[Binding of K 1-3 and K 4 fragments of plasminogen containing lysine-binding sites with fibrinogen and its fragments].
Interaction of plasminogen K 1-3 and K 4 fragments containing lysine binding sites with fibrinogen and its fragments has been investigated. It has been established that K 1-3 fragment binds to fibrinogen and its E and DL fragments. K 4 fragment does not bind to E and DL fragments, but it interacts with fibrinogen. K 4 fragment does not interact with early fibrinogen proteolysis X2 fragment which differs from the native molecule of fibrinogen in the alpha C domain absence. The results obtained indicate that lysine binding sites located at plasminogen K 1-3 and K 4 fragments correspond to different fibrinogen molecule centres. The centre complementary to K 4 fragment lysine binding sites could be located at the fibrinogen alpha C domain.
Tret'iachenko
V G
VG
Grinenko
T V
TV
Kudinov
S A
SA
D001665:Binding Sites; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism*; D010958:Plasminogen / Q000378:metabolism*
D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; C015214:fibrinogen D fragment; C018543:fibrinogen fragment E; C018998:lysyl-plasminogen; D005340:Fibrinogen; D010958:Plasminogen
Sviazyvanie K 1-3- i K 4-fragmentov plazminogena, soderzhashchikh lizinsviazyvaiushchie uchastki, s fibrinogenom i ego fragmentami.