Alcohol dehydrogenase is not a major determinant of alcohol preference in mice.
We present evidence that in MRL/Mp mice, difference in one gene affects the activity of alcohol dehydrogenase. MRL/Mp- + show high alcohol dehydrogenase (ADH) activity in the range of that found in C57BL/6, while MRL/Mp-lpr show ADH values in the range of non-drinker strains such as DBA/1, BALB/c, A, SJL, CBA and C3H/He. Voluntary alcohol consumption in MRL/Mp- + is 30-40% higher than that in the MRL/Mp-lpr. However, alcohol preference of both congenic strains is markedly lower than those of C57BL/6 mice. Our findings lead us to conclude that although alcohol dehydrogenase levels do relate to alcohol preference in mice, they are responsible for only a minor fraction of inter-strain differences.
Teichert-Kuliszewska
K
K
Department of Immunology, University of Toronto, Ontario, Canada.
Israel
Y
Y
Cinader
B
B
D000426:Alcohol Dehydrogenase / Q000235:genetics / Q000378:metabolism*; D000428:Alcohol Drinking / Q000502:physiology*; D000818:Animals; D005260:Female; D008099:Liver / Q000201:enzymology; D051379:Mice; D008815:Mice, Inbred Strains
D000426:Alcohol Dehydrogenase