Discordance of signs in monozygotic twins concordant for the Goldenhar anomaly.
Concordance for Goldenhar anomaly has been described in monozygotic (MZ) twins on 2 occasions but never in dizygotic (DZ) twins. In both cases the twins were similarly, although not identically, affected. We report on a pair of probably monozygotic twins (8% probability of DZ) who presented with extremely diverse manifestations of this anomaly complex. One of them required a tracheostomy because of obstructive apnea due to severe micrognathia and subsequently died. This twin had a midline lower lip cleft which has not previously been described in the Goldenhar anomaly.
Ryan
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CA
Department of Newborn Medicine, Royal Alexandra General Hospital, Edmonton, Alberta, Canada.
Finer
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NN
Ives
E
E
D004200:Diseases in Twins; D005260:Female; D006053:Goldenhar Syndrome / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D008342:Mandibulofacial Dysostosis / Q000235:genetics*; D008445:Maxillofacial Development; D014427:Twins; D014430:Twins, Monozygotic