title: Gas chromatography/mass spectrometry and gas chromatography/tandem mass spectrometry of methyl ester/methoxime/trimethylsilyl ether derivatives of prostaglandins.
abstract: Electron impact mass spectra of methyl ester/trimethylsilyl ether derivatives of prostaglandin F2 alpha and methyl ester/methoxime/trimethylsilyl ether derivatives of prostaglandin E2, prostaglandin D2, 6-oxo-prostaglandin F1 alpha and 2,3-dinor-6-oxo-prostaglandin F1 alpha are presented. Most of the prostaglandins studied have additionally been 2H-labelled at different sites in order to assign the corresponding fragment ions. Collisionally activated decomposition mass spectra of the most intense parent ions in the high-mass region were taken. High-intensity, prostaglandin-characteristic daughter fragments will allow a reliable quantification of prostaglandins in biological fluids and a reduction of sample clean-up.
authors: Universitätskinderklinik, Heidelberg, FRG.
authors: H
authors: H
authors: Schweer
authors: H W
authors: HW
authors: Seyberth
authors: C O
authors: CO
authors: Meese
mesh_terms: D004952:Esters; D004987:Ethers; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D007202:Indicators and Reagents; D011453:Prostaglandins / Q000032:analysis*
chemical_list: D004952:Esters; D004987:Ethers; D007202:Indicators and Reagents; D011453:Prostaglandins