[Formation of the regular, optical isotropic phase of low molecular weight DNA molecules modified by cis-dichlorodiammineplatinum].
It is shown that condensation of DNA molecules of low molecular mass (less than 1 X 10(6) in NaClO4-containing solution of poly(ethylene glycol) brings about formation of cholesteric liquid crystal phase; pattern of this phase is presented. It has been found by means of X-ray analysis and polarization microscopy that at certain level of modification with cis-dichlorodiammineplatinum (II) the DNA molecules instead of cholesteric structure form an ordered optically isotropic phase. The problem about the causes of the formation of such phase and about the pattern of spatial organisation of adjacent DNA molecules in it remains open.
Skuridin
S G
SG
Shtykova
E V
EV
Dembo
A T
AT
Badaev
N S
NS
Chel'tsov
P A
PA
D000818:Animals; D002942:Circular Dichroism; D002945:Cisplatin / Q000494:pharmacology*; D004247:DNA / Q000032:analysis* / Q000187:drug effects; D005399:Fishes; D066298:In Vitro Techniques; D008859:Microscopy, Polarization; D008970:Molecular Weight; D009690:Nucleic Acid Conformation; D011092:Polyethylene Glycols; D014961:X-Ray Diffraction
D011092:Polyethylene Glycols; D004247:DNA; D002945:Cisplatin
Obrazovanie uporiadochennoĭ, opticheski izotropnoĭ fazy molekul DNK nizkoĭ molekuliarnoĭ massy, modifitsirovannykh tsis-dikhlorodiamminplatinoĭ.