Multiple sclerosis autoantibodies and antibodies in AIDS may deplete a brain peptide hormone.
Computerized Chou-Fasman analysis of the secondary structure of human T-cell leukemia viruses (HTLV-I, HTLV-II) and human immunodeficiency virus (HIV) envelope proteins revealed that only one antigenic epitope (amino acids EAL) is shared by the three viruses. A similar antigenic epitope is also found in human and rat brain hormone vasopressin-neurophysin. If autoantibodies in multiple sclerosis (MS) are made to the epitope EAL, they may cross-react with the envelope proteins of HTVL. It is speculated that in AIDS patients, antibodies to the antigenic epitope EAL of HIV may cross-react with brain vasopressin-neurophysin, leading to a decline in this brain peptide hormone. Thus it is hypothesized that treatment of both MS and AIDS patients with a synthetic polymer containing the amino acids EAL might eliminate the antibodies to vasopressin-neurophysin and thus alleviate some of the clinical symptoms.
Becker
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Department of Molecular Virology, Faculty of Medicine, Hebrew University, Jerusalem, Isreal.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D003429:Cross Reactions; D006678:HIV / Q000032:analysis; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology*; D009479:Neuropeptides / Q000032:analysis*; D009481:Neurophysins / Q000032:analysis; D014667:Vasopressins / Q000032:analysis; D014759:Viral Envelope Proteins / Q000032:analysis
D000914:Antibodies, Viral; D001323:Autoantibodies; D009479:Neuropeptides; D009481:Neurophysins; D014759:Viral Envelope Proteins; D014667:Vasopressins