title: [The natural course of primary Sjögren's syndrome (a clinical study)].
abstract: In this work the authors analyzed the clinical course and diagnostic procedures of 104 patients with primary Sjogren's syndrome (pSS): 57 patients diagnosed and followed-up at Ioannina University and 47 similar patients treated at the National Institute of Health (USA). Both studies have shown that pSS is predominantly a female disease with a latent period of 6-8 yrs from the time of the first symptom to the time of final diagnosis. Although the syndrome begins almost exclusively with glandular manifestations (xerostomia, xerophthalmia or parotid gland enlargement), in a respectable percentage of patients it eventually progresses to extraglandular involvement. pSS can be potentially complicated by benign (pseudolymphoma) or malignant (lymphoma) lymphoproliferative disorders.
authors.forename: N A
authors.initials: NA
authors.lastname: Pavlidis
authors.forename: A A
authors.initials: AA
authors.lastname: Drosos
authors.forename: V
authors.initials: V
authors.lastname: Galanopoulos
authors.forename: C
authors.initials: C
authors.lastname: Siamopoulos
authors.forename: E B
authors.initials: EB
authors.lastname: Tsianos
mesh_terms: D000328:Adult; D005260:Female; D006115:Greece; D006801:Humans; D006984:Hypertrophy; D008223:Lymphoma / Q000209:etiology; D008875:Middle Aged; D010306:Parotid Gland / Q000473:pathology; D011928:Raynaud Disease / Q000175:diagnosis; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis / Q000208:ethnology*; D014481:United States; D014985:Xerophthalmia / Q000175:diagnosis / Q000208:ethnology; D014987:Xerostomia / Q000175:diagnosis / Q000208:ethnology
vernacular_title: Estestvennoe techenie pervichnogo sindroma Shegrena (klinicheskoe issledovanie).