Rheological modifications of mucus in chronic bronchitic patients after treatment with stepronine-lysine salt.
To investigate the characteristics of bronchial mucus in bronchopneumopathic patients before and after stepronine-lysine salt treatment, a rheological double-blind randomised study has been performed. The assessment of the rheological behaviour of bronchial secretions was performed using a coaxial cylinder rheometer set up for dynamic test with sinusoidal oscillation. While the placebo group did not show significant modifications in the viscosity and elasticity parameters, in the stepronine group a significant viscosity reduction was found.
Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
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PC
Braga
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Bossi
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Allegra
D000328:Adult; D000368:Aged; D001991:Bronchitis / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D004311:Double-Blind Method; D004548:Elasticity; D005100:Expectorants; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D011897:Random Allocation; D012212:Rheology; D013183:Sputum / Q000187:drug effects*; D013440:Sulfides; D013876:Thiophenes; D014783:Viscosity
D005100:Expectorants; D013440:Sulfides; D013876:Thiophenes; C035227:stepronin; D005998:Glycine