Metabolism-independent cerebral vasodilation elicited by electrical stimulation of the centromedian-parafascicular complex in rat.
Changes in local cerebral blood flow (1CBF) and local cerebral glucose utilization (1CGU) during electrical stimulation of the centromedian-parafascicular complex in rat have been determined using the autoradiographic [14C]iodoantipyrine and 2-deoxy-[14C]glucose methods. In 40 out of 47 cerebral regions measured, the centromedian-parafascicular complex (CM-Pf) stimulation elicited an increase in 1CBF. The increase in 1CBF was not associated with a rise in cerebral metabolism in 38 regions. Thus, it appears that the activation of CM-Pf neurons or fibers passing through it could play an important role in regulating primary cerebral vasodilation.
Mraovitch
S
S
Laboratoire de Physiologie et Physiopathologie Cérébrovasculaire, INSERM U. 182, C.N.R.S. U.A. 641, Université Paris VII, France.
Seylaz
J
J
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives / Q000032:analysis; D001345:Autoradiography; D001921:Brain / Q000098:blood supply* / Q000378:metabolism / Q000502:physiology; D002560:Cerebrovascular Circulation; D003847:Deoxyglucose / Q000032:analysis; D004558:Electric Stimulation; D005947:Glucose / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013787:Thalamic Nuclei / Q000502:physiology*; D014664:Vasodilation
D003847:Deoxyglucose; D005947:Glucose; D000983:Antipyrine; C008135:iodoantipyrine