Evaluation of the potential for interference by dimethyl sulfoxide (DMSO) in drug detection in racing animals.
Dimethyl sulfoxide (DMSO) had been postulated to be a 'masking agent' when used concurrently with therapeutic or prohibited drugs in racing animals. Eight drugs (flunixin, furosemide, caffeine, apomorphine, phenylbutazone, lidocaine, cocaine, and acepromazine maleate) were administered to six horses singly and with concurrent intravenous DMSO. Urine samples were analyzed for the presence of the drugs and/or their metabolites by thin layer chromatography. Direct comparison of thin layer chromatograms of extracts of positive urine samples with and without DMSO verified that DMSO did not interfere with the detection of these drugs.
College of Veterinary Medicine, Oregon State University, Corvallis.
A M
AM
Craig
L L
LL
Blythe
L H
LH
Appell
M L
ML
Slizeski
D000075:Acepromazine / Q000652:urine; D000818:Animals; D001058:Apomorphine / Q000652:urine; D002110:Caffeine / Q000652:urine; D002855:Chromatography, Thin Layer; D003002:Clonixin / Q000031:analogs & derivatives / Q000652:urine; D003042:Cocaine / Q000652:urine; D004121:Dimethyl Sulfoxide / Q000652:urine*; D004347:Drug Interactions; D005260:Female; D005665:Furosemide / Q000652:urine; D006736:Horses / Q000652:urine*; D008012:Lidocaine / Q000652:urine; D004364:Pharmaceutical Preparations / Q000652:urine*; D010653:Phenylbutazone / Q000652:urine
D004364:Pharmaceutical Preparations; C014557:flunixin; D002110:Caffeine; D000075:Acepromazine; D005665:Furosemide; D008012:Lidocaine; D010653:Phenylbutazone; D003042:Cocaine; D001058:Apomorphine; D003002:Clonixin; D004121:Dimethyl Sulfoxide