Treatment of uncomplicated gonorrhea with single-dose imipenem-cilastatin.
Single 500-mg intramuscular doses of imipenem-cilastatin cured 116 (95%) of 122 men and 9 of 9 women with uncomplicated gonorrhea due to beta-lactamase-negative Neisseria gonorrhoeae. Most co-existing Chlamydia trachomatis infections persisted. Imipenem-cilastatin is effective for uncomplicated gonorrhea in men but has no advantages over other available regimens.
Verdon
M S
MS
Department of Medicine, University of Washington School of Medicine, Seattle 98104.
Judson
F N
FN
Ehret
J M
JM
Root
C J
CJ
Hook
E W
EW
McCormack
W M
WM
Frances
C A
CA
Draft
K
K
Shands
J W
JW
Handsfield
H H
HH
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000150:complications / Q000188:drug therapy; D002692:Chlamydia trachomatis; D015377:Cilastatin; D000077728:Cilastatin, Imipenem Drug Combination; D003521:Cyclopropanes / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006069:Gonorrhea / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D015378:Imipenem; D007273:Injections, Intramuscular; D008297:Male; D013845:Thienamycins / Q000008:administration & dosage / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D003521:Cyclopropanes; D004338:Drug Combinations; D013845:Thienamycins; D015377:Cilastatin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination