title: cis-Halovinylthioacetamido side chain, a new effective structural element for 7 beta-substitution in cephem and oxacephem antibiotics. II. 7 beta-cis-Fluorovinylthioacetamino-7 alpha-methoxy-1-oxacephems.
abstract: The synthesis and in vitro activity of 1-oxacephem derivatives having a substituted or a non-substituted cis-fluorovinylthioacetamido side chain at C-7 are described. Of these new 1-oxacephem antibiotics, 2355-S (42a) shows good antibacterial activity against Gram-positive and Gram-negative bacteria, and very favorable pharmacokinetic properties.
authors: Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
authors: Y
authors: Y
authors: Nishitani
authors: T
authors: T
authors: Aoki
authors: T
authors: T
authors: Konoike
authors: H
authors: H
authors: Takahashi
authors: S
authors: S
authors: Yamamoto
authors: Y
authors: Y
authors: Nishino
authors: M
authors: M
authors: Yoshioka
authors: T
authors: T
authors: Tsuji
authors: Y
authors: Y
authors: Komatsu
authors: S
authors: S
authors: Matsuura
mesh_terms: D008826:Microbial Sensitivity Tests; D009070:Moxalactam / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D009070:Moxalactam