title: Chronic solar radiation exposure and endothelial polymegethism.
abstract: Acute exposure of ultraviolet radiation to the cornea has previously been shown to produce endothelial pleomorphism and polymegethism. The reciprocity of exposure intensity and duration typically seen with the photochemical effects of ultraviolet radiation on biological tissue predicts a similar effect with chronic exposure. This was tested by comparing the regularity of the hexagonal endothelial mosaic for a group of workers (n = 9) chronically exposed to solar radiation to that for an age-matched control group (n = 18). Although the mean cell area of the endothelium was similar between groups (p greater than 0.10), a significant difference (p less than 0.01) was demonstrated in the degree of polymegethism. This supports the contention that chronic ultraviolet radiation exposure may contribute to increased polymegethism seen with age.
authors: College of Optometry, Ohio State University, Columbus 43210.
authors: G W
authors: GW
authors: Good
authors: J P
authors: JP
authors: Schoessler
mesh_terms: D000328:Adult; D000367:Age Factors; D004728:Endothelium, Corneal / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D013472:Sunlight / Q000009:adverse effects*; D013997:Time Factors