Rodent lines selected for factors affecting alcohol consumption.
The selectively bred alcohol-preferring P and alcohol-nonpreferring NP lines of rats have been used to study the biology of alcohol-seeking behavior. The P rats satisfy all the perceived criteria for an animal model of alcoholism: free-fed animals voluntarily drink alcoholic solutions (10-30% v/v) to intoxication; they acquire metabolic and neuronal tolerance, and develop physical dependence; they work (bar-press) to obtain the alcohol and self-administer ethanol intragastrically. Drinking in the P rats ceases when blood alcohol concentrations (BACs) reach 50-70 mg%, but BACs subsequently rise to as high as 270 mg%. BACs, 15-70 mg%, elicit increased spontaneous motor activity in the P rats, but not in the NP rats. Acute tolerance to a single hypnotic dose of ethanol develops more rapidly and persists many days longer in the P than in the NP rats. These differences in the effects of ethanol may underlie the disparate alcohol drinking behaviors of the P and NP rats. The P rats also exhibit lowered serotonin levels in certain brain regions. Serotonin reuptake inhibitors curtail the alcohol drinking of the P rats, suggesting a role for serotonin in alcohol preference.
Indiana University School of Medicine, Indianapolis.
T K
TK
Li
L
L
Lumeng
W J
WJ
McBride
J M
JM
Murphy
D000428:Alcohol Drinking; D000437:Alcoholism / Q000235:genetics*; D000818:Animals; D001923:Brain Chemistry; D004195:Disease Models, Animal; D006801:Humans; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology; D012701:Serotonin / Q000032:analysis
D012701:Serotonin