Prostaglandin cytoprotection in man: effectiveness of rosaprostol.
We studied the effect of a new prostaglandin analogue, 9-hydroxy-19,20-bis-norprostanoic acid (rosaprostol), on the duodenal mucosa of humans after administration of 40% ethanol. Eighteen healthy volunteers entered the study, which followed a blind cross-over design. At time 0 all the volunteers received rosaprostol or placebo; 5 minutes later, 40% ethanol (50 ml dose) was given. The mucosa was examined for lesions 3, 60 and 180 min later under endoscopy, light and scanning microscopy. It was found that: (i) 40% ethanol damaged the duodenum, with blood extravasation, inflammation and necrosis of the mucosa, (ii) rosaprostol significantly protected the mucosa 3 min after 40% ethanol, and (iii) the damage became worse after 3 h when placebo was given, whereas it was reduced after 1 h when PG was administered. The results suggest that PGs not only protect the mucosa against ethanol damage, but also stimulate its recovery.
Foschi
D
D
Institute of Biomedical Sciences, L. Sacco, University of Milan, Italy.
Trabucchi
E
E
Galeone
M
M
Ferrante
F
F
Toti
G L
GL
Castoldi
L
L
Musazzi
M
M
Centemero
A
A
Montorsi
W
W
D000293:Adolescent; D000328:Adult; D004386:Duodenum / Q000187:drug effects / Q000473:pathology; D000431:Ethanol / Q000494:pharmacology; D005227:Fatty Acids / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008855:Microscopy, Electron, Scanning; D011465:Prostaglandins, Synthetic / Q000494:pharmacology*; D011466:Prostanoic Acids / Q000494:pharmacology*; D013997:Time Factors
D005227:Fatty Acids; D011465:Prostaglandins, Synthetic; D011466:Prostanoic Acids; D000431:Ethanol; C035288:rosaprostol