Increase in copy number of N-myc in retinoblastomas in comparison with chromosome abnormality.
N-myc oncogene amplification was studied in tumor tissue DNA from Japanese retinoblastoma patients, taking into consideration their uni- or bilateral disease form, their family history, and any chromosome abnormalities. Of the 23 cases examined, seven (30%) showed a 1.9- to 2.3-fold amplification of N-myc. No correlation was found between N-myc amplification and either tumor form or family history. Two of three cases having double minute bodies in their tumors showed N-myc amplification. In two tumors with 13q deletions, one produced in the host with constitutional 13q--abnormality showed no N-myc amplification, and the other one produced in the host with normal karyotype showed an N-myc amplification. These results indicate N-myc amplification is independent of the known genetic background in retinoblastoma patients.
Department of Radiation Oncology, Faculty of Medicine, University of Tokyo, Japan.
K
K
Sakai
H
H
Tanooka
M S
MS
Sasaki
Y
Y
Ejima
A
A
Kaneko
D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D005134:Eye Neoplasms / Q000235:genetics*; D005784:Gene Amplification; D005819:Genetic Markers; D006801:Humans; D007223:Infant; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D012175:Retinoblastoma / Q000235:genetics*
D005819:Genetic Markers