Evidence to suggest that the spontaneous release of acetylcholine from rat hippocampal tissue is carrier-mediated.
The effect of L- and D-stereoisomers of 2-(4-phenylpiperidino) cyclohexanol (AH 5183) on the spontaneous release of acetylcholine (ACh) from rat hippocampal tissue was studied. L-AH 5183 was approximately 100 times more potent than was D-AH 5183 in reducing spontaneous ACh release. Spontaneous ACh release was also temperature dependent. These results may suggest that the spontaneous release of ACh from brain tissue is carrier-mediated.
Ivy
M T
MT
Department of Pharmacology, Texas Tech University Health Sciences Center, Lubbock 79430.
Carroll
P T
PT
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology*; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010880:Piperidines; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013237:Stereoisomerism
D009467:Neuromuscular Depolarizing Agents; D010880:Piperidines; C006189:vesamicol; D010622:Phencyclidine; D000109:Acetylcholine