Rapid measurement of dialyzer clearance as a function of molecular weight.
The relationship between solute clearance and molecular weight (MW) is an important performance characteristic of hemodialyzers. Traditionally, this relationship has been determined using a range of solutes of diverse properties that require a variety of analytical procedures. We describe a simple method for obtaining clearance as a function of MW using a homologous series of glucose oligomers, continuous from the monomer to the octamer. Using HPLC, single analyses of the inflow and outflow streams of the dialyzer allow the determination of clearances over a MW range of up to 1314 daltons.
Klein
E
E
Division of Nephrology, School of Medicine, University of Louisville, Kentucky.
Turnham
T J
TJ
Ward
R A
RA
D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D005947:Glucose / Q000032:analysis; D008970:Molecular Weight; D012044:Regression Analysis; D006435:Renal Dialysis
D005947:Glucose