[Influence of kordaron, anaprilin, dimedrol and riboxin on the hemodynamic effects of strophanthin in experimental heart failure].
In experiments on 183 rats it was shown that cordarone, anapriline, dimedrol and riboxine increasing in experimental cardiac insufficiency tolerance to the cardiotoxic effect of strophanthin differ significantly by their influence on the hemodynamic effects of this cardiac glycoside. Cordarone increased intensity of the hemodynamic effects of strophanthin and accelerated their development. Under the action of anapriline and dimedrol the stimulating effect of strophanthin on hemodynamics decreased to a much lesser degree than its cardiotoxicity. Riboxine virtually abolished the hemodynamic effects of strophanthin.
Gendenshteĭn
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EI
Lemkina
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D000638:Amiodarone / Q000627:therapeutic use*; D000818:Animals; D004155:Diphenhydramine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D006333:Heart Failure / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D007290:Inosine Diphosphate / Q000627:therapeutic use*; D007292:Inosine Nucleotides / Q000627:therapeutic use*; D007545:Isoproterenol / Q000633:toxicity; D011433:Propranolol / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013328:Strophanthins / Q000633:toxicity*
D007292:Inosine Nucleotides; D013328:Strophanthins; D007290:Inosine Diphosphate; D004155:Diphenhydramine; D011433:Propranolol; D007545:Isoproterenol; D000638:Amiodarone; C029082:strophanthin K
Vliianie kordarona, anaprilina, dimedrola i riboksina na gemodinamicheskie éffekty strofantina pri éksperimental'noĭ serdechnoĭ nedostatochnosti.