Differential splicing in the 3' non-coding region of rat cytochrome P-452 (P450 IVA1) mRNA.
The gene coding for the clofibrate-induced cytochrome P-452 has been isolated from a cDNA library and a full-length cDNA clone sequenced. The sequence was identical with that reported by Hardwick et al. [(1987) J. Biol. Chem. 262, 801-810] apart from the presence of an additional 75 nucleotides inserted adjacent to the 3'-end of the coding region. Northern blot analysis indicates that this is probably a consequence of differential splicing, which may be relevant to the tissue-specific regulation of this gene.
Earnshaw
D
D
Department of Biochemistry, University of Surrey, Guildford, England.
Dale
J W
JW
Goldfarb
P S
PS
Gibson
G G
GG
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002994:Clofibrate / Q000494:pharmacology; D003580:Cytochromes / Q000235:genetics*; D005786:Gene Expression Regulation; D006860:Hydrogen Bonding; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics*; D051381:Rats
D003580:Cytochromes; D012333:RNA, Messenger; C046362:cytochrome P-452; D002994:Clofibrate