Myocardiotoxicity of 5 fluorouracil.
We report a case of specific myocardiotoxicity due to 5 F.U. not previously described in man. A 41-year-old man was admitted to the ICU for heart and renal failure, appearing 24 h after 5 days treatment with 5 F.U. and cis-platinum. Dopamine was necessary to maintain blood pressure. Two-D echocardiography and a right heart catheterisation confirmed the alteration of myocardial contractility. After 2 weeks a complete cardiac recovery occurred.
Coronel
B
B
Département de Néphrologie, Hôpital Edouard Herriot, Lyon, France.
Madonna
O
O
Mercatello
A
A
Caillette
A
A
Moskovtchenko
J F
JF
D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced*; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy; D008297:Male
D005472:Fluorouracil