Persistent intrathecal secretion of oligoclonal, Borrelia burgdorferi-specific IgG in chronic meningoradiculomyelitis.
In the cerebrospinal fluid IgG of five patients with lymphomeningoradiculitis (Bannwarth's syndrome) and radiculomyelitis studied by immunoblot technique an oligoclonal pattern was found. Most of these oligoclonal bands were specific for Borrelia burgdorferi. In patients suffering from chronic meningoradiculomyelitis, repeated CSF examination by this technique showed persistent secretion of identical IgG bands. Thus, the specific humoral immune response and the disease activity could be documented over the course of the disease.
Martin
R
R
Abteilung Neurologie, Universität Würzburg, Federal Republic of Germany.
Martens
U
U
Sticht-Groh
V
V
Dörries
R
R
Krüger
H
H
D000907:Antibodies, Bacterial / Q000032:analysis*; D000917:Antibody Formation; D001898:Borrelia / Q000276:immunology*; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis*; D008193:Lyme Disease / Q000175:diagnosis / Q000276:immunology*; D008581:Meningitis / Q000175:diagnosis / Q000276:immunology*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G