Influence of hypertension and antihypertensive drugs on the biological intra-individual variation of electrolytes and lipids in serum.
Biological intra-individual CVs for Na+, Cl-, K+, calcium, cholesterol, high-density lipoprotein cholesterol, triglycerides in serum, and hemoglobin in blood were estimated in men with essential hypertension (EH) treated with beta-blockers and diuretics, and compared with those of normotensive men. Although in EH the mean concentrations of Na+, Cl-, K+, hemoglobin, and triglycerides were increased and that of HDL cholesterol was decreased, the average intra-individual CVs did not significantly differ between the two groups. The mean concentration of cholesterol, as well as the average intra-individual CV for it, was significantly higher in EH. There was no correlation between the intra-individual CVs for the analytes and the mean blood pressure of the individuals. Individual values were normally distributed for all analytes. There was no increase of the intra-individual CV with the lapse of time between consecutively measured values. The estimated average biological intra-individual CV was used to derive decision-making criteria for interpretation of test results observed in monitoring EH.
Hölzel
W G
WG
Institute of Pathological and Clinical Biochemistry, Charite Hospital, Humboldt University, Berlin, G.D.R.
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood; D002712:Chlorides / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004573:Electrolytes / Q000097:blood*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D014280:Triglycerides / Q000097:blood
D000959:Antihypertensive Agents; D002712:Chlorides; D008076:Cholesterol, HDL; D004573:Electrolytes; D006454:Hemoglobins; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D012964:Sodium; D011188:Potassium; D002118:Calcium