Disseminated blastomycosis in a pregnant woman successfully treated with amphotericin-B. A case report.
An 18-year-old woman developed disseminated blastomycosis in the 30th week of pregnancy. She was treated with amphotericin-B. Simultaneous maternal-infant blood levels at birth were 1.9 and 1.3 micrograms/mL, respectively. The amphotericin-B level in the amniotic fluid was 0.3 microgram/mL at delivery. The infant was normal and without ill effects from either the blastomycosis or the amphotericin-B. The skin lesions and pulmonary infiltrates in the mother improved rapidly, without unexpected side effects from the therapy. The limited experience with amphotericin-B indicates that it is both well tolerated and effective in this clinical situation.
Hager
H
H
Department of Internal Medicine, Quillen-Dishner College of Medicine, Johnson City, Tennessee.
Welt
S I
SI
Cardasis
J P
JP
Alvarez
S
S
D000293:Adolescent; D000666:Amphotericin B / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001759:Blastomycosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*
D000666:Amphotericin B