[Effect of acetylsalicylic acid on uric acid metabolism in patients with rheumatism].
Concentrations of uric acid (UA) in the blood, saliva, circadian urine and serum xanthinoxidase activity were studied in 150 rheumatic fever patients during acetylsalicylic acid (ASA) therapy. UA concentrations were also studied in the organs (myocardium, mitral cusp, liver and kidneys) of the dead. Low salicylemia in nonreactive rheumatic fever and therapeutic salicylemia in recurrent rheumatic carditis produced a normalizing effect on uric acid metabolism but in limited renal and salivary gland excretory capacity ASA therapy aggravated uric acid metabolic disorder.
Bakhtiiarov
Z A
ZA
Mit'kin
A F
AF
D000328:Adult; D001241:Aspirin / Q000627:therapeutic use*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000188:drug therapy* / Q000378:metabolism; D008946:Mitral Valve Stenosis / Q000188:drug therapy* / Q000378:metabolism; D012214:Rheumatic Heart Disease / Q000188:drug therapy* / Q000378:metabolism; D012463:Saliva / Q000378:metabolism; D014527:Uric Acid / Q000037:antagonists & inhibitors / Q000378:metabolism*
D014527:Uric Acid; D001241:Aspirin
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