The role of GABA in morphine abstinence in rats.
GABA mimetics such as baclofen, aminooxyacetic acid (AOAA) and diazepam decreased naloxone-precipitated abstinence wet dog shakes in morphine dependent rats. The GABA antagonists bicuculline and picrotoxin were not effective in small doses. The inhibition of wet dog shakes by baclofen, AOAA and diazepam was not reversed by bicuculline. This suggests that baclofen, AOAA and diazepam may inhibit morphine wet dog shakes not by direct GABA receptor stimulation. Inhibition by baclofen of wet dog shakes was reversed by 5-hydroxytryptophan (5-HTP) suggesting that the inhibiting effects of GABA mimetics are mediated by serotoninergic neurons.
Kruszewska
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Department of Pharmacodynamics, Medical Academy, Lublin, Poland.
D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000096:biosynthesis; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000625:Aminooxyacetic Acid; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D009020:Morphine; D001418:Baclofen; D003975:Diazepam; D001640:Bicuculline