[Use of nitrosourea derivatives in the treatment of patients with Hodgkin's disease with lesions of the central nervous system].
The study deals with the effectiveness of nitrosourea derivatives (nitrosomethylurea and CCNU) used for monochemotherapy or polychemotherapy in combination with vinca alkaloids, natulan and prednisolone in 22 patients suffering Hodgkin's disease with spinal cord and intracranial involvement. Complete regression of neurologic symptoms was seen in 61.1% of patients with spinal cord dysfunction and in 3 of 4 cases of brain involvement. The effectiveness of nitrosomethylurea-based regimens did not differ-significantly from those including CCNU. The longest complete remission obtained was 124+ months. No relationship was found between the type, degree and duration of symptoms, on the one hand, and the likelihood of achieving complete remission, on the other.
Gershanovich
M L
ML
Arkhipov
A I
AI
Vilenskiĭ
B S
BS
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy*; D004341:Drug Evaluation; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage / Q000627:therapeutic use*; D008770:Methylnitrosourea / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D013120:Spinal Cord Neoplasms / Q000188:drug therapy*; D014748:Vinca Alkaloids / Q000008:administration & dosage
D014748:Vinca Alkaloids; D011344:Procarbazine; D008770:Methylnitrosourea; D008130:Lomustine; D011239:Prednisolone
Primenenie proizvodnykh nitrozomocheviny v lechenii bol'nykh limfogranulematozom s porazheniem tsentral'noĭ nervnoĭ sistemy.