Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein.
The S- and F-forms of alpha-1 acid glycoprotein (AAG) variants have been isolated by isoelectric focusing with immobilines from commercially available AAG. In equilibrium dialysis experiments using a multicompartmental system, a higher affinity for various basic drugs has been found with S- in comparison with F-AAG: Amitriptyline, nortriptyline, imipramine, desipramine, trimipramine, methadone, thioridazine, clomipramine, desmethylclomipramine, and maprotiline. The selectivity (binding to S- vs. F-AAG) is the most pronounced for methadone and the lowest for thioridazine, while it is absent for the acidic drug mephenytoin.
Eap
C B
CB
Clinique Psychiatrique Universitaire de Lausanne, Hôpital de Cery, Prilly, Switzerland.
Cuendet
C
C
Baumann
P
P
D000639:Amitriptyline / Q000378:metabolism; D002997:Clomipramine / Q000378:metabolism; D003891:Desipramine / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007099:Imipramine / Q000378:metabolism; D008376:Maprotiline / Q000378:metabolism; D008691:Methadone / Q000378:metabolism; D009961:Orosomucoid / Q000031:analogs & derivatives / Q000378:metabolism*; D011619:Psychotropic Drugs / Q000378:metabolism*; D013881:Thioridazine / Q000378:metabolism; D014299:Trimipramine / Q000378:metabolism
D009961:Orosomucoid; D011619:Psychotropic Drugs; D000639:Amitriptyline; D008376:Maprotiline; D014299:Trimipramine; D013881:Thioridazine; D002997:Clomipramine; D007099:Imipramine; D003891:Desipramine; D008691:Methadone