Steroid regulation of kidney histidine decarboxylase and ornithine decarboxylase levels in mouse kidney: effects of the mutation testicular feminization, Tfm.
1. Testosterone represses kidney histidine decarboxylase levels in both normal male and female mice. Tfm/Y mutant mice lack an androgen receptor and are phenotypically female. It has been suggested that the testosterone induction of HDC levels in these animals is a result of aromatisation to oestrogens in the absence of the androgen receptor; the oestrogens then induce the enzyme. 2. It is shown that the induction of HDC in Tfm/Y mice is specific to testosterone and not other androgens and can be mimiced by low doses of beta-oestradiol in normal female mice. 3. Analysis of Tfm/+ mice indicates that the testosterone induction effect is a function of individual kidney cells.
Middleton
R J
RJ
AFRC Institute of Animal Physiology and Genetics, Edinburgh Research Station, Scotland, UK.
Bulfield
G
G
D013734:Androgen-Insensitivity Syndrome / Q000201:enzymology*; D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D004790:Enzyme Induction; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006640:Histidine Decarboxylase / Q000096:biosynthesis / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009955:Ornithine Decarboxylase / Q000096:biosynthesis / Q000378:metabolism*; D013045:Species Specificity; D013739:Testosterone / Q000494:pharmacology*
D000728:Androgens; D004967:Estrogens; D013739:Testosterone; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase; D006640:Histidine Decarboxylase