title: MP17, a fiber-specific intrinsic membrane protein from mammalian eye lens.
abstract: A major protein with a molecular weight of 17,000, designated as MP17, has been identified in mammalian eye lens plasma membranes. Hydrophobic photolabeling experiments revealed that MP17 is a genuine intrinsic membrane protein. By using monoclonal antibodies we demonstrated that MP17 is not detectable in liver, heart, muscle, spleen and kidney, and thus can be considered, like MP26, as a lens-specific membrane protein. Furthermore, we showed that MP17 is a substrate for cAMP-dependent protein kinase and that it is a calmodulin-binding protein.
authors: Department of Biochemistry, University of Nijmegen, The Netherlands.
authors: J W
authors: JW
authors: Mulders
authors: C E
authors: CE
authors: Voorter
authors: C
authors: C
authors: Lamers
authors: W A
authors: WA
authors: de Haard-Hoekman
authors: C
authors: C
authors: Montecucco
authors: W J
authors: WJ
authors: van de Ven
authors: H
authors: H
authors: Bloemendal
authors: W W
authors: WW
authors: de Jong
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D002147:Calmodulin / Q000378:metabolism; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D003459:Crystallins / Q000378:metabolism; D005136:Eye Proteins / Q000378:metabolism*; D007908:Lens, Crystalline / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D014176:Protein Biosynthesis; D011494:Protein Kinases / Q000096:biosynthesis
chemical_list: D000911:Antibodies, Monoclonal; D002147:Calmodulin; D003459:Crystallins; D005136:Eye Proteins; D008565:Membrane Proteins; C055948:lens intrinsic protein MP 17; D011494:Protein Kinases