Clinical relevance of food-specific IgG4 antibodies.
Although milk-specific IgG4 is frequently detectable in sera of apparently healthy individuals, the presence of alpha-casein (AC IgG4-specific) in high concentration (i.e. greater than 9.98 micrograms/ml) appears to be diagnostic of milk intolerance causing eczema in adults. The detection of egg-specific IgG4, on the other hand, has no similar diagnostic potential in egg-intolerant cases.
Shakib
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Midlands Asthma and Allergy Research Association, Derby, United Kingdom.
D000328:Adult; D000818:Animals; D001249:Asthma / Q000276:immunology; D002648:Child; D004485:Eczema / Q000276:immunology; D004527:Egg Proteins / Q000276:immunology; D005512:Food Hypersensitivity / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008892:Milk / Q000276:immunology
D004527:Egg Proteins; D007074:Immunoglobulin G