title: [Mixed connective tissue disease (Sharp's syndrome)--a case report].
abstract: A case of a 45-year-old woman with a prolonged disease (more than 16 years) is reported. The initial manifestations were those of Raynaud's syndrome. Later a very complex combination of symptoms and syndromes developed which included: arthritis, arthralgia, skin eruptions, lymphadenopathy, hepatosplenomegaly, a tendency toward sclerodermic changes of the face and the distal parts of the fingers, Sjogren's syndrome, slight anemia, transient leucopenia, fast ESR, increased serum immunoglobulin G and A levels and presence of high antibody titres against a nuclear ribonucleoprotein. The authors consider the case as a mixed connective tissue disease.
authors.forename: Z
authors.initials: Z
authors.lastname: Gatsev
authors.forename: S
authors.initials: S
authors.lastname: Vŭlev
mesh_terms: D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000175:diagnosis / Q000473:pathology*
vernacular_title: Smesena sŭedinitelnotŭkanna bolest (sindrom na Sharp)--opisanie na edin sluchaĭ.