Type-restricted neutralization of molecular clones of human immunodeficiency virus.
In a study of the immunologic significance of the genetic diversity present within single isolates of human immunodeficiency virus type 1 (HIV-1), the neutralization of viruses derived from molecular clones of the HIV-1 strain HTLV-IIIB by an extensive panel of sera was compared. Sera from HIV-1-infected patients and from goats immunized with polyacrylamide gel-purified HIV-1 envelope glycoprotein (gp120), native gp120, or gp120-derived recombinant peptides, showed marked heterogeneity in neutralizing activity against these closely related viruses. The change of a single amino acid residue in gp120 may account for such "clonal restriction" of neutralizing activity.
Looney
D J
DJ
Department of Viral Diseases, Walter Reed Army Institute of Research, Washington, DC 20307.
Fisher
A G
AG
Putney
S D
SD
Rusche
J R
JR
Redfield
R R
RR
Burke
D S
DS
Gallo
R C
RC
Wong-Staal
F
F
D000595:Amino Acid Sequence; D000914:Antibodies, Viral / Q000276:immunology*; D001667:Binding, Competitive; D003001:Cloning, Molecular; D006678:HIV / Q000235:genetics / Q000276:immunology*; D006679:HIV Seropositivity / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D009842:Oligopeptides / Q000138:chemical synthesis / Q000276:immunology
D000914:Antibodies, Viral; D009842:Oligopeptides