[Parameters of adsorption chromatography. 5. Adsorption parameters of potential pyrimidine-type antimycotics and their correlation with biological activity].
The RF-values of 19 fungicidal pyrimidine derivatives were determined by means of thin-layer chromatography (aluminium oxide layers) in some solvent systems and the relating parameters of adsorption chromatography were calculated. Furthermore the retention times of HPLC were determined. Both of the parameters were correlated with experimentally determined biological values.
Institut für Fortbildung von Arzten und Apothekern, Lehrstuhl für Apothekenwesen, Bratislava.
S
S
Szücsová
Z
Z
Perina
M
M
Sarsúnová
V
V
Vosátka
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000302:isolation & purification* / Q000494:pharmacology; D012997:Solvents
D000935:Antifungal Agents; D011743:Pyrimidines; D012997:Solvents
Parameter der Adsorptionschromatografie. 5. Mitteilung: Adsorptionsparameter potentieller Antimycotica des Pyrimidin-Typs und ihre Korrelation zur biologischen Wirkung.