title: [Neurophysiological study of peripheral nerves in newborn infants with congenital hypothyroidism. Value in the surveillance of replacement therapy].
abstract: The authors studied prospectively with electrophysiological means, peripheral nerve maturation of 18 neonates with congenital hypothyroidism compared to 18 controls. Before replacement therapy, a large reduction of sural nerve action potential amplitude and of Hoffmann's reflex was observed. It was accompanied by a moderate reduction in nerve conduction velocity. These results imply a myelinic and even more an axonal pathology. It is related to the anatomical type of hypothyroidism and to serum T4 deficiency. It is transient and disappears after 6 months of hormonal replacement therapy. In conclusion, this study gives new informations on the consequences of congenital hypothyroidism on peripheral nerves.
authors.affiliation: Laboratoire d'Electroencephalographie, Hôpital d'Enfants, CHU Dijon.
authors.forename: M
authors.initials: M
authors.lastname: Giroud
authors.forename: D
authors.initials: D
authors.lastname: Tenenbaum
authors.forename: P
authors.initials: P
authors.lastname: D'Athis
authors.forename: R
authors.initials: R
authors.lastname: Dumas
authors.forename: J L
authors.initials: JL
authors.lastname: Nivelon
mesh_terms: D003409:Congenital Hypothyroidism; D004594:Electrophysiology; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000503:physiopathology; D007037:Hypothyroidism / Q000188:drug therapy; D007231:Infant, Newborn; D008297:Male; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000503:physiopathology*; D011446:Prospective Studies; D012018:Reflex; D013497:Sural Nerve / Q000503:physiopathology
vernacular_title: L'exploration neuro-physiologique des nerfs périphériques des nouveaunés porteurs d'une hypothyroïdie congénitale. Intérêt dans la surveillance du traitement substitutif.