title: Diaphragm disease: pathology of disease of the small intestine induced by non-steroidal anti-inflammatory drugs.
abstract: Operative small bowel resection specimens received over a period of 16 years were reviewed to assess whether any intestinal disease could be directly attributed to the use of non-steroidal anti-inflammatory drugs (NSAID). Seven cases of intestinal disease associated with the use of NSAID were identified, all of which occurred in the final six years of the survey, which may reflect the increasing use of these compounds. A spectrum of patterns was found from multiple pathognomonic ileal mucosal diaphragms to broad strictures similar to those seen as a complication of enteric potassium. It seems likely that the formation of diaphragm lesions requires an additional factor, but what is not known as yet is whether the effects of NSAID are local or systemic.
authors.affiliation: Department of Histopathology, Northwick Park Hospital, Harrow, Middlesex.
authors.forename: J
authors.initials: J
authors.lastname: Lang
authors.forename: A B
authors.initials: AB
authors.lastname: Price
authors.forename: A J
authors.initials: AJ
authors.lastname: Levi
authors.forename: M
authors.initials: M
authors.lastname: Burke
authors.forename: J M
authors.initials: JM
authors.lastname: Gumpel
authors.forename: I
authors.initials: I
authors.lastname: Bjarnason
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003424:Crohn Disease / Q000473:pathology; D006099:Granuloma / Q000473:pathology; D006801:Humans; D007077:Ileal Diseases / Q000139:chemically induced* / Q000473:pathology; D007082:Ileum / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal