Percutaneous absorption in preterm infants.
The skin of preterm infants varies considerably in its level of maturity. To understand skin absorption in premature infants better, we report a technique for the assessment of percutaneous absorption at various gestational and postnatal ages using stable, isotope-labeled (13C6) benzoic acid. Our results indicate that in the preterm infant, this method detects enhanced skin absorption in the first postnatal days, which declines over three weeks to that expected of a full-term infant. This approach also indicates an inverse relationship between gestational age and skin absorption, as well as postnatal age and skin absorption. The reported technique is a safe and noninvasive method using a model skin penetrant for the study of percutaneous absorption in preterm infants from which basic data may be derived to add to our understanding of skin barrier function.
West
D P
DP
Department of Dermatology, University of Illinois, Chicago 60680.
Halket
J M
JM
Harvey
D R
DR
Hadgraft
J
J
Solomon
L M
LM
Harper
J I
JI
D001565:Benzoates; D019817:Benzoic Acid; D003404:Creatinine; D005260:Female; D006801:Humans; D006868:Hydrolysis; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D011247:Pregnancy; D012869:Skin Absorption
D001565:Benzoates; D019817:Benzoic Acid; D003404:Creatinine