title: Deoxycorticosterone secretion by the human ovary.
abstract: Progesterone (P), deoxycorticosterone (DOC), estradiol-17 beta (E2) and cortisol (F) were determined simultaneously in the peripheral and the ovarian veins in 13 patients. Blood was collected either by direct sampling during laparotomy (12 patients) or by selective catheterization (1 patient). In all ovarian effluents P and E2 levels were significantly higher than in the peripheral vein. This was also true for DOC except in one ovarian effluent. The gradient was higher on the side of the corpus luteum-bearing ovary. P and E2 levels were correlated in ovarian as well as in peripheral veins. In ovarian effluents, DOC gradients were only significantly correlated with P levels (r = 0.63; P less than 0.01) suggesting a metabolic relationship between the two steroids.
authors.affiliation: Fondation de Recherche en Hormonologie, Fresnes, France.
authors.forename: K
authors.initials: K
authors.lastname: Nahoul
authors.forename: L
authors.initials: L
authors.lastname: Dehennin
authors.forename: J
authors.initials: J
authors.lastname: Salat-Baroux
authors.forename: R
authors.initials: R
authors.lastname: Scholler
mesh_terms: D000328:Adult; D003900:Desoxycorticosterone / Q000378:metabolism*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008875:Middle Aged; D010053:Ovary / Q000098:blood supply / Q000378:metabolism*; D011374:Progesterone / Q000097:blood
chemical_list: D003900:Desoxycorticosterone; D011374:Progesterone; D004958:Estradiol; D006854:Hydrocortisone