Toxicologic and histopathologic studies of Pleurotus ostreatus mushroom in mice.
The edible mushroom Pleurotus ostreatus (with locally reported toxic properties) was identified and collected 1-4 days after raining in the city of Baghdad. It was freshly extracted with distilled water at room temperature. Both oral and intraperitoneal routes were used for acute and subacute toxicity studies on mice. In spite of important toxicologic signs and findings on treated animals, the estimated 24-h LD50 values exceeded 3 g/kg for both routes of administration. However, the 30-day LD50 values were 319 mg/kg for oral and 1143 mg/kg for i.p. administration. Gross examination of the dissected organs revealed marked haemorrhages in the intestine, liver, lung and the kidney. Histopathologic examination revealed significant changes mainly in the liver, which took the form of inflammation and microabscesses. The present results were consistent with clinical findings available after human and animal ingestion of this mushroom in Iraq.
Biological Research Centre, Scientific Research Council, Jadiriyah, Baghdad, Iraq.
I H
IH
Al-Deen
H A
HA
Twaij
A A
AA
Al-Badr
T A
TA
Istarabadi
D000818:Animals; D001487:Basidiomycota; D001522:Behavior, Animal / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009145:Mushroom Poisoning / Q000473:pathology*; D010936:Plant Extracts / Q000633:toxicity*; D011124:Polyporaceae
D010936:Plant Extracts