title: A83586C, a new depsipeptide antibiotic.
abstract: A culture identified as Streptomyces karnatakensis was found to produce a novel cyclic hexadepsipeptide antibiotic designated A83586C. The structure was elucidated by X-ray crystallography, and full 1H and 13C NMR assignments are reported. The absolute configuration was confirmed by the detection of D-threonine in the acid hydrolysate of A83586C. A83586C had potent Gram-positive activity in vitro but lacked in vivo efficacy in mice.
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
authors.forename: T A
authors.initials: TA
authors.lastname: Smitka
authors.forename: J B
authors.initials: JB
authors.lastname: Deeter
authors.forename: A H
authors.initials: AH
authors.lastname: Hunt
authors.forename: F P
authors.initials: FP
authors.lastname: Mertz
authors.forename: R M
authors.initials: RM
authors.lastname: Ellis
authors.forename: L D
authors.initials: LD
authors.lastname: Boeck
authors.forename: R C
authors.initials: RC
authors.lastname: Yao
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D047630:Depsipeptides; D005285:Fermentation; D051379:Mice; D008968:Molecular Conformation; D010455:Peptides; D010456:Peptides, Cyclic / Q000302:isolation & purification; D013302:Streptomyces / Q000145:classification / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D010455:Peptides; D010456:Peptides, Cyclic; C056791:A 83586C