Loss of der(3) in renal carcinoma cells of a patient with constitutional t(3;12).
Cytogenetic studies were performed on peripheral lymphocytes, normal kidney cells, and tumor cells of a patient with renal cell carcinoma. Chromosome analysis of normal somatic cells revealed a constitutional t(3;12)(q13.2;q24.1) and a genomic instability involving the derivative chromosome 12. On the other hand, tumor cells were characterized by loss of der(3), supporting the hypothesis that loss of a specific 3p segment is associated with the development of renal cancer.
Cytogenetisches Labor, Institut für Pathologie, Hannover, Federal Republic of Germany.
G
G
Kovacs
E
E
Hoene
D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12; D002893:Chromosomes, Human, Pair 3; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
D005819:Genetic Markers