title: Melanine value in the stria vascularis of pigmented guinea-pigs treated by kanamycin.
abstract: In a previous report, kanamycin (400 mg/kg/d) seemed to increase the number of melanine granulations in intermediate cells of the stria vascularis, especially in the second and third turns. To precise these data, melanine was studied in those turns by ultrastructural morphometry in a control group with 12 animals. We observed a large intra-individual and inter-individual variation before intoxication. Thus, the meaning of melanine modifications by kanamycin must be carefully evaluated.
authors.affiliation: ENT University Clinic, CHU of Grenoble, France.
authors.forename: A
authors.initials: A
authors.lastname: Attard
authors.forename: B
authors.initials: B
authors.lastname: Gratacap
authors.forename: R
authors.initials: R
authors.lastname: Charachon
authors.forename: P
authors.initials: P
authors.lastname: Stoebner
authors.forename: A
authors.initials: A
authors.lastname: Laurent
mesh_terms: D000818:Animals; D003051:Cochlea / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000378:metabolism; D006168:Guinea Pigs; D007612:Kanamycin / Q000633:toxicity*; D008297:Male; D008543:Melanins / Q000378:metabolism*; D008854:Microscopy, Electron; D013316:Stria Vascularis / Q000378:metabolism*
chemical_list: D008543:Melanins; D007612:Kanamycin