Effect of corticosteroids and aminophylline on active E-rosette formation in patients with diabetic retinopathy.
The reactivity of lymphocyte that form active E-rosettes to corticosteroids and aminophylline were examined in diabetic retinopathy patients with normal intraocular pressure. Aminophylline induced a significant activation of active E-rosette formation when compared with normal subjects. Similar results were observed when diabetics' lymphocytes were tested with corticosteroids. These drugs appear to induce an increase of quantity of T11-sheep erythrocyte receptors on T cells, suggesting abnormalities in diabetics' lymphocytes reactivity.
Departamento de Bioquímica e Immunologia, ICB Universidade Federal de Minas Gerais, UFMG Belo Horizonte, Brazil.
L J
LJ
Antunes
C F
CF
Barsante
J A
JA
Nogueira-Machado
D000328:Adult; D000628:Aminophylline / Q000494:pharmacology*; D003930:Diabetic Retinopathy / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008875:Middle Aged; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D012397:Rosette Formation
D000628:Aminophylline; C009935:prednisolone acetate; D011239:Prednisolone