title: Selective and semiselective low-density lipoprotein apheresis in familial hypercholesterolemia.
abstract: Seven patients with familial hypercholesterolemia were treated fortnightly for 3 months by selective low-density lipoprotein apheresis with dextran-sulfate cellulose column (DSC). Subsequently, 4 of them were treated with semiselective double filtration. No cholesterol-lowering drugs were given. Plasma processed ranged from 39 to 58 ml/kg body weight/procedure. Fractional removals from plasma filtrate at the secondary treatment (adsorption or fractionation) for total cholesterol, high-density lipoprotein cholesterol, and albumin, respectively, were 0.84, 0.06, and 0.03 with DSC and 0.74, 0.47 and 0.35 with double filtration. Postapheresis reductions of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were 57, 15, and 59% with DSC and 47,35, and 48% with double filtration. Both methods are suitable for clinical use, but with a 15-day treatment schedule, lowering circulating lipid fraction levels are maintained with DSC.
authors.affiliation: Divisione di Nefrologia, Ospedale Cà Granda, Milano, Italia.
authors.forename: G
authors.initials: G
authors.lastname: Busnach
authors.forename: A
authors.initials: A
authors.lastname: Cappelleri
authors.forename: V
authors.initials: V
authors.lastname: Vaccarino
authors.forename: G
authors.initials: G
authors.lastname: Franceschini
authors.forename: A
authors.initials: A
authors.lastname: Dal Col
authors.forename: M L
authors.initials: ML
authors.lastname: Perrino
authors.forename: B
authors.initials: B
authors.lastname: Brando
authors.forename: C
authors.initials: C
authors.lastname: Sirtori
authors.forename: L
authors.initials: L
authors.lastname: Minetti
mesh_terms: D000293:Adolescent; D000328:Adult; D001059:Apoproteins / Q000097:blood; D001781:Blood Component Removal / Q000379:methods*; D002648:Child; D002784:Cholesterol / Q000097:blood; D005260:Female; D006440:Hemofiltration; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D001059:Apoproteins; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D002784:Cholesterol