Pharmacodynamics and tolerance of oral sustained release ritodrine.
A new oral sustained release formulation of ritodrine was tested for patient tolerance in this open study. The doses tested were 120 mg/day, 240 mg/day, and 360 mg/day. No objective toxicity was seen at any level. Doses of 120 mg/day and 240 mg/day were well-tolerated. Of the subjects who received the 360 mg/day dose, most tolerated it well.
Johns Hopkins University School of Medicine, Department of Gynecology and Obstetrics, Baltimore, MD 21205.
F R
FR
Witter
T J
TJ
Benedetti
B G
BG
Petty
A M
AM
Feldman
T A
TA
Traill
J
J
Anderson
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D003692:Delayed-Action Preparations; D005260:Female; D006340:Heart Rate, Fetal / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D011247:Pregnancy; D012312:Ritodrine / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D012312:Ritodrine