Somatomedin-C in active and successfully treated acromegaly.
Sm-C concentrations in serum were found significantly different in either active acromegaly or following successful treatment with pituitary adenomectomy. Although after normalization of serum GH the Sm-C levels sometimes exceeded the normal range no overlap was found between both groups. Exceptionally two acromegalic patients showed elevated Sm-C levels in spite of normal GH values. Likewise, a high Sm-C concentration was found in one patient suspective of ectopic GH secretion with only moderately elevated serum GH. Sm-C determinations are judged as a good adjunct to usual diagnostic methods which in special cases of acromegaly can be even superior to measurements of serum GH.
Knappe
G
G
Clinic of Internal Medicine, Humboldt-University, Charité, Berlin/GDR.
Hesse
V
V
Jahreis
G
G
Rohde
W
W
Gerl
H
H
D000172:Acromegaly / Q000097:blood* / Q000601:surgery; D000236:Adenoma / Q000601:surgery*; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000097:blood*; D010911:Pituitary Neoplasms / Q000601:surgery*; D013002:Somatomedins / Q000097:blood*
D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone