Seizures following the withdrawal of long-term treatment with mianserin.
Seizures were observed following the withdrawal of mianserin 60 mg/day for 2 years. To our knowledge, this is the first report of convulsions after suspension of an antidepressant. This phenomenon was observed in a young woman (with no history of epilepsy or other organic diseases that may induce seizures) 10 days after abrupt discontinuation of long-term treatment with mianserin.
De Leo
D
D
Dipartimento di Psichiatria e Neurologia, Università di Padova, Facoltà di Medicina.
Dalla Barba
G
G
Zanchin
G
G
D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D008803:Mianserin / Q000009:adverse effects*; D012640:Seizures / Q000209:etiology*; D013375:Substance Withdrawal Syndrome
D008803:Mianserin