[The ability of cestodes to synthesize serotonin].
The ability of the parasitic flat worms Hymenolepis diminuta and Mesocestoides corti to synthetize serotonin (5-HT) has been investigated by means of incubation the worms in metabolic precursor of 5-HT, L-tryptophan, and monoamineoxidase inhibitor, indopan, followed by spectrofluorimetric determination of the tissue level of 5-HT. To avoid possible inhibition of 5-HT synthesis by exogenous 5-HT of the host, experiments were carried out on worms in which the level of 5-HT was previously decreased by reserpine. The increase in the level of 5-HT in tissues after incubation of the worms in L-tryptophan and indopan was observed, indicating their ability to synthetize serotonin from tryptophan.
Terenina
N B
NB
Shalaeva
N M
NM
Pomogaev
I N
IN
D000818:Animals; D002589:Cestoda / Q000378:metabolism*; D006926:Hymenolepis / Q000187:drug effects / Q000378:metabolism*; D007814:Larva / Q000187:drug effects / Q000378:metabolism; D008645:Mesocestoides / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000032:analysis / Q000096:biosynthesis*; D014363:Tryptamines / Q000494:pharmacology; D014364:Tryptophan / Q000378:metabolism / Q000494:pharmacology
D008996:Monoamine Oxidase Inhibitors; D014363:Tryptamines; D012701:Serotonin; D012110:Reserpine; D014364:Tryptophan; C015293:indopan
Issledovanie sposobnosti tsestod sintezirovat' serotonin.