title: Prolongation of luteal lifespan in cows by intrauterine infusion of recombinant bovine alpha-interferon.
abstract: The infusion of recombinant bovine interferon-alpha I 1 into the uterus of cyclic cows from day 15.5 to 21 after estrus delayed luteolysis. Interferon-treated cows had a mean inter-estrous interval of 26.8 +/- 1.39 d, a length that was longer (P less than 0.02) than the inter-estrous interval for control cows (22.8 +/- 0.80 d). Measurements of circulating concentrations of progesterone confirmed that the longer inter-estrous intervals were due to an increase in corpus luteum lifespan following treatment with interferon. These results support the hypothesis that an alpha-interferon-like molecule could play a major role in establishment of pregnancy in cattle.
authors: Dairy Sciences Department, University of Florida, Gainesville 32611.
authors: C
authors: C
authors: Plante
authors: P J
authors: PJ
authors: Hansen
authors: W W
authors: WW
authors: Thatcher
mesh_terms: D000818:Animals; D002417:Cattle; D003338:Corpus Luteum / Q000187:drug effects / Q000502:physiology*; D004971:Estrus / Q000187:drug effects; D005260:Female; D007263:Infusions, Parenteral; D007370:Interferon Type I / Q000008:administration & dosage / Q000502:physiology*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D012016:Reference Values; D014599:Uterus
chemical_list: D007370:Interferon Type I; D011994:Recombinant Proteins