Tissue levels of vitamin E (alpha-tocopherol) in response to continuous intravenous multivitamin infusion.
Weanling rats were made vitamin E deficient over a 10-week course. Vitamin E was then provided at 4 IU/kg/day as a continuous infusion of the alpha-tocopherol in Berocca PN. Tissue samples of heart, lung, liver, and perinephric fat and plasma were analyzed for vitamin E levels at 24 and 72 hr. Compared to experimental controls that received a rat chow containing 372 IU/g mixed tocopherol, normal levels were achieved in the test group within 24 hr in plasma and liver. Lung and heart muscle levels were within the normal range by 24-72 hr, although significantly below the control level; fat levels did not normalize. Continuous infusion of vitamin E as tocopherol in a multivitamin preparation results in normal tissue levels in lung and liver in a fashion similar to that achieved by previously described methods of single bolus intravenous infusion or repeated subcutaneous injection.
Gutcher
G R
GR
Department of Pediatrics, University of Wisconsin School of Medicine, Madison.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D007262:Infusions, Intravenous; D008099:Liver / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014810:Vitamin E / Q000378:metabolism*; D014811:Vitamin E Deficiency / Q000378:metabolism; D014815:Vitamins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014886:Weaning
D014815:Vitamins; D014810:Vitamin E