Androgenic control of acetate incorporation into membrane lipids in rat ventral prostate.
The rat ventral prostate plasma membranes incorporated acetate into total lipids, which was a time-dependent process. The acetate incorporation was mainly into phospholipids followed by cholesterol. The main phospholipids subclasses were choline and ethanolamine glycerophospholipids. Castration modified drastically both cholesterol-phospholipids and choline glycerophospholipids-ethanolamine glycerophospholipids ratios. These effects of castration were reversed after testosterone treatment, which could suggest an influence of this hormone in the modification of some lipid classes into cellular membrane.
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Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá de Henares, Madrid, Spain.
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Pérez-Albarsanz
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D000085:Acetates / Q000378:metabolism*; D000728:Androgens / Q000502:physiology*; D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis; D008297:Male; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000096:biosynthesis*; D009919:Orchiectomy; D010743:Phospholipids / Q000096:biosynthesis; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology
D000085:Acetates; D000728:Androgens; D008563:Membrane Lipids; D010743:Phospholipids; D013739:Testosterone; D002784:Cholesterol