Conditions for optic axon outgrowth.
A series of studies is described which show that retinal axon outgrowth can be stimulated by the close proximity of an appropriate target region. The suggestion is offered that, in normal development, optic axons first follow cues available at the surface of the brainstem, but once they reach a target region, ramify there in response to the presence of a target-derived factor.
Lund
R D
RD
Department of Neurobiology, Anatomy and Cell Science, University of Pittsburgh School of Medicine, Pa.
Hankin
M H
MH
Sefton
A J
AJ
Perry
V H
VH
D000818:Animals; D001369:Axons / Q000502:physiology*; D002470:Cell Survival; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000196:embryology* / Q000637:transplantation; D012165:Retinal Ganglion Cells / Q000502:physiology