Use of a narcotic antagonist (nalmefene) to suppress self-mutilative behavior in a stallion.
Nalmefene, an opioid antagonist, caused a decrease in self-mutilative behavior in a 500-kg stallion. Self-mutilative attempts were counted during a control period and on 4 subsequent occasions after the IM administration of 100 mg, 200 mg, 400 mg, or 800 mg of nalmefene. The frequency of self-mutilation decreased with increasing doses of nalmefene and was virtually abolished with the 800-mg dose.
Dodman
N H
NH
Department of Surgery, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.
Shuster
L
L
Court
M H
MH
Patel
J
J
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D008297:Male; D009271:Naltrexone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D012652:Self Mutilation / Q000188:drug therapy / Q000662:veterinary*; D014743:Videotape Recording
D009292:Narcotic Antagonists; D009271:Naltrexone; C038981:nalmefene