Effects of indomethacin on non-adrenergic, non-cholinergic motility of stomach and small intestine.
Stimulation of the sectioned cervical vagal nerve of anaesthetized cats (ether-chloralose), pretreated with guanethidine and atropine, in the peripheral direction produced gastric relaxation as well as jejunal and ileal contraction. The administration of indomethacin markedly enhanced intestinal tone and the amplitude of spontaneous phasic activity while the basal gastric motility was essentially unchanged. This suggests that endogenous prostaglandins exert an inhibitory influence on intestinal motility. The vagally induced gastric relaxation was significantly inhibited by indomethacin, with could suggest that prostaglandins modulate non-adrenergic, non-cholinergic inhibitory neurotransmission in the stomach.
Gustafsson
B I
BI
Department of Surgery, University of Göteborg, Sweden.
Delbro
D S
DS
D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology*; D002415:Cats; D004558:Electric Stimulation; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D007421:Intestine, Small / Q000187:drug effects / Q000294:innervation; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D013270:Stomach / Q000187:drug effects / Q000294:innervation; D014630:Vagus Nerve / Q000502:physiology
D007213:Indomethacin