Measures of and tests for net improvement in clinical trials, PhD.
For clinical trials in which the outcome variable is trichotomous (regression, no change, improvement), a measure of net improvement in health status is proposed. Test statistics are derived for the null hypothesis of zero net improvement in a single patient group and for the null hypothesis of no difference in net improvement between two groups. The methods are applied to a clinical trial that evaluated the effect of argon laser photocoagulation in patients with macular edema in branch vein occlusion.
Kimball
A W
AW
Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205.
D002986:Clinical Trials as Topic / Q000592:standards*; D006304:Health Status; D006801:Humans; D012107:Research Design; D013223:Statistics as Topic; D014481:United States; D014792:Visual Acuity