Stimulation by D-glucose of mitochondrial respiration.
D-glucose increases O2 uptake by cerebellum mitochondria. This effect is abolished by D-glucose-6-phosphate and D-mannoheptulose. It is proposed that the phosphorylation of D-glucose as catalyzed by bound hexokinase directly affects mitochondrial respiration.
Malaisse
W J
WJ
Laboratory of Experimental Medicine, Brussels Free University, Belgium.
Sener
A
A
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D002531:Cerebellum / Q000378:metabolism / Q000648:ultrastructure; D005947:Glucose / Q000494:pharmacology*; D066298:In Vitro Techniques; D008356:Mannoheptulose / Q000494:pharmacology; D008928:Mitochondria / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats
D000244:Adenosine Diphosphate; D008356:Mannoheptulose; D005947:Glucose