[Suppression of the proliferative activity in in vivo tissue culture of esophageal and stomach tumor cells during preoperative irradiation].
Pathomorphological changes and indices of proliferative ability of tumour tissue in the esophagus and in the cardia are studied in 14 patients after and without the preoperative irradiation following its cultivation in diffuse chambers. The tissue was implanted into the abdominal cavity of 84 rats. Inhibition of the mitotic activity and synthesis of DNA in cell nuclei as well as the impairment of the formation processes typical of the unirradiated blastomas of the same histological structure in the tissue culture in vivo evidence for a pronounced effect of irradiation.
Zinchenko
V A
VA
Okulov
L V
LV
Gol'dshmid
B Ia
BIa
D000230:Adenocarcinoma / Q000473:pathology / Q000532:radiotherapy*; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D002471:Cell Transformation, Neoplastic / Q000473:pathology / Q000528:radiation effects*; D046508:Culture Techniques / Q000379:methods; D004273:DNA, Neoplasm / Q000528:radiation effects; D004938:Esophageal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008938:Mitosis / Q000528:radiation effects; D011300:Preoperative Care; D051381:Rats; D013274:Stomach Neoplasms / Q000473:pathology / Q000532:radiotherapy*
D004273:DNA, Neoplasm
Ugnetenie proliferativnoĭ aktivnosti v kul'ture tkani in vivo kletok opukholeĭ pishchevoda i zheludka pri predoperatsionnom obluchenii.