[Congenital hyperthyroidism caused by diaplacental exchange of thyrotropin receptor antibodies].
We describe the case of a premature baby, extremely small for date whose mother had an untreated hyperthyroidism during pregnancy. Severe symptoms of connatal hyperthyroidism appeared after a latency period of seven days. As the underlying cause we suggest the placental transmission of thyrotropin-receptor-antibodies (TRAb), which were elevated in the mother and the newborn. Main symptoms in the newborn were tachycardia, tachypnea, sweating and diarrhea.
Eyb
H
H
Universitäts-Kinderklinik Graz.
Sperger
H
H
Borkenstein
M
M
Müller
W
W
Passath
A
A
D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D006111:Graves Disease / Q000276:immunology; D006801:Humans; D006980:Hyperthyroidism / Q000151:congenital* / Q000276:immunology; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011989:Receptors, Thyrotropin / Q000276:immunology*; D013960:Thyroid Function Tests
D001323:Autoantibodies; D011989:Receptors, Thyrotropin
Connatale Hyperthyreose durch diaplazentar übertragene Thyreotropin-Rezeptoren-Antikörper (TRAK).