Intraperitoneal flucytosine in the management of fungal peritonitis in patients on continuous ambulatory peritoneal dialysis.
Five episodes of fungal peritonitis were treated by intraperitoneal instillation of 5-flucytosine (5-Fc) while the patients remained on their usual schedule of dialysis. Therapeutic, nontoxic dialysate and serum concentrations of 5-Fc were achieved. Although some patients transiently responded with improved symptoms, a drop in their dialysate WBC count and negative cultures, all patients required removal of their dialysis catheters for cure. It is concluded that intraperitoneal (IP) 5-Fc, as used in this study, is not efficacious in the treatment of fungal peritonitis.
Eisenberg
E S
ES
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY.
D002177:Candidiasis / Q000188:drug therapy* / Q000209:etiology; D005437:Flucytosine / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007322:Instillation, Drug; D010529:Peritoneal Cavity; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology
D005437:Flucytosine