Characteristics of inflammation induced by fusarenon-X, a trichothecene mycotoxin from Fusarium species.
Fusarenon-X (F-X) is one of the trichothecene mycotoxins, which have been suggested to induce Fusarium mycotoxicoses. Administration of F-X to experimental animals causes diarrhea, skin irritation, and foot edema. In the present work the properties of F-X-induced inflammation were examined. F-X increased capillary permeability of the abdominal blood vessels in a dose-dependent manner in mice. The F-X-induced increase of the abdominal capillary permeability was not inhibited by 200 mg/kg po of phenylbutazone, 200 mg/kg po of aspirin, 40 mg/kg po of phentolamine, 50 mg/kg po of diphenhydramine, 100 mg/kg po of dibenzyline, 200 mg/kg of hydrocortisone, and 4 mg/kg sc of reserpine. These results suggest that the permeability increment by F-X may not be mediated by serotonin, histamine, norepinephrine, prostaglandins, leukotrienes, and thromboxanes. The increment by F-X also appears to result from histological changes in the capillary blood vessels which are possibly induced by F-X-induced inhibition of protein synthesis, and/or from unidentified inflammatory chemical mediators.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
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Matsuoka
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Kubota
D000005:Abdomen / Q000098:blood supply; D000085:Acetates / Q000633:toxicity; D019342:Acetic Acid; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005670:Fusarium; D007249:Inflammation / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009183:Mycotoxins / Q000633:toxicity*; D012717:Sesquiterpenes / Q000633:toxicity*; D013997:Time Factors; D014255:Trichothecenes / Q000633:toxicity*
D000085:Acetates; D000893:Anti-Inflammatory Agents; D009183:Mycotoxins; D012717:Sesquiterpenes; D014255:Trichothecenes; C002469:fusarenon-X; D019342:Acetic Acid