[Localized neutrophilic eccrine hydradenitis in mitoxantrone therapy: a typical side-effect of cytostatic drugs].
In a 59 year-old woman, polychemotherapy with cyclophosphamide and mitoxantrone was started because of liver and bone marrow metastases following operative treatment of breast cancer with subsequent X-ray treatment in 1982. Three weeks after the fourth cycle of polychemotherapy multiple small, firm, reddish papules and pustules developed on the lymphedematous right arm. Histology revealed a dense, well-circumscribed granulocytic infiltrate around the acrosyringial part of the sweat gland duct. Skin lesions cleared completely after the chemotherapy had been changed to cyclophosphamide, methotrexate, and 5-FU. The purpose of our report is to present this largely unknown distinct clinicopathologic entity caused by anthracyclines.
Burg
G
G
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, München.
Bieber
T
T
Langecker
P
P
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D003131:Combined Modality Therapy; D004439:Eccrine Glands / Q000187:drug effects*; D005260:Female; D006801:Humans; D007249:Inflammation; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage / Q000009:adverse effects*; D009504:Neutrophils / Q000187:drug effects; D013543:Sweat Gland Diseases / Q000139:chemically induced*; D013545:Sweat Glands / Q000187:drug effects*
D008942:Mitoxantrone
Lokalisierte neutrophile ekkrine Hidradenitis unter Mitoxantron: eine typische Zytostatikanebenwirkung.