Effect of various classes of drugs on complete ischemia induced by decapitation and cyanide intoxication in mice.
Effects of various classes of drugs on complete ischemia (gasping) induced by decapitation and cyanide intoxication in mice were investigated. The average gasping duration in complete ischemia and survival time in potassium cyanide injection of control mice were 21.0 +/- 0.1 and 26.1 +/- 0.4 sec (mean +/- SEM), respectively. Some antidepressants, neuroleptics and tranquilizers significantly and dose-dependently prolonged the duration of gasping and survival time, and decreased locomotor activity. Vincamine and its analogues are markedly effective for treating cyanide intoxication. It is conceivable that this is a characteristic phenomenon for vincamine. Xanthine analogues significantly and dose-dependently shortened the duration of gasping and survival time and increased locomotor activity. These results suggest that the cerebral protecting effect primarily relates to the cerebral energy demand.
Araki
H
H
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Karasawa
Y
Y
Nojiri
M
M
Aihara
H
H
D000818:Animals; D001921:Brain / Q000503:physiopathology*; D003486:Cyanides / Q000506:poisoning*; D007511:Ischemia / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects
D003486:Cyanides