Enhancement of theophylline clearance by intravenous albuterol.
Co-administration of intravenous albuterol and theophylline resulted in increased theophylline clearance in a child with severe asthma. This required a threefold increase in theophylline dosage to maintain therapeutic serum theophylline concentrations. The possible effect of intravenous albuterol on theophylline metabolism was further supported by a 50 percent decrease in theophylline clearance upon discontinuation of albuterol and a second increase in its clearance when albuterol was readministered. To the best of our knowledge, this is the first documentation of enhanced theophylline clearance by albuterol.
Amirav
I
I
Department of Pediatrics, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.
Amitai
Y
Y
Avital
A
A
Godfrey
S
S
D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D013224:Status Asthmaticus / Q000378:metabolism*; D013806:Theophylline / Q000493:pharmacokinetics*
D013806:Theophylline; D000420:Albuterol