Relative bioavailability of the hydrochloride, sulphate and ethyl carbonate salts of quinine.
The hydrochloride, sulphate and ethylcarbonate salts of quinine were given in single oral doses (600 mg base equivalent) to nine healthy male subjects according to a cross-over design. No statistically significant differences were noted in the plasma drug concentration-time profiles although inter- and intra-subject variation in AUC, Cmax and tmax values was appreciable. The ethylcarbonate salt may be preferred for use in paediatric patients because of its neutral taste.
Jamaludin
A
A
National Drug Research Centre, Universiti Sains Malaysia, Penang.
Mohamad
M
M
Navaratnam
V
V
Selliah
K
K
Tan
S C
SC
Wernsdorfer
W H
WH
Yuen
K H
KH
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D006801:Humans; D006851:Hydrochloric Acid; D008297:Male; D011803:Quinine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012492:Salts; D013431:Sulfates
D012492:Salts; D013431:Sulfates; D011803:Quinine; D006851:Hydrochloric Acid