Risk factors for candidemia in cancer patients: a case-control study.
Risk factors for candidemia were analyzed in a case-control study of 30 cancer patients with candidemia and 58 controls. In a univariate analysis, previous surgery, neutropenia, central catheterization, chemotherapy, specific antibiotic treatments, and peripheral cultures positive for Candida spp. were associated with a significantly increased risk of candidemia. In a multivariate logistic model, the significant risk factors for candidemia were positive peripheral cultures for Candida spp. (P = 0.02), central catheterization (P = 0.03), and neutropenia (P = 0.05). These results should help to identify cancer patients with a high risk of candidemia, who should be given early systemic antifungal therapy.
Karabinis
A
A
Service de Microbiologie Médicale, Institut Gustave-Roussy, Villejuif, France.
Hill
C
C
Leclercq
B
B
Tancrède
C
C
Baume
D
D
Andremont
A
A
D000328:Adult; D002177:Candidiasis / Q000209:etiology*; D002405:Catheterization, Central Venous / Q000009:adverse effects; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications; D008223:Lymphoma / Q000150:complications; D008297:Male; D009369:Neoplasms / Q000150:complications*; D009503:Neutropenia / Q000150:complications; D012307:Risk Factors; D018805:Sepsis / Q000209:etiology*