Effect of chemotherapy on tear drop poikilocytes and other peripheral blood findings in myelofibrosis.
A leukoerythroblastic blood picture and tear drop shaped red cells are two characteristic features of myelofibrosis (MF). Following our earlier observation of an increase in the hemoglobin level with chemotherapy, we have now reviewed the pre- and post-treatment peripheral blood smears from 14 patients with MF to assess the effect of treatment on the above mentioned peripheral blood features. Our results suggest that these features are reversible with effective chemotherapy.
Manoharan
A
A
Department of Clinical Haematology, St George Hospital, University of New South Wales, Sydney.
Hargrave
M
M
Gordon
S
S
D000368:Aged; D000369:Aged, 80 and over; D000493:Allopurinol / Q000008:administration & dosage; D002066:Busulfan / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004906:Erythrocyte Count; D004913:Erythrocytes, Abnormal / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000097:blood* / Q000188:drug therapy; D013154:Spleen / Q000187:drug effects / Q000473:pathology
D000493:Allopurinol; D002066:Busulfan