Reduced cyclic myopia with pilocarpine gel.
Pilocarpine 4% gel and pilocarpine 4% solution were compared in young normal subjects for their effects on induced myopia. The pilocarpine 4% solution produced marked myopia lasting one to two hours which indicates that a qid therapeutic regimen produces about three to six hours of blurred vision during waking hours. The gel-induced myopic effects returned to normal in most subjects nine hours after a single instillation. Thus, pilocarpine-gel-induced myopic effects occur principally while asleep and are reduced substantially upon awakening. This allows patients to carry on normal activities throughout the day.
Mandell
A I
AI
Mid-South Glaucoma and Cataract Foundation, Memphis, Tennessee 38119.
Bruce
L A
LA
Khalifa
M A
MA
D000328:Adult; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D009216:Myopia / Q000139:chemically induced* / Q000503:physiopathology; D010862:Pilocarpine / Q000008:administration & dosage* / Q000009:adverse effects; D012996:Solutions; D013997:Time Factors
D005782:Gels; D012996:Solutions; D010862:Pilocarpine