Potentiation of cis-diamminedichloroplatinum nephrotoxicity by amikacin in rats.
The nephrotoxic interaction between cis-diamminedichloroplatinum (CDDP) and amikacin (AMI) was studied in rats. Following a single dose of CDDP (5 mg/kg i.v.), AMI (60 mg/kg s.c.) was given for 14 days. When given alone CDDP caused a 40% fall in the glomerular filtration rate (GFR), whereas AMI alone had no effect on GFR. This nonnephrotoxic course of AMI potentiated the CDDP-induced fall in GFR. Only a limited recovery of renal function was observed during a 15-week follow-up period.
Jongejan
H T
HT
Department of Pediatric Surgery, Erasmus University, Rotterdam, The Netherlands.
Provoost
A P
AP
Molenaar
J C
JC
D000583:Amikacin / Q000633:toxicity*; D000818:Animals; D002945:Cisplatin / Q000633:toxicity*; D004357:Drug Synergism; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000098:blood supply / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects
D000583:Amikacin; D002945:Cisplatin