title: [Bis-(N,N'-uracil-1-yl)-selenoxomethane: an inhibitor of the influenza virus].
abstract: Experimental studies of the influence of bis-(N,N'-uracil-1-yl)-selenoxomethane (I) and sodium selenite (II) on influenza virus reproduction on pieces of chorioallantoic membrane, both alone and in combination with remantadine and ribavirin, were carried out. The antiviral effects of both preparations were found to be enhanced in combination with effective and ineffective remantadine concentrations, whereas with ribavirin the additive effect was observed only in combination of the former preparation with ribavirin effective concentration. Combination of ribavirin with sodium selenite did not enhance the antiviral effect of the latter even when the effective concentration of nucleoside was used.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Lazymova
authors.forename: T A
authors.initials: TA
authors.lastname: Asadullaev
authors.forename: E Sh
authors.initials: ESh
authors.lastname: Mamedov
authors.forename: R Ia
authors.initials: RIa
authors.lastname: Akhverdieva
mesh_terms: D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002642:Chick Embryo; D004357:Drug Synergism; D005472:Fluorouracil / Q000494:pharmacology; D009980:Influenza A virus / Q000187:drug effects* / Q000502:physiology; D009942:Organometallic Compounds / Q000494:pharmacology*; D016566:Organoselenium Compounds; D012254:Ribavirin / Q000494:pharmacology; D012299:Rimantadine / Q000494:pharmacology; D020887:Selenious Acid; D012643:Selenium / Q000494:pharmacology; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000963:Antimetabolites; D000998:Antiviral Agents; D009942:Organometallic Compounds; D016566:Organoselenium Compounds; D012299:Rimantadine; C056973:bis-(N,N'-uracil-1-yl)selenoxomethane; D012254:Ribavirin; D014498:Uracil; D020887:Selenious Acid; D012643:Selenium; D005472:Fluorouracil
vernacular_title: Bis-(N,N'-uratsil-1-il)-selenoksometan: ingibitor virusa grippa.