title: Predictive value of flow cytometric DNA-analysis on fresh retinoblastoma tissue.
abstract: The cellular DNA content and the distribution of tumour cells in different phases of the cell cycles has been analysed in 8 consecutive enucleated eyes with retinoblastoma. All tumours had abnormal ploidy levels. The analysis did not reveal any specific pattern in 2 tumours which had metastasized compared to 6 local tumours. The flow cytometric analysis alone or in combination with histopathology appeared not to improve the classification of large retinoblastomas.
authors.affiliation: Department of Ophthalmology, Arhus University Hospital, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Winther
authors.forename: N
authors.initials: N
authors.lastname: Ehlers
authors.forename: O A
authors.initials: OA
authors.lastname: Jensen
authors.forename: J
authors.initials: J
authors.lastname: Overgaard
authors.forename: J U
authors.initials: JU
authors.lastname: Prause
mesh_terms: D002675:Child, Preschool; D004273:DNA, Neoplasm / Q000032:analysis* / Q000235:genetics; D005134:Eye Neoplasms / Q000032:analysis* / Q000235:genetics; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D011003:Ploidies; D011379:Prognosis; D012175:Retinoblastoma / Q000032:analysis* / Q000235:genetics
chemical_list: D004273:DNA, Neoplasm