Cholecystokinin octapeptide increases passive avoidance latencies in rats.
Intraperitoneal injections of either 0.9% NaCl or cholecystokinin octapeptide (CCK-8) were paired with electrical footshock using a standard passive avoidance conditioning procedure for rats. Passive avoidance behavior was measured either 24 or 48 hr following the conditioning. No CCK-8 effect upon passive avoidance behavior was observed at the 24 hr test, but CCK-8 (100 micrograms/kg and 200 micrograms/kg) produced longer passive avoidance latencies at the 48 hr test. Control rats showed a decrease in passive avoidance latencies from 24 hr to 48 hr, while the CCK-8 rats did not show such a trend.
Deupree
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D
Department of Psychology, University of Arizona, Tucson 85721.
Hsiao
S
S
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004597:Electroshock; D008297:Male; D051381:Rats; D012844:Sincalide / Q000494:pharmacology*; D013997:Time Factors
D012844:Sincalide