Platelet membrane fluidity identifies a clinical subtype of Alzheimer's disease.
1. The fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene (DPH) in labeled platelet membranes, an index of membrane fluidity, identifies a prominent subgroup (approx. 50%) of patients with Alzheimer's disease who manifest distinct clinical features. 2. We review an integrated series of studies that explore both the clinical significance of this finding and the biological basis for the platelet membrane alteration.
Department of Psychiatry, University of Pittsburgh School of Medicine, PA.
G S
GS
Zubenko
B M
BM
Cohen
C F
CF
Reynolds
F
F
Boller
I
I
Teply
B
B
Chojnacki
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000145:classification / Q000175:diagnosis; D001792:Blood Platelets / Q000502:physiology* / Q000648:ultrastructure; D002784:Cholesterol / Q000097:blood; D003863:Depression / Q000097:blood; D004161:Diphenylhexatriene; D005260:Female; D005454:Fluorescence Polarization; D006801:Humans; D008297:Male; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000097:blood; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood
D008563:Membrane Lipids; D010743:Phospholipids; D004161:Diphenylhexatriene; D002784:Cholesterol