Involvement of the medial amygdaloid nucleus in the action of imipramine in rats subjected to the forced swimming test.
A forced swimming test proposed by Porsolt is a useful method for screening antidepressants. To evaluate drug effects more objectively, vibration of the walls of a water tank caused by the escape behavior of the rat was recorded. Imipramine (IMI) increased the number of vibration and this effect was observed in the medial amygdala lesioned rat but not in the central or basolateral amygdala lesioned rat. The present result suggests that the medial amygdala is an important site of action of IMI.
Shimazoe
T
T
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Shibata
S
S
Yatsugi
S
S
Ueki
S
S
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001931:Brain Mapping; D004924:Escape Reaction / Q000187:drug effects; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D005082:Physical Exertion / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming
D007099:Imipramine