[Effect of the calcium antagonist nifedipine on central and peripheral hemodynamics in patients with primary pulmonary hypertension].
15 patients with primary pulmonary hypertension (PPH) were studied. An acute test with 20 mg nifedipine (N) sublingually was performed and the pulmonary artery pressure (PAP) was measured. N had manifest arterolodilating effect in the systemic and especially pulmonary circulation, induced decrease in the total peripheral and total pulmonary vascular resistance (TPerVR and TPulVR) by 21.7 and 25.3%, correspondingly. N had principal effect on pulmonary arterioles (TPerVR/TPulVR ratio increased by 16.9%). Systolic and diastolic PAP decreased in this case by 15.2 and 18.4%, correspondingly. All the patients demonstrated increase in cardiac output (on the average by 17.0%) and insignificant increase in heart rate (7.4%).
Khosseĭn
A
A
Mareev
V Iu
VIu
Ageev
F T
FT
Sazonova
L N
LN
Lobova
N M
NM
D000293:Adolescent; D000328:Adult; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use*; D011651:Pulmonary Artery / Q000503:physiopathology; D011652:Pulmonary Circulation / Q000187:drug effects*; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D009543:Nifedipine
Vliianie kal'tsevogo antagonista nifedipina na tsentral'nuiu i perifericheskuiu gemodinamiku u bol'nykh pervichnoĭ legochnoĭ gipertonieĭ.