[Combined chemotherapy of experimental generalized candidiasis].
It was shown that combined use of the polyene antibiotic amphoglucamine (AMG) and 5-fluorocytosine (5-FC), rifampicin, or methacycline was much more efficient in therapy of experimental generalized candidiasis. Combination of AMG with 5-FC or rifampicin proved to be the most favourable. The use of these combinations resulted in a 7-8-fold increase in the average lifespan of experimental animals, markedly increased their survival and lowered contamination of the internal organs with the fungus. Combination of AMG with 5-FC resulted in complete healing of experimental mice by the end of the treatment. Summation of the antifungal action of the drugs provided the required effect with the polyene dose 2 times lower than the therapeutic one.
Potyl'chanskaia
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Araviĭskiĭ
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RA
D000666:Amphotericin B / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D002177:Candidiasis / Q000188:drug therapy* / Q000401:mortality; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005437:Flucytosine / Q000627:therapeutic use; D008690:Methacycline / Q000627:therapeutic use; D051379:Mice; D012293:Rifampin / Q000627:therapeutic use
C023999:amphoglucamine; D000666:Amphotericin B; D005437:Flucytosine; D008690:Methacycline; D012293:Rifampin
Kombinirovannaia khimioterapiia éksperimental'nogo generalizovannogo kandidoza.