Ventricular septal defect with overriding aorta in trisomy-18.
In a child with trisomy-18 prenatal echocardiography demonstrated the presence of a ventricular septal defect with overriding aorta. In a previous anatomical study of 18 hearts with this malformation we found a 50% concurrence rate with trisomy-18. In case of prenatal echocardiographic detection of a ventricular septal defect with overriding aorta, we advise thorough ultrasound examination for additional malformations as seen in trisomy-18; subsequently this procedure should be completed by cytogenetic analysis of amniotic cells.
Moene
R J
RJ
Department of Paediatric Cardiology, Free University Hospital, Amsterdam, The Netherlands.
Sobotka-Plojhar
M
M
Oppenheimer-Dekker
A
A
Lindhout
D
D
D001011:Aorta / Q000002:abnormalities*; D002887:Chromosomes, Human, Pair 18; D004452:Echocardiography; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D011296:Prenatal Diagnosis; D014314:Trisomy