The carbohydrate composition of human serum amyloid P component.
The carbohydrate moiety of human serum amyloid P component was analyzed and found to consist of equal amounts of galactose and mannose (total 4.0%), of glucosamine and galactosamine in a ratio of 7:1 (total 2.7%) and sialic acid (3.9%). It should be noted that this is the first report on the separate quantification of the neutral hexoses and the demonstration of the presence of galactosamine. The contents of glucosamine and galactosamine suggest that this protein possesses both an N- and an O-glycan.
Hess
D
D
Department of Biochemistry, Boston University School of Medicine, MA 02118.
Ohishi
H
H
Skinner
M
M
Cohen
A S
AS
Schmid
K
K
D002241:Carbohydrates / Q000097:blood*; D005688:Galactosamine / Q000097:blood; D005944:Glucosamine / Q000097:blood; D006601:Hexoses / Q000097:blood; D006801:Humans; D008358:Mannose / Q000097:blood; D019158:N-Acetylneuraminic Acid; D000683:Serum Amyloid P-Component / Q000097:blood*; D012794:Sialic Acids / Q000097:blood
D002241:Carbohydrates; D006601:Hexoses; D000683:Serum Amyloid P-Component; D012794:Sialic Acids; D005688:Galactosamine; D019158:N-Acetylneuraminic Acid; D005944:Glucosamine; D008358:Mannose