[Effect of uterine contraction stimulants on active and passive transport of Ca2+ in the fraction of myometrium sarcolemma].
Effect of drugs (quinine, sigetine, isoverine and pachycarpine) stimulating uterine contraction on active and passive Ca2+ transport was studied in cow myometrium sarcolemma. Isoverine and pachycarpine at concentrations 10(-6)-10(-2) M did not affect the systems of Ca2+ transport. Quinine at concentrations above 10(-3) M decreased the rate of Mg2+ ATP-dependent accumulation of Ca2+ and stimulated passive elimination of the cation from vesicles due to an increase in unspecific permeability of myometrial sarcolemma. Sigetine (10(-6) = 10(-2) M) did not affect the Ca2+ passive transport but inhibited uncompetitively the Mg2+ ATP-dependent accumulation of Ca2+ in sarcolemmal vesicles. Effect of sigetine as a stimulator of the uterine contractile activity is apparently based on inhibition of the calcium pump in plasmatic membrane of myometrial cells.
Kurskiĭ
M D
MD
Shinlova
O P
OP
Fomin
V P
VP
Kosterin
S A
SA
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002417:Cattle; D005260:Female; D066298:In Vitro Techniques; D009215:Myometrium / Q000378:metabolism*; D012508:Sarcolemma / Q000378:metabolism*; D014590:Uterine Contraction / Q000187:drug effects*
D002118:Calcium
Vliianie stimuliatorov sokrashcheniia matki na aktivnyĭ i passivnyĭ transport Ca2+ vo fraktsii sarkolemmy miometriia.