[Spinal ganglion neurons of rats--a model for the study of the central serotonin receptors].
Application of 5-hydroxytryptamine (5-HT) (3 x 10(-5) M) on the rat lumbar dorsal ganglia (RDG) induced membrane depolarization with increased input resistance in 30% of neurons, hyperpolarization with decreased input resistance in 30% of neurons and mixed responses in 40% of neurons. Methysergide and amitriptyline (10(-6) M) blocked depolarizing but not hyperpolarizing effects of 5-HT. Propranolol (3 x 10(-6) M) was inactive in respect to both 5-HT responses. 5-HT depolarizing responses of RDG neurons were mediated by 5-HT2 receptors activation and decreased membrane potassium conductivity; 5-HT hyperpolarizing responses were mediated by 5-HT1A receptor activation and increased potassium conductivity. RDG neurons seem to be an interesting model for the investigation of central 5-HT receptor mechanism.
I I
II
Abramets
I V
IV
Komissarov
I M
IM
Samoĭlovich
D000818:Animals; D004347:Drug Interactions; D004553:Electric Conductivity; D005727:Ganglia, Spinal / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010477:Perfusion / Q000379:methods; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin
Neĭrony spinal'nykh gangliev krys--model' dlia izucheniia tsentral'nykh serotoninovykh retseptorov.