[Protein kinase A and C activity of erythrocytes in patients with essential hypertension].
Activities of protein kinases A and C in erythrocyte cytoplasmic fraction purified by CM-Sephadex and DEAE-cellulose have been measured. Protein kinase C activity is shown to be 1.6-1.8-fold higher, as compared to controls, in essential hypertension, but remain unchanged in renal hypertension. Protein kinase A activity is slightly elevated in patients with essential hypertension, but the difference is not significant. It is suggested that the increase of protein kinase C activity, and perhaps some other activities as well, in essential hypertension may be a result of altered expression of protooncogenes with protein kinase activities.
Kravtsov
G M
GM
Dulin
N O
NO
Postnov
Iu V
IuV
D000328:Adult; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D011493:Protein Kinase C / Q000097:blood; D011494:Protein Kinases / Q000097:blood*
D011494:Protein Kinases; D011493:Protein Kinase C
Aktivnost' proteinkinaz A i C v éritrotsitakh bol'nykh s éssentsial'noĭ gipertenzieĭ.