Acute interstitial nephritis following enterobacteriaceae sepsis.
A 52-year-old male developed acute renal failure (ARF) following enterobacteriaceae sepsis. The cause of renal failure was remarkable for prolonged, slow, and incomplete recovery. Recurrence of enterobacteriaceae infection was associated with fever, cutaneous rash, eosinophilia, and elevated IgE level. Renal biopsy and gallium scan studies confirmed the diagnosis of acute interstitial nephritis. The temporal relationship between the first episode of sepsis and the precipitation of ARF and the development of rash, eosinophilia, and elevated IgE level in association with recurrence of infection indicated the role of bacterial antigen in the induction of immune-mediated injury.
Singhal
P C
PC
Department of Medicine, Long Island Jewish Medical Center, Jamaica, New York.
Horowitz
B
B
Molho
L
L
D003876:Dermatitis, Atopic / Q000209:etiology; D004756:Enterobacteriaceae Infections / Q000097:blood / Q000276:immunology; D004802:Eosinophilia / Q000209:etiology / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000209:etiology* / Q000473:pathology; D012008:Recurrence
D007073:Immunoglobulin E