Unusually large adrenal adenoma excreting unusually large amounts of androgen metabolites in urine.
A 27-yr female patient was admitted to the hospital because of secondary amenorrhea and a severe and complex virilization syndrome. The urinary 17-Ks, 17 OHCS and testosterone glucuronide values were greatly increased. The plasma testosterone through very high, was within the normal limits in males (3.52 ng/ml). Urography, echography and CT scan revealed a large right adrenal tumor. Removal of the tumor brought about a considerable clinical improvement: reoccurrence of the menstrual cycle, a progressive decrease in the virilization syndrome and normalization of the urinary 17-Ks, 17-OHCS and of the plasma testosterone.
Marinescu
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C. I. Parhon, Institute of Endocrinology, Bucharest, Romania.
Tache
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Zimel
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A
Mogoş
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I
D015065:17-Hydroxycorticosteroids / Q000652:urine*; D015068:17-Ketosteroids / Q000652:urine*; D000236:Adenoma / Q000473:pathology / Q000652:urine*; D000306:Adrenal Cortex Neoplasms / Q000473:pathology / Q000652:urine*; D000328:Adult; D005260:Female; D006801:Humans; D013739:Testosterone / Q000031:analogs & derivatives* / Q000652:urine
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; C015529:testosterone glucuronate; D013739:Testosterone