title: [Effects of hypobaric-hypoxia on the total number and histochemical properties of the soleus muscle fibers and motoneurons in the rat].
abstract: After 7 weeks of hypobaric-hypoxia adaptation, horseradish peroxidase was injected into the soleus muscle to label motoneurons of the spinal cord in rats. Fiber type distribution in the soleus muscle and oxidative enzyme activity of motoneurons innervating the soleus muscle were examined. Fiber type was converted from slow-twitch-oxidative (SO) to fast-twitch-oxidative-glycolytic (FOG). Oxidative enzyme activity of motoneurons (25-45 micron soma diameter) was increased. However, oxidative capacity of larger motoneurons (greater than or equal to 45 micron soma diameter) was not changed. These data suggest that the lack of increase in oxidative capacity of larger motoneurons (innervating SO units) by hypoxia secondarily causes fiber type shift from SO to FOG.
authors.affiliation: Faculty of Education, Kobe University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: S
authors.initials: S
authors.lastname: Taguchi
authors.forename: A
authors.initials: A
authors.lastname: Ishihara
mesh_terms: D000818:Animals; D001274:Atmospheric Pressure; D000860:Hypoxia / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009046:Motor Neurons / Q000378:metabolism / Q000473:pathology*; D009132:Muscles / Q000378:metabolism / Q000473:pathology*; D010101:Oxygen Consumption; D051381:Rats; D011919:Rats, Inbred Strains