title: Heparin and acute inflammation in the rat.
abstract: The subcutaneous injection of heparin into the dorsal cervical region of rats 30 min before the intrapedal administration of carrageenin significantly impaired the local inflammatory reaction from 2 h through to 6 h. This observation implies that the release of endogenous heparins from tissue mast cells may play a role in modulating the extent of the response to inflammatory insults.
authors.affiliation: Department of Biological Sciences, Hatfield Polytechnic, UK.
authors.forename: T H
authors.initials: TH
authors.lastname: Hanahoe
authors.forename: D R
authors.initials: DR
authors.lastname: Jones
mesh_terms: D000208:Acute Disease; D000818:Animals; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control*; D005260:Female; D006493:Heparin / Q000008:administration & dosage* / Q000502:physiology; D007279:Injections, Subcutaneous; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002351:Carrageenan; D006493:Heparin