title: Klossiella equi induced tubular nephrosis and interstitial nephritis in a pony.
abstract: Heavy renal infection in a pony with Klosiella equi resulted in moderate diffuse tubular nephrosis and tubular rupture. Multifocal non-suppurative interstitial nephritis was associated with ruptured tubules. Ultrastructural examination of sporoblasts demonstrated both the presence of a bilaminated membrane encasing organisms and nuclear budding. Endogenous corticosteroid production probably led to the development of an immune-compromized state and subsequent extensive parasitic replication.
authors.affiliation: Department of Veterinary Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
authors.forename: W I
authors.initials: WI
authors.lastname: Anderson
authors.forename: C A
authors.initials: CA
authors.lastname: Picut
authors.forename: M E
authors.initials: ME
authors.lastname: Georgi
mesh_terms: D000302:Adrenal Cortex / Q000469:parasitology / Q000473:pathology; D000818:Animals; D003048:Coccidiosis; D003458:Cryptosporidium / Q000648:ultrastructure; D006734:Horse Diseases / Q000209:etiology* / Q000469:parasitology / Q000473:pathology; D006736:Horses; D006965:Hyperplasia / Q000150:complications; D009395:Nephritis, Interstitial / Q000150:complications / Q000209:etiology / Q000662:veterinary*; D009401:Nephrosis / Q000150:complications / Q000209:etiology / Q000662:veterinary*