The acrocallosal syndrome.
The acrocallosal syndrome is characterized by peculiar facies, polydactyly of the hands and/or feet, and agenesis of the corpus callosum. Two unrelated 4-month-old boys with consanguineous parents are reported. Both exhibited the main features of the syndrome, but neither of them had partial reduplication of halluces. Consequently, pre-axial polydactyly of the feet is not considered to be a constant feature of the acrocallosal syndrome. The similarity of the acrocallosal syndrome to Greig syndrome is discussed, but it appears unlikely that the two syndromes are identical. Consanguinity in both cases is a strong argument in favour of a recessive mode of inheritance.
Philip
N
N
INSERM U.242, Hôpital d-Enfants de la Timone, Marseille, France.
Apicella
N
N
Lassman
I
I
Ayme
S
S
Mattei
J F
JF
Giraud
F
F
D061085:Agenesis of Corpus Callosum; D003241:Consanguinity; D005149:Facial Expression; D005532:Foot Deformities, Congenital / Q000150:complications / Q000235:genetics; D005808:Genes, Recessive; D006228:Hand Deformities, Congenital / Q000150:complications / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D013577:Syndrome