Corneal infection in mucosal scarring disorders and Sjögren's syndrome.
We reviewed 69 episodes of microbial keratitis occurring over an 11-year period in 56 patients with a mucosal scarring disorder or Sjögren's syndrome. Gram-positive bacterial isolates were the most common cause of infection, and accounted for almost all cases in patients with Sjögren's syndrome. Trichiasis (cicatricial pemphigoid), topical corticosteroids, bandage contact lenses, and corneal surgery were the main predisposing factors in the development of the corneal infection. In patients with ocular cicatricial pemphigoid, infection was much less common after chemotherapeutic control had been achieved. Recurrent infections were relatively frequent. There was a high rate of major complications, particularly in microbial keratitis complicating Sjögren's syndrome.
Ormerod
L D
LD
Cornea Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston.
Fong
L P
LP
Foster
C S
CS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy; D002648:Child; D002921:Cicatrix / Q000150:complications* / Q000473:pathology; D005128:Eye Diseases / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007634:Keratitis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D010390:Pemphigoid, Benign Mucous Membrane / Q000150:complications; D012008:Recurrence; D012859:Sjogren's Syndrome / Q000150:complications / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000150:complications
D000900:Anti-Bacterial Agents