title: Sialic acid concentration in erythrocyte membrane subfractions in patients with myotonic dystrophy and healthy controls.
abstract: Previous studies have shown a selective reduction of the sialic acid concentration in erythrocyte membranes in patients with myotonic dystrophy. In order to locate this deficiency, chloroform/methanol/H2O extractions of erythrocyte membranes were analyzed in patients with myotonic dystrophy and in matched healthy reference individuals. In the patients, significant reductions of the sialic acid concentration were found in the aqueous phase (p = 0.03) containing mainly glycophorin A as well as in the band-3-containing interphase (p less than 0.005). These findings may be related to certain previously reported membrane abnormalities in myotonic dystrophy.
authors: Department of Neurology, Karolinska Hospital, Stockholm, Sweden.
authors: O
authors: O
authors: Sydow
mesh_terms: D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000032:analysis; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009136:Muscular Dystrophies / Q000378:metabolism*; D012794:Sialic Acids / Q000097:blood*; D013347:Subcellular Fractions / Q000378:metabolism
chemical_list: D001798:Blood Proteins; D012794:Sialic Acids