[Effectiveness and tolerance of an active combination of timolol and pilocarpine--a pilot project].
A pilot study was conducted to find out whether it is possible to achieve a further drop in intraocular pressure in eyes with glaucoma, which is about 22 mmHg after treatment with 0.5% timolol, by employing a combination preparation of timolol 0.5% and pilocarpine 2% or timolol 0.5% and pilocarpine 4% respectively, administered as eyedrops. This resulted in an average additional lowering of 1.9 mmHg after 2 hrs and by 2.1 mmHg after 6 hours (TP2) or by 3.0 mmHg after 2 and 3.5 mmHg after 6 and by 2.7 mmHg after 12 hours (TP4), the therapeutically relevant duration of effectivity being 6 (TP2) or 12 (TP4) hours, respectively.
Schnarr
K D
KD
Augenklinik und -poliklinik rechts der Isar der Technischen Universität München.
Merté
H J
HJ
D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D010862:Pilocarpine / Q000008:administration & dosage*; D010865:Pilot Projects; D013999:Timolol / Q000008:administration & dosage*
D010862:Pilocarpine; D013999:Timolol
Wirksamkeit und Verträglichkeit einer Wirkstoffkombination von Timolol und Pilocarpin--Eine Pilotstudie.