title: The enterohepatic circulation of perhexiline metabolites in the male Wistar rat.
abstract: 1. The biliary excretion of some perhexiline metabolites has been assessed in male Wistar rats with biliary cannulation. 2. After intragastric administration of perhexiline maleate (2 mg/kg body weight) multiple perhexiline metabolites were detected in bile. 3. When aliquots of this metabolite-laden bile were administered intraduoduodenally to further 'recipient' rats with biliary cannulation, similar metabolites were detected in the bile of these rats, but at reduced concentrations equivalent to 30-35% of those present in the bile of 'donor' rats. 4. These findings indicate that in the male Wistar rat, there may be substantial enterohepatic circulation of some perhexiline metabolites.
authors.affiliation: Department of Medicine, University of Liverpool, UK.
authors.forename: R G
authors.initials: RG
authors.lastname: Cooper
authors.forename: S A
authors.initials: SA
authors.lastname: Jenkins
authors.forename: D A
authors.initials: DA
authors.lastname: Evans
authors.forename: A H
authors.initials: AH
authors.lastname: Price
mesh_terms: D000818:Animals; D001646:Bile / Q000032:analysis; D004764:Enterohepatic Circulation; D008401:Gas Chromatography-Mass Spectrometry; D007441:Intubation, Gastrointestinal; D008297:Male; D010480:Perhexiline / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010480:Perhexiline