Effect of immobilization stress on tricyclic antidepressant binding and serotonin uptake in rats.
Immobilization stress increased the density of imipramine binding sites in platelet and cortical membranes and there was an increased serotonin uptake in platelets. There was a decrease in desipramine binding and noradrenaline uptake in lymphocytes. Our results show that stress acts on the mediator systems in various ways.
Farská
I
I
Psychiatric Research Unit, Faculty of Medicine, Charles University, Praha, Czechoslovakia.
Krulík
R
R
Slíva
D
D
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003891:Desipramine / Q000378:metabolism; D004082:Dihydroalprenolol; D007099:Imipramine / Q000378:metabolism; D007700:Kinetics; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism*
D000929:Antidepressive Agents, Tricyclic; D012701:Serotonin; D004082:Dihydroalprenolol; D007099:Imipramine; D003891:Desipramine; D009638:Norepinephrine