Anterior pituitary, adrenal, and gonadal hormones during cocaine withdrawal.
Plasma luteinizing hormone (LH), prolactin, testosterone, and cortisol levels were determined in 16 patients after hospital admission for cocaine abuse, during the course of 4 weeks of hospitalization, and before discharge. Hyperprolactinemia was found at admission (mean +/- SD, 27.5 +/- 10.2 ng/ml) and persisted until discharge (mean +/- SD, 28.7 +/- 10.8 ng/ml). Plasma LH, testosterone, and cortisol levels were within normal limits. These findings suggest that persistent elevation of plasma prolactin levels after cocaine withdrawal may reflect a chronic cocaine-induced derangement in neural dopaminergic regulatory systems.
Alcohol and Drug Abuse Research Center, Harvard Medical School/McLean Hospital, Belmont, MA 02178.
J H
JH
Mendelson
S K
SK
Teoh
U
U
Lange
N K
NK
Mello
R
R
Weiss
A
A
Skupny
J
J
Ellingboe
D000328:Adult; D003042:Cocaine; D005260:Female; D006760:Hospitalization; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011388:Prolactin / Q000097:blood*; D019966:Substance-Related Disorders / Q000097:blood* / Q000150:complications; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D003042:Cocaine; D006854:Hydrocortisone