[Cytogenetic effect of testosterone on rat hepatocytes].
The capacity of testosterone administered in vivo in the form of testosterone propionate (TP), to modify chromosome integrity and a search for certain conditions under which the hormone manifested cytogenetic activity, were determined. TP was administered at a single dose or for 12 days at various doses to random bred albino male rats aged 3-4.5 mos. Single administration of the hormone to animals aged 4-4.5 mos. did not result in an increase in the number of hepatocytes with chromosome aberrations even at a dose exceeding 6-7-fold daily production. However after daily administration for 12 days at a dose exceeding only twice the daily one, TP increased 1.5-fold the number of cells with damaged chromosomes. In animals aged 3-3.5 mos. the same scheme of administration of TP turned out ineffective. The results obtained are under discussion.
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OI
Timchenko
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EN
Antipenko
D000367:Age Factors; D000818:Animals; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000648:ultrastructure*; D008297:Male; D009154:Mutation; D051381:Rats; D013739:Testosterone / Q000031:analogs & derivatives* / Q000633:toxicity; D043343:Testosterone Propionate / Q000031:analogs & derivatives; D013997:Time Factors
D013739:Testosterone; C035458:testosterone 17-phenylpropionate; D043343:Testosterone Propionate
Tsitogeneticheskoe vliianie testosterona na kletki pecheni krys.