title: Involvement of central histamine receptors in corticosterone secretion induced by intraventricular administration of morphine.
abstract: The effect of intracerebroventricular (i.c.v.) administration of morphine on corticosterone secretion was studied in conscious, unstressed rats. A dose-dependent increase in serum corticosterone levels was observed 1 h after morphine injection. The corticosterone response to morphine was antagonized in a dose-dependent manner, and at larger dose almost abolished, by i.c.v. pretreatment of rats with naloxone, an opioid receptor antagonist. Intraventricular pretreatment of rats with mepyramine and cimetidine, the histamine H1- and H2-receptor antagonists, significantly diminished the corticosterone response to morphine. These results suggest that central opioid receptors are involved in the stimulating effect of morphine on the hypothalamo-pituitary-adrenocortical axis. Central histamine H1- and H2-receptors seem to be substantially involved in the stimulatory effect of morphine on corticosterone secretion in conscious, unstressed rats.
authors.affiliation: Institute of Pharmacology, Polish Academy of Sciences, Kraków.
authors.forename: B
authors.initials: B
authors.lastname: Cetera
authors.forename: J
authors.initials: J
authors.lastname: Bugajski
authors.forename: A
authors.initials: A
authors.lastname: Gadek-Michalska
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011968:Receptors, Histamine / Q000187:drug effects* / Q000502:physiology
chemical_list: D011968:Receptors, Histamine; D009270:Naloxone; D009020:Morphine; D003345:Corticosterone