Alkaline phosphatase positive precursors of adipocytes in the human bone marrow.
Developing fat cells in the bone marrow of leukaemic patients treated with chemotherapy were found to be endowed with membrane-bound alkaline phosphatase. Since alkaline phosphatase is a cytochemical marker of 'reticular' cells, this observation provides cytochemical evidence that reticular cells may convert to adipocytes when marrow cellularity abruptly decreases.
Bianco
P
P
Department of Human Biopathology, La Sapienza University, Rome, Italy.
Costantini
M
M
Dearden
L C
LC
Bonucci
E
E
D000208:Acute Disease; D000273:Adipose Tissue / Q000201:enzymology*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D001853:Bone Marrow / Q000473:pathology*; D006801:Humans; D007938:Leukemia / Q000201:enzymology / Q000473:pathology*
D000469:Alkaline Phosphatase