Testosterone metabolism and its testosterone-dependent activation in the uropygial gland of quail.
The in vitro metabolism in the uropygial gland of the male quail results into large yields of 5 beta-reduced and/or 17 alpha-hydroxylated metabolites. This metabolism was studied in glands of sexually quiescent quails five days after a single intra-muscular injection of testosterone to the birds. This treatment led to an increased production of inactive metabolites (epitestosterone and its 5 beta-reduced metabolites) and to a decrease of unmetabolized testosterone. Thus testosterone controls its own metabolism and by this way means to modulate its action in the uropygial gland of quail.
Floch
J Y
JY
Service de Biochimie, Faculté de Médecine, UA 598 du CNRS, Brest, France.
Morfin
R F
RF
Daniel
J Y
JY
Floch
H H
HH
D000818:Animals; D002855:Chromatography, Thin Layer; D004702:Endocrine Glands / Q000378:metabolism*; D008297:Male; D011784:Quail / Q000378:metabolism*; D012627:Sebaceous Glands / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism* / Q000494:pharmacology
D013739:Testosterone