Cytotoxic effects of recombinant human biological response modifiers on head and neck carcinoma cells.
The present report shows that the simultaneous application of two biological response modifiers (recombinant human gamma-interferon plus recombinant human alpha-tumor necrosis factor) has a lethal effect on living laryngeal and salivary gland carcinomas. A cytostatic or cytotoxic effect of the two substances alone could only be observed in occasional cases. The results suggest a synergistic action of gamma-interferon and alpha-tumor necrosis factor that might be of therapeutic value for head and neck carcinomas in the future.
Zenner
H P
HP
Department of Otolaryngology, University of Würzburg, FRG.
Zimmermann
U
U
D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002460:Cell Line; D002470:Cell Survival; D004357:Drug Synergism; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007822:Laryngeal Neoplasms / Q000473:pathology*; D011994:Recombinant Proteins / Q000494:pharmacology; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D007370:Interferon Type I; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha