[Tetralogy of Fallot following coumarin administration in early pregnancy--an embryopathy?].
A case report of a 35-year old woman is presented who continued a coumarin therapy unconscious of an early pregnancy up to day 61. At term she delivered a baby with tetralogy of Fallot, up to now not mentioned in the symptom complex of malformations due to a coumarin therapy. In the case presented the typical symptoms of a warfarin embryopathy including a chondrodysplasia punctata and other morphological changes were lacking. Although some cases of cardiac malformations have been reported in literature following coumarin therapy in early pregnancy, a causal connection could not be confirmed.
Balde
M D
MD
Universitäts-Frauenklinik, Homburg, Saar.
Breitbach
G P
GP
Wettstein
A
A
Hoffmann
W
W
Bastert
G
G
D015110:4-Hydroxycoumarins / Q000009:adverse effects*; D000328:Adult; D004452:Echocardiography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010644:Phenprocoumon / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011261:Pregnancy Trimester, First; D013771:Tetralogy of Fallot / Q000139:chemically induced*; D013924:Thrombophlebitis / Q000188:drug therapy*
D015110:4-Hydroxycoumarins; D010644:Phenprocoumon
Fallotsche Tetralogie nach Cumarineinnahme in der Frühschwangerschaft--eine Embryopathie?