title: The tissue reactions of mice to infection with Heligmosmoides polygyrus.
abstract: The intestines of normal and resistant LAF1 mice were subjected to histologic study to determine the timing and mechanisms of resistance to reinfection by Heligmosmoides polygyrus. During reinfection third-stage larvae are less able to penetrate the intestinal wall. Larvae which are able to encyst develop at a slower rate and provoke an increase in nonspecific inflammation around their cysts. After emergence from intestinal cysts, preadults are rapidly lost, but at no time were injured or destroyed larvae or adults noted. Exsheathed larvae were injected via tail vein into control, sensitized and resistant BALB/c mice. The inflammatory response around entrapped larvae in the lung was measured at 1, 2, 4, and 8 days. A heightened inflammatory response, consisting primarily of polymorphonuclear cells with some round cells which peaked in size on day 2, was observed in both sensitized and resistant mice. A similar heightened inflammatory response was also observed in both AKR (non-resistant) BALB/c (resistant) mice vaccinated subcutaneously with exsheathed larvae.
authors: Department of Veterinary Microbiology, Immunology and Parasitology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14850.
authors: R H
authors: RH
authors: Cypess
authors: H L
authors: HL
authors: Lucia
authors: H A
authors: HA
authors: Dunsford
authors: F J
authors: FJ
authors: Enriquez
mesh_terms: D000818:Animals; D005260:Female; D007113:Immunity, Innate; D007249:Inflammation; D007422:Intestines / Q000469:parasitology / Q000473:pathology*; D007814:Larva; D008168:Lung / Q000469:parasitology / Q000473:pathology*; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D009349:Nematode Infections / Q000276:immunology / Q000469:parasitology / Q000473:pathology*; D009351:Nematospiroides dubius / Q000276:immunology / Q000502:physiology