[The biotransformation of propiverin hydrochloride (Mictonorm)].
Propiverine hydrochloride [1; hydrochloride of O-n-Propyl-(N-methylpiperidinyl-4)-benzilate; Mictonorm] is metabolized after p.o. application of 25 mg/kg on rats almost completely. Besides of small amounts of unchanged 1 in urine were detected the phase-I metabolites N-methylpiperidinyl(4)-benzilate (2), 2,2-diphenyl-5-methyl-1, 4-dioxan-3-on (3), N-oxide of 2 (4), benzilic acid (5) and O-n-propylbenzilic acid (6) using ms, dc and hplc comparison of the isolated compounds with authentic samples. The structure of further metabolites, i.e. monohydroxy-benzophenone (7), acetoxy-1-derivatives (8) and ethylbenzilate (9) were elucidated by high resolution MS.
Göber
B
B
Sektion Chemie-Wissenschaftsbereich Pharmazie-der Humboldt-Universität zu Berlin.
Dressler
K
K
Franke
P
P
D000818:Animals; D001561:Benzilates / Q000493:pharmacokinetics*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D066298:In Vitro Techniques; D008297:Male; D013058:Mass Spectrometry; D010276:Parasympatholytics / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains
D001561:Benzilates; D010276:Parasympatholytics; C015586:propiverine
Zur Biotransformation von Propiverinhydrochlorid (Mictonorm) bei der Ratte.