Morphometric study of myocardial changes during puromycin aminonucleoside induced nephropathy in rats.
Puromycin aminonucleoside (PAN)-treated rats developed a severe nephrotic syndrome. Morphometric analysis of the hearts revealed significant differences between treated and control rats regarding nuclear index, reticulin index, nuclear and myocellular transsectional area, capillary number and transsectional area of capillaries. These differences were comparable with those induced by adriamycin. It is suggested that PAN can induce morphometrically measurable abnormalities in hearts of rats comparable to the morphometric changes seen after adriamycin treatment. The question of whether nephropathy, a result of both DOX and PAN treatment of rats, adds to or perhaps even causes doxorubicin - induced cardiomyopathy remains unclear.
Department of Oncology, Free University Hospital, Amsterdam, The Netherlands.
W J
WJ
van der Vijgh
D
D
Van Velzen
J S
JS
Van der Poort
H M
HM
Schlüper
K
K
Mross
J
J
Feijen
H M
HM
Pinedo
D000818:Animals; D001835:Body Weight; D006321:Heart / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000473:pathology*; D009404:Nephrotic Syndrome / Q000139:chemically induced / Q000473:pathology*; D011692:Puromycin Aminonucleoside; D051381:Rats; D011919:Rats, Inbred Strains
D011692:Puromycin Aminonucleoside