title: Probucol enhances cholesterol efflux from cultured human skin fibroblasts.
abstract: To explore whether the reported xanthoma-reducing effects of probucol are related to tissue-specific mechanisms of the drug, the influence of probucol on cholesterol efflux from cultured human skin fibroblasts was investigated. Incubation of cells with probucol led to a 2-fold enhancement of high-density lipoprotein-mediated cholesterol efflux. This result raises the possibility that probucol may reduce cholesterol accumulation in tissues through a cholesterol-mobilizing action.
authors.affiliation: Division of Endocrinology, University of Miami School of Medicine, Florida.
authors.forename: R B
authors.initials: RB
authors.lastname: Goldberg
authors.forename: A
authors.initials: A
authors.lastname: Mendez
mesh_terms: D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D011341:Probucol / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism
chemical_list: D008074:Lipoproteins; D010636:Phenols; D002784:Cholesterol; D011341:Probucol