Effect of flurithromycin, a new macrolide antibiotic, on carbamazepine disposition in normal subjects.
The effects of flurithromycin, a new macrolide antibiotic, on the disposition of a single oral dose of carbamazepine (CBZ) (400 mg) were investigated in seven normal subjects. Flurithromycin (2 x 250 mg thrice daily for 10 days) caused a slight increase in the CBZ area under the serum concentration curve and a moderate reduction in carbamazepine-10, 11-epoxide (CBZ-E) levels. These results suggest that flurithromycin can inhibit the conversion of CBZ to CBZ-E, although, at the dosage tested, the magnitude of this effect was significantly smaller than that observed after administration of erythromycin in the same subjects.
Barzaghi
N
N
Department of Internal Medicine and Therapeutics, University of Pavia, Italy.
Gatti
G
G
Crema
F
F
Faja
A
A
Monteleone
M
M
Amione
C
C
Leone
L
L
Perucca
E
E
D000328:Adult; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D008297:Male
D002220:Carbamazepine; C045925:flurithromycin; D004917:Erythromycin; C012227:carbamazepine epoxide