Isolation of a new phenazine antibiotic, DOB-41, from Pseudomonas species.
A new phenazine antibiotic, DOB-41, was isolated from the culture broth of a Pseudomonas strain. The antibiotic obtained as yellow crystals showed UV maxima at 255 nm and 370 nm. A molecular formula, C19H18N2O6, was indicated by elemental analysis and mass spectrometry. The structure was elucidated by X-ray diffraction analysis. The antibiotic exhibited inhibitory activity against Gram-positive bacteria, and antitumor effect against leukemia P388 in mice.
Shoji
J
J
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Sakazaki
R
R
Nakai
H
H
Terui
Y
Y
Hattori
T
T
Shiratori
O
O
Kondo
E
E
Konishi
T
T
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D010619:Phenazines / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D011549:Pseudomonas / Q000032:analysis / Q000145:classification; D013057:Spectrum Analysis; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D010619:Phenazines; C056339:DOB-41 antibiotic