title: Tricyclic antidepressant binding to lymphocyte membranes and changes during depression.
abstract: The binding of [3H]imipramine, its 2- and 4-nitroderivatives and [3H]desmethylimipramine to lymphocyte membranes was determined. IC50 values for drugs and neurotransmitters to inhibit [3H]imipramine binding to lymphocyte membranes were comparable with those for brain and thrombocyte membranes. The number of [3H]imipramine and [3H]desmethylimipramine binding sites increased in depressive patients, whereas the dissociation constants remained unchanged.
authors.affiliation: Psychiatric Research Unit, Faculty of Medicine, Charles University, Prague, Czechoslovakia.
authors.forename: R
authors.initials: R
authors.lastname: Krulík
authors.forename: D
authors.initials: D
authors.lastname: Slíva
authors.forename: J
authors.initials: J
authors.lastname: Sikora
authors.forename: I
authors.initials: I
authors.lastname: Farská
authors.forename: K
authors.initials: K
authors.lastname: Fuksová
mesh_terms: D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003866:Depressive Disorder / Q000378:metabolism*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D000929:Antidepressive Agents, Tricyclic