title: Bone healing during lower limb lengthening by distraction epiphysiolysis.
abstract: A study of limb lengthening by distraction epiphysiolysis in the rabbit tibia is presented. A special external distraction device was developed that allowed 10 mm lengthening of the leg. Bone formation in the elongated zone was studied by computed tomography and [99mTc] methylene diphosphonate (MDP) scintigraphy. Computed tomography showed bone formation proceeding for several weeks after the end of the distraction period, followed by a decrease in the amount of bone during a remodeling phase leading to the formation of a solid cortical structure. The uptake of [99mTc]MDP increased parallel to, but preceeding the actual accretion of bone, followed by a decrease during the bone remodeling phase. Uptake of the tracer will partly reflect bone metabolism, but other factors, like trauma, determine much of the uptake.
authors.affiliation: Department of Orthopaedic Surgery, Utrecht University Hospital, The Netherlands.
authors.forename: P M
authors.initials: PM
authors.lastname: Van Roermund
authors.forename: A
authors.initials: A
authors.lastname: Hoekstra
authors.forename: B M
authors.initials: BM
authors.lastname: Ter Haar Romeny
authors.forename: W
authors.initials: W
authors.lastname: Renooij
mesh_terms: D000818:Animals; D001852:Bone Lengthening / Q000379:methods*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000502:physiology*; D004838:Epiphyses / Q000601:surgery*; D011817:Rabbits; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate; D014057:Tomography, X-Ray Computed; D014945:Wound Healing
chemical_list: D013669:Technetium Tc 99m Medronate