Source of elevated serum mitochondrial creatine kinase activity in patients with malignancy.
Mitochondrial creatine kinase (CK-mit) is increased in cancer tissues of the digestive tract. There is no difference in molecular weight, electrophoretic and kinetic properties between the isoenzymes extracted from the tumor and those from the adjacent normal tissues. High non-CK-M/total CK activity ratios in some sera from cancer patients probably reflect leakage of CK-mit from the tumor tissues.
Okano
K
K
School of Allied Health Sciences, Yamaguchi University, Ube, Japan.
Yamamoto
K
K
Ohba
Y
Y
Matsumura
K
K
Miyaji
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002852:Chromatography, Ion Exchange; D003402:Creatine Kinase / Q000097:blood*; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000201:enzymology*
D007527:Isoenzymes; D003402:Creatine Kinase