title: Protein kinase C in the developing rat liver, heart and brain.
abstract: Ontogenic changes of protein kinase C in the rat liver, heart and cerebrum were examined from 17-day gestation until adult. Cerebral protein kinase C activity was 19 times less at 17-day fetal as compared to 15-day postnatum or older rats. The enzyme activity in the heart was generally higher in the neonatal period than the adult, but was not correlated with the previously reported alpha 1-adrenergic and cholinergic receptor ontogeny. Likewise in the liver, the enzyme activity was not correlated with previously reported alpha 1-adrenergic and vasopressin receptor ontogeny. No correlation between protein kinase C and cyclic AMP-dependent protein kinase activities was found among these tissues. The enzyme distribution expressed by a cytosol/particulate ratio of 0.72, 2.41 and 0.64 in the liver, heart and brain, respectively, in 20-day fetus was similar to adult values. We conclude that there is a discrete ontogenic pattern of protein kinase C in each organ and it does not seem to be correlated with the ontogenic pattern of hormone receptors which relate to phosphatidylinositol breakdown. The precise role of protein kinase C in relationship to growth and differentiation needs to be further investigated.
authors: Cardinal Glennon Children's Hospital, Department of Pediatrics, St. Louis University, School of Medicine, Mo.
authors: A
authors: A
authors: Noguchi
authors: J
authors: J
authors: DeGuire
authors: P
authors: P
authors: Zanaboni
mesh_terms: D000367:Age Factors; D000818:Animals; D001921:Brain / Q000196:embryology* / Q000201:enzymology; D002848:Chromatography, DEAE-Cellulose; D005260:Female; D005318:Fetal Heart / Q000201:enzymology*; D005865:Gestational Age; D008099:Liver / Q000196:embryology* / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D011247:Pregnancy; D011493:Protein Kinase C / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011494:Protein Kinases; D011493:Protein Kinase C