title: Twelve-year experience with chemotherapy in adult metastatic renal cell carcinoma at the Institut Gustave-Roussy.
abstract: One hundred fifty-three adult patients with metastatic renal carcinoma were treated over a 12-year period. Five successive chemotherapeutic protocols were used: vincristine or teniposide plus CCNU, elliptinium weekly or monthly, ifosfamide, and lastly, a multidrug regimen with adriamycin, vindesine, cyclophosphamide, cisplatinum, and dacarbazine. Results obtained with these different consecutive protocols were very disappointing with only ten (7%) objective responses encountered.
authors.affiliation: Medical Department, Institut Gustave-Roussy, Villejuif, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Droz
authors.forename: C
authors.initials: C
authors.lastname: Theodore
authors.forename: M
authors.initials: M
authors.lastname: Ghosn
authors.forename: H
authors.initials: H
authors.lastname: Lupera
authors.forename: G
authors.initials: G
authors.lastname: Piot
authors.forename: A
authors.initials: A
authors.lastname: De Forges
authors.forename: M
authors.initials: M
authors.lastname: Klink
authors.forename: J
authors.initials: J
authors.lastname: Rouesse
authors.forename: J L
authors.initials: JL
authors.lastname: Amiel
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000188:drug therapy / Q000556:secondary*; D004611:Ellipticines / Q000627:therapeutic use; D005260:Female; D005602:France; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D004611:Ellipticines; C027767:elliptinium; D007069:Ifosfamide