[Extracorporeal blood circulation in the unanesthetized free-moving rabbit--an animal model for biocompatibility studies].
The rabbit is suitable as a basis model for the extracorporal circuit (ECC) in long-term test (20 days). A decrease of the leucocytes and platelets is established already in the blank test qualified by catheter material and pumping influence. This effect can be compensated by the rabbit in long-term test. The typical decrease of the leucocytes and platelets does not show any significant alteration during many test days independent of the number of tests which were carried out in one rabbit (blank test and hemoperfusion). A hemoperfusion across activated carbon--independent of the albumin coating--leads to a significant decrease of the leucocytes in comparison to the blank test. This rabbit model is well-suitable for biocompatibility investigations respectively also for effective investigations of detoxication techniques taken as a basis of our results.
Böttcher
M
M
Tierexperimentellen Zentrum, Wilhelm-Pieck-Universität Rostock.
Falkenhagen
D
D
Arndt
M
M
Neumann
J
J
Nebe
B
B
Klinkmann
H
H
Ernst
B
B
D000818:Animals; D001672:Biocompatible Materials; D001792:Blood Platelets / Q000166:cytology; D005112:Extracorporeal Circulation; D006464:Hemoperfusion; D007962:Leukocytes / Q000166:cytology; D008954:Models, Biological; D011817:Rabbits
D001672:Biocompatible Materials
Extrakorporaler Blutkreislauf (ECC) am unanästhesierten, freibeweglichen Kaninchen--ein Tiermodell für Biokompatibilitätsuntersuchungen.