The role of the ventromedial thalamic nucleus in the catalepsy evoked from the substantia nigra pars reticulata in rats.
Picrotoxin (25, 50 and 100 ng), injected unilaterally into the posterior part of the substantia nigra pars reticulata (SNR) of rats, evoked a dose-dependent catalepsy. The catalepsy evoked by 100 ng of picrotoxin injected into the SNR was abolished by a subsequent bilateral injection of the same drug (200 ng) into the ventromedial thalamic nuclei. It is suggested that impulses pertinent to the catalepsy evoked from the SNR are transmitted via a GABAergic pathway to the ventromedial thalamic nucleus, wherefrom they reach the striatum, as had been shown previously.
Kolasiewicz
W
W
Department of Neuropharmacology, Polish Academy of Sciences, Kraków.
Wolfarth
S
S
Ossowska
K
K
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008845:Microinjections; D010852:Picrotoxin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects / Q000503:physiopathology*; D013787:Thalamic Nuclei / Q000187:drug effects / Q000503:physiopathology*
D010852:Picrotoxin