[Evaluation of the tolerance of the intra-ocular injection of hydroxypropyl methylcellulose in animal experiments].
Hydroxy-propyl-methyl-cellulose (HPMC) was injected into the anterior chambers or vitreous bodies of rabbit eyes in order to test local and systemic tolerance. In doing so the typical intraoperative complication of capsule rupture, which, in anterior segment surgery in man, allows HPMC to enter the vitreous body, was simulated. Neither clinically, nor in laboratory workup, nor histopathologically could any difference be shown between the local and systemic reactions of HPMC and those of DRSS. The data obtained in the study admit the conclusion that HPMC can be used in surgery of the anterior segment without any risk of adverse reactions.
Robert
Y
Y
Univ.-Augenklinik Basel.
Gloor
B
B
Wachsmuth
E D
ED
Herbst
M
M
D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects; D003228:Conjunctiva / Q000187:drug effects; D003315:Cornea / Q000187:drug effects; D005123:Eye / Q000187:drug effects*; D065347:Hypromellose Derivatives; D007267:Injections; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000633:toxicity; D011817:Rabbits; D012160:Retina / Q000187:drug effects; D014822:Vitreous Body / Q000187:drug effects
D065347:Hypromellose Derivatives; D008747:Methylcellulose
Die Uberprüfung der Verträglichkeit von intraokular injizierter Hydroxy-propyl-methyl-cellulose (HPMC) im Tierversuch.