A study of selenate efflux from human placental microvillus membrane vesicles.
Selenate efflux from human placental brush border membrane vesicles was studied using an ion-exchange column assay. Selenate efflux was found to be mediated almost exclusively by a temperature dependent DIDS-sensitive pathway. Chromate markedly inhibited selenate efflux: in contrast medium selenate had no effect. It is concluded that selenate and sulphate share a common pathway for transport across the human placental microvillus membrane.
Department of Human Anatomy, University of Oxford.
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Shennan
D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D001693:Biological Transport, Active / Q000187:drug effects; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008871:Microvilli / Q000378:metabolism; D010920:Placenta / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D064586:Selenic Acid; D012643:Selenium / Q000493:pharmacokinetics*; D018036:Selenium Compounds; D013431:Sulfates / Q000493:pharmacokinetics; D013696:Temperature
D018036:Selenium Compounds; D013431:Sulfates; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; D012643:Selenium; D064586:Selenic Acid; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid