title: The effects of low-level carbon monoxide exposure upon evoked cortical potentials in young and elderly men.
abstract: The neurophysiological effects of acute, low-level carbon monoxide (CO) exposure are not well known. This experiment investigated the effects of a 5% carboxyhemoglobin level upon two indices of neurophysiological function, reaction time and the late positive component of the visual evoked potential in young and elderly men. Results indicated (1) no effects of CO upon any of the neurophysiological indices and (2) greater absorption of CO by young than by elderly men. These results, along with those of other studies, indicate that acute, low-level CO exposure is probably not neurotoxic, in normal, healthy men.
authors.affiliation: U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.
authors.forename: T J
authors.initials: TJ
authors.lastname: Harbin
authors.forename: V A
authors.initials: VA
authors.lastname: Benignus
authors.forename: K E
authors.initials: KE
authors.lastname: Muller
authors.forename: C N
authors.initials: CN
authors.lastname: Barton
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002249:Carbon Monoxide Poisoning / Q000097:blood / Q000503:physiopathology*; D002263:Carboxyhemoglobin / Q000378:metabolism; D002540:Cerebral Cortex / Q000503:physiopathology*; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000187:drug effects
chemical_list: D002263:Carboxyhemoglobin