Rectal absorption of propylthiouracil.
The rectal absorption of propylthiouracil (PTU) was studied and compared to oral absorption in normal volunteers. Plasma levels of PTU after administration of suppositories of PTU base and PTU diethanolamine were significantly lower compared to the oral route. Elevated plasma reverse T3 levels were demonstrated after each treatment, however, suggesting a desirable therapeutic effect at this dosage level for all preparations.
Bartle
W R
WR
Department of Pharmacy, Sunnybrook Medical Centre, University of Toronto, North York, Ontario, Canada.
Walker
S E
SE
Silverberg
J D
JD
D000285:Administration, Rectal; D000328:Adult; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D011441:Propylthiouracil / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012007:Rectum / Q000378:metabolism; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D011441:Propylthiouracil