title: [A case of advanced breast cancer successfully treated with combined tamoxifen and epitiostanol].
abstract: A patient with stage IV advanced breast cancer with multiple metastasis (bones of the whole body, lungs) were treated by ovariectomy, administration of an non-steroidal antiestrogen (tamoxifen) and mild chemotherapeutic drugs, with favorable results. After four years, however, the patient had a relapse of the cancer. A steroidal antiestrogen (epitiostanol) was then administered with satisfactory results. When a breast cancer relapse occurs in patients once treated successfully with endocrinotherapy, a different form of endocrinotherapy should be tried. There is a possibility that the mechanism of action of Epitiostanol, which is regarded as a steroidal antiestrogen, is different from that of tamoxifen in which an estrogen receptor (ER) system is included.
authors.affiliation: 2nd Dept. of Surgery, School of Medicine, University of Tokushima.
authors.forename: Y
authors.initials: Y
authors.lastname: Konishi
authors.forename: T
authors.initials: T
authors.lastname: Morimoto
authors.forename: K
authors.initials: K
authors.lastname: Komaki
authors.forename: T
authors.initials: T
authors.lastname: Yamakawa
authors.forename: N
authors.initials: N
authors.lastname: Mituyama
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Oomine
authors.forename: Y
authors.initials: Y
authors.lastname: Monden
mesh_terms: D000732:Androstanols / Q000008:administration & dosage* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D004965:Estrogen Antagonists / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D010052:Ovariectomy; D013629:Tamoxifen / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D000732:Androstanols; D004965:Estrogen Antagonists; D013629:Tamoxifen; C002976:epitiostanol