The role of coagulation, fibrinogenolysis and fibrinolysis in the development of fluid and clotted cadaver plasma.
Parameters for coagulation, fibrinogenolysis and fibrinolysis were measured in order to understand the formation of fluid or clotted cadaver plasma. All values found were distinctly elevated without significant differences between fluid and clotted material. The electrophoretic banding pattern of the fibrinogen and fibrin material also proved extensive coagulation and fibrinolysis in all cases. In vitro experiments in which similar electrophoretic banding patterns were obtained suggested that the development of fluid cadaver plasma depends on the activation of fibrinolysis prior to complete coagulation, and is enhanced by persistence of circulation as well as a physiological pH (7.4). In correspondence to post mortal time only an increase in elastase values was found.
Klaubert
W
W
Med. Klinik III, Klinikum Grosshadern, Munich, FRG.
Schönbauer
R
R
Gilg
T
T
Gollwitzer
R
R
Hafter
R
R
Graeff
H
H
Spann
W
W
Wilmanns
W
W
D001777:Blood Coagulation; D002102:Cadaver; D004797:Enzyme-Linked Immunosorbent Assay; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis; D005344:Fibrinopeptide A / Q000032:analysis; D006801:Humans; D010196:Pancreatic Elastase / Q000097:blood
D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D005344:Fibrinopeptide A; D005340:Fibrinogen; D010196:Pancreatic Elastase