title: Hypovolemic shock, pancreatic blood flow, and pancreatitis.
abstract: Electromagnetic blood flow determinations were carried out on the superior pancreatic duodena (SPDA), the splenic (SA) and the superior mesenteric (SMA) arteries and compared to cardiac output (CO, thermodilution technique) in 12 anesthetized dogs submitted to hypovolemic shock of various duration: 5 dogs underwent a one-hour and 7 a three-hour period of shock. A 50 mm Hg level of mean arterial blood pressure (MABP) was maintained throughout hypovolemia. Dogs were then reinfused. Control preshock values were 4.12 l/min for CO, 38.0 ml/min for SPDA, 405.9 ml/min for SA, and 963.6 ml/min for SMA. SPDA, SA and SMA flows expressed as % of CO amounted to 0.9, 9.8 and 23.4% respectively. No significant changes in SPDA and SMA flows were noted within the first hour of shock. However, from the end of the second hour on, both flows differed significantly (P less than 0.01), SMA increasing from -75.6% of its control value at the end of bleeding to -61.0%, and SPDA decreasing from -75.6 to -86.9%. Similar observations were made when respective flows were considered as % of CO. The SA behaved somewhat in an intermediate fashion. This relative spoliation in pancreatic blood supply as hypovolemia proceeds supports an ischemic etiology of acute pancreatitis (AP), which could account for some of the so-called idiopathic cases of AP.
authors.affiliation: Pancreatic Research Laboratory, Mount Sinai School of Medicine, CUNY 10029.
authors.forename: J H
authors.initials: JH
authors.lastname: Robert
authors.forename: A E
authors.initials: AE
authors.lastname: Toledano
authors.forename: L S
authors.initials: LS
authors.lastname: Toth
authors.forename: G
authors.initials: G
authors.lastname: Premus
authors.forename: D A
authors.initials: DA
authors.lastname: Dreiling
mesh_terms: D000818:Animals; D002302:Cardiac Output; D004285:Dogs; D055590:Electromagnetic Phenomena; D005260:Female; D010179:Pancreas / Q000098:blood supply*; D010195:Pancreatitis / Q000150:complications*; D012039:Regional Blood Flow; D012769:Shock / Q000150:complications*