Collagen-type synthesis in human-hair papilla cells in culture.
Hair-papilla derived cells were grown in monolayer culture and revealed the typical morphology and growth pattern which was similar but not identical to control fibroblasts. Hair-papilla cells were found to produce considerable amounts of collagen type I and type III and fibronectin. Type IV collagen production could not be detected. The ratio of collagen type III and type I clearly differed from the pattern observed in normal fibroblasts, being much higher in hair-papilla cells, where type III accounted for more than 20% of total collagen synthesis. These data show that hair-papilla derived cells have biosynthetic capacities similar to those of human skin fibroblasts as well as characteristic differences, indicating that they represent a specialized fibroblast subpopulation.
Katsuoka
K
K
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, FRG.
Mauch
C
C
Schell
H
H
Hornstein
O P
OP
Krieg
T
T
D000328:Adult; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism; D006197:Hair / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged
D003094:Collagen