[Antiulcer activity of dibunol in experimental stomach and duodenal ulcers].
The antiulcer effect of two medicinal forms (oil solution, liniment) of dibunol in rats with different models of the stomach and duodenum ulcers was studied. The therapeutic activity of dibunol was evaluated by determining the index of ulcer formation as well as during the morphological and histochemical studies. The two medicinal forms of dibunol possessed equal antiulcer activity by all studied criteria. One should note a characteristic property of dibunol--its ability to produce pronounced epithelialization of ulceroerosive and ulceronecrotic lesions of the mucosa without rough scarring.
Shatalov
V N
VN
Korman
D B
DB
Krutova
T V
TV
Sokolov
L K
LK
Andrianova
O P
OP
D000818:Animals; D000897:Anti-Ulcer Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D005753:Gastric Mucosa / Q000201:enzymology / Q000473:pathology; D006651:Histocytochemistry; D007413:Intestinal Mucosa / Q000201:enzymology / Q000473:pathology; D008038:Liniments; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012996:Solutions; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D013997:Time Factors
D000897:Anti-Ulcer Agents; D008038:Liniments; D012996:Solutions; D002084:Butylated Hydroxytoluene
Protivoiazvennaia aktivnost' dibunola pri éksperimental'nykh iazvakh zheludka i dvenadtsatiperstnoĭ kishki.