[Disorders in the contact phase system of blood coagulation as a cause of increased partial thromboplastin time].
Deficiency conditions in the contact phase system of the blood coagulation belong to the rare hereditary defects. Clinically, there is as a rule no inclination to haemorrhage but an increased risk of thrombosis. Therefore, the diagnosis is frequently made on the basis of incidental findings within the framework of routine examinations. Indicating sign is a greatly prolonged partial thromboplastin time (PTT) without clinical signs of haemorrhage. 3 patients with factor XII deficiency are presented and the diagnostic method in prolonged PTT is explained.
Siegert
G
G
Institut für Klinische Chemie und Laboratoriumsdiagnostik, Medizinischen Akademie Carl Gustav Carus, Dresden.
Plat
M
M
D001780:Blood Coagulation Tests; D005173:Factor XI Deficiency / Q000097:blood; D005175:Factor XII Deficiency / Q000097:blood; D006474:Hemorrhagic Disorders / Q000097:blood*; D006801:Humans; D007704:Kininogens / Q000172:deficiency; D010314:Partial Thromboplastin Time; D011288:Prekallikrein / Q000502:physiology
D007704:Kininogens; D011288:Prekallikrein
Störungen im Kontaktphasensystem der Blutgerinnung als Ursache einer verlängerten partiellen Thromboplastinzeit.