Interaction of propranolol with GABA stimulated diazepam binding to rat brain membranes.
1. In the case of an intraperitoneal propranolol injection to rats (25 mg/kg), there was no modification in benzodiazepine and gamma-amino-butyric acid recognition sites since [3H]diazepam or [3H]-muscimol binding was not affected. 2. There was an increase in GABA stimulated-diazepam binding (100%, statistical risk lower than 1%). 3. This last result suggests that propranolol treatment can stimulate GABA-benzodiazepine receptor coupling.
Benistant
C
C
Unité INSERM 205 Laboratoire de Chimie Biologique, Institut National des Sciences Appliquées, Villeurbanne, France.
Rey
C
C
Fonlupt
P
P
Pacheco
H
H
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism*; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid; D011433:Propranolol; D003975:Diazepam