[Cholestatic hepatitis caused by ketoconazole].
The authors report a new Ketoconazole-induced hepatitis in which clinical, chemical and histological features show evidence of a cholestatic injury in a 62 yrs-old female recovering once therapy is stopped. In this case-report, delay of onset of the illness is very short for a 200 mg-a-day prescription and no feature leads towards an immune response. This, may be, means that Ketoconazole-induced hepatitis should be led by an idiosyncrasic mechanism. Even if fatal hepatitis are rare, prescriptors have to beware of this therapy.
Bensaude
R J
RJ
Clinique Saint-Grégoire, Tours.
Furet
Y
Y
Autret
E
E
Brottes
H
H
Billard
J L
JL
Breteau
M
M
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000009:adverse effects*; D008875:Middle Aged
D007654:Ketoconazole
Hépatite cholestatique au kétoconazole.