title: Bromocriptine suppresses postpartum exacerbation of collagen-induced arthritis.
abstract: We administered bromocriptine (Parlodel) to arthritic mice immediately postpartum, and found that the drug suppressed the clinical exacerbation of joint involvement that was seen in untreated animals. Approximately 50% reduction in severity of disease was achieved with bromocriptine (P less than 0.001). The effect may be due to suppression of the prolactin release that normally occurs postpartum.
authors.affiliation: AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, United Kingdom.
authors.forename: A
authors.initials: A
authors.lastname: Whyte
authors.forename: R O
authors.initials: RO
authors.lastname: Williams
mesh_terms: D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D001971:Bromocriptine / Q000627:therapeutic use*; D003094:Collagen / Q000494:pharmacology*; D005260:Female; D051379:Mice; D049590:Postpartum Period / Q000502:physiology*; D011247:Pregnancy
chemical_list: D001971:Bromocriptine; D003094:Collagen