title: Analysis of duration of response: a problem of oncology trials.
abstract: Comparing response durations between treatment groups in a randomized clinical trial can be inappropriate and give misleading results concerning the relative durability of responses. Due to patient variability, the treatment producing more responses will usually also have responsive patients of poorer prognosis. A treatment that increases the probability and duration of a response can appear to produce responses of shorter duration based on an analysis of duration of response. Alternative procedures are discussed.
authors: Oncology Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
authors: T M
authors: TM
authors: Morgan
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D011897:Random Allocation; D012107:Research Design; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents