Effects of bromocriptine and ectopic pituitary transplants on pituitary and hypothalamic nuclear androgen receptors in the male hamster.
Nuclear androgen receptors (ARN) were measured in the pituitaries and hypothalami of adult male golden hamsters which had been injected with a long-acting preparation of bromocriptine or had pituitaries from adult females transplanted under the renal capsules. Treatment with bromocriptine markedly reduced pituitary ARN and plasma prolactin levels without altering plasma testosterone levels or hypothalamic ARN. Ectopic pituitary transplants did not affect ARN in either the pituitary or the hypothalamus. These findings suggest that normal rates of prolactin synthesis and/or secretion may be required for maintenance of ARN in the pituitary of adult male hamsters.
Prins
G S
GS
Department of Obstetrics and Gynecology, Michael Reese Medical Center, Pritzker School of Medicine, University of Chicago, Ill.
Bartke
A
A
Chandrashekar
V
V
Reiher
J
J
Hodges
S
S
Meyers
R
R
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D006224:Cricetinae; D005260:Female; D007031:Hypothalamus / Q000032:analysis*; D008297:Male; D008647:Mesocricetus; D010902:Pituitary Gland / Q000032:analysis* / Q000637:transplantation; D011388:Prolactin / Q000097:blood*; D011944:Receptors, Androgen / Q000032:analysis*
D011944:Receptors, Androgen; D001971:Bromocriptine; D011388:Prolactin