Effects of peroral magnesium on plasma and skeletal muscle electrolytes in patients on long-term diuretic therapy.
Twenty patients on long-term diuretic therapy for arterial hypertension and/or congestive heart failure were given a supplementary dose of 15 mmol magnesium aspartate hydrochloride per day for 6 months. Nineteen patients, fulfilling the same admission criteria as the treatment group, served as controls. The addition of magnesium aspartate hydrochloride resulted in a significant rise of the cellular potassium and magnesium content and in a significant decrease of both systolic and diastolic blood pressure. It is concluded that supplementation with magnesium aspartate hydrochloride may effectively prevent the diuretic induced disturbances of electrolyte balance.
Dyckner
T
T
Department of Internal Medicine, University of Umeå, Sweden.
Wester
P O
PO
Widman
L
L
D000284:Administration, Oral; D000368:Aged; D004232:Diuretics / Q000009:adverse effects / Q000627:therapeutic use*; D004573:Electrolytes / Q000378:metabolism*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008274:Magnesium / Q000627:therapeutic use*; D008275:Magnesium Deficiency / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D011897:Random Allocation
D004232:Diuretics; D004573:Electrolytes; D008274:Magnesium