Effects of chronic manipulations of dietary choline on dynamic behavioural situations.
1. The modifications in rat behaviour caused by chronic manipulations of dietary choline were studied in two schedules of operant conditioning. Adult rats were maintained on choline-deficient, low-choline and high-choline enriched diets. 2. In the "periodic conditioning" test, the schedule of reinforcement was changed from a fixed ratio to a fixed interval schedule. In the "reversal" test the contingency for food delivery was switched four times from one lever to the other in a two lever Skinner box. 3. In the "periodic conditioning" test, control and treated groups showed the same reduction of responses/reinforcement from the beginning to the end of trial. The time-course reduction of responses/reinforcement became significant in the high-choline (331 mg/kg/day) and deficient-choline groups earlier than in the low-choline (75 mg/kg/day) enriched and control groups. 4. In the "reversal" test, the low-choline (110 mg/kg/day) enriched diet improved the reinforced responses in the IV reversal; the high-choline (330 mg/kg/day) diet gave a significant impairment of the reinforced responses in the III and IV reversals. The deficient-choline diet caused a reduced number of the total responses and a worsening of the reinforced responses in the II, III and IV reversals.
Institute of Pharmacology and Pharmacognosy, School of Pharmacy, University of Turin, Italy.
A
A
Fundarò
G
G
Garassino
L
L
Molinengo
D000818:Animals; D001921:Brain / Q000187:drug effects; D002794:Choline / Q000008:administration & dosage*; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011950:Receptors, Cholinergic / Q000187:drug effects; D012055:Reinforcement Schedule; D012193:Reversal Learning / Q000187:drug effects
D011950:Receptors, Cholinergic; D002794:Choline