[The role of lipid metabolism disorders in the mechanism of the hepatotoxic effects of rubomycin].
The phase character of the changes in the contents of lipids and phospholipids and impairment of the ratio of separate fractions in the liver mitochondria after discontinuation of rubomycin (daunorubicin) administration were studied in the time course of 35 days. The impairments were accompanied by activation of lipid peroxidation. By the end of the experiment (on the 35th day) there was noted a tendency to normalization of the indices studied.
Saprykina
E V
EV
Sal'nik
B Iu
BIu
D000818:Animals; D003630:Daunorubicin / Q000633:toxicity*; D050356:Lipid Metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D008054:Lipid Peroxides; D010743:Phospholipids; D003630:Daunorubicin
Rol' narusheniĭ lipidnogo metabolizma v mekhanizmakh gepatotoksicheskikh éffektov rubomitsina.