[Effect of suspensions of human thrombocytes and erythrocytes on the tonus of a perfused carotid artery in the cat].
Aggregated platelets cause vasospasm in a perfused cat carotid artery, its severity increasing at the vessel's deendothelization and indomethacin treatment. Erythrocyte hemolysate also produced vascular contraction, which however diminished abruptly at de-endothelization or indomethacin treatment. Possible release of vasodilating agents from platelets is discussed. It is suggested that erythrocytic vasoconstrictive effect may be due to both hemoglobin and erythrocyte membrane proteins. Prostacyclin, nifedipine, and their combinations in particular, are shown to be capable of suppressing the vasoconstrictive effect of platelets and hemolysate, while physiologic vasoconstrictive activity was increased in patients with essential hypertension.
Gabrielian
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Akopov
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SE
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D002339:Carotid Arteries / Q000502:physiology*; D002415:Cats; D004912:Erythrocytes / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000097:blood; D066298:In Vitro Techniques; D008875:Middle Aged; D010477:Perfusion; D014661:Vasoconstriction
Vliianie suspenziĭ trombotsitov i éritrotsitov cheloveka na tonus perfuziruemoĭ sonnoĭ arterii koshki.