[Pharmacological studies on the effects of some traditional Chinese medicines on gastric functions. (3) The effects of oren-gedoku-to (OGT), san'o-syasin-to (SST), antyu-san (AS) and dai-saiko-to (DST) on ethanol- and aspirin-induced gastric lesions in rats].
The effects of OGT, SST, AS and DST on ethanol- and aspirin-induced gastric hemorrhagic lesions in rats were studied in comparison with those of sucralfate, 16,16-dimethyl-prostaglandin E2 (DMPGE2) and cimetidine. 1) OGT given orally at doses of 25-250 mg/kg protected gastric mucosa from injury induced by ethanol or aspirin. 2) SST prevented the appearance of aspirin-induced lesions at doses more than 25 mg/kg, and ethanol-induced lesions at 250 and 500 mg/kg. 3) AS and DST inhibited aspirin-induced lesions at more than 250 mg/kg and inhibited ethanol-induced lesions at 500 mg/kg. 4) Sucralfate (500 mg/kg) significantly prevented ethanol- and aspirin-induced lesions. DMPGE2 significantly inhibited ethanol-induced lesions at doses more than 0.1 micrograms/kg, and it inhibited aspirin-induced lesions dose-dependently at doses ranging from 0.1 to 5 micrograms/kg. Cimetidine significantly inhibited aspirin-induced lesions at doses of 10-250 mg/kg and inhibited ethanol-induced lesions at doses of 100 and 250 mg/kg. These results suggest that OGT, SST, AS and DST have a prophylactic effect on ulcerogenics, and the potency of OGT may be superior to those of SST, AS and DST.
Takase
H
H
Kanebo Co., Ltd., Kampo Research Center, Osaka, Japan.
Imanishi
K
K
Miura
O
O
Yumioka
E
E
Watanabe
H
H
D000818:Animals; D001241:Aspirin / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D000431:Ethanol / Q000009:adverse effects*; D008297:Male; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control
D004365:Drugs, Chinese Herbal; D000431:Ethanol; D001241:Aspirin