[Protective action of liposome-incorporated surface antigens of the influenza virus by different methods of immunization].
The influence of different routes of immunization on the protective effect of liposome-incorporated influenza A/PR/8/34 virus surface antigens was studied. Influenza virus surface antigens, neuraminidase and hemagglutinin, incorporated into liposomes, were shown to have a significant protective effect upon intraperitoneal and intranasal administration against a lethal dose of influenza virus as compared with immunization using a free antigen solution against the same infection. The protective effect is poor in intravenous immunization with influenza virus antigen-containing liposomes. It is concluded that combining of influenza virus antigens with liposomes may be used for preparation of new influenza vaccines.
Burkhanov
S A
SA
Mazhul'
L A
LA
Torchilin
V P
VP
Ageeva
O N
ON
Saatov
T S
TS
D000818:Animals; D000954:Antigens, Surface / Q000008:administration & dosage / Q000276:immunology; D000956:Antigens, Viral / Q000008:administration & dosage / Q000276:immunology*; D004353:Drug Evaluation, Preclinical; D006389:Hemagglutinins, Viral / Q000008:administration & dosage / Q000276:immunology; D007114:Immunization / Q000379:methods*; D009980:Influenza A virus / Q000276:immunology*; D008081:Liposomes / Q000008:administration & dosage*; D051379:Mice; D008807:Mice, Inbred BALB C; D009439:Neuraminidase / Q000008:administration & dosage / Q000276:immunology; D009976:Orthomyxoviridae Infections / Q000401:mortality / Q000517:prevention & control*
D000954:Antigens, Surface; D000956:Antigens, Viral; D006389:Hemagglutinins, Viral; D008081:Liposomes; D009439:Neuraminidase
Protektivnoe deĭstvie vkliuchennykh v liposomy poverkhnostnykh antigenov virusa grippa pri razlichnykh sposobakh immunizatsii.