"Masked" Philadelphia chromosome resulting from a t(X;22) in chronic myeloid leukemia.
A rare cytogenetic finding in chronic myeloid leukemia is reported. It consisted in a "masked" Philadelphia chromosome, resulting from an unusual translocation between chromosomes #22 and X. The t(X;22) was present in 100% of direct and cultured bone marrow cell preparations. Chromosome #9 did not seem to be involved in the formation of the Ph marker. Involvement of the X chromosome in karyotypic changes of hematologic diseases, with particular respect to chronic myeloid leukemia, is discussed.
Barbata
G
G
Dipartimento di Biologia Cellulare e dello Sviluppo A. Monroy, Sezione di Genetica, Università di Palermo, Italy.
Carbone
P
P
Giglio
M C
MC
Santoro
A
A
Granata
G
G
D002892:Chromosomes, Human, Pair 22; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic; D014960:X Chromosome