A search for new derivatives of chiral amino alcohols with an antiarrhythmic activity.
Twelve new (R) and (S) Schiff bases and twelve new (R) and (S) 2-benzylamino-1-butanols have been obtained. Pharmacological tests showed a weak antiarrhythmic and hypotensive activity of the screened chiral 2-benzylamino-1-butanols.
Department of Chemical Technology of Drugs, Medical Academy, Kraków, Poland.
M
M
Eckstein
K
K
Tobiasz-Otrebska
D
D
Kadłubowska
B
B
Bartłomowicz
S
S
Kulawiak
B
B
Gawrońska-Szklarz
M
M
Woyke
B
B
Czerny
S
S
Juźwiak
D000200:Action Potentials / Q000187:drug effects; D000605:Amino Alcohols / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D012545:Schiff Bases / Q000138:chemical synthesis / Q000494:pharmacology; D013237:Stereoisomerism
D000605:Amino Alcohols; D000889:Anti-Arrhythmia Agents; D012545:Schiff Bases