Inhibitory effect of prolonged oral administration of cetraxate hydrochloride on experimentally-induced intestinal metaplasia in Wistar rats.
The effect of cetraxate hydrochloride (Neuer) on the induction of intestinal metaplasia by intragastric instillation of 5% NaOH solution was investigated in Wistar rats. Oral administration of cetraxate, beginning 2 days after NaOH treatment, resulted in a significant increase in antral mucosal blood flow and a significant reduction in the incidence and amount of intestinal metaplasia in experimental week 25, but no significant changes in basal acid secretion or antral mucosal pH. On histological examination, goblet cell metaplasia were frequently seen. These results show that the increased gastric blood flow produced by cetraxate hydrochloride may be associated with the suppression of induction of intestinal metaplasias.
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
M
M
Tatsuta
H
H
Yamamura
H
H
Iishi
H
H
Taniguchi
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000473:pathology*; D005755:Gastrins / Q000378:metabolism; D007413:Intestinal Mucosa / Q000098:blood supply / Q000473:pathology*; D008297:Male; D008679:Metaplasia / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D014148:Tranexamic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D003509:Cyclohexanecarboxylic Acids; D005755:Gastrins; C000665:cetraxate; D014148:Tranexamic Acid