[Sodium oxybutyrate correction of the disorders in higher nervous activity in the progeny of alcoholized animals].
Alcoholization of female rats before pregnancy (8 g/kg) or during pregnancy (4 g/kg) leads to disturbances in the development of the offspring higher nervous activity manifested by impaired learning abilities, disordered emotional reactivity, reduced capacity to overcome stress-situation, deficit of GABAergic inhibitory processes in the cerebral cortex. An early postnatal administration of sodium hydroxybutyrate in a dose of 50 mg/kg prevents the development of the above mentioned disturbances of the higher nervous activity and neurophysiological alterations.
Ostrovskaia
R U
RU
Smol'nikova
N M
NM
Savchenko
N M
NM
Trofimov
S S
SS
Nemova
E P
EP
D000437:Alcoholism / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D006613:Higher Nervous Activity / Q000187:drug effects*; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D007858:Learning / Q000187:drug effects; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012978:Sodium Oxybate / Q000627:therapeutic use*
D006885:Hydroxybutyrates; D012978:Sodium Oxybate
Korrektsiia natriia oksibutiratom narusheniĭ vyssheĭ nervnoĭ deiatel'nosti potomstva alkogolizirovannykh zhivotnykh.