Acute tolerance to cocaine in humans.
There is controversy as to whether acute tolerance develops to the principal effects of cocaine in humans. The studies described here demonstrate the phenomenon of acute tolerance to cocaine chronotropic and subjective effects and the rate and extent of tolerance development. Stable plasma cocaine concentrations were produced and then maintained in volunteer cocaine users by administering an intravenous cocaine injection followed by a cocaine infusion designed to compensate for the plasma clearance of cocaine. The euphoric effect (high) intensified to a peak at about 1 hour and then declined toward baseline at 4 hours despite the presence of constant plasma cocaine levels. The chronotropic effect reached a peak within 10 minutes and then declined, with a half-life of 31 +/- 13 (mean +/- SD) minutes toward a plateau at 33% +/- 21% of its peak intensity. Tolerance development was quantified as an exponential process, with a rate constant (tolerance factor) accounting for the progressive alteration of the cocaine concentration-effect relationship.
Ambre
J J
JJ
Department of Medicine, Northwestern University Medical School, Chicago, IL.
Belknap
S M
SM
Nelson
J
J
Ruo
T I
TI
Shin
S G
SG
Atkinson
A J
AJ
D000328:Adult; D003042:Cocaine / Q000097:blood / Q000493:pharmacokinetics*; D004361:Drug Tolerance; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008954:Models, Biological
D003042:Cocaine