Limited efficacy of levamisole against adults of Dirofilaria immitis in a dog.
A dog with chronic dirofilariasis (Dirofilaria immitis) was given 15 doses of 12 or 24 mg of levamisole/kg of body weight in 6 treatments within 96 days. Concentration of microfilariae in the blood was determined before and after treatment, and Aedes triseriatus mosquitoes were fed on the dog 1 to 5 days after each treatment and examined for D immitis larvae. Several adult worms were recovered from the dog 160 days after the end of the treatments.
Barriga
O O
OO
Department of Veterinary Pathobiology, Ohio State University, Columbus 43210-1092.
Andujar
F
F
D000330:Aedes; D000818:Animals; D004183:Dirofilaria immitis / Q000187:drug effects / Q000254:growth & development; D004184:Dirofilariasis / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D006321:Heart / Q000469:parasitology; D007978:Levamisole / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008842:Microfilariae / Q000254:growth & development
D007978:Levamisole