[Nonsteroidal antiandrogen inhibition of testosterone metabolism in the prostate].
The effect of prolonged administration of antiandrogen flutamide (FT) on testosterone (T) metabolism in the prostate (P) of intact and castrated rats and animals receiving androgens with substitution purpose was studied. In intact animals the production of dehydrotestosterone from labeled T in vitro was decreased in 30 days by 50%. The influence of FT on 5 alpha-reductase was shown to be determined by the blockade of androgenic effects. Proceeding from the results of experiments with FT and its hydroxylated metabolite added to incubated homogenates of the prostate of intact animals it was assumed that FT hydroxylated metabolite mediated FT influence on T metabolism.
Reznikov
A G
AG
Korpacheva
T I
TI
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D046508:Culture Techniques; D005485:Flutamide / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D009919:Orchiectomy; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D013997:Time Factors
D000726:Androgen Antagonists; C014290:hydroxyflutamide; D013739:Testosterone; D005485:Flutamide
Ingibirovanie nesteroidnymi antiandrogenami metabolizma testosterona v predstatel'noĭ zheleze.