Is immobility of rats in the forced swim test "behavioral despair"?
Rats were forced to swim in a cistern until sinking in order to examine the possible relationship between sinking and immobility which has been reported to reflect "behavioral despair" in the forced swim test. Rats were classified into sinking and non-sinking groups, according to the appearance of sinking behavior over a 2 hr test. The sinking rats showed significantly shorter immobility times during the first 15 min as compared to the non-sinking rats. Therefore, sinking behavior seems to be a sign of emotional behavior such as fear and/or anxiety accompanied by defecation. Discriminant analysis showed that the immobility time during the first 15 min was a prediction of sinking. These findings suggest that the rapidly induced immobility in this forced swim test reflects the possibility of floating behavior in connection with the emotional reaction.
Nishimura
H
H
Department of Pharmacology, Kurume University School of Medicine, Japan.
Tsuda
A
A
Oguchi
M
M
Ida
Y
Y
Tanaka
M
M
D000818:Animals; D001143:Arousal; D003863:Depression / Q000523:psychology*; D008297:Male; D009042:Motivation; D009043:Motor Activity; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming