Effects of triamterene on serum and skeletal muscle electrolytes in diuretic-treated patients.
The effects on plasma and skeletal muscle electrolytes of the combination of triamterene 37.5 mg and hydrochlorothiazide 25 mg daily were studied in 19 patients on prior long-term (greater than 1 year) diuretic therapy for arterial hypertension and/or congestive heart failure. A further 20 patients fulfilling the same admission criteria were used as controls. Blood samples and skeletal muscle biopsies were taken before the study and after 6 months on therapy. The diuretic-treated group had a significant increase in skeletal muscle potassium and magnesium after 6 months on therapy as compared to the controls. Thus, the combination of triamterene and hydrochlorothiazide appeared effective in preserving the cellular content of potassium and magnesium on a long-term basis in the type of patient studied.
Widmann
L
L
Department of Internal Medicine, University of Umeå, Sweden.
Dyckner
T
T
Wester
P O
PO
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001834:Body Water / Q000378:metabolism; D004232:Diuretics / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D011188:Potassium / Q000097:blood / Q000378:metabolism*; D014223:Triamterene / Q000008:administration & dosage / Q000494:pharmacology*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D004232:Diuretics; D008274:Magnesium; D011188:Potassium; D014223:Triamterene