Isomers of 10-hydroxynortriptyline in geriatric depression.
In geriatric, depressed inpatients treated with nortriptyline (NT), total unconjugated plasma concentrations of the Z isomer of the 10-hydroxylated metabolite (10-OH-NT) were determined simultaneously with concentrations of the E isomer by high-performance liquid chromatography. Z-10-OH-NT concentrations averaged 14% of E-10-OH-NT concentrations.
Young
R C
RC
Department of Psychiatry, New York Hospital-Cornell Medical Center, White Plains 10605.
Dhar
A K
AK
Kutt
H
H
Alexopoulos
G S
GS
D000368:Aged; D002851:Chromatography, High Pressure Liquid; D003866:Depressive Disorder / Q000188:drug therapy*; D006801:Humans; D007536:Isomerism; D008875:Middle Aged; D009661:Nortriptyline / Q000031:analogs & derivatives* / Q000627:therapeutic use
C013567:10-hydroxynortriptyline; D009661:Nortriptyline