Differential effects of phorbol esters on c-fos and c-myc and ornithine decarboxylase gene expression in mouse skin in vivo.
Hyperplasiogenic and tumor-promoting phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate or 12-O-retinoylphorbol-13-acetate induce the sequential transient expression of the proto-oncogenes c-fos and c-myc and the ornithine decarboxylase gene in mouse skin in vivo. This sequence of biochemical events probably depends on an activation of protein kinase C by these agents. The non-irritant skin mitogens 4-O-methyl-12-O-tetradecanoylphorbol-13-acetate and ethyl phenyl propiolate do not increase the expression of these genes to a comparable extent. Thus, 12-O-tetradecanoylphorbol-13-acetate and 12-O-retinoylphorbol-13-acetate induce epidermal hyperproliferation by different biochemical mechanisms as do 4-O-methyl-12-O-tetradecanoylphorbol-13-acetate and ethylphenylpropiolate.
Rose-John
S
S
Institute for Biochemistry, German Cancer Research Center, Heidelberg.
Fürstenberger
G
G
Krieg
P
P
Besemfelder
E
E
Rincke
G
G
Marks
F
F
D000818:Animals; D005260:Female; D006965:Hyperplasia; D051379:Mice; D009955:Ornithine Decarboxylase / Q000235:genetics*; D010703:Phorbol Esters / Q000633:toxicity*; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000032:analysis; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
D010703:Phorbol Esters; D012333:RNA, Messenger; C032974:12-O-retinoylphorbol-13-acetate; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate