[Possibility of the neoplastic transformation of thyroid gland cells in the graft vs host reaction].
The experiments were carried out on 60 first generation hybrids. Acute systemic "graft-versus-host" reaction (GVHR) was induced in (CBA X C57B1/6) X 60 X 10(6) hybrids by intravenous administration of spleen cells from C57B1/6 parents. Thyroid glands were examined on the 3rd, 10th and 24th days of GVHR. Chronic GVHR was studied in accordance with routine model. (C57B1/6 X DBA/2) hybrids were given 50 X 10(6) spleen cells from DBA/2 parents. Thyroid glands were investigated 6 months after GVHR induction. On the 10th day of GVHR histological examination revealed that follicular-like adenoma tumours with pronounced cellular abnormalities tended to appear in thyroid gland. In a chronic form of GVHR the histological pattern corresponds to that of follicular cancer.
Kozlova
T D
TD
Zarudin
V V
VV
Kozlov
N B
NB
D000236:Adenoma / Q000209:etiology* / Q000473:pathology; D000818:Animals; D002471:Cell Transformation, Neoplastic; D006087:Graft vs Host Reaction; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000637:transplantation*; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000473:pathology; D013997:Time Factors
O vozmozhnosti opukholevoĭ transformatsii kletok shchitovidnoĭ zhelezy pri reaktsii transplantat protiv khoziaina.