Renal glutathione homeostasis in compensatory renal growth.
Glutathione homeostasis was investigated in unilaterally nephrectomized and sham-operated rats. Following twelve days of compensatory renal growth, it was found that the concentrations of glutathione and glutathione disulfide in representative samples of the entire remnant right kidney from the nephrectomized rats were similar to those found in corresponding samples of the right kidneys from the sham-operated rats. However, since the mass of the remnant right kidneys in the nephrectomized rats was greater than that of the right kidneys from the sham-operated rats, the absolute content of glutathione and glutathione disulfide was greater in the remnant right kidneys of the nephrectomized rats than in the right kidneys of the sham-operated rats. In general, the findings from the present study indicate that the absolute content of glutathione and glutathione disulfide in renal epithelial cells increases in proportion to the increase in mass that results from compensatory renal cellular hypertrophy.
Zalups
R K
RK
Department of Anatomy, Oral Roberts University School of Medicine, Tulsa, OK 74171.
Veltman
J C
JC
D000818:Animals; D005978:Glutathione / Q000378:metabolism*; D006706:Homeostasis; D007668:Kidney / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D009392:Nephrectomy; D051381:Rats
D005978:Glutathione