Direct stimulatory effect of growth hormone on DNA synthesis of fetal chicken osteoblasts in culture.
GH action on cartilage is thought to be mainly mediated through the somatomedins produced by the liver. However, recent studies using cultured chondrocytes also point to a direct mitogenic action of GH. Besides, a direct action of GH on fetal rat tibiae has been demonstrated. This study is the first to show stimulation of thymidine uptake as well as DNA synthesis under the influence of physiological concentrations of human and chicken GH in fetal chicken osteoblasts in culture.
Slootweg
M C
MC
Department of Internal Medicine, University Hospital Utrecht, The Netherlands.
van Buul-Offers
S C
SC
Herrmann-Erlee
M P
MP
Duursma
S A
SA
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D004247:DNA / Q000096:biosynthesis*; D013006:Growth Hormone / Q000494:pharmacology*; D006801:Humans; D010006:Osteoblasts / Q000378:metabolism*
D013006:Growth Hormone; D004247:DNA