Co-administered oral metoclopramide does not enhance the rate of absorption of oral diazepam.
Intravenous metoclopramide is known to increase the rate of absorption of oral diazepam if administered at the same time. It has been suggested that oral metoclopramide has the same effect. In this study, six healthy volunteers received oral diazepam (0.2 mg/kg) on two separate occasions, either alone or with oral metoclopramide (10 mg), given simultaneously. In contrast to the effects of intravenous metoclopramide, oral metoclopramide did not increase the rate of absorption of oral diazepam.
Chapman
M H
MH
Department of Anaesthetics, Christchurch Hospital, New Zealand.
Woolner
D F
DF
Begg
E J
EJ
Atkinson
H C
HC
Sharman
J R
JR
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D003975:Diazepam / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation
D008787:Metoclopramide; D003975:Diazepam