Autoregulated instability of beta-tubulin mRNAs by recognition of the nascent amino terminus of beta-tubulin.
Tubulin synthesis in animal cells is controlled by an autoregulatory mechanism that modulates the stability of polysome-bound tubulin messenger RNAs. The beta-tubulin RNAs are selectively targeted as substrates for destabilization not through the recognition of specific RNA sequences, but rather through co-translational recognition of the amino-terminal beta-tubulin tetrapeptide after its emergence from the ribosome. This motif is likely to be used in other systems where RNA degradation is coupled to ribosome attachment and translation.
Yen
T J
TJ
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Machlin
P S
PS
Cleveland
D W
DW
D000595:Amino Acid Sequence; D008957:Models, Genetic; D009154:Mutation; D014176:Protein Biosynthesis; D012333:RNA, Messenger; D012045:Regulatory Sequences, Nucleic Acid; D014404:Tubulin / Q000235:genetics*
D012333:RNA, Messenger; D014404:Tubulin