title: Chestwall recurrences of breast cancer: results of combined treatment with radiation and hyperthermia.
abstract: In 35 patients with chestwall recurrences of breast carcinoma, 45 lesions were treated with combined radiation and hyperthermia. The majority of the lesions received 6 fractions of 4 Gy, twice a week during 3 weeks. Hyperthermia was administered within 30 min after irradiation, aiming a tumor temperature of 43 degrees C during one hour. The percentage of complete response (CR) was 57%. In small lesions, the percentage of CR was 80%. The mean duration of the response was 7 months. Response rate increased with increasing temperature. Particularly, mean temperature and isoeffect thermal dose correlated very well with response rate. In nine cases, comparative lesions were treated with either radiation alone or radiation combined with hyperthermia. The response rates were 3/9 and 7/9, respectively. Acute skin reactions were enhanced by the combined treatment. However, late skin reactions were not increased. Although the prognosis of patients with chestwall recurrences is determined by the presence of distant metastases, local control remains an important objective. Combined treatment with radiation and hyperthermia offers the possibility of obtaining a high local control rate particularly in relatively small lesions.
authors.affiliation: Department of Radiotherapy, University Hospital, University of Amsterdam, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Gonzalez Gonzalez
authors.forename: J D
authors.initials: JD
authors.lastname: van Dijk
authors.forename: L E
authors.initials: LE
authors.lastname: Blank
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D011879:Radiotherapy Dosage; D012867:Skin / Q000528:radiation effects; D013899:Thoracic Neoplasms / Q000628:therapy*