title: [Plasma and tissue concentration of ceftriaxone following a one-time i.v. dose of 2 g].
abstract: The concentration of ceftriaxon found in plasma and in fatty, muscular and colonic tissue after a single intravenous dose of 2 g are reported. 20 patients undergoing elective surgery of the colon were divided into five groups of 4, and ceftriaxon was given 45 min, 3, 6, 12 and 24 h before surgery. Even after 24 h the plasma and tissue concentrations were above MIC 90 for most microorganisms sensitive to ceftriaxon.
authors.affiliation: Chirurgische Klinik, Kantonsspital, Fribourg.
authors.forename: J C
authors.initials: JC
authors.lastname: Küttel
authors.forename: P
authors.initials: P
authors.lastname: Petropoulos
authors.forename: C
authors.initials: C
authors.lastname: Crevoisier
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002443:Ceftriaxone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D003108:Colonic Diseases / Q000601:surgery*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011292:Premedication; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D002443:Ceftriaxone
vernacular_title: Die Plasma- und Gewebskonzentration von Ceftriaxon nach einmaliger Gabe von 2 g i.v.