Behavioral changes in rats on the day after acute ethanol intoxication.
Activity in computer-monitored running wheels, behavior in open-field tests, body temperature measured by rectal probe, and vocalization were examined in rats after a single injection of 2.5 g/kg ethanol or saline. A reduction in running-wheel activity occurred during intoxication, followed by a significant increase in running 20-24 hr after the injection. Also 24 hr after ethanol, among rats kept in normal cages, there was an increase in body temperature and vocalization and a decrease in ambulation in a dark, quiet open field. Each of these 3 aftereffects was reduced or abolished in the rats with access to a running wheel. The results confirm and extend previous findings of aftereffects of acute intoxication in rats with a time course similar to hangover in humans.
Research Laboratories of the Finnish Alcohol Company (Alko Ltd), Helsinki.
J D
JD
Sinclair
K
K
Gustafsson
D000435:Alcoholic Intoxication / Q000503:physiopathology / Q000523:psychology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects*; D004195:Disease Models, Animal; D000431:Ethanol / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D005082:Physical Exertion / Q000187:drug effects*; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000523:psychology; D014828:Vocalization, Animal / Q000187:drug effects*
D000431:Ethanol