Blood pressure development in SHR and WKY rats: effects of neonatal monosodium glutamate treatment and evidence for transient hypertension in WKY rats.
Neonatal administration of monosodium glutamate (MSG) failed to alter blood pressure (BP) development in either SHR or WKY rats. Hypothalamic disturbance relevant to hypertension in the SHR is not contributed to by neonatal MSG treatment. All normotensive WKY animals show a transient rise in BP corresponding to the time at which BP peaks in SHR.
Hambley
J W
JW
School of Biological and Biomedical Sciences, NSWIT, Sydney, Australia.
Johnston
G A
GA
Rogers
L J
LJ
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D005971:Glutamates / Q000494:pharmacology*; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012727:Sex Characteristics; D012970:Sodium Glutamate / Q000494:pharmacology*; D013997:Time Factors
D005971:Glutamates; D012970:Sodium Glutamate