A study of the interaction between oxytetracycline and pyridostigmine.
1. Oxytetracycline and pyridostigmine were given alone and in combination for 4 days to 12 normal male volunteers in a double-blind, randomised cross-over study. On the fifth day, the pharmacokinetic profiles of the two drugs were examined, and blood and plasma cholinesterase activity was measured. 2. No significant interaction on absorption or pharmacokinetics of either drugs was detected when they were given in combination. 3. There was a small but statistically significant increase in erythrocyte cholinesterase when oxytetracycline was given in combination with pyridostigmine, the pharmacological significance of which is not clear.
Johnston
A
A
Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK.
Hedges
A
A
Turner
P
P
D000328:Adult; D002802:Cholinesterases / Q000097:blood*; D004311:Double-Blind Method; D004347:Drug Interactions; D006801:Humans; D008297:Male; D010118:Oxytetracycline / Q000493:pharmacokinetics / Q000494:pharmacology*; D011729:Pyridostigmine Bromide / Q000493:pharmacokinetics / Q000494:pharmacology*
D002802:Cholinesterases; D011729:Pyridostigmine Bromide; D010118:Oxytetracycline