title: Occult carcinomas of the thyroid. Evaluation of 1,020 sequential autopsies.
abstract: In a sequence of 1,020 autopsies, all thyroid glands were thoroughly examined during a two-year period. Fifty-seven percent of the thyroid glands had no gross or histologic changes; approximately 22% were more or less goitrous. In 63 of 1,020 (6.2%) thyroid glands, a clinically latent carcinoma was detected. The greatest diameter of tumors measured microscopically ranged between 0.5 and 10.5 mm. Sixty-nine percent of the carcinomas were found by excision of a local change of tissue visible through close examination by the naked eye. All but one carcinoma were of papillary type, the one exception being a C-cell carcinoma. Multicentricity was found in 46% and regional lymph node metastases in 14%. There was no significant predilection of sex or age. It was concluded that these tumors have no propensity to increase to a clinically apparent thyroid disease.
authors.affiliation: Department of Pathology, Medical School, Hannover, Federal Republic of Germany.
authors.forename: W
authors.initials: W
authors.lastname: Lang
authors.forename: H
authors.initials: H
authors.lastname: Borrusch
authors.forename: L
authors.initials: L
authors.lastname: Bauer
mesh_terms: D000236:Adenoma / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009382:Neoplasms, Unknown Primary / Q000473:pathology*; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology*