title: Aldosterone in colonic potassium adaptation in rats.
abstract: The influence of adrenalectomy and administration of aldosterone on potassium secretion by colonic epithelium was studied in vivo in rats, particularly in relation to potassium adaptation (induced by feeding a potassium-rich diet) and the response to acute i.v. administration of a potassium load. Adrenalectomy (rats maintained on dexamethasone and saline) impaired the development of potassium adaptation or considerably reduced it if the rats had been previously adapted. The partial adaptation observed in the adrenalectomized rats may be related to the increased plasma potassium concentration developed when these rats received the potassium-rich diet. Within 2 h of acute aldosterone administration, the response of the potassium secretion rate to acute potassium loading in adrenalectomized rats was significantly improved. When aldosterone (2 micrograms/day per 100 g body weight, given by osmotic minipump) was added to the replacement treatment, the plasma concentration of potassium was similar to that of the intact rats, and both potassium adaptation and the response to the acute potassium load were completely restored. Transepithelial potential difference and sodium transport were not stimulated, being similar to the values in intact rats. Considerable changes in potassium secretion induced by acute potassium loading did not significantly affect sodium transport. The findings suggest that the sodium and potassium epithelial pathways are, to a large extent, independently influenced by aldosterone. Aldosterone appears to be essential for complete adaptation and, in a relatively low dose, can completely restore potassium adaptation and the response to acute potassium loads in adrenalectomized rats.
authors.affiliation: Division of Clinical Sciences, Northwick Park Hospital, Harrow.
authors.forename: C J
authors.initials: CJ
authors.lastname: Edmonds
authors.forename: C L
authors.initials: CL
authors.lastname: Willis
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects; D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D003106:Colon / Q000187:drug effects / Q000502:physiology*; D008297:Male; D011188:Potassium / Q000097:blood / Q000493:pharmacokinetics / Q000502:physiology*; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D000450:Aldosterone; D011188:Potassium