[Effect of the sodium salt of galbanic acid on thrombocyte aggregation].
During in vitro experiments galbanic acid (a derivative of 7-hydroxycoumarin) at concentrations of 50, 100, 200 micrograms/ml suppressed the development of platelet aggregation induced by ADP, thrombin, histamine, adrenaline, acetylcholine and collagen. Intravenous administration of galbanic acid before bloodletting prevented and against the background of bloodletting eliminated platelet hyperaggregation in dogs.
Mansurov
M M
MM
Martirosov
M S
MS
D000818:Animals; D003374:Coumarins / Q000494:pharmacology* / Q000627:therapeutic use; D003864:Depression, Chemical; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006470:Hemorrhage / Q000097:blood / Q000188:drug therapy; D010974:Platelet Aggregation / Q000187:drug effects*; D013997:Time Factors
D003374:Coumarins; C048972:galbanic acid
Vliianie natrievoĭ soli gal'banovoĭ kisloty na agregatsiu trombotsitov.