Bands involved in primary chromosome rearrangements in sarcomas are not constitutionally liable to breakage in sarcoma patients.
The localization of breakpoints in spontaneous chromosome aberrations, i.e., chromatid and chromosome gaps, breaks, and exchanges, has been studied in cultured skin fibroblasts from 34 untreated patients with musculoskeletal sarcoma and 38 controls. A total of 325 aberrations in the sarcoma group and 251 in the control group could be assigned to particular bands. The distribution was non-random (P less than 0.001) in both groups. Twenty-one bands in the sarcoma group and 20 in the control group appeared as hot spots, with 11 represented in both groups. Only three hot spots, all of which were present among both patients and controls, coincided with bands involved in primary sarcoma-associated chromosome rearrangements. The results indicate that the chromosome breakage pattern of non-malignant cells is similar in sarcoma patients and controls. Hence, the occurrence of primary structural rearrangements in sarcomas cannot be accounted for by any constitutional proneness to chromosome breakage at these bands.
Mertens
F
F
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Johansson
B
B
Heim
S
S
Mandahl
N
N
Rydholm
A
A
Mitelman
F
F
D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D006801:Humans; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000235:genetics*; D012867:Skin; D014178:Translocation, Genetic