Outpatient treatment of Parkinson's disease.
A retrospective study of the treatment of 148 patients with severe parkinsonism is reported. After dopa preparation was introduced as a treatment for Parkinson's disease the progress of the disease has changed. More patients with first signs after 1970 had mild progression of disease compared to patients with a debut before 1970. In addition, the population with manifestations after 1970 had fewer cases of severe progression. Adverse effects of dopa treatment had been observed in 70% of the patients. After 5 years of treatment with dopa preparation, 62.1% of the patients had momentary peak-dose dyskinesia. After 2 years of treatment 14.2% of the patients had on-off effects with higher incidence after further treatment. One hundred and fifteen patients have been treated with bromocriptine, 27 patients for more than 5 years.
Wermuth
L
L
Department of Neurology, University Hospital, Odense, Denmark.
D000553:Ambulatory Care; D001545:Benserazide / Q000627:therapeutic use; D001971:Bromocriptine / Q000627:therapeutic use; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors; D004338:Drug Combinations / Q000627:therapeutic use; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use*; D010300:Parkinson Disease / Q000188:drug therapy*; D012189:Retrospective Studies
D004338:Drug Combinations; C005177:benserazide, levodopa drug combination; D001971:Bromocriptine; D007980:Levodopa; D001545:Benserazide; D002262:Carboxy-Lyases