Effect of 3-methylindole on respiratory ethane production in selenium and vitamin E deficient rats.
Lipid peroxidation has been proposed as a mechanism of 3-methylindole pneumotoxicity. In this report, lipid peroxidation was measured over 16 h in awake rats given 400 mg/kg i.p. 3-methylindole or its carrier, Cremophore EL. Rats were studied after 8 weeks of feeding a diet either adequate or deficient in vitamin E and selenium. Respiratory ethane production was used as the index of lipid peroxidation. 3-methylindole had no effect on lipid peroxidation for rats fed the adequate diet. For rats on the deficient diet, 3-methylindole suppressed lipid peroxidation by 50% of control. These results indicate that lipid peroxidation is not a mechanism of 3-methylindole pneumotoxicity and support the conclusion that 3-methylindole may act as an antioxidant.
Kiorpes
A L
AL
Department of Medical Sciences, School of Veterinary Medicine, College of Agriculture and Life Sciences, University of Wisconsin-Madison 53706.
Sword
J W
JW
Hoekstra
W G
WG
D000818:Animals; D004980:Ethane / Q000096:biosynthesis*; D007211:Indoles / Q000633:toxicity*; D008054:Lipid Peroxides / Q000378:metabolism*; D008171:Lung Diseases / Q000139:chemically induced*; D051381:Rats; D012119:Respiration; D012643:Selenium / Q000172:deficiency*; D012862:Skatole / Q000633:toxicity*; D014811:Vitamin E Deficiency / Q000378:metabolism*
D007211:Indoles; D008054:Lipid Peroxides; D012862:Skatole; D012643:Selenium; D004980:Ethane