[Transcervical extra-amniotic induction of abortion in the 1st trimester of pregnancy with 200 micrograms of sulprostone in a hydroxyethylcellulose gel vehicle].
In 104 patients in the first trimenon termination of pregnancy was induced by the extra-amniotic instillation of sulproston prepared in a hydroxyethylcellulose jelly mixture. 89 women got a dose of 100 micrograms Sulproston, 15 a dose of 200 micrograms. In each group of patients the rate of side effects was almost the same. Apart from an average infection rate of 8% there were hardly any peri- or postoperative complications. Also the average abortion score was almost the same in both groups of patients. The average abortion induction interval using the double dose of Sulproston was 8.7 hours, just 1.5 hours shorter in duration as if a dose of only 100 micrograms Sulproston was given. The 100 micrograms dose leads to a 15% failure rate of induced abortion, whereas a 0% failure rate is found when applying a 200 micrograms dose. This advantage together with constant rates of complications and side effects makes the first trimenon termination of pregnancy by extra-amniotic instillation of 200 micrograms Sulproston prepared in a hydroxyethylcellulose jelly mixture appear more favourable than using only a 100 micrograms dose.
Yilmaztürk
A
A
Gyn.-Gebh. Abt., Kreiskrankenhaus Dannenberg, Elbe.
Schlüter
W
W
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D015232:Dinoprostone / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008875:Middle Aged; D014677:Pharmaceutical Vehicles; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011459:Prostaglandins E, Synthetic
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D014677:Pharmaceutical Vehicles; D011459:Prostaglandins E, Synthetic; C016767:sulprostone; D015232:Dinoprostone
Transzervikal-extraamniale Abortinduktion im I. Schwangerschaftstrimenon mit 200 micrograms Sulproston in Hydroxyethylzellulose-Gelzubereitung.