title: On a new class of mixed-function drugs associating nitroimidazoles and CENU: the NICE-NU.
abstract: Two series of (2-chloroethyl) nitrosoureas (NICE-NU) bearing a nitroimidazole group have been synthesized for anti-tumor evaluation with the aim of chemopotentiation of their biological activity. Their anti-tumor activity against L1210 in vivo in mice is excellent especially for the series A derivatives where a hydroxy function provides assistance to decomposition. However, the activity of NICE-NU against B16 melanoma is lower.
authors: Laboratoire de Chimie Bio-Organique, UA au CNRS, USTL, France, Montpellier.
authors: A
authors: A
authors: Carminati
authors: J L
authors: JL
authors: Barascut
authors: E
authors: E
authors: Chenut
authors: C
authors: C
authors: Bourut
authors: G
authors: G
authors: Mathé
authors: J L
authors: JL
authors: Imbach
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007939:Leukemia L1210 / Q000188:drug therapy; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D009593:Nitroimidazoles; D009603:Nitroso Compounds; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009593:Nitroimidazoles; D009603:Nitroso Compounds; C041148:N-(2-chloroethyl)-N-nitrosoacetamide