In vitro transformation of cheno- and ursodeoxycholic acids and their 7-oleyl esters by human intestinal microflora.
Chenodeoxycholic and ursodeoxycholic acid are used widely for the treatment of gallstones. A possible drawback to their utility is their conversion to lithocholic acid, which has displayed histotoxicity and mutagenicity. The 7-oleyl esters of cheno- and ursodeoxycholic acid are not degraded by fecal bacteria and may represent safer means of treatment.
Ferrari
A
A
Department of Food Science and Microbiology, University of Milan, Italy.
Pacini
N
N
Sirtori
C R
CR
Kritchevsky
D
D
D001711:Biotransformation; D002635:Chenodeoxycholic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D003840:Deoxycholic Acid / Q000031:analogs & derivatives*; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008095:Lithocholic Acid / Q000378:metabolism; D019301:Oleic Acid; D009829:Oleic Acids; D013329:Structure-Activity Relationship; D014580:Ursodeoxycholic Acid / Q000031:analogs & derivatives* / Q000378:metabolism
D009829:Oleic Acids; D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; D019301:Oleic Acid; D008095:Lithocholic Acid; D014580:Ursodeoxycholic Acid