[The crystallography behavior of carbamazepine under compression pressure].
In the present paper the crystallographic behavior of the carbamazepine modifications I, II and III were studied under various conditions by means of X-ray powder diffraction, IR-spectroscopy and differential-scanning-calorimetry. It was found that the crystal lattice of the carbamazepine modification I is relative stable to the applied pressure forms, whereas modification II under similar conditions undergoes a polymorphic transformation into carbamazepine modification III, the extent of which depends on compression pressure and storage time of the tablets. In the compression samples of carbamazepine modification III neither IR-spectroscopically nor X-ray-diffractionally an influence of the pressure could be found on growing up of the enantiotrophic modification I.
Sektion Pharmazie, Wissenschaftsbereich Pharmazeutische Technologie, Martin-Luther-Universität Halle-Wittenberg.
H
H
Kala
U
U
Haack
U
U
Wenzel
G
G
Zessin
P
P
Pollandt
D002152:Calorimetry, Differential Scanning; D002220:Carbamazepine / Q000032:analysis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D011312:Pressure; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
D002220:Carbamazepine
Zum kristallografischen Verhalten des Carbamazepins unter Pressdruck.