The relationship between route of infection and minimum infectious dose: studies with lactate dehydrogenase-elevating virus.
At present there is incomplete knowledge concerning the relationship of route of infection to minimum infectious dose (MID) for viruses of humans or other animals. The present work has used lactate dehydrogenase-elevating virus (LDV) as a mouse model for this relationship. The data establish a relative mucosal barrier to LDV transmission, which is more effective at oral, ocular and vaginal sites, than at the rectal site of inoculation.
Cafruny
W A
WA
Department of Microbiology, School of Medicine, University of South Dakota, Vermillion 57069.
Hovinen
D E
DE
D000818:Animals; D005260:Female; D007772:Lactate dehydrogenase-elevating virus / Q000472:pathogenicity*; D051379:Mice; D009092:Mucous Membrane / Q000382:microbiology; D014777:Virus Diseases / Q000635:transmission*