Amplification of c-myc and pvt-1 homologous sequences in acute nonlymphatic leukemia.
Leukemic cells with double minute (DM) chromosomes from an ANLL(M1) patient were found to carry 10-15 fold amplified c-myc sequences. The linked pvt-1-like locus was amplified at the same level, suggesting that the c-myc amplicon is at least 300 kb in size.
Asker
C
C
Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
Mareni
C
C
Coviello
D
D
Ingvarsson
S
S
Sessarego
M
M
Origone
P
P
Klein
G
G
Sumeigi
J
J
D000208:Acute Disease; D001483:Base Sequence; D005784:Gene Amplification; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011519:Proto-Oncogenes; D012689:Sequence Homology, Nucleic Acid