title: Effect of adenosine and pertussis vaccine on lymphocyte response in vitro to phytohemagglutinin in asthmatic and non-asthmatic subjects.
abstract: Adenosine and pertussis vaccine each significantly suppressed the in vitro lymphocyte response to phytohemagglutinin (PHA) in both asthmatic and non-asthmatic subjects. On the other hand, pertussis vaccine significantly enhanced the response of the lymphocytes treated with a lower concentration of adenosine both in asthmatic and non-asthmatic subjects. It was also shown that lymphocytes from asthmatic and non-asthmatic subjects responded similarly to the modulating effect of adenosine and/or pertussis vaccine on PHA stimulation. These data give further evidence for the complex interplay of the vaccine with endogenous adenosine.
authors.forename: M
authors.initials: M
authors.lastname: Hiratani
authors.forename: M K
authors.initials: MK
authors.lastname: McCall
authors.forename: E A
authors.initials: EA
authors.lastname: Chaperon
authors.forename: R G
authors.initials: RG
authors.lastname: Townley
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D000328:Adult; D001249:Asthma / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007108:Immune Tolerance; D008213:Lymphocyte Activation / Q000187:drug effects*; D010567:Pertussis Vaccine / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology
chemical_list: D010567:Pertussis Vaccine; D010835:Phytohemagglutinins; D000241:Adenosine