[Cytotoxic action of the individual membrane components of Mycoplasma arthritidis and M. fermentans on rat lymphocytes].
Study of the toxic properties of the preparations obtained from M. arthritidis has revealed that the cytotoxic activity of M. arthritidis is mainly linked with the cytoplasmic membrane and, partially, with the cytoplasmic fraction. The membrane substances of M. fermentans and the products of its vital activity are toxic with respect to target cells, the component translocated into the culture medium consisting of globular proteins. Interaction of the cytoplasmic membranes of these Mycoplasma species, as well as of the fractions of M. fermentans globular proteins, with rat lymphocytes is accompanied by a cytodestructive effect and an increased permeability for toxic dyes.
Gorina
L G
LG
Zil'fian
A V
AV
Saiadian
Kh S
KhS
Goncharova
S A
SA
Vartanian
A V
AV
D000818:Animals; D002458:Cell Fractionation; D002462:Cell Membrane / Q000276:immunology; D002463:Cell Membrane Permeability; D003593:Cytoplasm / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic; D004306:Dose-Response Relationship, Immunologic; D006386:Hemagglutination Tests; D008055:Lipids / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D009174:Mycoplasma / Q000276:immunology*; D051381:Rats
D008055:Lipids
Tsitotoksicheskoe deĭstvie otdel'nykh komponentov membran Mycoplasma arthritidis i M. fermentans na limfotsity krys.