[Analysis of the survival rate in a combined radiation lesion. The evaluation of synergism (or antagonism) in the case of 2 exposures].
The method of the estimation of interaction between two harmful effects based on the statistical survival rate data is discussed. In terms of the competitive risk model, an independent effect was defined as a product of survival functions corresponding to an isolated effect of each injurious factor. The proposed method is based on the comparison between the animals' lifetimes in the case of the isolated effects and the actual survival rates after the combined radiation effect. The comparison of the two alternatives was made by the regression model of Cox adapted for the purposes of this study.
Miasnikova
E M
EM
Iakovlev
A Iu
AIu
Rachev
S G
SG
Komarov
E I
EI
Remizova
I V
IV
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity; D002056:Burns / Q000401:mortality; D008297:Male; D008954:Models, Biological; D011833:Radiation Injuries, Experimental / Q000401:mortality*; D051381:Rats; D011919:Rats, Inbred Strains; D012044:Regression Analysis; D012307:Risk Factors; D014227:Triazines / Q000633:toxicity
D000970:Antineoplastic Agents; D014227:Triazines; C040269:dioxadet
Analiz vyzhivaemosti pri kombinirovannom radiatsionnom porazhenii. Otsenka sinergizma (ili antagonizma) v sluchae dvukh vozdeĭstviĭ.