Evidence for linkage of IgA deficiency with the major histocompatibility complex.
A 57-year-old woman with IgA deficiency and Still's disease was the proband in a 20-member, three-generation kindred in which we studied the possible linkage of IgA deficiency with her HLA-A1-B8 haplotype. The presence of paternal A1-B8 haplotype complicated the analysis. Known maternal HLA-A1-B8 haplotype, present in three of the children of the proband, was associated with IgA deficiency, whereas all five family members with exclusively paternal A1-B8 had normal IgA. Of three third-generation family members whose A1-B8 haplotype was of indeterminate origin--that is, potentially either maternally or paternally derived--two had IgA deficiency and one did not.
Lakhanpal
S
S
Division of Rheumatology and Internal Medicine, Mayo Clinic, Rochester, MN 55905.
O'Duffy
J D
JD
Homburger
H A
HA
Moore
S B
SB
D000328:Adult; D002648:Child; D002675:Child, Preschool; D004406:Dysgammaglobulinemia / Q000235:genetics*; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D017098:IgA Deficiency; D008285:Major Histocompatibility Complex; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D006680:HLA Antigens