Enzymatic and hormonal responses following a 24 h endurance run and a 10 h triathlon race.
Muscle cell leakage and hormonal changes were compared immediately after and during the 3 days following a 24 h endurance run (R24h) in 8 subjects, and a 10 h triathlon non-competitive race (T10h) in 6 subjects. The study showed three main differences: 1) plasma enzyme increases were considerably more significant in R24h than in T10h: compared with resting levels, creatine kinase increased x 120 after R24h but only x 2 after T10h; lactic dehydrogenase x 4, as opposed to x 1.5; and transaminases only showed an increase after R24h. The plasma myoglobin increase after R24h was double that found after T10h; 2) for the same magnitude of plasma aldosterone and cortisol after R24h and T10h (3 times the resting levels), a highly significant decrease in urinary Na+ (p less than 0.001) and an increase in urinary K+ (p less than 0.01) were found only after R24h; and 3) the plasma free noradrenaline level increased significantly after R24h (x 2.6) whereas it was unchanged after T10h. In contrast, the plasma level of conjugated dopamine increased only after T10h (x 3.7, p less than 0.05). These results suggest that long-distance running causes more muscular lesions than the triathlon, and that important factors other than aldosterone are probably involved in the regulation of urinary electrolyte excretions during T10h.
Fellmann
N
N
Laboratoire de Physiologie, Faculté de Médecine, Clermont-Ferrand, France.
Sagnol
M
M
Bedu
M
M
Falgairette
G
G
Van Praagh
E
E
Gaillard
G
G
Jouanel
P
P
Coudert
J
J
D000328:Adult; D000450:Aldosterone / Q000097:blood; D001642:Bicycling; D001835:Body Weight; D002395:Catecholamines / Q000097:blood*; D003404:Creatinine / Q000652:urine; D004798:Enzymes / Q000097:blood*; D005260:Female; D006439:Hemodynamics; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D011188:Potassium / Q000097:blood; D012420:Running; D012964:Sodium / Q000097:blood; D013550:Swimming
D002395:Catecholamines; D004798:Enzymes; D006728:Hormones; D000450:Aldosterone; D012964:Sodium; D003404:Creatinine; D011188:Potassium; D006854:Hydrocortisone