Response of the mouse femoral muscle to an implant of a composite of bone morphogenetic protein and plaster of Paris.
A composite consisting of 1 mg of bone morphogenetic protein (BMP) and 5 mg of plaster of Paris (PLP) was implanted into the mouse femoral muscle. Control PLP without BMP was implanted into the contralateral muscle. The BMP/PLP composite induced cartilage formation within two weeks, trabecular bone within three weeks, and lamellar bone including bone marrow within six weeks. PLP did not disturb BMP-induced bone formation. In addition, the BMP/PLP composite was resorbed early after implantation. These results suggest that PLP composite system is one of the most suitable BMP delivery systems currently available.
Yamazaki
Y
Y
First Department of Oral Surgery, Faculty of Dentistry, Tokyo Medical and Dental University, Japan.
Oida
S
S
Akimoto
Y
Y
Shioda
S
S
D000818:Animals; D019485:Bone Morphogenetic Proteins; D001842:Bone and Bones / Q000166:cytology / Q000000981:diagnostic imaging; D002133:Calcium Sulfate; D002356:Cartilage / Q000166:cytology / Q000000981:diagnostic imaging; D004343:Drug Implants; D006133:Growth Substances / Q000008:administration & dosage*; D051379:Mice; D009132:Muscles / Q000503:physiopathology; D010012:Osteogenesis; D011506:Proteins / Q000008:administration & dosage*; D011859:Radiography
D019485:Bone Morphogenetic Proteins; D004343:Drug Implants; D006133:Growth Substances; D011506:Proteins; D002133:Calcium Sulfate