title: Maturation of composite ligament.
abstract: A variety of synthetic fibrillar ligaments are being developed and clinically investigated. The tissue response to the variety of polymeric fibrils is similar. The soft-tissue response to carbon fiber braid substituting for lateral collateral ligament in three human knees and for the anterior cruciate ligament in one was examined 12-42 months after surgery. An advanced stage of maturity of the composite structure was particularly evident by dense bundles of collagen in one of the collateral ligaments and in the substitute for the anterior cruciate ligament. Associated with the newly formed collagen the carbon fibril initially formed unique carbon collagen of composite structural units. Eventually, subsidence of the fibroblast response was accompanied by an increase in density and width of the collagen fibers and by a loss of the configuration of the carbon-collagen units. Even the mature collagenous structure was not comparable to the natural ligament.
authors.affiliation: Center for Implant Surgery, Haifa Medical Center (Rothschild), Technion, Israel.
authors.forename: D G
authors.initials: DG
authors.lastname: Mendes
authors.forename: M
authors.initials: M
authors.lastname: Soudry
authors.forename: M
authors.initials: M
authors.lastname: Roffman
authors.forename: J
authors.initials: J
authors.lastname: Boss
mesh_terms: D000328:Adult; D000368:Aged; D002244:Carbon; D000077482:Carbon Fiber; D003094:Collagen / Q000032:analysis; D006801:Humans; D007719:Knee Joint / Q000473:pathology / Q000601:surgery; D008023:Ligaments, Articular / Q000032:analysis / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D019736:Prostheses and Implants; D013583:Synovial Membrane / Q000473:pathology; D013997:Time Factors
chemical_list: D000077482:Carbon Fiber; D002244:Carbon; D003094:Collagen