Antioxidant effects of exogenous polyamines in damage of lysosomes inflicted by xanthine oxidase or stimulated polymorphonuclear leucocytes.
Active oxygen species produced by the action of xanthine oxidase or stimulated guinea-pig polymorphonuclear leucocytes have a lytic action of lysosomes possibly due to lipid peroxidation. Polyamines give some protection against lysis with putrescine being the most effective polyamine. The possible relevance to inflammatory disease is discussed.
Kafy
A M
AM
Pharmaceutical Sciences Institute, Aston University, Birmingham.
Lewis
D A
DA
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants; D006168:Guinea Pigs; D008054:Lipid Peroxides / Q000378:metabolism; D008247:Lysosomes / Q000187:drug effects* / Q000378:metabolism; D009504:Neutrophils / Q000502:physiology*; D011073:Polyamines / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000494:pharmacology; D014969:Xanthine Oxidase / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D008054:Lipid Peroxides; D011073:Polyamines; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D000135:Acid Phosphatase