A chromosome with five gamma-globin genes.
Globin gene mapping of DNA from a Black newborn resulted in the detection of a chromosome with five gamma-globin genes. Based on results from digests with enzymes EcoRI and PstI, we concluded that the three genes between the 5'G gamma and 3'A gamma genes are G gamma genes with a possible 5' segment derived from A gamma. The high G gamma level in the fetal hemoglobin (Hb F) of the baby is consistent with this view. Family relationships were such that speculation as to the mechanism causing this quintuplication of the gamma-globin genes was not possible.
Fei
Y J
YJ
Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912-2100.
Lanclos
K D
KD
Kutlar
F
F
Walker
E L
EL
Huisman
T H
TH
D004247:DNA / Q000032:analysis; D005914:Globins / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D005810:Multigene Family
D005914:Globins; D004247:DNA