Alprazolam dependency: use of clonazepam for withdrawal.
Ten alprazolam-dependent patients were studied with clinical and biologic variables after equal doses of clonazepam were substituted for alprazolam. Withdrawal was accomplished over a seven-day period. Anxiety and plasma cortisol levels were measured and found not to be significantly different between the withdrawal period and the postwithdrawal medication-free period.
Patterson
J F
JF
Psychiatry Service, Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65201.
D000328:Adult; D000525:Alprazolam / Q000009:adverse effects* / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000175:diagnosis / Q000188:drug therapy; D002998:Clonazepam / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000188:drug therapy*
D002998:Clonazepam; D006854:Hydrocortisone; D000525:Alprazolam