[Efficacy of verapamil in mania crises].
The authors review the different studies on the use of calcium antagonists in the treatment of acute mania. They present 7 cases, of which 4 with manic-depressive psychosis and 3 with schizo-affective disorder, during acute mania as defined by DSM III criteria, treated by verapamil at the dose of 320 mg/day. Four patients improved (2 manic-depressive, 2 schizo-affective), of which one that had responded neither to haloperidol nor to clonidine, and another for which all other treatment was contra-indicated due to important side effects. Three of these patients entered into acute depressive state between the 12th and the 15th day of treatment. The two most severe (manic-depressive) cases did not respond. The role of calcium in neuron physiology and the mode of action of calcium antagonists are outlined. The authors discuss the physiopathological hypothesis of Dubovsky.
Mathis
P
P
Service de Psychiatrie, Hôpital Bicêtre, Le Kremlin-Bicêtre.
Schmitt
L
L
Moron
P
P
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000503:physiopathology; D002118:Calcium / Q000502:physiology; D002121:Calcium Channel Blockers / Q000378:metabolism; D003000:Clonidine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D014700:Verapamil / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D008094:Lithium; D014700:Verapamil; D003000:Clonidine; D002118:Calcium
Efficacité du vérapamil dans les accès maniaques.