title: Influence of the hypothalamic-pituitary axis on the androgen regulation of the ocular secretory immune system.
abstract: The purpose of the present investigation was to examine the influence of the hypothalamic-pituitary axis on the androgen regulation of the ocular secretory immune system. Studies included the following experiments: (1) Testosterone administration significantly increased the immunoglobulin A (IgA) and free secretory component (SC) levels in tears of adult, orchiectomized and sham-hypophysectomized rats, as compared with those in tears of saline-treated controls. (2) Hypophysectomy completely inhibited this androgen effect. (3) Transfer of the pituitary to under the kidney capsule in orchiectomized and hypophysectomized rats did not restore the physiological conditions required for testosterone's stimulation of tear IgA and SC. (4) Selective ablation of the anterior pituitary gland also interfered with the testosterone-induced elevation of tear IgA and SC content. (5) Treatment of orchiectomized and/or hypophysectomized rats with rat prolactin, growth hormone, alpha-melanocyte-stimulating hormone or vehicle for 4 days had no effect on tear SC and/or IgA levels. Overall, these findings demonstrate that an intact hypothalamic-pituitary axis either supports or mediates the androgen control of the secretory immune system in the eye.
authors.affiliation: Department of Ophthalmology, Harvard Medical School, Boston, MA 02114.
authors.forename: D A
authors.initials: DA
authors.lastname: Sullivan
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000494:pharmacology; D007016:Hypophysectomy; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D007128:Immunoglobulin Fragments / Q000032:analysis*; D008297:Male; D009919:Orchiectomy; D010902:Pituitary Gland / Q000637:transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012635:Secretory Component / Q000032:analysis*; D013666:Tears / Q000187:drug effects / Q000276:immunology*; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D007071:Immunoglobulin A, Secretory; D007128:Immunoglobulin Fragments; D012635:Secretory Component; D013739:Testosterone; D002784:Cholesterol