Plasma tetranectin is reduced in cancer and related to metastasia.
Tetranectin, a recently identified and characterized human plasma protein related to the fibrinolytic system, was significantly reduced in patients with various malignancies. Plasma tetranectin, measured by enzyme-linked immunosorbent assay (ELISA), was a significant discriminator regarding metastatic or nonmetastatic cancer. It had a high predictive specificity (0.93) and sensitivity (0.75) and only misclassified 14% of patients. Tetranectin may be related to the pathogenetically important processes leading to cancer spread and metastasis. In this respect, it may prove to be of discriminative importance clinically.
Jensen
B A
BA
Department of Clinical Immunology, Hvidovre Hospital, University of Copenhagen, Hvidovre.
Clemmensen
I
I
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001798:Blood Proteins; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D037181:Lectins, C-Type; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000097:blood*
D001798:Blood Proteins; D037181:Lectins, C-Type; C048648:tetranectin