Long-term carcinogenicity bioassays on three chlorofluorocarbons (trichlorofluoromethane, FC11; dichlorodifluoromethane, FC12; chlorodifluoromethane, FC22) administered by inhalation to Sprague-Dawley rats and Swiss mice.
Three propellant chlorofluorocarbons, namely trichlorofluoromethane (FC11), dichlorodifluoromethane (FC12), and chlorodifluoromethane (FC22) were administered by inhalation at a concentration of 5000, 1000 and 0 ppm, 4 hours daily, 5 days weekly, for 104 and 78 weeks, to rats and mice, respectively. The animals were kept under observation until spontaneous death. Under the experimental conditions, all three compounds failed to show any carcinogenic effects.
Maltoni
C
C
Institute of Oncology F. Addarii, Bologna, Italy.
Lefemine
G
G
Tovoli
D
D
Perino
G
G
D000280:Administration, Inhalation; D000310:Adrenal Gland Neoplasms / Q000139:chemically induced; D000818:Animals; D001681:Biological Assay; D005617:Chlorofluorocarbons, Methane / Q000008:administration & dosage / Q000633:toxicity*; D006394:Hemangiosarcoma / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D051379:Mice; D010673:Pheochromocytoma / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains
D005617:Chlorofluorocarbons, Methane; C009755:fluorocarbon 22; C005848:trichlorofluoromethane; C007782:dichlorodifluoromethane