Bacteremia in patients undergoing oral procedures. Study following parenteral antimicrobial prophylaxis as recommended by the American Heart Association, 1977.
The type and rate of bacteremia following dental extractions, dental cleaning, or other dental/oral surgical procedures were studied in 124 patients with valvular heart disease following parenteral antibiotic prophylaxis (penicillin G potassium with or without streptomycin sulfate, or vancomycin hydrochloride) as recommended by the American Heart Association in 1977. Generally, under penicillin G prophylaxis with or without streptomycin, detection of bacteremia in blood culture media containing no penicillinase was low (14.7% to 16.1% at five minutes and 3.1% to 9.0% at 30 minutes after the procedure). The number and types of organisms recovered from patients who received penicillin prophylaxis alone or with streptomycin were similar. Anaerobes were recovered twice as frequently as aerobes. Polymicrobial bacteremia was rare and only one patient had streptococci detected in the blood culture. Addition of penicillinase to one blood culture medium, however, and comparing it with a similar medium without penicillinase was accompanied with a sixfold greater recovery from patients of both aerobic and anaerobic bacteria, including six patients with streptococcal bacteremia. Vancomycin prophylaxis was accompanied with bacteremia in only one patient.
Baltch
A L
AL
Department of Medicine, Veterans Administration Medical Center, Albany, NY 12208.
Pressman
H L
HL
Schaffer
C
C
Smith
R P
RP
Hammer
M C
MC
Shayegani
M
M
Michelsen
P
P
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001419:Bacteria / Q000302:isolation & purification; D003729:Dental Care; D004359:Drug Therapy, Combination; D006349:Heart Valve Diseases / Q000150:complications* / Q000382:microbiology; D006801:Humans; D010400:Penicillin G / Q000008:administration & dosage; D011292:Premedication; D018805:Sepsis / Q000382:microbiology / Q000517:prevention & control*; D013307:Streptomycin / Q000008:administration & dosage; D014640:Vancomycin / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D014640:Vancomycin; D010400:Penicillin G; D013307:Streptomycin