[Evaluation of the pharmacokinetics of ceftriaxone in neonates].
A pharmacokinetic study on ceftriaxone (CTRX) was conducted and the results obtained are summarized as follows. 1. CTRX was given in a dose of 20 micrograms/kg by intravenous bolus injection to 13 neonates, and satisfactory blood concentrations of the drug were achieved. However, since even a once daily administration revealed trough values of 10-20 micrograms/ml, CTRX may accumulate if administered to neonates of low weight. 2. The rate of CTRX transfer to cerebrospinal fluid was 5.7% in a neonate given a dose of 20 mg/kg by intravenous bolus injection. 3. The urinary recovery rate was 8.4% up to 12 hours in a neonate given a dose of 20 mg/kg by intravenous bolus injection.
Sunakawa
K
K
Department of Pediatrics, Second Tokyo National Hospital.
Sato
Y
Y
D001424:Bacterial Infections / Q000188:drug therapy* / Q000378:metabolism; D002443:Ceftriaxone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D007275:Injections, Intravenous; D008297:Male
D002443:Ceftriaxone