Ion-pair reversed-phase thin-layer chromatography of basic drugs using sulphonic acids.
The use of sulphonic acid ion-pair reagents in the thin-layer chromatography of four basic drugs (all secondary amines) on C18-bonded silica gel, paraffin coated silica gel and silica gel itself has been investigated. Effects of the ion-pair reagents were only obtained on C18-bonded silica gel, and only then when the reagents were pre-coated onto the stationary phase. In general the largest reductions in the RF values of the test compounds occurred when sodium dodecylsulphate was coated onto the plates.
Ruane
R J
RJ
Department of Safety of Medicines, I.C.I. Pharmaceuticals Division, Macclesfield, Cheshire, U.K.
Wilson
I D
ID
D002855:Chromatography, Thin Layer; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012967:Sodium Dodecyl Sulfate; D013451:Sulfonic Acids
D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D013451:Sulfonic Acids; D012967:Sodium Dodecyl Sulfate