[Anti-neurofilament antibodies in slow infections of the nervous system].
Twenty-six patients including 12 with lateral amyotrophic sclerosis, 7 with multiple sclerosis, 5 with the Creutzfeld-Jakob disease and 2 with Alzheimer's disease were examined. Antibodies to neurofilaments in the blood serum were detected in all cases of the Creutzfeld-Jakob disease and Alzheimer's disease and in 8 patients with lateral amyotrophic sclerosis with clinical evidence of supranuclear structure involvement. A conclusion is drawn about a certain similarity of pathogenic mechanisms of these diseases, as well as about heterogeneity of the cytoskeleton of neurons in the brain and the spinal cord.
Zavalishin
I A
IA
Pogodina
V V
VV
Roikhel'
V M
VM
Fokina
G I
GI
Niiazbekova
A S
AS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000209:etiology / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D001921:Brain / Q000276:immunology* / Q000648:ultrastructure; D003599:Cytoskeleton / Q000276:immunology*; D005260:Female; D006801:Humans; D007382:Intermediate Filaments / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000209:etiology / Q000276:immunology; D012897:Slow Virus Diseases / Q000276:immunology*; D013116:Spinal Cord / Q000276:immunology* / Q000648:ultrastructure
D000914:Antibodies, Viral; D001323:Autoantibodies
Antitela k neĭrofilamentam pri medlennykh infektsiiakh nervnoĭ sistemy.