Effect of hyperthermia on the frequency of sister-chromatid exchanges in patients with cancer of cervix uteri.
The frequencies of sister-chromatid exchanges (SCE) were studied in patients with cancer of the cervix uteri and normal controls at 37 degrees C and 40 degrees C. At 37 degrees C the mean frequency of SCE was found to be 8.26 +/- 1.91 in untreated patients with cervical cancer and 7.91 +/- 1.68 in cancer patients treated with radiotherapy; these values were significantly higher than the control value of 5.34 +/- 1.28 exchanges. Increase of the growth temperature to 40 degrees C elevated the SCE frequency to 11.95 +/- 2.12 in patients without radiotherapy treatment, 13.37 +/- 2.17 in patients with radiotherapy treatment and 7.82 +/- 1.84 in normal controls. These data indicate that there is a differential induction of SCEs by hyperthermia in the lymphocytes of control women and patients with cancer of the cervix uteri.
Ghosh
P K
PK
Department of Anthropology, University of Delhi, India.
Ghosh
R
R
D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005260:Female; D006358:Hot Temperature; D006801:Humans; D008214:Lymphocytes / Q000166:cytology; D008875:Middle Aged; D012854:Sister Chromatid Exchange; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000532:radiotherapy; D014965:X-Rays