Manganese inhibits benzoyl peroxide/copper-dependent lipid peroxidation in the microsomal fraction of rabbit dental pulp.
1. Of all the cations tested only manganese ion inhibited the benzoyl peroxide/Cu2+-dependent formation of thiobarbituric acid (TBA)-reactive substance. 2. Ki of Mn2+ for the formation of TBA-reactive substance was 5.0 microM. 3. The inhibitory manner of manganese was non competitive against copper.
Tsujimoto
Y
Y
Department of Endodontics, Nihon University School of Dentistry at Matsudo, Japan.
Nagashima
K
K
Kawashima
T
T
Takeuchi
H
H
Chiba
M
M
Hashimoto
A
A
Miyoshi
T
T
Takase
T
T
Kikuchi
Y
Y
Yamazaki
M
M
D000818:Animals; D001585:Benzoyl Peroxide / Q000494:pharmacology; D002458:Cell Fractionation; D003300:Copper / Q000494:pharmacology; D003782:Dental Pulp / Q000378:metabolism* / Q000648:ultrastructure; D008054:Lipid Peroxides / Q000378:metabolism*; D008345:Manganese / Q000494:pharmacology*; D008861:Microsomes / Q000378:metabolism; D011817:Rabbits
D008054:Lipid Peroxides; D008345:Manganese; D003300:Copper; D001585:Benzoyl Peroxide