Fosfomycin versus ampicillin in the treatment of acute pyelonephritis.
In a controlled open study of 38 patients with acute pyelonephritis, treatment with fosfomycin 8 g b.i.d. was compared to treatment with ampicillin 2 g t.i.d., both for one week. The most common pathogen in both groups was Escherichia coli, susceptible to fosfomycin. However, 17% were resistant to ampicillin. The success rate was 44% in the fosfomycin treated group and 28% in the ampicillin group. The difference was not significant (p greater than 0.20). Peak concentrations of fosfomycin in serum were 395 mg/l and in tissue fluid 85 mg/l. Urine concentrations ranged from 6990 to 24,320 mg/l.
Ode
B
B
Department of Infectious Diseases, University of Lund, Malmö General Hospital, Sweden.
Haidl
S
S
Hoffstedt
B
B
Walder
M
M
Ursing
J
J
D000208:Acute Disease; D000667:Ampicillin / Q000627:therapeutic use*; D005578:Fosfomycin / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D011704:Pyelonephritis / Q000188:drug therapy*; D011897:Random Allocation
D005578:Fosfomycin; D000667:Ampicillin