Biodistribution of bis-[beta-(N,N,N-trimethylamino)ethyl]selenide-75Se diiodide, a potential articular cartilage imaging agent.
In an effort to develop a specific radiodiagnostic agent for articular cartilage imaging, we have investigated the biodistribution of bis[beta-(N,N,N-trimethylamino)ethyl]-selenide-75Se diiodide (75Se BISTAES) in rabbits. At an intravenous dose of 5 mg/kg, the greatest localization of the compound occurred in articular cartilage 15 min after injection. The compound was excreted rapidly in the urine. The results suggest that 75Se BISTAES has potential clinical use as an articular cartilage imaging agent.
Yu
W K
WK
School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana.
Bartlett
J M
JM
van Sickle
D C
DC
Mock
B H
BH
D000818:Animals; D002358:Cartilage, Articular / Q000000981:diagnostic imaging*; D011817:Rabbits; D011877:Radionuclide Imaging; D012644:Selenium Radioisotopes / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D012644:Selenium Radioisotopes; C055707:bis(N,N,N-trimethylamino)ethylselenide-Se iodide