Molecular analysis of hemoglobin H disease in Taiwan.
The molecular basis of seven Chinese patients in Taiwan with hemoglobin H disease was investigated and was found to be heterogeneous in the mutation type. They were alpha-thalassemia-1 mutation combined with hemoglobin Constant Spring, an undetermined nondeletion form of alpha-thalassemia and a deletion form of alpha-thalassemia-2 mutations. The alpha-thalassemia-1 mutation was shown to be the --SEA type I haplotype.
Lee
H H
HH
Department of Medical Research, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Cheung
W F
WF
Chang
J G
JG
Liu
T C
TC
Leung
W Y
WY
Ng
H T
HT
Choo
K B
KB
D000328:Adult; D002648:Child; D004247:DNA / Q000032:analysis; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D013789:Thalassemia / Q000235:genetics*
D004247:DNA