Experimental investigation of preparations for the immunotherapy of staphylococcal infections.
A comparative experimental study was carried out of antigenic staphylococcal preparations developed in the USSR and Czechoslovakia for the immune therapy of chronic staphylococcal infection. The efficiency of the preparations was unequivocally confirmed using the rabbit staphylococcal sepsis model. The immunogenicity of tested strains was shown not to always correlate with their virulence. Preparations obtained by means of aqueous extraction from mildly virulent immunogenic strains exhibited greater protective activity than those prepared from highly virulent strains. The PCA phenomenon did not differ significantly provided the tested preparations were administered at doses which ensured equal protective action.
I. I. Metehnikov Research Institute of Vaccines and Sera, USSR.
N B
NB
Jegorova
F
F
Výmola
V N
VN
Jefremova
E
E
Vrbová
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000302:isolation & purification*; D005069:Evaluation Studies as Topic; D006168:Guinea Pigs; D007114:Immunization; D007167:Immunotherapy; D011817:Rabbits; D013203:Staphylococcal Infections / Q000628:therapy*; D013210:Staphylococcus / Q000276:immunology* / Q000472:pathogenicity; D014774:Virulence
D000942:Antigens, Bacterial