title: Influence of dialysate and membrane biocompatibility on hemodynamic stability in hemodialysis.
abstract: The contributions of membrane biocompatibility, dialysate temperature and sodium concentration to hemodynamic stability during hemodialysis were studied in 8 patients with a high incidence of hemodialysis-induced symptomatic hypotension. Patients were treated during 8 different periods, randomly ordered in each case, resulting from the combination of the following: the membrane, either Cuprophan or Polyacrylonitrile; the dialysate temperature, 37 or 35 degrees C, and the sodium concentration, 133 or 139 mmol/l. The incidence of symptomatic hypotension was lower at 35 degrees C in the entire study with either membrane and either sodium concentration. It was also lower with a sodium concentration of 139 mmol/l with either temperature and either membrane. There was a lower incidence of symptomatic hypotension when using Polyacrylonitrile, but this difference was not significant. We conclude that changes in physicochemical parameters of dialysate lead to worth-while improvement of symptomatic hypotension in hemodialysis patients, but membrane biocompatibility seems to play a minor role.
authors.affiliation: Servicio de Nefrologia, Hospital Ramon y Cajal Madrid-Spain.
authors.forename: C
authors.initials: C
authors.lastname: Quereda
authors.forename: L
authors.initials: L
authors.lastname: Orofino
authors.forename: R
authors.initials: R
authors.lastname: Marcen
authors.forename: J
authors.initials: J
authors.lastname: Sabater
authors.forename: R
authors.initials: R
authors.lastname: Matesanz
authors.forename: J
authors.initials: J
authors.lastname: Ortuño
mesh_terms: D000368:Aged; D001672:Biocompatible Materials; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D006435:Renal Dialysis / Q000295:instrumentation / Q000379:methods*; D012964:Sodium; D012996:Solutions; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; D012996:Solutions; D012964:Sodium