title: Cold-induced free fatty acid mobilization is impaired in rats with lesions in the preoptic area.
abstract: The increase in plasma free fatty acids (FFA) induced by cold (2 h at 5 degrees C) in rats with bilateral electrolytic lesions in the preoptic area was reduced to 30% compared to sham-operated controls. Blood glucose of lesioned rats increased 35% over initial levels and remained elevated, whereas in controls it returned to initial levels after 2 h. Rectal temperature decreased 3 degrees C in lesioned rats but not in controls. These data demonstrate the participation of the preoptic area in cold-induced FFA mobilization and provide evidence for the role of this area in the integration of thermal inputs with energy-linked metabolic processes.
authors.affiliation: Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
authors.forename: C C
authors.initials: CC
authors.lastname: Coimbra
authors.forename: R H
authors.initials: RH
authors.lastname: Migliorini
mesh_terms: D000064:Acclimatization; D000818:Animals; D003080:Cold Temperature; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D008053:Lipid Mobilization; D008297:Male; D011301:Preoptic Area / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
chemical_list: D005230:Fatty Acids, Nonesterified