title: A twin study of amino acid concentrations in cerebrospinal fluid.
abstract: The concentrations of amino acids in the cerebrospinal fluid (CSF) were measured in pairs of healthy mono- and dizygotic twins. Intraclass correlations were calculated. Genetic and cultural heritabilities were estimated using a path analytical model. CSF levels of glycine, tyrosine and arginine were shown to be influenced by genetic factors. Genetic variation was also shown for serine, alpha-aminobutyrate and leucine. The results were compared with results from a genetic analysis of the amino acids in serum.
authors.affiliation: Department of Clinical Chemistry, Karolinska Institute, Stockholm, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Hagenfeldt
authors.forename: G
authors.initials: G
authors.lastname: Oxenstierna
authors.forename: G
authors.initials: G
authors.lastname: Alfredsson
authors.forename: G
authors.initials: G
authors.lastname: Edman
authors.forename: L
authors.initials: L
authors.lastname: Iselius
authors.forename: G
authors.initials: G
authors.lastname: Sedvall
mesh_terms: D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014427:Twins; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
chemical_list: D000596:Amino Acids