Intestinal absorption of chloral hydrate, free trichloroethanol and trichloroacetic acid in dogs.
In order to examine the intestinal absorption of chloral hydrate (CH), free trichloroethanol (F-TCE) and trichloroacetic acid (TCA), an intestinal circulation system in dogs was developed using jejunal, ileal and colonic loops, and solutions of CH, F-TCE and TCA were circulated within them. The concentrations of these substances and their metabolites in the serum, urine, bile and circulates were then measured. In all groups, the fraction of water absorbed from the intestine was about 10% of the administered volume two hours after administration. The absorbed fraction of CH was about 50% in the jejunum and ileum, and about 40% in the colon. The absorbed fraction of F-TCE was about 60% in the jejunum, 50-60% in the ileum and about 40% in the colon, while the figures for TCA were about 40-50% in the jejunum and about 30-40% in the ileum and colon. The combined biliary and urinary excretion ratios of the administered substances and their respective metabolites to the total amounts absorbed from the intestine were about 25-30% for F-TCE, 10-15% for CH and 0.1-0.2% for TCA in all parts of the intestine two hours after administration.
Hobara
T
T
Department of Public Health, Yamaguchi University School of Medicine, Ube, Japan.
Kobayashi
H
H
Kawamoto
T
T
Iwamoto
S
S
Sakai
T
T
D000818:Animals; D002697:Chloral Hydrate / Q000493:pharmacokinetics* / Q000652:urine; D002728:Chlorohydrins / Q000493:pharmacokinetics*; D003106:Colon / Q000378:metabolism; D004285:Dogs; D005023:Ethylene Chlorohydrin / Q000031:analogs & derivatives / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D007082:Ileum / Q000378:metabolism; D007408:Intestinal Absorption; D007583:Jejunum / Q000378:metabolism; D008297:Male; D014238:Trichloroacetic Acid / Q000493:pharmacokinetics* / Q000652:urine
D002728:Chlorohydrins; D002697:Chloral Hydrate; D014238:Trichloroacetic Acid; D005023:Ethylene Chlorohydrin