title: Cerebrospinal fluid IgG and IgM indexes as indicators of active neurosyphilis.
abstract: Serological and non-serological tests were performed in matched samples of cerebrospinal fluid and serum from 236 syphilitic patients. An increased IgG or IgM index, or both, was found about 70 times more often in symptomatic neurosyphilis than in latent syphilis without involvement of the central nervous system. An increased Ig index, together with a cell count greater than 5/microL, was only found in symptomatic neurosyphilis. Although the numbers of data are small, we conclude that the IgG and IgM indexes are valuable tests in the diagnosis of syphilitic involvement of the central nervous system.
authors: Department of Clinical Chemistry, Academic Hospital, University of Amsterdam, The Netherlands.
authors: E A
authors: EA
authors: Hische
authors: J A
authors: JA
authors: Tutuarima
authors: E C
authors: EC
authors: Wolters
authors: L
authors: L
authors: van Trotsenburg
authors: R V
authors: RV
authors: van Eyk
authors: J D
authors: JD
authors: Bos
authors: A
authors: A
authors: Albert
authors: H J
authors: HJ
authors: van der Helm
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D009494:Neurosyphilis / Q000134:cerebrospinal fluid*
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M