title: [Effect of the calcium antagonist nifedipine on central and peripheral hemodynamics in patients with primary pulmonary hypertension].
abstract: 15 patients with primary pulmonary hypertension (PPH) were studied. An acute test with 20 mg nifedipine (N) sublingually was performed and the pulmonary artery pressure (PAP) was measured. N had manifest arterolodilating effect in the systemic and especially pulmonary circulation, induced decrease in the total peripheral and total pulmonary vascular resistance (TPerVR and TPulVR) by 21.7 and 25.3%, correspondingly. N had principal effect on pulmonary arterioles (TPerVR/TPulVR ratio increased by 16.9%). Systolic and diastolic PAP decreased in this case by 15.2 and 18.4%, correspondingly. All the patients demonstrated increase in cardiac output (on the average by 17.0%) and insignificant increase in heart rate (7.4%).
authors.forename: A
authors.initials: A
authors.lastname: Khosseĭn
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Mareev
authors.forename: F T
authors.initials: FT
authors.lastname: Ageev
authors.forename: L N
authors.initials: LN
authors.lastname: Sazonova
authors.forename: N M
authors.initials: NM
authors.lastname: Lobova
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use*; D011651:Pulmonary Artery / Q000503:physiopathology; D011652:Pulmonary Circulation / Q000187:drug effects*; D014665:Vasodilator Agents
chemical_list: D014665:Vasodilator Agents; D009543:Nifedipine
vernacular_title: Vliianie kal'tsevogo antagonista nifedipina na tsentral'nuiu i perifericheskuiu gemodinamiku u bol'nykh pervichnoĭ legochnoĭ gipertonieĭ.