Hypogonadotrophic variant of Klinefelter's syndrome. A case report.
A 16-year-old boy with 47,XXY chromosomal complement (Klinefelter's syndrome) presented with delayed puberty and apparent gonadotrophin deficiency. Despite an inadequate growth hormone response to insulin-induced hypoglycaemia and to L-dopa administration, his somatic growth was appropriate for his delay in pubertal development, increasing markedly on testosterone treatment. Patients with Klinefelter's syndrome may have abnormalities of neuro-endocrine regulation.
Wittenberg
D F
DF
Department of Paediatrics and Child Health, University of Natal, Durban.
Padayachi
T
T
Norman
R J
RJ
D000293:Adolescent; D006065:Gonadotropins, Pituitary / Q000172:deficiency*; D006801:Humans; D007713:Klinefelter Syndrome / Q000503:physiopathology*; D008297:Male; D010901:Pituitary Function Tests; D011628:Puberty, Delayed
D006065:Gonadotropins, Pituitary