A genetical model for vitiligo.
A genetical model is found to provide a good fit to family data on vitiligo. The model postulates that recessive alleles at a set of four unlinked diallelic loci are involved in the causation of the disorder. Under this multiple recessive homozygosis model, for normal X affected families ascertained through the affected parent, the expected segregation probability is .063; the estimated value is 0.53, which is not significantly different from the expected value. For normal X normal families ascertained through an affected offspring, the expected segregation probability is .037; the estimated value is .04.
Majumder
P P
PP
Department of Biostatistics, University of Pittsburgh, PA 15261.
Das
S K
SK
Li
C C
CC
D000367:Age Factors; D000483:Alleles; D005787:Gene Frequency; D005808:Genes, Recessive; D006720:Homozygote; D006801:Humans; D008957:Models, Genetic; D011336:Probability; D014820:Vitiligo / Q000235:genetics*