Chromosomal rearrangement involving chromosomes 4, 6, 11 and 11.
The case of a healthy 29-year-old woman is reported who had a history of three early spontaneous abortions. Chromosomal analysis of the mother of the patient showed a balanced karyotype of 46,XX,t(6;11) (q24; q21), whereas the chromosomes of her father were normal. The karyotype of this patient is thus a combination of a familial translocation 6;11 and a de novo translocation 4;11, which is very rare.
Eiben
B
B
Institut für Klinische Genetik und Zytologie am Evangelischen Krankenhaus, Oberhausen, Federal Republic of Germany.
Hammans
W
W
Hansen
S
S
D000328:Adult; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D007621:Karyotyping; D014178:Translocation, Genetic