title: Rapidly growing mature teratoma of the mediastinum: do sex hormones affect growth of the tumor?
abstract: The case of a 12-year-old girl with an anterior mediastinal tumor is reported. A mass grew rapidly and occupied the anterior mediastinum after menarche. Resected material was diagnosed as a mature teratoma. Both estrogen receptors and progesterone receptors were detected in the resected tissue. The titer of estrogen receptors was 2-11.3 femtomoles per milligram of protein and that of progesterone receptors was 9.5-15.7 fmol/mg protein. Based on these data, it was surmised that sex hormones may affect the growth of the tumor in this case. The change in sex hormones after menarche may have played a role in the rapid growth of this tumor.
authors.affiliation: Second Department of Surgery, School of Medicine, University of Tokushima, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Uyama
authors.forename: Y
authors.initials: Y
authors.lastname: Monden
authors.forename: K
authors.initials: K
authors.lastname: Harada
authors.forename: S
authors.initials: S
authors.lastname: Kimura
authors.forename: T
authors.initials: T
authors.lastname: Morimoto
authors.forename: K
authors.initials: K
authors.lastname: Miura
authors.forename: T
authors.initials: T
authors.lastname: Taniki
authors.forename: N
authors.initials: N
authors.lastname: Tanida
mesh_terms: D002648:Child; D004967:Estrogens / Q000097:blood*; D005260:Female; D006801:Humans; D008479:Mediastinal Neoplasms / Q000032:analysis / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D011374:Progesterone / Q000097:blood*; D011859:Radiography; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D013724:Teratoma / Q000032:analysis / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*
chemical_list: D004967:Estrogens; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011374:Progesterone