Choreoathetosis induced by ordinary phenytoin levels, explained by high free fraction?--A case report.
Choreoathetosis was induced by phenytoin therapy in an 81-year-old epileptic woman. The plasma concentration of phenytoin was 59 to 80 mumol/L when side effects appeared. Choreoathetosis at ordinary plasma levels has previously been attributed to a preexisting brain damage. In this case, however, it may be explained by a high free fraction (19%) of the phenytoin plasma concentration.
Tomson
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Department of Neurology, Söder Hospital, Stockholm, Sweden.
D000368:Aged; D000369:Aged, 80 and over; D001264:Athetosis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D010672:Phenytoin / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D012640:Seizures / Q000150:complications / Q000188:drug therapy
D010672:Phenytoin