title: Longitudinal analysis of infantile growth in children with celiac disease.
abstract: The aim of the present study was to describe linear growth of infants with celiac disease, using the "ICP-growth model". Supine length during the first three years of life was studied longitudinally in 63 infants with diagnosed celiac disease. "Undisturbed" linear growth was seen during the first six postnatal months followed by reduced growth during the second half of the first year. After 1.5 years of age a pattern of catch-up growth was observed, leading to an average attained length at 3 years of age similar to that of the controls. According to the "ICP-growth model", normal linear growth can mathematically be represented during the first 3 years of life by an Infancy component with the addition of a Childhood component, the latter acting from the second half of the first postnatal year. The onset of the Childhood component (assumed to represent the age at which growth hormone begins to influence linear growth significantly) was delayed by about an average of 3 months, which is in agreement with the observed reduction in gain during the second half of the first year of life. Children suffering from celiac disease and with "late" onset of the Childhood component were shorter at 1, 2 and 3 years of age than those with "normal" onset. The results of this investigation show that ICP-based growth charts are helpful in detecting and monitoring growth for children with celiac disease, and indicate a possible mechanism whereby malabsorption (and perhaps secondary malnutrition) leads to reduced growth velocity.
authors.affiliation: Department of Anatomy, University of Göteborg, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Karlberg
authors.forename: J I
authors.initials: JI
authors.lastname: Henter
authors.forename: E
authors.initials: E
authors.lastname: Tassin
authors.forename: B S
authors.initials: BS
authors.lastname: Lindblad
mesh_terms: D000367:Age Factors; D002446:Celiac Disease / Q000150:complications / Q000503:physiopathology*; D002675:Child, Preschool; D005260:Female; D006128:Growth; D006801:Humans; D007223:Infant; D007231:Infant, Newborn / Q000254:growth & development*; D008297:Male; D012016:Reference Values; D012737:Sex Factors