Comparative evaluation of two direct compression lactose grades for pyridoxine hydrochloride tablets.
Fast flow lactose (FFL) and anhydrous lactose (AHL) were comparatively investigated for the manufacture of pyridoxine hydrochloride tablets. The results showed that drug/FFL formulations possessed better performance. Harder tablets were, however, compressed from AHL blends. Linear relationships which correlate tablet physical properties to excipient concentration in a given formulation were established. Tablet batches formulated with FFL dissolved in shorter times und showed better stability characteristics on aging.
Aly
S A
SA
Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka.
Udeala
O K
OK
D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D004356:Drug Storage; D005079:Excipients; D006244:Hardness; D007785:Lactose / Q000032:analysis*; D011736:Pyridoxine / Q000032:analysis*; D012995:Solubility; D013607:Tablets; D013696:Temperature; D014815:Vitamins / Q000032:analysis
D005079:Excipients; D013607:Tablets; D014815:Vitamins; D007785:Lactose; D011736:Pyridoxine