Effects of all-trans retinoic acid on the morphology of human epidermal cells in vitro.
The effects of all-trans retinoic acid on human epidermal cell cultures were studied using ultrastructural techniques. Differentiation and stratification were reduced in retinoic acid treated epidermal cells. Treated cells developed a rounded appearance and seemed to contain more granules and vacuoles than usual. Desmosomes were not found in treated cells.
Konohana
I
I
Department of Medicine (Dermatology), University of Wales College of Medicine, Health Park, Cardiff, UK.
Hashimoto
T
T
Dykes
P J
PJ
Marks
R
R
D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D004817:Epidermis / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D014212:Tretinoin / Q000494:pharmacology*
D014212:Tretinoin