Reabsorption kinetics of albumin from pleural space of dogs.
The reabsorption of albumin from the pleural space was measured in eight dogs receiving 0.5 ml intrapleural injection of 131I-labeled albumin and a simultaneous intravenous injection of 125I-labeled albumin. Plasma curves for both tracers were obtained over 24 h. The 125I-albumin curve served as input function of albumin for interstitial spaces, including pleura, whereas the 131I-albumin curve represented the output function from pleural space. The frequency function of albumin transit times from pleural space to plasma was obtained by deconvolution of input-output plasma curves. Plasma recovery of 131I-albumin was complete by 24 h, and the mean transit time from pleura to plasma averaged 7.95 +/- 1.57 (SD) h. Albumin reabsorption occurred mainly via lymphatics as indicated by experiments in 16 additional dogs in which their right lymph ducts or thoracic ducts were ligated before intrapleural injection. A pleural lymph flow of 0.020 +/- 0.003 (SD) ml.kg-1.h-1 was estimated, which is balanced by a comparable filtration of fluid into the pleural space. This suggests that, under physiological conditions, the subpleural lymphatics represent an important control mechanism of pleural liquid pressure.
Miniati
M
M
National Research Council Institute of Clinical Physiology, University of Pisa, Italy.
Parker
J C
JC
Pistolesi
M
M
Cartledge
J T
JT
Martin
D J
DJ
Giuntini
C
C
Taylor
A E
AE
D000042:Absorption; D000818:Animals; D004285:Dogs; D006801:Humans; D007457:Iodine Radioisotopes; D008433:Mathematics; D008954:Models, Biological; D010994:Pleura / Q000378:metabolism*; D012709:Serum Albumin / Q000493:pharmacokinetics*; D013045:Species Specificity
D007457:Iodine Radioisotopes; D012709:Serum Albumin