A comparative study of the acute antihypertensive effect of Adalat capsules and Corinfar dragées, two different nifedipine preparations.
The calcium entry blocker nifedipine produces systemic vasodilation and decreases the elevated vascular resistance in hypertensive patients. The authors investigated the acute antihypertensive effect of sublingually administered nifedipine in two different formulas: Adalat capsules and Corinfar dragées. There was no significant difference between both these formulas regarding their effects on blood pressure and heart rate, and their side effects were also similar. The authors conclude that the acute antihypertensive effect of nifedipine, either in capsules or in dragées, is equipotent in essential hypertension.
Kiss
I
I
2nd Department of Internal Medicine, Semmelweis Medical University, Budapest, Hungary.
Farsang
C
C
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002214:Capsules; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage* / Q000627:therapeutic use; D013997:Time Factors
D002214:Capsules; D009543:Nifedipine