Pharmacokinetics of diltiazem in patients undergoing continuous ambulatory peritoneal dialysis.
The disposition of a single oral dose of diltiazem hydrochloride was studied in six male patients treated by continuous ambulatory peritoneal dialysis. Peak concentrations were obtained 2 to 4 hours postdose. The mean absorption rate constant was 0.94 +/- 0.21 (sd) hr-1, and the mean elimination half-life was 3.09 +/- 1.16 hr. Serum levels of deacetyldiltiazem, a metabolite of diltiazem, were always below 10 ng/mL. The amounts of diltiazem and deacetyldiltiazem eliminated in dialysate over 24 hours represent less than 0.1% of the administered dose. The pharmacokinetic parameters of diltiazem determined in these patients did not differ from those determined in healthy volunteers and in patients suffering from end-stage renal disease.
Grech-Bélanger
O
O
School of Pharmacy, Laval University, Ste-Foy, Quebec, Canada.
Langlois
S
S
LeBoeuf
E
E
D000328:Adult; D004110:Diltiazem / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory
D004110:Diltiazem