Cisplatin ototoxicity in guinea pigs with special reference to toxic effects in the stria vascularis.
The toxic effects of cisplatin (cis-diamminedichloroplatinum [II]) on the organ of Corti are well established. Few and conflicting data on this drug's effects on the stria vascularis exist. The present study presents animal experiments on the toxic effects of cisplatin in the stria vascularis and in the organ of Corti. Cisplatin-induced toxicity in albino and pigmented guinea pigs was evaluated morphologically and functionally, using light and transmission electron microscopy as well as auditory brainstem-evoked potentials on the organ of Corti and the stria vascularis. The results showed variability in hearing thresholds, ranging from no change to hearing loss of 30 dB, and prominent damage in the organ of Corti and in the stria vascularis. The toxic effects to both the organ of Corti and the stria vascularis should be considered when cisplatin is used in chemotherapy.
Kohn
S
S
Unit of Electron Microscopy, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Fradis
M
M
Pratt
H
H
Zidan
J
J
Podoshin
L
L
Robinson
E
E
Nir
I
I
D000818:Animals; D001300:Audiometry, Evoked Response; D002945:Cisplatin / Q000633:toxicity*; D003051:Cochlea / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D006168:Guinea Pigs; D007759:Labyrinth Diseases / Q000139:chemically induced; D008854:Microscopy, Electron; D009925:Organ of Corti / Q000187:drug effects*; D013316:Stria Vascularis / Q000187:drug effects*
D002945:Cisplatin