Plasma levels and renal clearance of two isomers of dopamine sulfate in patients with essential hypertension.
Two isomers of dopamine sulfate, dopamine 3-O-sulfate(3-O-S) and dopamine 4-O-sulfate(4-O-S), in the plasma and urine of patients with essential hypertension and normotensive controls were measured by HPLC-fluorometry. The plasma level of 3-O-S was significantly higher in patients with essential hypertension than in normotensive controls (20.9 +/- 2.2 pmol/ml and 16.3 +/- 1.4 pmol/ml respectively, p less than 0.05) and the plasma levels of 4-O-S were slightly increased in hypertensive patients. The plasma level of 3-O-S was correlated with the serum level of creatinine in both normotensives and hypertensives. In hypertensives, the plasma level of 3-O-S was also correlated with that of noradrenaline. However the creatinine clearances were similar in the two groups, the urinary clearance of 3-O-S was slightly lower in patients with essential hypertension than in normotensive controls. These data indicate that the plasma level of 3-O-S is elevated in essential hypertension because of the abnormality in dopaminergic metabolism and renal disturbance in its excretion.
Hashizume
K
K
Department of Medicine & Geriatrics, Osaka University Medical School, Japan.
Ogihara
T
T
Yamatodani
A
A
Yamamoto
T
T
Wada
H
H
Kumahara
Y
Y
D003404:Creatinine / Q000378:metabolism; D004298:Dopamine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism
C022807:dopamine 4-O-sulfate; C007558:dopamine 3-O-sulfate; D003404:Creatinine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine