The protective effect of Meciadanol (O-methyl-3(+)-catechin) on experimental ulceration.
Meciadanol, (O-methyl-3(+)-catechin), a histidine decarboxylase inhibitor was shown to have a marked protective action against experimental peptic ulceration in three rat models. The three methods used to induce ulceration were the instillation of absolute alcohol, pyloric ligation following an ulcerogenic South Indian diet and the instillation of rice bran oil into the stomach after pyloric ligation. Meciadanol was shown to reduce incidence, numbers and areas of ulceration and protected mast cells against degranulation and to preserve a normal vascular patterns. Furthermore, Meciadanol reduced gastric acid output and concentration in the pylorus ligation model. These results indicate that Meciadanol may be useful for the treatment of peptic ulcers in humans.
Jayaraj
A P
AP
Department of Surgery, University College London, U.K.
Lewin
M R
MR
Tovey
F I
FI
Kitler
M E
ME
Clark
C G
CG
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002392:Catechin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003594:Cytoplasmic Granules / Q000187:drug effects; D004032:Diet; D000431:Ethanol; D005260:Female; D008407:Mast Cells / Q000187:drug effects; D008833:Microcirculation / Q000187:drug effects; D009821:Oils; D011708:Pylorus / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D009821:Oils; C029339:meciadanol; D000431:Ethanol; D002392:Catechin