Area postrema ablation and vascular reactivity in deoxycorticosterone-salt-treated rats.
In rats, central administration of the neurotoxin 6-hydroxydopamine prevents hypertension and certain functional vascular changes after deoxycorticosterone (DOC)-salt treatment. In this study, the effect of electrolytic ablation of the area postrema on blood pressure and vascular reactivity in DOC-salt-treated rats was examined. Four treatment groups of rats were studied (n = 5 in each): area postrema lesion, DOC-salt (DOC pivalate, 5 mg/wk s.c. for 5 weeks); sham lesion, DOC-salt; area postrema lesion, control; and sham lesion, control. Helically cut strips of carotid artery, aorta, and mesenteric artery were prepared for isometric force recording. Area postrema lesion attenuated hypertension in DOC-salt rats (mean arterial pressure, 107 vs 123 mm Hg in area postrema lesion and sham lesion rats, respectively; chronic aortic catheter). Vascular strips from sham lesion-control rats. These changes in vascular reactivity also were observed in area postrema lesion-DOC-salt rats. DOC treatment in rats on a normal sodium intake did not result in hypertension or increased vascular reactivity. In summary, integrity of the area postrema is necessary for hypertension but not for changes in vascular reactivity, in DOC-salt rats. It appears that 1) changes in vascular reactivity may be necessary, but they are not sufficient to produce DOC-salt hypertension, and 2) if these vascular changes are secondary to a central nervous system effect, they are mediated by a pathway distinct from the area postrema.
Bruner
C A
CA
Department of Physiology, University of Michigan, Ann Arbor 48109-0622.
Mangiapane
M L
ML
Fink
G D
GD
Webb
R C
RC
D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone / Q000494:pharmacology / Q000633:toxicity*; D004357:Drug Synergism; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology* / Q000601:surgery; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000503:physiopathology; D010042:Ouabain / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology / Q000633:toxicity*; D014661:Vasoconstriction / Q000187:drug effects*
D012701:Serotonin; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D010042:Ouabain; D011189:Potassium Chloride