Hypertension in diabetic clinic patients and their siblings.
The prevalence of hypertension was investigated in a systematically chosen sample of patients attending a diabetic clinic. One hundred ninety-one patients were classified as Type 1 (insulin-dependent), 183 were classified as Type 2 (non-insulin-dependent) and 12 were deemed unclassifiable. Two hundred fifty-five control subjects attending non-medical out-patient clinics were also examined under similar conditions. Hypertension was significantly (p less than 0.001) more common among Type 2 patients (38%) than among Type 1 patients (15%) or control subjects (16%). The difference between Type 2 patients and control subjects, but not between Type 2 and Type 1 patients, persisted when the influences of age and body mass index were controlled. We also investigated the prevalence of hypertension among the siblings of the hypertensive patients identified, together with a matched normotensive group. One hundred eighty-eight siblings were examined and historical details were obtained for a further 451 siblings. When age and body mass index were controlled for in examined siblings, the risk of hypertension was greater in those with a hypertensive proband than in those with a normotensive proband, in the control (p less than 0.06) and Type 1 (p less than 0.02) groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Kelleher
C
C
Department of Medicine, Regional Hospital, Cork, Ireland.
Kingston
S M
SM
Barry
D G
DG
Cole
M M
MM
Ferriss
J B
JB
Grealy
G
G
Joyce
C
C
O'Sullivan
D J
DJ
D000328:Adult; D000368:Aged; D000375:Aging; D000419:Albuminuria / Q000652:urine; D000428:Alcohol Drinking; D001581:Benzothiadiazines; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D048909:Diabetes Complications; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism / Q000628:therapy; D004232:Diuretics; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012907:Smoking; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use; D011795:Surveys and Questionnaires
D001581:Benzothiadiazines; D001786:Blood Glucose; D004232:Diuretics; D006442:Glycated Hemoglobin; D049993:Sodium Chloride Symporter Inhibitors