Mobilization of stored hexachlorobenzene and p,p-dichlorodiphenyldichloroethylene during partial starvation in rats.
Hexachlorobenzene (HCB) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) kinetics were compared in rats before, during and after partial starvation. Food restriction produced a drastic mobilization of the residues stored in the adipose tissue resulting in symptoms of neurotoxicity. The redistribution was reversible and did not produce a significant reduction in the chemicals body burden. HCB and p,p'-DDE, although both highly lipophilic, showed important differences in their blood transport and distribution pattern, with more HCB being transported by red blood cells and with a greater facility for HCB to reach the liver and the brain.
To-Figueras
J
J
Department of Toxicology, Hospital Clínic, Facultat de Medicina, Universitat de Barcelona, Spain.
Gómez-Catalán
J
J
Rodamilans
M
M
Corbella
J
J
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D001835:Body Weight; D002722:Chlorobenzenes / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D005260:Female; D006581:Hexachlorobenzene / Q000097:blood / Q000378:metabolism*; D008053:Lipid Mobilization; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism*; D014018:Tissue Distribution
D002722:Chlorobenzenes; D006581:Hexachlorobenzene