Synthesis and search for anticonvulsive and hypoglycemic properties of novel 5-benzylidene derivatives of 3-o-chloro- and 3-o-methylbenzoyl-2-thiohydantoin.
14 new benzylidene derivatives of 3-o-chloro- and 3-o-methylbenzoyl-2 thio hydantoin were synthesized. Their chemical structure was confirmed by IR, NMR and mass spectroscopy. Compounds 1-14 were tested for their anticonvulsant and hypoglycemic activity. Their toxicity was low and they showed only weak activity in tests for anticonvulsive and hypoglycemic properties.
Kleinrok
Z
Z
Department of Pharmacology, Medical Academy, Lublin, Poland.
Sermak
W
W
Kozicka
M
M
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D001565:Benzoates / Q000138:chemical synthesis / Q000494:pharmacology; D005260:Female; D006827:Hydantoins / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013055:Spectrophotometry, Infrared; D013867:Thiohydantoins / Q000138:chemical synthesis / Q000494:pharmacology*
D000927:Anticonvulsants; D001565:Benzoates; D006827:Hydantoins; D007004:Hypoglycemic Agents; D013867:Thiohydantoins