Perineuronal morphine: a comparison with epidural morphine.
In a double-blind, randomised controlled cross-over study the effects of perineuronal (perifemoral) injections of morphine were compared with epidural injections with the same amount of morphine in patients after knee surgery. Better pain scores were achieved during treatment with epidural morphine. We have not been able to confirm the hypothesis of neuro-axonal transport of morphine from the periphery to the spinal cord.
Dahl
J B
JB
Department of Anesthesia and Orthopaedic Surgery, Arhus County Hospital, Denmark.
Daugaard
J J
JJ
Kristoffersen
E
E
Johannsen
H V
HV
Dahl
J A
JA
D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005267:Femoral Nerve; D006801:Humans; D007268:Injections, Epidural; D007719:Knee Joint / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000627:therapeutic use; D009407:Nerve Block / Q000379:methods*; D010149:Postoperative Pain / Q000188:drug therapy / Q000628:therapy*; D011897:Random Allocation
D009020:Morphine