Bioavailability in human volunteers of three intramuscular formulations of cefonicid: a long-acting cephalosporin.
Three different intramuscular formulations of cefonicid (a new long acting cephalosporin) have been tested for bioavailability in 12 healthy volunteers, using a triple crossover design. No significant differences were detectable between the bioequivalence of the three formulations in terms of area-under-curve and 24-h urinary excretion. However, one of the formulations (A) was absorbed significantly more rapidly from the site of injection, causing higher serum levels for up to 1.5 h after administration. A significantly greater urinary excretion was also found up to 8 h after administration of formulation A. All three formulations were well tolerated, and no side-effects or significant changes in laboratory tests were observed.
Brumfitt
W
W
Department of Medical Microbiology, Royal Free Hospital School of Medicine, London.
James
I
I
Hamilton-Miller
J M
JM
Grady
D
D
Price
C
C
D000328:Adult; D001682:Biological Availability; D002435:Cefamandole / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D015790:Cefonicid; D005260:Female; D006207:Half-Life; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D011897:Random Allocation
D002435:Cefamandole; D015790:Cefonicid