Long-term carcinogenicity bioassay on vinylidene chloride administered by inhalation to Sprague-Dawley rats. New results.
Vinylidene chloride was administered by inhalation, 7 hours daily, 5 days weekly, at the concentration of 100 and 0 ppm, to Sprague-Dawley rats. The treatment was started on 13-week-old breeders, and male and female offspring (12-day embryos). The breeders and some of the offspring were exposed for 104 weeks; the other offspring were exposed for 15 weeks only. An increased incidence was found of malignant tumors and of leukemias, particularly in offspring treated for 104 weeks.
Cotti
G
G
Institute of Oncology, F. Addarii, Bologna, Italy.
Maltoni
C
C
Lefemine
G
G
D000280:Administration, Inhalation; D000818:Animals; D001681:Biological Assay; D004000:Dichloroethylenes / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D008297:Male; D008970:Molecular Weight; D009152:Mutagenicity Tests; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004000:Dichloroethylenes; D006843:Hydrocarbons, Chlorinated; C029297:vinylidene chloride