Influence of renal function on the elimination of morphine and morphine glucuronides.
The influence of renal function, measured by 51Cr-EDTA clearance, on morphine and morphine glucuronide kinetics has been studied in 13 patients after a single i.v. injection of morphine. Unconjugated morphine and morphine glucuronides were measured by a sensitive, specific RIA after extraction from plasma. No significant correlation was found between total body clearance of unconjugated morphine and 51Cr-EDTA clearance. However, patients with renal insufficiency had impaired elimination of morphine glucuronides, and the apparent clearance was significantly correlated with the 51Cr-EDTA clearance (r = 0.94, p less than 0.001). A relatively long terminal elimination of half-life of morphine was found in all patients (mean +/- SD: 9.2 +/- 2.5 h), irrespective of glomerular function.
Wolff
J
J
Department of Anaesthesia, Bispebjerg Hospital, Copenhagen, Denmark.
Bigler
D
D
Christensen
C B
CB
Rasmussen
S N
SN
Andersen
H B
HB
Tønnesen
K H
KH
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005919:Glomerular Filtration Rate; D005965:Glucuronates / Q000378:metabolism; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics
D005965:Glucuronates; D009020:Morphine