Preliminary studies of the effects of bromocriptine on testicular regression and the spring moult in a seasonal breeder, the male blue fox (Alopex lagopus).
Bromocriptine administration in the form of slow-release injections to male blue foxes during March-May abolished the normal spring rise in plasma prolactin concentrations seen in May and June. The spring moult was prevented and the treated animals retained a winter coat of varied quality and maturity until the end of the study in August. Plasma testosterone concentrations fell normally from March until August. Testicular regression was, however, delayed, although there were individual variations in response. Estimation by DNA flow cytometry in early July of the relative numbers of haploid, diploid and tetraploid cells in the testis showed that, in the treated animals, 74-80% of the cells were haploid (maturing germinal cells), 4-6% tetraploid (mainly primary spermatocytes) and the rest diploid cells (somatic cells and the remaining germinal cell types). In the control males, however, no haploid cells were detected and the majority of cells were diploid (93-99%). At castration in August, histological examination revealed various stages of testicular regression in the treated and control animals.
Smith
A J
AJ
Research Farm for Furbearing Animals, Heggedal, Norway.
Mondain-Monval
M
M
Simon
P
P
Andersen Berg
K
K
Clausen
O P
OP
Hofmo
P O
PO
Scholler
R
R
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D005589:Foxes / Q000502:physiology*; D006197:Hair / Q000187:drug effects* / Q000502:physiology; D008297:Male; D011388:Prolactin / Q000097:blood; D012621:Seasons; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000502:physiology*; D013739:Testosterone / Q000097:blood
D001971:Bromocriptine; D013739:Testosterone; D011388:Prolactin