Negative ion mass spectra of dihydropyridine calcium-channel blockers.
The negative ion mass spectra of some dihydropyridine analogues of nifedipine are studied; they show a fragmentation which is highly dependent on the position of the nitro group on the phenyl ring: 3'-nitro derivatives give essentially the molecular anion, whereas 2'-nitro derivatives lose successively H2O, RO and O. In addition, (2,1,3-benzoxadiazol-4-yl) derivatives show essentially a [M-ROH]- peak. Possible pathways for these fragmentations are given.
Ehrhardt
J D
JD
Spectrométrie de Masse, Institut de Pharmacologie (UA 589 CNRS), Faculté de Médecine 11, Strasbourg, France.
Ziegler
J M
JM
D002121:Calcium Channel Blockers / Q000032:analysis*; D004095:Dihydropyridines / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D013058:Mass Spectrometry; D010084:Oxidation-Reduction
D002121:Calcium Channel Blockers; D004095:Dihydropyridines