title: Pathology of laser-induced experimental aneurysms.
abstract: Aneurysms were produced in the common carotid artery of 35 rats by milliwatt CO2 laser welding of an adventitia patch over a hole. The aneurysmal sac was formed by collagen; the lumen was covered by an endothelial-like lining and partially thrombosed. The pathology of these aneurysms is similar to spontaneously occurring intracranial human aneurysms. This aneurysm model has properties (reliability, spontaneous bleeding tendency, minimal vessel manipulation, and pathological features) that make it theoretically advantageous for the induction of experimental intracranial aneurysms in larger animals.
authors.affiliation: Division of Neurosurgery, Northwestern University Medical School, Chicago.
authors.forename: M
authors.initials: M
authors.lastname: Ammirati
authors.forename: H
authors.initials: H
authors.lastname: Ostertag
authors.forename: E
authors.initials: E
authors.lastname: Rabin
authors.forename: I
authors.initials: I
authors.lastname: Ciric
mesh_terms: D000783:Aneurysm / Q000209:etiology / Q000473:pathology*; D000818:Animals; D002339:Carotid Arteries / Q000601:surgery*; D002340:Carotid Artery Diseases / Q000209:etiology / Q000473:pathology*; D003094:Collagen; D003238:Connective Tissue / Q000601:surgery; D004195:Disease Models, Animal; D053685:Laser Therapy; D008866:Microsurgery; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003094:Collagen