title: [Occurrence of DNA structures which differ from the canonic B-form in sites of highly specific interaction with chromatin proteins].
abstract: According to the three-dimensional structure of DNase I and the mechanism of its action on linear double-stranded DNA, helix regions in conformations considerably different from the canonical B-form should be resistant to endonucleolysis. A number of DNA sequences specifically bound by nonhistone factors within 5'-flanking regions of the chicken beta A-globin, beta H-globin and c-myc genes are shown to contain short DNase I-resistant DNA domains. Several examples of the occurrence of such DNase I-resistant domains within the sites for high-specific recognition by different proteins are given. The role of the DNA structural polymorphism in site-specific interaction with protein factors is discussed.
authors: V V
authors: VV
authors: Lobanenkov
mesh_terms: D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D002645:Chickens; D002843:Chromatin / Q000378:metabolism*; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D003850:Deoxyribonuclease I / Q000378:metabolism; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation
chemical_list: D002843:Chromatin; D004247:DNA; D003850:Deoxyribonuclease I
vernacular_title: Vstrechaemost' struktur DNK, otlichnykh ot kanonicheskoĭ B-formy, v uchastkakh vysokospetsifichnogo vzaimodeĭstviia s belkami khromatina.