title: Pharmacokinetics of 14C-ambazone in rats.
abstract: In rats, the pharmacokinetics of 14C-ambazone after i.v. and oral administration was studied. The results demonstrate that the compound is incompletely absorbed from the gastrointestinal tract, penetrates rapidly and to a high degree into various tissues and is preferentially eliminated via the kidneys. After i.v. administration of 50 mg/kg b.m. disposition half-life in whole blood is about 6-7 h. The extent of absorption from the gastrointestinal tract is about 40%.
authors: Academy of Sciences of the GDR, Central Institute of Microbiology and Experimental Therapy, Jena.
authors: H J
authors: HJ
authors: Kühnel
authors: R
authors: R
authors: Amlacher
authors: K
authors: K
authors: Kramarczyk
authors: W
authors: W
authors: Schulze
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D001646:Bile / Q000378:metabolism; D005243:Feces / Q000032:analysis; D007275:Injections, Intravenous; D008297:Male; D008935:Mitoguazone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000970:Antineoplastic Agents; C037931:1,4-benzoquinone guanylhydrazone thiosemicarbazone; D008935:Mitoguazone