Lentinellic acid, a biologically active protoilludane derivative from Lentinellus species (Basidiomycetes).
A new antimicrobial and cytotoxic sesquiterpenoid, lentinellic acid, has been isolated from submerged cultures of Lentinellus ursinus and L. omphalodes. The structure of the antibiotic was elucidated by spectroscopic methods and a single crystal X-ray analysis. 1 may be formed biogenetically by condensation of a protoilludane aldehyde 4 with a malonate unit.
Stärk
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LB Biotechnologie der Universität, Kaiserslautern, Bundesrepublik Deutschland.
Anke
T
T
Mocek
U
U
Steglich
W
W
Kirfel
A
A
Will
G
G
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification*; D001419:Bacteria / Q000187:drug effects; D001487:Basidiomycota / Q000254:growth & development*; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D012717:Sesquiterpenes; C056500:lentinellic acid