title: Phenotype of mononuclear leucocytes resident in rat major salivary and lacrimal glands.
abstract: The phenotypic distribution of lymphocytes and mononuclear phagocytes resident in rat secretory glands was examined. Isolated exocrine gland mononuclear leucocyte populations contained 50-61% W3/13+ T cells and greater proportions of W3/25+ T helper cells relative to OX8+ T suppressor cells. Surface Ig+ cells (sIg) constituted from 32% to 34% of the cells and their distribution was sIgM greater than sIgA greater than sIgG. The macrophage populations comprised from 0.02% to 0.1% of the unfractionated gland cells. Fractionated secretory gland-adherent cells consisted primarily of non-specific esterase+, phagocytic and Fc receptor-bearing cells. From 35% to 79% of the macrophages in exocrine glands expressed I-A molecules. The results suggest that exocrine glands have the ability to respond locally to an antigenic challenge independently of a central mucosal immune response.
authors.affiliation: Department of Immunology, Forsyth Dental Center, Boston, Massachusetts.
authors.forename: J
authors.initials: J
authors.lastname: Pappo
authors.forename: J L
authors.initials: JL
authors.lastname: Ebersole
authors.forename: M A
authors.initials: MA
authors.lastname: Taubman
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D002448:Cell Adhesion; D002499:Centrifugation, Density Gradient; D007765:Lacrimal Apparatus / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000145:classification*; D010587:Phagocytosis; D051381:Rats; D011916:Rats, Inbred F344; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012469:Salivary Glands / Q000276:immunology*
chemical_list: D000954:Antigens, Surface; D011947:Receptors, Antigen, B-Cell