Effect of acute water deprivation on renal function in rats.
The effect of acute water deprivation for 96 h on renal function was studied in male Sprague-Dawley rats. The glomerular filtration rate (GFR) and the effective renal plasma flow (ERPF) were estimated using inulin and p-amino hippuric acid (PAH), respectively, as model compounds. Acute water deprivation caused a significant decrease (44 per cent) in the GFR without altering the ERPF. These results indicate that a proper dosage adjustment may have to be made in the dehydration condition, especially for drugs whose disposition is dependent on GFR.
Prasad
P
P
Department of Pharmacodynamics, College of Pharmacy, University of Illinois, Chicago 60612.
Niazi
S
S
Jung
D
D
D000818:Animals; D001835:Body Weight; D005919:Glomerular Filtration Rate; D007444:Inulin / Q000097:blood; D007668:Kidney / Q000502:physiology*; D008297:Male; D009399:Nephrons / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation; D014868:Water Deprivation / Q000502:physiology*; D010130:p-Aminohippuric Acid / Q000097:blood / Q000652:urine
D007444:Inulin; D010130:p-Aminohippuric Acid