title: Inactivation of human immunodeficiency virus during human growth hormone production.
abstract: Since human immunodeficiency virus (HIV) has been found in the brains of AIDS patients, the possibility was investigated that preparations of human growth hormone (hGH) extracted from human pituitary glands harbor infectious HIV. It was found that the procedure used for extracting hGH, i.e. a combination of acid pH and 10% ethanol, totally inactivates HIV infectivity.
authors.affiliation: Centre de Recherches, Service de Santé des Armées, Clamart, France.
authors.forename: D
authors.initials: D
authors.lastname: Dormont
authors.forename: B
authors.initials: B
authors.lastname: Vaslin
authors.forename: D
authors.initials: D
authors.lastname: Dubeaux
authors.forename: F
authors.initials: F
authors.lastname: Boussin
authors.forename: F
authors.initials: F
authors.lastname: Maillard
authors.forename: J P
authors.initials: JP
authors.lastname: Deslys
mesh_terms: D000998:Antiviral Agents; D002478:Cells, Cultured; D004340:Drug Contamination / Q000517:prevention & control; D000431:Ethanol / Q000494:pharmacology; D013006:Growth Hormone / Q000302:isolation & purification*; D006678:HIV / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D014462:Ultrafiltration; D014508:Urea / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D000431:Ethanol; D014508:Urea; D013006:Growth Hormone