A method for determining the primary effect of a stimulus in tonically firing neurons using spike train analysis.
We present a novel method for measuring changes in the timing of spikes evoked by a stimulus in single neurons. The result provides an unambiguous separation of the stimulus effect from effects due to intrinsic spike train patterns. This separation facilitates the comparison of responses in different neurons. The analysis is based only on the spike train and requires no models of the underlying cell behavior.
Osborn
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Laboratory of Neurophysiology, University of Minnesota, Minneapolis 55455.
Poppele
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D000200:Action Potentials; D003198:Computer Simulation; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D009482:Neurophysiology / Q000379:methods*