title: Free amino acids in rat ocular tissues during postnatal development.
abstract: Amino acid changes in the retina, vitreous, lens, iris-ciliary body and cornea of the rat eye were determined during postnatal growth. The amino acid concentrations of the ocular tissues showed varying profiles at various developmental stages. These results suggest a different timetable for development of each ocular tissue or indicate a synthesis of specific proteins in the postnatal period. Adult amino acid levels appeared to be fully reached on the 30th day after birth at the latest. Quantitatively the greatest changes were observed in taurine concentrations, which increased in all five ocular tissues during maturation. GABA changes paralleled those of taurine in the retina, whereas in the other ocular tissues GABA changes were very low. The greatest decrease in glutamic acid and aspartic acid concentration during postnatal development was in the lens, where these amino acids probably are needed for the synthesis of the lenticular proteins, the alpha-, beta-, and gamma-crystallines.
authors: Department of Biochemistry, University of Oulu, Finland.
authors: A A
authors: AA
authors: Heinämäki
authors: A S
authors: AS
authors: Lindfors
mesh_terms: D000375:Aging; D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D002924:Ciliary Body / Q000254:growth & development; D003315:Cornea / Q000254:growth & development; D005123:Eye / Q000254:growth & development*; D007498:Iris / Q000254:growth & development; D009928:Organ Specificity; D051381:Rats; D011916:Rats, Inbred F344; D012160:Retina / Q000254:growth & development; D014822:Vitreous Body / Q000254:growth & development
chemical_list: D000596:Amino Acids