Effect of combined treatment of anti-inflammatory drug and mannoheptulose on the production of tumour necrosis factor and endotoxin shock in mice.
The endotoxin shock induced in mice by injection of viable Listeria monocytogenes and challenged with endotoxin can be alleviated by combined administration of mannoheptulose with acetylsalicylate or sulindac. The ability of animals to secrete tumour necrosis factor into the blood was, however, not affected. The significance of these observations are discussed.
Fung
K P
KP
Department of Biochemistry, Chinese University of Hong Kong, Shatin.
Cheng
C P
CP
Luey
L U
LU
Loh
S C
SC
Choy
Y M
YM
Lee
C Y
CY
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006539:Heptoses / Q000008:administration & dosage*; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D008356:Mannoheptulose / Q000008:administration & dosage*; D051379:Mice; D008813:Mice, Inbred ICR; D012772:Shock, Septic / Q000517:prevention & control*; D013467:Sulindac / Q000008:administration & dosage; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D000893:Anti-Inflammatory Agents; D006539:Heptoses; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D013467:Sulindac; D008356:Mannoheptulose; D001241:Aspirin