Effect of acetylhomocysteine thiolactone on nucleolar cytology and lipofuscinogenesis in electric lobe neurons.
Treatment with acetylhomocysteine thiolactone significantly reduces the cellular level of lipofuscin in neurons of the electric lobe of Torpedo marmorata. At the same time, this drug produces a 45% decrease in nucleolar volume in these neurons, reflecting decreased cellular synthetic activity.
Enesco
H E
HE
Department of Biology, Concordia University, Montreal, Quebec, Canada.
Enesco
M A
MA
Aloj Totaro
E
E
Pisanti
F A
FA
D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects* / Q000648:ultrastructure; D004557:Electric Organ / Q000187:drug effects / Q000648:ultrastructure; D008062:Lipofuscin / Q000378:metabolism*; D010860:Pigments, Biological / Q000378:metabolism*; D013876:Thiophenes / Q000494:pharmacology*; D014101:Torpedo
D008062:Lipofuscin; D010860:Pigments, Biological; D013876:Thiophenes; C000486:citiolone