[Effect of the chemical structure of low molecular weight hapten carriers on immunoreactivity].
Patients with demonstrated contact dermatitis to DNCB (dinitrochlorobenzene) were patch-tested using various dinitrophenyl (DNP) derivatives. These investigations revealed the varying sensitivities to the structural isomers DNP-L-alpha-alanine (59% positive) and DNP-beta-alanine (4% positive). These results are discussed both in connection with various sensitivity rates to other DNP compounds and published findings from the literature concerning the influence of structural factors on immune reactivity.
Schwartze
G
G
Klinik und Poliklinik für Hautkrankheiten, Bereiches Medizin der Martin-Luther-Universität Halle-Wittenberg.
Lübbe
D
D
Wozniak
K D
KD
D003877:Dermatitis, Contact / Q000276:immunology*; D004137:Dinitrochlorobenzene / Q000276:immunology; D004140:Dinitrophenols / Q000276:immunology*; D006801:Humans; D008970:Molecular Weight; D010328:Patch Tests; D013329:Structure-Activity Relationship
D004137:Dinitrochlorobenzene; D004140:Dinitrophenols
Zum Einfluss der chemischen Struktur niedermolekularer Hapten-Träger auf die Immunreaktivität.