title: [Intraosseous metastasis of malignant tumors (microangiographic study)].
abstract: The vascular factor in intraosseous metastasizing of malignant tumors has been studied insufficiently. The present study consisted in intravital microangiography of random bred albino rats after intraosseous implantation of sarcoma-45. Tumor development resulted in destructive changes in the zone of implantation and then in metastasis to the proximal metaphysis of a bone. Intraosseous tumor cell transfer was noted in the venous blood stream; tumor development beyond the bone occurred in the haversian and Volkmann's canals. It has been established that local readjustment of the blood vessels and three-zonal rearrangement of the blood circulation in the zone of implantation play a major role in the mechanism of intraosseous metastasis of malignant tumors.
authors: S A
authors: SA
authors: Mirzamamedov
mesh_terms: D000792:Angiography; D000818:Animals; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D001842:Bone and Bones / Q000098:blood supply; D008833:Microcirculation / Q000000981:diagnostic imaging; D051381:Rats; D012513:Sarcoma, Experimental / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*
vernacular_title: Vnutrikostnoe metastazirovanie zlokachestvennykh opukholeĭ (mikroangiograficheskoe issledovanie).