Primary structure of neuromedin U from the rat.
The primary structure of neuromedin U from the rat ileum was established as: Tyr-Lys-Val-Asn-Glu5-Tyr-Gln-Gly-Pro-Val10-Ala-Pro-Ser-Gly-+ ++Gly15-Phe-Phe-Leu- Phe-Arg20-Pro-Arg-Asn.NH2. There was no evidence for microheterogeneity. This amino acid sequence contains two deletions and nine substitutions compared with the neuromedin U-25 from the pig. In particular, the replacement of the Arg16-Arg17 processing site in the porcine peptide by Gly14-Gly15 in the rat means that a peptide corresponding to neuromedin U-8 was not found in the rat intestine.
Conlon
J M
JM
Clinical Research Group for Gastrointestinal Endocrinology of the Max-Planck-Gesellschaft, University of Göttingen, F.R.G.
Domin
J
J
Thim
L
L
DiMarzo
V
V
Morris
H R
HR
Bloom
S R
SR
D000595:Amino Acid Sequence; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D008297:Male; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000235:genetics* / Q000302:isolation & purification; D051381:Rats / Q000378:metabolism*; D011919:Rats, Inbred Strains
D009479:Neuropeptides; C056900:neuromedin U