A patient with methotrexate lung and granulomatous changes in the liver--or just sarcoidosis?
A 57 year old ex-miner, who had been treated for his psoriasis with methotrexate 5 mg 3 times a week, taken orally (in total +/- 12 g) developed in the spring 1985 the symptoms of an allergic pneumonia. In biopsies of lung and liver non-caseating granulomata were found, compatible with the diagnosis sarcoidosis. The question whether one clinical entity is concerned or two superponed diseases, remains unanswered.
van Deursen
C T
CT
Department of Respiratory Diseases, De Weverhospital, Heerlen, The Netherlands.
Koudstaal
J
J
Maesen
F P
FP
D001784:Blood Gas Analysis; D001831:Body Temperature; D056486:Chemical and Drug Induced Liver Injury; D003937:Diagnosis, Differential; D006099:Granuloma / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D011859:Radiography; D012129:Respiratory Function Tests; D012507:Sarcoidosis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology
D008727:Methotrexate