title: Phase II evaluation of teniposide (VM-26) in metastatic breast carcinoma. A Southeastern Cancer Study Group trial.
abstract: The Southeastern Cancer Study Group performed a Phase II study of teniposide in previously treated patients with metastatic breast cancer. No responses were observed in 11 evaluable patients who received teniposide 60 mg/m2 by IV infusion for five consecutive days every three weeks. Toxicity was primarily gastrointestinal and hematologic and was frequently severe. This study demonstrated no therapeutic activity for teniposide when given in this dose and schedule to patients with heavily pretreated metastatic breast cancer.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC.
authors.forename: E B
authors.initials: EB
authors.lastname: Cox
authors.forename: C L
authors.initials: CL
authors.lastname: Vogel
authors.forename: J T
authors.initials: JT
authors.lastname: Carpenter
authors.forename: M
authors.initials: M
authors.lastname: Raney
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004341:Drug Evaluation; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011034:Podophyllotoxin / Q000031:analogs & derivatives*; D013713:Teniposide / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D013713:Teniposide; D011034:Podophyllotoxin