[The effect of nonanoyl vanillylamide on the chemically-induced nociception].
The aim of the present investigation was to determine the effects of a single dose and serial doses of nonanoyl vanillylamide (NVA) administered subcutaneously on responses induced by chemical stimuli in the mouse. The treatment with a single subcutaneous injection produced a significant decrease in the number of abdominal contraction responses produced by intraperitoneal injections of phenylbenzoquinone and in the responsive time of licking induced by plantar injection of formalin. The serial subcutaneous administration of NVA caused a dose related antinociceptive effect against a chemical nociceptive stimulus using the phenylbenzoquinone-induced writhing test, while NVA was ineffective against a chemical stimulus, formalin. These results suggest that serial doses of NVA administered peripherally cause different effects in two types of chemically-induced nociception.
Department of Pharmacology, Tohoku College of Pharmacy, Sendai, Japan.
T
T
Fujii
S
S
Sakurada
K
K
Tanno
M
M
Yabuta
T
T
Sasaki
K
K
Yamaguchi
R
R
Andoh
K
K
Kisara
D000700:Analgesics; D000818:Animals; D016227:Benzoquinones; D002211:Capsaicin / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde / Q000037:antagonists & inhibitors; D062385:Hydroxybenzoates / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D010147:Pain Measurement; D011809:Quinones / Q000037:antagonists & inhibitors; D013268:Stimulation, Chemical; D014641:Vanillic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*
D000700:Analgesics; D016227:Benzoquinones; D062385:Hydroxybenzoates; D011809:Quinones; D005557:Formaldehyde; C029322:phenylbenzoquinone; D014641:Vanillic Acid; D002211:Capsaicin; C040937:nonivamide