Primidone and essential tremor.
To clarify whether primidone itself, and not only its metabolite phenobarbitone, suppresses essential tremor, the effect of a high single dose of primidone was tested. Of 11 patients, 8 showed a reduction of their tremor by 54%-69% for up to 28 h. The serum concentration of primidone was as expected, whereas those of the metabolites phenyl-ethyl-malonamide and phenobarbitone were very low. The tremor suppression can thus be considered to be an effect of primidone. Three of the 11 patients did not show a reduction of tremor.
Seyfert
S
S
Neurologische Klinik, Klinikum Steglitz, Freie Universität Berlin.
Honé
A
A
Holl
G
G
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000097:blood; D010657:Phenylethylmalonamide / Q000097:blood; D011324:Primidone / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D014202:Tremor / Q000188:drug therapy*
D011324:Primidone; D010657:Phenylethylmalonamide; D010634:Phenobarbital