Stereotaxic injection of kainic acid into the striatum of rats induces synthesis of mRNA for heat shock protein 70.
Stereotaxic injection of the excitotoxin kainic acid into the striatum of rats has been shown to induce the production of messenger RNA to the 70 kDa heat shock protein. This was evident 2 h after injection and was maximal 24 h after injection of kainic acid. No change in the level of messenger RNA to beta-actin was detected.
Uney
J B
JB
St George's Hospital Medical School, Department of Immunology, London, England.
Leigh
P N
PN
Marsden
C D
CD
Lees
A
A
Anderton
B H
BH
D000199:Actins / Q000235:genetics; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000235:genetics*; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*
D000199:Actins; D006360:Heat-Shock Proteins; D012333:RNA, Messenger; D007608:Kainic Acid