title: Estrogen modulation of riboflavin carrier protein in the bonnet monkey (Macaca radiata).
abstract: Circulatory concentrations of riboflavin carrier protein (RCP) were quantitated in bonnet macaques by employing a heterologous radioimmunoassay involving 125I-labelled chicken RCP and its antiserum. The levels of monkey RCP in the serum seem to be governed by the estrogenic status of the animals. An increase in concentration of serum estradiol in the adult females during the menstrual cycle and early pregnancy could be correlated with enhanced serum RCP levels. Estadiol-17 beta administered to both immature female and male monkeys, specifically brought about elevated levels of RCP with a slower time course of response in males than in females. These results could be a reflection of a more rapid decline of both circulatory estrogen and RCP concentrations in male serum. Repeated administration of estradiol-17 beta to male animals led to prolonged elevated levels of RCP following estrogen administration. Thus, it would appear that the evolutionary conservation of RCPs from the aves to the primates encompasses not only their physicochemical similarities but also extends to the estrogenic modulation of their elaboration.
authors.affiliation: Department of Biochemistry, Indian Institute of Science, Bangalore.
authors.forename: S S
authors.initials: SS
authors.lastname: Visweswariah
authors.forename: P R
authors.initials: PR
authors.lastname: Adiga
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000097:blood*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008255:Macaca radiata; D008297:Male; D026901:Membrane Transport Proteins; D008597:Menstrual Cycle; D011247:Pregnancy
chemical_list: D002352:Carrier Proteins; D026901:Membrane Transport Proteins; C019079:riboflavin-binding protein; D004958:Estradiol