Intrathecal injection of autologous leucocytes in glioblastoma: circulatory dynamics within the subarachnoid space and clinical results.
In part I of this report, the CSF circulatory dynamics of autologous leucocytes labelled with indium-111 and injected in the subarachnoid space, in patients operated on for glioblastoma, were studied. In the Part II, a series of 11 patients with recurrent glioblastoma was studied for evaluating the efficacy of intrathecal injection of autologous leucocytes. Six patients previously had radiotherapy. The results in Part I show that after intrathecal injection of autologous leucocytes, these cells follow throughout the subarachnoid space and pass to the systemic blood circulation, showing no evidence of colonization of the tumour or deposit in the tumoural region. The mean survival of the patients studied in Part II was 8 months. Those six patients who received radiotherapy had a mean survival of 11.4 months, and those five who received only intrathecal injection of autologous leucocytes after surgery, had a mean survival of 4 months. This results seem to demonstrate that immunotherapy, as used in this study, is ineffective in patients with glioblastoma.
Department of Neurosurgery, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
J
J
Vaquero
R
R
Martínez
L
L
Barbolla
J
J
de Haro
S
S
de Oya
S
S
Coca
J
J
Ramiro
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000628:therapy*; D002555:Cerebrospinal Fluid / Q000166:cytology; D005260:Female; D005910:Glioma / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007205:Indium Radioisotopes; D007278:Injections, Spinal; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D013346:Subarachnoid Space; D014057:Tomography, X-Ray Computed
D007205:Indium Radioisotopes