title: Trichinella spiralis infections of inbred mice: genetics of the host response following infection with different Trichinella isolates.
abstract: The immune response of inbred strains of mice was studied following infection with isolates of Trichinella from a pig (P1), an arctic fox (AF1), and T. spiralis var. pseudospiralis (TP). Strains of mice previously characterized as highly resistant to a separate pig isolate of T. spiralis responded to the P1 and AF1 isolates by expelling over 80% of the worms by day 10 postinfection (PI), and by suppressing the in vitro release of newborn larvae by female worms. However, the response induced by AF1 worms was expressed more quickly when compared to responses induced by the P1 and TP isolates. The host response to TP was less as recovery was always higher at day 10 PI and antifecundity effects were not induced in TP worms even in highly resistant strains of mice. Strains of mice previously characterized as susceptible to T. spiralis infection were slow to develop resistance when compared to the resistant mouse strains, but even among the susceptible strains, infection with AF1 induced a more rapid response. The mouse strains used in these experiments allowed us to assess the role of the major histocompatibility complex (MHC) and/or non-MHC genes in influencing the responses observed. As previously reported for a pig isolate of T. spiralis, both MHC and non-MHC genes influenced the rate at which worms were expelled from the gut and the host response that limits the fecundity of adult female worms.
authors.affiliation: Department of Zoology, University of Manitoba, Winnipeg, Canada.
authors.forename: T A
authors.initials: TA
authors.lastname: Dick
authors.forename: D A
authors.initials: DA
authors.lastname: Dougherty
authors.forename: D L
authors.initials: DL
authors.lastname: Wassom
mesh_terms: D000818:Animals; D005260:Female; D006183:H-2 Antigens / Q000235:genetics; D007113:Immunity, Innate; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014234:Trichinella / Q000254:growth & development / Q000276:immunology / Q000502:physiology; D014235:Trichinellosis / Q000235:genetics / Q000276:immunology*
chemical_list: D006183:H-2 Antigens