Decrease of serum triglyceride in normal rat fed with 2000 ppm aluminum diet for 67 days. II. Feeding young and adult rats a sucrose diet with addition of aluminum hydroxide and aluminum potassium sulfate.
To confirm the hypotriglyceridemic effect of aluminum (Al), male weanling and adult Wistar rats were fed sucrose diets with the addition of aluminum hydroxide (Al(OH)3) or aluminum potassium sulfate (AlK(SO4)2) for 67 days. As in the foregoing report (C. Sugawara, N. Sugawara, H. Kiyosawa, and H. Miyake, Fundam. Appl. Toxicol. 10, 607-615), no Al-induced anemia or hypophosphatemia was observed and serum Al did not exceed 20 ng/ml. Serum triglyceride (TG) was decreased by aluminum. Serum TG was significantly correlated with the serum nonesterified fatty acid (NEFA) concentration in both the Young groups (R = 0.757, n = 22, p less than 0.01) and the Adult groups (R = 0.727, n = 19, p less than 0.01). Neither serum cholesterol nor phospholipids was affected by Al ingestion. Aluminum caused a decrease in hepatic glycogen in all groups, but the decrease was significant only in Adult groups. Glycerol tri[9,10(n)-3H]oleate was administered by gastric tube into rats fed for 81 days with experimental diets. In all the Al-treated groups serum 3H was significantly greater than in control groups at 3 hr after intubation. At 24 hr after intubation, serum 3H did not differ between Control and Al-treated groups. Total 3H at 24 hr found in serum, liver, and epididymal adipose tissue was not changed significantly by Al feeding. These effects were observed without measurable increase of Al in the serum.(ABSTRACT TRUNCATED AT 250 WORDS)
Sugawara
C
C
Department of Public Health, Sapporo Medical College, Japan.
Sugawara
N
N
Kiyosawa
H
H
Miyake
H
H
D000534:Alum Compounds / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity; D000535:Aluminum / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity*; D000536:Aluminum Hydroxide / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013395:Sucrose / Q000008:administration & dosage; D014018:Tissue Distribution; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism; D014304:Triolein / Q000378:metabolism
D000534:Alum Compounds; D008055:Lipids; D008112:Liver Glycogen; D014280:Triglycerides; D014304:Triolein; D013395:Sucrose; D000536:Aluminum Hydroxide; D000535:Aluminum