Comparison of mucus flow rate, radiolabelled glycoprotein output and smooth muscle contraction in the ferret trachea in vitro.
1. The concentration-response curves for rate of mucus output, labelled-glycoprotein output and smooth muscle contraction in response to methacholine, phenylephrine and salbutamol were determined in the ferret trachea in vitro. 2. The potencies of methacholine and phenylephrine are both in order: smooth muscle contraction, glycoprotein output, rate of mucus output. 3. At lower concentrations methacholine is more potent than is phenylephrine on smooth muscle contraction, glycoprotein output and rate of mucus output. 4. Concentration-response curves for salbutamol show very little change in rate of mucus output but a large increase in glycoprotein output. 5. It is concluded that the glycoprotein output induced by salbutamol may come from a source different from those induced by methacholine and phenylephrine.
Kyle
H
H
Department of Physiology, St. George's Hospital Medical School, London.
Widdicombe
J G
JG
Wilffert
B
B
D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D005260:Female; D005289:Ferrets; D006023:Glycoproteins / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology; D009093:Mucus / Q000378:metabolism*; D009119:Muscle Contraction / Q000187:drug effects; D010656:Phenylephrine / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology
D006023:Glycoproteins; D008688:Methacholine Compounds; D010656:Phenylephrine; D000420:Albuterol