Improved intestinal cannula for drug delivery studies in the dog.
A modified light-weight intestinal cannula, based on the modified Thomas type (Thomas, 1941; Jones et al., 1971) was fabricated and tested. The design extends the useful life of the cannula and expands the versatility of the canine gastrointestinal (GI) system for pharmaceutical and physiological research. The cannula permits easy administration of pharmaceutical dosage forms directly into or access to ingested substances anywhere along the small intestine.
Rubinstein
A
A
School of Pharmacy, University of Wisconsin, Madison 53706.
Li
V H
VH
Gruber
P
P
Bass
P
P
Robinson
J R
JR
D000818:Animals; D002404:Catheterization / Q000295:instrumentation* / Q000379:methods; D002408:Catheters, Indwelling; D004285:Dogs; D004333:Drug Administration Routes; D004386:Duodenum; D007082:Ileum