[Effects of dibasol and levamisole on the microsomal enzyme system].
It was shown that single doses of levamisole (10 mg/kg) and dibasole (50 and 100 mg/kg) suppressed the activity of cytochrome P-450 that was indicated by an increase of hexenal-induced sleep in mice. Administration of dibasole (100 mg/kg) three times was not followed by a significant change in the sleep duration. It was also established that dibasole administered at the concentration of 5 10(-4) M suppressed approximately by 50% the activity of aminopyrindemethylase and benzopyrenmonooxygenase and exerted no influence on methylcholantrene-induced activity of benzpyrenmonooxygenase.
Astashkin
E I
EI
Prikhod'ko
A Z
AZ
Kosheleva
N A
NA
Pautova
I G
IG
Nikolaeva
I S
IS
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism*; D007978:Levamisole / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D012890:Sleep / Q000187:drug effects
D000959:Antihypertensive Agents; D001562:Benzimidazoles; C004453:bendazole; D007978:Levamisole; D003577:Cytochrome P-450 Enzyme System
Izuchenie vliianie lekarstvennykh preparatov dibazola i levamizola na sistemu mikrosomal'nykh fermentov.