HPLC assays of noradrenaline and dopamine in CSF samples from drug-free subjects.
An analytical technique based on HPLC and electrochemical detection was developed for assay of free catecholamines in CSF. The mean CSF concentrations of noradrenaline and dopamine were found to be 123 +/- 48 pg/ml and 10 +/- 6 pg/ml, respectively, in 14 drug-free subjects. The monoamine concentrations did not vary with sex or age. No correlation was seen between the noradrenaline and dopamine values. As a preliminary investigation, signs of seasonal variation in the CSF concentration of noradrenaline and dopamine were registered in 4 female subjects.
Department of Psychiatry III, University of Göteborg, Sweden.
M
M
Larsson
A
A
Forsman
J
J
Hallgren
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000134:cerebrospinal fluid*; D012016:Reference Values; D012621:Seasons
D004298:Dopamine; D009638:Norepinephrine