title: MR imaging of rat brain glioma: Gd-DTPA versus Gd-DOTA.
abstract: The enhancement properties of gadolinium diethylenetriaminepentaacetic acid (DTPA) and gadolinium tetraazacyclododecanetetraacetic acid (DOTA) were compared using a rat glioma model. In vitro analysis included the calculation of T1 relaxivity and determination of characteristic curves. Enhancement of the intracerebral glioma was studied in 23 rats approximately 2 weeks after glioma implantation with Gd-DTPA in 12 rats and Gd-DOTA in 11 rats. Six rats were also studied 1 week after implantation. Gd-DTPA exhibited a slightly greater T1 relaxivity in vitro than Gd-DOTA. Enhancement of the glioma was also greater with Gd-DTPA than with Gd-DOTA (P less than .05).
authors.affiliation: Department of Radiology, New England Medical Center Hospitals, Boston, MA 02111.
authors.forename: V M
authors.initials: VM
authors.lastname: Runge
authors.forename: S
authors.initials: S
authors.lastname: Jacobson
authors.forename: M L
authors.initials: ML
authors.lastname: Wood
authors.forename: D
authors.initials: D
authors.lastname: Kaufman
authors.forename: L S
authors.initials: LS
authors.lastname: Adelman
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis*; D005682:Gadolinium; D019786:Gadolinium DTPA; D005910:Glioma / Q000175:diagnosis*; D006571:Heterocyclic Compounds; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D004369:Pentetic Acid; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium; D019786:Gadolinium DTPA