title: PGE1 reduces collagen and glycosaminoglycan synthesis in rabbit aorta.
abstract: In 18 male rabbits the influence of PGE1 on collagen and glycosaminoglycan synthesis assessed by means of the incorporation of radiolabelled precursors has been examined. It is demonstrated that PGE1 induces a 20-30% drop both in 14C-proline and 35S incorporation into the vessel wall. These findings are in line with earlier data on the inhibition of proliferation of smooth muscle cells and a decrease in mitotic activity. The results present one piece of evidence more that PGE1 is acting as an anti-atherosclerotic agent in vivo at the vascular level. This pathomechanism, as well as the fact that this vascular effect is achieved--in an animal experiment at least--via an intravenous PGE1-application, offers new basics for the treatment of atherosclerosis in man.
authors.affiliation: Atherosclerosis Research Group Vienna (ASF), Austrian Academy of Sciences.
authors.forename: H
authors.initials: H
authors.lastname: Sinzinger
authors.forename: T
authors.initials: T
authors.lastname: Zidek
authors.forename: W
authors.initials: W
authors.lastname: Rogatti
mesh_terms: D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis*; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D008297:Male; D011392:Proline / Q000378:metabolism; D011817:Rabbits; D013455:Sulfur / Q000378:metabolism
chemical_list: D006025:Glycosaminoglycans; D013455:Sulfur; D003094:Collagen; D011392:Proline; D000527:Alprostadil