[Adrenal cortical function, immunological reactivity and the blood serum cholesterol level of esophageal cancer patients].
Functional status of the adrenal cortex was studied in 80 patients (aged 31-70) suffering esophageal cancer (predominantly stage III). Blood serum showed high levels of cortisol and 11-HCS and a decrease in those of 17-HCS and 17-KS. Groups with hypo-, normo- and hypercholesterolemia were formed. Lowered blood-cholesterol levels were more frequent in cancer patients as compared to healthy subjects. Cases under study revealed decreased immunologic vigor. A peak concentration of cortisol was matched by a decrease in E-RFC level and a sharp drop in that of blood serum cholesterol. Combined chemoradiation treatment partially brought glucocorticoid and 17-KS levels to normal but did not affect cell-mediated immunity. Complex immunocorrection and chemoradiation treatment normalized hormonal function and immunologic indexes.
Khan
O G
OG
Baisheva
S A
SA
Togaĭbaeva
Z I
ZI
Sysoeva
M I
MI
D015062:11-Hydroxycorticosteroids / Q000097:blood; D015065:17-Hydroxycorticosteroids / Q000652:urine; D015068:17-Ketosteroids / Q000652:urine; D000302:Adrenal Cortex / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000097:blood / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation
D015062:11-Hydroxycorticosteroids; D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D002784:Cholesterol; D006854:Hydrocortisone
Funktsiia kory nadpochechnikov, immunologicheskaia reaktivnost' i uroven' kholesterina syvorotki krovi u bol'nykh rakom pishchevoda.