[Change in potassium ion homeostasis of the crystalline lens in mice with hereditary cataracts (the CatFr line)].
Fraeser mouse lens morphology and potassium homeostasis were studied. It was shown that just at the age of one month mouse lens exposed "bull" cells which could be observed in patients with senile cataract as well. Nucleated fusiform extended cells were found 4 months later in the central part of the lens which was not typical for this part of the whole normal lens. Studied homogenates of 34 mice with hereditary cataract demonstrated statistically significant increase (1.5-fold about) in K+-content estimated for the whole lens weight as compared to the control group (38 lens). The difference in potassium content in aqueous humor between affected and control animals was statistically indistinguishable. The role of potassium ions in Fraeser cataract pathogenesis is discussed.
Kupriianova
E V
EV
Veroman
S A
SA
Formaziuk
V E
VE
Sergienko
V I
VI
Vladimirov
Iu A
IuA
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D002386:Cataract / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006706:Homeostasis; D007477:Ions; D007908:Lens, Crystalline / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains; D011188:Potassium / Q000378:metabolism*
D007477:Ions; D011188:Potassium
Izmenenie ionnogo gomeostaza kaliia v khrustalke u mysheĭ s nadsledstvennoĭ kataraktoĭ (liniia CatFr).