[Hypotensive effect of nifedipine in hypertension patients with different functional activity of the sympathetic-adrenal system].
Sympatho-adrenal activity (SAA) was assessed in 67 male patients with essential hypertension and 20 normal subjects. The patients were divided into 2 groups: those with increased (group 1) and normal (group 2) basal SAA. Hyperreactive and normally reactive patients were identified on the basis of plasma norepinephrine elevation in response to one-hour walking in both groups. Therapy with nifedipine alone for 3 weeks was ineffective in hyperreactive first-group patients. The efficiency of nifedipine treatment for essential hypertension may be dependent on baseline sympatho-adrenal activity and reactivity.
Bobrov
V A
VA
Polivoda
S N
SN
Konoshevich
S N
SN
Fushteĭ
I M
IM
D000311:Adrenal Glands / Q000187:drug effects* / Q000503:physiopathology; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004341:Drug Evaluation; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use*; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000503:physiopathology; D013997:Time Factors
D009543:Nifedipine
Gipotenzivnyĭ éffekt nifedipina u bol'nykh gipertonichesko bolezn'iu s razlichnoĭ funktsional'noĭ aktivnost'iu simpatiko-adrenalovoĭ sistemy.