Number and distribution density of ABH and MN antigen sites on young and old human erythrocyte surfaces.
There were no differences in the number of A and M antigen sites between young and old human erythrocyte surfaces. No essential differences in the number of A1, N and Vicia graminea N antigen sites could be observed between young and old erythrocytes. The number of B and H antigen sites on cell surface was significantly higher in young erythrocytes than in old ones. The distribution density of A and M antigen sites on young erythrocyte was remarkably higher than that on old ones. Compared with young erythrocytes, significant increases in the distribution density of A1, B, H, N and Vicia graminea N antigen sites were observed in aged erythrocytes. It is suggested from these and other observations that human erythrocyte aging is accompanied by elimination of a small amount of B and H antigens from cell membranes, while A, A1, M, N and Vicia graminea N antigens are not released from cell membranes during in vivo aging.
Shinozuka
T
T
Department of Legal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Takei
S
S
Yanagida
J
J
Watanabe
H
H
Ohkuma
S
S
D000017:ABO Blood-Group System; D000818:Animals; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000032:analysis*; D006801:Humans; D008951:MNSs Blood-Group System; D011817:Rabbits; D013499:Surface Properties
D000017:ABO Blood-Group System; D008951:MNSs Blood-Group System