Lymphorrhage localized to the muscle end-plate in myasthenia gravis.
Lymphocytic infiltration of muscle (lymphorrhage) is occasionally observed in myasthenia gravis. We describe a 56-year-old woman with autoimmune myasthenia gravis, whose muscle biopsy specimen demonstrates acute cellular reaction localized to the end-plate region. This observation raises the possibility of a more direct role of the cellular immune system in the pathogenesis of the disease, and provides a morphologic link between the human and the experimental myasthenia gravis.
Department of Neurology, Indiana University School of Medicine, Indianapolis 46202.
R M
RM
Pascuzzi
J F
JF
Campa
D001706:Biopsy; D005260:Female; D006801:Humans; D008196:Lymph / Q000378:metabolism*; D008875:Middle Aged; D009045:Motor Endplate / Q000378:metabolism* / Q000473:pathology; D009132:Muscles / Q000473:pathology; D009157:Myasthenia Gravis / Q000378:metabolism* / Q000473:pathology; D009469:Neuromuscular Junction / Q000378:metabolism*