[Cell growth and differentiation of cerebellar organotypical culture of rat embryos exposed to microgravity].
Cerebellar cells of 18-day rat fetuses that developed for 5 days on Cosmos-1514 and those of synchronous and vivarium controls were cultivated for 21 days in Maximov chambers. Light microscopic examinations of live explants and semithin sections revealed no disorders in histotypical structures of explants or cytopathological changes in Purkinje cells and granule cells. It is concluded that space flight effects on the cerebellar morphogenesis of rat fetuses exposed to microgravity during days 13 to 18 of their prenatal development did not lead to such changes in the differentiation of nerve and glia cells which would cause morphogenetic disorders during postflight organotypical cultivation.
Viktorov
I V
IV
Shashkova
N A
NA
Priva
A
A
Drian
M J
MJ
D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology / Q000196:embryology*; D005260:Female; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013026:Space Flight; D014893:Weightlessness
Rost i differentsirovka kletok v organotipicheskoĭ kult'ture mozzhechka krysinykh émbrionov, razvivavshikhsia v nevosomosti.