Nasal lesions in rats exposed to hydrogen sulfide for four hours.
Fischer-344 rats were exposed for 4 hours to 0, 14, 280, or 560 mg of hydrogen sulfide.m-3 and killed 1, 18, or 44 hours later. We evaluated the nasal epithelial cells and determined the anatomic distribution of lesions. Inhalation of 560 mg of hydrogen sulfide.m-3 induced necrosis and exfoliation of respiratory and olfactory mucosal cells, but not squamous epithelial cells. The anatomic distribution of lesions was midway along the nasal passages involving nasal and maxillary conchae, but not ethmoidal conchae. Injured respiratory mucosa repaired rapidly, whereas olfactory mucosa continued to exfoliate at 44 hours after exposure.
Animal Sciences Wing, Alberta Environmental Centre, Vegreville, Canada.
A
A
Lopez
M
M
Prior
S
S
Yong
L
L
Lillie
M
M
Lefebvre
D000818:Animals; D004848:Epithelium / Q000187:drug effects; D006862:Hydrogen Sulfide / Q000633:toxicity*; D008297:Male; D009296:Nasal Cavity / Q000187:drug effects; D009297:Nasal Mucosa / Q000187:drug effects* / Q000473:pathology; D009336:Necrosis; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
D006862:Hydrogen Sulfide