The production of 99mTc-labeled conjugated antibodies using a cyclam-based bifunctional chelating agent.
A bifunctional chelating agent (BFCA) based on a macrocyclic amine, cyclam, was used to form specifically 99mTc labeled rabbit-anti-HSA-antibodies. This study demonstrates the feasibility of forming a highly stable cyclam-based 99mTc-BFCA with its subsequent conjugation to antibodies.
Franz
J
J
Department of Radiology, University of Missouri-Columbia.
Volkert
W A
WA
Barefield
E K
EK
Holmes
R A
RA
D000906:Antibodies; D002614:Chelating Agents; D006571:Heterocyclic Compounds; D006801:Humans; D007202:Indicators and Reagents; D012709:Serum Albumin; D013667:Technetium
D000906:Antibodies; D002614:Chelating Agents; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D012709:Serum Albumin; C054749:1-(3-aminopropyl)-4-methyl-1,4,8,11-tetraazacyclotetradecane; D013667:Technetium