Pregnancy in women with diffuse mesangial proliferative glomerulonephritis.
The clinical course of 168 pregnancies in 91 women with non-IgA diffuse mesangial proliferative glomerulonephritis has been analyzed. Twenty percent (33) of pregnancies resulted in fetal loss, 18% (31) in premature delivery and 62% (105) in a term infant. Maternal renal function declined, reversibly, in 3% (5) of pregnancies and in 48% (80) hypertension developed. In 53% (89) a significant increase in proteinuria occurred in pregnancy. Fetal and maternal complications of pregnancy occurred more frequently in patients with pre-existing hypertension although differences failed to reach statistical significance (p greater than 0.01). The presence of severe vessel lesions on the diagnostic renal biopsy was associated with a significantly higher fetal loss and prematurity rate (p less than 0.0005 and p less than 0.005, respectively).
Packham
D K
DK
Department of Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
North
R A
RA
Fairley
K F
KF
Whitworth
J A
JA
Lloren
P R
PR
Lee
E
E
Kincaid-Smith
P
P
D005260:Female; D005313:Fetal Death / Q000209:etiology; D005920:Glomerular Mesangium; D005921:Glomerulonephritis; D005923:Glomerulosclerosis, Focal Segmental; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007231:Infant, Newborn; D007234:Infant, Premature; D011247:Pregnancy; D011248:Pregnancy Complications; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology; D011256:Pregnancy Outcome; D011379:Prognosis; D011507:Proteinuria / Q000209:etiology; D012189:Retrospective Studies