Dopamine enhances the neuronal activity of spatial short-term memory task in the primate prefrontal cortex.
The influence of dopamine and its antagonists on neuronal activity related to the delay period of a delayed response task was examined in the monkey prefrontal cortex. Iontophoretically applied dopamine enhanced the delay-related neuronal activity, while fluphenazine and haloperidol attenuated the activity. Sulpiride had no effect on the activity. The results suggest that dopamine promotes processing of spatial short-term memory by increasing memory-related activity in the primate prefrontal cortex, probably via D1-type dopamine receptor.
Sawaguchi
T
T
Department of Neurophysiology, Kyoto University, Inuyama City, Aichi, Japan.
Matsumura
M
M
Kubota
K
K
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D003216:Conditioning, Operant; D004298:Dopamine / Q000494:pharmacology*; D008251:Macaca; D008570:Memory, Short-Term / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*
D004298:Dopamine