title: Large-scale resolution of gossypol enantiomers for biological evaluation.
abstract: Gossypol has been resolved into its pure optical isomers by conversion into the Schiff's base derivative of (+)-phenylalanine methyl ester, normal or reverse phase chromatography and hydrolysis. Forty grams of pure (-)-gossypol has been prepared in a micronised form for assessment of its antifertility and toxicological effects.
authors: Chemistry Department, The City University, London, UK.
authors: S A
authors: SA
authors: Matlin
authors: R H
authors: RH
authors: Zhou
authors: A
authors: A
authors: Belenguer
authors: R G
authors: RG
authors: Tyson
authors: A N
authors: AN
authors: Brookes
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D005298:Fertility / Q000187:drug effects*; D006072:Gossypol / Q000032:analysis* / Q000494:pharmacology; D007536:Isomerism; D008297:Male; D008647:Mesocricetus; D012545:Schiff Bases / Q000138:chemical synthesis
chemical_list: D012545:Schiff Bases; D006072:Gossypol