[The Schilling test in Biermer's disease, problems of false negative reactions. Apropos of a case].
A case of pernicious anemia in a 30 years old men is described. This disease was typical for the hematologic, immunologic and medullary patterns, for his evolution, but the Schilling test, a dual tracer method, did not confirm the diagnosis. The contradictory of this result can be explained wether by the bias of the test itself, or by the intestinal malabsorption due to the vitamin B12 deficiency, or by other factors like bacterial overgrowth state (associated in the pernicious anemia) and a high level of antibodies to intrinsic factor.
Devidas
A
A
Laboratoire d'Hématologie, Hôpital Jean-Verdier, Bondy.
Jeantils
V
V
Soulier
A
A
Lejeune
F
F
Delzant
G
G
D000328:Adult; D000752:Anemia, Pernicious / Q000175:diagnosis*; D005188:False Negative Reactions; D006801:Humans; D007437:Intrinsic Factor / Q000172:deficiency / Q000276:immunology; D008286:Malabsorption Syndromes / Q000150:complications; D008297:Male; D012546:Schilling Test; D014805:Vitamin B 12 / Q000378:metabolism*; D014806:Vitamin B 12 Deficiency / Q000209:etiology
D007437:Intrinsic Factor; D014805:Vitamin B 12
Test de Schilling dans la maladie de Biermer, problèmes de faux négatifs. A propos d'un cas.