A preliminary evaluation of the effect of N-acetyl-aspartyl-glutamate on pollen nasal challenge as measured by rhinomanometry and symptomatology.
The preventive effect of a nasally administered single dose of the dipeptide N-acetyl-aspartyl-glutamate (NAAGA) on pollen-induced early nasal reaction as measured by rhinomanometry and symptomatology was investigated in a double-blind cross-over placebo controlled study in 18 patients with nasal sensitization to grass pollen. Mean nasal airways resistance at 20, 40, and 60 min post challenge was, respectively, 33%, 37% (P = 0.03) and 27% less after NAAGA than after placebo administration in the same patients. In contrast, no significant effect on sneeze count and rhinorrhoea was found.
Service de Physiologie, Hôpital Lariboisière, Paris, France.
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Ghaem
D000293:Adolescent; D000328:Adult; D000403:Airway Resistance; D002648:Child; D004151:Dipeptides / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy* / Q000503:physiopathology
D004151:Dipeptides; C027172:isospaglumic acid