Potassium and myoglobin release and ST and QRS vector changes during acute myocardial infarction.
Thirty-three consecutive patients aged 39 to 77 years with signs of myocardial infarction with a duration of symptoms of less than 4 h took part in the study. Serial blood sampling was done for the determination of myoglobin (MG), creatine-kinase (CK) and potassium (K). Continuous vectorcardiography was monitored. Peak rates of K and MG release occurred 7.0 +/- 3.7 and 6.5 +/- 3.9 hours, respectively, after the onset of symptoms not different from the end of ST vector change that occurred after 7.6 +/- 2.8 h. Following the end of ST vector change there was a 4-hour delay until the end of QRS vector change and another 8-hour delay to the end of MG release occurring about 20 h after the onset of symptoms. At the time for peak rate of MG release 48 +/- 17% of total MG release had occurred. In conclusion, the physiologically different indicators of myocardial damage showed signs of maximum release within the same time range, 6-8 h after the onset symptoms and 8-10 h before signs of completed infarction.
Sylvén
C
C
Department of Medicine, Danderyd Hospital, Sweden.
Sederholm
M
M
D000328:Adult; D000368:Aged; D003402:Creatine Kinase / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism*; D009211:Myoglobin / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*
D009211:Myoglobin; D003402:Creatine Kinase; D011188:Potassium