title: [Effect of methotrexate on the early stages of immunogenesis in mice].
abstract: The data of the study on the effect of a single intraperitoneal administration of methotrexate (0.5 mg/kg) on the early stages of immunogenesis of mice are presented. A single administration of the drug in different periods before immunization (1-10 days) was shown to induce no suppression of the immune response. On the contrary, at the administration of methotrexate 6-9 days before antigen administration a distinct stimulating effect was noted (320-350% of the control level). The administration of the drug daily for 6 days produced no, significant changes in the immune response formation and only 7-8-day administrations led to a significant decrease of the immune response (24-50% of the control level). The results obtained suggest that the time of renewal of the population of immunocompetent cells in the mouse spleen is 6-9 days.
authors.forename: N B
authors.initials: NB
authors.lastname: Dmitrieva
authors.forename: B S
authors.initials: BS
authors.lastname: Uteshev
mesh_terms: D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D007114:Immunization; D007121:Immunocompetence / Q000187:drug effects; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
chemical_list: D007075:Immunoglobulin M; D008727:Methotrexate
vernacular_title: Vliianie metotreksata na rannie étapy immunogeneza u mysheĭ.