title: Hypogonadism in liver cirrhosis: implication in altered amino acid metabolism in muscle.
abstract: To investigate the relationship between hypogonadism and altered amino acid metabolism in patients with liver cirrhosis, we measured the basal levels of plasma testosterone, estradiol, and free amino acids, plus urinary 3-methylhistidine excretion, in 16 control and 19 cirrhotic patients. The concentration of plasma testosterone correlated significantly with that of plasma branched-chain amino acids, and inversely with urinary 3-methylhistidine excretion. This suggests that hypogonadism causes a disturbance in amino acid metabolism at least partly related to an augmented muscle protein turnover.
authors: Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
authors: T
authors: T
authors: Hori
authors: Y
authors: Y
authors: Murawaki
authors: C
authors: C
authors: Hirayama
mesh_terms: D000596:Amino Acids / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007006:Hypogonadism / Q000209:etiology* / Q000378:metabolism; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism*; D008297:Male; D008762:Methylhistidines / Q000097:blood; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D013739:Testosterone / Q000097:blood
chemical_list: D000596:Amino Acids; D008762:Methylhistidines; D013739:Testosterone