title: Fosfomycin versus ampicillin in the treatment of acute pyelonephritis.
abstract: In a controlled open study of 38 patients with acute pyelonephritis, treatment with fosfomycin 8 g b.i.d. was compared to treatment with ampicillin 2 g t.i.d., both for one week. The most common pathogen in both groups was Escherichia coli, susceptible to fosfomycin. However, 17% were resistant to ampicillin. The success rate was 44% in the fosfomycin treated group and 28% in the ampicillin group. The difference was not significant (p greater than 0.20). Peak concentrations of fosfomycin in serum were 395 mg/l and in tissue fluid 85 mg/l. Urine concentrations ranged from 6990 to 24,320 mg/l.
authors.affiliation: Department of Infectious Diseases, University of Lund, Malmö General Hospital, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Ode
authors.forename: S
authors.initials: S
authors.lastname: Haidl
authors.forename: B
authors.initials: B
authors.lastname: Hoffstedt
authors.forename: M
authors.initials: M
authors.lastname: Walder
authors.forename: J
authors.initials: J
authors.lastname: Ursing
mesh_terms: D000208:Acute Disease; D000667:Ampicillin / Q000627:therapeutic use*; D005578:Fosfomycin / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D011704:Pyelonephritis / Q000188:drug therapy*; D011897:Random Allocation
chemical_list: D005578:Fosfomycin; D000667:Ampicillin