[Value of cyclosporin A in dermatomyositis in a child].
Cyclosporin A was used in a 3 1/2 year-old child with dermatomyositis exhibiting severe junctional impairment and intolerance to steroids. After a few weeks, marked clinical improvement was observed allowing a reduction of the doses of steroids. After 9 months, the clinical status was satisfactory: the calcifications had lost their inflammatory characteristics. No side effect of cyclosporin A was observed at the dose used (4.4 mg/kg/d) which maintained effective blood concentrations between 80 and 220 ng/ml.
Reinert
P
P
Service de Pédiatrie, Laboratoire Hospitalo-Universitaire de Pharmacologie, Centre Hospitalier Intercommunal, Créteil.
Hamberger
C
C
Rahimy
M C
MC
Dusseau
C
C
Bernaudin
F
F
Barre
J
J
Tillement
J P
JP
Lemerle
S
S
D002675:Child, Preschool; D003524:Cyclosporins / Q000627:therapeutic use*; D003882:Dermatomyositis / Q000188:drug therapy*; D004351:Drug Resistance; D005260:Female; D006801:Humans
D003524:Cyclosporins
Intérêt de la cyclosporine A dans la dermatomyosite de l'enfant.