title: [Effect of intratracheal administration of gentamycin in exacerbations of suppurative bronchitis due to gram-negative bacteria and Staphylococcus].
abstract: The effect of intratracheal administration of gentamicin (G) was observed in 22 patients in exacerbations of chronic purulent bronchitis caused by gram-negative bacteria and staphylococcus. A high concentration of gentamicin quickly occurred in the sputum, it always exceeded a minimum concentration suppressing the growth of an agent isolated from the sputum but its absorption from the respiratory tracts was poor: in half of the patients it hardly penetrated the blood, in the rest of them its concentration in the blood was insignificant. In order to potentiate the therapeutic effect in some of the patients, penicillin or gentamicin administration should be continued intramuscularly. The duration and type of antibacterial therapy must be based on the results of bacteriological investigation of the sputum in the course of treatment.
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Shteĭngardt
authors.forename: E L
authors.initials: EL
authors.lastname: Mishustina
authors.forename: E V
authors.initials: EV
authors.lastname: Nemerov
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D001991:Bronchitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D004341:Drug Evaluation; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006090:Gram-Negative Bacteria; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013183:Sputum / Q000032:analysis / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013997:Time Factors; D014132:Trachea
chemical_list: D005839:Gentamicins
vernacular_title: Effekt vnutritrakheal'nogo vvedeniia gentamitsina pri obostreniiakh gnoĭnogo bronkhita, vyzvannykh gramotritsatel'nymi bakteriiami i stafilokokkom.