Tricyclic antidepressant binding to lymphocyte membranes and changes during depression.
The binding of [3H]imipramine, its 2- and 4-nitroderivatives and [3H]desmethylimipramine to lymphocyte membranes was determined. IC50 values for drugs and neurotransmitters to inhibit [3H]imipramine binding to lymphocyte membranes were comparable with those for brain and thrombocyte membranes. The number of [3H]imipramine and [3H]desmethylimipramine binding sites increased in depressive patients, whereas the dissociation constants remained unchanged.
Krulík
R
R
Psychiatric Research Unit, Faculty of Medicine, Charles University, Prague, Czechoslovakia.
Slíva
D
D
Sikora
J
J
Farská
I
I
Fuksová
K
K
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003866:Depressive Disorder / Q000378:metabolism*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D000929:Antidepressive Agents, Tricyclic