Fructosamine in the management of gestational diabetes.
The role of maternal serum fructosamine estimation in the management of gestational diabetes was assessed in 78 consecutive patients over a 3-year period. Fructosamine results correlated significantly with mean plasma glucose levels over a 1- to 3-week interval, with the closest association being in the preceding week. Eighty-five percent of women with gestational diabetes had peak serum fructosamine levels above the normal range. If maternal levels exceeded 3.2 mmol/L, there was an 88% chance of abnormal glucose tolerance post partum. Our aim of management was a serum fructosamine level less than 2.5 mmol/L; patients who achieved this goal by 35 to 37 weeks' gestation had fewer obese babies with lower cord insulin and C-peptide levels as compared with neonates of mothers with elevated fructosamine concentrations.
Roberts
A B
AB
Department of Obstetrics, Gynecology, and Neonatology, National Womens Hospital, Auckland, New Zealand.
Baker
J R
JR
James
A G
AG
Henley
P
P
D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005320:Fetal Macrosomia / Q000175:diagnosis; D019270:Fructosamine; D006595:Hexosamines / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D049590:Postpartum Period; D011237:Predictive Value of Tests; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood* / Q000628:therapy; D011296:Prenatal Diagnosis
D001786:Blood Glucose; D006595:Hexosamines; D019270:Fructosamine