title: Sympathetic stimulation and hypertension in the pyridoxine-deficient adult rat.
abstract: Pyridoxal phosphate is the coenzyme of various decarboxylases involved in the formation of monoamine neurotransmitters such as gamma-aminobutyric acid, serotonin, dopamine, and norepinephrine. Adult male Sprague-Dawley rats placed on a pyridoxine-deficient diet for 8 weeks showed significant hypertension compared with pyridoxine-supplemented controls. Hypothalamic contents of pyridoxal phosphate, gamma-aminobutyric acid, and serotonin in the pyridoxine-deficient rats were significantly lower than those in pyridoxine-supplemented controls. Hypertension was associated with sympathetic stimulation. Treatment of pyridoxine-deficient rats with a single dose of pyridoxine (10 mg/kg body weight) reversed the blood pressure to normal levels within 24 hours, with concomitant restorations of hypothalamic serotonin and gamma-aminobutyric acid as well as the return of plasma norepinephrine and epinephrine to normal levels. Also, pyridoxine treatment reversed the hypothalamic hypothyroidism observed in pyridoxine-deficient rats. These results indicate an association between pyridoxine deficiency and sympathetic stimulation leading to hypertension.
authors: Department of Biochemistry, University of Manitoba, Winnipeg, Canada.
authors: C S
authors: CS
authors: Paulose
authors: K
authors: K
authors: Dakshinamurti
authors: S
authors: S
authors: Packer
authors: N L
authors: NL
authors: Stephens
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004298:Dopamine / Q000378:metabolism; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D011732:Pyridoxal Phosphate / Q000378:metabolism; D011736:Pyridoxine / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013963:Thyroid Hormones / Q000378:metabolism; D026681:Vitamin B 6 Deficiency / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D013963:Thyroid Hormones; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D011732:Pyridoxal Phosphate; D011736:Pyridoxine; D004298:Dopamine; D009638:Norepinephrine