title: Clostridium botulinum toxins: nature and preparation for clinical use.
abstract: C. botulinum neurotoxins are acutely toxic materials and act by inhibiting release of the neurotransmitter acetylcholine. The specific nature of this inhibition is discussed and the preparation and purification of Type A toxin specifically for clinical use is described.
authors.affiliation: Vaccine Research and Production Laboratory, Centre for Applied Microbiology and Research, Salisbury, Wiltshire.
authors.forename: J
authors.initials: J
authors.lastname: Melling
authors.forename: P
authors.initials: P
authors.lastname: Hambleton
authors.forename: C C
authors.initials: CC
authors.lastname: Shone
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors; D001764:Blepharospasm / Q000628:therapy; D001905:Botulinum Toxins / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D002118:Calcium / Q000037:antagonists & inhibitors; D006801:Humans; D008970:Molecular Weight; D009474:Neurons / Q000187:drug effects; D009498:Neurotoxins / Q000302:isolation & purification*; D013285:Strabismus / Q000628:therapy; D013574:Synaptosomes / Q000187:drug effects
chemical_list: D009498:Neurotoxins; D001905:Botulinum Toxins; D000109:Acetylcholine; D002118:Calcium