Evaluation of the effects of sennosides on uterine motility in the pregnant ewe.
The effects of sennosides on uterine motility were evaluated by electromyography in healthy adult ewes between day 70 and 120 of pregnancy to assess possible disturbances of the physiological pattern of contractility and eventual risks in pregnancy maintenance. At this stage of pregnancy, the ovine genital tract presented motility episodes of 6-8 min duration occurring at approximately hourly intervals. A dose-range study (10-160 mg/kg intracolonically) in 2 ewes showed that diarrhea was systematically obtained with doses greater than 20 mg/kg and was connected with a marked depression of both ileum and spiral colon motility. A standard dose of 60 mg/kg administered intracolonically 1-3 times at 7- to 10-day intervals to 12 ewes was used in the uterus studies. The experiments showed that sennosides did not stimulate uterine motility in the pregnant ewe, but slightly depressed it in some ewes. Cervix motility was never influenced. Intolerance of the drug was observed in half of the animals resulting mainly in anorexia or weakness and confirming a specific toxicity of senna in ruminants which is not known from other species. These effects were not related to uterine motility and pregnancy maintenance was normal in all ewes.
Garcia-Villar
R
R
Department of Pharmacology-Toxicology, INRA, Toulouse, France.
D000818:Animals; D000880:Anthraquinones / Q000633:toxicity*; D002400:Cathartics / Q000633:toxicity; D002584:Cervix Uteri / Q000187:drug effects; D004361:Drug Tolerance; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D011247:Pregnancy; D011255:Pregnancy Maintenance / Q000187:drug effects; D012676:Senna Extract; D000081226:Sennosides; D012756:Sheep; D014590:Uterine Contraction / Q000187:drug effects*
D000880:Anthraquinones; D002400:Cathartics; D000081226:Sennosides; D012676:Senna Extract