[A synthetic peptide from Helix aspersa raises arterial pressure in rats].
New FMRF-amide like peptide, pGlu-Asp-Pro-Phe-Leu-Arg-Phe-NH2, originally isolated from the ganglia of Helix aspersa, was synthetized. Intravenous injections of this peptide (40-300 micrograms/kg) produce rapid dose dependent increase in the blood pressure and heart rate of anaesthetised rats. Since alpha-adrenoreceptor blockade with prazosin eliminated pressor response, it is concluded that the increase in the arterial pressure is mediated by sympathetic activation.
Deĭgin
V I
VI
Pomogaĭbo
S V
SV
Zhukovskiĭ
S V
SV
Vinogradov
V A
VA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006372:Helix, Snails; D008297:Male; D009479:Neuropeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D009479:Neuropeptides; D010455:Peptides; C054497:pyroglutamyl-aspartyl-prolyl-phenylalanyl-leucyl-arginyl-phenylalaninamide; D011761:Pyrrolidonecarboxylic Acid
Sinteticheskiĭ peptid iz Helix aspersa povyshaet arterial'noe davlenie u krys.