Trisomy 11 in myelodysplasia.
A case of pancytopenia with dysplastic changes in the bone marrow with trisomy 11 (+11) as the sole karyotypic anomaly in an adult male is described. The literature on +11, both as a primary (14 cases) and secondary (55 cases) cytogenetic event in hematologic disorders, is summarized and the findings are discussed. There is the possibility that +11 is a nonrandom chromosomal anomaly in some myelodysplastic disorders.
Genetics Center Southwest Biomedical Research Institute, Scottsdale, AZ 85345.
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R
Morgan
M H
MH
Greene
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Sandberg
D000368:Aged; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D014314:Trisomy
D005819:Genetic Markers