Formulation and evaluation of nifedipine injection.
An attempt has been made to formulate a stable, aqueous injection of nifedipine (1) using the technique of hydrotropic solubilization. Sodium benzoate (2; 30% w/v) and sodium salicylate (3; 30% w/v) have been employed as the vehicle to prepare the injection of 1 in 1 mg/5 ml and 1 mg/2 ml concentration in either case. An accelerated stability study for 4 weeks at 8 degrees C, room temperature, 40 and 50 degrees C indicates maximum stability at 8 degrees C, suggesting the need of storage with refrigeration. Light stability study in the specially designed chamber indicates that covering the ampoules with black chart paper affords adequate stability to the 1 injection. The injections are also stable to autoclaving. Preliminary in vivo study in rats shows that the injection is effective.
Jain
N K
NK
Pharmacy Department, Faculty of Technology and Engineering, M.S. University of Baroda, India.
Patel
V V
VV
Taneja
L N
LN
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004355:Drug Stability; D005069:Evaluation Studies as Topic; D005260:Female; D008027:Light; D009543:Nifedipine / Q000008:administration & dosage* / Q000494:pharmacology; D014677:Pharmaceutical Vehicles; D051381:Rats; D012995:Solubility; D013242:Sterilization; D013696:Temperature
D014677:Pharmaceutical Vehicles; D009543:Nifedipine