title: [Acute lowering of blood pressure by infusion of hyperosmolal sorbitol solution in brain operations. Dangerous adverse effect or favorable side effect?].
abstract: Osmotherapy with sorbitol 40% during intracranial surgery using neurolept analgesia usually produced acute decreases in arterial blood pressure. Haemodynamical measurements during intraoperative infusions of sorbitol in 97 patients showed a rapid decrease of arterial mean pressure from 91 to 72 mm Hg. In 22 of these patients cardiac output measurements were performed. Increases of cardiac index from 2.5 to 4.3 l/min x m2 could be found. The hypotensive side effect can be used for treatment of reactive arterial hypertension in neurosurgical patients during surgery where this therapy is advantageous per se because of its cerebral dehydrating effects. The decrease of blood pressure is obviously caused by peripheral vasodilatation. Cardiac disturbances were not observed. Other side effects, especially the danger of hereditary fructose intolerance are discussed.
authors.affiliation: Abt. Anästhesiologie II, Medizinische Hochschule Hannover.
authors.forename: B
authors.initials: B
authors.lastname: Panning
authors.forename: S
authors.initials: S
authors.lastname: Piepenbrock
authors.forename: J
authors.initials: J
authors.lastname: Schäffer
authors.forename: D
authors.initials: D
authors.lastname: Stolke
mesh_terms: D001794:Blood Pressure / Q000187:drug effects*; D001927:Brain Diseases / Q000601:surgery*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006982:Hypertonic Solutions; D007427:Intracranial Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009458:Neuroleptanalgesia; D013012:Sorbitol / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D006982:Hypertonic Solutions; D013012:Sorbitol
vernacular_title: Akute Blutdrucksenkung durch Infusion hyperosmolaler Sorbit-Lösung bei Hirnoperationen. Gefährliche Nebenwirkung oder günstiger Seiteneffekt?