title: Influence of tumor growth kinetics on response to doxorubicin treatment of C3H mammary carcinoma.
abstract: The influence of tumor growth kinetics on response to doxorubicin treatment of C3H mammary carcinoma was investigated. Gompertzian growth curves were obtained for the tumor mass of each mouse by a computerized best fit program. The response was assessed by evaluating: a) the total clonogenic cell reduction as a fraction of the initial tumor volume or the tumor volume that should result at the end of treatment in a free growth condition, and b) the partial clonogenic cell reduction at each drug administration, assuming a first order cell kill hypothesis. Slowly growing tumors at each dose level showed a significantly poorer response than rapidly growing tumors. Each response index exhibited a linear correlation with the specific instantaneous growth rate at the time of treatment. Data also suggested a dose-response dependence.
authors.affiliation: Divisione di Radioterapia e Oncologia USSL Legnago, Verona, Italia.
authors.forename: R
authors.initials: R
authors.lastname: Demicheli
authors.forename: R
authors.initials: R
authors.lastname: Foroni
authors.forename: F C
authors.initials: FC
authors.lastname: Giuliani
authors.forename: G
authors.initials: G
authors.lastname: Savi
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000188:drug therapy*; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000627:therapeutic use*; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy*; D051379:Mice; D008809:Mice, Inbred C3H
chemical_list: D004317:Doxorubicin