[Study of anti-ischemic effects of verapamil and nifedipine after long-term treatment of patients with exertion-induced stenocardia].
The effects of verapamil and nifedipine taken as single doses and regular treatment, its mean duration being 2.9 and 2.8 months, respectively, were compared by means of repeated standard treadmill exercise in 22 patients with stable angina of effort. Verapamil taken as a mean standard dose of 413 +/- 18 mg was shown to produce anti-ischemic effect in the whole group that, in most cases, increased in relation to longer duration of treatment. Regular use of nifedipine (a mean daily dose of 86 +/- 5 mg) was associated with decreasing effect of the drug. Moreover, different patients showed different trends in terms of treatment efficiency (constant, growing or declining effect) both with verapamil and nifedipine.
Slastnikova
I D
ID
Riabokon'
O S
OS
Metelitsa
V I
VI
D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D003326:Coronary Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage*; D005082:Physical Exertion; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage*
D014700:Verapamil; D009543:Nifedipine
Izuchenie vyrazhennosti antiishemicheskogo éffekta verapamila i nifedipina pri dlitel'nom lechenii bol'nykh so stenokardieĭ napriazheniia.