Assessment of two tests for the diagnosis of canine hyperadrenocorticism.
The low-dose dexamethasone suppression test and the urinary corticoid/creatinine ratio were assessed in 166 and 150 dogs, respectively, for their value in the diagnosis of hyperadrenocorticism. The diagnostic accuracy of the low-dose dexamethasone suppression test was 0.83, with a 95 per cent confidence interval from 0.76 to 0.88. The urinary corticoid/creatinine ratio had a diagnostic accuracy of 0.91 with a 95 per cent confidence interval from 0.85 to 0.95. The high predictive value of a negative corticoid/creatinine ratio (0.98; confidence interval 0.80 to 1.00) and the low cost of this test makes it preferable for screening purposes to the low-dose dexamethasone suppression test for which the predictive value of a negative test was calculated as 0.5g (confidence interval 0.43 to 0.73).
Rijnberk
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Small Animal Clinic, Faculty of Veterinary Medicine, State University of Utrecht, The Netherlands.
van Wees
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Mol
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JA
D000818:Animals; D003365:Costs and Cost Analysis; D003404:Creatinine / Q000652:urine*; D003480:Cushing Syndrome / Q000175:diagnosis / Q000662:veterinary*; D003907:Dexamethasone; D004283:Dog Diseases / Q000175:diagnosis*; D004285:Dogs; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006854:Hydrocortisone / Q000097:blood / Q000652:urine*; D008297:Male; D011237:Predictive Value of Tests
D003907:Dexamethasone; D003404:Creatinine; D006854:Hydrocortisone