title: Analogs of cell surface carbohydrates. Synthesis of D-galactose derivatives having an ethynyl, vinyl or epoxy residue at C-5.
abstract: Compounds derived from D-galactose having an ethynyl, vinyl, or epoxide residue at C-5, as well as 7,7-dibromo olefinic, isomeric 7,7-gem-bromofluoro olefinic, and 6,6-gem-difluoro derivatives were obtained from 1,2:3,4-di-O-iso-propylidene-alpha-D-galacto-hexodialdo-1,5- pyranose.
authors.affiliation: Department of Experimental Therapeutics, Roswell Park Memorial Institute, Buffalo, New York 14263.
authors.forename: H H
authors.initials: HH
authors.lastname: Lee
authors.forename: P G
authors.initials: PG
authors.lastname: Hodgson
authors.forename: R J
authors.initials: RJ
authors.lastname: Bernacki
authors.forename: W
authors.initials: W
authors.lastname: Korytnyk
authors.forename: M
authors.initials: M
authors.lastname: Sharma
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002462:Cell Membrane / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004852:Epoxy Compounds / Q000138:chemical synthesis; D005690:Galactose / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000627:therapeutic use; D007202:Indicators and Reagents; D007939:Leukemia L1210 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D014753:Vinyl Compounds / Q000138:chemical synthesis
chemical_list: D000480:Alkynes; D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D007202:Indicators and Reagents; D014753:Vinyl Compounds; D005690:Galactose