IgM anti-D as auto-antibody in a case of 'cold' auto-immune haemolytic anaemia.
A case is reported of an auto-immune haemolytic anaemia caused by IgM anti-D. This antibody, although active at 37 degrees C, gave stronger reactions at lower temperatures and appeared to activate complement. The auto-immune haemolytic anaemia was probably secondary to a non-Hodgkins lymphoma.
Longster
G H
GH
Regional Blood Transfusion Centre, Leeds, UK.
Johnson
E
E
D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D003167:Complement Activation; D005260:Female; D006801:Humans; D007072:Immunoglobulin D / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D008875:Middle Aged
D001323:Autoantibodies; D007072:Immunoglobulin D; D007075:Immunoglobulin M