[Effect of benzonal on the drug-metabolizing function of the liver in pathological states].
In male rabbits with experimental acute hepatitis, acute renal insufficiency, diffuse peritonitis, Staphylococcus sepsis and thermic burns and also in patients with diseases of the nervous system one could observe prolongation of the half-elimination period (T1/2) and decrease of metabolic clearance of antipyrine. Benzonal (50 mg/kg orally for 3 days) normalized indices of antipyrine test. Similar results were obtained in patients with diseases of the nervous system (epilepsy, rheumatic vasculitis of the cerebral vessels with convulsive syndrome).
Nadzhimutdinov
K N
KN
Khakimov
Z Z
ZZ
D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics; D001463:Barbiturates / Q000494:pharmacology* / Q000627:therapeutic use; D001711:Biotransformation / Q000187:drug effects; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011817:Rabbits; D013997:Time Factors
D001463:Barbiturates; D000983:Antipyrine; C002915:benzobarbital
Vliianie benzonala na farmakometaboliziruiushchuiu funktsiiu pecheni pri nekotorykh patologicheskikh sostoianiiakh.