[Genetic factors in the development of bronchial cancer. Apropos of a pair of identical twins].
An anaplastic bronchial cancer was observed to occur simultaneously in identical twin brothers, with a rapidly fatal outcome. This led to authors to appraise the prevalence of such cases and to study the role of genetic factors in the determining bronchial cancer. A review of the literature has not revealed an identical case, on the other hand 4 twin pairs suffered from a bronchial cancer with a different histology (3 epidermoid and 1 bronchoalveolar) were reported. Familial cases of bronchial cancer were also recorded. The authors go on to allude to the intervention of genetic factors in the defense mechanisms of the lung: mucociliary clearance, immunological defense and the role of aryl hydrocarbon hydroxylase. The precise identification of these factors remains difficult on account of their interaction with environmental factors.
Nores
J M
JM
Service de Médecine Interne, Hôpital Raymond-Poincaré, Garches.
Dalayeun
J
J
Chebat
J
J
Dieudonne
P
P
Nenna
A
A
D001984:Bronchial Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000628:therapy; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000235:genetics* / Q000628:therapy; D003131:Combined Modality Therapy; D004200:Diseases in Twins / Q000235:genetics*; D006801:Humans; D008297:Male; D011859:Radiography; D014427:Twins; D014430:Twins, Monozygotic
Facteurs génétiques dans le déterminisme du cancer bronchique. A propos d'une paire de jumeaux univitellins.