title: Acute fulminating fatal leukoencephalopathy as the only manifestation of human immunodeficiency virus infection.
abstract: A case of acute human immunodeficiency virus (HIV) infection manifested by a rapidly fulminating, necrotizing, demyelinating encephalopathy that led to brain death in 5 days is reported. Autopsy demonstrated predominant white matter lesions, acute neuronal damage, and scanty cellular response. Cultures of cerebrospinal fluid were positive for HIV, suggesting an acute infection.
authors.affiliation: Department of Neurology, Lahey Clinic Medical Center, Burlington, MA 01805.
authors.forename: H R
authors.initials: HR
authors.lastname: Jones
authors.forename: D D
authors.initials: DD
authors.lastname: Ho
authors.forename: P
authors.initials: P
authors.lastname: Forgacs
authors.forename: L S
authors.initials: LS
authors.lastname: Adelman
authors.forename: M L
authors.initials: ML
authors.lastname: Silverman
authors.forename: R A
authors.initials: RA
authors.lastname: Baker
authors.forename: P
authors.initials: P
authors.lastname: Locuratolo
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid / Q000150:complications* / Q000401:mortality; D000328:Adult; D005260:Female; D006678:HIV / Q000302:isolation & purification; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000000981:diagnostic imaging / Q000209:etiology* / Q000382:microbiology / Q000401:mortality; D011859:Radiography