Synthesis of side chain-modified iodothyronines.
New side chain-modified iodothyronines have been synthesized. They include: 1-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]-1,2-ethanediol (T2EG); alpha-hydroxy-4-(4-hydroxyphenoxy)-3,5-diiodobenzeneacetic acid (T2HAA) and their 4-methyl ether derivatives (MT2EG, MT2HAA); 1-[4-(4-hydroxyphenoxy)-3,5-diiodophenyl]-2-aminoethanol (T2EA); 1-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-1,2-ethaned iol (T3EG); 1-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-aminoetha nol (T3EA); and alpha-hydroxy-4-(3-iodo-4-hydroxyphenoxy)-3,5-diiodobenzeneacet ic acid (T3HAA). These model compounds are being used to study thyroid hormone metabolism and to determine structure-activity relationships of iododiphenylether derivatives.
Han
S Y
SY
Department of Chemistry, University of Pennsylvania, Philadelphia.
Gordon
J T
JT
Bhat
K
K
Dratman
M B
MB
Joullié
M M
MM
D002851:Chromatography, High Pressure Liquid; D014284:Triiodothyronine / Q000378:metabolism*
D014284:Triiodothyronine