[Evoked potentials and the prediction of the efficacy of psychopharmaceutical agents].
The authors have studied early brain stem auditory evoked potentials (EPs) registered after a single intramuscular administration of 2.5 mg of haloperidol in 32 healthy volunteers and 14 schizophrenic patients. Haloperidol led to a significant decrease in the latency of wave V of brain stem auditory EPs in patients with schizophrenia and to its increase in normal subjects. A diminution in wave V of brain stem auditory EPs directly correlated with a reduction of psychopathology expressed in points of the Overall-Gorham scale (BPRS) and observed after one-month haloperidol treatment. The authors discuss the possibility of using changes in brain stem auditory EPs after a single administration of various psychotropics to select an optimal drug for a given patient and also as a possible supplementary diagnostic criterion.
Kolomaznik
M
M
Komzák
F
F
Haloupková
L
L
Seidl
I
I
Hronek
J
J
D000293:Adolescent; D000328:Adult; D001933:Brain Stem / Q000187:drug effects / Q000503:physiopathology; D004341:Drug Evaluation; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D006220:Haloperidol / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D011599:Psychopathology; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology
D006220:Haloperidol
Vyzvannye potentsialy i prediktsiia éffektivnosti psikhofarmatsevticheskikh sredstv.