title: Diol lipids are activators of protein kinase C.
abstract: Diol lipids (dioleoyl- and dioctanoylethylene glycol) at relatively low concentrations (approximately 10 microM) were found to activate significantly protein kinase C in the presence of phosphatidylserine or phosphatidylinositol. Since diol lipids are widespread minor lipid constituents of many cells [(1974) Chem. Ind., 597-604], it has been suggested that they may be involved in the maintaining of basal protein kinase C activity in the absence of external stimuli.
authors: M.V. Lomonosov Moscow Institute of Fine Chemical Technology, Academy of Sciences of the USSR.
authors: S E
authors: SE
authors: Severin
authors: E K
authors: EK
authors: Tovmasyan
authors: V I
authors: VI
authors: Shvets
authors: J G
authors: JG
authors: Molotkovsky
authors: L D
authors: LD
authors: Bergelson
mesh_terms: D000255:Adenosine Triphosphate / Q000031:analogs & derivatives*; D000266:Adenylyl Imidodiphosphate / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D004789:Enzyme Activation / Q000187:drug effects; D005026:Ethylene Glycols / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000494:pharmacology; D010718:Phosphatidylserines / Q000494:pharmacology; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats
chemical_list: D005026:Ethylene Glycols; D010716:Phosphatidylinositols; D010718:Phosphatidylserines; D000266:Adenylyl Imidodiphosphate; C056214:dioctanoyl ethylene glycol; D000255:Adenosine Triphosphate; C056213:dioleoyl ethylene glycol; D011493:Protein Kinase C