Congenital osteochondrodysplasia with systemic subcutaneous edema (ocd/ocd): a new lethal autosomal recessive mutant of the rat.
The inheritance of a new lethal mutant rate showing congenital osteochondrodysplasia with systemic subcutaneous edema (ocd for the gene symbol) was examined by crossings between the carriers and between F1s derived from the carrier x Long-Evans crossing. The ratio of the affected to phenotypically normal was 276:89 in pups derived from the crossings between the carriers and 83:17 in those at the LE-F2 generation derived from the proven carriers of the LE-F1 animals, thus showing that the ratio is 3:1. The female:male ratio was 47:42 in the affected and 133:143 in the phenotypically normal pups, showing the sex ratio is 1:1, irrespective of the affected or phenotypically normal. The ratio of affected:carrier:noncarrier was 26:58:27 in littermates derived from the crossings between the carriers, showing the ratio is 1:2:1. The results fitted well to the hypothesis that the inheritance is a single autosomal recessive trait. Independence of the gene from linkage group I was also revealed, because the ratio of colored to albino was 14:3 and 65:18 in affected and phenotypically normal pups at the LE-F2 generation, respectively, which fitted to the ratio of 3:1.
Suzuki
K
K
Department of Veterinary Physiology, Nippon Veterinary and Zootechnical College, Tokyo, Japan.
Kikukawa
K
K
Hakamata
Y
Y
Kamei
T
T
Imamichi
T
T
D000818:Animals; D003433:Crosses, Genetic; D004194:Disease; D004487:Edema / Q000150:complications / Q000235:genetics*; D005260:Female; D005804:Genes, Lethal; D005808:Genes, Recessive; D006580:Genetic Carrier Screening; D008297:Male; D009154:Mutation; D010009:Osteochondrodysplasias / Q000150:complications / Q000151:congenital / Q000235:genetics*; D010641:Phenotype; D051381:Rats; D011922:Rats, Mutant Strains