Prediction of X-ray induced mitotic delay and recovery of G2 cells.
A mathematical model is presented that predicts the delay of mitosis caused by X-irradiation of an asynchronous, exponentially growing cell culture (data of Schneiderman & Schneiderman, 1984). In the model, based on Gompertz kinetics, the driving function to generate the curves is a simple exponential decay expression. For the delayed mitotic progress curves, this function characterizes the distribution of the time required for cells to enter mitosis.
Department of Biological Science, Florida State University, Tallahassee 32306.
D M
DM
Easton
M H
MH
Schneiderman
D002478:Cells, Cultured; D007399:Interphase; D007700:Kinetics; D008433:Mathematics; D008938:Mitosis / Q000528:radiation effects*; D008954:Models, Biological