Acute fulminating fatal leukoencephalopathy as the only manifestation of human immunodeficiency virus infection.
A case of acute human immunodeficiency virus (HIV) infection manifested by a rapidly fulminating, necrotizing, demyelinating encephalopathy that led to brain death in 5 days is reported. Autopsy demonstrated predominant white matter lesions, acute neuronal damage, and scanty cellular response. Cultures of cerebrospinal fluid were positive for HIV, suggesting an acute infection.
Jones
H R
HR
Department of Neurology, Lahey Clinic Medical Center, Burlington, MA 01805.
Ho
D D
DD
Forgacs
P
P
Adelman
L S
LS
Silverman
M L
ML
Baker
R A
RA
Locuratolo
P
P
D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid / Q000150:complications* / Q000401:mortality; D000328:Adult; D005260:Female; D006678:HIV / Q000302:isolation & purification; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000000981:diagnostic imaging / Q000209:etiology* / Q000382:microbiology / Q000401:mortality; D011859:Radiography