3-Mercaptopropionic acid administration into the caudate-putamen of the rat provokes dyskinesia.
The unilateral administration of 3-mercaptopropionic acid (MPA) through an implanted guide cannula into the caudate-putamen produced dyskinesia in the rat. Striatal GABA and dopamine were decreased and the dopamine metabolites 3,4-dihydroxyphenylacetic and homovanillic acid were increased on the MPA-injected side at 2-10 min after the onset of dyskinesia. The dyskinetic movements were blocked by GABA or alpha-aminooxaloacetic acid but not by glycine or haloperidol.
Toth
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Nathan S. Kline Institute for Psychiatric Research, Center for Neurochemistry, New York, NY 10035.
Lajtha
A
A
D015097:3-Mercaptopropionic Acid / Q000633:toxicity*; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000378:metabolism; D011699:Putamen / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013438:Sulfhydryl Compounds; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D013438:Sulfhydryl Compounds; D005680:gamma-Aminobutyric Acid; D015097:3-Mercaptopropionic Acid