Effects of 4-acetylpyridine on stress ulcer formation in mice.
4-Acetylpyridine, earlier reported by us to be an anticonvulsant, offers long-lasting protection after a single administration against hypothermic restraint stress-induced gastric ulceration in mice. Electroshock convulsions, marginally but not significantly protective against such ulcers themselves, when coupled with 4-acetylpyridine administration fully prevented gastric ulcers from occurring in this murine model of experimentally induced stress.
Hall
A
A
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Bose
R
R
Glavin
G
G
Pinsky
C
C
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D004565:Electroconvulsive Therapy; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D011725:Pyridines / Q000008:administration & dosage / Q000627:therapeutic use*; D012149:Restraint, Physical
D000927:Anticonvulsants; D011725:Pyridines; C055538:4-acetylpyridine