title: Specific motor effects of capsaicin on human jejunum.
abstract: Capsaicin (1 microM) produced a biphasic effect on the motility of longitudinal muscle strips from human jejunum e.g. an initial inhibitory effect on nerve-mediated contractions followed by a delayed increase in motility. Neither effect was observed upon a second application of the drug, indicating desensitization, a proposed marker of the action of capsaicin on sensory nerves. Both substance P and neurokinin A produced a contraction of isolated human jejunum, while calcitonin gene-related peptide had a small and inconsistent inhibitory effect.
authors.affiliation: Pharmacology Department, Menarini Pharmaceuticals, Florence, Italy.
authors.forename: C A
authors.initials: CA
authors.lastname: Maggi
authors.forename: R
authors.initials: R
authors.lastname: Patacchini
authors.forename: P
authors.initials: P
authors.lastname: Santicioli
authors.forename: S
authors.initials: S
authors.lastname: Giuliani
authors.forename: D
authors.initials: D
authors.lastname: Turini
authors.forename: G
authors.initials: G
authors.lastname: Barbanti
authors.forename: P
authors.initials: P
authors.lastname: Beneforti
authors.forename: D
authors.initials: D
authors.lastname: Misuri
authors.forename: A
authors.initials: A
authors.lastname: Meli
mesh_terms: D000328:Adult; D000368:Aged; D002211:Capsaicin / Q000494:pharmacology*; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007583:Jejunum / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*
chemical_list: D002211:Capsaicin