title: Osmoregulation of thirst and vasopressin during normal menstrual cycle.
abstract: Changes in osmoregulation during normal menstrual cycle were examined in 15 healthy women. In 10 women, studied repetitively during two consecutive menstrual cycles, basal plasma osmolality, sodium, and urea decreased by 4 mosmol/kg, 2 meq/l, and 0.5 mM, respectively (all P less than 0.02) from the follicular to luteal phase. Plasma vasopressin, protein, hematocrit, mean arterial pressure, and body weight did not change. In five other women, diluting capacity and osmotic control of thirst and vasopressin release were assessed in follicular, ovulatory, and luteal phases. Responses of thirst and/or plasma vasopressin, urine osmolality, osmolal and free water clearance to water loading, and infusion of hypertonic saline were normal and similar in the three phases. However, the plasma osmolality at which plasma vasopressin and urine osmolality were maximally suppressed as well as calculated osmotic thresholds for thirst and vasopressin release were lower by 5 mosmol/kg in the luteal than in the follicular phase. This lowering of osmotic thresholds for thirst and vasopressin release, which occurs in the luteal phase, is qualitatively similar to that observed in pregnancy and should be taken into account when studying water balance and regulation of vasopressin secretion in healthy cycling women.
authors: Department of Medicine, University of Chicago, Pritzker School of Medicine, Illinois 60637.
authors: T J
authors: TJ
authors: Vokes
authors: N M
authors: NM
authors: Weiss
authors: J
authors: J
authors: Schreiber
authors: M B
authors: MB
authors: Gaskill
authors: G L
authors: GL
authors: Robertson
mesh_terms: D000328:Adult; D001794:Blood Pressure; D001798:Blood Proteins / Q000032:analysis; D001835:Body Weight; D004967:Estrogens / Q000097:blood; D005260:Female; D006400:Hematocrit; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle; D011374:Progesterone / Q000097:blood; D012016:Reference Values; D012964:Sodium / Q000097:blood; D013894:Thirst; D014508:Urea / Q000097:blood; D014667:Vasopressins / Q000097:blood*; D014882:Water-Electrolyte Balance
chemical_list: D001798:Blood Proteins; D004967:Estrogens; D014667:Vasopressins; D011374:Progesterone; D014508:Urea; D007986:Luteinizing Hormone; D012964:Sodium