Technique for aerosol deposition restricted to the nose in beagle dogs.
A method was developed for exposing the nasal cavity of beagle dogs to a radiolabeled aerosol without exposure of the remainder of the respiratory tract. Deposition efficiency, using a test aerosol of 2.0-micron particles of 99mTc-sulfur colloid delivered to the nose, was 15 +/- 2% (mean +/- SE) of inhaled activity. Gamma camera imaging showed that maximum deposition occurred in the anterior third of the nasal cavity, which contained 78 +/- 4% (mean +/- SE) of the total deposited radioactivity. The middle-third of the nasal cavity received 13 +/- 3% and the posterior third 9 +/- 2% of the deposited radioactivity. Aerosol deposition in regions of the respiratory tract below the larynx was not detectable.
Whaley
S L
SL
Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico 87185.
Renken
S
S
Muggenburg
B A
BA
Wolff
R K
RK
D000280:Administration, Inhalation / Q000379:methods*; D000336:Aerosols / Q000032:analysis; D000818:Animals; D004285:Dogs; D008297:Male; D009296:Nasal Cavity / Q000032:analysis*; D010316:Particle Size; D013671:Technetium Tc 99m Sulfur Colloid / Q000008:administration & dosage / Q000032:analysis
D000336:Aerosols; D013671:Technetium Tc 99m Sulfur Colloid