[Pharmacokinetic study of chloramphenicol in the rabbit].
Chloramphenicol was administered intravenously and orally at a dose of 50 mg/kg to ten rabbits. Pharmacokinetic parameters were calculated (rate constant of terminal phase: beta = 0.21 +/- 0.09 1/h, total body clearance: Cl = 22.7 +/- 2.1 ml/min.kg, bioavailability: F = 42.5 +/- 11.9%) and were used to discuss the proposed dosage. However, caecotrophy might occur and increase absorption of chloramphenicol.
Guillot
P
P
Ministère de l'Agriculture, Laboratoire National des Médicaments Vétérinaires.
Sanders
P
P
Mourot
D
D
D000284:Administration, Oral; D000818:Animals; D002701:Chloramphenicol / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits
D002701:Chloramphenicol
Etude pharmacocinétique du chloramphénicol chez le lapin.