Cardiotoxicity testing of organic solvents by coronary artery ligation in closed-chest rats.
The effect in coronary artery occlusion was investigated in closed-chest anesthetized (urethane, pentobarbital, ether) and conscious rats. The parameters measured were: arrhythmia development, heart rate changes and mortality. Lowest mortality rate and less severe arrhythmias were observed in the urethane group. In urethane-anesthetized rats single oral administration of carbon disulphide (8.3 mmol/kg), chloroform (5.7 mmol/kg), trichloroethylene (16.7 mmol/kg) and ethanol (174 mmol/kg), respectively, 1 h prior to coronary occlusion reduced survival rate accompanied by marked influences on arrhythmia development. The coronary occlusion method in closed-chest rats under urethane-anesthesia appears to be a valuable tool for investigating cardiotoxic effects of chemicals.
Institute of Industrial Toxicology, Martin Luther University Halle, German Democratic Republic.
P
P
Hoffmann
D000777:Anesthetics / Q000633:toxicity; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D003327:Coronary Disease / Q000401:mortality / Q000503:physiopathology*; D008297:Male; D009203:Myocardial Infarction / Q000401:mortality; D051381:Rats; D011919:Rats, Inbred Strains; D012997:Solvents / Q000633:toxicity*
D000777:Anesthetics; D012997:Solvents