Cross-protection of infant mice against intestinal colonisation by Campylobacter jejuni: importance of heat-labile serotyping (Lior) antigens.
An association of the heat-labile antigens detected by the Lior serotyping scheme with ability to protect infant mice against gastrointestinal colonisation with Campylobacter jejuni has been established. Overall, 39 (57%) of 68 infant mice challenged with a heterologous strain of the same Lior serotype as the vaccine strain were protected, compared with 40 (85%) of 47 infants protected against a homologous challenge. In contrast, none of the infant mice challenged with a strain carrying the same heat-stable antigens (i.e., of the same Penner serotype as the vaccine strain) were protected.
Abimiku
A G
AG
Division of Communicable Diseases, MRC Clinical Research Centre, Harrow, Middlesex.
Dolby
J M
JM
D000372:Agglutination Tests; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D002168:Campylobacter fetus / Q000145:classification / Q000276:immunology*; D006358:Hot Temperature; D007422:Intestines / Q000382:microbiology*; D051379:Mice; D012703:Serotyping
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines