title: Subcellular changes and apoptosis induced by ethanol in rat liver.
abstract: The livers of rats given ethanol for 5 weeks showed marked structural alterations of hepatocytes of acinar zone 3 including mitochondrial pleomorphism, increased smooth endoplasmic reticulum and deposition of small (less than 0.5 micron) lipid droplets. In addition, apoptotic bodies involving altered parenchymal cells were frequently observed, together with prominent mononuclear infiltrates adjacent to the terminal hepatic veins. It is suggested that 'age' of liver cells may play a role in the preferential perivenular localization of early ethanol-induced liver damage.
authors.affiliation: Postgraduate School of Gastroenterology, University of Ancona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Benedetti
authors.forename: E
authors.initials: E
authors.lastname: Brunelli
authors.forename: R
authors.initials: R
authors.lastname: Risicato
authors.forename: T
authors.initials: T
authors.lastname: Cilluffo
authors.forename: A M
authors.initials: AM
authors.lastname: Jézéquel
authors.forename: F
authors.initials: F
authors.lastname: Orlandi
mesh_terms: D000818:Animals; D002470:Cell Survival; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D000431:Ethanol / Q000633:toxicity*; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D008055:Lipids; D000431:Ethanol