A single neonatal treatment with methylcholanthrene or benzo(a)pyrene alters microsomal enzyme activity for life.
A single neonatal exposure to methylcholanthrene or benzo(a)-pyrene altered the hepatic microsomal enzyme activity of rats for a long time. Methylcholanthrene depressed, whereas benzo(a)pyrene enhanced the activity of the microsomal enzyme system. The former had a greater influence on males than on females, whereas the latter acted practically uniformly on both sexes.
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
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Csaba
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Dobozy
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Szeberényi
D000818:Animals; D000831:Animals, Newborn; D001564:Benzo(a)pyrene / Q000494:pharmacology*; D005260:Female; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D013997:Time Factors
D001564:Benzo(a)pyrene; D008748:Methylcholanthrene