[Experimental research on the antisecretory and antiulcer activity of (+/-) 15 alpha-OH-11-deoxyprostaglandin E1].
(+/-) 15 alpha-OH-11-deoxyprostaglandin E1 was found to possess a pronounced antisecretory activity at stimulation of gastric secretion in cats with pentagastrin. In rats the compound exerted the protective effect of cells of the gastric mucosa, especially on indomethacin and stress models of ulcerogenesis. The cytoprotective effect of the compound seemed to be related to its action on secretion of mucus as well as to its stimulation of zinc accumulation in cells that stabilized cell membranes and suppressed the secretory activity of mast cells.
Atare
Z A
ZA
Markov
Iu G
IuG
Freĭmanis
Ia F
IaF
Berzin'sh
M Z
MZ
Kimenis
A A
AA
D000527:Alprostadil / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D007213:Indomethacin; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D011459:Prostaglandins E, Synthetic / Q000627:therapeutic use*; D051381:Rats; D012110:Reserpine; D013276:Stomach Ulcer / Q000188:drug therapy / Q000209:etiology; D013312:Stress, Physiological / Q000150:complications
D000897:Anti-Ulcer Agents; D011459:Prostaglandins E, Synthetic; D012110:Reserpine; D010418:Pentagastrin; D000527:Alprostadil; C034008:11-deoxyprostaglandin E1; D007213:Indomethacin
Eksperimental'noe issledovanie antisekretornoĭ i protivoiazvennoĭ aktivnosti (+/-) 15 al'fa-OH-11-dezoksiprostaglandina E1.