Clostridium botulinum toxins: nature and preparation for clinical use.
C. botulinum neurotoxins are acutely toxic materials and act by inhibiting release of the neurotransmitter acetylcholine. The specific nature of this inhibition is discussed and the preparation and purification of Type A toxin specifically for clinical use is described.
Melling
J
J
Vaccine Research and Production Laboratory, Centre for Applied Microbiology and Research, Salisbury, Wiltshire.
Hambleton
P
P
Shone
C C
CC
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D001764:Blepharospasm / Q000628:therapy; D001905:Botulinum Toxins / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D002118:Calcium / Q000037:antagonists & inhibitors; D006801:Humans; D008970:Molecular Weight; D009474:Neurons / Q000187:drug effects; D009498:Neurotoxins / Q000302:isolation & purification*; D013285:Strabismus / Q000628:therapy; D013574:Synaptosomes / Q000187:drug effects
D009498:Neurotoxins; D001905:Botulinum Toxins; D000109:Acetylcholine; D002118:Calcium