title: Effects of progesterone on thermosensitive neurons in preoptic slice preparations.
abstract: Single neuronal activities in preoptic (PO) slice preparations from both male and female rats were recorded and examined for their responses to 3 ng/ml or 30 ng/ml progesterone (P). Of 31 warm-sensitive neurons, 19 (61.3%) were inhibited by P, 5 (16.1%) were excited, and 7 (22.6%) did not respond to P. Of 26 thermally insensitive neurons, 4 (15.4%) were inhibited by P, 3 (11.5%) were excited, and 19 (73.1%) did not respond to P. Of 4 cold-sensitive neurons, 3 were inhibited and one was excited. These results demonstrate that P inhibits most warm-sensitive neurons directly or indirectly via local neuronal circuits in the slice.
authors: Department of Physiology, Osaka University Medical School, Japan.
authors: C L
authors: CL
authors: Tsai
authors: K
authors: K
authors: Matsumura
authors: T
authors: T
authors: Nakayama
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003080:Cold Temperature; D005260:Female; D006358:Hot Temperature; D066298:In Vitro Techniques; D008297:Male; D011301:Preoptic Area / Q000187:drug effects / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D013823:Thermoreceptors / Q000187:drug effects / Q000502:physiology*
chemical_list: D011374:Progesterone