title: Prognostic influence of ploidy level and histopathologic differentiation in cervical carcinoma stage Ib.
abstract: Flow-cytometric DNA analysis and extended histopathologic grading were performed in specimens from 126 patients with squamous cell carcinoma of the uterine cervix stage Ib. Archival material was used for the measurements and the ploidy level was analysed according to the method described by Hedley with some modifications. The histopathologic grading was based on eight well-defined parameters all scored 1-3. The results showed that the ploidy level held significant prognostic information about the 10 year survival according to a division of DNA indices above and below 1.5. Further prognostic information appeared from a combination of DNA index and histopathologic score value. The combination held its prognostic importance in subgroups of patients with different tumour sizes. It is concluded that flow-cytometric analysis and histopathologic grading can identify subsets of patients who need more aggressive treatment.
authors.affiliation: Department of Oncology, Aarhus University Hospital, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Jakobsen
authors.forename: P
authors.initials: P
authors.lastname: Bichel
authors.forename: G B
authors.initials: GB
authors.lastname: Kristensen
authors.forename: M
authors.initials: M
authors.lastname: Nyland
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000032:analysis / Q000401:mortality / Q000473:pathology; D002454:Cell Differentiation; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D011003:Ploidies; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000032:analysis / Q000401:mortality / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm