'Revised' mass spectral identification of 2-amino-4-(5-nitro-2-furyl)thiazole metabolites.
The electron ionization mass spectra of 2-amino-4-(5-nitro-2-furyl)thiazole metabolites obtained from microsomal incubations and chemical syntheses were studied. The identities of the metabolites were established by chemical ionization, high resolution, and metastable measurements. The compounds studied showed multiple modes of cleavage, skeletal rearrangements and hydrogen back-transfer.
Mattammal
M B
MB
Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, St Louis, Missouri.
Lakshmi
V M
VM
Zenser
T V
TV
Davis
B B
BB
White
E
E
D000818:Animals; D002273:Carcinogens / Q000032:analysis* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005200:FANFT / Q000031:analogs & derivatives / Q000032:analysis* / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D066298:In Vitro Techniques; D008297:Male; D013058:Mass Spectrometry; D008861:Microsomes / Q000378:metabolism; D010084:Oxidation-Reduction; D012756:Sheep; D013844:Thiazoles / Q000032:analysis*
D002273:Carcinogens; D013844:Thiazoles; C024885:ANFT; D005200:FANFT