[The selective elimination function of the colon in a rat model for the substances water and urea in long-term experiments as a contribution to the development of an implantable hemofilter-intestine-hybrid kidney].
The investigations on the selective elimination and preservation function of the colon represented one of the numerous problems in the development of an implantable hemofilter-intestine-hybrid kidney. The assumption of an ideal reflection of urea on the intestinal mucosa and the ability of water absorption of the colon had to be checked. A fluid which is nearly analogous to the ultrafiltrate with different urea concentrations was infused into the colon of rats by a cecocutaneous catheter fistula during two-phasic long-term experiments. The renal and enteral urea elimination rates were defined. The apparent reflection coefficient for urea of the colon amounted 0.5 to 0.6 in an infusion rate of 80 ml/day. The ability of water absorption of the colon in rats of nearly 300 g of weight could be increased up to 200 ml/day during slow and continuous adaptation in the infusion quantity.
Schröder
J
J
Abteilung Pathophysiologie, Wilhelm-Pieck-Universität Rostock.
Schumann
L
L
Wüstenberg
P W
PW
Dörp
E
E
Adam
U
U
Falkenhagen
D
D
Klinkmann
H
H
D000818:Animals; D001834:Body Water / Q000378:metabolism*; D003106:Colon / Q000502:physiology*; D004285:Dogs; D006440:Hemofiltration; D006801:Humans; D007688:Kidneys, Artificial; D008954:Models, Biological; D019736:Prostheses and Implants; D051381:Rats; D013997:Time Factors; D014508:Urea / Q000378:metabolism*
D014508:Urea
Untersuchungen zur selektiven Eliminationsfunktion des Kolons im Rattenmodell für die Substanzen Wasser und Harnstoff im Langzeitversuch als Beitrag zur Entwicklung einer implantierbaren Hämofilter-Darm-Hybridniere.