title: Sensory deafferentation fails to modify muscarinic receptor binding in raccoon somatosensory cortex.
abstract: The characteristics and distribution of muscarinic acetylcholine (mACh) receptor binding in primary somatosensory (SI) cortex and the caudate nucleus of raccoons were studied using [3H]-QNB, a muscarinic antagonist. The binding characteristics were similar to reported values in rat and cat. Autoradiographs produced from tissue sections labeled with [3H]-QNB showed the distribution of mACh receptors in the forebrain of the raccoon. [3H]-QNB binding was highest in cerebral cortex, neostriatum and hippocampus. Within SI cortex, binding was high in layers I-III and VI and relatively low in layers IV and V. Autoradiographs obtained from animals that had undergone peripheral deafferentation of part of the forepaw revealed no changes in [3H]-QNB binding in the affected cortical region during the time that physiological reorganization is known to occur.
authors: Department of Physiology and Biophysics, Dalhousie University, Halifax, N.S., Canada.
authors: S M
authors: SM
authors: Sampson
authors: C
authors: C
authors: Shaw
authors: M
authors: M
authors: Wilkinson
authors: D D
authors: DD
authors: Rasmusson
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001285:Atropine / Q000378:metabolism; D001345:Autoradiography; D002421:Caudate Nucleus / Q000378:metabolism; D009475:Neurons, Afferent / Q000378:metabolism*; D010525:Peripheral Nerves / Q000502:physiology; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D011821:Raccoons / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism*; D013003:Somatosensory Cortex / Q000378:metabolism* / Q000502:physiology
chemical_list: D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate; D001285:Atropine