Enantiomeric cannabinoids: stereospecificity of psychotropic activity.
The 1,1-dimethylheptyl homolog of (-)-(3R,4R)-7-hydroxy-delta-6- tetrahydrocannabinol (compound II) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II).
Brettler Medical Research Center, Faculty of Medicine, Hebrew University, Jerusalem, Israel.
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Feigenbaum
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D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002186:Cannabinoids / Q000138:chemical synthesis / Q000494:pharmacology; D010856:Columbidae; D004305:Dose-Response Relationship, Drug; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D002186:Cannabinoids