Efficacy of antithrombin III in endotoxin-induced disseminated intravascular coagulation.
Antithrombin III (AT III) is a major modulator of the clotting cascade and is decreased in disseminated intravascular coagulation (DIC). AT III was given as a pretreatment to dogs with endotoxin-induced DIC. Significant improvement in clotting parameters (prothrombin time, fibrinogen, fibrin degradation products) was noted. There was no effect on platelets. Mean arterial blood pressure was improved, while there were no other significant changes in other measured hemodynamic, acid-base, or biochemical variables. It was concluded that AT III was effective in ameliorating endotoxin-induced changes in the clotting profile. AT III may prove to be a beneficial therapy in acquired DIC.
Hauptman
J G
JG
Department of Small Animal Clinical Sciences, Michigan State University, East Lansing 48824.
Hassouna
H I
HI
Bell
T G
TG
Penner
J A
JA
Emerson
T E
TE
D000704:Analysis of Variance; D000818:Animals; D000990:Antithrombin III / Q000627:therapeutic use*; D001777:Blood Coagulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004731:Endotoxins; D005338:Fibrin Fibrinogen Degradation Products / Q000097:blood; D005340:Fibrinogen / Q000097:blood; D006439:Hemodynamics / Q000187:drug effects; D011517:Prothrombin Time; D013997:Time Factors
D004731:Endotoxins; D005338:Fibrin Fibrinogen Degradation Products; D000990:Antithrombin III; D005340:Fibrinogen