[Nonuniform expression of the dopamine-positive effect in different central m-cholinergic blockaders].
In experiments on rats the degrees of the central m-cholinergic blocking (by the ability to suppress arecoline-induced tremor /AT/) and dopamine-potentiating (by potentiation of apomorphine-induced stereotypy (AS] effects of amizyl, glypine, scopolamine and 4-methylpyperidylbenzylate (4-MP) and an esther of phenylcyclopentylglycolinic acid and tropanol (PCT) were compared. It was found that with respect to AS and AT one can distinguish central m-cholinergic blocking agents with milddly (PCT, glypine) and strongly (4-MP, amizyl) dopamine-potentiating properties. None of these compounds administered in the doses corresponding to ED84 by AS influenced nicotine-induced tremor in rats.
Sprints
A M
AM
Vinogradov
V V
VV
Kolpinskaia
N D
ND
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001115:Arecoline / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects*; D004298:Dopamine / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D010276:Parasympatholytics / Q000494:pharmacology*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects; D014202:Tremor / Q000139:chemically induced / Q000517:prevention & control
D010276:Parasympatholytics; D001115:Arecoline; D001058:Apomorphine; D004298:Dopamine
O neravnomernoĭ vyrazhennosti dofaminopozitivnogo éffekta u razlichnykh tsentral'nykh m-kholinoblokatorov.