title: Synthesis of some 1,2,4-triazine derivatives with potential biological activity.
abstract: 6-Substituted benzyl-3-thioxo-1,2,4-triazin-5-ones 5a-e and the 4-amino derivatives 12c, e were prepared and converted into their corresponding 3-methylthio derivatives 6a-e and 13c, e, respectively of compounds 6a-e with primary and secondary amines gave the corresponding 3-amino-1,2,4-triazin-5-ones 7a-i and 8a, b. Cyclocondensation of compounds 6a-e and 13c, e with anthranilic acid was proved to give the corresponding triazino [3,2-b] quinazolindiones 9a-e and the 1-amino derivatives 11a, b.
authors: Chemistry Department, Faculty of Science, Cairo University, Giza.
authors: M M
authors: MM
authors: Eid
authors: R A
authors: RA
authors: Hassan
authors: A M
authors: AM
authors: Kadry
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D013056:Spectrophotometry, Ultraviolet; D014227:Triazines / Q000138:chemical synthesis*
chemical_list: D014227:Triazines