title: Oral inflammatory changes as an initial manifestation of Crohn's disease antedating abdominal diagnosis. Report of a case.
abstract: The case of a 14-year-old boy who had oral ulcers with histologic proof of granulomatous disease nine months before the diagnosis of intestinal Crohn's disease is presented. Additional extraintestinal manifestations of this case were cheilitis, anal fissures, and "metastatic" disease to the umbilicus. The diagnosis was established after the onset of abdominal symptoms. All manifestations responded rapidly to systemic prednisone, sulfasalazine, and metronidazole.
authors.affiliation: Department of Medicine, St. Josef-Hospital, Ruhr-University, Bochum, Federal Republic of Germany.
authors.forename: C
authors.initials: C
authors.lastname: Coenen
authors.forename: G
authors.initials: G
authors.lastname: Börsch
authors.forename: K M
authors.initials: KM
authors.lastname: Müller
authors.forename: H
authors.initials: H
authors.lastname: Fabry
mesh_terms: D000293:Adolescent; D001003:Anal Canal / Q000473:pathology; D002613:Cheilitis / Q000150:complications / Q000473:pathology; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007801:Langerhans Cells / Q000473:pathology; D008297:Male; D012871:Skin Diseases / Q000150:complications / Q000473:pathology; D013281:Stomatitis, Aphthous / Q000150:complications* / Q000473:pathology; D014472:Umbilicus