An experimental study of quinine blindness.
An experimental model of quinine induced blindness is presented. Electrophysiological, angiographical and morphological examinations were made. The occurrence of blindness and any recovery from blindness was dependent upon the dose of quinine taken. As no evidence of acute retinal ischaemia was found it is concluded that quinine is retinotoxic.
Buchanan
T A
TA
Department of Ophthalmology, Royal Victoria Hospital, Belfast, Northern Ireland.
Lyness
R W
RW
Collins
A D
AD
Gardiner
T A
TA
Archer
D B
DB
D000818:Animals; D001766:Blindness / Q000139:chemically induced* / Q000503:physiopathology; D002415:Cats; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D011803:Quinine / Q000633:toxicity*; D012160:Retina / Q000187:drug effects* / Q000648:ultrastructure; D012164:Retinal Diseases / Q000473:pathology
D011803:Quinine