[Genetic aspects of the immunomodulating action of interferon].
The data of the study of alpha/beta interferon (IFN) effect in mice of different genotype were presented. CBA mice of H-2k genotype, C57B1/6 mice of H-2b genotype and their hybrid (CBA X C57B1/6) F1 have been used in the experiments. IFN has been injected intraperitoneally in a dose of 100-5000 U/mouse in combination with antigenic stimulation. It was shown that IFN enhanced stem cells migration from bone marrow in CBA, but not in (CBA X C57B1/6)F1 mice. At the same time the splenocytes from CBA mice were more sensitive to inhibition by IFN than splenocytes from C57B1/6 mice. This was found in antibody and immune rosette-formation tests. The effect of IFN on the immune system cells is probably predetermined by the individual genetic characteristics of a mouse strain.
Sorokin
A M
AM
Chermeneva
L M
LM
Shchurina
G V
GV
D000276:Adjuvants, Immunologic / Q000235:genetics* / Q000276:immunology; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006824:Hybridization, Genetic; D007370:Interferon Type I / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D008808:Mice, Inbred CBA / Q000235:genetics; D012397:Rosette Formation
D000276:Adjuvants, Immunologic; D007370:Interferon Type I
Geneticheskie aspekty immunomoduliruiushchego deĭstviia interferona.