Informational parameters of nucleic acid and molecular evolution.
From the point of view of information theory, a statistical analysis of 2000 nucleic acid sequences (732 coding regions and 1177 non-coding regions) is given. The sequences are grouped into 20 categories. The probability-order-difference (POD) matrix is defined which is used to analyse the evolutionary distance of any two categories of sequences. The informational parameters D1, D2 and X = (1 + D1/D2)-1 and F are calculated for each sequence and averaged in each category. The statistical dependence of these parameters on molecular evolution is discussed. It is found that [X] is a good statistical quantity which describes the vocabulary compositions as well as the grammatical constructions of the genetic language. From the statistical analysis it is shown that [X] may play an important role in investigating the evolutionary level of nucleic acid molecules.
Luo
L F
LF
Physics Department, Inner Mongolia University, Huhehote, China.
Tsai
L
L
Zhou
Y M
YM
D001483:Base Sequence; D005075:Biological Evolution; D005815:Genetic Code; D007257:Information Theory; D009696:Nucleic Acids; D011336:Probability
D009696:Nucleic Acids