[Passive avoidance in amygdalectomized rats as affected by methylphenidate and midantan].
It is shown that disturbance of conditioned reaction of passive avoidance in Wistar rats, elicited after bilateral amygdalectomy, may be compensated by administration of indirect dopamine agonist--methylphenidate. Two-fold administration proved to be effective: that before learning and that before testing. Two-fold administration of another dopamine agonist--amantadine did not restore the disturbed conditioned reaction. The results are discussed in the aspect of the role of different dopamine brain systems in passive avoidance and possible specificity of the drugs action.
Gilinskiĭ
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D000547:Amantadine / Q000494:pharmacology*; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects; D018492:Dopamine Antagonists; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D018492:Dopamine Antagonists; D008774:Methylphenidate; D000547:Amantadine
Passivnoe izbeganie u amigdaléktomirovannykh krys pri deĭstvii metilfenidata i midantana.