Association of closure of patent ductus arteriosus and development of necrotizing enterocolitis.
Over a 5-year period ending in June 1986, 234 neonates with evidence of a significant patent ductus arteriosus (PDA) underwent ductal manipulation. Thirty-four infants (15%) developed evidence of necrotizing enterocolitis (NEC). When NEC and treatment of PDA were within 72 hours of each other, there was a 71% mortality rate. When NEC and PDA ligation were greater than 72 hours apart, there were no deaths. Development of NEC prior to ductal closure was associated with a mortality of 57%, as opposed to no mortality when the development of NEC occurred after ductal closure. Our data suggest that infants who develop NEC before PDA ligation incur a high mortality.
Palder
S B
SB
Department of Surgery, University of California, Davis, School of Medicine, Sacramento 95817.
Schwartz
M Z
MZ
Tyson
K R
KR
Marr
C C
CC
D001724:Birth Weight; D004374:Ductus Arteriosus, Patent / Q000150:complications* / Q000601:surgery; D004761:Enterocolitis, Pseudomembranous / Q000150:complications* / Q000401:mortality; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases; D011379:Prognosis; D013997:Time Factors