title: Pruritus in psoriasis. A prospective study of some psychiatric and dermatologic correlates.
abstract: Among 82 inpatients with psoriasis, 67% (55 patients) reported moderate or severe pruritus. The degree of depressive psychopathology discriminated between the mild, moderate, and severe pruritus groups at admission. Prospectively, the change in depression scores correlated with the change in pruritus pretreatment to posttreatment. Pruritus severity did not correlate significantly with stress due to life events, age at onset, ethyl duration of psoriasis, age, sex, marital status, and average reported daily alcohol (ethanol) consumption. Among the objective dermatologic measures, including extent and severity of lesions, only the degree of perilesional irritation discriminated between the mild, moderate, and severe pruritus groups at admission, and prospectively, change in this measure correlated with the change in pruritus pretreatment to posttreatment. This finding was most likely related to the self-excoriation associated with pruritus. Intrapsychic factors (eg, the severity of depression) rather than external psychosocial or well-defined dermatologic factors, were the most significant correlates of pruritus in psoriasis.
authors.affiliation: Department of Psychiatry, University of Michigan Medical Center, Ann Arbor 48109.
authors.forename: M A
authors.initials: MA
authors.lastname: Gupta
authors.forename: A K
authors.initials: AK
authors.lastname: Gupta
authors.forename: S
authors.initials: S
authors.lastname: Kirkby
authors.forename: H K
authors.initials: HK
authors.lastname: Weiner
authors.forename: T M
authors.initials: TM
authors.lastname: Mace
authors.forename: N J
authors.initials: NJ
authors.lastname: Schork
authors.forename: E H
authors.initials: EH
authors.lastname: Johnson
authors.forename: C N
authors.initials: CN
authors.lastname: Ellis
authors.forename: J J
authors.initials: JJ
authors.lastname: Voorhees
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000209:etiology; D003863:Depression / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011537:Pruritus / Q000150:complications / Q000209:etiology / Q000523:psychology* / Q000628:therapy; D011565:Psoriasis / Q000150:complications / Q000523:psychology* / Q000628:therapy; D012917:Social Adjustment; D013315:Stress, Psychological / Q000209:etiology