title: Effects of xylazine and acepromazine on bronchomotor tone of anaesthetised ponies.
abstract: The effects of xylazine (an alpha 2-adrenoceptor agonist) and acepromazine (an alpha-adrenoceptor antagonist) on bronchomotor tone were investigated in seven anaesthetised, apnoeic ponies using a computer aided forced oscillation technique, which separates changes in bronchial calibre from changes in lung volume. Both agents produced bronchodilatation and a decrease in lung volume.
authors.affiliation: University of Cambridge, Department of Clinical Veterinary Medicine.
authors.forename: G C
authors.initials: GC
authors.lastname: Watney
authors.forename: L W
authors.initials: LW
authors.lastname: Hall
authors.forename: C
authors.initials: C
authors.lastname: Jordan
authors.forename: A M
authors.initials: AM
authors.lastname: Nolan
mesh_terms: D000075:Acepromazine / Q000494:pharmacology*; D000818:Animals; D001980:Bronchi / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006736:Horses / Q000502:physiology*; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000494:pharmacology*
chemical_list: D013843:Thiazines; D014991:Xylazine; D000075:Acepromazine