Effect of taurine on calcium accumulation in resting and depolarised insect synaptosomes.
The effect of taurine (2-aminoethanesulphonic acid) on 45Ca2+ accumulation in resting and depolarised synaptosomes obtained from the locust Schistocerca americana gregaria was studied. Taurine reduced 45Ca2+ accumulation in resting synaptosomes, and this effect was more pronounced when synaptosomes were depolarised with either high [K+] or veratridine. Veratridine-induced 45Ca2+ accumulation was not affected by either gamma-aminobutyric acid or leucine, but was reduced by both verapamil and tetrodotoxin.
Whitton
P S
PS
Department of Biochemistry, University of Glasgow, Scotland.
Nicholson
R A
RA
Strang
R H
RH
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D006110:Grasshoppers / Q000378:metabolism*; D007930:Leucine / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D008854:Microscopy, Electron; D011188:Potassium / Q000494:pharmacology; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D013654:Taurine / Q000494:pharmacology*; D013779:Tetrodotoxin / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology; D014701:Veratridine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D002132:Calcium Radioisotopes; D013654:Taurine; D013779:Tetrodotoxin; D005680:gamma-Aminobutyric Acid; D014701:Veratridine; D014700:Verapamil; D007930:Leucine; D011188:Potassium; D002118:Calcium