Effective separation of normal, acutely ischemic, and reperfused myocardium with P-31 MR spectroscopy.
The ability of phosphorus-31 magnetic resonance (MR) spectroscopy to accurately characterize myocardium as normal, ischemic, or reperfused but viable was examined in the canine model of acute coronary artery occlusion. P-31 MR measurements of in vivo myocardial pH, phosphocreatine, adenosine triphosphate, and inorganic phosphate levels were made at baseline and for 6 hours after sustained coronary occlusion (ten animals) or coronary occlusion reperfused after 60 minutes (12 animals). Ten control animals were studied in parallel fashion, without coronary occlusion. Myocardial tissue characterization derived from the P-31 MR spectroscopy data by logistic regression analysis had an overall accuracy of 89%. Overall accuracy was unaffected by duration between coronary occlusion and P-31 MR study. Thus, metabolic data obtained with P-31 MR spectroscopy effectively separate normal, acutely ischemic, and reperfused but viable myocardium.
Rehr
R B
RB
Department of Radiology, Virginia Commonwealth University Health Sciences Division, Medical College of Virginia, Richmond 23298-0001.
Tatum
J L
JL
Hirsch
J I
JI
Wetstein
L
L
Clarke
G
G
D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D003326:Coronary Circulation; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D009206:Myocardium / Q000032:analysis / Q000473:pathology; D010710:Phosphates / Q000032:analysis; D010725:Phosphocreatine / Q000032:analysis; D012044:Regression Analysis
D010710:Phosphates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate