Determination of terbutaline sulfate in dosage forms by liquid chromatography with electrochemical detection.
A liquid chromatographic method with electrochemical detection has been developed for the determination of terbutaline sulfate in dosage forms. A cyanopropyl bonded-phase column is used with a mobile phase consisting of methanol-0.1 M monobasic potassium phosphate containing 0.1M sodium heptanesulfonate and 1mM disodium ethylenediaminetetraacetate (15 + 85). The compound of interest is detected at a glassy carbon electrode held at a potential of +0.9 V vs silver-silver chloride. The response is linear from 0 to 10 micrograms/mL terbutaline sulfate. The method is applicable to tablet composites, individual tablets, dissolution determinations, and injections. Results and supporting data are reported for the above analyses.
Food and Drug Administration, Boston, MA 02109.
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Childress
D002853:Chromatography, Liquid; D004563:Electrochemistry; D013607:Tablets; D013726:Terbutaline / Q000032:analysis*
D013607:Tablets; D013726:Terbutaline