[Metabolism of an antioxidant of the 3-hydroxypyridine class].
Study of biotransformation of 2-ethyl-6-methyl-3-hydroxypyridine (2E6M3O) in rats by using high performance liquid chromatography and mass spectrometry resulted in isolation and identification of its 5 metabolites represented by dealkylated and conjugated products of transformation. In terms of manifestation of the pharmacological effect of 2E3M3O, of interest may be the identified metabolite 2E6M3O-phosphate which was found in considerable amounts in the livers of the animals. All the rest metabolites were detected only in the rat urine.
Zherdev
V P
VP
Sariev
A K
AK
Voronina
T A
TA
Kliuev
N A
NA
Smirnov
L D
LD
D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000493:pharmacokinetics*; D001711:Biotransformation; D008099:Liver / Q000032:analysis / Q000378:metabolism; D008297:Male; D010847:Picolines / Q000032:analysis / Q000493:pharmacokinetics*; D051381:Rats; D013997:Time Factors
D000975:Antioxidants; D010847:Picolines; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Metabolizm antioksidanta iz klassa 3-oksipiridina.