Acute effects of retinoids on fibrinolysis before and after venous occlusion in healthy humans.
The effects of acitretin and etretinate on the fibrinolytic system have been investigated in a double-blind, placebo-controlled cross-over study in twelve healthy volunteers. Euglobulin fibrinolytic activity, euglobulin clot lysis time, tissue-type plasminogen activator (t-PA) activity and antigen concentration in plasma were measured before and after 10 min of venous occlusion (VO), three hours after ingestion of the compounds. The plasminogen activator inhibitor (PAI) activity was also measured in each session before fibrinolysis stimulation. None of the parameters studied was significantly affected by the two retinoids in comparison with placebo. Our study demonstrates that a single oral dose of 100 mg of etretinate or acitretin, investigated 3 hours after drug administration does not significantly influence the fibrinolytic system in vivo in humans. This observation does not exclude an effect of retinoids after prolonged intake.
Bounameaux
H
H
Department of Medicine, University Hospital of Geneva, Switzerland.
Reber
G
G
Bounameaux
Y
Y
D000328:Adult; D003250:Constriction; D005342:Fibrinolysis / Q000187:drug effects*; D005542:Forearm / Q000098:blood supply; D006801:Humans; D008297:Male; D012176:Retinoids / Q000494:pharmacology*; D014680:Veins
D012176:Retinoids