Low-dose cyclosporine A in severe psoriasis.
An open trial of 12 patients with severe long-standing psoriasis has shown CsA in small doses to be very effective in clearing the rash. Relapse occurred rapidly once treatment with the drug was stopped in this particular group of patients. Although adverse side effects did not occur in the short term, in 36 to 84 weeks the serum creatinine levels had risen in five of the seven patients. The implications of this are uncertain but seem likely to limit the drug's use on a long-term basis in treating psoriasis.
Marks
J
J
Department of Dermatology, University of Newcastle upon Tyne, UK.
D000293:Adolescent; D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*
D003524:Cyclosporins; D003404:Creatinine