Rat c-raf oncogene is located on chromosome 4 and may be activated by sequences from chromosome 13.
Activated forms of the protooncogene c-raf have been found to transform established lines of rodent fibroblasts after transfection with DNA from several human and rat tumors. Using Southern blot analysis of DNAs from rat x mouse somatic cell hybrids, we have mapped c-raf to rat chromosome 4. An exogenous sequence that was found juxtaposed to c-raf within transforming DNA originally derived from a rat hepatocellular carcinoma was localized to chromosome 13.
Ingvarsson
S
S
Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
Asker
C
C
Szpirer
J
J
Levan
G
G
Klein
G
G
D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D006822:Hybrid Cells; D051379:Mice; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes; D051381:Rats; D014162:Transfection