Regression of ocular melanoma metastatic to the liver after hepatic arterial chemoembolization with cisplatin and polyvinyl sponge.
Thirty patients with ocular melanoma metastatic to the liver were treated by hepatic arterial chemoembolization using an admixture of cisplatin and polyvinyl sponge. Tumor regression was complete in one patient and partial (greater than 50%) in 13 patients. The total response rate was 46%. The median survival for the entire group was 11 months (95% confidence interval, nine to 18 months). Treatment-related morbidity was short-lived and included primarily severe upper right quadrant abdominal pain, transient paralytic ileus, and nonicteric hepatitis. Hepatic arterial chemoembolization provided effective palliation, with good-quality survival among 46% of patients with ocular melanoma metastatic to the liver.
Mavligit
G M
GM
Division of Medicine, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Charnsangavej
C
C
Carrasco
C H
CH
Patt
Y Z
YZ
Benjamin
R S
RS
Wallace
S
S
D000328:Adult; D000368:Aged; D002830:Choroid Neoplasms; D002945:Cisplatin / Q000494:pharmacology*; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D008545:Melanoma / Q000556:secondary / Q000628:therapy*; D008875:Middle Aged; D011145:Polyvinyls; D012074:Remission Induction
D011145:Polyvinyls; C026699:ivalon sponge; D002945:Cisplatin