title: Some characteristics of fetal and adult isoenzymes of thymidine kinase in human breast cancers.
abstract: Two isoenzymes of Thymidine Kinase were isolated from 90 human breast cancers by ion exchange chromatography. One was the enzyme present in adult tissues (TK-A), the second corresponded with the enzyme found in fetal tissues (TK-F). The presence of both isoenzymes was observed in the 90 tumors investigated. The activity of TK-A varied in the same range as in normal tissues, while the activity of TK-F varied to a larger extent and was higher than that of TK-A in a majority of tumors. Moreover, TK-F activity was independent of the presence or of the level of estradiol and progesterone receptors. Both isoenzymes were further characterized and compared.
authors: Centre régional de recherche en endocrinologie, Faculté de Médecine-Pharmacie, Rennes, France.
authors: A
authors: A
authors: Madec
authors: J L
authors: JL
authors: Javre
authors: D
authors: D
authors: Haras
authors: S
authors: S
authors: Samperez
authors: P
authors: P
authors: Jouan
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology*; D000328:Adult; D001943:Breast Neoplasms / Q000201:enzymology*; D005260:Female; D005333:Fetus / Q000201:enzymology*; D006801:Humans; D007527:Isoenzymes / Q000302:isolation & purification / Q000378:metabolism*; D013937:Thymidine Kinase / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D013937:Thymidine Kinase