[Pharmacokinetics and anti-Dicrocoelium activity of thiophanate and its major metabolite in ruminants].
After a single oral dosage of 40 mg thiophanate/kg in cattle, sheep and goats, the parent compound and its main metabolite: ethyl benzimidazol-1H-yl-2-carbamate (EBC) are evidenced in plasma by HPLC analysis for 60 to 72 hours. The rate of metabolic change of thiophanate into EBC is 34% in sheep, 52% in goats and 57% in cattle. At this dosage, thiophanate seems to be effective against Dicrocoelium in sheep. On the contrary, EBC is uneffective at 15 mg/kg while it seems undetectable in plasma at any time.
Delatour
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P
Laboratoire de Biochimie INRA 54.189, Ecole Nationale Vétérinaire de Lyon, France.
Besse
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S
Romdane
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MN
D000818:Animals; D001562:Benzimidazoles / Q000097:blood / Q000378:metabolism*; D002219:Carbamates / Q000493:pharmacokinetics*; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000188:drug therapy / Q000469:parasitology; D004011:Dicrocoeliasis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D006041:Goats / Q000469:parasitology; D012418:Ruminants / Q000097:blood / Q000469:parasitology*; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood / Q000188:drug therapy / Q000469:parasitology; D013875:Thiophanate / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
D001562:Benzimidazoles; D002219:Carbamates; D013875:Thiophanate
Pharmacocinétique et activité dicrocoelicide du thiophanate et de son métabolite majeur chez les ruminants.