title: Chromal focus of acquired chromatic discrimination loss and solvent exposure among printshop workers.
abstract: Acquired dyschromatopsia has been associated with exposure to organic solvents. However, the chromal focus of the loss may be indicative of its gravity. According to Kollner's rule, blue-yellow loss reflects changes in external retinal layers, while red-green loss appears to be indicative of internal retinal or optic nerve damage. The objective of the present study was to examine chromatic discrimination capacity of 30 printshop workers exposed to organic solvent mixtures, and of a non-exposed reference group. Colour vision was assessed with a colour arrangement test designed to detect acquired dyschromatopsia, the Lanthony D-15 desaturated panel. Quantitative analysis, using Bowman's colour confusion index, revealed significantly higher scores indicative of colour vision loss among the exposed workers as compared to the non-exposed. Analysis of covariance, with age as co-variate, showed colour confusion index to be significantly associated with job category. Similarly, qualitative analysis showed that the exposed workers presented a significantly higher prevalence of acquired dyschromatopsia as compared to the non-exposed group. However, analysis of the type of chromatic discrimination loss showed that among the nonexposed persons, dyschromatopsia was localized only in the blue-yellow range, while for 35% of the dyschromatopic-exposed persons, red-green loss as well as blue-yellow loss were present. Three-dimensional chi 2-analysis showed that the complex pattern of dyschromatopsia was not related to age, but to job category. These findings suggest that the type of dyschromatopsia, reflecting the gravity of neural alterations, may be a function of exposure level and/or the ophthalmotoxic properties of the particular solvents used.
authors: Département des sciences biologiques, Université du Québec à Montréal, Canada.
authors: D
authors: D
authors: Mergler
authors: S
authors: S
authors: Bélanger
authors: S
authors: S
authors: De Grosbois
authors: N
authors: N
authors: Vachon
mesh_terms: D000328:Adult; D003118:Color Perception / Q000187:drug effects*; D004781:Environmental Exposure; D006801:Humans; D008875:Middle Aged; D011327:Printing; D012997:Solvents / Q000009:adverse effects*
chemical_list: D012997:Solvents