title: Relationship of transmural electrical parameters to the luminal Na concentration in the colon of the fowl (Gallus domesticus).
abstract: Electrical parameters: PD, resistance, Isc and amiloride-sensitive-Isc across the fowl colon (in vitro) change in response to the Na content of the diet. On a low-Na diet these changes appear to reflect increases in ion transport, especially amiloride-inhibitable Na transport. In vitro the magnitudes of the changes are related to the Na concentration in the luminal (mucosal) fluid and in birds on a low-Na diet peak at a concentration of about 12.5 mM. Such Na concentrations are similar to those in the colonic fluid of Na-deprived birds. Typical Michaelis-Menten kinetics do not appear to apply, possibly reflecting a local adaptation of the ion transport process in response to its external Na concentration.
authors.affiliation: Department of Anatomy, Physiological Sciences and Radiology, School of Veterinary Medicine, North Carolina State University, Raleigh 27606.
authors.forename: B R
authors.initials: BR
authors.lastname: Grubb
authors.forename: P J
authors.initials: PJ
authors.lastname: Bentley
mesh_terms: D000818:Animals; D002645:Chickens / Q000502:physiology*; D003106:Colon / Q000378:metabolism / Q000502:physiology*; D004594:Electrophysiology; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism*; D007700:Kinetics; D011199:Potentiometry; D012964:Sodium / Q000378:metabolism*; D012982:Sodium, Dietary / Q000008:administration & dosage
chemical_list: D012982:Sodium, Dietary; D012964:Sodium