[The perfused liver. A model for studying hepatic metabolism of drugs: the example of 5-fluorouracil].
Isolated perfused rat liver has been used as a model to study hepatic metabolism of 5-fluorouracil (FUra) at different doses. Results show that FUra concentrations dropped rapidly. At higher doses, however, hepatic enzymes were saturated and FUra no longer disappeared. Nevertheless, substantial doses can be administered without significant hepatic parenchyma destruction.
Centre Oscar-Lambret, Lille, France.
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M
Nguyen-Pamart
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Trupin-Bar
D000818:Animals; D005472:Fluorouracil / Q000008:administration & dosage / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D005472:Fluorouracil
Le foie perfusé. Moyen d'etude du métabolisme hépatique des médicaments: exemple du 5-fluorouracile.