The selenium status of children with phenylketonuria: results of selenium supplementation.
The selenium status of children with phenylketonuria on a synthetic low phenylalanine diet was assessed. Correlation between blood selenium and red cell glutathione peroxidase was unsatisfactory (r = 0.65) due to the poor discrimination of red cell glutathione peroxidase with a low selenium diet. No symptoms of deficiency were observed. Supplementation with 50 micrograms per week of selenium as brewers yeast tablets over a period of 6 months significantly increased the blood selenium of the phenylketonuric children. Plasma Vitamin E levels were within normal limits. The supplementation effectively doubled their selenium intake to 15-17 micrograms per day, which is probably sufficient for this group with an adequate Vitamin E status, though considerably lower than the recommended minimum intake of 50 micrograms per day.
Lipson
A
A
Metabolic Clinic, Children's Hospital, Camperdown, New South Wales, Australia.
Masters
H
H
O'Halloran
M
M
Thompson
S
S
Coveney
J
J
Yu
J
J
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007223:Infant; D010661:Phenylketonurias / Q000097:blood* / Q000178:diet therapy; D012643:Selenium / Q000008:administration & dosage* / Q000097:blood / Q000172:deficiency
D005979:Glutathione Peroxidase; D012643:Selenium