Hepatic circulation and hepatic oxygen consumption in alcoholic and nonalcoholic fatty liver.
The purpose of this study was to determine the differences in hepatic circulation and oxygen consumption in two groups: those with nonalcoholic obesity-related fatty live and those with alcoholic fatty liver. Although the histological degree of fatty infiltration was equal in the two groups, the delta Er569-650, as an index of the regional liver blood flow estimated by spectrophotometric method, was significantly lower in alcoholic fatty liver than in nonalcoholic fatty liver, and the in vivo hepatic oxygen consumption (VO2), also determined by hepatic reflectance spectrophotometry during peritoneoscopy, tended to be lower in alcoholic fatty liver than in nonalcoholic fatty liver. The oxygen saturation of hemoglobin in local liver blood (SO2) was, however, significantly higher in alcoholic fatty liver than in nonalcoholic fatty liver. These results suggest that an increase in oxygen extraction to maintain oxygen consumption, which was indicated by the lowering of the SO2, was not found in alcoholic fatty liver, in spite of a reduction of oxygen supply to the liver. It is concluded that the impairment of hepatic circulation and hepatic oxygen consumption was more serious in alcoholic fatty liver than in nonalcoholic fatty liver, possibly contributing to a different prognosis for the two forms of fatty liver.
Kasahara
A
A
First Department of Medicine, Osaka University Medical School, Japan.
Hayashi
N
N
Sasaki
Y
Y
Katayama
K
K
Kono
M
M
Yashima
T
T
Fusamoto
H
H
Sato
N
N
Kamada
T
T
D005235:Fatty Liver, Alcoholic / Q000503:physiopathology*; D006801:Humans; D008102:Liver Circulation; D008111:Liver Function Tests; D009765:Obesity / Q000503:physiopathology*; D010101:Oxygen Consumption