The influence of haematocrit on blood cyclosporin measurements in vivo.
The influence of haematocrit on blood cyclosporin measurements has been studied in 276 paired blood and plasma samples from 21 renal transplant patients. A highly significant correlation was found between blood and plasma cyclosporin concentrations, r = 0.8744, but the correlation between blood or plasma cyclosporin and haematocrit was not significant. The ratio of blood/plasma cyclosporin did not significantly increase with increasing haematocrit. It was concluded that in vivo the influence of haematocrit on the measurement of blood cyclosporin concentrations was negligible.
Johnston
A
A
Department of Clinical Pharmacology, St Bartholomew's Hospital, London.
Marsden
J T
JT
Holt
D W
DW
D003524:Cyclosporins / Q000097:blood*; D006400:Hematocrit; D006801:Humans; D011863:Radioimmunoassay
D003524:Cyclosporins