Comparison of the pharmacokinetics and pharmacodynamics of torasemide and furosemide in healthy volunteers.
The pharmacodynamic effects and the pharmacokinetic parameters of torasemide (1-isopropyl-3- ([4-(3-methyl-phenylamino)pyridine]-3-sulfonyl)urea) 20 mg and furosemide 40 mg were compared after oral and intravenous administration in 6 healthy volunteers. The plasma elimination half-life for i.v. and oral torasemide was 2.2 h and 2.8 h, its bioavailability after oral administration was 91%, about 25% of the total body clearance was due to renal excretion both after iv. or oral application. For furosemide, a plasma elimination half-life of 0.6 h for i.v. and 0.8 h for oral application was found. The bioavailability was 40%, and about 62% of the drug was excreted via the kidney. Both drugs produced a similar diuretic and natriuretic effect. However, torasemide showed an increased duration of action compared to furosemide and a higher relation between urinary Na and K excretion, both after i.v. and oral administration, suggesting less loss of potassium after To. Both agents were well tolerated.
Lesne
M
M
Department of Pharmacology, Catholic University of Louvain, Brussels, Belgium.
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D004232:Diuretics / Q000493:pharmacokinetics* / Q000494:pharmacology; D004573:Electrolytes / Q000097:blood / Q000652:urine; D005665:Furosemide / Q000493:pharmacokinetics* / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D012016:Reference Values; D013449:Sulfonamides / Q000493:pharmacokinetics* / Q000494:pharmacology; D000077786:Torsemide
D004232:Diuretics; D004573:Electrolytes; D013449:Sulfonamides; D005665:Furosemide; D000077786:Torsemide