Involvement of uptake2 mechanism in inactivation of noradrenaline released by tyramine under anoxic conditions in perfused rat heart.
Effects of uptake2 inhibition by corticosterone on tyramine-induced noradrenaline (NA) overflow under control, glucose-deprivation, anoxia and anoxia with glucose-deprivation were examined in perfused rat heart. Uptake2 inhibition by corticosterone (100 microM) had no effect on the NA overflow under control and glucose-deprivation, but significantly augmented the NA overflow by about 40% and 25% under anoxia and anoxia with glucose-deprivation, respectively. These results indicate that the uptake mechanism is at least in part responsible for the inactivation of NA under anoxic conditions in the perfused rat heart.
Inoue
M
M
Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan.
Hifumi
K
K
Kurahashi
K
K
Fujiwara
M
M
D000818:Animals; D003345:Corticosterone / Q000494:pharmacology*; D005947:Glucose / Q000502:physiology; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000037:antagonists & inhibitors*; D010100:Oxygen / Q000494:pharmacology*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D014439:Tyramine / Q000494:pharmacology*
D005947:Glucose; D010100:Oxygen; D003345:Corticosterone; D009638:Norepinephrine; D014439:Tyramine