[Experimental study on lipid metabolism after partial hepatectomy--with reference to mitochondrial function of the regenerating liver].
Lipid metabolism after hepatectomy was studied in normal rats and cirrhotic rats induced with injections of thioacetamide. In normal rats, the fat accumulation in regenerating livers was observed, which had a maximal peak at 24 hours after hepatectomy. It could be a result of mobilization of fatty acids from fat tissue accompanied with hyperglucagonemia after hepatectomy. Mitochondrial respiration in regenerating liver increased remarkably. Especially when palmitoylcarnitine was used as a substrate, both the respiratory index and ATP synthesis were high until 72 hours after hepatectomy. Mitochondrial carnitine palmitoyltransferase activity was also high. The increase of mitochondrial respiration with palmitoylcarnitine as a substrate was also observed in cirrhotic liver until 72 hours after hepatectomy. These results suggest that mobilization of fatty acids increases after hepatectomy and regenerating liver utilizes fatty acids as a main substrate for hepatic regeneration.
Katagiri
S
S
First Department of Surgery, Yamagata University School of Medicine, Japan.
D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D006498:Hepatectomy; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D005227:Fatty Acids