An exact test for Hardy-Weinberg and multiple alleles.
Algorithms for generating the exact distribution of a finite sample drawn from a population in Hardy-Weinberg equilibrium are given for multiple alleles. The finite sampling distribution is derived analogously to Fisher's 2 X 2 exact distribution and is equivalent to Levene's conditional finite sampling distribution for Hardy-Weinberg populations. The algorithms presented are fast computationally and allow for quick alternatives to standard methods requiring corrections and approximations. Computation time is on the order of a few seconds for three-allele examples and up to 2 minutes for four-allele examples on an IBM 3081 machine.
Louis
E J
EJ
Department of Genetics, University of California, Berkeley 94720.
Dempster
E R
ER
D000465:Algorithms; D000483:Alleles; D001699:Biometry; D008957:Models, Genetic