Noradrenergic cerebral stimulation of sensorineural impaired subjects: yohimbine effects on speech intelligibility and the auditory brain response.
Norepinephrine has been shown to improve signal-to-noise ratios of sensory systems, including that of the auditory system. Yohimbine has been observed to cause a selective increase of cerebral norepinephrine. It was administered in one dose to sensorineurally impaired subjects with the object of improving their speech hearing in noise. Speech intelligibility was measured by the adaptive procedure. Mild, significant improvement was noted in one of the hearing components, "attenuation," and an adverse effect was shown on "distortion," owing to noise. Auditory brainstem response was improved significantly. The objective of temporarily improving intelligibility in noise was not attained.
Hughes
E C
EC
Department of Otolaryngology, School of Medicine, University of Southern California, Los Angeles 90033.
Gott
P S
PS
Weinstein
R C
RC
Binggeli
R
R
D000368:Aged; D001300:Audiometry, Evoked Response; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009622:Noise; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology*; D013065:Speech Intelligibility / Q000187:drug effects*; D013069:Speech Reception Threshold Test; D015016:Yohimbine / Q000627:therapeutic use*
D015016:Yohimbine; D009638:Norepinephrine