title: The effect of etomoxir on glucose turnover and recycling with [1-14C], [3-3H]-glucose tracer in pigs.
abstract: Infusion of etomoxir to 4 fasted pigs caused significant (48%) falls in blood glucose concentrations. To assess whether inhibition of hepatic glucose production or increase of peripheral glucose utilisation is causally associated, a primed infusion of [3-3H]-glucose and [1-14C]-glucose was used, and glucose turnover rates, recycling and metabolic clearance rate of glucose were determined. No effects of infusion of etomoxir on glucose turnover rates could be found. Recycling of glucose carbon was affected to a relatively small extent. The metabolic clearance rate, however, increased by 126% from 5.0 +/- 0.7 ml/kg x min in the control group to 11.3 +/- 3.5 ml/kg x min in the treated group (mean +/- SEM; P less than 0.05). We conclude that under fasting conditions an increase in glucose utilization plays a major part in the blood glucose lowering effect of etomoxir.
authors.affiliation: Abteilung für Biochemie, Byk Gulden Lomberg, Chemische Fabrik GmbH, Konstanz, Germany.
authors.forename: H P
authors.initials: HP
authors.lastname: Wolf
authors.forename: K V
authors.initials: KV
authors.lastname: Brenner
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004852:Epoxy Compounds / Q000494:pharmacology*; D004988:Ethers, Cyclic / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D013552:Swine
chemical_list: D001786:Blood Glucose; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D007004:Hypoglycemic Agents; D005947:Glucose; C054207:etomoxir