title: Drosophila Adh: a promoter element expands the tissue specificity of an enhancer.
abstract: Drosophila alcohol dehydrogenase (Adh) genes are expressed in the fat body and in species-specific sets of other tissues during larval and adult development. The Drosophila mulleri Adh-1 gene is expressed in the larval fat body and in three other larval tissues. In this paper, we show that Adh-1 expression in multiple cell types is the result of synergistic interactions between fat body-specific enhancers and a specific Adh-1 promoter element.
authors: Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
authors: J A
authors: JA
authors: Fischer
authors: T
authors: T
authors: Maniatis
mesh_terms: D000426:Alcohol Dehydrogenase / Q000032:analysis / Q000235:genetics*; D000818:Animals; D002872:Chromosome Deletion; D004330:Drosophila / Q000201:enzymology / Q000235:genetics*; D004742:Enhancer Elements, Genetic; D005216:Fat Body / Q000201:enzymology; D007814:Larva / Q000201:enzymology; D008317:Malpighian Tubules / Q000201:enzymology; D009154:Mutation; D009928:Organ Specificity; D011401:Promoter Regions, Genetic; D012045:Regulatory Sequences, Nucleic Acid; D013045:Species Specificity; D014158:Transcription, Genetic; D014170:Transformation, Genetic
chemical_list: D000426:Alcohol Dehydrogenase