title: Effect of irradiated Ascaridia galli eggs on growth and cell-mediated immune responses in chickens.
abstract: Growth and cell-mediated immune (CMI) responses were studied in 7-day-old chicks given orally 1000 irradiated (12.5 kR) or normal infective eggs of Ascaridia galli. Chicks immunised with irradiated eggs showed normal weight gains. CMI responses, as assessed by dinitrofluorobenzene (DNFB)-induced contact and delayed hypersensitivity reactions, were enhanced in the immunised group as compared with healthy controls, suggesting stimulation of CMI responses due to irradiation of A. galli eggs. CMI as well as growth responses were, however, found to be depressed in the birds administered normal infective eggs of A. galli. The present study highlights the role of the CMI response in protection against A. galli infection.
authors.affiliation: Division of Parasitology, Indian Veterinary Research Institute, Uttar Pradesh.
authors.forename: H C
authors.initials: HC
authors.lastname: Malviya
authors.forename: P
authors.initials: P
authors.lastname: Dwivedi
authors.forename: T K
authors.initials: TK
authors.lastname: Varma
mesh_terms: D000818:Animals; D001197:Ascaridia / Q000276:immunology* / Q000528:radiation effects; D001198:Ascaridiasis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D001835:Body Weight; D002645:Chickens / Q000254:growth & development / Q000276:immunology / Q000469:parasitology*; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007114:Immunization / Q000662:veterinary; D009349:Nematode Infections / Q000662:veterinary*; D010063:Ovum / Q000276:immunology / Q000528:radiation effects; D011201:Poultry Diseases / Q000276:immunology* / Q000517:prevention & control