Trypsin-inhibitory activity of ovalbumin preparations is due to ovomucoid.
Based on the amino-acid sequence it has been proposed that ovalbumin is a proteinase inhibitor. The inhibitory activity against trypsin, chymotrypsin, pancreatic elastase, plasmin, thrombin and pancreatic kallikrein was tested, but none of these proteinases were inhibited by ovalbumin. A commercial preparation of ovalbumin contained an impurity with trypsin inhibitory activity. This impurity was probably ovomucoid.
Department of Clinical Chemistry, Frederiksberg Hospital, Denmark.
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D000818:Animals; D002417:Cattle; D004527:Egg Proteins / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel; D010047:Ovalbumin / Q000494:pharmacology*; D010059:Ovomucin / Q000494:pharmacology*; D010179:Pancreas / Q000201:enzymology; D013552:Swine; D014361:Trypsin Inhibitors
D004527:Egg Proteins; D014361:Trypsin Inhibitors; D010059:Ovomucin; D010047:Ovalbumin