Nuclear envelope reformation and chromosome decondensation are dissociable events.
Cells treated with 2,4-dinitrophenol, a metabolic inhibitor, show a strong retardation of anaphase movement. At the ultrastructural level these cells reveal nuclear envelope reformation without concurrent decondensation of the chromosomes which indicates that these are possibly two dissociable late mitotic events.
Ghosh
S
S
Institute of Cell and Tumor Biology, German Cancer Research Center, Heidelberg.
Paweletz
N
N
Armas-Portela
R
R
D019297:2,4-Dinitrophenol; D000705:Anaphase; D002875:Chromosomes / Q000378:metabolism*; D004140:Dinitrophenols / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D008938:Mitosis / Q000187:drug effects*; D009685:Nuclear Envelope / Q000378:metabolism / Q000648:ultrastructure*
D004140:Dinitrophenols; D019297:2,4-Dinitrophenol