Hypothalamo-hypophyseal-gonadal function in the rat following administration of the novel and selective D-1 agonist CY 208-243.
The effects of the novel and selective dopamine D-1 agonist CY 208-243 on the rat hypothalamo-hypophyseal-gonadal (HHG) axis were studied. CY 208-243 did not modify the concentration of luteinizing hormone (LH) in serum from female or male rats, and had no effect upon opiate antagonist-induced stimulation of LH secretion in male rats. CY 208-243 did not inhibit ovulation in cycling female rats. Thus, D-1 receptor activation by systemic drug administration does not alter HHG function in rats.
Siegel
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RA
Preclinical Research, Pharma Division, Sandoz AG, Basel, Switzerland.
Markó
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M
D000818:Animals; D018492:Dopamine Antagonists; D005260:Female; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D007211:Indoles / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009271:Naltrexone / Q000494:pharmacology; D010060:Ovulation / Q000187:drug effects; D010617:Phenanthridines / Q000494:pharmacology*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*
D018492:Dopamine Antagonists; D007211:Indoles; D010617:Phenanthridines; D011954:Receptors, Dopamine; C054531:CY 208-243; D009271:Naltrexone; D007986:Luteinizing Hormone