Total sleep deprivation and Parkinson disease.
Twelve Parkinson disease (PD) patients were submitted to a single night of total sleep deprivation (SD). Disease duration had a median of 5.1 years and all were using either anticholinergic or L-Dopa or the combination of both drugs. After SD there was an improvement of rigidity, bradykinesia, gait and posture disturbances and functional disability that remained significant for 2 weeks. No effect was observed on tremor. Concerning depressive symptoms, a significant difference was noted, that remained for one week. These results suggest that SD may be an useful procedure to improve PD symptomatology. It is discussed a possible change of dopaminergic receptors, induced by SD, to explain the improvement.
Department of Neurology and Neurosurgery, Escola Paulista de Medicina, São Paulo, Brazil.
P H
PH
Bertolucci
L A
LA
Andrade
J G
JG
Lima
E A
EA
Carlini
D000328:Adult; D000368:Aged; D003863:Depression / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D009069:Movement Disorders / Q000628:therapy*; D010300:Parkinson Disease / Q000628:therapy*; D011569:Psychiatric Status Rating Scales; D011954:Receptors, Dopamine / Q000502:physiology; D012892:Sleep Deprivation; D012895:Sleep, REM
D011954:Receptors, Dopamine