Detection of tumors with 19F magnetic resonance imaging.
Previous 19F magnetic resonance imaging studies showed that the reticuloendothelial system can be imaged with an emulsion of perfluorooctyl bromide (PFOB). Similar techniques can be used to detect previously implanted RIF-1 tumors in mice after intravenous PFOB administration. Accumulation of PFOB within these neoplasms is due to egress of the emulsion through tumor capillary fenestrations. This is the first report in which 19F MRI and PFOB are used to detect tumors. This technique may allow clinical detection of cancer with 19F MRI.
Ratner
A V
AV
Department of Diagnostic Radiology, Stanford University Medical Center, California 94305.
Muller
H H
HH
Bradley-Simpson
B
B
Johnson
D E
DE
Hurd
R E
RE
Sotak
C
C
Young
S W
SW
D000818:Animals; D003287:Contrast Media; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D008279:Magnetic Resonance Imaging; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000175:diagnosis*
D003287:Contrast Media; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; C003072:perflubron