title: Spreading depression is not associated with neuronal injury in the normal brain.
abstract: This study was performed in order to evaluate whether waves of spreading depression (SD) induces irreversible neuronal injury. SD was elicited by topical application of 3 M KCl to the exposed cortex for 4-5 h and the resulting change of the cortical electrical potential showing the occurrence of SD, was recorded by glass microelectrodes. Histological examination of cerebral cortex revealed no signs of neuronal injury outside the area of KCl application as examine after 4 days recovery. The results indicate that recurrent waves of SD do not induce irreversible neuronal injury in the otherwise normal rat brain.
authors.affiliation: Institute of General Physiology and Biophysics, Panum Institute, University of Copenhagen, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Nedergaard
authors.forename: A J
authors.initials: AJ
authors.lastname: Hansen
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology*; D013181:Cortical Spreading Depression; D008297:Male; D009336:Necrosis; D009474:Neurons / Q000502:physiology* / Q000503:physiopathology; D010296:Parietal Lobe / Q000473:pathology; D011189:Potassium Chloride / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
chemical_list: D011189:Potassium Chloride