title: Lack of correlation between DST results and urinary MHPG in depressed inpatients.
abstract: Abnormalities of noradrenaline metabolism and of the activity of hypothalamic-pituitary adrenal axis (HPA) have been reported in depression. To study the possible relationship between these 2 parameters, urinary excretion of 3-methoxy-4-hydroxy-phenylethyleneglycol (MHPG) and Dexamethasone Suppression Test (DST) were analyzed in 58 depressed patients. A positive correlation was found between the age of depressed patients and 24-h urinary excretion of MHPG. Twenty-two patients (38%) were DST non suppressors. Pre-DST plasma cortisol levels were significantly higher in non suppressors than suppressors. No difference was found however between urinary MHPG levels in suppressors and non suppressors. There was no correlation between pre-DST plasma cortisol and levels of urinary excretion of MHPG. These results do not support the hypothesis of a relationship between these 2 parameters. However, when depressed patients were separated into two groups according to urinary excretion of MHPG ("high MHPG" and "low MHPG"), the "high MHPG" group included significantly more non suppressors then the "low MHPG" one. This result is not sufficient to demonstrate of link between HPA system activity and central noradrenaline metabolism.
authors.affiliation: Department of Mental Health and Therapeutics, Sainte Anne Hospital, Paris-Cochin University Clinic, France.
authors.forename: H
authors.initials: H
authors.lastname: Lôo
authors.forename: M F
authors.initials: MF
authors.lastname: Poirier
authors.forename: T
authors.initials: T
authors.lastname: Dennis
authors.forename: C
authors.initials: C
authors.lastname: Benkelfat
authors.forename: J M
authors.initials: JM
authors.lastname: Vanelle
authors.forename: C
authors.initials: C
authors.lastname: Gay
authors.forename: A
authors.initials: A
authors.lastname: Galinowski
authors.forename: S
authors.initials: S
authors.lastname: Askienazy
authors.forename: B
authors.initials: B
authors.lastname: Scatton
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003866:Depressive Disorder / Q000378:metabolism*; D003907:Dexamethasone; D005260:Female; D006018:Glycols / Q000652:urine*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000378:metabolism
chemical_list: D006018:Glycols; D008734:Methoxyhydroxyphenylglycol; D003907:Dexamethasone; D006854:Hydrocortisone