The role of staphylococcal lectins in human granulocyte stimulation.
The anti-staphylococcal activity spectrum of human polymorphonuclear leucocytes (PMN) is widely ranged. Using chemiluminescence measurements, the opsonin-independent stimulation of PMNs from eight healthy humans towards two Staphylococcus saprophyticus strains (S 1 and S 35) was investigated. Strain S 1 was shown to have surface lectins with N-acetylgalactosamine specificity, whereas strain S 35 had N-acetyl-neuraminic acid specificity. Three different PMN-reaction patterns could be demonstrated: PMN stimulation was either sensitive to N-acetylgalactosamine-or N-acetylneuraminic acid-blocking, or resistant to both. These results point to the importance of lectins for staphylococcal-PMN interactions.
Beuth
J
J
Institut für Hygiene, Universität Köln.
Ko
H L
HL
Pulverer
G
G
D000116:Acetylgalactosamine / Q000378:metabolism; D006386:Hemagglutination Tests; D006801:Humans; D037102:Lectins / Q000494:pharmacology*; D008163:Luminescent Measurements; D019158:N-Acetylneuraminic Acid; D009504:Neutrophils / Q000187:drug effects*; D012794:Sialic Acids / Q000378:metabolism; D013210:Staphylococcus / Q000032:analysis*
D037102:Lectins; D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid; D000116:Acetylgalactosamine