Free energy and time economy for the mutual selection of monomers in biosynthesis, primarily protein synthesis.
The starting point of this work is the fact that the correction of errors in biosynthesis must be paid for by an increased dissipation (free energy loss) or a time delay. Further, a low accuracy is wasteful in this respect as the cell then produces a number of non-functioning products with a significant "production cost". One can then look for the situations of best "economy" for the selection processes. This is particularly obvious in reciprocal selections, where in some cases a substrate A shall be selected but discriminated against a competitor B, and in other cases, the opposite is true, B shall be selected with A as a competitor. It can be expected only in certain symmetric situations that these reciprocal selections are made in an equal way. Because one substrate shall be selected more often or it may be more relevant for the product, it may occur in higher concentrations and/or be selected more accurately (at a higher cost). The opposite selection may then be less accurate. The work studies various aspects of this.
Blomberg
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Department of Theoretical Physics, Royal Institute of Technology, Stockholm, Sweden.
D000818:Animals; D008954:Models, Biological; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000378:metabolism; D012641:Selection, Genetic; D013816:Thermodynamics