Facilitation and antagonism of lidocaine-kindled seizures: the behavioral feature.
The role of the purinergic system in the genesis of lidocaine-kindled seizures has been studied. At the same time, in order to assess the behavioral changes in lidocaine-kindled rats, the animals were rated on an Albert and Richmond scale on the 7th, 14th and 21st day. Pretreatment with aminophylline (a blocker of adenosine receptors), in doses of 40 mg/kg, 30 minutes prior to lidocaine, potentiated seizure development and the manifestations of irritable-aggressive behavior in experimental animals. On the contrary, pretreatment with papaverine (a blocker of adenosine uptake) in doses of 40 mg/kg, also 30 minutes prior to lidocaine, was effective in preventing the appearance of lidocaine kindling phenomenon. These results demonstrated that purinergic modulation of synaptic transmission in the central nervous system in mammalia might play a significant role in the genesis of lidocaine-kindled seizures and behavioral changes.
Lekić
D M
DM
Institute of Pathophysiology, Medical Faculty, Beograd, Yugoslavia.
D000241:Adenosine / Q000502:physiology*; D000374:Aggression / Q000187:drug effects; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007696:Kindling, Neurologic / Q000187:drug effects*; D008012:Lidocaine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D010208:Papaverine / Q000494:pharmacology; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains
D000628:Aminophylline; D008012:Lidocaine; D010208:Papaverine; D000241:Adenosine