title: Light mitochondria and cellular thermogenesis.
abstract: We show that remarkable differences exist among 3 mitochondrial subpopulations with regard to oxidation-phosphorylation coupling. In the heavy fraction (sedimenting at 3,000 g) ATP synthesis is optimized while in the medium and light fractions (sedimenting at 10,000 and 27,000 g, respectively) heat production tends to be optimized as the mitochondrial size decreases. As the oxygen consumption of the L-fraction drastically increases (+150%) after fifteen days of cold exposure, such differences have remarkable implications for the mechanism of cellular thermogenesis and its regulation.
authors: Department of General and Environmental Physiology, University of Naples, Italy.
authors: F
authors: F
authors: Goglia
authors: G
authors: G
authors: Liverini
authors: A
authors: A
authors: Lanni
authors: S
authors: S
authors: Iossa
authors: A
authors: A
authors: Barletta
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D001833:Body Temperature Regulation; D003080:Cold Temperature; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000166:cytology / Q000502:physiology*; D010085:Oxidative Phosphorylation; D010101:Oxygen Consumption; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000255:Adenosine Triphosphate