Lateral high abdominal ovariopexy: an original surgical technique for protection of the ovaries during curative radiotherapy for Hodgkin's disease.
An original surgical method for gonadal protection in young women given pelvic radiation for Hodgkin's disease is presented. Lateral high ovarian transposition (LHAO) consists of the transposition of the ovaries into the paracolic gutter during staging laparotomy, after disconnecting the gonads from the fallopian tubes by dividing the tubo-ovarian vessels. The technique's effectiveness was assessed by a study using clinical investigation, radioimmunoassay (RIA) determination of sex hormones, and dosimetry; of 18 patients treated, 10 participated in the study. All but one have normal menses and hormone values, and one pregnancy occurred. We also calculated the doses absorbed by the ovaries and proved that, during inverted Y irradiation following LHAO, the ovaries are exposed to nearly one-half the dose they receive after traditional medial transposition. During subtotal nodal irradiation after LHAO, the irradiation dose is higher than after medialisation, but absolute values are minimal and castration is not induced.
Gaetini
A
A
Third Department of Surgery, University of Turin, Italy.
De Simone
M
M
Urgesi
A
A
Levis
A
A
Resegotti
A
A
Ragona
R
R
Anglesio
S
S
D000293:Adolescent; D000328:Adult; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D008597:Menstrual Cycle / Q000528:radiation effects; D010053:Ovary / Q000528:radiation effects / Q000601:surgery*; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000517:prevention & control*