Evidence for in situ amplification of a germ line homogeneously staining region in the mouse.
A cloned DNA sequence that is specific for a germ line homogeneously staining region (HSR) on chromosome 1 of the mouse was found to be homologous to a single copy sequence in non-HSR mice. By in situ hybridization, the sequence in non-HSR mice was localized to approximately the same site as the insertion site of the HSR on chromosome 1 of HSR mice, indicating in situ amplification of the HSR.
Boldyreff
B
B
Institut für Biologie, Medizinische Universität zu Lübeck, F.R. Germany.
Winking
H
H
Weith
A
A
Traut
W
W
D000818:Animals; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005784:Gene Amplification; D051379:Mice / Q000235:genetics*; D009693:Nucleic Acid Hybridization
D004247:DNA