Vasopressin secretion during hyperglycemia in insulin-dependent diabetics.
Plasma levels of vasopressin (AVP) were measured in ten insulin-dependent diabetic patients before and during intravenous administration of hypertonic glucose. Plasma glucose and plasma osmolality increased from 12.4 +/- 1.2 to 47.0 +/- 2.3 mmol/l and from 293 +/- 2.0 to 307 +/- 2.8 mosm/kg respectively. Plasma vasopressin increased in parallel from 5.6 +/- 0.6 to 7.7 +/- 0.6 pg/ml. The present results demonstrate that hyperglycemia may be an effective stimulus for AVP secretion in insulin-deficient diabetics.
Grimaldi
A
A
INSERM 64, Hôpital Tenon, Paris, France.
Pruszczynski
W
W
Jacquin
V
V
Thervet
F
F
Ardaillou
R
R
D000328:Adult; D000368:Aged; D001127:Arginine Vasopressin / Q000097:blood / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001798:Blood Proteins / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology*; D005947:Glucose; D005950:Glucose Solution, Hypertonic; D006801:Humans; D008875:Middle Aged; D012964:Sodium / Q000097:blood; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D001798:Blood Proteins; D005950:Glucose Solution, Hypertonic; D001127:Arginine Vasopressin; D014508:Urea; D012964:Sodium; D005947:Glucose