title: Intraoperative radiation therapy of hepatic metastases: technical aspects and report of a pilot study.
abstract: Surgical resection of hepatic metastases offers long-term survival, and possible cure, for selected patients with colorectal carcinoma. Fifty percent of patients considered candidates for resection are found to have disease confined to the liver. The resections necessary are often more extensive than predicted preoperatively, which provides an opportunity for innovative approaches using radiation therapy. The intraoperative radiation therapy technique presented here offers the ability to control multiple metastatic deposits in patients not deemed resectable. This is achieved using remote afterloading interstitial (Ir-192) radiation therapy to deliver tumoricidal radiation doses to limited volumes within the liver. The technique was used to treat 11 patients in a pilot study, delivering radiation doses of 20 Gy to the periphery of predetermined target volumes in a single treatment. The number of metastatic deposits treated ranged from 2 to 11 separate tumors with maximum diameters from 3 to 9 cm (median 6 cm). Hospitalizations were from 6 to 23 days (median 8) with only one patient experiencing a surgically related complication (wound dehiscence and pneumonia). There were no radiation related complications on follow-up to 18 months. Biopsies of two treated sites in a patient undergoing reoperation confirmed control of tumors by this procedure. This technique is offered as a standby procedure to patients undergoing exploration for hepatic resection at our institution.
authors: Georgetown University Hospital, Vincent T. Lombardi Comprehensive Cancer Research Center, Washington, D.C. 20007.
authors: A
authors: A
authors: Dritschilo
authors: K W
authors: KW
authors: Harter
authors: D
authors: D
authors: Thomas
authors: R
authors: R
authors: Nauta
authors: R
authors: R
authors: Holt
authors: T C
authors: TC
authors: Lee
authors: S
authors: S
authors: Rustgi
authors: J
authors: J
authors: Rodgers
mesh_terms: D000368:Aged; D003110:Colonic Neoplasms / Q000473:pathology; D006801:Humans; D007432:Intraoperative Period; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D008875:Middle Aged; D010865:Pilot Projects; D012004:Rectal Neoplasms / Q000473:pathology
chemical_list: D007496:Iridium Radioisotopes