[Disturbance of the mechanical integration of cells in tissues in the occurrence of spontaneous hepatomas and lung adenomas in mice].
The force (F) and coefficient of stability (Cst) of cell cohesion were measured in the liver parenchyma from CBA mice and in alveolar epithelium of the lung from A mice (genetically susceptible to spontaneous tumours) aged 1 to 13 months. Coefficients of F and Cst magnitude variation increase, while those of mean Cst decrease in animals aged 9 months in the both tissues. In spontaneous tumours F and Cst decrease more considerably. In the nontumour tissue near the tumours the Cst coefficient increases again, but the F coefficient remains low. The author considers that a decrease in the mechanical cell integration of the tissue is necessarily involved into the process of blastomogenesis and that a decrease of F stimulates the tumour promotion.
Modianova
E A
EA
D000236:Adenoma / Q000209:etiology / Q000473:pathology*; D000818:Animals; D002448:Cell Adhesion; D004198:Disease Susceptibility; D004848:Epithelium / Q000473:pathology; D008099:Liver / Q000473:pathology*; D008114:Liver Neoplasms, Experimental / Q000209:etiology / Q000473:pathology*; D008175:Lung Neoplasms / Q000209:etiology / Q000473:pathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011650:Pulmonary Alveoli / Q000473:pathology*; D009762:o-Aminoazotoluene
D009762:o-Aminoazotoluene
Narushenie mekhanicheskoĭ integratsii kletok v tkaniakh pri vozniknovenii spontannykh gepatom i adenom legkogo u mysheĭ.