title: [Hepatitis probably caused by Plethoryl. Apropos of 7 cases].
abstract: Seven patients developed acute hepatitis after receiving Plethoryl for obesity for 4 to 16 weeks. Jaundice was generally associated with or preceded by asthenia, nausea and pruritus. Serum aminotransferase activities were markedly increased whereas alkaline phosphatase and gamma-glutamyltransferase activities were moderately elevated. There was no hepatic failure. In all cases, Plethoryl administration was promptly discontinued. In 6 cases, jaundice disappeared within 2 to 4 weeks, and recovery occurred within 2 to 5 months. In one case, however, jaundice disappeared within 12 weeks and recovery took 10 months.
authors: Unité de Recherches de Physiopathologie Hépatique (INSERM U 24), Hôpital Beaujon, Clichy.
authors: D
authors: D
authors: Larrey
authors: E
authors: E
authors: Fréneaux
authors: G
authors: G
authors: Babany
authors: A
authors: A
authors: Berson
authors: O
authors: O
authors: Amédée-Manesme
authors: C
authors: C
authors: Degott
authors: L
authors: L
authors: Bettan
authors: B
authors: B
authors: Paugam
authors: D
authors: D
authors: Pessayre
authors: J P
authors: JP
authors: Benhamou
mesh_terms: D000208:Acute Disease; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003510:Cyclohexanes / Q000009:adverse effects*; D003512:Cyclohexanones / Q000009:adverse effects* / Q000378:metabolism; D004224:Diterpenes; D004338:Drug Combinations / Q000009:adverse effects / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008875:Middle Aged; D014284:Triiodothyronine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism; D014801:Vitamin A / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D003510:Cyclohexanes; D003512:Cyclohexanones; D004224:Diterpenes; D004338:Drug Combinations; D014284:Triiodothyronine; C044594:Plethoryl; D014801:Vitamin A
vernacular_title: Hépatites probablement dues au Pléthoryl. A propos de 7 observations.