Autoradiographic visualization of muscarinic receptors in pulmonary nerves and ganglia.
We investigated autoradiographically the distribution of muscarinic receptors in bovine airways using (-)-[3H]quinuclidinyl benzilate as radioligand. The autoradiographs demonstrated the presence of muscarinic receptors in smooth muscle as well as neuronal muscarinic receptors in pulmonary nerves and ganglia. It is reasonable to believe that the neuronal muscarinic receptors participate in the regulation of neurotransmitter release at the peripheral nerve terminals innervating the bronchial smooth muscle.
Department of Pharmacology, University of Nijmegen, The Netherlands.
C J
CJ
van Koppen
W M
WM
Blankesteijn
A B
AB
Klaassen
J F
JF
Rodrigues de Miranda
A J
AJ
Beld
C A
CA
van Ginneken
D000818:Animals; D001345:Autoradiography; D002417:Cattle; D005724:Ganglia / Q000032:analysis*; D008168:Lung / Q000294:innervation*; D009130:Muscle, Smooth / Q000032:analysis / Q000294:innervation; D011976:Receptors, Muscarinic / Q000032:analysis*
D011976:Receptors, Muscarinic