A83586C, a new depsipeptide antibiotic.
A culture identified as Streptomyces karnatakensis was found to produce a novel cyclic hexadepsipeptide antibiotic designated A83586C. The structure was elucidated by X-ray crystallography, and full 1H and 13C NMR assignments are reported. The absolute configuration was confirmed by the detection of D-threonine in the acid hydrolysate of A83586C. A83586C had potent Gram-positive activity in vitro but lacked in vivo efficacy in mice.
Smitka
T A
TA
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
Deeter
J B
JB
Hunt
A H
AH
Mertz
F P
FP
Ellis
R M
RM
Boeck
L D
LD
Yao
R C
RC
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D047630:Depsipeptides; D005285:Fermentation; D051379:Mice; D008968:Molecular Conformation; D010455:Peptides; D010456:Peptides, Cyclic / Q000302:isolation & purification; D013302:Streptomyces / Q000145:classification / Q000378:metabolism
D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D010455:Peptides; D010456:Peptides, Cyclic; C056791:A 83586C