A novel CaCl2 continuous infusion screening method for antiarrhythmic and/or calcium antagonist drugs in rat.
The authors describe a new method to screen antiarrhythmics drugs by continuous infusion of calcium chloride in albino rat. Results are compared with those of a single injection method. Three reference compounds were tested: verapamil, nifedipine and trimetazidine. Verapamil and trimetazidine were shown to be equally active by the two methods. A fourth compound, synthetized in the laboratory, was active in the various arrhythmia models and, in particular, in the novel model described.
Vaille
A
A
Laboratoire de Pharmacodynamie, U.E.R. de Pharmacie de Marseille, France.
Scotto di Tella
A M
AM
Vanalle
P
P
Maldonado
J
J
D000758:Anesthesia; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers; D002122:Calcium Chloride / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical; D006339:Heart Rate / Q000187:drug effects; D007262:Infusions, Intravenous; D051381:Rats; D011919:Rats, Inbred Strains
D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D002122:Calcium Chloride