Malignant acanthosis nigricans associated with non-Hodgkin's lymphoma. Report of 2 cases.
Two cases of malignant acanthosis nigricans associated with non-Hodgkin's lymphoma are presented. A 61-year-old negro male with a diffuse large cell non-Hodgkin's lymphoma presented extensive acanthosis nigricans, pachydermatoglyphy and florid cutaneous papillomatosis. No viral particles were observed by electron microscopic studies of the wart-like lesions. Acanthosis nigricans disappeared under chemotherapy. The second case was a 21-year-old caucasian male with non T non B diffuse large cell non-Hodgkin's lymphoma. Very few cases of acanthosis nigricans associated with non-Hodgkin's lymphoma have been reported in the literature, since to our knowledge these two are only the fourth and fifth. Pachydermatoglyphy and florid cutaneous papillomatosis are markers of malignant acanthosis nigricans.
Janier
M
M
Clinique des maladies cutanées et syphilitiques, Hôpital Saint-Louis, Paris, France.
Blanchet-Bardon
C
C
Bonvalet
D
D
Lenoble
M
M
Boiget
F
F
Civatte
J
J
D000052:Acanthosis Nigricans / Q000150:complications* / Q000473:pathology; D000328:Adult; D003878:Dermatoglyphics; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D010212:Papilloma / Q000150:complications / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology