Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence.
The molecular cloning of sequences encoding human submandibular gland (SMG) statherin and a basic histidine-rich peptide is described. The corresponding mRNA's were highly abundant in the human and the Rhesus monkey (Macaca mulatta) SMG, but no homologous message was detectable in the murine SMG. Sequence analysis revealed strong homology between the statherin and basic histidine-rich mRNA's, suggesting their evolution from a common ancestral sequence.
Dickinson
D P
DP
Dept. of Oral Biology, School of Dental Medicine, State University of New York, Buffalo 14214.
Ridall
A L
AL
Levine
M J
MJ
D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D004247:DNA / Q000032:analysis; D005260:Female; D006801:Humans; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis*; D012471:Salivary Proteins and Peptides / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D013363:Submandibular Gland / Q000032:analysis*
D012333:RNA, Messenger; C018149:STATH protein, human; D012471:Salivary Proteins and Peptides; D004247:DNA