title: [Cholestatic hepatitis caused by ketoconazole].
abstract: The authors report a new Ketoconazole-induced hepatitis in which clinical, chemical and histological features show evidence of a cholestatic injury in a 62 yrs-old female recovering once therapy is stopped. In this case-report, delay of onset of the illness is very short for a 200 mg-a-day prescription and no feature leads towards an immune response. This, may be, means that Ketoconazole-induced hepatitis should be led by an idiosyncrasic mechanism. Even if fatal hepatitis are rare, prescriptors have to beware of this therapy.
authors.affiliation: Clinique Saint-Grégoire, Tours.
authors.forename: R J
authors.initials: RJ
authors.lastname: Bensaude
authors.forename: Y
authors.initials: Y
authors.lastname: Furet
authors.forename: E
authors.initials: E
authors.lastname: Autret
authors.forename: H
authors.initials: H
authors.lastname: Brottes
authors.forename: J L
authors.initials: JL
authors.lastname: Billard
authors.forename: M
authors.initials: M
authors.lastname: Breteau
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D007654:Ketoconazole
vernacular_title: Hépatite cholestatique au kétoconazole.