title: Zollinger-Ellison syndrome and myelofibrosis in a dog.
abstract: Zollinger-Ellison syndrome and myelofibrosis were diagnosed concurrently in a 10-year-old neutered female Brittany Spaniel. Documentation of gastric ulceration, hypergastrinemia, and gastrin-secreting islet cell tumor with splenic metastases facilitated the diagnosis of Zollinger-Ellison syndrome. Patchy long-bone medullary sclerosis, nonregenerative anemia and thrombocytopenia, multiple acellular bone marrow aspirates, marked splenic extramedullary hematopoiesis, and acellular core bone marrow biopsy with areas of necrosis and fibrosis supported the diagnosis of myelofibrosis. Despite the medical and surgical management attempted, the dog was euthanatized because of signs of severe intractable bone pain. Myelofibrosis has been documented in association with canine and human neoplastic disease. A direct causal relationship between gastrinoma and myelofibrosis was not clearly established in this instance.
authors.affiliation: Department of Companion Animal and Special Species Medicine, School of Veterinary Medicine, North Carolina State University, Raleigh 27606.
authors.forename: R V
authors.initials: RV
authors.lastname: English
authors.forename: E B
authors.initials: EB
authors.lastname: Breitschwerdt
authors.forename: C B
authors.initials: CB
authors.lastname: Grindem
authors.forename: D E
authors.initials: DE
authors.lastname: Thrall
authors.forename: L A
authors.initials: LA
authors.lastname: Gainsburg
mesh_terms: D000818:Animals; D004283:Dog Diseases; D004285:Dogs; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D006811:Humerus / Q000000981:diagnostic imaging; D007794:Lameness, Animal / Q000209:etiology; D055728:Primary Myelofibrosis / Q000150:complications / Q000662:veterinary*; D011859:Radiography; D015043:Zollinger-Ellison Syndrome / Q000150:complications / Q000662:veterinary*