[Study of the correlation between severity of hypertension and the left ventricular mass and left ventricular functions].
The correlation between the severity of hypertension and the left ventricular mass and left ventricular functions were studied in normal controls (n = 6) and essential hypertensives (n = 37). And we studied the factors that influence on the severity of hypertension by discriminant analysis. Thirty-seven hypertensives were divided into three groups (WHO I 16, WHO II 16, WHO III 5). The left ventricular mass (LVM) was calculated by X-ray computed tomography. The %fractional shortening (%FS), mean Vcf (mVcf) and ejection fraction (EF) were obtained as left ventricular systolic function by echocardiogram. The left ventricular diastolic posterior wall velocity (PWVd) and left ventricular rapid filling volume/stroke volume (RFV/SV) were obtained as left ventricular diastolic function by echocardiogram. The LVMs (g/m2) of controls, WHO I, WHO II and WHO III were 92 +/- 14, 113 +/- 23, 155 +/- 56 and 237 +/- 38. The LVM were great as the stage of hypertension was deteriorated. The left ventricular diastolic function was impaired as hypertension exacerbated. The left ventricular systolic function was not changed in four groups including controls. The LVM was significantly well correlated with systolic blood pressure (r = 0.48, p less than 0.01), diastolic blood pressure (r = 0.30, p less than 0.05), cardiothoracic ratio (r = 0.36, p less than 0.05), SV1 + RV5 on ECG (r = 0.66, p less than 0.001) and left ventricular diastolic function (PWVd; r = 0.49, p less than 0.01, RFV/SV; r = 0.52, p less than 0.001). But, the LVM was poor correlated with left ventricular systolic function. Depending on the discriminant analysis, the LVM and left ventricular diastolic function had significantly well influence on the severity of hypertension and ECG abnormality. As using the LVM calculated by computed tomography, we have exactly and useful informations of essential hypertension.
Kakinoki
S
S
Department of Cardiovascular Medicine, Hokkkido University School of Medicine.
D000328:Adult; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed