Long-term results in 64 patients operated upon for pheochromocytoma.
During the years 1956-1982, 64 pheochromocytoma patients were operated upon without mortality. Twenty-eight patients had sustained hypertension and 29 paroxysmal hypertension only. In two patients high blood pressure was not related to pheochromocytoma and five subjects were normotensive. In two women the pheochromocytoma demonstrated malignancy by widespread metastases. Sixteen patients also had neuroectodermal manifestations other than pheochromocytoma. Preoperatively, heart disease was found in most of the hypertensive patients aged 50 years or more at operation, but was uncommon in the others. In these subjects, heart disease persisted after surgery. Young subjects with sustained hypertension were not less affected by preoperative cerebrovascular accidents than older subjects. After surgery, hypertension persisted in 12 patients, and was easily controlled by drug therapy in eight. Nine patients died 7 months-18 years after surgery. In no case was the death directly associated with the pheochromocytoma disease. Three died from other neuroectodermal abnormalities. The 55 surviving patients have been followed up for a mean of 12 years after surgery. During the observation time the survival of the pheochromocytoma patients was similar to that of the normal population. At the end of the study, 44 out of the 55 surviving patients were free from symptoms.
Stenström
G
G
Department of Medicine II, Sahlgrenska Hopital, University of Göteborg, Sweden.
Ernest
I
I
Tisell
L E
LE
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000401:mortality / Q000601:surgery*; D000328:Adult; D000367:Age Factors; D000368:Aged; D001795:Blood Pressure Determination; D002561:Cerebrovascular Disorders / Q000209:etiology*; D004700:Endocrine System Diseases / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000150:complications / Q000401:mortality / Q000601:surgery*; D011379:Prognosis