title: The effects of oral and intraperitoneal administration of ethanol on the activities of hepatic glucose-6-phosphate and 6-phosphogluconate dehydrogenases in rats.
abstract: The activities of hepatic glucose-6-phosphate and 6-phosphogluconate dehydrogenases decreased significantly only in male rats, when rats of both sexes were fed a 2% sucrose solution containing 25% ethanol for six weeks. Sucrose (2%) activation of these enzymes was significant only in female rats. The daily administration of ethanol (5 g/kg body wt.) by intraperitoneal injection for two weeks significantly decreased the activities of these enzymes and eliminated the sex differences in the response to ethanol ingestion.
authors.affiliation: Dolphus E. Milligan Science Research Institute, Atlanta University Center, GA 30310.
authors.forename: S E
authors.initials: SE
authors.lastname: Ibim
authors.forename: P F
authors.initials: PF
authors.lastname: Han
authors.forename: N L
authors.initials: NL
authors.lastname: Emmett
authors.forename: L B
authors.initials: LB
authors.lastname: Cabey
authors.forename: J
authors.initials: J
authors.lastname: Johnson
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010734:Phosphogluconate Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D012737:Sex Factors
chemical_list: D000431:Ethanol; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase