title: The incidence of cancer following total hip replacement.
abstract: We have studied the incidence of tumours at remote sites following total hip replacement: 1,358 individuals have been followed up for 14,286 person-years after operation. In the decade following implantation the incidence of tumours of the lymphatic and haemopoietic systems was significantly greater, and that of cancer of the breast, colon, and rectum, significantly less than expected. Whilst the association might be due in part to an effect of the prosthetic implants, other mechanisms, particularly drug therapy, require consideration.
authors.affiliation: Christchurch Hospital, Christchurch School of Medicine, University of Otago, New Zealand.
authors.forename: W J
authors.initials: WJ
authors.lastname: Gillespie
authors.forename: C M
authors.initials: CM
authors.lastname: Frampton
authors.forename: R J
authors.initials: RJ
authors.lastname: Henderson
authors.forename: P M
authors.initials: PM
authors.lastname: Ryan
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology; D003110:Colonic Neoplasms / Q000453:epidemiology / Q000209:etiology; D005500:Follow-Up Studies; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000209:etiology; D012307:Risk Factors