2', 5' oligo (A) synthetase levels in interferon-sensitive or resistant breast cancer cells.
The levels of 2', 5' oligo (A) synthetase increase 15-fold when T47D cells are treated with human interferon or with interferon inducers. The results also show that interferon-treated T47D cells contain high levels of 2', 5' oligo (A) synthetase which upon incubation with ATP produces adenine oligonucleotides which are predominantly trimers. In contrast, MCF-7 and BT20 cells whether treated with interferon or not exhibit low 2', 5' oligo (A) synthetase activity.
Kortsaris
A
A
Theagenion Memorial Cancer Institute, Greece.
D015088:2',5'-Oligoadenylate Synthetase / Q000096:biosynthesis*; D001943:Breast Neoplasms / Q000201:enzymology*; D004790:Enzyme Induction; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D011061:Poly A / Q000494:pharmacology; D011066:Poly C / Q000494:pharmacology; D011072:Poly U / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D007370:Interferon Type I; D011061:Poly A; D011072:Poly U; D011066:Poly C; D015088:2',5'-Oligoadenylate Synthetase