The synthesis of 2-(functionalized methyl)-1 beta-methylcarbapenems.
The synthesis of 1 beta-methylcarbapenems having a ROCH2 substituent at the 2-position is described. Their in vitro antibacterial activity and DHP-I susceptibilities are presented.
Schmitt
S M
SM
Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065.
Salzmann
T N
TN
Shih
D H
DH
Christensen
B G
BG
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams