Stress-induced occupancy and translocation of hippocampal glucocorticoid receptors.
Using an exchange assay for glucocorticoid receptors, we found that immobilization stress resulted in a approximately 50% translocation of receptors (i.e. receptors assumed to be chromatin bound) from soluble fractions prepared from hippocampal tissue. The increased hormone-receptor signal persisted for about 2-4 h following the termination of the stressor. This time course is consistent with the known temporal pattern for the negative feedback of glucocorticoids on adrenocortical activity.
Meaney
M J
MJ
Douglas Hospital Research Centre, Department of Psychiatry, Faculty of Medicine, McGill University, Canada.
Viau
V
V
Aitken
D H
DH
Bhatnagar
S
S
D000315:Adrenalectomy; D000818:Animals; D002843:Chromatin / Q000378:metabolism; D003907:Dexamethasone / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D012016:Reference Values; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*; D013997:Time Factors
D002843:Chromatin; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone