title: [Methodological aspects of an experimental multifactorial study of the combined use of antibiotics and immunomodulators].
abstract: Methodological approaches to investigation of the protective effect of natural immunomodulators are described. The use of multifactorial experiment design, a model of infectious processes and immunomodulators alone or in combination with antibiotics is implied. Theoretical preconditions for rational choosing of the experimental factors and their levels, as well as specific designs are discussed. Potentialities of polynomial statistic model analysis in development of optimal regimens for combined chemoimmunotherapy are shown.
authors: A V
authors: AV
authors: Nikitin
authors: V M
authors: VM
authors: Fishman
authors: A N
authors: AN
authors: Lobuseva
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy; D002177:Candidiasis / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004359:Drug Therapy, Combination; D005163:Factor Analysis, Statistical; D008954:Models, Biological; D012107:Research Design; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents
vernacular_title: Metodicheskie aspekty éksperimental'nogo mnogofaktornogo izucheniia kombinirovannogo primeneniia antibiotikov i immunomoduliatorov.