Hepatic cytochrome P450-mediated oxidation function in migraine.
Hepatic cytochrome P450-dependent oxidation is deficient in 5% to 10% of the Caucasian population. A similar percentage seems to suffer from migraine. The hypothesis was tested that an oxidation deficiency possibly relevant to potential dietary triggers plays a role in the pathogenesis of migraine. In 37 migraine sufferers and 26 controls age- and sex-matched to 26 of these patients, debrisoquine hydroxylation following an oral dose of 10 mg was employed as a marker of oxidation status, determined by calculating the metabolic ratio (MR): urinary debrisoquine/urinary 4-hydroxydebrisoquine. MR was similarly distributed in migraineurs and controls. Three subjects in each group were poor metabolizers (MR greater than 30, versus normal range, 0.1-12). MR in patients did not depend on type of migraine (common versus classic), attack frequency, the presence of trigger factors, smoking or a history of adverse reactions or sensitivity to medicines.
Amery
W K
WK
Janssen Pharmaceutica N.V., Beerse, Belgium.
Davies
P T
PT
Caers
L I
LI
Heykants
J
J
Steiner
T J
TJ
Woestenborghs
R
R
Rose
F C
FC
D000328:Adult; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000378:metabolism / Q000652:urine; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000201:enzymology / Q000209:etiology / Q000378:metabolism*; D010084:Oxidation-Reduction
C012359:4-hydroxydebrisoquin; D003577:Cytochrome P-450 Enzyme System; D003647:Debrisoquin