title: Molecular and cytogenetic evidence for the location of Tdy and Hya on the mouse Y chromosome short arm.
abstract: Using a combination of in situ mapping and DNA analysis with recombinant DNA probes specific for the Sxr region of the mouse Y chromosome, we show that both the gene(s) controlling sex determination and the expression of the male-specific antigen H-Y (Tdy and Hya, respectively) are located on the minute short arm of the mouse Y chromosome. We demonstrate that the H-Y- variant of Sxr (Sxr') arose by a partial deletion within the Sxr region. Also, we show that intrachromosomal recombination between the Y short arm and Sxr' can sometimes occur during male meiosis, restoring the deleted DNA sequences and resulting in an H-Y+ mouse (male 719 in this paper). Based on these results, we propose a model for the generation of the original Sxr region and the Sxr' and Sxr719 variants.
authors.affiliation: Unité d'Immunogénétique Humaine, Institut National de la Santé, Institut Pasteur, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Roberts
authors.forename: A
authors.initials: A
authors.lastname: Weith
authors.forename: E
authors.initials: E
authors.lastname: Passage
authors.forename: J L
authors.initials: JL
authors.lastname: Michot
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: C E
authors.initials: CE
authors.lastname: Bishop
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004274:DNA, Recombinant / Q000378:metabolism; D008099:Liver / Q000502:physiology; D008297:Male; D051379:Mice / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D012732:Sex Determination Analysis; D014998:Y Chromosome
chemical_list: D004274:DNA, Recombinant; D004247:DNA