[Course of chronic life-threatening digitalis poisoning in infancy with immunopharmacologic treatment using antidigoxin Fab of sheep].
A 2 months old girl was given a tenfold increased dosage of Beta-Methyldigoxin for 2 weeks and subsequently developed severe symptoms of glycoside intoxication. In hospital she was treated by digoxin-specific Fab antibody fragments. 18 hours later the symptoms had totally disappeared. However, 48 hours from the beginning of the treatment free digoxin levels rose again to toxic ranges. In chronic intoxications the rediffusion of glycosides from tissues and interstitial space seems to be much more pronounced than in acute intoxications, and there is a higher risk of reintoxication.
Berger
S
S
Universitäts-Kinderklinik, Mannheim.
Teufel
M
M
Arnold
D
D
Lasch
P
P
Hannack
D
D
Niessen
K H
KH
D002908:Chronic Disease; D004077:Digoxin / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000188:drug therapy*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use*; D007223:Infant; D008520:Medigoxin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*
D007140:Immunoglobulin Fab Fragments; C050199:digoxin antibodies Fab fragments; D004077:Digoxin; D008520:Medigoxin
Verlauf einer chronischen lebensbedrohlichen Digitalis-Intoxikation im Säuglingsalter unter immunpharmakologischer Behandlung mit Antidigoxin Fab vom Schaf.