title: Acyclovir prevents reactivation of herpes simplex labialis in skiers.
abstract: To determine the effectiveness of an antiviral to prevent herpes labialis during a brief, high-risk circumstance, 147 persons with a history of sun-induced recurrences were treated prophylactically with oral acyclovir or matching placebo and were observed during their ski holidays. Five (7%) of 75 acyclovir-treated subjects developed lesions compared with 19 (26%) of 72 persons in the placebo group.
authors.affiliation: Department of Medicine, University of Utah School of Medicine, Salt Lake City 84132.
authors.forename: S L
authors.initials: SL
authors.lastname: Spruance
authors.forename: M L
authors.initials: ML
authors.lastname: Hamill
authors.forename: W S
authors.initials: WS
authors.lastname: Hoge
authors.forename: L G
authors.initials: LG
authors.lastname: Davis
authors.forename: J
authors.initials: J
authors.lastname: Mills
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000284:Administration, Oral; D000328:Adult; D003120:Colorado; D004334:Drug Administration Schedule; D005260:Female; D006560:Herpes Labialis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D011897:Random Allocation; D012008:Recurrence; D012307:Risk Factors; D012865:Skiing; D013472:Sunlight / Q000009:adverse effects; D013473:Sunscreening Agents / Q000627:therapeutic use; D014589:Utah
chemical_list: D013473:Sunscreening Agents; D000212:Acyclovir