[Pharmacokinetics of nitrosomethylurea in oncologic patients].
Kinetics of blood-nitrosomethylurea (NMU) was studied in 68 patients with lung cancer, malignant melanoma and lymphoma who had received NMU-based combination chemotherapy. The results were used for computing main pharmacokinetic parameters such as logarithm of calculated initial concentration, time of half-elimination from blood, area under the kinetic curve of concentration, volume of distribution in the body and clearance. All those values were shown to significantly differ with individual patients. A longer retention of the drug in blood flow (as evidenced by increased time of half-elimination and area under kinetic curve matched by decreased volume of distribution and clearance) was registered in responders than in non-responders, the difference sometimes reaching statistical significance.
Korman
D B
DB
Kim
O A
OA
Gor'kov
V A
VA
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood; D008223:Lymphoma / Q000097:blood; D008297:Male; D008545:Melanoma / Q000097:blood; D008770:Methylnitrosourea / Q000097:blood / Q000493:pharmacokinetics*; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*
D008770:Methylnitrosourea
Farmakokinetika nitrozometilmocheviny u onkologicheskikh bol'nykh.