title: Translocation t(3;4)(q26;q21) in myelodysplastic syndrome with megakaryoblastic proliferation.
abstract: A 74-year-old Japanese male with a 4-year history of refractory anemia with excess of blasts is reported here. Chromosome study revealed the bone marrow cells of this patient to contain a t(3;4)(q26;q21). Ultrastructural analysis of platelet peroxidase and immunocytochemical study using monoclonal antibody for platelet antigen revealed a large number of blasts in the bone marrow to be megakaryoblasts. Thus, this case was thought to be one of a myelodysplastic syndrome with excess of blasts including megakaryoblastic proliferation showing chromosome changes at 3q26 and 4q21. The relationship of the anomaly on the long arm of a chromosome #3, especially at band 3q26, to abnormal megakaryoblastic proliferation is discussed.
authors.affiliation: Department of Internal Medicine, Tokyo Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohyashiki
authors.forename: Y
authors.initials: Y
authors.lastname: Enomoto
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Nehashi
authors.forename: J H
authors.initials: JH
authors.lastname: Ohyashiki
authors.forename: K
authors.initials: K
authors.lastname: Toyama
mesh_terms: D000368:Aged; D001792:Blood Platelets / Q000201:enzymology; D001853:Bone Marrow / Q000473:pathology; D002455:Cell Division; D002871:Chromosome Banding; D002893:Chromosomes, Human, Pair 3; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D007621:Karyotyping; D008297:Male; D008533:Megakaryocytes / Q000166:cytology*; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000235:genetics* / Q000473:pathology; D010544:Peroxidases / Q000097:blood; D014178:Translocation, Genetic
chemical_list: D010544:Peroxidases