title: Evolution of recruitment at different frequencies during the development of endolymphatic hydrops in the guinea pig.
abstract: The study of human temporal bones has identified endolymphatic hydrops as a common feature of several diseases. In particular it is systematically found in those bones removed from patients with premortem Menière's disease. Menière's disease is known to induce sensorineural pathology with recruitment, which changes with the evolution of the hearing loss, and is suspected to induce a cochlear conductive loss by a possible increase in static pressure of endolymph. Amplitude/intensity functions of sensorineural responses can reflect recruitment and/or conduction loss. Experimentally induced hydrops in animals provokes cochlear physiological alterations, some of which closely resemble certain features of Menière's disease. In the present study using a guinea-pig animal model, we have examined amplitude/intensity functions at the round window for cochlear microphonics (RWCM), summating potentials (RWSP) and action potentials (CAP) at different stages of hearing loss in experimentally induced hydrops. During the period of fluctuating thresholds there was reduction of maximal RWCM amplitude, no change in RWSP and recruitment on the CAP. At a later stage when the audiogram was flat and fluctuations were no longer seen, RWCM remained unchanged. At this time RWSP could show recruitment while CAP amplitudes at all intensities were reduced, indicating either a cochlear conductive loss and/or a general depression of neural activity.
authors.affiliation: INSERM Unité 229, Université Bordeaux II, Hôpital Pellegrin, France.
authors.forename: K C
authors.initials: KC
authors.lastname: Horner
authors.forename: Y
authors.initials: Y
authors.lastname: Cazals
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007758:Ear, Inner; D004487:Edema / Q000150:complications / Q000503:physiopathology*; D004711:Endolymphatic Duct; D005072:Evoked Potentials, Auditory; D006168:Guinea Pigs; D034381:Hearing Loss / Q000503:physiopathology*; D006314:Hearing Loss, Conductive / Q000209:etiology / Q000503:physiopathology*; D006319:Hearing Loss, Sensorineural / Q000209:etiology / Q000503:physiopathology*; D007759:Labyrinth Diseases / Q000150:complications / Q000503:physiopathology*; D008575:Meniere Disease / Q000150:complications; D012000:Recruitment Detection, Audiologic; D013997:Time Factors