title: Poor sulphoxidation ability in patients with food sensitivity.
abstract: Patients with well defined reactions to foods were examined for their ability to carry out both sulphur and carbon oxidation reactions by using carbocisteine and debrisoquine as probe compounds. The proportion of poor sulphoxidisers (58 of 74) was significantly greater than that of a previously determined normal control population (67 of 200; p less than 0.005). The proportion of poor carbon oxidisers was not significantly different from the controls. Metabolic defects may play a part in the pathogenesis of adverse reactions to foods.
authors.affiliation: Department of Immunology, Middlesex Hospital Medical School, London.
authors.forename: G K
authors.initials: GK
authors.lastname: Scadding
authors.forename: R
authors.initials: R
authors.lastname: Ayesh
authors.forename: J
authors.initials: J
authors.lastname: Brostoff
authors.forename: S C
authors.initials: SC
authors.lastname: Mitchell
authors.forename: R H
authors.initials: RH
authors.lastname: Waring
authors.forename: R L
authors.initials: RL
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D002233:Carbocysteine / Q000378:metabolism / Q000652:urine; D002244:Carbon / Q000378:metabolism*; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000378:metabolism / Q000652:urine; D005260:Female; D005512:Food Hypersensitivity / Q000378:metabolism* / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D013455:Sulfur / Q000378:metabolism* / Q000652:urine
chemical_list: C012359:4-hydroxydebrisoquin; D013455:Sulfur; D002233:Carbocysteine; D002244:Carbon; D003647:Debrisoquin