title: Testicular atrophy after oestrogen therapy.
abstract: Therapeutic use of oestrogens by males with carcinoma of the prostate leads to testicular atrophy with markedly reduced spermatogenesis after only 21 d (Oshima et al. 1974). Treatment for over a year results in paucity of germ cells, vacuolation of Sertoli cells and reduction in Leydig cells (Lu & Steinberger 1978, Smith & Urry 1985). There is, apparently, no information on the histology of the human testis after more than 1 year oestrogen therapy. We here report changes in testes from five transsexuals treated for periods of up to 5.5 years.
authors: Charing Cross & Westminster Medical School, London, UK.
authors: I D
authors: ID
authors: Venizelos
authors: F J
authors: FJ
authors: Paradinas
mesh_terms: D000328:Adult; D001284:Atrophy; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012708:Sertoli Cells / Q000187:drug effects / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors; D014189:Transsexualism
chemical_list: D004967:Estrogens