Magnesium plus nifedipine: potentiation of hypotensive effect in preeclampsia?
Two women with preeclampsia treated unsuccessfully with alpha-methyldopa and magnesium sulfate became profoundly hypotensive when oral nifedipine was added. Blood pressure returned to previous levels without changes in fetal vitality. Awareness of this potentiation is important because nifedipine is being used increasingly in the treatment of pregnancy-related hypertension.
Waisman
G D
GD
Department of Medicine, Hospital Italiano de Buenos Aires, Capital Federal, Argentina.
Mayorga
L M
LM
Cámera
M I
MI
Vignolo
C A
CA
Martinotti
A
A
D000328:Adult; D004357:Drug Synergism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D008750:Methyldopa / Q000627:therapeutic use*; D009543:Nifedipine / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy
D008750:Methyldopa; D008278:Magnesium Sulfate; D009543:Nifedipine