Effects of DFP on unit activity in rat superior colliculus.
The effect of systemically administered diisopropylfluorophosphate (DFP) on the spontaneous firing rate and light-evoked responses of rat superior colliculus neurons was determined from average histograms of single unit and multiunit activity. DFP produced a dose-dependent increase in superior colliculus spontaneous activity, and a decrease in light evoked activity. In many experiments, light evoked responses were completely abolished. The changes in spontaneous activity were reversible over a period of about 5 hours following DFP injection. These results establish the retino-tectal pathway as a major target of DFP toxicity.
Department of Physiology, University of Kansas Medical Center, Kansas City 66103.
P D
PD
Cheney
R J
RJ
Kasser
J
J
Holsapple
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005074:Evoked Potentials, Visual / Q000187:drug effects; D005260:Female; D007531:Isoflurophate / Q000494:pharmacology*; D008027:Light; D008297:Male; D009474:Neurons / Q000187:drug effects*; D011680:Pupil / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013477:Superior Colliculi / Q000187:drug effects*
D007531:Isoflurophate