Immunohistochemical localisation of nerve growth factor-like protein in the organ of Corti of the developing rat.
The presence of nerve growth factor (NGF)-like protein was investigated in the cochlea of the developing rat between birth and postnatal day 30, by the indirect immunofluorescence technique. Nerve growth factor-like protein could be detected from birth up to day 8. The immunostaining was localised within the hair mainly above their nuclei. No NGF-like immunoreactivity was observed in spiral ganglion cells. The data suggest that NGF acts as a neurotrophic factor, especially for efferent endings in the developing cochlea.
Despres
G
G
Université de Clermont II, Laboratoire de Neurobiologie, Ensemble Scientifique des Cezeaux, Aubière, France.
Giry
N
N
Romand
R
R
D000375:Aging / Q000378:metabolism*; D000818:Animals; D006198:Hair Cells, Auditory / Q000378:metabolism / Q000502:physiology*; D007150:Immunohistochemistry; D009414:Nerve Growth Factors / Q000378:metabolism / Q000502:physiology*; D009925:Organ of Corti / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D009414:Nerve Growth Factors