Effect of cytostatics on liver retinol store in rat.
The effect of the cytostatics doxorubicin, 6-thioguanine and cytarabine on retinol store in rat liver was examined. When rats were treated with pharmacological doses of the combination of doxorubicin and 6-thioguanine for 10 days, the content of retinol in the liver was reduced by about 33%. In a longer term experiment, doxorubicin and cytarabine given separately reduced the retinol store by 33% and 11%, respectively, while doxorubicin and 6-thioguanine given in combination reduced retinol in liver by 31%. For one of the cytostatics (doxorubicin) the effects on plasma retinol and on acyl CoA:retinol acyltransferase (ARAT) activity in small intestine were also examined. Both were transiently reduced during the experiment.
Wathne
K O
KO
Institute for Nutrition Research, School of Medicine, University of Oslo, Norway.
Blomhoff
R
R
Norum
K R
KR
D000217:Acyltransferases / Q000032:analysis; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003561:Cytarabine / Q000009:adverse effects / Q000494:pharmacology*; D004317:Doxorubicin / Q000009:adverse effects / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D051142:Retinol O-Fatty-Acyltransferase; D013866:Thioguanine / Q000009:adverse effects / Q000494:pharmacology*; D014801:Vitamin A / Q000097:blood / Q000378:metabolism*
D003561:Cytarabine; D014801:Vitamin A; D004317:Doxorubicin; D000217:Acyltransferases; D051142:Retinol O-Fatty-Acyltransferase; D013866:Thioguanine