[2 pathways of polycyclic hydrocarbon hydroxylation in endoplasmic reticulum membranes].
The effect of pro-oxidant (ions of iron) and antioxidants (alpha-tocopherol, propylgallate) on hydroxylation of polycyclic hydrocarbon benz(a)-pyrene and the effect of hydroxylation process on lipid peroxidation have been studied. The role of allyl radicals formed in the fatty acid chains is discussed. The binding of oxygen radicals (formation of peroxy radicals) is regarded only as on of the possible reactions of the radical utilization. It is assumed that other reactions involving lipid (allyl) radicals, in particular, hydroxylation of benz(alpha)pyrene may occur in microsomal membranes.
Belevich
N P
NP
Dmitriev
L F
LF
Bautina
A L
AL
Ivanov
I I
II
D000818:Animals; D001564:Benzo(a)pyrene / Q000493:pharmacokinetics; D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000201:enzymology*; D006900:Hydroxylation; D007425:Intracellular Membranes / Q000187:drug effects / Q000201:enzymology*; D007501:Iron / Q000494:pharmacology; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010084:Oxidation-Reduction / Q000187:drug effects; D011083:Polycyclic Compounds / Q000493:pharmacokinetics*; D011435:Propyl Gallate / Q000494:pharmacology; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology
D008054:Lipid Peroxides; D011083:Polycyclic Compounds; D014810:Vitamin E; D001564:Benzo(a)pyrene; D011435:Propyl Gallate; D003577:Cytochrome P-450 Enzyme System; D007501:Iron
Dva puti gidroksilirovaniia politsiklicheskikh uglevodorodov v membranakh éndoplazmaticheskogo retikuluma.