Regional brain concentrations of cholecystokinin in the rat: the effects of kindled and non-kindled seizures.
In an attempt to understand the neurochemical basis of kindling, this study investigated the effects on brain cholecystokinin (CCK) of amygdaloid kindled and non-kindled seizures. Thirteen brain regions were examined in rats sacrificed either 24 hr or 3 weeks after the last kindled seizure, or 24 hr after a suprathreshold stimulation-induced (non-kindled) seizure; and in sham kindled rats. There were no significant differences in CCK immunoreactivity between any of these groups. These results do not confirm a previous report of an increase in CCK in the hippocampus following amygdaloid kindling in the rat.
Harris
Q L
QL
University of Melbourne, Austin Hospital, Victoria, Australia.
Lewis
S J
SJ
Shulkes
A
A
Vajda
F J
FJ
Jarrott
B
B
D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D001923:Brain Chemistry / Q000187:drug effects*; D002766:Cholecystokinin / Q000378:metabolism*; D007696:Kindling, Neurologic; D008297:Male; D009929:Organ Size; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000378:metabolism*
D002766:Cholecystokinin