The stability of 5,6-dihydrofluorouracil in plasma and the consequences for its analysis.
This study shows that 5,6-dihydrofluorouracil kept in plasma at room temperature deteriorates in time. Preservation is gained by low temperature and low pH of plasma samples. Therefore, plasma samples should be buffered and frozen immediately after being obtained, and thawing should proceed to 5 degrees C only.
Department of Pharmacology, University of Leiden, The Netherlands.
N
N
van den Bosch
O
O
Driessen
E A
EA
van der Velde
C
C
Erkelens
D004355:Drug Stability; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000097:blood; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D013048:Specimen Handling; D013696:Temperature
C019389:5-fluorodihydrouracil; D005472:Fluorouracil