Genetic selection for insulin-like growth factor-1 in growing mice is associated with altered growth.
Substantial responses in the 6-week and mature body-weights of mice occurred after 7 generations of selection for or against plasma levels of Insulin-like Growth Factor-1 (IGF-1). Plasma levels of IGF-1 were also significantly different after 7 generations of selection (high line = 85 +/- 2 ng/ml, low line = 58 +/- 2 ng/ml). The average 6-week weight in the line selected for high plasma IGF-1 was 22.5 +/- .2 g compared with 18.5 +/- .2 g in the low plasma IGF-1 line, after 7 generations of selection. The difference between lines was maintained at 20 weeks of age. These data provide further evidence for the roles of IGF-1 in the regulation of somatic growth and as a mediator of a genetic component of growth.
Blair
H T
HT
Department of Animal Science, Massey University, Palmerston North, New Zealand.
McCutcheon
S N
SN
Mackenzie
D D
DD
Ormsby
J E
JE
Siddiqui
R A
RA
Breier
B H
BH
Gluckman
P D
PD
D000375:Aging; D000818:Animals; D001835:Body Weight; D066298:In Vitro Techniques; D007334:Insulin-Like Growth Factor I / Q000097:blood / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains / Q000254:growth & development*; D012641:Selection, Genetic; D013002:Somatomedins / Q000235:genetics*
D013002:Somatomedins; D007334:Insulin-Like Growth Factor I