title: A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs.
abstract: The CTF/NF-I group of cellular DNA binding proteins recognizes the sequence GCCAAT and is implicated in eukaryotic transcription as well as DNA replication. Molecular analysis of human CTF/NF-I complementary DNA clones reveals multiple messenger RNA species containing alternative coding regions, apparently as a result of differential splicing. Expression and functional analysis establish that individual gene products can bind to GCCAAT recognition sites and serve both as promoter-selective transcriptional activators and as initiation factors for DNA replication.
authors.affiliation: Howard Hughes Medical Institute, Department of Biochemistry, University of California, Berkeley.
authors.forename: C
authors.initials: C
authors.lastname: Santoro
authors.forename: N
authors.initials: N
authors.lastname: Mermod
authors.forename: P C
authors.initials: PC
authors.lastname: Andrews
authors.forename: R
authors.initials: R
authors.lastname: Tjian
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000378:metabolism; D012326:RNA Splicing; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic; D014779:Virus Replication
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors; D004247:DNA; D012319:RNA Polymerase II