title: Risk factors in lacunar syndromes: a case-control study.
abstract: The association between some hypothetical risk factors (previous TIA, hypertension, ECG ischemic abnormalities, diabetes, cigarette smoking, atrial fibrillation, hypercholesterolemia, hypertriglyceridemia, high hematocrit) and lacunar syndromes has been evaluated by a matched sample case-control study involving 108 consecutive, incident cases with lacunar syndrome and 216 hospital control subjects, matched for sex and age. A significant increase of Relative Risk (RR) has been shown for: 1. Previous history of TIA; 2. Hypertension; 3. Smoking; 4. Diabetes. No relevance was shown for: 1. Atrial fibrillation; 2. Hypercholesterolemia; 3. Hypertriglyceridemia; 4. High hematocrit. The analysis of the triplets of subjects (1 case + 2 controls) without hypertension showed a significant RR increase for: 1. Previous history of TIA; 2. Ischemic cardiac abnormalities; 3. Atrial fibrillation. Such findings support the hypothesis that, in a minority of cases with lacunar syndrome, the pathogenetic mechanism could be different from occlusion of penetrating arteries in hypertensive patients.
authors: Department of Neurology, University of Genoa, Italy.
authors: C
authors: C
authors: Gandolfo
authors: C
authors: C
authors: Caponnetto
authors: M
authors: M
authors: Del Sette
authors: D
authors: D
authors: Santoloci
authors: C
authors: C
authors: Loeb
mesh_terms: D000368:Aged; D002544:Cerebral Infarction / Q000209:etiology / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000503:physiopathology; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D002546:Ischemic Attack, Transient / Q000150:complications; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013577:Syndrome