The influence of diuretics on the excretion and metabolism of doping agents. Part IV--Caffeine.
The urinary excretion of caffeine in humans was followed over a period of 36 h after the oral administration of ANIMINE, a formulation containing caffeine-alpha-naphthylacetate. The excretion of caffeine was not as markedly affected by the urinary pH as was found with stimulant amines. Excretion peaks were obtained 1-2 h after the ingestion and the total amount of unchanged caffeine excreted during 12 h varied from 0.57 to 1.51 per cent. The ingestion of the diuretics acetazolamide or furosemide 2 h after caffeine resulted in a urine-flow dependent and consequently increased caffeine excretion during 2-4 h post-diuretic. This increase paralleled the increase in urine volume resulting in no meaningful differences in caffeine concentration compared to normal conditions.
Delbeke
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FT
Laboratorium voor Farmacologie en Toxicologie der Huisdieren, Faculteit Diergeneeskunde, Rijksuniversiteti Gent, Belgium.
Debackere
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M
D000086:Acetazolamide / Q000494:pharmacology*; D002110:Caffeine / Q000008:administration & dosage / Q000652:urine*; D004300:Doping in Sports; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D009284:Naphthols / Q000008:administration & dosage
D009284:Naphthols; D002110:Caffeine; D005665:Furosemide; C027876:alpha-naphthyl acetate; D000086:Acetazolamide