title: Automatic ventricular edge detection for determination of left ventricular volumes, ejection fraction and regional ejection fractions from first pass radioisotope angiography.
abstract: An automated method for detection of left ventricular (LV) outline (including the aortic and mitral valve planes) was developed for measurements of end-diastolic volume (EDV), end-systolic volume (ESV), global ejection fraction (EF), and regional EFs from first pass radioisotope ventriculography. The procedure includes: (1) interpolative background subtraction, (2) construction of gradient images, (3) automatic detection of valve planes, and (4) automatic radial search of LV outlines. The correlation between contrast angiography and Tc-99m first pass study was r = 0.84 (SEE = 23.4) for EDV, r = 0.93 (SEE = 12.8) for ESV, r = 0.84 (SEE = 6.91) for EF (via counts) and r = 0.80 (SEE = 8.56) for EF (via area-length method). Tests of intra-observer, inter-observer and inter-study variability revealed low level of variability. The results showed the potential of the automation of data processing for first pass radioisotope ventriculography.
authors.affiliation: Department of Nuclear Medicine, Changhua Christian Hospital, Taiwan, R.O.C.
authors.forename: K T
authors.initials: KT
authors.lastname: Yang
authors.forename: C J
authors.initials: CJ
authors.lastname: Thompson
authors.forename: I
authors.initials: I
authors.lastname: Mena
mesh_terms: D002306:Cardiac Volume; D006321:Heart / Q000000981:diagnostic imaging*; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D011859:Radiography; D011875:Radionuclide Angiography; D013318:Stroke Volume