Sucralfate inhibition of tumor cell implantation in the murine urinary bladder.
Superficial transitional cell carcinoma of the bladder has a 50 to 70% recurrence rate. Recurrences may be related to tumor cell implantation during transurethral resection which disrupts the glycosaminoglycan layer of the bladder. This study demonstrated decreased tumor formation in murine bladders which were pre-treated with sucralfate, a synthetic glycosaminoglycan, prior to tumor cell instillation. These results suggest a possible role for sucralfate as a glycosaminoglycan supplement.
Van Every
M J
MJ
Department of Urology, Wilford Hall United States Air Force Medical Center, Lackland AFB, Texas.
Sago
A L
AL
Ehler
W J
WJ
Novicki
D E
DE
D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D011292:Premedication; D013392:Sucralfate / Q000494:pharmacology*; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000517:prevention & control*
D013392:Sucralfate