Crystal structures of the complex of porcine pancreatic elastase with two valine-derived benzoxazinone inhibitors.
The crystal structures of porcine pancreatic elastase complexed to two similar benzoxazinone inhibitors are reported to 2.09 A and 1.76 A resolution, and refined to conventional R factors of 0.153 and 0.172.
Radhakrishnan
R
R
Department of Biochemistry and Biophysics, Texas A & M University, College Station 77843.
Presta
L G
LG
Meyer
E F
EF
Wildonger
R
R
D000595:Amino Acid Sequence; D000818:Animals; D048588:Benzoxazines; D002219:Carbamates; D006860:Hydrogen Bonding; D008958:Models, Molecular; D010078:Oxazines; D010179:Pancreas / Q000201:enzymology*; D010196:Pancreatic Elastase; D013552:Swine; D014961:X-Ray Diffraction
D048588:Benzoxazines; D002219:Carbamates; D010078:Oxazines; C054778:(1-(5-methyl-4-oxo-4H-3,1-benzoxazin-2-yl)-2-methylpropyl)carbamic acid 1,1-dimethylethyl ester; C054779:(1-(5-chloro-4-oxo-4H-3,1-benzoxazin-2-yl)-2-methylpropyl)carbamic acid 1,1-dimethylethyl ester; D010196:Pancreatic Elastase