title: Trisomy 7 in chorionic villi: follow-up studies of pregnancy, normal child, and placental clonal anomalies.
abstract: Cytogenetic study of chorionic villi sampled because of advanced maternal age revealed, after overnight culture, an apparently non-mosaic trisomy 7. Amniocentesis showed exclusively normal mitoses, and the pregnancy continued normally. One hundred mitoses from cord blood of the normal newborn revealed a non-mosaic 46,XX complement. No cells with a proven trisomy 7 were found in cultures from either of two biopsies of the morphologically normal placenta, but the peripheral biopsy showed in multiple cultures an abnormal clone: 47,XX, +20, -2, -21, +t(2;21)(p13;q22). To our knowledge, this is the first case of non-mosaic trisomy 7 detected on CVS which has had follow-up studies of amniotic fluid, cord blood, and term placenta.
authors.affiliation: Institute of Medical Genetics, University Hospital, Geneva, Switzerland.
authors.forename: C D
authors.initials: CD
authors.lastname: Delozier-Blanchet
authors.forename: E
authors.initials: E
authors.lastname: Engel
authors.forename: P
authors.initials: P
authors.lastname: Extermann
authors.forename: B
authors.initials: B
authors.lastname: Pastori
mesh_terms: D000328:Adult; D001706:Biopsy; D002824:Chorionic Villi / Q000648:ultrastructure*; D002890:Chromosomes, Human, Pair 20; D002897:Chromosomes, Human, Pair 7; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007621:Karyotyping; D008938:Mitosis; D010920:Placenta / Q000648:ultrastructure*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis; D014314:Trisomy