[Studies on tissue PO2 and biochemical analysis of the skeletal muscle of legs with chronic arterial occlusive diseases].
Measurements of maximum tissue PO2 during 100% O2 inhalation (PtO2max) and biochemical analysis of the skeletal muscle were performed in 3 legs without ischemia and 14 legs with chronic arterial occlusive disease requiring amputation. There were significant good correlations between PtO2max and levels of pH, lactate, enzymes (CPK, LDH, Aldolase) and ATP in the skeletal muscle with ischemia. In regions in which PtO2max was below 10mmHg, ischemic changes in the muscle were considered to be irreversible. On the contrary, primary wound healing was obtained in regions with 40mmHg or more of PtO2max. Measurements of the PtO2max of the ischemic muscles provided much useful information concerning the reversibility of muscle ischemia and for decision of the amputation level.
Yamamoto
T
T
Department of Surgery, Kawasaki Medical School, Kurashiki, Japan.
Fujiwara
T
T
Dokoh
S
S
Inada
H
H
Masaki
H
H
Katsumura
T
T
Ichihara
K
K
D000255:Adenosine Triphosphate / Q000378:metabolism; D001157:Arterial Occlusive Diseases / Q000378:metabolism*; D003402:Creatine Kinase / Q000378:metabolism; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D007866:Leg / Q000098:blood supply* / Q000601:surgery; D009132:Muscles / Q000378:metabolism*; D010100:Oxygen / Q000032:analysis*; D010313:Partial Pressure
D007773:Lactates; D000255:Adenosine Triphosphate; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase; D010100:Oxygen