Serologic evidence that Scianna null (Sc:-1,-2) red cells lack multiple high-frequency antigens.
Sera from three unrelated persons whose red cells (RBC) had the common Scianna phenotype (Sc:1,-2) contained IgG alloantibodies directed against high-frequency RBC antigens. In each case, sera or eluates or both failed to react only with Scianna null (Sc:-1,-2) cells, although an eluate from one person was compatible with a sibling's Sc:1,-2 cells. Cross-testing cells with sera or eluates, or both, from the three persons revealed no mutual compatibility. These studies show the existence of three additional RBC antigens phenotypically related to the Scianna blood group system. Sc:-1,-2 cells lack these antigens, which indicates that Scianna null cells lack multiple high-frequency antigens.
Devine
P
P
Section of Blood Bank and Transfusion Services, Mayo Clinic, Rochester, Minnesota.
Dawson
F E
FE
Motschman
T L
TL
Skradski
K J
KJ
Orsini
L
L
Moulds
J J
JJ
Taswell
H F
HF
D000368:Aged; D001789:Blood Group Antigens; D001803:Blood Transfusion; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D007519:Isoantigens / Q000032:analysis*; D008297:Male; D008875:Middle Aged
D001789:Blood Group Antigens; D007518:Isoantibodies; D007519:Isoantigens