Selective effects of PHA on rat brush border hydrolases along the crypt-villus axis.
The mechanism of the toxicity of lectin from Phaseolus vulgaris seeds has been investigated on rat enterocytes. Cell isolation procedures showed a selectivity in the loss of brush border hydrolases; this indicated that the microvilli blebbing was not the only mechanism of action of lectins on rat enterocytes.
Rouanet
J M
JM
Laboratoire de Physiologie de la Nutrition, Centre de Génie et Technologie Alimentaires, Montpellier, France.
Lafont
J
J
Zambonino-Infante
J L
JL
Besançon
P
P
D000818:Animals; D004386:Duodenum / Q000201:enzymology; D006867:Hydrolases / Q000378:metabolism*; D007422:Intestines / Q000201:enzymology*; D008297:Male; D008871:Microvilli / Q000201:enzymology*; D010835:Phytohemagglutinins / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D010835:Phytohemagglutinins; D006867:Hydrolases