[Changes in the biochemical and morphological indices of structural disturbance in the peri-infarct area of the myocardium as affected by opioid peptides in an experiment].
The effect of opiate peptides (leu-enkephalin, met-enkephalin and beta-endorphin) as well as of enkephalin synthetic analogs (two tetrapeptides and dalargin hexapeptide) on the activity of blood enzymes CPK and LDG1, the scope of myocardial infarction and ultrastructure of periinfarction cardiomyocytes has been studied on 200 white outbred rats with simulated myocardial infarction. The endogenous opiate peptides and dalargin hexapeptide were found to significantly decrease CPK and LDG1 activity and to diminish the size of the infarction. The effect is related to the drugs influence on the survival of periinfarction cardiomyocytes that can be proved electron-microscopically and using colloid lanthanum test.
Khlystov
V V
VV
Pavlenko
V S
VS
Usynin
A F
AF
Slepushkin
V D
VD
D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D004353:Drug Evaluation, Preclinical; D004723:Endorphins / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D009206:Myocardium / Q000201:enzymology* / Q000648:ultrastructure; D051381:Rats
D004723:Endorphins; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase
Izmenenie biokhimicheskikh i morfologicheskikh pokazateleĭ narusheniia struktury okoloinfarktnoĭ zony miokarda pod vliianiem opioidnykh peptidov v éksperimente.