Rapidly growing mature teratoma of the mediastinum: do sex hormones affect growth of the tumor?
The case of a 12-year-old girl with an anterior mediastinal tumor is reported. A mass grew rapidly and occupied the anterior mediastinum after menarche. Resected material was diagnosed as a mature teratoma. Both estrogen receptors and progesterone receptors were detected in the resected tissue. The titer of estrogen receptors was 2-11.3 femtomoles per milligram of protein and that of progesterone receptors was 9.5-15.7 fmol/mg protein. Based on these data, it was surmised that sex hormones may affect the growth of the tumor in this case. The change in sex hormones after menarche may have played a role in the rapid growth of this tumor.
Uyama
T
T
Second Department of Surgery, School of Medicine, University of Tokushima, Japan.
Monden
Y
Y
Harada
K
K
Kimura
S
S
Morimoto
T
T
Miura
K
K
Taniki
T
T
Tanida
N
N
D002648:Child; D004967:Estrogens / Q000097:blood*; D005260:Female; D006801:Humans; D008479:Mediastinal Neoplasms / Q000032:analysis / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D011374:Progesterone / Q000097:blood*; D011859:Radiography; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D013724:Teratoma / Q000032:analysis / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*
D004967:Estrogens; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011374:Progesterone