[Hypogonadotrophic hypogonadism and peripheral adrenal insufficiency in 2 brothers].
Two siblings with chronic adrenal insufficiency, diagnosed at 12 years of age, failed to show a spontaneous onset of puberty in spite of adequate adrenocortical therapy. Testosterone plasma levels were low, without concomitant increase in gonadotropin levels. This association strongly suggest a sex-linked cytomegalic adrenocortical hypoplasia.
Bessac
L
L
Service de médecine infantile, CHRU de Grenoble, France.
Bost
M
M
Bachelot
Y
Y
Andrini
P
P
D000309:Adrenal Insufficiency / Q000150:complications* / Q000151:congenital / Q000235:genetics; D002648:Child; D006062:Gonadotropins / Q000172:deficiency*; D006801:Humans; D007006:Hypogonadism / Q000150:complications*; D008297:Male; D011628:Puberty, Delayed / Q000209:etiology
D006062:Gonadotropins
Hypogonadisme hypogonadotrophique et insuffisance surrénale périphérique chez deux frères.