title: Ventricular septal defect with overriding aorta in trisomy-18.
abstract: In a child with trisomy-18 prenatal echocardiography demonstrated the presence of a ventricular septal defect with overriding aorta. In a previous anatomical study of 18 hearts with this malformation we found a 50% concurrence rate with trisomy-18. In case of prenatal echocardiographic detection of a ventricular septal defect with overriding aorta, we advise thorough ultrasound examination for additional malformations as seen in trisomy-18; subsequently this procedure should be completed by cytogenetic analysis of amniotic cells.
authors.affiliation: Department of Paediatric Cardiology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Moene
authors.forename: M
authors.initials: M
authors.lastname: Sobotka-Plojhar
authors.forename: A
authors.initials: A
authors.lastname: Oppenheimer-Dekker
authors.forename: D
authors.initials: D
authors.lastname: Lindhout
mesh_terms: D001011:Aorta / Q000002:abnormalities*; D002887:Chromosomes, Human, Pair 18; D004452:Echocardiography; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D011296:Prenatal Diagnosis; D014314:Trisomy