[Prenatal effect of oleandomycin on the development of the immunogenesis organs].
The ante- and postnatal development of the thymus gland and mesenteric lymph nodes of the rats receiving oleandomycin in the period of placentation and organogenesis (the 8th-14th days of embryogenesis) was studied by using anatomical, histological and electron microscopical methods. Oleandomycin produced inhibition of lymphopoiesis against the background of an increase of eosinophilic and neutrophilic granulocytes, reactive changes of the microcirculatory bed and ultrastructural lesions of the blood capillary wall.
Petrova
T B
TB
Savitskaia
T N
TN
D000818:Animals; D000831:Animals, Newborn; D002465:Cell Movement / Q000187:drug effects; D005260:Female; D005865:Gestational Age; D007107:Immune System / Q000187:drug effects* / Q000196:embryology / Q000254:growth & development; D007958:Leukocyte Count / Q000187:drug effects; D008198:Lymph Nodes / Q000187:drug effects / Q000196:embryology / Q000254:growth & development; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D009827:Oleandomycin / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000187:drug effects / Q000196:embryology / Q000254:growth & development
D009827:Oleandomycin
Prenatal'noe vliianie oleandomitsina na razvitie organov immunogenez.