Effect of a sublethal dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin on interscapular brown adipose tissue of rats.
The effect of a sublethal dose (15 micrograms/kg) of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was studied in selected tissues of male Sprague-Dawley rats by histological techniques 1, 3, 7 and 14 days after TCDD dosage. Histology of the heart, muscle, white adipose tissue, pancreas and the thyroid was unremarkable and that of the liver was found in agreement with previous reports. However, considerable changes were seen in interscapular brown adipose tissue (IBAT) of TCDD-treated rats. Initial accumulation followed by depletion of lipids, appearance of glycogen, cellular, mitochondrial and nuclear transformations were observed. In conjunction with other experiments it is concluded that a sublethal dose of TCDD alters fat and glucose metabolism in IBAT.
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66103.
K
K
Rozman
D
D
Pereira
M J
MJ
Iatropoulos
D002001:Adipose Tissue, Brown / Q000187:drug effects* / Q000648:ultrastructure; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004147:Dioxins / Q000633:toxicity*; D008099:Liver / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins