Peripheral pharmacokinetic parameters of levodopa/carbidopa and the on-off phenomenon in parkinsonian patients.
The principal peripheral pharmacokinetic parameters of the levodopa/carbidopa association were investigated in 11 healthy volunteers and in 16 patients at various stages of Parkinson disease, with and without the on-off phenomenon. After oral administration of a standard dose of drug (levodopa 250 mg + carbidopa 25 mg) the peak plasma concentrations, peak onset time and area under the curve/time proved to be similar across the groups. There was no difference in peripheral pharmacokinetics of the association between parkinsonian patients with swings in response and those without.
Rainero
I
I
Istituto di Clinica delle Malattie del Sistema Nervoso I e III Cattedra, Università di Torino.
Gilli
M
M
De Gennaro
T
T
Chiadò
I
I
Delsedime
M
M
Riccio
A
A
Bergamasco
B
B
D000367:Age Factors; D000368:Aged; D002230:Carbidopa / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007980:Levodopa / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood / Q000188:drug therapy*
D007980:Levodopa; D002230:Carbidopa