Effect of adenosine and pertussis vaccine on lymphocyte response in vitro to phytohemagglutinin in asthmatic and non-asthmatic subjects.
Adenosine and pertussis vaccine each significantly suppressed the in vitro lymphocyte response to phytohemagglutinin (PHA) in both asthmatic and non-asthmatic subjects. On the other hand, pertussis vaccine significantly enhanced the response of the lymphocytes treated with a lower concentration of adenosine both in asthmatic and non-asthmatic subjects. It was also shown that lymphocytes from asthmatic and non-asthmatic subjects responded similarly to the modulating effect of adenosine and/or pertussis vaccine on PHA stimulation. These data give further evidence for the complex interplay of the vaccine with endogenous adenosine.
Hiratani
M
M
McCall
M K
MK
Chaperon
E A
EA
Townley
R G
RG
D000241:Adenosine / Q000494:pharmacology*; D000328:Adult; D001249:Asthma / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007108:Immune Tolerance; D008213:Lymphocyte Activation / Q000187:drug effects*; D010567:Pertussis Vaccine / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology
D010567:Pertussis Vaccine; D010835:Phytohemagglutinins; D000241:Adenosine