title: [Trial of the combined use of trental and solcoseryl in treating patients with chronic pancreatitis].
abstract: The effect of combined use of pentoxifylline and solcoseryl was studied in 35 patients with chronic pancreatitis. General clinical findings were studied in parallel with the time course of pancreatic exocrine (trypsin) and endocrine (insulin, C-peptide) function. The blood level of gastrin and changes in intestinal function using 131I-lipids were also studied. The incorporation of both drugs in multimodality therapy made a positive therapeutic effect, resulting in a decrease in the pain syndrome and dyspeptic symptoms. At the same time some favorable shifts in pancreatic and GI tract function were noted. Possible mechanisms of a positive therapeutic effect were discussed. A conclusion was made that the incorporation of pentoxifylline and solcoseryl in multimodality therapy of chronic pancreatitis was clinically justified and determined pathogenetically.
authors: Ia M
authors: IaM
authors: Vakhrushev
authors: V V
authors: VV
authors: Trusov
authors: N E
authors: NE
authors: Solov'eva
mesh_terms: D000183:Actihaemyl / Q000627:therapeutic use*; D000328:Adult; D002908:Chronic Disease; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D010195:Pancreatitis / Q000188:drug therapy* / Q000503:physiopathology; D010431:Pentoxifylline / Q000627:therapeutic use*; D013805:Theobromine / Q000031:analogs & derivatives*; D014020:Tissue Extracts / Q000627:therapeutic use*
chemical_list: D014020:Tissue Extracts; D000183:Actihaemyl; D013805:Theobromine; D010431:Pentoxifylline
vernacular_title: Opyt sochetannogo primeneniia trentala i solkoserila v lechenii bol'nykh khronicheskim pankreatitom.