title: Composite glandular-carcinoid tumors of the colon and rectum. Report of two cases.
abstract: Composite glandular-carcinoid tumors of the large bowel are rare. We describe two cases that appeared to be at a relatively early stage in their development. Each of these cases was a composite colorectal adenoma-carcinoid--an entity that has not previously been described. There was no evidence of inflammatory bowel disease (IBD) in either of these cases; and a review of the literature on composite adenocarcinoma-carcinoid neoplasms of the colon and rectum revealed only two cases that arose in a background of IBD. Thus, despite the association of IBD, especially long-standing ulcerative colitis, with epithelial dysplasia and mucosal endocrine cell hyperplasia, respectively, we believe that other factors more significant than IBD may be operative in the genesis of composite glandular-carcinoid tumors of the large bowel. Further documentation of these tumors is needed in order to better appreciate their clinicopathologic manifestations and associations.
authors.affiliation: Department of Pathology, University Hospital, Saskatoon, Saskatchewan, Canada.
authors.forename: T N
authors.initials: TN
authors.lastname: Moyana
authors.forename: A H
authors.initials: AH
authors.lastname: Qizilbash
authors.forename: F
authors.initials: F
authors.lastname: Murphy
mesh_terms: D000236:Adenoma / Q000601:surgery / Q000648:ultrastructure*; D000368:Aged; D002276:Carcinoid Tumor / Q000601:surgery / Q000648:ultrastructure*; D003111:Colonic Polyps / Q000601:surgery / Q000648:ultrastructure*; D005260:Female; D006801:Humans