title: Suppression of hepatic HMG-CoA reductase activity by beta-muricholic acid in mice fed a diet containing cholesterol and cholic acid.
abstract: A diet containing cholesterol and cholic acid (SID) is known to induce the formation of cholesterol fatty liver as well as cholesterol gallstones. The activity of HMG-CoA reductase, one of the key enzymes for cholesterol synthesis in the liver, is significantly lowered by addition of beta-muricholic acid to SID. The prevention of fatty liver formation by beta-muricholic acid was accompanied by the suppression of HMG-CoA reductase activity.
authors.affiliation: Department of Pharmacology, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Fujino
authors.forename: K
authors.initials: K
authors.lastname: Nakayama
authors.forename: K
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Y
authors.initials: Y
authors.lastname: Furuya
authors.forename: T
authors.initials: T
authors.lastname: Yonaga
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D002793:Cholic Acids / Q000494:pharmacology*; D004032:Diet; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects
chemical_list: D002791:Cholesterol, Dietary; D002793:Cholic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; C004821:muricholic acid; D002784:Cholesterol