title: Low field strength magnetic resonance imaging of the spleen: results from volunteers and patients with lymphoma.
abstract: Low field strength (0.08 Tesla) magnetic resonance imaging (MRI) of the spleen with spin lattice relaxation time (T1) measurement was performed on a total of 79 healthy volunteers and 62 patients with lymphoma. Inhomogeneity was observed on the T1 images of the spleen from 25 volunteers. This was therefore considered a normal variant. The normal range of spleen T1 at 0.08 Tesla was established (362-420 msec). No influence of age on spleen T1 was detected. The range of T1 values observed in males and females was similar, although the mean spleen T1 for females was significantly longer than that for males. The sensitivity of T1 measurement for the detection of lymphoma in the spleen was poor, particularly for patients with Hodgkin's disease. In a minority of untreated patients, however, a spleen T1 value outside the normal range may indicate the presence of lymphoma in the spleen. A significant decrease in spleen T1 following treatment was observed in 9 patients who underwent serial scanning.
authors.affiliation: ICRF Department of Medical Oncology, St. Bartholomew's Hospital, London, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Richards
authors.forename: J A
authors.initials: JA
authors.lastname: Webb
authors.forename: S E
authors.initials: SE
authors.lastname: Jewell
authors.forename: A G
authors.initials: AG
authors.lastname: Stansfeld
authors.forename: T A
authors.initials: TA
authors.lastname: Lister
authors.forename: P F
authors.initials: PF
authors.lastname: Wrigley
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013154:Spleen / Q000473:pathology*