title: Interstitial thermoradiotherapy for recurrent or persistent tumours.
abstract: Between 1984 and 1986, 31 sites in 27 patients with biopsy proven tumours were treated with a combination of interstitial microwave hyperthermia (HT) and iridium 192 implants (RT). The 31 sites treated included fifteen (48 per cent) head and neck, six (20 per cent) breast, four (13 per cent) vagina and cervix, and six (20 per cent) others. All patients had prior surgery, RT, or chemotherapy. Of the 31 sites treated, 19 (61 per cent) had complete response (CR) with no recurrence in the volume treated. Additionally, eight patients remained free of tumour from 3 to 24 months. Partial response (PR) was seen in 11 (36 per cent) sites while one (3 per cent) had lesser degree tumour regression. Tumour control rate correlated well with the dose of radiation, p = 0.02, and tumour volume, p = 0.02, but not with thermal dose. Treatment complications of significance occurred in one (3 per cent) site, which developed soft tissue necrosis. This study again has demonstrated the effectiveness of RT-HT combination in treatment of recurrent tumours.
authors.affiliation: Department of Radiation Oncology, University of Southern California School of Medicine, Los Angeles 90033.
authors.forename: K
authors.initials: K
authors.lastname: Lam
authors.forename: M
authors.initials: M
authors.lastname: Astrahan
authors.forename: B
authors.initials: B
authors.lastname: Langholz
authors.forename: J
authors.initials: J
authors.lastname: Jepson
authors.forename: D
authors.initials: D
authors.lastname: Cohen
authors.forename: G
authors.initials: G
authors.lastname: Luxton
authors.forename: Z
authors.initials: Z
authors.lastname: Petrovich
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced; D007495:Iridium / Q000627:therapeutic use; D008297:Male; D008872:Microwaves / Q000627:therapeutic use; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local
chemical_list: D007495:Iridium