Uric acid renal handling: spontaneous changes and influence of a thiazide alone or associated with triamterene.
The spontaneous changes in renal handling of uric acid, the consequences of methyclothiazide (M) and of a combination of M with three doses of triamterene (25, 50, 75 mg) were assessed in eight normal men, in a ten-week placebo controlled, double-blind study. In untreated subjects, significant correlations were found between blood uric acid (bUA) and UAV, between bUA and FeUA, between FeUA and plasma renin activity (PRA) and between bUA and PRA. Spontaneous variations in bUA and UAV were shown to be predominantly dependent on changes in sodium status. All diuretics significantly increased bUA and decreased FeUA. Under diuretics, bUA kept correlations with FeUA and PRA similar to that observed in untreated subjects indicating that the changes were dependent only on variations in renal transport induced by changes in sodium status. Addition of triamterene to methyclothiazide significantly lessened the thiazide induced abnormalities in UA.
Labeeuw
M
M
Department of Nephrology, INSERM U 80, CNRS UA 177, Université C. Bernard, Lyon, France.
Pozet
N
N
Aissa
A H
AH
Zech
P Y
PY
Sassard
J
J
Laville
M
M
D000328:Adult; D004232:Diuretics; D004311:Double-Blind Method; D004347:Drug Interactions; D006801:Humans; D008297:Male; D008736:Methyclothiazide / Q000494:pharmacology*; D012964:Sodium / Q000652:urine; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology*; D014527:Uric Acid / Q000652:urine*
D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D014527:Uric Acid; D012964:Sodium; D008736:Methyclothiazide