IC50 of trifluoperazine and RMI 12330A for the theophylline and phloretin-induced increase in intestinal D-galactose accumulation.
The effect of trifluoperazine and RMI 12330A on D-Galactose accumulation was studied in isolated rat intestinal mucosa. Both drugs inhibited the theophylline and phloretin-induced increase in tissue sugar accumulation in a concentration-dependent fashion, with IC50 values close to 10(-6) M. These findings suggest that calmodulin might mediate the theophylline and phloretin actions on galactose transport in intact rat ileum.
Alcalde
A I
AI
Departamento de Fisiología Animal, Universidad de Navarra, Pamplona (Spain).
Barcina
Y
Y
Larralde
J
J
Ilundain
A
A
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005690:Galactose / Q000378:metabolism*; D007082:Ileum / Q000378:metabolism; D007097:Imines / Q000494:pharmacology*; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010693:Phloretin / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D013806:Theophylline / Q000037:antagonists & inhibitors; D014268:Trifluoperazine / Q000494:pharmacology*
D007097:Imines; D014268:Trifluoperazine; C014925:RMI 12330A; D013806:Theophylline; D010693:Phloretin; D002118:Calcium; D005690:Galactose