Effect of a leukotriene D4 (LTD4) antagonist on LTD4 and ascaris antigen-induced airway responses in rhesus monkeys.
An acute airway response to aerosolized leukotriene D4 (LTD4) qualitatively simulates an IgE-mediated ascaris antigen-induced airway response. The LTD4 airway response is completely inhibited by the LTD4 antagonist, ICI 198615, in normal monkeys. This LTD4 antagonist was then evaluated to determine whether it could inhibit the IgE-mediated ascaris antigen response using the threshold antigen dose-response system or the single antigen dose-response system. In 6 ascaris airway-reactive monkeys, the LTD4 antagonist demonstrated partial inhibition in 2 animals by either the threshold dose system in 1 animal or the single dose system in another animal. In the remaining animals there was no inhibition of the antigen-induced response by the LTD4 antagonist.
Patterson
R
R
Department of Medicine, Northwestern University Medical School, Chicago, Ill.
Harris
K E
KE
Krell
R D
RD
D000818:Animals; D000947:Antigens, Helminth / Q000494:pharmacology*; D001200:Ascaris / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D007191:Indazoles / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology*; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000187:drug effects; D013189:SRS-A / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D000947:Antigens, Helminth; D007191:Indazoles; D011720:Pyrazoles; D013189:SRS-A; C054217:ICI 198615