[Significance of maternal age in assessing the risk of abortion following prenatal diagnosis in the 1st trimester of pregnancy].
A total of 546 consecutive pregnancies was monitored following CVS to define the abortion risk. In 42 pregnancies an affected fetus was diagnosed and pregnancy subsequently terminated. In the remaining 504 pregnancies the fetal loss rate until 28 weeks of gestation was 26% (5.1%). Fetal loss rate was not influenced by the quantity of collected chorionic tissue. However in mothers with advanced age (greater than or equal to 36 years) the fetal loss rate before 16 weeks is related to the number of catheter insertions and increases from 3% after one insertion to 12.5% after three. It is concluded that maternal age is an additional risk to CVS if more than one catheter insertion is employed.
Department of Obstetrics and Gynecology, Erasmus Universität Rotterdam, Niederlande.
M G
MG
Jahoda
L
L
Pijpers
A
A
Reuss
R P
RP
Vosters
J W
JW
Wladimiroff
E S
ES
Sachs
D000022:Abortion, Spontaneous / Q000209:etiology*; D000328:Adult; D001706:Biopsy; D002824:Chorionic Villi / Q000473:pathology*; D005260:Female; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D011296:Prenatal Diagnosis; D012307:Risk Factors
Die Bedeutung des mütterlichen Alters bei der Beurteilung des Abortrisikos nach pränataler Diagnostik im ersten Schwangerschaftstrimenon.