Influence of drying methods on granule and tablet properties.
Three methods of drying pharmaceutical granules have been investigated using tray, fluidized-bed and intra-red dryers. A comparative study of the dryers' thermal efficiency and drying time and their effects on granule and tablet properties is presented. Fluidized-bed and intra-red dryers were found to have a 2- to 5-fold advantage in thermal efficiency over tray dryers in granule drying with the fluidized bed dryer being the most efficient. The granules dried by these two dryers also produced of better physical properties (quality) than those of tray dryer, in the formulation of tablets of both soluble and insoluble organic medicinal substances.
Femi-Oyewo
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MN
Department of Pharmaceutic, University of Ife, Ile-Ife, Nigeria.
Nasipuri
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RN
D002626:Chemistry, Pharmaceutical; D005079:Excipients; D006244:Hardness; D010316:Particle Size; D011208:Powders; D013607:Tablets
D005079:Excipients; D011208:Powders; D013607:Tablets