The BB-isoenzyme is a major component of creatine kinase in skin blister fluid.
We measured levels of creatine kinase and its three isoenzymes in serum and blister fluid from 16 healthy volunteers. The BB-isoenzyme was found to be the predominant form in blister fluid while only the MM isoenzyme was found in serum. The levels of BB-isoenzyme in blister fluid decreased as the blisters aged. The source of BB-isoenzyme in blister fluid is most probably the damaged epidermis.
Paavonen
T
T
Department of Pathology, University of Helsinki, Finland.
Aronen
H
H
Saarelainen
I
I
Neittaanmäki
H
H
Hjelm
I
I
Kiistala
U
U
D000328:Adult; D001768:Blister / Q000201:enzymology*; D001826:Body Fluids / Q000201:enzymology*; D003402:Creatine Kinase / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes; D008297:Male; D012867:Skin / Q000201:enzymology*
D007527:Isoenzymes; D003402:Creatine Kinase