Toxicity in uremia. 1. Correlation between PTH levels and depressed cell proliferation.
Cell proliferation is significantly depressed in uremia; to assess the influence of PTH on it, normal lymphocytes were cultured in presence of uremic patients' serum with low or high plasma PTH levels (Group A; PTH less than 2.5 ng/ml; Group B: PTH greater than 12 ng/ml), and serum of normal subjects (Group C). Cell proliferation was lowered by serum from both groups (p A vs C less than 0.004; p B vs C less than 0.001). However, the depressing effect was more evident when group B serum was employed (p A vs B less than 0.002).
Esposito
R
R
Institute of Internal Medicine and Nephrology, 1st Faculty, University of Naples, Italy.
Manzo
M
M
Hohenegger
M
M
Pluvio
M
M
Lanzetti
N
N
Perna
N
N
Romano-Carratelli
C
C
Giordano
C
C
D002455:Cell Division; D003603:Cytotoxins; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D010281:Parathyroid Hormone / Q000032:analysis / Q000502:physiology*; D014511:Uremia / Q000378:metabolism*
D003603:Cytotoxins; D010281:Parathyroid Hormone