Failure of oil adjuvants to enhance immunity induced in mice by an inactivated rabbit Pasteurella multocida vaccine.
Mice were immunized with different preparations of a killed whole cell Pasteurella multocida vaccine and challenged with successive tenfold dilutions of the homologous strain. Vaccines adjuvanted with mineral oil did not confer better protection against death than non-adjuvanted suspensions, even when the mice were challenged at 3 months after vaccination. Very good protection was obtained when the non-adjuvanted suspension had been administered twice.
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Okerman
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Devriese
D000276:Adjuvants, Immunologic; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D004655:Emulsions; D007114:Immunization; D051379:Mice; D009821:Oils; D010325:Pasteurella / Q000276:immunology*; D010326:Pasteurella Infections / Q000517:prevention & control*; D011817:Rabbits / Q000276:immunology; D014613:Vaccines, Attenuated / Q000276:immunology
D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D004655:Emulsions; D009821:Oils; D014613:Vaccines, Attenuated