title: [Specific desensitization with allergen extracts absorbed on calcium phosphate (Pasteur Institute). Clinical and biological study apropos of 107 cases].
abstract: 107 allergic patients (71 children and 36 adults) were desensitized with allergen extracts adsorbed on calcium phosphate. Patients were selected following their symptoms (asthma, rhinitis, juvenile bronchitis, pollinosis), skin tests (ID or Prick) and total or specific IgE levels (PRIST and RAST). A mean of 17 month treatment, usually with house dust and mite extracts, rarely with house dust extract alone and in 6 cases with a mixture of grass and cereal pollens. The major aim of this study was to test the immunotherapy efficiency and to compare the IgE level variations and the clinical results. The treatment was found very good in 62% of the cases, good in 28%, and negative in 10% of the cases. The mean total IgE level has decreased of 58%, and the specific IgE level has decreased in 77% of the patients. The number of patients with a RAST class O to house dust and mites has increased respectively of 23% and 24.4% after the treatment. Besides some very good cases where the IgE levels have dropped there are lew relations between the total or specific IgE antibodies and the clinical results. The tolerance of the hyposensitization treatment was judged excellent. In conclusion, the calcium phosphate absorbed allergen extracts are confirmed as efficient and safe in immunotherapy.
authors.affiliation: Institut Pasteur.
authors.forename: A
authors.initials: A
authors.lastname: Lecadet
authors.forename: M R
authors.initials: MR
authors.lastname: Ickovic
authors.forename: M
authors.initials: M
authors.lastname: Thibaudon
mesh_terms: D000293:Adolescent; D000327:Adsorption; D000328:Adult; D000485:Allergens / Q000276:immunology; D002130:Calcium Phosphates; D002648:Child; D002675:Child, Preschool; D003888:Desensitization, Immunologic / Q000379:methods*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000628:therapy*; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011852:Radioallergosorbent Test; D012882:Skin Tests
chemical_list: D000485:Allergens; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D007073:Immunoglobulin E; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous
vernacular_title: Désensibilisation spécifique à l'aide d'extraits allergéniques adsorbés sur phosphate de calcium (Institut Pasteur). Etude clinique et biologique à propos de 107 cas.