An alternative protocol for the medical management of canine pituitary-dependent hyperadrenocorticism.
As an alternative to the o,p'-DDD treatment aimed at the selective destruction of the adrenal cortices, the authors have introduced a protocol aimed at the complete destruction of the adrenal cortices. It consists of a longer period of daily treatment with o,p'-DDD and lifelong substitution for primary hypoadrenocorticism. The results obtained in 41 dogs, with a minimum follow-up period of one year, indicate that this approach has advantages over lifelong maintenance therapy with o,p'-DDD.
Rijnberk
A
A
Small Animal Clinic, Faculty of Veterinary Medicine, State University of Utrecht, The Netherlands.
Belshaw
B E
BE
D000302:Adrenal Cortex / Q000187:drug effects*; D000308:Adrenocortical Hyperfunction / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D003348:Cortisone / Q000031:analogs & derivatives / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D005438:Fludrocortisone / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008939:Mitotane / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D012965:Sodium Chloride / Q000627:therapeutic use
D012965:Sodium Chloride; D008939:Mitotane; D005438:Fludrocortisone; D003348:Cortisone; C034635:fludrocortisone acetate