Anti AChR antibody: relevance to diagnosis and clinical aspects of myasthenia gravis.
227 sera from myasthenic patients were tested for the presence of anti-AChR antibodies (anti-AChR Abs) by mean of a fetal calf receptor (Fc-AChR); 73.5% of cases proved positive with this method. Significant correlations were found between presence of anti-Fc-AChr Abs and various clinical aspects such as: clinical stage and duration of disease; moreover significantly higher than the median titers were found among younger patients (i.e. age less than 40 yrs).
Mantegazza
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R
Servizio di Studio e Cura delle Malattie Neuromuscolari, Istituto Neurologico C. Besta, Milano.
Pareyson
D
D
Baggi
F
F
Romagnoli
P
P
Peluchetti
D
D
Sghirlanzoni
A
A
Cornelio
F
F
D000328:Adult; D000367:Age Factors; D001323:Autoantibodies / Q000032:analysis*; D006801:Humans; D007159:Immunologic Tests; D009157:Myasthenia Gravis / Q000175:diagnosis* / Q000276:immunology; D011950:Receptors, Cholinergic / Q000276:immunology*
D001323:Autoantibodies; D011950:Receptors, Cholinergic