title: Antitussive action of the new anilide derivative vadocaine hydrochloride compared with codeine phosphate in four animal models.
abstract: Vadocaine hydrochloride (2',4'-dimethyl-6'-methoxy-3-(2-methylpiperidyl) propionanilide hydrochloride, OR K-242-HCl; INN: vadocaine) is a novel antitussive compound structurally resembling local anaesthetics. Its antitussive profile was studied in several animal models. In guinea-pigs, vadocaine reduced by about 70% the cough episodes induced by sulphur dioxide or ammonia. The effective dose was 2.5 mg/kg p.o., and codeine phosphate was less effective. In cats, vadocaine (3 mg/kg i.v.) inhibited by about 80% for 10 min the cough reflex initiated by mechanical irritation of the trachea. When vadocaine was given via the vertebral artery, it was about 10 times more active than by the intravenous route. Codeine was 3 times as active as vadocaine by both routes. This result indicates an important central component in the antitussive action of vadocaine. In another cat model, 5 mg/kg of vadocaine was somewhat weaker than 1 mg/kg of codeine in inhibiting the cough caused by electrical stimulation of the laryngeal nerve (Domenjoz' method). In dogs, both oral and intravenous doses of 6 mg/kg of vadocaine and 2 mg/kg of codeine were approximately equiactive, inhibiting by 60-80% the cough induced by electrical stimulation of the trachea. Concentrations of vadocaine in serum were around 1 microgram/ml during oral administration. By both routes, the antitussive activity (inhibition of cough by 50% or more) lasted at least 2 h. Vadocaine caused local anaesthesia in the guinea-pig wheal preparation at concentrations of 0.25% and 0.5%, and on the guinea-pig cornea at 0.5%. Duration of anaesthesia was longer than that of lidocaine. Vadocaine did not affect the guinea-pig tracheal strip preparation.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Orion Corporation Ltd., Orion Pharmaceutica, Research Centre, Espoo, Finland.
authors.forename: P T
authors.initials: PT
authors.lastname: Männistö
authors.forename: P
authors.initials: P
authors.lastname: Karttunen
authors.forename: S
authors.initials: S
authors.lastname: Lahovaara
authors.forename: E
authors.initials: E
authors.lastname: Nissinen
authors.forename: J E
authors.initials: JE
authors.lastname: Davies
authors.forename: D R
authors.initials: DR
authors.lastname: Algate
authors.forename: M W
authors.initials: MW
authors.lastname: Baines
mesh_terms: D000779:Anesthetics, Local; D000818:Animals; D000996:Antitussive Agents / Q000494:pharmacology*; D002415:Cats; D003061:Codeine / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007509:Irritants; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects
chemical_list: D000779:Anesthetics, Local; D000996:Antitussive Agents; D007509:Irritants; D010880:Piperidines; C051410:vadocaine; D003061:Codeine