The influence of ethanol on pharmacokinetic parameters of procainamide in rabbits.
The effect of ethanol on procainamide pharmacokinetics was investigated in rabbits. Procainamide was injected iv in a dose of 13 mg.kg-1 together with ethanol in doses of 0.1, 0.5 or 1.0 g.kg-1.h-1. In another experiment procainamide was given in a dose of 40 mg.kg-1 together with ethanol in a dose of 1.0 g.kg-1 p.o. The third group of rabbits received procainamide in the form of 1 tablet 0.25 g together with ethanol in a dose of 1.0 g.kg-1 p.o. Ethanol shortened biological half-life of procainamide elimination, increased the value of the rate constant of elimination and procainamide clearance. Concomitant oral administration of ethanol and procainamide decreased the peak plasma concentration and decreased the area under the drug level curve.
Orszulak-Michalak
D
D
Department of Pharmacodynamics, Medical Academy Lódź, Poland.
Polakowski
P
P
D000284:Administration, Oral; D000818:Animals; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D007275:Injections, Intravenous; D011342:Procainamide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D013607:Tablets
D013607:Tablets; D000431:Ethanol; D011342:Procainamide