title: Synthesis of nucleic acid methylphosphonothioates.
abstract: The reagent obtained in situ by treating methylphosphonothioic dichloride with 1-hydroxy-6-trifluoromethylbenzotriazole could be used for the introduction of methylphosphonothioate linkages. The individual diastereomers of the protected dimer d-Tp(S,Me)A were applied in the synthesis of the chiral pure (R or S) hexamers d-[CpCpTp(S,Me)ApGpG]. The reagent showed also to be very effective for the preparation of the 3',5'-cyclic methylphosphonothioate of uridine.
authors.affiliation: Gorlaeus Laboratory, Leiden, The Netherlands.
authors.forename: H C
authors.initials: HC
authors.lastname: Roelen
authors.forename: E
authors.initials: E
authors.lastname: de Vroom
authors.forename: G A
authors.initials: GA
authors.lastname: van der Marel
authors.forename: J H
authors.initials: JH
authors.lastname: van Boom
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D009696:Nucleic Acids; D009712:Nucleotides, Cyclic; D009946:Organothiophosphorus Compounds; D014500:Uracil Nucleotides
chemical_list: D009696:Nucleic Acids; D009712:Nucleotides, Cyclic; D009946:Organothiophosphorus Compounds; D014500:Uracil Nucleotides