title: [The quantitative identification of metabolites of dihydralazine in the human].
abstract: The metabolism of dihydralazine sulfate was studied in 11 hypertonic patients treated with that drug chronically. The metabolites were identified in urine with gc, dc, and hplc by comparison with synthesized reference compounds. Following metabolites could be verified: acetylated products, oxidation products, hydrazones and products of decomposition. Products resulting from reaction with nitrites could be not detected.
authors: Institut für Klinische Pharmakologie, Ernst-Moritz-Arndt-Universität Greifswald.
authors: T
authors: T
authors: Schneider
authors: W
authors: W
authors: Siegmund
authors: M
authors: M
authors: Zschiesche
authors: R
authors: R
authors: Kallwellis
authors: A
authors: A
authors: Scherber
mesh_terms: D000328:Adult; D000368:Aged; D001711:Biotransformation; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D004078:Dihydralazine / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged
chemical_list: D006830:Hydralazine; D004078:Dihydralazine
vernacular_title: Zum qualitativen Nachweis von Metaboliten des Dihydralazins beim Menschen.