Plasma catecholamine level and portal venous pressure as guides to prognosis in patients with cirrhosis.
Circulating noradrenaline is increased in patients with cirrhosis, especially in decompensated patients with ascites. Eighty-one patients with alcoholic cirrhosis were followed for up to 8 years in order to establish a possible relationship between plasma catecholamines, haemodynamics, and routine clinical and biochemical variables and survival. Forty-seven (58%) of the patients died during the follow-up period. Univariate analysis showed that plasma noradrenaline and adrenaline concentrations, portal pressure, indocyanine green clearance, serum sodium, bilirubin, and albumin concentrations, and the presence of ascites or cardiovascular disease were of significant prognostic value. In a multivariate analysis (Cox regression model), plasma noradrenaline concentration, portal pressure, serum bilirubin concentration, and the presence of ascites and cardiovascular disease remained significant independent predictors of survival. The results suggest that determination of the circulating level of noradrenaline and portal pressure may add to the prognostic information on survival obtained from routine tests. Thus, the activity of the sympathetic nervous system may indicate the severity of cirrhosis with respect to survival.
Tage-Jensen
U
U
Department of Clinical Physiology, Hvidovre Hospital, Copenhagen, Denmark.
Henriksen
J H
JH
Christensen
E
E
Widding
A
A
Ring-Larsen
H
H
Christensen
N J
NJ
D000328:Adult; D000368:Aged; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006801:Humans; D007526:Isoelectric Point; D008103:Liver Cirrhosis / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D011169:Portal Vein; D011379:Prognosis; D014690:Venous Pressure
D009638:Norepinephrine; D004837:Epinephrine