title: Mannosidosis in a litter of Persian cats.
abstract: Three kittens in a litter of Persian cats showed, from the age of eight weeks, tremor, ataxia, dysmetria, progressive weakness and emaciation. Cytoplasmic vacuolation was observed in neurons, mesenchymal and epithelial cells of tissues taken post mortem. The alpha-mannosidase activity of brain tissue of one cat tested was 4.8 per cent of control values and the urine of two cats contained large amounts of mannose-rich oligosaccharides.
authors: Department of Veterinary Pathology, Faculty of Veterinary Medicine, State University of Ghent, Belgium.
authors: T
authors: T
authors: Maenhout
authors: J A
authors: JA
authors: Kint
authors: G
authors: G
authors: Dacremont
authors: R
authors: R
authors: Ducatelle
authors: J G
authors: JG
authors: Leroy
authors: J K
authors: JK
authors: Hoorens
mesh_terms: D000818:Animals; D001921:Brain / Q000648:ultrastructure; D001923:Brain Chemistry; D002371:Cat Diseases / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002415:Cats; D002855:Chromatography, Thin Layer; D005260:Female; D007525:Isoelectric Focusing; D008297:Male; D008361:Mannosidases / Q000032:analysis / Q000172:deficiency; D009844:Oligosaccharides / Q000032:analysis / Q000652:urine; D010375:Pedigree; D043323:alpha-Mannosidase; D008363:alpha-Mannosidosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*
chemical_list: D009844:Oligosaccharides; D008361:Mannosidases; D043323:alpha-Mannosidase