title: Effect of intestinal ischemia on pulmonary surfactant. An experimental study.
abstract: The infective factor seems to be very important in the physiopathology of intestinal ischaemia syndrome, as we suggested in previous research works, and is probably responsible for the disturbances observed in pulmonary surfactant. In the present research project, 48 mongrel dogs were studied under different situations of experimental intestinal ischaemia (arterial, venous and revascularization) after laparotomy and the pulmonary surfactant was determined in all cases. We conclude that the observed changes in phospholipids (phosphatidylglycerol and phosphatidylinositol particularly) can be directly related to the infective factor and important enough to induce physicochemical alterations of the surfactant and subsequently pulmonary function.
authors.affiliation: Departamento de Cirugía, Facultad de Medicina, Universidad de Salamanca, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Gómez Alonso
authors.forename: F
authors.initials: F
authors.lastname: Cuadrado Idoyaga
authors.forename: J L
authors.initials: JL
authors.lastname: Villar Galan
authors.forename: A
authors.initials: A
authors.lastname: Pérez Garcia
authors.forename: M
authors.initials: M
authors.lastname: Rodriguez Morán
authors.forename: M
authors.initials: M
authors.lastname: Milicua
authors.forename: J A
authors.initials: JA
authors.lastname: Cabezas
authors.forename: M N
authors.initials: MN
authors.lastname: Pérez Gonzalez
mesh_terms: D000818:Animals; D004285:Dogs; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000503:physiopathology*; D008641:Mesenteric Vascular Occlusion / Q000503:physiopathology; D010715:Phosphatidylglycerols / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D011663:Pulmonary Surfactants / Q000378:metabolism*; D013997:Time Factors
chemical_list: D010715:Phosphatidylglycerols; D010716:Phosphatidylinositols; D011663:Pulmonary Surfactants