Treatment-independent pregnancies after cessation of gonadotropin ovulation induction in women with oligomenorrhea and anovulatory menses.
Life-table analysis was performed for the cumulative spontaneous pregnancy rate (CSPR) of 56 patients with oligomenorrhea and anovulatory cycles who had been treated with gonadotropin for ovulation induction between 1963 and 1985. Twenty-seven had at least one spontaneous pregnancy, giving rise to a CSPR of 66.4% (95% confidence limit [CL] 42.4% to 90.4%) at 115 months for the first spontaneous pregnancy, which is significantly lower than the cumulative induced pregnancy rate (CIPR) of 88.6% at 23 months for the first course of gonadotropin therapy (P less than 0.0001). This fertility potential was not affected by the baseline estrogen and follicle-stimulating hormone levels, diagnosis, result of gonadotropin therapy, and age and menstrual pattern during exposure to spontaneous pregnancy by Cox regression analysis. More multiple births occurred in the induced pregnancies than in the spontaneous pregnancies (P = 0.005).
Lam
S Y
SY
Department of Obstetrics & Gynaecology, University of Melbourne, Parkville, Victoria, Australia.
Baker
G
G
Pepperell
R
R
Evans
J H
JH
D000858:Anovulation / Q000503:physiopathology*; D005260:Female; D006065:Gonadotropins, Pituitary / Q000494:pharmacology*; D006801:Humans; D008599:Menstruation Disturbances / Q000503:physiopathology*; D009839:Oligomenorrhea / Q000503:physiopathology*; D010060:Ovulation / Q000187:drug effects*; D010062:Ovulation Induction; D011247:Pregnancy / Q000187:drug effects
D006065:Gonadotropins, Pituitary