Role of compensatory gain in Eimeria acervulina-induced liver copper accumulation in chicks.
An investigation was conducted to determine whether the Eimeria acervulina-induced increase in liver Cu accumulation in chicks is the result of compensatory gain that accompanies the recovery phase of infection. In experiment 1, chicks inoculated one time with 1 X 10(6) sporulated E. acervulina oocysts had a faster rate of compensatory gain than chicks inoculated serially on three occasions with 4 X 10(5) oocysts. However, liver Cu accumulation was nearly identical for the two infection regimes. In experiment 2, rate of compensatory gain and liver Cu accumulation was compared in 1) ad libitum-fed chicks; 2) restricted-fed chicks fed 40% of ad libitum intake followed by ad libitum intake; 3) coccidiosis-infected chicks, 1 X 10(6) oocysts on d 2 of the experiment; and 4)-6) the same as 1)-3), respectively, but fed 500 mg Cu/kg diet. Restricted-fed chicks had a higher rate of compensatory gain than coccidiosis-infected chicks. Liver Cu accumulation was sixfold higher in coccidiosis-infected chicks than in restricted-fed chicks, however. In addition, liver Cu accumulation of the control (uninfected) chicks and the 40% restricted-fed chicks was identical. Thus compensatory gain during the recovery phase of coccidiosis is not responsible for the coccidiosis-induced increase in liver Cu accumulation.
Giraldo
C
C
Department of Animal Science, Louisiana State University Agricultural Center, Baton Rouge 70803.
Southern
L L
LL
D000818:Animals; D001835:Body Weight; D002645:Chickens / Q000254:growth & development; D003048:Coccidiosis / Q000378:metabolism / Q000662:veterinary*; D003300:Copper / Q000378:metabolism*; D004032:Diet; D004386:Duodenum / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000378:metabolism*; D011201:Poultry Diseases / Q000378:metabolism*
D003300:Copper