[Alcohol-drug interaction in rat embryogenesis: the effect of separate and combined action of sodium salicylate and ethanol].
A combined administration of sodium salicylate and ethanol to female rats in threshold embryotoxic doses on the 9th, 10th, 12th and 13th days of pregnancy results in a sharp increase of embryolethal and teratogenic effects. The embryotoxic effect of sodium salicylate and ethanol at their combined injection exceeds the summational embryotoxic effect at the separate action of the preparations. The spectrum of malformations after their combined effect does not differ from that induced with sodium salicylate.
Chebotar'
N A
NA
Tikhodeeva
I I
II
Konopistseva
L A
LA
Dzhandzhaliia
A M
AM
Puchkov
V F
VF
D000014:Abnormalities, Drug-Induced; D000818:Animals; D004357:Drug Synergism; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D005865:Gestational Age; D011247:Pregnancy; D051381:Rats; D012980:Sodium Salicylate / Q000008:administration & dosage / Q000009:adverse effects*
D000431:Ethanol; D012980:Sodium Salicylate
Alkogol'-lekarstvennye vzaimodeĭstviia v émbriogeneze krys: vliianie razdel'nogo i sovmestnogo deĭstviia salitsilovokislogo natriia i étanola.