A potential role for prolactin in zinc homeostasis.
Zinc is an important trace metal co-factor for many metallo-enzymes and may have a critical role in the stabilization and function of biomembranes. Zinc-depleted animals increase their fractional absorption of zinc to restore zinc homeostasis. This increase in fractional absorption is not currently known to be hormonally-mediated. Recently, zinc has been shown to suppress the output of prolactin from dispersed pituitary cells in vitro at physiologic concentrations. Clinical states associated with a tendency to zinc deficiency are also associated with a tendency to hyperprolactinemia. These observations are consistent with the hypothesis that prolactin regulates the uptake and distribution of zinc and that zinc suppresses prolactin in closure of a negative feedback regulatory loop.
Koppelman
M C
MC
Miriam Hospital, Providence, RI 02906.
D000818:Animals; D006706:Homeostasis; D006801:Humans; D006966:Hyperprolactinemia / Q000503:physiopathology*; D010911:Pituitary Neoplasms / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism / Q000502:physiology*; D015032:Zinc / Q000172:deficiency / Q000378:metabolism*
D011388:Prolactin; D015032:Zinc