Anticardiolipin antibodies in patients with primary immunodeficiency diseases.
The presence of antibodies to cardiolipin was determined (by an ELISA) in 143 patients with primary immunodeficiency diseases. Thirty (21%) had raised anticardiolipin antibody levels compared with only three in 98 age matched controls. The highest prevalence of this autoantibody was found in the Wiskott-Aldrich syndrome. Patients with selective IgA deficiency also showed a high prevalence of this autoantibody (32%), while patients with severe defects in antibody production showed a low prevalence or did not have such autoantibodies. This study provides further evidence of the association between autoimmune phenomena and primary immunodeficiency diseases.
Pascual-Salcedo
D
D
Department of Laboratory Medicine, Hospital la Paz, Madrid, Spain.
García Rodríguez
M C
MC
López Trascasa
M
M
Fontán
G
G
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D002308:Cardiolipins / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D017098:IgA Deficiency; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007223:Infant; D008875:Middle Aged
D001323:Autoantibodies; D002308:Cardiolipins