Enhanced myocardial preservation by nicotinic acid, an antilipolytic compound. Improved cardiac performance after hypothermic cardioplegic arrest.
The effect of nicotinic acid, an antilipolytic drug, on myocardial preservation was studied on the basis of cardiac performance after 2 hours of cardioplegic arrest. Isolated in situ pig hearts were subjected to 120 minutes of hypothermic potassium (35 mEq) crystalloid cardioplegic arrest followed by 60 minutes of reperfusion. The experimental group received nicotinic acid 0.08 mmol/L 15 minutes before cardioplegic arrest, whereas the control group received 15 minutes of unmodified perfusion. There was a marked decline in myocardial creatine phosphate levels during cardioplegic arrest in both groups that returned to the baseline level during reperfusion without a significant intergroup difference, and adenosine triphosphate levels remained stable throughout the experiment in both groups. Myocardial oxygen consumption during reperfusion was significantly higher in hearts treated with nicotinic acid, which was consistent with a significantly greater cardiac contractile force as evaluated by isovolumetric left ventricular pressure measurements. There appeared to be less cardiac membrane damage as measured by creatine kinase release during reperfusion, which was significantly inhibited by treatment with nicotinic acid. The present study supports the conclusion that nicotinic acid improves cardiac performance after hypothermic cardioplegic arrest.
Otani
H
H
Department of Surgery, University of Connecticut School of Medicine, Farmington.
Engelman
R M
RM
Datta
S
S
Jones
R M
RM
Cordis
G A
GA
Rousou
J A
JA
Breyer
R H
RH
Das
D K
DK
D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D002314:Cardioplegic Solutions; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006324:Heart Arrest, Induced; D008297:Male; D009206:Myocardium / Q000032:analysis; D009525:Niacin / Q000494:pharmacology*; D010101:Oxygen Consumption; D010477:Perfusion; D010725:Phosphocreatine / Q000032:analysis; D013552:Swine; D013997:Time Factors
D002314:Cardioplegic Solutions; D005230:Fatty Acids, Nonesterified; D010725:Phosphocreatine; D009525:Niacin; D000255:Adenosine Triphosphate