title: [Neurophysiological and therapeutic evaluation of stiripentol in epilepsy. Preliminary results].
abstract: The main objective of this study was to determine whether stripentol (STP) alleviates side-effects commonly observed in treated epileptic patients, since preliminary data suggested a positive psychotropic effect. A secondary objective was an evaluation of drug efficacy. Eleven patients with either a drug-resistant epilepsy or toxic effects of AEDs completed the study. Ten had symptomatic partial epilepsies and one an idiopathic generalized epilepsy. STP was added to the baseline therapy (1 or 2 AEDs) and the dose of the baseline AEDs was reduced to maintain plasma levels unchanged (mean reduction: PB 26%, PHT: 49%, CBZ: 38%). Several motor, perceptual and attention tasks and the Washington Psychosocial Seizure Inventory were performed before and after STP administration. Seizure frequency and clinical side-effects were evaluated during a baseline period and after two months of constant therapy. Effects of repeated administration of the neuropsychological battery were assessed by administration of the battery on two occasions at 12-week interval to a randomized subgroup of patients. No practice effect was observed. A trend of improvement (p less than 0.05) in the performance of two tasks requiring sustained attention was noted. Previous side-effects (mainly drowsiness) decreased or disappeared in 7 of 9 patients who became more alert. Six of the nine uncontrolled patients experienced a decrease in seizure frequency equal to or larger than 50 per cent.
authors: Service de Neurologie, C.H.U. Bordeaux, Hôpital Pellegrin.
authors: P
authors: P
authors: Loiseau
authors: E
authors: E
authors: Strube
authors: J
authors: J
authors: Tor
authors: R H
authors: RH
authors: Levy
authors: C
authors: C
authors: Dodrill
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D004148:Dioxolanes / Q000009:adverse effects / Q000627:therapeutic use*; D004149:Dioxoles / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011619:Psychotropic Drugs / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D004148:Dioxolanes; D004149:Dioxoles; D011619:Psychotropic Drugs; C021092:stiripentol
vernacular_title: Evaluation neuropsychologique et thérapeutique du stiripentol dans l'épilepsie.