[The effect of nootropics on impared learning performance in a pole jumping test after repeated ethanol administration].
The influence of ethanol administration (4 ml of 10% ethanol/d p.o.) for 6 and 13 d respectively, on learning behaviour of rats has been studied using an active avoidance reaction. While the formation of an active avoidance reaction was only insignificantly impaired by the application of ethanol for 6 d, the learning performance of rats showed a significant deficit after 13d of ethanol ingestion. Repeated nootropic pretreatment (d11 to 14 following first ethanol dose b.i.d.) resulted in an attenuation of learning deficits. The nootropics piracetam (100 mg/kg i.p.) methyl-glucamine orotate (225 mg/kg i.p.), meclofenoxate hydrochloride (100 mg/kg i.p.), pyritinol (100 mg/kg i.p.) and dihydroergotoxine mesilate (1 mg/kg i.p.) showed to be effective. The possible mechanism of action is discussed.
Hoffmann
W
W
Hauptabteilung Klinik und Pharmakologie, VEB Arzneimittelwerk Dresden.
Rostock
A
A
Bartsch
R
R
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011619:Psychotropic Drugs; D000431:Ethanol
Der Einfluss von Nootropika auf eine durch wiederholte Ethanolgabe ausgelöste Lernleistungsminderung bei Ratten am Stabsprungtest.