title: Sensitivity of a human oral carcinoma cell line to retinoic acid.
abstract: We have examined the effect of retinoic acid (RA) on proliferation of KB cells in both anchorage dependent and independent growth conditions. Our study shows that RA can cause a reduction in cell proliferation rate both in monolayer and in agar cultures. After 48 h of exposure to RA, the cells started to assume a flattened appearance and no longer formed multilayers. RA treatment also caused increase in generation time, reduction in saturation density and induced cell-to-substratum adhesiveness. These changes were reversed within 48 h after removal of RA from growth medium. The results show that this cell line is sensitive to RA-induced growth inhibition and morphologic alterations which are generally associated with reduced expression of the malignant phenotype.
authors.affiliation: Department of Tissue Culture, Chittaranjan National Cancer Research Centre, Calcutta, India.
authors.forename: R
authors.initials: R
authors.lastname: Sarkar
authors.forename: S
authors.initials: S
authors.lastname: Kumardas
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D007700:Kinetics; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D014212:Tretinoin