title: The statistical analysis of treatment effects in 24-hour ambulatory blood pressure recordings.
abstract: This paper presents a statistical analysis of treatment effects in 24-hour ambulatory blood pressure recordings. The statistical models account for circadian rhythms, subject effects, and the effects of treatment with drugs or relaxation therapy. In view of the heterogeneity of the subjects, we fit a separate linear model to the data of each subject, use robust statistical procedures to estimate the parameters of the linear models, and trim the data on a subject by subject basis. We use a meta-analytical method to combine the results of all subjects in the study.
authors.affiliation: Department of Psychiatry, Cleveland Metropolitan General Hospital, OH 44102.
authors.forename: M R
authors.initials: MR
authors.lastname: Marler
authors.forename: R G
authors.initials: RG
authors.lastname: Jacob
authors.forename: J P
authors.initials: JP
authors.lastname: Lehoczky
authors.forename: A P
authors.initials: AP
authors.lastname: Shapiro
mesh_terms: D000204:Activity Cycles; D000553:Ambulatory Care; D001262:Atenolol / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination; D002752:Chlorthalidone / Q000627:therapeutic use; D002940:Circadian Rhythm; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy*; D008991:Monitoring, Physiologic; D012044:Regression Analysis; D012063:Relaxation; D013223:Statistics as Topic
chemical_list: D001262:Atenolol; D002752:Chlorthalidone