Involvement of glucose catabolism in avermectin production by Streptomyces avermitilis.
The addition of glucose in the early stage of fermentation suppressed not only avermectin production but also the activity of 6-phosphogluconate dehydrogenase in the pentose phosphate pathway. On the other hand, when glucose was added at the late stage of fermentation, suppression of avermectin formation and 6-phosphogluconate dehydrogenase activity was not observed but avermectin formation was increased and about a twofold-higher content of avermectins than that of the control fermentation was accumulated.
Ikeda
H
H
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Kotaki
H
H
Tanaka
H
H
Omura
S
S
D000871:Anthelmintics / Q000378:metabolism*; D003470:Culture Media; D005285:Fermentation; D005947:Glucose / Q000378:metabolism*; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000096:biosynthesis; D010427:Pentose Phosphate Pathway; D010734:Phosphogluconate Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D013302:Streptomyces / Q000201:enzymology / Q000378:metabolism*
D000871:Anthelmintics; D003470:Culture Media; D007559:Ivermectin; C019264:avermectin; D010734:Phosphogluconate Dehydrogenase; D005947:Glucose