title: Cadmium chloride induces contractions of the rat isolated urinary bladder by activation of capsaicin-sensitive sensory nerves.
abstract: Cadmium chloride (CdCl2)(30 microM-1 mM) produced a concentration-related contraction of the rat isolated urinary bladder which was abolished by tetrodotoxin (1 microM) or extrinsic bladder denervation (72 h before). Complete cross-desensitization was observed between the contractile response to Cd and capsaicin, indicating that, at the peripheral level, this inorganic calcium channel blocker can activate the 'efferent' function of capsaicin-sensitive sensory nerves.
authors: Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
authors: R
authors: R
authors: Patacchini
authors: P
authors: P
authors: Santicioli
authors: S
authors: S
authors: Giuliani
authors: C A
authors: CA
authors: Maggi
authors: A
authors: A
authors: Meli
mesh_terms: D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D002211:Capsaicin / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011984:Sensory Receptor Cells / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation*
chemical_list: D002104:Cadmium; D002211:Capsaicin