title: [A case of vulva cancer responding to the recombinant human tumor necrosis factor (PT-950)--local injection therapy].
abstract: A case of vulva cancer responding to the recombinant human tumor necrosis factor (rHu-TNF: PT-050), which had been administered to double inguinal lymph nodes, is herein reported. A 60-year-old female underwent resection of a vulva cancer following a diagnosis of condyloma acuminatum. After surgery, however, exacerbation of a residual tumor, sited on the right of the vulva, and metastasis of the double inguinal lymph nodes were uncovered. For treatment, rHu-TNF was injected in the inguinal lymph nodes at a dose of 1 x 10(6)U per injection, 2 times a week. After 8 therapeutic sessions for 4 weeks, a marked response was observed not only in swelling of the lymph nodes, into which rHu-TNF had been injected, but also in the tumor of primary focus, which received no injections. On the 32 nd day after the final injection of rHu-TNF, the tumor of primary focus completely disappeared and the swelling of lymph nodes had diminished to 25% of the initial volume.
authors.affiliation: Dept. of Internal Medicine, Kobe National Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Irie
authors.forename: K
authors.initials: K
authors.lastname: Satonaka
authors.forename: M
authors.initials: M
authors.lastname: Matsuura
authors.forename: Y
authors.initials: Y
authors.lastname: Miura
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
mesh_terms: D003218:Condylomata Acuminata / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007272:Injections, Intralymphatic; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D012074:Remission Induction; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage* / Q000627:therapeutic use; D014846:Vulvar Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha