Effect of copper coordination complexes on sister-chromatid exchanges in plant cells.
The effectiveness of several copper coordination complexes in the induction of sister-chromatid exchanges (SCE) in meristematic cells of Allium cepa roots was studied. A significant increase in the frequencies of SCE was observed when cells were exposed to different concentrations of copper complexes for 3 h. This effect, which is concentration dependent, seems to be related to the possibility of intercalative binding modes between the planar copper complexes and DNA.
Hazen
M J
MJ
Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.
Juarranz
A
A
Stockert
J C
JC
González
A
A
Beltrán-Porter
D
D
D000490:Allium / Q000187:drug effects / Q000235:genetics; D003300:Copper / Q000494:pharmacology*; D004249:DNA Damage; D007364:Intercalating Agents / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013329:Structure-Activity Relationship
D007364:Intercalating Agents; D003300:Copper