Effects of intravenous injection of diatrizoate, iohexol or ioxilan on renal size, urine profiles and blood profiles in the rabbit.
Diatrizoate, iohexol or ioxilan were injected intravenously in 18 rabbits. The contrast medium passage through the kidneys was recorded on digital subtraction images for the first 50 s followed by 100 mm exposures up to 15 min after injection. The renal area was measured planimetrically. Urine profiles (glucose, phosphate, LDH, GGT, NAG), blood profiles (potassium, urea) and the relative clearance of albumin and sodium were followed for 5 days and compared with a control group injected with saline. All kidneys were examined by light and immunofluorescence microscopy. All three contrast media produced excellent arteriograms and urograms. The three different contrast media caused a rapid increase of the kidney area within the first minute, reaching an average maximum of 10 to 12 per cent after 5 min, followed by a gradual decline. Contrary to expectations the increase in renal area was similar for all three contrast media, so hyperosmolality is no likely explanation of this phenomenon. None of the contrast agents caused significant changes in any of the profile components with one exception: the GGT excretion was significantly elevated during the first 24 h after diatrizoate administration as compared with the effect of saline. Light and immunofluorescence microscopy revealed no differences.
Rygaard
H
H
Department of Diagnostic Radiology, Københavns Amts Sygehus I Herlev, Faculty of Medicine, University of Copenhagen, Denmark.
Dorph
S
S
Thomsen
H S
HS
Mygind
T
T
Nielsen
H
H
Larsen
S
S
Skaarup
P
P
Hemmingsen
L
L
Holm
J
J
D000818:Animals; D001774:Blood Chemical Analysis; D003973:Diatrizoate / Q000008:administration & dosage*; D005260:Female; D007275:Injections, Intravenous; D007472:Iohexol / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D007668:Kidney / Q000187:drug effects*; D011817:Rabbits; D014556:Urine / Q000032:analysis*; D014567:Urography
D003973:Diatrizoate; D007472:Iohexol; C055357:ioxilan