title: Sister chromatid exchanges in the lymphocytes of control women, pregnant women, and women taking oral contraceptives: effects of cell culture temperature.
abstract: The incidence of sister chromatid exchange (SCE) was investigated in the lymphocytes of control women, pregnant women, and women using oral contraceptives after culture at 37 degrees C and 40 degrees C. At 37 degrees C, the mean frequency of SCE (MEAN +/- S.E.) was found to be 7.91 +/- 0.30 in pregnant women and 8.53 +/- 0.29 in oral contraceptive users which were significantly higher than the SCE value of 5.56 +/- 0.21 found in control women. Increase in growth temperature to 40 degrees C elevated the SCE frequency to 11.86 +/- 0.44 in pregnant women, 12.76 +/- 0.46 in oral contraceptive users and 7.24 +/- 0.26 in control women. These data indicate that there is a differential induction of SCEs following increased cell culture temperature in the lymphocytes of pregnant women and oral contraceptive users, compared with control women.
authors.affiliation: Department of Anthropology, University of Delhi, India.
authors.forename: R
authors.initials: R
authors.lastname: Ghosh
authors.forename: P K
authors.initials: PK
authors.lastname: Ghosh
mesh_terms: D002478:Cells, Cultured; D003276:Contraceptives, Oral / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008214:Lymphocytes; D011247:Pregnancy; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013696:Temperature
chemical_list: D003276:Contraceptives, Oral