Synthesis of prostaglandin E by peritoneal macrophages from NZB/W mice.
Peritoneal macrophages from NZB/W (murine lupus) mice spontaneously produce less prostaglandin E (PGE) than peritoneal macrophages from immunologically normal mice. Reduced PGE synthesis is seen as early as 2 months of age and becomes more profound as disease progresses. It is suggested that impaired production of PGE by peritoneal macrophages from NZB/W mice may account in part for abnormal macrophage function observed in these animals.
Dore-Duffy
P
P
Department of Neurology, University of Connecticut Health Center, Farmington 06032.
Guha
A
A
Rothman
B L
BL
Zurier
R B
RB
D000367:Age Factors; D000818:Animals; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008814:Mice, Inbred NZB; D009393:Nephritis / Q000378:metabolism; D010529:Peritoneal Cavity / Q000166:cytology; D011458:Prostaglandins E / Q000096:biosynthesis*
D011458:Prostaglandins E