Taurine conjugation of bile acids protects human cells in culture.
The primary trihydroxy bile acid, cholate, both free and conjugated, is nontoxic in cultured human lymphoblastoid cells incubated in vitro. The primary dihydroxy bile acid, chenodeoxycholate, was more toxic at high concentrations than at low concentrations, but conjugation with taurine reversed it. The free secondary bile acids, deoxycholate and lithocholate, corresponding respectively to cholate and chenodeoxycholate, are extremely toxic, the latter more than the former. Conjugation with taurine reversed the toxicity, as did glycine. Neither free taurine nor free glycine added to unconjugated bile acids decreased toxicity.
New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314.
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Gaull
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Wright
D001647:Bile Acids and Salts / Q000378:metabolism* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D013329:Structure-Activity Relationship; D013654:Taurine / Q000378:metabolism* / Q000633:toxicity
D001647:Bile Acids and Salts; D013654:Taurine