The coronary arteries in cases of cardiac and noncardiac sudden death.
Thirty-four cardiac and 22 sudden noncardiac deaths in men were examined with an injection, radiographic, and dissection autopsy technique to obtain as many coronary narrowings as possible for study. The narrowest sites in each of the major coronary vessels (LAD, LCX, and RCA) from each subject were identified histologically for analysis. The parameters studied were size of lumen, estimated as percentage of vessel cross-section, vs. the age of subject and the grades of chronic inflammatory cell infiltrate, of neovascularization, of intimal haemorrhage, and of pultaceous cholesterol-rich deposit in the wall. Genstat statistical analysis revealed that the significant explanatory variables for the reduction in arterial lumen were active inflammation and cardiac cause of death. Neither age nor cholesterol-rich deposits had significant explanatory power. A pathogenic role for inflammation may well be possible and efforts will be made in the future to investigate its etiology.
Cliff
W J
WJ
Department of Pathology, University of Washington Medical School, Seattle, Washington.
Heathcote
C R
CR
Moss
N S
NS
Reichenbach
D D
DD
D001158:Arteries; D003331:Coronary Vessels / Q000473:pathology*; D003645:Death, Sudden / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000150:complications*; D014693:Ventricular Fibrillation / Q000150:complications*