Human retinal extract stimulates the proliferation of human lens epithelial cells.
The proliferation of lens epithelial cells remaining attached to the capsule after extracapsular cataract extraction represents a potential cause of posterior capsule opacification. In view of the reported mitogenic effects of eye derived growth factors on lens epithelial cells in animal studies, we determined to establish whether the human retina produces a factor capable of inducing a similar response in human lens epithelial (HLE) cells. We report that an extract of the human neural retina is capable of increasing the proliferative capacity of HLE cells in culture by 50%. The possible mechanisms are discussed. The presence of such a growth factor in the human eye would have important consequences for the epithelial cells remaining after cataract surgery.
Jacob
T J
TJ
Department of Pharmacology, St. George's Hospital Medical School, London.
Humphry
R C
RC
Davies
E G
EG
Thompson
G M
GM
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D005346:Fibroblast Growth Factors; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D007908:Lens, Crystalline / Q000166:cytology / Q000187:drug effects*
D006133:Growth Substances; C039825:eye-derived growth factor; D005346:Fibroblast Growth Factors