Differential effect of vasopressin on open-field activity and passive avoidance behaviour following intracerebroventricular versus intracisternal administration in rats.
The effects of lysine8-vasopressin (LVP) on the open-field activity and passive avoidance behaviour in rats were studied following intracerebroventricular (i.c.v.) and intracisternal (c.m.) administration. Following i.c.v. administration, LVP caused a long-lasting facilitation of the passive avoidance behaviour and did not influence open-field activity. When injected into the cisterna magna, on the other hand, the same amount of LVP was without effect on the passive avoidance behaviour, while decreasing open-field activity. It is concluded that the site of injection in the cerebrospinal space might be of importance in determining the behavioural effects of neuropeptides.
Günther
O
O
Department of Pathophysiology, University Medical School, Szeged, Hungary.
Kovács
G L
GL
Szabó
G
G
Schwarzberg
H
H
Telegdy
G
G
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002946:Cisterna Magna; D005106:Exploratory Behavior / Q000187:drug effects*; D007267:Injections; D007276:Injections, Intraventricular; D008236:Lypressin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D008236:Lypressin