Cross-neutralization tests among Cache Valley virus isolates revealing the existence of multiple subtypes.
Maguari virus has been classified as a subtype of Cache Valley virus. Seven Bunyamwera serogroup viruses (including prototypes Cache Valley and Maguari viruses), 4 viruses shown in previous tests as close antigenic relatives of Maguari or Cache Valley viruses, and Xingu virus were cross-tested by serum dilution-plaque reduction neutralization. All viruses were distinguishable from prototypes Cache Valley and Maguari viruses. The close antigenic relationships of the Cache Valley-like viruses demonstrate that multiple subtypes of Cache Valley virus exist and suggest that such antigenic variation is a phenotypic expression of considerable genetic diversity.
Calisher
C H
CH
Division of Vector-Borne Viral Diseases, U.S. Department of Health and Human Services, Fort Collins, Colorado 80522-2087.
Sabattini
M S
MS
Monath
T P
TP
Wolff
K L
KL
D000956:Antigens, Viral / Q000276:immunology*; D002042:Bunyamwera virus / Q000145:classification* / Q000276:immunology; D002043:Bunyaviridae / Q000145:classification*; D003429:Cross Reactions; D009500:Neutralization Tests; D010948:Viral Plaque Assay
D000956:Antigens, Viral