title: Spin-echo 1H NMR detected response of ergothioneine to oxidative stress in the intact human erythrocyte.
abstract: Human erythrocytes were subjected to oxidative stress using arsenicals. The study is a model for thiol-related redox processes observed in the etiology of diseases such as rheumatoid arthritis. Spin-echo NMR spectroscopy of the living cell was used to monitor the cellular biochemistry. Oxidation of glutathione and the first demonstrated response of ergothioneine to a chemical stimulus in a cell were observed. The reversible nature of the ergothioneine response is interpreted as an environmental rather than a chemical change.
authors: Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, Scotland.
authors: J
authors: J
authors: Reglinski
authors: W E
authors: WE
authors: Smith
authors: R D
authors: RD
authors: Sturrock
mesh_terms: D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D004880:Ergothioneine / Q000378:metabolism*; D004912:Erythrocytes / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D010100:Oxygen / Q000502:physiology*
chemical_list: D004880:Ergothioneine; D010100:Oxygen