title: The transfer coefficients for L-valine and the rate of incorporation of L-[1-14C] valine into proteins in normal adult rat brain.
abstract: An autoradiographic method for the measurement of the rate of valine incorporation into brain proteins is described. The transfer coefficients for valine into and out of the brain and the rate of valine incorporation into normal rat brain proteins are given. The valine incorporation and the transfer constants of valine between different biological compartments are provided for 14 gray matter and 2 white matter structures of an adult rat brain. The rate of valine incorporation varies between 0.52 +/- 0.19 nmol/g/min in white matter and 1.94 +/- 0.47 in inferior colliculus (gray matter). Generally, the rate of valine incorporation is about three to four times higher in the gray matter than in the white matter structures.
authors.affiliation: Cone Laboratory for Neurosurgical Research, Montreal Neurological Institute, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Kirikae
authors.forename: M
authors.initials: M
authors.lastname: Diksic
authors.forename: Y L
authors.initials: YL
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D005260:Female; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013997:Time Factors; D014018:Tissue Distribution; D014633:Valine / Q000378:metabolism*
chemical_list: D002250:Carbon Radioisotopes; D009419:Nerve Tissue Proteins; D014633:Valine