title: Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains.
abstract: Competition experiments using (-)-[3H]nicotine and unlabelled nicotine revealed both high and low affinity nicotinic binding sites in temporal cortex of control and Alzheimer (AD/SDAT) brains. A significant reduction in the proportion of high affinity nicotinic binding sites (-20%) and a parallel increase in the proportion of low affinity nicotinic binding sites was obtained in AD/SDAT brain cortex compared to control brain. Moreover, a marked decrease was observed in the affinity of the low affinity nicotinic binding sites in AD/SDAT.
authors: Department of Pharmacology, University of Uppsala, Sweden.
authors: A
authors: A
authors: Nordberg
authors: A
authors: A
authors: Adem
authors: J
authors: J
authors: Hardy
authors: B
authors: B
authors: Winblad
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009538:Nicotine / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000145:classification / Q000378:metabolism*; D013702:Temporal Lobe / Q000378:metabolism*
chemical_list: D011978:Receptors, Nicotinic; D009538:Nicotine