Metabolic effects of long-term therapy with muzolimine and chlorthalidone in hypertension.
Previous short-term studies of muzolimine (a diuretic with frusemide-like activity) had shown that it did not induce a significant change in the serum potassium concentration. In the present study sodium and potassium handling and other metabolic variables have been compared during 16 weeks of therapy with muzolimine and chlorthalidone, a thiazide-like diuretic. During muzolimine treatment, plasma and red cell potassium concentrations remained unchanged, while a significant fall in potassium occurred with chlorthalidone. Neither drug affected the activity of sodium-potassium cotransport or sodium-lithium countertransport in red cells in vitro. Muzolimine and chlorthalidone had similar effects on arterial pressure and on the other metabolic variables tested.
Institute of Internal Medicine and Metabolic Diseases, 2nd Medical School, University of Naples, Italy.
F
F
Galletti
P
P
Strazzullo
R
R
Gagliardi
M
M
Cirillo
A
A
Siani
R
R
Iacone
M
M
Mancini
D000328:Adult; D001692:Biological Transport / Q000187:drug effects; D002752:Chlorthalidone / Q000627:therapeutic use*; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008875:Middle Aged; D009156:Muzolimine / Q000627:therapeutic use*; D011188:Potassium / Q000097:blood; D011720:Pyrazoles / Q000627:therapeutic use*; D011897:Random Allocation; D012964:Sodium / Q000097:blood
D011720:Pyrazoles; D009156:Muzolimine; D012964:Sodium; D002752:Chlorthalidone; D011188:Potassium