Retinoic acid supplementation of a vitamin A-deficient diet inhibits retinoid loss from hamster liver and serum pools.
These studies were performed to follow a spectrum of relevant parameters in male Syrian golden hamsters fed either a vitamin A-deficient diet or the same diet supplemented with retinoic acid at 3 micrograms/g diet. Body weight and life span were not affected by the vitamin A-deficient diet until after 6-7 wk. Squamous metaplastic lesions of the Formalin-fixed tracheas were not generally observed in the hamsters fed the deficient diet until 6-7 wk, at which time blood retinol and liver retinyl palmitate levels had also decreased. Blood glucose levels remained normal (90 mg/dl) until about 7 wk but declined to about 40% of normal at 9 and 10 wk. Dietary retinoic acid supplementation of the vitamin-deficient diet (3 micrograms/g diet) inhibited the loss of retinol from blood and of retinyl palmitate from the liver so that these compounds were still present at 10 wk, but were not detectable in hamsters fed the vitamin A-deficient diet without retinoic acid.
Shankar
S
S
Differentiation Control Section, National Cancer Institute, Bethesda, MD 20892.
De Luca
L M
LM
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D006224:Cricetinae; D004032:Diet; D004224:Diterpenes; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D006128:Growth / Q000187:drug effects; D008017:Life Expectancy; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D008679:Metaplasia / Q000209:etiology; D000084562:Retinyl Esters; D014132:Trachea / Q000187:drug effects / Q000473:pathology; D014212:Tretinoin / Q000627:therapeutic use*; D014801:Vitamin A / Q000031:analogs & derivatives / Q000378:metabolism*; D014802:Vitamin A Deficiency / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
D001786:Blood Glucose; D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; D014212:Tretinoin