Bambuterol: clinical effects of different doses of a long-acting bronchodilator prodrug.
Sixty-eight asthmatics participated in a dose-finding study on bambuterol, a terbutaline prodrug, administered once every evening. Bambuterol administrations of 0.185, 0.270 and 0.400 mg/kg gave effective and long-lasting bronchodilation, for at least 24 h, with the two higher doses probably close to the maximal effect of the drug. Bambuterol 0.400 mg/kg was associated with more adverse effects than bambuterol 0.185 mg/kg. The side effects were those expected in oral beta 2-agonist treatment and mainly experienced by patients who had not been on oral beta 2-agonists before. The most favourable of the investigated doses was found to be 0.270 mg/kg. It can not be excluded, however, that a somewhat lower dose may still be as beneficial. This will be investigated in forthcoming studies.
Sandström
T
T
Department of Lung Medicine, University Hospital, Umeå, Sweden.
Asander
L
L
Clemmensen
I H
IH
Eklund
G
G
Gnosspelius
Y
Y
Klarlund Pedersen
B
B
Persson
G
G
Ravn
S
S
Rosenhall
L
L
Weeke
B
B
D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004358:Drug Therapy; D005260:Female; D005541:Forced Expiratory Volume; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011355:Prodrugs / Q000627:therapeutic use*; D013726:Terbutaline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use
D001993:Bronchodilator Agents; D011355:Prodrugs; D013726:Terbutaline; C047766:bambuterol