Pyruvate carboxylase, phosphate-dependent glutaminase and glutamate dehydrogenase in the developing rat small intestinal mucosa.
The activities of glutaminase and glutamate dehydrogenase in the small intestinal mucosa of infant rats were found to increase at the time of weaning. Pyruvate carboxylase activity, on the other hand, was very high during the suckling period and decreased to negligible values at weaning. It is suggested that gluconeogenesis in the infant mucosa occurs primarily via oxaloacetate and not via alpha-ketoglutarate.
Hahn
P
P
Department of Obstetrics, University of British Columbia, Vancouver, Canada.
Taller
M
M
Chan
H
H
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000833:Animals, Suckling; D002952:Citric Acid Cycle; D005969:Glutamate Dehydrogenase / Q000378:metabolism*; D005972:Glutaminase / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D007413:Intestinal Mucosa / Q000201:enzymology*; D007421:Intestine, Small / Q000201:enzymology*; D008928:Mitochondria / Q000201:enzymology; D010710:Phosphates / Q000378:metabolism; D011766:Pyruvate Carboxylase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014886:Weaning
D010710:Phosphates; D005969:Glutamate Dehydrogenase; D005972:Glutaminase; D011766:Pyruvate Carboxylase