Increased plasma free fatty acid and triglyceride levels after single administration of toluene in rabbits.
Changes of plasma lipids (triglyceride, TG: total cholesterol, Cho; and phospholipids, PL), free fatty acid (FFA), and blood glucose (BG) were studied in male rabbits after toluene administration (0.5 g/kg per os). Hypertriglyceridemia was observed at and after 2 h. Plasma FFA and BG were elevated temporarily during the early stage and lowered gradually thereafter. Initially, plasma Cho and PL were virtually unchanged, but the Cho level increased slowly after 6 h. The hypertriglyceridemia observed may have some adverse effects on heart function.
Department of Legal Medicine, Shimane Medical University, Izumo, Japan.
S
S
Takahashi
K
K
Tanabe
C
C
Maseda
H
H
Shiono
Y
Y
Fukui
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D008297:Male; D010743:Phospholipids / Q000097:blood; D011817:Rabbits; D014050:Toluene / Q000097:blood / Q000633:toxicity*; D014280:Triglycerides / Q000097:blood*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D014280:Triglycerides; D014050:Toluene; D002784:Cholesterol