Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. II. Structural determination and total synthesis.
The structure of neihumicin, a new antibiotic isolated from the fermentation broth of Micromonospora neihuensis Wu, sp. nov., has been determined as (Z)-3,(Z)-6-dibenzylidene-2-methoxy-3,6-dihydropyrazin-5-one based upon spectral evidence and X-ray crystallographic analysis. Its total synthesis has also been achieved.
Yang
L M
LM
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27514.
Wu
R Y
RY
McPhail
A T
AT
Yokoi
T
T
Lee
K H
KH
D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D011719:Pyrazines / Q000138:chemical synthesis
D000903:Antibiotics, Antineoplastic; D011719:Pyrazines; C056028:neihumicin