[Disseminated neuroblastoma with intracerebral metastasis in a newborn infant].
We report on a newborn with disseminated neuroblastoma, intracerebral metastasis, localized in the right choroid plexus could be visualized by sonography and computed tomography. Despite low dose chemotherapy with adriamycin and cyclophosphamide skin and plexus metastasis showed marked progression. Therefore multiagent chemotherapy (NBL-82-Study) was initiated and further investigations revealed complete regression of the intra- and extracranial metastases and the leftsided adrenal tumor as well. Two years after the end of therapy, the patient is in good condition without signs of relapse. This case report underlines the importance of cranial sonography or computed tomography in disseminated neuroblastoma of young infants in order to detect or exclude intracranial metastases.
Abteilung Kinderheilkunde der Medizinischen Fakultät der RWTH Aachen.
R
R
Mertens
E
E
Mühler
G
G
Heimann
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002551:Cerebral Ventricle Neoplasms / Q000473:pathology / Q000556:secondary*; D002675:Child, Preschool; D002831:Choroid Plexus / Q000473:pathology*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004453:Echoencephalography; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy / Q000473:pathology*; D009447:Neuroblastoma / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014057:Tomography, X-Ray Computed
D004317:Doxorubicin; D003520:Cyclophosphamide
Disseminiertes Neuroblastom mit intrazerebraler Metastase beim Neugeborenen.