Selective toxicity of gossypol against epithelial tumors and its detection by magnetic resonance spectroscopy.
The antitumor toxicity of gossypol was measured in 6 human carcinoma cell lines and compared with its toxicity against human bone marrow stem cells. Marrow cells were more resistant than any of the tumor cell lines, and tumor cell sensitivity depended on the content of intracellular LDH-M. [31P]-Magnetic resonance spectroscopy showed decline in tumor ATP levels occurring within 24 hours of treatment, suggesting that this non-invasive technique may serve as an early biochemical monitor of gossypol toxicity.
Benz
C
C
Cancer Research Institute, University of California, San Francisco.
Keniry
M
M
Goldberg
H
H
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D006072:Gossypol / Q000494:pharmacology*; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008113:Liver Neoplasms / Q000188:drug therapy; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009368:Neoplasm Transplantation; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D051381:Rats; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D006072:Gossypol