Effects of rokitamycin on young rats with hyperbilirubinemia--determination of unbound and brain bilirubin levels and examination for localized yellow discoloration of brain tissue.
The effects of rokitamycin (RKM), a macrolide antibiotic, on young rats with hyperbilirubinemia were investigated. RKM at a dose of 1,000 mg/kg was orally administered to 14-day-old rats with hereditary, non-hemolytic hyperbilirubinemia (homozygous Gunn rats, total plasma bilirubin concentration: about 7 mg/dl). Animals given 10 ml/kg of 0.5% carboxymethyl cellulose (CMC) were used as control. Plasma total bilirubin concentration, plasma unbound bilirubin concentration and cerebellar bilirubin level did not significantly change during 1, 3, 6 and 24 hours after administration of RKM or CMC. There was no significant difference in plasma total bilirubin concentration, plasma unbound bilirubin concentration and cerebellar bilirubin level between RKM-treated and control animals at 1, 3, 6 and 24 hours after the administration. No localized yellow discoloration of the brain tissue (non-cerebellar parts) was noted at 1, 3, 6 and 24 hours after administration of either RKM or CMC.
Yamamura
H
H
Department of Anatomy, Mie University School of Medicine, Japan.
Ohsugi
M
M
Sakurai
S
S
Kobayashi
Y
Y
Sasaki
M
M
Yamamoto
H
H
D000818:Animals; D001663:Bilirubin / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002531:Cerebellum / Q000032:analysis / Q000378:metabolism; D006933:Hyperbilirubinemia, Hereditary / Q000378:metabolism*; D007647:Kernicterus / Q000473:pathology; D007933:Leucomycins / Q000008:administration & dosage / Q000494:pharmacology*; D015644:Miocamycin / Q000031:analogs & derivatives*; D051381:Rats; D011911:Rats, Gunn
D007933:Leucomycins; D015644:Miocamycin; D001663:Bilirubin; C033383:rokitamycin