[Examination of skeletal muscles of rats after a short-term flight on Cosmos-1667].
Using morphological and histochemical methods, skeletal muscles (soleus, gastrocnemius), quadriceps and biceps muscles) of Wistar-SPF rats flown for 7 days on Cosmos-1667 were investigated. The short-term exposure to microgravity led to muscle atrophy which primarily involved myofibers with a high level of oxidative metabolism and a low level of ATPase activity. The percentage composition of myofibers of different types remained unchanged. The soleus muscle showed the greatest changes which included both atrophic and dystrophic shifts. Muscle atrophy developed together with metabolic changes that resulted in glycogen accumulation and decreased SDH activity. After return to Earth's gravity microcirculation disorders were seen only in the soleus muscle.
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Il'ina-Kakueva
D000818:Animals; D001284:Atrophy; D002196:Capillaries; D008297:Male; D009132:Muscles / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013026:Space Flight; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014893:Weightlessness / Q000009:adverse effects
D013385:Succinate Dehydrogenase
Issledovanie skeletnykh myshts krys posle kratkovremennogo kosmicheskogo poleta na biosputnike "Kosmos-1667".