Bicycle ergometer and echocardiographic study in healthy subjects and patients with angina pectoris after administration of L-carnitine: semiautomatic computerized analysis of M-mode tracing.
The discovery tha carnitine takes an active part in the transportation of long-chain acyl residues across the inner mitochondrial membrane dates back to 1958. It has been shown experimentally tha a reduction in myocardial carnitine content takes place after 15-30 min of ischemia. L-carnitine was administered orally in doses of 3 g/day for 30 days to 16 subjects with effort-induced angina and to 14 healthy subjects. A bicycle ergometer exercise test revealed a 1.5 mm (mean) depression of the ST-T segment in the angina subjects after pharmacological wash-out and a 1 mm depression in the same subjects after carnitine treatment. M-code echocardiography showed positive changes in a number of ventricular function parameters in the angina subjects and also, to a lesser extent, in the healthy controls.
Canale
C
C
Institute of Cardiovascular Diseases, University of Genoa, Italy.
Terrachini
V
V
Biagini
A
A
Vallebona
A
A
Masperone
M A
MA
Valice
S
S
Castellano
A
A
D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D002331:Carnitine / Q000008:administration & dosage / Q000172:deficiency*; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D002331:Carnitine