Treatment of infantile spasms with tetrabenazine.
Twelve patients with infantile spasms and hypsarrhythmic EEGs were treated with tetrabenazine, a drug with antiserotonergic and antiadrenergic activity. Before treatment, and after 3 weeks of therapy, 24-h polygraphic/video monitoring studies were performed to determine response objectively. None of the patients showed cessation of spasms, EEG improvement, or improvement in development and social skills during treatment with tetrabenazine.
Hrachovy
R A
RA
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.
Frost
J D
JD
Glaze
D G
DG
D006801:Humans; D007223:Infant; D013036:Spasms, Infantile / Q000188:drug therapy*; D013747:Tetrabenazine / Q000627:therapeutic use*
D013747:Tetrabenazine