[A new approach to selecting antibacterial preparations for treating patients with chronic urological infections].
The oral administration of microflora, isolated from the urinary tract or feces of urological patients, into the abacterial digestive tract of mice kept under the conditions of germ-free environment leads to the formation of the donors' microflora in the intestine of the recipient animals. Such recipient mice can be used as models for the rapid and highly reliable determination of the sensitivity of microflora in the patient's intestine and urinary tract to different antimicrobial preparations. In different patients such microflora, though similar in its qualitative and quantitative composition, differs in sensitivity to different antimicrobial preparations and their combinations. For the effective treatment of patients with chronic urinary tract infections a preliminary in vivo determination of the sensitivity of intestinal and urinary microflora to different combinations of antimicrobial preparations, carried out with the use of germ-free techniques, is necessary.
Korshunov
V M
VM
Nizamov
F Z
FZ
Ivanova
N P
NP
Ukhin
A V
AV
Zakhmatov
Iu M
IuM
D000328:Adult; D000368:Aged; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002908:Chronic Disease; D004755:Enterobacteriaceae / Q000187:drug effects / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology; D005856:Germ-Free Life; D006801:Humans; D051379:Mice; D008808:Mice, Inbred CBA; D008826:Microbial Sensitivity Tests / Q000379:methods; D008875:Middle Aged; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D014566:Urogenital System / Q000382:microbiology
D000900:Anti-Bacterial Agents
Novyĭ podkhod k podboru antibakterial'nykh preparatov dlia lecheniia bol'nykh khronicheskimi urologicheskimi infektsiiami.