title: Evaluation of praziquantel against induced Nanophyetus salmincola infections in coyotes and dogs.
abstract: Efficacy of praziquantel against Nanophyetus salmincola, the trematode vector of salmon poisoning disease, was determined in coyotes (n = 29) and dogs (n = 25). The 10- to 14-week-old animals were fed fish or fish kidneys that contained metacercariae of N salmincola. To prevent salmon poisoning disease, all animals were treated with tetracycline on days 8 and 9 after they were fed fish. Ten days after ingestion of infected fish, 19 coyotes and 12 dogs were treated once with praziquantel, administered SC or IM, at dosages between 6.68 and 38.73 mg/kg of body weight. Within 8 days after treatment, the numbers of trematode eggs in feces and trematodes recovered from the small intestine were reduced by greater than 99% when compared with untreated controls. Signs of drug toxicosis were not observed. On the basis of these results, praziquantel at doses approved for use in dogs against cestodes was highly effective against N salmincola in coyotes and dogs.
authors: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.
authors: W J
authors: WJ
authors: Foreyt
authors: J R
authors: JR
authors: Gorham
mesh_terms: D000818:Animals; D002335:Carnivora / Q000469:parasitology*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D011223:Praziquantel / Q000627:therapeutic use*; D012474:Salmon / Q000469:parasitology; D014201:Trematode Infections / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D011223:Praziquantel