Debrisoquin oxidation polymorphism in a Spanish population.
The capacity for debrisoquin metabolism was determined in 377 healthy Spanish volunteers by measuring the amount of debrisoquin and its main metabolite, 4-hydroxydebrisoquin, in urine after an oral dose of debrisoquin. Debrisoquin oxidation was polymorphic, with 25 subjects (6.6%) phenotyped as poor metabolizers whereas 352 subjects (93.4%) were classified as extensive metabolizers. The metabolic ratio between debrisoquin and 4-hydroxydebrisoquin (percent of dose) in 6-hour urine samples ranged from 0.03 in extensive metabolizers to 93.5 in poor metabolizers. The proportion of poor metabolizers found is in the range observed in other white populations studied.
Benítez
J
J
Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain.
LLerena
A
A
Cobaleda
J
J
D000293:Adolescent; D000328:Adult; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D007546:Isoquinolines / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010641:Phenotype; D013030:Spain
D007527:Isoenzymes; D007546:Isoquinolines; C012359:4-hydroxydebrisoquin; D003577:Cytochrome P-450 Enzyme System; D003647:Debrisoquin