title: Nasal response to allergen and hyperosmolar challenge.
abstract: Rhinitis causes both clinical and social discomfort to patients, and in clinical practice is often underdiagnosed. We have examined a simple method for the assessment of a positive nasal provocation test to help in the diagnosis of rhinitis. In patients with histories suggestive of house dust mite (HDM) sensitivity and positive skin-prick tests or specific IgE to Dermatophagoides pteronyssinus, there was a fall in nasal inspiratory peak flow (NIPF) following nasal challenge with allergen. This was not seen in control subjects or in pollen-sensitive patients when challenged with house dust mite. Frequency of sneezing and degree of rhinorrhoea increased in these patients following challenge, and based on these findings we propose a simplified scoring system for the diagnosis of allergic rhinitis. We examined non-specific nasal reactivity using hyperosmolar solutions as a challenge system and found that allergic subjects responded with a fall in NIPF, although the clinical response was not identical to that seen with allergen. Control subjects did not respond to hyperosmolar challenge.
authors: Department of Immunology, University College and Middlesex School of Medicine, London, U.K.
authors: M C
authors: MC
authors: Krayenbuhl
authors: B N
authors: BN
authors: Hudspith
authors: G K
authors: GK
authors: Scadding
authors: J
authors: J
authors: Brostoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009666:Nose / Q000276:immunology*; D009994:Osmolar Concentration; D010159:Palate / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology; D012912:Sneezing
chemical_list: D000485:Allergens