Ovarian stimulation by exogenous gonadotrophins in fetal ethanol-exposed immature rats.
Adult pregnant rats were given either an ad libitum liquid diet containing 5% ethanol, a pair fed liquid diet or an ad libitum diet of rat chow and water administered throughout pregnancy and during the nursing period. The female offspring received either pregnant mare's serum gonadotrophin (PMSG) or PMSG followed by human chorionic gonadotrophin (hCG) at 30 days of age. The ovaries of fetal ethanol-exposed animals responded greater to the exogenous gonadotrophins with enhanced ovarian weights, increased numbers of ova shed, greater numbers of corpora lutea and antral follicles, and higher serum progesterone levels than in animals exposed to the control diets during gestation.
Rudeen
P K
PK
Department of Anatomy, University of Missouri School of Medicine, Columbia 65212.
Hagaman
J
J
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006064:Gonadotropins, Equine / Q000494:pharmacology; D009866:Oogenesis / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000196:embryology / Q000254:growth & development / Q000502:physiology*; D051381:Rats
D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D000431:Ethanol