Characteristics of an attenuated Anaplasma marginale of deer origin as an anaplasmosis vaccine.
A fully virulent field Anaplasma marginale isolate, passaged to a splenectomised white tailed deer, lost virulence for cattle after 18 months in the non-bovine host. This attenuated A. marginale produced a mild response in four 18-month-old Holstein steers characterised by an average 2.4% parasitaemia, a 13% drop in PCV and a positive serological response. All vaccinated steers were immune to challenge with a fully virulent, heterologous A. marginale when compared with non-vaccinated controls.
Kuttler
K L
KL
USDA, ARS, University of Idaho, Caldwell 83605.
Zaugg
J L
JL
D000709:Anaplasma / Q000276:immunology* / Q000472:pathogenicity; D000712:Anaplasmosis / Q000517:prevention & control*; D000818:Animals; D001428:Bacterial Vaccines; D002417:Cattle; D003670:Deer / Q000276:immunology; D008297:Male; D012692:Serial Passage; D012756:Sheep / Q000276:immunology; D013156:Splenectomy; D014613:Vaccines, Attenuated; D014774:Virulence
D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated