title: Nonedited 1H NMR lactate/n-acetyl aspartate ratios and the in vivo determination of lactate concentration in brain.
abstract: The 1H lactate/n-acetyl aspartate ratio is commonly used for the quantitation of brain lactate under pathological conditions. We demonstrate that the intensity of the lactate methyl region in water-suppressed, nonedited 1H spectra increases following mild brain trauma as a result of factors other than lactate accumulation.
authors.affiliation: Department of Neurology, V.A. Medical Center, San Francisco, California 94121.
authors.forename: R
authors.initials: R
authors.lastname: Vink
authors.forename: T K
authors.initials: TK
authors.lastname: McIntosh
authors.forename: A I
authors.initials: AI
authors.lastname: Faden
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007773:Lactates; D001224:Aspartic Acid; C000179:N-acetylaspartate