title: Stimulation of gastric acid secretion by microinjection of pentobarbital into the ventromedial hypothalamus.
abstract: Sites of stimulatory action of pentobarbital on gastric acid secretion were studied in rats anesthetized with urethane. Intracerebroventricular injection of pentobarbital dose-dependently stimulated gastric secretion. When injections of pentobarbital into the ventromedial hypothalamus were repeated with an interval of 30 min, the second and third consecutive injections produced a small but significant increase in gastric acid secretion. We propose that the ventromedial hypothalamus is involved in the stimulatory effect of pentobarbital on gastric acid secretion.
authors.affiliation: Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Japan.
authors.forename: W C
authors.initials: WC
authors.lastname: Lin
authors.forename: S
authors.initials: S
authors.lastname: Yano
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D007033:Hypothalamus, Middle / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D008845:Microinjections; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010424:Pentobarbital