[Morphofunctional changes in the pancreas in response to dalargin under normal conditions and in experimental pancreatitis].
The influence of dalargin on pancreatic secretion stimulated by different agents has been studied in experiments on dogs. Intravenous infusion of dalargin (50 micrograms/kg/hour) induced intensive inhibition of both secretion volume and protease content. The data have been obtained on a positive influence of dalargin on acute experimental pancreatitis in rats. A reduction in synthetic processes in acinar cells, reestablishment of microcirculation in the affected zones and the absence of disturbances in the marginal zones of the pancreas have been observed.
Kurzanov
A N
AN
Titova
G P
GP
Vinogradov
V A
VA
Aleĭnik
V A
VA
Gerasimov
N F
NF
D000208:Acute Disease; D000818:Animals; D004285:Dogs; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010189:Pancreatic Juice / Q000378:metabolism; D010195:Pancreatitis / Q000188:drug therapy*; D051381:Rats
D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Morfofunktsional'nye izmeneniia podzheludochnoĭ zhelezy pod vliianiemdalargina v norme i pri éksperimental'nom pankreatite.