High-dose dexamethasone and high-dose metoclopramide versus high-dose dexamethasone and sulpiride in the management of cisplatin-induced emesis.
Twenty-eight courses of combination chemotherapy including cisplatin at the dose of 50 mg/m2 were analyzed in this antiemetic randomized double-blind study. The combination of high-dose dexamethasone and high-dose metoclopramide (regimen A) was compared with the combination of high-dose dexamethasone and sulpiride (regimen B). Regimen A was found to be more effective than regimen B when the mean score for intensity of vomiting was presented in only two categories. Four patients (14.3%) treated with regimen A suffered neither from nausea nor from vomiting. No serious side effects were observed.
Rosenblatt
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Northern Israel Oncology Center, Rambam Medical Center, Haifa.
Lev
L M
LM
Robinson
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E
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage; D010051:Ovarian Neoplasms / Q000188:drug therapy; D011897:Random Allocation; D013469:Sulpiride / Q000008:administration & dosage; D014839:Vomiting / Q000517:prevention & control*
D013469:Sulpiride; D003907:Dexamethasone; D008787:Metoclopramide; D002945:Cisplatin