title: [Update on paraneoplastic hypercalcemia. Our experience in the treatment of hypercalcemic states of patients with advanced breast carcinoma].
abstract: The treatment of hypercalcemia of malignancy is troublesome. Personal experience with breast cancer associated hypercalcemia is presented. Eight patients were hydrated with intravenous administration of saline solution containing high doses of salmon calcitonin and subsequently six were treated with antiblastic polychemotherapy. Calcium level fell to normal in all patients. Hypercalcemia, with or without evidence of metastatic bone disease, may be caused by the production of humoral substance by tumoral tissue. In our experience the first therapeutic stage is the infusion of saline solution containing high doses of calcitonin, while the elective treatment is antiblastic polychemotherapy which, acting on tumour growth, may inhibit the release of humoral mediators of hypercalcemia causing a slower but stable reduction in serum calcium level.
authors.affiliation: III Divisione di Medicina Generale, Spedali Civili, Brescia.
authors.forename: A
authors.initials: A
authors.lastname: Grottolo
authors.forename: V
authors.initials: V
authors.lastname: Ferrari
authors.forename: R
authors.initials: R
authors.lastname: Lazzari
authors.forename: M R
authors.initials: MR
authors.lastname: Mariano
authors.forename: A
authors.initials: A
authors.lastname: Zambruni
authors.forename: A
authors.initials: A
authors.lastname: Zaniboni
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D002116:Calcitonin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy* / Q000378:metabolism; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D002116:Calcitonin
vernacular_title: Attualità in tema di ipercalcemia paraneoplastica. La nostra esperienza nel trattamento degli stati ipercalcemici delle pazienti con carcinoma mammario avanzato.