[Effect of plant growth regulators, hydrazine derivatives, on the state of the microsomal systems of the liver].
Hydrazine derivatives (Gidrel, Digidrel and DMMH) at a dose of 1/10 (LD50) inhibit microsomal oxidation, decrease superoxide dismutase activity and activate lipid peroxidation in the rat hepatic microsomes. At the same dose level maleic hydrazide has no effect on the indices studied. The role of superoxide-superoxide dismutase system in the mechanism of microsomal oxidation inhibition by hydrazine derivatives is discussed.
Koshkarian
A O
AO
Kocharian
E S
ES
Aloian
G A
GA
Avakian
A Kh
AKh
D000818:Animals; D008054:Lipid Peroxides / Q000096:biosynthesis; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010084:Oxidation-Reduction; D010937:Plant Growth Regulators / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D013386:Succinates / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism
D008054:Lipid Peroxides; D009943:Organophosphorus Compounds; D010937:Plant Growth Regulators; D013386:Succinates; C025731:Hydrel; C037724:dihydrel; D013482:Superoxide Dismutase; C014499:daminozide
Vliianie reguliatorov rosta rasteniĭ--proizvodnykh gidrazina--na sostoianie mikrosomnykh sistem pecheni.