Possible involvement of the central GABAergic system in pentobarbital-stimulated gastric acid secretion in the perfused rat stomach preparation.
The effects of several convulsants and diazepam on pentobarbital-stimulated gastric acid secretion were studied in the perfused stomach of rats under urethane anesthesia. Picrotoxin and pentylenetetrazol, GABA antagonists, and 3-mercaptopropionic acid, an inhibitor of GABA biosynthesis, strongly inhibited the pentobarbital-stimulated gastric acid secretion. The secretory action of pentobarbital was transiently depressed by strychnine, a glycine antagonist, and by bicuculline, a GABA antagonist; vigorous convulsions were observed in these rats. Diazepam had no effect on the pentobarbital-stimulated gastric acid secretion. These findings suggest that the potentiation of central GABAergic mediation by pentobarbital could be a main mechanism involved in pentobarbital-stimulated gastric acid secretion.
Lin
W C
WC
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Yano
S
S
Watanabe
K
K
D015097:3-Mercaptopropionic Acid / Q000494:pharmacology; D000758:Anesthesia; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000494:pharmacology; D010477:Perfusion; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014520:Urethane; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D015097:3-Mercaptopropionic Acid; D001640:Bicuculline; D003975:Diazepam; D010424:Pentobarbital; D010433:Pentylenetetrazole; D010852:Picrotoxin; D014520:Urethane; D005680:gamma-Aminobutyric Acid