title: Pharmacological analysis of the magnocellular red nucleus during classical conditioning of the rabbit nictitating membrane response.
abstract: Previous experiments have suggested that the red nucleus is an essential structure in the neural pathways subserving the conditioned responses (CRs) elicited in several simple associative learning paradigms. The present investigation confirms the involvement of the magnocellular red nucleus in production of the classically conditioned nictitating membrane response in the rabbit and suggests that gamma-aminobutyric acid (GABA) processes within this structure are involved in expression of the CR. Specifically, these studies demonstrate that microinfusion of a GABA antagonist (either picrotoxin or bicuculline methiodide) into the magnocellular red nucleus can selectively and reversibly reduce or abolish retention of the CR, without altering the unconditioned reflex response. Furthermore, these pharmacological manipulations that disrupt the CR are both anatomically and pharmacologically specific, and demonstrate a predictable dose-dependent function. These findings suggest that GABAergic processes within the magnocellular red nucleus are part of the critical circuitry subserving the CR.
authors.affiliation: Department of Psychology, Stanford University, California 94305.
authors.forename: D A
authors.initials: DA
authors.lastname: Haley
authors.forename: R F
authors.initials: RF
authors.lastname: Thompson
authors.forename: J
authors.initials: J
authors.lastname: Madden
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000031:analogs & derivatives* / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D008297:Male; D009541:Nictitating Membrane / Q000502:physiology*; D010852:Picrotoxin / Q000494:pharmacology*; D011817:Rabbits; D012012:Red Nucleus / Q000187:drug effects / Q000502:physiology*; D012153:Retention, Psychology / Q000187:drug effects; D013331:Strychnine / Q000494:pharmacology*
chemical_list: D001640:Bicuculline; D010852:Picrotoxin; D013331:Strychnine; C017069:bicuculline methiodide