Plasma catecholamine levels in the postoperative period in complication-free and "paralytic" ileus patients.
Plasma catecholamine concentrations were compared in a group of postoperative "paralytic" ileus patients and in another group of patients, who had undergone medium-size abdominal operations followed by uneventful recovery. The plasma epinephrine level was significantly in the former group, whereas no such difference was observed in the norepinephrine concentration. The data appear to confirm that the epinephrine released from the adrenal medulla appreciably contributes to the development of "paralytic" ileus. The therapeutically effective major tranquillizer and alpha-receptor blocking drug, trifluperidol, was found to reduce both epinephrine and norepinephrine levels in "paralytic" ileus patients. The decrease of the plasma epinephrine level was the higher, the greater its initial concentration. These findings seem to support the decisive role of increased catecholamine release in the development of postoperative motor inhibition ("postoperative" ileus) and also explain the success of sympatholytic treatment in such cases, i.e. the return of normal peristalsis.
Institute of Experimental Surgery, University Medical School, Szeged, Hungary.
K
K
Tárnoky
J
J
Szenohradszky
G
G
Petri
D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D004837:Epinephrine / Q000097:blood*; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D011183:Postoperative Complications / Q000097:blood*; D011184:Postoperative Period; D014272:Trifluperidol / Q000627:therapeutic use
D014272:Trifluperidol; D009638:Norepinephrine; D004837:Epinephrine