[Renal actions of bendamustin (Cytostasan) in rats].
In adult rats influences of single doses of bendamustin (0.5, 1 or 5 mg/100 g b.wt. i.p.) on kidney function were measured (time of experimentation 8 d following administration). Bendamustin administration is followed by an increase of kidney weight caused by a higher water content of kidney tissue. An increase of plasma concentrations of creatinine and of urea following bendamustin (1 or 5 mg/100 g b.wt. i.p.) indicates a reduced excretion capacity of kidney. Bendamustin administration is not connected with a distinct proteinuria. The highest administered does (5 mg bendamustin/100 g b.wt. i.p.) caused an oliguric effect connected with a distinctly reduced renal excretion of osmotically active substances. There is a distinct diminution of renal excretion of sodium following bendamustin administration and a decrease of renal excretion of PAH can be stated. It is most likely that bendamustin can reduce the glomerular function: Following administration of 1 mg bendamustin/100 g b. wt. i.p. CIn is reduced whereas a statistically significant increase of tubular transport capacity for organic anions can be measured (TmPAH).
Bräunlich
H
H
Institut für Pharmakologie und Toxikologie, Friedrich-Schiller-Universität Jena.
Stolze
G
G
Stolze
R
R
D000818:Animals; D000069461:Bendamustine Hydrochloride; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000378:metabolism; D005260:Female; D007444:Inulin; D007668:Kidney / Q000187:drug effects*; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D009994:Osmolar Concentration; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D010130:p-Aminohippuric Acid / Q000378:metabolism
D009588:Nitrogen Mustard Compounds; D011506:Proteins; D007444:Inulin; D000069461:Bendamustine Hydrochloride; D003404:Creatinine; D010130:p-Aminohippuric Acid
Renale Wirkungen von Bendamustin (Cytostasan) bei Ratten.