Hydroxylation and oxidation of nalidixic acid in the turtle Pseudemys scripta elegans.
The turtle Pseudemys scripta elegans hydroxylates nalidixic acid into 7-hydroxynalidixic acid; this latter metabolite is oxidised into 7-carboxynalidixic acid. The elimination half-life of nalidixic acid in the turtle is 30 h. No glucuronides of nalidixic- and 7-hydroxynalidixic acid are formed, as they are in man.
Vree
T B
TB
Department of Clinical Pharmacy, Sint Radboud Hospital, University of Nijmegen, The Netherlands.
Vree
J B
JB
Baars
A M
AM
Nouws
J F
JF
Hekster
Y A
YA
D000818:Animals; D006900:Hydroxylation; D009268:Nalidixic Acid / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000378:metabolism*; D010084:Oxidation-Reduction; D014426:Turtles / Q000378:metabolism*
C012368:7-hydroxynalidixic acid; D009268:Nalidixic Acid