title: Potentiating the effectiveness of influenza vaccination by a combined immunostimulation with P40 immunomodulator: an experimental study in mice.
abstract: Influenza vaccination is highly desirable in view of the epidemic character of this infection and of the severity that it can assume in high-risk and in elderly persons. Its effectiveness varies from 40-90%. Moreover, strains can undergo an antigenic drift in the course of an epidemic. Consequently, reinforcement of the immunogenicity of vaccines is required for achieving a more complete immunization coverage. Combination of an immunomodulator, the C. granulosum-derived P40 fraction, with influenza vaccine resulted in significant potentiation of vaccine immunogenicity. In addition to its adjuvant action, the P40 is also likely to exercise a protective effect by stimulating the non-specific immune defenses of the organism.
authors.affiliation: Université de Paris-Sud, Laboratoire de Microbiologie, Faculté de Pharmacie, Châtenay-Malabry, France.
authors.forename: M
authors.initials: M
authors.lastname: Fattal-German
authors.forename: A
authors.initials: A
authors.lastname: German
authors.forename: B
authors.initials: B
authors.lastname: Bizzini
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D003352:Corynebacterium / Q000276:immunology; D005260:Female; D007252:Influenza Vaccines / Q000276:immunology*; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000517:prevention & control*; D014611:Vaccination
chemical_list: D000276:Adjuvants, Immunologic; D007252:Influenza Vaccines