[Isolation and identification of an antileukemia substance from Coprinus radiatus].
Conditions for cultivation of basidiomycete Coprinus radiatus on agar media and its submersion fermentation were developed. An antibiotic was isolated from the fermentation broth filtrate by extraction with ethyl acetate followed by purification on a column with silica gel. The antibiotic had a pronounced in vivo effect on hemoblastosis La. Spectral analysis of the antibiotic (UV, IR, NMR and mass spectra) showed that it was identical to patulin (a toxin).
L N
LN
Anisova
Iu E
IuE
Bartoshevich
O A
OA
Efremenkova
O L
OL
Krasil'nikova
M K
MK
Kudinova
D000363:Agaricales / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis / Q000302:isolation & purification* / Q000627:therapeutic use; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003302:Coprinus / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005285:Fermentation; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D013329:Structure-Activity Relationship; D013997:Time Factors
D000970:Antineoplastic Agents
Vydelenie i identifikatsiia protivoleĭkoznogo veshchestva iz Coprinus radiatus.