Influence of pyridoxal 5'-phosphate on ethanol-induced changes in histamine catabolism in the guinea pig.
In guinea pigs, chronic intragastric administration of a 20% ethanol solution for 18 days (in increasing doses from 5 to 10 g/kg/day) leads, on the 18th day, to an enhancement of histamine level in the liver and the small intestine by up to 170% and 180% respectively. In these tissues the rate of histamine oxidative catabolism was depressed by about 20%. Histamine N-methyltransferase activity, as well as the level of acetylhistamine were not affected. Pyridoxal 5'-phosphate (2 mg/animal/day) tended to normalize both histamine levels and the rate of histamine oxidative catabolism.
Department of Biogenic Amines, Polish Academy of Sciences, Lodz.
D
D
Kierska
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K
Sasiak
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C
Maslinski
D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism*; D006637:Histamine N-Methyltransferase / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D011732:Pyridoxal Phosphate / Q000494:pharmacology*
D000431:Ethanol; D011732:Pyridoxal Phosphate; D006632:Histamine; D006637:Histamine N-Methyltransferase