Structural basis for autogenous regulation of Xenopus laevis ribosomal protein L1 synthesis at the splicing level.
It is known that the injection of the Xenopus laevis ribosomal protein L1 gene into oocytes causes the accumulation of immature L1 transcripts due to a specific block of splicing of the second and third introns. In this paper the secondary structures of these introns in pre-mRNA have been constructed. It has been shown that they share homology with 28 S rRNA. The putative RNA-binding segment of L1 has also been predicted. These results are interpreted as the structural basis for autogenous regulation of X. laevis ribosomal protein L1 synthesis at the splicing level.
Gultyaev
A P
AP
All-Union Scientific Research Institute of Genetics, Leningrad, USSR.
Shestopalov
B V
BV
D000818:Animals; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics; D001483:Base Sequence; D001665:Binding Sites; D007438:Introns; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012322:RNA Precursors / Q000235:genetics*; D012326:RNA Splicing; D012339:RNA, Ribosomal, 28S / Q000235:genetics; D012269:Ribosomal Proteins / Q000096:biosynthesis* / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D014982:Xenopus laevis
D001426:Bacterial Proteins; D012322:RNA Precursors; D012339:RNA, Ribosomal, 28S; D012269:Ribosomal Proteins; C028546:ribosomal protein L1