Enkephalin hydrolysis in plasma is highly correlated with escape performance in the rat.
A very high correlation was found in rats between latency to escape on the first trial of an active avoidance task and the rate at which [leu]enkephalin is hydrolyzed in plasma. In addition, the rate of [leu]enkephalin hydrolysis is significantly altered following the first training trial. The results suggest that a regulatory enzyme system exists for [leu]enkephalin in plasma and that this system may be important for modulating behavior.
Martinez
J L
JL
Department of Psychology, University of California, Berkeley 94720.
Weinberger
S B
SB
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D004743:Enkephalin, Leucine / Q000097:blood*; D004924:Escape Reaction / Q000502:physiology*; D006868:Hydrolysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000502:physiology
D004743:Enkephalin, Leucine