Sublocalization of the human PDGF A-chain gene to chromosome 7, band q11.23, by in situ hybridization.
The human platelet-derived growth factor A-chain (PDGFA) locus was mapped by in situ hybridization. By use of human cDNA probes encoding the PDGF A-chain precursor polypeptide the gene was assigned to the proximal long arm of chromosome 7, band q11.23. Of 76 cells with silver grains on chromosome 7, 28% had label over this band. Our assignment represents a confirmation and further sublocalization of the PDGFA locus. The location correlates with specific chromosomal abnormalities associated with certain human developmental malformations and neoplasms.
Stenman
G
G
Department of Oral Pathology, Göteborg University, Sweden.
Rorsman
F
F
Betsholtz
C
C
D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D008297:Male; D009693:Nucleic Acid Hybridization; D010957:Plasmids; D010982:Platelet-Derived Growth Factor / Q000235:genetics*
D010982:Platelet-Derived Growth Factor