Malignant pleural effusion treated by tetracycline sclerotherapy. A comparison of single vs repeated instillation.
Fifty patients with malignant pleural effusion were randomized to receive one or two doses of tetracycline sclerotherapy. We found that a single sclerotherapy treatment with tetracycline at a dose of 20 mg/kg was as effective as two sclerotherapy treatments and provided symptomatic relief in 46 of the 50 patients.
Landvater
L
L
Division of Cardiothoracic Surgery, George Washington University Medical Center, Washington, DC.
Hix
W R
WR
Mills
M
M
Siegel
R S
RS
Aaron
B L
BL
D006801:Humans; D007322:Instillation, Drug; D009369:Neoplasms / Q000150:complications; D010996:Pleural Effusion / Q000209:etiology / Q000628:therapy*; D012597:Sclerosing Solutions / Q000008:administration & dosage*; D013752:Tetracycline / Q000008:administration & dosage*
D012597:Sclerosing Solutions; D013752:Tetracycline