title: Acute effects on psychomotor performance of binedaline alone and with alcohol.
abstract: The effects of single oral doses of binedaline (100 mg), imipramine (50 mg) and placebo administered without and with alcohol (0.8 g/kg) were compared on performance tasks (posturographic recordings, i.e., body sway to study alertness, squares test to explore attention and concentration) and subjective assessments in 12 healthy volunteers. The tasks were completed 1.4 and 8 h after drug administration. Blood samples were collected at the same times. Binedaline had no significant effects on any of the task parameters and did not interact with alcohol. Imipramine alone impaired performance at 4 h as shown on posturographic parameters. These disturbances were potentiated by the intake of alcohol. No pharmacokinetic interaction was noted.
authors.affiliation: Roussel Uclaf, Romainville, France.
authors.forename: A
authors.initials: A
authors.lastname: Patat
authors.forename: M J
authors.initials: MJ
authors.lastname: Klein
authors.forename: R W
authors.initials: RW
authors.lastname: Jones
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000097:blood / Q000494:pharmacology*; D004311:Double-Blind Method; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood / Q000494:pharmacology; D007211:Indoles / Q000097:blood / Q000494:pharmacology*; D008297:Male; D011187:Posture; D011597:Psychomotor Performance / Q000187:drug effects*
chemical_list: D000928:Antidepressive Agents; D007211:Indoles; C044680:binedaline; D000431:Ethanol; D007099:Imipramine