Magnetic resonance, pathology and physiology of the BA1112 rhabdomyosarcoma in vivo.
We studied histology, findings on H-1 magnetic resonance (MR) imaging, and correlations of P-31 MR spectroscopy with microelectrode pH and pO2 measurements in the BA1112 rhabdomyosarcoma in WAG/Rij/Y rats. Intratumoral hemorrhage was a prominent feature on MR images and pathologic specimens. Eosinophilic necrosis could be seen microscopically but was not discernible on images. The peaks seen on P-31 MR spectra were similar to those reported in other tumors. The intratumoral pH was neutral despite low pO2 values and P-31 MR evidence for impaired metabolic status.
Sostman
D
D
Department of Diagnostic Radiology, Yale University School of Medicine.
Rockwell
S
S
Smith
G J
GJ
Gore
J C
JC
Kennedy
K A
KA
Habib
A
A
Fischer
J J
JJ
Armitage
I M
IM
Holcomb
W
W
D000818:Animals; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009368:Neoplasm Transplantation; D010100:Oxygen / Q000502:physiology; D010313:Partial Pressure; D051381:Rats; D012208:Rhabdomyosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology
D010100:Oxygen