[Effect of bombesin on the frequency of slow potentials of the smooth muscles of the gastrointestinal tract and migrating myoelectric complex].
In dogs with electrodes implanted in the smooth muscle wall of the stomach, small intestine and colon, i.v. administration of bombesin (50, 100, 200 and 300 ng/kg) during the 2nd phase of the migrating myoelectric complex (MMC) increased the dose-dependent frequency of slow potential in the small intestine and stomach leaving unchanged the frequency of slow potentials in the colon. Single doses of 50 or 200 ng/kg bombesin during the 2nd phase of the MMC caused a short-term inhibition of the gastric and intestinal spike activity followed by its increase, the active period of the MMC being prolonged.
Kortezova
N I
NI
Mileva
S L
SL
Bagaev
V A
VA
Papazova
M P
MP
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D004064:Digestive System / Q000187:drug effects*; D004068:Digestive System Physiological Phenomena; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology
D001839:Bombesin
Vliianie bombezina na chastotu medlennykh potentialov gladkikh myshts zheudochno-kishechnogo trakta i migriruiushchiĭ mioélektricheskiĭ kompleks.