Prenatal diagnosis of partial trisomy 22 derived from a maternal t(11; 22) (q23; q11).
A fetus with partial trisomy 22 was detected by amniocentesis in a pregnant woman with balanced translocation, 46, XX, t(11; 22) (q23; q11). The aborted fetus had multiple congenital anomalies consisting of microcephaly, cleft lip and palate. The extra acrocentric chromosome was identified as der (22), t(11; 22) (q23; q11). The aborted fetus is compared with other trisomic cases described in literatures, and perinatal diagnosis of this case was discussed.
Sou
S
S
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai.
Takabayashi
T
T
Sasaki
H
H
Sasamoto
K
K
Shintaku
Y
Y
Li
Z J
ZJ
Ozawa
N
N
Yajima
A
A
D000328:Adult; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014178:Translocation, Genetic; D014314:Trisomy