Vitamin E inhibits protein kinase C activity.
Vitamin E (dl-alpha-tocopherol) has been found to inhibit in vitro brain protein kinase c with a half inhibitory concentration of 450 microM. The known plasma concentrations of vitamin E are one order of magnitude lower than the protein kinase c half-inhibitory concentration but it is also known that, at the membrane level where the active protein kinase c is located, the lipophilic vitamin E is more concentrated (Burton, G.W., Joyce, A. and Ingold, K.U. and Locke, S. (1983) Arch. Biochem. Biophys. 221, 281-290). It appears that vitamin E, in addition to its antioxidant function, may play a role in regulating the activity of protein kinase c.
Mahoney
C W
CW
Institut für Biochemie und Molekularbiologie der Universität Bern, Switzerland.
Azzi
A
A
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002417:Cattle; D010743:Phospholipids / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology*
D010743:Phospholipids; D014810:Vitamin E; D011493:Protein Kinase C; D002118:Calcium