title: The use of long synthetic microvascular grafts to vascularise free flaps in rabbits.
abstract: A 5 cm length of 2 mm internal diameter (i.d.) synthetic, expanded polytetrafluoroethylene (PTFE, or Gore-Tex) vascular graft was used to connect 25 rabbit inferior epigastric flaps to the contralateral femoral vessels. In 15 animals an expanded PTFE graft connected the opposite femoral artery to the flap while the ipsilateral venous drainage remained intact. In the remaining 10 animals an expanded PTFE graft was used to replace the venous drainage of the flap and connected to the opposite femoral vein while the ipsilateral femoral artery supplied the flap. Flap survival and graft patency were evaluated over 3 weeks. Ten of 15 flaps with intra-arterial grafts survived at 3 weeks (67%). Only 27% (4/15) of their supplying grafts remained patent for 3 weeks, although 67% (10/15) were patent at 10 days. All 10 flaps, where expanded PTFE grafts replaced venous outflow, failed within 36 hours. At exploration these grafts were thrombosed or collapsed. In conclusion, currently available 2 mm (i.d.) expanded PTFE vascular graft cannot maintain patency in a low blood flow circulation supplying an isolated free flap.
authors: Microsurgery Research Centre, St Vincent's Hospital, Melbourne, Australia.
authors: T Y
authors: TY
authors: Shen
authors: G M
authors: GM
authors: Mitchell
authors: W A
authors: WA
authors: Morrison
authors: B M
authors: BM
authors: O'Brien
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis; D005263:Femoral Artery / Q000601:surgery; D005268:Femoral Vein / Q000601:surgery; D006083:Graft Occlusion, Vascular / Q000209:etiology; D006085:Graft Survival; D008866:Microsurgery / Q000379:methods; D011817:Rabbits; D013524:Surgical Flaps; D013662:Tea; D013997:Time Factors
chemical_list: D013662:Tea