Effect of promethazine on the metabolism of chloroquine.
Co-administration of promethazine hydrochloride and chloroquine phosphate resulted in increased blood levels of chloroquine and its metabolites. However, there is no statistical difference between the means obtained for the initial rate of excretion and the total drug excreted within three hours.
Ehiemua
A O
AO
University of Ife, Ile-Ife, Nigeria.
Komolafe
O O
OO
Oyedeji
G A
GA
Olamijulo
S K
SK
D000328:Adult; D002738:Chloroquine / Q000378:metabolism* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008297:Male; D011398:Promethazine / Q000494:pharmacology*
D002738:Chloroquine; D011398:Promethazine