Severe mitochondrial anomaly in dystrophic mouse skeletal muscle.
Mitochondrial fractions were isolated from skeletal muscle of control (C57 BL 6J dy/+) and dystrophic (C57 BL 6J dy/dy) mice, and enzymatic activities (cytochrome c oxidase, rotenone-insensitive NADH cytochrome c reductase) were determined. After electrophoretic separation, calcium-binding proteins were identified. An important anomaly was observed in the mitochondria of dystrophic muscle, i.e., a considerable reduction of a specific calcium-binding protein (61,000 Da mol. wt.).
Lucas-Heron
B
B
Laboratoire de Physiologie-U.E.R. de Médecine, Nantes, France.
Loirat
M J
MJ
Ollivier
B
B
D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008931:Mitochondria, Muscle / Q000378:metabolism; D008970:Molecular Weight; D009132:Muscles / Q000378:metabolism* / Q000648:ultrastructure; D009137:Muscular Dystrophy, Animal / Q000378:metabolism* / Q000473:pathology; D013347:Subcellular Fractions
D002135:Calcium-Binding Proteins