Influence of sodium balance on uremic red blood cell ion transport.
This study was performed to test the effect of dialysis-induced acute modifications of plasma volume and sodium pool on red blood cell (RBC) ion transport in patients with end-stage renal disease. This approach confirmed the presence of an Na-K pump inhibitor in the plasma of uremic patients with extracellular fluid volume expansion. This factor cross-reacts with digoxin antibodies, and its concentration decreases during dialysis; this explains the increased activity of the RBC Na-K pump that is consistently observed during dialysis.
Krzesinski
J M
JM
Department of Internal Medicine, University of Liège, CHU Sart Tilman, Belgium.
Rorive
G
G
D000328:Adult; D001693:Biological Transport, Active; D001810:Blood Volume; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood; D008297:Male; D006435:Renal Dialysis; D012964:Sodium / Q000097:blood*; D014511:Uremia / Q000097:blood*
D012964:Sodium