Immunochemical characteristics of IgG4 antibodies.
Although a small part of the IgG4 subclass probably can bind to basophils (and mast cells), IgG4 antibodies usually do not behave as anaphylactic antibodies. Therefore, detection of IgG4 antibodies in serum is not a suitable in vitro assay for IgG-S-TS activity. Furthermore, differences between IgG4 and the other IgG subclasses with respect to antibody valency and interaction with the complement system, stress the point that IgG4 takes a special place in the humoral immune response.
Van der Zee
J S
JS
Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Aalberse
R C
RC
D000818:Animals; D001491:Basophils / Q000276:immunology; D001666:Binding Sites, Antibody; D003167:Complement Activation; D006801:Humans; D007120:Immunochemistry; D007074:Immunoglobulin G / Q000276:immunology*; D008407:Mast Cells / Q000276:immunology
D007074:Immunoglobulin G