Dose-response relationship between light irradiance and the suppression of plasma melatonin in human volunteers.
This study tested the capacity of different irradiances of monochromatic light to reduce plasma melatonin in normal humans. Six healthy male volunteers, 24-34 years old, were exposed to 0.01, 0.3, 1.6, 5, or 13 microW/cm2 of 509 nm monochromatic light for 1 h during the night on separate occasions. Light irradiance depressed plasma melatonin in a dose-response pattern. The data indicate that the mean threshold irradiance for suppressing melatonin is between 1.6 and 5 microW/cm2. Individual variations in threshold responses to monochromatic light were observed among the volunteers.
Brainard
G C
GC
Department of Neurology, Jefferson Medical College, Philadelphia, PA 19107.
Lewy
A J
AJ
Menaker
M
M
Fredrickson
R H
RH
Miller
L S
LS
Weleber
R G
RG
Cassone
V
V
Hudson
D
D
D000328:Adult; D006801:Humans; D008029:Lighting; D008297:Male; D008550:Melatonin / Q000097:blood*; D010870:Pineal Gland / Q000378:metabolism / Q000502:physiology*
D008550:Melatonin