[Locoregional chemotherapy of liver metastases of colorectal cancer].
Intraarterial regional chemotherapy for non-resectable, isolated colorectal metastases to the liver was performed in 121 patients via implantable pumps or infuse-a-ports. FUDR alone or in combination with 5-FU and Mitomycin C was administered in different modalities. Partial response rate ranged between 35 and 71%. Median survival since starting chemotherapy was so far 8-16 months. Extrahepatic relapse occurred in 45%, technical complications in 23% (pump) and 46% (infuse a port). Local toxic side effects strongly depended on drug dosage and application modus. These results corresponded with those of 647 German collective cases and 490 cases from American literature.
Johann-Wolfgang Goethe-Universität, Klinik für Allgemeinchirurgie, Frankfurt.
A
A
Encke
C
C
Hottenrott
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M
Lorenz
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000188:drug therapy*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D011379:Prognosis; D012004:Rectal Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents
Locoregionäre Chemotherapie von Lebermetastasen colorectaler Carcinome.