title: The synthesis of 2-(functionalized methyl)-1 beta-methylcarbapenems.
abstract: The synthesis of 1 beta-methylcarbapenems having a ROCH2 substituent at the 2-position is described. Their in vitro antibacterial activity and DHP-I susceptibilities are presented.
authors.affiliation: Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065.
authors.forename: S M
authors.initials: SM
authors.lastname: Schmitt
authors.forename: T N
authors.initials: TN
authors.lastname: Salzmann
authors.forename: D H
authors.initials: DH
authors.lastname: Shih
authors.forename: B G
authors.initials: BG
authors.lastname: Christensen
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D047090:beta-Lactams
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams