title: Long-term ingestion of ammonium inhibits lysosomal proteolysis in rat liver.
abstract: A standard diet was supplemented with ammonium acetate (20%, w/w). The effect on liver protein degradation of oral administration of the ammonium diet to rats for 6 weeks has been studied. It is shown that lysosomal proteolysis is markedly decreased (by 62%) while non-lysosomal proteolysis is inhibited by 11%. This is the first report showing that ammonium ingestion inhibits liver proteolysis.
authors.affiliation: Instituto de Investigaciones Citológicas de la Caja de Ahorros de Valencia, Centro Asociado del CSIC, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Felipo
authors.forename: M D
authors.initials: MD
authors.lastname: Miñana
authors.forename: R
authors.initials: R
authors.lastname: Wallace
authors.forename: S
authors.initials: S
authors.lastname: Grisolía
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D008099:Liver / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D011480:Protease Inhibitors; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000085:Acetates; D011480:Protease Inhibitors; D011506:Proteins; C018824:ammonium acetate