title: Absence of pulmonary edema during peritonitis and shock in rats.
abstract: We evaluated the development of pulmonary edema early in the course of peritonitis and shock in rats. Peritonitis was established by cecal ligation and perforation. In a preliminary experiment, sepsis was induced in five animals and five animals served as sham-operated controls. Lungs harvested for gravimetric analysis at 6 hours revealed no significant difference in wet-dry/dry (W-D/D) ratios. In a second experiment, 15 rats were randomized to three groups: septic animals, septic animals infused with 5% albumin, and sham-operated animals. Thermodilution cardiac output and arterial blood gases were sequentially measured over a 6-hour interval. At 6 hours, the lungs were harvested for gravimetric analysis. Lung W-D/D and arterial oxygenation were not significantly different between the three groups. The W-D/D was 3.46 +/- 0.10 in sham-operated rats, 3.37 +/- 0.12 in septic rats, and 3.88 +/- 0.27 in albumin-infused septic rats. The alveolar-arterial oxygen difference at 6 hours was 10 +/- 2 mm Hg in sham-operated rats, 7 +/- 1 mm Hg in septic rats, and 13 +/- 6 mm Hg in albumin-infused septic rats. These data suggest that overt pulmonary edema and arterial hypoxemia may not occur early in septic shock when fluid infusion is not excessive.
authors.affiliation: Department of Medicine, University of Health Sciences, Chicago Medical School, IL 60064.
authors.forename: E C
authors.initials: EC
authors.lastname: Rackow
authors.forename: M E
authors.initials: ME
authors.lastname: Astiz
authors.forename: T G
authors.initials: TG
authors.lastname: Janz
authors.forename: M W
authors.initials: MW
authors.lastname: Weil
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure; D002302:Cardiac Output; D005110:Extracellular Space / Q000378:metabolism; D006339:Heart Rate; D007773:Lactates / Q000097:blood; D008168:Lung / Q000378:metabolism; D010538:Peritonitis / Q000150:complications* / Q000503:physiopathology; D011654:Pulmonary Edema / Q000209:etiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration; D012772:Shock, Septic / Q000150:complications* / Q000503:physiopathology
chemical_list: D007773:Lactates