Relationship between labeling indices of Ki-67 and BrdUrd in human malignant tumors.
The relationship between labeling indices of Ki-67 reactive antigen expressed by cycling cells and BrdUrd incorporated into S-phase cells was investigated in 20 patients with malignant tumors. Both of the labeling indices varied greatly from patient to patient; the labeling index of Ki-67 ranged from 37.5% to 1.9% with an average value of 16%, and the BrdUrd labeling index ranged from 23.4% to 1.6% with an average of 9.3%. The Ki-67 labeling index was higher than the BrdUrd labeling index. In general, the values of the Ki-67 labeling index were parallel to those of the BrdUrd labeling index, and the relation Y = 1.59X + 1.15 (r = 0.89) was obtained. In human solid tumors, therefore, the growth fraction can be easily estimated from the S-phase fraction size, and vice versa.
Sasaki
K
K
Department of Pathology, Yamaguchi University School of Medicine, Ube-shi, Japan.
Matsumura
K
K
Tsuji
T
T
Shinozaki
F
F
Takahashi
M
M
D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology; D000941:Antigens / Q000032:analysis*; D001973:Bromodeoxyuridine; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology; D002455:Cell Division; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000473:pathology*; D009687:Nuclear Proteins / Q000032:analysis*
D000941:Antigens; D009687:Nuclear Proteins; D001973:Bromodeoxyuridine