[35S]TBPS binding to membranes of the female sex organs: modulation of chloride ionophore by GABA and pentobarbital.
The capacity of membranes from the ovaries, oviducts and uteri of rats to bind [35S]t-butylbicyclo-phosphorothionate (TBPS), and the effect of gamma-aminobutyric acid (GABA) and pentobarbital on the specific binding of TBPS were examined. Specific TBPS binding, that could be modulated by GABA and pentobarbital in an allosteric manner, was demonstrated. These findings indicate that the TBPS-labeled chloride ion channels in the female sex organs are regulated by GABA and pentobarbital sites, in a fashion similar to that observed in the brain.
Erdö
S L
SL
Pharmacological Research Centre, Chemical Works of Gedeon Richter Ltd., Budapest, Hungary.
Maksay
G
G
D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000378:metabolism*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism; D003292:Convulsants / Q000378:metabolism*; D005187:Fallopian Tubes / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism*; D066298:In Vitro Techniques; D007476:Ionophores / Q000494:pharmacology*; D008566:Membranes / Q000378:metabolism; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000187:drug effects / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; D002712:Chlorides; D003292:Convulsants; D007476:Ionophores; D005680:gamma-Aminobutyric Acid; C037476:tert-butylbicyclophosphorothionate; D010424:Pentobarbital