Effects of single and long-term metoclopramide administration on open field and stereotyped behavior of rats.
The effects of single and long-term metoclopramide administration on rat open-field and apomorphine-induced stereotyped behavior were studied. A single dose of metoclopramide decreased dose dependently not only locomotion and rearing frequencies in the open field but also the apomorphine effects. Withdrawal from long-term metoclopramide administration induced a significant increase in all parameters of activity recorded in the open field. The responsiveness to apomorphine was also augmented in metoclopramide-withdrawn rats. These results were considered to be a consequence of the supersensitivity of central dopaminergic receptors.
Frussa-Filho
R
R
Department of Physiology, School of Medicine, Marília, SP, Brazil.
Palermo-Neto
J
J
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000523:psychology
D008787:Metoclopramide; D001058:Apomorphine