A five-way complex translocation in a patient with chronic myelocytic leukemia: t(4;18;13;9;22)(q12;q11.2;q14;q34;q11.2).
A 10-year-old boy with chronic myelocytic leukemia was found to have a new complex Philadelphia translocation. All of the bone marrow cells and the peripheral blood cells had a rearrangement of a five-way translocation. t(4;18;13;9;22)(q12;q11.2;q14;q34;q11.2). The patient eventually died in blast crisis 6 years, 9 months later.
Department of Pediatrics, Kuramaguchi Hospital, Kyoto, Japan.
F
F
Nakajima
M
M
Takagi
K
K
Tsuchiya
S
S
Imashuku
S
S
Arakawa
S
S
Misawa
T
T
Abe
D002648:Child; D002871:Chromosome Banding; D002882:Chromosomes, Human, Pair 13; D002887:Chromosomes, Human, Pair 18; D002892:Chromosomes, Human, Pair 22; D002894:Chromosomes, Human, Pair 4; D002899:Chromosomes, Human, Pair 9; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic
D005819:Genetic Markers