Specific motor effects of capsaicin on human jejunum.
Capsaicin (1 microM) produced a biphasic effect on the motility of longitudinal muscle strips from human jejunum e.g. an initial inhibitory effect on nerve-mediated contractions followed by a delayed increase in motility. Neither effect was observed upon a second application of the drug, indicating desensitization, a proposed marker of the action of capsaicin on sensory nerves. Both substance P and neurokinin A produced a contraction of isolated human jejunum, while calcitonin gene-related peptide had a small and inconsistent inhibitory effect.
Maggi
C A
CA
Pharmacology Department, Menarini Pharmaceuticals, Florence, Italy.
Patacchini
R
R
Santicioli
P
P
Giuliani
S
S
Turini
D
D
Barbanti
G
G
Beneforti
P
P
Misuri
D
D
Meli
A
A
D000328:Adult; D000368:Aged; D002211:Capsaicin / Q000494:pharmacology*; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007583:Jejunum / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*
D002211:Capsaicin