Prediction of benzoyl peroxide phototoxicity by photoepidermotests after repeated applications. Preventive value of a UVB filter.
The predictive phototoxicity test known as photoepidermotest consists of twice daily applications of the product tested for 16 days, followed by total spectrum irradiation with a 2,500-W Xenon lamp in infraerythema and supraerythema doses. Phototoxicity is revealed by an erythema with the infraerythema dose and/or by accentuation of the erythema provoked by the supraerythema dose when compared with the "irradiation only" (i.e., no product) control skin area. This technique, used in a controlled, double-blind trial, showed that a 10% benzoyl peroxide (BPO) gel was phototoxic in eight out of 18 subjects tested (44%). It also showed that adding a UVB filter (phenylbenzimidazole sulfonic acid 1%) to the BPO preparation was effective in preventing phototoxic reactions in seven of these eight subjects.
Jeanmougin
M
M
Service de Dermatologie, Hôpital Saint-Louis, Paris, France.
Civatte
J
J
D000328:Adult; D001562:Benzimidazoles / Q000627:therapeutic use; D001585:Benzoyl Peroxide / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010545:Peroxides / Q000009:adverse effects*; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000517:prevention & control; D011897:Random Allocation; D013451:Sulfonic Acids; D014466:Ultraviolet Rays / Q000009:adverse effects
D001562:Benzimidazoles; D010545:Peroxides; D013451:Sulfonic Acids; C499767:ensulizole; D001585:Benzoyl Peroxide