Use of adult fibroblasts coupled to muramyl dipeptide to induce antitumor immunity.
Murine splenocytes immunized in vitro against syngeneic adult kidney fibroblasts coupled sequentially with a glycylglycylcystamide spacer, and the p-nitrophenyl ester of muramyl dipeptide developed direct cell-mediated cytotoxicity to the immunizing cells which cross-reacted against syngeneic fibrosarcoma cells. These results extended previous observations showing the reverse pattern of cross-reactivity. Derivatized kidney fibroblasts also gave protection in an in vivo protection-challenge experiment performed with the tumor cells. A hypothesis is presented relating this kind of autoimmunity to tumor immunity.
Eggers
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Department of Neurology, SUNY Health Science Center, Brooklyn 11203.
D000119:Acetylmuramyl-Alanyl-Isoglutamine; D000818:Animals; D002460:Cell Line; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D005347:Fibroblasts / Q000276:immunology*; D005354:Fibrosarcoma / Q000628:therapy*; D007167:Immunotherapy; D007668:Kidney / Q000166:cytology; D008223:Lymphoma / Q000628:therapy*; D051379:Mice; D008819:Mice, Nude
D000119:Acetylmuramyl-Alanyl-Isoglutamine