title: Effect of ivermectin against subperiodic Brugia malayi infection in the leaf monkey, Presbytis cristata.
abstract: Ivermectin at single doses of 0.2-1.0 mg/kg body weight reduced the microfilarial counts of subperiodic Brugia malayi in Presbytis cristata by 59.9%-89.6% of initial counts, 4 weeks after treatment. Adult filaricidal activity was poor, live adult worms being recovered from all animals at autopsy. There was no serious side effect at these doses.
authors.affiliation: Institute for Medical Research, Kuala Lumpur, Malaysia.
authors.forename: J W
authors.initials: JW
authors.lastname: Mak
authors.forename: P L
authors.initials: PL
authors.lastname: Lam
authors.forename: A N
authors.initials: AN
authors.lastname: Rain
authors.forename: K
authors.initials: K
authors.lastname: Suresh
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002009:Brugia / Q000187:drug effects; D002520:Cercopithecidae; D004605:Elephantiasis, Filarial / Q000188:drug therapy*; D005368:Filariasis / Q000188:drug therapy*; D007279:Injections, Subcutaneous; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007559:Ivermectin