[Sequential animal experimental determination of optimal dosages for combinations of cytostatics using a reduced number of experimental animals (vepeside/ifosfamide combination)].
Complete groups of animals can be economized by application of the Box-Wilson-method to experimental determination of an optimal dosage for a drug combination. It is possible to minimize the number of controls additionally by means of successive cumulation of the number of controls additionally by means of successive cumulation of control-dates of interest over the single experiments of the series required and to improve the estimation of the reference parameter. An example is given to explain the procedure of evaluation of an optimal dosage for the two-drug combination VP16/IFX. Side effects are taken into consideration. An advantage is proved for the combination against the single substances.
Steinhoff
G
G
Zentralinstitut für Krebsforschung, Akademie der Wissenschaften der DDR, Robert-Rössle-Institut, Berlin-Buch.
Nowak
C
C
Arnold
W
W
Tanneberger
S
S
D000818:Animals; D000830:Animals, Laboratory; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use; D005047:Etoposide / Q000008:administration & dosage; D007069:Ifosfamide / Q000008:administration & dosage; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D012107:Research Design
D005047:Etoposide; D007069:Ifosfamide
Sequentielle tierexperimentelle Bestimmung optimaler Dosierungen für Zytostatika-Kombinationen mit reduzierter Anzahl von Versuchstieren (Kombination Vepesid/Ifosfamid).