Specific antibody patterns over a two-year period after rubella immunization with RA 27/3 live attenuated vaccine.
Screening for rubella antibodies was carried out on 1557 schoolgirls aged 9-20. Of seronegative subjects 70% (442/631) were immunized with RA 27/3 rubella vaccine and some of the vaccinees underwent a serological and clinical follow-up over a two year period. Adverse reactions occurred in 27% of vaccinees, usually 1-2 weeks after immunization; late reactions were never observed. The vaccine-induced seroconversion rate evaluated at 4-5 weeks after immunization was 99.7%. Both one and two years after immunization the seropositivity rate of vaccinees was 100%. The maximum geometric mean antibody titre (GMT) was observed at 4-5 weeks after vaccination and a significant GMT decrease was evident on both the following annual controls. Specific antibody patterns in vaccinees were highly variable and in a small number of subjects a remarkable antibody titre decrease was noticed.
Institute of Microbiology, University of Siena, Italy.
P E
PE
Valensin
G M
GM
Rossolini
M G
MG
Cusi
A
A
Zanchi
C
C
Cellesi
A
A
Rossolini
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D005260:Female; D006801:Humans; D007114:Immunization; D012189:Retrospective Studies; D012411:Rubella Vaccine / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology
D000914:Antibodies, Viral; D012411:Rubella Vaccine; D014613:Vaccines, Attenuated