A pharmacological study of hibernation in rodents.
1. Hamsters and ground squirrels in deep hibernation were infused intra-arterially with drugs. 2. Norepinephrine and epinephrine sometimes caused arousal, sometimes transitory effects. 3. Adrenalectomy did not affect arousal. L-DOPA and amphetamine produced a slow arousal. 4. Arousal was blocked with alpha-methyltyrosine and the block was released with L-DOPA, DL- and L-threo-DOPS resulted in arousal and bromocriptine did not cause arousal, indicating that dopamine was not necessary for arousal. 5. Isoproterenol caused a transient increase in heart rate which was blocked by propranolol. 6. Phenylephrine caused vasoconstriction, but did not result in arousal. 7. No drug increased the sensitivity to peripheral stimuli during hibernation.
Lyman
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CP
Concord Field Station, Harvard University, Bedford, MA 01730.
O'Brien
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RC
D000315:Adrenalectomy; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D006224:Cricetinae; D015103:Droxidopa / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006605:Hibernation / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D008647:Mesocricetus; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D012589:Sciuridae
D010656:Phenylephrine; D001971:Bromocriptine; D007980:Levodopa; D000661:Amphetamine; D015103:Droxidopa; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine