A new technique to protect ovarian function before pelvic irradiation. Heterotopic ovarian autotransplantation.
The authors describe a new technique for the subcutaneous heterotopic transplantation of the ovary before pelvic irradiation to treat Hodgkin's disease. Creation of a cavity to receive the transplant and the use of two surgical teams and the surgical microscope during the operation ensured its successful outcome. The transplanted ovary was followed up clinically and by ultrasound monitoring: ovarian cycles remained regular despite radiotherapy, and follicle growth occurred normally. In comparison to other types of oophoropexy described in the literature, the advantages of this technique included total protection of the ovary from irradiation, and conservation of ovarian function and fertility. One year after the procedure, puncture of the ovarian compartment produced a mature oocyte specimen.
Département d'Hématologie Clinique, Centre Hospitalier Universitaire, Caen France.
M
M
Leporrier
P
P
von Theobald
J L
JL
Roffe
G
G
Muller
D000293:Adolescent; D001132:Arm / Q000601:surgery; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D010053:Ovary / Q000098:blood supply / Q000528:radiation effects / Q000637:transplantation*; D010060:Ovulation; D010386:Pelvic Neoplasms / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000517:prevention & control*; D014182:Transplantation, Autologous