[Interaction of the transcortin-progesterone complex with plasma membranes of human decidual epithelium].
It was demonstrated that transcortin complexed with progesterone specifically binds to plasma membranes of human decidual endometrium, a progesterone target tissue. This interaction is characterized by a high affinity [Kd = (1.0 +/- 0.2).10(-10) mol/l] and selectivity. Such human serum proteins as albumin, orosomucoid, transferrin, thyroxine- and sex steroid-binding globulins do not compete with transcortin for the binding sites on the membranes. The concentration of endogenous transcortin in sodium cholate-solubilized endometrium cell membranes was determined by the radioimmunoassay method.
Avvakumov
G V
GV
Krupenko
S A
SA
Dubovskaia
L V
LV
Strel'chenok
O A
OA
D001667:Binding, Competitive; D002462:Cell Membrane / Q000378:metabolism; D003656:Decidua / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism*; D014156:Transcortin / Q000378:metabolism*
D008565:Membrane Proteins; D011374:Progesterone; D014156:Transcortin
Vzaimodeĭstvie kompleksa transkortin-progesteron s plazmaticheskimi membranami kletok detsidual'nogo éndometriia cheloveka.