title: A combination therapy of vitamin K1 and bile acid on hemorrhagic diathesis in patients with decompensated liver cirrhosis.
abstract: This paper presents a study of treatment involving vitamin K1 (VK1) accompanied by bile acids for hemorrhagic diathesis that was applied 42 times in 35 patients with decompensated liver cirrhosis. The hepaplastin test (HPT) value showed no change during the administration of VK1 alone. The HPT value elevated significantly, however, after the administration of VK1 with bile acid, especially when using ursodeoxycholic acid (UDCA). The HPT value in patients treated with VK1 in addition to UDCA before treatment with 53.2% +/- 10.2% (mean +/- SD) and after that for 2.1 +/- 1.1 months (mean +/- SD) with 74.7 +/- 16.8% showed a significant difference (p less than 0.001). On the other hand, no significant difference was noted between the HPT value of 57.2 +/- 13.6% before and that of 62.9 +/- 13.9% after the treatment in patients treated using VK1 in conjunction with chenodeoxycholic acid (CDCA). These results indicate that the therapy incorporating VK1 and bile acid, especially UDCA, is useful for reducing the hemorrhagic tendency in patients with decompensated liver cirrhosis who show no improvement using VK1 alone.
authors.affiliation: Department of Internal Medicine, Urayasu Hospital of Juntendo University School of Medicine, Chiba, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nambu
authors.forename: T
authors.initials: T
authors.lastname: Iijima
mesh_terms: D002635:Chenodeoxycholic Acid / Q000627:therapeutic use*; D003840:Deoxycholic Acid / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D005260:Female; D006474:Hemorrhagic Disorders / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*; D014812:Vitamin K / Q000627:therapeutic use*
chemical_list: D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; D014812:Vitamin K; D014580:Ursodeoxycholic Acid