title: Fatal disseminated cryptococcosis following intraocular involvement.
abstract: A 33-year-old man was treated with systemic steroids for a retinal inflammatory lesion before the diagnosis of cryptococcal retinitis and meningitis was suspected. He died from central nervous system disease despite treatment with parenteral antifungals. Histopathological studies demonstrated ocular and disseminated systemic infection with Cryptococcus neoformans. Direct cryptococcal involvement of the eye is rare and is usually associated with disseminated disease. Systemic steroids must be used with caution, and patients who take these drugs require frequent monitoring.
authors: Department of Ophthalmology, University of Texas Medical Branch, Galveston 77550.
authors: J A
authors: JA
authors: Schulman
authors: C
authors: C
authors: Leveque
authors: M
authors: M
authors: Coats
authors: L
authors: L
authors: Lawrence
authors: J C
authors: JC
authors: Barber
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D003453:Cryptococcosis / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D005437:Flucytosine / Q000627:therapeutic use; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008581:Meningitis / Q000175:diagnosis / Q000209:etiology*; D011241:Prednisone / Q000009:adverse effects; D012160:Retina / Q000473:pathology; D012173:Retinitis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology
chemical_list: D000666:Amphotericin B; D005437:Flucytosine; D011241:Prednisone