Effects of treatment dose and intoxicated practice on the development of tolerance to ethanol-induced motor impairment.
The effect of treatment dosage and intoxicated practice on the development of tolerance to the motor-impairment effect of ethanol was examined. Within the treatment regimen employed (1.5-3.5 g/kg daily for 31 days), tolerance to the motor-impairment effect of ethanol developed whether or not the animals had opportunity to practice while intoxicated. The rate and extent of tolerance development were related to the ethanol treatment regimen. Intoxicated practice resulted in an enhancement of tolerance only at low treatment dosage (1.5-2.5 g/kg). These findings emphasize the treatment regimen as a critical variable in determining the rate and extent of tolerance development and the influence of intoxicated practice on such tolerance development.
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Addiction Research Foundation of Ontario, Toronto, Canada.
Kalant
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H
Khanna
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JM
D000435:Alcoholic Intoxication / Q000503:physiopathology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D009068:Movement / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol