[Bismuth subsalicylate treatment in chronic Campylobacter pylori-associated erosive gastritis].
In a prospective open study 21 patients with upper abdominal complaints and chronic active gastritis as well as endoscopically proven erosions were treated with bismuth subsalicylate (4 X 30 ml/day, corresponding to 4 X 314 mg Bi3+) for three weeks. In 20 patients (95%) Campylobacter pylori (CP) was found in at least two of three examinations (culture, CLO quick-test, special histology). After the treatment 17 of 21 patients (81%) were CP negative, and the clinical symptoms had gradually disappeared. The histologically demonstrated degree of activity had regressed significantly after the three-week treatment; in 90% of patients the inflammatory process had completely abated. These results demonstrate that bismuth subsalicylate is highly effective in the acute treatment of CP-associated chronic erosive gastritis.
Malfertheiner
P
P
Abteilung Innere Medizin II, Universitätsklinikum Ulm.
Stanescu
A
A
Baczako
K
K
Vanek
E
E
Bode
G
G
Ditschuneit
H
H
D000328:Adult; D000368:Aged; D001706:Biopsy; D001729:Bismuth / Q000097:blood / Q000627:therapeutic use*; D002167:Campylobacter / Q000302:isolation & purification; D002169:Campylobacter Infections / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D009942:Organometallic Compounds / Q000097:blood / Q000627:therapeutic use*; D012459:Salicylates / Q000097:blood / Q000627:therapeutic use*
D009942:Organometallic Compounds; D012459:Salicylates; C015715:bismuth subsalicylate; D001729:Bismuth
Wismutsubsalicylat-Behandlung bei Campylobacter-pylori-assoziierter chronischer erosiver Gastritis.