Treatment of bovine lymphosarcoma with L-asparaginase.
L-asparaginase was used to treat a 4-year-old Holstein cow with lymphosarcoma that involved the spinal cord, subiliac lymph nodes, and retrobulbar space. The cow received 60,000 IU of L-asparaginase IV for a total of 4 treatments. After each treatment, the cow's condition improved, characterized by decreased weakness, decreased ataxia, a reduction in size of the left subiliac lymph node, and decreased exophthalmos. Side effects were not observed. The cow was kept alive for 57 days. This treatment offers a way of salvaging the genetic potential of valuable cows and bulls.
Masterson
M A
MA
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus 43210.
Hull
B L
BL
Vollmer
L A
LA
D000818:Animals; D001215:Asparaginase / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005260:Female; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000662:veterinary*
D001215:Asparaginase