Effect of different Ca2+ entry blockers on dopamine-induced inhibition of in vitro prolactin secretion.
The organic Ca2+ entry blockers nimodipine, verapamil, flunarizine and diltiazem belong to different chemical classes but antagonized, at the concentrations of 1 and 10 microM, the inhibitory effect exerted by 1-10 microM dopamine on in vitro prolactin secretion from the pituitary gland. The results suggest a close functional interaction between Ca2+ entry blockers and the dopamine receptors involved in the inhibition of prolactin secretion.
Di Renzo
G
G
Department of Pharmacology, University of Naples, Italy.
Amoroso
S
S
Maida
P
P
Canzoniero
L
L
Nappi
C
C
Taglialatela
M
M
Annunzia
L
L
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004110:Diltiazem / Q000494:pharmacology; D018492:Dopamine Antagonists; D005444:Flunarizine / Q000494:pharmacology; D066298:In Vitro Techniques; D009553:Nimodipine / Q000494:pharmacology; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D009553:Nimodipine; D011388:Prolactin; D014700:Verapamil; D004110:Diltiazem; D005444:Flunarizine