Aclacinomycin tissue distribution in the rat.
This study was undertaken to investigate aclacinomycin distribution in the rat, using a method based on the histofluorescence of tissues treated in vivo with anthracyclines. The target organs were the kidney, lung and pancreas; a fainter fluorescence was also detected in the heart compared with adriamycin due to a quantitatively different fixing of the two anthracyclines. Our findings revealed a preferential uptake into the cell nucleus in all tissues examined except the adrenal gland medulla where a slight fluorescence appeared only in the cytoplasm.
Mazzanti
L
L
Institute of Pharmacology, School of Medicine, University of Pisa, Italy.
Scalori
V
V
Mian
M
M
Alessandrì
M G
MG
Giovannini
L
L
D015250:Aclarubicin / Q000031:analogs & derivatives*; D000313:Adrenal Medulla / Q000032:analysis; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics*; D002467:Cell Nucleus / Q000032:analysis; D007668:Kidney / Q000032:analysis; D008168:Lung / Q000032:analysis; D008297:Male; D009279:Naphthacenes / Q000493:pharmacokinetics; D010179:Pancreas / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013050:Spectrometry, Fluorescence; D014018:Tissue Distribution
D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; C011157:aclacinomycins; D015250:Aclarubicin