Erythropoietic protoporphyria exacerbated by oral iron therapy.
Four patients with erythropoietic protoporphyria (EPP) are reported, in whom oral iron produced clear-cut clinical and biochemical deterioration. This suggests that there are two biochemically and genetically distinct sub-groups of EPP patients distinguished by their dramatically different response to oral iron.
Milligan
A
A
Department of Dermatology, Leicester Royal Infirmary, London, U.K.
Graham-Brown
R A
RA
Sarkany
I
I
Baker
H
H
D000328:Adult; D000747:Anemia, Hypochromic / Q000188:drug therapy / Q000209:etiology; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007501:Iron / Q000009:adverse effects* / Q000097:blood; D010787:Photosensitivity Disorders / Q000097:blood / Q000139:chemically induced*; D011164:Porphyrias / Q000150:complications; D011524:Protoporphyrins / Q000097:blood; D012871:Skin Diseases / Q000150:complications
D011524:Protoporphyrins; D005293:Ferritins; D007501:Iron