Positive imaging of venous thrombi and thromboemboli with Ga-67 DFO-DAS-fibrinogen.
A newly developed thrombus imaging agent, 67Ga-DFO-DAS-fibrinogen (67Ga-fibrinogen), was used for 22 studies in 20 cases of suspected deep venous thrombosis. Increased accumulation of 67Ga-fibrinogen in venous thrombi was depicted at 48 h after injection in 10 of the 15 cases (10 of 17 studies) who showed abnormal findings in radionuclide venography. A hot spot in the lung emboli was visualized in two cases. Seven of the eight cases having anticoagulant therapy showed increased 67Ga-fibrinogen uptake, while follow-up 67Ga-fibrinogen scintigraphy after the administration of heparin and urokinase did not reveal an abnormal hot spot in one case. 67Ga-fibrinogen can be made available simply by adding 67Ga solution to a vial containing fibrinogen-DAS-DFO conjugate. In conclusion, 67Ga-fibrinogen is considered to be a promising agent for detecting active venous thrombi and to assess the effect of anticoagulant therapy.
Yamamoto
K
K
Department of Radiology and Nuclear Medicine, Kyoto University School of Medicine, Japan.
Senda
M
M
Fujita
T
T
Kumada
K
K
Fukui
K
K
Yonekura
Y
Y
Yokoyama
A
A
Torizuka
K
K
D000328:Adult; D000368:Aged; D003676:Deferoxamine; D005260:Female; D005340:Fibrinogen; D005710:Gallium Radioisotopes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013213:Starch / Q000031:analogs & derivatives*; D013924:Thrombophlebitis / Q000000981:diagnostic imaging*
D005710:Gallium Radioisotopes; C056464:gallium(67)-deferoxamine-dialdehyde starch-fibrinogen conjugate; D005340:Fibrinogen; D013213:Starch; D003676:Deferoxamine