Human sperm chromosome studies in a reciprocal translocation t(2;5).
Sperm chromosome complements have been studied in a man heterozygous for a reciprocal translocation t(2;5)(p11;q15). Human sperm chromosomes were obtained after fertilization of zona-free hamster eggs. A total of 75 human sperm metaphases were analysed. On the complements studied, 59 (78.6%) resulted from a 2:2 segregation and 16 (21.3%) from a 3:1 segregation, 4:0 segregation was not observed. Our results indicate that at least 36% of sperm complements were unbalanced with respect to the translocation. The frequency of other chromosome anomalies unrelated to the translocation was 16%.
Templado
C
C
Instituto de Biología Fundamental V. Villar Palasí, Bellaterra, Barcelona, Spain.
Navarro
J
J
Benet
J
J
Genescà
A
A
Pérez
M M
MM
Egozcue
J
J
D000328:Adult; D002871:Chromosome Banding; D002889:Chromosomes, Human, Pair 2; D002895:Chromosomes, Human, Pair 5; D006579:Heterozygote; D006801:Humans; D007621:Karyotyping; D008297:Male; D013094:Spermatozoa / Q000648:ultrastructure*; D014178:Translocation, Genetic