A study of cerebellar cortical involvement in motor learning using a new avoidance conditioning paradigm involving limb movement.
These experiments were performed to examine the relationship between the simple and complex spike responses of 3-5 simultaneously recorded Purkinje cells during the acquisition, performance and extinction of a conditioned forelimb movement in decerebrate, unanesthetized ferrets. The data demonstrate parallel, correlated changes in simple and complex spike responses throughout the experimental period. Since the evaluated Purkinje cells were examined in the cerebellar cortical region that contains neurons highly modulated by the intermittent application of the conditioning stimulus, these findings argue against an induction of a long-lasting modification in simple spike responses by the climbing fiber input as the basis for this type of motor learning.
Lou
J S
JS
Division of Neurobiology, Barrow Neurological Institute, Phoenix, AZ 85013.
Bloedel
J R
JR
D000818:Animals; D001362:Avoidance Learning; D002525:Cerebellar Cortex / Q000502:physiology*; D005121:Extremities; D005289:Ferrets; D005684:Gait; D007858:Learning; D009043:Motor Activity; D009068:Movement