[Pharmacokinetics of anthracycline antibiotics deposited by polymers].
An increase of doxorubicin concentration in different organs and tissues and its decrease in the peripheral blood were observed when studying pharmacokinetics of this drug administered in the 10% solution of polyvinylpyrrolidone. A prolonged and stable release of carminomycin from glue composition MK-10-0 "carminacryl" confirms an expediency of alpha-cyanoacrylate use for deposition of anthracycline antibiotics with the aim of loco-regional chemotherapy.
Rusakov
I G
IG
Li
A D
AD
Akimova
A Ia
AIa
Shchitkov
K G
KG
D000818:Animals; D002360:Carubicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003487:Cyanoacrylates / Q000008:administration & dosage*; D003630:Daunorubicin / Q000031:analogs & derivatives*; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004353:Drug Evaluation, Preclinical; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D014677:Pharmaceutical Vehicles; D011205:Povidone / Q000008:administration & dosage*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D003487:Cyanoacrylates; D014677:Pharmaceutical Vehicles; D004317:Doxorubicin; D002360:Carubicin; D011205:Povidone; D003630:Daunorubicin
Izuchenie farmakokinetiki antratsiklinovykh antibiotikov deponirovannykh polimerami.