title: Hemoglobin spherulosis in the vitreous cavity.
abstract: A 50-year-old woman was evaluated for a subretinal hemorrhage that extended into the vitreous of the right eye. Examination showed multiple refractile brown spherules in the vitreous. A vitrectomy was performed, and pathologic examination of the spherules showed them to be composed of free hemoglobin. Free-hemoglobin spherulosis in the vitreous, like cholesterosis bulbi, is a manifestation of vitreous hemorrhage.
authors.affiliation: Department of Pathology, University Hospital of Cleveland, Case Western Reserve University, OH.
authors.forename: H E
authors.initials: HE
authors.lastname: Grossniklaus
authors.forename: K E
authors.initials: KE
authors.lastname: Frank
authors.forename: D C
authors.initials: DC
authors.lastname: Farhi
authors.forename: G
authors.initials: G
authors.lastname: Jacobs
authors.forename: W R
authors.initials: WR
authors.lastname: Green
mesh_terms: D005128:Eye Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D012166:Retinal Hemorrhage / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D014822:Vitreous Body / Q000378:metabolism* / Q000473:pathology
chemical_list: D006454:Hemoglobins