Serological examination of IgE- and IgG-specific antibodies to egg protein during influenza virus immunization.
The concentrations of serum IgE (PRIST) and IgE- and IgG-specific antibodies to egg protein were determined in paired sera taken from students who had received influenza virus vaccine. Although persons who gave a history of allergy to egg or to chicken feathers were excluded, 10-16% of vaccinees possessed higher titres of serum IgE and IgE-specific antibody (RAST) to egg white (F1) allergen before vaccination. The titres of IgG-specific antibody to egg protein (ovalbumin and ovomucoid antigens) were negligible, and did not show any significant response after vaccination. In contrast, IgE-specific antibody to F1 allergen rose significantly in a considerable number of the vaccines. The results obtained indicate possible contamination of vaccine products with allergens of egg origin and a potential risk of allergic manifestation after influenza vaccination.
Yamane
N
N
Department of Laboratory Medicine, Kumamoto University Medical School, Japan.
Uemura
H
H
D000485:Allergens / Q000276:immunology*; D004527:Egg Proteins / Q000276:immunology*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D009980:Influenza A virus / Q000276:immunology; D009981:Influenza B virus / Q000276:immunology; D007252:Influenza Vaccines / Q000009:adverse effects / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D010059:Ovomucin / Q000276:immunology; D014611:Vaccination
D000485:Allergens; D004527:Egg Proteins; D007074:Immunoglobulin G; D007252:Influenza Vaccines; D010059:Ovomucin; D007073:Immunoglobulin E; D010047:Ovalbumin