Propranolol steady-state pharmacokinetics are unaltered by omeprazole.
In a randomised double-blind cross-over study, 8 normal subjects received propranolol 80 mg twice daily with omeprazole 20 mg or identical placebo each morning. Propranolol kinetics were measured on day 8 of both treatment periods. Areas under the propranolol concentration/time curves were not significantly increased by omeprazole treatment: off treatment mean 787.6, on treatment 802.5 ng-1.ml.h. Maximum and minimum steady-state propranolol concentrations were similarily unaffected. Omeprazole also failed to increase the clinical effect of propranolol, as assessed by exercise tests on Day 8 of treatment. We conclude that omeprazole in the dose likely to be used for peptic ulcer has no significant effect on the kinetics or action of propranolol.
Discipline of Clinical Pharmacology, Faculty of Medicine, Royal Newcastle Hospital, Australia.
D
D
Henry
P
P
Brent
I
I
Whyte
G
G
Mihaly
S
S
Devenish-Meares
D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D005080:Exercise Test; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000494:pharmacology*; D011433:Propranolol / Q000493:pharmacokinetics*
D011433:Propranolol; D009853:Omeprazole