Difference of bone marrow adipocyte colony-forming capacity between aplastic anemia and iron deficiency anemia.
The bone marrow adipocyte colony-forming capacity (Adipo-CFC) in patients with aplastic anemia (AA), myelodysplastic syndrome (MDS) and iron deficiency anemia (IDA) was studied. Before treatment, Adipo-CFC in IDA was higher than that in AA and MDS. After treatment, Adipo-CFC decreased in IDA, but it increased in AA and MDS only at the responsive stage. In this context, it is suggested that increase of Adipo-CFC occurs during not only regenerating hemopoiesis but also accelerated erythropoiesis such as severe IDA. Colony-stimulating activity (CSA) production by marrow stromal cells (MSC) in AA was lower than that in normal subjects. Low Adipo-CFC and defective CSA production by MSC may explain in part the pathogenesis of microenvironmental defect in AA.
Hirata
J
J
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Umemura
T
T
Kaneko
S
S
Nishimura
J
J
Motomura
S
S
Ibayashi
H
H
D000273:Adipose Tissue / Q000473:pathology*; D000741:Anemia, Aplastic / Q000473:pathology*; D000747:Anemia, Hypochromic / Q000473:pathology*; D000753:Anemia, Refractory / Q000473:pathology*; D000754:Anemia, Refractory, with Excess of Blasts / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology*; D003114:Colony-Forming Units Assay; D006801:Humans