Diets rich in fish oil cannot control tumor cell metastasis.
Rats fed diets containing different amounts of polyunsaturated fatty acids either of the n-3 or n-6 type, received cultured, syngeneic mammary tumor (BN472) cells intravenously. Animals were sacrificed 2 weeks after tumor inoculation, and the number of pulmonary tumor foci was counted. No significant differences in the number of metastatic foci were observed between the dietary groups. Prostaglandin measurements in the supernatant of tumor cells cultured in vitro showed that the tumor cells could produce thromboxane A2. Many investigators connected this tumor synthesis capacity with tumor metastatic activity. Yet in our study, diets rich in menhaden oil, with the known capacity to inhibit thromboxane synthesis, could not control tumor metastasis in this particular tumor model.
Kort
W J
WJ
Laboratory for Experimental Surgery, Medical Faculty, Erasmus University, Rotterdam, The Netherlands.
Weijma
I M
IM
Stehmann
T E
TE
Vergroesen
A J
AJ
Westbroek
D L
DL
D000230:Adenocarcinoma / Q000178:diet therapy / Q000556:secondary; D000818:Animals; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009368:Neoplasm Transplantation; D011453:Prostaglandins / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D011914:Rats, Inbred BN
D005395:Fish Oils; D011453:Prostaglandins