[The search for preparations suppressing the reproduction of the AIDS virus].
Trials of clinically advantageous national inducers, thymus hormones, as well as human recombinant alpha 2-interferon were carried out in cultures of continuous lymphoblastoid cells H9/IIIB infected with HIV virus. The virus-inhibiting effect for HIV was observed with interferon in doses of 10-100 IU/ml. At a concentration of interferon of 1000 IU/ml, virus replication was inhibited completely, the interferon doses used exerting no marked toxic or antiproliferative effect on the cells. Human interferon inducers, poly(G).poly(C), PXL-6, dsRNA in concentrations of 50-100 micrograms/ml inhibited virus reproduction significantly. The highest antiviral effect was achieved with yeast dsRNA. The preparations of immunomodulators, thymarin, the 5th and 7th fractions of thymosin, noticeably stimulated proliferation of infected T-lymphocytes, reducing the relative number of cells carrying the virus-specific antigen. Combined use of preparations with different mechanisms of the antiviral effect may be advantageous in prevention and treatment of AIDS.
Nosik
D N
DN
Korneeva
M N
MN
Korsun
N S
NS
Maĭorova
S N
SN
Parshina
O V
OV
D000998:Antiviral Agents / Q000494:pharmacology*; D003864:Depression, Chemical; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D007369:Interferon Inducers / Q000494:pharmacology; D007370:Interferon Type I / Q000494:pharmacology; D009930:Organic Chemicals; D011066:Poly C / Q000494:pharmacology; D011068:Poly G / Q000494:pharmacology; D011994:Recombinant Proteins / Q000494:pharmacology; D013947:Thymosin / Q000031:analogs & derivatives / Q000494:pharmacology; D013951:Thymus Hormones / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D007369:Interferon Inducers; D007370:Interferon Type I; D009930:Organic Chemicals; D011994:Recombinant Proteins; D013951:Thymus Hormones; C033782:thymosin fraction 5; C055878:thymosin fraction 7; C055879:PXL 6; D011068:Poly G; C008961:poly G-poly C; D011066:Poly C; D013947:Thymosin; C017757:thymarin
Poisk preparatov, podavliaiushchikh reproduktsiiu virusa SPID.