[Crystal modifications of 3-cyan-6-methyl-5-(pyrid-4-yl)-1,2-dihydropyrid-2-one (milrinone)].
The preparation and characterisation of crystalline alpha-, beta- and gamma modifications of 3-cyan-6-methyl-5-(4-pyrid-4-yl)-1,2-dihydropyrid-2-on e are described. The thermic transformation of alpha- and beta-modification into gamma-modification was proved by thermogravimetric analysis (t.g.a.), differential scanning calorimetry (d.s.c.), IR and powder diffraction pattern. In dissolution behaviour no significant differences were found between the modifications.
Klauschenz
E
E
Akademie der Wissenschaften der DDR, Institut für Wirkstofforschung, Berlin.
Hagen
V
V
Gentsch
B
B
Niedrich
H
H
Dathe
M
M
Reck
G
G
Jänsch
H J
HJ
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D020105:Milrinone; D011728:Pyridones / Q000032:analysis*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D011728:Pyridones; D020105:Milrinone
Kristallmodifikationen von 3-Cyan-6-methyl-5-(pyrid-4-yl)-1,2-dihydropyrid-2-on (Milrinon).