Oral urea in the treatment of secondary tumours in the liver.
Twenty patients with secondary liver tumours, predominantly from colorectal carcinoma, were treated with oral urea at a daily dose of 8 gm-2. Treatment was well tolerated without side-effects. No objective responses were seen. It is concluded that oral urea is ineffective in the treatment of liver metastases from colorectal cancer.
Clark
P I
PI
Department of Medical Oncology, St. Bartholomew's Hospital, London, UK.
Slevin
M L
ML
Webb
J A
JA
Osborne
R J
RJ
Jones
S
S
Wrigley
P F
PF
D000284:Administration, Oral; D000368:Aged; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D014508:Urea / Q000008:administration & dosage / Q000627:therapeutic use*
D014508:Urea