Amiloride prevents thiazide-induced intracellular potassium and magnesium losses.
To study the effect of a combination of amiloride, 5 mg, and hydrochlorothiazide, 50 mg (Moduretic), on plasma and skeletal muscle electrolytes in patients on long-term diuretic therapy (greater than 1 year) for arterial hypertension and/or congestive heart failure, 58 patients were recruited. Fifty-five patients completed the study, 27 controls and 28 in the treatment group. The Moduretic group demonstrated a significant increase in skeletal muscle potassium and magnesium values and a significant decrease in systolic blood pressure after 6 months on therapy. There was no significant change in these parameters in the control group. It is concluded that this combination of amiloride and hydrochlorothiazide is capable of preserving the internal and external balance of potassium and magnesium on a long-term basis in the patient categories studied.
Department of Internal Medicine, University of Umeå, Sweden.
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Dyckner
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Wester
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Widman
D000368:Aged; D000584:Amiloride / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D001834:Body Water / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004338:Drug Combinations; D005260:Female; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects*; D006973:Hypertension / Q000188:drug therapy; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D011897:Random Allocation
D004338:Drug Combinations; D006852:Hydrochlorothiazide; D000584:Amiloride; D008274:Magnesium; D011188:Potassium