title: Pharmacokinetics of benperidol in volunteers after oral administration.
abstract: Benperidol in a 4 mg single dose was administered orally to five healthy male volunteers. The drug was rapidly absorbed (tmax = 2.27 +/- 0.57 h) and largely distributed, the volume of distribution being 5.19 +/- 1.99 l.kg-1. Elimination half-life was 7.65 +/- 2.14 h. Urinary excretion represented only a minimal fraction of ingested dose (0.1 +/- 0.007%). Variability of the area under the curve makes a first-pass metabolism a reasonable possibility. Acute dystonias appeared in two subjects.
authors: Department of Pharmacology, University of Padua, Italy.
authors: M
authors: M
authors: Furlanut
authors: P
authors: P
authors: Benetello
authors: A
authors: A
authors: Perosa
authors: G
authors: G
authors: Colombo
authors: F
authors: F
authors: Gallo
authors: A
authors: A
authors: Forgione
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001544:Benperidol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D012016:Reference Values
chemical_list: D001544:Benperidol