title: Effects of botulinum toxin injections on speech in adductor spasmodic dysphonia.
abstract: Adductor spasmodic dysphonia involves an overadduction of the vocal folds during speech causing uncontrolled voice and pitch breaks and slow, effortful speech. The disorder is resistant to speech therapy and often recurs following initial benefit from unilateral recurrent laryngeal nerve resection. Botulinum toxin injections into multiple sites of the thyroarytenoid muscle on one side were performed in 16 patients. Speech was recorded prior to injection and three times post-injection. Symptoms were measured by two examiners from speech spectrograms without knowledge of speaker identity or recording session. Significant (p less than or equal to 0.03) reductions in pitch and voice breaks, phonatory aperiodicity, and sentence time occurred only when injections resulted in unilateral vocal fold paralysis. Symptoms returned with the restoration of vocal fold movement, 3 months later. Reduction in speed of swallowing without aspiration was reported in 80% of cases. Although speech volume was reduced, there were no instances of aphonia.
authors.affiliation: Speech Pathology Unit, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD 20892.
authors.forename: C L
authors.initials: CL
authors.lastname: Ludlow
authors.forename: R F
authors.initials: RF
authors.lastname: Naunton
authors.forename: S E
authors.initials: SE
authors.lastname: Sedory
authors.forename: G M
authors.initials: GM
authors.lastname: Schulz
authors.forename: M
authors.initials: M
authors.lastname: Hallett
mesh_terms: D000328:Adult; D001905:Botulinum Toxins / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement; D013060:Speech; D014827:Vocal Cords / Q000503:physiopathology; D014832:Voice Disorders / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D001905:Botulinum Toxins