Serum CPK-BB isoenzyme in the assessment of brain damage in asphyctic term infants.
Serum creatine phosphokinase-BB activities were measured at 4 and at 10 hours of life in 33 asphyctic full-term infants. The infants were followed for a mean period of 16 months. Enzyme activities at 4 hours of life were significantly higher in those neonates who died of severe hypoxic-ischemic encephalopathy or developed neurological sequelae than in those who did not present neurological abnormalities during the follow-up time. The specificity of the enzyme assay in order to predict the neurological outcome was inferior to that of cranial computed tomography or a combined clinical-electroencephalographic evaluation. It appears that the presence of elevated serum creatine phosphokinase-BB activity can be a sensitive indicator of conspicuous brain damage, but it is of limited value to predict the neurological outcome after neonatal asphyxia.
Fernández
F
F
Service of Neonatology, Clínica Infantil, Ciudad Sanitaria La Paz, Madrid, Spain.
Verdú
A
A
Quero
J
J
Pérez-Higueras
A
A
D001238:Asphyxia Neonatorum / Q000097:blood* / Q000150:complications; D003402:Creatine Kinase / Q000097:blood*; D004569:Electroencephalography; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D002534:Hypoxia, Brain / Q000175:diagnosis / Q000201:enzymology*; D007231:Infant, Newborn; D007527:Isoenzymes; D014057:Tomography, X-Ray Computed
D007527:Isoenzymes; D003402:Creatine Kinase