title: [The effect of S-adenosyl-L-methionine sulfate tosylate (FO-1561) on survival time in various brain damage models].
abstract: The effect of S-adenosyl-L-methionine sulfate tosylate (FO-1561) on survival time in various brain damage models (cerebral anoxia or ischemia) was studied. 1) In KCN-induced or normobaric anoxia of ddY mice, FO-1561 (30-100 mg/kg as amount of S-adenosyl-L-methionine) administered intravenously 15-30 min prior to the treatment showed significant increase of survival time dose-dependently. 2) In asphyxic anoxia of Wistar rats, FO-1561 (100 mg/kg) administered intravenously 15 min prior to the treatment (cessation of artificial respiration) delayed the time until the disappearance of electrocorticogram. 3) In cerebral ischemia of Mongolian gerbils, FO-1561 (50 mg/kg) injected five times at 1 hr interval intraperitoneally 3 hr after the unilateral ligation of common carotid arteries showed significant increase of survival time. These results suggested that FO-1561 may be effective in ameliorating cerebral anoxic or ischemic damage, without observing any side effects like sedation and motor depression which pentobarbital showed with the effective doses in these damage models.
authors.affiliation: Research Laboratories, Fuji Chemical Industry Co. Ltd., Toyama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Moriguchi
authors.forename: I
authors.initials: I
authors.lastname: Horita
authors.forename: H
authors.initials: H
authors.lastname: Hariyama
authors.forename: T
authors.initials: T
authors.lastname: Ushijima
authors.forename: M
authors.initials: M
authors.lastname: Nakano
mesh_terms: D000818:Animals; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000401:mortality; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D005849:Gerbillinae; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D012436:S-Adenosylmethionine / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D012436:S-Adenosylmethionine