[Effect of the matrix protein of the influenza virus on oxidative phosphorylation in preparations of isolated liver mitochondria from white mice].
The effect of matrix proteins (M proteins) of influenza A/MRC-11 and B/Lee viruses on oxidative phosphorylation in preparations of isolated mitochondria of white mice liver was studied. M proteins were shown to cause disorders in the system of oxidative phosphorylation leading to reduction of the coefficient of respiratory control and amplification coefficient recorded by the polarographic method. It was also shown that an anti-influenza compound 2-(1'-aminoethyl)-bicyclo(2.2.1)heptane hydrochloride reduced the damaging effect of influenza virus A/MRC-11 M protein but had no influence on the effect on mitochondrial respiration of influenza B/Lee virus M protein.
Mazo
E L
EL
Rusiaev
V A
VA
Fedorov
A N
AN
Iaroslavtseva
N G
NG
Kharitonenkov
I G
IG
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002458:Cell Fractionation / Q000379:methods; D004305:Dose-Response Relationship, Drug; D009980:Influenza A virus / Q000472:pathogenicity*; D009981:Influenza B virus / Q000472:pathogenicity*; D051379:Mice; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D009636:Norbornanes / Q000494:pharmacology; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D014763:Viral Matrix Proteins / Q000302:isolation & purification / Q000494:pharmacology*
D000998:Antiviral Agents; D009636:Norbornanes; D014763:Viral Matrix Proteins; C034486:2-(1'-aminoethyl)bicyclo(2.2.1)heptane
Vliianie matriksnogo belka virusa grippa na okislitel'noe fosforilirovanie v preparatakh izolirovannykh mitokhondriĭ pecheni belykh mysheĭ.