[Detection of the binding of 131I-meta-iodobenzylguanidine to structures of the plasma membranes of neuroblastoma cell lines].
In vitro studies of tumor tissue have shown that 131I-IBG is specifically bound to the plasma membrane-enriched fraction of two neuroblastoma cell lines (NA-2 and C-1300). NB C-1300 showed a slightly higher binding capacity than NB NA-2. It may be inferred from experiments performed with activators of the adrenergic and dopaminergic systems that binding of IBG to proteins on the plasma membrane which is physiologically important for binding of this guanidine derivative, is probable.
Busse
E
E
Zentrum der Kinderheilkunde, Johann-Wolfgang-Goethe-Universität, Frankfurt/Main, BRD.
Baum
R P
RP
Hör
G
G
Kornhuber
B
B
D019797:3-Iodobenzylguanidine; D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009447:Neuroblastoma / Q000473:pathology*; D011485:Protein Binding; D014183:Transplantation, Heterologous
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008565:Membrane Proteins; D019797:3-Iodobenzylguanidine
Nachweis der Bindung von 131J-Meta-Jod-Benzylguanidin an Strukturen der Plasmamembran von Neuroblastom-Zellinien.