title: Prevention of stomal recurrence in patients requiring emergency tracheostomy for advanced laryngeal and pharyngeal tumors.
abstract: Since 1976, patients requiring emergency tracheostomy for advanced laryngeal and hypopharyngeal cancer at the University of Cincinnati have been treated with a short course of prelaryngectomy radiation in an attempt to decrease the incidence of stomal recurrence. Twenty-one patients were treated after emergency tracheostomy with a course of radiation that usually consisted of 20 Gy in five fractions followed by laryngectomy 1 or 2 days later. Most patients also received postoperative radiotherapy of some type. The follow-up of 18 evaluable patients revealed only two (11%) stomal recurrences--a quite acceptable rate for this high-risk population. Overall, however, local recurrences were seen in ten patients (56%), which is higher than reported in most series of similar tumors. The most likely explanation for this seems to be that the short course preoperative radiation prevented the administration of adequate postoperative radiation for residual disease, which was usually present. An alternative treatment policy would be a planned course of moderate- to high-dose postoperative radiation, which could sterilize tumor in the entire locoregional area including the stoma.
authors.affiliation: Division of Radiation Oncology, University of Cincinnati Hospitals, Ohio.
authors.forename: J C
authors.initials: JC
authors.lastname: Breneman
authors.forename: A
authors.initials: A
authors.lastname: Bradshaw
authors.forename: J
authors.initials: J
authors.lastname: Gluckman
authors.forename: B S
authors.initials: BS
authors.lastname: Aron
mesh_terms: D000368:Aged; D000402:Airway Obstruction / Q000601:surgery; D003131:Combined Modality Therapy; D004630:Emergencies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D007825:Laryngectomy; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009366:Neoplasm Seeding / Q000517:prevention & control*; D010610:Pharyngeal Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control*; D013997:Time Factors; D014140:Tracheotomy / Q000009:adverse effects*