An antineuronal autoantibody in paraneoplastic opsoclonus.
Sera from 7 patients with paraneoplastic opsoclonus were examined for antineuronal autoantibodies. An antibody against neuronal nuclei was found in serum from a patient with breast cancer, opsoclonus, and ataxia. This antibody recognized 53- to 61-kDa and 79- to 84-kDa antigens in immunoblots of neurons. Antineuronal antibodies were not found in other patients with paraneoplastic opsoclonus.
Budde-Steffen
C
C
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Anderson
N E
NE
Rosenblum
M K
MK
Graus
F
F
Ford
D
D
Synek
B J
BJ
Wray
S H
SH
Posner
J B
JB
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001943:Breast Neoplasms / Q000150:complications / Q000276:immunology*; D002277:Carcinoma / Q000150:complications / Q000276:immunology*; D002531:Cerebellum / Q000276:immunology*; D005133:Eye Movements; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009474:Neurons / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000276:immunology*
D001323:Autoantibodies