Effect of the antihypertensive drug hydralazine on mineral metabolism in the rat.
The effects of hydralazine (HZ) on mineral metabolism was investigated in rats. Sprague-Dawley rats were fed HZ (0.1-4%, w/w) in three separate experiments: (1) a 2-week dose-response study; (2) a 2-month long-term feeding study; and (3) a pregnancy study. At the end of each experiment, tissues were removed and concentrations of Mn, Cu, Zn and Fe were measured. Results from the three experiments were similar. HZ had no effect on tissue Mn and Zn concentrations, while tissue Fe concentrations were lower and kidney Cu concentrations were higher in HZ-treated groups compared to controls. The effect of HZ on mineral metabolism may be, in part, responsible for some of its negative side effects.
Peters
J M
JM
Department of Nutrition, University of California, Davis 95616.
Lönnerdal
B
B
Keen
C L
CL
D000818:Animals; D003300:Copper / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006830:Hydralazine / Q000633:toxicity*; D007501:Iron / Q000378:metabolism; D008345:Manganese / Q000378:metabolism; D008903:Minerals / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000378:metabolism
D008903:Minerals; D006830:Hydralazine; D008345:Manganese; D003300:Copper; D007501:Iron; D015032:Zinc