Serial analysis of fibronectin concentration in sera from septic patients.
Serum fibronectin (Fn) level was serially determined in nineteen septic patients. Fn concentration was found significantly decreased in septic patients (mean +/- SE, 120 +/- 11 micrograms/ml) as compared to the control (205 +/- 11 micrograms/ml). The decrease of Fn was correlated with the severity of sepsis; it was persistent and more important in severe septic cases. The lowest Fn concentration was found in nonsurviving patients (78 +/- 18 micrograms/ml). Serum Fn level may reflect the degree of organ failure and predict the evolution of sepsis.
Bălună
R
R
Department of Immunology, V. Babes Institute, Bucharest, Romania.
Tarnavschi
R
R
Barac
D
D
Belascu
I
I
Georgescu
H
H
D000328:Adult; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006386:Hemagglutination Tests; D006801:Humans; D018805:Sepsis / Q000097:blood*; D014591:Uterine Diseases / Q000097:blood
D005353:Fibronectins