High correlations of norepinephrine, dopamine, and epinephrine and their major metabolite excretion rates.
We have previously reported high correlations between norepinephrine and its metabolite outputs in depressed patients. In this article, we expand this finding to healthy volunteers and alcoholic patients. Furthermore, we find similar high correlations between urinary outputs of dopamine, norepinephrine, and their major metabolites. The same is true, to a lesser degree, for epinephrine and metanephrine outputs. There are implications of these findings for psychobiological research on the monoamine systems.
Linnoila
M
M
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892.
Oliver
J
J
Adinoff
B
B
Potter
W Z
WZ
D000328:Adult; D000437:Alcoholism / Q000652:urine; D002940:Circadian Rhythm; D003866:Depressive Disorder / Q000652:urine; D004298:Dopamine / Q000378:metabolism / Q000652:urine*; D004837:Epinephrine / Q000378:metabolism / Q000652:urine*; D005260:Female; D006719:Homovanillic Acid / Q000652:urine; D006801:Humans; D008297:Male; D008676:Metanephrine / Q000652:urine; D008734:Methoxyhydroxyphenylglycol / Q000652:urine; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism / Q000652:urine*; D014642:Vanilmandelic Acid / Q000652:urine
D008676:Metanephrine; D008734:Methoxyhydroxyphenylglycol; D014642:Vanilmandelic Acid; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid; D004837:Epinephrine