Recruitment experience in the Aspirin Myocardial Infarction Study.
The Aspirin Myocardial Infarction Study (AMIS) was a randomized double-masked trial of the efficacy of aspirin in the secondary prevention of coronary heart disease. Thirty clinics randomized 4524 post-myocardial infarction patients to aspirin or placebo treatment. Recruitment was achieved in 14 months as planned, but nearly half of the patients were not randomized until the last 5 months of the recruitment period. Direct public appeal, self-referral, and review of hospital records provided 75% of the participants. Physician referral accounted for only 15%. The demographic characteristics of the sample revealed two thirds to be 50 years of age or older, 90% to be male, and 90% to be white.
Schoenberger
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D000328:Adult; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000517:prevention & control*; D010361:Patients; D011897:Random Allocation
D001241:Aspirin