Multi- and single-fibre mesenteric and renal sympathetic responses to chemical stimulation of intestinal receptors in cats.
1. In cats anaesthetized with alpha-chloralose and artificially respired, stimulation of intestinal receptors with bradykinin caused greater reflex excitation of mesenteric than of renal efferent multifibre nerve activity and significant pressor responses. 2. Activity of all nerve bundles used in this study was inhibited by stimulation of pressoreceptors. Increases in systemic arterial pressure caused inhibition of activity of renal nerves which was significantly greater than that of mesenteric nerves. 3. Spinal transection caused significant decreases in tonic renal nerve activity without altering the ongoing discharge rate of mesenteric nerves. Stimulation of intestinal receptors in spinal cats still caused significant increases is discharge of mesenteric and renal nerves, indicating that this reflex contains a spinal component. 4. Recordings of activity of individual fibres within mesenteric (21) and renal (23) nerves provided information regarding the basis for the multifibre responses to stimulation of intestinal receptors. The same proportion of fibres from both nerves was excited, but the increase in activity of mesenteric fibres was significantly greater than that of renal fibres. 5. Mesenteric fibres could be classified into two groups, based on their sensitivity to pressoreceptor influences. Fibres that exhibited pressoreceptor-independent discharge had the greatest responses to stimulation of intestinal receptors. 6. Following spinal transection the majority of mesenteric fibres continued to fire, whereas most renal fibres became quiescent. 7. The non-uniform pattern of neuronal excitation to chemical stimulation of intestinal receptors was manifest after spinal transection, demonstrating that exclusively spinal pathways can mediate this differential response pattern. 8. These results support the hypothesis that viscero-sympathetic reflexes may be organized to cause preferential excitation of neural activity directed to the organ from which the reflex originates.
Stein
R D
RD
Department of Physiology, Michigan State University, East Lansing 48824-1101.
Weaver
L C
LC
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure; D001920:Bradykinin / Q000494:pharmacology; D002415:Cats; D007421:Intestine, Small / Q000294:innervation*; D007668:Kidney / Q000294:innervation; D008465:Mechanoreceptors / Q000502:physiology; D008643:Mesentery / Q000294:innervation; D009412:Nerve Fibers / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology; D012018:Reflex / Q000502:physiology*; D011984:Sensory Receptor Cells / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*
D001920:Bradykinin