[Changes in the sensitivity of lymphocytes to serotonin in patients with rectal cancer].
The inhibitory action of serotonin (10(-6) M and higher) in an in vitro lymphocyte adherence inhibition test appeared to be levelled off by methysergide, suggesting the involvement of serotonin receptors in the effect. A comparative evaluation of serotonin action in patients with stage I-IIA (group 1), stage IIIB-IV (group 2) rectal cancer and recurrent disease (group 3) showed lymphocyte sensitivity to serotonin in vitro to be significantly higher in groups 2 and 3, as compared to group 1.
Kharkevich
D D
DD
Kadagidze
Z G
ZG
D006801:Humans; D007957:Leukocyte Adherence Inhibition Test; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D012004:Rectal Neoplasms / Q000276:immunology*; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin
Izmenenie chuvstvitel'nosti limfotsitov k serotoninu u bol'nykh rakom priamoĭ kishki.