[The entropic function and radioprotective effectiveness of N-substituted S-2-aminoethylthiosulfates].
Within the framework of an informational approach and the statistical method of comparison of qualitative parameters, a systemic factor is proposed, that is, the difference between entropy functions of hydrogen and carbon in the molecular structure that permits to reliably distinguish highly radioprotective agents among a series of drugs. A limiting factor (hydrophobicity) that restricts the manifestation of radioprotective properties of potential radioprotectors is considered. A relationship between toxic properties of the protective agents and their structure is discussed.
Mukhomorov
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VK
D000818:Animals; D007257:Information Theory; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship; D013816:Thermodynamics
D011837:Radiation-Protective Agents
Entropiĭnaia funktsiia i radiozashchitnaia éffektivnost' N-zameshchennykh S-2-aminoétiltiosul'fatov.