Surgical intensive care unit pneumonia.
With use of an objective numerical rating system for the assessment of the presence or absence of pneumonia on a chest x-ray film, 81 patients in the surgical intensive care unit with positive sputum cultures were assigned to either colonization (C; 39 patients) or pneumonia (P; 42 patients) groups. Respiratory failures preceding the first positive sputum culture and hepatic and/or renal failure were more frequent in the P group. Escherichia coli and Pseudomonas species, as well as polymicrobial sputa, were more common in the P group. Positive blood or pleural cultures with the same organism found in the sputum were noted in 10 of 11 P patients and only 3 of 10 C patients. Broad-spectrum antibiotic therapy directed at all sputum pathogens decreased mortality in the P group but not in the C group. We conclude that an objective rating system for chest x-ray diagnosis provides a reasonable method for separating patients with pneumonia from those with colonization. We recommend antibiotic therapy directed at all sputum pathogens in patients in surgical intensive care units. For such therapy to be successful, however, diagnostic criteria must be precise and exclude patients with colonized pathogens.
Mock
C N
CN
Department of Surgery, Brown University, Providence, R.I.
Burchard
K W
KW
Hasan
F
F
Reed
M
M
D001419:Bacteria / Q000302:isolation & purification; D003422:Critical Care; D003428:Cross Infection / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D005658:Fungi / Q000302:isolation & purification; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011018:Pneumonia, Pneumococcal / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000401:mortality; D011183:Postoperative Complications / Q000453:epidemiology* / Q000401:mortality; D011859:Radiography; D012237:Rhode Island; D013183:Sputum / Q000382:microbiology