[The direct effect of pancreatic kallikrein (andecalin) on blood coagulation and fibrinolysis indices].
A direct effect of the preparation of pancreatic kallikrein on plasma hemostasis state was shown in experiments in vitro. Incubation of plasma with kallikrein led to an insignificant activation of contact factors of coagulation and suppression of the final stages of the clot formation at the level of the active thrombin formation and the fibrin-monomer polymerization. The growth of the anticoagulant and fibrinolytic activity was found. The possibility of studying the preparation as a thrombolytic agent in thrombotic situations is discussed.
Kiselev
V I
VI
Shakhmatov
I I
II
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D004285:Dogs; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D007610:Kallikreins / Q000494:pharmacology*; D008297:Male; D010184:Pancreatic Extracts / Q000494:pharmacology*; D010949:Plasma / Q000187:drug effects; D011205:Povidone / Q000494:pharmacology*; D012712:Serum Globulins / Q000502:physiology; D013917:Thrombin / Q000494:pharmacology; D014757:Viper Venoms / Q000494:pharmacology
D004338:Drug Combinations; D010184:Pancreatic Extracts; D012712:Serum Globulins; D014757:Viper Venoms; C019256:pancreatic extract, povidone drug combination; D007610:Kallikreins; D013917:Thrombin; D011205:Povidone
Priamoe vliianie pankreaticheskogo kallikreina (andekalina) na nekotorye pokazateli gemokoagiuliatsii i fibrinoliza.