Abortifacient properties of an extract from Sida veronicaefolia.
A fraction from an alcoholic extract of Sida veronicaefolia, previously reported to be a potent oxytocic, was studied for its abortifacient effects in pregnant rats. Oral doses producing the abortifacient effects were greater than or equal to 32 ml/kg when administered from the 15th-17th day of pregnancy. Similar effects were produced by intravenous doses of greater than or equal to 3 ml/kg. At the minimum effective oral dose of 32 ml/kg, those animals that carried the conceptuses to term (40%) had litters with reduced average number/litter and weight. At twice this dose, only 10% delivered and the litters were sickly. The effects of intravenous administration of the extract was similar but more pronounced and included also some unique acute effects.
Lutterodt
G D
GD
Department of Pharmacology, University of Science and Technology, Kumasi, Ghana.
D000019:Abortifacient Agents; D000818:Animals; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005327:Fetal Resorption / Q000139:chemically induced; D010121:Oxytocin / Q000494:pharmacology; D010936:Plant Extracts / Q000633:toxicity*; D010946:Plants, Medicinal; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D000019:Abortifacient Agents; D010936:Plant Extracts; D010121:Oxytocin