Plant anticancer agents, XLVI. Cytotoxic casbane-type constituents of Agrostistachys hookeri.
In addition to the previously characterized agrostistachin, three additional cytotoxic macrocyclic casbane-type diterpenes were isolated from a CHCl3 extract of Agrostistachys hookeri, by bioactivity-guided fractionation using the P-388 lymphocytic leukemia cell culture system. These novel compounds, 14-dehydroagrostistachin, 17-hydroxyagrostistachin, and agroskerin, identified by spectral data comparison to agrostistachin and demonstrated ED50 values of 2.8, 0.8, and 1.4 micrograms/ml, respectively, with cultured P-388 cells.
Choi
Y H
YH
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.
Pezzuto
J M
JM
Kinghorn
A D
AD
Farnsworth
N R
NR
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010946:Plants, Medicinal / Q000032:analysis*
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes