[Experimental evaluation of the specific and toxic properties of the liposome form of triombrast (verografin)].
In experiments on mice, rats, rabbits and dogs it was found that liposome-incapsulated triombrast administered intravenously possesses specific properties of contrasting the liver and spleen. It accumulates predominantly in these organs and 80% of 125I-labeled triombrast is excreted within the first 24 hours, the rest amount is excreted within the first week. It was also shown that the drug conforms to safety standards of the Pharmacological Committee of the USSR Ministry of Health.
Rozenberg
O A
OA
Mikhaĭlova
N Ia
NIa
Dolgopiatova
M A
MA
Loshakova
L V
LV
Makar'eva
N V
NV
D000818:Animals; D003974:Diatrizoate Meglumine / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D007457:Iodine Radioisotopes; D007928:Lethal Dose 50; D008081:Liposomes / Q000008:administration & dosage*; D051379:Mice; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D007457:Iodine Radioisotopes; D008081:Liposomes; D003974:Diatrizoate Meglumine
Eksperimental'naia otsenka spetsificheskikh i toksicheskikh svoĭstv liposomnoĭ formy triombrasta (verografina).