Penetration of sulbactam and ampicillin into cerebrospinal fluid of infants and young children with meningitis.
Infusions of 50 mg of sulbactam per kg per day and 400 mg of ampicillin per kg per day in divided doses to infants and children with bacterial meningitis produced levels in cerebrospinal fluid approximately one-third those in serum. Concentrations in cerebrospinal fluid of 5.5 micrograms of sulbactam per ml and 16.0 micrograms of ampicillin per ml declined within a few days of therapy to 1.9 microgram of sulbactam per ml and 5.2 micrograms of ampicillin per ml.
Central Research Division, Pfizer, Inc., Groton, Connecticut 06340.
G
G
Foulds
T J
TJ
McBride
A K
AK
Knirsch
W J
WJ
Rodriguez
W N
WN
Khan
D000293:Adolescent; D000667:Ampicillin / Q000134:cerebrospinal fluid*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D010539:Permeability; D013407:Sulbactam / Q000134:cerebrospinal fluid*
D000667:Ampicillin; D013407:Sulbactam