title: Heterogeneity of pepsinogens in the urine of children.
abstract: The existence of a significant linear relationship between the concentration of chlorides and the activity of pepsinogen (PG) in the urine was ascertained in the case of full-term infants 3 days to 6 weeks of age. At the age of 4-6 weeks, a significant relationship was found between the urinary pepsinogen activity and the urinary creatinine concentration, and between the urinary pepsinogen activity in the urine and the urine osmolality. Immediately after birth, the Pg7 fraction of PG II in the urine was found in all cases and, at the age of 4-6 weeks, in 11% of cases. In regard to the time factor, the conspicuous drop in the occurrence of the Pg7 fraction corresponds to the new qualitative relationship between the pepsinogen activity in the urine and the creatinine concentration in the urine and between the former and the urine osmolality. In premature infants, the Pg7 fraction disappears more slowly. The spectrum of pepsinogens in the urine was examined in children suffering from various diseases. In a girl with lymphoma, we found the Pg7 fraction, but this finding was temporary only.
authors.affiliation: First Pediatric Clinic, Faculty of Pediatrics, Charles University, Prague, Czechoslovakia.
authors.forename: J
authors.initials: J
authors.lastname: Nevoral
authors.forename: H
authors.initials: H
authors.lastname: Tomásová
authors.forename: J
authors.initials: J
authors.lastname: Srajer
mesh_terms: D000375:Aging / Q000378:metabolism; D002712:Chlorides / Q000652:urine; D003404:Creatinine / Q000652:urine; D003550:Cystic Fibrosis / Q000652:urine; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000652:urine; D007236:Infant, Small for Gestational Age / Q000652:urine; D008286:Malabsorption Syndromes / Q000652:urine; D009369:Neoplasms / Q000652:urine; D009994:Osmolar Concentration; D010435:Pepsinogens / Q000652:urine*
chemical_list: D002712:Chlorides; D010435:Pepsinogens; D003404:Creatinine