title: XY sex reversal syndrome in the mare: clinical and behavioral studies, H-Y phenotype.
abstract: An inherited genetic disorder causes XY embryos of the horse to develop as mares. On the basis of our study of 38 such mares, we have identified four grades or classes of XY sex reversal according to this scheme: class I, nearly normal female, of which some are fertile; class II, female with gonadal dysgenesis, normal mullerian development; class III, intersex mare with gonadal dysgenesis, abnormal mullerian development, enlarged clitoris; class IV, virilized intersex characterized by high levels of testosterone. In general, class I and class II mares were typed H-Y antigen-negative whereas class III and class IV mares were typed H-Y antigen-positive.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38163.
authors.forename: M G
authors.initials: MG
authors.lastname: Kent
authors.forename: R N
authors.initials: RN
authors.lastname: Shoffner
authors.forename: A
authors.initials: A
authors.lastname: Hunter
authors.forename: K O
authors.initials: KO
authors.lastname: Elliston
authors.forename: W
authors.initials: W
authors.lastname: Schroder
authors.forename: E
authors.initials: E
authors.lastname: Tolley
authors.forename: S S
authors.initials: SS
authors.lastname: Wachtel
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D012734:Disorders of Sex Development / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005836:Genitalia, Female / Q000473:pathology; D006060:Gonadal Dysgenesis, Mixed / Q000473:pathology / Q000662:veterinary; D006182:H-Y Antigen / Q000032:analysis; D006734:Horse Diseases / Q000235:genetics* / Q000473:pathology; D006736:Horses / Q000235:genetics*; D008297:Male; D010375:Pedigree; D010641:Phenotype; D012732:Sex Determination Analysis; D013737:Testis / Q000473:pathology
chemical_list: D006182:H-Y Antigen