Thyroxine injections do not cause premature induction of thymidine kinase in sg/sg mice.
Severe hyperthyroidism from the time of birth causes a premature induction and termination of thymidine kinase activity in the cerebella of wild-type mice. This leads to elevated enzyme levels at postnatal days 5 and 6, with significantly lower levels by postnatal day 7 (which is actually the time of peak activity in normal animals). In this study, neonatal hyperthyroidism does not have significant effects on postnatal day 5, 6, or 7 enzyme levels in the neurological mutant staggerer. This is consistent with the hypothesis that thyroid hormone exerts its effects via the Purkinje cells, which are reduced in number and grossly stunted in the mutant.
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Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201.
D000818:Animals; D000835:Animals, Wild / Q000378:metabolism; D002531:Cerebellum / Q000201:enzymology*; D004247:DNA / Q000032:analysis; D004790:Enzyme Induction / Q000187:drug effects; D005838:Genotype; D006980:Hyperthyroidism / Q000201:enzymology; D007267:Injections; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000235:genetics / Q000378:metabolism*; D013937:Thymidine Kinase / Q000378:metabolism*; D013974:Thyroxine / Q000494:pharmacology*
D004247:DNA; D013937:Thymidine Kinase; D013974:Thyroxine