Auto-anti-Jka in Evans' syndrome with negative direct antiglobulin test.
A patient presented with haemolytic anaemia and a negative direct antiglobulin test (DAT), and was found to have an IgG antibody with anti-Jka specificity in his serum. His red cells were typed as Jk(a-b+). Later he developed idiopathic thrombocytopenic purpura (ITP), and had a positive DAT due to anti-Jka bound to his red cells, which now typed as Jk(a+b+). Family studies suggested that the patient's true type was Jk(a+b+). Splenectomy and immunosuppression were required to treat the thrombocytopenia. The autoanti-Jka was no longer detectable following therapy.
Ganly
P S
PS
Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Laffan
M A
MA
Owen
I
I
Hows
J M
JM
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000276:immunology* / Q000628:therapy; D001789:Blood Group Antigens / Q000276:immunology*; D003298:Coombs Test; D006801:Humans; D007667:Kidd Blood-Group System / Q000276:immunology*; D008297:Male; D011696:Purpura, Thrombocytopenic / Q000276:immunology / Q000628:therapy; D013577:Syndrome
D001789:Blood Group Antigens; D007667:Kidd Blood-Group System