Protective effect of acute ethanol administration on endotoxin-induced liver injury.
The effect of acute administration of ethanol on endotoxin-induced liver injury was studied. Biochemical and histological results indicated that ethanol pretreatment protected endotoxin-induced liver injury through the improvement of hepatic blood circulation, which is probably associated with an inhibitory effect of ethanol on platelet functions and coagulation system.
Dept. of Cent. Cli. Lab., School of Med., Univ. of Occupational and Environmental Health, Kita-kyushu City, Japan.
M
M
Arai
F
F
Okuno
Y
Y
Hirano
S
S
Nakano
T
T
Kobayashi
H
H
Ishii
M
M
Tsuchiya
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004731:Endotoxins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004731:Endotoxins; D000431:Ethanol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase