PGE1 reduces collagen and glycosaminoglycan synthesis in rabbit aorta.
In 18 male rabbits the influence of PGE1 on collagen and glycosaminoglycan synthesis assessed by means of the incorporation of radiolabelled precursors has been examined. It is demonstrated that PGE1 induces a 20-30% drop both in 14C-proline and 35S incorporation into the vessel wall. These findings are in line with earlier data on the inhibition of proliferation of smooth muscle cells and a decrease in mitotic activity. The results present one piece of evidence more that PGE1 is acting as an anti-atherosclerotic agent in vivo at the vascular level. This pathomechanism, as well as the fact that this vascular effect is achieved--in an animal experiment at least--via an intravenous PGE1-application, offers new basics for the treatment of atherosclerosis in man.
Sinzinger
H
H
Atherosclerosis Research Group Vienna (ASF), Austrian Academy of Sciences.
Zidek
T
T
Rogatti
W
W
D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis*; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D008297:Male; D011392:Proline / Q000378:metabolism; D011817:Rabbits; D013455:Sulfur / Q000378:metabolism
D006025:Glycosaminoglycans; D013455:Sulfur; D003094:Collagen; D011392:Proline; D000527:Alprostadil