[Disorders of the dynamics of postnatal development of monoamine oxidase activity in the brain as affected by the antenatal action of alcohol].
The activity of different types of monoamine oxidase (MAO)-MAO, type A (substrate serotonin) and two types of mixed MAO forms using tyramine or dopamine as substrates, in different brain regions of the rat offspring exposed prenatally to ethanol was investigated on the 30th and 60th day postnatally. The present study has revealed differences in the development of brain MAO activity during ontogenesis. Disturbances in the activity of all MAO types investigated as well as the distortion of their postnatal development have been observed in the brain of the rat offspring exposed prenatally to ethanol. The possible teratogenic effect of ethanol on the developing fetal brain is discussed.
Uzbekov
M G
MG
Moshanskaia
M A
MA
D000818:Animals; D001921:Brain / Q000002:abnormalities / Q000201:enzymology* / Q000254:growth & development; D004298:Dopamine; D000431:Ethanol; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D012701:Serotonin; D013723:Teratogens; D014439:Tyramine
D013723:Teratogens; D012701:Serotonin; D000431:Ethanol; D008995:Monoamine Oxidase; D004298:Dopamine; D014439:Tyramine
Izvrashchenie dinamiki postnatal'nogo razvitiia aktivnosti monoaminoksidazy v golovnom mozge pri antenatal'nom vozdeĭstvii alkogolia.