title: Agonal elevation in serum digoxin concentrations in infants and children long after cessation of therapy.
abstract: In 11 of 15 profoundly sick, digitalized infants and children, elevation in serum digoxin concentration could be detected long after cessation of therapy. This phenomenon concurred with a rapid deterioration of renal function. Because death of a digitalized child may be attributed to the glycoside itself, it is important to recognize that elevation in serum concentration to a potentially toxic level is a common pathophysiologic pattern.
authors.affiliation: Division of Clinical Pharmacology, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Koren
authors.forename: D
authors.initials: D
authors.lastname: Beatie
authors.forename: S
authors.initials: S
authors.lastname: Soldin
mesh_terms: D002648:Child; D002675:Child, Preschool; D004077:Digoxin / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006330:Heart Defects, Congenital / Q000188:drug therapy*; D006463:Hemolytic-Uremic Syndrome / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000139:chemically induced / Q000378:metabolism; D008297:Male; D011446:Prospective Studies
chemical_list: D004077:Digoxin