title: Enkephalin hydrolysis in plasma is highly correlated with escape performance in the rat.
abstract: A very high correlation was found in rats between latency to escape on the first trial of an active avoidance task and the rate at which [leu]enkephalin is hydrolyzed in plasma. In addition, the rate of [leu]enkephalin hydrolysis is significantly altered following the first training trial. The results suggest that a regulatory enzyme system exists for [leu]enkephalin in plasma and that this system may be important for modulating behavior.
authors.affiliation: Department of Psychology, University of California, Berkeley 94720.
authors.forename: J L
authors.initials: JL
authors.lastname: Martinez
authors.forename: S B
authors.initials: SB
authors.lastname: Weinberger
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D004743:Enkephalin, Leucine / Q000097:blood*; D004924:Escape Reaction / Q000502:physiology*; D006868:Hydrolysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000502:physiology
chemical_list: D004743:Enkephalin, Leucine