Subcutaneous polymeric matrix system poly(HEMA-BGA) for controlled release of an anticancer drug (5-fluorouracil). I. Synthesis and structure.
The present study was an attempt to design a new polymer-drug composite system for local chemotherapy. Poly(hydroxyethylmethacrylate-bisglycolacrylate) carriers containing an anticancer drug, 5-fluorouracil, were prepared by low temperature radiation polymerization technique. By changing the relative amounts and the types of ingredients, drug loading and radiation dosage, polymer-drug composites with different structural properties were obtained. This paper presents the preparation procedure and analyses some of the structural properties of these novel composites.
Denizli
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A
Hacettepe University, Chemical Engineering Department, Ankara, Turkey.
Kiremitçi
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M
Pişkin
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D000179:Acrylates / Q000138:chemical synthesis*; D003692:Delayed-Action Preparations; D005472:Fluorouracil / Q000008:administration & dosage*; D007202:Indicators and Reagents; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D011102:Polyhydroxyethyl Methacrylate / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D011109:Polymethacrylic Acids / Q000138:chemical synthesis*
D000179:Acrylates; D003692:Delayed-Action Preparations; D007202:Indicators and Reagents; D011109:Polymethacrylic Acids; D011102:Polyhydroxyethyl Methacrylate; C056970:poly(hydroxyethylmethacrylate bisglycolacrylate); D005472:Fluorouracil