title: Relation of coronary arterial patency and left ventricular function to electrocardiographic changes after streptokinase treatment during acute myocardial infarction.
abstract: One hundred and eighty-eight patients with evolving acute myocardial infarction were treated with intravenous streptokinase. Serial 12-lead electrocardiograms were recorded for 3 hours after treatment and inspected for rapid repolarization changes of the ST segment and T wave. Abrupt electrocardiographic repolarization changes were observed in 106 patients (56%) and were strongly predictive for an open infarct-related coronary artery at a mean of 6 days after treatment (predictive value = 0.92, sensitivity = 0.67). Abrupt electrocardiographic changes were not observed in 82 patients (44%). This absence was not a good predictor of an occluded infarct-related coronary artery (predictive value = 0.4). There was no relation between the presence or absence of abrupt electrocardiographic changes and global or regional left ventricular function after streptokinase treatment. Abrupt repolarization changes after thrombolytic treatment indicate a high probability of an open infarct-related artery. When abrupt repolarization changes do not occur, the patency of the infarct-related coronary artery cannot be predicted with accuracy. Serial electrocardiographic recordings do not provide sufficient information about coronary patency to eliminate the need for coronary arteriography.
authors: Cardiac Unit, Belfast City Hospital, Northern Ireland.
authors: S G
authors: SG
authors: Richardson
authors: P
authors: P
authors: Morton
authors: J G
authors: JG
authors: Murtagh
authors: M E
authors: ME
authors: Scott
authors: D B
authors: DB
authors: O'Keeffe
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels; D004562:Electrocardiography; D005069:Evaluation Studies as Topic; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007275:Injections, Intravenous; D009203:Myocardial Infarction / Q000188:drug therapy*; D011237:Predictive Value of Tests; D013300:Streptokinase / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013318:Stroke Volume / Q000187:drug effects; D013997:Time Factors; D014654:Vascular Patency / Q000187:drug effects*
chemical_list: D013300:Streptokinase