RED1: a yeast gene required for the segregation of chromosomes during the reductional division of meiosis.
A mutation at the RED1 locus was identified in a search for sporulation-proficient, meiotic-lethal yeast mutants. The few viable spores produced in the red1-1 mutant are highly aneuploid, suggesting that the spore lethality results from a high frequency of chromosome nondisjunction. Disomic spores produced by the red1-1 mutant contain nonsister chromatids and the red1-1 spore inviability phenotype is alleviated in red1-1 spo13 double mutants; these results indicate that nondisjunction occurs at the first meiotic division. The red1-1 mutant is recombination-proficient. The RED1 gene was cloned by complementation of the meiotic lethal phenotype; strains carrying a disruption of the gene are mitotically viable. We propose that the RED1 gene product is involved in meiosis I chromosome disjunction, perhaps by maintaining the connections between homologous chromosomes through metaphase I.
Rockmill
B
B
Department of Biology, Yale University, New Haven, CT 06511.
Roeder
G S
GS
D000782:Aneuploidy; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D005800:Genes, Fungal; D008540:Meiosis; D009154:Mutation; D010641:Phenotype; D015003:Yeasts / Q000235:genetics*