Continuous dopaminergic stimulation in cranial dystonia.
Meige's disease is a distressing complaint, the treatment of which often poses a challenge to the neurologist. The patient described here had blepharospasm-oromandibular dystonia, which responded transiently to oral lisuride. On three occasions, drug holidays successfully restored efficacy but thereafter further trials proved fruitless. Continuous subcutaneous lisuride administration in 0.35 mg doses per day, by means of a portable infusion pump, led to sustained improvement for 7 months. No major side effects were observed. Our findings suggest that this treatment deserves further trials.
Micheli
F
F
Department of Neurology, Hospital de Clínicas José de San Martín, University of Buenos Aires, Argentina.
Fernandez Pardal
M M
MM
Gatto
E
E
Paradiso
G
G
D004294:Domperidone / Q000627:therapeutic use*; D004421:Dystonia / Q000188:drug therapy; D004873:Ergolines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008090:Lisuride / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008538:Meige Syndrome / Q000188:drug therapy*; D008875:Middle Aged
D004873:Ergolines; D004294:Domperidone; D008090:Lisuride