Ultrastructural aspects of the goiter in cog/cog mice.
Thyroids of congenitally goitrous (cog/cog) mice were studied with light and electron microscopy. The principal alteration in follicular cells was their largely overdistended rough endoplasmic reticulum (RER). Our findings resemble the ultrastructural features of human hypothyroid goiter caused by a thyroglobulin (TG) defect and thus support the previously suggested abnormalities of TG synthesis and/or processing in cog/cog mice.
Mayerhofer
A
A
Department of Physiology, School of Medicine, Southern Illinois University, Carbondale 62901-6512.
Amador
A G
AG
Beamer
W G
WG
Bartke
A
A
D000818:Animals; D004721:Endoplasmic Reticulum / Q000473:pathology / Q000648:ultrastructure; D006042:Goiter / Q000209:etiology / Q000235:genetics*; D006720:Homozygote; D008297:Male; D051379:Mice; D013954:Thyroglobulin / Q000096:biosynthesis / Q000378:metabolism; D013961:Thyroid Gland / Q000473:pathology / Q000648:ultrastructure*; D013972:Thyrotropin / Q000502:physiology; D014617:Vacuoles / Q000648:ultrastructure
D013972:Thyrotropin; D013954:Thyroglobulin