X-ray or gamma-ray leukemogenesis at Hiroshima and Nagasaki.
Because of the uncertainty in dosimetry at the Japanese cities, I have recalculated the probability of x-ray or gamma-ray leukemogenesis using the revised doses given by the Livermore group. The theory is of the two hit type. The first hit damages DNA repair capability of base damage. The second hit causes derepression of a two repressor system. Inactivation of the first repressor permits synthesis of the second which will repress the expression of the leukocyte maturation gene. In comparing the observed data, I convert data expressed as mortality per year to leukemia incidence. I also supply evidence of the lack of the importance of chromosomal aberration and consider CML, AML, and ALL data lumped together. Agreement between theory and observation is good.
Rosen
P
P
Hasbrouck Laboratory, University of Massachusetts, Amherst 01003.
D004247:DNA / Q000528:radiation effects; D005720:Gamma Rays; D006801:Humans; D007564:Japan; D007953:Leukemia, Radiation-Induced / Q000209:etiology*; D009689:Nuclear Warfare; D011336:Probability; D011519:Proto-Oncogenes; D011829:Radiation Dosage; D014965:X-Rays
D004247:DNA