Effects of laboratory-induced panic-anxiety on subsequent provocative infusions.
The effects of infusion-induced panic-anxiety on subsequent pre-infusion anxiety ratings and infusion-induced panic attacks were studied in 64 panic disorder patients, in a double-blind randomized study using sodium lactate, isoproterenol, and placebo infusions. While there was a decrease of preinfusion anxiety from one infusion to the next infusion both for panickers and nonpanickers, there was no evidence of either a significant decrease or an increase in the frequency of subsequent panic attacks. These results suggest that there is neither a desensitizing nor a sensitizing effect of pharmacologically induced panic attacks on subsequent infusions in a serial three-infusion design.
Yeragani
V K
VK
Outpatient Department, Lafayette Clinic, Detroit, MI 48207.
Balon
R
R
Rainey
J M
JM
Ortiz
A
A
Berchou
R
R
Lycaki
H
H
Pohl
R
R
D000328:Adult; D001007:Anxiety / Q000523:psychology; D001008:Anxiety Disorders / Q000139:chemically induced*; D004311:Double-Blind Method; D005239:Fear / Q000187:drug effects*; D005260:Female; D006801:Humans; D007545:Isoproterenol; D007773:Lactates; D019344:Lactic Acid; D008297:Male; D010200:Panic / Q000187:drug effects*; D011897:Random Allocation; D012008:Recurrence
D007773:Lactates; D019344:Lactic Acid; D007545:Isoproterenol