title: Pharmacokinetics of aspirin and chloramphenicol in normal and leprotic patients before and after dapsone therapy.
abstract: Pharmacokinetics of aspirin and chloramphenicol was studied in 16 normal and 16 patients suffering from leprosy. A significant increase (p less than 0.05) in the elimination half-life of chloramphenicol was observed before and after dapsone treatment in leprotic patients as compared with the normal volunteers, while no significant difference was observed in any of the pharmacokinetic parameters with aspirin.
authors.affiliation: Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Garg
authors.forename: B
authors.initials: B
authors.lastname: Kumar
authors.forename: V K
authors.initials: VK
authors.lastname: Shukla
authors.forename: V
authors.initials: V
authors.lastname: Bakaya
authors.forename: R
authors.initials: R
authors.lastname: Lal
authors.forename: S
authors.initials: S
authors.lastname: Kaur
mesh_terms: D000328:Adult; D001241:Aspirin / Q000493:pharmacokinetics*; D002701:Chloramphenicol / Q000493:pharmacokinetics*; D003622:Dapsone / Q000009:adverse effects* / Q000627:therapeutic use; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D007918:Leprosy / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D002701:Chloramphenicol; D003622:Dapsone; D001241:Aspirin