[Specific antitumor cytotoxicity of blood platelets from the peripheral blood of patients with lung cancer].
The analysis of cytotoxic activity of platelets from patients with lung cancer is presented. It has been shown that these platelets lyse fresh isolated autological and allogenic tumor cells in 38.5% of cases and lyse the cells in the culture of lung adenocarcinoma cell line in 82.4% of cases, while platelets from healthy donors do not lyse fresh isolated and cultured cells of lung cancer. Cytotoxicity of platelets from patients and control subjects against HeLa and K 562 was identical and did not exceed 10%. The platelets from healthy controls, unlike platelets from patients with lung cancer, lysed tumor cells of melanoma cultured cell line Mel 1. Thus, it has been shown for the first time that platelets from the peripheral blood of patients with lung cancer have specific antitumor activity.
Bykovskaia
S N
SN
Blokhina
N G
NG
Speranskiĭ
D L
DL
Kuprianova
T A
TA
D000230:Adenocarcinoma / Q000097:blood / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology*; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic; D006367:HeLa Cells; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000276:immunology*; D008545:Melanoma / Q000276:immunology
Spetsificheskaia protivoopukholevaia tsitotoksichnost' trombotsitov perifericheskoĭ krovi bol'nykh rakom legkogo.