title: Variations in the disappearance rate of indocyanine green.
abstract: Time-associated changes in the disappearance rate of indocyanine green from the blood (K.ICG) as an index of liver function, were studied. Blood was drawn 5 times at 3-minute intervals from 32 patients. Early, intermediate, and late K.ICG values were 0.087 +/- 0.040, 0.082 +/- 0.038, and 0.076 +/- 0.033 min-1, respectively, showing serial decreases. When blood was drawn 8 times at 2-minute intervals from 22 other patients, the means of the K.ICG values at 11 time points showed a nearly linear relationship (r = -0.986). These findings indicated that K.ICG is approximated by a linear function of time, K(t) = -K'.t + K0. According to this function, K.ICG is considered to decrease by 1.96% every minute. The K.ICG value determined by the conventional method is, therefore, a mean disappearance rate of 15 minutes, and K0 is considered to reflect the initial reaction speed.
authors.affiliation: Department of Surgery, Tokyo Women's Medical College, Daini Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kumazawa
authors.forename: T
authors.initials: T
authors.lastname: Kikuchi
authors.forename: T
authors.initials: T
authors.lastname: Oishi
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
authors.forename: S
authors.initials: S
authors.lastname: Ohigashi
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Kajiwara
authors.forename: N
authors.initials: N
authors.lastname: Sakakibara
mesh_terms: D002779:Cholestasis / Q000175:diagnosis; D006801:Humans; D007208:Indocyanine Green / Q000097:blood / Q000493:pharmacokinetics*; D008103:Liver Cirrhosis / Q000175:diagnosis; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000175:diagnosis; D012044:Regression Analysis; D013997:Time Factors
chemical_list: D007208:Indocyanine Green