title: Herpes simplex virus infection of the hand. Clinical features and management.
abstract: Herpes simplex virus (HSV) infection of the hand occurs predominantly in three different population groups. Young adults with a recurrent HSV II infection of the hand account for the majority of cases. A prodromal phase of up to 72 hours and a recurrence of seven to 10 days' duration occasionally associated with lymphangitis, lymphadenopathy, and lymphedema are characteristic. HSV I infection of the hand classically occurs in children with herpetic stomatitis and in health care workers infected during patient care delivery. In health care workers, the infection may last 21 to 28 days and be associated with severe pain and lymphangitis. Recurrences appear uncommon in HSV I infections. Primary infection is usually managed conservatively. Vesicle drainage for pain relief and antiviral therapy with acyclovir may be of value. For recurrent infections, acyclovir, 800 mg orally, twice daily, initiated during the prodrome in an open study of eight patients appeared effective in aborting the attack. Evaluation of long-term suppression in recurrent HSV infection of the hand is in progress.
authors.affiliation: Department of Medicine, University of Calgary, Alberta, Canada.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gill
authors.forename: J
authors.initials: J
authors.lastname: Arlette
authors.forename: D L
authors.initials: DL
authors.lastname: Tyrrell
authors.forename: K A
authors.initials: KA
authors.lastname: Buchan
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D005260:Female; D006229:Hand Dermatoses / Q000175:diagnosis / Q000188:drug therapy; D006561:Herpes Simplex / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007065:Idoxuridine / Q000627:therapeutic use; D007223:Infant; D012008:Recurrence
chemical_list: D007065:Idoxuridine; D000212:Acyclovir