The phase-shifting effects of pentobarbital on the circadian rhythm of locomotor activity in the mouse: strain differences.
The phase response curves (PRCs) generated by pentobarbital injections (30 mg/kg) were obtained in SK and C57BL mice. Pentobarbital injections induced both advance and delay phase-shifts in the circadian rhythm of locomotor activity in SK mice but no phase-shifts were observed at any circadian time (CT) for pentobarbital injections in C57BL mice. The observation that a higher dose of pentobarbital (80 mg/kg) does not induce phase-shifting in C57BL mice has indicated that the differences in phase-shifting effects of pentobarbital are not quantitative but qualitative. These strains may be useful for studying the neurochemical regulation of the mammalian circadian rhythm.
Ebihara
S
S
Department of Animal Physiology, Faculty of Agriculture, Nagoya University, Japan.
Goto
M
M
Oshima
I
I
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D010424:Pentobarbital / Q000494:pharmacology*; D013045:Species Specificity
D010424:Pentobarbital