Antiinflammatory activities of copper-aspirinate and aspirin in adjuvant arthritic rats.
The antiinflammatory activities of copper aspirinate and aspirin were determined in adjuvant arthritic rats following oral administration for twenty-one days. Results clearly indicated that copper aspirinate acts as a mixed agonist/antagonist showing agonist action at lower doses and antagonist action at higher doses.
Kishore
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College of Pharmacy, Xavier University of Louisiana, New Orleans 70125.
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D001241:Aspirin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001835:Body Weight; D004487:Edema / Q000517:prevention & control; D005528:Foot; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; C027058:tetrakis-mu-acetylsalicylato-dicopper(II); D001241:Aspirin