title: Abnormalities of functional residual capacity in symptomatic and asymptomatic young asthmatics.
abstract: Functional residual capacity (FRC) was measured by helium gas dilution in 186 young asthmatics, aged between 2 and 9 years. The majority were hyperinflated, as evidenced by an increase in FRC, regardless of symptom status. Symptomatic children and those hospitalized with an acute asthma attack had significantly elevated FRC when compared to asymptomatic children (p less than 0.01). Eight symptomatic children, following treatment modification, became asymptomatic. This was associated with a reduction in FRC. We suggest that an FRC result greater than one standard deviation from the mean of asymptomatic asthmatics could be used to predict inadequacy of treatment.
authors.affiliation: Department of Child Health, King's College Hospital, London, England.
authors.forename: J B
authors.initials: JB
authors.lastname: Pool
authors.forename: A
authors.initials: A
authors.lastname: Greenough
authors.forename: J F
authors.initials: JF
authors.lastname: Price
mesh_terms: D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005652:Functional Residual Capacity; D005740:Gases; D006371:Helium; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male
chemical_list: D005740:Gases; D006371:Helium