Non-cardiac creatine kinase-B activity in serum after abdominal aortic bypass surgery.
Serum creatine kinase (CK) and creatine kinase isoenzyme MB (CK-B) were measured and electrocardiogram (ECG) recorded preoperatively and 24, 48 and 72 hours and 7 days after abdominal aortic bypass grafting in ten patients. No ECG abnormality indicating acute myocardial infarction (AMI) appeared and no patient had chest pain. CK-B was below the discrimination value for AMI in all cases preoperatively, but increased significantly after the operation to a maximal median value of 15 (range 5-32) U/l at 48 hours. The time-activity curve of CK paralleled that of CK-B, reaching a maximal median value of 814 (range 289-1972) U/l at 48 hours. On day 7 CK and CK-B had normalized. The CK-B activity relative to CK activity remained below 6% in all patients. Elevated serum CK-B activity should be utilized with caution for the diagnosis of perioperative AMI in patients undergoing aortic bypass grafting.
Medical Department C, Aalborg Hospital, Denmark.
P T
PT
Andersen
L K
LK
Nielsen
J
J
Møller-Petersen
K
K
Egeblad
D000368:Aged; D001012:Aorta, Abdominal / Q000601:surgery*; D001157:Arterial Occlusive Diseases / Q000628:therapy; D001807:Blood Vessel Prosthesis; D003402:Creatine Kinase / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000628:therapy; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000201:enzymology; D011184:Postoperative Period
D007527:Isoenzymes; D003402:Creatine Kinase