Effects of anorectic agents in rats bearing the Walker-256 tumor.
Since changes of levels of biogenic amines have been found in some brain areas of rats bearing the Walker-256 tumor, a study was performed to assess the actions of three anorectic agents in such animals. The results obtained by dosage of d-amphetamine, fenfluramine or mazindol, on days 5 and 8 after tumor implantation, failed to demonstrate conclusively any predominant modification of a dopaminergic, noradrenergic, or serotonergic system in the anorectic effects of these agents.
Maickel
R P
RP
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907.
Johnson
K
K
Kinney
D R
DR
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001679:Biogenic Amines / Q000378:metabolism*; D002279:Carcinoma 256, Walker / Q000378:metabolism*; D003913:Dextroamphetamine / Q000494:pharmacology; D004435:Eating / Q000187:drug effects; D005277:Fenfluramine / Q000494:pharmacology; D008297:Male; D008454:Mazindol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D001067:Appetite Depressants; D001679:Biogenic Amines; D005277:Fenfluramine; D008454:Mazindol; D003913:Dextroamphetamine