[Role of prolactin in changes of parasitism induced by lactation].
In order to establish the role played by prolactin in lactation during the evolution of Strongyloides ratti in the female rat, the authors tried to reproduce the effects of this physiological state by treatment with sulpiride (substituted benzamide), of which the prolactinogenic effect is intense in the female rat. Low doses partially reproduced the effects of lactation on parasitism by diminishing its intensity and delaying the onset of rejection, although without preventing it. The pharmacological action of sulpiride, which acts by blocking the dopamine receptors, explains why only low doses are active and why their action is limited to the onset of parasitism. This experiment lends weight to the hypothesis that prolactin plays a fundamental role in modifications of the evolution of Strongyloides ratti during lactation.
U. E. R. Pharmacie, Bordeaux.
J
J
Bailenger
P
P
Marcel
D000818:Animals; D003345:Corticosterone / Q000097:blood; D005243:Feces / Q000469:parasitology; D005260:Female; D007774:Lactation; D011247:Pregnancy; D011388:Prolactin / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013321:Strongyloides / Q000254:growth & development*; D013322:Strongyloidiasis / Q000097:blood / Q000469:parasitology; D013469:Sulpiride / Q000494:pharmacology*
D013469:Sulpiride; D011388:Prolactin; D003345:Corticosterone
Rôle de la prolactine dans les modifications du parasitisme induites par la lactation.