title: The effect of YAG laser anterior capsulotomy on prostaglandin concentration in aqueous humor.
abstract: The YAG (yttrium aluminum garnet) laser has been recommended for anterior capsulotomies. One major complication is elevated intraocular pressure. We report a study of the biochemical content of the aqueous humor after a YAG laser anterior capsulotomy. We analyzed 6-keto-prostaglandin F1 alpha, thromboxane B2 and protein concentrations in the aqueous humor of human eyes. The average values of protein, 6-keto-prostaglandin F1 alpha, and thromboxane B2 in the control eyes were 81.3 +/- 14.0 mg/dL, 17 +/- 30 pg/mL, and 10 +/- 10 pg/mL, respectively. These values were elevated to 182.4 +/- 81.3 mg/dL, 401 +/- 55 pg/mL, and 576 +/- 148 pg/mL, respectively, after YAG laser anterior capsulotomy. The samples with a moderate level of 6-keto-prostaglandin F1 alpha (less than 300 pg/mL) had negligible changes of thromboxane. The elevation of thromboxane was obvious only when prostaglandin levels rose above 300 pg/mL.
authors.affiliation: Department of Ophthalmology, Memorial Hospital, Alton, Illinois.
authors.forename: T Y
authors.initials: TY
authors.lastname: Lin
authors.forename: M A
authors.initials: MA
authors.lastname: Siemens
authors.forename: K W
authors.initials: KW
authors.lastname: Lam
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism*; D001082:Aqueous Humor / Q000378:metabolism*; D006801:Humans; D053685:Laser Therapy; D007903:Lens Capsule, Crystalline / Q000601:surgery*; D007908:Lens, Crystalline / Q000601:surgery*; D009994:Osmolar Concentration; D011506:Proteins / Q000378:metabolism; D013929:Thromboxane B2 / Q000378:metabolism*
chemical_list: D011506:Proteins; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha