Urinary enzyme release following aminoglycoside administration in single low dose.
Urinary enzyme excretion was investigated in healthy volunteers before and after infusion of single low doses of aminoglycoside (gentamicin, tobramycin and amikacin) in the same subjects. Significant increases were detected in urinary leucine aminopeptidase, lactate dehydrogenase and alkaline phosphatase following gentamicin infusion; after amikacin administration only urinary release of leucine aminopeptidase was found to be increased. No difference was detected compared to basal values in enzyme excretion after tobramycin infusion. Urinary enzyme release in our conditions suggests low tubular damage after single doses of gentamicin and amikacin.
Emanuelli
G
G
Institute of Internal Medicine, Turin University, Italy.
Anfossi
G
G
Calcamuggi
G
G
Marcarino
C
C
Lanzio
M
M
D000328:Adult; D000469:Alkaline Phosphatase / Q000652:urine; D000583:Amikacin / Q000494:pharmacology; D000617:Aminoglycosides / Q000097:blood / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004798:Enzymes / Q000652:urine*; D005260:Female; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000652:urine; D007931:Leucyl Aminopeptidase / Q000652:urine; D008297:Male; D014031:Tobramycin / Q000494:pharmacology
D000617:Aminoglycosides; D004798:Enzymes; D005839:Gentamicins; D000583:Amikacin; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase; D007931:Leucyl Aminopeptidase; D014031:Tobramycin