[DNA impulse cytophotometric studies of the modification of the proliferation behavior of the outer hair root sheath by topical glucocorticoid administration].
A corticoid preparation (C) was topically applied on the scalps of 47 healthy test persons for 7 or 14 days, resp. After this treatment, we plucked anagen hairs under standardized conditions both from the area treated with C and the contralateral, untreated area. The proliferative activity of plucked anagen hairs with root sheaths was analyzed by means of DNA flow cytometry. Already a 7 days treatment with topical C resulted in kinetic changes of the outer root sheath: The percentage of the cells in the G1/10-phase of the cell cycle was increased, whereas that of the cells in the S-phase and the G2+M-phase was decreased.
Schell
H
H
Dermatologische Universitäts-Klinik Erlangen.
Kiesewetter
F
F
Pausch
C
C
Arai
A
A
D001623:Betamethasone / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D004261:DNA Replication / Q000187:drug effects*; D004334:Drug Administration Schedule; D005434:Flow Cytometry; D006197:Hair / Q000187:drug effects*; D006801:Humans; D007399:Interphase / Q000187:drug effects; D012535:Scalp / Q000187:drug effects*
D001623:Betamethasone
DNS-Impulscytophotometrische Untersuchungen über die Beeinflussung des Proliferationsverhaltens der äusseren Haarwurzelscheide durch topische Glukokortikoid-Applikation.