Feedback control of neuromuscular blockade. A simple system for infusion of atracurium.
A simple system for closed-loop control of neuromuscular blockade is described. It comprises a Datex Relaxograph, a small relay and a syringe pump. The equipment is commercially available and requires no complex custom-built electronics. Atracurium was infused in a semicontinuous manner to 11 patients who underwent general anaesthesia for a variety of surgical procedures. Neuromuscular blockade oscillated within a narrow range around the preset level. The mean rate of infusion of atracurium was 0.5 mg/kg/hour (SD 0.13). The mean recovery time was 25.5 minutes (SD 7.95).
Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford.
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D000328:Adult; D000368:Aged; D001279:Atracurium / Q000008:administration & dosage*; D004576:Electromyography; D004582:Electronics, Medical; D005246:Feedback; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D008297:Male; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000187:drug effects
D001279:Atracurium