Malignant monophasic multiple sclerosis or "Marburg's disease".
We report a patient with an acute monophasic demyelinating disease leading to death 29 days after onset. Neuroimaging showed progressive white matter attenuation, and neuropathology was characteristic of multiple sclerosis. Death in acute MS of the Marburg type may result from severe disseminated demyelination or involvement of critical brainstem structures.
Mendez
M F
MF
Case Western Reserve University, Cleveland, OH.
Pogacar
S
S
D000208:Acute Disease; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed