title: Malignant hyperthermia in myotonia congenita.
abstract: We report a family in which two sisters with myotonia congenita (MyC) were referred for malignant hyperthermia (MH) evaluation after each developed muscle rigidity with anesthesia. Halothane contracture testing of skeletal muscle in both was consistent with MH susceptibility. A third sister without clinical evidence of MyC was negative on contracture testing. These results suggest an association between MyC and MH susceptibility.
authors: Department of Neurology, Hahnemann University Hospital, Philadelphia, PA 19102.
authors: T
authors: T
authors: Heiman-Patterson
authors: C
authors: C
authors: Martino
authors: H
authors: H
authors: Rosenberg
authors: J
authors: J
authors: Fletcher
authors: A
authors: A
authors: Tahmoush
mesh_terms: D000328:Adult; D000758:Anesthesia / Q000009:adverse effects; D001706:Biopsy; D005260:Female; D006221:Halothane; D006801:Humans; D008305:Malignant Hyperthermia / Q000150:complications* / Q000235:genetics; D009132:Muscles / Q000473:pathology; D009224:Myotonia Congenita / Q000150:complications* / Q000235:genetics / Q000473:pathology; D013390:Succinylcholine / Q000009:adverse effects
chemical_list: D013390:Succinylcholine; D006221:Halothane