Survival of red cells stored for 21 and 35 days in a non-di-(2-ethylhexyl)phthalate plastic container.
Whole blood and red cells were stored using citrate-phosphate-dextrose (CPD) and citrate-phosphate-dextrose-adenine (CPDA-1) anticoagulants in polyvinylchloride bags made flexible with di-(2-ethylhexyl)phthalate (DEHP) or tri-(2-ethylhexyl)trimellitate (TOTM) plasticizers. After storage the posttransfusion viability of these cells was tested in autologous donors. Cells stored in TOTM-plasticized film had a survival rate less than 75% when stored for 35 days, while other systems had a survival greater than this. When compared with the red cells stored in CPD-DEHP-plasticized film, the viability of whole blood and red cells stored in CPDA-TOTM showed a statistically significant decrease (p = less than 0.01). Therefore, red cell storage in TOTM-plasticized PVC with current anticoagulant should be limited to 21 days.
Department of Pathology, Los Angeles County Harbor-UCLA Medical Center, Torrance.
B A
BA
Myhre
D
D
Johnson
C S
CS
Marcus
S
S
Demaniew
R
R
Carmen
E
E
Nelson
D001565:Benzoates / Q000009:adverse effects*; D001793:Blood Preservation; D004051:Diethylhexyl Phthalate; D004905:Erythrocyte Aging; D004912:Erythrocytes; D006801:Humans; D010795:Phthalic Acids; D010968:Plasticizers / Q000009:adverse effects*
D001565:Benzoates; D010795:Phthalic Acids; D010968:Plasticizers; C036101:tri-(2-ethylhexyl)trimellitate; D004051:Diethylhexyl Phthalate