Psammoma bodies in neuroendocrine carcinoma of the uterine cervix.
A case of neuroendocrine carcinoma of the uterine cervix with focal papillary clusters and psammoma bodies, features not previously seen in this tumor, is documented. Papanicolaou-stained cervicovaginal smears and pelvic washings are correlated with tissue sections of endocervical curettage, hysterectomy and cul-de-sac biopsy specimens. Although there was some variation in the cytologic features, the tumor cells were generally distinguished by nuclear molding, indistinct nucleoli, finely granular chromatin and scant cytoplasm. Argyrophil-positive intracytoplasmic granules were identified in tissue sections of the tumor. These granules were positive for ACTH and neuron-specific enolase using the immunoperoxidase technique. Ultrastructural studies were consistent with these findings. Neuroendocrine carcinoma of the cervix is therefore a cytologically distinctive tumor in which psammoma bodies may occur.
Department of Pathology, Temple University School of Medicine, Philadelphia, Pennsylvania.
V L
VL
Russin
P T
PT
Valente
P
P
Hanjani
D002277:Carcinoma / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004700:Endocrine System Diseases / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009423:Nervous System Neoplasms / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D009490:Neurosecretory Systems / Q000648:ultrastructure; D002583:Uterine Cervical Neoplasms / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure