Effects of STS 557 on semen and sperm functions in bonnet monkey (Macaca radiata)--a preliminary report.
Intramuscular administration of STS 557 (17 alpha C-cyanomethyl-17 beta-hydroxy-estra-4,9(10)-diene-3-one) at a daily dose of 12 mg/monkey for 8 weeks induced severe oligospermia to complete azoospermia by the 9th week of initiation of treatment with concomitant decrease in the serum level of testosterone. The sperm motility was reduced from the 3rd week of treatment. Complete recovery was observed by the 14th week after withdrawal of treatment. STS 557 may have the potentiality to be used as a chemical contraceptive in the male.
Majumdar
S S
SS
Department of Reproductive Biomedicine, National Institute of Health & Family Welfare, New Delhi, India.
Sharma
R K
RK
Das
R P
RP
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D008255:Macaca radiata; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D012661:Semen / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
D003272:Contraceptive Agents, Male; D013739:Testosterone; C023635:dienogest; D009277:Nandrolone; D000135:Acid Phosphatase