Differential regulation by glucocorticoids of mouse pro alpha 2(I) and pro alpha 1(III) DNA-binding proteins.
Multiple procollagen-specific DNA-binding proteins were identified for the alpha 2(I) and the alpha 1(III) procollagen promotor containing gene fragments. The proteins are gene-specific, differing in their relative molecular weights and relative binding specificities. A major finding was the increased DNA-binding with specificity for the procollagen promoter containing DNAs by several nonhistone nuclear proteins in mouse embryo fibroblasts treated with dexamethasone. The previously reported coordinate decrease of type I and type III procollagens by glucocorticoids may involve differential regulation by glucocorticoids of procollagen gene specific DNA-binding proteins.
Sweeney
C
C
Department of Biochemistry, College of Medicine, University of Vermont, Burlington 05405.
Cutroneo
K R
KR
D000818:Animals; D002460:Cell Line; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology*; D006657:Histones / Q000378:metabolism; D051379:Mice; D009687:Nuclear Proteins / Q000378:metabolism; D011347:Procollagen / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012867:Skin; D012965:Sodium Chloride / Q000494:pharmacology
D004268:DNA-Binding Proteins; D006657:Histones; D009687:Nuclear Proteins; D011347:Procollagen; D012965:Sodium Chloride; D003907:Dexamethasone; D004247:DNA