Immunochemical similarity of the human plasma growth hormone-binding protein and the rabbit liver growth hormone receptor.
We probed the (immunochemical) relationship between the recently discovered growth hormone binding protein in human plasma and the growth hormone receptor using monoclonal and polyclonal antibodies raised against rabbit liver growth hormone receptor. The human binding protein was recognized by these antibodies; its immunological crossreactivity compared to the rabbit receptor was 1-2%. These data suggest a) that the binding protein and the receptor are structurally related and b) that rabbit and human growth hormone receptors share some but not all epitopes.
Baumann
G
G
Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611.
Shaw
M A
MA
D000818:Animals; D001666:Binding Sites, Antibody; D001667:Binding, Competitive; D002352:Carrier Proteins / Q000097:blood* / Q000276:immunology; D003429:Cross Reactions; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D011233:Precipitin Tests; D011817:Rabbits; D011986:Receptors, Somatotropin / Q000032:analysis* / Q000276:immunology
D002352:Carrier Proteins; D011986:Receptors, Somatotropin; D013006:Growth Hormone; C051815:somatotropin-binding protein