title: Phenylalanine metabolites as indicators of dietary compliance in children with phenylketonuria.
abstract: The data from this study showed that the excretion of three major metabolites of phenylalanine in patients with PKU approach normal values at blood phenylalanine levels less than 5.0 mg/dl. The MANOVA showed statistically significant differences in phenyllactate excretion when blood phenylalanine was greater than 10.0 mg/dl. The PL and total metabolite excretion were significantly correlated to blood phenylalanine in multiple samples taken from two individual subjects. Using data obtained from single patient observations may serve as a means for individualizing the PKU diet to insure low levels of phenylalanine metabolites and thus insure optimal development for patients with PKU.
authors: Department of Nutrition, University of Illinois, Chicago 60612.
authors: K
authors: K
authors: Michals
authors: M
authors: M
authors: Lopus
authors: R
authors: R
authors: Matalon
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008991:Monitoring, Physiologic; D010349:Patient Compliance; D010649:Phenylalanine / Q000097:blood / Q000378:metabolism* / Q000652:urine; D010661:Phenylketonurias / Q000178:diet therapy* / Q000378:metabolism
chemical_list: D010649:Phenylalanine