title: [Effect of alternating treatment of multiple sclerosis with encorton and levamisole on IgG synthesis within the cerebrospinal fluid spaces].
abstract: A group of 16 patients with clinically certain multiple sclerosis with a remitting course were subjected to alternating treatment with medium doses of prednisone (Encorton, Polfa) and Decaris (Richter). The cerebrospinal fluid and plasma were studied before the beginning of the treatment and after one course of alternating treatment, determining the levels of IgG and albumins, and the IgG index which is an indicator of IgG synthesis within the cerebrospinal fluid spaces. It was observed that this treatment led to a reduction of IgG synthesis but the effect of the treatment was less pronounced than that of large doses of prednisone found in the previous study.
authors.affiliation: Katedry i Kliniki Neurologii AM w Poznaniu.
authors.forename: M
authors.initials: M
authors.lastname: Wender
authors.forename: G
authors.initials: G
authors.lastname: Michałowska
authors.forename: E
authors.initials: E
authors.lastname: Tokarz-Kupczyk
mesh_terms: D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D007978:Levamisole / Q000008:administration & dosage*; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D011241:Prednisone / Q000008:administration & dosage*
chemical_list: D007074:Immunoglobulin G; D007978:Levamisole; D011241:Prednisone
vernacular_title: Wpływ leczenia naprzemiennego Encortonem i levamisolem chorych na stwardnienie rozsiane na synteze IgG wewnatrz przestrzeni płynowych.