[Biotransformation of 4-oxa-5-exo-(N-methylcarbamoyloxy)-tricyclo-[5.2.1.0-2, 6endo] dec-8-en-3one in the rat].
The metabolism of the analgesic compound 4-oxa-5-exo-(N-methylcarbamoyloxy)-tricyclo-[5.2.1.0-2. 6endo]dec-8-en-3one (Lu 253) was investigated after oral application in male Wistar rats. From urine, faeces, bile, and plasma epoxidized, rearranged, and N-desmethylated metabolites were isolated. The main reaction was the epoxidation of the double bond. The structure of most of the biotransformation products was proved by synthetic compounds.
Neidlein
R
R
Pharmazeutisch-Chemischen Institut, Universität Heidelberg.
Deigner
H P
HP
D000818:Animals; D001711:Biotransformation; D002219:Carbamates / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D005243:Feces / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002219:Carbamates; C055810:LU 253
Biotransformation von 4-Oxa-5-exo-(N-methylcarbamoyloxy)-tricyclo-[5.2.1.0-2,6endo]dec-8-en -3on an der Ratte.