Enhanced faecal excretion of 2,3,4,7,8-pentachlorodibenzofuran in rats by a long-term treatment with activated charcoal beads.
1. The effect of activated charcoal beads on the faecal excretion of 2,3,4,7,8-pentachlorodibenzofuran (PenCDF), a causal agent of yusho, which accumulates in the body, was studied for 12 weeks in rats. 2. Diets supplemented with 1% and 5% activated charcoal beads stimulated faecal excretion of PenCDF about 2- and 4-fold, respectively. The concentration of PenCDF in liver, the major storage site, was decreased significantly and dose-dependently by the treatment. 3. The charcoal bead treatment decreased the extent of fatty liver, thymic atrophy, and induction of hepatic benzo[a]pyrene hydroxylase.
Kamimura
H
H
Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Koga
N
N
Oguri
K
K
Yoshimura
H
H
Honda
Y
Y
Nakano
M
M
D000818:Animals; D001572:Benzofurans / Q000493:pharmacokinetics*; D002606:Charcoal; D002849:Chromatography, Gas; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D005243:Feces / Q000032:analysis*; D008099:Liver / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001572:Benzofurans; D002606:Charcoal; C038890:2,3,4,7,8-pentachlorodibenzofuran