title: The effect of unilateral and bilateral removal of the entorhinal cortex on the glucose utilization in various hippocampal regions in the rat.
abstract: In the present study lesion-induced changes in function of various hippocampal regions, as reflected by the metabolic rate of glucose, were measured by means of quantitative autoradiography, 4 days after unilateral or bilateral surgical removal of the entorhinal cortex. The greatest decrease (45%) was seen in the stratum lacunosum moleculare of the CA1, whereas a lesser decline (34%) was seen in the molecular layer of the dentate gyrus, stratum lucidum of the CA3 (31%) and the stratum radiatum of the CA1 (36%). These findings support the view that in addition to the indirect trisynaptic temporo-ammonic pathway, there is a functionally active direct pathway.
authors: Surgical Neurology Branch, NIH, Bethesda, MD 20892.
authors: M B
authors: MB
authors: Jørgensen
authors: D C
authors: DC
authors: Wright
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002540:Cerebral Cortex / Q000502:physiology*; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D009434:Neural Pathways / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003837:Deoxy Sugars; D003847:Deoxyglucose