Recognition by monoclonal antibody CB02 of a surface molecule shared by B lymphocytes and a discrete large granular lymphocyte subset with cytotoxic activity.
Here we present the characterization of a new antigen called CB02 which is present on B cells and on a subset of CD16+ large granular lymphocytes. The pattern of reactivity of this molecule on normal cells, B cell lines, leukemic cells and tissue sections suggests that the CB02 molecule is expressed by B cells before isotype switch and is lost during terminal differentiation. Furthermore, the CB02+ population encompassed natural killer (NK) cells exerting significant cytotoxic activity: in fact, peripheral blood lymphocytes depleted of the CB02+ subset display a marked reduction in NK activity.
Funaro
A
A
Dipartimento di Genetica, Biologia e Chimica Medica, Università di Torino, Italia.
Bellone
G
G
Alessio
M
M
De Monte
L
L
Palestro
G
G
Matera
L
L
Caligaris Cappio
F
F
Malavasi
F
F
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis; D000943:Antigens, Differentiation / Q000032:analysis*; D002460:Cell Line; D002648:Child; D005260:Female; D005333:Fetus / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000145:classification / Q000276:immunology*; D007938:Leukemia / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D014407:Tumor Cells, Cultured / Q000276:immunology
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation