The influence of H-2 genetic factors on the development of benign monoclonal gammopathy in ageing H-2 congenic C57BL and BALB mice.
The role of H-2 genetic factors in the development of benign monoclonal gammopathy (BMG) was investigated in six H-2 congenic C57BL and BALB strains (C57BL/10.ScSn and BALB.B: H-2b; B10.D2 and BALB/c: H-2d; B10.BR and BALB.K: H-2k) during ageing. The frequencies of homogeneous immunoglobulins (H-Ig), both single and multiple, in the three C57BL strains were higher than those in the corresponding three BALB strains. No relationship was found with a particular H-2 haplotype. The most frequent H-Ig isotype within the C57BL strains was IgG2a, within BALB.B and BALB.K mice IgG3 and in BALB/c mice IgG1. Categorization of the monoclonal gammopathies (MG) on the basis of their origin showed a single transient monoclonal B-cell proliferation in 2-5% and 3-9% of the C57BL and BALB mice positive for H-Ig, respectively. Multiple myeloma or B-cell lymphoma were found to be responsible for about 1% of the paraproteinaemias in all strains. Persistent, non-progressive MG, most likely BMG, was detected in 70-81% and 39-46% of the C57BL and BALB mice positive for H-Ig, respectively. The remaining 14-24% and 50-58% of the, respectively, C57BL and BALB mice positive for H-Ig could not be evaluated in time. The H-2 haplotypes under investigation were not associated with the onset, occurrence, multiplicity, persistence or isotype of the MG developing in these H-2 congenic C57BL and BALB strains during ageing.
Department of Cell Biology, Immunology and Genetics, Erasmus University, Rotterdam, The Netherlands.
T W
TW
van den Akker
A P
AP
Tio-Gillen
R
R
Benner
C
C
Zurcher
J
J
Radl
D000375:Aging / Q000276:immunology*; D000818:Animals; D005260:Female; D006183:H-2 Antigens / Q000235:genetics*; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007132:Immunoglobulin Isotypes / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000235:genetics / Q000276:immunology* / Q000473:pathology
D006183:H-2 Antigens; D007132:Immunoglobulin Isotypes; D007136:Immunoglobulins