Rapidly fatal pneumococcal septicemia in systemic lupus erythematosus.
Streptococcal pneumoniae septicemia was responsible for the deaths of 3 patients with chronic systemic lupus erythematosus. The absence of a spleen likely contributed to sepsis in 2 patients. One patient had been immunized with 14-valent pneumococcal vaccine with a doubling of serum antibody concentrations at one month to all vaccine capsular polysaccharide types except for Types 1 and 12. The patient died 74 months after immunization of pneumococcal Type 1 sepsis.
Van der Straeten
C
C
Arthritis and Rheumatism Branch, National Institutes of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, MD 20892.
Wei
N
N
Rothschild
J
J
Goozh
J L
JL
Klippel
J H
JH
D000328:Adult; D001428:Bacterial Vaccines; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000209:etiology* / Q000517:prevention & control; D022242:Pneumococcal Vaccines; D018805:Sepsis / Q000209:etiology*
D001428:Bacterial Vaccines; D022242:Pneumococcal Vaccines