Amiodarone-induced hepatic phospholipidosis: a morphological alteration independent of pseudoalcoholic liver disease.
In order to study the relationship between amiodarone-induced hepatic phospholipidosis and liver disease, liver biopsies obtained from 13 patients treated with amiodarone for 4 months to 15 years were investigated by light and electron microscopy. Light microscopy showed pseudoalcoholic liver lesions that were probably related to amiodarone in four cases, various alterations (i.e. cirrhosis, three cases; steatosis and fibrosis, two cases; chronic venous congestion, one case; acute hepatitis, one case) that could be explained by another cause than amiodarone in seven cases and normal liver in two cases. In all cases, electron microscopy showed intralysosomal myelin figures suggestive of phospholipidosis. These myelin figures were associated with intralysosomal electron-dense deposits. In the four cases in which analysis by electron microprobe was performed, it demonstrated large amounts of iodine in the electron-dense deposit-containing lysosomes, indicating the accumulation of amiodarone. These results show that hepatic phospholipidosis is constantly observed in amiodarone-treated patients, whether or not pseudoalcoholic liver lesions are present. This phospholipidosis, which could be only a morphological marker of intrahepatic accumulation of the drug, should not therefore be considered grounds for attributing liver disease to the drug.
Guigui
B
B
Département de Pathologie Tissulaire et Cellulaire, Hôpital Henri Mondor, Créteil, France.
Perrot
S
S
Berry
J P
JP
Fleury-Feith
J
J
Martin
N
N
Métreau
J M
JM
Dhumeaux
D
D
Zafrani
E S
ES
D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000009:adverse effects* / Q000032:analysis; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury; D004305:Dose-Response Relationship, Drug; D004577:Electron Probe Microanalysis; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008064:Lipidoses / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000032:analysis / Q000187:drug effects / Q000648:ultrastructure; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000378:metabolism*; D013997:Time Factors
D010743:Phospholipids; D000638:Amiodarone