Effects of chronic flurazepam treatment on firing rate of rat substantia nigra pars reticulata neurons.
The effect of a benzodiazepine, flurazepam, on the spontaneous activity of neurons in the pars reticulata of the substantia nigra was studied in chloral hydrate anesthetized rats. Flurazepam produced a dose-related suppression of neuronal activity. In rats that were chronically treated with flurazepam, tolerance to flurazepam was present after 7 and 28 days, but not after only 3 days of treatment. Tolerance persisted at least 2, but not 7 days after 4 weeks of chronic treatment.
Tyma
J L
JL
Department of Pharmacology, Medical College of Ohio, Toledo 43699.
Rosenberg
H C
HC
Tietz
E I
EI
Chiu
T H
TH
D000200:Action Potentials / Q000187:drug effects; D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D005479:Flurazepam / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D005479:Flurazepam