[Features of blood coagulating and fibrinolytic properties under the action of epinephrine in hypoxia and hypercapnia].
Acute experiments were carried out on 50 dogs to study the effect of epinephrine in hypoxic (N2 - 15 to 10% O2) or hypoxic-hypercapnic (N2 - 10%, O2 - 5% CO2) atmospheres. Epinephrine led to a maximum increase of blood coagulation and fibrinolysis in normoxic atmosphere. Hypoxia reduced the shift of most hemostasis parameters in response to epinephrine. However, in N2 - 10% O2 atmosphere the epinephrine-induced increase of blood coagulation was superimposed on initial hypoxic hypercoagulation and caused serious disorders in hemostasis. In hypoxic-hypercapnic atmosphere increase of blood coagulation in response to epinephrine was more than doubled when compared to that in hypoxic atmosphere, reaching control values. Nevertheless, after epinephrine administration the ratio of coagulatory, anticoagulatory and fibrinolytic activities was more beneficial in hypoxia-hypercapnia and the coagulation potential was lower than in hypoxic or normoxic atmospheres.
Pak
G D
GD
Sverchkov
V S
VS
Danilevskaia
T N
TN
Trandafilova
T P
TP
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects*; D006935:Hypercapnia / Q000097:blood*; D000860:Hypoxia / Q000097:blood*
D004837:Epinephrine
Osobennosti svertyvaiushchikh i fibrinoliticheskikh svoĭstv krovi pri deĭstvii adrenalina v usloviiakh gipoksii i giperkapnii.