MAC of I-653 in beagle dogs and New Zealand white rabbits.
The minimum alveolar concentration (MAC) of I-653 was determined in six beagle dogs and four New Zealand white rabbits. The MAC values (+/- SD) were 7.2 +/- 1.0 atm % for dogs and 8.9 +/- 0.3 atm % for rabbits. Comparison of these results with published MAC values for other anesthetics indicate that I-653 is one-third to one-eighth as potent as currently available volatile anesthetics (enflurane, isoflurane, and halothane). From these data and previous reports, human MAC was projected to be approximately 5.1 atm %.
Doorley
B M
BM
Department of Pharmacology, Anaquest/BOC Health Care, Murray Hill, New Jersey.
Waters
S J
SJ
Terrell
R C
RC
Robinson
J L
JL
D000769:Anesthesia, Inhalation; D000777:Anesthetics; D000818:Animals; D000077335:Desflurane; D004285:Dogs; D007530:Isoflurane / Q000031:analogs & derivatives*; D008297:Male; D011650:Pulmonary Alveoli; D011817:Rabbits
D000777:Anesthetics; D000077335:Desflurane; D007530:Isoflurane