title: Prophylactic efficacy of sustained-release ivermectin against induced nematode infestations in cattle.
abstract: The efficacy of sustained-release ivermectin was evaluated against challenge infestations of gastro-intestinal nematodes in a laboratory study involving 12 treated and 12 untreated control cattle. A weighted, orally administered osmotically activated device designed to lodge in the rumeno-reticulum and to deliver ivermectin at a dosage rate of approximately 8 mg/day for a 120-day period, was administered to treated cattle. Animals were challenged with infective larvae of Bunostomum phlebotomum and Oesophagostomum radiatum approximately 4 weeks, and with Haemonchus placei, Ostertagia ostertagi, Trichostrongylus axei and Cooperia pectinata approximately 4 and 6 weeks after bolus administration. No parasites were recovered from ivermectin-treated animals, representing 100% efficacy (p less than 0.01) against challenge infestations with larvae of all of the above species. Efficacy against an incidental infestation of Trichuris spp was 92% (p less than 0.01).
authors: M.S.D. Research Centre, South Africa.
authors: M D
authors: MD
authors: Soll
authors: I H
authors: IH
authors: Carmichael
authors: R G
authors: RG
authors: Harvey
mesh_terms: D000018:Abomasum / Q000469:parasitology; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D003692:Delayed-Action Preparations; D004341:Drug Evaluation; D007422:Intestines / Q000469:parasitology; D007559:Ivermectin / Q000008:administration & dosage* / Q000627:therapeutic use; D009349:Nematode Infections / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D003692:Delayed-Action Preparations; D007559:Ivermectin