Effects of age, sex and breed on antipyrine disposition in calves.
In domestic animals relatively little is known about the functions of hepatic microsomal enzymes and their role in biotransformation. In this study, antipyrine was used to assess microsomal oxidative function and particularly to determine the effect of age, sex and breed on drug metabolising enzymes. At birth, the elimination rate of antipyrine was very low as reflected by a half-life of 24 hours. The first two months of life were characterised by a steady decrease of antipyrine half-life values of three to four hours being reached at six months. The decrease observed during early life was not identical in the two breeds used in this experiment. By six months the Friesian calves eliminated antipyrine twice as fast as the Blue White Belgian (BWB) breed: 2.1 +/- 0.3 hours and 4.9 +/- 0.3 hours, respectively. The BWB breed is characterised by muscular hypertrophy and by a relative imbalance in muscle:body ratio. The apparent volume of distribution of antipyrine did not vary with age, sex and breed. No differences in antipyrine clearance were found between male and female calves.
Depelchin
B O
BO
Department of Pharmacology, Faculty of Veterinary Medicine, University of Liège, Brussels, Belgium.
Bloden
S
S
Michaux
C
C
Ansay
M
M
D000367:Age Factors; D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics*; D001711:Biotransformation; D002417:Cattle / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D010084:Oxidation-Reduction; D010375:Pedigree; D012737:Sex Factors
D000983:Antipyrine