title: A critical period for estrogen action on neurons of the song control system in the zebra finch.
abstract: The song nuclei of the male zebra finch (Poephila guttata) contain larger neurons than those of the female. This gender difference arises after hatching as a result of cell atrophy in the female and cell growth in the male. Implantation of estrogen in female chicks induces masculine differentiation of neurons in their song nuclei. The effects of estrogen on neuron size decline steeply after posthatching day 35 when neuronal atrophy begins. Estrogen loses its masculinizing effects completely after day 45 when the adult level of neuronal atrophy is reached. Thus, the end and the intensity of hormone action appear to be correlated with the timing of neuronal atrophy.
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena 91125.
authors.forename: M
authors.initials: M
authors.lastname: Konishi
authors.forename: E
authors.initials: E
authors.lastname: Akutagawa
mesh_terms: D000818:Animals; D001717:Birds / Q000254:growth & development*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D008297:Male; D009474:Neurons / Q000187:drug effects*; D012727:Sex Characteristics; D014828:Vocalization, Animal / Q000502:physiology*
chemical_list: D004967:Estrogens