The effect of oxygen on in vitro studies on methemoglobin production in man and dog blood using 4-dimethylaminophenol.
Methemoglobin production induced by the addition of 4-dimethylaminophenol to human or beagle blood in vitro is inhibited at high oxyhemoglobin levels. The effect is similar in the two species and probably results from conformational change in hemoglobin consequent on oxygen binding.
Woodman
A C
AC
Medical Division Chemical Defence Establishment, Salisbury, Wiltshire, UK.
Bright
J E
JE
Marrs
T C
TC
D000627:Aminophenols / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D006801:Humans; D066298:In Vitro Techniques; D008706:Methemoglobin / Q000096:biosynthesis*; D010100:Oxygen / Q000097:blood*
D000627:Aminophenols; D008706:Methemoglobin; D010100:Oxygen; C020292:4-dimethylaminophenol