title: Tuberculosis presenting as laryngeal stridor in a child.
abstract: A three and a half-year-old boy developed stridor after insertion of grommets for bilateral secretory otitis media. Despite treatment with steroids systemically and locally, antibiotics and an antihistamine, the stridor worsened. Microlaryngotracheobronchoscopy (MLB) demonstrated laryngeal granulations, in which, by auramine and Ziehl-Neelsen staining, acid-fast bacilli were seen, and from which subsequently Mycobacterium tuberculosis grew in culture. Following the MLB the child became comatosed and a clinical diagnosis of tuberculosis involving the central nervous system was made. Despite quadruple antituberculous chemotherapy he died 8 days later. A Mantoux test was negative and a chest radiograph was normal. Acid-fast bacilli were not demonstrated on repeated examinations of cerebrospinal fluid, nor were they grown ante mortem or post mortem from samples of cerebrospinal fluid.
authors: Hospital for Sick Children, London, U.K.
authors: A C
authors: AC
authors: Elias-Jones
authors: J
authors: J
authors: Sequeira
authors: R N
authors: RN
authors: Leitch
authors: S R
authors: SR
authors: Heard
mesh_terms: D002675:Child, Preschool; D006801:Humans; D007273:Injections, Intramuscular; D007278:Injections, Spinal; D007538:Isoniazid / Q000627:therapeutic use; D007830:Larynx / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D011718:Pyrazinamide / Q000627:therapeutic use; D012135:Respiratory Sounds / Q000209:etiology*; D012293:Rifampin / Q000627:therapeutic use; D013307:Streptomycin / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014387:Tuberculosis, Laryngeal / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014391:Tuberculosis, Miliary / Q000175:diagnosis* / Q000473:pathology
chemical_list: D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin