title: Effect of low- and high-fat intakes on the hormonal milieu of premenopausal women.
abstract: To compare the influence of low- and high-fat diets on hormone metabolism, we studied six premenopausal women over two complete menstrual cycles. After an initial 7-10 d dietary adjustment subjects were randomly assigned to either low- (25% of calories) or high-fat (46% of calories) diets. The diets were isocaloric and similar in proportions of protein, polyunsaturated:saturated fatty acid ratio, fiber, and cholesterol. All subjects completed both diets in a crossover experimental design. Fasting blood and 24-h urine samples were collected every other day. No significant differences in plasma luteinizing hormone, progesterone, prolactin, estrone (E1), and estradiol-17 beta (E2) or in urinary E1, E2, and estriol were observed. Prolactin secretion in response to thyrotropin-releasing hormone stimulation was also unchanged. Dietary fat may influence breast-cancer incidence by modulating the hormonal environment; however, an increase in short-term fat intake from 28 to 51 g/1000 kcal did not lead to substantial differences in the hormonal milieu.
authors: Department of Nutrition, School of Public Health, Loma Linda University, CA 92350.
authors: M A
authors: MA
authors: Hagerty
authors: B J
authors: BJ
authors: Howie
authors: S
authors: S
authors: Tan
authors: T D
authors: TD
authors: Shultz
mesh_terms: D000328:Adult; D004041:Dietary Fats / Q000008:administration & dosage*; D002149:Energy Intake; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000652:urine; D004970:Estrone / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008593:Menopause; D008597:Menstrual Cycle; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood
chemical_list: D004041:Dietary Fats; D004967:Estrogens; D006728:Hormones; D004970:Estrone; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone