title: Does the study of anaerobic metabolism give quantitative information on left ventricular dysfunction during exercise?
abstract: The anaerobic threshold (AT) has been proposed as an index to assess the functional status of patients with chronic heart failure. The focus of this report was to evaluate in post-myocardial infarction patients the utility of the AT for (a) assessing the severity of exercise-induced left ventricular impairment, (b) determining the responses obtained from different treatments and (c) prescribing exercise training. We found that the AT level was lower in patients with abnormal haemodynamic patterns during exercise. The AT was correlated to different degrees of exercise-induced left ventricular impairment. The nitrate and calcium-antagonist effects have been evaluated in patients with abnormal exercise haemodynamics. The resting and exertional results were in agreement with the vasodilator effects. Moreover, the time from onset of exercise to the appearance of the AT was significantly increased by the treatments. Thus, AT during pharmacological treatments may be a non-invasive useful parameter for assessing their haemodynamic effects. Finally, a 4-week intermittent training programme based on AT level was evaluated in patients with abnormal resting and exertional haemodynamics. The results showed an improvement of the exercise cardiovascular tolerance without negative effects on left ventricular function. Therefore, the AT seems to be useful when prescribing a rational and individualized training programme.
authors.affiliation: Fondazione S. Maugeri, Centro di Montescano, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Opasich
authors.forename: F
authors.initials: F
authors.lastname: Cobelli
authors.forename: G
authors.initials: G
authors.lastname: Riccardi
authors.forename: M T
authors.initials: MT
authors.lastname: La Rovere
authors.forename: G
authors.initials: G
authors.lastname: Calsamiglia
authors.forename: G
authors.initials: G
authors.lastname: Specchia
mesh_terms: D000328:Adult; D000693:Anaerobiosis / Q000187:drug effects; D005080:Exercise Test; D005081:Exercise Therapy; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007773:Lactates / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D009529:Nicardipine / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D005082:Physical Exertion; D011669:Pulmonary Wedge Pressure / Q000187:drug effects
chemical_list: D007773:Lactates; D009529:Nicardipine