Lack of effect of a single-dose of sulglicotide on the bioavailability of diclofenac.
The bioavailability of diclofenac (D) was assessed in 12 healthy volunteers treated orally with single doses of 100 mg (retard formulation) and subsequently retreated with the same dose of (D) plus sulglicotide (S) 200 mg. (D) blood levels were measured by GLC in samples collected after 1, 2, 4, 6, 8, 12, 24 h. No relevant difference was seen in (D) bioavailability after (S) administration; after 8 h plasma levels of (D) were slightly higher after (S) (p less than 0.05), but this difference can be considered incidental only. Thus, sulglicotide does not interfere with the bioavailability of diclofenac, and can be administered concurrently with the latter to prevent possible gastric injury by the antiinflammatory drug.
De Bernardi di Valserra
M
M
Istituto di Farmacologia Medica II, Università degli Studi di Pavia, Italy.
Feletti
F
F
Bertè
F
F
Nazzari
M
M
Cenedese
A
A
Cornelli
U
U
D000328:Adult; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001682:Biological Availability; D004008:Diclofenac / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D012795:Sialoglycoproteins / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D012795:Sialoglycoproteins; D004008:Diclofenac; C009354:sulglicotide