[Genetic factors in the development of bronchial cancer. Apropos of a pair of identical twins].
An anaplastic bronchial cancer was observed to occur simultaneously in identical twin brothers, with a rapidly fatal outcome. This led to authors to appraise the prevalence of such cases and to study the role of genetic factors in the determining bronchial cancer. A review of the literature has not revealed an identical case, on the other hand 4 twin pairs suffered from a bronchial cancer with a different histology (3 epidermoid and 1 bronchoalveolar) were reported. Familial cases of bronchial cancer were also recorded. The authors go on to allude to the intervention of genetic factors in the defense mechanisms of the lung: mucociliary clearance, immunological defense and the role of aryl hydrocarbon hydroxylase. The precise identification of these factors remains difficult on account of their interaction with environmental factors.
Service de Médecine Interne, Hôpital Raymond-Poincaré, Garches.
J M
JM
Nores
J
J
Dalayeun
J
J
Chebat
P
P
Dieudonne
A
A
Nenna
D001984:Bronchial Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000628:therapy; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000235:genetics* / Q000628:therapy; D003131:Combined Modality Therapy; D004200:Diseases in Twins / Q000235:genetics*; D006801:Humans; D008297:Male; D011859:Radiography; D014427:Twins; D014430:Twins, Monozygotic
Facteurs génétiques dans le déterminisme du cancer bronchique. A propos d'une paire de jumeaux univitellins.