Pseudo-random mating populations. In celebration of the 80th anniversary of the Hardy-Weinberg law.
That random mating leads to Hardy-Weinberg distribution of genotypes is well known. This report is to show that, if the deviations from random mating are of a certain pattern, the offspring generation will also be in Hardy-Weinberg proportions. This brings out the fact that random mating is a sufficient condition, not a necessary one, for the attainment of the Hardy-Weinberg proportions. Such nonrandom-mating populations are tentatively said to be pseudo-random mating. Pseudo-random-mating populations exist for both autosomal and sex-linked systems with two or multiple alleles. This report covers the basic case of a two-allele autosomal locus in detail, but the possible extension to two loci and cytonuclear systems have also been mentioned in discussion.
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Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261.
D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D011336:Probability