[Effect of lipostabil on cholesterol levels in atherosclerotic plaques of the human aorta and the aggregative capacity of thrombocytes (in vitro study)].
It was found out that lipostabil induced decrease in cholesterol contents in both organ and primary culture of human aorta atherosclerotic plaques. This phenomenon was caused by the effect of lipostabil on cellular output of cholesterol. The study of concentration dependence showed that the cholesterol-decreasing effect of lipostabil was maximal at its concentration in the medium over 250 microliter/ml. At such concentration lipostabil had no significant effect on the blood rheology and inhibited to a great extent platelet aggregation induced by phospholipid platelet activating factor and by some other agents.
Khashimov
Kh A
KhA
Okur
F
F
Orekhov
A N
AN
Kurdanov
Kh A
KhA
Tertov
V
V
D000924:Anticholesteremic Agents; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D001018:Aortic Diseases / Q000378:metabolism*; D001161:Arteriosclerosis / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors
D000924:Anticholesteremic Agents; D010713:Phosphatidylcholines; D010975:Platelet Aggregation Inhibitors; C005152:lipostabil; D002784:Cholesterol
Vliianie lipostabila na soderzhanie kholesterina v ateroskleroticheskoĭ bliashke aorty cheloveka i agregatsionnuiu sposobnost' trombotsitov (issledovanie in vitro).