Influence of age and consumption of tobacco, alcohol and caffeine on antipyrine clearance.
1. Antipyrine clearance and average daily consumption of tobacco, alcohol and coffee/tea were determined in 303 healthy men. 2. The antipyrine clearance was positively correlated with the consumption of tobacco (r = 0.24; P less than 0.0001) and coffee/tea (r = 0.18; P less than 0.001), and negatively with age (r = -0.14; P less than 0.05) and the alcohol consumption (r = -0.13; P less than 0.05). 3. The multiple regression coefficients suggested an increase in antipyrine clearance of 0.8% per daily cigarette or cup of tea and 1.4% per daily cup of coffee; the decrease per daily drink or year of age was 2.8% or 0.4%, respectively.
Loft
S
S
Department of Pharmacology, University of Copenhagen, Denmark.
Døssing
M
M
Poulsen
H E
HE
D000328:Adult; D000367:Age Factors; D000428:Alcohol Drinking; D000983:Antipyrine / Q000032:analysis / Q000493:pharmacokinetics*; D002110:Caffeine / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000032:analysis; D012907:Smoking
D002110:Caffeine; D000983:Antipyrine