title: Distribution of SC-4453, a new semi-synthetic derivative of digoxin, following an infusion preceded by an i.v. loading dose in the guinea-pig. Binding to plasma proteins.
abstract: The tissue distribution of 12 alpha-[3H]SC-4453 was studied in the guinea-pig after a 15 hours infusion at the rate of 4 micrograms/h/kg, preceded by an IV loading dose. At the end of the infusion, at the steady state, the skeletal muscle apparently presented the highest concentration of SC-4453 (24 ng/g) and the brain the lowest (1.2 ng/g), which demonstrates the presence of a blood-brain barrier to this compound. Our results also show that this new semi-synthetic cardiotonic presents a weak affinity to plasma proteins (25%).
authors.affiliation: Laboratoire de Pharmacologie, EES Sciences, Antananarivo, Madagascar.
authors.forename: F
authors.initials: F
authors.lastname: Randimbivololona
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002301:Cardiac Glycosides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004077:Digoxin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D006168:Guinea Pigs; D007275:Injections, Intravenous; D011485:Protein Binding; D014018:Tissue Distribution
chemical_list: D001798:Blood Proteins; D002301:Cardiac Glycosides; C020963:SC 4453; D004077:Digoxin