Trimebutine-induced phase III-like activity in infants with intestinal motility disorders.
Duodenal manometric recordings were performed in five male children (mean age 11.7 +/- 6.8 months) suffering from severe digestive pathology with clinical findings of dysmotility; they required total parenteral nutrition: one case of enteropathy following intestinal resection for congenital small bowel atresia, and four cases of intestinal pseudoobstruction. The basal 3-h fasting recordings showed complete disorganization of interdigestive activity characterized by an absence of migrating motor complexes and a marked basal hypomotility with motor indices lower than in control subjects. Intravenous trimebutine (3 mg/kg) produced a phase III-like activity 88 +/- 121 s after administration in four cases. The activity lasted 236 +/- 105 s and had a mean frequency of 11.75 +/- 0.86 waves/min. It was propagated aborally in the two patients having two duodenal recording sites. Trimebutine-induced phase III activity was followed by signs of peristalsis in two patients.
Boige
N
N
Service de Gastroentérologie Pédiatrique, Hôpital Bretonneau, Paris, France.
Cargill
G
G
Mashako
L
L
Cezard
J P
JP
Navarro
J
J
D001565:Benzoates / Q000494:pharmacology*; D002675:Child, Preschool; D004386:Duodenum / Q000187:drug effects / Q000503:physiopathology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D007418:Intestinal Pseudo-Obstruction / Q000503:physiopathology*; D008297:Male; D008365:Manometry; D014287:Trimebutine / Q000494:pharmacology*
D001565:Benzoates; D014287:Trimebutine