Apomorphine-induced hypothermia increases during ethanol withdrawal.
Changes in several measures of dopamine function have been observed following acute or chronic ethanol exposure. The present study examined the effects of chronic ethanol exposure on the hypothermia following acute administration of the dopamine agonist apomorphine. Animals withdrawn from chronic ethanol exposure showed a significantly greater decrease in body temperature following apomorphine than did ethanol-naive controls, suggesting an increase in sensitivity to dopaminergic stimulation during ethanol withdrawal.
Gonzalez
L P
LP
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
Colbern
D L
DL
Czachura
J F
JF
D000437:Alcoholism / Q000097:blood / Q000503:physiopathology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000503:physiopathology*
D001058:Apomorphine