[Plasma concentration of alpha-interferon following continuous subcutaneous infusion].
Three or six million units of alpha-Interferon (HLBI) were administered continuously to cancer patients for 24 hours by subcutaneous infusion using Sp-3 microinfusion pump made by Nipro Company. The plasma concentrations after continuous subcutaneous infusion during more than 48 degrees hours were 20.3 IU/ml (10.8-31.9) at 3 x 10(6) IU HLBI and 44.5 IU/ml (9.1-89.2) at 6 x 10(6) IU HLBI. We think that continuous subcutaneous infusion of HLBI is worthy for the treatment of out-patients with malignant tumor, because they do not need to visit hospital daily and also continuous infusion reduces the toxicity of HLBI.
Tari
K
K
Dept. of Urology, Saitama Cancer Center.
Tsujii
T
T
Yonese
J
J
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007370:Interferon Type I / Q000008:administration & dosage / Q000097:blood*; D007680:Kidney Neoplasms / Q000097:blood / Q000628:therapy; D008297:Male; D008875:Middle Aged
D007370:Interferon Type I