On the in vitro cytotoxicity of 1-chloroethyl-2-chloromethyl-2-imidazoline hydrochloride.
The cytotoxic activity of the monofunctional alkylating agent 1-chloroethyl-2-chloromethyl-2-imidazoline hydrochloride (chlorimidazine), synthesized according to predetermined properties, is characterized. The data obtained show that the substance has a cell-cycle state nonspecific cytotoxic effect. The interaction of chlorimidazine with cellular DNA is traced. It is found that the substance does not induce a break in the macromolecule, apurine sites or intercalation. Ensuing from the chemical structure of the compound, the probable mechanism of its cytotoxic action is discussed.
Mircheva
J J
JJ
Laboratory of Experimental Tumour Therapy, Medical Academy, Sofia.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology*; D009691:Nucleic Acid Denaturation; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D007093:Imidazoles; C047705:chlorimidazine