Palmitate inhibits liver glycolysis. Involvement of fructose 2,6-bisphosphate in the glucose/fatty acid cycle.
In hepatocytes from overnight-fasted rats incubated with glucose, palmitate decreased the production of lactate, the detritiation of [2-3H]- and [3-3H]-glucose, and the concentration of fructose 2,6-bisphosphate. Similarly, perfusion of hearts from fed rats with beta-hydroxybutyrate resulted in an inhibition of the detritiation of [3-3H]glucose and a fall in fructose 2,6-bisphosphate concentration. This fall could result from an increase in citrate (hepatocytes and heart) and sn-glycerol 3-bisphosphate concentration. It is suggested that a fall in fructose 2,6-bisphosphate concentration participates in the inhibition of glycolysis by fatty acids and ketone bodies.
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Hormone and Metabolic Research Unit, Louvain University Medical School, Brussels, Belgium.
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D020155:3-Hydroxybutyric Acid; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D005635:Fructosediphosphates / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects*; D006321:Heart / Q000187:drug effects; D006598:Hexosediphosphates / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000494:pharmacology; D066298:In Vitro Techniques; D007657:Ketone Bodies / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D005227:Fatty Acids; D005635:Fructosediphosphates; D006598:Hexosediphosphates; D006885:Hydroxybutyrates; D007657:Ketone Bodies; D010169:Palmitic Acids; D019308:Palmitic Acid; C027652:fructose 2,6-diphosphate; D005947:Glucose; D020155:3-Hydroxybutyric Acid