The effect of food on the systemic availability of ketoprofen.
We have studied the pharmacokinetics of ketoprofen, a non-steroidal anti-inflammatory drug, in 12 patients after a single 100 mg oral dose both in fasting conditions and with a meal. Food significantly affected the peak plasma concentration of ketoprofen and decreased its absorption rate. However, the extent of absorption of ketoprofen, as reflected by the area under the plasma concentration time curve, appeared to be unchanged in the presence of food.
Bannwarth
B
B
Laboratoire de Pharmacologie, Faculté de Médecine de Nancy, Vandoeuvre les Nancy, France.
Lapicque
F
F
Netter
P
P
Monot
C
C
Tamisier
J N
JN
Thomas
P
P
Royer
R J
RJ
D000284:Administration, Oral; D000328:Adult; D004304:Dosage Forms; D005260:Female; D005502:Food; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D010666:Phenylpropionates / Q000493:pharmacokinetics*
D004304:Dosage Forms; D010666:Phenylpropionates; D007660:Ketoprofen