title: Some adverse reactions to allopurinol may be mediated by lymphocyte reactivity to oxypurinol.
abstract: Six of 9 patients with previously documented adverse reactions to allopurinol exhibited transformation of their peripheral blood lymphocytes when these were exposed in vitro to the allopurinol metabolite, oxypurinol. In 2 of these subjects, intradermal skin challenge was positive at 48 hours with either allopurinol or oxypurinol. The evidence presented suggests that some adverse reactions to allopurinol represent delayed-type hypersensitivity to oxypurinol.
authors: Department of Medicine, Princess Alexandra Hospital, University of Queensland, Brisbane, Australia.
authors: B T
authors: BT
authors: Emmerson
authors: R A
authors: RA
authors: Hazelton
authors: I H
authors: IH
authors: Frazer
mesh_terms: D000493:Allopurinol / Q000009:adverse effects*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D010117:Oxypurinol / Q000276:immunology*; D011743:Pyrimidines / Q000276:immunology*; D012882:Skin Tests
chemical_list: D011743:Pyrimidines; D000493:Allopurinol; D010117:Oxypurinol