The elimination of spermidine from plasma in rats.
Infused spermidine in rats with bypassed livers was eliminated very slowly, whereas endogenous spermidine in saline-infused controls with bypassed livers increased. In the same animals endogenous putrescine plasma levels did not differ significantly between spermidine- or saline-infused animals, whereas endogenous cadaverine levels increased during spermidine infusion and decreased afterwards. It is concluded that the liver is the most important site for plasma spermidine elimination.
Emonds
A
A
Dept. of Pharmacology, University of Leiden, The Netherlands.
van de Ven
M
M
Hermans
J
J
Driessen
O
O
D000818:Animals; D002103:Cadaverine / Q000097:blood; D005260:Female; D006207:Half-Life; D007262:Infusions, Intravenous; D008099:Liver / Q000378:metabolism; D011700:Putrescine / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013095:Spermidine / Q000097:blood* / Q000493:pharmacokinetics
D002103:Cadaverine; D013095:Spermidine; D011700:Putrescine