Serum creatine kinase and lactate dehydrogenase during cardiac irradiation.
Thirty patients irradiated to a major part of the heart had serial determinations of serum total creatine kinase (S-CK), creatine kinase subunit B (S-CK-B), total lactate dehydrogenase (S-LD) and lactate dehydrogenase isoenzyme 1 (S-LD-1) activity at the beginning, at the end and 1-4 months after radiotherapy. One patient had an elevated total S-CK activity three months after radiotherapy, but none of the patients had an elevated S-CK-B activity during follow-up. Three patients had elevated serum LD before irradiation, two patients during and two patients after radiotherapy, but only one patient had an elevated S-LD-1 activity, which decreased during irradiation. We conclude that the heart muscle is not injured by cardiac irradiation to such an extent that CK, CK-B, LD and LD-1 activities rise in serum, if moderate doses (39-62 Gy, NSD 1,137-1,775 rets) are delivered to the heart.
Joensuu
H
H
Department of Radiotherapy, Turku University Central Hospital, Finland.
Irjala
K
K
Asola
R
R
D000328:Adult; D000368:Aged; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006321:Heart / Q000528:radiation effects*; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008479:Mediastinal Neoplasms / Q000532:radiotherapy; D008875:Middle Aged
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase