title: Late results in patients with tetralogy of Fallot repaired during infancy.
abstract: Between 1973 and 1985, 220 infants (age 1 day to 18 months, mean = 7 months) underwent repair of tetralogy of Fallot (TOF) or TOF/pulmonary atresia with 17 early deaths. Follow-up status was ascertained for 184 of 203 survivors (91%) at a postoperative interval of 2 to 185 months (mean = 60 months). Significant residual hemodynamic lesions included ventricular septal defect in three, and right ventricular outflow gradient in excess of 40 mm Hg in 24. Reoperation or interventional catheter procedures were performed in 31 of 184 (17%) patients. All postoperative electrocardiograms were reviewed; only two of 184 patients had ventricular ectopy on any tracing. Holter data from 41 patients revealed one with sinus node dysfunction, 12 with Lown grade 1 ectopy, and one with Lown grade 2 or greater. Conduction defects, evaluated by electrocardiographic and electrophysiologic measurements, were not different from those reported for TOF patients undergoing repair at later ages. No study patient received antiarrhythmic medication, although one required a pacemaker for sinus node dysfunction. There were three late deaths, all unrelated to arrhythmia. TOF repair in infancy appears to be associated with an acceptable hemodynamic outcome, and a low incidence of ventricular ectopy and sudden death at 5 year follow-up.
authors: Department of Cardiology, Children's Hospital, Boston, MA 02115.
authors: E P
authors: EP
authors: Walsh
authors: S
authors: S
authors: Rockenmacher
authors: J F
authors: JF
authors: Keane
authors: T J
authors: TJ
authors: Hougen
authors: J E
authors: JE
authors: Lock
authors: A R
authors: AR
authors: Castaneda
mesh_terms: D001145:Arrhythmias, Cardiac / Q000453:epidemiology; D006328:Cardiac Catheterization; D004562:Electrocardiography; D005500:Follow-Up Studies; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D008991:Monitoring, Physiologic; D011183:Postoperative Complications / Q000453:epidemiology; D011184:Postoperative Period; D013902:Radiography, Thoracic; D012086:Reoperation; D013771:Tetralogy of Fallot / Q000401:mortality / Q000503:physiopathology* / Q000601:surgery