title: [A new theorem in the theory of metabolism regulation: how external parameters control the flow and concentration of metabolites].
abstract: A simple theorem is derived concerning "global" and "local" coefficients of metabolic network. The coefficients of the flux and concentration response to changes in the external parameters (temperature, ionic strength, pH, external effectors) are considered. These coefficients are expressed through the sum of the control coefficients multiplied by the elasticity coefficients for all the enzymes of the metabolic pathway.
authors: B N
authors: BN
authors: Kholodenko
mesh_terms: D008433:Mathematics; D008660:Metabolism; D008954:Models, Biological
vernacular_title: Novaia teorema teorii reguliatsii metabolizma: kak vneshnie parametry upravliaiut potokami i kontsentratsiiami metabolitov.