title: Pharmacokinetics of oxytetracycline in clinical cases in the red-necked wallaby (Macropus rufogriseus).
abstract: Oxytetracycline, administered at 40 mg kg-1 by intravenous injection, was used as part of the treatment of three female red-necked wallabies, Macropus rufogriseus, with suspected Fusobacterium necrophorum infections. The plasma concentrations of this drug in blood samples collected at intervals up to 24 hours after administration were measured using a biological assay. The pattern of decline in plasma oxytetracycline concentration with time was consistent with a two-compartment model. The half-life of the elimination phase was calculated to be 11.4 hours and the apparent volume of distribution was found to be 2.041 litres kg-1. These results provide a basis for devising appropriate oxytetracycline dosage regimes for the species.
authors.affiliation: Institute of Zoology, Zoological Society of London, London.
authors.forename: J K
authors.initials: JK
authors.lastname: Kirkwood
authors.forename: F M
authors.initials: FM
authors.lastname: Gulland
authors.forename: J R
authors.initials: JR
authors.lastname: Needham
authors.forename: M G
authors.initials: MG
authors.lastname: Vogler
mesh_terms: D000818:Animals; D005260:Female; D005674:Fusobacterium Infections / Q000188:drug therapy / Q000662:veterinary*; D005675:Fusobacterium necrophorum; D007614:Macropodidae / Q000382:microbiology*; D008394:Marsupialia / Q000382:microbiology*; D010118:Oxytetracycline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D010118:Oxytetracycline