Significance of maternal and infant serum antibodies to hepatitis B core antigen in hepatitis B virus infection of infancy.
The significance of IgM and IgG class antibodies to hepatitis B virus (HBV) core component (anti-HBc) was investigated in a study of maternal-fetal HBV transmission. An IgM anti-HBc response was lacking in the majority (49/53) of HBV-infected infants. This antibody thus cannot be used as an indicator of transplacental infection. However, most infants who became HBsAg positive during the first 6 months of life acquire infection in the perinatal period rather than transplacentally. Passively transferred maternal IgG anti-HBc in the infant and additional IgM anti-HBc positively in the carrier mother have no modulating influence on HBV infection of infants born to HBV carrier women.
Panda
S K
SK
Department of Pathology, All-India Institute of Medical Sciences, New Delhi.
Bhan
M K
MK
Guha
D K
DK
Gupta
A
A
Datta
R
R
Zuckerman
A J
AJ
Nayak
N C
NC
D000367:Age Factors; D002353:Carrier State / Q000276:immunology / Q000635:transmission; D005260:Female; D006509:Hepatitis B / Q000151:congenital / Q000276:immunology / Q000635:transmission*; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006512:Hepatitis B Core Antigens / Q000276:immunology*; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M