title: Collagen biosynthesis in a case of infantile myofibromatosis.
abstract: Cells from a skin nodule from a patient with a recurrent form of familial myofibromatosis were cultivated in vitro. A metabolic study showed that these cells behaved like fibroblasts with collagen synthesis, a normal percentage of type III collagen, hydroxylation rate and the ability to contract a collagen gel. The main disturbances were the decreased synthesis and increased cell multiplication rate after a lag phase. This behavior was compared with that of a fibroblast culture from normal skin.
authors.affiliation: Laboratory of Biochemistry, Medical School, Saint-Etienne, France.
authors.forename: A
authors.initials: A
authors.lastname: Chamson
authors.forename: J
authors.initials: J
authors.lastname: Frey
authors.forename: D
authors.initials: D
authors.lastname: Frappaz
authors.forename: G
authors.initials: G
authors.lastname: Damon
authors.forename: F
authors.initials: F
authors.lastname: Freycon
authors.forename: B
authors.initials: B
authors.lastname: Lauras
mesh_terms: D003094:Collagen / Q000096:biosynthesis*; D004273:DNA, Neoplasm / Q000032:analysis; D005350:Fibroma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007223:Infant; D007700:Kinetics; D007889:Leiomyoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis / Q000096:biosynthesis; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014407:Tumor Cells, Cultured
chemical_list: D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D003094:Collagen