title: A study of HLA class II antigens in an Italian paediatric population with coeliac disease.
abstract: One hundred and twenty-one Italian children with coeliac disease (CD) have been compared with a control population from the same geographical area for the distribution of HLA-DR and DQ antigens. The pattern of an increase in DR3, DR7, and of heterozygotes DR5/7 was associated with an excess of heterozygotes DQw2/DQw3 in the CD population. These findings suggest that epitopes determined by specific combinations of DQ alpha and beta chains (combinatorial determinants) predispose to the disease.
authors.affiliation: I. Cattedra Genetica Medica, Università degli Studi La Sapienza, Roma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Morellini
authors.forename: S
authors.initials: S
authors.lastname: Trabace
authors.forename: M C
authors.initials: MC
authors.lastname: Mazzilli
authors.forename: P
authors.initials: P
authors.lastname: Lulli
authors.forename: S
authors.initials: S
authors.lastname: Cappellacci
authors.forename: M
authors.initials: M
authors.lastname: Bonamico
authors.forename: I
authors.initials: I
authors.lastname: Margarit
authors.forename: E
authors.initials: E
authors.lastname: Gandini
mesh_terms: D000293:Adolescent; D002446:Celiac Disease / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006681:HLA-D Antigens / Q000032:analysis*; D006801:Humans; D007223:Infant; D007558:Italy; D008297:Male
chemical_list: D006681:HLA-D Antigens