The use of endoscopic detrusor muscle biopsies for in vitro muscle strip studies.
A technique is described for performing in vitro muscle strip studies using samples of detrusor muscle taken by means of endoscopic biopsy forceps. This study of pig bladder muscle showed that the nerve mediated and drug induced responses of the muscle showed that the nerve mediated and drug induced responses of the muscle biopsies were similar to those produced by traditionally dissected muscle strips. The importance of continued access to human material for pharmacological studies is discussed.
Harrison
S C
SC
Department of Urology, Addenbrooke's Hospital, Cambridge.
Sibley
G N
GN
Doyle
P T
PT
Ferguson
D R
DR
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001706:Biopsy / Q000295:instrumentation / Q000379:methods; D004210:Dissection; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D019723:Endoscopes; D066298:In Vitro Techniques; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D013552:Swine; D001743:Urinary Bladder / Q000187:drug effects / Q000502:physiology*
D000109:Acetylcholine