title: S-adenosylhomocysteine metabolism in Streptomyces flocculus.
abstract: S-Adenosylhomocysteine metabolism was studied in cell extracts of streptonigrin-producing Streptomyces flocculus. The major route of metabolism was found to be deamination to form S-inosylhomocysteine. The metabolite was purified by high-performance liquid chromatography and identified by its UV and nuclear magnetic resonance spectra and by its chemical degradation to hypoxanthine.
authors.affiliation: Department of Medicinal Chemistry/Pharmacognosy, School of Pharmacy, University of Maryland, Baltimore 21201.
authors.forename: M K
authors.initials: MK
authors.lastname: Speedie
authors.forename: J J
authors.initials: JJ
authors.lastname: Zulty
authors.forename: P
authors.initials: P
authors.lastname: Brothers
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006710:Homocysteine / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D007288:Inosine / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D012435:S-Adenosylhomocysteine / Q000302:isolation & purification / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D006710:Homocysteine; C057008:S-inosylhomocysteine; D007288:Inosine; D012435:S-Adenosylhomocysteine