title: Insulin-like growth factor I levels in proportionate dogs, chondrodystrophic dogs and in giant dogs.
abstract: Plasma insulin-like growth factor I concentrations from proportionate, chondrodystrophic and giant breeds were evaluated and compared with body size. IGF-I plasma concentrations were 91.2 +/- 10.9 micrograms/l in Keeshounds (proportionate dog), 122.6 +/- 25.4 micrograms/l in Bassethounds (chondrodystrophic dog) and 280 +/- 22.8 micrograms/l in German Shepherds (proportionate dog). The highest IGF-I level (389.6 +/- 24.2 micrograms/l) was found in the New Foundland, a giant breed (mean +/- SEM). The mean body weight was 11.8 +/- 0.4 kg in Keeshounds, 15.4 +/- 1.4 kg in Bassethounds, 32 +/- 1.5 kg in German Shepherds, and 45.6 +/- 1.7 kg in New Foundlands (mean +/- SEM). Body weight and plasma IGF-I concentration were significantly correlated (y (IGF-I) = -7.43 + 8.7 X (body weight); P less than 0.0001.
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia.
authors.forename: J E
authors.initials: JE
authors.lastname: Eigenmann
authors.forename: A
authors.initials: A
authors.lastname: Amador
authors.forename: D F
authors.initials: DF
authors.lastname: Patterson
mesh_terms: D000818:Animals; D001827:Body Height; D001835:Body Weight; D002356:Cartilage / Q000002:abnormalities*; D004285:Dogs / Q000097:blood* / Q000235:genetics; D007334:Insulin-Like Growth Factor I / Q000097:blood*; D013002:Somatomedins / Q000097:blood*; D013045:Species Specificity
chemical_list: D013002:Somatomedins; D007334:Insulin-Like Growth Factor I