The metabolism of 35S-D-penicillamine in man.
1. The excretion and metabolism of 35S-D-penicillamine (200 mg orally) was studied in four healthy male volunteers. 2. The major route of excretion was the urine with 82% of the administered dose being voided over three days (73% during the first 24 h); the remainder was excreted in the faeces. 3. Metabolism occurred via the pathways of S-methylation, N-acetylation and disulphide formation. Extensive degradation of the molecule was observed with the production of large amounts of inorganic sulphate.
Waring
R H
RH
Department of Biochemistry, University of Birmingham, Edgbaston, UK.
Mitchell
S C
SC
D000284:Administration, Oral; D000328:Adult; D002845:Chromatography; D005243:Feces / Q000032:analysis; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D010396:Penicillamine / Q000493:pharmacokinetics*; D013431:Sulfates / Q000378:metabolism
D013431:Sulfates; D010396:Penicillamine