Venous drainage of the femur permits passage of 100-micron particles.
Iatrogenic metastasis of bone tumor is reportedly increased if aggregates of tumor cells enter the circulation. The current study used a previously developed animal model to explore the movement of 25-, 50-, and 100-micron-diameter particles from an experimental femur biopsy site into the circulation. The results indicate that cell aggregate-sized particles can enter the circulation from the femur at a rate similar to that of the 15-micron particles used in previous studies. Arterial blood samples collected during and after the injection of particles contained no 50- or 100-micron particles, suggesting that the lung is an effective filter for these larger particles.
Janssen
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Department of Orthopaedic Surgery, Texas Tech University Health Sciences Center, Lubbock 79430.
Robertson
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Berlin
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D000818:Animals; D001859:Bone Neoplasms / Q000473:pathology; D004285:Dogs; D005260:Female; D005263:Femoral Artery; D005268:Femoral Vein; D005269:Femur / Q000098:blood supply*; D008168:Lung / Q000473:pathology; D008297:Male; D008863:Microspheres; D008954:Models, Biological; D009360:Neoplastic Cells, Circulating; D010316:Particle Size; D011137:Polystyrenes
D011137:Polystyrenes