[Effect of vitamin E on the energy allowance of functional and plastic processes in the myocardium during ischemia and reoxygenation].
It was found that preliminary (before ischemia) administration of vitamin E in a dose of 200 mg/kg to albino rats causes the changes in energy support of the ischemic myocardium leading to prolonged maintenance of synthesis processes: energy production, cGMP concentration, unsaturation of cell membrane lipids increase. The combination of all these factors probably determines the anti-ischemic effect of vitamin E providing adequate restoration of the myocardial function in the postischemic period.
Artamonov
S D
SD
Danilov
M A
MA
Kirpatovskiĭ
V I
VI
Burdina
G V
GV
Onishchenko
N A
NA
D000818:Animals; D003327:Coronary Disease / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D010100:Oxygen / Q000008:administration & dosage*; D010477:Perfusion; D051381:Rats; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E; D010100:Oxygen
Vliianie vitamina E na énergeticheskoe obespechenie funktsional'nykh i plasticheskikh protsessov v miokarde pri ishemii i reoksigenatsii.