title: Scintigraphy with In-111-labeled monoclonal antitumor antibodies: kinetics, biodistribution, and tumor detection.
abstract: The purpose of this study was to evaluate and compare the kinetics, biodistribution, and tumor-depicting properties of three intact indium-111-labeled murine monoclonal antibodies (MoAb) and to determine if use of In-111-labeled F(ab')2 fragments of one of them had advantages over its intact counterpart for immunoscintigraphy. Ten patients with prostate cancer were studied with an anti-prostatic acid phosphatase MoAb (PAY-276), with a resultant tumor detection rate of 15%. Twenty-eight patients with melanoma were studied with ZME-018, a MoAb that targets the KD-240 melanoma antigen. Forty-three percent of the known lesions were detected. Forty patients with carcinoembryonic antigen (CEA)-producing tumors were studied, 24 with intact ZCE-025, and anti-CEA MoAb, and 16 with its F(ab')2 fragment. With use of intact ZCE-025, 34% of known lesions were detected versus 83% with its F(ab')2 fragment. The distribution of each MoAb appears unique unto itself with regard to kinetics, normal tissue distribution, and response to MoAb mass.
authors.affiliation: Department of Radiology, Veterans Administration Medical Center, San Diego, CA 92161.
authors.forename: S E
authors.initials: SE
authors.lastname: Halpern
authors.forename: W
authors.initials: W
authors.lastname: Haindl
authors.forename: J
authors.initials: J
authors.lastname: Beauregard
authors.forename: P
authors.initials: P
authors.lastname: Hagan
authors.forename: M
authors.initials: M
authors.lastname: Clutter
authors.forename: D
authors.initials: D
authors.lastname: Amox
authors.forename: B
authors.initials: B
authors.lastname: Merchant
authors.forename: M
authors.initials: M
authors.lastname: Unger
authors.forename: C
authors.initials: C
authors.lastname: Mongovi
authors.forename: R
authors.initials: R
authors.lastname: Bartholomew
mesh_terms: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000276:immunology*; D002272:Carcinoembryonic Antigen / Q000276:immunology*; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007128:Immunoglobulin Fragments; D007205:Indium Radioisotopes; D007700:Kinetics; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D014018:Tissue Distribution
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D007140:Immunoglobulin Fab Fragments; D007128:Immunoglobulin Fragments; D007205:Indium Radioisotopes