[Effect of modifiers of microsomal enzymes on the enzymatic denitrosation of dialkyl-N-nitrosamines].
The antioxidant butyl-hydroxytoluene has been shown to increase denitrosation of some dialkyl-N-nitrosamines by the liver microsomes of different lines of rats and to protect against diethyl-N-nitrosamine toxicity. 3-Methylcholanthrene, while decreasing denitrosation of diethyl-N-nitrosamine, increased its toxic effect. This data suggested that enzymatic denitrosation is an effective pathway for the inactivation of dialkyl-N-nitrosamines.
Arshinov
V Iu
VIu
Shuliakovskaia
T S
TS
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D009602:Nitrosamines / Q000378:metabolism* / Q000633:toxicity; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains
D009602:Nitrosamines; D002084:Butylated Hydroxytoluene; D008748:Methylcholanthrene
Vliianie modifikatorov mikrosomal'nykh fermentov na fermentativnoe denitrozirovanie dialkil-N-nitrozoaminov.