A molecular basis for MHC class II--associated autoimmunity.
Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus-derived lymphocytes (T cells). Nucleotide sequence polymorphism in the genes that encode the class II MHC products determines the specificity of the immune response and is correlated with the development of autoimmune diseases. This study identifies certain class II polymorphic amino acid residues that are strongly associated with susceptibility to insulin-dependent diabetes mellitus, rheumatoid arthritis, and pemphigus vulgaris. These findings implicate particular class II MHC isotypes in susceptibility to each disease and suggest new prophylactic and therapeutic strategies.
Todd
J A
JA
Department of Medical Microbiology, Stanford University, CA 94305.
Acha-Orbea
H
H
Bell
J I
JI
Chao
N
N
Fronek
Z
Z
Jacob
C O
CO
McDermott
M
M
Sinha
A A
AA
Timmerman
L
L
Steinman
L
L
D000595:Amino Acid Sequence; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001323:Autoantibodies / Q000235:genetics*; D001327:Autoimmune Diseases / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D006681:HLA-D Antigens / Q000235:genetics*; D006801:Humans; D008285:Major Histocompatibility Complex; D008969:Molecular Sequence Data; D010392:Pemphigus / Q000276:immunology
D001323:Autoantibodies; D006681:HLA-D Antigens