Acute mercury chloride intoxication. Effects of hemodialysis and plasma exchange on mercury kinetic.
A 27 year-old man developed after ingestion of mercury chloride, 6 g, a hypovolemic shock, an acute renal failure and a necrosis of the stomach which required a total gastrectomy. The anuria did not improve and required 42 hemodialyses. Subsequent evolution showed numerous complications and the patient died on the 91st day. On admission mercury plasma concentration was 5 mg/L and decreased slowly with an apparent half-life of 226 hours. Hemodialyses were ineffective for mercury elimination: mercury clearances varied between -10 and + 1.5 ml/min. Seventeen mg of mercury were removed by six plasma exchanges: the mercury clearance was mean 17.3 ml/min. Among the extracorporeal elimination methods, plasma exchange appears to be the most efficient for inorganic mercury and it could be usefull in association with chelation therapy at the early phase of the intoxication.
Reanimation Medicale et Centre Anti-Poisons, Hopital Civil, Strasbourg, France.
P
P
Sauder
F
F
Livardjani
A
A
Jaeger
J
J
Kopferschmitt
R
R
Heimburger
C
C
Waller
J M
JM
Mantz
M
M
Leroy
D058186:Acute Kidney Injury / Q000139:chemically induced; D000328:Adult; D006801:Humans; D008297:Male; D008627:Mercuric Chloride / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D008657:Metabolic Clearance Rate; D010951:Plasma Exchange; D006435:Renal Dialysis
D008627:Mercuric Chloride