[Nature of the modifying action of polyunsaturated fatty acids on the growth of transplantable tumors of different types].
Modification effect of sodium salts and ethers of linolenic, arachidonic and alpha-linolenic acids on the growth of transplantable mouse tumors was examined. Polyunsaturated fatty acids (PUFA) enhanced the growth of mammary adenocarcinoma Ca-755, whereas the opposite effect was observed in mice with leukemia L-1210 and sarcoma 180. No differences in the growth of melanoma B-16 and Lewis lung carcinoma were noted in control and experimental animals. Modification effect of PUFA was significantly suppressed by prostaglandin inhibitor indomethacin and to a lesser extent by antioxidant alpha-tocopherol.
Kudriavtsev
I A
IA
Alekseev
S M
SM
Ashirova
V E
VE
Evstigneeva
R P
RP
Miasishcheva
N V
NV
D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D007939:Leukemia L1210 / Q000473:pathology; D008325:Mammary Neoplasms, Experimental / Q000473:pathology; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology*; D014810:Vitamin E / Q000494:pharmacology
D005231:Fatty Acids, Unsaturated; D014810:Vitamin E; D007213:Indomethacin
Kharakter modifitsiruiushchego deĭstvie polinenasyshchennykh zhirnykh kislot na rost perevivaemykh opukholeĭ raznogo tipa.