Effect of lectins on KK-47 bladder cancer cell line.
The effect of three lectins, Ricinus communis agglutinin (RCA II), concanavalin agglutinin (ConA), and wheat germ agglutinin (WGA), on KK-47 bladder cancer cell line was studied, RCA II showed effective inhibition of H3-uridine and H3-thymidine uptake by KK-47. ConA showed a stimulatory effect in all three concentrations used. WGA also showed stimulatory effect, but it was less pronounced than ConA.
Bazeed
M A
MA
Department of Urology, University of Mainz Medical School, F. R. Germany.
Becht
E
E
Schärfe
T
T
Schmidt
J
J
Jacobi
G H
GH
Thüroff
J W
JW
D002277:Carcinoma / Q000378:metabolism; D002367:Ricinus communis; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D037102:Lectins / Q000493:pharmacokinetics / Q000494:pharmacology*; D037121:Plant Lectins; D010947:Plants, Toxic; D013936:Thymidine / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014529:Uridine / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000378:metabolism; D014909:Wheat Germ Agglutinins / Q000494:pharmacology
D037102:Lectins; D037121:Plant Lectins; C017707:Ricinus communis agglutinin-1; D014909:Wheat Germ Agglutinins; D003208:Concanavalin A; D013936:Thymidine; D014529:Uridine