Determinations of IgG4 antibodies in treated hymenoptera sensitive patients.
Hymenoptera therapy with honeybee venoms has been practiced for the past ten years. A variety of studies have evaluated the short term effects of this therapy. This study focuses on the long term effects using venom specific IgE and IgG4 determinations. Results from the study indicate that after venom immunotherapy there is a rapid and prolonged rise in specific IgG4. This continues for several years, but after four or five years the specific IgG4 response seems to wane.
Gentlesk
M J
MJ
Division of Allergy and Clinical Immunology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.
Halpern
G M
GM
Scott
J R
JR
Rock
H S
HS
Harris
N S
NS
D000293:Adolescent; D000328:Adult; D000818:Animals; D001514:Bee Venoms / Q000627:therapeutic use; D002648:Child; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D006927:Hymenoptera / Q000276:immunology*; D007074:Immunoglobulin G / Q000378:metabolism*; D007299:Insect Bites and Stings / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D001514:Bee Venoms; D007074:Immunoglobulin G