title: [Changes in the indices of central hemodynamics and myocardial metabolism as affected by plasmapheresis in patients with myocardial infarct].
abstract: Gravitation plasmapheresis (PP) on PF-0.5 fractionator was used in 32 patients with acute myocardial infarction to control blood rheologic disorders. Central hemodynamics and myocardial metabolism were monitored by means of right heart probing and echocardiography. A control group of 7 patients were subjected to "mock PP" with a rheopolyglucin infusion. PP limited manifestations of heart failure, normalized the levels of compounds with high molecular weights which conditioned plasma viscosity, reduced significantly total peripheral and total pulmonary resistance, increased the cardiac index, stroke volume and ejection fraction, and improved regional left-ventricular contractility. Myocardial metabolic studies demonstrated a decline in left-ventricular myocardial ischemia, as evidenced by the arteriovenous difference in lactate levels. It is therefore suggested that PP can be effectively used as part of combined treatment for complicated acute myocardial infarction.
authors.forename: S P
authors.initials: SP
authors.lastname: Grachev
authors.forename: M V
authors.initials: MV
authors.lastname: Orlov
authors.forename: S S
authors.initials: SS
authors.lastname: Lekokhmakher
authors.forename: A O
authors.initials: AO
authors.lastname: Gavrilov
authors.forename: V V
authors.initials: VV
authors.lastname: Chestukhin
mesh_terms: D000368:Aged; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000378:metabolism*; D010956:Plasmapheresis
vernacular_title: Izmeneniia pokazateleĭ tsentral'noĭ gemodinamiki i metabolizma miokarda pod vozdeĭstviem plazmafereza u bol'nykh infarktom miokarda.