Alteration of insulin-binding receptors in non-insulin dependent diabetes of the young.
The behaviour of insulin binding receptors is rather unelucidated in non-insulin-dependent diabetes mellitus of the young. Authors in continuing their previous work studied the behaviour of insulin binding receptors of erythrocytes and monocytes in 9 MODY patients. They observed that specific insulin binding of circulating blood cells was significantly decreased in all cases as compared to the controls despite of a good state of metabolism (in the case of erythrocytes 4.63 +/- 1.1% vs. 6.03 +/- 1.7%, p less than 0.05, in the case of monocytes 2.3 +/- 1.2% vs. 3.6 +/- 1.4%, p less than 0.05). The lower value of insulin binding resulted from the decrease of receptor concentrations (in the case of erythrocytes 2.36 +/- 0.78 pmol/l vs. 3.81 +/- 1.14 pmol/l, p less than 0.05).
Kautzky
L
L
Korányi, National Institute of Tuberculosis and Pulmonology, Budapest/Hungary.
Korányi
L
L
Halmos
T
T
Orosz
A
A
D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology / Q000503:physiopathology*; D004912:Erythrocytes / Q000032:analysis / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008297:Male; D009000:Monocytes / Q000032:analysis / Q000378:metabolism / Q000648:ultrastructure; D011972:Receptor, Insulin / Q000502:physiology*
D011972:Receptor, Insulin