[Reaction of deamination of monoamines in the brain and heart of rats under the toxic action of hyperbaric oxygenation].
Kinetic parameters of monoamine deamination processes in the rat brain and heart after hyperbaric oxygenation (HBO) in toxic conditions (6 ata) were studied. HBO was shown to cause a substantial reduction in MAO affinity to serotonin in the brain, but not in the heart. Contrastingly, MAO affinity to dopamine was found to decrease in the heart, but not in the brain in response to HBO. Differences of tyramine and 2-phenylethylamine deamination in the rat brain and heart were also reciprocal following toxic HBO. In the initial phase of seizure episode MAO activity in the brain and heart was also different. Distinct mechanisms of adaptation to toxic oxygen in the central nervous system and cardiovascular system are discussed.
Gankina
E M
EM
Gol'dina
O A
OA
Shamakina
I Iu
IIu
Demurov
E A
EA
Koloskov
Iu B
IuB
D000818:Animals; D001921:Brain / Q000201:enzymology*; D003641:Deamination; D004298:Dopamine; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology*; D010627:Phenethylamines; D051381:Rats; D012701:Serotonin; D014439:Tyramine
D010627:Phenethylamines; C029261:phenethylamine; D012701:Serotonin; D008995:Monoamine Oxidase; D004298:Dopamine; D014439:Tyramine
Reaktsiia dezaminirovaniia monoaminov v mozge i serdtse krys pri toksicheskom deĭstvii giperbaricheskoĭ oksigenatsii.