Neurological examination, computerized tomography, cerebral blood flow and neuropsychological examination in workers with long-term exposure to carbon disulfide.
Sixteen males, formerly exposed to carbon disulfide (CS2) for at least 10 years (mean 20 years), were administered a neurological examination, cerebral computerized tomography (CT), regional cerebral blood flow (rCBF) examination and neuropsychological examination. The clinical neurological examination revealed abnormalities in 15; cerebral CT showed signs of atrophy in 13; and neuropsychological examination indicated brain organic changes in 13. With the rCBF examination, slight abnormalities were found in 8. The findings indicate that long-term exposure to CS2 involves a risk of developing toxic encephalopathy, demonstrable on both neurological and neuropsychological examination. Furthermore, structural changes in the brain may be demonstrable by cerebral CT.
Aaserud
O
O
Department of Neurology, Rikshospitalet, National Hospital, University of Oslo.
Gjerstad
L
L
Nakstad
P
P
Nyberg-Hansen
R
R
Hommeren
O J
OJ
Tvedt
B
B
Russell
D
D
Rootwelt
K
K
D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects*; D002246:Carbon Disulfide / Q000633:toxicity*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004781:Environmental Exposure; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects*; D014057:Tomography, X-Ray Computed
D002246:Carbon Disulfide