[20 years' use of the diphtheria-pertussis-tetanus vaccine].
Between 1966 and 1982, a triple DPT vaccine was studied in France in 1,871 infants between the ages of 3 and 5 months. The study covered tolerance and serological efficacy of two immunization schedules using 2 or 3 initial injections. Computerized analysis of the 877 complete files showed satisfactory tolerance of this association and the serological efficacy of 2 initial doses of tetanus and diphtheria vaccines. Pertussis immunization is only effective after 3 injections. The presence of maternal antibodies when the first injection is given only decreases the immune response of diphtheria vaccine.
Fillastre
C
C
Centre International de l'Enfance, Château de Longchamp, Paris, France.
Guerin
N
N
Ajjan
N
N
Triau
R
R
D000914:Antibodies, Viral / Q000032:analysis; D004168:Diphtheria Toxoid / Q000009:adverse effects / Q000276:immunology*; D004338:Drug Combinations; D005602:France; D006801:Humans; D007223:Infant; D010567:Pertussis Vaccine / Q000009:adverse effects / Q000276:immunology*; D013745:Tetanus Toxoid / Q000009:adverse effects / Q000276:immunology*; D013997:Time Factors
D000914:Antibodies, Viral; D004168:Diphtheria Toxoid; D004338:Drug Combinations; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid
Vingt années d'utilisation du vaccin diphtérique-tétanique-coquelucheux (DTcoq).