The treatment of Trypanosoma (Nannomonas) simiae in pigs with diminazene aceturate in combination with a 5-substituted 2-nitroimidazole compound (Ro 15-0216).
Swine Trypanosoma (N.) simiae infections were treated with diminazene aceturate and a 5-substituted 2-nitroimidazole compound (Ro 15-0216). This combination of the two trypanocidal compounds has been successful. Ten mg/kg of diminazene aceturate and 50 mg/kg of Ro 15-0216 or 20 mg/kg of diminazene aceturate and 25 mg/kg of Ro 15-0216 were equally effective, while either drug alone was ineffective. Multiple administration of compound Ro 15-0216 (4 x 20 mg/kg; 3 x 50 mg/kg) at 2 hourly intervals did not cure the animals.
Deutsche Gesellschaft für Technische Zusammenarbeit (GTZ), Veterinary Research Laboratory, Kabete, Kenya.
E
E
Zweygarth
D
D
Röttcher
D000083:Acetanilides / Q000627:therapeutic use*; D000578:Amidines / Q000627:therapeutic use*; D000818:Animals; D004133:Diminazene / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D008297:Male; D051379:Mice; D009593:Nitroimidazoles / Q000627:therapeutic use*; D013552:Swine / Q000469:parasitology; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D014345:Trypanosoma / Q000187:drug effects; D014353:Trypanosomiasis, African / Q000188:drug therapy*
D000083:Acetanilides; D000578:Amidines; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C054646:Ro 15-0216; C003915:diminazene aceturate; D004133:Diminazene