Inhibition of Dopa decarboxylase by caffeic acid and related compounds: structure-activity relationships.
The inhibition of purified Dopa decarboxylase, has been performed with dihydroxyphenyl derivatives devoided of the NH2 group and unable to form the Schiff base with pyridoxal-5' phosphate. The more efficient inhibition is displayed by caffeic acid and related compounds that present an insaturation in the chain. The relative contribution to the inhibition by the chain and ring structures has been evaluated.
Department of Biochemical Sciences, University La Sapienza, Rome, Italy.
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Rosei
D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D002109:Caffeic Acids / Q000494:pharmacology*; D002934:Cinnamates / Q000494:pharmacology*; D007700:Kinetics; D013329:Structure-Activity Relationship
D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D002109:Caffeic Acids; D002934:Cinnamates