Experimental atherosclerosis in goats.
Varying degrees of aortic sudanophilia (5 to 75 per cent) comparable to human atherosclerotic lesions (fatty streaks/spots) developed in all nine experimental goats receiving 2 g of protected cholesterol daily for two, four and nine months. From the fifth month onward, the serum cholesterol level stabilised at 450 to 525 mg 100 ml-1. Aortic sudanophilia developed after two months but without any appreciable intimal thickening. Pronounced intimal thickening with foam cells was seen after four to nine months. The development of fatty streaks/spots was directly proportional to the degree of hypercholesterolaemia and duration of protected cholesterol feeding. It was concluded that goats could be useful in comparative atherosclerosis research.
Kaul
P L
PL
Division of Pathology, Indian Veterinary Research Institute, Uttar Pradesh.
Prasad
M C
MC
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D002784:Cholesterol / Q000097:blood; D006041:Goats / Q000097:blood*; D008055:Lipids / Q000097:blood
D008055:Lipids; D002784:Cholesterol