In vitro susceptibility of Mycobacterium avium complex to antibacterial agents.
In vitro agar dilution susceptibility studies were performed utilizing 20 isolates (24 against rifamycin) of Mycobacterium avium complex against several antimicrobial agents not routinely tested in the mycobacteriology laboratory. Thirteen strains were susceptible to gentamicin at 4 micrograms/ml, 20 to amikacin at 8 micrograms/ml, 18 to streptomycin at 8 micrograms/ml, 20 to kanamycin at 8 micrograms/ml, 20 to trimethoprim/sulfamethoxazole at 2 micrograms/ml, 12 to sulfisoxazole at 10 micrograms/ml, 14 to rifabutin at 1 microgram/ml. No activity was found with penicillin G, cephapirin, moxalactam, vancomycin, clindamycin, erythromycin, trimethoprim, or minocycline. This data suggests a potential use of trimethoprim/sulfamethoxazole, sulfisoxazole, amikacin, gentamicin, and kanamycin in the treatment of infections caused by this group of organisms.
Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas.
C E
CE
Davis
J L
JL
Carpenter
S
S
Trevino
J
J
Koch
A J
AJ
Ognibene
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004355:Drug Stability; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects*
D000900:Anti-Bacterial Agents