[Ontogeny-derived hematopoietic stem cells divide successively producing clones of differentiated hematopoietic cells].
Forty seven individual haemopoietic cell clones bearing unique radiation markers were studied in long-term bone marrow cultures. Throughout cultivation, clones appeared at different times, 1 to 12 weeks after explanation, survived during 1-10 weeks and markedly varied in size. Usually, the number of metaphases characteristic of an individual clone rapidly increased, achieved a maximum and declined. The cells of disappeared clones were never seen again. The experimental results provide further evidence for the model of haemopoiesis by clonal succession. The data obtained are discussed with respect to the functioning of haemopoietic stem cell population.
E I
EI
Deriugina
N I
NI
Drize
G A
GA
Udalov
I L
IL
Chertkov
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D002448:Cell Adhesion / Q000528:radiation effects; D002454:Cell Differentiation / Q000528:radiation effects; D002455:Cell Division / Q000528:radiation effects; D002999:Clone Cells / Q000166:cytology / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005838:Genotype; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000528:radiation effects; D007621:Karyotyping; D051379:Mice; D008815:Mice, Inbred Strains; D013997:Time Factors
Zalozhennye v ontogeneze stvolovye krovetvornye kletki raskhodutsia posledovatel'no, produtsiruia klony differentsirovannykh krovetvornykh kletok.