title: Reduced parasitemia observed with erythrocytes containing inositol hexaphosphate.
abstract: Chemicals entrapped in erythrocytes by hypotonic hemolysis can be assessed for possible antiparasitic activity both in vivo and in vitro, regardless of whether they are able to diffuse into erythrocytes readily. Inositol hexaphosphate, a highly charged compound, produced a dramatic lowering of the percentage of cells infected by Babesia microti in vivo and both B. microti and Plasmodium falciparum in vitro. Several possible mechanisms for this observation are discussed.
authors: Department of Medical Biochemistry and Genetics, Texas A & M College of Medicine, College Station.
authors: C L
authors: CL
authors: Mintzer
authors: P
authors: P
authors: Deloron
authors: A
authors: A
authors: Rice-Ficht
authors: D
authors: D
authors: Durica
authors: D K
authors: DK
authors: Struck
authors: C A
authors: CA
authors: Roessner
authors: C
authors: C
authors: Nicolau
authors: G M
authors: GM
authors: Ihler
mesh_terms: D000818:Animals; D001404:Babesiosis / Q000097:blood; D004912:Erythrocytes / Q000469:parasitology*; D006461:Hemolysis; D066298:In Vitro Techniques; D008288:Malaria / Q000097:blood; D051379:Mice; D008807:Mice, Inbred BALB C; D010833:Phytic Acid / Q000494:pharmacology*
chemical_list: D010833:Phytic Acid