title: Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy.
abstract: Transection of the facial nerve leads to a glial response within its central nucleus of origin. Concomitant with a proliferation of satellite microglial cells an astrocytic reaction is also seen. In the present study light and electron microscopic autoradiography were performed in order to clarify whether only microglial cells undergo mitosis following facial nerve axotomy or if astrocytes also divide. Our results provide the first electron microscopical autoradiographic evidence for the labelling of endogenous microglial cells. We suggest that microglial cells are the only proliferating element during this process in the rat facial nucleus.
authors: Department of Neuromorphology, Max-Planck-Institute for Psychiatry, Munich, F.R.G.
authors: M B
authors: MB
authors: Graeber
authors: W
authors: W
authors: Tetzlaff
authors: W J
authors: WJ
authors: Streit
authors: G W
authors: GW
authors: Kreutzberg
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology* / Q000648:ultrastructure; D001345:Autoradiography; D005154:Facial Nerve / Q000502:physiology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008938:Mitosis; D009416:Nerve Regeneration; D009457:Neuroglia / Q000166:cytology* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine
chemical_list: D013936:Thymidine