[Quantitative evaluation of the effectiveness of exposure of the joints to 239Pu and tributyl phosphate by the degree of leukopenia in rats].
The efficiency of the combined effect of 239Pu and tributyl phosphate was estimated by the severity of leucopenia in Wistar rats using the regression method and comparing the value of the actual change with the expected one. It was shown that the additive effect of the two agents delivered simultaneously was only exceeded when their doses were the largest that is, approximate the acute levels. With levels ranging from subacute effective to minimum effective ones the additivity diminished.
Kalmykova
Z I
ZI
Chudin
V A
VA
Men'shikh
Z S
ZS
D000280:Administration, Inhalation; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007958:Leukocyte Count / Q000187:drug effects / Q000528:radiation effects; D007970:Leukopenia / Q000097:blood / Q000209:etiology*; D010755:Organophosphates / Q000633:toxicity*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D011005:Plutonium / Q000009:adverse effects*; D051381:Rats; D012044:Regression Analysis; D013997:Time Factors
D010755:Organophosphates; D009943:Organophosphorus Compounds; D011005:Plutonium; C009524:tributyl phosphate
Kolichestvennaia otsenka éffektivnosti sovmestnogo vozdeĭstviia 239Pu i tributilfosfata po stepeni leĭkopenii u krys.