title: Testicular effects of acrylonitrile in mice.
abstract: Daily oral administration of acrylonitrile (10 mg/kg body weight) to mice for a period of 60 days caused a significant decrease in the activity of testicular sorbitol dehydrogenase and acid phosphatase, and an increase in that of lactate dehydrogenase and beta-glucuronidase. Histopathological studies revealed degeneration of the seminiferous tubules. A decrease in the sperm counts of the epididymal spermatozoa was also observed in the animals of the acrylonitrile-exposed group. These observations suggest that acrylonitrile may affect the male reproductive function by causing testicular injury.
authors.affiliation: Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
authors.forename: R
authors.initials: R
authors.lastname: Tandon
authors.forename: D K
authors.initials: DK
authors.lastname: Saxena
authors.forename: S V
authors.initials: SV
authors.lastname: Chandra
authors.forename: P K
authors.initials: PK
authors.lastname: Seth
authors.forename: S P
authors.initials: SP
authors.lastname: Srivastava
mesh_terms: D000135:Acid Phosphatase / Q000037:antagonists & inhibitors; D000181:Acrylonitrile / Q000633:toxicity*; D000818:Animals; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D007064:L-Iditol 2-Dehydrogenase / Q000037:antagonists & inhibitors; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D051379:Mice; D009570:Nitriles / Q000633:toxicity*; D012671:Seminiferous Tubules / Q000187:drug effects / Q000473:pathology; D013076:Sperm Count / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology
chemical_list: D009570:Nitriles; D007064:L-Iditol 2-Dehydrogenase; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D000135:Acid Phosphatase; D005966:Glucuronidase; D000181:Acrylonitrile