title: Insulin-dependent diabetes mellitus, myasthenia gravis, pernicious anaemia, autoimmune thyroiditis and autoimmune adrenalitis in a single patient.
abstract: Two classical autoimmune polyendocrine deficiency syndromes with heritable tendencies are described, Type 1 diabetes mellitus being associated with the Type 2 polyendocrine deficiency syndrome (Schmidt's syndrome). A man with Type 1 diabetes mellitus is described who developed an unusual combination of five autoimmune conditions (myasthenia gravis, Addisonian pernicious anaemia, adrenalitis and thyroiditis) which did not fit into the Type 1 or Type 2 classical polyendocrine deficiency syndromes. This suggests that the autoantibody, biochemical and haematological screening of affected individuals and their relatives should be extended to anticipate a wider range of potential autoimmune conditions.
authors.affiliation: University of Glasgow Department of Materia Medica, Stobhill General Hospital.
authors.forename: S T
authors.initials: ST
authors.lastname: Green
authors.forename: J P
authors.initials: JP
authors.lastname: Ng
authors.forename: D
authors.initials: D
authors.lastname: Chan-Lam
mesh_terms: D000307:Adrenal Gland Diseases / Q000150:complications*; D000752:Anemia, Pernicious / Q000150:complications*; D001327:Autoimmune Diseases; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D006801:Humans; D007249:Inflammation / Q000150:complications; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications*; D013967:Thyroiditis, Autoimmune / Q000150:complications*