title: Improvement of immunologic abnormalities associated with hyperthyroidism of Graves' disease during methimazole treatment.
abstract: In an attempt to study the effects of methimazole treatment on immunologic abnormality of hyperthyroidism of Graves' disease, TSH receptor antibody (TRab), anti-DNA antibody and HLA-DR were measured in untreated patients with hyperthyroidism of Graves' disease and treated patients with methimazole for 2 years, using peripheral blood. In untreated patients, all 3 parameters elevated above normal. Three parameters decreased 2 years after methimazole treatment, but the magnitude of decrease was more in T3-suppressible patients than in T3-unsuppressible patients. However, both anti-DNA antibody and HLA-DR were significantly more in T3-suppressible patients than in normal subjects. It is suggested that immunologic abnormalities should largely be improved before remission of Graves' disease can be obtained.
authors.affiliation: Department of Gerontology, Endocrinology and Metabolism, School of Medicine, Shinshu University, Matsumoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: Y
authors.initials: Y
authors.lastname: Koizumi
authors.forename: T
authors.initials: T
authors.lastname: Aizawa
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Ishihara
authors.forename: Y
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: H
authors.initials: H
authors.lastname: Ogata
authors.forename: K
authors.initials: K
authors.lastname: Kamoi
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
mesh_terms: D000293:Adolescent; D000328:Adult; D004247:DNA / Q000276:immunology; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D008297:Male; D008713:Methimazole / Q000627:therapeutic use*; D008875:Middle Aged; D011988:Receptors, Thyroid Hormone / Q000187:drug effects / Q000378:metabolism; D013972:Thyrotropin / Q000378:metabolism; D014284:Triiodothyronine / Q000097:blood
chemical_list: D006680:HLA Antigens; D011988:Receptors, Thyroid Hormone; D014284:Triiodothyronine; D008713:Methimazole; D013972:Thyrotropin; D004247:DNA