title: [Clinical pharmacology of the new Soviet anti-inflammatory preparation ortofen].
abstract: Comparative pharmacokinetic and pharmacodynamic studies on ortophen, a new Soviet antiinflammatory drug, and voltaren (Ciba-Geigy, Switzerland) were carried out in 73 patients with rheumatoid arthritis. Pharmacokinetics of both drugs was studied in 19 patients (9 patients were given voltaren, 10--ortophen). Pharmacokinetic difference was statistically indistinguishable. The comparison of the principal routine subjective and objective pharmacodynamic indices revealed no significant difference between ortophen and voltaren action. The new drug was shown to possess a high analgetic and antiinflammatory activity.
authors.forename: V G
authors.initials: VG
authors.lastname: Kukes
authors.forename: V V
authors.initials: VV
authors.lastname: Murashko
authors.forename: M V
authors.initials: MV
authors.lastname: Iagunina
authors.forename: V I
authors.initials: VI
authors.lastname: Volchenok
authors.forename: V I
authors.initials: VI
authors.lastname: Pokryshkin
mesh_terms: D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy; D001799:Blood Sedimentation; D004008:Diclofenac / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D004341:Drug Evaluation; D004361:Drug Tolerance; D006207:Half-Life; D006801:Humans; D013997:Time Factors
chemical_list: D004008:Diclofenac
vernacular_title: Klinicheskaia farmakologiia novogo otechesvennogo protivovospalitel'nogo preparata ortofena.