title: Molecular analysis of hemoglobin H disease in Taiwan.
abstract: The molecular basis of seven Chinese patients in Taiwan with hemoglobin H disease was investigated and was found to be heterogeneous in the mutation type. They were alpha-thalassemia-1 mutation combined with hemoglobin Constant Spring, an undetermined nondeletion form of alpha-thalassemia and a deletion form of alpha-thalassemia-2 mutations. The alpha-thalassemia-1 mutation was shown to be the --SEA type I haplotype.
authors.affiliation: Department of Medical Research, Veterans General Hospital, Taipei, Taiwan, Republic of China.
authors.forename: H H
authors.initials: HH
authors.lastname: Lee
authors.forename: W F
authors.initials: WF
authors.lastname: Cheung
authors.forename: J G
authors.initials: JG
authors.lastname: Chang
authors.forename: T C
authors.initials: TC
authors.lastname: Liu
authors.forename: W Y
authors.initials: WY
authors.lastname: Leung
authors.forename: H T
authors.initials: HT
authors.lastname: Ng
authors.forename: K B
authors.initials: KB
authors.lastname: Choo
mesh_terms: D000328:Adult; D002648:Child; D004247:DNA / Q000032:analysis; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D013789:Thalassemia / Q000235:genetics*
chemical_list: D004247:DNA