Activity of amikacin against Mycobacterium avium complex under simulated in vivo conditions.
We studied the activity of amikacin against Mycobacterium avium complex strain 101 by using continuous-level, changing concentrations which simulated levels in serum in a patient, and pulsed exposures. Amikacin at a concentration of 5 or 15 micrograms/ml showed rapid bactericidal action following constant exposure of the organisms. With the in vitro model, using a peak concentration of 10 or 20 micrograms/ml, complete sterilization was obtained by day 7. In pulsed-exposure studies, a minimum period of contact of 72 or 96 h at a concentration of 10 micrograms/ml was needed for complete sterilization.
National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.
P R
PR
Gangadharam
L
L
Kesavalu
P N
PN
Rao
V K
VK
Perumal
M D
MD
Iseman
D000583:Amikacin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects*
D000583:Amikacin