Analgesics and warfarin. A case that brings up questions and cautions.
This case report describes prolongation of a patient's prothrombin time and partial thromboplastin time possibly due to coadministration of warfarin and an overdose of an acetaminophen-propoxyphene combination analgesic. Patients receive warfarin for many indications, and concomitant use of an analgesic agent is commonly required. These patients should be closely observed if a combination acetaminophen-propoxyphene product is prescribed. Finally, patients receiving warfarin should be warned about the risks of use (and overdose) of unprescribed medications.
Justice
J L
JL
Department of Pharmacy, School of Allied Health, Medical College of Ohio at Toledo.
Kline
S S
SS
D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects*; D001777:Blood Coagulation / Q000187:drug effects*; D011431:Dextropropoxyphene / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations / Q000008:administration & dosage / Q000009:adverse effects; D004347:Drug Interactions; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D012651:Self Medication; D014859:Warfarin / Q000009:adverse effects* / Q000627:therapeutic use
D000700:Analgesics; D004338:Drug Combinations; D000082:Acetaminophen; C011800:acetaminophen, dextropropoxyphene, drug combination; D014859:Warfarin; D011431:Dextropropoxyphene