title: Experimental Yersinia-associated arthritis in the spontaneously hypertensive rat.
abstract: Sterile arthritis resembling human reactive arthritis was induced in spontaneously hypertensive SHR rats by intravenous injection of live Yersinia enterocolitica 0:8. Histologically the synovitis appears as proliferation of the lining cell layer, with inflammatory cells present in the subsynovium. The inflammatory cells are mostly lymphocytes. Infection with Yersinia enterocolitica 0:3 or Yersinia pseudotuberculosis did not induce arthritis. Susceptibility to Yersinia-associated arthritis is not determined by the major histocompatibility complex (MHC), since rats of the normotensive control strain (WKY) with the same MHC do not develop arthritis.
authors.forename: P
authors.initials: P
authors.lastname: Toivanen
authors.forename: R
authors.initials: R
authors.lastname: Merilahti-Palo
authors.forename: C
authors.initials: C
authors.lastname: Gripenberg
authors.forename: K O
authors.initials: KO
authors.lastname: Söderström
authors.forename: U M
authors.initials: UM
authors.lastname: Jaakkola
mesh_terms: D000818:Animals; D001170:Arthritis, Infectious / Q000209:etiology* / Q000473:pathology; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013583:Synovial Membrane / Q000473:pathology; D015009:Yersinia Infections / Q000150:complications*; D015008:Yersinia enterocolitica; D015011:Yersinia pseudotuberculosis