title: Suppression of sleep by prostaglandin synthesis inhibitors in unrestrained rats.
abstract: Sleep-suppressive activity of prostaglandin synthesis inhibitors, diclofenac sodium (DF) and indomethacin (IM), was examined in unrestrained male rats. An intraperitoneal injection of 5 mg/kg IM, or an oral administration of 5 mg/kg DF and 10 mg/kg IM at an early phase of the light period transiently decreased slow wave sleep (SWS) and paradoxical sleep (PS) to 30-62% and 0-38%, respectively, of the control level in the first hour. An intravenous infusion of 0.4 mg DF or 0.4 mg IM or an intracerebroventricular infusion of 0.04 mg DF continuously during a 10-h diurnal period resulted in a significant decrease in SWS and PS by 9-17% and 17-21%, respectively, from the baseline value in the 12-h light period. The DF infusion was accompanied by a rebound rise in the nocturnal SWS and PS and the subsequent diurnal PS. The results indicate that the depletion of prostaglandin(s) in the brain is responsible for the DF- and IM-induced suppression of sleep.
authors.affiliation: Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Naito
authors.forename: H
authors.initials: H
authors.lastname: Osama
authors.forename: R
authors.initials: R
authors.lastname: Ueno
authors.forename: O
authors.initials: O
authors.lastname: Hayaishi
authors.forename: K
authors.initials: K
authors.lastname: Honda
authors.forename: S
authors.initials: S
authors.lastname: Inoué
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004008:Diclofenac / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D007213:Indomethacin / Q000008:administration & dosage*; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects*
chemical_list: D011453:Prostaglandins; D004008:Diclofenac; D007213:Indomethacin