title: Effect of antibiotic and fluid resuscitation upon survival time in experimental intestinal ischemia.
abstract: Acute massive intestinal ischemia is an abdominal catastrophe. Prompt diagnosis and restoration of blood flow is essential; otherwise, massive intestinal resection occurs, leading to death or, in the survivors, intestinal cripples. In this study, the time of warm reversible ischemia in the canine intestine was explored. After this time was established, fluids and antibiotics were administered to note change in survival times. Massive intestinal ischemia (superior mesenteric artery was clamped) was tolerated without death for five hours (20 dogs in each group). With six hours of ischemia, a 10 per cent mortality rate occurred; with seven hours of ischemia, a 90 per cent mortality rate occurred. These dogs had a maintenance of 75 milliliters of fluid administered per hour. Using this group of dogs as the control (that is, the group with seven hour clamping time of the superior mesenteric artery with maintenance intravenously administered replacement), fluids were given to dogs in the experimental group to keep the pulmonary artery wedge pressure at a normal value (average of 300 milliliters per hour). This group of dogs had an increased survival rate of 40 per cent (ten dogs). Antibiotics were given to the dogs in the experimental group both before and after clamping, increasing the over-all survival rate to more than 80 per cent (46 dogs). Aggressive fluid replacement and antibiotic coverage may lengthen the so-called golden period in which intestinal ischemia may be reversed by revascularization.
authors.affiliation: Department of Surgery, University of Western Ontario, London.
authors.forename: W G
authors.initials: WG
authors.lastname: Jamieson
authors.forename: G
authors.initials: G
authors.lastname: Pliagus
authors.forename: S
authors.initials: S
authors.lastname: Marchuk
authors.forename: G
authors.initials: G
authors.lastname: DeRose
authors.forename: D
authors.initials: D
authors.lastname: Moffat
authors.forename: L
authors.initials: L
authors.lastname: Stafford
authors.forename: R J
authors.initials: RJ
authors.lastname: Finley
authors.forename: W
authors.initials: W
authors.lastname: Sibbald
authors.forename: B M
authors.initials: BM
authors.lastname: Taylor
authors.forename: J
authors.initials: J
authors.lastname: Duff
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002435:Cefamandole / Q000031:analogs & derivatives / Q000627:therapeutic use; D004285:Dogs; D005440:Fluid Therapy; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D011669:Pulmonary Wedge Pressure
chemical_list: D000900:Anti-Bacterial Agents; D002435:Cefamandole; C012810:cefamandole nafate