Transnitrosating activity of N-nitroso-N-methyl-p-toluenesulfonamide in rats and human gastric juice.
N-nitroso-N-methyl-p-toluenesulfonamide (NMTS, diazald, CAS 80-11-5) is a widely used compound for laboratory production of diazomethane. The present results showed that the noncarcinogenic NMTS reacts as a transnitrosating agent with amino nitrogen of secondary amines and amide both in vitro (human gastric juice) and in vivo (rats) to yield N-nitroso compounds. Since all compounds formed (NMOR, NDMA, NPIP, NPZ, NMU) are known animal carcinogens, caution should be taken by users handling NMTS.
Börzsönyi
M
M
National Institute of Hygiene, Budapest, Hungary.
Sajgó
K
K
Török
G
G
Pintér
A
A
Tamás
J
J
Kolar
G
G
Spiegelhalder
B
B
D000577:Amides / Q000378:metabolism; D000588:Amines / Q000378:metabolism; D000818:Animals; D002273:Carcinogens; D004781:Environmental Exposure; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D009602:Nitrosamines / Q000096:biosynthesis / Q000633:toxicity*; D009603:Nitroso Compounds / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D014105:Tosyl Compounds
D000577:Amides; D000588:Amines; D002273:Carcinogens; D009602:Nitrosamines; D009603:Nitroso Compounds; D014105:Tosyl Compounds; C002741:N-nitrosomorpholine; C056772:diazalo