The structure of Schwann cells in unmyelinated fibres. A qualitative and quantitative electron microscope study.
The structure, size and distribution of many cytoplasmic components of Schwann cells associated with unmyelinated axons in lizard thoracic spinal roots were analysed under the electron microscope. The percentages of Schwann cell cytoplasmic area occupied by the following cytoplasmic components were determined: mitochondria, Golgi apparatus, granular endoplasmic reticulum, multivesicular bodies, smooth endoplasmic reticulum, lipofuscin granules, peroxisome-like bodies, autophagic vacuoles, dense bodies and lipid droplets. A linear correlation was found between the sectional areas of the mitochondria and granular endoplasmic reticulum of the Schwann cell and both length of Schwann cell plasma membrane profile and size of the related axoplasm. The structure of Schwann cells associated with unmyelinated axons and that of Schwann cells associated with myelinated axons were compared in the same species and in the same region of the peripheral nervous system using the same fixative and the same preparation technique. Some differences were detected in the organization of the granular endoplasmic reticulum, in the presence of cilia and in the percentages of cytoplasm occupied by various components. The hypothesis that Schwann cell mitochondria and granular endoplasmic reticulum are involved in the production and storage of proteins for the plasma membrane of this cell as well as the hypothesis that these organelles are involved in the production and storage of protein metabolites which are subsequently transferred to the related axons seem applicable not only to Schwann cells associated with myelinated axons (Pannese et al., in press), but also to those associated with unmyelinated ones.
Pannese
E
E
Institute of Histology, Embryology and Neurocytology, University of Milan, Italy.
Rigamonti
L
L
Procacci
P
P
Ledda
M
M
Arcidiacono
G
G
Frattola
D
D
D000818:Animals; D008116:Lizards; D008854:Microscopy, Electron / Q000379:methods*; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D012583:Schwann Cells / Q000648:ultrastructure*; D013126:Spinal Nerve Roots / Q000648:ultrastructure