Transplantation of neural tissue in polymer capsules.
Neural tissue reaction to permselective polymer capsules and the feasibility of encapsulated neural tissue transplantation were evaluated in a rat model for a period of 1-12 weeks. Polymer implants in the central nervous system were generally well tolerated. The brain reaction to the synthetic material was minimal and did not disturb normal brain architectonics. Embryonic mouse mesencephalon enclosed in a polymer capsule remained morphologically intact for at least 12 weeks in the parietal cortex of rats. We conclude that the immunoprotection provided by a permselective polymer membrane encapsulating neural tissue is compatible with diffusional exchange of nutrients and metabolites. Polymer encapsulation may provide an alternative for the problem of immunorejection in transplantation of neural tissues.
Aebischer
P
P
Artificial Organ Laboratory, Brown University, Providence, RI 02912.
Winn
S R
SR
Galletti
P M
PM
D000818:Animals; D002214:Capsules; D006085:Graft Survival; D008297:Male; D008636:Mesencephalon / Q000637:transplantation* / Q000648:ultrastructure; D051379:Mice; D008854:Microscopy, Electron; D010296:Parietal Lobe / Q000502:physiology* / Q000648:ultrastructure; D011143:Polyvinyl Chloride; D011145:Polyvinyls; D051381:Rats; D011919:Rats, Inbred Strains; D014181:Transplantation Immunology; D014183:Transplantation, Heterologous / Q000379:methods*
D002214:Capsules; D011145:Polyvinyls; D011143:Polyvinyl Chloride