title: Preliminary evaluation of praziquantel against metacercariae of Nanophyetus salmincola in chinook salmon (Oncorhynchus tshawytscha).
abstract: Praziquantel at dosages of 10, 20 or 100 mg/kg of body weight was evaluated against metacercariae of Nanophyetus salmincola in chinook salmon (Oncorhynchus tshawytscha). Ten salmon were used in each of four treated groups and 10 salmon were nontreated controls. Three wk after treatment, viability of metacercariae was determined by histologic evaluation, and by feeding the salmon to coyotes and subsequently determining the numbers of trematode eggs/g of feces and numbers of N. salmincola recovered at necropsy. Results of the experiment indicated that praziquantel at the dosages and routes of administration used was not effective against metacercariae in chinook salmon.
authors.affiliation: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.
authors.forename: W J
authors.initials: WJ
authors.lastname: Foreyt
authors.forename: J R
authors.initials: JR
authors.lastname: Gorham
mesh_terms: D000818:Animals; D002335:Carnivora / Q000469:parasitology; D005393:Fish Diseases / Q000188:drug therapy* / Q000469:parasitology; D007668:Kidney / Q000469:parasitology; D010270:Parasite Egg Count / Q000662:veterinary; D011223:Praziquantel / Q000627:therapeutic use*; D012474:Salmon / Q000469:parasitology*; D014201:Trematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*
chemical_list: D011223:Praziquantel