HLA-linked susceptibility to rheumatoid arthritis in north India.
Nine multiplex RA families of North Indian origin were tissue typed to determine the segregation of parental haplotypes among sibs. The assortment of haplotypes in 18 affected sibs was not random, with seven sib pairs being HLA identical and two haploidentical with the proband (P = 0.0007). HLA-DR4 occurred in eight out of nine probands (88.8%) and in 11 out of 13 familial RA subjects (84.6%).
Mehra
N K
NK
Department of Anatomy, All-India Institute of Medical Sciences, New Delhi.
Kaul
R
R
Taneja
V
V
Chaudhuri
T K
TK
Jhinghan
B
B
Malaviya
A N
AN
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology*; D004198:Disease Susceptibility; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006239:Haplotypes; D006801:Humans; D007194:India; D008297:Male; D012801:Sibling Relations
D006680:HLA Antigens