title: Use of halothane to maintain anesthesia induced with etorphine in juvenile African elephants.
abstract: Sixteen 3- to 5-year-old African elephants were anesthetized one or more times for a total of 27 diagnostic and surgical procedures. Xylazine (0.1 +/- 0.04 mg/kg of body weight, mean +/- SD) and ketamine (0.6 +/- 0.13 mg/kg) administered IM induced good chemical restraint in standing juvenile elephants during a 45-minute transport period before administration of general anesthesia. After IM or IV administration of etorphine (1.9 +/- 0.56 micrograms/kg), the mean time to lateral recumbency was 20 +/- 6.6 and 3 +/- 0.0 minutes, respectively. The mean heart rate, systolic blood pressure, and respiration rate during all procedures was 50 +/- 12 beats/min, 106 +/- 19 mm of Hg, and 10 +/- 3 breaths/min, respectively. Cardiac arrhythmias were detected during 2 procedures. One elephant with hypotension responded to a decrease in the concentration of halothane and IV infusion of dobutamine HCl. Alterations in systolic blood pressure, ear flapping, and trunk muscle tone were useful for monitoring depth of anesthesia. Results indicated that halothane in oxygen was effective for maintenance of surgical anesthesia in juvenile African elephants after induction with etorphine.
authors.affiliation: Department of Special Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
authors.forename: D J
authors.initials: DJ
authors.lastname: Heard
authors.forename: G V
authors.initials: GV
authors.lastname: Kollias
authors.forename: A I
authors.initials: AI
authors.lastname: Webb
authors.forename: E R
authors.initials: ER
authors.lastname: Jacobson
authors.forename: K A
authors.initials: KA
authors.lastname: Brock
mesh_terms: D000758:Anesthesia / Q000662:veterinary*; D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004606:Elephants; D005048:Etorphine / Q000494:pharmacology; D005260:Female; D006221:Halothane / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009019:Morphinans / Q000494:pharmacology
chemical_list: D000777:Anesthetics; D009019:Morphinans; D005048:Etorphine; D006221:Halothane