title: Structure of an escape mutant of glycoprotein N2 neuraminidase of influenza virus A/Tokyo/3/67 at 3 A.
abstract: The three-dimensional structure of the membrane glycoprotein neuraminidase of an escape mutant of the influenza virus strain A/Tokyo/3/67 has been determined to 3 A (1 A = 0.1 nm) resolution by X-ray diffraction. The mutant virus, selected by growing the virus in the presence of a monoclonal antibody to the neuraminidase, is shown to have undergone a single amino acid change of lysine to glutamic acid at residue 368. The three-dimensional structure of the neuraminidase is identical with that reported for A/Tokyo/3/67, except for a purely local adjustment of the structure at position 368.
authors: C.S.I.R.O. Division of Protein Chemistry, Parkville, Victoria, Australia.
authors: J N
authors: JN
authors: Varghese
authors: R G
authors: RG
authors: Webster
authors: W G
authors: WG
authors: Laver
authors: P M
authors: PM
authors: Colman
mesh_terms: D000595:Amino Acid Sequence; D009980:Influenza A virus / Q000201:enzymology*; D008562:Membrane Glycoproteins; D009154:Mutation; D009439:Neuraminidase; D014763:Viral Matrix Proteins; D014961:X-Ray Diffraction
chemical_list: D008562:Membrane Glycoproteins; D014763:Viral Matrix Proteins; D009439:Neuraminidase