title: Vagal influence on cholecystokinin and neurotensin release in conscious dogs.
abstract: Cholecystokinin (CCK) release in seven conscious dogs was investigated by means of modified sham feeding. After sham feeding mean CCK concentrations rose from a basal value of 1.0 +/- 0.2 pmol/l to a peak value of 2.4 +/- 0.3 pmol/l (p less than 0.005). The release in response to sham feeding amounted to half of that seen after normal feeding. Atropine significantly altered CCK output after sham feeding (basal, 1.0 +/- 0.2 pmol/l; peak 1.3 +/- 0.3 pmol/l). Sham feeding did not affect neurotensin release. It is concluded that an important cephalic phase of CCK release exists which seems to be dependent on a cholinergic mechanism.
authors.affiliation: Dept. of General Surgery, University of Göttingen, FRG.
authors.forename: A
authors.initials: A
authors.lastname: Schafmayer
authors.forename: R
authors.initials: R
authors.lastname: Nustede
authors.forename: A
authors.initials: A
authors.lastname: Pompino
authors.forename: H
authors.initials: H
authors.lastname: Köhler
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002766:Cholecystokinin / Q000378:metabolism*; D004285:Dogs; D005502:Food; D005744:Gastric Acid / Q000378:metabolism; D009496:Neurotensin / Q000378:metabolism*; D010191:Pancreatic Polypeptide / Q000378:metabolism; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D009496:Neurotensin; D010191:Pancreatic Polypeptide; D001285:Atropine; D002766:Cholecystokinin