Towards a molecular mechanism for the crossbridge cycle.
Present evidence on crossbridge behaviour is reviewed from the viewpoint of the Eisenberg-Hill concepts. We conclude that a cartoon illustrating the operation of these ideas in practice should be drawn so as to include morphological changes in the body of the myosin molecule as part of the power-stroke. The bulk of structural evidence on the operation of crossbridges in intact muscle supports such a description.
Wray
J S
JS
Abteilung Biophysik, Max-Planck-Institut für Medizinische Forschung, Heidelberg, F.R.G.
Goody
R S
RS
Holmes
K C
KC
D000818:Animals; D008954:Models, Biological; D009119:Muscle Contraction; D009132:Muscles / Q000502:physiology*; D009210:Myofibrils / Q000502:physiology; D009218:Myosins / Q000502:physiology*
D009218:Myosins