Genetics of stomach and ocular alcohol dehydrogenase and aldehyde dehydrogenase in the mouse.
Activity variants of the stomach and ocular isozyme of aldehyde dehydrogenase (AHD-4) were observed among inbred strains of mice. The phenotypes were inherited in a normal mendelian fashion, with two alleles showing codominant expression at a single locus (Ahd-4). Linkage data indicated that Ahd-4 is localized on chromosome 11 near Hba (alpha hemoglobin locus), and segregated independently of Adh-3, encoding the stomach and ocular isozyme of alcohol dehydrogenase (ADH-C2).
Holmes
R S
RS
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78284.
Popp
R A
RA
VandeBerg
J L
JL
D000426:Alcohol Dehydrogenase / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000818:Animals; D005123:Eye / Q000201:enzymology*; D005260:Female; D007527:Isoenzymes / Q000235:genetics*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D013270:Stomach / Q000201:enzymology*
D007527:Isoenzymes; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase