Recombination within the class III region by a double cross over event.
Analysis of class I, class II, and class III gene products of the human MHC in a Caucasoid family with four children gave evidence for a double crossing over event in monozygotic twins between the C2, Bf/C4A, C4B gene loci. In view of the small genetic distance between C2 and C4, a point mutation within the Bf locus must be considered alternatively.
Rose
M
M
Institute of Forensic Medicine, School of Medicine (Charité), Humboldt University, Berlin, GDR.
Menzel
G R
GR
Geserick
G
G
Doxiadis
G
G
Grosse-Wilde
H
H
Mukaida
M
M
Rackwitz
A
A
D003434:Crossing Over, Genetic; D005260:Female; D006680:HLA Antigens / Q000145:classification; D006801:Humans; D008285:Major Histocompatibility Complex; D008297:Male; D009154:Mutation; D011995:Recombination, Genetic
D006680:HLA Antigens