title: Synthesis of p-menthane derivatives with potential biological activity.
abstract: The synthesis of amino ketones and amino alcohols in p-menthane series is presented. These compounds were obtained in Mannich reaction, starting from the unsaturated ketone p-mentha-6,8-dien-2-one and its saturated analogue p-menthan-2-one. The structures of the compounds obtained were established by means of chemical transformations and elemental and spectral (IR, 1H NMR) analysis. The compounds obtained were subjected to the pharmacological investigations.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy Medical Academy, Wrocław, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Witkiewicz
authors.forename: Z
authors.initials: Z
authors.lastname: Rykowski
authors.forename: Z
authors.initials: Z
authors.lastname: Machoń
authors.forename: U
authors.initials: U
authors.lastname: Lipnicka
authors.forename: K
authors.initials: K
authors.lastname: Burak
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007659:Ketones / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D013729:Terpenes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000605:Amino Alcohols; D002491:Central Nervous System Agents; D007659:Ketones; D013729:Terpenes