Growth of normal and neoplastic rat pleural mesothelial cells in the presence of conditioned medium from neoplastic mesothelial cells.
Several transformed cells have been demonstrated to secrete growth factors. We studied the effect of conditioned medium from neoplastic rat pleural mesothelial cells on normal and neoplastic mesothelial cell growth. The results showed that the concentrated conditioned medium stimulated neoplastic mesothelial cell growth but inhibited reversibly normal mesothelial cell growth.
Van der Meeren
A
A
Equipe Pathologie Cellulaire de l'Environnement, INSERM U 139, CHU Henri Mondor, Créteil, France.
Levy
F
F
Bignon
J
J
Jaurand
M C
MC
D000818:Animals; D002448:Cell Adhesion; D002455:Cell Division; D003470:Culture Media; D006133:Growth Substances / Q000096:biosynthesis*; D008654:Mesothelioma / Q000473:pathology*; D010994:Pleura / Q000166:cytology*; D010997:Pleural Neoplasms / Q000473:pathology*; D051381:Rats; D014407:Tumor Cells, Cultured
D003470:Culture Media; D006133:Growth Substances