title: Preferential oxygen supply to the brain and upper body in the fetal pig.
abstract: In the fetal pig over 50% of the oxgenated umbilical venous blood bypasses the liver via vascular channels of over 100mu diameter which appear to act as a ductus venosus (DV). In the present experiments the oxygen levels (pO2, SO2 and O2 content) in the fetal carotid (CA) and femoral (FA) arteries were measured to determine whether preferential streaming of the oxygenated blood is maintained from the bypass to the foramen ovale and thence through the left heart to the upper body, as in other species. The results were obtained from 12 piglets catheterized and maintained in utero under sodium pentobarbitone anaesthesia. Significant CA-FA differences in pO2, SO2 and O2 content were observed in these fetuses during both normoxaemia and hypoxaemia showing that a higher level of oxygen can be maintained to the fetal head and brain over a wide range of oxygenation. These results confirm that the hepatic channels in the fetal piglet act as a fully functional DV.
authors: Physiological Laboratory, Cambridge, England.
authors: M
authors: M
authors: Silver
authors: R J
authors: RJ
authors: Barnes
authors: A L
authors: AL
authors: Fowden
authors: R S
authors: RS
authors: Comline
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005333:Fetus / Q000502:physiology*; D008102:Liver Circulation; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D011247:Pregnancy; D012039:Regional Blood Flow; D013552:Swine; D014471:Umbilical Veins / Q000502:physiology
chemical_list: D010100:Oxygen