Infection and transformation of Fv-2rr erythroprogenitor cells with Friend virus.
Friend virus was used to infect and transform Fv-2rr erythroprogenitor cells in vivo. The RB (Fv-2rr) cell line was characteristic of Friend virus-induced cell lines in Fv-2ss mice, i.e., it produced infectious Friend virus and synthesized hemoglogin. The RB (Fv-2rr) cell line expressed the envelope protein of the spleen focus-forming virus (gp52) and a novel, related envelope protein (gp48). The results demonstrate that Fv-2rr erythroprogenitor cells can be infected and transformed in vivo.
Terre Haute Center for Medical Education, Indiana Unviersity School of Medicine, Terre Haute 47809.
R W
RW
Geib
M
M
Dizik
R
R
Anand
F
F
Lilly
D000818:Animals; D002472:Cell Transformation, Viral; D005622:Friend murine leukemia virus / Q000254:growth & development*; D006023:Glycoproteins / Q000096:biosynthesis; D006412:Hematopoietic Stem Cells / Q000382:microbiology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000382:microbiology; D008970:Molecular Weight; D014764:Viral Proteins / Q000096:biosynthesis
D006023:Glycoproteins; D014764:Viral Proteins