title: Centrifugal activity in afferent C-fibers influences the spontaneous afferent barrage generated in nerve-end neuromas.
abstract: We have investigated the effect of a prolonged, low-frequency impulse barrage on the spontaneous afferent discharge that originates in experimental nerve-end neuromas in the rat sciatic nerve. Centrifugal activity in afferent A-fibers did not affect electrogenesis in the neuroma. When C-fibers were recruited, however, over half of the axons tested were either suppressed or excited. We suggest that these effects resulted from the stimulation-evoked release of neuroactive peptides or related substances from the cut ends of afferent C-fibers.
authors: Department of Zoology, Hebrew University of Jerusalem, Israel.
authors: M
authors: M
authors: Devor
authors: R
authors: R
authors: Dubner
mesh_terms: D000344:Afferent Pathways / Q000503:physiopathology*; D000818:Animals; D004558:Electric Stimulation; D008297:Male; D009411:Nerve Endings / Q000503:physiopathology*; D009463:Neuroma / Q000503:physiopathology*; D010524:Peripheral Nervous System Neoplasms / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000503:physiopathology*