Reduced fertility in gracile axonal dystrophy (gad) mice.
Mean litter size in gad/gad females was significantly lower than in normal females (+/+ and gad/+) in intra- and inter-strain crosses. The reduction in litter size was not dependent on the genotypes of the males, but could be attributed to the gad/gad females themselves. The numbers of corpora lutea and implants in gad/gad females were slightly reduced as compared with those in the controls, but the number of live fetuses was significantly lower than that in normal females 14 days after copulation (P less than 0.02). Hence, reduced litter size in gad/gad females was accounted for mostly by embryonic and fetal death after implantation, which was inferred to be due to impaired uterine function.
Yamazaki
K
K
Laboratory of Animal Genetics, Faculty of Agriculture, Nagoya University, Japan.
Wakasugi
N
N
Sakakibara
A
A
Tomita
T
T
D000818:Animals; D001369:Axons / Q000473:pathology; D003338:Corpus Luteum; D010064:Embryo Implantation; D005260:Female; D005298:Fertility; D005313:Fetal Death; D008098:Litter Size; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000235:genetics*; D009410:Nerve Degeneration; D009422:Nervous System Diseases / Q000235:genetics*; D011247:Pregnancy; D013116:Spinal Cord / Q000473:pathology; D014599:Uterus / Q000503:physiopathology