Modification of the hypoxic fraction of a xenografted human colon tumor by differentiation-inducing agents.
Xenografted tumors were produced in nude mice by injection of HCT-15 human colon tumor cells. The hypoxic fractions of control tumors as determined from x-ray survival curves were approximately 18%. Other tumors were treated (every day X 9) with daily injections of N-methylformamide (150 mg/kg) or sodium butyrate (2,000 mg/kg). For both agents, it was found that the hypoxic fractions were less than 0.05% and less than 1.7%, respectively. These data indicate that selected differentiation-inducing agents could be of value for treatment of human solid tumors that contain hypoxic cells.
Leith
J T
JT
Department of Radiation Medicine and Biology Research, Rhode Island Hospital, Providence.
D000818:Animals; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D002454:Cell Differentiation / Q000187:drug effects*; D002470:Cell Survival / Q000528:radiation effects; D003110:Colonic Neoplasms / Q000473:pathology*; D005260:Female; D005559:Formamides / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D010100:Oxygen; D014183:Transplantation, Heterologous
D002087:Butyrates; D005559:Formamides; D020148:Butyric Acid; D010100:Oxygen; C002950:methylformamide