Possible association of human growth hormone treatment with an occurrence of acute myeloblastic leukemia with an inversion of chromosome 3 in a child of pituitary dwarfism.
An 11-yr-old girl, who had been treated with human growth hormone (h-GH) for 31 months, developed acute myeloblastic leukemia with an inv(3)(q21q26). Since GH has been suggested to influence the genesis of leukemia, and the inversion 3 has been reported only in adult leukemia patients, the GH treatment may have caused the development of leukemia or accelerated the proliferation of the leukemia cells.
Department of Pediatrics, Hakodate-Chuo Hospital, Japan.
M
M
Endo
Y
Y
Kaneko
T
T
Shikano
H
H
Minami
J
J
Chino
D002648:Child; D002871:Chromosome Banding; D007446:Chromosome Inversion; D002893:Chromosomes, Human, Pair 3; D004393:Dwarfism, Pituitary / Q000188:drug therapy*; D005260:Female; D013006:Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology*
D013006:Growth Hormone