A developmental toxicity evaluation of gossypol.
In utero development was analyzed in pregnancies that resulted from matings between gossypol-treated male rats and untreated female rats, and in pregnancies in which gossypol was administered to the pregnant rat only. Gossypol treatment of males had no effect on the outcome of pregnancy. There was no significant effect on resorption, fetal growth, or malformation rate. Similarly, gossypol administered to pregnant dams at stages during organogenesis had no observable effect on pregnancy. Under the conditions of this experiment, gossypol administered to either the breeding male rat or the pregnant female rat had no demonstrable adverse effect on development in utero.
Beaudoin
A R
AR
Department of Anatomy and Cell Biology, University of Michigan, Ann Arbor 48109.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003272:Contraceptive Agents, Male / Q000633:toxicity*; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005327:Fetal Resorption; D006072:Gossypol / Q000633:toxicity*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D013089:Spermatocidal Agents / Q000633:toxicity*
D003272:Contraceptive Agents, Male; D013089:Spermatocidal Agents; D006072:Gossypol