title: Measurement of trazodone using solid-phase extraction and wide-bore capillary gas chromatography with nitrogen-selective detection.
abstract: A method for the determination of the antidepressant drug trazodone is presented. 8-Hydroxyloxapine is used as the internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C18 columns is described. Samples are analyzed by gas chromatography with nitrogen-selective detection using a wide-bore capillary column with a permanently bonded, nonpolar stationary phase. The assay possesses linearity to 3.0 micrograms/mL, sensitivity to at least 0.25 microgram/mL, recovery averaging 96%, and between-run precision reflected by a CV of 5.6%. We conclude that the method reported here is ideally suited for monitoring therapeutic and toxic levels of trazodone.
authors.affiliation: Department of Pathology, University of North Carolina School of Medicine, Chapel Hill 27514.
authors.forename: N
authors.initials: N
authors.lastname: Rifai
authors.forename: C B
authors.initials: CB
authors.lastname: Levtzow
authors.forename: C M
authors.initials: CM
authors.lastname: Howlett
authors.forename: J C
authors.initials: JC
authors.lastname: Phillips
authors.forename: N C
authors.initials: NC
authors.lastname: Parker
authors.forename: R E
authors.initials: RE
authors.lastname: Cross
mesh_terms: D002849:Chromatography, Gas / Q000295:instrumentation; D014196:Trazodone / Q000032:analysis*
chemical_list: D014196:Trazodone