Kinetic analysis of technetium-99m d,1-HM-PAO decomposition in aqueous media.
Technetium-99m-d,1-hexamethylpropyleneamine oxime [99mTc]d,1-HM-PAO) is a neutral-lipophilic chelate formed from a kit in high yield by stannous reduction of Na99mTcO4-. Of three methods used to analyze the purity of the 99mTc complexes, a single strip method using ether as the developing solvent was the most rapid and simple to perform. The lipophilic chelate converts to 99mTcO4- and other hydrophilic products with time and this limits the useful lifetime of the preparations. The rate of decomposition of [99mTc]d,1-HM-PAO increased in the presence of excess stannous ion and at pH greater than 9.
Hung
J C
JC
Department of Radiology, University of Missouri-Columbia.
Corlija
M
M
Volkert
W A
WA
Holmes
R A
RA
D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D009942:Organometallic Compounds; D010091:Oximes; D011934:Reagent Strips; D013667:Technetium; D019690:Technetium Tc 99m Exametazime; D014867:Water
D009942:Organometallic Compounds; D010091:Oximes; D011934:Reagent Strips; D014867:Water; D019690:Technetium Tc 99m Exametazime; D013667:Technetium