[Lipogenesis, aging and hormonal regulation].
Thyroid hormones stimulate hepatic synthesis of fatty acids, as well as the activities of lipogenic enzymes. According to the present study, an age-dependence factor is also partially present. In livers of 3- and 18-month-old rats of the Wistar strain, both the velocity of fatty acid synthesis and the activities of lipogenic enzymes were measured in dependence on thyroid function. An impaired stimulation of malic enzyme activity under the conditions of hyperthyreosis was found in the older animals. The rate of fatty acid synthesis was diminished in the group of 18-month-old rats, but there was no age-dependence in respect of the effect of a variation in thyroid status. In adipose tissue of older animals, the activities of lipogenic enzymes were lowered. In this tissue no effects of thyroid hormones in both young and old rats were observed.
Rassoul
F
F
Institut für Klinische Chemie, Karl-Marx-Universität Leipzig.
Klein
C
C
Richter
V
V
Rotzsch
W
W
D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D000375:Aging / Q000502:physiology*; D000818:Animals; D005227:Fatty Acids / Q000096:biosynthesis*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006980:Hyperthyroidism / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008291:Malate Dehydrogenase / Q000378:metabolism; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013963:Thyroid Hormones / Q000502:physiology*
D005227:Fatty Acids; D013963:Thyroid Hormones; D008291:Malate Dehydrogenase; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D001275:ATP Citrate (pro-S)-Lyase
Lipogenese, Altern und hormonale Regulation.