[Activity of natural killers in acute leukemia in children].
Natural killer (NK) activity was studied in healthy children, (16) and those with acute leukemia at different phases of the disease (63). Patients' age ranged 3-11 years. NK activity was measured by release of 51Cr from the labelled K 562 target cells. A sharp decrease in NK activity was found in the acute phase, irrespective of the morphologic pattern of acute leukemia, the degree of blastosis and therapy. 75% of patients achieving remission revealed a decreased NK activity within the first 24 months, while in 25% it was normal. At 3 years and later, the majority of responders showed normal NK activity.
Blinov
M N
MN
Vartanian
N L
NL
Luganova
I S
IS
Klubovskaia
N I
NI
Alekseev
N A
NA
D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D007938:Leukemia / Q000276:immunology*
Aktivnost' estestvennykh killerov pri ostrom leĭkoze u deteĭ.