Nonionic block polymer surfactants enhance immunogenicity of pneumococcal hexasaccharide-protein vaccines.
Incorporated in oil-in-water emulsions, nonionic block polymer surfactants change the kinetics of generated antibody responses against pneumococcal hexasaccharide-protein conjugates: prolonged immunoglobulin M and immunoglobulin G responses are realized. Nonionic block polymer surfactants favor the immunogenicity of hexasaccharide-protein conjugates in young mice in such a way that a single injection yields long-lasting protection.
Zigterman
G J
GJ
Department of Immunology, State University of Utrecht, The Netherlands.
Snippe
H
H
Jansze
M
M
Ernste
E B
EB
De Reuver
M J
MJ
Willers
J M
JM
D000276:Adjuvants, Immunologic; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001428:Bacterial Vaccines / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D051379:Mice; D011108:Polymers / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology*; D013501:Surface-Active Agents / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011108:Polymers; D011135:Polysaccharides, Bacterial; D013501:Surface-Active Agents