Plasma GRP-like immunoreactivity in healthy and diseased subjects.
Gastrin releasing peptide(GRP)-like immunoreactivity in human plasma was measured using radioimmunoassay of neuromedin C (NMC) in 83 healthy and 58 diseased subjects. In the healthy group, the mean value of fasting GRP-like immunoreactivity was 2.1 +/- 1.4 (mean +/- SD) pmol/L. There was a slight positive correlation between the GRP-like immunoreactivity values and aging. Postprandial serial measurements demonstrated that GRP-like immunoreactivity showed no response to a significant elevation of serum gastrin concentration. The group with chronic renal failure on hemodialysis gave the highest value, 7.1 +/- 2.1 pmol/L (p less than 0.01). There were no statistical differences between the healthy controls and groups with peptic ulcer, liver cirrhosis, diabetes mellitus or carcinomas, although some cancer patients had a marked increase in GRP-like immunoreactivity value.
Haraguchi
Y
Y
First Department of Internal Medicine, Miyazaki Medical College, Japan.
Sakamoto
A
A
Yoshida
T
T
Tanaka
K
K
D000328:Adult; D000368:Aged; D001839:Bombesin / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D019886:Gastrin-Releasing Peptide; D005755:Gastrins / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood; D010437:Peptic Ulcer / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood*; D011863:Radioimmunoassay
D005755:Gastrins; D010446:Peptide Fragments; D010455:Peptides; D019886:Gastrin-Releasing Peptide; C040794:neuromedin C; D001839:Bombesin