[An autopsied case of pulmonary carcinoma with perforation peritonitis due to metastatic tumor necrosis at the jejunum caused by chemotherapy].
A 76-year-old man with lung carcinoma, who was undergoing both radiotherapy and chemotherapy (CDDP + ADR) suddenly died with the onset of abdominal symptoms. Autopsy disclosed that the main cause of death was suppurative panperitonitis, caused by a perforation of a metastatic lesion at the jejunum. A histological examination revealed extensive tumor necrosis in the metastatic liver lesions as well as in the jejunal lesions. Neither inflammatory nor circulatory damage was observed in the perforated lesion. Therefore, the cause of this perforation was considered to be chemotherapy that had brought on tumor necrosis. No similar reports of lung cancer deaths have been found in the literature in which the microscopic details were described. Accordingly, this case is reported for future reference with regard to cancer chemotherapy.
Hoshino
K
K
1st Dept. of Internal Med., Toyama Medical & Pharmaceutical Univ.
Mizushima
Y
Y
Yano
S
S
Kitagawa
M
M
D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary*; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects; D004317:Doxorubicin / Q000009:adverse effects; D006801:Humans; D007416:Intestinal Perforation / Q000139:chemically induced*; D007579:Jejunal Diseases / Q000139:chemically induced*; D007580:Jejunal Neoplasms / Q000473:pathology / Q000556:secondary*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D009336:Necrosis / Q000473:pathology; D010538:Peritonitis / Q000209:etiology*
D000970:Antineoplastic Agents; D004317:Doxorubicin; D002945:Cisplatin