Biological effects in a chemical factory with mutagenic exposure. III. Urinary mutagenicity and thioether excretion.
Eighty-five workers in a chemical plant, in which there was an increased frequency of B-lymphocyte tumours (myelomas and lymphomas) and lung cancer, did not excrete higher amounts of thioethers in urine than 48 control subjects. The chemically exposed workers had, however, a higher excretion of thioethers in urine during shift compared to an exposure-free period. The bacterial fluctuation test showed a statistically significantly increased mutagenic activity for E. coli Wp2 uvrA, but not for Salmonella TA98, in the urine of the exposed workers compared with the controls. However, no difference in excretion was found in the chemical workers between work and an exposure free-period. Further, no association of thioether or mutagen excretion with any specific chemical exposure (e.g. ethylene oxide and formaldehyde) in the plant could firmly be established.
Hagmar
L
L
Department of Occupational Medicine, University Hospital, Lund, Sweden.
Bellander
T
T
Persson
L
L
Holmén
A
A
Attewell
R
R
Högstedt
B
B
Skerfving
S
S
D000328:Adult; D000367:Age Factors; D002617:Chemical Industry; D004781:Environmental Exposure; D006639:Histidine / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009152:Mutagenicity Tests; D009153:Mutagens / Q000652:urine*; D013440:Sulfides / Q000652:urine*
D009153:Mutagens; D013440:Sulfides; D006639:Histidine