Citric, malic and succinic acids as possible alternatives to deferoxamine in aluminum toxicity.
The effect of repeated intraperitoneal administration of deferoxamine, citric, malic and succinic acids on the distribution and excretion of aluminum was determined in male Swiss mice which had previously received aluminum nitrate intraperitoneally at a daily dose of 0.27 mmol/kg for five weeks. Chelating agents were administered for two weeks at doses approximately equal to one-fourth of their respective LD50. Treatment with DFOA, citric, malic or succinic acids significantly increased the fecal and urinary excretion of aluminum and reduced the concentration of aluminum found in various organs and tissues, with citric acid being the most effective. In sight of these results, citric, malic or succinic acids may be considered as alternatives to deferoxamine in aluminum toxicity. However, further investigations are required previous to the possible use of these compounds in human aluminum poisoning.
Domingo
J L
JL
Laboratory of Toxicology & Biochemistry, School of Medicine, University of Barcelona, Reus, Spain.
Gómez
M
M
Llobet
J M
JM
Corbella
J
J
D000535:Aluminum / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D001923:Brain Chemistry; D002951:Citrates / Q000008:administration & dosage / Q000627:therapeutic use*; D019343:Citric Acid; D003676:Deferoxamine / Q000627:therapeutic use*; D005243:Feces / Q000032:analysis; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008293:Malates / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D013386:Succinates / Q000008:administration & dosage / Q000627:therapeutic use*; D019802:Succinic Acid
D002951:Citrates; D008293:Malates; D013386:Succinates; D019343:Citric Acid; C030298:malic acid; D019802:Succinic Acid; D000535:Aluminum; D003676:Deferoxamine