Methodology for detection of heterogeneity of cell locomotory phenotypes in three-dimensional gels.
A computer-driven, three-dimensional, optical, cell-tracking system was used to quantify the locomotory phenotypes of Mos-11 cells in a collagen gel. Factor analysis was used as a statistical means to make the complex variables generated by the system more tractable to analysis. Heterogeneity in locomotory behavior (two independent locomotory phenotypes) was detected among a sample of 54 cells.
Department of Oral Biology, Faculty of Dentistry, McGill University, Montreal, Canada.
E D
ED
Shields
P B
PB
Noble
D002460:Cell Line; D002465:Cell Movement; D003094:Collagen; D003201:Computers; D005782:Gels; D008722:Methods; D010641:Phenotype; D013223:Statistics as Topic
D005782:Gels; D003094:Collagen