Hepatic clearances of antipyrine, indocyanine green, and galactose in normal subjects and in patients with chronic liver diseases.
Blood clearance of antipyrine, indocyanine green, and galactose were measured to evaluate the alterations of effective hepatic blood flow and hepatic intrinsic clearances in chronic liver diseases. Galactose blood clearance, which may be taken as effective hepatic blood flow, decreased by approximately 30% in patients with cirrhosis (12.49 +/- 0.76 ml/min/kg; mean +/- SE; n = 17) compared with normal subjects (18.17 +/- 1.03 ml/min/kg; n = 5). In patients with cirrhosis, intrinsic clearances of antipyrine (0.178 +/- 0.014 ml/min/kg; n = 17) and indocyanine green (6.19 +/- 1.38 ml/min/kg; n = 7) showed 61% and 85% reduction, respectively, compared with those of normal subjects (0.462 +/- 0.048 ml/min/kg; n = 5; 41.72 +/- 7.75 ml/min/kg; n = 5). Considering that indocyanine green and antipyrine are eliminated by different hepatic mechanism, these mechanisms may not be equally sensitive to decrements in hepatic function. In addition, fractional reductions of intrinsic clearances for these compounds are thus much greater than that of effective hepatic blood flow.
Kawasaki
S
S
Second Department of Surgery, Faculty of Medicine, University of Tokyo, Japan.
Sugiyama
Y
Y
Iga
T
T
Hanano
M
M
Beppu
T
T
Sugiura
M
M
Sanjo
K
K
Idezuki
Y
Y
D000328:Adult; D000368:Aged; D000983:Antipyrine / Q000097:blood / Q000493:pharmacokinetics*; D002908:Chronic Disease; D005260:Female; D005690:Galactose / Q000493:pharmacokinetics*; D005693:Galactosemias / Q000175:diagnosis; D006505:Hepatitis / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007208:Indocyanine Green / Q000097:blood / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism*; D008102:Liver Circulation; D008103:Liver Cirrhosis / Q000378:metabolism / Q000503:physiopathology; D008107:Liver Diseases / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008954:Models, Biological
D007208:Indocyanine Green; D000983:Antipyrine; D005690:Galactose