[Effect of dimephosphon on the inflammatory reaction].
The effect of dimephosphon on the development of the experimental inflammatory edema (agar-, dextran- and carrageenan-induced edema) of rat and mouse paws was compared with those of voltaren and dimedrol. The anti-inflammatory activity of dimephosphon occurring on account of the antiexudative component was established. The antihistamine and antiserotonin activity of dimephosphon was shown on models of paw edema caused by subplantar administration of mediators and modulators of inflammation. The drug exerts no influence on similar effects of bradykinin and prostaglandin E2, intensifies edema-inducing action of prostaglandin F2 alpha. The involvement of the anti-inflammatory component in the therapeutic effect of dimephosphon is suggested.
Ziganshina
L E
LE
Studentsova
I A
IA
Zaikonnikova
I V
IV
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use; D004155:Diphenhydramine / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D009943:Organophosphorus Compounds; C049638:dimephosphon; D004008:Diclofenac; D004155:Diphenhydramine
Vliianie dimefosfona na vospalitel'nuiu reaktsiiu.