title: Increased sulfate uptake in skin fibroblasts isolated from cystic fibrosis patients.
abstract: Sulfate uptake into skin fibroblasts from patients with cystic fibrosis is increased. Sulfate transport studies were carried out in skin fibroblasts isolated from age/sex matched cystic fibrosis and normal subjects. Sulfate transport occurred mainly via a carrier-mediated proton-stimulated S04(2)-/Cl-exchange. The capacity (Vmax) of the uptake system operating at physiological concentrations of sulfate was stimulated in cystic fibrosis, but the affinity of the carrier for sulfate was not altered.
authors: Department of Pharmacology, University of Alabama, Birmingham Medical School 35294.
authors: A
authors: A
authors: Elgavish
authors: E
authors: E
authors: Meezan
mesh_terms: D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000494:pharmacology; D001639:Bicarbonates / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D002478:Cells, Cultured; D002712:Chlorides / Q000494:pharmacology; D003550:Cystic Fibrosis / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D012016:Reference Values; D012867:Skin / Q000378:metabolism*; D013431:Sulfates / Q000378:metabolism*
chemical_list: D001639:Bicarbonates; D002712:Chlorides; D013431:Sulfates; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid