[Hepatitis probably caused by Plethoryl. Apropos of 7 cases].
Seven patients developed acute hepatitis after receiving Plethoryl for obesity for 4 to 16 weeks. Jaundice was generally associated with or preceded by asthenia, nausea and pruritus. Serum aminotransferase activities were markedly increased whereas alkaline phosphatase and gamma-glutamyltransferase activities were moderately elevated. There was no hepatic failure. In all cases, Plethoryl administration was promptly discontinued. In 6 cases, jaundice disappeared within 2 to 4 weeks, and recovery occurred within 2 to 5 months. In one case, however, jaundice disappeared within 12 weeks and recovery took 10 months.
Larrey
D
D
Unité de Recherches de Physiopathologie Hépatique (INSERM U 24), Hôpital Beaujon, Clichy.
Fréneaux
E
E
Babany
G
G
Berson
A
A
Amédée-Manesme
O
O
Degott
C
C
Bettan
L
L
Paugam
B
B
Pessayre
D
D
Benhamou
J P
JP
D000208:Acute Disease; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003510:Cyclohexanes / Q000009:adverse effects*; D003512:Cyclohexanones / Q000009:adverse effects* / Q000378:metabolism; D004224:Diterpenes; D004338:Drug Combinations / Q000009:adverse effects / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008875:Middle Aged; D014284:Triiodothyronine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism; D014801:Vitamin A / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism
D003510:Cyclohexanes; D003512:Cyclohexanones; D004224:Diterpenes; D004338:Drug Combinations; D014284:Triiodothyronine; C044594:Plethoryl; D014801:Vitamin A
Hépatites probablement dues au Pléthoryl. A propos de 7 observations.