Role of catecholamines in regulation by feeding of energy balance following chronic exercise in rats.
Two experiments examined the contribution of the two catecholamines--epinephrine (EPI) and norepinephrine (NE)--to the control of food intake and body weight gain in male rats during chronic exercise. Urinary excretion of both catecholamines rose significantly and was positively correlated to food intake inhibition (NE, n = 54, r = 0.394, p less than 0.01; EPI, n = 54, r = 0.428, p less than 0.01). Oral ingestion of the non-selective beta-adrenoceptor blocking drug, pindolol, abolished the food intake reduction induced by exercise. Furthermore, rats that were treated with pindolol gained weight at a higher rate than untreated rats. These findings are consistent with the idea that catecholamines contribute to post-exercise inhibition of food intake and reduction of body weight in male rats. However, the exact physiological mechanism of catecholamine-induced decrease in food intake remains to be elucidated.
Guilland
J C
JC
Laboratoire de Physiologie, Faculté de Médecine, Dijon, France.
Moreau
D
D
Genet
J M
JM
Klepping
J
J
D000818:Animals; D001835:Body Weight; D004435:Eating; D004734:Energy Metabolism; D004837:Epinephrine / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000502:physiology
D011941:Receptors, Adrenergic; D009638:Norepinephrine; D004837:Epinephrine