NMR measurement of the degree of oil/water partition of paramagnetic contrast media.
Magnetic resonance imaging techniques have been used to evaluate the oil/water partition of a series of stable nitroxide free radicals. The degree of partition, K, closely parallels the order of chemical polarity and lipophilicity of these compounds. This method also provides insight into both their nuclear magnetic resonance relaxation characteristics and pharmacokinetics.
Hall
L D
LD
Laboratory for Medicinal Chemistry, University of Cambridge, Clinical School, Addenbrooke's Hospital, United Kingdom.
Hogan
P G
PG
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003287:Contrast Media; D003497:Cyclic N-Oxides; D009682:Magnetic Resonance Spectroscopy; D013113:Spin Labels
D003287:Contrast Media; D003497:Cyclic N-Oxides; D013113:Spin Labels