Liver alcohol dehydrogenase: metabolic and energetic aspects.
This paper presents a series of experiments that define the energetics of liver alcohol dehydrogenase and allow the construction of a free energy profile for the ethanol-acetaldehyde interconversion. Because of its broad specificity, we have also performed a series of kinetic studies designed to test the metabolic efficiency and the mode of action of this enzyme in regard to the reversible oxidation of Vitamin A alcohol (retinol). The slower oxidation of Vitamin A aldehyde (retinal) to Vitamin A acid, (retinoic acid) was also investigated.
University of Washington, Department of Chemistry, Seattle 98195.
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D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000818:Animals; D004734:Energy Metabolism; D000431:Ethanol / Q000493:pharmacokinetics; D006736:Horses; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D012172:Retinaldehyde / Q000378:metabolism
D009243:NAD; D000431:Ethanol; D000426:Alcohol Dehydrogenase; D012172:Retinaldehyde