title: The suitability of a combined inulin/PAH retard tablet for measuring renal functions in the conscious rat.
abstract: As a further step in the development of implantable retard systems for simultaneous delivery of inulin and PAH, a system based on Eudragit matrix retard tablet has been deviced. It should be able to release a sufficient amount of both substances to maintain constant and well measurable serum and urine concentration in the 36 hours interval between 12-48 hours p.o. The feasibility of the technique was checked by monitoring the behaviour of renal function after administration of a permanent adrenaline application, which we used as a well defined noxa.
authors.affiliation: Universitätsinstitut für Funktionelle Pathologie, Karl-Franzens-Universität Graz, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Sadjak
authors.forename: S
authors.initials: S
authors.lastname: Supanz
authors.forename: W
authors.initials: W
authors.lastname: Korsatko
authors.forename: U
authors.initials: U
authors.lastname: Erhart
authors.forename: F
authors.initials: F
authors.lastname: Muhry
mesh_terms: D000618:Aminohippuric Acids / Q000008:administration & dosage*; D000818:Animals; D003692:Delayed-Action Preparations; D005260:Female; D007444:Inulin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007677:Kidney Function Tests / Q000379:methods*; D008657:Metabolic Clearance Rate; D051381:Rats; D011919:Rats, Inbred Strains; D010130:p-Aminohippuric Acid / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000618:Aminohippuric Acids; D003692:Delayed-Action Preparations; D007444:Inulin; D010130:p-Aminohippuric Acid