Influence of environmental iodine deficiency on neonatal thyroid screening results.
During a multicentric pilot screening program for congenital hypothyroidism a comparison between the results obtained from Urbino, an area characterized by low iodine supply and endemic goiter, and Rome, a non-endemic area, has been made. The evaluation of neonatal urinary iodine excretion in the two areas showed significantly lower iodine urinary excretion levels in Urbino than in Rome. A shift of TSH at screening toward higher values as well as a higher percentage of recall in Urbino area than in Rome was observed. This finding, which well correlates with a low environmental iodine supply, emphasizes the importance of screening for congenital hypothyroidism as a suitable index of the presence and action of goitrogenic factors in the environment.
Carta Sorcini
M
M
Istituto Superiore di Sanita, Roma, Italy.
Diodato
A
A
Fazzini
C
C
Sabini
G
G
Carta
S
S
Grandolfo
M E
ME
Guidi
M
M
Vasta
M
M
Locatelli De Maestri
J
J
Donati
L
L
D002675:Child, Preschool; D003409:Congenital Hypothyroidism; D004781:Environmental Exposure; D005500:Follow-Up Studies; D006043:Goiter, Endemic / Q000453:epidemiology; D006801:Humans; D007037:Hypothyroidism / Q000378:metabolism; D007231:Infant, Newborn; D007455:Iodine / Q000172:deficiency* / Q000652:urine; D007558:Italy; D008403:Mass Screening / Q000379:methods; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine