Retinoic acid increases the sensitivity of the rat embryo fibroblast transformation assay.
The rat embryo fibroblast focus assay is used to evaluate the transforming potential of several oncogenes. The sensitivity of this assay increased fivefold when retinoic acid was added to tissue culture media. Retinoic acid probably acts by selectively inhibiting the proliferation of nontransformed cells.
Halazonetis
T D
TD
Department of Genetics, Harvard Medical School, Boston, Massachusetts.
Daugherty
C
C
Leder
P
P
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004622:Embryo, Mammalian; D009857:Oncogenes; D010957:Plasmids; D051381:Rats; D014212:Tretinoin / Q000494:pharmacology*
D014212:Tretinoin