title: Sugar receptors of different types in human metastases to lung and liver.
abstract: Endogenous sugar receptors of human tumors, supposedly involved in recognitive interactions and growth regulation, were comparatively analyzed from human metastases to lung and liver by affinity chromatography and subsequent sodium dodecyl sulfate-polyacrylamide gel electrophoresis. These profiles of sugar receptors including Ca2+-dependent and Ca2+-independent specificities to alpha- and beta-galactosides, alpha-mannosyl and alpha-fucosyl moieties from salt and detergent extracts were found to be significantly different from the profile of the corresponding normal tissue. Metastatic lesions to lung from three different types of primary tumors revealed primarily tumor-associated mannan- and galactoside-binding proteins, whereas different liver metastases showed a tendency towards preferential expression of additional beta-galactoside-binding proteins and, to a reduced extent, fucose-binding proteins. The patterns of two metastatic lesions to lung and liver from a similar primary tumor, a colon carcinoma, disclose significant differences. Each resembles the pattern of other metastases to the same target organ more than it resembles the pattern of metastatic lesions to the other target organ, derived from a similar primary tumor. Further analyses of two primary liver tumors underscore the significance of changes in such a pattern upon malignant transformation.
authors: Max-Planck-Institut für experimentelle Medizin, Abteilung Chemie, Göttingen, FRG.
authors: H J
authors: HJ
authors: Gabius
authors: R
authors: R
authors: Engelhardt
mesh_terms: D002118:Calcium / Q000494:pharmacology; D002352:Carrier Proteins; D003110:Colonic Neoplasms / Q000473:pathology; D004591:Electrophoresis, Polyacrylamide Gel; D005643:Fucose / Q000378:metabolism; D005697:Galactosides / Q000378:metabolism; D006801:Humans; D037181:Lectins, C-Type; D008113:Liver Neoplasms / Q000556:secondary*; D008175:Lung Neoplasms / Q000556:secondary*; D008358:Mannose / Q000378:metabolism; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D008970:Molecular Weight; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic / Q000032:analysis*
chemical_list: D002352:Carrier Proteins; D005697:Galactosides; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D005643:Fucose; D008358:Mannose; D002118:Calcium