Calcinosis cutis following extravasation of calcium chloride.
A 27-year-old woman with hypoparathyroidism developed multiple firm white-yellow papules along the path of an infiltrated calcium chloride intravenous infusion. A biopsy specimen obtained ten days after the extravasation revealed an urticarial reaction. A subsequent biopsy specimen, obtained 25 days after the extravasation, showed diffuse dermal calcification, confirmed by roentgenographic analysis, with incipient transepidermal elimination. A biopsy specimen obtained 40 days after the extravasation was consistent with an elimination reaction. An increase in mast cells was not noted. Electron microscopy showed mineral deposits along collagen fibrils without significant collagenous degeneration. In this report we describe a complication of intravenous calcium chloride infusion.
Goldminz
D
D
Department of Dermatology, Yale University School of Medicine, New Haven, Conn. 06510-8059.
Barnhill
R
R
McGuire
J
J
Stenn
K S
KS
D000328:Adult; D001706:Biopsy; D002114:Calcinosis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D002122:Calcium Chloride / Q000008:administration & dosage / Q000009:adverse effects*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000150:complications*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous / Q000009:adverse effects; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology
D002122:Calcium Chloride