Repeated electroconvulsive shock normalizes blood glucose levels in genetically obese mice (C57BL/6J ob/ob) but not in genetically diabetic mice (C57BL/KsJ db/db).
There are several conflicting reports on the effect of electroconvulsive shock (ECS) on diabetes in humans. The present study investigated the effect of repeated ECS on blood glucose levels in genetically obese mice, which are considered an animal model for non-insulin dependent (maturity onset) diabetes. These mice were compared with genetically diabetic mice which are thought to be an animal model for insulin-dependent (juvenile-type) diabetes. A marked decrease in blood glucose concentrations was observed in obese mice after the first ECS which lasted for 14 days after the last ECS. No effect was seen in genetically diabetic mice. The neural mechanisms by which ECS normalizes blood glucose in genetically obese mice are discussed.
Nutt
D J
DJ
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892.
Gleiter
C H
CH
Linnoila
M
M
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001833:Body Temperature Regulation; D001835:Body Weight; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000235:genetics / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D004195:Disease Models, Animal; D004565:Electroconvulsive Therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese / Q000097:blood*; D013997:Time Factors
D001786:Blood Glucose