The suitability of a combined inulin/PAH retard tablet for measuring renal functions in the conscious rat.
As a further step in the development of implantable retard systems for simultaneous delivery of inulin and PAH, a system based on Eudragit matrix retard tablet has been deviced. It should be able to release a sufficient amount of both substances to maintain constant and well measurable serum and urine concentration in the 36 hours interval between 12-48 hours p.o. The feasibility of the technique was checked by monitoring the behaviour of renal function after administration of a permanent adrenaline application, which we used as a well defined noxa.
Sadjak
A
A
Universitätsinstitut für Funktionelle Pathologie, Karl-Franzens-Universität Graz, Austria.
Supanz
S
S
Korsatko
W
W
Erhart
U
U
Muhry
F
F
D000618:Aminohippuric Acids / Q000008:administration & dosage*; D000818:Animals; D003692:Delayed-Action Preparations; D005260:Female; D007444:Inulin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007677:Kidney Function Tests / Q000379:methods*; D008657:Metabolic Clearance Rate; D051381:Rats; D011919:Rats, Inbred Strains; D010130:p-Aminohippuric Acid / Q000008:administration & dosage* / Q000493:pharmacokinetics
D000618:Aminohippuric Acids; D003692:Delayed-Action Preparations; D007444:Inulin; D010130:p-Aminohippuric Acid