Blood and tissue fluid levels of a new non-steroidal anti-inflammatory preparation of nabumetone.
The pharmacokinetic properties of a new non-steroidal anti-inflammatory preparation of nabumetone have been studied in both plasma and extravascular fluids. The skin suction blister technique was used on six healthy volunteers on two separate occasions and gave good, reproducible results. A single oral dose of 1 g nabumetone achieved significant blood and skin suction blister fluid concentrations. The partition index (area under the concentration curve for the skin suction blister/area under the concentration curve for blood) showed that the orally administered drug was well diffused within the body.
Torre
D
D
Division of Infectious Diseases, General Hospital and Foundation E. and S. Macchi, Varese, Italy.
Sampietro
C
C
Maggiolo
F
F
D000284:Administration, Oral; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001768:Blister / Q000378:metabolism; D002074:Butanones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D000077430:Nabumetone; D012867:Skin / Q000378:metabolism*; D013396:Suction; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002074:Butanones; D000077430:Nabumetone