Effect of repeated dermal application of endosulfan to rats.
Dermal application of endosulfan to male (18.75, 37.50 and 62.50 mg/kg/day) and female (9.83, 19.66 and 32.0 mg/kg/d) rats for 30 days produced hyperexcitability, tremor, dyspnea and salivation. There were no deaths. The signs of toxicity subsided after a week. Endosulfan produced no significant changes in the organ:body weight ratio. No significant changes were seen in the histological and hematological indices. However, a significant decrease in liver GOT and GPT and serum GPT activities and a significant rise in serum alkaline phosphatase and total protein were recorded in the endosulfan-treated animals. There were no changes in LDH. Residue analysis revealed higher levels of total endosulfan in fatty tissues of rats receiving the highest dose of endosulfan.
Dikshith
T S
TS
Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Raizada
R B
RB
Kumar
S N
SN
Srivastava
M K
MK
Kaushal
R A
RA
Singh
R P
RP
Gupta
K P
KP
D000818:Animals; D004726:Endosulfan / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D006948:Hyperkinesis / Q000139:chemically induced; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010573:Pesticide Residues / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012798:Sialorrhea / Q000139:chemically induced; D012869:Skin Absorption; D013737:Testis / Q000032:analysis; D014202:Tremor / Q000139:chemically induced
D010573:Pesticide Residues; D004726:Endosulfan