title: Synthetic magainin analogues with improved antimicrobial activity.
abstract: Based on modifications to enhance the alpha-helical structure of the broad spectrum antibiotic magainin 2, a series of analogues have been synthesized which display an increase up to two orders of magnitude in antimicrobial activity and, in the most favorable case, no appreciable increase in hemolytic activity over magainin 1 at the concentrations tested.
authors.affiliation: Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892.
authors.forename: H C
authors.initials: HC
authors.lastname: Chen
authors.forename: J H
authors.initials: JH
authors.lastname: Brown
authors.forename: J L
authors.initials: JL
authors.lastname: Morell
authors.forename: C M
authors.initials: CM
authors.lastname: Huang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D002942:Circular Dichroism; D054806:Magainins; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D029867:Xenopus Proteins; D014982:Xenopus laevis
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D054806:Magainins; D010455:Peptides; D029867:Xenopus Proteins; C053301:magainin 2 peptide, Xenopus; C053300:magainin 1 peptide, Xenopus