Differences between early and late-onset Alzheimer's disease.
Alzheimer's disease of early onset versus that of late onset represent different syndromes, with distinct neuropathologies. Patients with early onset disease exhibit a more severe and more widespread loss of neurons from cortical and sub-cortical regions and the neurochemical changes involve not only the cholinergic system, but also neurons containing GABA, somatostatin and norepinephrine.
Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories Terlings Park, Harlow, England.
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Iversen
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002452:Cell Count; D006801:Humans; D009474:Neurons / Q000473:pathology*