Isolated jejunal pouches for levodopa delivery in parkinsonian patients with "on-off". Successful experimental model in dogs.
In eight dogs, a 20 cm section of isolated jejunum with intact blood supply was externalized to the abdominal wall and used as a device for levodopa (LD) administration. Overall, Sinemet tablets and LD suspension produced similar plasma levodopa concentrations with oral and pouch administration. The most ideal plasma concentration curves were obtained for CR-3, a sustained release Sinemet preparation, given through the jejunal pouches. Plasma LD concentrations rose within the first hour after administration of CR-3 and remained constant for the next 3 h, before falling slowly. Isolated jejunal pouches may therefore be an effective, simple means of maintaining constant plasma LD concentrations in parkinsonian patients with motor fluctuations and may diminish the deleterious effects of erratic gastric emptying and competition with food-derived amino acids at the gut/blood transport system.
Sage
J I
JI
Department of Neurology, UMDNJ--Robert Wood Johnson Medical School, New Brunswick 08903.
Trooskin
S
S
Schuh
L
L
Duncsak
P
P
Sonsalla
P K
PK
Heikkila
R E
RE
Manzino
L
L
Reddell
M
M
Duvoisin
R C
RC
D000818:Animals; D004044:Dietary Proteins / Q000378:metabolism; D004285:Dogs; D004343:Drug Implants; D007583:Jejunum / Q000502:physiology*; D007980:Levodopa / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D010300:Parkinson Disease / Q000188:drug therapy*; D013607:Tablets
D004044:Dietary Proteins; D004343:Drug Implants; D013607:Tablets; D007980:Levodopa