title: Inhibition of glyoxalase I by various clinically used anticancer drugs.
abstract: The antiglyoxalase activity of eight well-known anticancer drugs has been evaluated, their I50 values were determinated and compared to those of standard inhibitors S-octylglutathione and squaric acid. Among them methotrexate was found to be as potent as S-octylglutathione.
authors: Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Marseille, France.
authors: J L
authors: JL
authors: Kraus
authors: P
authors: P
authors: Pernice
authors: C
authors: C
authors: Ponce
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D007791:Lactoylglutathione Lyase / Q000037:antagonists & inhibitors*; D008190:Lyases / Q000037:antagonists & inhibitors*; D008727:Methotrexate / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D008190:Lyases; D007791:Lactoylglutathione Lyase; D008727:Methotrexate