Toxicity of chronic high alcohol intake on mouse natural killer cell activity.
The toxicity of chronic alcohol intake on natural killer (NK) cell activity of spleen cells from well-nourished, female C57BL/6 mice was studied in a 4-hour cytolytic chromium-release assay against YAC-1 lymphoma cells. Mice were fed a nutritionally complete crystalline amino acid diet and received 20% w/v alcohol solution for 12 weeks. Ad libitum and pair-fed control mice were given diet and either an isocaloric glucose solution or water. Decreased NK cell activity was observed in alcohol-consuming mice relative to all other control groups. NK cell activity was moderately decreased by feeding mice a high glucose diet, but more severely lowered in pair-fed groups compared to ad libitum control groups.
Abdallah
R M
RM
College of Pharmacy and the Pharmacology/Toxicology Program, Washington State University, Pullman 99164-6510.
Starkey
J R
JR
Meadows
G G
GG
D000818:Animals; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL
D000431:Ethanol