title: Anticardiolipin antibodies in patients with primary immunodeficiency diseases.
abstract: The presence of antibodies to cardiolipin was determined (by an ELISA) in 143 patients with primary immunodeficiency diseases. Thirty (21%) had raised anticardiolipin antibody levels compared with only three in 98 age matched controls. The highest prevalence of this autoantibody was found in the Wiskott-Aldrich syndrome. Patients with selective IgA deficiency also showed a high prevalence of this autoantibody (32%), while patients with severe defects in antibody production showed a low prevalence or did not have such autoantibodies. This study provides further evidence of the association between autoimmune phenomena and primary immunodeficiency diseases.
authors.affiliation: Department of Laboratory Medicine, Hospital la Paz, Madrid, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Pascual-Salcedo
authors.forename: M C
authors.initials: MC
authors.lastname: García Rodríguez
authors.forename: M
authors.initials: M
authors.lastname: López Trascasa
authors.forename: G
authors.initials: G
authors.lastname: Fontán
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D002308:Cardiolipins / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D017098:IgA Deficiency; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007223:Infant; D008875:Middle Aged
chemical_list: D001323:Autoantibodies; D002308:Cardiolipins