title: An antineuronal autoantibody in paraneoplastic opsoclonus.
abstract: Sera from 7 patients with paraneoplastic opsoclonus were examined for antineuronal autoantibodies. An antibody against neuronal nuclei was found in serum from a patient with breast cancer, opsoclonus, and ataxia. This antibody recognized 53- to 61-kDa and 79- to 84-kDa antigens in immunoblots of neurons. Antineuronal antibodies were not found in other patients with paraneoplastic opsoclonus.
authors.affiliation: Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
authors.forename: C
authors.initials: C
authors.lastname: Budde-Steffen
authors.forename: N E
authors.initials: NE
authors.lastname: Anderson
authors.forename: M K
authors.initials: MK
authors.lastname: Rosenblum
authors.forename: F
authors.initials: F
authors.lastname: Graus
authors.forename: D
authors.initials: D
authors.lastname: Ford
authors.forename: B J
authors.initials: BJ
authors.lastname: Synek
authors.forename: S H
authors.initials: SH
authors.lastname: Wray
authors.forename: J B
authors.initials: JB
authors.lastname: Posner
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001943:Breast Neoplasms / Q000150:complications / Q000276:immunology*; D002277:Carcinoma / Q000150:complications / Q000276:immunology*; D002531:Cerebellum / Q000276:immunology*; D005133:Eye Movements; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009474:Neurons / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000276:immunology*
chemical_list: D001323:Autoantibodies