Pharmacokinetics of two multiple-dose mezlocillin regimens.
The pharmacokinetics of mezlocillin at two dosages were studied over the course of therapy in 12 patients receiving the drug for the treatment of infections. Patients received an initial dosing regimen of 4 g every 6 h or 5 g every 8 h, which was switched to the alternative regimen after 5 days of treatment. Both drug regimens demonstrated similar pharmacokinetic characteristics, which suggests that the reported dose-dependent elimination of mezlocillin is not an important factor in the clinical use of mezlocillin at the dosages currently used.
Janicke
D M
DM
Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo 14260.
Parker
S W
SW
Cafarell
R F
RF
Apicella
M A
MA
Jusko
W J
WJ
D000328:Adult; D001424:Bacterial Infections / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008802:Mezlocillin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy; D011897:Random Allocation; D012141:Respiratory Tract Infections / Q000188:drug therapy; D018805:Sepsis / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy
D008802:Mezlocillin