title: Quantitation of myocardial dyssynergy in closed-chest dogs by two-dimensional echocardiography.
abstract: Myocardial infarction was produced in 29 anaesthetized mongrel dogs by a closed-chest coronary occlusion technique. A two-dimensional echocardiographic examination (2-D echo) was carried out just before occlusion and again 48 h after occlusion. Many cross-sectional images were recorded by a video-tape recorder. The applied site of the probe was fixed in an intercostal space and the direction of the ultrasonic beam was tilted stepwise from the basis to the apex. The animals were sacrificed at 49 hours after occlusion. The hearts were removed, quick frozen, sliced into radiating sections and stained with nitroblue tetrazolium (NBT). The outline of dyssynergy, including dyskinesis, akinesis or extreme hypokinesis, was traced with a tablet digitizer by two specialists. The three-dimensional image of dyssynergy in the left ventricular wall was reconstructed by a computer in spherical co-ordinates and assumed to be made of numerous triangular pyramids. The volume of dyssynergy was calculated quantitatively as the sum of volumes of these numerous triangular pyramids. The volume of dyssynergy seen in 2-D echo correlated well over a wide range with the volume of infarction determined by NBT staining.
authors.affiliation: Information Science Laboratory for Biomedicine, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nose
authors.forename: S
authors.initials: S
authors.lastname: Sanefuji
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Orita
authors.forename: M
authors.initials: M
authors.lastname: Yokota
authors.forename: K
authors.initials: K
authors.lastname: Akazawa
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D003196:Computer Graphics; D003198:Computer Simulation; D004285:Dogs; D004452:Echocardiography / Q000379:methods*; D006352:Heart Ventricles / Q000503:physiopathology; D009203:Myocardial Infarction / Q000503:physiopathology*; D014743:Videotape Recording