title: In vitro inhibition of xanthine oxidase by azapropazone and 8-hydroxy-azapropazone.
abstract: It has been demonstrated that the nonsteroidal antiinflammatory agent azapropazone (Prolixan) as well as its principal 8-hydroxy-metabolite have distinct xanthine oxidase inhibitory activity. The pharmacological spectrum of this compound has thus shown an interesting extension.
authors.affiliation: Biology and Research Department, Siegfried Ltd., Zofingen, Switzerland.
authors.forename: U
authors.initials: U
authors.lastname: Jahn
authors.forename: K
authors.initials: K
authors.lastname: Thiele
mesh_terms: D000493:Allopurinol / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001032:Apazone / Q000031:analogs & derivatives / Q000494:pharmacology*; D066298:In Vitro Techniques; D013056:Spectrophotometry, Ultraviolet; D014227:Triazines / Q000494:pharmacology*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014227:Triazines; C038301:6-hydroxyazapropazone; D000493:Allopurinol; D014969:Xanthine Oxidase; D001032:Apazone