[A study on ceftriaxone in the perinatal period].
Ceftriaxone (CTRX), a new cephem antibiotic with high activity against Gram-positive and Gram-negative bacteria, was investigated pharmacokinetically in 30 mothers in the perinatal period. The obtained results are summarized below. 1. The maximum CTRX level in the maternal serum was 135 micrograms/ml between 20 and 25 minutes after an intravenous administration of 1 g of CTRX. 2. The transfer of CTRX into the umbilical cord serum and the amniotic fluid was very good. CTRX levels in these fluids were about 20% and 10% of the maternal serum level, respectively. 3. No side effect was observed in mothers or neonates. 4. CTRX is a useful antibiotic for perinatal infections.
Takase
Z
Z
Department of Obstetrics and Gynecology, Kawasaki Medical School.
Fujiwara
M
M
Miyoshi
T
T
Nakayama
M
M
Kohmoto
Y
Y
Shirafuji
H
H
D000028:Abortion, Induced; D000653:Amniotic Fluid / Q000378:metabolism; D002443:Ceftriaxone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004716:Endometritis / Q000188:drug therapy* / Q000517:prevention & control; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005322:Premature Rupture of Fetal Membranes / Q000188:drug therapy; D006801:Humans; D007275:Injections, Intravenous; D011247:Pregnancy; D011645:Puerperal Infection / Q000188:drug therapy* / Q000517:prevention & control
D002443:Ceftriaxone