title: Antigenic cross-reactivity between the human whipworm, Trichuris trichiura, and the mouse trichuroids Trichuris muris and Trichinella spiralis.
abstract: Cross-reactivity was demonstrated between circulating antibodies from Trichuris trichiura-infected humans and T. muris-infected mice for heterologous antigen preparations. Mouse immune sera raised against excretory/secretory (E/S) products and anterior end homogenate from adult T. muris showed marked affinity for T. trichiura adult homogenate in ELISA, and 35S-methionine-labelled adult T. muris E/S products were precipitated by T. trichiura infection sera. Monoclonal antibodies recognizing a 48 kD Trichinella spiralis muscle larval beta-stichocyte granule antigen also showed avidity for T. trichiura adult homogenate in ELISA, as did serum from mice with patent T. muris worm burdens. This cross-reactivity is thought to result from shared stichocyte antigens and the relevance of this observation is discussed.
authors.affiliation: Department of Zoology, University of Nottingham, UK.
authors.forename: T I
authors.initials: TI
authors.lastname: Roach
authors.forename: D
authors.initials: D
authors.lastname: Wakelin
authors.forename: K J
authors.initials: KJ
authors.lastname: Else
authors.forename: D A
authors.initials: DA
authors.lastname: Bundy
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology*; D000947:Antigens, Helminth / Q000276:immunology*; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007118:Immunoassay; D008297:Male; D051379:Mice; D014234:Trichinella / Q000276:immunology*; D014257:Trichuriasis / Q000276:immunology*; D014258:Trichuris / Q000276:immunology*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007106:Immune Sera