Structure-distribution studies on some 99mTc-o-hydroxybenzyliminodiacetic acid complexes.
Biodistributions of a series of thirteen 99mTc-o-hydroxy-benzyliminodiacetic acid complexes were carried out in rats and their hepatobiliary and urinary outputs correlated with lipophilicity, molecular weight, influence of substituent and plasma protein binding. Hepatobiliary output was moderate for those ligands with large alkyl substituents [t-butyl (36%), and iso-octyl (42%)] but compared to HIDA compounds was relatively low, indicating that they would not be suitable for clinical use. Halogen substituents had only a small effect on increasing hepatobiliary output but a large effect on reducing the urinary clearance.
Maddalena
D J
DJ
Isotope Division, Australian Nuclear Science and Technology Organisation, Menai NSW.
Snowdon
G M
GM
Wilson
J G
JG
D000818:Animals; D005260:Female; D007098:Imino Acids; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D051381:Rats; D013329:Structure-Activity Relationship; D013667:Technetium; D014018:Tissue Distribution
D007098:Imino Acids; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; C046767:technetium Tc 99m iminodiacetic acid; D013667:Technetium