Penetration of roxithromycin in bronchial secretions.
Roxithromycin sputum and serum concentrations after administration of therapeutic doses (150 mg in a single dose) were evaluated in six patients. Blood samples and pooled sputum samples were collected at corresponding time intervals up to 24 h after drug administration. Roxithromycin sputum levels were found to be almost always above serum concentrations, the highest sputum levels being 5.85 +/- 2.5 micrograms/ml in the interval ranging from 2 to 4 h after drug administration. Due to its antibacterial spectrum and favourable pharmacokinetic properties, roxithromycin, like other macrolide antibiotics, seems to be particularly indicated in the treatment of respiratory tract infections.
De Rose
V
V
Institute of Respiratory Diseases, University of Pavia, Italy.
Ferrara
A
A
Mangiarotti
P
P
Nonis
A
A
Bertoletti
R
R
Gialdroni Grassi
G
G
D000367:Age Factors; D000368:Aged; D001980:Bronchi / Q000378:metabolism*; D001991:Bronchitis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007933:Leucomycins / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D013183:Sputum / Q000032:analysis*
D007933:Leucomycins