title: [Clinical studies on various therapy for the intractable trauma of toes and fingers in cases of diabetes mellitus and peripheral ischemic diseases].
abstract: In cases of ischemic extremities and diabetes mellitus, the trauma on finger and toe is very intractable. For such injuries amputation of extremity is indicated very often because of severe necrosis. The number of such cases has been increasing recently because many cases of these patients have arteriosclerotic arterial occlusion and diabetes mellitus, and these are correlated with the changes of aging. The number of cases of Buerger's disease has been also increasing and it is another etiology of intractable trauma in ischemic extremity. The repeated hyperbaric oxygenation, sympathetic block, warfarin therapy and insulin bath with bubbling of hyperbaric oxygen, were applied to has been of such necrosis. By these procedures, the rate of amputation of extremity decreasing. It was concluded that the surgical reconstruction of artery for ischemic extremity has never any meaning as the therapy of such intractable injuries, if blood flow in the peripheral tissue is not kept physiologically, before vascular reconstruction. In order to increase peripheral tissue circulation, the hyperbaric oxygenation, sympathetic block and warfarin therapy wer performed in many cases and these methods were very effective for intractable injuries with severe necrosis.
authors.affiliation: Second Department of Surgery, School of Medicine, Kinki University, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kuyama
authors.forename: H
authors.initials: H
authors.lastname: Umemura
authors.forename: T
authors.initials: T
authors.lastname: Sudo
authors.forename: M
authors.initials: M
authors.lastname: Kawamura
authors.forename: R
authors.initials: R
authors.lastname: Shobu
authors.forename: R
authors.initials: R
authors.lastname: Tsubakimoto
authors.forename: A
authors.initials: A
authors.lastname: Nishimoro
mesh_terms: D000328:Adult; D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000150:complications; D003925:Diabetic Angiopathies / Q000150:complications*; D005260:Female; D005383:Finger Injuries / Q000628:therapy*; D006801:Humans; D006931:Hyperbaric Oxygenation; D007511:Ischemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000628:therapy; D011928:Raynaud Disease / Q000150:complications; D013919:Thromboangiitis Obliterans / Q000150:complications; D014034:Toes / Q000098:blood supply / Q000293:injuries*; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D014859:Warfarin