Early release of glia maturation factor and acidic fibroblast growth factor after rat brain injury.
A major component of the healing response of the brain to injury is the induction of growth and trophic factors. In the rat brain, glia maturation factor (GMF) and acidic fibroblast growth factor (aFGF) are not extracellular. However, within the first hour following brain injury, the amount of GMF and aFGF in the wound cavity increased by 7- and 13-fold, respectively, compared to the tissue adjacent to the wound. A cascade of cellular and biochemical events, leading to glial proliferation, the arrest of secondary neuronal death and axonal sprouting, may be initiated by the sudden increase in the extracellular concentration of these factors.
Nieto-Sampedro
M
M
Department of Psychobiology, University of California, Irvine 92717.
Lim
R
R
Hicklin
D J
DJ
Cotman
C W
CW
D000818:Animals; D000911:Antibodies, Monoclonal; D001930:Brain Injuries / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D005781:Gelatin Sponge, Absorbable; D020904:Glia Maturation Factor; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014020:Tissue Extracts / Q000032:analysis
D000911:Antibodies, Monoclonal; D020904:Glia Maturation Factor; D009419:Nerve Tissue Proteins; D014020:Tissue Extracts; D005346:Fibroblast Growth Factors