Vascular injuries induced by materials released from platelet-rich thrombus in vivo.
Polyethylene tubing was inserted into the ascending aorta of rabbits via the right common carotid artery and placed for one or four weeks continuously to induce vessel wall injury and thrombotic events, and then the direct non-injured segments from the descending thoracic and abdominal aorta were examined morphologically and for [3H]thymidine incorporation into endothelial cells and smooth muscle cells. The descending aortas of experimental rabbits showed endothelial damage and increased mitosis of endothelial cells. [3H]Thymidine incorporation into the intima and media was significantly increased in the experimental group. This experiment indicates that materials released from activated platelets and/or thrombi into the circulation can cause endothelial damage and smooth muscle cell proliferation at downstream and remote aortic segments.
Asada
Y
Y
Department of Pathology, Miyazaki Medical College, Japan.
Hayashi
T
T
Sumiyoshi
A
A
D000818:Animals; D001011:Aorta; D001792:Blood Platelets / Q000378:metabolism / Q000473:pathology* / Q000502:physiology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology* / Q000648:ultrastructure; D008297:Male; D010974:Platelet Aggregation; D011817:Rabbits; D013927:Thrombosis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D013936:Thymidine / Q000378:metabolism
D013936:Thymidine