Effects of a stable analogue of PGE2 (11-deoxy-13,14-didehydro-16 (S)-methylester methyl PGE2: FCE 20700) on the secretory processes of conjunctival goblet cells of rabbit.
The effects of the instillation of a PGE2-analogue (11-deoxy-13,14-didehydro-16 (S)-methyl PGE2 methylester: FCE 20700) in the conjunctival sac of the rabbit were studied by means of two methods. The former is a clinical study (Dohlman test), the latter is a morphological investigation (semithin sections) on specimens of the conjunctival mucosa. From both methods it was possible to demonstrate that the FCE 20700 instillation enhanced the mucous lacrimal secretion in rabbits.
Department of Ophthalmology, Messina University, Italy.
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D000818:Animals; D002452:Cell Count; D003228:Conjunctiva / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000187:drug effects; D015232:Dinoprostone / Q000031:analogs & derivatives*; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D005088:Exocrine Glands / Q000166:cytology; D008297:Male; D009093:Mucus / Q000378:metabolism; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D011817:Rabbits; D013268:Stimulation, Chemical; D013666:Tears / Q000378:metabolism; D013997:Time Factors
D011459:Prostaglandins E, Synthetic; C040808:FCE 20700; D015232:Dinoprostone