title: Effect of L-carnitine derivatives on heart mitochondrial damage induced by lipid peroxidation.
abstract: We have incubated heart mitochondria with ferrous ions as catalyst of lipid peroxidation. Ferrous ions induced an increase of malondialdehyde formation and a reduction of mitochondrial oxygen consuming and calcium transporting capacities. L-Carnitine and Acetyl-L-Carnitine failed to prevent mitochondrial damage. Propionyl-L-Carnitine significantly improved mitochondrial function, but failed to reduce malondialdehyde formation. This protective effect was specific for Propionyl-L-Carnitine as propionic acid and L-Carnitine did not modify mitochondrial damage.
authors: University of Brescia, Cattedra di Cardiologia, Italy.
authors: R
authors: R
authors: Ferrari
authors: G
authors: G
authors: Ciampalini
authors: G
authors: G
authors: Agnoletti
authors: A
authors: A
authors: Cargnoni
authors: C
authors: C
authors: Ceconi
authors: O
authors: O
authors: Visioli
mesh_terms: D000108:Acetylcarnitine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000493:pharmacokinetics; D002331:Carnitine / Q000494:pharmacology*; D005296:Ferrous Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000009:adverse effects* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D011817:Rabbits
chemical_list: D005296:Ferrous Compounds; D008054:Lipid Peroxides; C020748:ferrous sulfate; D008315:Malondialdehyde; D000108:Acetylcarnitine; D002331:Carnitine; D002118:Calcium