Differences between early and late-onset Alzheimer's disease.
Alzheimer's disease of early onset versus that of late onset represent different syndromes, with distinct neuropathologies. Patients with early onset disease exhibit a more severe and more widespread loss of neurons from cortical and sub-cortical regions and the neurochemical changes involve not only the cholinergic system, but also neurons containing GABA, somatostatin and norepinephrine.
Iversen
L L
LL
Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories Terlings Park, Harlow, England.
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002452:Cell Count; D006801:Humans; D009474:Neurons / Q000473:pathology*