title: Activation of protein kinase C by fatty acids and its dependency on Ca2+ and phospholipid.
abstract: Ca2+- and phospholipid-dependent protein kinase (PKC) was activated by arachidonic and myristic acids. This activation by both fatty acids required the calcium ion. Acidic phospholipid was also required for the activation by myristic acid, while that by arachidonic acid was inhibited by phospholipid.
authors: Department of Medical Biology, Kochi Medical School, Japan.
authors: Y M
authors: YM
authors: Morimoto
authors: K
authors: K
authors: Nobori
authors: K
authors: K
authors: Edashige
authors: M
authors: M
authors: Yamamoto
authors: S
authors: S
authors: Kobayashi
authors: K
authors: K
authors: Utsumi
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D001921:Brain / Q000201:enzymology*; D002118:Calcium / Q000032:analysis / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D005227:Fatty Acids / Q000494:pharmacology*; D008297:Male; D009227:Myristic Acids / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism / Q000494:pharmacology*; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001095:Arachidonic Acids; D005227:Fatty Acids; D009227:Myristic Acids; D010743:Phospholipids; D011493:Protein Kinase C; D002118:Calcium