title: [Hypergastrin and hyperprolactin syndrome caused by mucinous cystadenoma of the ovary].
abstract: We report a case of a clinically and biologically typical hypergastrinemia syndrome due to ovarian mucinous cystadenoma. When examined under histoimmunofluorescence, this "border-line" tumor was shown to contain a polymorphous endocrine cell proliferation, composed primarily of G cells and, to some degree, of D cells. Electron microscopic study further evidenced a small amount of prolactin containing cells, which coincided with elevated prolactin-levels in blood. Ovariectomy combined with vagotomy and pyloroplasty resulted in a prompt disappearance of both clinical and biological abnormalities. Ovarian mucinous cystadenomas have been known for a long time to contain endocrine cells, but only five cases, including the present one, have been described with fully developed endocrine expression. We suggest that this particular condition could be more frequent than generally admitted, and could justify systematic screening for mucinous cystadenoma in the case of peptide hormone dysfunction.
authors: Service d'Hépato-Gastroentérologie et de Médecine interne, Hôpital Louis-Mourier, Colombes.
authors: M
authors: M
authors: Garret
authors: J
authors: J
authors: Barge
authors: M F
authors: MF
authors: Lebodic
authors: J F
authors: JF
authors: Devars Du Mayne
authors: G
authors: G
authors: Molas
authors: M
authors: M
authors: Cerf
mesh_terms: D000328:Adult; D003537:Cystadenoma / Q000097:blood / Q000150:complications* / Q000473:pathology; D005260:Female; D005755:Gastrins / Q000097:blood*; D006801:Humans; D006966:Hyperprolactinemia / Q000209:etiology*; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology; D013577:Syndrome
chemical_list: D005755:Gastrins
vernacular_title: Syndrome d'hypergastrinie et d'hyperprolactinie dû à un cystadénome mucineux de l'ovaire.