title: 5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue.
abstract: The enzymatic release of 5-hydroxymethylcytosine from T2 bacteriophage DNA was effected by an extract of calf thymus. Like the previously described 5-hydroxymethyluracil DNA glycosylase, 5-hydroxymethylcytosine DNA glycosylase was not detectable in bacterial extracts. The phylogenetic distribution of these activities indicates that their primary function is the maintenance of methylcytosine residues in differentiated tissue.
authors: Department of Pathology, New York University School of Medicine, New York, NY 10016.
authors: S V
authors: SV
authors: Cannon
authors: A
authors: A
authors: Cummings
authors: G W
authors: GW
authors: Teebor
mesh_terms: D044503:5-Methylcytosine / Q000031:analogs & derivatives; D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D003596:Cytosine / Q000031:analogs & derivatives* / Q000378:metabolism; D045647:DNA Glycosylases; D004279:DNA, Viral / Q000378:metabolism; D009699:N-Glycosyl Hydrolases / Q000378:metabolism*; D013604:T-Phages / Q000235:genetics; D013950:Thymus Gland / Q000201:enzymology
chemical_list: D004279:DNA, Viral; C011865:5-hydroxymethylcytosine; D044503:5-Methylcytosine; D003596:Cytosine; D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases