title: Transient drug-induced abolition of BAEPs in coma.
abstract: Combined infusion of high doses of lidocaine and thiopental in a comatose patient induced major latency and amplitude BAEP changes, which progressed to complete BAEP abolition. Responses returned to normal after drugs were discontinued. EEGs during the episodes showed long-lasting periods of activity suppression, but were never isoelectric. BAEPs are resistant to hypothermia and barbiturates, but must be interpreted cautiously in patients treated with a combination of anesthetic drugs that includes lidocaine.
authors.affiliation: EEG Department, Hôpital Neurologique, Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: García-Larrea
authors.forename: F
authors.initials: F
authors.lastname: Artru
authors.forename: O
authors.initials: O
authors.lastname: Bertrand
authors.forename: J
authors.initials: J
authors.lastname: Pernier
authors.forename: F
authors.initials: F
authors.lastname: Mauguière
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000188:drug therapy; D001933:Brain Stem / Q000503:physiopathology; D003128:Coma / Q000503:physiopathology*; D004338:Drug Combinations; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D013874:Thiopental / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D004338:Drug Combinations; D008012:Lidocaine; D013874:Thiopental