Antioxidants to treat chronic pancreatitis in childhood? Case report and possible implications for pathogenesis.
The case history of a 10-yr old boy with calcific chronic pancreatitis is reported. His theophylline clearance of 450 ml/kg/h was several times higher than normal, indicating induction of cytochromes P450. Painful attacks disappeared concurrently with administration of antioxidants. The possible relevance of these findings is discussed in the context of chronic pancreatitis in childhood.
Braganza
J M
JM
Department of Gastroenterology, Royal Infirmary, Manchester, U.K.
Thomas
A
A
Robinson
A
A
D000975:Antioxidants / Q000627:therapeutic use*; D002648:Child; D002908:Chronic Disease; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004790:Enzyme Induction; D005609:Free Radicals; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000188:drug therapy* / Q000209:etiology
D000975:Antioxidants; D005609:Free Radicals; D003577:Cytochrome P-450 Enzyme System