[A case report of advanced ovarian cancer with chronic renal dysfunction treated by CDDP i.p].
Reported in this paper is a case of a 56-year-old female patient who was diagnosed as having an ovarian cancer (stage T 4) with a renal dysfunction (CCr 30.5 ml/min). We instilled CDDP intra-peritoneally (CDDP-ip), taking into consideration the peritoneal clearance (CLp.). The administration of sodium thiosulphate also was combined. The low CLp. of this case (299.2 ml/h) made it possible to instill a high dose in the peritoneal cavity and a low dose in the plasma. This method provided enough of anti-tumor effect and kept the renal function safe. We believe that the CLp. is the most important factor in determining the effect and side effects of CDDp-ip.
Maruyama
M
M
Dept. of Obstetrics & Gynecology, Nara Medical Univ.
Noda
T
T
Kiyozuka
Y
Y
Oku
M
M
Ninomiya
Y
Y
Ibaraki
T
T
Katoh
Y
Y
Itani
Y
Y
Okamura
Y
Y
Beppu
K
K
D002945:Cisplatin / Q000008:administration & dosage* / Q000097:blood; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007267:Injections; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D010529:Peritoneal Cavity; D013885:Thiosulfates / Q000008:administration & dosage
D013885:Thiosulfates; C017717:sodium thiosulfate; D002945:Cisplatin