Clinical findings in patients with SLE whose sera contain antibodies to ribosomal ribonucleoprotein.
In a clinical and serological study performed on a large series of patients with different connective tissue diseases, anti-ribosomal ribonucleoprotein (rRNP) antibodies were detected only in a small proportion of sera with systemic lupus erythematosus (SLE). SLE patients positive for anti-rRNP autoantibodies showed a significantly higher incidence of hemolytic anemia. The reasons for this surprising association are still unclear; however, this finding suggests that rRNP precipitin might be considered as a useful marker of a particular subgroup of patients with SLE.
Asero
R
R
Istituto di Medicina Interna, Università degli Studi di Milano, Italia.
D'Agostino
P
P
Bertetti
E
E
Origgi
L
L
Riboldi
P
P
D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology; D001323:Autoantibodies / Q000032:analysis*; D006801:Humans; D007970:Leukopenia / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology* / Q000473:pathology; D011234:Precipitins / Q000032:analysis; D012261:Ribonucleoproteins / Q000276:immunology*; D012270:Ribosomes / Q000276:immunology*
D001323:Autoantibodies; D011234:Precipitins; D012261:Ribonucleoproteins