[Effectiveness of propranolol in an acute test and a course of treatment in patients with stenocardia].
A comparative study of antianginal propranolol efficacy in an acute test and 7 days after regular therapy in patients with a stable form of angina of effort has shown that the duration of beta-blockade and antianginal action of the drug increases during course therapy at individual doses in a 3-4-fold regimen of administration. Sharp reduction of a degree of the antianginal effect of propranolol was noted almost in 42% of the patients on regular therapy which could be accounted for by an increase in beta-blocker negative inotropic action. In the group of patients in whom propranolol antianginal efficacy was on a decrease during course therapy, not a single clinical or hemodynamic sign was defined permitting the prediction of a reduced effect of propranolol during course therapy.
Savvateev
K L
KL
Desiatnichenko
V M
VM
Romakov
A Iu
AIu
Mazur
N A
NA
D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005080:Exercise Test; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D011433:Propranolol / Q000008:administration & dosage*; D013997:Time Factors
D011433:Propranolol
Effektivnost' propranolola v ostroĭ probe i pri kursovom lechenii u bol'nykh stenokardieĭ.