Protein kinase C in the regenerating rat liver.
Protein kinase C (PKC) activity in the soluble fraction of regenerating rat liver showed a biphasic decrease prior to the initiation of DNA synthesis. The first decrease was seen at 3-6 h after partial hepatectomy (PH). The second decrease occurred after 14 h and continued until 24 h, while DNA synthesis began 18-20 h and reached peak value 22 h after PH. It is suggested that the soluble PKC in regenerating rat liver is activated and bound to the plasma membrane prior to the initiation of DNA synthesis.
Okamoto
Y
Y
Department of Clinico-Laboratory Diagnostics, Nara Medical University, Japan.
Nishimura
K
K
Nakayama
M
M
Nakagawa
M
M
Nakano
H
H
D000818:Animals; D004261:DNA Replication; D008099:Liver / Q000201:enzymology*; D008115:Liver Regeneration; D008297:Male; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013755:Tetradecanoylphorbol Acetate / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism
D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate; D013936:Thymidine