Minimal change nephropathy and pemphigus vulgaris associated with penicillamine treatment of rheumatoid arthritis.
A 51-year-old man developed pemphigus vulgaris, minimal change nephropathy and acute tubular necrosis after 11 months of treatment with penicillamine for rheumatoid arthritis associated with features of Reiter's syndrome. Penicillamine is a polyclonal B lymphocyte activator in animals and precipitates a variety of autoimmune reactions in man. The pathogenesis of minimal change nephropathy is obscure, but our observations support the possibility that autoimmune mechanisms play a role.
Savill
J S
JS
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.
Chia
Y
Y
Pusey
C D
CD
D058186:Acute Kidney Injury / Q000139:chemically induced*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001327:Autoimmune Diseases / Q000139:chemically induced*; D006801:Humans; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000139:chemically induced*; D010392:Pemphigus / Q000139:chemically induced*; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
D010396:Penicillamine