[Pharmacokinetics of prednisolone administered to cows in the form of a prednisolone acetate solution in dimethyl sulfoxide in association with antibiotics].
Pharmacokinetic parameters of prednisolone after intramuscular administration of prednisolone acetate as a solution were determined in cattle. Analysis of absorption revealed that a first fraction of the dose (about 20%) was rapidly absorbed with an half time of absorption of 1.76 +/- 0.725 h; the second fraction (about 80% of the dose) was absorbed more slowly with an half time of absorption of 12.3 +/- 3.16 h. Such a process of absorption was different of that described for prednisolone acetate suspension for which rate of absorption was slower. Therapeutic consequences of these kinetic differences were discussed for the use of fixed combination of antibiotics and corticosteroid.
Station de Pharmacologie-Toxicologie, INRA, Toulouse.
M
M
Oukessou
M
M
Alvinerie
P L
PL
Toutain
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002417:Cattle / Q000378:metabolism*; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage; D004338:Drug Combinations; D005260:Female; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; C009935:prednisolone acetate; D011239:Prednisolone; C021322:prednisolone hemisuccinate; D004121:Dimethyl Sulfoxide
Pharmacocinétique de la prednisolone administrée sous la forme d'une solution d'acétate de prednisolone dans le diméthysulfoxyde et en association avec des antibiotiques chez la vache.