title: [20 years' use of the diphtheria-pertussis-tetanus vaccine].
abstract: Between 1966 and 1982, a triple DPT vaccine was studied in France in 1,871 infants between the ages of 3 and 5 months. The study covered tolerance and serological efficacy of two immunization schedules using 2 or 3 initial injections. Computerized analysis of the 877 complete files showed satisfactory tolerance of this association and the serological efficacy of 2 initial doses of tetanus and diphtheria vaccines. Pertussis immunization is only effective after 3 injections. The presence of maternal antibodies when the first injection is given only decreases the immune response of diphtheria vaccine.
authors.affiliation: Centre International de l'Enfance, Château de Longchamp, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Fillastre
authors.forename: N
authors.initials: N
authors.lastname: Guerin
authors.forename: N
authors.initials: N
authors.lastname: Ajjan
authors.forename: R
authors.initials: R
authors.lastname: Triau
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D004168:Diphtheria Toxoid / Q000009:adverse effects / Q000276:immunology*; D004338:Drug Combinations; D005602:France; D006801:Humans; D007223:Infant; D010567:Pertussis Vaccine / Q000009:adverse effects / Q000276:immunology*; D013745:Tetanus Toxoid / Q000009:adverse effects / Q000276:immunology*; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D004168:Diphtheria Toxoid; D004338:Drug Combinations; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid
vernacular_title: Vingt années d'utilisation du vaccin diphtérique-tétanique-coquelucheux (DTcoq).