Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris.
The MeOH extract of Senecio vulgaris L., administered po to rats on Days 1-10 postcoitum, significantly decreased the number of normal fetuses per pregnant rat found at autopsy on Day 16. Additional experiments showed a similar activity for its hepatotoxic constituents senecionine and senecionine N-oxide, suggesting that the latter two compounds were probably responsible for the effect seen with the extract. No antifertility effects were seen in MeOH extract-treated hamsters.
Tu
Z B
ZB
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.
Konno
C
C
Soejarto
D D
DD
Waller
D P
DP
Bingel
A S
AS
Molyneux
R J
RJ
Edgar
J A
JA
Cordell
G A
GA
Fong
H H
HH
D000818:Animals; D003270:Contraceptive Agents / Q000032:analysis*; D006224:Cricetinae; D005260:Female; D008297:Male; D008647:Mesocricetus; D010947:Plants, Toxic; D011247:Pregnancy; D011763:Pyrrolizidine Alkaloids / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012674:Senecio / Q000032:analysis*
D003270:Contraceptive Agents; D011763:Pyrrolizidine Alkaloids; C056840:senecionine N-oxide; C009237:senecionine