Retinal S-antigen immunoreactivity in medulloblastomas.
A series of 16 cerebellar medulloblastomas were studied immunohistochemically using a four-step immunoperoxidase (PAP) method and a monoclonal antibody (MAbA9-C6) which defines an epitope of the retinal S-antigen, a protein known to occur in retinal photoreceptor cells and pinealocytes of the pineal gland as well as in retinoblastomas, pineocytomas and pineoblastomas. Immunopositivity was demonstrated in a variable number of tumor cells in 50% of the cases. This finding may be an indication of a differentiation potential of medulloblastomas along the photoreceptor cell lineage. Alternatively, it may simply indicate the non-specificity of the retinal antigen in the neoplastic state.
Bonnin
J M
JM
Division of Anatomic Pathology/Neuropathology, University of Alabama School of Medicine, Birmingham 35294.
Perentes
E
E
D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis*; D019393:Arrestin; D002528:Cerebellar Neoplasms / Q000032:analysis*; D005136:Eye Proteins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008527:Medulloblastoma / Q000032:analysis*
D000911:Antibodies, Monoclonal; D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins