Choleretic actions of iridoid compounds.
The intravenous administration of 50 and 100 mg/kg of genipin (GP), gardenogenins (GAR-G), deacetylasperulosidic acid methylester genins (DAM-G), and scandoside methylester genin (SSM-G) exhibited the bile acid-independent choleretic actions. The action of DAM-G was stronger than the actions of other compounds tested. The choleretic action of SSM-G was milder, but longer lasting than those of GAR-G and DAM-G.
Miyagoshi
M
M
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Amagaya
S
S
Ogihara
Y
Y
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D002756:Cholagogues and Choleretics; D004573:Electrolytes / Q000378:metabolism; D005960:Glucosides / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D039823:Iridoids; D008297:Male; D011714:Pyrans / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D004573:Electrolytes; D005960:Glucosides; D006027:Glycosides; D039823:Iridoids; D011714:Pyrans; C007835:geniposide; C056587:gardenoside