A phenomenological model for lipid-protein bilayers with critical mixing.
A Landau expansion of free energy in terms of area/lipid has been used to obtain protein-lipid phase diagrams with critical mixing and a maximum phase separation concentration. Simulations using this model indicate that differential scanning calorimetry scan shapes and transition enthalpies observed for lipid-synthetic peptide mixtures are consistent with this type of phase diagram. The critical mixing point and the homogeneous mixture critical point are distinguished.
Morrow
M R
MR
Department of Physics, Memorial University of Newfoundland, St. John's, Canada.
Whitehead
J P
JP
D015060:1,2-Dipalmitoylphosphatidylcholine; D002152:Calorimetry, Differential Scanning; D008051:Lipid Bilayers; D009682:Magnetic Resonance Spectroscopy; D008563:Membrane Lipids; D008565:Membrane Proteins; D008954:Models, Biological; D013816:Thermodynamics
D008051:Lipid Bilayers; D008563:Membrane Lipids; D008565:Membrane Proteins; D015060:1,2-Dipalmitoylphosphatidylcholine