Synthesis of hexanucleotide analogues containing diisopropylsilyl internucleotide linkages.
The synthesis of two silyl-linked hexanucleotide analogues is described. Hypochromicity and CD measurements indicate that the thymidine hexanucleotide analogue bears a strong resemblance to its phosphodiester-linked counterpart.
Cormier
J F
JF
Department of Chemistry, McGill University, Montreal, Quebec, Canada.
Ogilvie
K K
KK
D002942:Circular Dichroism; D007202:Indicators and Reagents; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis*; D012821:Silanes; D012825:Silicon; D013329:Structure-Activity Relationship; D013936:Thymidine
D007202:Indicators and Reagents; D009841:Oligonucleotides; D012821:Silanes; D013936:Thymidine; D012825:Silicon