title: Amino acid requirements of Staphylococcus aureus strains from Germany and Austria that produce toxic shock syndrome toxin-1 (TSST-1).
abstract: Amino acid requirements of 156 toxic shock syndrome toxin-1 (TSST-1) producing Staphylococcus aureus strains from Germany and 37 strains from Austria have been determined. They were compared with TSST-1 negative S. aureus. Most of the strains required proline and valine with no significant differences between TSST-1 positive and negative S. aureus. There was no correlation between tryptophan auxotypy and TSST-1 producing strains. On complete chemically defined medium good bacterial growth was usually observed. Nevertheless, many strains stopped toxin production under these conditions. S. aureus strains with TSST-1 synthesis on complete medium required phenylalanine and cysteine for TSST-1 production mainly.
authors.affiliation: Institut für Hygiene und Medizinische Mikrobiologie, Fakultät für Klinische Medizin, Mannheim der Universität Heidelberg.
authors.forename: N
authors.initials: N
authors.lastname: Dickgiesser
authors.forename: P
authors.initials: P
authors.lastname: Eppli
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D001317:Austria; D001427:Bacterial Toxins; D004768:Enterotoxins / Q000096:biosynthesis*; D005860:Germany, West; D006801:Humans; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000254:growth & development* / Q000302:isolation & purification; D018089:Superantigens
chemical_list: D000596:Amino Acids; D001427:Bacterial Toxins; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal