[Effect of dopamine on the antitumor immunity of patients with breast cancer].
The effect of dopamine in the test of lymphocyte adhesion inhibition in vitro was studied in patients with early (I-IIA) and advanced (IIIB-IV) stages of breast cancer (BC). It was shown that the stimulating effect of dopamine revealed at concentrations of 10(-7)-10(-5) M was blocked by haloperidol (10(-6) M). During a comparative study of dopamine effect at the early and advanced stages of BC it was found that sensitivity of lymphocytes to the stimulating effect of dopamine at the advanced stages of BS was significantly lower as compared to that at the early stages.
Kharkevich
D D
DD
D001943:Breast Neoplasms / Q000276:immunology*; D002448:Cell Adhesion / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D011954:Receptors, Dopamine / Q000187:drug effects / Q000276:immunology; D013997:Time Factors; D014407:Tumor Cells, Cultured
D011954:Receptors, Dopamine; D006220:Haloperidol; D004298:Dopamine
Vliianie dofamina na protivoopukholevyĭ immunitet u bol'nykh rakom molochnoĭ zhelezy.