Biological activities of lipid A from Vibrio parahaemolyticus: stimulation of murine peritoneal macrophages.
The toxicity and macrophage stimulating property of Vibrio parahaemolyticus lipid A was studied. The LD50 dose of lipid A in galactosamine-sensitized mice was found to be 0.6 micrograms when injected intraperitoneally. Administration of lipid A resulted in stimulation of peritoneal macrophages as evident by increase in their cellular RNA contents and lysosomal enzyme activities. The treatment also caused enhancement in the phagocytic activity of macrophages.
Bandekar
J R
JR
Food Technology and Enzyme Engineering Division, Bhabha Atomic Research Centre, Trombay, Bombay, India.
Nerkar
D P
DP
D000818:Animals; D005688:Galactosamine / Q000494:pharmacology; D008050:Lipid A / Q000276:immunology* / Q000302:isolation & purification / Q000633:toxicity; D008262:Macrophage Activation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D014736:Vibrio parahaemolyticus / Q000276:immunology*
D008050:Lipid A; D005688:Galactosamine