Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats.
Because of the relatively poor intestinal absorption of ampicillin sodium, efforts have been made to enhance ampicillin absorption by co-administration of absorption promoters. In the present study the enhancing effect of sodium decanoate on rate and extent of rectal ampicillin absorption in rats has been evaluated after rate-controlled and site-controlled delivery of aqueous solutions. Rectal absorption without enhancer was extremely low (8 +/- 7%), and the addition of 0.032 M sodium decanoate gave comparable values. However, administration in 0.16 M decanoate considerably increased ampicillin bioavailability, to 79 +/- 30%, whereas the absorption rate was not significantly affected.
Van Hoogdalem
E J
EJ
Division of Pharmacology, Sylvius Laboratories, State University of Leiden, The Netherlands.
De Boer
A G
AG
Breimer
D D
DD
D000285:Administration, Rectal; D000667:Ampicillin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000818:Animals; D003651:Decanoates / Q000008:administration & dosage*; D003652:Decanoic Acids / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D007262:Infusions, Intravenous; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003651:Decanoates; D003652:Decanoic Acids; D003692:Delayed-Action Preparations; D000667:Ampicillin