title: Cortical perfusion assessment with 123I-isopropyl amphetamine (123I-IAMP) in normal pressure hydrocepha lus (NPH).
abstract: NPH can be reversible after cerebrospinal fluid (CSF) diversion. In the past no reliable criteria could be defined to predict the successful outcome of CSF shunting. Several authors demonstrated an increased cerebral blood flow after lumbar puncture in patients with NPH, indicating an underlying impairment of cerebral circulation autoregulation. 123I-AMP brain tomoscintigraphy was applied to 23 individuals with NPH before and after CSF drainage. Of these 23 patients, 10 underwent surgical shunting. The frontal and parietal hypoactive cortical pattern was present in NPH but not pathognomonic. Under stimulation of CSF pressure lowering, seven patients with improved outcome after shunting demonstrated an increase of cerebral perfusion in these areas, whereas a decrease of activity was found in three patients whose clinical status was unchanged after CSF diversion. This tomoscintigraphic test may be an interesting additional criterion for surgical admission.
authors.affiliation: Clinical Neurosciences Department, CHU Henri Mondor, Creteil, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Moretti
authors.forename: A
authors.initials: A
authors.lastname: Sergent
authors.forename: F
authors.initials: F
authors.lastname: Louarn
authors.forename: G
authors.initials: G
authors.lastname: Rancurel
authors.forename: M
authors.initials: M
authors.lastname: le Percq
authors.forename: R
authors.initials: R
authors.lastname: Flavigny
authors.forename: J D
authors.initials: JD
authors.lastname: Degos
authors.forename: J P
authors.initials: JP
authors.lastname: Caron
authors.forename: M
authors.initials: M
authors.lastname: le Poncin Lafitte
authors.forename: A
authors.initials: A
authors.lastname: Bardy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002557:Cerebrospinal Fluid Shunts; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging*; D006850:Hydrocephalus, Normal Pressure / Q000000981:diagnostic imaging* / Q000601:surgery; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine