Autoradiographic evaluation of vitamin A effects on Triturus alpestris blastema cells.
Autoradiographic studies on Triturus alpestris regenerates treated with vitamin A palmitate for 4, 7, 11 and 14 days after amputation, reveal a considerable diminution in the percentage of cells duplicating DNA, as judged by measurements of labelling indices. Based on previous observations, that vitamin A promotes DNA-synthesis, mitosis and growth of regenerates, we conclude that the lower labelling indices calculated are due to an acceleration of S-phase processes, resulting in a concomitant reduction in its duration.
Koussoulakos
S
S
University of Athens, Zoological Laboratory, Greece.
Anton
H J
HJ
D000818:Animals; D001345:Autoradiography; D002455:Cell Division / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D004224:Diterpenes; D005121:Extremities; D012038:Regeneration / Q000187:drug effects*; D000084562:Retinyl Esters; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014319:Triturus; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology
D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; D004247:DNA; D013936:Thymidine