title: Teflon injection in female stress incontinence. Effect on urethral pressure profile and flow rate.
abstract: Thirty-six females with genuine stress incontinence (GSI) were treated by bladder neck teflon injection. Urethral pressure profilometry (UPP) and uroflowmetry were performed both pre- and post-operatively on 18 patients. In 24 patients who were either completely cured or improved by this procedure, the mean urine flow rate was reduced by 23% and the mean functional profile length increased by 9% compared with pre-operative values. Although these findings appear to explain the mechanism by which teflon improves continence, these differences were not statistically significant. Fourteen of the 18 patients who had not responded to previous anti-incontinence procedures were successfully treated by teflon injection. The improved response rate in these patients was not statistically significant. It was not possible to predict with certainty those patients most likely to respond to teflon injection. However, in women with normal or near normal pelvic floor anatomy the procedure had an acceptable success rate. In view of the simplicity, lack of morbidity and the ease with which it can be performed and repeated, bladder neck teflon injection deserves consideration as an alternative, particularly where open surgery has failed.
authors.affiliation: Department of Urology, Musgrove Park Hospital, Taunton.
authors.forename: S G
authors.initials: SG
authors.lastname: Vesey
authors.forename: A
authors.initials: A
authors.lastname: Rivett
authors.forename: P J
authors.initials: PJ
authors.lastname: O'Boyle
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008875:Middle Aged; D011138:Polytetrafluoroethylene / Q000008:administration & dosage*; D011312:Pressure; D014521:Urethra / Q000503:physiopathology; D001743:Urinary Bladder; D014550:Urinary Incontinence, Stress / Q000503:physiopathology / Q000628:therapy*; D014563:Urodynamics
chemical_list: D011138:Polytetrafluoroethylene