[DNA analysis of early esophageal cancer and epithelium adjacent to the cancer].
DNA distribution of 4 early esophageal cancers and their epithelial adjacent to cancer was analysed using photocytometry technique. In the tissues around the cancer, DNA content of the normal squamous epithelium always showed diploid (2 c) or proliferating diploid (less than 5 c). DNA content of 3 cases of the dysplastic cells in three specimens was predominantly proliferating diploid, comprising 68%, 38.2% and 59.4% but the aneuploid (greater than 5 c), 8%, 2.9% and 21.8%, respectively. In 4 cases of carcinoma in situ, the aneuploid increased to 86.7%, 68.7%, 17.2% and 28.6%, markedly higher than the dysplastic cells. In 3 cases of early esophageal cancer, the aneuploid accounted for 58.8%, 51.1% and 13.6%, similar to carcinoma in situ. The results indicate that in the dysplastic cells, there is a relative high ratio of the aneuploid cells except the increased proliferating diploid. This phenomenon could explain the unstability for dysplasia and might be the earliest manifestation of malignant change of the epithelial cells.
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
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Liu
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Rubio
D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000032:analysis* / Q000235:genetics; D004171:Diploidy; D004848:Epithelium / Q000032:analysis; D004938:Esophageal Neoplasms / Q000032:analysis*; D006801:Humans; D011230:Precancerous Conditions / Q000032:analysis*
D004273:DNA, Neoplasm