[The effect of indomethacin and dexamethasone on the excretion of epinephrine, levarterenol and dopamine in the urine of rats with adjuvant arthritis].
The repeated application of indometacine or dexamethasone on rats with adjuvant arthritis results in a most cases significant inhibition of the arthritis in the primary and secondary phase as well as in a normalisation of the increased urinary excretion of epinephrine and norepinephrine of untreated arthritis rats. The dopamine excretion of adjuvant arthritis rats was also higher then the prepared rats. We suppose, that the results show the regulative endogenous excretion of epinephrine and norepinephrine in inflammatory processes. Consequently these drugs have essentially antiinflammatory activities. The inhibition of the inflammation is than connected with the normalisation of the excretion of catecholamines.
Schmollack
W
W
Sektion Pharmazie der Martin-Luther-Universität Halle-Wittenberg, Saale.
Steup
A
A
D000818:Animals; D001168:Arthritis / Q000652:urine*; D001169:Arthritis, Experimental / Q000652:urine*; D003907:Dexamethasone / Q000494:pharmacology*; D004298:Dopamine / Q000652:urine*; D004837:Epinephrine / Q000652:urine*; D007213:Indomethacin / Q000494:pharmacology*; D009638:Norepinephrine / Q000652:urine*; D051381:Rats; D013997:Time Factors
D003907:Dexamethasone; D004298:Dopamine; D009638:Norepinephrine; D007213:Indomethacin; D004837:Epinephrine
Einfluss von Indometacin bzw. Dexamethason auf die Ausscheidung von Epinephrin, Levarterenol und Dopamin im Urin von Ratten mit Adjuvansarthritis.