Effect of pteridines on normal and neoplastic cell lines of Xiphophorus.
The effect of three pteridines namely biopterin, isoxanthopterin and xanthopterin on cell growth, viability and morphology of three embryo and one melanoma derived cell lines was studied. Pteridines were assayed in the range of 10(-6) M to 10(-4) M. Biopterin exerted no influence on all cell lines tested, whereas isoxanthopterin and xanthopterin caused a decrease in growth rate with increasing concentrations. The strongest decrease of cell growth was exerted by 10(-4) M xanthopterin. Furthermore at this concentration xanthopterin reduced the viability of normal cells and influenced the morphology of both normal and neoplastic cells. In general, normal cells were more sensitive to pteridines than neoplastic cells.
Ritter
S
S
Institute of Genetics of the Justus-Liebig-University, Giessen, FRG.
Henze
M
M
Anders
F
F
D000818:Animals; D001708:Biopterins / Q000494:pharmacology*; D002452:Cell Count / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003532:Cyprinodontiformes / Q000196:embryology*; D007700:Kinetics; D008545:Melanoma / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D014976:Xanthopterin / Q000494:pharmacology*
D001708:Biopterins; C008217:isoxanthopterin; D014976:Xanthopterin