Functional and structural implications of variable region immunoglobulin dynamic states.
The consequence of multiple conformational states in the immunoglobulin variable region are considered. Bound ligand is viewed as a stabilizer of one conformer from a series of non-liganded conformers. Kinetic, equilibrium, thermodynamic and crystal formation information are used as supporting evidence for a unique conformer which is the crystallizable liganded state. The multi-state model is discussed in terms of certain biological and biochemical properties exhibited by the immunoglobulin molecule.
Voss
E W
EW
Department of Microbiology, School of Life Sciences, University of Illinois, Urbana 61801.
Dombrink-Kurtzman
M A
MA
Miklasz
S D
SD
D000937:Antigen-Antibody Reactions; D001666:Binding Sites, Antibody; D007140:Immunoglobulin Fab Fragments; D007135:Immunoglobulin Variable Region; D007700:Kinetics; D009038:Motion; D011487:Protein Conformation
D007140:Immunoglobulin Fab Fragments; D007135:Immunoglobulin Variable Region