Inhibition of Chlamydia trachomatis growth by recombinant tumor necrosis factor.
Purified human recombinant tumor necrosis factor (rTNF) alpha inhibited the growth of Chlamydia trachomatis (L2/434/Bu) in HEp-2 cell cultures. The inhibition of C. trachomatis yield could be achieved even when the rTNF alpha (200 ng/ml) was added up to 12 h after infection. The effect of rTNF alpha on chlamydial infection was synergistic with that of gamma interferon.
Shemer-Avni
Y
Y
Virology Unit, Faculty of Health Sciences, Ben-Gurion University, Beer Sheva, Israel.
Wallach
D
D
Sarov
I
I
D002277:Carcinoma / Q000382:microbiology; D002460:Cell Line; D002690:Chlamydia Infections / Q000517:prevention & control; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000254:growth & development; D006131:Growth Inhibitors / Q000494:pharmacology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000382:microbiology; D011994:Recombinant Proteins / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D006131:Growth Inhibitors; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha