[The quantitative identification of metabolites of dihydralazine in the human].
The metabolism of dihydralazine sulfate was studied in 11 hypertonic patients treated with that drug chronically. The metabolites were identified in urine with gc, dc, and hplc by comparison with synthesized reference compounds. Following metabolites could be verified: acetylated products, oxidation products, hydrazones and products of decomposition. Products resulting from reaction with nitrites could be not detected.
Schneider
T
T
Institut für Klinische Pharmakologie, Ernst-Moritz-Arndt-Universität Greifswald.
Siegmund
W
W
Zschiesche
M
M
Kallwellis
R
R
Scherber
A
A
D000328:Adult; D000368:Aged; D001711:Biotransformation; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D004078:Dihydralazine / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged
D006830:Hydralazine; D004078:Dihydralazine
Zum qualitativen Nachweis von Metaboliten des Dihydralazins beim Menschen.