Cimetidine does not inhibit plasma cholinesterase activity.
Cimetidine increases the duration of action of succinylcholine several-fold by an unknown mechanism. The hydrolysis rate of succinylcholine by human plasma was measured with a modified spectrophotometric assay. At a concentration of 1-50 micrograms/ml cimetidine did not inhibit the hydrolysis of succinylcholine. It is concluded that cimetidine may have an effect at the neuromuscular junction but does not inhibit plasma cholinesterase.
Cook
D R
DR
Department of Anesthesiology, Children's Hospital of Pittsburgh, Pennsylvania.
Stiller
R L
RL
Chakravorti
S
S
Mannenhira
T
T
D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology*; D006801:Humans; D006868:Hydrolysis; D013390:Succinylcholine / Q000378:metabolism
D002800:Cholinesterase Inhibitors; D002927:Cimetidine; D013390:Succinylcholine