Hepatic failure toxins depress liver regenerative enzymes after periportal injury with allyl alcohol in the rat.
Hepatic regenerative enzyme (thymidine kinase and ornithine decarboxylase) activities were significantly depressed by subcoma doses of the hepatic failure toxins (NH4+, octanoic acid, and dimethyl disulfide) after selective injury with allyl alcohol. The inhibitory effect of NH4+ was greater than that of dimethyl disulfide, even though the neurologic effects of dimethyl disulfide were approximately comparable with those of the NH4+. There appeared to be a delay in the full expression of the depressive effects of octanoic acid and dimethyl disulfide. The resistance to these two toxins, particularly dimethyl disulfide, may reflect the resistance to injury of the oxidative processes prominent in periportal hepatocyte mitochondria. In comparison with pericentral injury or two-lobe hepatectomy, periportal injury seemed equally susceptible to regenerative enzyme inhibition by NH4+ but less susceptible to the effect of octanoic acid and dimethyl disulfide.
Zieve
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Department of Medicine, Hennepin County Medical Center, Minneapolis, MN 55415.
Anderson
W R
WR
LaFontaine
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D
D000641:Ammonia / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002210:Caprylates / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury; D008107:Liver Diseases / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009955:Ornithine Decarboxylase / Q000378:metabolism; D020005:Propanols; D051381:Rats; D011919:Rats, Inbred Strains; D013440:Sulfides / Q000494:pharmacology*; D013937:Thymidine Kinase / Q000378:metabolism
D002210:Caprylates; D020005:Propanols; D013440:Sulfides; C006463:allyl alcohol; D000641:Ammonia; D013937:Thymidine Kinase; D009955:Ornithine Decarboxylase; C031492:octanoic acid; C004784:dimethyl sulfide