Catalysis of a stereospecific bimolecular amide synthesis by an antibody.
We report a nonhydrolytic bimolecular aminolysis reaction catalyzed by an antibody. The stereospecific formation of an amide from racemic lactone plus an aromatic amine is described by a random equilibrium bireactant kinetic sequence. The observed turnover rate may be approximated from the measured difference between the binding of reactants and the transition state analog.
Benkovic
S J
SJ
Department of Chemistry, Pennsylvania State University, University Park 16802.
Napper
A D
AD
Lerner
R A
RA
D000577:Amides / Q000378:metabolism*; D000906:Antibodies; D002384:Catalysis; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D007783:Lactones / Q000378:metabolism; D010655:Phenylenediamines / Q000378:metabolism
D000577:Amides; D000906:Antibodies; D007783:Lactones; D010655:Phenylenediamines; C029728:4-phenylenediamine