A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs.
The CTF/NF-I group of cellular DNA binding proteins recognizes the sequence GCCAAT and is implicated in eukaryotic transcription as well as DNA replication. Molecular analysis of human CTF/NF-I complementary DNA clones reveals multiple messenger RNA species containing alternative coding regions, apparently as a result of differential splicing. Expression and functional analysis establish that individual gene products can bind to GCCAAT recognition sites and serve both as promoter-selective transcriptional activators and as initiation factors for DNA replication.
Santoro
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C
Howard Hughes Medical Institute, Department of Biochemistry, University of California, Berkeley.
Mermod
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N
Andrews
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PC
Tjian
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R
D000256:Adenoviridae / Q000235:genetics; D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000378:metabolism; D012326:RNA Splicing; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic; D014779:Virus Replication
D004268:DNA-Binding Proteins; D014157:Transcription Factors; D004247:DNA; D012319:RNA Polymerase II