title: Studies on coagulation, fibrinolysis, kallikrein-kinin and complement activation in systemic and pulmonary circulation during hip arthroplasty with acrylic cement.
abstract: This study was designed to evaluate the contribution of the plasma cascade systems to the cardiopulmonary complications, occasionally leading to sudden death during hip arthroplasty using acrylic cement. The intraoperative pattern following uneventful surgery was therefore investigated in 8 patients with osteoarthrosis with frequent sampling from the radial and pulmonary arteries. The following general findings emerged: A gradual consumption of coagulation factors (platelets, fibrinogen, factor VII, antithrombin III), fibrinolytic components (plasminogen, alpha-2-antiplasmin), kallikrein-kinin factors (prekallikrein, kallikrein inhibitor) and complement factors (C3c, C4) was observed. Some intrapulmonary proteolytic inhibition was noticed as evidenced by lower arterial than mixed venous blood levels of alpha-2-antiplasmin and kallikrein inhibitor. Insignificant changes occurred for factor VII-phospholipid complex. A rapid, massive and transient increase in fibrinopeptide A (FPA) values in the radial artery, as opposed to the moderate increase in the pulmonary artery, was found immediately after reaming and broaching of bone. This probably reflected intrapulmonary fibrinogen to fibrin conversion, reaching a maximum 15-20 minutes before the femoral implantation. As estimated from the FPA arterial peak values and the fall in fibrinogen concentrations, approximately 5-10% of the circulating fibrinogen molecules were devoided of FPA during this intraoperative phase. The marked a-v difference in FPA level supports earlier findings of intrapulmonary fibrin formation and deposition. This process, however preceded the critical period of cardiorespiratory collapse (CRC) by at least 15 minutes, and may thus predispose to this complication.
authors.affiliation: Department of Surgery, Diakonhjemmets sykehus (The Norwegian Lutheran Hospital), Oslo.
authors.forename: O E
authors.initials: OE
authors.lastname: Dahl
authors.forename: I
authors.initials: I
authors.lastname: Molnar
authors.forename: A
authors.initials: A
authors.lastname: Vinje
authors.forename: J S
authors.initials: JS
authors.lastname: Rø
authors.forename: P
authors.initials: P
authors.lastname: Kierulf
authors.forename: A B
authors.initials: AB
authors.lastname: Andersen
authors.forename: K
authors.initials: K
authors.lastname: Dalaker
authors.forename: H
authors.initials: H
authors.lastname: Prydz
mesh_terms: D000179:Acrylates; D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation; D003167:Complement Activation; D005260:Female; D005342:Fibrinolysis; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007431:Intraoperative Complications; D007610:Kallikreins / Q000097:blood; D007705:Kinins / Q000097:blood; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation / Q000187:drug effects*
chemical_list: D000179:Acrylates; D007705:Kinins; D007610:Kallikreins