Serotonin reduction in the mouse neostriatum during hyperthermia-induced convulsions studied by immunohistochemistry.
Changes occurring in serotonin neurons during hyperthermia-induced convulsions were examined by means of a modified immunohistochemical method. All mice (8-12 weeks of age) exposed to the temperature of 50 degrees C had convulsions, showing a generalized tonic and/or clonic pattern. Immediately after the convulsions, the animals were perfused transcardially with a fixative. A significant reduction in serotonin immunoreactivity was observed in the neostriatum (caudate-putamen complex) of the mice which had hyperthermia-induced seizures, while the serotonin immunoreactivity remained unchanged in the neocortex and paleostriatum. These results suggest that serotonin may be an important mediator in the mechanism of hyperthermia-induced convulsions or that the susceptibility of serotonin neurons to a convulsive state is greatest in the neostriatum.
Takeuchi
Y
Y
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
Fujiwara
K
K
Ishimura
K
K
Yoshioka
H
H
Sawada
T
T
D000818:Animals; D001923:Brain Chemistry; D003342:Corpus Striatum / Q000032:analysis*; D006358:Hot Temperature / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012640:Seizures / Q000209:etiology / Q000378:metabolism*; D012701:Serotonin / Q000032:analysis*
D012701:Serotonin