Carcinogenic property of JBO(P) variety of jute batching oil.
The topical application of neat JBO-P variety of jute batching oil (JBO) three times a week has been found to produce skin tumours locally with 13 weeks of treatment on Swiss albino mice. In another set of experiments, 3 times/week topical application of JBO on Swiss albino mouse skin previously initiated (s.c., 1 mg/g body wt.) with urethane resulted in induction of tumours (squamous cell papillomas and keratoacanthomas) in 8 weeks. These results suggest that the JBO-P variety of jute batching oil could be a complete carcinogen or a tumour promoting substance on mouse skin.
Mehrotra
N K
NK
Industrial Toxicology Research Centre, Lucknow, India.
Kumar
S
S
Antony
M
M
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D005260:Female; D007636:Keratoacanthoma / Q000139:chemically induced; D051379:Mice; D008899:Mineral Oil / Q000633:toxicity*; D010212:Papilloma / Q000139:chemically induced; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced*
D002273:Carcinogens; C051384:jute batching oil; D001564:Benzo(a)pyrene; D008899:Mineral Oil