Effect of enzyme inducer flumecinolum (Zixoryn) on aminophylline metabolism in rats.
The effect of the enzyme inducer flumecinolum, m-trifluoromethyl-alpha-ethylbenzhydrol (Zixoryn), on aminophylline metabolism was examined in rats. Aminophylline plasma levels were determined by HPLC. Aminophylline T1/2 was 2.85 hours (r = 0.9353) in the pretreated group and 3.75 hours (r = 0.9471) in the untreated control group. Flumecinolum was found to accelerate the elimination of aminophylline and the effect became significant 3.92 hours after the administration of aminophylline.
Szeitz
A
A
Clinical Pharmacology and Pathophysiological Research Unit, National Korányi, Institute for TBC and Pulmonology, Budapest, Hungary.
Huszár
E
E
Herjavecz
I
I
Vértes
K
K
Debreczeni
L A
LA
D000628:Aminophylline / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001559:Benzhydryl Compounds; D000628:Aminophylline; C016914:flumecinol