Nonfluorescent dicentric Y in males with hypospadias.
We report three boys with severe hypospadias and bilaterally palpable testes with abnormalities of the Y chromosome detected by Q-banding. Severe hypospadias with palpable testes is an unusual presentation for Y chromosome abnormalities. Based on our experience, we recommend that boys with this phenotype undergo complete cytogenetic evaluation, because Y chromosome abnormalities prompt additional management concerns.
Drummond-Borg
M
M
Department of Medicine, University of Washington School of Medicine, Seattle.
Pagon
R A
RA
Bradley
C M
CM
Nordlund
J
J
Salk
D
D
D006801:Humans; D007021:Hypospadias / Q000235:genetics*; D007231:Infant, Newborn; D008297:Male; D010641:Phenotype; D012729:Sex Chromosome Aberrations; D014998:Y Chromosome