Voluntary alcohol intake is attenuated in two-kidney, one-clip, but not in one-kidney, one-clip Goldblatt hypertensive rats.
Voluntary alcohol intake was examined in two models of renovascular hypertension known to differ in their effects on the renin-angiotensin system. In experiment 1, Two-Kidney, One-Clip (renin-dependent) hypertensive rats (T-K,O-C) or their sham operated controls were offered limited access to alcohol for 1 hr each day. Over a four week period the T-K,O-C rats drank significantly less 3% and 6% (w/v) alcohol solution than the sham operated controls. In experiment 2, One-Kidney, One-Clip (renin-independent) hypertensive rats or their sham operated controls were offered alcohol on a similar limited access basis. Over a four week period, the O-K,O-C rats did not show a reduction in the intake of either a 3% or 6% alcohol solution compared to the sham operated controls. These results provide further documentation for the role of the renin-angiotensin system in modulating alcohol intake. The process by which this system might influence alcohol intake is outlined.
Grupp
L A
LA
Department of Pharmacology, University of Toronto, Ontario, Canada.
Perlanski
E
E
Leenen
F H
FH
Stewart
R B
RB
D000428:Alcohol Drinking / Q000502:physiology*; D000818:Animals; D003250:Constriction; D004327:Drinking Behavior / Q000502:physiology; D000431:Ethanol / Q000097:blood; D006978:Hypertension, Renovascular / Q000145:classification / Q000503:physiopathology*; D007668:Kidney / Q000502:physiology; D008297:Male; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012077:Renal Artery / Q000502:physiology; D012084:Renin-Angiotensin System
D000431:Ethanol