Cellular migration in developing cerebral wall explants in vitro.
Explants of the developing cerebral wall of the embryonic mouse survive in rotation-mediated culture for at least 3 days. [3H]Thymidine-labeled cells are initially located in the ventricular zone but after two days in vitro are located in a middle cell-rich layer. Cortical explants can thus be used as a model system in which the molecular mechanisms of neuronal migration in the developing cerebral wall can be examined.
Hemmendinger
L M
LM
Southard Laboratory of Neuropathology, E.K. Shriver Center, Waltham, MA 02254.
Caviness
V S
VS
D000818:Animals; D002455:Cell Division; D002465:Cell Movement; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D004847:Epithelial Cells; D004848:Epithelium / Q000196:embryology / Q000502:physiology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology; D013936:Thymidine
D013936:Thymidine