Total, tartrate-resistant, and tartrate-inhibited acid phosphatases in serum: biological variations and reference limits.
We studied several factors affecting biological variation in serum acid phosphatases in a population of 1195 apparently healthy subjects four years old or older. We assayed total acid phosphatase activities in the presence of a transphosphorylating agent and using alpha-naphthyl phosphate as substrate. The main factors modifying total and tartrate-resistant acid phosphatases activities in serum are similar to those observed for total and bone alkaline phosphatases activities: age, sex, and hormonal state (puberty or menopause). The tartrate-inhibited acid phosphatase activity is, however, independent of biological variations. Finally, we propose reference limits for total, tartrate-resistant, and tartrate-inhibited acid phosphatases in serum.
Schiele
F
F
Centre de Médecine Préventive, Vandoeuvre-lès-Nancy, France.
Artur
Y
Y
Floc'h
A Y
AY
Siest
G
G
D000135:Acid Phosphatase / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008572:Menarche; D008593:Menopause; D008875:Middle Aged; D012015:Reference Standards; D012737:Sex Factors; D013644:Tartrates / Q000494:pharmacology*
D013644:Tartrates; D000135:Acid Phosphatase; C029768:tartaric acid