title: Urinary excretion of p-hydroxylated methamphetamine metabolites in man. II. Effect of alcohol intake on methamphetamine metabolism.
abstract: The effect of drinking alcoholic beverages on methamphetamine metabolism was investigated in man. The subjects, 97 males and 9 females, were divided into three groups by evaluation of their urinary pH; i.e., acidic, subacidic and neutral groups. The subjects in each group were further divided into ethanol-positive subjects and ethanol-negative subjects, depending on the presence or absence of ethanol in their urine. Gas chromatographic analysis showed the urinary concentrations of methamphetamine in the ethanol-positive subjects to be higher than those in the ethanol-negative subjects in both the acidic and subacidic urinary pH groups. Liquid chromatography, on the other hand, showed the urinary concentrations of p-hydroxymethamphetamine and p-hydroxyamphetamine for the ethanol-positive subjects to be lower than those for the ethanol-negative subjects in all three groups. The relative proportions of p-hydroxylated metabolites to unchanged methamphetamine in urine, therefore, were severely reduced in the ethanol-positive subjects. These results suggest that drinking alcoholic beverages probably results in a suppression of methamphetamine metabolism in man.
authors.affiliation: Department of Legal Medicine, Kawasaki Medical School, Okayama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shimosato
mesh_terms: D000328:Adult; D000661:Amphetamine / Q000378:metabolism / Q000652:urine; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000652:urine; D010136:p-Hydroxyamphetamine / Q000652:urine
chemical_list: D000431:Ethanol; D008694:Methamphetamine; C005877:pholedrine; D000661:Amphetamine; D010136:p-Hydroxyamphetamine