Effect of inhalation of xylene on intracranial self-stimulation behavior in rat.
The effect of the inhalation of xylene on intracranial self-stimulation behavior was studied in rats in a flow-through (dynamic) inhalational behavioral chamber. Rats were exposed successively to four graded concentrations (102, 192, 419 and 623 ppm) of xylene vapor during 2-hr sessions on different days. The rate of lever-pressing showed a dose-dependent decrease during exposure to 192, 419 and 623 ppm of xylene. The 4-hr exposure to the smallest concentration (106 ppm) of xylene failed to show any effect on self-stimulation behavior. During a 5-day 2 hr/day exposure, the decrease in response observed on the 1st day was further accentuated with a nadir on the 3rd day; from the 4th day onwards, the depressant effect was attenuated showing the development of tolerance.
Department of Pharmacology, Howard University College of Medicine, Washington, D.C. 20059.
S
S
Wimolwattanapun
T K
TK
Ghosh
S
S
Mookherjee
R L
RL
Copeland
S N
SN
Pradhan
D000280:Administration, Inhalation; D000818:Animals; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012653:Self Stimulation / Q000187:drug effects*; D014992:Xylenes / Q000008:administration & dosage / Q000494:pharmacology*
D014992:Xylenes