title: Effects of estradiol and dexamethasone on choline acetyltransferase activity in various rat brain regions.
abstract: Estradiol, administered to ovariectomized rats, increased choline acetyltransferase (ChAT) activity in the caudate nucleus, cortex, hippocampus, and hypothalamus, suggesting possibly widespread central cholinergic involvement in estrus-related behavior. Dexamethasone also, except in hypothalamus, increased ChAT activity, notably (50%) in hippocampus. ChAT activity changes did not correlate with reported regional hormone receptor density. Estradiol's effect in the caudate suggests that hormone receptor and affected enzyme may not necessarily coexist intraneuronally.
authors.affiliation: Division of Molecular Biology and Neural Regeneration, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962.
authors.forename: H
authors.initials: H
authors.lastname: Kaufman
authors.forename: C
authors.initials: C
authors.lastname: Vadasz
authors.forename: A
authors.initials: A
authors.lastname: Lajtha
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002421:Caudate Nucleus / Q000187:drug effects / Q000201:enzymology; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D002799:Cholinergic Fibers / Q000187:drug effects / Q000201:enzymology*; D003907:Dexamethasone / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology; D007031:Hypothalamus / Q000187:drug effects / Q000201:enzymology; D010052:Ovariectomy; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004958:Estradiol; D003907:Dexamethasone; D002795:Choline O-Acetyltransferase