title: Metastatic spindle cell carcinoma: a complete response induced by cisplatin and 5-fluorouracil.
abstract: A patient with biopsy-proven spindle cell carcinoma, of unknown primary site, metastatic to the neck and to the lung, was treated with chemotherapy consisting of cisplatin (20 mg/m2/day) on days 1-5 and 5-fluorouracil (1000 mg/m2/day) on days 1-5. The regimen was repeated every 28 days. The patient had a complete response confirmed by computerized tomography. The patient is in a disease-free status 12 months after diagnosis. Toxicity was mild. To our knowledge, this case represents the first chemotherapy induced complete response documented in this rare entity.
authors.affiliation: Istituto di Clinica Medica, Università di Perugia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Colozza
authors.forename: F
authors.initials: F
authors.lastname: Grignani
authors.forename: L
authors.initials: L
authors.lastname: Crino
authors.forename: M
authors.initials: M
authors.lastname: Tonato
authors.forename: S
authors.initials: S
authors.lastname: Davis
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000556:secondary*; D006801:Humans; D009382:Neoplasms, Unknown Primary / Q000188:drug therapy* / Q000473:pathology
chemical_list: D002945:Cisplatin; D005472:Fluorouracil