Carcinogenic effect of N-nitrosotriethylurea in single administration to female rats.
N-Nitrosotriethylurea (NTEU) was administered once into the stomach or intravenously to outbred female rats. The rats given NTEU by oral administration developed malignant tumours of the mammary gland, uterus and liver. The rats exposed to NTEU by i.v. administration developed tumours of the mammary gland and ovaries. NTEU accelerated the appearance of tumours which are normally characteristic of the rat stock used (tumours of the pituitary, thyroid, adrenal cortex, fibroadenoma of the mammary gland, endometrial polyps.
Anisimov
V N
VN
N.N. Petrov Research Institute of Oncology, USSR Ministry of Health, Leningrad.
Alexandrov
V A
VA
Petrov
A S
AS
Lijinsky
W
W
D000818:Animals; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D009607:Nitrosourea Compounds / Q000633:toxicity*; D010051:Ovarian Neoplasms / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D014594:Uterine Neoplasms / Q000139:chemically induced
D009607:Nitrosourea Compounds; C026465:triethylnitrosourea