Effect of pre-feeding ammonium acetate on food intake of rats fed high protein diets.
The effect on intake of a 75% casein diet after prefeeding for one week a 6% casein basal diet with additional 0%, 2%, 5%, 8% or 15% ammonium acetate was examined in rats trained to eat in three hours per day. Food intake was measured from 0-15, 15-30, 30-90, and 90-180 minutes for the first two days that the ammonium acetate diets were presented. Rats eating 5% and 8% or 15% ammonium acetate diet depressed their intake significantly for one day and for four days respectively. Rats eating 2%, 5%, 8%, or 15% ammonium acetate diets depressed their intake significantly from 0-30 minutes. When presented with the 75% casein diet, rats prefed 0% to 5% and 8% and 15% ammonium acetate diets ate 55% to 58% and 72% and 94% of their respective baseline intakes. It is suggested that prefeeding 15% ammonium acetate apparently induces sufficient metabolic adaptation to ammonia intake so that the rat is able to offset the metabolic consequences of intake of the 75% casein diet, thus preventing the usual food intake depressing effect of the high protein diet.
Semon
B A
BA
Department of Physiological Sciences, School of Veterinary Medicine, University of California, Davis 95616.
Leung
P M
PM
Rogers
Q R
QR
D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D002364:Caseins; D004044:Dietary Proteins / Q000008:administration & dosage*; D004435:Eating / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D002364:Caseins; D004044:Dietary Proteins; C018824:ammonium acetate