Effects of DMDP, a tiapamil analogue, on adriamycin efflux in adriamycin-resistant and -sensitive P388 cells.
The calcium channel blockers 'DMDP' [N-3,4-dimethoxyphenethyl)-N-methyl-2-(2-naphthyl-m-dithane-2-prop ylamine)] and verapamil inhibited the active efflux of adriamycin from adriamycin-resistant P388 leukemia cells but had no effect on the drug-sensitive cell line. However, after removal of the calcium channel blockers, DMDP at a low drug concentration caused a much longer inhibition of this efflux pathway than verapamil. This may be attributed to the higher binding affinity of DMDP for receptor sites.
Radel
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Department of Experimental Pathology, Roswell Park Memorial Institute, Buffalo, N.Y. 14263.
Mayhew
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Rustum
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D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004317:Doxorubicin / Q000493:pharmacokinetics* / Q000494:pharmacology; D004351:Drug Resistance; D050113:Imino Furanoses; D007941:Leukemia P388 / Q000188:drug therapy* / Q000378:metabolism; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008353:Mannitol / Q000031:analogs & derivatives; D051379:Mice; D011759:Pyrrolidines; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
D000470:Alkaloids; D002121:Calcium Channel Blockers; D050113:Imino Furanoses; D011759:Pyrrolidines; D008353:Mannitol; C043121:2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine; D004317:Doxorubicin; D014700:Verapamil