[Specific features of the pharmacodynamics of drugs metabolized in the liver in experimental acute intestinal ileus].
The duration of action and the pharmacological activity of hexenal, phentanyl, meprobamate, corazole and sodium barbital were studied in male rats with acute intestinal ileus (AII) 12, 24, 48 and 72 hours after its reproduction and 24 hours after surgical treatment. A significant enhancement of the action of the studied drugs due to repression of their metabolism in the liver was observed in AII. The experimental findings should be taken into consideration during pharmacotherapy of patients with AII.
Nadzhimutdinov
K N
KN
Faingol'd
D Ia
DIa
Ashirmetov
A Kh
AKh
Krakovskii
M E
ME
Komarin
A S
AS
D000208:Acute Disease; D000818:Animals; D001462:Barbital / Q000494:pharmacology; D001711:Biotransformation; D005283:Fentanyl / Q000494:pharmacology; D007415:Intestinal Obstruction / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008620:Meprobamate / Q000494:pharmacology; D051381:Rats
D001462:Barbital; D008620:Meprobamate; D005283:Fentanyl
Osobennosti farmakodinamiki lekarstvennykh veschestv, metaboliziruiuschikhsia v pecheni, pri éksperimental'noĭ ostroĭ kishechnoĭ neprokhodimosti.