Neuroleptic malignant syndrome and malignant hyperthermia. In vitro comparison with halothane and caffeine contracture tests.
The in vitro halothane and caffeine contracture tests have been performed on muscle tissue from six survivors of the neuroleptic malignant syndrome. The results, which are expressed in accordance with the criteria of the European MH Group, defined five of the subjects as MHN and one patient as MHE. It is concluded that there is no common pathophysiological link between the neuroleptic malignant syndrome and malignant hyperthermia.
Département d'Anesthésie Réanimation Chirurgicale 1, Centre Hospitalier Régional Universitaire, Lille, France.
R
R
Krivosic-Horber
P
P
Adnet
E
E
Guevart
D
D
Theunynck
P
P
Lestavel
D000328:Adult; D000368:Aged; D002110:Caffeine; D004198:Disease Susceptibility; D005260:Female; D006221:Halothane; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis* / Q000503:physiopathology; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis* / Q000503:physiopathology
D002110:Caffeine; D006221:Halothane