title: The pharmacokinetic profile of naproxen suppository in man.
abstract: After a rectal dose of 500 mg in a suppository, naproxen is 6-O-demethylated (20%) and glucuronidated (40%), the metabolites are subsequently excreted renally. The elimination half-life is 15.2 +/- 2.6 h. Ten out of 22 subjects show biphasic elimination kinetics with half-lives of 7 and 15 h, respectively. There is a wide range in the percentage of the dose that is glucuronidated and demethylated (20-70%). This variation does not deviate from a normal distribution.
authors.affiliation: Farma Research B. V., Ravenstein, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: Guelen
authors.forename: T J
authors.initials: TJ
authors.lastname: Janssen
authors.forename: M M
authors.initials: MM
authors.lastname: Brueren
authors.forename: T B
authors.initials: TB
authors.lastname: Vree
authors.forename: G J
authors.initials: GJ
authors.lastname: Lipperts
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D009288:Naproxen / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics*; D013488:Suppositories
chemical_list: D013488:Suppositories; D009288:Naproxen; C034451:desmethylnaproxen