VLDL apoprotein secretion and apo-B mRNA level in primary culture of cholesterol-loaded rabbit hepatocytes.
Incubation of cultured rabbit hepatocytes with beta very low density lipoproteins (beta-VLDL) induces a dose-dependent increase in cell cholesterol (CH) content and VLDL apoprotein (apo) B and E secretion without change in apo-B mRNA level. These data suggest that beta-VLDL may exert a stimulatory effect on hepatic apo-B production at the co-translational and/or posttranslational level.
Kosykh
V A
VA
USSR Cardiology Research Center, Academy of Medical Sciences, Moscow.
Surguchov
A P
AP
Podres
E A
EA
Novikov
D K
DK
Sudarickov
A B
AB
Berestetskaya YuV
Repin
V S
VS
Smirnov
V N
VN
D000818:Animals; D001055:Apolipoproteins B / Q000235:genetics* / Q000378:metabolism; D001057:Apolipoproteins E / Q000378:metabolism; D001059:Apoproteins / Q000378:metabolism*; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism / Q000494:pharmacology*; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000378:metabolism*; D011817:Rabbits
D001055:Apolipoproteins B; D001057:Apolipoproteins E; D001059:Apoproteins; D008079:Lipoproteins, VLDL; D012333:RNA, Messenger; D002784:Cholesterol