Metabolism of 14C-rhein and 14C-rhein anthrone in rats.
The two radioactive compounds were administered intracaecally to rats, and the recovery rates amounted to 89.9% for 14C-rhein and to 97.4% for 14C-rhein anthrone after 5 days. All organs and tissues showed for both compounds a significant clearance of radioactivity with exception of the kidneys where high levels persisted even after 5 days. Different metabolites could be detected in urine as well as in faeces where also nonanthraquinone fractions could be found.
de Witte
P
P
Laboratorie voor Farmaceutische Biologie en Fytofarmacologie, Katholieke Universiteit, Leuven, Belgium.
Lemli
J
J
D000818:Animals; D000873:Anthracenes / Q000378:metabolism* / Q000493:pharmacokinetics; D000880:Anthraquinones / Q000378:metabolism* / Q000493:pharmacokinetics; D002400:Cathartics / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D000095322:Anthrones
D000873:Anthracenes; D000880:Anthraquinones; D002400:Cathartics; C055876:rhein-9-anthrone; D000095322:Anthrones; C020491:rhein