[Kinetic aspects of the relation of the growth of the producer and the biosynthesis of heliomycin depending on the carbon source in the medium].
Kinetic parameters of Streptomyces olivocinereus 11-98 growth and biosynthesis of heliomycin were studied. It was shown that carbon sources such as glycerol, mannitol and ramnose were the most favourable for the antibiotic biosynthesis. These carbon sources belonged to the group of substances providing high growth rates of the culture. Ranging of the culture growth rates and antibiotic production levels revealed a set of carbon sources providing a converse relationship between the growth rate and antibiotic biosynthesis i.e. L-arabinose, potassium gluconate, raffinose and sucrose. It was suggested that these compounds were catabolic type regulators of heliomycin biosynthesis.
Deianova
O A
OA
Vinogradova
K A
KA
Polin
A N
AN
D000143:Acids / Q000494:pharmacology; D000438:Alcohols / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D002241:Carbohydrates / Q000494:pharmacology; D003470:Culture Media; D007700:Kinetics; D011083:Polycyclic Compounds / Q000096:biosynthesis*; D013302:Streptomyces / Q000187:drug effects / Q000254:growth & development*
D000143:Acids; D000438:Alcohols; D000900:Anti-Bacterial Agents; D002241:Carbohydrates; D003470:Culture Media; D011083:Polycyclic Compounds; C007912:heliomycin
Kineticheskie aspekty sootnosheniia rosta produtsenta i biosinteza geliomitsina v zavisimosti ot istochnika ugleroda v srede.