title: Local steroid application for hyperplastic dystrophy of the vulva. Clinical and pathologic evaluation.
abstract: Fifteen women complaining of vulvar pruritus of at least three months' duration were evaluated clinically and noted to have white lesions of the vulva consistent with hyperplastic dystrophy. Histologic evaluation confirmed the diagnosis, and all the patients were treated with local application of halocidine cream and crotamiton cream. After six weeks of therapy a repeat clinical and histologic evaluation revealed 13 of the 15 patients to be completely relieved of the vulvar pruritus, and 12 of the 13 were histologically demonstrated to have complete reversal of the hyperplastic process to normal skin. The other two denied any improvement in their pruritus and were histologically noted to have persistence of the hyperplastic process. A good clinical and histologic correlation was noted following local steroid application in patients with histologically proven hyperplastic dystrophy.
authors.affiliation: Department of Obstetrics and Gynecology, Harbor-University of California, Los Angeles School of Medicine.
authors.forename: A
authors.initials: A
authors.lastname: Bergman
authors.forename: M
authors.initials: M
authors.lastname: Karram
authors.forename: N N
authors.initials: NN
authors.lastname: Bhatia
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008875:Middle Aged; D009824:Ointments; D013256:Steroids / Q000008:administration & dosage / Q000627:therapeutic use*; D014052:Toluidines / Q000008:administration & dosage / Q000627:therapeutic use*; D014845:Vulvar Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D009824:Ointments; D013256:Steroids; D014052:Toluidines; C005553:crotamiton