title: Personality traits and mental prognosis in patients with congenital hypothyroidism not treated from early life.
abstract: Congenital hypothyroidism, if not treated in very early life, severely impairs the neuropsychological development of affected subjects. We have carried out a detailed analysis of cognitive functioning and personality traits in 18 congenital hypothyroid patients treated late and/or unproperly. Significant cognitive defects were observed, the most important being a defective learning ability and an impaired capacity to judge socially significant events and to project complex actions in a temporal perspective. A mental retardation (IQ less than 70) was observed in 8/18 (44.4%) of these patients, a moderate intellective deficit in 5/18 (27.8%) and an IQ greater than 85 in the remaining 5 patients (27.8%). These data indicate that the mental defect of congenital hypothyroid patients may be overestimated. The patients personality was characterized by dependence on the mother, worrying about their body, maladjustment and socialization problems. Since the intellective prognosis of these patients may significantly improve when the environmental conditions are optimized, social and psychological help must always be suggested.
authors.affiliation: Cattedra di Endocrinologia e Patologia Costituzionale, Università di Catania, Ospedale Garibaldi, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Mendorla
authors.forename: L
authors.initials: L
authors.lastname: Sava
authors.forename: F
authors.initials: F
authors.lastname: Calaciura
authors.forename: E
authors.initials: E
authors.lastname: Lisi
authors.forename: S
authors.initials: S
authors.lastname: Castorina
authors.forename: R
authors.initials: R
authors.lastname: Vigneri
mesh_terms: D000293:Adolescent; D002648:Child; D003409:Congenital Hypothyroidism; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000503:physiopathology*; D007360:Intelligence; D007361:Intelligence Tests; D008297:Male; D010554:Personality Disorders / Q000503:physiopathology*; D011379:Prognosis