title: Relationships between polyamine, deoxyribonucleic acid and oestrogen receptor binding site concentrations in human breast tumours.
abstract: Concentrations of polyamines, DNA and oestrogen receptor (ER) binding sites have been estimated in 23 malignant and 2 benign breast tumours. Polyamine and DNA concentrations, expressed per unit wet weight of tissue, were significantly higher in ER-poor (less than 10 fmol/mg cytosol protein) than in ER-rich tumours. Spermidine/spermine ratios were similar in ER-poor and ER-rich tumours. There was a relationship between polyamine and DNA levels and when polyamine concentrations were expressed per unit weight of DNA those in ER-poor tumours did not differ from those in ER-rich tumours. Possible reasons for these findings are discussed.
authors: Department of Chemical Pathology, St Mary's Hospital Medical School, London, U.K.
authors: J C
authors: JC
authors: Norman
authors: J R
authors: JR
authors: Puddefoot
authors: E
authors: E
authors: Anderson
authors: H
authors: H
authors: Braunsberg
mesh_terms: D001943:Breast Neoplasms / Q000032:analysis*; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D011073:Polyamines / Q000032:analysis*; D011700:Putrescine / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis*; D013095:Spermidine / Q000032:analysis; D013096:Spermine / Q000032:analysis
chemical_list: D004273:DNA, Neoplasm; D011073:Polyamines; D011960:Receptors, Estrogen; D013096:Spermine; D013095:Spermidine; D011700:Putrescine