title: The role of feces, necrotic tissue, and various blocking agents in the prevention of adhesions.
abstract: Ischemic tissue and intraperitoneal bacteria have been ascribed an etiologic role in the production of intra-abdominal adhesions. To further elucidate the role of these stimuli and to evaluate the potential protective effect of various agents, peritonitis was induced in 160 Sprague-Dawley rats. The experiment was stratified into those animals with peritonitis plus necrotic tissue, solid feces, both, or neither. The agents tested were a nonsteroidal anti-inflammatory (ibuprofen), free radical scavenger (SOD), and an anticoagulant (heparin). Death was less likely to occur in animals treated with heparin (3 of 40 vs. 12 of 40, p less than 0.01) or SOD (4 of 40 vs. 12 of 40, p less than 0.05). Ibuprofen did not increase survival in this model. Heparin protected against adhesions in animals with an ischemic ileum of limb and without solid feces. In animals with a nonischemic isolated segment of ileum and solid feces, adhesion formation was increased in both the ibuprofen and the heparin treatment groups (p less than 0.05).
authors.affiliation: Department of Surgery, Baylor University Medical Center, Dallas, Texas 75246.
authors.forename: J P
authors.initials: JP
authors.lastname: O'Leary
authors.forename: G
authors.initials: G
authors.lastname: Wickbom
authors.forename: S O
authors.initials: SO
authors.lastname: Cha
authors.forename: A
authors.initials: A
authors.lastname: Wickbom
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005243:Feces; D006493:Heparin / Q000494:pharmacology; D007052:Ibuprofen / Q000494:pharmacology; D007082:Ileum / Q000473:pathology*; D008297:Male; D009336:Necrosis; D010538:Peritonitis / Q000150:complications*; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000494:pharmacology; D000267:Tissue Adhesions / Q000209:etiology* / Q000401:mortality / Q000517:prevention & control
chemical_list: D006493:Heparin; D013482:Superoxide Dismutase; D007052:Ibuprofen