A rapid prognostic electrophoretic assay for serum lipid conjugates in carcinoma uterine cervix and breast.
The levels of cholesterol and lipid associated sialic acid in sera of patients with carcinoma uterine cervix and breast cancer were determined using agarose electrophoresis and precipitation method. Elevated level of lipid associated sialic acid was found, that was specifically reflected only in LDL and VLDL fractions. In carcinoma uterine cervix patients, cholesterol in low density lipoprotein increased with corresponding decrease in high density lipoprotein and there was no change in total as well as VLDL cholesterol content. But breast cancer patients were found to have higher concentrations of both total and high density lipoprotein cholesterol. A good positive correlation was found between electrophoresis and precipitation methods for the lipoprotein analysis. We recommend electrophoretic method for rapid routine analysis.
Shanmugam
V
V
Department of Microbiology, Cancer Institute, Madras, India.
Nagarajan
B
B
D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology; D002784:Cholesterol / Q000097:blood*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D009367:Neoplasm Staging; D011379:Prognosis; D012016:Reference Values; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000473:pathology
D008074:Lipoproteins; D002784:Cholesterol