Antitumor and other effects of 24R,25-dihydroxycholecalciferol in Lewis lung carcinoma causing abnormal calcium metabolism in tumor-bearing mice.
Lewis lung carcinoma was found to cause hypercalcemia in tumor-bearing mice. 24R,25(OH)2D3 (K-DR, prepared by Kureha Chemical Ind.) significantly prolonged the survival time of mice with Lewis lung carcinoma. K-DR exhibited an antimetastatic effect on Lewis lung carcinoma, and also had an analgesic effect in mice with Lewis lung carcinoma.
Maeda
Y
Y
Biomedical Research Laboratories, Kureha Chemical Industry Co., Ltd., Tokyo, Japan.
Yamato
H
H
Hirai
T
T
Kobori
N
N
Fujii
T
T
Kobayashi
Y
Y
Saitoh
K
K
Inoguchi
E
E
Hakozaki
M
M
Iijima
H
H
D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism*; D002277:Carcinoma / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D004100:Dihydroxycholecalciferols / Q000494:pharmacology / Q000627:therapeutic use*; D006934:Hypercalcemia / Q000188:drug therapy / Q000209:etiology*; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D009362:Neoplasm Metastasis / Q000517:prevention & control
D000700:Analgesics; D000970:Antineoplastic Agents; D004100:Dihydroxycholecalciferols; C026032:25,26-dihydroxycholecalciferol; D002118:Calcium