On a new class of mixed-function drugs associating nitroimidazoles and CENU: the NICE-NU.
Two series of (2-chloroethyl) nitrosoureas (NICE-NU) bearing a nitroimidazole group have been synthesized for anti-tumor evaluation with the aim of chemopotentiation of their biological activity. Their anti-tumor activity against L1210 in vivo in mice is excellent especially for the series A derivatives where a hydroxy function provides assistance to decomposition. However, the activity of NICE-NU against B16 melanoma is lower.
Carminati
A
A
Laboratoire de Chimie Bio-Organique, UA au CNRS, USTL, France, Montpellier.
Barascut
J L
JL
Chenut
E
E
Bourut
C
C
Mathé
G
G
Imbach
J L
JL
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007939:Leukemia L1210 / Q000188:drug therapy; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D009593:Nitroimidazoles; D009603:Nitroso Compounds; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D009593:Nitroimidazoles; D009603:Nitroso Compounds; C041148:N-(2-chloroethyl)-N-nitrosoacetamide