In vitro-in vivo correlation exemplified by sustained release formulations of suprofen.
To evaluate some prototype oral sustained release formulations of the analgesic drug suprofen (alpha-methyl-4-(2-thienyl-carbonyl)phenylacetic acid, Suprol) in vitro-in vivo correlations were performed. Numerical deconvolution led to hypothetical in vivo absorption curves which were in close agreement with the in vitro dissolution profiles. Furthermore, a linear correlation was obtained between the in vivo and in vitro mean residence times calculated from the blood level data.
Huguenin
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PN
Cilag Ltd., Pharmaceutical Research and Development, Section Biopharmacy/Pharmacokinetics, Schaffhausen, Switzerland.
Zulliger
H W
HW
Niederer
R
R
D000328:Adult; D003692:Delayed-Action Preparations; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D010666:Phenylpropionates / Q000493:pharmacokinetics*; D012995:Solubility; D013496:Suprofen / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D010666:Phenylpropionates; D013496:Suprofen