title: Reversal of prolonged postoperative muscle rigidity by dantrolene: a case report.
abstract: The use of dantrolene to reverse severe unexplained postanaesthetic muscle rigidity in a previously "healthy" 13-year-old male is described. Anaesthesia was induced with thiopentone. After intubation with pancuronium, the patient had an entirely uneventful nitrous oxide, oxygen and halothane anaesthetic. Immediately following reversal of the relaxant, the patient developed generalized muscle tightness and rigidity involving the trunk and extremities. This was prolonged and severe enough to interfere with adequate ventilation. The patient also had a prolonged recovery from the anaesthetic. After ruling out malignant hyperthermia and some other causes of rigidity, a tentative diagnosis of myotonia was made. The symptoms responded to IV dantrolene in a total dose of 2.0 mg.kg-1. Further testing failed to establish a definite diagnosis. Dantrolene could be a useful drug in treating such unexplained muscle rigidity.
authors.affiliation: Department of Anesthesiology, Children's Hospital, Detroit, Michigan 48201.
authors.forename: S K
authors.initials: SK
authors.lastname: Dhandha
mesh_terms: D000293:Adolescent; D000768:Anesthesia, General; D000769:Anesthesia, Inhalation; D003620:Dantrolene / Q000627:therapeutic use*; D006221:Halothane; D006801:Humans; D008297:Male; D009127:Muscle Rigidity / Q000188:drug therapy* / Q000209:etiology; D009609:Nitrous Oxide; D010197:Pancuronium; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology; D013874:Thiopental
chemical_list: D003620:Dantrolene; D010197:Pancuronium; D013874:Thiopental; D009609:Nitrous Oxide; D006221:Halothane