Delivery of albuterol aerosol by aerochamber to young children.
Inhalation of albuterol aerosol, 200 micrograms, delivered from metered dose inhalers via Aerochamber, elicited a highly significant improvement in peak expiratory flow rate from 70% to 84% and 91% predicted normal 5 and 20 minutes after treatment, respectively, in 30 asthmatic children 3 to 6 years of age. No significant increase in peak expiratory flow rate followed inhalation of placebo by a similar group of 16 asthmatic children. Use of the Aerochamber permits effective delivery of medication from metered dose inhalers to children as young as 3 years of age.
Sly
R M
RM
Department of Allergy and Immunology, Children's Hospital National Medical Center, Washington, DC.
Barbera
J M
JM
Middleton
H B
HB
Eby
D M
DM
D000280:Administration, Inhalation; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D010366:Peak Expiratory Flow Rate; D011674:Pulse; D014109:Total Lung Capacity
D000336:Aerosols; D000420:Albuterol