title: Antibodies against native type II collagen do not precede the clinical onset of rheumatoid arthritis.
abstract: Serum levels of IgG and IgM antibodies to native human type II collagen were determined in 22 pre-illness sera from subjects who developed seropositive rheumatoid arthritis (RA) 4 months to 5 years after sera were obtained, in 51 specimens from 35 healthy controls, and in 4-5 specimens from 58 patients with recent-onset RA. The antibody levels in all pre-illness serum specimens fell within the range seen for the healthy controls. Four RA patients had an IgG class antibody level and 4 had an IgM class antibody level that was above the highest level observed for controls, in at least 1 serum sample. No significant difference in the mean level of anticollagen antibodies was observed in the followup specimens from RA patients.
authors: Central Hospital, Jyväskylä, Finland.
authors: T
authors: T
authors: Möttönen
authors: P
authors: P
authors: Hannonen
authors: M
authors: M
authors: Oka
authors: J
authors: J
authors: Rautiainen
authors: I
authors: I
authors: Jokinen
authors: H
authors: H
authors: Arvilommi
authors: T
authors: T
authors: Palosuo
authors: K
authors: K
authors: Aho
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000503:physiopathology; D003094:Collagen / Q000145:classification / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008875:Middle Aged
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003094:Collagen