[Photosensitization by chlorine and porphyrin causing structural damage of erythrocytes].
Kinetics of hemolysis of human erythrocytes photosensitized by porphyrin and chlorin derivatives was investigated by small angle light scattering method. The compounds used were arranged in the following order of photosensitizing activity decrease: ethylendiamide of chlorine e6, chlorine e6 dimethylester chlorine e6 haematoporphyrin diacetate tetracarboxyphenylporphyn. The substances having a greater number of binding sites with liposomes (chlorine e6 dimethylester) or with albumin (ethylendiamide of chlorine e6) showed the greatest photohemolytic activity. The photohemolytic activity of porphyrins was suggested to depend on the number of the pigment molecules bound by erythrocytes membranes.
Gurinovich
G P
GP
Zorina
T E
TE
Zorin
V P
VP
Sarzhevskaia
M V
MV
Cherenkevich
S N
SN
D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects*; D006461:Hemolysis / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D066298:In Vitro Techniques; D008027:Light; D010777:Photochemistry; D011166:Porphyrins / Q000494:pharmacology*; D012542:Scattering, Radiation
D011166:Porphyrins; C006969:chlorin
Fotosensibilizirovannye khlorinami i porfirinami structurnye povrezhdeniia éritrotsitov.