Cross-species grafting of embryonic mouse and grafting of older postnatal rat retinas into the lesioned adult rat eye: the importance of cyclosporin A for survival.
Embryonic day-15 mouse retinas were grafted into an adult rat retinal lesion site and allowed to survive for 9 and 30 days. Grafted animals received either no Cyclosporin A treatment, treatment for the first 10 days of transplantation or continuous treatment. In a second experimental set up, postnatal day-21 rat retinas were grafted under the same conditions and received either no Cyclosporin A administration, treatment during the first 24 h or continuous treatment over a 6-day survival period. Our results show that continuous Cyclosporin A treatment is necessary for successful cross-species grafting as well as to maintain for some time partly viable day-21 rat retinal grafts.
Aramant
R
R
Department of Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103.
Turner
J E
JE
D000818:Animals; D003524:Cyclosporins / Q000627:therapeutic use*; D006085:Graft Survival / Q000187:drug effects; D051381:Rats; D012160:Retina / Q000166:cytology / Q000187:drug effects / Q000637:transplantation*; D014183:Transplantation, Heterologous
D003524:Cyclosporins