Brain lesions induced by hypertonic saline in mice: dose and injection route and incidence of lesions.
A single injection of hypertonic saline produced brain lesions with corresponding nervous signs in mice. The lesions were most often found in the hippocampus and were characterized by degeneration and loss of pyramidal cells. They could be induced effectively by a single administration of 20 ml of 25% saline/kg orally or of 30 ml of 8.5% saline/kg intraperitoneally. This simple experimental system seems to be a useful model of central nervous system involvement.
Takeshita
M
M
Department of Biomedical Science, Faculty of Agriculture, University of Tokyo, Japan.
Doi
K
K
Mitsuoka
T
T
D000284:Administration, Oral; D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology; D004195:Disease Models, Animal; D006624:Hippocampus / Q000098:blood supply / Q000473:pathology; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009410:Nerve Degeneration; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000009:adverse effects*; D012965:Sodium Chloride / Q000009:adverse effects*
D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride