title: Increased production of malondialdehyde in patients with HIV infection.
abstract: The mean plasma content of malondialdehyde (MDA) in 30 patients in different stages of HIV infection was found to be about 30% higher than that in controls. The phenomenon was not correlated to the degree of immunodeficiency and was noted early in the course of the disease. This indicates a higher degree of basal lipid peroxidation, which might contribute to the tissue damage seen in these patients. A new reverse phase liquid chromatography method was used for quantitative measurements of MDA in plasma after reaction of this compound with thiobarbituric acid.
authors.affiliation: Department of Infectious Diseases, Roslagstull Hospital, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Sönnerborg
authors.forename: G
authors.initials: G
authors.lastname: Carlin
authors.forename: B
authors.initials: B
authors.lastname: Akerlund
authors.forename: C
authors.initials: C
authors.lastname: Jarstrand
mesh_terms: D000386:AIDS-Related Complex / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005609:Free Radicals; D006679:HIV Seropositivity / Q000097:blood*; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008314:Malonates / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood* / Q000378:metabolism; D013858:Thiobarbiturates
chemical_list: D005609:Free Radicals; D008054:Lipid Peroxides; D008314:Malonates; D013858:Thiobarbiturates; D008315:Malondialdehyde; C029684:thiobarbituric acid