Ferritin H and L mRNAs in human neoplastic tissues.
The typical tissue isoferritin pattern varies during neoplastic transformation, usually shifting toward a more acidic profile. To investigate the molecular basis of this phenomenon, we have analyzed the steady-state levels of the H and L mRNAs in several neoplastic tissues. By using specific probes for the two ferritin subunits, we have found, in three different adenocarcinomas and in a case of Hodgkin lymphoma, a two- to four-fold increase of the H and L mRNA levels compared to those found in normal human liver.
Bevilacqua
M A
MA
Istituto di Scienze Biochimiche, II Facoltà di Medicina e Chirurgia, Università di Napoli.
Costanzo
F
F
Buonaguro
L
L
Cimino
F
F
D000230:Adenocarcinoma / Q000032:analysis; D003110:Colonic Neoplasms / Q000032:analysis; D005293:Ferritins / Q000235:genetics*; D006689:Hodgkin Disease / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D008113:Liver Neoplasms / Q000032:analysis; D009369:Neoplasms / Q000032:analysis*; D012333:RNA, Messenger / Q000032:analysis*; D013274:Stomach Neoplasms / Q000032:analysis
D012333:RNA, Messenger; D005293:Ferritins