The ultrastructure of transitional cell carcinomas of the human urinary bladder treated with ethoglucid or mitomycin.
Electron microscopy studies of the ultrastructure of bladder carcinoma treated by intravesical instillation of ethoglucid and mitomycin are described. Ethoglucid acts mainly by disrupting cells' intercellular bonds. Mitomycin acts on the cell nucleus. It is suggested that these differences in action form a basis for sequential therapy.
Stewart
R J
RJ
Section of Urology, University of Dundee, Scotland, United Kingdom.
Lawson
A H
AH
Weaver
J P
JP
D000283:Administration, Intravesical; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000648:ultrastructure*; D004987:Ethers / Q000627:therapeutic use*; D005009:Ethoglucid / Q000627:therapeutic use*; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D008937:Mitomycins / Q000627:therapeutic use*; D001743:Urinary Bladder / Q000648:ultrastructure*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000648:ultrastructure*
D004987:Ethers; D008937:Mitomycins; D005009:Ethoglucid