Pharmacology of WEB 1881-FU, a central cholinergic agent, which enhances cognition and cerebral metabolism.
The pharmacological effects of the novel compound WEB 1881 FU (4-amino-methyl-1-benzyl-pyrrolidine-2-one-fumarate) were investigated. The tests performed indicate that the compound has cytoprotective as well as metabolism and cognition enhancing and central cholinomimetic properties. The nootropic effects in all tests were more pronounced than those of piracetam, while the central cholinomimetic effects were generally weaker than those of directly acting cholinomimetic agents. However, the typical peripheral cholinergic side effects were not observed. From the results we believe that the stimulating effect of WEB 1881 FU upon the central cholinergic system is modulatory rather than direct. The combination of nootropic and cholinomimetic properties appears favorable for treatment of brain dysfunction in the elderly. Side effects are less serious than with other known cholinomimetics.
Kuhn
F J
FJ
Department of Pharmacology, Boehringer Ingelheim KG, Ingelheim/Rhein, F.R.G.
Schingnitz
G
G
Lehr
E
E
Montagna
E
E
Hinzen
H D
HD
Giachetti
A
A
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D004569:Electroencephalography; D005260:Female; D006168:Guinea Pigs; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010100:Oxygen / Q000378:metabolism; D010277:Parasympathomimetics / Q000494:pharmacology*; D010725:Phosphocreatine / Q000378:metabolism; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects
D000227:Adenine Nucleotides; D010277:Parasympathomimetics; D011760:Pyrrolidinones; D010725:Phosphocreatine; D012601:Scopolamine; D010100:Oxygen; C056640:nebracetam