Repetitive spikes in cytoplasmic calcium evoked by histamine in human endothelial cells.
Measurement of cytoplasmic free calcium, [Ca2+]i, in single human endothelial cells has shown that low doses of the inflammatory mediator histamine evoke asynchronous repetitive spikes in [Ca2+]i whereas high doses cause a maintained elevated [Ca2+]i. We discuss possible regulatory mechanisms, and the potential physiological and pathological implications of such a frequency-modulated [Ca2+]i signalling system.
Jacob
R
R
Smith Kline & French Research Limited, The Frythe, Welwyn, Hertfordshire, UK.
Merritt
J E
JE
Hallam
T J
TJ
Rink
T J
TJ
D002118:Calcium / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004727:Endothelium / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D011188:Potassium / Q000378:metabolism
D006632:Histamine; D011188:Potassium; D002118:Calcium