Renal handling and mammary excretion of sulfatroxazole in goats.
The mechanisms involved in the renal handling and mammary excretion of sulfatroxazole (STZ) were studied in goats. Its excretion in urine was found to increase with increasing urine pH and was partly blocked by probenecid, indicating that renal handling of STZ involves glomerular filtration, active tubular secretion and passive reabsorption. The concentration of STZ in milk was lower than that in plasma and was found to increase with increasing milk pH. It was concluded that STZ is excreted in milk by passive diffusion of the nonionized nonprotein bound moiety.
Kinabo
L D
LD
Department of Pharmacology and Toxicology, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Nielsen
P
P
D000818:Animals; D005260:Female; D006041:Goats; D008892:Milk / Q000378:metabolism; D013420:Sulfamethoxazole / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000652:urine
D013420:Sulfamethoxazole; C048358:sulfatroxazole