Hydroxyprolinuria and hypercalcaemia during immobilization in patients with idiopathic myelofibrosis.
Two of three patients with bone pains and hydroxyprolinuria due to idiopathic myelofibrosis developed hypercalcaemia during periods of immobilization. This responded rapidly to cytotoxic therapy with busulphan. Hydroxyproline excretion in the urine was increased compared to ambulant patients with the same disease. These previously unreported findings suggest that immobilization can produce rapid, generalized bone resorption in patients with myelofibrosis.
Baglin
T P
TP
Haematology Department, Queen Elizabeth Hospital, Birmingham.
Boughton
B J
BJ
D000328:Adult; D003094:Collagen / Q000378:metabolism; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D006934:Hypercalcemia / Q000097:blood / Q000209:etiology* / Q000652:urine; D007103:Immobilization; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000097:blood / Q000150:complications* / Q000652:urine
D003094:Collagen; D006909:Hydroxyproline