Comparative absorption kinetics of imidazole and salicylic acid in volunteers after administration of ITF 182 tablets and suppositories.
Comparative absorption kinetics in volunteers of a new antiinflammatory drug (Selezen), in the form of 750 mg tablets and suppositories, were studied. The two components of the drug, imidazole and salicylic acid were found in plasma. Pharmacokinetic parameters were calculated according to a first order absorption. Salicylic acid showed a maximum concentration 59.2 +/- 5 min and 75.4 +/- 7.6 min after the administration of the tablet and suppository respectively; and imidazole after 86.3 +/- 10.8 min and 75.2 +/- 5.4 min, respectively.
Noseda
G
G
Beata Vergine Hospital, Mendrisio, Tessin, Switzerland.
Fragiacomo
C
C
Peruzzi
M
M
Cremonesi
P
P
Chinea
B
B
D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D012459:Salicylates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D020156:Salicylic Acid; D013488:Suppositories; D013607:Tablets
D007093:Imidazoles; D012459:Salicylates; D013488:Suppositories; D013607:Tablets; D020156:Salicylic Acid