The activity of alkaline phosphatase in the sera of DBA/2NCrj and CBA/BrA mice with calcified tongue lesions.
Spontaneously occurring calcified lesions were found in the tongues of DBA/2NCrj and CBA/BrA mice. In the DBA/2NCrj strain, the frequency of the lesion was 80% (males) and 88% (females). The youngest age of a mouse with this lesion was 18 days after birth, and 3-4 lesions were found in the tongue of 6- to 8-week-old mice. In CBA/BrA mice, 20% of females and 48% of males had the lesions. No significant differences were found in the serum calcium concentrations in high and low lesion-developing strains, but the alkaline phosphatase activities in the high-developing DBA/2NCrj, DBA/LiA, and CBA/BrA strains were higher than in strains with no calcified lesions.
Department of Laboratory Animal Science, Tohoku Dental University, Fukushima, Japan.
Y
Y
Matsushima
T
T
Ikeno
D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D002114:Calcinosis / Q000201:enzymology / Q000662:veterinary*; D002118:Calcium / Q000097:blood; D005260:Female; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA / Q000097:blood*; D008811:Mice, Inbred DBA / Q000097:blood*; D010710:Phosphates / Q000097:blood; D012376:Rodent Diseases / Q000201:enzymology*; D014060:Tongue Diseases / Q000201:enzymology / Q000662:veterinary*
D010710:Phosphates; D000469:Alkaline Phosphatase; D002118:Calcium