[Methods for determining the glomerular filtration rate in experiments with small animals: position report of the Animal Experiment Diagnosis of Kidney Function Study Group of the Society of Nephrology of East Germany].
The methods of the investigation of the glomerular filtration rate (GFR) in the animal experiment on cats and rats used at present are demonstrated as survey and the results of the basic investigations are compared. The values in cats lie between 20 and 30 ml/min/100 g kidney, in rats GFR values are between 0.6 and 1.0 ml/min/100 g body mass and 0.6-0.3 ml/min/1 g kidney. The basic values are essentially influenced by the experimental conditions and determination methods so that only clearance values within the working team concerned are comparable.
Klinik für Innere Medizin, Theodor Brugsch Humboldt-Universität zu Berlin.
I
I
Hagemann
P W
PW
Wüstenberg
D000818:Animals; D002415:Cats; D004195:Disease Models, Animal; D005919:Glomerular Filtration Rate; D007444:Inulin; D009392:Nephrectomy; D011704:Pyelonephritis / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D007444:Inulin
Methoden zur Bestimmung der glomerulären Filtrationsrate (GFR) in Versuchen an Kleintieren: Positionsbericht der Arbeitsgruppe "Tierexperimentelle Nierenfunktionsdiagnostik" der Gesellschaft für Nephrologie der DDR.