title: Elastosis perforans serpiginosa: clinical, histomorphological and immunological studies.
abstract: In two cases of elastosis perforans serpiginosa (EPS) new clinical and laboratory data are described and discussed. In Case 1, EPS was triggered by penicillamine-D within an unusually short period (about one year). In Case 2, EPS was apparently primarily triggered by a vena puncture. In both cases the light and electron microscopic findings were strictly compatible with EPS. These findings are summarized. In the active lesions of both cases increased numbers of helper T-cells and Langerhans cells were shown, while cytotoxic-suppressor T-cells were nearly completely absent. Leu 3a+ cells and Leu 6+ cells were also present in the inactive central area of the lesions. The data presented may cast doubt on the relationship of immunological findings to pathogenetic events in the disease.
authors: Department of Dermatovenereology, Erasmus University, Rotterdam, The Netherlands.
authors: T
authors: T
authors: van Joost
authors: V D
authors: VD
authors: Vuzevski
authors: F J
authors: FJ
authors: ten Kate
authors: E
authors: E
authors: Stolz
authors: F
authors: F
authors: Heule
mesh_terms: D000328:Adult; D003240:Connective Tissue Diseases / Q000276:immunology / Q000473:pathology; D004549:Elastin / Q000096:biosynthesis / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D012871:Skin Diseases / Q000276:immunology / Q000473:pathology
chemical_list: D004549:Elastin