[Characteristics of the biochemical manifestation of the process of thymic lymphocyte death following UV irradiation].
Thymus lymphocyte death caused by UV-radiation is a function of radiation dose. Thymocyte death induced by UV-light, in contrast to gamma-radiation, is not accompanied by chromatin degradation. With UV-irradiation, irreparable DNA breaks are not responsible for thymocyte death. Cycloheximide, but not cysteamine, prevents the UV-induced cell death.
Soldatenkov
V A
VA
Trebenok
Z A
ZA
Filippovich
I V
IV
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002843:Chromatin / Q000187:drug effects / Q000528:radiation effects; D003513:Cycloheximide / Q000494:pharmacology; D004247:DNA / Q000187:drug effects / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D013997:Time Factors; D014466:Ultraviolet Rays
D002843:Chromatin; D004247:DNA; D003513:Cycloheximide
Osobennosti biokhimicheskogo proiavleniia protsessa gibeli limfotsitov timusa posle UF-oblucheniia.