Laminin and type III procollagen peptide in human preovulatory follicular fluid.
The levels of laminin P1 fragment, a marker of basement membrane, and of the aminoterminal sequence of type III procollagen, a marker of interstitial connective tissue, were measured in human preovulatory follicular fluids. The concentrations of these peptides correlated with progesterone levels but not with those of estradiol or testosterone. Immunocytochemical studies confirmed the remodeling of the perifollicular basement membrane and interstitial matrix during oocyte maturation. The studies suggest that monitoring of the ovarian connective tissue macromolecules could be useful for estimating follicular maturation.
Christiane
Y
Y
University of Liege, Belgium.
Demoulin
A
A
Gillain
D
D
Leroy
F
F
Lambotte
R
R
Lapiere
C M
CM
Nusgens
B
B
Foidart
J M
JM
D001485:Basement Membrane / Q000032:analysis; D005260:Female; D006801:Humans; D007797:Laminin / Q000032:analysis*; D006080:Ovarian Follicle / Q000032:analysis* / Q000166:cytology; D010060:Ovulation; D010446:Peptide Fragments / Q000032:analysis*; D011347:Procollagen / Q000032:analysis*
D007797:Laminin; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide