Inhibition of the MtTF4 tumor growth by dexamethasone.
It is known that estradiol, but not progesterone or dihydrotestosterone, slows down the growth of the MtTF4 tumor. In the present paper, it is shown that: (1) this tumor contains glucocorticoid receptors, (2) its growth is also inhibited by treatment with dexamethasone (Dex), and (3) the growth rate of a cell line and several clones established from the tumor is negatively controlled by Dex 10(-7) M in culture medium containing 10% gelding serum. Unlike estradiol, Dex does not induce cell hypertrophy. This work suggests that the inhibition of the MtTF4 tumor growth by Dex may be due in part to a direct action on tumor cells and, taking into consideration previous reports, it allows us to forward the hypothesis that both Dex and estradiol inhibit MtTF4 tumor growth in two different ways.
Joly-Pharaboz
M O
MO
INSERM-U.34, UER Lyon Nord, Hôpital Debrousse, France.
Albaladejo
V
V
Morel
Y
Y
Trouillas
J
J
Andre
J
J
D000315:Adrenalectomy; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002999:Clone Cells; D004261:DNA Replication / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology*; D007700:Kinetics; D008940:Mitotic Index / Q000187:drug effects; D010911:Pituitary Neoplasms / Q000473:pathology*; D051381:Rats; D011916:Rats, Inbred F344
D003907:Dexamethasone