[Recurrent acute dyskinesia as the sole manifestation of phenytoin poisoning].
A 20 year-old epileptic female patient was admitted because of recurrent dyskinesias of 3 months duration. She was receiving phenobarbital, phenytoin (PHT) and clonazepam. PHT dosage had been increased 4 months earlier. Clinical examination and CT scan gave normal results. PHT plasmatic levels were 42 micrograms/ml on admission and there were no other symptoms of PHT toxicity. PHT-induced dyskinesias usually occur together with severe encephalopathy and/or clinical or paraclinical evidence of basal ganglia damage and/or other evidence of PHT toxicity, none of which were present here.
Service de Neurologie, Hôpital Saint-Antoine, Paris.
E
E
Roullet
P
P
Koskas
F
F
Mahieux
R
R
Marteau
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004409:Dyskinesia, Drug-Induced / Q000097:blood; D005260:Female; D006801:Humans; D010672:Phenytoin / Q000097:blood / Q000506:poisoning*; D012008:Recurrence
D010672:Phenytoin
Dyskinésies aigues récidivantes seules manifestations d'un surdosage en phénytoine.