cis-Halovinylthioacetamido side chain, a new effective structural element for 7 beta-substitution in cephem and oxacephem antibiotics. II. 7 beta-cis-Fluorovinylthioacetamino-7 alpha-methoxy-1-oxacephems.
The synthesis and in vitro activity of 1-oxacephem derivatives having a substituted or a non-substituted cis-fluorovinylthioacetamido side chain at C-7 are described. Of these new 1-oxacephem antibiotics, 2355-S (42a) shows good antibacterial activity against Gram-positive and Gram-negative bacteria, and very favorable pharmacokinetic properties.
Nishitani
Y
Y
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Aoki
T
T
Konoike
T
T
Takahashi
H
H
Yamamoto
S
S
Nishino
Y
Y
Yoshioka
M
M
Tsuji
T
T
Komatsu
Y
Y
Matsuura
S
S
D008826:Microbial Sensitivity Tests; D009070:Moxalactam / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D009070:Moxalactam