Resistance to Plasmodium chabaudi in B10 mice: influence of the H-2 complex and testosterone.
Resistance to Plasmodium chabaudi has been examined in different inbred mouse strains bearing identical H-2 haplotypes on different genetic backgrounds as well as in H-2-congenic mouse strains on B10 background. Resistance is expressed in terms of percent survival after a challenge with 10(6) P. chabaudi-infected erythrocytes. We can show that murine resistance to P. chabaudi is under complex polygenic control involving a non-H-2 gene(s) as well as genes in both I-A and I-E subregions of the H-2 complex. Our data indicate in particular that malaria protective antigens can be presented in context with I-Ab molecules but not in context with I-Ak molecules. Resistance controlled by I-Ab does not become apparent when I-Ek molecules are coincidentally expressed. Moreover, testosterone abrogates I-Ab-controlled resistance to P. chabaudi.
Wunderlich
F
F
Division of Parasitology, University of Duesseldorf, Federal Republic of Germany.
Mossmann
H
H
Helwig
M
M
Schillinger
G
G
D000818:Animals; D004198:Disease Susceptibility; D004920:Erythropoiesis; D005260:Female; D006183:H-2 Antigens / Q000235:genetics; D008288:Malaria / Q000097:blood / Q000235:genetics* / Q000469:parasitology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012156:Reticulocytes / Q000473:pathology; D012727:Sex Characteristics; D013739:Testosterone / Q000502:physiology*
D006183:H-2 Antigens; D013739:Testosterone