5-hydroxytryptamine inhibits cholinergic transmission through 5-HT1A receptor subtypes in rabbit vesical parasympathetic ganglia.
Intracellular recordings were made from parasympathetic neurons of the rabbit vesical pelvic ganglia (VPG) maintained in vitro. 5-Hydroxytryptamine (5-HT) inhibited cholinergic transmission in the VPG by reducing the fast excitatory postsynaptic potential (EPSP) evoked by stimulations of pelvic nerves. 8-Hydroxy-2-(di-n-propyl-amino) tetralin hydrochloride mimicked the inhibitory effect of 5-HT on the ganglionic transmission. 5-HT-induced inhibition of the fast EPSP was antagonized by spiperone. The results suggest that 5-HT1A receptor subtypes mediate the inhibition of cholinergic transmission in the rabbit VPG.
Nishimura
T
T
Department of Physiology, Kurume University School of Medicine, Japan.
Tokimasa
T
T
Akasu
T
T
D000818:Animals; D005726:Ganglia, Parasympathetic / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology*; D013569:Synapses / Q000502:physiology
D011985:Receptors, Serotonin; D012701:Serotonin