Effects of ifenprodil tartrate on vertebral, basilar and internal carotid arteries.
Changes in blood flow of vertebral and internal carotid arteries of rats after the administration of ifenprodil tartrate were measured using the transit-time ultrasonic volume flowmeter. Tension of isolated canine basilar and internal carotid arteries was also tested isometrically. Ifenprodil tartrate produced a sustained increase in both vertebral and internal carotid arterial blood flow of rat. The increase in blood flow was greater in vertebral than in internal carotid arteries. Papaverine hydrochloride transiently increased arterial blood flow in both the vertebral and internal carotid arteries to approximately the same extent. Ifenprodil tartrate induced dose-related relaxation in basilar and in internal carotid arteries contracted with K+ (50 mM), and its effects were greater in basilar than in internal carotid arteries, while relaxation induced by papaverine hydrochloride was about the same in both arteries. These results suggest that the significant increase of vertebral arterial blood flow induced by ifenprodil tartrate is due to the peculiarity of vascular myorelaxation by this drug.
Honda
H
H
Department of Pharmacology, Tokyo Medical College, Japan.
Watanabe
Y
Y
Irino
O
O
Shimura
H
H
Shibuya
T
T
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects; D002339:Carotid Arteries / Q000187:drug effects; D004285:Dogs; D005260:Female; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*; D014711:Vertebral Artery / Q000187:drug effects
D010880:Piperidines; D014665:Vasodilator Agents; C010739:ifenprodil