Effect of intestinal ischemia on pulmonary surfactant. An experimental study.
The infective factor seems to be very important in the physiopathology of intestinal ischaemia syndrome, as we suggested in previous research works, and is probably responsible for the disturbances observed in pulmonary surfactant. In the present research project, 48 mongrel dogs were studied under different situations of experimental intestinal ischaemia (arterial, venous and revascularization) after laparotomy and the pulmonary surfactant was determined in all cases. We conclude that the observed changes in phospholipids (phosphatidylglycerol and phosphatidylinositol particularly) can be directly related to the infective factor and important enough to induce physicochemical alterations of the surfactant and subsequently pulmonary function.
Gómez Alonso
A
A
Departamento de Cirugía, Facultad de Medicina, Universidad de Salamanca, Spain.
Cuadrado Idoyaga
F
F
Villar Galan
J L
JL
Pérez Garcia
A
A
Rodriguez Morán
M
M
Milicua
M
M
Cabezas
J A
JA
Pérez Gonzalez
M N
MN
D000818:Animals; D004285:Dogs; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000503:physiopathology*; D008641:Mesenteric Vascular Occlusion / Q000503:physiopathology; D010715:Phosphatidylglycerols / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D011663:Pulmonary Surfactants / Q000378:metabolism*; D013997:Time Factors
D010715:Phosphatidylglycerols; D010716:Phosphatidylinositols; D011663:Pulmonary Surfactants