title: Idiopathic bilateral lipid keratopathy.
abstract: A 52-year-old Mexican man presented with asymptomatic, bilaterally symmetrical lipid infiltrates of the cornea and adjacent limbus. No evidence of previous ocular disease or systemic disorder of lipid metabolism could be detected. Penetrating keratoplasty of the right eye was required. The cornea was rigid and thick, with posterior bulging into the anterior chamber. Light microscopy revealed deep corneal lipid granules, foamy histiocytes, vascularisation, and chronic non-granulomatous inflammation. Transmission electron microscopy showed extracellular lipid spaces and numerous intracytoplasmic lipid vacuoles in histiocytes, keratocytes, conjunctival epithelium, and the endothelium of blood vessels in the corneal stroma and adjacent limbal conjunctiva. Histochemical analysis revealed the presence of neutral fats, free fatty acids, cholesterol, and phospholipids.
authors.affiliation: Cornea Service, Massachusetts Eye and Ear Infirmary, Boston.
authors.forename: E
authors.initials: E
authors.lastname: Alfonso
authors.forename: L
authors.initials: L
authors.lastname: Arrellanes
authors.forename: S A
authors.initials: SA
authors.lastname: Boruchoff
authors.forename: L D
authors.initials: LD
authors.lastname: Ormerod
authors.forename: D M
authors.initials: DM
authors.lastname: Albert
mesh_terms: D002784:Cholesterol / Q000032:analysis; D003315:Cornea / Q000648:ultrastructure; D003316:Corneal Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003318:Corneal Opacity / Q000209:etiology; D005230:Fatty Acids, Nonesterified / Q000032:analysis; D006644:Histiocytes / Q000648:ultrastructure; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010743:Phospholipids / Q000032:analysis
chemical_list: D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D002784:Cholesterol