Effect of diabetes on the enzymes of the cholinergic system of the rat brain.
Choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities were determined in several brain regions of normal and streptozotocin-induced diabetic rats. The diabetic rats exhibited significant increase in ChAT activity (p less than 0.05) in all brain regions studied except for the cortex and the midbrain. Meanwhile, the diabetes condition was associated with significant increase (p less than 0.05) in AChE activity of the bulbus olfactorius, medulla oblongata and cerebellum. These data suggest that uncontrolled diabetes is associated with significant alterations in the brain cholinergic systems.
College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee 32307.
Z Z
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Wahba
K F
KF
Soliman
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D001931:Brain Mapping; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*
D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase