[Preclinical results with 15-deoxyspergualin in experimental graft versus host disease].
The efficacy of 15-deoxyspergualin (15-DS) was tested in two models of experimental graft versus host disease (GvHD) in mice. In both models, which lead to a hemolytic anemia or to a glomerulonephritis respectively followed by subsequent death of the animals, 15-deoxyspergualin showed good therapeutic effects.
Dickneite
G
G
Forschungslaboratorien der Behringwerke AG, Marburg.
Schorlemmer
H U
HU
Sedlacek
H H
HH
D000743:Anemia, Hemolytic / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005921:Glomerulonephritis / Q000209:etiology / Q000517:prevention & control; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006146:Guanidines / Q000627:therapeutic use; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains
D000903:Antibiotics, Antineoplastic; D006146:Guanidines; C037258:gusperimus
Präklinische Untersuchungen mit 15-Deoxyspergualin bei experimenteller Graft-versus-host-Erkrankung (GvHD).