title: Actinoplanones C, D, E, F and G, new cytotoxic polycyclic xanthones from Actinoplanes sp.
abstract: Our previous finding of strong cytotoxic polycyclic xanthones, actinoplanones A (1) and B (2), in the culture broth of Actinoplanes sp. R-304 stimulated us to isolate further five new cytotoxic polycyclic xanthones which were named actinoplanones C (3), D (4), E (5), F (6) and G (7) from the broth. Actinoplanones C (3) and G (7) showed very strong cytotoxicity against HeLa cells at less than 0.00004 microgram/ml dosage (IC50). The structures of 3-7 were varieties of 1 for the N-2 and C-4 substituents. All or several actinoplanones showed strong antimicrobial activities against bacteria and the rice blast fungus. Actinoplanone A (1) was tested for cytotoxicity against various tumor cells and for inhibitory effect on HeLa cell macromolecular synthesis, and 1 exhibited strong cytotoxicity against the cells and inhibitory action on DNA synthesis.
authors.affiliation: Mitsubishi-Kasei Institute of Life Sciences, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: C
authors.initials: C
authors.lastname: Nishino
authors.forename: J
authors.initials: J
authors.lastname: Ohya
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Mikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Shiobara
authors.forename: M
authors.initials: M
authors.lastname: Kodama
mesh_terms: D000192:Actinomycetales / Q000378:metabolism*; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000096:biosynthesis; D014176:Protein Biosynthesis; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D014966:Xanthenes; C056799:actinoplanone F; C056795:actinoplanone C; C056796:actinoplanone D; C056800:actinoplanone G; C056797:actinoplanone E; D004247:DNA