title: Hb Las Palmas or alpha 2 beta 2(49)(CD8)Ser----Phe, a mildly unstable hemoglobin variant.
abstract: A new hemoglobin variant with a Ser----Phe substitution at position beta 49(CD8) was discovered in two members of a family living in the Canary Islands, Spain. Detection was by polyacrylamide gel electrophoresis and by reversed phase high performance liquid chromatography. The variant, which constituted 43% and 45%, respectively, in the two heterozygotes, was slightly unstable. Its presence did not affect hematological values though there was a mild reticulocytosis.
authors.affiliation: Departamento de Hematologia-Hemoterapia Hospital Materno-Infantil, Insalud, Canary Islands, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Malcorra-Azpiazu
authors.forename: M I
authors.initials: MI
authors.lastname: Balda-Aguirre
authors.forename: J C
authors.initials: JC
authors.lastname: Diaz-Chico
authors.forename: H
authors.initials: H
authors.lastname: Hu
authors.forename: J B
authors.initials: JB
authors.lastname: Wilson
authors.forename: B B
authors.initials: BB
authors.lastname: Webber
authors.forename: F
authors.initials: F
authors.lastname: Kutlar
authors.forename: A
authors.initials: A
authors.lastname: Kutlar
authors.forename: T H
authors.initials: TH
authors.lastname: Huisman
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D005914:Globins / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics* / Q000302:isolation & purification; D006579:Heterozygote; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D013030:Spain
chemical_list: D006455:Hemoglobins, Abnormal; C056395:hemoglobin Las Palmas; D005914:Globins