Predictive value of flow cytometric DNA-analysis on fresh retinoblastoma tissue.
The cellular DNA content and the distribution of tumour cells in different phases of the cell cycles has been analysed in 8 consecutive enucleated eyes with retinoblastoma. All tumours had abnormal ploidy levels. The analysis did not reveal any specific pattern in 2 tumours which had metastasized compared to 6 local tumours. The flow cytometric analysis alone or in combination with histopathology appeared not to improve the classification of large retinoblastomas.
Winther
J
J
Department of Ophthalmology, Arhus University Hospital, Denmark.
Ehlers
N
N
Jensen
O A
OA
Overgaard
J
J
Prause
J U
JU
D002675:Child, Preschool; D004273:DNA, Neoplasm / Q000032:analysis* / Q000235:genetics; D005134:Eye Neoplasms / Q000032:analysis* / Q000235:genetics; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D011003:Ploidies; D011379:Prognosis; D012175:Retinoblastoma / Q000032:analysis* / Q000235:genetics
D004273:DNA, Neoplasm