[Analgesic activity of derivatives of 7-amino-2,3-polymethylenindoles and their congeners].
Some N-trifluoromethylsulphonyl and N-trifluoroacetylderivatives of 7-amino-2,3-polymethyleneindoles and of 7-amino-3-propylindole [(I) - (XIII)] were prepared and tested, together with corresponding aniline derivates [(XIV) - (XIX)] and with N-trifluoromethylsulphonylcyclopentylamine (XX), against formic acid induced writhings in mice. With very few exceptions, at the oral dose of 0.167 mmole/kg, they proved from 2 to 3.4 times more active than acetanilide.
Cerri
R
R
Istituto di Analitica Farmaceutica, Università di Sassari.
Boatto
G
G
Pau
A
A
Sparatore
F
F
Manca
P
P
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003517:Cyclopentanes / Q000138:chemical synthesis / Q000494:pharmacology; D005260:Female; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice
D000700:Analgesics; D000814:Aniline Compounds; D003517:Cyclopentanes; D007211:Indoles
Attività analgesica di derivati di 7-ammino-2,3-polimetilenindoli e loro congeneri.