title: [Synthesis and pharmacological properties of des-9-glycine analogs of [Orn8]vasopressin].
abstract: Three new analogues of vasopressin, viz. des-Gly9-[Phe2, Orn8]vasopressin, diglycyl-des-Gly9-[Phe2, Orn8]vasopressin, and diglycyl-des-Gly9-[Val4, Orn8]vasopressin, were synthesized to investigate the structure-function relationship. Hormonal (vasopressor, antidiuretic, uterotonic, galactogogic) activities of the new compounds were determined, their effect on elaboration and retention of the active avoidance behaviour in rats was studied.
authors: O S
authors: OS
authors: papsuevich
authors: T
authors: T
authors: Barth
authors: G I
authors: GI
authors: Chipens
authors: V D
authors: VD
authors: Bakharev
authors: E A
authors: EA
authors: Gaĭlite
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002942:Circular Dichroism; D003214:Conditioning, Classical / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D009951:Ornipressin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D014667:Vasopressins / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C056233:vasopressin, 9-des-Gly-(2-Phe-8-Orn)-; D014667:Vasopressins; C056234:vasopressin, 2-Gly-9-des-Gly-2-Phe-8-Orn-; C056241:vasopressin, 2-Gly-9-des-Gly-4-Val-8-Orn-; D009951:Ornipressin
vernacular_title: Sintez i farmakologicheskie svoĭstva dez-9-glitsinovykh analogov [Orn8]vazopressina.