[Effect of L-dihydroxyphenylalanine on rat behavior and on catecholamine metabolism of the brain in rats with different degrees of emotional-behavioral reactivity].
The effect of L-DOPA in combination with benserazide (Madopar), administered intraperitoneally on the rat behaviour and L-DOPA, DA, NE, DOPAC content in rat brain structures was studied depending on the level of the animals' emotional-behavioural reactivity. The results indicate that L-DOPA metabolism in striatum, n. accumbens and hypothalamus in intact animals with high emotional reactivity was the greatest. Administration of Madopar (50 mg/kg) induced significant behavioural disturbances in animals with less emotional-behavioural response patterns. In contrast, 125 mg/kg Madopar completely abolished individual differences in the rats' behaviour and DA, but not L-DOPA and DOPAC content. The correlation between behavioural and biochemical differences in two groups of animals is discussed in view of distinctions in L-DOPA and DA compartmentation process.
Bondarenko
N A
NA
Miroshnichenko
I I
II
Kudrin
V S
VS
Bondarenko
N A
NA
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001545:Benserazide / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry; D002395:Catecholamines / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations / Q000494:pharmacology; D004347:Drug Interactions; D004644:Emotions / Q000187:drug effects*; D007980:Levodopa / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D051381:Rats
D002395:Catecholamines; D004338:Drug Combinations; C005177:benserazide, levodopa drug combination; D015102:3,4-Dihydroxyphenylacetic Acid; D007980:Levodopa; D001545:Benserazide
Vliianie L-dioksifenilalanina na povedenie krys i metabolizm katekholaminov mozga krys s razlichnym urovnem émotsional'no-povedencheskoĭ reaktivnosti.