Hb Las Palmas or alpha 2 beta 2(49)(CD8)Ser----Phe, a mildly unstable hemoglobin variant.
A new hemoglobin variant with a Ser----Phe substitution at position beta 49(CD8) was discovered in two members of a family living in the Canary Islands, Spain. Detection was by polyacrylamide gel electrophoresis and by reversed phase high performance liquid chromatography. The variant, which constituted 43% and 45%, respectively, in the two heterozygotes, was slightly unstable. Its presence did not affect hematological values though there was a mild reticulocytosis.
Malcorra-Azpiazu
J J
JJ
Departamento de Hematologia-Hemoterapia Hospital Materno-Infantil, Insalud, Canary Islands, Spain.
Balda-Aguirre
M I
MI
Diaz-Chico
J C
JC
Hu
H
H
Wilson
J B
JB
Webber
B B
BB
Kutlar
F
F
Kutlar
A
A
Huisman
T H
TH
D000328:Adult; D000595:Amino Acid Sequence; D005914:Globins / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics* / Q000302:isolation & purification; D006579:Heterozygote; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D013030:Spain
D006455:Hemoglobins, Abnormal; C056395:hemoglobin Las Palmas; D005914:Globins