[Visual disorders caused by diphenylhydantoin: clinical and electro-ophthalmologic findings].
In 1981 a 47-year-old white woman was given a total of 9 g of DPH for treatment of epilepsy. A rare hereditary defect in the metabolism of this drug caused toxic blood levels for about three months and led to persistent neurologic and ophthalmologic disturbances. In addition to an atrophy of the cerebellum, demonstrated by a CT scan, the predominant ophthalmologic findings were bilateral reduced visual acuity (0.1) and restricted visual fields (15 degrees). Despite intensive clinical and electrophysiologic investigations it proved impossible to localize the site of damage in the ascending visual pathway. Only VECP to patterns of low contrast (0.2) exhibited a pathologic response. It was concluded that persistent visual disturbances due to DPH intoxication are caused by a more centrally located action of this drug.
Lorenz
R
R
Arbeitsgemeinschaft II. Physiologische Abteilung, Max-Planck-Institut für Physiologische und Klinische Forschung Bad Nauheim.
Kuck
H
H
D004585:Electrooculography; D004596:Electroretinography; D004827:Epilepsy / Q000188:drug therapy*; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D014786:Vision Disorders / Q000139:chemically induced*
D010672:Phenytoin
Visuelle Störungen durch Diphenylhydantoin: Klinische und elektroophthalmologische Befunde.