Preliminary X-ray analysis of crystals of murine adenosine deaminase.
We have obtained single crystals of a cloned mammalian adenosine deaminase (Mr = 41,000), a key enzyme in purine degradation and in normal development of the immune system, that are suitable for high-resolution structural analysis. The crystals belong to the space group C2 with unit cell parameters a = 101.68 A (1 A = 0.1 nm), b = 94.38 A, c = 85.51 A, and beta = 96.54 degrees. The asymmetric unit contains two enzyme molecules.
Wilson
D K
DK
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030.
Rudolph
F B
FB
Harrison
M L
ML
Kellems
R E
RE
Quiocho
F A
FA
D000243:Adenosine Deaminase; D000818:Animals; D051379:Mice; D009700:Nucleoside Deaminases; D014961:X-Ray Diffraction
D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase