Accumulation of glycolic acid and glyoxylic acid in serum in cases of transient hyperglycinemia after transurethral surgery.
Experimental data are presented here proving the accumulation of glycine in serum after transurethral prostatectomy and increased production of glycine metabolites: serine, alanine, glyoxylic acid, and glycolic acid. The presence of the metabolites glyoxylic acid and glycolic acid was demonstrated by gas-liquid chromatography and mass spectrometry. Glycine, glyoxylic acid, and glycolic acid possess neurological activity, so we examined the pathophysiology of the transurethral prostatectomy syndrome in view of the transient accumulation of these compounds in serum.
Perier
C
C
Laboratoire de Biochimie, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Priest en Jarez, France.
Frey
J
J
Auboyer
C
C
Richard
A
A
Aulagnier
G
G
Heritier
P
P
Gilloz
A
A
D000368:Aged; D008401:Gas Chromatography-Mass Spectrometry; D005998:Glycine / Q000097:blood*; D006016:Glycolates / Q000097:blood*; D006038:Glyoxylates / Q000097:blood*; D006801:Humans; D008297:Male; D011184:Postoperative Period; D011468:Prostatectomy
D006016:Glycolates; D006038:Glyoxylates; C031149:glycolic acid; C031150:glyoxylic acid; D005998:Glycine