title: [Clinical significance of sGOT elevation and thrombocytopenia in preeclampsia patients].
abstract: To assess the clinical significance of an elevated liver enzyme (sGOT) on the outcome of preeclamptic pregnancy, the charts of 145 preeclamptic/eclamptic patients who had sGOT determination during 7 days before and 2 days after delivery were reviewed. Of these, 60 patients exhibited a sGOT value above 30U/L (elevated sGOT group). This group was compared with the remaining 85 patients who showed a normal sGOT value related to clinical backgrounds and clinical outcome. The elevated sGOT group had a significantly low platelet count (16.4 +/- 8.4 vs. 21.4 +/- 6.7 X 10(4)/cumm, p less than 0.001) as well as a significantly high perinatal mortality rate (23.8 vs. 6.3%, p less than 0.01). There was a trend to a higher boy-to-girl ratio in the elevated sGOT group than in the normal sGOT group (1.10 vs. 0.83). In a group of 31 patients who were complicated with both elevated sGOT and thrombocytopenia, the perinatal mortality rate increased further to 42.4% and the boy-to-girl ratio was significantly higher than in the group of 66 patients who showed both a normal sGOt and normal platelet count (2.00 vs. 0.85, p less than 0.05). These results may indicate that 1) preeclamptic pregnancies complicated with liver dysfunction may tend to have a low platelet count; 2) liver dysfunction and thrombocytopenia are more likely to become complicated in preeclamptic pregnancies with a male fetus; 3) closer observations would be needed for preeclamptic pregnancy with liver dysfunction and thrombocytopenia.
authors.affiliation: Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi.
authors.forename: H
authors.initials: H
authors.lastname: Minakami
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Oka
authors.forename: T
authors.initials: T
authors.lastname: Tamada
mesh_terms: D000328:Adult; D001219:Aspartate Aminotransferases / Q000097:blood*; D005234:Fatty Liver / Q000209:etiology; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000209:etiology*; D013921:Thrombocytopenia / Q000209:etiology*
chemical_list: D001219:Aspartate Aminotransferases