Genetic polymorphism of alpha 2HS-glycoprotein in a French population. Description of two new rare variants.
A French population was investigated for genetic polymorphism of alpha 2HS-glycoprotein (A2HS; nomenclature according to Human Gene Mapping 7, Los Angeles, 1983) using isoelectric focusing and immunoblotting. Three variants were observed together with two common alleles A2HS 1 and A2HS 2, whose frequencies were significantly different from the data in Canadians and Egyptians. An anodal variant to A2HS 1 was identical to a variant with two different nomenclatures reported by three different groups, indicating that there is a confusion in the A2HS nomenclature. The others were new variants with cathodal isoelectric points to A2HS 2 in the native state.
Robinet-Lévy
M
M
Institut d'Hématologie, Centre de Transfusion Sanguine, Montpellier, France.
Yuasa
I
I
Umetsu
K
K
Ikebuchi
J
J
D000483:Alleles; D001798:Blood Proteins / Q000235:genetics*; D005602:France; D005787:Gene Frequency; D006801:Humans; D007525:Isoelectric Focusing; D010641:Phenotype; D011110:Polymorphism, Genetic; D060749:alpha-2-HS-Glycoprotein
C556354:AHSG protein, human; D001798:Blood Proteins; D060749:alpha-2-HS-Glycoprotein