title: Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris.
abstract: The MeOH extract of Senecio vulgaris L., administered po to rats on Days 1-10 postcoitum, significantly decreased the number of normal fetuses per pregnant rat found at autopsy on Day 16. Additional experiments showed a similar activity for its hepatotoxic constituents senecionine and senecionine N-oxide, suggesting that the latter two compounds were probably responsible for the effect seen with the extract. No antifertility effects were seen in MeOH extract-treated hamsters.
authors.affiliation: Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.
authors.forename: Z B
authors.initials: ZB
authors.lastname: Tu
authors.forename: C
authors.initials: C
authors.lastname: Konno
authors.forename: D D
authors.initials: DD
authors.lastname: Soejarto
authors.forename: D P
authors.initials: DP
authors.lastname: Waller
authors.forename: A S
authors.initials: AS
authors.lastname: Bingel
authors.forename: R J
authors.initials: RJ
authors.lastname: Molyneux
authors.forename: J A
authors.initials: JA
authors.lastname: Edgar
authors.forename: G A
authors.initials: GA
authors.lastname: Cordell
authors.forename: H H
authors.initials: HH
authors.lastname: Fong
mesh_terms: D000818:Animals; D003270:Contraceptive Agents / Q000032:analysis*; D006224:Cricetinae; D005260:Female; D008297:Male; D008647:Mesocricetus; D010947:Plants, Toxic; D011247:Pregnancy; D011763:Pyrrolizidine Alkaloids / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012674:Senecio / Q000032:analysis*
chemical_list: D003270:Contraceptive Agents; D011763:Pyrrolizidine Alkaloids; C056840:senecionine N-oxide; C009237:senecionine