Decreased skeletal muscle potassium in obesity.
The effect of body weight on total body potassium, skeletal muscle electrolytes and fat content was studied in seven lean and seven obese middle-aged men and seven lean and eight obese middle-aged women. Total body potassium and total body fat increased with body weight (p less than 0.01 and less than 0.05 for men, and p less than 0.05 and p less than 0.001 for women, respectively). So did muscle fat in men (p less than 0.01), while muscle tissue potassium was decreased in both obese men (p less than 0.001) and obese women (p less than 0.05). The skeletal muscle Na/K-ratio tended to be higher in obese men (p less than 0.1) but was not related to body weight in women. Skeletal muscle magnesium was higher (p less than 0.01) in obese men than in lean men. No differences between lean and obese women were found. Obese men had higher diastolic blood pressure (p less than 0.05) than lean men, while there was no difference between obese and lean women. Compared with lean subjects, obese subjects thus had lower relative skeletal muscle mass and men, especially, had more fat and less potassium in the skeletal muscle.
Landin
K
K
Department of Medicine, University of Lund, Malmö General Hospital, Sweden.
Lindgärde
F
F
Saltin
B
B
Wilhelmsen
L
L
D000273:Adipose Tissue / Q000033:anatomy & histology; D000328:Adult; D001794:Blood Pressure; D001835:Body Weight; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008274:Magnesium / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
D006442:Glycated Hemoglobin; D008274:Magnesium; D011188:Potassium; D012964:Sodium