[Neurophysiological analysis of the correction by nootropic substances of disorders in the bioelectric activity of the brain in animals during chronic administration of ethanol].
The influence of some drugs (piracetam and 3-oxypyridine derivative) having a nootropic effect on ethanol-induced changes of bioelectrical activity was studied in experiments on freely moving rats. Discontinuation of ethanol administration (1, 2 g/kg, i.p. for 40 days) has been found to provoke destructuring of Fourier's spectral power of sensorimotor cortex and dorsal hippocamp on the EEG. Long-term administration of piracetam or 3-oxypyridine derivative (300 and 50 mg/kg, respectively, i.p. for 40 days) with ethanol has a protective effect and normalizes EEG at the cortical level. The authors discuss possible neurophysiological mechanisms of nootropic drug action in ethanol-induced pathology.
Krapivin
S V
SV
Bogdanov
N N
NN
Voronin
K E
KE
D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D004569:Electroencephalography; D006624:Hippocampus / Q000187:drug effects; D008297:Male; D010847:Picolines / Q000627:therapeutic use*; D010889:Piracetam / Q000627:therapeutic use*; D011760:Pyrrolidinones / Q000627:therapeutic use*; D051381:Rats; D013003:Somatosensory Cortex / Q000187:drug effects
D010847:Picolines; D011760:Pyrrolidinones; C009820:6-methyl-2-ethyl-3-hydroxypyridine; D010889:Piracetam
Neĭrofiziologicheskiĭ analiz korrektsii nootropnymi sredstvami narusheniĭ bioélektricheskoĭ aktivnosti mozga zhivotnykh pri khronicheskom vvedenii étanola.