Single-dose prophylaxis in gynaecological surgery: amoxycillin/clavulanic acid versus the combination of cefuroxim and metronidazole in a randomized prospective comparison.
A prospective randomized study was conducted comparing a single 2.2 g preoperative dose amoxycillin/clavulanic acid with a regimen of 1.5 g cefuroxim combined with 0.5 g metronidazole. Two hundred and fifty-one women were evaluated in this comparative study. The febrile morbidity, the incidence of urinary tract infections and the hospital stay were similar in both regimens. A single preoperative dose of amoxycillin/clavulanic acid was as effective as a combined regimen of cefuroxim and metronidazole and less expensive.
Friese
S
S
Department of Obstetrics and Gynaecology, Stichting Ignatius Ziekenhuis Breda, The Netherlands.
Pricker
G J
GJ
Willems
F T
FT
Loriaux
S M
SM
D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage*; D002444:Cefuroxime / Q000008:administration & dosage*; D002511:Cephalosporins / Q000008:administration & dosage*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014552:Urinary Tract Infections / Q000517:prevention & control
D002511:Cephalosporins; D002969:Clavulanic Acids; D008795:Metronidazole; D019818:Clavulanic Acid; D000658:Amoxicillin; D002444:Cefuroxime