title: Effects of short-term administration of cytidine, uridine and levoglutamine, alone or in combination, on the cerebral electrical activity of patients with chronic cerebrovascular disease.
abstract: Various data in the literature confirm that spectral analysis by an electroencephalograph (EEG) allows the evaluation and quantification of the modifications of cerebral electrical activity due to pathological events or to drugs acting on the central nervous system. Thirty patients with chronic cerebrovascular disease, selected according to the criteria established by the 1980 Paris Ad Hoc Committee were submitted to EEG analysis in basal conditions and after intravenous short-term administration of various doses of cytidine, uridine and levoglutamine given either alone or in combination. The combined administration of the three substances led to a general improvement of cerebral electrical parameters with a trend toward more physiological patterns.
authors.affiliation: Department of Neurology and Neurophysiopathology, Italian Institute of Neurotraumatology, Rome.
authors.forename: V
authors.initials: V
authors.lastname: Manna
authors.forename: N
authors.initials: N
authors.lastname: Martucci
mesh_terms: D000368:Aged; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000503:physiopathology; D003562:Cytidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D005260:Female; D005973:Glutamine / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014529:Uridine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D005973:Glutamine; D003562:Cytidine; D014529:Uridine