title: Efficacy of topically administered ivermectin against chorioptic and sarcoptic mange of cattle.
abstract: The efficacy of topically administered ivermectin against Chorioptes bovis and Sarcoptes scabiei var bovis on cattle was evaluated in five studies involving a total of 68 cattle. Treatment with ivermectin solution at a dose rate of 500 micrograms/kg bodyweight topically once was fully effective against C bovis and S scabiei when applied to healthy skin. Efficacy against S scabiei was impaired when the formulation was applied over areas of severe lesions caused by this parasite, presumably due to reduced absorption of ivermectin.
authors.affiliation: Merck Sharp & Dohme Research Laboratories, Lauterbach, West Germany.
authors.forename: D
authors.initials: D
authors.lastname: Barth
authors.forename: J M
authors.initials: JM
authors.lastname: Preston
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology; D004341:Drug Evaluation / Q000662:veterinary; D005260:Female; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008924:Mite Infestations / Q000188:drug therapy / Q000662:veterinary*; D012532:Scabies / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D007559:Ivermectin