Renal imaging studies at 1.5 and 9.4 T: effects of diuretics.
We have studied the effects of two diuretics, selective for renal cortical (furosemide) and inner medullary (vasopressin antagonist) water handling, in rat kidney at 1.5 T and find that furosemide completely dissipates the cortical-inner medullary T2 gradient whereas the vasopressin antagonist has little effect. This phenomenon appears to be related to changes in luminal water content. We also demonstrate the feasibility of obtaining live mouse kidney images with a resolution of 100 x 100 x 700 micrometers at 9.4 T.
Sarkar
S K
SK
Department of Physical and Structural Chemistry, Smith Kline and French Laboratories, King of Prussia, Pennsylvania 19406.
Holland
G A
GA
Lenkinski
R E
RE
Mattingly
M A
MA
Kinter
L B
LB
D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology; D007668:Kidney / Q000033:anatomy & histology* / Q000187:drug effects; D007672:Kidney Cortex / Q000033:anatomy & histology / Q000187:drug effects; D007679:Kidney Medulla / Q000033:anatomy & histology / Q000187:drug effects; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D008819:Mice, Nude; D051381:Rats; D011919:Rats, Inbred Strains
D004232:Diuretics; D001127:Arginine Vasopressin; D005665:Furosemide; C050890:1-((beta-mercapto-beta)beta cyclopentamethylenepropionic acid)-2-(O-ethyl-Tyr)-4-Val-9-des-Gly-arginine vasopressin