[Immediate results of accelerated dosage fractionation in the radiation therapy of inoperable rectal cancer].
A comparative study of radiation therapy results was conducted in 207 patients with inoperable primary and recurring rectal cancer. Patients of the 1st group (113) were irradiated by a method of accelerated fractionation (2 times daily with a 4 h-interval at a dose of 2.5 Gy per fraction for 3 days weekly). The 2nd group of 94 patients was treated by small fractions (2-2.5 Gy once a day for 5 days weekly). The mean summary focal doses in primary tumors in the 1st and 2nd groups were 53.5 and 70.1 Gy, respectively, in recurrences--51.9 and 66.5 Gy. This method is time saving (the period of treatment was reduced by 21 days). Besides, a significant improvement of short-term results and general tolerance of irradiation with a tendency to an increase in 1-3-year survival rates of the treated patients were noted.
Chushkin
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D013997:Time Factors
Blizhaĭshie rezul'taty uskorennogo fraktsionirovaniia dozy pri luchevoĭ terapii neoperabel'nogo raka priamoĭ kishki.