[Effect of ionizing radiation on the chemoreceptive properties of snail giant neurons. Correction by ATP and concanavalin A].
Ionizing radiation was shown to reduce the membrane response to acetylcholine and gamma-aminobutyric acid and to modify the sensitivity of acetylcholine reactions to ouabain. The possibility was demonstrated of the postirradiation pharmacological correction of the neuronal membrane chemosensitivity by increasing the intracellular concentration of ATP and by the external application of concanavalin A. Possible mechanisms of action of ionizing radiation on the chemoreceptive properties of the neuronal membrane are discussed.
Arvanov
V L
VL
Dvoretskiĭ
A I
AI
Zimina
E V
EV
Egorova
E G
EG
Aĭrapetian
S N
SN
D000109:Acetylcholine / Q000037:antagonists & inhibitors*; D000255:Adenosine Triphosphate / Q000502:physiology*; D000818:Animals; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D003208:Concanavalin A / Q000494:pharmacology*; D018756:GABA Antagonists; D006372:Helix, Snails; D066298:In Vitro Techniques; D010042:Ouabain / Q000494:pharmacology
D018756:GABA Antagonists; D003208:Concanavalin A; D010042:Ouabain; D000255:Adenosine Triphosphate; D000109:Acetylcholine
Deĭstvie ioniziruiushcheĭ radiatsii na khemoretseptivnye svoĭstva gigantskikh neĭronov ulitki. Korrektsiia ATF i konkavalinom A.