In vitro synergistic activity of ketoconazole with trifluoperazine and with chlorpromazine against medically important yeasts.
Combination of ketoconazole and trifluoperazine or chlorpromazine yielded an in vitro synergistic effect on growth inhibition of Candida albicans, Torulopsis glabrata, Cryptococcus neoformans, Candida parapsilosis and Candida tropicalis. The optimal pH range for the synergistic effects was 7.0-7.6. At pH 5.0 the drug combination was antagonistic. (Application for patent protection has been filed).
Ben-Gigi
G
G
Department of Bacteriology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Polacheck
I
I
Eilam
Y
Y
D002746:Chlorpromazine / Q000494:pharmacology*; D004336:Drug Antagonism; D004357:Drug Synergism; D006863:Hydrogen-Ion Concentration; D007654:Ketoconazole / Q000494:pharmacology*; D014268:Trifluoperazine / Q000494:pharmacology*; D015003:Yeasts / Q000187:drug effects*
D014268:Trifluoperazine; D007654:Ketoconazole; D002746:Chlorpromazine