Evaluation of proliferative activity in human head and neck tumors using the monoclonal antibody Ki-67.
The monoclonal antibody Ki-67 is directed against a human nuclear antigen occurring in proliferating cells. As a rule it is absent in quiescent cells. Seven cases of squamous cell carcinomas with different pathohistological features are investigated by immunostaining. The antibody Ki-67 is suitable for use as a marker for proliferative compartments of head and neck tumors. Squamous cell carcinomas show a correlation between Ki-67 labeling index and histological differentiation. In highly differentiated parts of the carcinomas, an additional granular immunostaining in the entire cytoplasm of some squamous epithelial cells was observed.
Lörz
M
M
Klinikum der J.W. Goethe-Universität, Zentrum der Hals-Nasen-Ohrenheilkunde, Frankfurt a. M., BRD.
Meyer-Breiting
E
E
D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002455:Cell Division; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry
D000911:Antibodies, Monoclonal