Importance of the antioxidative potential for free radical induced heart damage.
It is demonstrated on the heart tissue of rats that the extent of lipid peroxidation following induction of radical-forming mechanisms is correlated with the Vit. E concentration of the heart. When incubated with Fe2+/Vit.C, the heart tissue of normotensive (WKY) and hypertensive rats receiving Vit. E supplementation (SHR + Vit. E), consistently with their higher Vit. E concentration, reacted with a lower lipid peroxidation than the heart tissue of SHR. Considering the importance of lipid peroxidation as a damaging mechanism at ischemia, the lower Vit. E concentration in the hearts of SHR should be responsible for the lower tolerance to ischemia in comparison to WKY.
Schimke
I
I
Inst. Pathol. Clin. Biochem., Humboldt-Univ., Berlin, GDR.
Schimke
E
E
Papies
B
B
Moritz
V
V
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D003327:Coronary Disease / Q000378:metabolism*; D005609:Free Radicals; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D014810:Vitamin E / Q000378:metabolism* / Q000494:pharmacology
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D014810:Vitamin E; D010100:Oxygen