title: Preventing, delaying, and repairing photoaged skin.
abstract: The characteristics of chronologically aged skin should be differentiated from the features of photoaging, which is marked by yellowed, leathery, sagging, wrinkled, elastic skin, as well as underlying connective tissue damage and various benign, premalignant, and malignant neoplasms. Laboratory experiments with the hairless mouse exposed to varying doses of ultraviolet radiation have demonstrated the protective effects of sunscreens, the repair of ultraviolet damage when the skin is no longer bombarded by photons, and the enhancement of that repair by retinoids.
authors.affiliation: Department of Dermatology, School of Medicine, University of Pennsylvania, Philadelphia 19104.
authors.forename: L H
authors.initials: LH
authors.lastname: Kligman
mesh_terms: D000375:Aging; D000818:Animals; D006801:Humans; D051379:Mice; D008812:Mice, Hairless; D012867:Skin / Q000473:pathology / Q000528:radiation effects*; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D013472:Sunlight / Q000009:adverse effects*; D013473:Sunscreening Agents / Q000627:therapeutic use*; D014212:Tretinoin / Q000627:therapeutic use*; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D013473:Sunscreening Agents; D014212:Tretinoin