Effects of lidocaine and procainamide on normal and abnormal intraventricular electrograms during sinus rhythm.
The effect of lidocaine (n = 6) and procainamide (n = 12) on electrogram characteristics from electrically normal right ventricular and electrically abnormal left ventricular endocardial sites was determined in 18 patients with prior myocardial infarction. Bipolar electrograms were recorded during sinus rhythm with No. 6F catheters positioned at a left ventricular abnormal site (electrograms fulfilling two of the following criteria: amplitude less than 3 mV, duration greater than 70 msec, or an amplitude to duration ratio less than .046) and normal sites at the right ventricular apex (RVA) and right ventricular outflow tract (RVOT). All electrograms were recorded from the same location before and after intravenous lidocaine or procainamide administered to obtain mean serum concentrations of 4.2 +/- 0.6 and 9.42 +/- 2 micrograms/ml respectively. Lidocaine and procainamide had no significant effect on sinus cycle length or electrogram amplitude. After lidocaine, no significant change in QRS width (112 +/- 23 vs 114 +/- 24 msec), left ventricular electrogram duration (76 +/- 21 vs 78 +/- 15 msec), or right ventricular electrogram duration (RVA 33 +/- 9 vs 33 +/- 10 msec, RVOT 31 +/- 9 vs 33 +/- 11 msec) was noted during sinus rhythm. At a paced cycle length of 600 msec, there was also no change in the paced QRS duration (197 vs 198 msec), the RVA electrogram duration (30 vs 32 msec), the RVOT electrogram duration (49 vs 52 msec), or the left ventricular electrogram duration (102 vs 108 msec).(ABSTRACT TRUNCATED AT 250 WORDS)
Schmitt
C G
CG
Clinical Electrophysiology Laboratory, Hospital of the University of Pennsylvania, Philadelphia.
Kadish
A H
AH
Marchlinski
F E
FE
Miller
J M
JM
Buxton
A E
AE
Josephson
M E
ME
D006328:Cardiac Catheterization / Q000379:methods; D003327:Coronary Disease / Q000503:physiopathology; D004562:Electrocardiography / Q000379:methods; D004566:Electrodes; D006339:Heart Rate / Q000187:drug effects*; D006352:Heart Ventricles / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*; D009203:Myocardial Infarction / Q000503:physiopathology; D011343:Procaine / Q000494:pharmacology*; D013610:Tachycardia / Q000503:physiopathology
D011343:Procaine; D008012:Lidocaine