[Secretion of steroid hormones by the adrenals and ovaries and estradiol receptors in the uterine cytosol in postnatal ontogenesis].
The authors presented the results of a comparative study of ontogenesis of progesterone and estradiol production by the adrenal glands and ovaries in rats (from the 8th to the 60th days of life). A parallel study was made of the formation of the estradiol receptor system of the uterus. Immature rats adrenal glands in vitro were shown to produce much more progesterone than the ovaries. Progesterone production in the adrenal glands correlated with the intensity of corticosterone secretion. At the prepubertal age (the 8th-30th days of life) the adrenal glands and ovaries produced approximately the same amounts of estrogens determined as estradiol by a radioimmunoassay. The development of the uterine receptor system demonstrated parallelism with ontogenesis of the adrenal estrogen secreting activity. Such a regularity was undetectable for the ovaries. The authors discussed possible influence of the adrenal glands on the concentration of estradiol receptors in the uterus by means of estrogen synthesized by these receptors and immunologically similar to estradiol.
Tinnikov
A A
AA
Bazhan
N M
NM
Ivanova
L N
LN
D000311:Adrenal Glands / Q000378:metabolism*; D000375:Aging / Q000502:physiology*; D000818:Animals; D003345:Corticosterone / Q000378:metabolism; D003600:Cytosol / Q000502:physiology; D004967:Estrogens / Q000378:metabolism; D005260:Female; D010053:Ovary / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011959:Receptors, Estradiol / Q000502:physiology*; D011960:Receptors, Estrogen / Q000502:physiology*; D014599:Uterus / Q000502:physiology*
D004967:Estrogens; D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D011374:Progesterone; D003345:Corticosterone
Sekretsiia steroidnykh gormonov nadpochechnikami i iaichnikami i retseptsiia éstradiola v tsitozole matki v postnatal'nom ontogeneze.