A novel supersecondary structure in globular proteins comprising the collagen-like helix and beta-turn.
A structure consisting of the polyproline-II or collagen-like helix immediately succeeded by a beta-turn is seen in several synthetic peptides and has been suggested to be the conformational requirement for proline hydroxylation in nascent procollagen. Using a simple algorithm for detecting secondary structures, we have analysed crystal structure data on 40 globular proteins and have found eight examples of the collagen-helix + beta-turn supersecondary structure in 15 proteins that contain the collagen-like helical segments.
Department of Biochemistry, Memorial University of Newfoundland, St John's, Canada.
V S
VS
Ananthanarayanan
K V
KV
Soman
C
C
Ramakrishnan
D000465:Algorithms; D000595:Amino Acid Sequence; D003094:Collagen; D008969:Molecular Sequence Data; D011487:Protein Conformation
D003094:Collagen