Antagonist action of imidazobenzodiazepine Ro 15-4513 on ethanol-induced alterations of saccadic eye movements in the pigmented rat.
Following an intraperitoneal injection of ethanol (1 g/kg), spontaneous saccades performed by pigmented rats showed a backward post-saccadic drift which was still present 45 min after the administration. When 5 mg/kg of Ro 15-4513 were injected, 15 min after ethanol, there was an immediate remarkable reduction in post-saccadic drift amplitude, with a full recovery in about 30 min after Ro 15-4513 administration. This drug is thus able to reverse the effect of ethanol and to restore effectively a mechanism of motor integration.
Rossi
F
F
Department of Human Anatomy and Physiology, University of Turin, Italy.
Chelazzi
L
L
Tempia
F
F
Strata
P
P
D000818:Animals; D001386:Azides / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005133:Eye Movements / Q000187:drug effects*; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D012438:Saccades / Q000187:drug effects*; D013997:Time Factors
D001386:Azides; D001569:Benzodiazepines; D000431:Ethanol; C042957:Ro 15-4513