[Angiotensin-converting enzyme inhibitors in angina pectoris].
In ten patients with angiographically demonstrated coronary heart disease exercise electrocardiograms were recorded before as well as two and four hours after administration of 5 or 10 mg Quinapril, an angiotensin converting enzyme inhibitor (ACEI). This reduced the sum of ST-segment depressions from 16.3 to 11.6 mV (P less than 0.001). While the heart rate remained unchanged, blood pressure fell from 147/91 to 119/79 mm Hg and the angina-free exercise time was clearly prolonged. Altogether there was a reduction of the ischaemia reaction by 35%. This perhaps speaks for an anti-anginal effect of ACEI, which could be of importance in the management of both hypertension and heart failure. In addition, the ACE inhibitors might be used as anti-angina drugs.
Bussmann
W D
WD
Abteilung für Kardiologie, Klinikum der Universität Frankfurt/Main.
Goerke
S
S
Schneider
W
W
Kaltenbach
M
M
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005080:Exercise Test; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D000077583:Quinapril; D044005:Tetrahydroisoquinolines
D000806:Angiotensin-Converting Enzyme Inhibitors; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D000077583:Quinapril
Angiotensin-Converting-Enzym-Hemmer bei Angina pectoris.