title: Vasoconstrictor-induced changes in renal blood flow: role of prostaglandins and histamine.
abstract: The role of histamine (H) and prostaglandins (PGs) in the renal vasoconstriction prompted by a 10-min intrarenal infusion of norepinephrine (NE, 0.2 micrograms), antidiuretic hormone (ADH, 10 mU), or angiotensin II (ANG II, 0.05 micrograms) was evaluated in anesthetized dogs (amounts are per min per kg). Renal blood flow (RBF, flow probe) decreased four- to fivefold during the 1st min of infusion with each agonist but then gradually returned toward base line. This "escape" was greatest with ADH, less with NE, and small with ANG II. There was a postinfusion reactive hyperemia (RH) only after NE; NE-RH was 4.26 +/- 0.75 (SE) ml/g. Meclofenamate (MFA) reduced NE-RH to 60 +/- 11% of control and decreased NE escape. The H1-receptor antagonist, chlorpheniramine (CP), decreased NE-RH to 24 +/- 5% of control and reduced NE escape. MFA slowed, but did not block, ADH escape and had little effect on ANG II escape. CP did not affect ADH or ANG II escape. The histidine decarboxylase inhibitor, p-toluenesulfonohydrazine, did not affect NE escape but decreased NE-RH to 22 +/- 6% of control. Bolus injections of ADH during a constant infusion of the hormone were not vasoactive, indicating a tachyphylaxis-like phenomenon; this was not found with ANG II or NE. Finally, the excretion of histamine-like material increased from a control value of 0.69 +/- 0.08 to 1.28 +/- 0.28 micrograms/min during NE-RH. These results indicate that NE releases histamine and PGs from the kidney and that PGs account, primarily, for NE escape, whereas histamine accounts, primarily, for NE-RH.
authors: Department of Physiology and Biophysics, University of Cincinnati College of Medicine, Ohio 45267-0576.
authors: R O
authors: RO
authors: Banks
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002744:Chlorpheniramine / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors; D008297:Male; D008469:Meclofenamic Acid / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D012079:Renal Circulation / Q000187:drug effects*; D014105:Tosyl Compounds / Q000494:pharmacology*; D014667:Vasopressins / Q000494:pharmacology*; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
chemical_list: D014105:Tosyl Compounds; D062367:ortho-Aminobenzoates; D014667:Vasopressins; D000804:Angiotensin II; D002744:Chlorpheniramine; D008469:Meclofenamic Acid; D006640:Histidine Decarboxylase; C002030:4-toluenesulfonyl hydrazide; D009638:Norepinephrine