Ultrastructural localization of cisplatin in Ehrlich ascites tumor cells.
The incorporation of cis-diammine Dichloro Platinum (II) (cisplatin) on the Ehrlich ascites carcinoma (EAT) cells has been studied in this paper. Ultrastructural study of cells treated 'in vivo' with cisplatin showed that a new treatment with this substance after fixation, blocks uranyl acetate staining with the consequent lack of heterochromatin contrast.
Rodilla
V
V
Department of Animal Biology, University of Valencia, Spain.
Pertusa
J
J
Pellicer
J A
JA
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000032:analysis* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000032:analysis; D002945:Cisplatin / Q000032:analysis*; D004247:DNA / Q000032:analysis; D005260:Female; D051379:Mice; D009942:Organometallic Compounds; D014018:Tissue Distribution
D009942:Organometallic Compounds; C005460:uranyl acetate; D004247:DNA; D002945:Cisplatin