Activated c-K-ras and c-N-ras oncogenes in 3-methylcholanthrene-induced BALB/c fibrosarcomas.
DNAs from fourteen fibrosarcomas induced by 3-methylcholanthrene (MCA) in BALB/c mice were analyzed for the presence of transforming oncogenes following transfection on NIH3T3 cells. Six transfection-positive DNAs contained an activated ras gene: four c-K-ras and two c-N-ras. These results demonstrate that c-K-ras is not the only oncogene of the ras family activated in MCA-induced murine fibrosarcomas as was previously indicated.
Borrello
M G
MG
Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy.
Carbone
G
G
Pierotti
M A
MA
Molla
A
A
Della Porta
G
G
D000818:Animals; D005354:Fibrosarcoma / Q000139:chemically induced / Q000235:genetics*; D008748:Methylcholanthrene; D051379:Mice; D008807:Mice, Inbred BALB C; D011519:Proto-Oncogenes; D014162:Transfection
D008748:Methylcholanthrene