[Relationship between the choline-blocking and protective actions of m-cholinolytics in chlorophos poisoning].
It was established in experiments on mice that the protective effect of metacine and atropine iodomethylate during chlorophos and acetylcholine intoxication is directly proportional to the peripheral m-cholinolytic activity of the drugs. The protective effect of the doses of metacine and atropine iodomethylate equieffective by the choline-blocking effect was equal during acetylcholine intoxication but differed during chlorophos intoxication. Atropine iodomethylate exhibited a stronger selective peripheral m-cholinolytic action than metacine.
Kosmachev
A B
AB
Petrov
V V
VV
Chigareva
S M
SM
D000109:Acetylcholine / Q000506:poisoning; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001115:Arecoline / Q000037:antagonists & inhibitors; D001286:Atropine Derivatives / Q000627:therapeutic use; D001561:Benzilates / Q000627:therapeutic use; D002794:Choline / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D051379:Mice; D010276:Parasympatholytics / Q000627:therapeutic use*; D014236:Trichlorfon / Q000506:poisoning*
D000931:Antidotes; D001286:Atropine Derivatives; D001561:Benzilates; D010276:Parasympatholytics; C053908:metacine; D001115:Arecoline; D014236:Trichlorfon; D002794:Choline; D000109:Acetylcholine
Sviaz' mezhdu kholinoblokiruiushchim i zashchitnym deĭstviem m-kholinolitikov pri otravlenii khlorofosom.