[Effects of equal amounts of linoleic acid in orally administered, polyunsaturated phospholipids or in safflower oil on blood lipoproteins].
The effects of polyenylphosphatidylcholine in a dosage of 10 g per day were compared with an equimolar amount of linoleic acid in 7 g safloroil per day in 8 healthy subjects for 3 weeks. The concentrations of cholesterol, triglycerides, phospholipids, apolipoproteins A-I, A-II and B were measured in serum, as well in VLDL, LDL, HDL, HDL2, HDL3 on the day before, after 2 and 3 weeks of application and 6 months after the experiment. The diet was controlled 10 days before and during the experiment using the dietary recall method. According to the dietary records there was an increase of fat supply during application of polyenylphosphatidylcholine inhibiting decrease of LDL cholesterol, which was observed with safloroil. Phospholipid concentrations increased significantly with polyenylphosphatidylcholine in VLDL. Apolipoprotein B in LDL was significantly decreased by both substances. Apolipoprotein A-I and A-II in HDL increased significantly with polyenylphosphatidylcholine. With safloroil this effect was limited to apolipoprotein A-I, but less impressive. The effects of both substances are comparable in the decrease of apolipoprotein B and probably cholesterol. A special effect of polyenylphosphatidylcholine was observed on phospholipids in VLDL and on apolipoprotein A-I and A-II in HDL.
Medizinische Poliklinik, Universität München.
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Spann
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Wolfram
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Zöllner
D000284:Administration, Oral; D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D010713:Phosphatidylcholines / Q000008:administration & dosage*; D010938:Plant Oils / Q000008:administration & dosage*; D012450:Safflower Oil / Q000008:administration & dosage*
D001053:Apolipoproteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008041:Linoleic Acids; D008074:Lipoproteins; D010713:Phosphatidylcholines; D010938:Plant Oils; C029449:polyene phosphatidylcholine; D012450:Safflower Oil; D002784:Cholesterol; D019787:Linoleic Acid
Die Wirkungen gleicher Mengen Linolsäure in oral zugeführten, mehrfach ungesättigten Phospholipiden oder in Safloröl auf die Lipoproteine des Plasmas.