Ultrastructural study on the invasion of the basal lamina of retinal inner limiting membrane by esophageal carcinoma cells.
Esophageal carcinoma cells EC/CUHK1 were allowed to interact with the basal lamina of the inner limiting membrane of the retina in vitro. Both scanning and transmission electron microscopy revealed that tumour cells first attached to the basal lamina with filopodia and subsequently invaded into the ganglion cell layer of the retina. In addition, transmission electron microscopic studies demonstrated that tumour cells induced mechanical distortion as well as dissolution of the basal lamina.
Chew
E C
EC
Department of Anatomy, Chinese University of Hong Kong, Shatin NT.
Mok
C H
CH
Wong
W W
WW
Jen
L S
LS
Riches
D J
DJ
D000818:Animals; D002277:Carcinoma / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000473:pathology*; D005109:Extracellular Matrix / Q000648:ultrastructure; D008297:Male; D008566:Membranes / Q000648:ultrastructure; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009361:Neoplasm Invasiveness / Q000648:ultrastructure*; D051381:Rats; D012160:Retina / Q000648:ultrastructure*; D014407:Tumor Cells, Cultured / Q000473:pathology