Flordipine, a calcium channel blocker, which does not influence lipidemia or atherosclerosis in cholesterol-fed rabbits.
Data relating to the effects of calcium channel blockers on experimental atherosclerosis in rabbits are inconsistent with most studies finding no effect on either serum lipids or atherosclerosis. We have administered flordipine (5, 15 or 45 mg/kg/day) for 10 weeks to rabbits fed 1% cholesterol and 4% corn oil. At no level of treatment was there an effect on serum or liver lipids or on aortic sudanophilia.
Kritchevsky
D
D
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
Tepper
S A
SA
Klurfeld
D M
DM
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001161:Arteriosclerosis / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002791:Cholesterol, Dietary; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology*; D011817:Rabbits
D002121:Calcium Channel Blockers; D002791:Cholesterol, Dietary; D009539:Nicotinic Acids; C042357:flordipine