Hypertension in obese and non-obese non-insulin dependent diabetics a matter of regional adiposity?
There is growing evidence that differences in fat distribution can be predictive for differences in the prevalence of metabolic disturbances, cardio-vascular disease, stroke and death, independent of commonly used indices of obesity. This study evaluates regional body fat distribution as a possible main reason for hypertension in obese and non-obese type II diabetics. 42% of normal weight diabetics with abdominal obesity are hypertensive versus 47% of obese diabetics; only 5% hypertension could be found when a lower body segment fat distribution is present. A significant (p less than 0.001) correlation exists between fat mass topography and both systolic (r = 0.49) and diastolic (r = 0.49) blood pressure. This correlation remains true after correction for body mass index and percent glycosylated hemoglobin. These results suggest that localization of fat in the upper body segment should be considered as a additive risk for hypertension.
Van Gaal
L F
LF
Dept. Endocrinology, Metabolism and Nutrition, University of Antwerp Universiteitsplein, Wilrijk-Antwerp, Belgium.
Nobels
F R
FR
Rillaerts
E G
EG
Creten
W L
WL
De Leeuw
I H
IH
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000503:physiopathology*; D000328:Adult; D001794:Blood Pressure; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003971:Diastole; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009765:Obesity; D013599:Systole