S-adenosylhomocysteine metabolism in Streptomyces flocculus.
S-Adenosylhomocysteine metabolism was studied in cell extracts of streptonigrin-producing Streptomyces flocculus. The major route of metabolism was found to be deamination to form S-inosylhomocysteine. The metabolite was purified by high-performance liquid chromatography and identified by its UV and nuclear magnetic resonance spectra and by its chemical degradation to hypoxanthine.
Speedie
M K
MK
Department of Medicinal Chemistry/Pharmacognosy, School of Pharmacy, University of Maryland, Baltimore 21201.
Zulty
J J
JJ
Brothers
P
P
D002851:Chromatography, High Pressure Liquid; D006710:Homocysteine / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D007288:Inosine / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D012435:S-Adenosylhomocysteine / Q000302:isolation & purification / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism*
D006710:Homocysteine; C057008:S-inosylhomocysteine; D007288:Inosine; D012435:S-Adenosylhomocysteine