title: Relationship between Mayer-Rokitansky-Küster (MRK) anomaly and hereditary renal adysplasia (HRA).
abstract: We report the results of a study performed in a sample of women with the Mayer-Rokitansky-Küster (MRK) anomaly and in their first-degree relatives. Our results are compatible with a traditional model of multifactorial determination; however, we cannot exclude the hypothesis of autosomal dominant inheritance, with an intermediate degree of penetrance and a highly variable expressivity of a single mutant gene. In this sense, our data seem to support the idea expressed recently by Opitz [1987].
authors.affiliation: Departamento de Biologia, Universidade de São Paulo, Brasil.
authors.forename: R de C
authors.initials: Rde C
authors.lastname: Pavanello
authors.forename: A
authors.initials: A
authors.lastname: Eigier
authors.forename: P A
authors.initials: PA
authors.lastname: Otto
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D005260:Female; D006801:Humans; D007668:Kidney / Q000002:abnormalities*; D010375:Pedigree