HLA associations in heroin-associated nephropathy.
Heroin-associated nephropathy (HAN) occurs almost exclusively in black heroin abusers, suggesting a genetic link to the disease. To further study this possibility, the frequencies of HLA-A, B, C, and DR antigens were determined in a group of 47 black patients with HAN. Included in the analyses is a subgroup of 16 patients with biopsy-proven focal glomerulosclerosis. Patient frequencies were compared with three separate control populations, the first a normal black population from New York City, the second from a national registry, and the third a group of blacks with idiopathic focal glomerulosclerosis. Only the frequency of HLA-BW53 was consistently increased significantly in the patients as compared with the control groups. This finding supports the notion that a genetic predisposition may exist in the addicted population for the development of renal disease.
Haskell
L P
LP
Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467.
Glicklich
D
D
Senitzer
D
D
D000328:Adult; D001741:Black or African American; D044383:Black People; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens; D006684:HLA-DR Antigens / Q000235:genetics; D006556:Heroin Dependence / Q000150:complications* / Q000208:ethnology / Q000235:genetics; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology / Q000235:genetics; D007676:Kidney Failure, Chronic / Q000208:ethnology / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype
D006680:HLA Antigens; D015235:HLA-B Antigens; C078438:HLA-B53 antigen; D006684:HLA-DR Antigens