title: The acute oral toxicity and primary ocular and dermal irritation of selected N-alkyl-2-pyrrolidones.
abstract: N-alkyl-2-pyrrolidones are a class of materials that are increasingly used in food, drug, cosmetic and industrial applications; however, toxicological data is only available for a few members of the class. The acute oral toxicity, primary dermal irritation and primary ocular irritation of N-methyl-, N-ethyl-, N-hydroxyethyl-, N-isopropyl-, N-cyclohexyl-, N-octyl-, N-dodecyl-, N-coco- and N-tallow-2-pyrrolidone are reported. Additionally, N-octyl-, N-decyl-, N-dodecyl-, N-tetradecyl-, N-hexadecyl- and N-octadecyl-2-pyrrolidone had the primary ocular and dermal irritation indices measured as a 2% aqueous suspension. These data show a wide range of toxicities dependent upon the alkyl substituent.
authors.affiliation: GAF Chemicals Corporation, Wayne, NJ 07470.
authors.forename: J M
authors.initials: JM
authors.lastname: Ansell
authors.forename: J A
authors.initials: JA
authors.lastname: Fowler
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005123:Eye / Q000187:drug effects* / Q000473:pathology; D007928:Lethal Dose 50; D011760:Pyrrolidinones / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects* / Q000473:pathology
chemical_list: D011760:Pyrrolidinones