[Effect of autologous blood irradiated in isolation on the restoration of leukopoiesis in an experimental model of prolonged leukopenia].
Reinfusion of irradiated (220 Gy) isolated blood (IIB) was shown to accelerate leukopoiesis restoration in conditions of myelodepression induced by the injection of cyclophosphane. Restoration of leucocyte count in the peripheral blood was preceded by the increase in DNA synthesis and bone marrow cellularity. Reinfusion of IIB also promoted a more rapid restoration of cellularity of lymphoid organs with cAMP predominating therein. The comparison of the processes under study in time permits to assume that the stimulatory effect of IIB is related to activation of proliferation and stimulation of cell maturing in bone marrow and lymphoid organs.
Moskalenko
I P
IP
Nikiforova
N A
NA
Martyniuk
N M
NM
Ishkhanova
M A
MA
Ronin
V S
VS
D000818:Animals; D001769:Blood / Q000528:radiation effects*; D001804:Blood Transfusion, Autologous; D003520:Cyclophosphamide / Q000633:toxicity; D006410:Hematopoiesis; D007962:Leukocytes; D007970:Leukopenia / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003520:Cyclophosphamide
Vliianie izolirovanno obluchennoĭ autokrovi na vosstanovlenie leĭkopoéza v éksperimental'noĭ modeli prolongirovannoĭ leĭkopenii.