Biomonitoring of aromatic amines and alkylating agents by measuring hemoglobin adducts.
Analysis of hemoglobin adducts in blood samples is suitable for the biological monitoring of genotoxic chemicals. The method is specific because the compound to which the individual was exposed is identified. The sensitivity of the method depends on the analytical procedure applied, but is hardly limiting since large amounts of the protein can be obtained. The method provides not only information about the internal exposure to the environmental chemical, but also about the individual's capacity to generate ultimate genotoxic metabolites from it. Since macromolecular damage in blood cells is correlated to that in potential target tissues, this information is relevant to risk assessment, insofar as macromolecular damage produced by a specific chemical can be correlated with the development of tumors.
Neumann
H G
HG
Institute of Pharmacology and Toxicology, University of Würzburg, Federal Republic of Germany.
D000477:Alkylating Agents / Q000493:pharmacokinetics*; D000588:Amines / Q000493:pharmacokinetics*; D000818:Animals; D004247:DNA / Q000378:metabolism; D004781:Environmental Exposure; D004912:Erythrocytes / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D051381:Rats
D000477:Alkylating Agents; D000588:Amines; D006454:Hemoglobins; D004247:DNA