4-Methoxybenzyloxycarbonyl amino acids in solid phase peptide synthesis.
Moz-amino acids were used in solid-phase synthesis of Leu-Ala-Gly-Val and thymosin alpha 1. It was found that the Moz-group can be removed rapidly and completely with 5-10% TFA in CH2Cl2. Some advantages of utilizing Moz-amino acids over Boc-amino acids in solid phase peptide synthesis are demonstrated.
Wang
S S
SS
Alpha 1 Biomedicals, Inc., Foster City, California.
Chen
S T
ST
Wang
K T
KT
Merrifield
R B
RB
D002851:Chromatography, High Pressure Liquid; D010455:Peptides / Q000138:chemical synthesis*; D000077596:Thymalfasin; D013947:Thymosin / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D010455:Peptides; D013947:Thymosin; D000077596:Thymalfasin