title: Treatment of uncomplicated gonorrhea with single-dose imipenem-cilastatin.
abstract: Single 500-mg intramuscular doses of imipenem-cilastatin cured 116 (95%) of 122 men and 9 of 9 women with uncomplicated gonorrhea due to beta-lactamase-negative Neisseria gonorrhoeae. Most co-existing Chlamydia trachomatis infections persisted. Imipenem-cilastatin is effective for uncomplicated gonorrhea in men but has no advantages over other available regimens.
authors.affiliation: Department of Medicine, University of Washington School of Medicine, Seattle 98104.
authors.forename: M S
authors.initials: MS
authors.lastname: Verdon
authors.forename: F N
authors.initials: FN
authors.lastname: Judson
authors.forename: J M
authors.initials: JM
authors.lastname: Ehret
authors.forename: C J
authors.initials: CJ
authors.lastname: Root
authors.forename: E W
authors.initials: EW
authors.lastname: Hook
authors.forename: W M
authors.initials: WM
authors.lastname: McCormack
authors.forename: C A
authors.initials: CA
authors.lastname: Frances
authors.forename: K
authors.initials: K
authors.lastname: Draft
authors.forename: J W
authors.initials: JW
authors.lastname: Shands
authors.forename: H H
authors.initials: HH
authors.lastname: Handsfield
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000150:complications / Q000188:drug therapy; D002692:Chlamydia trachomatis; D015377:Cilastatin; D000077728:Cilastatin, Imipenem Drug Combination; D003521:Cyclopropanes / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006069:Gonorrhea / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D015378:Imipenem; D007273:Injections, Intramuscular; D008297:Male; D013845:Thienamycins / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D003521:Cyclopropanes; D004338:Drug Combinations; D013845:Thienamycins; D015377:Cilastatin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination