Experimental Yersinia-associated arthritis in the spontaneously hypertensive rat.
Sterile arthritis resembling human reactive arthritis was induced in spontaneously hypertensive SHR rats by intravenous injection of live Yersinia enterocolitica 0:8. Histologically the synovitis appears as proliferation of the lining cell layer, with inflammatory cells present in the subsynovium. The inflammatory cells are mostly lymphocytes. Infection with Yersinia enterocolitica 0:3 or Yersinia pseudotuberculosis did not induce arthritis. Susceptibility to Yersinia-associated arthritis is not determined by the major histocompatibility complex (MHC), since rats of the normotensive control strain (WKY) with the same MHC do not develop arthritis.
Toivanen
P
P
Merilahti-Palo
R
R
Gripenberg
C
C
Söderström
K O
KO
Jaakkola
U M
UM
D000818:Animals; D001170:Arthritis, Infectious / Q000209:etiology* / Q000473:pathology; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013583:Synovial Membrane / Q000473:pathology; D015009:Yersinia Infections / Q000150:complications*; D015008:Yersinia enterocolitica; D015011:Yersinia pseudotuberculosis