Bone density and cortical thickness in nutritional vitamin D deficiency: effect of secondary hyperparathyroidism.
Measurements of bone mineral index, mean metacarpal cortical thickness, plasma calcium, alkaline phosphatase and serum 25-hydroxyvitamin D and parathyroid hormone concentrations were carried out in 39 Asian vegetarian patients with hypovitaminosis D. It was concluded that PTH is probably the major determinant of osteopenia in patients with osteomalacia and secondary hyperparathyroidism; and that the presence of secondary hyperparathyroidism in association with hypovitaminosis D should be an absolute indication for vitamin D supplementation even in asymptomatic patients.
Fonseca
V
V
Department of Chemical Pathology, Royal Free Hospital and School of Medicine, London, UK.
Agnew
J E
JE
Nag
D
D
Dandona
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D001847:Bone Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications* / Q000473:pathology
D014807:Vitamin D; D002118:Calcium