Immunogenic potential of some mercury compounds in experimental contact allergy of the rat oral mucosa.
The contact allergenic potential of substances included in a "dental screening test" has been investigated in a previously established animal model for producing contact allergy. We were unable to produce contact hypersensitivity with any of the original formulas. HgCl2 was selected for further studies and, in order to improve its penetration, butanol was used as a solvent. Sensitization was, however, not obtained with any of the HgCl2/butanol formulas. Our results are discussed in relation to the requirements of reaching immunogenic threshold levels of mercury in the tissue.
Department of Oral Pathology, School of Dentistry, University of Lund, Malmö, Sweden.
B
B
Kinnby
R
R
Könsberg
A
A
Larsson
D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology; D005260:Female; D006967:Hypersensitivity / Q000209:etiology / Q000276:immunology*; D007114:Immunization; D008297:Male; D008628:Mercury / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D009061:Mouth Mucosa / Q000187:drug effects / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D013280:Stomatitis / Q000209:etiology / Q000276:immunology
D008628:Mercury