Habenular lesion attenuates methamphetamine-induced inhibition of dopamine neuronal activity in the substantia nigra pars compacta of rats.
The relation between the habenula and central dopaminergic system was investigated by examining the inhibitory effects of methamphetamine on the firing rate of dopamine neurons in the substantia nigra of habenular lesioned and unlesioned rats. Electrolytic lesions of the habenula attenuated the methamphetamine-induced inhibition of dopamine neurons in the substantia nigra. This, along with other findings, indicates possibly that the habenula is involved in a feedback pathway from the striatum to the substantia nigra and regulates the activity of dopamine neurons in the substantia nigra.
Sasaki
K
K
Scientific Instrument Center, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Suda
H
H
Watanabe
H
H
Kaneko
S
S
Nomura
Y
Y
Nishino
H
H
Ono
T
T
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003051:Cochlea / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*
D008694:Methamphetamine; D004298:Dopamine