[Studies on antibacterial activity of flomoxef and its distribution to serum and intraperitoneal exudate in surgery].
1. Bacteria detected in cases of acute abdominal ailments encountered in the first department of surgery at Hiroshima university and its related facilities during the recent 4 and a half years were reviewed and the antibacterial activities of flomoxef (FMOX, 6315-S) against these isolates were investigated. As a result, this antibiotic was found to show very high activities against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae and Proteus spp. 2. One gram of FMOX dissolved in 100 ml of physiological saline was administered by intravenous drip infusion during operation and its concentrations in serum and intraperitoneal exudate were determined. The intraperitoneal exudate concentration exceeded the serum concentration in 2 hours after the completion of the drip infusion and, reached high enough concentration to be effective against susceptible bacteria with MICs about 12.5 micrograms/ml. The above results suggested that the new cephem antibiotic FMOX for injection should be sufficiently effective against acute peritonitis.
Yokoyama
T
T
First Department of Surgery, School of Medicine, Hiroshima University.
Kodama
T
T
Takesue
Y
Y
Fujimoto
M
M
Hiyama
E
E
Ichikawa
T
T
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001202:Ascitic Fluid / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D002511:Cephalosporins / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000188:drug therapy* / Q000378:metabolism; D014018:Tissue Distribution
D002511:Cephalosporins; C045693:flomoxef