Angiotensin II specific receptors in subcommissural organ.
In the subcommissural organ of male rats, a circumventricular organ situated inside the blood-brain barrier, specific receptors for angiotensin II were demonstrated by binding studies on homogenated membranes and by autoradiography carried out on frozen sections using 125I-angiotensin II. The receptor sites were localized in the subnuclear region of cells of the subcommissural organ. A single class of binding sites was found whose capacity was modulated by changes in the sodium plasma concentration which led to variations in plasma volume.
Ghiani
P
P
Institute of Comparative Anatomy, University of Genova, Italy.
Uva
B
B
Vallarino
M
M
Mandich
A
A
Masini
M A
MA
D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D005665:Furosemide; D007700:Kinetics; D008297:Male; D009490:Neurosecretory Systems / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011945:Receptors, Angiotensin / Q000187:drug effects / Q000378:metabolism*; D012964:Sodium / Q000097:blood / Q000494:pharmacology; D013347:Subcellular Fractions / Q000378:metabolism; D013351:Subcommissural Organ / Q000378:metabolism*
D011945:Receptors, Angiotensin; D000804:Angiotensin II; D005665:Furosemide; D012964:Sodium