Hyperhydration with glycerol solutions.
Glycerol was tested as an agent to promote hyperhydration of male and female subjects. Series I experiments involved ingesting 0.5, 1.0, or 1.5 g glycerol/kg body wt and within 40 min drinking 0.1% NaCl, 21.4 ml/kg. In series II, 1.0 g glycerol/kg body wt was ingested at time 0, and 25.7 ml/kg of 0.1% NaCl was ingested over a 3.5-h period. Experiments were of 4-h duration and included controls without glycerol as each subject served as his/her control. Blood samples were taken at 40- or 60-min intervals for hemoglobin (Hb), hematocrit (Hct), plasma osmolality, glycerol, and multiple blood chemistry analyses. Urine was collected at 60-min intervals. Glycerol ingestion increased plasma osmolality for 2 h and reduced the total 4-h urine volume. There were no significant changes in Hb or Hct as a result of the glycerol or excess fluid intake. This study demonstrates that glycerol plus excess fluid intake can produce hyperhydration for at least 4 h.
Riedesel
M L
ML
Department of Biology, University of New Mexico, Albuquerque 87131.
Allen
D Y
DY
Peake
G T
GT
Al-Qattan
K
K
D000293:Adolescent; D000328:Adult; D001834:Body Water / Q000378:metabolism*; D003681:Dehydration / Q000517:prevention & control*; D005260:Female; D005440:Fluid Therapy / Q000379:methods; D005990:Glycerol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D009994:Osmolar Concentration; D011188:Potassium / Q000652:urine; D014556:Urine; D014882:Water-Electrolyte Balance
D006454:Hemoglobins; D005990:Glycerol; D011188:Potassium