The effect of dietary nitrite and nitrate on the metabolism of sulphadimidine administered orally to pigs.
The in vivo interaction of sulphadimidine (SDM) with nitrite and nitrate has been investigated in pigs. It was shown that the combined oral treatment with SDM and nitrite but not nitrate leads to the formation of a deaminated compound, which becomes the major metabolite in plasma soon after cessation of the treatment. The major in vitro reaction product, 1,3-di(4-[N(4,6-dimethyl-2-pyrimidinyl)]-sulphamoylphenyl)-triazen e, DDPSPT as has been reported previously, could not be detected in blood, urine or faeces of the exposed animals. No effect of nitrite or nitrate could be observed on the acetylation of SDM.
Hoogenboom
L A
LA
State Institute for Quality Control of Agricultural Products (RIKILT), Wageningen, The Netherlands.
Pijpers
A
A
van de Steeg
P W
PW
Aerts
M M
MM
Verheijden
J H
JH
Kuiper
H A
HA
D000284:Administration, Oral; D000818:Animals; D004347:Drug Interactions; D005260:Female; D009566:Nitrates / Q000008:administration & dosage / Q000378:metabolism*; D009573:Nitrites / Q000378:metabolism*; D012977:Sodium Nitrite / Q000008:administration & dosage / Q000378:metabolism*; D013418:Sulfamethazine / Q000378:metabolism*; D013552:Swine / Q000378:metabolism*; D014226:Triazenes / Q000378:metabolism*
D009566:Nitrates; D009573:Nitrites; D014226:Triazenes; C053071:1,3-di-(4(N-(4,6-dimethyl-2-pyrimidinyl))sulfamoylphenyl)triazene; D013418:Sulfamethazine; C031618:sodium nitrate; D012977:Sodium Nitrite