[Pharmacokinetic and clinical studies on ceftriaxone in the perinatal period].
Ceftriaxone (CTRX), a new cephalosporin antibiotic, was studied for its pharmacokinetic features and clinical efficacy in the perinatal period and the obtained results are summarized below. 1. Following a one shot intravenous injection of 1 g of CTRX into each of 29 parturient women, CTRX levels were between 4.5 and 19.5 micrograms/ml at 6 hours postdose and between 4.5 and 4.7 micrograms/ml at 24 hours postdose in the amniotic fluid and between 11.7 and 22.7 micrograms/ml at 6 hours postdose and between 4.5 and 4.7 micrograms/ml at 24 hours postdose in the umbilical cord serum. It was shown that CTRX was maintained there at high levels for a long time and the transfer of CTRX into the umbilical cord serum was better than that of other antibiotics. 2. Following a one shot intravenous injection of 1 g of CTRX into each of 12 cases of puerpera, CTRX was detected in the mother's milk until 10 hours postdose, though at a very low level averaging 0.32 to 0.79 microgram/ml. It was considered, however, that CTRX affected little infants through the mother's milk. 3. CTRX was evaluated to be very effective in 2, effective in 5 and ineffective in 1, of 8 cases of infections during the perinatal period. From the above results, CTRX appeared to be effective against infections during the perinatal period.
Hirabayashi
K
K
Department of Obstetrics and Gynecology, Fukuyama National Hospital.
Okada
E
E
D000653:Amniotic Fluid / Q000378:metabolism*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004716:Endometritis / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D008895:Milk, Human / Q000378:metabolism*; D011247:Pregnancy; D011645:Puerperal Infection / Q000188:drug therapy* / Q000378:metabolism
D002443:Ceftriaxone