Unstable translocation t(14;21) in a man, inherited as a t(13;14) in one of his daughters.
The transmission of a Robertsonian translocation was studied in a family after diagnosis of a t rob. (13;14) in a foetus, in the course of a prenatal diagnosis for maternal age. The father was found to be a carrier of a balanced t rob. (14;21) in mosaicism with a normal karyotype. The t rob(14;21) was inherited from the paternal grandfather. A second prenatal diagnosis, 1 year later, revealed a girl with the paternal t rob(14;21). Mitotic and germinal instability of the paternal t rob.(14;21) is discussed, with relation to the long period of drug addiction.
Siffroi
J P
JP
Service d'Histologie, Embryologie, Cytogénétique, Hotel-Dieu de Paris, France.
Viguie
F
F
Romani
F
F
D000328:Adult; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006556:Heroin Dependence; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008238:Lysergic Acid Diethylamide; D008297:Male; D008423:Maternal Age; D009030:Mosaicism; D018566:Pregnancy, High-Risk; D019966:Substance-Related Disorders; D014178:Translocation, Genetic
D008238:Lysergic Acid Diethylamide