Suppression of hepatic HMG-CoA reductase activity by beta-muricholic acid in mice fed a diet containing cholesterol and cholic acid.
A diet containing cholesterol and cholic acid (SID) is known to induce the formation of cholesterol fatty liver as well as cholesterol gallstones. The activity of HMG-CoA reductase, one of the key enzymes for cholesterol synthesis in the liver, is significantly lowered by addition of beta-muricholic acid to SID. The prevention of fatty liver formation by beta-muricholic acid was accompanied by the suppression of HMG-CoA reductase activity.
Fujino
Y
Y
Department of Pharmacology, Teikyo University School of Medicine, Tokyo, Japan.
Nakayama
K
K
Yoshimura
K
K
Furuya
Y
Y
Yonaga
T
T
D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D002793:Cholic Acids / Q000494:pharmacology*; D004032:Diet; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects
D002791:Cholesterol, Dietary; D002793:Cholic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C004821:muricholic acid; D002784:Cholesterol