title: Genetic studies of human apolipoproteins. III. Polymorphism of apolipoprotein C-II.
abstract: Using a simple and rapid one-dimensional isoelectric focusing technique followed by immunoblotting, we have detected genetic polymorphism of human apolipoprotein C-II (APO C-II) in normal unfractionated plasma samples of individuals of black ancestry. Two common autosomal codominantly expressed alleles, designated APO C-II*1 and APO C-II*2, at the APO C-II structural locus have been observed with frequencies of 0.975 and 0.025 in US blacks and 0.943 and 0.049 in Nigerian blacks. In addition, the gene product of a rare allele designated APO C-II*3 was observed in a single Nigerian black. Apart from a single example of an APO C-II 2-1 phenotype in plasma samples from 187 whites, which was electrophoretically identical to the 2-1 phenotype observed in blacks, it appears that APO C-II*2 is a unique black marker of potential importance in anthropogenetic and atherosclerosis studies.
authors.affiliation: Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pa.
authors.forename: B
authors.initials: B
authors.lastname: Sepehrnia
authors.forename: M I
authors.initials: MI
authors.lastname: Kamboh
authors.forename: R E
authors.initials: RE
authors.lastname: Ferrell
mesh_terms: D000483:Alleles; D053304:Apolipoprotein C-II; D001056:Apolipoproteins C / Q000097:blood / Q000235:genetics*; D044383:Black People; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007120:Immunochemistry; D007525:Isoelectric Focusing; D009549:Nigeria; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D053304:Apolipoprotein C-II; D001056:Apolipoproteins C