[Phospholipids as emulsifiers in fat emulsions--effect on phospholipids in the serum lipoprotein fraction d greater than 1.063].
Fat emulsions for parenteral nutrition contain phospholipids of different quantity and quality. They are substrates of lecithin-cholesterol-acyltransferase (LCAT). Two fat emulsions commonly used in parenteral nutrition with different emulsifiers (Intralipid 10%, emulsified with egg phospholipid, and Lipofundin S 10%, emulsified with soya phospholipid) were infused into six healthy volunteers. The products of the LCAT reaction were determined in serum lipoprotein fraction d greater than 1.063. Lecithin (16%) as well as lysolecithin (30%) increased by the same amount during a 4-h infusion of each fat emulsion. The concentrations of lecithin and lysolecithin were still within normal ranges after infusion. The percentage of linoleic acid in cholesterol esters in d greater than 1.063 fraction remained unchanged during infusion of soya phospholipids and decreased 5% during infusion of egg phospholipids. The results indicate an equal LCAT activation by both fat emulsions in man.
Hailer
S
S
Institut für Ernährungswissenschaft, Technischen Universität, München, Freising-Weihenstephan.
Kalb
S
S
Wolfram
G
G
D000328:Adult; D002788:Cholesterol Esters / Q000097:blood; D005079:Excipients; D005217:Fat Emulsions, Intravenous; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood; D010743:Phospholipids / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D002788:Cholesterol Esters; D005079:Excipients; D005217:Fat Emulsions, Intravenous; D008074:Lipoproteins; D010743:Phospholipids; D014280:Triglycerides; D007862:Phosphatidylcholine-Sterol O-Acyltransferase
Phospholipide als Emulgatoren in Fettemulsionen--Einfluss auf die Phospholipide in der Serum-Lipoproteinfraktion d greater than 1.063.