title: (+)-[3H]SK&F 10,047 binding sites in rat liver.
abstract: Stereospecific binding sites for (+)-[3H]SKF 10,047 have been demonstrated in rat liver. These binding sites were shown to be opioid receptors of the sigma type, and this was confirmed by their binding properties: reversibility, saturability, stereospecificity, effects of ions and various pharmacological drugs on (+)-[3H]SK sigma F 10,047 binding. The authors suggest that (+)-[3H]SKF 10,047 binding sites in liver and brain are a part of novel 'sigmergic' regulatory system.
authors: Laboratory of Peptide Biochemistry and Pharmacology, Institute of Experimental Cardiology, Cardiology Research Center of the USSR, Moscow.
authors: N N
authors: NN
authors: Samovilova
authors: L V
authors: LV
authors: Nagornaya
authors: V A
authors: VA
authors: Vinogradov
mesh_terms: D000818:Animals; D001665:Binding Sites; D002412:Cations / Q000494:pharmacology; D004798:Enzymes / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D010620:Phenazocine / Q000031:analogs & derivatives* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014357:Trypsin / Q000494:pharmacology; D010738:Type C Phospholipases / Q000494:pharmacology
chemical_list: D002412:Cations; D004798:Enzymes; C012134:SK&F 10047; D010738:Type C Phospholipases; D014357:Trypsin; D010620:Phenazocine