Neurosarcoidosis associated with hypersomnolence treated with corticosteroids and brain irradiation.
Narcoleptic features developed in a young man with CNS sarcoidosis. This was associated with a structural lesion in the hypothalamus as demonstrated on CT scans of the head. The diagnosis of narcolepsy was established by compatible clinical history and the Multiple Sleep Latency Test. Treatment with high-dose corticosteroids was ineffective, but when the low-dose, whole-brain irradiation was added, complete resolution of the narcoleptic features ensued.
Rubinstein
I
I
Department of Medicine, St. Michael's Hospital, Ontario, Canada.
Gray
T A
TA
Moldofsky
H
H
Hoffstein
V
V
D000328:Adult; D001921:Brain / Q000528:radiation effects*; D002493:Central Nervous System Diseases / Q000150:complications* / Q000628:therapy; D003131:Combined Modality Therapy; D006970:Disorders of Excessive Somnolence / Q000209:etiology*; D006801:Humans; D008297:Male; D009290:Narcolepsy / Q000209:etiology*; D011241:Prednisone / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D012507:Sarcoidosis / Q000150:complications* / Q000628:therapy; D012893:Sleep Wake Disorders / Q000209:etiology*
D011241:Prednisone