In vitro metabolic study of EGYT-3615 using rat liver microsomes.
In vitro metabolism of EGYT-3615, a prospective new antidepressant was studied by using rat liver microsomes. The metabolite (M) found in earlier in vivo studies was unanimously found to be the product of a microsomal enzymatic process. The Michaelis-Menten constant of the reaction was calculated.
Lengyel
J
J
Department of Pharmacodynamics, Semmelweis University of Medicine, EGIS Pharmaceutical Works, Budapest, Hungary.
Szüts
T
T
Fekete
M
M
Magyar
K
K
D000818:Animals; D000928:Antidepressive Agents / Q000493:pharmacokinetics*; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000493:pharmacokinetics*; D008862:Microsomes, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D013997:Time Factors
D000928:Antidepressive Agents; D007546:Isoquinolines; C054715:EGYT 3615