Inheritance of diabetes mellitus in Keeshond dogs.
The genetic aspects of inherited, insulin-dependent diabetes mellitus of Keeshond dogs were studied retrospectively and in a prospective mating program. The symbol dm was used to designate the gene that causes hypoplasia of the islets of Langerhans. The retrospective study disclosed 4 diabetic dogs; prospective outcross, backcross, and inbred matings disclosed 49 diabetic dogs. Outcrossing demonstrated that the diabetic phenotype was displayed readily against a genetic background of a breed other than the Keeshond. In dogs with the dm/dm genotype, onset of diabetes was most frequent before the dog was 6 months old, but did occur in some older dogs. The dm genotype was best described as autosomal recessive.
Kramer
J W
JW
College of Veterinary Medicine, Washington State University, Pullman 99164.
Klaassen
J K
JK
Baskin
D G
DG
Prieur
D J
DJ
Rantanen
N W
NW
Robinette
J D
JD
Graber
W R
WR
Rashti
L
L
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000662:veterinary*; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D005838:Genotype; D008297:Male; D010375:Pedigree; D011446:Prospective Studies; D012189:Retrospective Studies