[Filler-controlled release from suspension matrices (laminates)].
The release from a matrix (polyethylenmineral oilgel, Plastibase) with drug (bupranolol) in suspension can be controlled by a controlling layer of the same material which is saturated with the drug. Thus, after a burst period zero order release is reached from the laminate, before square root t-kinetics predominate. The duration of constant release may be extended with fillers in the controlling layer (glass beads, d less than 20 microns). Increasing the thickness of the controlling layer increases both duration of constant release and time to reach it, the latter to a lower extent.
Institut für Pharmazeutische Technologie, Universität Düsseldorf, BRD.
B C
BC
Lippold
P
P
Kurka
D002046:Bupranolol / Q000008:administration & dosage; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D005079:Excipients; D013535:Suspensions; D013997:Time Factors
D003692:Delayed-Action Preparations; D005079:Excipients; D013535:Suspensions; D002046:Bupranolol
Füllstoffgesteuerte Freisetzung aus Suspensionsmatrices (Laminaten).