Cardiovascular effects of the novel cardiotonic agent DPI 201-106 in the anaesthetized rat.
DPI 201-106 (4-[3-(4-diphenylmethyl-1-piperazinyl)-2-hydroxypropoxy]-1H-indole -2- carbonitrile) was given intravenously to anaesthetized male rats. DPI caused an increase in left ventricular dP/dt (LV dP/dt), giving a significant increase at 0.03 mumol/kg. At this dose DPI had no effect on either mean arterial pressure (MAP) or heart rate (HR). At higher doses, MAP decreased transiently. At 0.3 and 1 mumol/kg, HR was decreased. The results indicate that DPI produces positive inotropic and negative chronotropic effects in the anaesthetized rat.
Fraser
M
M
Research Center Orion Pharmaceutica, Espoo, Finland.
Törnquist
K
K
Sellin
L C
LC
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013874:Thiopental / Q000031:analogs & derivatives / Q000494:pharmacology
D002316:Cardiotonic Agents; D010879:Piperazines; C046261:DPI 201-106; C009457:thiobarbital; D013874:Thiopental