title: Changes in sialic acid and fucose contents of enterocytes across the crypt-villus axis in developing rat intestine.
abstract: Alterations in sialic acid and fucose contents of different populations of epithelial cells have been studied in suckling and adult rat intestine. The progression of cells from crypt base to villus tip is associated with an increase in sialic acid and a decrease in fucose levels of the cells in adult rats. In suckling pups, sialic acid is uniformly distributed along the length of villi, and fucose is richly (P less than 0.01) present in cryptic cells compared to that at the villus tip. Adult-type changes in sialylation and fucosylation of enterocytes across the crypt-villus axis were precociously produced by cortisone administration to suckling pups. Thyroxine treatment was less effective in influencing the glycosylation process in rat intestine.
authors: Department of Biochemistry, Panjab University, Chandigarh, India.
authors: V M
authors: VM
authors: Jaswal
authors: H S
authors: HS
authors: Babbar
authors: A
authors: A
authors: Mahmood
mesh_terms: D000818:Animals; D003348:Cortisone / Q000494:pharmacology; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D005643:Fucose / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D019158:N-Acetylneuraminic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D012794:Sialic Acids / Q000378:metabolism*; D013974:Thyroxine / Q000494:pharmacology
chemical_list: D012794:Sialic Acids; D005643:Fucose; D019158:N-Acetylneuraminic Acid; D013974:Thyroxine; D003348:Cortisone