Prenatal diagnosis of a de novo unbalanced translocation (4p+) following in vitro fertilization.
We report herein a de novo unbalanced chromosome translocation in a fetus resulting from in vitro fertilization technology. Prenatal diagnostic analysis of an amniotic fluid revealed a 46,XX,4p+ karyotype. The origin of the extra material on the short arm of chromosome 4 could not be identified by a variety of banding techniques. However, examination of fetal parts did reveal some dysmorphic features.
Cannizzaro
L A
LA
Genetics Center, Southwest Biomedical Research Institute of Genetics and Cancer, Scottsdale, AZ 85251.
Hecht
B K
BK
Bixenman
H A
HA
Pazdziorko
S
S
Tamis
R
R
Hecht
F
F
D000328:Adult; D002869:Chromosome Aberrations / Q000175:diagnosis* / Q000209:etiology; D025063:Chromosome Disorders; D002894:Chromosomes, Human, Pair 4; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014178:Translocation, Genetic