title: Castleman's disease of the leptomeninges. Report of three cases.
abstract: Castleman's disease is a rare, benign lymphoproliferative disorder that usually arises in lymph nodes, most commonly in the mediastinum. The authors report the clinical and pathological features of three patients with localized Castleman's disease of the leptomeninges. There were two women, aged 63 and 82 years, and one 25-year-old man. Two patients had progressive focal motor seizures of 3 and 24 months' duration, and the third patient presented acutely with generalized seizures. The clinical diagnosis was meningioma in each case, based on computerized tomography scans, cerebral arteriography, and the operative findings. All three lesions arose in the leptomeninges, compressed the underlying cerebral cortex, and infiltrated the overlying dura to a variable extent. Surgical excision of the tumor resulted in marked clinical improvement in all three patients. Histologically, two cases were classified as the hyaline-vascular type and one as the plasma cell type. Immunohistochemical stains of the latter case revealed a monoclonal population of mature plasma cells. Only a few scattered polyclonal plasma cells were seen in the other two cases. The authors conclude that Castleman's disease involving the leptomeninges is a rare disorder that may mimic meningioma clinically and radiographically.
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha.
authors.forename: G S
authors.initials: GS
authors.lastname: Severson
authors.forename: D S
authors.initials: DS
authors.lastname: Harrington
authors.forename: D D
authors.initials: DD
authors.lastname: Weisenburger
authors.forename: R D
authors.initials: RD
authors.lastname: McComb
authors.forename: J H
authors.initials: JH
authors.lastname: Casey
authors.forename: B R
authors.initials: BR
authors.lastname: Gelber
authors.forename: B
authors.initials: B
authors.lastname: Varet
authors.forename: R
authors.initials: R
authors.lastname: Abelanet
authors.forename: H H
authors.initials: HH
authors.lastname: Rappaport
mesh_terms: D000328:Adult; D000368:Aged; D005871:Castleman Disease / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology*; D008875:Middle Aged