[State of anti- and pro-oxidative systems during the healing of aseptic and infected wounds in animal experiments].
Time-course changes in the specific activity of superoxide dismutase (SOD) and hydroperoxides were studied in granulation tissue and blood serum of 230 Wistar male rats weighing 200-210 g with simulated aseptic and infected surface wounds before and 1-10, 12, 15 days after the operation. Differences in the level range of SOD and hydroperoxides specific activity were demonstrated in tissues and sera. The dependence of hydroperoxide levels on the wound stage, as well as the dependence of SOD specific activity time-course on the character and severity of wound were stated. The allowances should be made of those differences in the shifts observed in anti- and pro-oxidative systems during wound healing when corrective therapeutic measures are considered.
Zakharov
V V
VV
Mamedov
L A
LA
Nikolaev
A V
AV
Gudz'
T I
TI
Kudriashov
Iu B
IuB
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D006097:Granulation Tissue / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism*; D013530:Surgical Wound Infection / Q000201:enzymology / Q000378:metabolism* / Q000517:prevention & control; D013997:Time Factors; D014945:Wound Healing
D000975:Antioxidants; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase
Sostaianie anti- i prooksidantnoĭ sistem pri zazhivlenii asepticheskikh i infitsirovannykh ran v éksperimente.