title: Intolerance to tartrazine in aspirin-induced asthma: results of a multicenter study.
abstract: One hundred and fifty-six German, Italian and Polish patients with confirmed aspirin-induced asthma underwent open oral challenges with increasing doses of tartrazine up to 25 mg. All positive challenges were repeated under double-blind conditions. Only 4 of 156 patients (all Polish) had positive reactions in a double-blind test, as evidenced by a fall in FEV1 greater than 25% from baseline and corresponding clinical symptoms. Sixty-five patients who tolerated 25 mg tartrazine well received 50-3,000 mg tartrazine and none showed adverse reactions. Thus, intolerance to tartrazine appears to be rare among Central-European and South-European patients with aspirin-induced asthma, its frequency amounting to about 2.6%.
authors.affiliation: Hochgebirgsklinik Davos-Wolfgang, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Virchow
authors.forename: A
authors.initials: A
authors.lastname: Szczeklik
authors.forename: S
authors.initials: S
authors.lastname: Bianco
authors.forename: M
authors.initials: M
authors.lastname: Schmitz-Schumann
authors.forename: E
authors.initials: E
authors.lastname: Juhl
authors.forename: M
authors.initials: M
authors.lastname: Robuschi
authors.forename: C
authors.initials: C
authors.lastname: Damonte
authors.forename: G
authors.initials: G
authors.lastname: Menz
authors.forename: M
authors.initials: M
authors.lastname: Serwonska
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced*; D001391:Azo Compounds / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004342:Drug Hypersensitivity / Q000209:etiology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013645:Tartrazine / Q000009:adverse effects*
chemical_list: D001391:Azo Compounds; D013645:Tartrazine; D001241:Aspirin