title: Enhancement of theophylline clearance by intravenous albuterol.
abstract: Co-administration of intravenous albuterol and theophylline resulted in increased theophylline clearance in a child with severe asthma. This required a threefold increase in theophylline dosage to maintain therapeutic serum theophylline concentrations. The possible effect of intravenous albuterol on theophylline metabolism was further supported by a 50 percent decrease in theophylline clearance upon discontinuation of albuterol and a second increase in its clearance when albuterol was readministered. To the best of our knowledge, this is the first documentation of enhanced theophylline clearance by albuterol.
authors.affiliation: Department of Pediatrics, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Amirav
authors.forename: Y
authors.initials: Y
authors.lastname: Amitai
authors.forename: A
authors.initials: A
authors.lastname: Avital
authors.forename: S
authors.initials: S
authors.lastname: Godfrey
mesh_terms: D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D013224:Status Asthmaticus / Q000378:metabolism*; D013806:Theophylline / Q000493:pharmacokinetics*
chemical_list: D013806:Theophylline; D000420:Albuterol