Fetal catecholamines and the Apgar score.
The association between Apgar score, pH and catecholamine levels was investigated in 181 newborn infants with a gestational age between 29 and 43 completed weeks. Umbilical arterial blood was obtained before the first breath with the double clamp technique and pH was measured. Plasma adrenaline and noradrenaline were analyzed by high performance liquid chromatography. The Apgar score at 1 minute was above or equal to seven in 167 infants. Forty-four per cent of these infants had pH below 7.25. A negative correlation between log noradrenaline and pH (r = 0.52, p less than 0.001) and between log adrenaline and pH (r = 0.40, p less than 0.001) was found. In 14 infants the Apgar score was below seven. The median pH was 7.21 (range 7.02-7.32). Also in this group a negative correlation between log noradrenaline and pH (r = 0.60, p less than 0.05) and between log adrenaline and pH (r = 0.77, p less than 0.01) was noted. We concluded that the Apgar score is an insufficient measure of fetal asphyxia defined as fetal acidosis but rather reflects the vitality of the newborn.
Department of Obstetrics and Gynecology, Huddinge University Hospital, Karolinska Institute, Sweden.
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L
Nylund
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I
Dahlin
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H
Lagercrantz
D001034:Apgar Score; D004837:Epinephrine / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn / Q000097:blood*; D008297:Male; D009638:Norepinephrine / Q000097:blood*
D009638:Norepinephrine; D004837:Epinephrine