The application of depth-pulse localized 31P NMR spectroscopy to monitor tumor metabolism and response to chemotherapy in the rat kidney.
To illustrate the spatial variations in metabolism within tumors, 31P spectral data are presented from a predefined, depth-pulse localized region of a rat kidney impregnated with Walker sarcoma cells. These data display the changes in energy metabolism during infiltration of the kidney by the tumor and during treatment of the tumor with cyclophosphamide.
Stewart
C A
CA
Department of Applied Sciences in Medicine, University of Alberta, Edmonton, Canada.
Hanstock
C C
CC
Allen
P S
PS
D000818:Animals; D002279:Carcinoma 256, Walker / Q000188:drug therapy / Q000378:metabolism; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004734:Energy Metabolism; D066298:In Vitro Techniques; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008991:Monitoring, Physiologic / Q000379:methods*; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains
D003520:Cyclophosphamide