Abnormal pattern of mucin secretion at the resection margin of colorectal carcinomas.
In a retrospective study, we investigated 56 consecutive patients who had undergone radical intestinal resection for colorectal adenocarcinoma and who had developed local or distant recurrences of the disease. We found that the presence of a predominant sialomucin pattern at the margins of resection of the surgical specimen was correlated with a high percentage of local, endoluminal recurrence in the anastomotic mucosa. In contrast, no correlation could be found when the recurrences occurred in the outer tissues around the anastomosis or at some distance from it.
Andreola
S
S
Divisione di Anatomia Patologica e Citologia, Istituto Nazionale Tumori, Milano, Italia.
Bertario
L
L
Bombelli
L
L
Rossetti
C
C
Gennari
L
L
D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary / Q000601:surgery; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D009077:Mucins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local; D012004:Rectal Neoplasms / Q000378:metabolism* / Q000601:surgery; D012189:Retrospective Studies; D052116:Sialomucins
D009077:Mucins; D052116:Sialomucins