Age-related changes in the rates of polypeptide chain elongation.
The time of an average polypeptide chain synthesis, ts, in the liver and brain cortex of rats of various age--from the 17th day of prenatal life up to the 24th month of the postnatal period--was estimated. At the end of the prenatal period the value of t is much higher than in postnatal life. In newborns, the t value is minimal, showing a gradual increase during the postnatal development. Determination of an average molecular mass of newly synthesized polypeptides demonstrated that the increase of t in postnatal life is due to the decrease of the rate of polypeptide chain elongation.
I.M.Sechenov First Moscow Medical Institute, U.S.S.R.
P Z
PZ
Khasigov
Nikolaev AYa
D000375:Aging; D000818:Animals; D002540:Cerebral Cortex / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D005314:Embryonic and Fetal Development; D005333:Fetus; D007700:Kinetics; D008099:Liver / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D010441:Peptide Chain Elongation, Translational; D011132:Polyribosomes / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains