title: Hydroxylation and oxidation of nalidixic acid in the turtle Pseudemys scripta elegans.
abstract: The turtle Pseudemys scripta elegans hydroxylates nalidixic acid into 7-hydroxynalidixic acid; this latter metabolite is oxidised into 7-carboxynalidixic acid. The elimination half-life of nalidixic acid in the turtle is 30 h. No glucuronides of nalidixic- and 7-hydroxynalidixic acid are formed, as they are in man.
authors: Department of Clinical Pharmacy, Sint Radboud Hospital, University of Nijmegen, The Netherlands.
authors: T B
authors: TB
authors: Vree
authors: J B
authors: JB
authors: Vree
authors: A M
authors: AM
authors: Baars
authors: J F
authors: JF
authors: Nouws
authors: Y A
authors: YA
authors: Hekster
mesh_terms: D000818:Animals; D006900:Hydroxylation; D009268:Nalidixic Acid / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000378:metabolism*; D010084:Oxidation-Reduction; D014426:Turtles / Q000378:metabolism*
chemical_list: C012368:7-hydroxynalidixic acid; D009268:Nalidixic Acid