title: Osmotic dependence of the lysophosphatidylcholine lytic action on liposomes in the gel state.
abstract: Multilamellar liposomes of dimyristoylphosphatidylcholine are susceptible to lytic action of lysophosphatidylcholine at the gel state, an effect which is not observed when liposomes are in the liquid crystalline state. The lytic action has been found to be enhanced when liposomes are dispersed in hypertonic solutions. On the contrary, hypotonic solutions decreased the effectiveness of the lysolipid. Shrunken liposomes present surface changes as detected by merocyanine 540 and 1-anilinonaphthalene-8-sulfonic acid which can be ascribed to the spontaneous curvature promoted by shrinkage.
authors: Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), La Plata, Argentina.
authors: G A
authors: GA
authors: Senisterra
authors: E A
authors: EA
authors: Disalvo
authors: J J
authors: JJ
authors: Gagliardino
mesh_terms: D004134:Dimyristoylphosphatidylcholine; D005782:Gels; D006982:Hypertonic Solutions; D007038:Hypotonic Solutions; D008081:Liposomes / Q000378:metabolism; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D008823:Micelles; D009243:NAD / Q000378:metabolism; D009995:Osmosis; D013050:Spectrometry, Fluorescence; D013053:Spectrophotometry
chemical_list: D005782:Gels; D006982:Hypertonic Solutions; D007038:Hypotonic Solutions; D008081:Liposomes; D008244:Lysophosphatidylcholines; D008823:Micelles; D009243:NAD; D004134:Dimyristoylphosphatidylcholine