title: [Value of cyclosporin A in dermatomyositis in a child].
abstract: Cyclosporin A was used in a 3 1/2 year-old child with dermatomyositis exhibiting severe junctional impairment and intolerance to steroids. After a few weeks, marked clinical improvement was observed allowing a reduction of the doses of steroids. After 9 months, the clinical status was satisfactory: the calcifications had lost their inflammatory characteristics. No side effect of cyclosporin A was observed at the dose used (4.4 mg/kg/d) which maintained effective blood concentrations between 80 and 220 ng/ml.
authors.affiliation: Service de Pédiatrie, Laboratoire Hospitalo-Universitaire de Pharmacologie, Centre Hospitalier Intercommunal, Créteil.
authors.forename: P
authors.initials: P
authors.lastname: Reinert
authors.forename: C
authors.initials: C
authors.lastname: Hamberger
authors.forename: M C
authors.initials: MC
authors.lastname: Rahimy
authors.forename: C
authors.initials: C
authors.lastname: Dusseau
authors.forename: F
authors.initials: F
authors.lastname: Bernaudin
authors.forename: J
authors.initials: J
authors.lastname: Barre
authors.forename: J P
authors.initials: JP
authors.lastname: Tillement
authors.forename: S
authors.initials: S
authors.lastname: Lemerle
mesh_terms: D002675:Child, Preschool; D003524:Cyclosporins / Q000627:therapeutic use*; D003882:Dermatomyositis / Q000188:drug therapy*; D004351:Drug Resistance; D005260:Female; D006801:Humans
chemical_list: D003524:Cyclosporins
vernacular_title: Intérêt de la cyclosporine A dans la dermatomyosite de l'enfant.