title: Influence of environmental iodine deficiency on neonatal thyroid screening results.
abstract: During a multicentric pilot screening program for congenital hypothyroidism a comparison between the results obtained from Urbino, an area characterized by low iodine supply and endemic goiter, and Rome, a non-endemic area, has been made. The evaluation of neonatal urinary iodine excretion in the two areas showed significantly lower iodine urinary excretion levels in Urbino than in Rome. A shift of TSH at screening toward higher values as well as a higher percentage of recall in Urbino area than in Rome was observed. This finding, which well correlates with a low environmental iodine supply, emphasizes the importance of screening for congenital hypothyroidism as a suitable index of the presence and action of goitrogenic factors in the environment.
authors.affiliation: Istituto Superiore di Sanita, Roma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Carta Sorcini
authors.forename: A
authors.initials: A
authors.lastname: Diodato
authors.forename: C
authors.initials: C
authors.lastname: Fazzini
authors.forename: G
authors.initials: G
authors.lastname: Sabini
authors.forename: S
authors.initials: S
authors.lastname: Carta
authors.forename: M E
authors.initials: ME
authors.lastname: Grandolfo
authors.forename: M
authors.initials: M
authors.lastname: Guidi
authors.forename: M
authors.initials: M
authors.lastname: Vasta
authors.forename: J
authors.initials: J
authors.lastname: Locatelli De Maestri
authors.forename: L
authors.initials: L
authors.lastname: Donati
mesh_terms: D002675:Child, Preschool; D003409:Congenital Hypothyroidism; D004781:Environmental Exposure; D005500:Follow-Up Studies; D006043:Goiter, Endemic / Q000453:epidemiology; D006801:Humans; D007037:Hypothyroidism / Q000378:metabolism; D007231:Infant, Newborn; D007455:Iodine / Q000172:deficiency* / Q000652:urine; D007558:Italy; D008403:Mass Screening / Q000379:methods; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine