Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes.
Diastereomeric para-substituted dichloro(1,2-diphenylethylenediamine)platinum(II) complexes were synthesized and tested for their antitumor activity on the human MDA-MB 231 breast cancer cell line and the P 388 leukemia of the mouse. An interaction with the DNA was demonstrated by UV difference spectroscopy. The D,L configurated, 4-fluoro-substituted complex was the most active.
Jennerwein
M
M
Institut für Pharmazie, Lehrstuhl Pharmazeutische Chemie II, Regensburg, Federal Republic of Germany.
Wappes
B
B
Gust
R
R
Schönenberger
H
H
Engel
J
J
Seeber
S
S
Osieka
R
R
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D002460:Cell Line; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388 / Q000473:pathology; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds