title: Association of closure of patent ductus arteriosus and development of necrotizing enterocolitis.
abstract: Over a 5-year period ending in June 1986, 234 neonates with evidence of a significant patent ductus arteriosus (PDA) underwent ductal manipulation. Thirty-four infants (15%) developed evidence of necrotizing enterocolitis (NEC). When NEC and treatment of PDA were within 72 hours of each other, there was a 71% mortality rate. When NEC and PDA ligation were greater than 72 hours apart, there were no deaths. Development of NEC prior to ductal closure was associated with a mortality of 57%, as opposed to no mortality when the development of NEC occurred after ductal closure. Our data suggest that infants who develop NEC before PDA ligation incur a high mortality.
authors: Department of Surgery, University of California, Davis, School of Medicine, Sacramento 95817.
authors: S B
authors: SB
authors: Palder
authors: M Z
authors: MZ
authors: Schwartz
authors: K R
authors: KR
authors: Tyson
authors: C C
authors: CC
authors: Marr
mesh_terms: D001724:Birth Weight; D004374:Ductus Arteriosus, Patent / Q000150:complications* / Q000601:surgery; D004761:Enterocolitis, Pseudomembranous / Q000150:complications* / Q000401:mortality; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases; D011379:Prognosis; D013997:Time Factors