[Molecular biology and mucoviscidosis. Brest experience in 1987].
The gene for cystic fibrosis is located on the long arm of chromosome 7 at 7q31. The close linkage between the disease locus and several DNA markers allowed a study of the DNA restriction polymorphism pattern in 30 Breton families. The frequency of the haplotypes indicated by the probes pJ 3.11, met H and met D was established reaching a 66.6% informativity for the families studies. The complete informativity of a family allows for detection of heterozygous brothers and sisters, uncles and aunts and for antenatal screening on trophoblast biopsies in case of further pregnancies.
Parent
P
P
Département de Pédiatrie et Génétique Médicale, C.H.U. A. Morvan, Brest.
Ferec
C
C
Jehanne
M
M
Chabaud
J J
JJ
Boog
G
G
Saleun
J P
JP
Alix
D
D
D002648:Child; D002897:Chromosomes, Human, Pair 7; D003550:Cystic Fibrosis / Q000235:genetics* / Q000378:metabolism; D005602:France; D006801:Humans; D010375:Pedigree; D011110:Polymorphism, Genetic
Biologie moléculaire et mucoviscidose. Expérience brestoise en 1987.