Prochlorperazine-induced chronic cholestasis.
A patient with prochlorperazine-induced cholestasis that persisted for more than 2 years is reported. The timing of the onset of jaundice, the clinical, biochemical and histological findings and the subsequent course of this patient were typical of chlorpromazine-induced chronic cholestasis. Despite subsequent resolution of jaundice, liver biopsy performed 2 years after the onset of clinical disease showed fibrous expansion of the portal tracts with focal porto-portal and centro-portal bridging fibrosis, and paucity of inter-lobular bile ducts, a picture simulating that of primary biliary cirrhosis. Long-term follow-up is required to determine whether this patient will progress to frank cirrhosis.
Lok
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Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong.
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D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001706:Biopsy; D002779:Cholestasis / Q000139:chemically induced* / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D011346:Prochlorperazine / Q000009:adverse effects*
D002784:Cholesterol; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin; D011346:Prochlorperazine