Collagen biosynthesis in a case of infantile myofibromatosis.
Cells from a skin nodule from a patient with a recurrent form of familial myofibromatosis were cultivated in vitro. A metabolic study showed that these cells behaved like fibroblasts with collagen synthesis, a normal percentage of type III collagen, hydroxylation rate and the ability to contract a collagen gel. The main disturbances were the decreased synthesis and increased cell multiplication rate after a lag phase. This behavior was compared with that of a fibroblast culture from normal skin.
Chamson
A
A
Laboratory of Biochemistry, Medical School, Saint-Etienne, France.
Frey
J
J
Frappaz
D
D
Damon
G
G
Freycon
F
F
Lauras
B
B
D003094:Collagen / Q000096:biosynthesis*; D004273:DNA, Neoplasm / Q000032:analysis; D005350:Fibroma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007223:Infant; D007700:Kinetics; D007889:Leiomyoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis / Q000096:biosynthesis; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D003094:Collagen