Sodium dependent uptake of 3H-choline in the cerebral cortex of ageing male rats.
Uptake of 3H-choline and the binding of 3H-hemicholinium-3 in the cerebral cortex was investigated in male Wistar rats of different ages. The effect of Al3+-ions on 3H-choline uptake was also studied. Na-dependent high affinity uptake of 3H-choline and 3H-hemicholinium binding were lower in 10- to 11-month-old rats than in 3- to 4-month-old rats. There was no further decline in these parameters from 10- to 11-month-old to 24- to 25-month-old rats. Al3+-ions had no effect on the uptake of 3H-choline. The present study supports the hypothesis that there is a relationship between Na-dependent high affinity uptake of 3H-choline and the binding of 3H-hemicholinium in the crude synaptosomal fraction of the rat cerebral cortex.
Sirviö
J
J
Department of Neurology, University of Kuopio, Finland.
Hervonen
A
A
Riekkinen
P J
PJ
D000375:Aging / Q000378:metabolism*; D000535:Aluminum / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D002794:Choline / Q000378:metabolism*; D006426:Hemicholinium 3 / Q000378:metabolism; D008297:Male; D051381:Rats; D011921:Rats, Inbred WKY; D012964:Sodium / Q000502:physiology*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D006426:Hemicholinium 3; D012964:Sodium; D000535:Aluminum; D002794:Choline