title: Suramin keratopathy.
abstract: Vortex keratopathy occurred in six patients given high-dose intravenous suramin for adrenocortical carcinoma. The corneal findings were bilateral and symmetric. Two patients complained of foreign-body sensation. One patient developed opacities of the anterior lens epithelium. Histopathologic studies of the eyes in one patient showed intraepithelial apical deposits in the cornea, conjunctiva, and lens epithelia. By electron microscopy, these deposits were found to be membranous lamellar inclusion bodies. These findings, as demonstrated by osmium-PAS staining and electron microscopy, were similar to those in other drug-induced lipid storage diseases.
authors.affiliation: Department of Ophthalmology, University of Minnesota, Minneapolis 55455.
authors.forename: E J
authors.initials: EJ
authors.lastname: Holland
authors.forename: C A
authors.initials: CA
authors.lastname: Stein
authors.forename: A G
authors.initials: AG
authors.lastname: Palestine
authors.forename: R
authors.initials: R
authors.lastname: LaRocca
authors.forename: C C
authors.initials: CC
authors.lastname: Chan
authors.forename: T
authors.initials: T
authors.lastname: Kuwabara
authors.forename: C E
authors.initials: CE
authors.lastname: Myers
authors.forename: R
authors.initials: R
authors.lastname: Thomas
authors.forename: N
authors.initials: N
authors.lastname: McAtee
authors.forename: R N
authors.initials: RN
authors.lastname: Nussenblatt
mesh_terms: D000302:Adrenal Cortex; D000310:Adrenal Gland Neoplasms / Q000188:drug therapy; D000328:Adult; D002277:Carcinoma / Q000188:drug therapy; D003316:Corneal Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008027:Light / Q000009:adverse effects; D008297:Male; D010146:Pain; D013498:Suramin / Q000009:adverse effects* / Q000627:therapeutic use; D014792:Visual Acuity
chemical_list: D013498:Suramin