[3H]yohimbine and [3H]idazoxan bind to different sites on rabbit forebrain and kidney membranes.
The binding of the alpha 2-adrenoceptor ligands [3H]yohimbine and [3H]idazoxan to rabbit kidney and forebrain membranes was compared. The maximum number of [3H]yohimbine binding sites was higher than the number of [3H]idazoxan binding sites in forebrain and lower in kidney. Large differences were observed in the ability of noradrenaline, adrenaline, idazoxan, rauwolscine, yohimbine and WY 26392 to displace [3H]yohimbine and [3H]idazoxan from their binding sites. These data suggest that [3H]idazoxan and [3H]yohimbine bind to different sites on rabbit tissue membranes.
Hamilton
C A
CA
Department of Materia Medica, Stobhill General Hospital, Glasgow, U.K.
Reid
J L
JL
Yakubu
M A
MA
D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D004146:Dioxanes / Q000378:metabolism*; D004147:Dioxins / Q000378:metabolism*; D019329:Idazoxan; D007668:Kidney / Q000378:metabolism*; D008297:Male; D011817:Rabbits; D015016:Yohimbine / Q000378:metabolism*
D004146:Dioxanes; D004147:Dioxins; D015016:Yohimbine; D019329:Idazoxan