Effects of systemic L-tyrosine on dopamine release from rat corpus striatum and nucleus accumbens.
Intracerebral dialysis was used to monitor extracellular fluid from rat striatum and nucleus accumbens following the intraperitoneal administration of tyrosine. Dopamine concentrations in dialysates from both the striatum and the nucleus accumbens increased significantly in response to the tyrosine. The magnitude of the tyrosine effect was greater in the nucleus accumbens than in the striatum. Hence, mesolimbic dopaminergic neurons may be especially responsive to precursor availability.
During
M J
MJ
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
Acworth
I N
IN
Wurtman
R J
RJ
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000378:metabolism*; D014443:Tyrosine / Q000494:pharmacology*
D014443:Tyrosine; D004298:Dopamine