title: Lingual epithelium of spontaneously hypertensive rats has decreased short-circuit current in response to NaCl.
abstract: Alterations in ion transport associated with hypertension have been found in a variety of organs. We used a modified Ussing chamber to compare the NaCl dependence of the short-circuit current across the dorsal lingual epithelium in vitro from spontaneously hypertensive rats (SHR) with that from Wistar-Kyoto rats (WKY). The short-circuit current in response to mucosal NaCl was less in SHR than in WKY at hyperosmotic concentrations (above 0.15 M and up to 2.0 M). Since ion transport in the lingual epithelium has been found to play a role in early events of salt taste transduction, the attenuation in the short-circuit current in hypertensive animals may be a factor in the enhanced salt preference of SHR compared with WKY.
authors.affiliation: Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond.
authors.forename: S
authors.initials: S
authors.lastname: Mierson
authors.forename: M E
authors.initials: ME
authors.lastname: Welter
authors.forename: C
authors.initials: C
authors.lastname: Gennings
authors.forename: J A
authors.initials: JA
authors.lastname: DeSimone
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001794:Blood Pressure; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D005260:Female; D008297:Male; D009994:Osmolar Concentration; D010042:Ouabain / Q000493:pharmacokinetics; D011189:Potassium Chloride / Q000008:administration & dosage / Q000493:pharmacokinetics; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013649:Taste / Q000187:drug effects; D014059:Tongue / Q000187:drug effects / Q000378:metabolism*
chemical_list: D012965:Sodium Chloride; D010042:Ouabain; D011189:Potassium Chloride