title: Resistance of the peripheral nerve to ischemia in diabetic patients--an electrophysiological study.
abstract: We studied the effect of ischemia on the excitability of the sensory fibers of the median nerve in 43 patients with non-insulin-dependent diabetes mellitus (NIDDM) by a double stimulation method. Ischemia caused significantly less reduction of nerve excitability in patients with poor glycemic control and in patients diseased for 5 years or longer than in the normal control group. Hyperexcitability after ischemia was markedly greater than normal among short-term, poorly controlled diabetics, and markedly less pronounced among long-term, poorly controlled diabetics. In many diabetic patients with normal conduction velocity or without sensory disturbance, post-ischemic hyperexcitability was remarkable. A study of nerve excitability may be useful as one means of detecting early-stage disturbance of the diabetic peripheral nerve.
authors: Second Department of Internal Medicine, Osaka University Medical School, Japan.
authors: M
authors: M
authors: Takahashi
authors: S
authors: S
authors: Nozaki
authors: Y
authors: Y
authors: Nakamura
authors: H
authors: H
authors: Imaoka
authors: N
authors: N
authors: Kono
authors: S
authors: S
authors: Tarui
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology; D005260:Female; D006801:Humans; D007511:Ischemia / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000098:blood supply* / Q000503:physiopathology