Changes in the electroencephalographic and gamma-aminobutyric acid transaminase and succinic semialdehyde dehydrogenase in the allergen induced rat brain.
Electroencephalographic activity and gamma-Aminobutyric acid Transaminase together with Succinic semialdehyde dehydrogenase activity changes produced by sensitization with Prosopis juliflora pollen allergen were studied in the cerebral cortex and hypothalamus of the rat brain. Electrical activity of EEG recording begins to appear on 3rd day after sensitization with maximum increase in activity was found on day 9 and decreased after that. A sudden increase in electrical activity was produced in 9th day sensitized rat with 10 min after giving challenging dose intravenously. The measurement of enzymatic activity of GABA-T and SSA-DH showed decrease and increase in 3, 9, 15 and 30 days sensitized rat hypothalamus and cerebral cortex whole homogenate and mitochondrial fractions. A maximum changes in enzymatic activity was found in 9th day sensitized rat with significant alterations after giving sudden stress as challenging dose. These changes in EEG activity and GABA-ergic neurotransmitter in allergenic rats showed the immunoregulatory role of nervous system mediated via GABA shunt.
Thakur
I S
IS
Department of Environmental Sciences, G.B.Pant Univ. of Agric. & Tech., Pantnagar (Nainital), India.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism*; D000445:Aldehyde Oxidoreductases / Q000378:metabolism*; D000707:Anaphylaxis / Q000201:enzymology*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000276:immunology; D002540:Cerebral Cortex / Q000276:immunology; D004569:Electroencephalography; D005260:Female; D007031:Hypothalamus / Q000276:immunology; D008297:Male; D011058:Pollen / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D050644:Succinate-Semialdehyde Dehydrogenase
D000445:Aldehyde Oxidoreductases; C493647:Aldh5a1 protein, rat; D050644:Succinate-Semialdehyde Dehydrogenase; D000612:4-Aminobutyrate Transaminase