Lanthanide-stimulated glucose and proline transport across rabbit intestinal brush-border membranes.
Trivalent cations of the lanthanide series (La3+----Yb3+) stimulated uptake of proline or glucose in rabbit small intestinal brush-border membrane vesicles. The lanthanides stimulated uptake to an extent greater than Al3+, choline, and in many cases, Na+. A time-course of Er3+-stimulated glucose uptake gave initial rates and overshoots greater than Na+ stimulation. The best activators were Sm3+, Eu3+ and Tm3+, which stimulated proline initial uptakes by 400-600%, and stimulated glucose uptake by 120-150%, compared to Na+. The best lanthanide cotransport activators possessed high third ionization potentials.
Stevens
B R
BR
Department of Physiology, College of Medicine, University of Florida, Gainesville 32610.
Kneer
C
C
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000378:metabolism*; D007477:Ions; D007700:Kinetics; D008674:Metals, Rare Earth / Q000494:pharmacology*; D008871:Microvilli / Q000378:metabolism; D011392:Proline / Q000378:metabolism*; D011817:Rabbits; D013329:Structure-Activity Relationship
D007477:Ions; D008674:Metals, Rare Earth; D011392:Proline; D005947:Glucose