Recovery process of tracheal mucosa of guinea pigs exposed to isopropyl alcohol.
The toxicity of isopropyl alcohol (IPA) on the tracheal mucosa was studied experimentally with special reference to the recovery process of the organ. The results showed that 400 ppm IPA has an acute effect on the mucociliary system in the tracheal mucosa, and that recovery from such degeneration can occur in 2 weeks. When functional and morphological damage was induced by a higher level (5500 ppm) of IPA, recovery did not occur in 2 weeks. The conclusion is that the present allowable level of IPA is reasonable from the viewpoint of the effects of short-term exposure to IPA on the tracheal mucosa. In addition, a higher level of IPA exposure has longer-term effects on the tracheal mucosa, and workers exposed to such a higher level of IPA vapor should be given careful otolaryngological follow-up observations.
Department of Otolaryngology, Osaka City University Medical School, Japan.
Y
Y
Ohashi
Y
Y
Nakai
H
H
Ikeoka
H
H
Koshimo
Y
Y
Esaki
S
S
Horiguchi
K
K
Teramoto
H
H
Nakaseko
D000433:1-Propanol / Q000633:toxicity*; D000818:Animals; D002923:Cilia / Q000187:drug effects / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009092:Mucous Membrane / Q000187:drug effects / Q000648:ultrastructure; D014132:Trachea / Q000187:drug effects*
D000433:1-Propanol