Influence of the nature of calcium salts on serum calcium, phosphorus, calcitonin, growth hormone, and somatomedin C.
Twenty healthy males were randomly divided into three groups. Each subject received either 405 mg elemental calcium (Ca) as a salt linked to an amino acid precursor, 405 mg CaC12 or 1000 mg Ca as Ca gluconolactate and carbonate. In all three cases, Ca intake led to an increase of serum Ca and TCT production and a decrease of PTH liberation. However, when Ca is linked to the amino acid precursor, an elective stimulation of growth hormone (GH) and somatomedin C (SmC) occurs. Due to the nature of its amino acid precursor, this salt seems to stimulate GH and SmC liberation through hypophysis. This could be a major pathway in decoupling of the sequence resorption-formation and therapy of metabolic bone diseases.
Reginster
J Y
JY
Dept. of Rheumatology and Physical Medicine, University of Liège, Belgium.
Denis
D
D
Albert
A
A
Gaspar
S
S
Heynen
G
G
Deroisy
R
R
Franchimont
P
P
D000328:Adult; D002116:Calcitonin / Q000097:blood*; D002118:Calcium / Q000097:blood* / Q000494:pharmacology; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000097:blood*; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood*; D012492:Salts; D013002:Somatomedins / Q000097:blood*
D010281:Parathyroid Hormone; D012492:Salts; D013002:Somatomedins; D010758:Phosphorus; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D002116:Calcitonin; D002118:Calcium