Toxicity in uremia. 2. Correlation between PTH levels and impaired aspecific immunity.
The role of PTH in depressing polynuclear leucocyte (PMN) phagocytosis in uremia was investigated. The hydrophobicity and phagocytic activity of normal PMN was tested in presence of uremic patients' serum with low (Group A) or high (Group B) levels of plasma PTH. The PMN phagocytic index was lowered by serum of both groups, but more in presence of Group B serum (p A vs B less than 0.002). Similarly, the contact angle of cells was affected more in presence of serum of patients with high PTH levels (p B vs A less than 0.003; p B vs C less than 0.002).
Esposito
R
R
Institute of Internal Medicine and Nephrology, 1st Faculty, University of Naples, Italy.
Romano-Carratelli
C
C
Lanzetti
N
N
Hohenegger
M
M
Pluvio
M
M
Capodicasa
G
G
Nuzzo
I
I
Giordano
C
C
D003603:Cytotoxins; D006801:Humans; D009504:Neutrophils / Q000276:immunology*; D010281:Parathyroid Hormone / Q000502:physiology*; D010587:Phagocytosis; D014511:Uremia / Q000276:immunology / Q000378:metabolism*
D003603:Cytotoxins; D010281:Parathyroid Hormone