The milk oligosaccharide, lacto-N-fucopentaose I, inhibits attachment of mouse blastocysts on endometrial monolayers.
Seven oligosaccharides isolated from human milk were tested for their effect in an in-vitro model of mouse blastocyst adhesion and trophoblast outgrowth on endometrial epithelial monolayers. One compound, lacto-N-fucopentaose I (LNF I), produced a significant reduction in the percentage of attached and outgrown blastocysts after co-culture for 72 h (P less than 0.001). No significant effect of any other tested oligosaccharide was obtained.
Lindenberg
S
S
Department of Obstetrics and Gynaecology, Rigshospitalet, University of Copenhagen, Denmark.
Sundberg
K
K
Kimber
S J
SJ
Lundblad
A
A
D000818:Animals; D001755:Blastocyst / Q000187:drug effects*; D002478:Cells, Cultured; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009844:Oligosaccharides / Q000494:pharmacology*
D009844:Oligosaccharides; C045442:lacto-N-fucopentaose I