Transketolase and 2-oxoglutarate dehydrogenase activities in the brain and liver of the developing rat.
Rat brain transketolase showed little change in activity from birth to adulthood, whereas the liver enzyme activity increased in a biphasic way. In both brain and liver, 2-oxoglutarate dehydrogenase activity increased gradually after birth and reached a plateau at 5 weeks of age. A developmental change in thiamin content in the brain was similar to the change in the 2-oxoglutarate dehydrogenase activity, but this was not the case in the liver.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Japan.
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Iwata
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Tonomura
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Matsuda
D000818:Animals; D001921:Brain / Q000201:enzymology*; D007655:Ketoglutarate Dehydrogenase Complex / Q000378:metabolism*; D007658:Ketone Oxidoreductases / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains / Q000254:growth & development*; D013831:Thiamine / Q000502:physiology; D014174:Transketolase / Q000378:metabolism*
D007658:Ketone Oxidoreductases; D007655:Ketoglutarate Dehydrogenase Complex; D014174:Transketolase; D013831:Thiamine