Effect of high doses of dietary vitamin E on the concentrations of vitamin E in several brain regions, plasma, liver, and adipose tissue of rats.
The object of this study was to assess the influence of high levels of dietary vitamin E on vitamin E concentrations in specific areas of the brain. Four-week-old male rats were fed vitamin E-deficient, control, and high-vitamin E (1,000 IU/kg) diets for 4 months. Concentrations of alpha-tocopherol in serum, adipose tissue, liver, cerebrum, cerebellum, and striatum were determined by liquid chromatography with fluorescence detection. In the high-vitamin E group, alpha-tocopherol concentrations in cerebrum, cerebellum, and striatum increased uniformly to 1.4-fold of values in controls; serum, adipose tissue, and liver attained even higher concentrations: 2.2-, 2.2-, and 4.6-fold, respectively, of control values. As observed before, brain levels of alpha-tocopherol were somewhat resistant to vitamin E deficiency, in contrast to the peripheral tissues.
Vatassery
G T
GT
Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Minneapolis, MN 55417.
Brin
M F
MF
Fahn
S
S
Kayden
H J
HJ
Traber
M G
MG
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004032:Diet; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010949:Plasma; D051381:Rats; D014810:Vitamin E / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology
D014810:Vitamin E