Lack of effect of cicletanine on plasma digoxin levels.
Six patients stabilized on long-term once daily oral digoxin were entered into a study to monitor the effect of adding a single dose of oral cicletanine (50 or 100 mg) on plasma digoxin levels. The study was performed over 2 days, a control day and a second involving the addition of the test drug to the patient's medication. No significant change in plasma digoxin concentration was found and the combined treatment was well tolerated in terms of clinical and laboratory parameters.
Clement
D L
DL
Department of Cardiology, University Hospital, Ghent, Belgium.
Teirlynck
O
O
Belpaire
F
F
D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004077:Digoxin / Q000097:blood*; D004232:Diuretics / Q000009:adverse effects* / Q000627:therapeutic use; D004347:Drug Interactions; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011725:Pyridines
D000889:Anti-Arrhythmia Agents; D004232:Diuretics; D011725:Pyridines; D004077:Digoxin; C038068:cicletanine