[Animal pharmacokinetics in the quantitative estimation of clinical pharmacokinetics of antitumor agents].
Animal extrapolation of antitumor drug pharmacokinetics deals with either the determination of equations describing drug disposition or the determination of physiological parameters governing this distribution. Papers on this subjects show the need for numerous animal species to predict quantitative evolution curves and the lack of precision in the obtained results. Practical interest of such studies is limited since the pharmacokinetic parameters are systematically evaluated in man during phase I trials. On the contrary, analysis of the mechanism of drug distribution cannot be performed without interspecies scaling to evaluate physiological parameters which are not measurable in humans.
Hecquet
B
B
Laboratoire de pharmacodynamie clinique, Centre Oscar-Lambret, Lille, France.
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D002945:Cisplatin / Q000493:pharmacokinetics; D004285:Dogs; D004341:Drug Evaluation / Q000379:methods; D008657:Metabolic Clearance Rate; D008727:Methotrexate / Q000493:pharmacokinetics; D008954:Models, Biological; D011817:Rabbits; D051381:Rats
D000970:Antineoplastic Agents; D002945:Cisplatin; D008727:Methotrexate
La pharmacocinétique animale dans la prévision quantitative de la pharmacocinetique clinique des agents antitumoraux.