[Morphological study of the damaging effect of an EB vaccine strain of the plague microbe in inbred mice].
The data obtained during the study of the morphological changes in the internal organs and blood of 6 mouse strains at the early stages of anti-plague immunity are presented. It has been established that the introduction of 5.10(3) and 1.10(5) m. b. of the EV vaccine strain resulted in the development of morphological changes typical of residual virulence. The degree of these changes depended on the haplotype of the animals and the dose used. The most resistant to injury induced by EV strain were CBA mice (haplotype H-2k) and the most sensitive were C57BL/6 mice (haplotype H-2b).
Nazarova
L S
LS
Isupov
I V
IV
Pavlova
L P
LP
Gor'kova
A V
AV
Dushkin
V A
VA
D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D006239:Haplotypes; D008099:Liver / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D010931:Plague Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D013154:Spleen / Q000473:pathology; D015010:Yersinia pestis / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity
D010931:Plague Vaccine
Morfologicheskoe izuchenie povrezhdaiushchego deĭstviia vaktsinnogo shtamma EB chumnogo mikroba u inbrednykh mysheĭ.