Extrarenal role of aldosterone in the regulation of blood pressure.
To assess the hypothesis that aldosterone may have direct vasoconstrictive action, the acute effects of canrenoate potassium (Soldactone, S), an aldosterone antagonist, on hemodynamics and hormonal responses were determined before and after the intravenous administration of 2 mg/kg S in 11 patients with primary aldosteronism (PA), 9 patients with essential hypertension (EH), and 5 patients with renovascular hypertension (RVH). S caused a significant -12 +/- 2 mm Hg decrease in MBP in PA, -5 +/- 2 mm Hg in EH, and -4 +/- 1 mm Hg in RVH. Reduction in MBP was significantly higher in PA than in the others and there was a negative correlation between changes in MBP and basal PAC. The cardiac index did not change throughout the study in all groups, which led to a significant reduction in total peripheral resistance index (TPRI) in PA but not in the others. There was a significant correlation between changes in MBP and TPRI (r = 0.82, p less than 0.01). PRA did not change throughout the study, but PAC and cortisol were significantly elevated. There were no correlations between changes in MBP and hormonal responses. In conclusion, S resulted in a significant reduction of MBP mediated by a significant reduction of TPRI. These results suggest that aldosterone may have direct vasoconstrictive action and this extrarenal effect of aldosterone may be involved in the regulation of blood pressure.
Yamakado
M
M
Department of Internal Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
Nagano
M
M
Umezu
M
M
Tagawa
H
H
Kiyose
H
H
Tanaka
S
S
D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects*; D002191:Canrenoic Acid / Q000008:administration & dosage; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006929:Hyperaldosteronism / Q000503:physiopathology; D006978:Hypertension, Renovascular / Q000503:physiopathology; D007668:Kidney / Q000502:physiology*; D008875:Middle Aged; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
D000450:Aldosterone; D002191:Canrenoic Acid; D006854:Hydrocortisone