title: Cholinergic REM sleep induction by arecoline in normal subjects: relation to thyroid function.
abstract: Serum thyroid hormones and the speed of rapid eye movement (REM) sleep induction by the central muscarinic agonist arecoline were measured in 21 normal volunteers. The arecoline-REM induction latencies had a modestly significant negative correlation with free thyroxine index. This finding is discussed in the light of observations in animal studies that thyroid hormones stimulate central cholinergic neuronal function.
authors.affiliation: Department of Psychiatry, Wayne State University, Detroit, MI.
authors.forename: M
authors.initials: M
authors.lastname: Keshavan
authors.forename: S
authors.initials: S
authors.lastname: Dubé
authors.forename: J
authors.initials: J
authors.lastname: Grabowski
authors.forename: N
authors.initials: N
authors.lastname: Sitaram
mesh_terms: D000328:Adult; D001115:Arecoline / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects*; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D011950:Receptors, Cholinergic; D014284:Triiodothyronine; D001115:Arecoline; D013974:Thyroxine