Synthesis of a phosphono analogue of cardiolipin and study of its silicic acid column chromatographic behaviour.
The synthesis is reported of the phosphono analogue of cardiolipin namely of 1,2-dipalmitoyloxypropyl-3-(2'-hydroxy propyl-3'-(1",2"-dipalmitoyl glycerol]biphosphonate. This was prepared by the condensation of 1,2-dipalmitoyl glycerol with 1,2-dipalmitoyl-oxypropyl-3-(2'-hydroxy propyl-3')-biphosphonate catalyzed by tri-isopropylbenzene sulfonyl chloride in pyridine. The final product was characterized by elemental analyses, phosphono phosphorus determinations, thin-layer chromatography and IR spectroscopy. The silicic acid column chromatographic behaviour of the phosphono analogue of cardiolipin was also studied.
Moschidis
M C
MC
Sancorin Laboratories, Athens, Greece.
D002308:Cardiolipins / Q000032:analysis / Q000138:chemical synthesis*; D002845:Chromatography; D004164:Diphosphonates / Q000138:chemical synthesis*
D002308:Cardiolipins; D004164:Diphosphonates; C055940:1,2-dipalmitoyloxypropyl-3-(2'-hydroxypropyl-3'-(1'',2''-dipalmitoylglycerol))biphosphonate