[Participation of the adenine nucleotide translocator in the regulation of pyruvate oxidation in heart mitochondria].
A regulatory role of adenine nucleotide translocator (ANT) was determined by titration of mitochondrial respiration (state 3) with carboxyatractyloside. It was shown that ANT regulates pyruvate oxidation: the control strength is more pronounced after depletion of endogenous substrates or after the increase in extramitochondrial ATP/ADP. The rate of succinate oxidation is controlled mainly by succinate dehydrogenase, while ANT does not participate in its regulation.
Ivanovene
L I
LI
Borutaĭte
V I
VI
Zhilinskene
V Iu
VIu
Toleĭkis
A I
AI
Prashkiavichius
A K
AK
D000227:Adenine Nucleotides / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001278:Atractyloside / Q000031:analogs & derivatives / Q000032:analysis; D008929:Mitochondria, Heart / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D011773:Pyruvates / Q000378:metabolism*; D011817:Rabbits; D013385:Succinate Dehydrogenase / Q000378:metabolism
D000227:Adenine Nucleotides; D011773:Pyruvates; D001278:Atractyloside; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D013385:Succinate Dehydrogenase; C003853:carboxyatractyloside
Uchastie perenoschika adeninnukleotidov v reguliatsii okisleniia piruvata v mitokhondriiakh serdtsa.