Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples.
Statistical tests of carcinogenicity are shown to have varying degrees of robustness to the effects of mortality. Mortality induced by two different mechanisms is studied--mortality due to the tumor of interest, and mortality due to treatment independent of the tumor. The two most commonly used tests, the life-table test and the Cochran-Armitage linear trend test, are seen to be highly sensitive to increases in treatment lethality using small-sample simulations. Increases in tumor lethality are seen to affect the performance of commonly used prevalence tests such as logistic regression. A simple survival-adjusted quantal response test appears to be the most robust of all the procedures considered.
Bailer
A J
AJ
Division of Biometry and Risk Assessment, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Portier
C J
CJ
D000818:Animals; D001699:Biometry / Q000379:methods*; D008962:Models, Theoretical; D009152:Mutagenicity Tests / Q000379:methods*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000401:mortality* / Q000628:therapy; D013269:Stochastic Processes