Central nervous system inhibition of pentagastrin-stimulated acid secretion by insulin-like growth factor II.
The ability of intracisternal insulin-like growth factor II (IGF II) to inhibit gastric acid secretion was studied in rats. Centrally-administered IGF II dose-dependently inhibited acid secretion stimulated by pentagastrin. The effect was abolished by vagotomy. IGF II did not inhibit acid secretion stimulated by histamine or PCP-GABA.
Mulholland
M W
MW
Department of Surgery, University of Washington, Seattle 98195.
Debas
H T
HT
D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D002946:Cisterna Magna; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D007267:Injections; D007335:Insulin-Like Growth Factor II / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010418:Pentagastrin / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D012821:Silanes / Q000008:administration & dosage / Q000627:therapeutic use*; D012825:Silicon / Q000627:therapeutic use*; D013002:Somatomedins / Q000494:pharmacology*; D014628:Vagotomy
D012821:Silanes; D013002:Somatomedins; C056320:monomethyltrisilanol; D007335:Insulin-Like Growth Factor II; D006632:Histamine; D010418:Pentagastrin; D001418:Baclofen; D012825:Silicon