[Effect of komplamin and nikoshpan on brain circulation and metabolism in the postischemic period].
Intravenous administration of komplamin to anesthetized cats before the brain ischemia or in the early period following ischemia prevents the development of the postischemic phenomenon of the cerebral blood flow nonrecovery and beneficially influences the cerebral metabolism: restores oxygen and glucose consumption by the brain, decreases pyruvic acid level in the arterial and venous blood, attenuates the phenomenon of acidosis. Nikoshpan improves the blood supply to the brain, restores oxygen and glucose consumption by the brain in the postischemic period only if administered before the brain ischemia.
Nagornaia
G V
GV
Gaevyĭ
M D
MD
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004338:Drug Combinations / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005260:Female; D006614:Hindlimb / Q000098:blood supply; D007511:Ischemia / Q000188:drug therapy / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009525:Niacin / Q000627:therapeutic use*; D009539:Nicotinic Acids / Q000627:therapeutic use*; D010208:Papaverine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013806:Theophylline / Q000031:analogs & derivatives*; D013997:Time Factors; D014665:Vasodilator Agents / Q000627:therapeutic use*; D014971:Xanthinol Niacinate / Q000627:therapeutic use*
D004338:Drug Combinations; D009539:Nicotinic Acids; D014665:Vasodilator Agents; D009525:Niacin; D014971:Xanthinol Niacinate; C005317:drotaverin; C055599:nicospan; D013806:Theophylline; D010208:Papaverine
Vliianie komplamina i nikoshpana na krovoobrashchenie i metabolizm golovnogo mozga v postishemicheskom periode.