title: [Intracavernous injection of vasoactive substances in the treatment of erectile dysfunction].
abstract: Herein we report our experience with a clinical trial of intracavernous injection of vasoactive substances (Papaverin, Dibenzyran, Regitin) in 41 patients suffering from erectile dysfunction for longer than 1 year. In 14 out of 33 patients the application of papaverin alone was already sufficient to produce an excellent erection (T/E-grade 4) under clinical conditions. The simultaneous injection of two agents (Papaverin + Dibenzyran or Papaverin + Regitin) in patients with no or insufficient response to papaverin improved the results additionally. Besides a positively effect of delay from the injection to the erection could be observed in comparison with an injection of only papaverin. In conclusion, this method combined with an autoinjection therapy is an alternative approach to treat certain patients with erectile dysfunction.
authors: Klinik für Urologie, Medizinischen Akademie, Carl Gustav Carus, Dresden.
authors: J
authors: J
authors: Wehnert
authors: J
authors: J
authors: Kramer
authors: J
authors: J
authors: Weller
authors: S
authors: S
authors: Leike
mesh_terms: D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000008:administration & dosage*; D010410:Penile Erection / Q000187:drug effects*; D010643:Phenoxybenzamine / Q000008:administration & dosage; D010646:Phentolamine / Q000008:administration & dosage; D010865:Pilot Projects
chemical_list: D010643:Phenoxybenzamine; D010208:Papaverine; D010646:Phentolamine
vernacular_title: Intracavernöse Injektion vasoaktiver Substanzen zur Behandlung der erektilen Dysfunktion.