title: Acute visual and auditory neurotoxicity in patients with end-stage renal disease receiving desferrioxamine.
abstract: We report 5 cases of acute visual and auditory neurotoxicity in patients with end-stage renal disease receiving desferrioxamine. Four patients complained of visual toxicity characterized by a decrease in visual acuity, loss of color vision and night blindness. In these patients there was a decrease in visual acuity, and the Farnsworth's test revealed a tritanopy (yellow-blue axis impairment); 1 patient also showed retinal pigmentary changes. A fifth patient complained of bilateral and severe neurosensorial deafness. Patients improved clinically upon drug-withdrawal. We recommend careful monitoring of audiovisual toxicity in patients with end-stage renal disease receiving this drug.
authors: Nephrology Service, Hospital Clínic i Provincial, Barcelona, Spain.
authors: A
authors: A
authors: Cases
authors: J
authors: J
authors: Kelly
authors: J
authors: J
authors: Sabater
authors: J M
authors: JM
authors: Campistol
authors: A
authors: A
authors: Torras
authors: J
authors: J
authors: Montoliu
authors: I
authors: I
authors: López
authors: L
authors: L
authors: Revert
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D003676:Deferoxamine / Q000009:adverse effects*; D005260:Female; D034381:Hearing Loss / Q000139:chemically induced*; D006312:Hearing Loss, Bilateral / Q000139:chemically induced*; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D008875:Middle Aged; D014786:Vision Disorders / Q000139:chemically induced*; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D003676:Deferoxamine