title: The prognostic significance of resection of primary tumor in gastric and colorectal cancer patients with synchronous liver metastasis.
abstract: The significance of primary tumor resection in gastric and colorectal cancer patients with liver metastasis (H(+)) was evaluated in terms of operative mortality and survival rate by dividing the materials [293 gastric cancer and 80 colorectal cancer patients (53 colon and 27 rectum) with synchronous liver metastasis] into the following groups: Firstly, with or without peritoneal dissemination (P), secondly, with or without resection of the primary tumor and thirdly, with or without postoperative adjuvant chemotherapy. The following results were obtained: (1) The direct operative death rate of primary tumor resection, excluding death from other causes, showed an absence of statistically significant differences between the P0H(+) and P(+)H(+) gastric and colorectal cancer patients. (2) There was no significance in the prognosis between the primary tumor resection + postoperative chemotherapy group and the non-resectable group in the P(+)H(+) gastric and colorectal cancer patients, revealing no prognostic value of the primary tumor. (3) In the P0H(+) gastric and colorectal cancer patients, the primary tumor resection + postoperative chemotherapy group was significantly more favorable in prognosis than was the primary tumor resection alone group or the non-resectable group, showing the value of primary tumor resection.
authors.affiliation: Department of Surgery, School of Medicine, Chiba University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Okuyama
authors.forename: S
authors.initials: S
authors.lastname: Onoda
authors.forename: N
authors.initials: N
authors.lastname: Tohnosu
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Koide
authors.forename: A
authors.initials: A
authors.lastname: Hanaoka
authors.forename: Y
authors.initials: Y
authors.lastname: Seki
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: H
authors.initials: H
authors.lastname: Nishijima
authors.forename: K
authors.initials: K
authors.lastname: Isono
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000401:mortality / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000556:secondary; D011379:Prognosis; D012004:Rectal Neoplasms / Q000401:mortality / Q000601:surgery*; D013274:Stomach Neoplasms / Q000401:mortality / Q000601:surgery*