title: Transnitrosating activity of N-nitroso-N-methyl-p-toluenesulfonamide in rats and human gastric juice.
abstract: N-nitroso-N-methyl-p-toluenesulfonamide (NMTS, diazald, CAS 80-11-5) is a widely used compound for laboratory production of diazomethane. The present results showed that the noncarcinogenic NMTS reacts as a transnitrosating agent with amino nitrogen of secondary amines and amide both in vitro (human gastric juice) and in vivo (rats) to yield N-nitroso compounds. Since all compounds formed (NMOR, NDMA, NPIP, NPZ, NMU) are known animal carcinogens, caution should be taken by users handling NMTS.
authors.affiliation: National Institute of Hygiene, Budapest, Hungary.
authors.forename: M
authors.initials: M
authors.lastname: Börzsönyi
authors.forename: K
authors.initials: K
authors.lastname: Sajgó
authors.forename: G
authors.initials: G
authors.lastname: Török
authors.forename: A
authors.initials: A
authors.lastname: Pintér
authors.forename: J
authors.initials: J
authors.lastname: Tamás
authors.forename: G
authors.initials: G
authors.lastname: Kolar
authors.forename: B
authors.initials: B
authors.lastname: Spiegelhalder
mesh_terms: D000577:Amides / Q000378:metabolism; D000588:Amines / Q000378:metabolism; D000818:Animals; D002273:Carcinogens; D004781:Environmental Exposure; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D009602:Nitrosamines / Q000096:biosynthesis / Q000633:toxicity*; D009603:Nitroso Compounds / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D014105:Tosyl Compounds
chemical_list: D000577:Amides; D000588:Amines; D002273:Carcinogens; D009602:Nitrosamines; D009603:Nitroso Compounds; D014105:Tosyl Compounds; C002741:N-nitrosomorpholine; C056772:diazalo