title: Fatty acid composition of macrophage phospholipids in mice fed fish or borage oil.
abstract: The polyunsaturated fatty acid (PUFA) composition of murine peritoneal macrophage phospholipids was dramatically altered in vivo following the four-wk feeding of specific dietary oils. Fish oil (containing 20:5n-3 and 22:6n-3) feeding significantly increased macrophage 20:5n-3, 22:5n-3, and 22:6n-3 (P less than 0.05), while borage oil (containing 18:2n-6 and 18:3n-6) increased (P less than 0.05) the macrophage 20:3n-6/20:4n-6 ratio, relative to safflower oil (containing 18:2n-6) and hydrogenated coconut oil (containing 12:0)-fed animals. The macrophage phospholipid PUFA profiles were compared with those of the liver, lung and spleen. The significance of the PUFA alterations is discussed.
authors.affiliation: Department of Human Anatomy, School of Medicine, University of California, Davis 95616.
authors.forename: R S
authors.initials: RS
authors.lastname: Chapkin
authors.forename: S D
authors.initials: SD
authors.lastname: Somers
authors.forename: L
authors.initials: L
authors.lastname: Schumacher
authors.forename: K L
authors.initials: KL
authors.lastname: Erickson
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage; D005231:Fatty Acids, Unsaturated / Q000032:analysis*; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D008099:Liver / Q000032:analysis; D008264:Macrophages / Q000032:analysis*; D051379:Mice; D008810:Mice, Inbred C57BL; D009821:Oils / Q000494:pharmacology*; D010743:Phospholipids / Q000032:analysis*; D013154:Spleen / Q000032:analysis
chemical_list: D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D009821:Oils; D010743:Phospholipids