[Metabolic activation of chemical carcinogens by rat tissues in the perinatal period].
Metabolic activation of procarcinogenic 2-acetyl-amino-fluorene, benzo(a)pyrene, aflatoxin B1 and N-nitrosodimethylamine by various tissues of embryonal and newborn rats was studied with the Salmonella/microsome assay. Bioactivation by fetal tissues was shown to be significantly lower than with newborn rat tissues. When aroclor was given to pregnant females a decrease in metabolic activation was observed. This phenomenon was interpreted as a paradoxical effect. Treatment with aroclor of newborns led to a significant increase in biotransformation of all the compounds tested in the liver and after benzo(a)pyrene--in the kidney, and N-nitrosodimethylamine--in the lung.
Mizgirev
I V
IV
Aleksandrov
V A
VA
Maĭorova
I G
IG
Khudoleĭ
V V
VV
D000818:Animals; D000831:Animals, Newborn; D001711:Biotransformation / Q000187:drug effects; D002273:Carcinogens / Q000493:pharmacokinetics* / Q000633:toxicity; D005260:Female; D005333:Fetus; D009152:Mutagenicity Tests / Q000379:methods; D011247:Pregnancy; D051381:Rats; D014018:Tissue Distribution / Q000187:drug effects
D002273:Carcinogens
Metabolicheskaia aktivatsiia khimicheskikh kantserogenov tkaniami krys v perinatal'nom periode.