Influence of proximal colostomy on the healing of a left colon anastomosis: an experimental study in the rat.
The healing of an experimental left colon anastomosis protected by a proximal diverting colostomy was studied in the rat. Collagen synthesis in the anastomotic area was measured by incorporation of [3H]proline. With a defunctioning proximal colostomy, the synthesis and accumulation of collagen in the anastomosis was diminished, and the anastomotic strength development delayed and reduced. The development of anastomotic strength seems to proceed according to the level of strain from intraluminal bulk. As the healing of the anastomosis protected by a diverting colostomy was uncomplicated, these findings should not contra-indicate the use of diverting colostomy.
Udén
P
P
Department of Surgery, Lund University, Malmö, Sweden.
Blomquist
P
P
Jiborn
H
H
Zederfeldt
B
B
D000714:Anastomosis, Surgical; D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D003106:Colon / Q000378:metabolism / Q000601:surgery*; D003125:Colostomy; D008297:Male; D011184:Postoperative Period; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing
D003094:Collagen