Selective and semiselective low-density lipoprotein apheresis in familial hypercholesterolemia.
Seven patients with familial hypercholesterolemia were treated fortnightly for 3 months by selective low-density lipoprotein apheresis with dextran-sulfate cellulose column (DSC). Subsequently, 4 of them were treated with semiselective double filtration. No cholesterol-lowering drugs were given. Plasma processed ranged from 39 to 58 ml/kg body weight/procedure. Fractional removals from plasma filtrate at the secondary treatment (adsorption or fractionation) for total cholesterol, high-density lipoprotein cholesterol, and albumin, respectively, were 0.84, 0.06, and 0.03 with DSC and 0.74, 0.47 and 0.35 with double filtration. Postapheresis reductions of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were 57, 15, and 59% with DSC and 47,35, and 48% with double filtration. Both methods are suitable for clinical use, but with a 15-day treatment schedule, lowering circulating lipid fraction levels are maintained with DSC.
Busnach
G
G
Divisione di Nefrologia, Ospedale Cà Granda, Milano, Italia.
Cappelleri
A
A
Vaccarino
V
V
Franceschini
G
G
Dal Col
A
A
Perrino
M L
ML
Brando
B
B
Sirtori
C
C
Minetti
L
L
D000293:Adolescent; D000328:Adult; D001059:Apoproteins / Q000097:blood; D001781:Blood Component Removal / Q000379:methods*; D002648:Child; D002784:Cholesterol / Q000097:blood; D005260:Female; D006440:Hemofiltration; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged
D001059:Apoproteins; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D002784:Cholesterol