title: The AKT1 proto-oncogene maps to human chromosome 14, band q32.
abstract: The human AKT1 gene is the proto-oncogene of the viral oncogene v-akt. The AKT1 gene has been localized to human chromosome 14, band q32, proximal to the heavy-chain immunoglobulin locus (IGHM), by analysis of human-hamster somatic cell hybrids and by in situ hybridization. Chromosome rearrangements of this band which occur in T-lymphoid malignancies and Hodgkin's disease may affect the AKT1 gene.
authors.affiliation: Johns Hopkins Oncology Center, John Hopkins University School of Medicine, Baltimore, Maryland 21205.
authors.forename: S P
authors.initials: SP
authors.lastname: Staal
authors.forename: K
authors.initials: K
authors.lastname: Huebner
authors.forename: C M
authors.initials: CM
authors.lastname: Croce
authors.forename: N Z
authors.initials: NZ
authors.lastname: Parsa
authors.forename: J R
authors.initials: JR
authors.lastname: Testa
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D006822:Hybrid Cells / Q000166:cytology; D007621:Karyotyping; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D012190:Retroviridae / Q000235:genetics*