Dependence of the so-called heparin availability on experimental factors.
The so-called heparin level in the plasma of patients or healthy volunteers should be determined using only those methods which correspond to the test standard used by the producer of the heparin applied or which approach the corresponding test principle. The correlation of the ex vivo findings gained through biochemical and functional methods to the physiological effect is, as far as possible, only then guaranteed when methodical influences can be excluded. The data obtained through these test series do not, however, allow a transference to the physiological effect of the corresponding heparin preparations regarding anticoagulant as well as antithrombotic efficacy.
Stemberger
A
A
Institute for Experimental Surgery, Technical University Munich, FRG.
Haas
S
S
Blümel
G
G
D001682:Biological Availability; D005343:Fibrinolytic Agents / Q000097:blood / Q000493:pharmacokinetics; D006493:Heparin / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans
D005343:Fibrinolytic Agents; D006493:Heparin