title: Treatment of cyclophosphamide-induced hemorrhagic cystitis in five dogs.
abstract: Sterile hemorrhagic cystitis developed in 5 dogs after treatment with cyclophosphamide. Four dogs were being treated with various antineoplastic protocols, and the fifth dog had recurrent immune-mediated thrombocytopenia. In all instances, clinical signs of hematuria and stranguria persisted after cyclophosphamide administration was discontinued. Three dogs required cystotomy to remove necrotic mucosa and calculi. The other 2 dogs were treated with intravesicularly administered dimethyl sulfoxide to decrease inflammation and to inhibit fibroplasia of the bladder wall. In 4 dogs, clinical signs resolved after treatment. The fifth dog, treated surgically, continued to have intermittent urinary incontinence attributable to residual bladder wall fibrosis.
authors.affiliation: Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada.
authors.forename: E J
authors.initials: EJ
authors.lastname: Laing
authors.forename: C W
authors.initials: CW
authors.lastname: Miller
authors.forename: S M
authors.initials: SM
authors.lastname: Cochrane
mesh_terms: D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects*; D003556:Cystitis / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary*; D008297:Male
chemical_list: D003520:Cyclophosphamide