Effects of novobiocin on heat shock protection against chromatid aberration induction by triethylenemelamine (TEM) and maleic hydrazide (MH) in Vicia faba.
Heat shock (10 min 40 degrees C) prior to challenge treatment with triethylenemelamine (TEM) or maleic hydrazide (MH) significantly reduced the frequency of induced chromatid aberrations in Vicia faba main root meristems. Novobiocin treatment before heat shock did not prevent heat shock protection against both clastogens; novobiocin application after heat shock prevented protective effects. These results and those obtained earlier for heat shock protection against X-ray challenge are used to discuss possible causes underlying the protective effects triggered by heat shock.
Nicoloff
H
H
Zentralinstitut für Genetik und Kulturpflanzenforschung, Akademie der Wissenschaften der D.D.R., Gatersleben.
Rieger
R
R
Michaelis
A
A
D002869:Chromosome Aberrations; D006358:Hot Temperature; D066298:In Vitro Techniques; D008300:Maleic Hydrazide / Q000494:pharmacology*; D009154:Mutation / Q000187:drug effects; D009675:Novobiocin / Q000494:pharmacology*; D010944:Plants; D011724:Pyridazines / Q000494:pharmacology*; D014265:Triethylenemelamine / Q000494:pharmacology*
D011724:Pyridazines; D009675:Novobiocin; D014265:Triethylenemelamine; D008300:Maleic Hydrazide