The "pacemaker" function of the transient outward current in the rabbit myocardium.
The single sucrose gap technique was employed to study the electrically induced automaticity in rabbit papillary muscles. When the potential was clamped at the level of the "maximum diastolic potential" following the first spike of automaticity an initial decline of the outward ionic current with subsequent activation of the delayed potassium current was observed. The initial decline was potential-sensitive with a maximum at approximately -2 mV; it diminished when the rate of stimulation increased and was abolished with 4-aminopyridine plus Sr2+. It is suggested that the transient outward current determines the development of the "pacemaker potential" after the first spike of electrically induced automaticity in rabbit papillary muscles.
Gainullin
R Z
RZ
Institute of Biological Physics, Academy of Sciences of the USSR, Puschino, Moscov Region.
Kukushkin
N I
NI
Kiseleva
R E
RE
Sosunov
E A
EA
D000200:Action Potentials; D000818:Animals; D006329:Heart Conduction System / Q000502:physiology*; D066298:In Vitro Techniques; D008564:Membrane Potentials; D010210:Papillary Muscles / Q000502:physiology; D011188:Potassium / Q000502:physiology; D011817:Rabbits
D011188:Potassium