NCAM-180, the largest component of the neural cell adhesion molecule, is reduced in dysmyelinating quaking mutant mouse brain.
To explore the role of the neural cell adhesion molecule (NCAM) in myelination and remyelination, we studied the developmental expression of various molecular forms of NCAM in dysmyelinating quaking mouse brain as compared with normal mouse brain. Normal mouse brain expressed the several molecular forms differentially during development. Quaking showed a marked reduction in the expression of NCAM-180, which represents the largest component of NCAM, in comparison with normal brain. This suggests that the defective myelin compaction in the quaking mutation may be the result of a deficiency of NCAM-180.
Bhat
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Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104.
Silberberg
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D000367:Age Factors; D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism* / Q000502:physiology; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D015815:Cell Adhesion Molecules; D003711:Demyelinating Diseases / Q000378:metabolism* / Q000503:physiopathology; D051379:Mice; D008821:Mice, Quaking / Q000254:growth & development / Q000378:metabolism*; D008970:Molecular Weight
D000954:Antigens, Surface; D015815:Cell Adhesion Molecules