[Quantitative parameters of the IgG binding by Fc receptors and the functional activity of blood lymphocytes in healthy cattle and cattle with chronic lympholeukemia].
The binding of IgG to lymphocyte Fc receptors in the blood of healthy cattle and of cattle with chronic lympholeukemia has been studied by fluorometric techniques before and after the incubation of lymphocytes in a serum-free medium at 37 degrees C. The study has shown that changes in the intensity of binding of IgG to Fc receptors of normal and leukemic lymphocytes correlate with changes in the cell-mediated cytotoxic activity of the corresponding lymphocytes. Lower cell-mediated cytotoxic activity of leukemic lymphocytes in comparison with that of normal lymphocytes was parallelled by a lower association constant of IgG with leukemic lymphocytes Fc receptors.
Dikinene
N P
NP
Miliukene
V V
VV
Dedinene
Ia L
IaL
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D001666:Binding Sites, Antibody; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000276:immunology*; D005260:Female; D007074:Immunoglobulin G / Q000032:analysis* / Q000378:metabolism; D007945:Leukemia, Lymphoid / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D008214:Lymphocytes / Q000032:analysis / Q000276:immunology* / Q000378:metabolism; D011961:Receptors, Fc / Q000032:analysis* / Q000378:metabolism; D013050:Spectrometry, Fluorescence
D007074:Immunoglobulin G; D011961:Receptors, Fc
Kolichestvennye parametery sviazyvaniia IgG Fc-retseptorami i funktsional'naia aktivnost' limfotsitov krovi zdorovogo i bol'nogo khronicheskim limfoleĭkozom krupnogo rogatogo skota.