Location of angiotensin II binding sites on neuronal and glial cells of cultured mouse spinal cord: an autoradiographic study.
Cultures of mouse spinal cord were used to visualize binding sites for [125I]angiotensin II (AII) by autoradiography. Visualization by light microscopy shows that neurones, but also glial cells possess angiotensin II binding sites which are located both on soma and processes. These findings open a new field of investigation for the understanding of the physiological significance of AII in the CNS.
Simonnet
G
G
Unité de Neurobiologie des Comportements, INSERM U.176, Bordeaux, France.
Legendre
P
P
Laribi
C
C
Allard
M
M
Vincent
J D
JD
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D002478:Cells, Cultured; D007457:Iodine Radioisotopes; D051379:Mice; D009457:Neuroglia / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D011945:Receptors, Angiotensin / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*
D007457:Iodine Radioisotopes; D011945:Receptors, Angiotensin; D000804:Angiotensin II