Effects of human pancreatic polypeptide on exocrine pancreatic function in conscious rats.
The effect of newly synthesized human pancreatic polypeptide (hPP) on pancreatic secretion stimulated by a diversion of bile-pancreatic juice (BPJ) from the intestine, and plasma hPP concentration were examined in conscious rats. Exogenous hPP infusion (1, 10 micrograms/kg/hr) inhibited pancreatic protein, bicarbonate and fluid outputs during BPJ diversion in a dose-dependent manner. During 1 and 10 micrograms/kg/hr hPP infusion plasma hPP immunoreactivity increased to 369 +/- 22.9 and 1,125 +/- 90.2 pg/ml, respectively. These results suggest that newly synthesized hPP has an inhibitory activity on exocrine function of the pancreas.
Funakoshi
A
A
Third Department of Internal Medicine, Kyushu University, Fukuoka, Japan.
Miyasaka
K
K
Shinozaki
H
H
Kitani
K
K
Sugiyama
N
N
Yajima
H
H
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010189:Pancreatic Juice / Q000378:metabolism; D010191:Pancreatic Polypeptide / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010191:Pancreatic Polypeptide