[Tumor development and monooxygenase activity in the liver of mice exposed to the combined action of N-nitrosodimethylamine and benz(a)pyrene].
The combined administration to mice of N-nitrosodimethylamine (NDMA) in drinking water and of benz(a)pyrene (BP) in skin applications induces mainly skin tumours and the use of BP in food--stomach tumours. The skin application of BP prevents the development of tumours after NDMA administration. The combined action of these carcinogens reduces the latent period of tumour incidence, lowers the induction of BP-hydroxylase and the activity of N-demethylase of NDMA.
Rubenchik
B L
BL
Iukhimenko
M D
MD
Boĭm
T M
TM
Mikhaĭlenko
V M
VM
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D001579:Benzopyrene Hydroxylase / Q000096:biosynthesis; D019392:Cytochrome P-450 CYP2E1; D004128:Dimethylnitrosamine / Q000633:toxicity*; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000201:enzymology; D010089:Oxidoreductases, N-Demethylating / Q000096:biosynthesis; D010105:Oxygenases / Q000378:metabolism*
D001564:Benzo(a)pyrene; D010105:Oxygenases; D019392:Cytochrome P-450 CYP2E1; D001579:Benzopyrene Hydroxylase; D010089:Oxidoreductases, N-Demethylating; D004128:Dimethylnitrosamine
Razvitie opukholeĭ i aktivnost' monooksigenaz pecheni u mysheĭ pri kombinirovannom deĭstvii N-nitrozodimetilamina i benz(a)pirena.