The oxidant defence system in water-buffaloes (Bubalus bubalis) experimentally infected with Anaplasma marginale.
The glutathione (GSH) -oxidant defence system protects the erythrocytes and leucocytes from oxidative damage. Leucocyte -superoxide dismutase (SOD), GSH-peroxidase (GSH-px), GSH-reductase (GR), GSH-S-transferase (GSH-S-t) and arginase were examined in samples from buffaloes infected with Anaplasma marginale. All the enzymes, except arginase, were also studied in the red cell haemolysates from these animals. GSH-S-t, GSH- and glutathione-reductase (GR) levels in leucocytes decreased in infected animals suggesting a decline in the efficiency of the GSH-oxidant defence system. SOD levels increased but there was no change in leucocyte-arginase activity due to infection. Infection caused no significant changes in red cell SOD, GSH-px, GR and GSH. However, GSH-S-t significantly decreased (P less than 0.05).
Reddy
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GR
Division of Biochemistry and Food Science, Indian Veterinary Research Institute, Izatnagar.
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Sharma
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Singh
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D000712:Anaplasmosis / Q000097:blood* / Q000201:enzymology / Q000276:immunology; D000818:Animals; D001119:Arginase / Q000097:blood; D002020:Buffaloes; D004912:Erythrocytes / Q000201:enzymology*; D005978:Glutathione / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D007962:Leukocytes / Q000201:enzymology*; D008297:Male; D010084:Oxidation-Reduction; D013482:Superoxide Dismutase / Q000097:blood
D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D001119:Arginase; D005978:Glutathione