Secondary metabolites from Fusarium. Two new modified trichothecenes from Fusarium sporotrichioides MC-72083.
Two new, relatively non-toxic, secondary metabolites characterized as 8 alpha- and 8 beta-hydroxysambucoin [1] and [2], isolated from the toxigenic fungus Fusarium sporotrichioides MC-72083 are reported. The structural assignments were established by spectral data with 1H-nmr studies (COSY, dnOes) playing a key role in establishing the stereochemistry in 1 and 2. The isolation of 14 known trichothecenes produced by this fungus is also discussed.
Department of Chemistry, University of Missouri, Columbia 65211.
D G
DG
Corley
G E
GE
Rottinghaus
M S
MS
Tempesta
D000818:Animals; D002642:Chick Embryo; D005670:Fusarium / Q000032:analysis*; D007928:Lethal Dose 50; D013058:Mass Spectrometry; D012717:Sesquiterpenes / Q000378:metabolism*; D014255:Trichothecenes / Q000378:metabolism* / Q000633:toxicity
D012717:Sesquiterpenes; D014255:Trichothecenes