Magnesuria induced by thiazides and the influence of triamterene.
The effects on magnesium excretion of 4 short-term diuretic treatments (methyclothiazide 2 mg either alone or associated with increasing doses of triamterene) were evaluated in 8 normal volunteers and compared to spontaneous variations during placebo administration. The thiazide exerted a small but significant magnesuric effect, which was prevented only by the lowest dose (25 mg) of triamterene. Larger doses had no protective effect on thiazide-induced magnesuria. Independently of their absolute effects on magnesium excretion, all diuretics impaired the normal ability of the kidneys to compensate fully for the expected changes in magnesium reabsorption induced by extracellular volume contraction.
Department of Nephrology-INSERM U 80-CNRS UA 1177, Hopital Edouart-Herriot, Lyon, France.
M
M
Labeeuw
N
N
Pozet
P
P
Zech
A
A
Hadj-Aissa
J
J
Sassard
D000328:Adult; D001581:Benzothiadiazines; D004232:Diuretics; D004347:Drug Interactions; D006801:Humans; D008274:Magnesium / Q000652:urine*; D008297:Male; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects*; D014223:Triamterene / Q000008:administration & dosage / Q000627:therapeutic use*
D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D008274:Magnesium; D014223:Triamterene