Renal prostaglandin production is increased during abdominal sepsis in the rat and unaffected by the infusion of different amino acid formulations.
Renal prostaglandin (PG) production was studied in 32 laparotomized (control) and 33 septic rats (cecal ligation and puncture). Control and septic rats were infused for 18 hr with 5% glucose or 5% glucose and one of three amino acid formulations containing 22, 35, or 45% branched chain amino acids. When comparing renal PG production from endogenous precursors in septic versus control rats, significant increases (P less than 0.01) could be detected for PGE2, 6-keto-PGF1 alpha, and TxB2. The infusion of either 5% glucose alone or 5% glucose with 4.25% of any of the three amino acid formulations tested did not change renal PG production in either control or septic rats.
Department of Surgery, University of Cincinnati Medical Center, Ohio 45267-0558.
H R
HR
Freund
U O
UO
Barcelli
M
M
Muggia-Sullam
R
R
LaFrance
L S
LS
Gallon
J E
JE
Fischer
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000005:Abdomen; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001424:Bacterial Infections / Q000378:metabolism*; D015232:Dinoprostone; D005947:Glucose / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013929:Thromboxane B2 / Q000096:biosynthesis
D000596:Amino Acids; D011453:Prostaglandins; D011458:Prostaglandins E; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D005947:Glucose; D015232:Dinoprostone