Selachyl alcohol as an oral antihypertensive agent: a preliminary note.
Selachyl alcohol (SA) is a mono-oleyl glyceryl ether. It has certain biologic activities similar to those of the antihypertensive neutral renomedullary lipid (ANRL) derived from the renal papilla and its renomedullary interstitial cells (RIC). These include a vaso-depressor effect following bolus injection and a requirement for hepatic activation for the development of biological activity. In view of this similarity to ANRL, it appeared worthwhile to test the antihypertensive action of SA when given via the GI tract. Accordingly, pure SA was given either by gavage or by tube into the stomach or duodenum of one-kidney, one-clip hypertensive rats (5-10 mg per dose). The role of hepatic activation was demonstrated by comparing the BP response to bolus injection of SA and ANRL with and without the presence of an intact circulation to the liver. Administration of SA via the GI tract resulted in a significant decline in BP without tachycardia or weight loss. In the absence of a circulation to the liver, neither SA nor ANRL was active. SA appears to be an effective antihypertensive agent when given via the GI tract.
Department of Pathology, University of Tennessee, Memphis.
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Muirhead
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LW
Byers
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B
Brooks
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JA
Pitcock
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Brown
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Dowell
D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects; D005233:Fatty Alcohols / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006978:Hypertension, Renovascular / Q000188:drug therapy* / Q000503:physiopathology; D008102:Liver Circulation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000959:Antihypertensive Agents; D005233:Fatty Alcohols; C009224:selachyl alcohol