title: Metabolic products of microorganisms. 243. Pyridazomycin, a new antifungal antibiotic produced by Streptomyces violaceoniger.
abstract: Pyridazomycin, a new antifungal antibiotic produced by Streptomyces violaceoniger sp. griseofuscus (strain Tü 2557), was detected in a selective screening against Mucor hiemalis (Tü 179/180). The amino acid side chain of 1 can be seen as L-ornithine, whose gamma-nitrogen atom is part of a pyridazine ring building a quaternary ammonium system. The structure of 1 was established by spectroscopic analysis of the parent compound and degradation products. The occurrence of a pyridazine ring in microbial secondary metabolites is unique.
authors.affiliation: Institut für Organische Chemie, Universität Göttingen, FRG.
authors.forename: R
authors.initials: R
authors.lastname: Grote
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: A
authors.initials: A
authors.lastname: Zeeck
authors.forename: Z X
authors.initials: ZX
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Zähner
authors.forename: P
authors.initials: P
authors.lastname: Mischnick-Lübbecke
authors.forename: W A
authors.initials: WA
authors.lastname: König
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D002853:Chromatography, Liquid; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D011724:Pyridazines / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000032:analysis
chemical_list: D000935:Antifungal Agents; D011724:Pyridazines; C056340:pyridazomycin