[Effect of antiadrenergic and myotropic hypotensive agents on the blood kallikrein-kinin system in experimental hypertension].
In the period of vasorenal hypertension formation in rats phase changes in the kallikrein-kinin system of the blood are observed: one month after kidney-skin anastomosis a significant increase of the levels of prekallikrein, kininogen and kallikrein inhibitor is noted and by the end of the second month a drastic decrease of the levels of these components occurs due to the "unregulated" activation of the kallikrein-kinin system of the blood. Antiadrenergic agents (reserpine, tropaphen) prescribed for treatment of hypertension prevent the development of the "unregulated" activation of the kallikrein-kinin system and reduce consumption of its components. These drugs are advisable to use under threat of the kallikrein-kinin system exhaustion. beta-adrenoblocking agent obsidan and myotropic drugs produce a significant enhancement of kallikreino- and kininogenesis, but the degree of activation of the processes is less pronounced than in untreated hypertensive rats.
Abdullina
R N
RN
Davidenko
Iu D
IuD
Fridman
S M
SM
Zaripova
G R
GR
Didenko
R G
RG
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006978:Hypertension, Renovascular / Q000097:blood / Q000188:drug therapy*; D007610:Kallikreins / Q000097:blood*; D007705:Kinins / Q000097:blood*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D051381:Rats; D013565:Sympatholytics / Q000627:therapeutic use*; D013997:Time Factors
D000959:Antihypertensive Agents; D007705:Kinins; D013565:Sympatholytics; D007610:Kallikreins
Vliianie antiadrenergicheskikh i miotropnykh gipotenzivnykh sredstv na kallikrein-kininovuiu sistemu krovi pri éksperimental'noĭ gipertenzii.