title: Hepatic fibrin-ring granulomas in visceral leishmaniasis.
abstract: Hepatic fibrin-ring granulomas and leishmania parasites were found in the liver biopsy specimens of 3 patients with prolonged fever and hepatosplenomegaly. It was recognition of the leishmanias in the liver biopsy specimen that prompted the diagnosis in all cases. There was no evidence of Q fever, Hodgkin's disease, cytomegalovirus hepatitis, or allopurinol treatment, which are the recognized causes of hepatic fibrin-ring granulomas. This report extends the range of etiologies of hepatic fibrin-ring granulomas. As a result, leishmaniasis should always be a consideration to the pathologist and the clinician in the differential diagnosis of fibrin-ring granulomas.
authors.affiliation: Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Moreno
authors.forename: M
authors.initials: M
authors.lastname: Marazuela
authors.forename: M
authors.initials: M
authors.lastname: Yebra
authors.forename: M J
authors.initials: MJ
authors.lastname: Hernández
authors.forename: T
authors.initials: T
authors.lastname: Hellín
authors.forename: C
authors.initials: C
authors.lastname: Montalbán
authors.forename: J A
authors.initials: JA
authors.lastname: Vargas
mesh_terms: D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005337:Fibrin / Q000032:analysis; D006099:Granuloma / Q000150:complications / Q000473:pathology*; D006801:Humans; D007223:Infant; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008109:Liver Diseases, Parasitic / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011778:Q Fever / Q000473:pathology
chemical_list: D005337:Fibrin