Metabolic products of microorganisms. 243. Pyridazomycin, a new antifungal antibiotic produced by Streptomyces violaceoniger.
Pyridazomycin, a new antifungal antibiotic produced by Streptomyces violaceoniger sp. griseofuscus (strain Tü 2557), was detected in a selective screening against Mucor hiemalis (Tü 179/180). The amino acid side chain of 1 can be seen as L-ornithine, whose gamma-nitrogen atom is part of a pyridazine ring building a quaternary ammonium system. The structure of 1 was established by spectroscopic analysis of the parent compound and degradation products. The occurrence of a pyridazine ring in microbial secondary metabolites is unique.
Grote
R
R
Institut für Organische Chemie, Universität Göttingen, FRG.
Chen
Y
Y
Zeeck
A
A
Chen
Z X
ZX
Zähner
H
H
Mischnick-Lübbecke
P
P
König
W A
WA
D000935:Antifungal Agents / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D002853:Chromatography, Liquid; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D011724:Pyridazines / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000032:analysis
D000935:Antifungal Agents; D011724:Pyridazines; C056340:pyridazomycin