Carbazomycins G and H, novel carbazomycin-congeners containing a quinol moiety.
Carbazomycins G (I) and H (II), new congeners of the carbazomycin complex, have been isolated from the culture broth of Streptoverticillium ehimense. They have proved to contain a unique quinol moiety in the molecule. Their structures have been elucidated by mass and NMR spectrometries and X-ray crystallographic analysis. Carbazomycin G showed moderate antifungal activity against Trichophyton species.
Kaneda
M
M
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.
Naid
T
T
Kitahara
T
T
Nakamura
S
S
Hirata
T
T
Suga
T
T
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D002227:Carbazoles / Q000302:isolation & purification / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003461:Crystallography; D004353:Drug Evaluation, Preclinical; D006873:Hydroquinones / Q000302:isolation & purification; D008958:Models, Molecular; D013057:Spectrum Analysis; D013306:Streptomycetaceae / Q000032:analysis; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D002227:Carbazoles; D006873:Hydroquinones; C056332:carbazomycin H; C056331:carbazomycin G