Increased alcohol intake induced by chronic stimulants: is "orality" involved?
One should be able to mimic aspects of chronic stress using pharmacological stimulants administered continuously. Alcohol preference can be selectively increased by the continuous administration of two stimulants: D-amphetamine (which works well), and nicotine (which is extremely potent). This effect does not occur with continuous administration of a variety of other psychoactive compounds such as hallucinogens and tranquilizers, nor does it occur if stimulants are administered chronically but in an intermittent fashion. In order to obtain this effect, access to the alcohol must be withheld until an initial period of anorexia passes and a period of heightened orality develops. This heightened fluid intake effect appears to be selective for alcohol consumption, for it does not occur for other sources of calories or other novel tastes.
Ellison
G
G
Dept. of Psychology, UCLA.
Potthoff
A
A
D000428:Alcohol Drinking / Q000187:drug effects*; D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D006801:Humans; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D013649:Taste
D009538:Nicotine; D003975:Diazepam; D003913:Dextroamphetamine