Immunopurified anti-müllerian hormone does not inhibit spontaneous resumption of meiosis in vitro of rat oocytes.
The ability of immunopurified, biologically potent anti-Müllerian hormone (AMH) to inhibit the spontaneous resumption of meiosis of rat oocytes was tested in vitro. Two different batches of AMH in the range of 0.75-9.0 micrograms/protein did not suppress the spontaneous resumption of meiosis. Neither did AMH (6 micrograms/ml) induce meiotic resumption of follicle-enclosed oocytes in culture. It is concluded, therefore, that AMH has no oocyte meiosis-inhibiting activity.
Tsafriri
A
A
Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.
Picard
J Y
JY
Josso
N
N
D000818:Animals; D054304:Anti-Mullerian Hormone; D005260:Female; D006023:Glycoproteins; D006131:Growth Inhibitors; D008540:Meiosis / Q000187:drug effects*; D009095:Mullerian Ducts; D009865:Oocytes / Q000166:cytology* / Q000187:drug effects; D006080:Ovarian Follicle / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013735:Testicular Hormones / Q000302:isolation & purification / Q000494:pharmacology*
D006023:Glycoproteins; D006131:Growth Inhibitors; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone