title: [Serum, synovial and intra-articular pharmacokinetics of naproxen after one-gram oral administration in patients with rheumatoid polyarthritis].
abstract: After a reminder of the major points of the pharmacokinetics of non-steroid anti-inflammatory drugs, the authors report the results of a multicentric study of the kinetics of naproxen after oral intake of one single dose of 1 gram in patients with rheumatoid arthritis. The half-life is longer in the synovial fluid than in the serum, 23 hours versus 17 hours. The balance point is obtained at the 24th hour and, at that time, the naproxen level in the synovium and the joint fluid are 32 and 60 p. cent, respectively, of the corresponding maximum concentrations.
authors.affiliation: Clinique de Rhumatologie, CHRU d'Angers.
authors.forename: J C
authors.initials: JC
authors.lastname: Renier
authors.forename: C
authors.initials: C
authors.lastname: Masson
authors.forename: F
authors.initials: F
authors.lastname: Baudel
authors.forename: M
authors.initials: M
authors.lastname: Bouvier
authors.forename: B
authors.initials: B
authors.lastname: Delcambre
authors.forename: B
authors.initials: B
authors.lastname: Fournié
authors.forename: A
authors.initials: A
authors.lastname: Heraud
authors.forename: B
authors.initials: B
authors.lastname: Hercelin
authors.forename: L
authors.initials: L
authors.lastname: Jube
authors.forename: C
authors.initials: C
authors.lastname: Menkes
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007596:Joints / Q000378:metabolism; D008875:Middle Aged; D009288:Naproxen / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013582:Synovial Fluid / Q000378:metabolism
chemical_list: D009288:Naproxen
vernacular_title: Pharmacocinétique plasmatique, synoviale et intra-articulaire du naproxène après administration orale d'un gramme chez des sujets atteints de polyarthrite rhumatoïde.