Cerebrospinal fluid and neuropathological study in Devic's syndrome. Evidence of intrathecal immune activation.
Cerebrospinal fluid (CSF) was studied in 2 cases of Devic's syndrome (DS). In one of these cases autopsy was carried out. The main CSF feature in DS is the association of blood-brain barrier damage and intrathecal IgG synthesis. These findings are in keeping with our neuropathological observation of diffuse central nervous system vasculitis and leptomeningitis. As a whole, our CSF and neuropathological findings in DS are consistently different from those in multiple sclerosis.
Department of Clinical Neurology, University of Genoa, Italy.
A
A
Leonardi
L
L
Arata
M
M
Farinelli
L
L
Cocito
A
A
Schenone
M
M
Tabaton
G L
GL
Mancardi
D000418:Albumins / Q000134:cerebrospinal fluid; D002490:Central Nervous System / Q000473:pathology; D003711:Demyelinating Diseases / Q000134:cerebrospinal fluid*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007525:Isoelectric Focusing; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D009471:Neuromyelitis Optica / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000473:pathology
D000418:Albumins; D007074:Immunoglobulin G