Immediate effect of irradiation on microvasculature.
The immediate effects of irradiation on microvasculature in muscle in an animal model are described in this paper. By using triple isotopes of 125I, 131I, and 22Na, the transcapillary transfer of albumin from the vascular bed to the extravascular space is determined in terms of mg/g of tissue, after single doses of 2 to 14 Gy. These results reveal an increase in the extravascular albumin immediately after irradiation and suggest an instantaneous compromise in vascular permeability even after 2 Gy. This effect was apparently dose related.
Krishnan
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Department of Radiation Oncology, University of Kansas College of Health Sciences and Hospital, Kansas City 66103.
Krishnan
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EC
Jewell
W R
WR
D000818:Animals; D002199:Capillary Permeability / Q000528:radiation effects*; D008833:Microcirculation / Q000528:radiation effects; D009132:Muscles / Q000098:blood supply*; D011817:Rabbits; D012711:Serum Albumin, Radio-Iodinated; D012979:Sodium Radioisotopes
D012711:Serum Albumin, Radio-Iodinated; D012979:Sodium Radioisotopes