Cross-tolerance between amineptine, an atypical antidepressant and cocaine in mice.
The effects of amineptine and cocaine on locomotor activity were studied in two sets of experiments, by using C57BL/6 mice. In a first set, activity enhancements were evident following acute administration of both drugs. In addition to that the effects of amineptine were additive with those of cocaine. In a second set of experiments, mice developed tolerance to the stimulatory effects of both amineptine and cocaine, and a clear cross-tolerance effect was evident in mice chronically injected with these drugs. The results are discussed in terms of the involvement of dopaminergic mechanisms in the activity stimulating action of amineptine.
Filibeck
U
U
Institute of Psychobiology and Psychopharmacology, CNR, Rome, Italy.
Castellano
C
C
Oliverio
A
A
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D004361:Drug Tolerance; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects*
D000928:Antidepressive Agents; D003986:Dibenzocycloheptenes; C011597:amineptin; D003042:Cocaine