Translocation t(11;21)(q24;q11.2) is a new nonrandomly occurring chromosome change in myelodysplastic syndromes.
An identical translocation, t(11;21)(q24;q11.2), has been observed in three patients with a myelodysplastic syndrome. In all cases, duplication of the 11q+ marker and loss of the normal chromosome 11 were observed either at diagnosis or during the evolution of the disease. This apparently characteristic chromosome abnormality has not been previously described.
Rege-Cambrin
G
G
Dipartimento di Scienze biomediche e Oncologia Umana, University of Torino, Italy.
Mecucci
C
C
Kerim
S
S
Scaravaglio
P
P
Boogaerts
M
M
Van den Berghe
H
H
D001853:Bone Marrow / Q000473:pathology; D002478:Cells, Cultured; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D002891:Chromosomes, Human, Pair 21; D006801:Humans; D007621:Karyotyping; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D014178:Translocation, Genetic