A preliminary note on inhibiting effect of alpha-tocopherol (vit. E) on protein glycation.
Human plasma albumin was incubated in 25 mM/l glucose at 37 degrees C for up to sevent days. Aliquots of this mixture were also incubated with alpha-tocopherol (Vitamin E) at 2 mg/dl, 4 mg/dl and 8 mg/dl, respectively. Vitamin E inhibited protein glycation and, furthermore, shows a dose-dependent effect. This report suggests the possibility of using Vitamin E, at therapeutic doses, to obtain the inhibition of non-enzymatic glycation.
Ceriello
A
A
Cattedra di Diabetologia e Dietoterapia, I Facoltà di Medicina, Università di Napoli, Italy.
Giugliano
D
D
Quatraro
A
A
Dello Russo
P
P
Torella
R
R
D001786:Blood Glucose / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology; D017127:Glycation End Products, Advanced; D006031:Glycosylation; D006801:Humans; D007700:Kinetics; D012709:Serum Albumin / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology*; D000093423:Glycated Serum Albumin
D001786:Blood Glucose; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D014810:Vitamin E; D000431:Ethanol; D000093423:Glycated Serum Albumin