title: Mechanism of decreased forward stroke volume in children and swine with ventricular septal defect and failure to thrive.
abstract: Children with ventricular septal defect (VSD) often demonstrate failure to thrive (FTT). Such patients usually have reduced systemic cardiac output which has been postulated as a cause for their growth retardation. This study was conducted to ascertain the mechanism of the reduced cardiac output in children with VSD and FTT and also in a porcine model of VSD. Forward stroke volume was reduced in VSD-FTT children, 31 +/- 8 ml/m2, compared to normal children, 49 +/- 15 ml/m2 (P less than 0.05), but was not reduced in children with VSD and normal growth and development (41 +/- 16 ml/m2). Forward stroke volume was also reduced in swine with VSD compared to controls. Contractility assessed by mean velocity of circumferential shortening (Vcf) corrected for afterload was similar in normals and VSD-FTT children. Contractile performance was also similar in normal and VSD swine. Afterload assessed as systolic stress was similar in FTT-VSD children and normal subjects. Preload assessed as end-diastolic stress was increased in the VSD-FTT group. End-diastolic volume was not larger in the VSD-FTT group. We conclude that the reduced stroke volume seen in VSD-FTT children and VSD-swine was not due to reduced contractility, increased afterload or reduced preload. The reduced stroke volume may have been due to failure of end-diastolic volume to increase adequately.
authors.affiliation: Division of Cardiology, Medical University of South Carolina, Charleston 29425.
authors.forename: W J
authors.initials: WJ
authors.lastname: Corin
authors.forename: M M
authors.initials: MM
authors.lastname: Swindle
authors.forename: J F
authors.initials: JF
authors.lastname: Spann
authors.forename: K
authors.initials: K
authors.lastname: Nakano
authors.forename: M
authors.initials: M
authors.lastname: Frankis
authors.forename: R W
authors.initials: RW
authors.lastname: Biederman
authors.forename: A
authors.initials: A
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Taylor
authors.forename: B A
authors.initials: BA
authors.lastname: Carabello
mesh_terms: D000818:Animals; D006328:Cardiac Catheterization; D002648:Child; D002675:Child, Preschool; D002932:Cineangiography; D005183:Failure to Thrive / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D008297:Male; D009200:Myocardial Contraction; D011184:Postoperative Period; D013318:Stroke Volume; D013552:Swine; D013556:Swine, Miniature