Investigation of dressings designed for treatment of alveolitis sicca dolorosa. Part 4: Analysis of the mechanism of liberation of drugs from dressings in vivo.
Analysis of liberation of medical substances from dressing for treatment of dry tooth-socket proved that this process proceeds simultaneously to two receiving compartments. Liberation to saliva proceeds as in vitro conditions, whereas liberation to tissue of the tooth-socket is limited by the absorption rate. Based on measurements carried out in vitro one can predict the period of effectiveness of the dressings in vivo. It is evident that results of measurements in vitro can be correlated with those in vivo.
Kubis
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Department of Pharmaceutical Technology, Medical Academy, Wrocław, Poland.
D001458:Bandages; D004058:Diffusion; D004368:Dry Socket / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010599:Pharmacokinetics; D012463:Saliva / Q000378:metabolism
D004364:Pharmaceutical Preparations