Observations on renal function in workers exposed to lead.
Renal function was studied in 40 workers chronically exposed to lead at a smelter. The geometric means of lead were 40 (range 24.0 - 63.0) micrograms/dl in blood and 47 (range 19 - 115) micrograms/g creatinine or 71 (range 20 - 250) micrograms/l in urine, respectively. There were no significant differences between the lead-exposed group and a control group in the concentrations of beta 2-microglobulin in serum, urinary total protein and IgG, whereas the level of beta 2-microglobulin in urine was significantly higher in the lead-exposed group (p less than 0.01). No individual lead worker showed abnormally increased level of urinary beta 2-microglobulin. The significance of increased excretion of beta 2-microglobulin on the basis of the group remains to be elucidated.
Huang
J X
JX
Institute of Health, Chinese Academy of Preventive Medicine, Beijing.
He
F S
FS
Wu
Y G
YG
Zhang
S C
SC
D004781:Environmental Exposure; D006801:Humans; D007221:Industry; D007677:Kidney Function Tests; D007854:Lead / Q000097:blood* / Q000652:urine; D008991:Monitoring, Physiologic; D011507:Proteinuria
D007854:Lead