title: Effects of fluocinolone acetonide on mouse skin sterol metabolism and two-stage carcinogenesis.
abstract: Fluocinolone acetonide (FA) is one of the most potent synthetic glucocorticoids and is known to possess an anti-tumor promoting activity. An attempt was made to evaluate this activity by estimating tumor promoting activity. Unexpectedly, when 10 micrograms of FA was applied alone or after a single application of a subcarcinogenic dose of 3-methylcholanthrene to mouse skin, results suggested that FA itself may be a tumor promoter or a complete carcinogen. Other glucocorticoids tested, e.g. dexamethasone, hydrocortisone and prednisolone, also revealed similar effects but were less potent than FA. To verify the possibility that glucocorticoid is a complete carcinogen or a tumor promoter, a tumor incidence experiment was performed for 24 weeks. As a result it was found that FA possesses a tumor promoting activity at some dose levels but no tumor initiating activity.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hiroshima University, School of Dentistry, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Fukao
authors.forename: Y
authors.initials: Y
authors.lastname: Tanimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kayata
authors.forename: K
authors.initials: K
authors.lastname: Yoshiga
authors.forename: K
authors.initials: K
authors.lastname: Takada
authors.forename: K
authors.initials: K
authors.lastname: Okuda
mesh_terms: D000818:Animals; D002849:Chromatography, Gas; D004305:Dose-Response Relationship, Drug; D005446:Fluocinolone Acetonide / Q000494:pharmacology*; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D012867:Skin / Q000378:metabolism*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D013261:Sterols / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D013261:Sterols; D005446:Fluocinolone Acetonide; D008748:Methylcholanthrene; D013755:Tetradecanoylphorbol Acetate