[Repeated spontaneous abortion syndrome. Current status of the topic].
In recurrent spontaneous miscarriages, the etiological work-up must seek for an immunological cause when the gynecological work-up, hysterography and parent's caryotypes are normal. In the first part of the article, the problem of the association recurrent miscarriages-anti-prothrombinase antibodies is presented. A review of the literature shows that this antibody would be present in approximately 10 per cent of the cases of recurrent miscarriages. They imply a specific treatment during pregnancy. The immunological work-up may also indicates an abnormal maternal tolerance of the fetus which presents currently a controverted immunological problem. Its treatment requires a stimulation of maternal immunotolerance, of which the methods and results in terms of our experience and the literature are discussed in the second part of the article.
Clinique Obstétricale, Pavillon K, Hôpital Edouard Herriot, Lyon.
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Mellier
D000026:Abortion, Habitual / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D001779:Blood Coagulation Factors / Q000032:analysis*; D005260:Female; D006801:Humans; D011247:Pregnancy
D001779:Blood Coagulation Factors; C028128:antiprothrombinase
Le syndrome des avortements spontanés à répétition. Etat actuel de la question.