Second generation questions about senescent neuron loss.
Coleman and Flood's review emphasizes the emerging consensus about the magnitude and location of senescent neuron loss. The nature of the findings point to the most pressing questions to ask next. These concern the mechanisms of selective neuron death and of compensation for the death, the functional consequences of neuronal shrinkage and loss of neuronal density, and the sources of individual variability in these factors.
Sapolsky
R M
RM
Department of Biological Sciences, Stanford University, CA 94305.
D000375:Aging / Q000473:pathology*; D001921:Brain / Q000473:pathology; D002452:Cell Count; D002470:Cell Survival; D006801:Humans; D009474:Neurons / Q000473:pathology*