title: The effect of indication on the risk of hypersensitivity reactions associated with tolmetin sodium vs other nonsteroidal antiinflammatory drugs.
abstract: A retrospective cohort study using 1980-1984 Medicaid billing data from 3 US states was performed to assess the relative risk of hypersensitivity reactions from different nonsteroidal antiinflammatory drugs (NSAID). Comparing tolmetin sodium to other NSAID, pooling the data across the 3 US states using the Mantel-Haenszel procedure, gave an overall relative risk (95% confidence interval) of 1.1 (0.8-1.4). After adjusting for multiple potential confounding variables using logistic regression, an odds ratio (95% confidence interval) of 0.9 (0.6-1.2) was observed. These data do not confirm previous suggestions that use of tolmetin is associated with a higher risk of hypersensitivity reactions than use of other NSAID.
authors.affiliation: Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-6095.
authors.forename: B L
authors.initials: BL
authors.lastname: Strom
authors.forename: J L
authors.initials: JL
authors.lastname: Carson
authors.forename: R
authors.initials: R
authors.lastname: Schinnar
authors.forename: E
authors.initials: E
authors.lastname: Sim
authors.forename: M L
authors.initials: ML
authors.lastname: Morse
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D011758:Pyrroles / Q000009:adverse effects*; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D014046:Tolmetin / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011758:Pyrroles; D014046:Tolmetin