Synthesis and biological activity of 2-lactonyl penems.
A series of potent antibacterial agents have been prepared. These agents are penems carrying a lactone ring in the C-2 position. Excellent activity against Gram-positive and Gram-negative organisms--except Pseudomonas aeruginosa--was found.
Capraro
H G
HG
Pharmaceutical Research Department, Ciba-Geigy Ltd., Basel, Switzerland.
Francotte
E
E
Kohler
B
B
Rihs
G
G
Schneider
P
P
Scartazzini
R
R
Zak
O
O
Tosch
W
W
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004355:Drug Stability; D007769:Lactams; D008968:Molecular Conformation
D000900:Anti-Bacterial Agents; D007769:Lactams