Inactivation of human immunodeficiency virus during human growth hormone production.
Since human immunodeficiency virus (HIV) has been found in the brains of AIDS patients, the possibility was investigated that preparations of human growth hormone (hGH) extracted from human pituitary glands harbor infectious HIV. It was found that the procedure used for extracting hGH, i.e. a combination of acid pH and 10% ethanol, totally inactivates HIV infectivity.
Dormont
D
D
Centre de Recherches, Service de Santé des Armées, Clamart, France.
Vaslin
B
B
Dubeaux
D
D
Boussin
F
F
Maillard
F
F
Deslys
J P
JP
D000998:Antiviral Agents; D002478:Cells, Cultured; D004340:Drug Contamination / Q000517:prevention & control; D000431:Ethanol / Q000494:pharmacology; D013006:Growth Hormone / Q000302:isolation & purification*; D006678:HIV / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D014462:Ultrafiltration; D014508:Urea / Q000494:pharmacology
D000998:Antiviral Agents; D000431:Ethanol; D014508:Urea; D013006:Growth Hormone