Bilirubin, intraventricular hemorrhage, and phenobarbital in very low birth weight babies.
The relationships among serum bilirubin concentration on days 5 and 7, birth weight, the presence of intraventricular hemorrhage, and the receipt of phenobarbital were examined in a group of 232 newborns weighing less than 1,751 g who were intubated, mechanically ventilated by 12 hours after birth, and whose parents had given permission for a randomized trial of phenobarbital prophylaxis of intraventricular hemorrhage. The ratio of serum bilirubin concentration to birth weight (the bilirubin divided by birth weight index [BBI]) was used to examine the impact of 25 variables on a clinical guideline for therapy of hyperbilirubinemia in newborn infants. A linear regression model was used; the most powerful covariate was a birth weight less than 1.0 kg. The only other variable that reduced the BBI was phenobarbital receipt. The presence of intraventricular hemorrhage and ecchymoses had a significant influence increasing the BBI.
Epstein
M F
MF
Department of Newborn Medicine, Brigham and Women's Hospital, Boston, MA.
Leviton
A
A
Kuban
K C
KC
Pagano
M
M
Meltzer
C
C
Skouteli
H N
HN
Brown
E R
ER
Sullivan
K F
KF
D001663:Bilirubin / Q000097:blood*; D001724:Birth Weight; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000517:prevention & control; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D010634:Phenobarbital / Q000627:therapeutic use*
D001663:Bilirubin; D010634:Phenobarbital