The effects of probucol on QT/QS2 relation and systolic time intervals.
The QT, QTc, QS2 intervals, pre-ejection period-left ventricular ejection time ratios and serum lipoprotein levels were measured in 8 patients with primary hypercholesterolemia before and after a 3-month therapy with probucol, 1 g/day. Both QT and QTc intervals increased significantly, whereas no significant changes were observed between the pre- and post-treatment QT/QS2 and pre-ejection period-left ventricular ejection time ratios. These results help to explain why treatment with probucol, while effecting a prolongation of the QTc interval, does not result in serious arrhythmias in man.
Romics
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3rd Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
Littmann
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László
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Fenyvesi
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D000328:Adult; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D002302:Cardiac Output / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008074:Lipoproteins / Q000097:blood; D008133:Long QT Syndrome / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D010636:Phenols / Q000009:adverse effects*; D011341:Probucol / Q000009:adverse effects* / Q000627:therapeutic use; D013599:Systole / Q000187:drug effects*
D008074:Lipoproteins; D010636:Phenols; D002784:Cholesterol; D011341:Probucol