title: Effect of immobilization stress on tricyclic antidepressant binding and serotonin uptake in rats.
abstract: Immobilization stress increased the density of imipramine binding sites in platelet and cortical membranes and there was an increased serotonin uptake in platelets. There was a decrease in desipramine binding and noradrenaline uptake in lymphocytes. Our results show that stress acts on the mediator systems in various ways.
authors.affiliation: Psychiatric Research Unit, Faculty of Medicine, Charles University, Praha, Czechoslovakia.
authors.forename: I
authors.initials: I
authors.lastname: Farská
authors.forename: R
authors.initials: R
authors.lastname: Krulík
authors.forename: D
authors.initials: D
authors.lastname: Slíva
mesh_terms: D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003891:Desipramine / Q000378:metabolism; D004082:Dihydroalprenolol; D007099:Imipramine / Q000378:metabolism; D007700:Kinetics; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D012701:Serotonin; D004082:Dihydroalprenolol; D007099:Imipramine; D003891:Desipramine; D009638:Norepinephrine