Subsarcolemmal vermiform deposits in skeletal muscle, associated with familial cardiomyopathy: report of two cases of a new entity.
Distinctive subsarcolemmal acid phosphatase-positive crescents were found in many muscle fibers of triceps muscle biopsies from 2 siblings with cardiomyopathy. The crescents appeared as dense osmophilic material in irregular vermiform arrays on electron microscopy. However, both patients had clinically normal skeletal muscle function. These 2 cases are believed to represent a rare familial myopathy affecting cardiac and skeletal muscle.
Department of Pathology, Hospital for Sick Children, Toronto, Ont., Canada.
A
A
Calderon
L E
LE
Becker
E G
EG
Murphy
D009202:Cardiomyopathies / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008854:Microscopy, Electron; D009132:Muscles / Q000378:metabolism* / Q000648:ultrastructure; D009135:Muscular Diseases / Q000150:complications / Q000378:metabolism / Q000473:pathology; D012508:Sarcolemma / Q000378:metabolism* / Q000648:ultrastructure