The effect of food on the absorption of slow-release isosorbide-5-mononitrate tablets.
The influence of food on the absorption characteristics of slow release isosorbide-5-mononitrate tablets was investigated in 10 normal healthy volunteers. There were no differences in the peak concentration achieved or the area under the curve, but the peak concentration occurred later when the drug was administered after food. The apparent elimination half-life ranged from 4.7 to 10.1 h. Bioavailability of slow-release isosorbide-5-mononitrate is therefore unaffected by food, but there is a slower rate of absorption.
Thomson
A H
AH
Department of Materia Medica, University of Glasgow, Stobhill General Hospital, U.K.
Miller
S H
SH
Green
S T
ST
Whiting
B
B
D000042:Absorption; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D001794:Blood Pressure / Q000187:drug effects; D002849:Chromatography, Gas / Q000379:methods; D003692:Delayed-Action Preparations; D005260:Female; D005502:Food; D006207:Half-Life; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics; D008297:Male; D011897:Random Allocation; D012044:Regression Analysis; D013607:Tablets; D013997:Time Factors
D003692:Delayed-Action Preparations; D013607:Tablets; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate