Age-dependent changes in GM1 and GD1a expression in mouse liver.
The ganglioside composition in the liver of SWR/J, A/J, and C57BL/10 (B10) mice was quantitatively analyzed at the ages of 2, 4, 6, 8, and 16 or 20 weeks by TLC-densitometric scanning. In all the strains, GM2, GM1, and GD1a were expressed at the age of 2 weeks. The contents of GM1 and GD1a in SWR/J, A/J, and B10 were 30, 10, and 1% at 4 weeks, and had decreased to 20, 5, and 0%, respectively, at 8 weeks. These results indicate that age-dependent changes in GM1 and GD1a expression occur in mouse liver, and that these three strains show different phenotypes as to this age-dependent expression.
Nakamura
Y
Y
Department of Membrane Biochemistry, Tokyo Metropolitan Institute of Medical Science.
Hashimoto
Y
Y
Yamakawa
T
T
Suzuki
A
A
D000375:Aging / Q000378:metabolism*; D000818:Animals; D005677:G(M1) Ganglioside / Q000235:genetics / Q000378:metabolism*; D005732:Gangliosides / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D008099:Liver / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D019158:N-Acetylneuraminic Acid; D010641:Phenotype; D012794:Sialic Acids / Q000378:metabolism
D005732:Gangliosides; D012794:Sialic Acids; C021298:ganglioside, GD1a; D005677:G(M1) Ganglioside; D019158:N-Acetylneuraminic Acid