title: Piston-pump-type high frequency oscillatory ventilation for neonates with congenital diaphragmatic hernia: a new protocol.
abstract: High frequency ventilation and extracorporeal membrane oxygenation (ECMO) are devices that are expected to save the lives of newborn infants whose pulmonary conditions have deteriorated. A piston-pump-type high-frequency oscillator (HFO), developed by Bryan and Miyasaka called "Hummingbird," is considered to be superior to high frequency "jet" ventilators or those of the flow-interrupter type, and was used successfully in two neonates with congenital diaphragmatic hernia (CDH) in a high-risk group. The first baby was on a conventional ventilator with pharmacologic support for the first 54 hours and then operated on. Postoperative deterioration necessitated the use of HFO for the next eight days. The infant then recovered uneventfully. For the second baby, HFO was necessary both preoperatively and postoperatively. This baby had a major diaphragmatic defect and her case was complicated with pneumothorax. There was a long stormy course on HFO (total, 70 days), but the patient was successfully extubated on the 75th day postoperatively and is now doing well. We believe active long preoperative stabilization with pharmacologic support and preoperative and postoperative hyperventilation with a piston-pump-type HFO may be a new innovative strategy for the management of severe CDH patients.
authors: Department of Surgery, National Children's Hospital, Tokyo, Japan.
authors: M
authors: M
authors: Tamura
authors: Y
authors: Y
authors: Tsuchida
authors: T
authors: T
authors: Kawano
authors: T
authors: T
authors: Honna
authors: R
authors: R
authors: Ishibashi
authors: T
authors: T
authors: Iwanaka
authors: Y
authors: Y
authors: Morita
authors: H
authors: H
authors: Hashimoto
authors: H
authors: H
authors: Tada
authors: K
authors: K
authors: Miyasaka
mesh_terms: D005260:Female; D006548:Hernia, Diaphragmatic / Q000150:complications / Q000601:surgery; D065630:Hernias, Diaphragmatic, Congenital; D006612:High-Frequency Ventilation / Q000295:instrumentation; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010547:Persistent Fetal Circulation Syndrome / Q000209:etiology; D011183:Postoperative Complications; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy