title: [Use of trental for correcting the pharmacological effects caused by voltaren and indomethacin].
abstract: Treatment of the adjuvant disease in rats by intragastric administration of voltaren or indomethacin (3 mg/kg) was followed by approximately equal anti-inflammatory and analgesic effects on the affected joints. In this case the development of active dystrophic changes in the gastrointestinal tract and kidneys was observed. At combined administration of the antiphlogistics with trental there was noted an enhancement of their therapeutic action on the joints and also a weakening of the ulcerogenic effect and nephrotoxicity that was reflected in the clinical, pathological, morphological and laboratory studies.
authors.forename: G I
authors.initials: GI
authors.lastname: Stepaniuk
authors.forename: N B
authors.initials: NB
authors.lastname: Lutsiuk
authors.forename: R P
authors.initials: RP
authors.lastname: Piskun
authors.forename: O V
authors.initials: OV
authors.lastname: Smirnova
authors.forename: M N
authors.initials: MN
authors.lastname: Cherviak
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy; D004008:Diclofenac / Q000009:adverse effects* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007213:Indomethacin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010431:Pentoxifylline / Q000627:therapeutic use*; D051381:Rats; D013805:Theobromine / Q000031:analogs & derivatives*
chemical_list: D004008:Diclofenac; D013805:Theobromine; D010431:Pentoxifylline; D007213:Indomethacin
vernacular_title: Primenenie trentala dlia korrektsii farmakologicheskikh éffektov, vyzvannykh vol'tarenom i indometatsinom.