Primary role of hyperkalemia in the acidosis of hyporeninemic hypoaldosteronism.
A 65-year-old woman with mild renal insufficiency had persistent hyperkalemia and hyperchloremic acidosis. Her plasma aldosterone level was relatively low for her hyperkalemia, and her urine pH was low. Fludrocortisone acetate administration corrected both hyperkalemia and acidosis by increasing urinary excretion of potassium and net acid, implicating deficient mineralocorticoid activity in the distal renal tubule in this patient. During this medication urinary ammonium excretion increased, but urine pH remained low, so that urinary titratable acid excretion did not decrease. On the other hand, correction of hyperkalemia by administration of a potassium-calcium exchange resin alone also resolved the acidosis by increasing urinary ammonium excretion. This increment exceeded the decrement of urinary titratable acid excretion, which was caused by raised urine pH secondary to increased urinary ammonium excretion, and resulted in increase of net acid excretion. Thus, in this patient, hyperkalemia appears to be a decisive causative factor in the acidosis, with deficient mineralocorticoid effect only contributing in part to the reduction of net acid excretion and the acidosis.
Matsuda
O
O
Second Department of Internal Medicine, Tokyo Medical and Dental University, Yushima, Japan.
Nonoguchi
H
H
Tomita
K
K
Shiigai
T
T
Ida
T
T
Shinohara
S
S
Ideura
T
T
Takeuchi
J
J
D000141:Acidosis, Renal Tubular / Q000188:drug therapy / Q000209:etiology*; D000368:Aged; D001706:Biopsy; D002411:Cation Exchange Resins / Q000494:pharmacology; D005260:Female; D005438:Fludrocortisone / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006947:Hyperkalemia / Q000150:complications* / Q000188:drug therapy; D006994:Hypoaldosteronism / Q000150:complications*; D011137:Polystyrenes / Q000494:pharmacology; D011188:Potassium / Q000652:urine; D014556:Urine / Q000032:analysis
D002411:Cation Exchange Resins; D011137:Polystyrenes; C003321:polystyrene sulfonic acid; D011188:Potassium; D005438:Fludrocortisone