Inhibition of passive cutaneous anaphylaxis by several histamine (H1) and serotonin antagonists in the rat.
Drugs of the pizotifen type (pizotifen, cyproheptadine), possessing high H1-antihistamine and high antiserotonin activities in animal experiments, exert potent inhibitory actions on the passive cutaneous anaphylaxis (PCA) reaction in the rat. The drug pipethiadene, a 4,9-dihydrothieno(2,3-c)-2-benzothiepin derivative also belongs to this group. Selective histamine H1-antagonists alone are unable to cause pronounced reduction of the intensity of the PCA reaction in the rat, but in local reactions induced in rats by compound 48/80, histamine H1-receptors seem to play major role.
Metys
J
J
Research Institute for Pharmacy and Biochemistry, Praha, Czechoslovakia.
Frycová
H
H
Soucek
R
R
D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology; D005260:Female; D006633:Histamine Antagonists / Q000494:pharmacology*; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology; D010918:Pizotyline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists / Q000494:pharmacology*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D006633:Histamine Antagonists; D010880:Piperidines; D012702:Serotonin Antagonists; D010918:Pizotyline; D003533:Cyproheptadine; D003189:p-Methoxy-N-methylphenethylamine; C045300:pipethiaden