title: Kallikrein release from the kidney: in vitro effects of AVP and DDAVP in three species.
abstract: Kallikrein released during superfusion of rat, monkey and human kidney cortical slices was mainly in the inactive form. Arginine vasopressin and the nonpressor synthetic analogue des-amino-D-arginine vasopressin increased the release of inactive kallikrein to a similar extent in all species. No detectable change in active kallikrein release occurred. These results suggest a role for the kallikrein-kinin system in the regulation of the hydro-osmotic effect of arginine vasopressin.
authors.affiliation: Department of Renal and Metabolic Medicine, St. Mary's Hospital, Portsmouth, U.K.
authors.forename: S J
authors.initials: SJ
authors.lastname: Grenfell
authors.forename: J D
authors.initials: JD
authors.lastname: Albano
authors.forename: D G
authors.initials: DG
authors.lastname: Waller
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007610:Kallikreins / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008252:Macaca fascicularis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001127:Arginine Vasopressin; D007610:Kallikreins; D003894:Deamino Arginine Vasopressin