Age-related changes in the kinetics of iron absorption across the guinea pig proximal intestine in vivo.
In the healthy human adult, body iron content is regulated by intestinal iron absorption. However in neonates who are iron replete, iron absorption is inappropriately increased. In this study we have compared the kinetics of iron absorption in the proximal small intestine of the newborn and adult guinea pig in order to gain insight into the cellular mechanisms underlying this difference. Iron uptake was studied in vivo over the concentration range 20-2,000 microM. Total iron uptake could be resolved into saturable and linear components. The kinetic constants for the saturable component in the adult were similar to the neonate. In contrast, the rate of uptake via the linear pathway was 4 times greater in the neonate compared to the adult. It is concluded that the increased absorption of iron by the neonatal guinea pig is due to an enhanced uptake via the linear pathway. In contrast to total iron uptake, we were unable to detect developmental changes in iron transfer into the carcass.
Srai
S K
SK
Department of Medicine, Royal Free Hospital School of Medicine, London, England.
Debnam
E S
ES
Boss
M
M
Epstein
O
O
D000375:Aging / Q000378:metabolism*; D000818:Animals; D006168:Guinea Pigs; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D007501:Iron / Q000493:pharmacokinetics*
D007501:Iron