Uptake of 19 hydrocarbon vapors inhaled by F344 rats.
The comparative rates of uptake of 19 hydrocarbon vapors by rats were determined by a dual-column gas chromatograph method. The hydrocarbons ranged in volatility from propylene (BP -47.7 degrees C) to 1,2,4-trimethylbenzene (BP 169 degrees C). Representative compounds from the chemical classes of alkenes, alkynes, straight-chain and branched alkanes, alicyclics, and aromatics were examined. Trends observed included: (1) highly volatile hydrocarbons were less well-absorbed than less volatile hydrocarbons; (2) unsaturated compounds were better absorbed than saturated ones; and (3) branched hydrocarbons were less well-absorbed than unbranched ones. The data indicate that uptake rates among inhaled hydrocarbon vapors may be predicted from the molecular structures and physical properties of the hydrocarbons.
Dahl
A R
AR
Lovelace Biological and Environmental Research Institute, Albuquerque, New Mexico 87185.
Damon
E G
EG
Mauderly
J L
JL
Rothenberg
S J
SJ
Seiler
F A
FA
McClellan
R O
RO
D000280:Administration, Inhalation; D000818:Animals; D002849:Chromatography, Gas; D006838:Hydrocarbons / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013329:Structure-Activity Relationship
D006838:Hydrocarbons