title: [Effect of uterine contraction stimulants on active and passive transport of Ca2+ in the fraction of myometrium sarcolemma].
abstract: Effect of drugs (quinine, sigetine, isoverine and pachycarpine) stimulating uterine contraction on active and passive Ca2+ transport was studied in cow myometrium sarcolemma. Isoverine and pachycarpine at concentrations 10(-6)-10(-2) M did not affect the systems of Ca2+ transport. Quinine at concentrations above 10(-3) M decreased the rate of Mg2+ ATP-dependent accumulation of Ca2+ and stimulated passive elimination of the cation from vesicles due to an increase in unspecific permeability of myometrial sarcolemma. Sigetine (10(-6) = 10(-2) M) did not affect the Ca2+ passive transport but inhibited uncompetitively the Mg2+ ATP-dependent accumulation of Ca2+ in sarcolemmal vesicles. Effect of sigetine as a stimulator of the uterine contractile activity is apparently based on inhibition of the calcium pump in plasmatic membrane of myometrial cells.
authors.forename: M D
authors.initials: MD
authors.lastname: Kurskiĭ
authors.forename: O P
authors.initials: OP
authors.lastname: Shinlova
authors.forename: V P
authors.initials: VP
authors.lastname: Fomin
authors.forename: S A
authors.initials: SA
authors.lastname: Kosterin
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D002417:Cattle; D005260:Female; D066298:In Vitro Techniques; D009215:Myometrium / Q000378:metabolism*; D012508:Sarcolemma / Q000378:metabolism*; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D002118:Calcium
vernacular_title: Vliianie stimuliatorov sokrashcheniia matki na aktivnyĭ i passivnyĭ transport Ca2+ vo fraktsii sarkolemmy miometriia.