[The role of the antithrombin III-heparin-thrombin complex in the defense reaction of the anticoagulation system].
Complexes antithrombin III-heparin-thrombin exhibiting the anticoagulation and nonenzymatic fibrinolytic activities were isolated from human blood children of 4-II years old with burns or with traumatic shock and from rat blood. The complexes antithrombin III-heparin-thrombin with high nonenzymatic fibrinolytic activity were shown to develop during activation of the anticoagulation system. In depression of the anticoagulation system these complexes, isolated from blood, demonstrated the lower nonenzymatic fibrinolytic activity, thus indicating that complex-formation is restricted.
Kudriashov
B A
BA
Liapina
L A
LA
Pastorova
V E
VE
D000818:Animals; D000990:Antithrombin III / Q000378:metabolism*; D001780:Blood Coagulation Tests; D005342:Fibrinolysis; D006493:Heparin / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D008297:Male; D051381:Rats; D013917:Thrombin / Q000378:metabolism*; D013925:Thromboplastin / Q000494:pharmacology
D000990:Antithrombin III; D006493:Heparin; D013925:Thromboplastin; D013917:Thrombin
Znachenie kompleksa antitrombin III-geparin-trombin v zashchitnoĭ reaktsii protivosvertyvaiushcheĭ sistemy.