Radioimmunoimaging in malignant melanoma with monoclonal antibodies.
Twenty-five patients with cutaneous melanoma were imaged with F(ab')2 fragments of antimelanoma monoclonal antibody (MoAb) 225.28S labeled with 99mTc and 131I or 111In. Out of 16 patients without evidence of metastatic lesions, 6 false-positive cases were observed. Only 4 out of 9 patients with known lesions showed positive findings (globally 8 of 19 metastatic sites). In conclusion, antimelanoma MoAb was of little help in radioimaging and stating this disease.
Repetto
L
L
Divisione Oncologica Medica, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italia.
Scopinaro
G
G
Michelotti
A
A
Claudiani
F
F
Fusco
V
V
Grimaldi
A
A
Sertoli
M R
MR
Rosso
R
R
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D006801:Humans; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000276:immunology; D058950:Melanoma-Specific Antigens; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000032:analysis*; D011877:Radionuclide Imaging
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins