Application of electron microscopy to human otopathology. Ultrastructural findings in neural presbycusis, Menière's disease and Usher's syndrome.
Electron microscopy of well-preserved postmortem specimens of the inner ear of the human can provide significant details concerning human otopathology not discernible by light microscopy. As examples, ultrastructural findings in neural presbycusis, Meniere's disease and Usher's syndrome are presented. In all three pathologies there is evidence of neuronal degeneration, particularly within the dendritic arborization of the spiral ganglion, which is not observable by light microscopy.
Nadol
J B
JB
Department of Otology and Laryngology, Harvard Medical School, Boston, Mass.
D000368:Aged; D000369:Aged, 80 and over; D007758:Ear, Inner / Q000648:ultrastructure*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000473:pathology*; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D009410:Nerve Degeneration; D011304:Presbycusis / Q000473:pathology*; D012174:Retinitis Pigmentosa / Q000473:pathology*; D013136:Spiral Ganglion / Q000648:ultrastructure; D013577:Syndrome