The morphological characteristics and ultrastructural aspects of cervical ripening induced by sulprostone.
Cervical tissue biopsies from fifteen pregnant women who were seeking a second trimester elective abortion were examined before and after sulprostone systemic administration, to evaluate the hystological and ultrastructural modifications. While light microscopy showed an increase in vascularity and a submucosal edema with an infiltration of inflammatory cells, electron microscopy pointed out a complete dissociation of collagen fibers with a large increase of basic substance constituents. These features are similar to modifications found in the ripening process at term, demonstrating that sulprostone can be useful to prime uterine cervix.
Università degli Studi di Napoli, II Facoltà di Medicina e Chirurgia Ginecologia ed Ostetricia.
A
A
Di Lieto
D
D
Catalano
M
M
Campanile
R
R
Negri
G
G
Albano
A
A
Dell'Isola
A
A
Paladini
G R
GR
Orlandi
D000019:Abortifacient Agents / Q000494:pharmacology*; D000020:Abortifacient Agents, Nonsteroidal / Q000494:pharmacology*; D000028:Abortion, Induced; D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D003094:Collagen / Q000378:metabolism; D003238:Connective Tissue / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D015232:Dinoprostone / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D011459:Prostaglandins E, Synthetic; C016767:sulprostone; D003094:Collagen; D015232:Dinoprostone