[Dynamics of the renal excretion of glycosaminoglycans as affected by thyroid therapy of hypothyroidism].
The state of renal excretion of glycosaminoglycans (GAG) was investigated in 15 patients with hypothyrosis of various degree of gravity before and during thyroid therapy. A raised level of GAG excretion with urine reflecting excessive GAG tissue accumulation was revealed. A degree of elevation was unrelated to a gravity of disease and grew with a period of disease. Thyroid therapy considerably increased GAG renal excretion, particularly in patients with a longer period of disease. A GAG level in daily urine can be used as an additional diagnostic criterion in hypothyrosis and the time course of GAG can serve for assessment of therapeutic efficacy.
Nazarov
A N
AN
Egart
F M
FM
Bobrovskaia
T A
TA
Daĭkhin
E I
EI
Sugoniaeva
V T
VT
D000328:Adult; D002908:Chronic Disease; D004338:Drug Combinations; D005260:Female; D006025:Glycosaminoglycans / Q000652:urine*; D006728:Hormones / Q000008:administration & dosage*; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000652:urine*; D008297:Male; D008875:Middle Aged; D013607:Tablets; D013963:Thyroid Hormones / Q000008:administration & dosage*; D013997:Time Factors
D004338:Drug Combinations; D006025:Glycosaminoglycans; D006728:Hormones; D013607:Tablets; D013963:Thyroid Hormones
Dinamika pochechnoĭ ékskretsii glikozaminoglikanov pod vliianiem tireoidnoĭ terapii pri gipotireoze.