[Plasma and tissue concentration of ceftriaxone following a one-time i.v. dose of 2 g].
The concentration of ceftriaxon found in plasma and in fatty, muscular and colonic tissue after a single intravenous dose of 2 g are reported. 20 patients undergoing elective surgery of the colon were divided into five groups of 4, and ceftriaxon was given 45 min, 3, 6, 12 and 24 h before surgery. Even after 24 h the plasma and tissue concentrations were above MIC 90 for most microorganisms sensitive to ceftriaxon.
Küttel
J C
JC
Chirurgische Klinik, Kantonsspital, Fribourg.
Petropoulos
P
P
Crevoisier
C
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002443:Ceftriaxone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D003108:Colonic Diseases / Q000601:surgery*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011292:Premedication; D013997:Time Factors; D014018:Tissue Distribution
D002443:Ceftriaxone
Die Plasma- und Gewebskonzentration von Ceftriaxon nach einmaliger Gabe von 2 g i.v.