Monoclonal antibodies to intermediate filament proteins: diagnostic specificity in orbital pathology.
Intermediate filaments derived from different cell types are antigenically distinct. Monoclonal antibodies to human intermediate filament proteins can, therefore, be used as tissue-specific reagents capable of distinguishing cell type in poorly differentiated neoplasms. We report a case demonstrating the specificity of antiintermediate filament protein antibodies in establishing a difficult orbital diagnosis of esthesioneuroblastoma.
Lindquist
T D
TD
Department of Ophthalmology, University of Washington School of Medicine, Seattle.
Orcutt
J C
JC
Gown
A M
AM
D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D001706:Biopsy; D002648:Child; D005260:Female; D006801:Humans; D007381:Intermediate Filament Proteins / Q000276:immunology*; D008198:Lymph Nodes / Q000473:pathology; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed
D000911:Antibodies, Monoclonal; D007381:Intermediate Filament Proteins