Effect of nicotine on central GABAergic system.
1. The acute and chronic effects of nicotine (1.5 mg/kg/day) on the striatal and mesolimbic GABAergic systems were examined in the rat. 2. Despite altering the striatal DAergic activity, neither acute nor chronic administration of nicotine significantly affected the GABAergic system. 3. The nicotine treatment did not alter the ability of muscimol to inhibit the hyperactivity elicited by apomorphine. 4. Similarly, the levels of GABA in striata and nucleus accumbens remained unchanged.
Fung
Y K
YK
University of Nebraska Medical Center, College of Dentistry, Department of Oral Biology, Lincoln 68583-0740.
Reed
J A
JA
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects*; D008032:Limbic System / Q000187:drug effects*; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D009538:Nicotine / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D009538:Nicotine; D001058:Apomorphine