Recovery of cutaneous immune responsiveness after PUVA therapy.
We studied sensitization to dinitrochlorobenzene (DNCB) in psoriatic patients before, during and 2, 4, and 6 weeks after a course of photochemotherapy (PUVA). The inhibition of sensitivity observed during PUVA was completely reversed after 6 weeks. Thus the PUVA-mediated inhibition of cutaneous immune responsiveness is of short duration. However, whether there are long-term sequelae remains to be established.
White
S I
SI
Department of Dermatology, University of Newcastle upon Tyne, U.K.
Friedmann
P S
PS
Moss
C
C
Simpson
J M
JM
D004137:Dinitrochlorobenzene / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed; D007114:Immunization; D008297:Male; D011701:PUVA Therapy; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology; D012867:Skin / Q000276:immunology*; D013997:Time Factors
D004137:Dinitrochlorobenzene