Cystatin C containing neurons in human postmortem hypothalamus.
The regional distribution and cellular localization of cystatin C in neurons of human postmortem hypothalamic was studied by use of peroxidase-anti-peroxidase technique. Cystatin C (earlier named gamma-trace) was found to be present in multiple nerve cells belonging to nuclei supraopticus, paraventricularis and arcuatus. We speculate that the occurrence of cystatin C in human cerebrospinal fluid is the result of a release of the protein from these neurons into the ventricular system.
Bernstein
H G
HG
Institute of Anatomy, Medical Academy, Magdeburg, G.D.R.
Järvinen
M
M
Pöllänen
R
R
Schirpe
H
H
Knöfel
B
B
Rinne
R
R
D000368:Aged; D000369:Aged, 80 and over; D002556:Cerebrospinal Fluid Proteins; D055316:Cystatin C; D015891:Cystatins; D006801:Humans; D007031:Hypothalamus / Q000032:analysis*; D007150:Immunohistochemistry; D011180:Postmortem Changes; D011506:Proteins / Q000032:analysis*
C525030:CST3 protein, human; D002556:Cerebrospinal Fluid Proteins; D055316:Cystatin C; D015891:Cystatins; D011506:Proteins