Estimation of a common odds ratio in case-control studies of familial aggregation.
A new estimator of a common odds ratio is proposed for case-control studies of familial aggregation. The proposed estimator is a modification to the usual Mantel-Haenszel estimator that relies on an empirical adjustment for the within-family clustering which is typical of such designs. A simulation study shows that the estimator tends to have smaller mean squared error than the unmodified Mantel-Haenszel estimator under conditions likely to arise in practice. The construction of confidence intervals is also discussed.
Donner
A
A
Department of Epidemiology and Biostatistics, University of Western Ontario, London, Canada.
Hauck
W
W
D001699:Biometry / Q000379:methods*; D004812:Epidemiologic Methods; D030342:Genetic Diseases, Inborn / Q000453:epidemiology*; D006801:Humans