Further localization of ETS1 indicates that the chromosomal rearrangement in Ewing sarcoma does not occur at fra(11)(q23).
A genomic probe homologous to 5.4 kb of the c-ets-1 gene was hybridized in situ to chromosomes expressing fra(11)(q23). This probe hybridized distal to the fragile site, which is just distal to the midpoint of band 11q23.3. This result localizes ETS1 from the FRA11B locus to 11q24. The result also distinguishes the FRA11B locus from the site of translocation at 11q23-q24 in the Ewing sarcoma- and peripheral neuroepithelioma-specific t(11;22), indicating that the chromosomes of a previously reported patient heterozygous for fra(11)(q23) did not rearrange at this fragile site to give rise to Ewing sarcoma. This adds to the mounting evidence against individuals with fragile sites being predisposed to developing cancer.
Department of Histopathology, Adelaide Children's Hospital, Australia.
R N
RN
Simmers
G R
GR
Sutherland
D002871:Chromosome Banding; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes; D012512:Sarcoma, Ewing / Q000235:genetics*
D005819:Genetic Markers