Isolation and characterization of katanosins A and B.
Two peptide antibiotics katanosins A and B were isolated from the culture broth of a strain related to the genus Cytophaga. These antibiotics are basic peptides soluble in aqueous alcohols. The molecular formulae C57H95N15O17 for A and C58H97N15O17 for B were indicated. The constituent amino acids of katanosin A are suggested to be Thr (1), Ser (1), Val (1), Leu (3), Arg (1) and three unusual amino acids. In katanosin B, the Val residue is replaced by Ile. Katanosins A and B are active against Gram-positive bacteria in vitro and in vivo.
Shoji
J
J
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Hinoo
H
H
Matsumoto
K
K
Hattori
T
T
Yoshida
T
T
Matsuura
S
S
Kondo
E
E
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D003589:Cytophaga / Q000145:classification / Q000378:metabolism; D047630:Depsipeptides; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D010455:Peptides; C056789:katanosin A; C056790:katanosin B