title: Echocardiographic indexes of left ventricular contractility. Effect of load manipulation in arterial hypertension.
abstract: Load changes were obtained in 7 females with untreated primary hypertension by means of controlled intravenous infusion of sodium nitroprusside (0.2 mg/ml), in order to assess variations in the more usual indexes of left ventricular (LV) contractility to different loads and to verify that those indexes were independent of load. 2D-controlled M-mode echocardiograms were performed at baseline and when systolic blood pressure (SBP) had been reduced by 7, 16 and 23% for at least 5 min. Heart rate did not change during the test; decrease in SBP was associated with either decreases in both end-systolic dimension (LVIDs) and end-systolic stress (ESS), or an increase in systolic function. SBP/LVIDs, SBP/end-systolic volume (ESV) and ESS/LVIDs ratios were examined and compared as indexes of contractile state. SBP/ESV and ESS/LVIDs ratios showed great variation at all stages as compared to baseline values, while the SBP/LVIDs ratio did not change. The percent variation between the baseline values and the last stage of the test was 51% for the ESS/LVIDs ratio, 37% for the SBP/ESV and 5% for the SBP/LVIDs ratio. Best-fitting regression showed that a linear relationship existed only between SBP and LVIDs. Echocardiographic two-dimensional (as ESS) or three-dimensional derivations (as ESV) should be carefully employed when the contractile state is studied, while the SBP/LVIDs ratio can be easily used as a baseline value, as it is insensitive to changes in load.
authors.affiliation: Cardiology Unit, University of Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: de Simone
authors.forename: L
authors.initials: L
authors.lastname: di Lorenzo
authors.forename: G
authors.initials: G
authors.lastname: Costantino
authors.forename: S
authors.initials: S
authors.lastname: Buonissimo
authors.forename: D
authors.initials: D
authors.lastname: Moccia
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000187:drug effects; D009599:Nitroprusside / Q000494:pharmacology; D013599:Systole / Q000187:drug effects
chemical_list: D009599:Nitroprusside