Fluorescence in situ hybridization and Y ring chromosome.
Investigations by fluorescence in situ hybridization and a Y-specific probe (Y190) of a male patient with a Y ring chromosome, 46,X,r(Y) showed four bright fluorescent spots within the ring. Thus, using this technique, it is possible to suggest that the ring originates from the duplication of the short arms of the Y chromosome.
Paediatric Research Unit, United Medical School, Guy's Hospital, London, UK.
R
R
Kozma
C
C
Fear
M
M
Adinolfi
D000328:Adult; D006801:Humans; D008297:Male; D008856:Microscopy, Fluorescence; D009693:Nucleic Acid Hybridization; D009845:Oligospermia / Q000209:etiology; D012729:Sex Chromosome Aberrations; D014998:Y Chromosome