title: Persistent reduction of Purkinje cell inhibition on neurones of the cerebellar nuclei after climbing fibre deafferentation.
abstract: The long lasting effects of inferior olive (IO) destruction were studied in rats treated with 3-acetylpyridine two years before. The activities of the Purkinje cells (PCs) and of their target neurones in the cerebellar nuclei (ECNs), were investigated and compared to those of a group of non-treated rats. Our results show that long-term deafferented PCs recovered a mean firing frequency similar to that of the controls while the ECNs discharge is enhanced. Furthermore, the cryodestruction of the cerebellar cortex produces a significant release of the ECNs firing in the control rats but not in the poisoned animals. Thus, it appears that IO destruction induces a permanent impairment of the inhibitory control exerted by the PCs on the activity of their target neurones.
authors.affiliation: Unité de recherches de Neurophysiologie Pharmacologique de l'INSERM (U.161), Paris, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Billard
authors.forename: H
authors.initials: H
authors.lastname: Daniel
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002529:Cerebellar Nuclei / Q000502:physiology*; D004553:Electric Conductivity; D008297:Male; D009412:Nerve Fibers / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D009847:Olivary Nucleus / Q000187:drug effects / Q000502:physiology; D011689:Purkinje Cells / Q000502:physiology*; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D012016:Reference Values
chemical_list: D011725:Pyridines; C010835:3-acetylpyridine