[Specific binding of a synthetic antioxidant from a series of spatially screened phenols, H3-phenozan, with isolated rat enterocytes].
Specific binding of gamma-(4 hydroxy-3,5-ditret. butyl-phenol) propionate (phenozan), a synthetic water-soluble screened phenol with antioxidant activity, with isolated rat enterocytes has been demonstrated. The Scatchard analysis of binding isotherms revealed two types of 3H-phenozan binding sites. It is concluded that the effect of synthetic screened phenol antioxidants on cellular activity is the result of two mechanisms of action--alteration of physicochemical properties of membrane lipids caused by the inhibitors of free-radical reactions and specific binding of these compounds to cell plasma membranes.
Khokhlov
A P
AP
Iarygin
K N
KN
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001665:Binding Sites; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D005609:Free Radicals; D007421:Intestine, Small / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D010666:Phenylpropionates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000975:Antioxidants; D005609:Free Radicals; D008563:Membrane Lipids; D010666:Phenylpropionates; C047854:fenozan
Spetsificheskoe sviazyvanie sinteticheskogo antioksidanta iz riada prostranstvenno zatrudnennykh fenolov 3H-fenozana s izolirovannymi énterotsitami krys.