In-111-labeled white blood cell uptake in noninfected closed fracture in humans: prospective study.
Since indium-111 white blood cell (In-111 WBC) scintigraphy is often used to evaluate for osteomyelitis in bone fractures, it is important to know if noninfected fractures have In-111 WBC uptake. Twenty-seven noninfected closed fracture sites in 19 patients were prospectively evaluated with technetium-99m methylene diphosphonate bone scintigraphy and In-111 WBC scintigraphy. In-111 WBC uptake was present in 41% of the 27 sites. In the 11 positive sites, the In-111 WBC uptake was 1+ (definite but minimal) in 55%, 2+ (moderate) in 36%, and 3+ (marked) in 9%. The visual intensity of the radioactive uptake on In-111 WBC scintigrams relative to that on bone scintigrams was less in 82%, equal in 9%, and greater in 9%. The visual size of the area of uptake on In-111 WBC scintigrams and bone scintigrams was smaller in 36%, equal in 55%, and greater in 9%. Factors that may help distinction of In-111 WBC uptake due to fracture alone from infection associated with fracture are discussed.
Van Nostrand
D
D
Nuclear Medicine Service, Walter Reed Army Medical Center, Uniformed Services University of Health Sciences, Washington, D.C.
Abreu
S H
SH
Callaghan
J J
JJ
Atkins
F B
FB
Stoops
H C
HC
Savory
C G
CG
D000328:Adult; D000368:Aged; D005596:Fractures, Closed / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D007205:Indium Radioisotopes; D007962:Leukocytes; D008875:Middle Aged; D010019:Osteomyelitis / Q000150:complications / Q000000981:diagnostic imaging; D011446:Prospective Studies; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate
D007205:Indium Radioisotopes; D013669:Technetium Tc 99m Medronate