[Pharmacokinetic characteristics of drugs in experimental splenectomy].
Pharmacokinetics of antipyrine, hexenal, phenylbutasone and caffeine was studied in experiments on splenectomized male rats. It was found that the half-life of all the drugs increased and plasma clearance decreased. Total protein binding assessed by using congo red decreased to a certain degree after splenectomy. The main factor modifying pharmacokinetics of drugs following splenectomy is believed to be depression of biotransformation processes in the liver.
Krakovskiĭ
M E
ME
Ashirmetov
A Kh
AKh
D000818:Animals; D000983:Antipyrine / Q000494:pharmacology*; D002110:Caffeine / Q000493:pharmacokinetics*; D006207:Half-Life; D006591:Hexobarbital / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D010653:Phenylbutazone / Q000493:pharmacokinetics*; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D013154:Spleen / Q000378:metabolism*; D013156:Splenectomy
D002110:Caffeine; D006591:Hexobarbital; D010653:Phenylbutazone; D000983:Antipyrine
Osobennosti farmakokinetiki nekotorykh lekarstvennykh veshchestv pri éksperimental'noĭ splenéktomii.