Effect of acute potassium depletion and thiazide treatment on blood glucose in the normal rat.
The effect of potassium depletion and a thiazide diuretic on glucose metabolism was investigated in male rats. Potassium depletion was induced by potassium-deficient diet and ion-exchange resin by stomach tube for 5 days. Plasma and muscle potassium was reduced by 30% (P less than 0.001), and fasting blood glucose concentration was elevated by 20% (P greater than 0.025) by potassium depletion. Hydroflumethiazide 10 mg/kg given orally once daily for 8 days produced no further alteration in any parameter. We conclude that acute potassium depletion in the rat may increase fasting blood glucose concentration, whereas addition of short-term thiazide treatment does not seem to potentiate this effect.
Brørs
O
O
Department of Pharmacology, University of Oslo, Norway.
Lilleng
R
R
Søyland
K
K
Holm
H
H
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D006857:Hydroflumethiazide / Q000633:toxicity*; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D011191:Potassium Deficiency / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism
D001786:Blood Glucose; D006857:Hydroflumethiazide; D012964:Sodium