[Schoenlein-Henoch purpura in chronic HBsAG-positive hepatitis].
We report about a 40-year-old male patient suffering from a recurrent vasculitis with purpura since the age of 18. In 1983, a HBsAg-positive chronic active hepatitis with circulating immune complexes which contained HBsAg, immunoglobulin M and G as well as complement (C) was diagnosed. Serum and liver tissue were negative for HBcAg, HBeAg and hepatitis B virus (HBV) DNA; there was no evidence for HBV replication. HBsAg, IgM and C3 were demonstrable in the arteriolar walls of the skin. The results support the concept that complement activating immune complexes containing HBsAg and IgM anti HBs play a role in the pathogenesis of vasculitis as described here.
Stemerowicz
R
R
Klinikum Charlottenburg der Freien, Universität Berlin, Medizinische Klinik und Poliklinik.
Möller
B
B
Lobeck
H
H
Oertel
J
J
Hopf
U
U
D000328:Adult; D002908:Chronic Disease; D003165:Complement System Proteins / Q000032:analysis; D006509:Hepatitis B / Q000150:complications* / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis; D008297:Male
D006514:Hepatitis B Surface Antigens; D007136:Immunoglobulins; D003165:Complement System Proteins
Schoenlein-Henoch-Purpura bei HBsAg-positiver chronischer Hepatitis.