title: Dopamine enhances the neuronal activity of spatial short-term memory task in the primate prefrontal cortex.
abstract: The influence of dopamine and its antagonists on neuronal activity related to the delay period of a delayed response task was examined in the monkey prefrontal cortex. Iontophoretically applied dopamine enhanced the delay-related neuronal activity, while fluphenazine and haloperidol attenuated the activity. Sulpiride had no effect on the activity. The results suggest that dopamine promotes processing of spatial short-term memory by increasing memory-related activity in the primate prefrontal cortex, probably via D1-type dopamine receptor.
authors.affiliation: Department of Neurophysiology, Kyoto University, Inuyama City, Aichi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sawaguchi
authors.forename: M
authors.initials: M
authors.lastname: Matsumura
authors.forename: K
authors.initials: K
authors.lastname: Kubota
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D003216:Conditioning, Operant; D004298:Dopamine / Q000494:pharmacology*; D008251:Macaca; D008570:Memory, Short-Term / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*
chemical_list: D004298:Dopamine