Effects of DMDP, a tiapamil analogue, on adriamycin efflux in adriamycin-resistant and -sensitive P388 cells.
The calcium channel blockers 'DMDP' [N-3,4-dimethoxyphenethyl)-N-methyl-2-(2-naphthyl-m-dithane-2-prop ylamine)] and verapamil inhibited the active efflux of adriamycin from adriamycin-resistant P388 leukemia cells but had no effect on the drug-sensitive cell line. However, after removal of the calcium channel blockers, DMDP at a low drug concentration caused a much longer inhibition of this efflux pathway than verapamil. This may be attributed to the higher binding affinity of DMDP for receptor sites.
Department of Experimental Pathology, Roswell Park Memorial Institute, Buffalo, N.Y. 14263.
S
S
Radel
E
E
Mayhew
Y M
YM
Rustum
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004317:Doxorubicin / Q000493:pharmacokinetics* / Q000494:pharmacology; D004351:Drug Resistance; D050113:Imino Furanoses; D007941:Leukemia P388 / Q000188:drug therapy* / Q000378:metabolism; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008353:Mannitol / Q000031:analogs & derivatives; D051379:Mice; D011759:Pyrrolidines; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
D000470:Alkaloids; D002121:Calcium Channel Blockers; D050113:Imino Furanoses; D011759:Pyrrolidines; D008353:Mannitol; C043121:2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine; D004317:Doxorubicin; D014700:Verapamil