title: The role of the pyriform cortex in the generation of interictal spikes in the kindled preparation.
abstract: The development of interictal spikes (IIS) was monitored during amygdala or pyriform cortex kindling in a series of 4 experiments. It was found that (1) spike-like transients were often present in the pyriform cortex EEG before kindling had begun; (2) these transients developed progressively into large amplitude and complex IIS as kindling proceeded; (3) the pyriform cortex IIS continued to show the greatest proportion of earliest onset spikes in most animals after kindling was completed; (4) other sites (including the ventral, but not the dorsal hippocampus) gradually developed the capacity to generate IIS as kindling progressed; (5) although specific sites within the pyriform cortex may serve as a generator, their location along the longitudinal axis of the pyriform lobe varied from animal to animal (and did not appear to depend upon the location of the kindling electrode); (6) although there often appeared to be 2 spike types, based on the polarity of the first component, there were also transitional waveforms, raising the possibility that they were variations on a single spike type, and (7) the IIS were often preceded, usually in the pyriform cortex, by reliable pre-spike events (smaller spikes or a 'ripple' on the EEG).
authors.affiliation: Department of Psychology, McMaster University, Hamilton, Ont., Canada.
authors.forename: R J
authors.initials: RJ
authors.lastname: Racine
authors.forename: M
authors.initials: M
authors.lastname: Mosher
authors.forename: E W
authors.initials: EW
authors.lastname: Kairiss
mesh_terms: D000679:Amygdala / Q000503:physiopathology*; D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology*; D004558:Electric Stimulation; D005071:Evoked Potentials; D007696:Kindling, Neurologic; D051381:Rats