An analytical study of eight medicinal 2-imidazolines by 1H and 13C nuclear magnetic resonance spectroscopy.
Proton and carbon-13 NMR spectra of eight 2-substituted imidazolines of pharmaceutical interest are presented as solutes in DMSO-d6 together with certain protonation effects. The acidity of the linking methylene group and hydrogen bonding phenomena of the compounds have been also investigated. The data are analysed in terms of analytical utility and the detection of electronic perturbation around specific hydrogen and carbon atoms.
Kountourellis
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Section of Pharmaceutical Analysis, School of Pharmacy and Pharmacology, University of Bath, U.K.
D004121:Dimethyl Sulfoxide; D007093:Imidazoles / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy
D007093:Imidazoles; D004121:Dimethyl Sulfoxide