title: Efficacy of plasma-sprayed tricalcium phosphate in enhancing the fixation of smooth titanium intramedullary rods.
abstract: The osseous tissue response to intramedullary rods plasma-sprayed with TCP was investigated. TCP-sprayed smooth titanium rods and unsprayed controls were bilaterally implanted into the medullary canals of rabbit tibiae. Rabbits in the short-term study were sacrificed at 3 weeks; rabbits in the long-term study were sacrificed at 12 weeks. Pull-out tests were performed and histological sections prepared. The TCP-sprayed titanium rods exhibited significantly higher pull-out strengths than unsprayed contralateral rods at both 3 and 12 weeks, suggesting the bonding of bone to the TCP layer. The TCP-sprayed titanium rods at 3 weeks showed significantly greater osseous tissue response than unsprayed contralateral controls. At 12 weeks, the osseous tissue response was greater than at 3 weeks, and, surprisingly, the response to TCP-sprayed and unsprayed titanium rods was comparable.
authors: Thayer School of Engineering, Dartmouth College.
authors: J C
authors: JC
authors: Chae
authors: J P
authors: JP
authors: Collier
authors: M B
authors: MB
authors: Mayor
authors: V A
authors: VA
authors: Surprenant
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000601:surgery*; D001842:Bone and Bones / Q000033:anatomy & histology* / Q000502:physiology; D002130:Calcium Phosphates; D010012:Osteogenesis; D019736:Prostheses and Implants; D011817:Rabbits; D013314:Stress, Mechanical; D013499:Surface Properties; D013977:Tibia; D014025:Titanium; D014945:Wound Healing
chemical_list: D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; D014025:Titanium; C485829:calcium phosphate, dibasic, anhydrous