A calcium-activated, nonselective cationic conductance in Aplysia silent neurons.
We have previously reported the activation of a triphasic current response by calcium injection in voltage-clamped, nonbursting neurons of Aplysia californica. Present evidence indicates that the second phase, a delayed inward current that peaks 10-20 seconds after the end of the injection, is a calcium-activated, nonselective cationic conductance. It can be carried by both sodium and calcium, is not sensitive to chloride concentration changes, but is voltage sensitive, decreasing in amplitude with hyperpolarization.
Jones
L S
LS
Department of Pediatrics (Neurology), Duke University Medical Center, Durham, NC 27710.
Lewis
D V
DV
D000818:Animals; D001048:Aplysia / Q000502:physiology*; D002118:Calcium / Q000494:pharmacology / Q000502:physiology*; D002412:Cations / Q000502:physiology; D002712:Chlorides; D005724:Ganglia / Q000187:drug effects / Q000502:physiology*; D008345:Manganese / Q000494:pharmacology; D017895:Manganese Compounds; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology
D002412:Cations; D002712:Chlorides; D017895:Manganese Compounds; D008345:Manganese; C025340:manganese chloride; D002118:Calcium