title: [[Neoadjuvant chemotherapy (cisplatin, doxorubicin, cyclophosphamide) in the treatment of invasive urothelial tumors of the bladder. Preliminary results of a prospective study concerning 22 patients].
abstract: Twenty two patients with transitional cell bladder carcinoma (T greater than or equal to 2 Mo) received 2 or 3 courses of systemic chemotherapy (cyclophosphamide 600 mg/m2, doxorubicin 60 mg/m2, cisplatinum 100 mg/m2) prior to total (18) or partial (18) cystectomy. Response rate was appreciated on the pathologic findings of the surgically removed bladders (pTNM): 5 tumor progression (23%); 8 tumor stability (36%); 3 partial remission (14%); 4 complete remission (18%), 2 pTo after complete transurethral resection (9%). These results lead us to conclude that: the rate of tumor progression and stability was too high. Further experience will require a more effective preoperative treatment; clinical staging dramatically underestimates tumor spread; prognosis of non responders is quite poor: 7 deaths with a maximum follow-up of 6 months.
authors.affiliation: Service d'Urologie B, Hôpital Necker, Paris.
authors.forename: F
authors.initials: F
authors.lastname: Trifard
authors.forename: Y
authors.initials: Y
authors.lastname: Chrétien
authors.forename: X
authors.initials: X
authors.lastname: Vallantin
authors.forename: C
authors.initials: C
authors.lastname: Collet
authors.forename: A T
authors.initials: AT
authors.lastname: Lachand
authors.forename: B
authors.initials: B
authors.lastname: Dufour
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011379:Prognosis; D011446:Prospective Studies; D001743:Urinary Bladder / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin
vernacular_title: Chimiothérapie néoadjuvante (cisplatine, doxorubicine, cyclophosphamide) dans le traitement des tumeurs urothéliales infiltrantes de vessie. Résultats préliminaires d'une étude prospective portant sur vingt-deux patients.