Pharmacokinetics of pralidoxime chloride and its correlation to therapeutic efficacy against diisopropyl fluorophosphate intoxication in rats.
A two compartment system is used to study the therapeutic efficacy of pralidoxime chloride (1) along with a suitable pretreatment against diisopropyl fluorophosphate (2) intoxication in rats. The data were analyzed by standard techniques. Though thiamine hydrochloride pretreatment prolonged the biological half-life of 1 but it failed to increase the protective efficacy of 1, on the other hand sodium hydrogen carbonate pretreatment augmented the protective action of 1 without altering its biological half-life appreciably, through increased distribution of 1 into tissue compartment.
Jeevarathinam
K
K
Defence Research and Development Establishment, Gwalior, India.
Ghosh
A K
AK
Srinivasan
A
A
Das Gupta
S
S
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D006207:Half-Life; D007531:Isoflurophate / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D011220:Pralidoxime Compounds / Q000493:pharmacokinetics* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D011220:Pralidoxime Compounds; D007531:Isoflurophate; D001285:Atropine