Interstitial misonidazole: clinical experience in advanced mouth cancer.
In an attempt to obtain full radiosensitisation and avoid dose-limiting neurotoxicity, a needle has been specially developed for the injection of misonidazole pellets into tumours. The methods of production and insertion of the pellets are described. Thirteen advanced, untreated squamous carcinomas of the mouth were injected and then irradiated to tolerance. Twelve out of 13 implanted lesions had completely regressed at the end of treatment but only six remained healed after 1 year.
Sealy
R
R
Department of Radiotherapy, Groote Schuur Hospital.
Cridland
S
S
Blekkenhorst
G
G
Barry
L
L
Rombouts
T
T
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D004343:Drug Implants; D006801:Humans; D008920:Misonidazole / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D009062:Mouth Neoplasms / Q000532:radiotherapy*; D009339:Needles; D009364:Neoplasm Recurrence, Local; D013552:Swine
D004343:Drug Implants; D008920:Misonidazole