Heating reactivation of rats aminolevulinic acid dehydratase in lead poisoning.
Heat reactivation (60 degrees C for 5 minutes) of the red blood cells aminolevulinic acid dehydratase activity was studied in lead treated rats (0.25 to 5.0 mg/kg b.w., i.p., for 4 weeks). Complete enzyme reactivation occurs with lead blood concentration up to about 70 mcg/dl. At higher blood lead concentrations, only a part of the enzyme can be restored by heating. The different mechanisms of aminolevulinic acid dehydratase activity inhibition by lead are discussed.
Trevisan
A
A
Istituto di Medicina del Lavoro, Università di Padova, Italy.
Raimondi
M
M
Bungaro
A
A
Chiesura
P
P
D000818:Animals; D004789:Enzyme Activation; D006358:Hot Temperature; D007855:Lead Poisoning / Q000097:blood / Q000201:enzymology*; D008297:Male; D000623:Porphobilinogen Synthase / Q000037:antagonists & inhibitors / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D000623:Porphobilinogen Synthase