title: 3-Mercaptopropionic acid administration into the caudate-putamen of the rat provokes dyskinesia.
abstract: The unilateral administration of 3-mercaptopropionic acid (MPA) through an implanted guide cannula into the caudate-putamen produced dyskinesia in the rat. Striatal GABA and dopamine were decreased and the dopamine metabolites 3,4-dihydroxyphenylacetic and homovanillic acid were increased on the MPA-injected side at 2-10 min after the onset of dyskinesia. The dyskinetic movements were blocked by GABA or alpha-aminooxaloacetic acid but not by glycine or haloperidol.
authors: Nathan S. Kline Institute for Psychiatric Research, Center for Neurochemistry, New York, NY 10035.
authors: E
authors: E
authors: Toth
authors: A
authors: A
authors: Lajtha
mesh_terms: D015097:3-Mercaptopropionic Acid / Q000633:toxicity*; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism; D004409:Dyskinesia, Drug-Induced / Q000209:etiology* / Q000378:metabolism; D011699:Putamen / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D013438:Sulfhydryl Compounds; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D013438:Sulfhydryl Compounds; D005680:gamma-Aminobutyric Acid; D015097:3-Mercaptopropionic Acid