[Bone induction with bone morphogenic protein].
32 experiments in 22 rabbits were performed to investigate the bone regeneration after implantation of lone morphogenetic protein (BMP) in a 6 mm drill-hole of the distal femoral condyle. Two different BMP products have been used. A bone regeneration is to be observed partially at the surface of BMP, but in comparison to the control defects quantitatively insignificant. There is a significant difference in comparison to the bone substitutes Collapat and Pyrost, which proved well (highly significant more bone regeneration) in the same experimental set up. The biology of bone regeneration by; 1. osteogenic transplantation; 2. osteoinduction and 3. osteoconduction ist discussed in detail. According to the own experiments the principle of osteoinduction with BMP is not yet useful for general clinical practice. Probably the osteoinductive effect is disturbed by immunological processes. The extraction of pure "osteogenin" from BMP seems to be important.
Katthagen
B D
BD
Orthopädische Universitätsklinik und Poliklinik Homburg/Saar.
D000818:Animals; D001857:Bone Matrix / Q000502:physiology; D019485:Bone Morphogenetic Proteins; D001861:Bone Regeneration; D010006:Osteoblasts / Q000502:physiology; D011506:Proteins / Q000502:physiology*; D011817:Rabbits; D014945:Wound Healing
D019485:Bone Morphogenetic Proteins; D011506:Proteins
Knocheninduktion mit "Bone morphogenetic protein" (BMP).