Blood brain barrier in ageing and Alzheimer's disease.
A blood-brain barrier deficit may play a role in age-related deterioration and neurodegenerative diseases of the central nervous system. Strategies for testing this hypothesis by investigating the structure, barrier and transport functions of brain capillary endothelium are described and discussed.
Davies
D C
DC
Department of Anatomy and Cell Biology, St. Mary's Hospital Medical School, Paddington, London, UK.
Hardy
J A
JA
D000368:Aged; D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000503:physiopathology*; D000818:Animals; D001812:Blood-Brain Barrier; D002196:Capillaries / Q000033:anatomy & histology / Q000648:ultrastructure; D002352:Carrier Proteins / Q000378:metabolism; D002560:Cerebrovascular Circulation; D004730:Endothelium, Vascular / Q000166:cytology / Q000648:ultrastructure; D006801:Humans
D002352:Carrier Proteins