title: Effect of acetylhomocysteine thiolactone on nucleolar cytology and lipofuscinogenesis in electric lobe neurons.
abstract: Treatment with acetylhomocysteine thiolactone significantly reduces the cellular level of lipofuscin in neurons of the electric lobe of Torpedo marmorata. At the same time, this drug produces a 45% decrease in nucleolar volume in these neurons, reflecting decreased cellular synthetic activity.
authors.affiliation: Department of Biology, Concordia University, Montreal, Quebec, Canada.
authors.forename: H E
authors.initials: HE
authors.lastname: Enesco
authors.forename: M A
authors.initials: MA
authors.lastname: Enesco
authors.forename: E
authors.initials: E
authors.lastname: Aloj Totaro
authors.forename: F A
authors.initials: FA
authors.lastname: Pisanti
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects* / Q000648:ultrastructure; D004557:Electric Organ / Q000187:drug effects / Q000648:ultrastructure; D008062:Lipofuscin / Q000378:metabolism*; D010860:Pigments, Biological / Q000378:metabolism*; D013876:Thiophenes / Q000494:pharmacology*; D014101:Torpedo
chemical_list: D008062:Lipofuscin; D010860:Pigments, Biological; D013876:Thiophenes; C000486:citiolone