title: In vitro activation of the contact activation system (Hageman factor system) in plasma by acidic phospholipids and the inhibitory effect of beta 2-glycoprotein I on this activation.
abstract: 1. Negatively charged phospholipids promote initiation of the contact activation system in the blood coagulation. 2. Neutral phospholipids were unable to activate this system. 3. The activation is inhibited by beta 2-glycoprotein I at physiological concentrations. 4. The results raise the question whether people with low concentration of beta 2-glycoprotein I are more easily exposed to blood coagulation defects, such as disseminated intravascular coagulation, than those with normal concentration of beta 2-glycoprotein I.
authors: Department of Biochemistry C, Panum Institute, University of Copenhagen, Denmark.
authors: I
authors: I
authors: Schousboe
mesh_terms: D000838:Anions; D001777:Blood Coagulation / Q000187:drug effects*; D005174:Factor XII / Q000378:metabolism*; D005260:Female; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010713:Phosphatidylcholines / Q000494:pharmacology; D010714:Phosphatidylethanolamines / Q000494:pharmacology; D010718:Phosphatidylserines / Q000494:pharmacology; D010743:Phospholipids / Q000494:pharmacology*; D013696:Temperature; D053482:beta 2-Glycoprotein I
chemical_list: D000838:Anions; D006023:Glycoproteins; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010718:Phosphatidylserines; D010743:Phospholipids; D053482:beta 2-Glycoprotein I; D005174:Factor XII