Abnormally banded region in a poorly differentiated sarcoma is not correlated with amplification of c-MYC or c-MOS protooncogenes.
A poorly differentiated sarcoma in a 32-year-old female revealed a large, abnormally banded region in one chromosome #8 in all metaphases. The modal karyotype was 46,XX, -8, +mar. Southern blot hybridization was performed with probes for two protooncogenes located in chromosome 8q (c-MYC and c-MOS). No amplification or rearrangement was observed to account for the cytogenetic abnormality.
Kakati
S
S
Roswell Park Memorial Institute, Buffalo, New York.
Limon
J
J
Dal Cin
P
P
Pietrzak
E
E
Kinniburgh
A J
AJ
Li
F P
FP
Sandberg
A A
AA
D000328:Adult; D000818:Animals; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002898:Chromosomes, Human, Pair 8; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D006801:Humans; D007621:Karyotyping; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes; D012509:Sarcoma / Q000235:genetics* / Q000473:pathology; D014183:Transplantation, Heterologous
D004273:DNA, Neoplasm