Diaphragm weakness in Charcot-Marie-Tooth disease.
Two patients are described with Charcot-Marie-Tooth disease and chronic peripheral neuropathy. Both had dyspnoea, orthopnoea, and evidence of severe diaphragm weakness. Expiratory muscle function was well preserved and abnormalities of gas exchange during sleep were only minor.
Laroche
C M
CM
Brompton Hospital, London.
Carroll
N
N
Moxham
J
J
Stanley
N N
NN
Evans
R J
RJ
Green
M
M
D002607:Charcot-Marie-Tooth Disease / Q000503:physiopathology*; D003964:Diaphragm / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009134:Muscular Atrophy, Spinal / Q000503:physiopathology*; D012129:Respiratory Function Tests