title: Isolation of a new phenazine antibiotic, DOB-41, from Pseudomonas species.
abstract: A new phenazine antibiotic, DOB-41, was isolated from the culture broth of a Pseudomonas strain. The antibiotic obtained as yellow crystals showed UV maxima at 255 nm and 370 nm. A molecular formula, C19H18N2O6, was indicated by elemental analysis and mass spectrometry. The structure was elucidated by X-ray diffraction analysis. The antibiotic exhibited inhibitory activity against Gram-positive bacteria, and antitumor effect against leukemia P388 in mice.
authors.affiliation: Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Shoji
authors.forename: R
authors.initials: R
authors.lastname: Sakazaki
authors.forename: H
authors.initials: H
authors.lastname: Nakai
authors.forename: Y
authors.initials: Y
authors.lastname: Terui
authors.forename: T
authors.initials: T
authors.lastname: Hattori
authors.forename: O
authors.initials: O
authors.lastname: Shiratori
authors.forename: E
authors.initials: E
authors.lastname: Kondo
authors.forename: T
authors.initials: T
authors.lastname: Konishi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D010619:Phenazines / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D011549:Pseudomonas / Q000032:analysis / Q000145:classification; D013057:Spectrum Analysis; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D010619:Phenazines; C056339:DOB-41 antibiotic