[Acadione, a new long-term treatment of rheumatoid polyarthritis].
This article summarizes the authors' experience and data from the literature regarding acadione, a medication like D-penicillamine with a thiol radical, in the treatment of rheumatoid arthritis. Two control studies versus placebo and two control trial versus D-penicillamine prove the effectiveness of the treatment and demonstrate a similar activity between 1 g of acadione and 600 mg of D-penicillamine. The side-effects of acadione are similar of those of D-penicillamine, essentially rash, toxic dermatitis, agueusia, proteinuria, which disappear upon discontinuation of the treatment. The fact that the patient exhibited a side effect with D-penicillamine, increases, the risk with acadione, but this is not systematic, which is the main advantage of this product.
Amor
B
B
Hôpital Cochin, Paris.
Mery
C
C
de Gery
A
A
D000603:Amino Acids, Sulfur / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D055598:Chemical Phenomena; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000627:therapeutic use; D008625:Tiopronin / Q000008:administration & dosage / Q000627:therapeutic use*
D000603:Amino Acids, Sulfur; D008625:Tiopronin; D010396:Penicillamine
L'acadione, un nouveau traitement de fond de la polyarthrite rhumatoïde.