Ultrastructure of human immunodeficiency virus type 2.
The ultrastructure of human immunodeficiency virus type 2 (HIV-2) was determined by negative stain and thin section electron microscopy (EM). Some virus particles had surface projections about 10 nm in length which were evenly spaced. Nonidet P40-treated particles which were penetrated by stain revealed a distinctive off-centre cone-shaped core and, in addition, free-lying cores were also seen in detergent-treated preparations. The surface of the cores was composed of a layer of small subunits. The structure of HIV-2 determined by thin section EM was the same as that deduced by negative stain EM.
Palmer
E
E
Division of Viral Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
Martin
M L
ML
Goldsmith
C
C
Switzer
W
W
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology; D000354:Africa, Western; D002460:Cell Line; D006678:HIV / Q000648:ultrastructure*; D006801:Humans; D008264:Macrophages / Q000382:microbiology; D008854:Microscopy, Electron