Nonedited 1H NMR lactate/n-acetyl aspartate ratios and the in vivo determination of lactate concentration in brain.
The 1H lactate/n-acetyl aspartate ratio is commonly used for the quantitation of brain lactate under pathological conditions. We demonstrate that the intensity of the lactate methyl region in water-suppressed, nonedited 1H spectra increases following mild brain trauma as a result of factors other than lactate accumulation.
Vink
R
R
Department of Neurology, V.A. Medical Center, San Francisco, California 94121.
McIntosh
T K
TK
Faden
A I
AI
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D051381:Rats; D011919:Rats, Inbred Strains
D007773:Lactates; D001224:Aspartic Acid; C000179:N-acetylaspartate