title: [Oxytocin and vasopressin in amniotic fluid in humans and rats].
abstract: Oxytocin and vasopressin are hormones having a number of peripheral and (more recently detected) central activities. The two peptides are found to be present in both human amniotic fluid and in that of rats. The origin of these substances was studied in combined clinical and experimental investigations, as were also the relationships of these compounds with intra-uterine growth and the process of labour. Oxytocin was not found to originate from the foetal brain, the foetal adrenals being suggested as a possible alternative source. There was found to be a positive correlation between amniotic oxytocin and measures of the foetal brain, amniotic vasopressin possibly reflecting a poor condition of the foetus (stress?).
authors.affiliation: Groot Ziekengasthuis, Afd. Gynaecologie en Verloskunde, 's-Hertogenbosch.
authors.forename: H P
authors.initials: HP
authors.lastname: Oosterbaan
authors.forename: D F
authors.initials: DF
authors.lastname: Swaab
mesh_terms: D000653:Amniotic Fluid / Q000032:analysis; D000818:Animals; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology; D006801:Humans; D007743:Labor, Obstetric; D008431:Maternal-Fetal Exchange; D010121:Oxytocin / Q000032:analysis / Q000502:physiology*; D010828:Physiology, Comparative; D011247:Pregnancy / Q000502:physiology*; D011270:Pregnancy, Animal / Q000502:physiology*; D051381:Rats / Q000502:physiology*; D014667:Vasopressins / Q000032:analysis / Q000502:physiology*
chemical_list: D014667:Vasopressins; D010121:Oxytocin
vernacular_title: Oxytocine en vasopressine in het amnionvocht bij de mens en de rat.