title: Changes in hearing, cardiovascular functions, haemodynamics, upright body sway, urinary catecholamines and their correlates after prolonged successive exposures to complex environmental conditions.
abstract: This study deals with changes in temporary threshold shifts of hearing (TTS2), cardiovascular functions (HR, SBP, DBP, PP, RWA), haemodynamic activity (HDI), upright body sway (VUBSA), ratios of urinary catecholamines (10A/DA, 10NA/DA, A/NA, NA/A) and correlations between these changes in complex exposure situations. The study was carried out in a special exposure chamber on 60 healthy male students. It was based on a factorial experimental design with a total of 12 exposure combinations. Each individual experiment took 6 h with a pause of 1 h at noon. There were 12 sequential exposure periods lasting 16 min each. A pause of 4 min followed each exposure period. The subjects were exposed to noise and whole body vibration at two different dry bulb temperatures. Noise classes were: (1) no noise, and (2) stable broad-band noise of 90 dBA. Vibration classes were: (1) no vibration, (2) a sinusoidal 5 Hz vibration, and (3) a stochastic vibration with a frequency range of 2.8 to 11.2 Hz along the Z-axis and with an acceleration of 2.12 m/s2. Temperature classes were: (1) 20 degrees C and (2) 35 degrees C. Changes in body functions were registered during the pauses. Urine samples were gathered for the morning and afternoon sessions and for the preceding and the following night of the test. The changes were dependent on the combinations of noise, vibration and temperature to which the subjects were exposed. The TTS2 values at 4 kHz were associated with the HDI-values when subjects were exposed simultaneously to noise and stochastic vibration at 35 degrees C. The TTS2 values at 6 kHz were associated most strongly with the HDI values after exposure to a combination of noise, stochastic or sinusoidal vibration and a temperature of 20 degrees C. The TTS2 values at 4 and 6 kHz correlated positively with the NA/A ratio when subjects were exposed to noise at 35 degrees C. The association between TTS2 values and the 10A/NA ratio and especially the A/NA ratio was very strong when subjects had been simultaneously exposed to noise and sinusoidal or stochastic vibration at 35 degrees C. Furthermore, the highest positive correlation coefficients were found between TTS2 values at 4 kHz and VUBSA values in the X-direction when subjects had been exposed to noise or simultaneously to noise and sinusoidal vibration at 20 degrees C.(ABSTRACT TRUNCATED AT 400 WORDS)
authors: Academy of Finland, Department of Public Health, Faculty of Medicine, University of Tampere.
authors: O
authors: O
authors: Manninen
mesh_terms: D000328:Adult; D001299:Audiometry; D002395:Catecholamines / Q000652:urine*; D002940:Circadian Rhythm; D004231:Diuresis; D004781:Environmental Exposure; D006439:Hemodynamics; D006358:Hot Temperature; D006801:Humans; D008297:Male; D009622:Noise / Q000009:adverse effects*; D011187:Posture; D011897:Random Allocation; D014732:Vibration / Q000009:adverse effects*
chemical_list: D002395:Catecholamines