Effects of xylazine and acepromazine on bronchomotor tone of anaesthetised ponies.
The effects of xylazine (an alpha 2-adrenoceptor agonist) and acepromazine (an alpha-adrenoceptor antagonist) on bronchomotor tone were investigated in seven anaesthetised, apnoeic ponies using a computer aided forced oscillation technique, which separates changes in bronchial calibre from changes in lung volume. Both agents produced bronchodilatation and a decrease in lung volume.
Watney
G C
GC
University of Cambridge, Department of Clinical Veterinary Medicine.
Hall
L W
LW
Jordan
C
C
Nolan
A M
AM
D000075:Acepromazine / Q000494:pharmacology*; D000818:Animals; D001980:Bronchi / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006736:Horses / Q000502:physiology*; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000494:pharmacology*
D013843:Thiazines; D014991:Xylazine; D000075:Acepromazine