title: [Reaction of deamination of monoamines in the brain and heart of rats under the toxic action of hyperbaric oxygenation].
abstract: Kinetic parameters of monoamine deamination processes in the rat brain and heart after hyperbaric oxygenation (HBO) in toxic conditions (6 ata) were studied. HBO was shown to cause a substantial reduction in MAO affinity to serotonin in the brain, but not in the heart. Contrastingly, MAO affinity to dopamine was found to decrease in the heart, but not in the brain in response to HBO. Differences of tyramine and 2-phenylethylamine deamination in the rat brain and heart were also reciprocal following toxic HBO. In the initial phase of seizure episode MAO activity in the brain and heart was also different. Distinct mechanisms of adaptation to toxic oxygen in the central nervous system and cardiovascular system are discussed.
authors.forename: E M
authors.initials: EM
authors.lastname: Gankina
authors.forename: O A
authors.initials: OA
authors.lastname: Gol'dina
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Shamakina
authors.forename: E A
authors.initials: EA
authors.lastname: Demurov
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Koloskov
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology*; D003641:Deamination; D004298:Dopamine; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology*; D010627:Phenethylamines; D051381:Rats; D012701:Serotonin; D014439:Tyramine
chemical_list: D010627:Phenethylamines; C029261:phenethylamine; D012701:Serotonin; D008995:Monoamine Oxidase; D004298:Dopamine; D014439:Tyramine
vernacular_title: Reaktsiia dezaminirovaniia monoaminov v mozge i serdtse krys pri toksicheskom deĭstvii giperbaricheskoĭ oksigenatsii.