Effects of oral prazosin on total plasma digoxin levels.
Prazosin and digoxin are frequently coadministered in clinical practice. To determine the effects of oral prazosin treatment on steady-state digoxin levels, 20 patients receiving a constant maintenance dose of digoxin, who had normal renal and liver functions and were not receiving any other treatment, were given 5 mg of prazosin for 3 days. Plasma digoxin levels were measured before, on days 1 and 3 of prazosin treatment, and after prazosin had been discontinued. It was found that prazosin significantly increased plasma digoxin levels. On discontinuation of prazosin digoxin levels returned to their previous values.
Copur
S
S
Department of Cardiology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
Tokgözoğlu
L
L
Oto
A
A
Oram
E
E
Uğurlu
S
S
D000284:Administration, Oral; D000328:Adult; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000008:administration & dosage / Q000494:pharmacology*
D004077:Digoxin; D011224:Prazosin