C7 deficiency and persistent haematuria.
A 14-year-old boy had persistent haematuria along with complete C7 deficiency. No significant changes in glomeruli and tubules were found in a renal biopsy specimen by light microscopy and immunofluorescence gave negative results for immune deposits. Electron microscopic examination demonstrated an attenuation of the glomerular capillary basement membrane without lamination and a diagnosis of thin basement membrane disease was made. It would be difficult to conclude that patients with C7 deficiency were predisposed to develop glomerulonephritis caused by immunologic aberrations. A family study failed to provide evidence of an association of C7 deficiency and thin basement membrane disease.
Sakano
T
T
Department of Paediatrics, Hiroshima University School of Medicine, Japan.
Hamasaki
T
T
Mori
M
M
Ohta
T
T
Ueda
K
K
Ishigame
K
K
Kawamura
M
M
Takeda
N
N
D000293:Adolescent; D001485:Basement Membrane / Q000648:ultrastructure; D002196:Capillaries / Q000648:ultrastructure; D003184:Complement C7 / Q000172:deficiency* / Q000235:genetics; D005260:Female; D006417:Hematuria / Q000150:complications* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply / Q000648:ultrastructure; D008297:Male
D003184:Complement C7