Long-term sequellae of acetaminophen-associated fulminant hepatic failure: relevance of early histology.
We report a case of fulminant hepatic necrosis occurring in the setting of acetaminophen overdose and chronic alcohol use. The pathology of severe acute toxicity is documented with a surgical biopsy. Follow-up liver biopsy 4 yr later documents hepatic regeneration without cirrhosis. Maintenance of the hepatic reticulin framework in the face of acute hepatic necrosis was well documented, and may be a useful prognostic feature indicating a potential for the maintenance of normal hepatic architecture following regeneration.
Baeg
N J
NJ
Department of Internal Medicine, Catholic Medical College, Seoul, Korea.
Bodenheimer
H C
HC
Burchard
K
K
D000082:Acetaminophen / Q000506:poisoning*; D000208:Acute Disease; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D005500:Follow-Up Studies; D006501:Hepatic Encephalopathy / Q000139:chemically induced; D006801:Humans; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000473:pathology; D008875:Middle Aged; D009336:Necrosis
D000082:Acetaminophen