[Hemodynamic action of isosorbide-5-mononitrate during rapid venous administration in patients with acute myocardial infarct].
20 patients with acute myocardial infarction were catheterized with a balloon thermodilution catheter and the hemodynamic changes following a rapid i.v. administration of 10 mg of isosorbide-5-mononitrate were studied up to the 4th hour. The drug causes a fall of the left ventricular filling pressure with 20%, of the arterial pressure with 5%, of the cardiac index with 9%, of the stroke index and of the stroke driving index and a slight increase of the systemic arterial vascular resistance without influencing the cardiac rate and the total pulmonary-vascular resistance. The drug action begins immediately, it is best expressed between the 3d and 30th minute and lasts 1-2 h. The hemodynamic changes are unidirectional in patients with left ventricular filling pressure below and above 1.9 kPa. The i.v. administration of isosorbide-5-mononitrate is indicated in the treatment of acute left cardiac failure in patients with acute myocardial infarction for the rapid reduction of pulmonary congestion and is suited for patients with a tendency toward arterial hypotension.
Daskalov
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T
D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization; D004341:Drug Evaluation; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate
Khemodinamichno deĭstvie na izosorbid-5-mononitrata pri bŭrzo venozno prilozhenie na bolni ot ostŭr miokarden infarkt.