Once daily Theo-Dur in morning dippers.
In a group of 18 patients with a so-called "morning dip", one single dose of theophylline was administered at 10:00 p.m. by means of a sustained release formulation (Theodur Retard). The dosage of theophylline was adjusted according to the complaints of the patients. Plasma theophylline levels were determined at 10:00 a.m. to prevent theophylline intoxications. The results were objectivated by measuring the PEFR twice/day. When the optimal dosage was obtained, a once/day administration of Theodur Retard at 10:00 p.m. provided an improved peak flow in the early morning, less symptoms at night and a better quality of sleep.
van der Vet
A P
AP
Department of Pulmonology, University Hospital Maastricht, The Netherlands.
Quaedvlieg
M
M
Greve
L H
LH
D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D012893:Sleep Wake Disorders / Q000139:chemically induced; D013806:Theophylline / Q000008:administration & dosage* / Q000009:adverse effects
D003692:Delayed-Action Preparations; D013806:Theophylline