Development of dopamine-containing neurons and dopamine uptake in embryos of Hirudo medicinalis.
The embryonic development of neurons which contain or take up dopamine was studied with glyoxylic acid histofluorescence in Hirudo medicinalis. Beginning at the time of the formation of the tail ganglion, one pair of dopamine-containing neurons was stained per segmental ganglion. The normal outgrowth of the cell bodies into the anterior roots was prevented in isolated and cultured chains of embryonic ganglia. Preincubation of intact embryos in dopamine led to the staining of additional neurons at certain developmental stages. These neurons presumably are the precursors of serotonin-containing cells, which have a temporary capability of taking up and storing dopamine.
Dietzel
I D
ID
Department of Neurophysiology, Max Planck Institute for Psychiatry, Planegg-Martinsried, Federal Republic of Germany.
Gottmann
K
K
D000818:Animals; D004298:Dopamine / Q000032:analysis / Q000493:pharmacokinetics*; D007865:Leeches / Q000196:embryology*; D009474:Neurons / Q000032:analysis*; D012016:Reference Values
D004298:Dopamine