The effect of amino acid infusion on partial pressure of oxygen in pelvic urine of the rat.
Renal function decreases with age, but the precise mechanism of the decrease is unknown. Recently, Brenner et al. have proposed the hypothesis that high protein intake may injury renal function in various clinical settings including the aging kidney. Since connective tissue in the renal papilla changes with age, high protein intake may have some deleterious effect on the renal papilla. In this study, the effect of amino acid infusion on partial pressure of oxygen of pelvic urine was examined in the rat. After amino acid infusion, glomerular filtration rate significantly increased and partial pressure of oxygen of pelvic urine decreased, while partial pressure of oxygen of arterial blood remained unchanged. The findings imply that high protein intake may affect the renal papilla both acutely and chronically through renal medullary hypoxia.
Inoue
G
G
Department of Medicine, Tokyo Metropolitan Tama Geriatric Hospital, Japan.
Toba
K
K
D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005919:Glomerular Filtration Rate; D007262:Infusions, Intravenous; D008297:Male; D010100:Oxygen / Q000097:blood / Q000652:urine*; D010313:Partial Pressure; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine
D000596:Amino Acids; D012964:Sodium; D010100:Oxygen