Effects of the Xenopus laevis mitochondrial single-stranded DNA-binding protein on the activity of DNA polymerase gamma.
The single-stranded DNA-binding protein from Xenopus laevis oocyte mitochondria, which has been found associated with the D loop, binds to ssDNA in stoichiometric amounts and can under certain conditions stimulate the activity of the DNA polymerase gamma. Its properties suggest that it is involved in strand displacement during the replication of the mitochondrial genome.
Mignotte
B
B
Laboratoire de Biologie Générale, Université de Paris-Sud, Orsay, France.
Marsault
J
J
Barat-Gueride
M
M
D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D004258:DNA Polymerase III / Q000378:metabolism*; D004261:DNA Replication; D004277:DNA, Single-Stranded / Q000494:pharmacology*; D004268:DNA-Binding Proteins / Q000494:pharmacology*; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D008928:Mitochondria / Q000201:enzymology* / Q000378:metabolism; D013698:Templates, Genetic; D014981:Xenopus / Q000378:metabolism*
D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins; D004258:DNA Polymerase III; D004259:DNA-Directed DNA Polymerase