Utilization of the quantitative component of positive and negative results of short-term tests.
In this paper we discuss the possibility of utilizing not only the qualitative component of the information obtained from long-term and short-term tests (as is customary), but also the quantitative component of the results. We suggest that there is probably a precise mathematical relationship between the qualitative and quantitative approaches. We show that utilizing the quantitative approach, it is possible to give confidence limits to a given prediction, a possibility potentially very useful for risk evaluation. We show that starting from a reasonable working hypothesis, it is possible to include even negative data in a unified quantitative approach. Incorporating the quantitative component of the information could offer appreciable gains in predictivity, especially when utilizing batteries of tests.
Parodi
S
S
Department of Clinical and Experimental Oncology, University of Genoa/Istituto Nazionale per la Ricerca sul Cancro, Italy.
Taningher
M
M
Santi
L
L
D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D007256:Information Systems; D009152:Mutagenicity Tests / Q000379:methods*; D013223:Statistics as Topic; D013997:Time Factors
D002273:Carcinogens