Influence of soy protein or casein on pre-established atherosclerosis in rabbits.
Atherosclerosis was established in rabbits by feeding 1% cholesterol and 4% corn oil for two months. The rabbits were placed into five groups of equal average cholesterol level (2876 mg/dl) one of which was autopsied. The four remaining groups were placed on commercial ration (CR), CR plus 4% corn oil, or semipurified diets containing 14% coconut oil and 25% soy protein or casein. After two months, serum cholesterol levels in CR, CR plus corn oil, soy and casein groups had fallen by 91, 80, 81, and 64%, respectively. Aortic sudanophilia (%) in these four groups had increased by 106, 213, 238, and 25%, respectively. The findings confirm earlier observations that rabbit atherosclerosis does not regress when the atherogenic stimulus is removed.
Kritchevsky
D
D
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
Tepper
S A
SA
Weber
M M
MM
Klurfeld
D M
DM
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001161:Arteriosclerosis / Q000097:blood / Q000378:metabolism*; D002364:Caseins / Q000008:administration & dosage*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D004044:Dietary Proteins / Q000494:pharmacology*; D008297:Male; D014674:Plant Proteins, Dietary / Q000008:administration & dosage*; D011817:Rabbits; D030262:Soybean Proteins; D013025:Glycine max; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D002364:Caseins; D004044:Dietary Proteins; D014674:Plant Proteins, Dietary; D030262:Soybean Proteins; D014280:Triglycerides; D002784:Cholesterol