Cysteamine protects against diarrhoea induced by castor oil. This protective effect can be potentiated by SH-alkylator treatment.
Cysteamine given orally or subcutaneously protects against diarrhoea induced by castor oil. Pretreatment with N-EM, an SH-alkylator, does not influence the occurrence of diarrhoea. Furthermore, N-EM pretreatment does not influence the protective effect of loperamide or difenoxilate. However, N-EM pretreatment potentiates the protective effects of cysteamine or indomethacin against diarrhoea. These findings indicate that sulfhydryl-sensitive processes may also be involved in the mechanisms of diarrhoea.
Pharmacological Research Centre, Chemical Works of Gedeon Richter, Ltd., Budapest, Hungary.
E
E
Ezer
T
T
Wagner
D000477:Alkylating Agents / Q000627:therapeutic use*; D000818:Animals; D002368:Castor Oil / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003543:Cysteamine / Q000627:therapeutic use*; D003967:Diarrhea / Q000139:chemically induced / Q000517:prevention & control*; D004357:Drug Synergism; D005033:Ethylmaleimide / Q000627:therapeutic use*; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000627:therapeutic use*
D000477:Alkylating Agents; D013438:Sulfhydryl Compounds; D003543:Cysteamine; D002368:Castor Oil; D005033:Ethylmaleimide