Nifedipine hepatitis.
An 80-year-old woman developed acute hepatitis following her first exposure to nifedipine. This adverse effect was characterised by fever, chills, anorexia, nausea, liver tenderness, hepatitic liver function tests and peripheral blood eosinophilia. On liver biopsy the portal tracts were expanded with a mixed inflammatory cell infiltrate rich in eosinophils. The potential for the occurrence of this adverse effect must increase with the current expansion of indications for the use of nifedipine.
Shaw
D R
DR
Royal Adelaide Hospital, SA.
Misan
G M
GM
Johnson
R D
RD
D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000188:drug therapy*; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D009543:Nifedipine / Q000009:adverse effects* / Q000627:therapeutic use
D009543:Nifedipine