[A preclinical study on the safety of a new antialcoholic drug inmecarb].
A preclinical study on safety of a new antialcoholic drug inmecarb was carried out on three species of experimental animals (rats, guinea pigs, dogs) receiving the drug at different doses including a subtoxic one (1/5 of LD50) for 6 months. The authors concluded that on the basis of a relatively low toxicity and the absence of specific toxicity and long-term side effects the drug may be recommended for clinical use as an antialcoholic agent.
Liubimov
B I
BI
Smol'nikova
N m
Nm
Iavorskii
A N
AN
Strekalova
S N
SN
Boiko
S S
SS
D000427:Alcohol Deterrents / Q000633:toxicity*; D000818:Animals; D001593:Benzyl Compounds / Q000633:toxicity*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007211:Indoles / Q000633:toxicity*; D008099:Liver / Q000187:drug effects; D008297:Male; D009152:Mutagenicity Tests; D051381:Rats; D011919:Rats, Inbred Strains
D000427:Alcohol Deterrents; D001593:Benzyl Compounds; D007211:Indoles; C055071:inmecarb
Doklinicheskoe issledovanie bezopasnosti novogo protivoalkogol'nogo preparata inmekarba.