[Determination of N-nitroso compounds in the gastric juice for evaluation of the individual nitrosating capacity of the body].
The article deals with a comparison of the results of human body nitrosating ability determination by two methods: (a) nitroso compound (NC) assay in diurnal urine after oral administration of its precursors, and (b) assay of the same in gastric juice after in vitro addition of precursors. The data for the first part of the investigation were obtained from the literature, and for the second one--from the experiments by the authors. Both studies used essentially identical groups of patients, primarily those suffering gastrointestinal pathology. Since the results matched to a considerable degree, it was inferred that (1) gastric juice is a factor of body nitrosating ability, and (2) in vitro determinations of said ability in gastric juice are fully justified. Moreover, the latter procedure is sometimes more practicable, particularly, in view of the marked relationship between nitrosating ability, and, especially, the efficacy of inhibitors of NC endogenous synthesis, on the one hand, and the individual characteristics of the body, on the other.
Dikun
P P
PP
Pavlov
K A
KA
Ermilov
V B
VB
Volkov
D P
DP
Stefanenko
Iu F
IuF
D000632:Aminopyrine / Q000493:pharmacokinetics; D004123:Dimethylamines / Q000493:pharmacokinetics; D005215:Fasting; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000032:analysis* / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008722:Methods; D009025:Morpholines / Q000493:pharmacokinetics; D009566:Nitrates; D009602:Nitrosamines / Q000652:urine; D009603:Nitroso Compounds / Q000032:analysis* / Q000378:metabolism; D011392:Proline; D012977:Sodium Nitrite / Q000493:pharmacokinetics
D004123:Dimethylamines; D009025:Morpholines; D009566:Nitrates; D009602:Nitrosamines; D009603:Nitroso Compounds; D000632:Aminopyrine; C037574:morpholine; D011392:Proline; C034516:dimethylamine; C010259:nitrosoproline; D012977:Sodium Nitrite
Opredelenie N-nitrozosoedineniĭ v zheludochnom soke dlia otsenki individual'noĭ nitroziruiushcheĭ sposobnosti organizma.