[Study of the Thomsen-Friedenreich antigen in bladder tumors].
Thomsen Friedenreich antigen (T-ag), ABH isoantigen (ABH-ag) in 106 cases with bladder tumor (all transitional cell carcinoma) of various histological grades and stages were investigated by the Avidin-Biotin-Peroxidase Complex (ABC) method. There was a correlation between histological grade, stage and deletion of the antigenicity (T-ag and ABH-ag). In a follow-up study of 45 patients with low grade and low stage tumor, the recurrence rate after surgery of the cases with abnormal antigenicity (T-ag and ABH-ag) was significantly higher than that of the cases with the normal antigenicity. Combination of two markers (T-ag and ABH-ag) was significantly more effective than the single marker.
Fukatsu
H
H
Department of Urology, Aichi Medical University.
Yamada
H
H
Nonomura
H
H
Miyagawa
Y
Y
Waki
M
M
Hatano
Y
Y
Hiraiwa
S
S
Muramatsu
T
T
Nishikawa
E
E
Yamada
Y
Y
D000017:ABO Blood-Group System / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor / Q000032:analysis; D002295:Carcinoma, Transitional Cell / Q000276:immunology*; D004187:Disaccharides / Q000032:analysis*; D006801:Humans; D001749:Urinary Bladder Neoplasms / Q000276:immunology*
D000017:ABO Blood-Group System; D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D004187:Disaccharides; C016467:Thomsen-Friedenreich antigen