title: [Effect of myocardial infarct on the cholinoreactivity of the heart atria and on their acetylcholine content].
abstract: The effect of left ventricular experimental infarction (caused by left coronary artery ligation) on the isolated right atrium contractile function and acetylcholine content in both atria was studied in male Wistar rats. It was shown that a 24-hour infarction induced an increase in atrial chronotropic response to acetylcholine, which proved an increase in the pacemaker cholinoreactivity. Atrial inotropic response to acetylcholine characterizing the contractile myocardium cholinoreactivity remained unchanged. At the same time atrial endogenous acetylcholine content decreased fourfold. An increase in pacemaker cholinoreactivity was not accompanied by changes in its adrenoreactivity; those changes increased the pacemaker sensitivity to cholinergic influences which could help elucidate the ectopic excitation foci, thus promoting the onset of arrhythmia.
authors.forename: M G
authors.initials: MG
authors.lastname: Pshennikova
authors.forename: M V
authors.initials: MV
authors.lastname: Shimkovich
authors.forename: K B
authors.initials: KB
authors.lastname: Vinnitskaia
mesh_terms: D000109:Acetylcholine / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
chemical_list: D000109:Acetylcholine
vernacular_title: Vliianie infarkta miokarda na kholinoreaktivnost' predserdiĭ i soderzhanie v nikh atsetilkholina.