title: Effect of hypertension and physical training on the morphology of the kidney with special reference to the juxtaglomerular cells.
abstract: Changes in blood pressure levels, renal structure and degree of granulation of the juxtaglomerular cells in Dahl S rats fed a normal or high salt diet are reported. The effect of physical training on the hypertensive state of these animals has also been described. Animals fed a high salt diet demonstrated increased blood pressure levels and decreased juxtaglomerular indices when compared with rats fed a normal diet. The extent of renal damage in these animals was observed to be proportional to the amount of sodium in the diet. Physical training, however, brought about a 15-25% reduction in blood pressure levels and decreased renal damage in Dahl S rats fed a normal or high salt diet. The mean juxtaglomerular index was observed to be 30% higher in trained animals fed a normal diet compared with non-trained controls. It is concluded that physical training helps minimize pathological changes in the kidney and effects a reduction in blood pressure levels in hypertensive Dahl S rats.
authors: School of Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
authors: J
authors: J
authors: Anthony
authors: M
authors: M
authors: Savage
mesh_terms: D000818:Animals; D001158:Arteries / Q000473:pathology; D001794:Blood Pressure; D006973:Hypertension / Q000473:pathology*; D007606:Juxtaglomerular Apparatus / Q000098:blood supply / Q000166:cytology / Q000473:pathology*; D007668:Kidney / Q000166:cytology / Q000473:pathology*; D008297:Male; D009336:Necrosis; D005082:Physical Exertion; D051381:Rats; D011918:Rats, Inbred SHR; D012982:Sodium, Dietary
chemical_list: D012982:Sodium, Dietary