title: Zopiclone, a cyclopyrrolone hypnotic: review of properties.
abstract: Zopiclone is a non-benzodiazepine hypnotic with a pharmacological spectrum of activity which resembles that of the benzodiazepines (BZD), but it binds to the GABA complex at a site different from the BZD receptor. Pharmacokinetic properties class ZPC in the category of hypnotics with intermediate-short half-life (5-7 hours) and explain the low incidence of unwanted effects reported. The influence of zopiclone 7.5 mg on sleep architecture is minimal. In healthy volunteers, the amount of deep sleep is increased. No depressant effect on respiratory function and no rebound effect has been demonstrated.
authors.forename: J P
authors.initials: JP
authors.lastname: Brun
mesh_terms: D053961:Azabicyclo Compounds; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*
chemical_list: D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone