title: [Immunomodulating properties of khlotazol].
abstract: A nonsteroidal anti-inflammatory agent khlotazol administered to rats in doses of 40-80 mg/kg for 5 days stimulated synthesis of IgM- and IgG-antibodies to ram erythrocytes and increased the number of antibody-forming cells (AFC) and rosette-forming cells (RFC) in the spleen. When the doses were increased to 160-320 mg/kg, the stimulating effect of the drug on the production of hemagglutinins retained but dose-dependent inhibition of the number of AFC and RFC was found. When administered in a dose of 80 mg/kg khlotazol markedly activated the reaction of hypersensitivity of delayed type induced by ram erythrocytes.
authors.forename: D N
authors.initials: DN
authors.lastname: Evnin
authors.forename: Ia I
authors.initials: IaI
authors.lastname: Khadzhaĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Novikov
authors.forename: G T
authors.initials: GT
authors.lastname: Klykova
authors.forename: M V
authors.initials: MV
authors.lastname: Kedrovskaia
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D002697:Chloral Hydrate / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012397:Rosette Formation; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013844:Thiazoles; D002697:Chloral Hydrate; C034140:chlotazol
vernacular_title: Immunomoduliruiushchie svoĭstva khlotazola.