Differential mechanisms of feeding modulation induced by amino sugars in rats.
The present study examined and compared the effects of N-acetylglucosamine and 1-deoxy-N-acetylglucosamine on feeding behavior with those of glucosamine and 1-deoxyglucosamine. Infusion of 12 mu mole N-acetylglucosamine and 24 mu mole 1-deoxy-N-acetylglucosamine into the rat third cerebroventricle did not affect the feeding behavior. However, oral administration of 1200 mumol N-acetylglucosamine elicited feeding and 2400 mumol 1-deoxy-N-acetylglucosamine markedly suppressed feeding. These effects were abolished by truncal vagotomy. Both glucosamine and 1-deoxyglucosamine affected feeding by intra-third cerebroventricular and oral administration. These findings indicate that N-acetyl amino sugars modulate feeding behavior peripherally through the vagal afferent nerve.
Okabe
Y
Y
Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Sakata
T
T
Fujimoto
K
K
Kurata
K
K
Yoshimatsu
H
H
Ueda
K
K
D000117:Acetylglucosamine / Q000008:administration & dosage / Q000494:pharmacology*; D000284:Administration, Oral; D000818:Animals; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D005944:Glucosamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014628:Vagotomy
C047200:1-deoxyglucosamine; D005944:Glucosamine; D000117:Acetylglucosamine