Hyperfiltration due to amino and keto acid supplements of low-protein diets: influence on proteinuria.
In 12 male 5/6 nephrectomized Sprague-Dawley rats we analyzed the influence of commercially available amino/keto acid supplements on proteinuria. The addition of different supplements to an 8% protein diet resulted in an increase of preexisting proteinuria. Keto acids per se do not seem to cause a remarkable degree of proteinuria/hyperfiltration. Our data underline the importance of the protein content of a low-protein diet and the composition of amino/keto acid supplements, as these factors per se can cause hyperfiltration and might accelerate progression of chronic renal failure.
Clinic of Nephrology, University of Heidelberg, Klinikum Mannheim, FRG.
E
E
Meisinger
N
N
Gretz
M
M
Strauch
D000419:Albuminuria / Q000209:etiology; D000601:Amino Acids, Essential / Q000008:administration & dosage*; D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage*; D005527:Food, Fortified; D005919:Glomerular Filtration Rate; D007651:Keto Acids / Q000008:administration & dosage*; D007676:Kidney Failure, Chronic / Q000178:diet therapy*; D008297:Male; D011507:Proteinuria / Q000209:etiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014511:Uremia / Q000178:diet therapy
D000601:Amino Acids, Essential; D004044:Dietary Proteins; D007651:Keto Acids