Effects of cholecystokinin-related peptides on self-stimulation behaviour in rats.
The effects of cholecystokinin octapeptide sulfate ester (CCK-8-SE), its N-terminal tripeptide (CCK-2-4-SE) and its C-terminal tetrapeptide (CCK-5-8) were investigated on hypothalamic self-stimulation in rats. CCK-8-SE and CCK-5-8 in 400 pmole doses inhibited self-stimulation behaviour, while CCK-2-4-SE was ineffective. In 80 pmole doses the peptides showed no effect. It is suggested that CCK-5-8 itself influences self-stimulation behaviour.
Balázs
M
M
Department of Pathophysiology, University Medical School, Szeged, Hungary.
Schwarzberg
H
H
Penke
B
B
Telegdy
G
G
D000818:Animals; D002766:Cholecystokinin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004558:Electric Stimulation; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012653:Self Stimulation / Q000187:drug effects*; D013329:Structure-Activity Relationship
D002766:Cholecystokinin