[Analysis of the physico-chemical properties of fluorocarbon inducers of cytochrome P-450 in membranes of liver endoplasmic reticulum].
Cytochrome P-450 induction in rat liver microsomes after intravenous injections of submicrone emulsions of nine perfluorochemicals (2 g of PFC per kg of body weight) was investigated. A comparison of physico-chemical properties of the fluorocarbons revealed that their activity as cytochrome P-450 inducers is determined by their solubility in H2O and lipids as well as by the pressure of their saturated vapours at 37 degrees C. The fluorocarbons capable of inducing cytochrome P-450 have a molecular mass of 400-550 Da. The presence of heteroatoms (N and O) and some structural peculiarities of the perfluorochemicals do not influence the ability of the fluorocarbons to induce cytochrome P-450.
Obraztsov
V V
VV
Shekhtman
D G
DG
Sklifas
A N
AN
Makarov
K N
KN
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004721:Endoplasmic Reticulum / Q000201:enzymology*; D004790:Enzyme Induction; D005466:Fluorocarbons / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility
D005466:Fluorocarbons; D003577:Cytochrome P-450 Enzyme System
Analiz fiziko-khimicheskikh svoĭstv ftoruglerodnykh induktorov tsitokhroma P-450 v membranakh éndoplazmaticheskogo retikuluma pecheni.