Effects of fluocinolone acetonide on mouse skin sterol metabolism and two-stage carcinogenesis.
Fluocinolone acetonide (FA) is one of the most potent synthetic glucocorticoids and is known to possess an anti-tumor promoting activity. An attempt was made to evaluate this activity by estimating tumor promoting activity. Unexpectedly, when 10 micrograms of FA was applied alone or after a single application of a subcarcinogenic dose of 3-methylcholanthrene to mouse skin, results suggested that FA itself may be a tumor promoter or a complete carcinogen. Other glucocorticoids tested, e.g. dexamethasone, hydrocortisone and prednisolone, also revealed similar effects but were less potent than FA. To verify the possibility that glucocorticoid is a complete carcinogen or a tumor promoter, a tumor incidence experiment was performed for 24 weeks. As a result it was found that FA possesses a tumor promoting activity at some dose levels but no tumor initiating activity.
Fukao
K
K
Department of Oral and Maxillofacial Surgery, Hiroshima University, School of Dentistry, Japan.
Tanimoto
Y
Y
Kayata
Y
Y
Yoshiga
K
K
Takada
K
K
Okuda
K
K
D000818:Animals; D002849:Chromatography, Gas; D004305:Dose-Response Relationship, Drug; D005446:Fluocinolone Acetonide / Q000494:pharmacology*; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D012867:Skin / Q000378:metabolism*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D013261:Sterols / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D013261:Sterols; D005446:Fluocinolone Acetonide; D008748:Methylcholanthrene; D013755:Tetradecanoylphorbol Acetate