Enhanced toxicity of the immunosuppressant ovalicin upon application to the skin.
The non-myelotoxic immunosuppressive sesquiterpene ovalicin, of fungal origin, is much more toxic when applied to the skin of animals than when injected i.v., the LD-50 in guinea pigs being 0.2 in the first case and 7 mg/kg in the second. It elicits aphagia and adipsia. It is assumed that ovalicin effects are due to slow, tissue-specific, metabolic toxification.
Stähelin
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Preclinical Research, Sandoz Ltd., Basel, Switzerland.
D000287:Administration, Topical; D000818:Animals; D006224:Cricetinae; D004334:Drug Administration Schedule; D006168:Guinea Pigs; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000633:toxicity*; D007928:Lethal Dose 50; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000008:administration & dosage / Q000633:toxicity*; D012867:Skin / Q000187:drug effects*
D007166:Immunosuppressive Agents; D012717:Sesquiterpenes; C002781:ovalicin