title: The effects of calcium channel blocking drugs on halothane initiation of malignant hyperthermia in MHS swine and on the established syndrome.
abstract: We have investigated in malignant hyperthermia susceptible swine in vivo the effects on halothane initiation of the MH syndrome and on the established syndrome of five calcium channel blocking drugs--nifedipine, nisoldipine, diltiazem, verapamil and flunarazine. Nifedipine alone caused attenuation of halothane-initiated malignant hyperthermia to the extent of blocking onset of the syndrome in 29% of animals for the 60 minute period of exposure. In the face of the established malignant hyperthermia syndrome, all the drugs tested were therapeutically completely ineffective.
authors.affiliation: Department of Anaesthesia, University of Cape Town Medical School, Observatory, South Africa.
authors.forename: G G
authors.initials: GG
authors.lastname: Harrison
authors.forename: I G
authors.initials: IG
authors.lastname: Wright
authors.forename: D F
authors.initials: DF
authors.lastname: Morrell
mesh_terms: D000768:Anesthesia, General; D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004110:Diltiazem / Q000627:therapeutic use; D005444:Flunarizine / Q000627:therapeutic use; D006221:Halothane; D008305:Malignant Hyperthermia / Q000517:prevention & control*; D009543:Nifedipine / Q000031:analogs & derivatives / Q000627:therapeutic use; D015737:Nisoldipine; D013552:Swine; D014700:Verapamil / Q000627:therapeutic use
chemical_list: D002121:Calcium Channel Blockers; D015737:Nisoldipine; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine; D005444:Flunarizine; D006221:Halothane