title: Pressure influences the rate of fibrin polymerization: decompression accelerates, compression decelerates.
abstract: We report here that the rate of fibrin polymerization is accelerated by decompression: the rate is essentially doubled by reducing the pressure by one-half (380 torr, 14.7 PSI or 1/2 ATM) and increased by 3.6 times with respect to the control at 25 torr (0.48 PSI or 1/30th ATM). We also report here that the rate of fibrin polymerization is decelerated by compression; at 5.2 X 10(5) torr (10,000 PSI or 680 ATM) polymerization is inhibited and/or reversed.
authors.affiliation: Laboratory of Physical Biology, NIAMS, Bethesda, Maryland 20892.
authors.forename: M
authors.initials: M
authors.lastname: Murayama
mesh_terms: D000818:Animals; D002417:Cattle; D005337:Fibrin / Q000378:metabolism*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology; D066298:In Vitro Techniques; D010889:Piracetam / Q000494:pharmacology; D011108:Polymers; D011312:Pressure; D014508:Urea / Q000494:pharmacology
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D007093:Imidazoles; D011108:Polymers; D014508:Urea; D005337:Fibrin; D010889:Piracetam