[Lysosomal hydrolase activity of the rat liver, spleen and thymus during antigenic stimulation and vitamin B6 deficiency].
Activity of cathepsins A, B, C and D and protein half-life T1/2 in rat liver, spleen and thymus tissues, content of antibody-producing cells in spleen, titer of antibodies and the complement activity were studied after antigen stimulation accompanied by vitamin B6 deficiency. Deficiency of vitamin B6 caused a distinct decrease in immune response and in activation of thiol-dependent proteinases in thymus, while the enzymatic activity was lowered in liver tissue. At the same time, the protein T1/2 was increased by 39% in liver tissue and decreased by 36% in thymus. These data suggest the importance of lysosomal thiol-dependent proteinases in immunogenesis.
Vasil'ev
A V
AV
Konovalova
L S
LS
Pletsitnyĭ
K D
KD
Ponomareva
L G
LG
Tutel'ian
V A
VA
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D003165:Complement System Proteins / Q000032:analysis; D006207:Half-Life; D006867:Hydrolases / Q000378:metabolism*; D007114:Immunization; D008099:Liver / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000201:enzymology; D013950:Thymus Gland / Q000201:enzymology; D026681:Vitamin B 6 Deficiency / Q000201:enzymology* / Q000276:immunology
D003165:Complement System Proteins; D006867:Hydrolases
Aktivnost' lizosomal'nykh gidrolaz v pecheni, selezenke i timuse krys pri antigennoĭ stimuliatsii i defitsite vitamina B6.