The relationship of various aspects of surgical management to outcome in childhood nonmetastatic osteosarcoma: a report from the Childrens Cancer Study Group.
Recently, much attention has been focused on the role of adjuvant chemotherapy in the treatment of osteosarcoma. Surgery, however, remains the primary modality for the ablation of this disease. In this report, we examine the relationship of various aspects of surgical management of osteosarcoma to prognosis for disease-free survival (DFS) in a randomized study of 234 pediatric patients. Attention is restricted to 166 patients with nonmetastatic disease confined to an extremity and who were randomized to receive one of two chemotherapeutic regimens. No advantage with respect to DFS was attributable to the various aspects of surgical management considered: interval from first symptoms to definitive surgery, surgical sequence, and type of surgery. Only two local recurrences were seen. One occurred in an above knee amputation stump and the other occurred in a patient receiving a tibial allograft. One of these patients died of pulmonary metastases within 6 months of recurrence; the other patient is alive without evidence of disease at last contact after resection of the recurrence followed by chemotherapy.
Makley
J T
JT
Rainbow Babies and Children's Hospital, Cleveland.
Krailo
M
M
Ertel
I J
IJ
Fryer
C J
CJ
Baum
E S
ES
Weetman
R M
RM
Yunis
E J
EJ
Bleyer
W A
WA
Hammond
G D
GD
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000601:surgery*; D002648:Child; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005266:Femoral Neoplasms / Q000601:surgery; D006801:Humans; D006811:Humerus / Q000601:surgery; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D012516:Osteosarcoma / Q000188:drug therapy / Q000556:secondary / Q000601:surgery*; D010386:Pelvic Neoplasms / Q000556:secondary; D011379:Prognosis; D011884:Radius / Q000601:surgery; D011897:Random Allocation; D013977:Tibia / Q000601:surgery; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D008727:Methotrexate