Serum concentrations of trypsin-like immunoreactivity and pancreatic isoamylase in insulin dependent diabetic patients.
Serum trypsin-like immunoreactivity and pancreatic isoamylase were measured in 302 insulin-dependent diabetic patients (166 men) using radioimmunoassay for the former and a photocolorimetric method for the latter. There was a significant correlation between the two enzymes (r = 0.67, p less than 0.0001) with lower concentrations of both trypsin-like immunoreactivity (208.8 micrograms/L) and pancreatic isoamylase (67.5 U/L) in diabetic patients as compared to controls (p less than 0.0001). Using multiple regression analysis, a statistically significant association was only apparent between enzyme concentrations and age at onset of diabetes (r = 0.31, p less than 0.0001). The results suggest that impaired exocrine pancreatic function may occur in an appreciable proportion of diabetic patients and also that a primary insult to the exocrine pancreas occurring at the time of endocrine injury may be a contributory factor.
Moles
K W
KW
Department of Medicine, Queen's University of Belfast, Northern Ireland.
Kerr
J I
JI
Armstrong
E
E
Hayes
J R
JR
Buchanan
K D
KD
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000201:enzymology*; D005260:Female; D006026:Glycoside Hydrolases / Q000097:blood*; D006801:Humans; D007517:Isoamylase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology*; D012737:Sex Factors; D014357:Trypsin / Q000097:blood* / Q000276:immunology
D006026:Glycoside Hydrolases; D007517:Isoamylase; D014357:Trypsin