Subchronic neurotoxicity in rats of the structural fumigant, sulfuryl fluoride.
Inhalation exposure of male and female Fischer 344 rats to sulfuryl fluoride [Vikane (Dow Chemical Company) gas fumigant] at 300 ppm for 6 hr/day, 5 days week, for 13 weeks caused diminished weight gain, dental fluorosis, a slight decrease in grooming, decreased flicker fusion threshold, slowing of flash, auditory and somatosensory evoked potentials, mild nasal and pulmonary inflammation, mild kidney effects, and mild vacuolation in the brain. Auditory brainstem responses (ABRs) and brain histology were evaluated two months postexposure in 2 male and 2 female rats. Both the ABRs and brain histology were within normal limits at this time, indicating that these treatment effects were, to at least a great extent, reversible. Exposure to 100 ppm resulted in dental fluorosis and very minor slowing of some evoked responses; all other measures, including brain histology, were normal. No treatment effects were noted at 30 ppm.
Mattsson
J L
JL
Health and Environmental Sciences, Dow Chemical Co., Midland, MI 48674.
Albee
R R
RR
Eisenbrandt
D L
DL
Chang
L W
LW
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001300:Audiometry, Evoked Response; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005260:Female; D005425:Flicker Fusion / Q000187:drug effects; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009420:Nervous System / Q000187:drug effects*; D051381:Rats; D011916:Rats, Inbred F344; D012737:Sex Factors; D013441:Sulfinic Acids / Q000633:toxicity*
D007306:Insecticides; D013441:Sulfinic Acids; C048899:sulfuryl fluoride