Renal function in patients undergoing major surgery under moderate normovolemic hemodilution.
A prospective randomized study on 100 patients with cholelithiasis, who were scheduled for cholecystectomy was carried out. 50 patients were hemodiluted (Hctr. 29-27%). In both groups, hemodiluted and non-hemodiluted patients, the following parameters were studied: renal function as regards glomerular filtration (creatine clearance, etc.) and also with reference to the concentrative capacity of the kidneys (free water and osmolar clearances). The results obtained show that M.N.H. significantly improves renal function. From the practical point of view we can conclude that the improved "performance" of the kidney in hemodiluted patients minimizes the nephrotoxis effects of many drugs and anaesthetic agents.
Vara-Thorbeck
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R
Faculdad de Medicina, Catedra de Patologia y Clinica Quirurgica II, Universidad de Granada.
Guerrero Fernandez Marcote
J A
JA
D001810:Blood Volume; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000601:surgery*; D006438:Hemodilution; D006801:Humans; D007677:Kidney Function Tests; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D014882:Water-Electrolyte Balance