[Reactions of tumorous urinary bladders following local and systemic therapy with cytostatic drugs].
In 22 patients with bladder cancer after local chemotherapy and 13 patients after systemic chemotherapy, respectively, multiple biopsy specimens were examined histologically. Manifold hyperplastic, inflammatory, dysplastic, metaplastic and toxic alterations on the urothel, tumor cells and the lamina propria were found. This wide spectrum is the consequence of various etiological factors. On such treated cancer bladders the therapy-, age- and TuR-conditioned pathomorphological findings are running up with the known panurothelial reactions of a primary tumor in the urinary tract. We have classified the occurrence of multiple single cell necroses within the tumors as obligatory therapeutic effects. The granulomatous and degenerative stromal findings be conditioned by the therapy, if they are localized safely outside the area of previous TuR. The other reactive hyper- and dysplastic reactions be conditioned facultatively by the therapy.
Theuring
F
F
Institut für Pathologische Anatomie, Medizinischen Akademie Magdeburg.
Ecke
M
M
Lenz
E
E
Langen
L
L
D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin
Reaktionen an tumortragenden Harnblasen nach lokaler bzw. systemischer Zytostatikatherapie.