Phenytoin pharmacokinetics in the rabbit: evidence of rapid autoinduction.
Phenytoin pharmacokinetics were studied during continuous intravenous infusion in 12 New Zealand white rabbits. The mean clearance at 40 hours (5.1 +/- 1.1 ml/min per kg; mean +/- SE) was significantly greater than that at 16 hours (3.1 +/- 0.5 ml/min per kg; p less than 0.05). These data suggest that with chronic administration, autoinduction of metabolism results in an increase in the rate of phenytoin clearance in the rabbit.
Cusack
B J
BJ
Clinical Pharmacology & Gerontology Research Unit, VA Medical Center, Boise, Idaho.
Tesnohlidek
D A
DA
Loseke
V L
VL
Eggerth
R M
RM
Olson
R D
RD
D000818:Animals; D006207:Half-Life; D007262:Infusions, Intravenous; D008657:Metabolic Clearance Rate; D010672:Phenytoin / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits
D010672:Phenytoin