Effect of serum magnesium concentration on renal handling of phosphate in a patient with primary hypomagnesemia.
We examined a case of primary hypomagnesemia with associated hypocalcemia and hyperphosphatemia. It was found, on treatment with magnesium, that there was a significant negative correlation between the serum magnesium level and the percent tubular reabsorption of phosphate, especially when the serum magnesium concentration was above 1.0 mg/dl, in the patient. It is suggested that the serum magnesium concentration might play an important role in urinary phosphate excretion, probably in relation to the parathyroid hormone function.
Nishiyama
S
S
Department of Pediatrics, Kumamoto University Medical School, Japan.
Mitsubuchi
H
H
Ikuta
M
M
Ohta
T
T
Matsuda
I
I
D000293:Adolescent; D002112:Calcifediol / Q000494:pharmacology; D002118:Calcium / Q000097:blood; D006801:Humans; D007223:Infant; D007684:Kidney Tubules / Q000503:physiopathology*; D008274:Magnesium / Q000097:blood* / Q000494:pharmacology; D008275:Magnesium Deficiency / Q000097:blood*; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood / Q000502:physiology; D010446:Peptide Fragments / Q000097:blood; D010710:Phosphates / Q000097:blood / Q000502:physiology / Q000652:urine*
D010281:Parathyroid Hormone; D010446:Peptide Fragments; D010710:Phosphates; C023443:carboxyl-terminal parathyroid hormone; D008274:Magnesium; D002112:Calcifediol; D002118:Calcium