title: Comparison of sex hormone dependent induction of delta-aminolevulinic acid dehydratase in chick liver and oviduct.
abstract: 1. Comparative study on induction of hepatic and oviduct delta-aminolevulinic acid dehydratase (EC 4.2.1.24, ALAD) was performed following estradiol-17 beta and/or testosterone administration in immature female chicken (Gallus domesticus). 2. The lowest amount of estradiol for maximal induction of hepatic and oviduct ALAD activity was 2 mg/day/bird. 3. When estradiol of 2 mg/day/bird was administered for 15 days successively, induction extent of oviduct ALAD molecule was markedly larger and became approximately 144-fold in comparison with that of liver. Testosterone (2 mg/day/bird) alone did not induce both hepatic and oviduct ALAD activity. 4. Synergistic and antagonistic effect of testosterone on estradiol-induced total ALAD activity in oviduct was dependent on testosterone amount administered, whereas testosterone antagonized the inductive effect of estradiol on liver ALAD activity, independently of its amount.
authors.affiliation: Nippon Veterinary and Zootechnical College, Musashino, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Tsushima
authors.forename: M
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000818:Animals; D002645:Chickens; D004790:Enzyme Induction; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D010057:Oviducts / Q000187:drug effects / Q000201:enzymology*; D000623:Porphobilinogen Synthase / Q000096:biosynthesis*; D012016:Reference Values; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone; D004958:Estradiol; D000623:Porphobilinogen Synthase