title: Impact of hyperthermic regional perfusion therapy on cell metabolism of malignant melanoma monitored by 31P MR spectroscopy.
abstract: For the first time, the influence of hyperthermic regional perfusion therapy on tumor cell metabolism has been monitored by means of 31P MR spectroscopy. Shortly after treatment, a complete depletion of high energy phosphates, a significant increase of inorganic phosphate, phosphomono- and phosphodiester resonances and a decrease of pH have been observed. Healthy muscle tissue showed only minor effects caused by this aggressive therapy. The time course of the transient variation of phosphate metabolite concentrations is explained in the framework of a simple pathophysiological model. The results demonstrate that the imediate effect of chemotherapy on tumor tissue can be detected by 31P MRS before any clinical signs of tumor response are visible.
authors.affiliation: Strahlenklinik der Universität Heidelberg, W. Germany.
authors.forename: W
authors.initials: W
authors.lastname: Semmler
authors.forename: G
authors.initials: G
authors.lastname: Gademann
authors.forename: P
authors.initials: P
authors.lastname: Schlag
authors.forename: P
authors.initials: P
authors.lastname: Bachert-Baumann
authors.forename: H J
authors.initials: HJ
authors.lastname: Zabel
authors.forename: W J
authors.initials: WJ
authors.lastname: Lorenz
authors.forename: G
authors.initials: G
authors.lastname: von Kaick
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D010478:Chemotherapy, Cancer, Regional Perfusion; D002945:Cisplatin / Q000008:administration & dosage; D005534:Foot Diseases / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced; D009682:Magnetic Resonance Spectroscopy; D008545:Melanoma / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy*; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin; D008558:Melphalan