Allopurinol kinetics after massive overdosage.
A 15-year-old girl with normal renal function took 75 tablets of allopurinol 300 mg. She did not suffer any ill-effects. Samples obtained over 84 h showed prolonged elimination of allopurinol, with a half-life of 3.6 h, and oxipurinol, with a half-life of 26 h.
Ferner
R E
RE
Regional Clinical Pharmacology Unit, Freeman Hospital, Newcastle upon Tyne, UK.
Simmonds
H A
HA
Bateman
D N
DN
D000293:Adolescent; D000493:Allopurinol / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning* / Q000652:urine; D005260:Female; D006207:Half-Life; D006801:Humans; D010117:Oxypurinol / Q000032:analysis / Q000097:blood; D014527:Uric Acid / Q000097:blood; D019820:Xanthine; D014970:Xanthines / Q000097:blood
D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D000493:Allopurinol; D010117:Oxypurinol