title: Bambuterol: clinical effects of different doses of a long-acting bronchodilator prodrug.
abstract: Sixty-eight asthmatics participated in a dose-finding study on bambuterol, a terbutaline prodrug, administered once every evening. Bambuterol administrations of 0.185, 0.270 and 0.400 mg/kg gave effective and long-lasting bronchodilation, for at least 24 h, with the two higher doses probably close to the maximal effect of the drug. Bambuterol 0.400 mg/kg was associated with more adverse effects than bambuterol 0.185 mg/kg. The side effects were those expected in oral beta 2-agonist treatment and mainly experienced by patients who had not been on oral beta 2-agonists before. The most favourable of the investigated doses was found to be 0.270 mg/kg. It can not be excluded, however, that a somewhat lower dose may still be as beneficial. This will be investigated in forthcoming studies.
authors.affiliation: Department of Lung Medicine, University Hospital, Umeå, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Sandström
authors.forename: L
authors.initials: L
authors.lastname: Asander
authors.forename: I H
authors.initials: IH
authors.lastname: Clemmensen
authors.forename: G
authors.initials: G
authors.lastname: Eklund
authors.forename: Y
authors.initials: Y
authors.lastname: Gnosspelius
authors.forename: B
authors.initials: B
authors.lastname: Klarlund Pedersen
authors.forename: G
authors.initials: G
authors.lastname: Persson
authors.forename: S
authors.initials: S
authors.lastname: Ravn
authors.forename: L
authors.initials: L
authors.lastname: Rosenhall
authors.forename: B
authors.initials: B
authors.lastname: Weeke
mesh_terms: D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004358:Drug Therapy; D005260:Female; D005541:Forced Expiratory Volume; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011355:Prodrugs / Q000627:therapeutic use*; D013726:Terbutaline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use
chemical_list: D001993:Bronchodilator Agents; D011355:Prodrugs; D013726:Terbutaline; C047766:bambuterol