[Studies on tryptophan metabolism in calcium oxalate urolithiasis].
In 90 patients with calcium oxalate urolithiasis an oral tryptophan-loading test with 5 g L-tryptophan was performed and the 24-hour urinary excretion of xanthurenic acid and kynurenine was measured. In 10 cases pathological deviations and an excretion pattern of tryptophan metabolites via kynurenine similar as in the hereditary vitamin-B6-dependent xanthurenic aciduria in homozygous or heterozygous from were found. Correlations between the oxalate excretion and the tryptophan metabolism do not exist. A 2-year therapy with 60 mg vitamin B6 was favourable in patients with an excretion of more than 300 mumol XA after a tryptophan load.
Grimm
U
U
Institut für Medizinische Genetik, Bereiches Medizin, Ernst-Moritz-Arndt-Universität Greifswald, DDR.
Steinhauser
I
I
Wulff
K
K
Knapp
A
A
Zschiesche
M
M
D000284:Administration, Oral; D002129:Calcium Oxalate / Q000652:urine*; D006580:Genetic Carrier Screening; D006801:Humans; D007669:Kidney Calculi / Q000235:genetics* / Q000652:urine; D011736:Pyridoxine / Q000008:administration & dosage; D014364:Tryptophan; D026681:Vitamin B 6 Deficiency / Q000235:genetics* / Q000652:urine; D014977:Xanthurenates / Q000652:urine*
D014977:Xanthurenates; D002129:Calcium Oxalate; C028330:xanthurenic acid; D014364:Tryptophan; D011736:Pyridoxine
Tryptophanstoffwechselstudien bei Calciumoxalat-Urolithiasis.