Correlations between cis-platinum dosage and toxicity in a guinea pig model.
A guinea pig model was used to study correlations between cis-platinum dosage and level of hearing loss, hair cell loss in the cochlea. Other parameters measured included weight loss and serum urea, creatinine, and cis-platinum levels. The damage to the inner ear expressed as hearing loss and hair cell loss demonstrated a highly positive correlation with the dosage of cis-platinum, and only a moderately positive correlation with the cis-platinum serum levels. Weight loss correlated well with hearing loss.
Hoeve
L J
LJ
ENT Department, Erasmus University, Rotterdam, The Netherlands.
Mertens zur Borg
I R
IR
Rodenburg
M
M
Brocaar
M P
MP
Groen
B G
BG
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage* / Q000097:blood / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects; D034381:Hearing Loss / Q000139:chemically induced*; D006316:Hearing Loss, High-Frequency / Q000139:chemically induced* / Q000473:pathology; D007263:Infusions, Parenteral; D008297:Male; D009925:Organ of Corti / Q000187:drug effects* / Q000473:pathology
D002945:Cisplatin