Effect of interferon-alpha (IFN alpha) on various human tumor xenografts.
The growth of some human tumor xenografts (3 out of 8, melanoma, non-Hodgkin's lymphoma, squamous cell carcinoma) was successfully--but moderately and temporarily--inhibited, when interferon-alpha (EGIS, Hungary) was given for 10 days. The route of administration (intratumoral or intraperitoneal) was usually not a decisive factor. An attempt to potentiate IFNa action with Zymozan or Cyclophosphamide did not succeed.
Nagy
P
P
1st Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, Budapest, Hungary.
Kopper
L
L
Gyapay
G
G
Péterfy
F
F
Lapis
K
K
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004347:Drug Interactions; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008545:Melanoma / Q000188:drug therapy*; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous; D015054:Zymosan / Q000627:therapeutic use
D007370:Interferon Type I; D003520:Cyclophosphamide; D015054:Zymosan