The immune response to dietary antigens and its influence on disease susceptibility in farm animals.
Transient hypersensitivity reactions of the intestinal immune system to dietary antigens result in increases in enterocyte turnover and villous atrophy. These changes occur in the intestine of the post weaned piglet and precede the proliferation of E. coli and the development of post-weaning diarrhea. We therefore postulated that a transient cell mediated immune response to dietary antigens may increase susceptibility to disease. The interaction of dietary and microbial antigens upon the gut immune system has been investigated in mice and pigs and it has been shown that both exert powerful regulatory effects upon each other.
University of Bristol, Department of Veterinary Medicine, Langford, U.K.
C R
CR
Stokes
B G
BG
Miller
M
M
Bailey
A D
AD
Wilson
F J
FJ
Bourne
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000821:Animal Feed; D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology*; D004064:Digestive System / Q000276:immunology; D004198:Disease Susceptibility; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000276:immunology; D007108:Immune Tolerance; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013025:Glycine max; D013552:Swine / Q000276:immunology*; D013553:Swine Diseases / Q000209:etiology / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000941:Antigens