[An application of a new antibiotic, ceftriaxone, during the perinatal period].
1. Ceftriaxone (CTRX) was not transferred well into cerebrospinal fluid in healthy individuals. 2. The transplacental passage and the transfer of CTRX into amniotic fluid were very good, and CTRX seems useful for the treatment of perinatal infections. 3. Clinically, CTRX was very effective against amniotic infections and infections of the puerperal uterus: Clinical efficacies were excellent in 1 case and good in 3 out of 4 cases (efficacy rate: 100%). 4. No side effects or laboratory abnormalities were observed.
Tateno
M
M
Department of Obstetrics and Gynecology, Toyama Prefectural Central Hospital.
D000653:Amniotic Fluid / Q000378:metabolism; D002443:Ceftriaxone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002555:Cerebrospinal Fluid / Q000378:metabolism; D004716:Endometritis / Q000188:drug therapy*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005865:Gestational Age; D006801:Humans; D007262:Infusions, Intravenous; D011247:Pregnancy; D011645:Puerperal Infection / Q000188:drug therapy*
D002443:Ceftriaxone