Large microtubule-associated protein of T. brucei has tandemly repeated, near-identical sequences.
The parasitic protozoon Trypanosoma brucei contains a highly organized membrane skeleton, consisting of a dense array of parallel, singlet microtubules that are laterally interconnected and that are also in tight contact with the overlying cell membrane. A high molecular weight, heat-stable protein from this membrane skeleton was isolated that is localized along the microtubules. Protease digestion experiments and sequencing of a cloned gene segment showed that most of the protein is built up by more than 50 nearly identical tandem repeats with a periodicity of 38 amino acids.
Schneider
A
A
Institut für allgemeine Mikrobiologie, Universität Bern, Switzerland.
Hemphill
A
A
Wyler
T
T
Seebeck
T
T
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002451:Cell Compartmentation; D002462:Cell Membrane / Q000648:ultrastructure; D003001:Cloning, Molecular; D008854:Microscopy, Electron; D008869:Microtubule-Associated Proteins / Q000032:analysis* / Q000235:genetics; D008870:Microtubules / Q000648:ultrastructure; D008969:Molecular Sequence Data; D008970:Molecular Weight; D012091:Repetitive Sequences, Nucleic Acid; D014346:Trypanosoma brucei brucei / Q000032:analysis* / Q000235:genetics / Q000648:ultrastructure
D008869:Microtubule-Associated Proteins