title: Antiarrhythmic action of naloxone: direct, non-opiate effect on the rat heart.
abstract: The opiate antagonist naloxone reduced the incidence and severity of cardiac arrhythmia induced in rats by intracarotid administration of adrenaline. Naloxone also reversed the adrenaline-induced arrhythmia in isolated heart preparations, suggesting a local antiarrhythmic action of the opiate antagonist. Similar effects were obtained with the (+) stereoisomer of naloxone which is inactive as an opiate antagonist. Thus, the direct action of naloxone at the rat heart is probably not mediated by opiate receptors.
authors.affiliation: Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Sarne
authors.forename: I
authors.initials: I
authors.lastname: Hochman
authors.forename: M
authors.initials: M
authors.lastname: Eshed
authors.forename: E
authors.initials: E
authors.lastname: Oppenheimer
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D004562:Electrocardiography; D004837:Epinephrine; D066298:In Vitro Techniques; D009270:Naloxone / Q000627:therapeutic use*; D051381:Rats; D013237:Stereoisomerism
chemical_list: D009270:Naloxone; D004837:Epinephrine