title: Prostatic carcinogenesis evoked by cellular interaction.
abstract: Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model offers a novel mechanism for prostatic carcinogenesis in which prostatic fibroblasts determine epithelial growth, androgen responsiveness, and tumorigenicity. Our results emphasize the potential importance of an epigenetic pathway in prostatic carcinogenesis.
authors: Department of Urology, University of Texas M.D. Anderson Hospital and Tumor Institute, Houston 77030.
authors: L W
authors: LW
authors: Chung
authors: S M
authors: SM
authors: Chang
authors: C
authors: C
authors: Bell
authors: H
authors: H
authors: Zhau
authors: J Y
authors: JY
authors: Ro
authors: A C
authors: AC
authors: von Eschenbach
mesh_terms: D000728:Androgens / Q000502:physiology*; D000818:Animals; D013196:Dihydrotestosterone / Q000494:pharmacology; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D005347:Fibroblasts / Q000473:pathology; D008297:Male; D009376:Neoplasms, Hormone-Dependent / Q000209:etiology*; D011471:Prostatic Neoplasms / Q000209:etiology*; D051381:Rats; D014407:Tumor Cells, Cultured
chemical_list: D000728:Androgens; D013196:Dihydrotestosterone