Effect of ivermectin against subperiodic Brugia malayi infection in the leaf monkey, Presbytis cristata.
Ivermectin at single doses of 0.2-1.0 mg/kg body weight reduced the microfilarial counts of subperiodic Brugia malayi in Presbytis cristata by 59.9%-89.6% of initial counts, 4 weeks after treatment. Adult filaricidal activity was poor, live adult worms being recovered from all animals at autopsy. There was no serious side effect at these doses.
Mak
J W
JW
Institute for Medical Research, Kuala Lumpur, Malaysia.
Lam
P L
PL
Rain
A N
AN
Suresh
K
K
D000284:Administration, Oral; D000818:Animals; D002009:Brugia / Q000187:drug effects; D002520:Cercopithecidae; D004605:Elephantiasis, Filarial / Q000188:drug therapy*; D005368:Filariasis / Q000188:drug therapy*; D007279:Injections, Subcutaneous; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*
D007559:Ivermectin