title: Classical conditioning of rabbits 2-1/2 to 4 years old using mossy fiber stimulation as a CS.
abstract: A basic issue in age-related deterioration in memory formation concerns the locus of the age changes. Changes in peripheral portions of the auditory CS pathway could account for the observed age differences in classical conditioning in rabbits. We bypassed peripheral portions of the CS pathway and input the CS more centrally by electrical microstimulation of mossy fibers in the pons. New Zealand White rabbits aged 2-1/2-4 years were compared to six 3-month-old control rabbits with electrode implantations in comparable areas. Training consisted of 108 trials per day in which stimulation CS was paired with a corneal airpuff US. Older rabbits took almost five times as long to condition as the young animals. Thus, age differences in eyelid classical conditioning cannot be entirely attributed to changes in the peripheral CS pathway. Changes in the nervous system occurring more centrally in the cerebellum appear to affect learning and memory.
authors: Department of Psychology, Temple University, Philadelphia, PA 19122.
authors: D S
authors: DS
authors: Woodruff-Pak
authors: J E
authors: JE
authors: Steinmetz
authors: R F
authors: RF
authors: Thompson
mesh_terms: D000161:Acoustic Stimulation; D000375:Aging / Q000502:physiology*; D000818:Animals; D001306:Auditory Pathways; D001767:Blinking; D002531:Cerebellum / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology*; D004558:Electric Stimulation; D005260:Female; D008297:Male; D011149:Pons / Q000502:physiology; D011817:Rabbits