Pharmacokinetic disposition in sheep of various vitamin E preparations given orally or intravenously.
1. Increases in plasma tocopherol concentrations were compared in sheep after a single oral administration of (per kg body-weight): 67 mg D- and 91 mg DL-epimers of alpha-tocopherol, and 74 mg D- and 100 mg DL-epimers of alpha-tocopheryl acetate, or intravenous administration of DL-alpha-tocopherol and DL-epimers of DL-alpha-tocopheryl acetate. 2. The results showed that biological availability was higher after D-alpha-tocopherol dosing than after the other forms. Intravenous administration of D-alpha-tocopherol acetate was a more effective way of dosing in sheep than equivalent intravenous amounts of DL-alpha-tocopheryl acetate or DL-alpha-tocopherol.
Hidiroglou
M
M
Animal Research Centre, Agriculture Canada, Ottawa.
Karpinski
K
K
D000284:Administration, Oral; D000818:Animals; D007262:Infusions, Intravenous; D008297:Male; D012756:Sheep; D024505:Tocopherols; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics*; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols