Functioning hepatic cell mass and the hyperdynamic state in cirrhosis.
Seventeen patients with advanced hepatic cirrhosis underwent cardiopulmonary assessment by means of Swan-Ganz catheters combined with indocyanine green clearance studies to measure functioning hepatic cell mass. The indocyanine green clearance test was found to have a statistically significant linear correlation with such indicators of the hyperdynamic circulatory state as cardiac index and total peripheral resistance. Results from these studies also showed that the hyperdynamic state in cirrhosis is associated with limited oxygen consumption as compared with a control series of patients. Of the 14 patients who required operations, eight survived and six died. The mean indocyanine green clearance was a statistically significant predictor of death.
Ito
K
K
Department of Surgery, New York Medical College, Bronx, New York 10595.
Ramirez-Schon
G
G
Shah
P M
PM
Del Guercio
L R
LR
D000328:Adult; D002302:Cardiac Output; D002404:Catheterization; D002407:Catheterization, Swan-Ganz; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007208:Indocyanine Green; D008103:Liver Cirrhosis / Q000150:complications / Q000401:mortality / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010101:Oxygen Consumption; D011379:Prognosis; D011669:Pulmonary Wedge Pressure; D012044:Regression Analysis; D012720:Severity of Illness Index; D014655:Vascular Resistance
D007208:Indocyanine Green