title: Haemorrhagic necrosis of the grey matter of the spinal cord due to accidental injection of iopamidol in a patient with multiple neurofibromas; a clinico-pathological study.
abstract: Cervical laminectomy was performed in a 34-year-old man with multiple spinal neurofibromas because of a slowly progressive medullary compression. Four weeks later a rapid deterioration necessitated iopamidol myelography by left lateral cervical puncture at C2 level. Despite the establishment of adequate spinal fluid contact, resulting in imaging of the subarachnoid space, part of the contrast medium entered the spinal cord, thus delineating a syrinx from the upper cervical extending to the upper thoracic level. After the puncture the patient developed triplegia, involving the left arm and both legs and a paresis of the right arm. He died from aspiration pneumonia. Autopsy revealed haemorrhagic necrosis of the spinal grey matter. This adverse effect of myelography is argued to have been conditioned by the extreme immobility and displacement of the spinal cord due to the presence of multiple neurofibromas. The deterioration four weeks after the operation was probably caused by a further compression of the spinal cord.
authors.affiliation: Department of Neurology, University Hospital Leiden, The Netherlands.
authors.forename: R A
authors.initials: RA
authors.lastname: Roos
authors.forename: J H
authors.initials: JH
authors.lastname: Voormolen
authors.forename: G J
authors.initials: GJ
authors.lastname: Vielvoye
authors.forename: A R
authors.initials: AR
authors.lastname: Wintzen
authors.forename: G T
authors.initials: GT
authors.lastname: Bots
mesh_terms: D000328:Adult; D006470:Hemorrhage / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology; D006801:Humans; D007479:Iopamidol / Q000009:adverse effects*; D008297:Male; D009192:Myelography / Q000009:adverse effects; D009455:Neurofibroma / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery; D013118:Spinal Cord Diseases / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery
chemical_list: D007479:Iopamidol