Biological significance of HLA-A,B,C expression in neuroblastoma and related cell lines.
In these studies, strong HLA-A,B,C or b2-m expression was not detected in any stage of development of normal neurons. These included regenerating cells of the olfactory epithelium, developing neural tissue in the mouse embryo, and normal adult brain. Nor was an obligatory role for HLA-A,B,C or b2-m revealed by in vitro analysis of a growing neuroblastoma cell line.
Lampson
L A
LA
Children's Cancer Research Center, Children's Hospital of Philadelphia, PA 19104.
D000818:Animals; D002460:Cell Line; D006680:HLA Antigens / Q000378:metabolism*; D006801:Humans; D051379:Mice; D009416:Nerve Regeneration; D009447:Neuroblastoma / Q000276:immunology*; D009474:Neurons / Q000196:embryology / Q000276:immunology* / Q000502:physiology
D006680:HLA Antigens