide (INH) levels. The antimode was at 70% based on the frequency distribution of SDM acetylation. Children acetylating less than 70% of administered SDM were taken as slow acetylators while those with more than 70% as rapid acetylators. The serum INH antimode was at 0.85 micrograms/ml. Thus serum values less than 0.85 micrograms/ml categorised a child as rapid and those with more than 0.85 micrograms/ml as slow acetylators. The sensitivity of these two methods was similar with a correlation coefficient r = 0.64. Thus the determination of the type of acetylator by SDM acetylation test is equally reliable and technically simpler and is recommended instead of INH serum concentration.
authors: Department of Pediatrics, All India Institute of Medical Sciences, New Delhi.
authors: V
authors: V
authors: Seth
authors: S D
authors: SD
authors: Seth
authors: A
authors: A
authors: Beotra
authors: U
authors: U
authors: Singh
mesh_terms: D000107:Acetylation; D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism*; D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007538:Isoniazid / Q000097:blood*; D009748:Nutrition Disorders / Q000201:enzymology; D010641:Phenotype; D013418:Sulfamethazine / Q000652:urine*; D014397:Tuberculosis, Pulmonary / Q000201:enzymology*
chemical_list: D013418:Sulfamethazine; D000123:Acetyltransferases; D007538:Isoniazid