title: The effect of colchicine on synaptonemal complex formation in Allium ursinum.
abstract: Interference of colchicine with meiotic chromosome pairing in the wild garlic, Allium ursinum, was studied using a whole-mount spreading technique for synaptonemal complexes. Colchicine was found to cause (i) pairing suppression (arrest of leptotene) and (ii) deficient pairing initiation at zygotene in connection with morphologically anomalous, malfunctioning pairing initiation sites. Both of these phenomena could be responsible for the reduction of chiasma frequency by colchicine previously reported in the literature.
authors.affiliation: Department of Cytology and Genetics, University of Vienna, Wien, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Loidl
mesh_terms: D000490:Allium / Q000166:cytology* / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology*; D008540:Meiosis / Q000187:drug effects*; D011418:Prophase / Q000187:drug effects; D013573:Synaptonemal Complex / Q000187:drug effects*
chemical_list: D003078:Colchicine