Long-term ingestion of ammonium inhibits lysosomal proteolysis in rat liver.
A standard diet was supplemented with ammonium acetate (20%, w/w). The effect on liver protein degradation of oral administration of the ammonium diet to rats for 6 weeks has been studied. It is shown that lysosomal proteolysis is markedly decreased (by 62%) while non-lysosomal proteolysis is inhibited by 11%. This is the first report showing that ammonium ingestion inhibits liver proteolysis.
Felipo
V
V
Instituto de Investigaciones Citológicas de la Caja de Ahorros de Valencia, Centro Asociado del CSIC, Spain.
Miñana
M D
MD
Wallace
R
R
Grisolía
S
S
D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D008099:Liver / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D011480:Protease Inhibitors; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D011480:Protease Inhibitors; D011506:Proteins; C018824:ammonium acetate