title: tpr homologues activate met and raf.
abstract: We have previously described the primary structure of the entire met domain and part of the tpr domain present in the human tpr-met oncogene. The isolation and sequencing of an additional cDNA clone now enables us to present the complete primary sequence of the tpr domain. A computer search has unearthed a remarkable identity between tpr and a rat sequence found at the 5-prime end of the activated raf oncogene. The occurrence of tpr-like sequences in combination with two oncogenes suggests that tpr contributes a domain(s) relevant to the observed activation of met and raf.
authors.affiliation: Institute of Cancer Research, Chester Beatty Laboratories, London, UK.
authors.forename: H W
authors.initials: HW
authors.lastname: King
authors.forename: P R
authors.initials: PR
authors.lastname: Tempest
authors.forename: K R
authors.initials: KR
authors.lastname: Merrifield
authors.forename: A J
authors.initials: AJ
authors.lastname: Rance
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009857:Oncogenes; D051381:Rats
chemical_list: D004273:DNA, Neoplasm; D004247:DNA