Apnoea associated with the intrathecal administration of morphine in obstetrics. A case report.
The intrathecal administration of hyperbaric morphine 1 mg for pain relief during labour was followed, 7 h after injection, and 1 h after delivery, by respiratory depression. Pulseoximetry was helpful in alerting the medical personnel. After an initial 1 mg of naloxone i.v. in increments of 0.1-0.2 mg, a continuous infusion of naloxone 0.4 mg h-1 i.v. was used to prevent a recurrence of the respiratory depression. The total dose of naloxone over an 8-h period was 3.6 mg.
Abouleish
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University of Texas Health Science Center, Medical School, Department of Anesthesiology, Houston 77030.
D000328:Adult; D000773:Anesthesia, Obstetrical; D001049:Apnea / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007278:Injections, Spinal; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy; D011644:Puerperal Disorders / Q000139:chemically induced*; D012131:Respiratory Insufficiency / Q000139:chemically induced
D009020:Morphine