[Effect of sodium sulfate on the microsomal oxidation system in the liver and the morphological status of the internal organs of the white rat].
The morphological state of the internal organs as well the changes of microsomal oxidation in liver of white rats exposed to the action of sodium sulfate in doses 200 and 600 mg per 100 g of body weight have been studied. The sodium sulfate in dose 600 mg per 100 g of body weight has been found to decrease the cytochrome P450 content, increase its inactivation rate and have an injurious effect on the membranes of hepatocytes. Sodium sulfate administration through the gastroenteric tract causes the destructive and pathological histochemical changes in liver, stomach, duodenum and small intestine. The alternative changes are expressed most of all in duodenum and small intestine.
Matkhanov
E I
EI
Lonshakova
K S
KS
Ubasheev
I O
IO
Azhunova
T A
TA
Mokhosoeva
V K
VK
D000632:Aminopyrine / Q000493:pharmacokinetics; D000814:Aniline Compounds / Q000493:pharmacokinetics; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006651:Histocytochemistry; D006900:Hydroxylation; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D013431:Sulfates / Q000494:pharmacology*; D014781:Viscera / Q000187:drug effects* / Q000473:pathology
D000814:Aniline Compounds; D013431:Sulfates; D000632:Aminopyrine; C012036:sodium sulfate; D003577:Cytochrome P-450 Enzyme System; C023650:aniline
Vliianie sul'fata natriia na sistemu mikrosomal'nogo okisleniia v pecheni i morfologicheskoe sostoianie vnutrennikh organov belykh krys.