Inhibition of benzoyl peroxide/Cu2+-dependent lipid peroxidation by manganese.
1. Formation of peroxides by benxoyl peroxide (BPO) and CuCl2 was examined in the human red blood cell ghost. 2. Amounts of peroxides formed increased with the amount of the ghost solution added. 3. Of all the cations tested only manganese ion inhibited the formation of peroxides in BPO-CuCl2 reaction system. 4. The formation of peroxides was inhibited approx. 50% with 0.4 microM manganese. 5. The inhibitory manner of manganese was non-competitive against copper.
Tsujimoto
Y
Y
Department of Endodontics, Nihon University School of Dentistry, Matsudo, Chiba, Japan.
Nagashima
K
K
Yamazaki
M
M
Furuyama
S
S
D001585:Benzoyl Peroxide / Q000494:pharmacology*; D002413:Cations, Divalent; D003300:Copper / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008054:Lipid Peroxides / Q000097:blood*; D008345:Manganese / Q000494:pharmacology*; D010545:Peroxides / Q000494:pharmacology*
D002413:Cations, Divalent; D008054:Lipid Peroxides; D010545:Peroxides; D008345:Manganese; D003300:Copper; C029892:cupric chloride; D001585:Benzoyl Peroxide