Learning in mature mice (Peromyscus leucopus) subjected to deep hypothermia as neonates.
In certain species of nonhibernating rodents, although young nestlings cease breathing and heart action when their body temperature is lowered to near freezing, the nestlings need only be rewarmed to recover. This remarkable capacity for immediate recovery has been known many years, but long-range consequences of deep neonatal hypothermia have never before been investigated. Mice (Peromyscus leucopus) that had been exposed to four 2.5-hr episodes of deep (2-4 degrees C) hypothermia when 4-10 days old were later compared with littermate controls in their performance on two learning tasks. The two groups did not differ in their acquisition or extinction of a lithium-induced learned taste aversion to sucrose. Nor did they differ in learning to find a hidden platform in a swimming pool. Thus in a nonhibernating rodent species, deep hypothermia experienced neonatally--unlike similar hypothermia administered in adulthood--seems not to induce deficits in subsequent learning capabilities. The resistance of neonates to damage probably represents an adaptation, for their modest thermoregulatory abilities render them vulnerable to deep hypothermia in frigid environments.
Hill
Richard W
RW
Michigan State U, East Lansing.
Eshuis
Randal K
RK
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001362:Avoidance Learning / Q000502:physiology; D001833:Body Temperature Regulation; D001921:Brain / Q000502:physiology*; D003080:Cold Temperature / Q000009:adverse effects; D005260:Female; D007858:Learning / Q000502:physiology*; D008297:Male; D009949:Orientation / Q000502:physiology; D010542:Peromyscus / Q000502:physiology*; D013649:Taste / Q000502:physiology