Effects of oxiracetam-scopolamine combinations on shuttle-box avoidance acquisition in mice.
The nootropic drug oxiracetam and the anticholinergic agent scopolamine were tested, alone or in combination, on shuttle-box avoidance acquisition and locomotor activity in mice of the CD-1 strain. Both drugs, given separately, slightly but significantly enhanced avoidance performance, but only scopolamine increased locomotor activity. Combinations of the 2 drugs, in some instances, enhanced avoidance performance more than drugs given separately, but the disinhibitory property of scopolamine makes it difficult to understand the role played by cholinergic mechanisms in these effects.
Sansone
M
M
Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy.
Libri
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V
Pavone
F
F
Ammassari-Teule
M
M
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D005260:Female; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011759:Pyrrolidines / Q000494:pharmacology*; D012601:Scopolamine / Q000494:pharmacology*
D011759:Pyrrolidines; D012601:Scopolamine; C040619:oxiracetam