Liquid chromatographic optimization of reaction conditions for the synthesis of 2,2-dimethyl-N-benzylmalonamide, a new anticonvulsant.
Reversed-phase liquid chromatographic (RP/LC) procedures are used to optimize the reaction conditions for the large scale preparation of 2,2-dimethyl-N-benzylmalonamide, 1. In acute studies using mice and rats, compound 1 is a very effective anticonvulsant agent. Large quantities of 1 (ca. 300 g) are needed for detailed studies of its chronic effects. LC monitoring of the synthesis of intermediate products and 1 result in the optimum use of reagents, increased product yields, and decreased reaction times.
McMillian
C L
CL
Department of Pharmacal Sciences, School of Pharmacy, Auburn University, Alabama 36849.
DeRuiter
J
J
Clark
C R
CR
D000927:Anticonvulsants / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D008314:Malonates / Q000138:chemical synthesis* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet
D000927:Anticonvulsants; D008314:Malonates; C054876:2,2-dimethyl-n-benzylmalonamide