title: Increase in basal pulse rate and blood pressure by the diabetic state in KK-CAy mice, alloxan-mice and streptozotocin-mice.
abstract: Basal pulse rate (PR) and systolic blood pressure (BP) in the tail artery of diabetic KK-CAy mice were compared with those of alloxan- or streptozotocin (STZ)-induced diabetic ddY mice. Significantly higher PR and BP were obtained by the above three kinds of diabetic states when compared with the pre-diabetic state (KK-CAy) or the non-diabetic state (ddY mice). The PR and BP alteration in diabetic KK-CAy mice were significantly different from the PR one in alloxan-mice and from the BP one in STZ-mice, respectively. Both increases in PR and BP by the diabetic state suggest an anticholinergic state.
authors: Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
authors: I
authors: I
authors: Kimura
authors: T
authors: T
authors: Matsui
authors: M
authors: M
authors: Kimura
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011674:Pulse
chemical_list: D001786:Blood Glucose