title: Plasma cell leukemia with IgA paraproteinemia and hyperviscosity.
abstract: Primary IgA plasma cell leukemia is a rare disorder in which hyperviscosity has not been reported. We studied a patient with plasma cell leukemia and IgA lambda monoclonal gammopathy with an elevated relative serum viscosity and congestive heart failure. Plasmapheresis and chemotherapy were successful in controlling symptoms. We discuss this unusual association and review the literature.
authors.affiliation: Department of Medicine, UCLA School of Medicine 90024.
authors.forename: M A
authors.initials: MA
authors.lastname: Kosmo
authors.forename: R P
authors.initials: RP
authors.lastname: Gale
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D001809:Blood Viscosity; D003520:Cyclophosphamide / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D006333:Heart Failure / Q000150:complications / Q000628:therapy; D006801:Humans; D007070:Immunoglobulin A; D007952:Leukemia, Plasma Cell / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications*; D010956:Plasmapheresis; D011241:Prednisone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D007070:Immunoglobulin A; D003561:Cytarabine; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone