title: Platelet associated IgG, platelet mean life span and treatment with intravenous immunoglobulin in idiopathic thrombocytopenic purpura.
abstract: The clinical significance of platelet associated IgG in ITP detected by direct platelet suspension immunofluorescence test (PSIFT) was studied. The platelet mean life span (MLS) was measured with 111In-labelled platelets in 17 adult patients. All the patients had shortened platelet MLS. The direct PSIFT was positive in 14 patients. Patients were initially treated with prednisone; 12 patients with poor response to the drug were splenectomised. 8 of these 12 patients were treated with intravenous immunoglobulin (IvIg) before splenectomy. The response to IvIg was as good or better in the 3 patients with negative PSIFT, than in the 5 patients with positive PSIFT.
authors: Finnish Red Cross Blood Transfusion Service, Helsinki, Finland.
authors: U
authors: U
authors: Nieminen
authors: M
authors: M
authors: Syrjälä
authors: E
authors: E
authors: Ikkala
authors: G
authors: G
authors: Myllylä
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000276:immunology*; D002470:Cell Survival; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011696:Purpura, Thrombocytopenic / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G