[Postradiation changes in count and contact properties of neutrophilic granulocytes of the bone marrow in short-term culture].
A study was made of adherence to plastic Petri dishes and viability (as non-pyknotic cell counts) of rat bone marrow cells cultured for 5 to 22 h in 199 medium containing 15 per cent fresh isologous serum. An overall decrease in the number of viable myelokaryocytes, including mature neutrophils, was observed in the cultures irradiated with doses of 3 to 12 Gy. In addition, gamma-irradiation increased substantially the adherence of neutrophils and, to a lesser extent, of other myelokaryocytes. A possibility of early radiation-induced disturbances in granulocytic maturation is discussed.
Chukhlovin
A B
AB
Nikolaeskaia
L V
LV
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D001854:Bone Marrow Cells; D002448:Cell Adhesion / Q000528:radiation effects; D002450:Cell Communication / Q000528:radiation effects*; D002452:Cell Count / Q000528:radiation effects; D002478:Cells, Cultured; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008297:Male; D009504:Neutrophils / Q000528:radiation effects*; D051381:Rats; D013997:Time Factors
Postradiatsionnye izmeneniia soderzhaniia i kontaktnykh svoĭstv neĭtrofil'nykh granulotsitov kostnogo mozga pri kratkosrochnom kul'tivirovanii.