title: The pharmacokinetics and tissue penetration of FCE 22101 following intravenous and oral administration.
abstract: One gram each of FCE 22101 and its acetoxymethyl ester (FCE 22891) were administered sequentially to six healthy volunteers. After intravenous administration Cmax was 167 mg/l, and the elimination half-life 0.8 h. Following oral administration Cmax was 6.9 mg/l and the elimination half-life 0.6 h. Penetration into inflammatory fluid was rapid, and the percentage penetration 86.1 and 60.9% following oral and intravenous dosing respectively. Urine recovery was greater after intravenous administration (31%) than after oral (11%).
authors: Department of Medical Microbiology, Dudley Road Hospital, Birmingham, UK.
authors: J M
authors: JM
authors: Webberley
authors: R
authors: R
authors: Wise
authors: J M
authors: JM
authors: Andrews
authors: J P
authors: JP
authors: Ashby
authors: D
authors: D
authors: Wallbridge
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D001768:Blister / Q000378:metabolism; D015780:Carbapenems; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007769:Lactams; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D007769:Lactams; C041561:FCE 22891; C040033:ritipenem