Effect of monocytopenia on trauma-induced atherosclerotic lesions in the rabbit ear artery.
In a trauma model of atherosclerosis (repeated mechanical injury of the rabbit ear artery), rabbits were pretreated either with etoposid (inducing a monocytopenia) or with prednisolone (inhibiting monocyte function) to investigate the role of monocytes in traumatically induced plaque formation. Three weeks after the last injury the arteries were carefully examined. While a profound monocytopenia during the period of injuries did not at all influence the size of the plaque formation, this was almost completely inhibited in the prednisolone-treated rabbits. Obviously, the effect of prednisolone must be attributed to other pharmacological properties. Monocytes appear to be of less importance in purely trauma atherosclerosis models.
Voss
R
R
Department of Internal Medicine, Justus-Liebig-University, Giessen, Federal Republic of Germany.
Mueller
I R
IR
Matthias
F R
FR
D000818:Animals; D001158:Arteries / Q000473:pathology*; D001161:Arteriosclerosis / Q000097:blood* / Q000473:pathology; D004195:Disease Models, Animal; D005047:Etoposide / Q000494:pharmacology; D005260:Female; D006400:Hematocrit; D007958:Leukocyte Count; D007970:Leukopenia / Q000473:pathology; D009000:Monocytes / Q000502:physiology*; D011239:Prednisolone / Q000494:pharmacology; D011817:Rabbits
D005047:Etoposide; D011239:Prednisolone