Hyperthermia, hypertension, hypertonia, and coma in a massive thioridazine overdose.
This report characterizes an atypical presentation of a thioridazine overdose. Clinical manifestations included wide Q.R.S. complex, hyperthermia, hypertension, hypertonia, and coma. Plasma catecholamine levels were markedly elevated. The patient was treated with dantrolene sodium and supportive care. The patient's condition improved over time, with questionable response to dantrolene sodium. Supportive care was the mainstay of treatment.
Baker
P B
PB
Department of Emergency Medicine, University of Cincinnati, Ohio.
Merigian
K S
KS
Roberts
J R
JR
Pesce
A J
AJ
Kaplan
L A
LA
Rashkin
M C
MC
D000208:Acute Disease; D000328:Adult; D003128:Coma / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D003422:Critical Care; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D008297:Male; D009122:Muscle Hypertonia / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D013881:Thioridazine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood
D013881:Thioridazine