Elevated environmental temperature alters the responses of the reproductive and thyroid axes of female Syrian hamsters to afternoon melatonin injections.
Female Syrian hamsters were kept in a light (14:10 h light:dark cycle, lights on 0600 h)- and temperature (22 or 30 degrees C)-controlled room; some groups were treated with an afternoon s.c. injection of melatonin (6.25, 12.5, or 25 micrograms/day) for 11 or 14 weeks. The melatonin-induced suppression of the reproductive system in hamsters maintained at 22 degrees C (as measured by vaginal cycles, uterine weights, ovarian histology, and plasma and pituitary prolactin levels) was delayed if hamsters were kept at 30 degrees C. The dose-related depression of thyroxine (T4) after melatonin injections for 14 weeks in 22 degrees C was not seen at 30 degrees C. Rather, the depression of plasma T4 and triiodothyronine (T3) seen at the end of 11 or 14 weeks of exposure to 30 degrees C without melatonin injections (vs. control levels at 22 degrees C) was offset by melatonin injections, raising T4 and T3 particularly at the lower doses. In contrast, there was no consistent effect of higher temperature alone on reproductive variables. The interactive effects of temperature and melatonin on the reproductive and thyroidal systems in female hamsters are apparently complex and probably provide a fine-tuning mechanism for the environmental control of endocrine physiology.
Reiter
R J
RJ
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.
Li
K
K
Gonzalez-Brito
A
A
Tannenbaum
M G
MG
Vaughan
M K
MK
Vaughan
G M
GM
Villanua
M A
MA
D000818:Animals; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects; D005260:Female; D005836:Genitalia, Female / Q000502:physiology*; D007267:Injections; D008550:Melatonin / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000033:anatomy & histology / Q000187:drug effects; D013696:Temperature; D013961:Thyroid Gland / Q000502:physiology*; D013963:Thyroid Hormones / Q000097:blood; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects
D013963:Thyroid Hormones; D008550:Melatonin