[New derivatives of 7-amino-2,3-polymethylenindole with anti-inflammatory activity].
Thirty-four new N-acylderivatives of 7-amino-2,3-polymethyleneinoles (I) and (II) were prepared and tested, together with a few analogues previously obtained, against carrageenan edema in the rat. Several compounds, at a dose of 1 mmole/kg, exhibit good inhibitory activity, that in some cases is superior to that displayed by indomethacin at a dose of 5 mg/kg. With only one exception, activity is confined to compounds of formula (I) and, generally, derivatives of 2,3-hexamethyleneindole are more active than those of lower homologues.
Cerri
R
R
Istituto di Analitica Farmaceutica, Università di Sassari.
Pau
A
A
Boatto
G
G
Sparatore
F
F
Satta
M
M
Capasso
F
F
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D007211:Indoles
Nuovi derivati di 7-ammino-2,3-polimetilenindoli ad attività antiinfiammatoria.