title: Measurement of nocturnal body motility: behaviour of osteoarthritic patients and healthy controls.
abstract: Nocturnal body motility has been compared in a sleep laboratory between patients with osteoarthritis and healthy age-, sex- and weight-matched controls using a Bio-medical timer and bedleg force transducers connected to a Disa polygraph. Four motility variables were derived (duration of movement; duration adjusted for sensitivity; number of movements; number of 30-s epochs containing movements) enabling an assessment of nocturnal body motility in the two groups. There was a trend for osteoarthritic patients to move more than controls during sleep on all variables measured, although this did not reach statistical significance. Temazepam elixir (0.4 mg/kg body weight/night) reduced all four motility variables in both osteoarthritic patients and controls, although only the reduction of the number of 30-s epochs containing movements (P less than 0.05) in the control group attained statistical significance.
authors.affiliation: Regional Rheumatology Centre, Royal Bath Hospital, Harrogate, North Yorkshire, UK.
authors.forename: T J
authors.initials: TJ
authors.lastname: Leigh
authors.forename: H A
authors.initials: HA
authors.lastname: Bird
authors.forename: I
authors.initials: I
authors.lastname: Hindmarch
authors.forename: V
authors.initials: V
authors.lastname: Wright
mesh_terms: D000368:Aged; D002940:Circadian Rhythm; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000187:drug effects; D010003:Osteoarthritis / Q000188:drug therapy / Q000503:physiopathology*; D012016:Reference Values; D012890:Sleep / Q000187:drug effects; D012894:Sleep Stages / Q000187:drug effects; D013693:Temazepam / Q000627:therapeutic use
chemical_list: D013693:Temazepam