LSD: permanent behavioral effect in rats.
Rats with a unilateral nigrostriatal lesion produced by infusion of 6-hydroxydopamine (6-OHDA) exhibited acute contralateral (apomorphine-like) rotation in response to systemic LSD administration. When re-introduced to the environment in which LSD had been administered weeks earlier, the animals exhibited a 2-3 min burst of contralateral rotation. This behavior developed over a period of weeks and could be produced by a single LSD treatment. This latent, undrugged rotation is similar to that which we previously reported to result from one or more apomorphine treatments.
Silverman
P B
PB
Department of Psychiatry and Behavioral Sciences, University of Texas Medical School, Houston 77030.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012399:Rotation; D013239:Stereotyped Behavior / Q000187:drug effects*
D008238:Lysergic Acid Diethylamide; D001058:Apomorphine