Effects of a-fluoromethylhistidine on sleep and wakefulness in the rat. Short note.
The histamine synthesis inhibitor a-fluoromethylhistidine (a-FMH, 50 mg/kg, i.p.) significantly reduced wakefulness (W) and light sleep and increased slow wave sleep (SWS) and REM sleep during the light period in rats housed under 12 h light/12 h dark conditions (12L/12D). When animals were housed under 16 h light/8 h dark (16L/8D) they remained awake for a longer period of time during the dark as compared to the 12L/12D lighting cycle. Under this condition a-FMH 50 mg/kg significantly decreased W and increased SWS. Our results tend to indicate that histamine intervenes in sleep-wakefulness regulation. In addition, histamine could be partly involved in the abnormally increased incidence of W observed during the dark in rats housed under 16L/8D conditions.
Monti
J M
JM
Department of Pharmacology and Therapeutics, School of Medicine, Hospital de Clínicas P1, Montevideo, Uruguay.
D'Angelo
L
L
Jantos
H
H
Pazos
S
S
D000818:Animals; D006639:Histidine / Q000031:analogs & derivatives*; D008029:Lighting; D008297:Male; D008762:Methylhistidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects*
D008762:Methylhistidines; D006639:Histidine; C028309:alpha-fluoromethylhistidine