[Effects and properties of sodium nucleinate used as a pyrogen working standard. 4. Acquired tolerance in rabbits following repeated intravenous injections of sodium nucleinate].
In rabbits, the repeated i. v. injection of bacterial lipopolysaccharide very quickly induces partial pyrogen tolerance if the injections are made at intervals of 1d. Evidently, this tolerance is without effect on the temperature increases due to subsequent sodium nucleinate injections, i. e. there is no cross tolerance between the bacterial lipopolysaccharide used for comparison and sodium nucleinate. A repeated sodium nucleinate injection, if made at intervals of 1d, does not induce pyrogen tolerance either under the experimental conditions chosen. Evidently, the temperature increases due to subsequent injections of the bacterial lipopolysaccharide used for comparison are not affected by preceding sodium nucleinate injections.
Institut für Arzneimittelwesen der DDR, Berlin.
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D000818:Animals; D004361:Drug Tolerance; D007275:Injections, Intravenous; D009696:Nucleic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D011749:Pyrogens / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D012015:Reference Standards
D009696:Nucleic Acids; D011749:Pyrogens; C013683:sodium nucleinate
Uber Wirkungen und Eigenschaften des als Pyrogen-Arbeitsstandard verwendeten Natriumnucleinats. 4. Mitteilung: Untersuchungen zur Toleranzbildung bei Kaninchen nach wiederholter intravenöser Injektion von Natriumnucleinat.