Factors associated with premature medication discontinuation among responders to an MAOI or a tricyclic antidepressant.
The charts of 80 outpatients who responded to antidepressants were reviewed to determine if there was a higher rate of premature medication discontinuation with phenelzine than with imipramine. The phenelzine responders had a significantly (p less than .01) higher rate of drug discontinuation, mainly because of side effects. Controlled studies of long-term use are needed to better explain the problem of attrition.
Agosti
V
V
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York.
Stewart
J W
JW
Quitkin
F M
FM
Rabkin
J G
JG
McGrath
P J
PJ
Markowitz
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010352:Patient Dropouts; D010624:Phenelzine / Q000009:adverse effects / Q000627:therapeutic use*
D010624:Phenelzine; D007099:Imipramine