Transformation of polycythemia vera to acute nonlymphocytic leukemia accompanied by t(1;3)(p36;q21) karyotype.
The case of a patient with a history of polycythemia vera and 46,XX karyotype who transformed into acute nonlymphocytic leukemia with 46,XX,t(1;3)(p36;q21) rearrangement is reported. Significant percentages of the circulating blasts in the peripheral blood were positive on immunocytochemical stains for megakaryocyte markers, anti-Factor VIII, and antiglycoprotein IIb/IIIa. On the basis of our studies and published reports, trilineage hematopoietic abnormalities and a poor response to therapy may represent typical features of patients with t(1;3).
Najfeld
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Polly Annenberg Levee Hematology Center, Mount Sinai Medical Center, New York, NY 10029.
Coyle
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Berk
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D000208:Acute Disease; D002471:Cell Transformation, Neoplastic; D002878:Chromosomes, Human, Pair 1; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D011087:Polycythemia Vera / Q000150:complications / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic