Risk of human immunodeficiency virus (HIV) transmission by anti-HIV negative blood. Estimates using the lookback methodology.
We have estimated the risk of transmitting HIV infection from a unit of HIV seronegative blood collected in Los Angeles and Orange Counties, CA from March 1985 through February 1987. Our method consisted of lookback investigations and anti-HIV testing of living recipients of HIV seronegative units donated by persons who later tested HIV seropositive at the time of a subsequent donation. During these investigations we have documented 3 cases of HIV transmission from HIV seronegative blood; using several assumptions, and extrapolating from this data, we have calculated that the risk of HIV transmission from an HIV seronegative unit was 1 in 51,000 to 1 in 102,000 (with a best guess of 1 in 68,000). We believe that our model can be applied in other geographic regions in an ongoing fashion in order to update our estimates of HIV transmission from HIV seronegative blood.
American Red Cross Blood Services, Los Angeles-Orange Counties Region, CA.
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Kleinman
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Secord
D000163:Acquired Immunodeficiency Syndrome / Q000635:transmission*; D006679:HIV Seropositivity / Q000150:complications; D006801:Humans; D012189:Retrospective Studies / Q000379:methods; D012307:Risk Factors