title: Low grade stage I and II non-Hodgkin's lymphoma: results of treatment and relapse pattern following therapy.
abstract: Sixty-four patients (37 stage I and 27 stage II) with low grade non-Hodgkin's lymphoma were treated by surgical excision alone (two patients) or with radiotherapy (53 patients), chemotherapy (five patients) or both (four patients). Actuarial survival was 80.7% at 5 years and 77.9% at 10 years. Actuarial recurrence-free survival at 10 years was 49.4% for stage I and 38.0% for stage II patients. Local control was achieved in 52 out of 56 (93%) patients treated with a radiation dose of 30 Gy or greater. There was no advantage for extended compared with involved, field irradiation. A multivariate analysis identified age, sex, stage and disease site as independent prognostic variables for survival.
authors.affiliation: Department of Clinical Oncology, Western General Hospital, Edinburgh.
authors.forename: R E
authors.initials: RE
authors.lastname: Taylor
authors.forename: S G
authors.initials: SG
authors.lastname: Allan
authors.forename: M A
authors.initials: MA
authors.lastname: McIntyre
authors.forename: G R
authors.initials: GR
authors.lastname: Kerr
authors.forename: A J
authors.initials: AJ
authors.lastname: Taylor
authors.forename: G L
authors.initials: GL
authors.lastname: Ritchie
authors.forename: R C
authors.initials: RC
authors.lastname: Leonard
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012606:Scotland