Mononuclear cells from rheumatoid arthritis patients exhibit a depressed IgM response to sheep erythrocyte stimulation in vitro.
Human peripheral blood mononuclear cells when cultured for the short term (11 days) produce an optimal IgM plaque-forming cell (PFC) response to sheep erythrocytes, which is dependent on macrophages and T suppressor and helper lymphocytes. With this system we have investigated the PFC response of individuals with rheumatoid arthritis and compared this to the response of normal sex- and age-matched controls and of patients with osteoarthritis. The response of rheumatoid arthritis patients was significantly lower than that of subjects in the other two categories.
Gabrielli
A
A
Department of Pathology, Medical University of South Carolina, Charleston 29425.
Silver
R
R
Teti
G
G
Chiofalo
M S
MS
Misefari
A
A
Venza-Teti
D
D
Virella
G
G
La Via
M F
MF
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis*; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D012756:Sheep
D007075:Immunoglobulin M