title: Synthesis of prostaglandin E by peritoneal macrophages from NZB/W mice.
abstract: Peritoneal macrophages from NZB/W (murine lupus) mice spontaneously produce less prostaglandin E (PGE) than peritoneal macrophages from immunologically normal mice. Reduced PGE synthesis is seen as early as 2 months of age and becomes more profound as disease progresses. It is suggested that impaired production of PGE by peritoneal macrophages from NZB/W mice may account in part for abnormal macrophage function observed in these animals.
authors.affiliation: Department of Neurology, University of Connecticut Health Center, Farmington 06032.
authors.forename: P
authors.initials: P
authors.lastname: Dore-Duffy
authors.forename: A
authors.initials: A
authors.lastname: Guha
authors.forename: B L
authors.initials: BL
authors.lastname: Rothman
authors.forename: R B
authors.initials: RB
authors.lastname: Zurier
mesh_terms: D000367:Age Factors; D000818:Animals; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008814:Mice, Inbred NZB; D009393:Nephritis / Q000378:metabolism; D010529:Peritoneal Cavity / Q000166:cytology; D011458:Prostaglandins E / Q000096:biosynthesis*
chemical_list: D011458:Prostaglandins E