The binding of an indefinitely associating ligand to acceptor: consideration of monovalent ligand species binding to a multivalent acceptor.
Currently available binding theory is extended to incorporate the concept of indefinite self-association of the ligand. Binding equations are formulated in closed form for the case of the binding to a multivalent acceptor of a ligand capable of isodesmically indefinitely self-associating in a "head-to-tail" mode such that each ligand state bears one site capable of interacting with the acceptor. It is shown both mathematically and by way of numerical example that this system will give rise exclusively to binding curves convex to the r-axis in Scatchard format. Thus, the system provides another example of a binding mechanism capable of generating an apparent negatively co-operative binding response.
Mark
A E
AE
John Curtin School of Medical Research, Australian National University, Canberra, A.C.T., Australia.
Jeffrey
P D
PD
Nichol
L W
LW
D001665:Binding Sites; D008024:Ligands / Q000378:metabolism*; D008956:Models, Chemical
D008024:Ligands