title: Formation of double minutes by breakdown of a homogeneously staining region in a refractory anemia with excess blasts.
abstract: A patient suffering from refractory anemia with excess blasts in transformation had four different bone marrow karyotypes. These were 46,XY; 45,X,-Y; 45,X,-Y, 5q-,19q+; and 43,X,-Y,-9,-17,5q-,+dmin. The most plausible explanation for this is proposed to be formation of a homogeneously staining region on chromosome #19, followed by its breakdown into double minutes.
authors.affiliation: Cytogenetics Department, N. J. Nicolaides & Partners, Brisbane, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Brookwell
authors.forename: F A
authors.initials: FA
authors.lastname: Hunt
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood / Q000235:genetics* / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D006801:Humans; D007621:Karyotyping; D008297:Male