In vitro activity of amdinocillin in combination with other beta-lactam antibiotics against aminoglycoside-susceptible and resistant gram-negative bacteria.
Amdinocillin alone and in combination with other beta-lactam antibiotics was tested for in vitro activity against aminoglycoside-susceptible and resistant gram-negative bacteria. Amdinocillin alone or in combination with ampicillin, ticarcillin, piperacillin, cefazolin, cefoxitin, and cefamandole had little to no activity against aminoglycoside-resistant E. coli, E. cloacae, K. pneumoniae, and S. marcescens. There was better activity with aminoglycoside-susceptible organisms, however, Overall, there was significantly more antagonism of amdinocillin combinations when tested with aminoglycoside-resistant organisms than with aminoglycoside-susceptible strains.
Nachamkin
I
I
University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104-4283.
Gibson
G
G
Sawyer
K
K
Samel
C
C
Skalina
D
D
D000560:Amdinocillin / Q000494:pharmacology*; D000617:Aminoglycosides; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002435:Cefamandole / Q000494:pharmacology; D002437:Cefazolin / Q000494:pharmacology; D002440:Cefoxitin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D010878:Piperacillin / Q000494:pharmacology; D013982:Ticarcillin / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002435:Cefamandole; D002440:Cefoxitin; D000667:Ampicillin; D013982:Ticarcillin; D002437:Cefazolin; D000560:Amdinocillin; D010878:Piperacillin