title: [Insulin-resistant diabetes and polycystic ovary].
abstract: The observation of one patient with insulin resistance (114 unités of soluble insulin in 3 injections per day + 54 units of medium acting insulin at 8 pm) associated with a polycystic ovarian disease prompted us to discuss the relationship between hyperandrogenism, acanthosis nigricans and endogenous hyperinsulinism. An in vitro study of the insulin binding to patient's erythrocytes allowed to diagnose the rare Type A insulin-resistance syndrome proposed by Kahn.
authors.affiliation: Service de Médecine B Endocrinologie, CHU Bretonneau, Tours.
authors.forename: P
authors.initials: P
authors.lastname: Lecomte
authors.forename: C
authors.initials: C
authors.lastname: Ledevehat
authors.forename: J L
authors.initials: JL
authors.lastname: Chaussain
authors.forename: D
authors.initials: D
authors.lastname: Royere
authors.forename: G
authors.initials: G
authors.lastname: Bertrand
mesh_terms: D000293:Adolescent; D048909:Diabetes Complications; D005260:Female; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology; D007333:Insulin Resistance; D010048:Ovarian Cysts / Q000150:complications*; D013577:Syndrome
vernacular_title: Diabète insulino-résistant et ovaire polykystique.