title: [Biotechnological grounds for the regulation of the component composition of cephalosporins in cultures of Acremonium chrysogenum].
abstract: The dynamics of cephalosporine C and desacetylcephalosporine C alterations in cultures of Acremonium chrysogenum 309A under different conditions was studied. It was shown expedient to determine the fermantation period by the data of HPLC. Genetic predisposition of the strain used to production of both cephalosporine C and desacetylcephalosporine C is discussed. With changing the cultivation procedure, medium active acidity and cultivation time it is possible to change the biosynthesis pathway.
authors.forename: L I
authors.initials: LI
authors.lastname: Iunkerova
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Bartoshevich
authors.forename: O D
authors.initials: OD
authors.lastname: Iudina
authors.forename: M I
authors.initials: MI
authors.lastname: Novak
authors.forename: V F
authors.initials: VF
authors.lastname: Belianina
authors.forename: V L
authors.initials: VL
authors.lastname: Egorov
mesh_terms: D000164:Acremonium / Q000254:growth & development*; D002511:Cephalosporins / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification; D005285:Fermentation; D006863:Hydrogen-Ion Concentration
chemical_list: D002511:Cephalosporins; C025163:cephalosporin C
vernacular_title: Biotekhnologischeskie osnovy regulirovaniia komponentnogo sostava tsefalosporinov pri kul'tivirovanii Acremonium chrysogenum.