title: Post-hypoxic action (intention) myoclonus: a clinico-electroencephalographic study.
abstract: A patient with post-hypoxic action myoclonus classified as reticular reflex myoclonus was subjected to an electrophysiological investigation. The myoclonic movements involved mainly the legs but could also affect the whole body. Somatosensory evoked responses were not increased and electroencephalography (EEG) was normal when the patient was relaxed. Startle, self-paced movement or movement on command induced repetitive myoclonic jerks preceded and accompanied by repetitive small spikes in the EEG with phase reversal in the midline at the vertex or slightly posterior to it, regardless of the limb moved. The central spiking subsided considerably earlier than the myoclonic jerks as shown by polygraphic recordings. The EEG spikes were also provoked by mere imagination of movement and persisted in spite of a dramatic reduction of myoclonic activity after treatment with clonazepam. The observations suggest that the vertex spiking in post-hypoxic action myoclonus indicates synchronous cortical activation, but is not closely coupled with activation of the Betz cells of layer V where the pyramidal pathway originates.
authors: Neurologische Klinik, Medizinische Einrichtungen der Universität, Düsseldorf, Federal Republic Germany.
authors: O W
authors: OW
authors: Witte
authors: E
authors: E
authors: Niedermeyer
authors: G
authors: G
authors: Arendt
authors: H J
authors: HJ
authors: Freund
mesh_terms: D001012:Aorta, Abdominal / Q000601:surgery; D001157:Arterial Occlusive Diseases / Q000601:surgery; D002998:Clonazepam / Q000627:therapeutic use; D004569:Electroencephalography; D006801:Humans; D007083:Iliac Artery / Q000601:surgery; D007866:Leg / Q000294:innervation; D008297:Male; D008875:Middle Aged; D009068:Movement; D009207:Myoclonus / Q000188:drug therapy / Q000503:physiopathology*; D014656:Vascular Surgical Procedures / Q000009:adverse effects
chemical_list: D002998:Clonazepam