title: Toxicokinetics of paraquat through the heart-lung block. Six cases of acute human poisoning.
abstract: A technique is described in which the toxicokinetics of paraquat on passage through the heart and lung were studied by means of blood samples drawn simultaneously from the pulmonary and radial arteries in six cases of acute human life-threatening paraquat intoxications. There was a trend for the radial plasma concentrations of paraquat to be greater than or equal to the pulmonary concentrations. This data suggests that from a clinical point of view the distribution of paraquat into the lungs is not a slow process. There may also exist some efflux of the paraquat into the circulation. This efflux of paraquat may result from direct lung and/or heart injury induced by massive paraquat poisoning.
authors.affiliation: Clinique et Laboratoire de Toxicologie, Hopital Fernand Widal, Universites Paris 5 et 7, INSERM U26, France.
authors.forename: F J
authors.initials: FJ
authors.lastname: Baud
authors.forename: P
authors.initials: P
authors.lastname: Houze
authors.forename: C
authors.initials: C
authors.lastname: Bismuth
authors.forename: J M
authors.initials: JM
authors.lastname: Scherrmann
authors.forename: A
authors.initials: A
authors.lastname: Jaeger
authors.forename: C
authors.initials: C
authors.lastname: Keyes
mesh_terms: D000328:Adult; D000368:Aged; D003331:Coronary Vessels; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D010269:Paraquat / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D011651:Pulmonary Artery; D013406:Suicide, Attempted
chemical_list: D010269:Paraquat