Spontaneous regression of a small non-cleaved cell malignant lymphoma (non-Burkitt's lymphoblastic lymphoma). Morphologic, immunohistological, and immunoglobulin gene analysis.
Complete spontaneous regression of high-grade malignant non-Hodgkin's lymphoma is extremely unusual. In this report the authors describe a complete spontaneous remission after surgical excisional biopsy of a small noncleaved cell malignant lymphoma (non-Burkitt's lymphoblastic lymphoma) of the tonsil in a 12-year-old boy. The diagnosis was confirmed by immunohistologic and immunoglobulin gene analysis. Similar studies were performed on the cervical lymph node excised 2 weeks later when spontaneous remission had occurred. The patient has remained in good health for over 3 years.
Poppema
S
S
Department of Pathology, University of Groningen, The Netherlands.
Postma
L
L
Brinker
M
M
de Jong
B
B
D000293:Adolescent; D000951:Antigens, Neoplasm / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000473:pathology*; D008297:Male; D009365:Neoplasm Regression, Spontaneous; D009693:Nucleic Acid Hybridization; D014067:Tonsillar Neoplasms / Q000276:immunology / Q000473:pathology*
D000951:Antigens, Neoplasm; D007136:Immunoglobulins