[A case of advanced breast cancer successfully treated with combined tamoxifen and epitiostanol].
A patient with stage IV advanced breast cancer with multiple metastasis (bones of the whole body, lungs) were treated by ovariectomy, administration of an non-steroidal antiestrogen (tamoxifen) and mild chemotherapeutic drugs, with favorable results. After four years, however, the patient had a relapse of the cancer. A steroidal antiestrogen (epitiostanol) was then administered with satisfactory results. When a breast cancer relapse occurs in patients once treated successfully with endocrinotherapy, a different form of endocrinotherapy should be tried. There is a possibility that the mechanism of action of Epitiostanol, which is regarded as a steroidal antiestrogen, is different from that of tamoxifen in which an estrogen receptor (ER) system is included.
Konishi
Y
Y
2nd Dept. of Surgery, School of Medicine, University of Tokushima.
Morimoto
T
T
Komaki
K
K
Yamakawa
T
T
Mituyama
N
N
Tanaka
T
T
Oomine
Y
Y
Monden
Y
Y
D000732:Androstanols / Q000008:administration & dosage* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D004965:Estrogen Antagonists / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D010052:Ovariectomy; D013629:Tamoxifen / Q000008:administration & dosage* / Q000627:therapeutic use
D000732:Androstanols; D004965:Estrogen Antagonists; D013629:Tamoxifen; C002976:epitiostanol