Serum and cerebrospinal fluid vitamin B12 levels in demented patients with CH3-B12 treatment--preliminary study.
The vitamin B12 (VB12) parameter was studied in the serum and cerebrospinal fluid (CSF) of 14 demented patients. Eleven of these patients were in a state of dementia of the degenerative type such as Alzheimer's disease, senile dementia and Pick's disease. The serum VB12 concentration in all the patients was within normal limits, i.e. 500-1,300 pg/ml. There was no significant difference between the CSF-VB12 levels and the severity of dementia. The serum and CSF-VB12 levels of the demented patients did not show any significant elevation after the oral administration of CH3-B12, 2 mg per day. On the other hand, there was a marked elevation of both the serum and CSF-VB12 after an oral medication (2 mg per day) plus intramuscular administrations (500 micrograms per day). These results confirm that the intramuscular administration of CH3-B12 is an effective way to get a higher value of the serum and CSF-VB12 levels.
Mitsuyama
Y
Y
Department of Psychiatry, Miyazaki Medical College.
Kogoh
H
H
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier / Q000187:drug effects; D003704:Dementia / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D014805:Vitamin B 12 / Q000031:analogs & derivatives / Q000378:metabolism / Q000627:therapeutic use
C019476:mecobalamin; D014805:Vitamin B 12