Prolonged intraperitoneal dwell decreases ultrafiltration coefficient in rabbits.
In rabbits undergoing peritoneal dialysis, hypertonic (6% dextrose) dialysis solution increased the net ultrafiltration rate (UF) from 233 to 462 microL/kg/min, which was not proportional to the increment in the osmotic gradient, so the ultrafiltration coefficient decreased. As intraperitoneal dwell of hypertonic dialysate was prolonged, the gross and net UFs and ultrafiltration coefficients decreased, and the UF per dextrose absorption declined. The decrement in UF was multifactorial, including a component of fluid and solute stagnation, increasing the distance over which osmotic forces must exert their effects. Excessively hypertonic dialysis fluid should be used only briefly to achieve ultrafiltration efficiently and to avoid the high dextrose loading.
Maher
J F
JF
Department of Medicine, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799.
Hirszel
P
P
Shostak
A
A
Di Paolo
B
B
Chakrabarti
E
E
D000042:Absorption; D000818:Animals; D005260:Female; D005947:Glucose / Q000493:pharmacokinetics*; D005950:Glucose Solution, Hypertonic / Q000493:pharmacokinetics*; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D011817:Rabbits; D013997:Time Factors; D014462:Ultrafiltration; D014882:Water-Electrolyte Balance
D005950:Glucose Solution, Hypertonic; D005947:Glucose