[Involvement of the growth hormone in rapid increases of the potassium concentration of the serum].
As a rule, the infusion of arginine hydrochloride is followed by an increase in serum potassium. The investigation is concerned with the short-term effect of growth hormone, which can be stimulated by arginine (0.6 g/kg body weight), on potassium concentrations in rats and patients with cerebral death. The administration of human somatotropin causes a significant rise in potassium concentrations in patients with cerebral death (0.4 IU/kg body weight) and in rats (4.0 IU/kg body weight). In comparison, the infusion of arginine hydrochloride will produce only a slight increase in serum potassium in both hypophysectomized rats and patients after cerebral death. Four of the ten animals even exhibited decreases in serum potassium content. Investigations of the cationic property of arginine are used to interpret the potassium increases in the extracellular space. The transport of amino acids through the cell membrane, which can be affected by somatotropin, is put forward as a further explanation. All findings are based on measurements carried out 10-30 min after termination of the infusion.
Abteilung für Anaesthesiologie, Krankenhaus Merheim, Stadt Köln.
M
M
Doehn
C G
CG
Schulze
E
E
Jungck
R
R
Stuttmann
D000758:Anesthesia; D000818:Animals; D001120:Arginine / Q000494:pharmacology; D001926:Brain Death; D013006:Growth Hormone / Q000502:physiology*; D006801:Humans; D007016:Hypophysectomy; D008297:Male; D011188:Potassium / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D013006:Growth Hormone; D001120:Arginine; D011188:Potassium
Die Beteiligung des Wachstumshormons an raschen Anstiegen der Kalium-Konzentration im Serum.