Presence of tetrahydroisoquinoline and 1-methyl-tetrahydro-isoquinoline in foods: compounds related to Parkinson's disease.
This is the first report confirming the presence of 1,2,3,4-tetrahydroisoquinoline (TIQ) and 1-methyl-1,2,3,4-tetrahydroisoquinoline(1MeTIQ) in a number of foods with a high 2-phenylethylamine content. These compounds were determined by gas chromatography-mass spectrometry. This study also confirmed that 1MeTIQ and TIQ can cross the blood-brain barrier in rat. Thus, these compounds, suspected to have relation to parkinson's disease, may accumulate in the brain from food sources.
Makino
Y
Y
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Ohta
S
S
Tachikawa
O
O
Hirobe
M
M
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D002099:Cacao / Q000032:analysis; D002611:Cheese / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D005504:Food Analysis; D008401:Gas Chromatography-Mass Spectrometry; D007546:Isoquinolines / Q000032:analysis* / Q000493:pharmacokinetics; D008297:Male; D010300:Parkinson Disease / Q000209:etiology*; D010627:Phenethylamines / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D044005:Tetrahydroisoquinolines; D014920:Wine / Q000032:analysis
D007546:Isoquinolines; D010627:Phenethylamines; D044005:Tetrahydroisoquinolines; C050386:1-methyl-1,2,3,4-tetrahydroisoquinoline; C014843:1,2,3,4-tetrahydroisoquinoline