title: Weight cycling in female rats increases dietary fat selection and adiposity.
abstract: The effect of repeated food restriction-refeeding (weight cycling) on macronutrient selection and adiposity was investigated in female Sprague-Dawley rats. Rats were maintained on ad lib macronutrient self-selection and were put on one of two types of restriction. One group was reduced to 75% of their body weight on restricted amounts of chow and a second group was given ad lib chow during the concurrent period and were voluntarily hypophagic. During refeeding on macronutrient self-selection, animals previously restricted selected a higher percentage of dietary fat, had larger adipose depots and plasma insulin values, and had lower heart weights both expressed in grams and as a percentage of body weight than non-restricted groups. This suggests that both severe and moderate periods of restriction may have negative health consequences.
authors.affiliation: Monell Chemical Senses Center, Philadelphia, PA 19104.
authors.forename: D R
authors.initials: DR
authors.lastname: Reed
authors.forename: R J
authors.initials: RJ
authors.lastname: Contreras
authors.forename: C
authors.initials: C
authors.lastname: Maggio
authors.forename: M R
authors.initials: MR
authors.lastname: Greenwood
authors.forename: J
authors.initials: J
authors.lastname: Rodin
mesh_terms: D000818:Animals; D001835:Body Weight; D004041:Dietary Fats / Q000008:administration & dosage*; D002149:Energy Intake; D005260:Female; D005518:Food Preferences; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004041:Dietary Fats