[Principle of reorganizing the functional interrelations of brain structures in action on the dopamine system of dogs].
In dogs, the influence of chronic administration of the agonist (L-DOPA) and antagonist (haloperidol) of central dopamine processes on functional interrelations of the brain structures was studied by dynamics of evoked potentials. Cortical-subcortical relations during formation of a motor habit are described in intact animals: basic functional regimes of central integration are singled out--sensory and motor one. Change of their equilibrium is the general principle of systemic reconstructions elicited by differently directed interferences in dopamine processes. Against the background of chronic administration of haloperidol, a sensory-motor imbalance is formed due to uniform functioning of the basal ganglia as analyzer of the signal stimulus; simultaneously the utilization of afferentation elicited by the movement is limited. A variant is revealed of intercentral relations corresponding to bradykinesia development. Under chronic administration of L-DOPA, interrelations of sensory and motor regimes become competitive; basal ganglia are provided with nontypical kinds of afferentations. Intercentral relations variant is examined corresponding to development of psycho-motor excitation. The results are discussed in connection with pathogenic and compensatory mechanisms of some symptoms of parkinsonism and schizophrenia.
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Kachalova
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Popova
D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D003214:Conditioning, Classical / Q000187:drug effects; D004285:Dogs; D004298:Dopamine / Q000502:physiology*; D004567:Electrodes, Implanted; D005071:Evoked Potentials / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D009044:Motor Cortex / Q000187:drug effects / Q000502:physiology; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D014793:Visual Cortex / Q000187:drug effects / Q000502:physiology
D011954:Receptors, Dopamine; D007980:Levodopa; D006220:Haloperidol; D004298:Dopamine
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