title: Bilateral cavernous sinus thrombosis due to mucormycosis.
abstract: A 49-year-old man requiring hemodialysis for end-stage renal disease developed orbital cellulitis and bilateral central retinal artery occlusions. Although cranial computed tomography demonstrated ethmoid and sphenoid sinusitis, two surgical biopsy specimens of sinus mucosa were nondiagnostic. Autopsy findings confirmed cerebral mucormycosis with bilateral cavernous sinus and carotid artery thrombosis. The patient had been taking deferoxamine for hemochromatosis, and this chelating agent may have been the predisposing factor in developing mucormycosis. We discuss the limitations of current neuroimaging techniques in establishing the diagnosis of both cerebral mucormycosis and cavernous sinus thrombosis.
authors.affiliation: Combined Program in Ophthalmology, Eye Foundation Hospital, Birmingham, AL.
authors.forename: E
authors.initials: E
authors.lastname: Van Johnson
authors.forename: L B
authors.initials: LB
authors.lastname: Kline
authors.forename: B A
authors.initials: BA
authors.lastname: Julian
authors.forename: J H
authors.initials: JH
authors.lastname: Garcia
mesh_terms: D001927:Brain Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D002341:Carotid Artery Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D003392:Cranial Sinuses / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D012851:Sinus Thrombosis, Intracranial / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D012852:Sinusitis / Q000150:complications / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed