Effects of aging on parathyroid hormone stimulated ionic fluxes in rat parotid cell aggregates.
The effects of aging on parathyroid hormone stimulated calcium and phosphate efflux from isolated rat parotid cell aggregates differed from that of epinephrine stimulated calcium efflux in magnitude, chronology, and ionic dependence. Parathyroid stimulated ionic fluxes were maximal at 1-3 months of age, declined until 12 months and remained constant thereafter. Epinephrine stimulated calcium efflux remained maximal between 3 and 12 months and declined until at least 24 months. Absolute stimulation of calcium efflux over basal levels was maximal at 4-8% while phosphate efflux was 20-30%.
Molecular Physiology and Genetics Section, NIA, Francis Scott Key Medical Center, Baltimore, MD 21224.
M
M
Shiraki
Y
Y
Ishikawa
B J
BJ
Baum
G S
GS
Roth
D000375:Aging; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002449:Cell Aggregation; D004837:Epinephrine / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D010281:Parathyroid Hormone / Q000494:pharmacology*; D010306:Parotid Gland / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*; D010710:Phosphates / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D010281:Parathyroid Hormone; D010710:Phosphates; D002118:Calcium; D004837:Epinephrine