[Capacity of rhabdomyosarcoma cells to produce substances with somatomedin and mitogenic activity].
The rats aged 1, 3, 12 and 15 months were intravenously injected with 10,000 of the rhabdomyosarcoma cells. 3 weeks following the injection multiple tumour clones were observed in the lungs of experimental animals, the rats aged 1 and 15 months showing a significantly greater tumour yield than those aged 3 and 12 months. The level of the mitogenic and somatomedin activity increased both in the blood serum and in the lung tissue, the activity varying with the number of tumour clones. Rhabdomyosarcoma cells, probably, synthesize and release growth factors into the blood.
Vasil'eva
I A
IA
Kaminskaia
E V
EV
Zhukovskaia
N V
NV
Dil'man
V M
VM
D000818:Animals; D002999:Clone Cells / Q000378:metabolism; D005260:Female; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000378:metabolism*; D008934:Mitogens; D009368:Neoplasm Transplantation; D051381:Rats; D012208:Rhabdomyosarcoma / Q000378:metabolism*; D013002:Somatomedins / Q000096:biosynthesis*; D013997:Time Factors
D008934:Mitogens; D013002:Somatomedins
Sposobnost' kletok rabdomiosarkomy produtsirovat' veshchestva s somatomedinovoĭ i mitogennoĭ aktivnost'iu.