title: [Contribution of bactericidal rate in the initial treatment of severe staphylococcal infections in children].
abstract: Rapid bactericidal effect is essential for therapy of severe Staphylococcus aureus infections in children. The in vitro activity of clinically achievable levels of vancomycin and its combinations with gentamicin, amikacin and rifampin plus amikacin was studied with the time-kill curve method at 2.5, 4, 6, 24 and 48 hours against 20 strains of Staphylococcus aureus isolated from children with severe staphylococcal infection. Vancomycin alone exerted a bactericidal effect at 48 hours. However, with the combinations vancomycin plus gentamicin, vancomycin plus amikacin and vancomycin plus amikacin plus rifampin a bactericidal effect was respectively observed at 24, 6 and 4 hours. Most rapid killing was achieved with vancomycin plus rifampin plus amikacin. Thus this antibiotic combination seems the most appropriate for initial treatment of severe staphylococcal infections in children.
authors: Laboratoire de Bactériologie, Hôpital Bretonneau, Paris.
authors: E
authors: E
authors: Bingen
authors: N
authors: N
authors: Lambert-Zechovsky
authors: F
authors: F
authors: Beaufils
authors: J C
authors: JC
authors: Mercier
authors: R
authors: R
authors: Cohen
authors: J C
authors: JC
authors: Roze
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008826:Microbial Sensitivity Tests; D018805:Sepsis / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Apport de la vitesse de bactéricidie dans le traitement initial des infections graves à staphylocoque de l'enfant.