title: GI transit and absorption of solid food: multiple effects of guar.
abstract: These experiments were undertaken in dogs with midintestinal fistulas to determine whether guar added to a meal of solid food would disrupt gastric sieving and give rise to maldigestion of solid food. Dogs were fed a standard meal of steak, chicken liver, bread, margarine, and water in which there was 0, 3.3, 7.5, or 15 g guar powder. The margarine or the liver contained [14C]triolein. Using an isotope ratio method, we determined how much [14C]triolein was absorbed at midintestine. We found that guar in a dose-related fashion increased the weight of chyme collected at midintestine, markedly reduced the percent of triolein absorbed by midintestine from 88 to 38%, and profoundly increased the passage to midintestine of large, poorly digestible pieces of steak and liver. The viscosity of the guar promoted the GI transit of large, poorly digestible pieces of food but also reduced absorption by other mechanisms.
authors.affiliation: Department of Medicine, Sepulveda VA Hospital, CA.
authors.forename: J H
authors.initials: JH
authors.lastname: Meyer
authors.forename: J E
authors.initials: JE
authors.lastname: Doty
mesh_terms: D000818:Animals; D002913:Chyle / Q000032:analysis; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005502:Food; D005685:Galactans / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007408:Intestinal Absorption / Q000187:drug effects*; D008351:Mannans / Q000494:pharmacology*; D008383:Margarine; D053149:Plant Gums; D014304:Triolein / Q000493:pharmacokinetics; D014783:Viscosity
chemical_list: D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D014304:Triolein; D008383:Margarine; C007894:guar gum