New paulomycins produced by Streptomyces paulus.
Paulomycin A2 (C34H46N2O17S), paulomycin C (C32H42N2O17S), paulomycin D (C31H40N2O17S), paulomycin E (C29H36N2O16S) and paulomycin F (C29H38N2O16S) have been isolated from fermentations of Streptomyces paulus strain 273. The structure of these compounds was determined using NMR and mass spectroscopic techniques. The new paulomycins, like paulomycins A and B (J. Antibiotics 35: 285-294, 1982) are highly active mainly against Gram-positive organisms.
Argoudelis
A D
AD
Upjohn Company, Kalamazoo, Michigan 49001.
Baczynskyj
L
L
Haak
W J
WJ
Knoll
W M
WM
Mizsak
S A
SA
Shilliday
F B
FB
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D053138:Cyclohexenes; D004187:Disaccharides / Q000302:isolation & purification / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D053138:Cyclohexenes; D004187:Disaccharides; C055554:paulomycin D; C055552:paulomycin A2; C055555:paulomycin E; C055553:paulomycin C; C055556:paulomycin F; C034570:paulomycin B; C034569:paulomycin A