[Effect of protein isolated from soya on the biotransformation of xenobiotics in the rat liver].
Processes of biotransformation of xenobiotics in the rat liver at consumption of rations containing caseine (5, 14 or 18%) or 18% of soya protein isolate (SPI). Consumption of SPI caused a decrease of restored glutathione concentration in the liver, an increase of glutathione reductase and a sharp activation of glutathione peroxidase in the liver cytosole. The equalizing of the amount of sulfur-containing amino acids in the ration with 14% of caseine with their amount in the ration containing 18% of SPI was followed by the equalizing of the liver restored glutathione concentration. The enrichment of SPI ration with 0.35% of L-methionine led to an increase of the liver restored glutathione concentration to the level observed at 18% of caseine. The activity of the liver microsomal uridine diphosphate-glucuronyltransferase raised under the influence of SPI.
Martinchik
A N
AN
Panova
R V
RV
Feoktistova
A I
AI
Bondarev
G I
GI
D000818:Animals; D001711:Biotransformation; D002364:Caseins / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism; D005978:Glutathione / Q000493:pharmacokinetics; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D014674:Plant Proteins, Dietary / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D030262:Soybean Proteins; D013025:Glycine max
D002364:Caseins; D014674:Plant Proteins, Dietary; D030262:Soybean Proteins; D005978:Glutathione
Vliianie belkovogo izoliata iz soi na biotransformatsiiu chuzherodnykh veshchestv v pecheni krys.