title: HLA and multiple skin carcinomas.
abstract: The presence of HLA-associated genetic factors in patients with multiple skin carcinomas was investigated. 43 patients affected by multiple basal and squamous cell carcinomas and 220 healthy age-matched controls were typed for 72 HLA-A, B, C, DR antigens. A negative association of B-17 (mostly B-58) and a positive association of Cw-3 and DR-1 was observed in patients with multiple basal cell carcinomas; a similar negative association with B-58 and positive association with DR-1 was seen in patients with squamous cell carcinomas. The results of this study suggest the presence of resistance factors to the development of skin cancers associated with B-17 (B-58) antigen.
authors: Institute of Dermatology, University of Sassari, Italy.
authors: D
authors: D
authors: Cerimele
authors: L
authors: L
authors: Contu
authors: C
authors: C
authors: Carcassi
authors: G
authors: G
authors: Costa
authors: G
authors: G
authors: La Nasa
authors: E
authors: E
authors: Sanna
authors: G V
authors: GV
authors: Campus
mesh_terms: D002280:Basal Cell Carcinoma / Q000235:genetics / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D006681:HLA-D Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D006681:HLA-D Antigens; D006684:HLA-DR Antigens