Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene.
We isolated and sequenced a cDNA clone of the human gene encoded by the 5' half of the ret transforming gene. The nucleotide sequence indicates that it encodes a protein with "finger" structures which represent putative metal- and nucleic acid-binding domains. Transcription of this gene was detected at high levels in a variety of human and rodent tumor cell lines, mouse testis, and embryos. In addition, a unique transcript was observed in testis RNA. When the expression of the unique transcript was examined at different stages of spermatogenesis, a striking increase in mRNA levels accompanied progression from meiotic prophase pachytene spermatocytes to postmeiotic round spermatids. This finger-containing gene may thus function in male germ cell development.
Takahashi
M
M
Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan.
Inaguma
Y
Y
Hiai
H
H
Hirose
F
F
D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D002461:Cell Line, Transformed; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics; D014158:Transcription, Genetic
D011506:Proteins; D004247:DNA