The modulation of contraction of fibroblast populated collagen lattices by types I, II, and III collagen.
Human dermal fibroblasts incorporated in a polymerized collagen lattice reduce the size of that matrix. When cell number, collagen concentration, and medium are identical, lattices made with type III collagen contract faster and to a greater degree than those made with type I collagen. The latter contract faster and to a greater degree than those made with type II collagen.
Ehrlich
H P
HP
Wound Healing Laboratory, Shriners Burns Institute, Massachusetts General Hospital, Harvard Medical School, Boston 02114.
D003094:Collagen / Q000502:physiology*; D003285:Contractile Proteins / Q000502:physiology*; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D006801:Humans; D011108:Polymers; D012867:Skin / Q000166:cytology; D012879:Skin Physiological Phenomena
D003285:Contractile Proteins; D011108:Polymers; D003094:Collagen