title: [New derivatives of 7-amino-2,3-polymethylenindole with anti-inflammatory activity].
abstract: Thirty-four new N-acylderivatives of 7-amino-2,3-polymethyleneinoles (I) and (II) were prepared and tested, together with a few analogues previously obtained, against carrageenan edema in the rat. Several compounds, at a dose of 1 mmole/kg, exhibit good inhibitory activity, that in some cases is superior to that displayed by indomethacin at a dose of 5 mg/kg. With only one exception, activity is confined to compounds of formula (I) and, generally, derivatives of 2,3-hexamethyleneindole are more active than those of lower homologues.
authors.affiliation: Istituto di Analitica Farmaceutica, Università di Sassari.
authors.forename: R
authors.initials: R
authors.lastname: Cerri
authors.forename: A
authors.initials: A
authors.lastname: Pau
authors.forename: G
authors.initials: G
authors.lastname: Boatto
authors.forename: F
authors.initials: F
authors.lastname: Sparatore
authors.forename: M
authors.initials: M
authors.lastname: Satta
authors.forename: F
authors.initials: F
authors.lastname: Capasso
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000893:Anti-Inflammatory Agents; D007211:Indoles
vernacular_title: Nuovi derivati di 7-ammino-2,3-polimetilenindoli ad attività antiinfiammatoria.