Neuropeptide Y stimulates inositol phospholipid hydrolysis in rat brain miniprisms.
Neuropeptide Y (NPY) stimulates the hydrolysis of inositol phospholipid in rat brain miniprisms. The stimulation was two-fold in the frontal cortex and in the hippocampus, and 1.5-fold in the striatum. NPY produced no significant effects on basal inositol monophosphate levels in hypothalamic miniprisms. However, those basal levels were much higher than in the other brain regions.
Hinson
J
J
American Cyanamid Company, Medical Research Division, Lederle Laboratories, Pearl River, NY 10965.
Rauh
C
C
Coupet
J
J
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D006868:Hydrolysis; D007295:Inositol Phosphates / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology*; D009479:Neuropeptides / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013403:Sugar Phosphates / Q000378:metabolism*
D007295:Inositol Phosphates; D009478:Neuropeptide Y; D009479:Neuropeptides; D013403:Sugar Phosphates