[Relation between disorders of glucose metabolism, secretion of somatotropic hormone, thyroxine, thyrotropin and hematocrit indices in rats with transplanted hepatomas].
The levels of growth hormone (GH) in the blood of rats with ascite Zajdela hepatoma and hepatoma 27 (H-27) are shown to increase during the tumour growth. Stimulation of the GH secretion is a result of the hypoglycaemic stress. An increase in the blood GH secretion is also observed in the fasting rats. To reveal the predominance of catabolic GH effects over the anabolic ones in the tumour host determination of the molar insulin/GH ratio in the blood is suggested. A direct correlation is found between reduction of this index, glycaemia and the content of liver glycogen. A short-term induced hyperglycaemia evokes a paradoxical reaction in terms of GH secretion. In contrast to control fasting rats, in tumour-bearing animals no correlation between thyrotropin and thyroxine blood concentration could be observed. Anaemia increasing progressively in the course of the tumour growth may be the cause of the above phenomenon.
Shelepov
V P
VP
Pasha-zade
G R
GR
Chekulaev
V A
VA
Shapot
V S
VS
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005215:Fasting; D013006:Growth Hormone / Q000097:blood*; D006400:Hematocrit; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000378:metabolism*; D008297:Male; D051381:Rats; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*
D001786:Blood Glucose; D013972:Thyrotropin; D013006:Growth Hormone; D013974:Thyroxine
Vzaimosviaz' narusheniĭ obmena gliukozy i sekretsii somatotropnogo gormona, tiroksina, tirotropina, pokazatelia gematokrita u krys s perevivnymi gepatomami.