Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Syrian golden hamster.
The carcinogenic potential of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined in Syrian golden hamsters, at different dose levels. Twenty-one percent of the hamsters that received a total of 600 micrograms/kg body weight of TCDD either by the s.c. or i.p. route developed squamous cell carcinomas of the skin of facial region within 12-13 months from the beginning of the experiment. Neoplasms were not observed in any other organs. These studies suggest that TCDD may be a complete carcinogen in hamsters, the species most resistant to the toxic effect of this compound.
Rao
M S
MS
Department of Pathology, Northwestern University Medical School, Chicago, IL 60611.
Subbarao
V
V
Prasad
J D
JD
Scarpelli
D G
DG
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced*; D006224:Cricetinae / Q000502:physiology*; D004147:Dioxins / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005153:Facial Neoplasms / Q000139:chemically induced; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008647:Mesocricetus / Q000502:physiology*; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D012878:Skin Neoplasms / Q000139:chemically induced*
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins