[Effect of a stable analog of leu-enkephalin, dalargin, on the cell division of the corneal epithelium in white rats].
The effect of Leu-enkephalin analog--dalargin--on the corneal epithelium proliferation has been studied in white rats. 10 microliter dalargin per 1 kg body weight were administered intraperitoneally at 8 a.m. The mitotic index (MI), DNA synthesis cell index and label intensity (LI) were determined every 4 hours over a 24-hour period. The results obtained demonstrate that dalargin stimulates DNA synthesis in cells throughout the entire period of action. MI increased only 4, 8, 12 hours after dalargin administration. Mean daily DNA synthesis cell index and MI increased 2.1-fold and 3.1-fold, respectively after dalargin administration. It is suggested that dalargin activates the cell division processes by speeding up mitosis, shortening the premitotic period, accelerating the speed of the DNA synthesis and increasing cell proliferation pool.
Pan'kova
T D
TD
Timoshin
S S
SS
Radivoz
M I
MI
Titov
M I
MI
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D003315:Cornea / Q000166:cytology / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D008297:Male; D008940:Mitotic Index / Q000187:drug effects; D051381:Rats
D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D004247:DNA; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie stabil'nogo analoga leĭ-enkefalina--dalargina na protsessy kletochnogo deleniia épiteliia rogovitsy belykh krys.