title: Degradation products of irradiated haloperidol: implications for the development of an implantible delivery system.
abstract: Haloperidol was chosen as a model compound to determine whether the degradation products created by sterilizing dose of gamma radiation would contaminate an implantible delivery device and be hazardous to the health of the person using it. Acrolein, chlorobenzene, and several other products were identified among the degradation products. They were quantitated and evaluated as being potentially dangerous. It is recommended that the development protocol for a radiation-sterilized, implantible drug include the identification and evaluation of the degradation products.
authors: Analytical Research Laboratory, Kimberly-Clark Corporation, Neenah, Wisconsin.
authors: J
authors: J
authors: Booker
mesh_terms: D004343:Drug Implants; D005720:Gamma Rays; D008401:Gas Chromatography-Mass Spectrometry; D006220:Haloperidol / Q000008:administration & dosage / Q000032:analysis* / Q000528:radiation effects
chemical_list: D004343:Drug Implants; D006220:Haloperidol