title: Hypogonadotrophic variant of Klinefelter's syndrome. A case report.
abstract: A 16-year-old boy with 47,XXY chromosomal complement (Klinefelter's syndrome) presented with delayed puberty and apparent gonadotrophin deficiency. Despite an inadequate growth hormone response to insulin-induced hypoglycaemia and to L-dopa administration, his somatic growth was appropriate for his delay in pubertal development, increasing markedly on testosterone treatment. Patients with Klinefelter's syndrome may have abnormalities of neuro-endocrine regulation.
authors.affiliation: Department of Paediatrics and Child Health, University of Natal, Durban.
authors.forename: D F
authors.initials: DF
authors.lastname: Wittenberg
authors.forename: T
authors.initials: T
authors.lastname: Padayachi
authors.forename: R J
authors.initials: RJ
authors.lastname: Norman
mesh_terms: D000293:Adolescent; D006065:Gonadotropins, Pituitary / Q000172:deficiency*; D006801:Humans; D007713:Klinefelter Syndrome / Q000503:physiopathology*; D008297:Male; D010901:Pituitary Function Tests; D011628:Puberty, Delayed
chemical_list: D006065:Gonadotropins, Pituitary