title: Anticoccidial activity of combinations of narasin and nicarbazin.
abstract: The efficacy of mixtures of narasin and nicarbazin were evaluated by comparing broiler performance, susceptibility to heat stress, and the mode of action against Eimeria. In a floor pen trial, narasin (70 ppm) alone or in combination with nicarbazin at levels between 10/10 and 50/50 ppm gave significantly better performance than unmedicated birds or birds given nicarbazin at 125 ppm alone. Amelioration of nicarbazin-associated mortality with heat as a stressor was observed in birds given the 50/50 ppm mixture of narasin and nicarbazin: mortality in these birds was similar to that of unmedicated birds and was reduced by 15 to 20% of that occurring in birds in the nicarbazin (125 ppm) treatment. The narasin/nicarbazin mixture (50/50) appears primarily to prevent further development of sporozoites. However, in birds treated with 25/25 ppm of narasin and nicarbazin, both the deleterious action of nicarbazin on merogeny and the antisporozoite activity of narasin were observed.
authors: Department of Poultry Science, University of Georgia, Athens 30602.
authors: P L
authors: PL
authors: Long
authors: J
authors: J
authors: Johnson
authors: M E
authors: ME
authors: McKenzie
mesh_terms: D000818:Animals; D002224:Carbanilides / Q000627:therapeutic use*; D002645:Chickens / Q000469:parasitology*; D003048:Coccidiosis / Q000517:prevention & control / Q000662:veterinary*; D003049:Coccidiostats / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006358:Hot Temperature / Q000009:adverse effects; D006813:Humidity / Q000009:adverse effects; D008297:Male; D009528:Nicarbazin / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000469:parasitology / Q000517:prevention & control*; D011714:Pyrans / Q000627:therapeutic use*; D013312:Stress, Physiological / Q000209:etiology / Q000662:veterinary
chemical_list: D002224:Carbanilides; D003049:Coccidiostats; D004338:Drug Combinations; D011714:Pyrans; D009528:Nicarbazin; C013612:narasin