title: Distribution of serotypes and antibiotic resistance among pneumococci in Northern Ireland.
abstract: Altogether, 488 consecutive strains of Streptococcus pneumoniae isolated from clinical specimens were serotyped and their antibiotic susceptibility determined. Of all strains isolated, 89.7% (90.6% for strains isolated from patients with serious infection) were of types present in the new polyvalent (23-valent) pneumococcal vaccine. Four strains showed reduced susceptibility to penicillin (minimum inhibitory concentration 0.1-1.0 mg/l). Two of those strains (both serotype 23) were also of intermediate susceptibility to other antibiotics (ampicillin, cephradine, chloramphenicol and tetracycline) but were sensitive to erythromycin. A significant proportion (12%) was resistant to tetracycline.
authors.affiliation: Bacteriology Laboratory, Belfast City Hospital, U.K.
authors.forename: A C
authors.initials: AC
authors.lastname: Lafong
authors.forename: E
authors.initials: E
authors.lastname: Crothers
authors.forename: K B
authors.initials: KB
authors.lastname: Bamford
authors.forename: P J
authors.initials: PJ
authors.lastname: Rooney
mesh_terms: D000372:Agglutination Tests; D000667:Ampicillin / Q000494:pharmacology; D002515:Cephradine / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D003378:Counterimmunoelectrophoresis; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D007841:Latex Fixation Tests; D009660:Northern Ireland; D010406:Penicillins / Q000494:pharmacology; D011008:Pneumococcal Infections / Q000382:microbiology*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D010406:Penicillins; D004917:Erythromycin; D002701:Chloramphenicol; D000667:Ampicillin; D002515:Cephradine; D013752:Tetracycline