Immune cytotoxic mechanism of myocardial lesion in non-specific myocarditis and idiopathic congestive cardiomyopathy.
The immune cytotoxic mechanism of myocardial lesion was studied in 15 patients with non-specific myocarditis (NM) and in 10 patients with idiopathic congestive cardiomyopathy (ICC). In addition, 10 control patients having ischaemic heart disease (IHD) with congestive heart failure (CHF) and a control group of blood donors were examined. The following parameters were examined: anti-heart antibodies (by indirect enzyme-linked immunosorbent assay), lymphocyte sensibilization (by leucocyte migration inhibition test; the antigen used was cardiomyocyte membrane protein), and killer cells (K-cells) activity in the course of antibody-dependent cell-mediated cytotoxicity. Anti-heart antibodies were found in 73% of patients with NM, 50% patients with ICC and 33% patients with CHF. Lymphocyte sensibilization to the myocardium was found in 87% of patients with NM, and in more than half of the patients with ICC. Cardiospecific cytotoxic immune reaction was reproduced in vitro in 9 patients with NM and in 4 patients with ICC. It is assumed that an analogical mechanism of myocardial lesion functions in vivo.
Zimin YuI
Laboratory of Clinical Immunology, Central Research Laboratory of the USSR Ministry of Public Health, Moscow.
Sumarokov
A V
AV
Tereshchenko
S E
SE
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000276:immunology; D002311:Cardiomyopathy, Dilated / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000276:immunology*; D009206:Myocardium / Q000276:immunology*
D001323:Autoantibodies