[Results of prenatal amniotic fluid diagnosis in suspected hemolytic disease of newborn].
759 amniotic fluid samples have been examined spectrophotometrically according to Liley and chemically for bilirubin from 286 patients with suspicion of morbus haemolyticus fetalis. The results obtained, gave the following findings for the procedure of Liley: sensitivity 75.0 per cent, specivity 96.5 per cent, accuracy 85.3 per cent, predictive value of positive test 95.6 per cent and predictive value of negative test 79.1 per cent and for the chemical test respectively: 88.2 per cent, 81.7 per cent, 85.0 per cent, 83.0 per cent and 87.2 per cent. A pathological delta E value is suspect of a serious erythroblastosis. But a serious morbus haemolyticus fetalis may be excluded with higher likelihood by concentration of bilirubin chemically determined below the pathological range then by correlated values of delta E. Finally we conclude that two different methods for amniotic fluid diagnostic are of higher predictability.
Stark
V K
VK
Klinik für Gynäkologie und Geburtshilfe, Wilhelm-Pieck-Universität Rostock.
Schwarzlos
G
G
During
R
R
Plesse
R
R
Hartwig
K
K
D000649:Amniocentesis; D000653:Amniotic Fluid / Q000032:analysis; D001663:Bilirubin / Q000032:analysis; D004899:Erythroblastosis, Fetal / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011379:Prognosis; D013053:Spectrophotometry
D001663:Bilirubin
Ergebnisse der pränatalen Fruchtwasserdiagnostik bei Verdacht auf Morbus haemolyticus fetalis.