title: Relationship between tracheal air flow and induced changes in intrathoracic volume. A basis for calibration of pneumocardiogram.
abstract: The volume of air moved into the trachea due to ventricular activity--a record of which is the pneumocardiogram (PNCG)--is always less than true stroke volume. A new method of investigating this relationship consists of inducing a known volume change (delta V in) within the thorax and measuring the volume of air (delta V out) recorded with a pneumotachograph connected to the trachea. The range of delta V in was from 4 ml to 36 ml. A linear relationship (mean r = 0.98, p less than 0.001) between delta V out and delta V in was observed in 19 anesthetized, intubated dogs: delta V out = (f) delta V in, where f = 0.53 +/- 0.09 (mean +/- SD). The coefficient, f, ranged from 0.40 to 0.71. These results demonstrate that although f is subject-dependent, delta V out reliably reflects changes in delta V in. It is suggested that the technique of inducing a known volume change within the thorax and measuring the volume of air recovered from the trachea could be used as a method for calibrating the pneumocardiogram to obtain stroke volume.
authors.affiliation: Hillenbrand Biomed. Eng. Cntr., Purdue University, West Lafayette, IN 47907.
authors.forename: J L
authors.initials: JL
authors.lastname: Wessale
authors.forename: J D
authors.initials: JD
authors.lastname: Bourland
authors.forename: L A
authors.initials: LA
authors.lastname: Geddes
mesh_terms: D000403:Airway Resistance; D000818:Animals; D002138:Calibration; D004285:Dogs; D004947:Esophagus / Q000502:physiology; D006334:Heart Function Tests / Q000295:instrumentation / Q000379:methods*; D012044:Regression Analysis; D012119:Respiration; D013318:Stroke Volume; D013909:Thorax / Q000502:physiology*; D014132:Trachea / Q000502:physiology*