Chemotherapy versus chemotherapy with intralymphatic tumor cell vaccine in canine lymphoma.
Fifty-eight dogs with lymphoma were treated with combination chemotherapy (vincristine, cyclophosphamide, L-asparaginase, and doxorubicin HCl [VCAA]) followed by intralymphatic autochthonous tumor cell vaccine (CI). Thirty dogs received chemotherapy alone (VCAA). There was no overall significant difference in survival times between the two groups, although there was a trend toward prolonged survival in the CI group. Asymptomatic dogs (Stage A) and dogs less than 7 years of age with Stage A disease treated with CI had significantly longer survival. Dogs treated with CI had a significantly longer first remission. Regardless of treatment group, male dogs had significantly longer remission times compared with female dogs.
Jeglum
K A
KA
Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Philadelphia 19104-6010.
Young
K M
KM
Barnsley
K
K
Whereat
A
A
D000367:Age Factors; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001215:Asparaginase / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004283:Dog Diseases / Q000188:drug therapy / Q000628:therapy*; D004285:Dogs; D004317:Doxorubicin / Q000008:administration & dosage; D004338:Drug Combinations / Q000008:administration & dosage; D005069:Evaluation Studies as Topic; D005260:Female; D007167:Immunotherapy; D007272:Injections, Intralymphatic; D008223:Lymphoma / Q000188:drug therapy / Q000276:immunology / Q000628:therapy / Q000662:veterinary*; D008297:Male; D012074:Remission Induction; D014612:Vaccines / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D004338:Drug Combinations; D014612:Vaccines; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D001215:Asparaginase