Autoimmunity and its therapy: mathematical modelling.
A mathematical description of autotolerance and autoimmunity based on the previous model of immune response for normal antigen stimulation is given. In particular, the clonal deletion theory and non-specific stimulation of T-helper cells are included. Thus, an idea about the origin of autoimmune disease and the qualitative description of its course is presented. Possible therapies, such as immunosuppression and extracorporeal removal of autoantibodies, are also discussed.
Waniewski
J
J
Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw.
Prikrylová
D
D
D000941:Antigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D007108:Immune Tolerance; D008954:Models, Biological
D000941:Antigens