[Electrophysiologic and histologic retinal changes after diethylene glycol administration].
The toxic effect of diethylene glycol on the retina was studied in white New Zealand rabbits. In a three-month study diethylene glycol dissolved in water was administered orally to groups of four rabbits at dose levels of 0 (control) and 4%. The ERG revealed a dose-dependent prolongation of the b-wave and a reduction in the photopic amplitudes of the a- and b-waves. In agreement with the electrophysiological findings the histologic study of the retina showed birefringent crystals predominantly in the inner nuclear cell layer. Oxalate seemed to be a metabolite of diethylene glycol, because aggregations of calcium oxalate crystals were deposited in the kidneys and livers of the animals.
Rossa
V
V
Univ.-Augenklinik Düsseldorf.
Weber
U
U
D000818:Animals; D002129:Calcium Oxalate / Q000378:metabolism; D004596:Electroretinography; D005026:Ethylene Glycols / Q000633:toxicity*; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology
D005026:Ethylene Glycols; D002129:Calcium Oxalate; C013484:diethylene glycol
Elektrophysiologische und histologische Netzhautveränderungen nach Diethylenglykol-Einnahme.