[The antineoplastic antibiotic polypeptide 308 produced by Actinomadura recticatena. Its isolation and physicochemical properties].
A antitumor antibiotic belonging to the group of polypeptide antibiotics containing chromophore was isolated from the culture of Actinomadura recticatena Terekhova, Preobrazhenskaya et Galatenko, 1984, strain 308. Biosynthesis, isolation, physicochemical and biological properties of the antibiotic are described. The results of elemental analysis, the melting point, optical properties, UV, IR and NMR spectra and the data on acid hydrolysis showed that antibiotic 308 was most closely related to antibiotic BBM-928 A.
Fedorova
G B
GB
Brazhnikova
M G
MG
Borisova
V N
VN
Tolstykh
I V
IV
Volkolupova
O P
OP
D000192:Actinomycetales / Q000378:metabolism*; D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000096:biosynthesis* / Q000302:isolation & purification; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009682:Magnetic Resonance Spectroscopy; D010452:Peptide Biosynthesis; D010455:Peptides / Q000032:analysis / Q000302:isolation & purification; D011804:Quinolines / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000903:Antibiotics, Antineoplastic; D010455:Peptides; D011804:Quinolines; C057108:Antibiotic 308
Protivoopukholevyĭ antibiotik-polipeptid 308, produtsiruemyĭ Actinomadura recticatena. Vydelenie i fiziko-khimicheskie svoĭstva.