title: [The modern, pharmacologically oriented prescription].
abstract: Making up a prescription is only expedient, when a pharmacologically reasoned therapeutical concept cannot be carried out with ready-made specialties. The possibilities of scientifically oriented external treatment are exemplarily demonstrated by treatment with antiinflammatory externals. We recommend the so-called step therapy, i.e. starting with a powerful corticoid, changing to a moderately strong corticoid after a few days, and finally, as soon as possible, using hydrocortisone only. At least from time to time, this treatment should be replaced by the application of Bufexamac. The concept of stepwise therapy largely reduces the hazard of loss in efficacy due to the tachyphylaxia phenomenon, as well as the risk of side effects. Since frequently allergological risk patients are concerned, treatment with the active substances mentioned must be possible using the same base in variable concentrations. In addition, the base must meet the requirements for hypoallergenicity. We make suggestions for a therapeutical concept of this kind based on the frequency of sensitizations, which occurred in the cases reported at the Dermatological Clinic in Karlsruhe (FRG).
authors.affiliation: Hautklinik am Klinikum der Stadt Karlsruhe.
authors.forename: M
authors.initials: M
authors.lastname: Gloor
authors.forename: W
authors.initials: W
authors.lastname: Gehring
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use*; D006801:Humans; D012871:Skin Diseases / Q000188:drug therapy*; D013810:Therapeutic Equivalency
chemical_list: D000305:Adrenal Cortex Hormones; D003879:Dermatologic Agents
vernacular_title: Moderne, pharmakologisch orientierte Rezeptur.