title: Rapidly progressive osteoarthrosis of ochronotic origin. A pathologic study.
abstract: A case of hip osteoarthrosis associated with ochronosis in a 65-year-old woman is reported. Characteristic features of both conditions were observed macroscopically and on light and electron microscopic examination. In the cartilage the pigment deposits were located on and between thick collagen fibrils. In the synovial membrane there were embedded packets of cartilage shards of which the collagen fibrils and pigment were phagocytosed, as well as calcified bone debris whose disaggregation might have explained the presence of some apatite deposits free of any underlying collagen structure. As also previously observed, the present case of ochronotic hip osteoarthrosis is remarkable for the minor osteophyte formation and for the inclusion of pigmented cartilage shards in the osteomedullar remodeled territory. It also demonstrates a collapse of the femoral head cortex presumably related to the rapid clinical and radiologic evolution. By the well-known origin of its chondropathy and by the pigment labeling of the cartilage, ochronotic arthropathy provides an almost experimental model for analyzing a broader problem, i.e., that of the various components of an osteoarthrotic remodeling.
authors.affiliation: Department of Pathology (Osteoarticular Unit), University of Geneva Medical School, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Lagier
authors.forename: C A
authors.initials: CA
authors.lastname: Baud
authors.forename: D
authors.initials: D
authors.lastname: Lacotte
authors.forename: T
authors.initials: T
authors.lastname: Cunningham
mesh_terms: D000368:Aged; D001847:Bone Diseases / Q000209:etiology* / Q000473:pathology; D002358:Cartilage, Articular / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000209:etiology* / Q000473:pathology; D008854:Microscopy, Electron; D009794:Ochronosis / Q000150:complications* / Q000378:metabolism; D013583:Synovial Membrane / Q000648:ultrastructure