title: Simulation of the segmental burst generating network for locomotion in lamprey.
abstract: Recently a segmental network of inhibitory and excitatory interneurones, which are active during locomotion, has been described in the lamprey, a lower vertebrate. The interactions between the different neurones were established by paired intracellular recordings. A computer simulation of the segmental network has been performed, which shows that with the established neuronal connectivity rhythmic alternating burst activity can be generated within the upper part of the normal physiological range of locomotion. Three neurones of each kind were used (altogether 18 neurones). As shown previously the lower frequency range used in locomotion most likely depends on an activation of voltage-dependent N-methyl-D-aspartate (NMDA) receptors, which could, however, not be simulated with the present neuronal models.
authors.affiliation: Nobel Institute for Neurophysiology, Karolinska Institute, Department of Computer technology and Numerical analysis, Royal College of Technology, Stockholm, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Grillner
authors.forename: J T
authors.initials: JT
authors.lastname: Buchanan
authors.forename: A
authors.initials: A
authors.lastname: Lansner
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004525:Efferent Pathways / Q000502:physiology; D005399:Fishes / Q000502:physiology*; D007395:Interneurons / Q000502:physiology; D007798:Lampreys / Q000502:physiology*; D008124:Locomotion; D008959:Models, Neurological; D009046:Motor Neurons / Q000502:physiology