[Effect of continuous mechanical hemofiltration on the pharmacokinetics of antibiotics exemplified by mezlocillin].
Pharmacokinetics of mezlocillin (70 mg/kg as an infusion) were investigated in 8 patients with multiorgan failure undergoing continuous veno-venous haemofiltration (CVVH) due to acute renal failure (HF-group) in comparison to 8 intensive care patients with an uneffected renal system (control group). Mezlocillin concentration were studied in blood, ultrafiltrate and urine (control group). Elimination of mezlocillin was prolonged in the HF-group with a t1/2 of 170 min in comparison to 109 min in the control patients. No relevant absorption at the haemofilter membrane could be observed. With regard to our results a dose reduction and intermittend application of mezlocillin is suggested; in addition, monitoring of drug levels in critically ill patients becomes of increasing interest, especially during haemofiltration.
Boldt
J
J
Abteilung Anaesthesiologie und operative Intensivmedizin, Klinikum der Justus-Liebig-Universität Giessen.
Salomon
F
F
Krumholz
W
W
Hempelmann
G
G
D058186:Acute Kidney Injury / Q000097:blood*; D003422:Critical Care; D006440:Hemofiltration; D006801:Humans; D007262:Infusions, Intravenous; D008802:Mezlocillin / Q000008:administration & dosage / Q000493:pharmacokinetics*
D008802:Mezlocillin
Einfluss der kontinuierlichen maschinellen Hämofiltration auf die Pharmakokinetik von Antibiotika am Beispiel des Mezlocillins.