Age changes in adrenergic and dopaminergic signal transduction mechanisms: parallels and contrasts.
Age changes in signal transduction exhibit some interesting similarities in the adrenergic and dopaminergic systems of the brain. Although several differences exist with respect to current technical capabilities and characterization of complete signal-response pathways at the organismic level, these systems offer promising models for complimentary elucidation of the mechanisms of altered neurotransmitter action during aging.
Roth
G S
GS
Molecular Physiology and Genetics Section, National Institute on Aging, Francis Scott Key Medical Center, Baltimore, MD.
D000375:Aging / Q000502:physiology*; D000818:Animals; D001696:Biomechanical Phenomena; D001921:Brain / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D011941:Receptors, Adrenergic / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000502:physiology*
D011941:Receptors, Adrenergic; D004298:Dopamine