A major endogenous ligand substance involved in renal failure.
The clinical significance of a major endogenous ligand substance, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), present in the sera of patients with renal failure, was examined. In patients with chronic renal failure, the serum CMPF concentration was correlated with the serum creatinine concentration, but not in patients with acute renal failure. The accumulation of CMPF in the sera of patients with chronic renal failure may reflect the 'chronicity' of renal failure. Plasma exchange was more effective than direct hemoperfusion for the elimination of CMPF retained in uremic serum.
Mabuchi
H
H
Department of Internal Medicine and Nephrology, Nishijin Hospital, Kyoto, Japan.
Nakahashi
H
H
D058186:Acute Kidney Injury / Q000097:blood* / Q000628:therapy; D003404:Creatinine / Q000097:blood; D005663:Furans; D006464:Hemoperfusion; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D010951:Plasma Exchange; D011422:Propionates / Q000097:blood*; D006435:Renal Dialysis
D005663:Furans; D011422:Propionates; C041693:3-carboxy-4-methyl-5-propyl-2-furanpropionic acid; D003404:Creatinine