title: Effect of glucocorticoid hormones on the growth of human fibroblast cells and interferon production.
abstract: Human diploid fibroblasts could be passaged serially on microcarriers and used as an efficient system for the bulk production of human interferon-beta (IFN-beta), provided that appropriate amounts of glucocorticoid hormones were added to the fetal bovine serum used in the medium; alternatively, precolostrum newborn calf serum, which has a relatively high content of hydrocortisone, could be used.
authors.affiliation: Basic Research Laboratories, Toray Industries Inc., Kamakura, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Sano
authors.forename: M
authors.initials: M
authors.lastname: Iizuka
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003470:Culture Media; D004171:Diploidy; D005347:Fibroblasts / Q000166:cytology*; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis*
chemical_list: D003470:Culture Media; D005938:Glucocorticoids; D007370:Interferon Type I