Effect of aspirin on haloperidol-induced cataleptic behavior in mice.
Haloperidol given intraperitoneally dose-dependently elicited cataleptic behavior, evaluated by high bar and four-cork tests, in mice. The haloperidol-induced cataleptic behavior was reduced dose-dependently after oral treatment with aspirin, a cyclooxygenase inhibitor. The intra-cerebroventricular administration of prostaglandin F2a produced cataleptic behavior of long duration determined by the high bar test. It is suggested that prostaglandins may participate in the induction of cataleptic behavior in part.
Ono
N
N
Department of Pharmacology, School of Pharmaceutical Sciences, Fukuoka University, Japan.
Saito
R
R
Abiru
T
T
Matsushita
Y
Y
Kamiya
H
H
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced* / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011453:Prostaglandins / Q000502:physiology
D011453:Prostaglandins; D006220:Haloperidol; D001241:Aspirin