Neuron numbers in Alzheimer's disease: cell-specific pathology.
The significance of the particular neurons lost in Alzheimer's disease is discussed in the context of their likely anatomic role as projection neurons. The location and function of affected neurons is emphasized, rather than absolute number.
Hyman
B T
BT
Department of Neurology, University of Iowa College of Medicine, Iowa City 52242.
Van Hoesen
G W
GW
D000368:Aged; D000375:Aging / Q000473:pathology; D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002452:Cell Count; D006801:Humans; D008568:Memory / Q000502:physiology; D009474:Neurons / Q000473:pathology*