Thymidylate synthase gene of herpesvirus ateles.
The putative thymidylate synthase (TS) gene of herpesvirus ateles, a T-lymphotropic tumor virus of New World primates, has a single large open reading frame encoding a polypeptide of 32.9 kilodaltons. The gene is transcribed into an unspliced 2.4-kilobase mRNA that is abundantly expressed late in virus replication. The AT-rich 5' untranslated leader sequence of TS mRNA in herpesvirus ateles-infected cells is remarkable in length (1,184 nucleotides), containing 29 minicistrons; this may indicate a role in translation regulation.
Richter
J
J
Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, Federal Republic of Germany.
Puchtler
I
I
Fleckenstein
B
B
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005814:Genes, Viral; D006564:Herpesviridae / Q000201:enzymology / Q000235:genetics* / Q000502:physiology; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D021382:Protein Sorting Signals / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D013940:Thymidylate Synthase / Q000235:genetics*; D014158:Transcription, Genetic; D014779:Virus Replication
D021382:Protein Sorting Signals; D012333:RNA, Messenger; D012367:RNA, Viral; D013940:Thymidylate Synthase