title: Synthesis and biological activity of 2-lactonyl penems.
abstract: A series of potent antibacterial agents have been prepared. These agents are penems carrying a lactone ring in the C-2 position. Excellent activity against Gram-positive and Gram-negative organisms--except Pseudomonas aeruginosa--was found.
authors.affiliation: Pharmaceutical Research Department, Ciba-Geigy Ltd., Basel, Switzerland.
authors.forename: H G
authors.initials: HG
authors.lastname: Capraro
authors.forename: E
authors.initials: E
authors.lastname: Francotte
authors.forename: B
authors.initials: B
authors.lastname: Kohler
authors.forename: G
authors.initials: G
authors.lastname: Rihs
authors.forename: P
authors.initials: P
authors.lastname: Schneider
authors.forename: R
authors.initials: R
authors.lastname: Scartazzini
authors.forename: O
authors.initials: O
authors.lastname: Zak
authors.forename: W
authors.initials: W
authors.lastname: Tosch
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004355:Drug Stability; D007769:Lactams; D008968:Molecular Conformation
chemical_list: D000900:Anti-Bacterial Agents; D007769:Lactams