title: Amplification of c-myc and pvt-1 homologous sequences in acute nonlymphatic leukemia.
abstract: Leukemic cells with double minute (DM) chromosomes from an ANLL(M1) patient were found to carry 10-15 fold amplified c-myc sequences. The linked pvt-1-like locus was amplified at the same level, suggesting that the c-myc amplicon is at least 300 kb in size.
authors.affiliation: Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Asker
authors.forename: C
authors.initials: C
authors.lastname: Mareni
authors.forename: D
authors.initials: D
authors.lastname: Coviello
authors.forename: S
authors.initials: S
authors.lastname: Ingvarsson
authors.forename: M
authors.initials: M
authors.lastname: Sessarego
authors.forename: P
authors.initials: P
authors.lastname: Origone
authors.forename: G
authors.initials: G
authors.lastname: Klein
authors.forename: J
authors.initials: J
authors.lastname: Sumeigi
mesh_terms: D000208:Acute Disease; D001483:Base Sequence; D005784:Gene Amplification; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011519:Proto-Oncogenes; D012689:Sequence Homology, Nucleic Acid