[Effect of acute and chronic administration of melatonin on the temporal dynamics of apomorphine-induced stereotypy].
Melatonin (1-20 mg/kg) weakened in a dose-dependent way the intensity degree of apomorphine-induced stereotypy in rats. According to the spectral analysis data, this is followed by an increase of the number of waves with a short (2-3 per min) period in the temporal structure of stereotypy recorded every one minute. After administration of melatonin (1 mg/kg), the effect of apomorphine changed more in the afternoon (1-3 p.m.) than in the morning (6-8 a.m.) or the evening (6-8 p.m.) hours. The action of the hormone was of the adaptive character and was determined by the initial intensity of stereotypy. At chronic administration of melatonin (1 mg/kg), irrespective of the time of the day, there was a significant attenuation of apomorphine effect.
Arushanian
E B
EB
Ovanesov
K B
KB
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D008297:Male; D008550:Melatonin / Q000008:administration & dosage*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D008550:Melatonin; D001058:Apomorphine
Vliianie ostrogo i khronicheskogo vvedeniia melatonina na vremennúiu dinamiku apomorfinovoĭ stereotipii.