[Modelling and simulation of urea balance in a rat model on the condition of large intestine infusion analogous to the ultrafiltrate as a contribution to the development of an implantable intestinal hybrid kidney].
The urea kinetics in blood plasma is discussed for the animal model in rats in the development conception of an implantable artificial kidney, in which the filtration process is received energetically endogenically by a technical hemofilter whereas the ultrafiltrate procedure takes place by intestinal reabsorption and elimination of the end-products. The underlying monocompartment model contains the elements plasma, hemofilter, intestine including their urea turnover rates. Further on a special model conception is developed for the animal experimental designation of the selective urea reflecting power of the intestinal mucosa. The hemofilter-intestine-hybrid kidney-system has chanced to be in order if the experimentally ascertained quantities of the preliminary experiments will be inserted simultaneously for essential parameters in the model experiment.
Schumann
L
L
Abteilung Pathophysiologie, Wilhelm-Pieck-Universität Rostock.
Dörp
E
E
Wüstenberg
P W
PW
Schröder
J
J
Falkenhagen
D
D
Klinkmann
H
H
D000818:Animals; D006440:Hemofiltration; D007420:Intestine, Large / Q000502:physiology*; D007688:Kidneys, Artificial; D007700:Kinetics; D008954:Models, Biological; D019736:Prostheses and Implants; D051381:Rats; D014508:Urea / Q000378:metabolism*
D014508:Urea
Modellierung und Simulierung des Harnstoffhaushaltes im Rattentiermodell unter den Bedingungen der ultrafiltratanalogen Dickdarminfusion als Beitrag zur Entwicklung einer implantierbaren Darmhybridniere.