The treatment of Friedreich's ataxia with amantadine hydrochloride.
Amantadine hydrochloride (AH) was orally administered to 16 patients with Friedreich's ataxia. We evaluated patient response with the functional ataxia scoring scale and calculated a total disability score. The mean percent improvement of the total disability score was 29.5%; for ambulatory patients alone it was 45.5%. No significant side effects were encountered. AH appears to be a safe and effective symptomatic treatment of Friedreich's ataxia.
Peterson
P L
PL
Department of Neurology, Wayne State University, Detroit, MI.
Saad
J
J
Nigro
M A
MA
D000293:Adolescent; D000328:Adult; D000547:Amantadine / Q000627:therapeutic use*; D002648:Child; D005260:Female; D005621:Friedreich Ataxia / Q000188:drug therapy*; D006801:Humans; D008297:Male
D000547:Amantadine