Massive nonatherosclerotic myocardial infarction in sickle cell anemia.
A 30-year-old black man with proven sickle cell anemia died after five years of progressive heart failure and three clinically distinct episodes of myocardial infarction. Autopsy revealed massive ventricular myocardial fibrosis, a large left ventricular aneurysm, and an organized nonatherosclerotic thrombosis of the left coronary artery. Myocardial infarction, unassociated with atherosclerosis, has very rarely been reported in sickle cell anemia. A toxic/lethal level of amitriptyline was found at autopsy.
McCormick
W F
WF
Department of Pathology, East Tennessee State University, College of Medicine, Johnson City 37614-0002.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology* / Q000473:pathology