Total estradiol and progesterone receptor levels and DNA concentrations in human endometrium with nonuniform postovulatory delay of maturation.
Total estradiol and progesterone receptor levels and DNA concentrations were measured in endometria of four women with nonuniform postovulatory delayed maturation of the epithelium. All four women underwent curettage on Days 21 to 23 of their cycle. The results in these women were compared with results obtained from a control group of women with histologically normal cyclic endometrium. In three women with corpus luteum defect, total estradiol and progesterone receptor levels and DNA concentrations were in the range of midcycle or early secretory normal (control) endometria. In one patient with a normally functioning corpus luteum, the above parameters were similar to those found in the late secretory phase of controls. Summation of the results of the present study along with those previously reported in endometria of women, both with uniform and nonuniform delayed maturation, indicate the possibility of endometrial postacceptorial progesterone defect, which may either be secondary to corpus luteum defect or a result of primary endometrial defect.
Department of Obstetrics and Gynecology B, Meir General Hospital, Kfar Saba, Israel.
I G
IG
Gorodeski
A
A
Sigal
B
B
Lunenfeld
R
R
Beery
A
A
Geier
C M
CM
Bahari
D000328:Adult; D004247:DNA / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D004848:Epithelium / Q000503:physiopathology; D005260:Female; D006801:Humans; D008183:Luteal Phase; D008875:Middle Aged; D011959:Receptors, Estradiol / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*
D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D004247:DNA