Vasopressin-stimulated turnover of phosphatidylinositol in the decentralised superior cervical ganglion of the rat.
Vasopressin (AVP) receptors have been demonstrated in the superior cervical ganglion (SCG) linked to the turnover of phosphatidylinositol (PI). We have investigated the effect of changes in autonomic function on the turnover of PI in the rat SCG in response to AVP and carbachol. Decentralisation of the SCG for 3 days causes a significant decrease in the response to AVP, while the response to carbachol is unaffected. The decrease in response to AVP is still present 21 days after decentralisation. A similar pattern of changes is present in ganglia from the homozygous Brattleboro rat. Pretreatment with reserpine has no effect on the response to AVP. The results suggest that AVP may be involved in ganglionic transmission in the autonomic nervous system, but that full expression of AVP-induced turnover of PI is dependent on an intact preganglionic input.
Medical Unit, Westminster Hospital, Charing Cross and Westminster Medical School, London, U.K.
A M
AM
Horn
S L
SL
Lightman
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001921:Brain / Q000502:physiology; D002217:Carbachol / Q000494:pharmacology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology
D010716:Phosphatidylinositols; D001127:Arginine Vasopressin; D012110:Reserpine; D002217:Carbachol; D002795:Choline O-Acetyltransferase; D009638:Norepinephrine