Prevalence of cardiac conduction disturbances during carbamazepine treatment: preliminary data.
Twenty-five epileptic patients chronically treated with carbamazepine underwent 24 h electrocardiogram (ECG) monitoring in order to evaluate the prevalence of cardiac conduction abnormalities. Plasma levels of carbamazepine and its metabolite, carbamazepine-10,11-epoxide, were determined by liquid chromatography. Six patients had mild ECG abnormalities. These patients did not differ from the others with respect to plasma concentrations of the drug and its metabolite.
Spina
E
E
Department of Clinical Pharmacology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Kenneback
G
G
Bergfeldt
L
L
Tomson
T
T
D000328:Adult; D000368:Aged; D002220:Carbamazepine / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000097:blood / Q000627:therapeutic use; D004562:Electrocardiography; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration
D002220:Carbamazepine; C012227:carbamazepine epoxide