title: Choledochal cysts. Oligoganglionosis in the narrow portion of the choledochus.
abstract: To investigate whether cystic dilation may be due to a reduction of postcholinergic cell bodies that leads to autonomic dysfunction, ganglion cell bodies were counted in five patients with choledochal cysts and five patients with normal choledochus. In the normal choledochus, the ganglion cell counts in the proximal and distal portions were 374.7 +/- 82.7/cm2 and 349.2 +/- 51.2/cm2, respectively. In cases of choledochal cysts, the ganglion cell counts in the dilated portion and narrow portions were 298.6 +/- 86.9/cm2 and 81.0 +/- 34.8/cm2, respectively. The cell ratio (narrow to dilated) was 0.271. Significant reductions of cell numbers were observed in all the choledochal cysts having various types of pancreatobiliary junctions. These findings indicate that the reduction in the number of ganglion cells in the narrow portion of the choledochal cysts supports the concept of oligoganglionosis in distal choledochus.
authors.affiliation: Second Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kusunoki
authors.forename: N
authors.initials: N
authors.lastname: Saitoh
authors.forename: T
authors.initials: T
authors.lastname: Yamamura
authors.forename: S
authors.initials: S
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: J
authors.initials: J
authors.lastname: Utsunomiya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002452:Cell Count; D003135:Common Bile Duct / Q000166:cytology / Q000294:innervation*; D003137:Common Bile Duct Diseases / Q000473:pathology*; D003560:Cysts / Q000473:pathology*; D005260:Female; D005725:Ganglia, Autonomic / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged