title: The role of the ventromedial thalamic nucleus in the catalepsy evoked from the substantia nigra pars reticulata in rats.
abstract: Picrotoxin (25, 50 and 100 ng), injected unilaterally into the posterior part of the substantia nigra pars reticulata (SNR) of rats, evoked a dose-dependent catalepsy. The catalepsy evoked by 100 ng of picrotoxin injected into the SNR was abolished by a subsequent bilateral injection of the same drug (200 ng) into the ventromedial thalamic nuclei. It is suggested that impulses pertinent to the catalepsy evoked from the SNR are transmitted via a GABAergic pathway to the ventromedial thalamic nucleus, wherefrom they reach the striatum, as had been shown previously.
authors.affiliation: Department of Neuropharmacology, Polish Academy of Sciences, Kraków.
authors.forename: W
authors.initials: W
authors.lastname: Kolasiewicz
authors.forename: S
authors.initials: S
authors.lastname: Wolfarth
authors.forename: K
authors.initials: K
authors.lastname: Ossowska
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008845:Microinjections; D010852:Picrotoxin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects / Q000503:physiopathology*; D013787:Thalamic Nuclei / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D010852:Picrotoxin