title: Further studies in the use of monensin in the control of experimental ovine toxoplasmosis.
abstract: Monensin was fed to 69 pregnant ewes from 81 to 84 days gestation until lambing, at an estimated rate of nil, 16.8 or 27.9 mg per head per day. Ten days after the start of this regime, groups of the ewes were dosed orally with nil, 2000 or 12,000 sporulated Toxoplasma gondii oocysts. Twenty ewes given T. gondii alone (T ewes) produced 29 lambs or aborted foetuses, 16 (55.2 per cent) of which were born dead. The 39 ewes given monensin and T. gondii (M + T ewes) produced 48 lambs or aborted foetuses, 8 (16.7 per cent) of which were born dead. The 10 ewes given monensin alone produced 12 live lambs. No difference of effect was apparent between the two doses of monensin given, nor between the two doses of Toxoplasma oocysts used. Monensin alone caused no discernible problems. Not only were proportionately more live lambs born to M + T ewes than to T ewes, but they were also heavier, possibly due to a lesser "weight" of infection within the gravid uterus. We conclude that monensin fed at about 16 mg per head per day to pregnant ewes can significantly reduce losses at lambing time due to experimentally administered T. gondii.
authors: Moredun Research Institute, Edinburgh, U.K.
authors: D
authors: D
authors: Buxton
authors: D A
authors: DA
authors: Blewett
authors: A J
authors: AJ
authors: Trees
authors: C
authors: C
authors: McColgan
authors: J
authors: J
authors: Finlayson
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005260:Female; D008985:Monensin / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D012756:Sheep / Q000276:immunology; D014122:Toxoplasma / Q000302:isolation & purification; D014124:Toxoplasmosis, Animal / Q000401:mortality / Q000473:pathology / Q000517:prevention & control*; D014591:Uterine Diseases / Q000469:parasitology / Q000473:pathology
chemical_list: D008985:Monensin