Reye-like syndrome following treatment with the pantothenic acid antagonist, calcium hopantenate.
Three senile patients developed fatal acute encephalopathy while receiving calcium hopantenate. The clinical, biochemical, and pathological picture was similar to Reye's syndrome. Calcium hopantenate is a pantothenic acid antagonist. The serum levels of calcium hopantenate were high in coma, and that of pantothenic acid examined in one patient was lowered. Evidence obtained indicated that the Reye-like syndrome might be caused by calcium hopantenate possibly due to the induction of pantothenic acid deficiency.
Noda
S
S
Department of Neurology, Kyushukoseinenkin Hospital, Kitakyushu, Japan.
Umezaki
H
H
Yamamoto
K
K
Araki
T
T
Murakami
T
T
Ishii
N
N
D000368:Aged; D001706:Biopsy; D003704:Dementia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008854:Microscopy, Electron; D010205:Pantothenic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D012202:Reye Syndrome / Q000139:chemically induced* / Q000473:pathology; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid