title: Diffuse necrotizing tracheobronchitis: an acute and chronic disease.
abstract: Necrotizing tracheobronchitis (NTB) is characterized by acute episodes of airway obstruction, hypercarbia, and lack of chest movement in mechanically ventilated neonates. Emergency bronchoscopic removal of necrotic tissue is essential for survival. Although postmortem lesions extend into smaller bronchi, survivors have not demonstrated residual tracheobronchial abnormalities. Two infants were treated successfully for NTB but succumbed to diffuse tracheobronchial strictures with progressive pulmonary hyperinflation. A third neonate with esophageal atresia and left pulmonary agenesis developed NTB. Despite initial postbronchoscopic improvement, the infant died at age 6 weeks with diffuse obstructing NTB. All three infants required endotracheal intubation and mechanical ventilation. High-frequency jet ventilation was not used. Tracheal cultures for fungi, bacteria and viruses were negative. Successful treatment of NTB may be followed acutely by recurrence of NTB and chronically by diffuse tracheobronchial strictures and emphysema.
authors: Department of Pediatric Surgery, Children's Hospital of Eastern Ontario, Ottawa, Canada.
authors: S Z
authors: SZ
authors: Rubin
authors: C L
authors: CL
authors: Trevenen
authors: I
authors: I
authors: Mitchell
mesh_terms: D000208:Acute Disease; D000402:Airway Obstruction / Q000209:etiology / Q000628:therapy; D001991:Bronchitis / Q000209:etiology* / Q000628:therapy; D002908:Chronic Disease; D006801:Humans; D007231:Infant, Newborn; D009336:Necrosis; D012121:Respiration, Artificial / Q000009:adverse effects*; D014136:Tracheitis / Q000209:etiology* / Q000628:therapy