Adult chronic granulomatosis disease-like neutrophil granulocyte disorder corrected by dialysable leukocyte extract.
A 47 year old female presented with a septic clinical picture including fever, abscesses, late cachexia, and unmanageable by disease. Similar characteristics to chronic granulomatosis disease (CGD) seriously decreased intracellular killing activity and chemiluminescence, granulomas in the histology, and the role of genetic factors were found, suggesting that our case is CGD-like disorder, manifested in an adult. Dialysable leukocyte extract (DLE) therapy, complemented with fresh normal plasma, resulted in a striking clinical improvement and there was an increase in the in vitro PMNL intracellular killing activity, too. Although it is generally accepted that DLE derives from monocytes and lymphocytes, it is possible that DLE is a family of DNA-oligopeptide molecules, including factors derived from PMNLs which are capable of influencing PMNL function, transferring information from normal cells. Our results also suggest that it would be worth trying DLE in patients with classic CGD.
Lukács
K
K
3rd Department of Medicine, University Medical School, Debrechen, Hungary.
Szabó
G
G
Schröder
I
I
Szegedi
G
G
D000038:Abscess / Q000209:etiology; D002634:Chemotaxis, Leukocyte; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000032:analysis; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology / Q000473:pathology*; D010585:Phagocyte Bactericidal Dysfunction / Q000150:complications / Q000628:therapy*; D010587:Phagocytosis; D012397:Rosette Formation; D014165:Transfer Factor / Q000302:isolation & purification / Q000627:therapeutic use*
D014165:Transfer Factor