title: [Preventive use of antibacterials with a single administration of 1 g ceftriaxone in gynecology and obstetrics].
abstract: An indication for prophylaxis in vaginal and abdominal hysterectomy is given in the case of high postoperative infection morbidity. In order to reach an adequate level of antibacterial activity in serum and tissue one should apply the initial dose before the operation. The presence of various risk factors in Caesarean section is also an indication for prophylaxis. This applies especially to emergency Caesarean sections which have an increased infection rate. The application of the substance should follow the separation of the child from the mother after cutting the umbilical cord in order to prevent a diaplacental diffusion of the substance which can lead to a false diagnosis of the newborn. Our clinical studies demonstrated that an infection prophylaxis in gynaecological obstetrical standard operations is very effective with a single application of 1 g Ceftriaxone. Only 1 from 90 patients developed a postoperative infection. There were only 2 patients with side effects, which were diarrhoea and an allergical reaction. The hematological, hepatical and nephrological function tests did not indicate any alteration of values related to the test substance. Finally we have observed that Ceftriaxone has not only proven to be highly effective in a perioperative antibiotic prophylaxis in extensive gynaccological and obstertrical operations, but also a compatible medicament in view of the rare occurrence of side effects. The clinical application of this medicament in gynaecology and obstetrics can therefore be recommended.
authors.affiliation: Frauenklinik des St. Marienkrankenhauses, Frankfurt/Main.
authors.forename: Z
authors.initials: Z
authors.lastname: Hrgovic
authors.forename: H
authors.initials: H
authors.lastname: Böckler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002443:Ceftriaxone / Q000008:administration & dosage*; D002585:Cesarean Section; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007045:Hysterectomy, Vaginal; D008875:Middle Aged; D011247:Pregnancy; D011292:Premedication; D012086:Reoperation; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D002443:Ceftriaxone
vernacular_title: Antibakterielle Prophylaxe mit einer einmaligen Gabe von 1 g Ceftriaxon in der Gynäkologie und Geburtshilfe.