Acetylation, deacetylation and hydroxylation of sulphamethoxazole and N4-acetylsulphamethoxazole in the turtle Pseudemys scripta elegans.
The turtle Pseudemys scripta elegans is able to hydroxylate and acetylate Sulphamethoxazole in a way that is comparable to man, i.e. the rate and yield of hydroxylation equals that of the acetylation. The hydroxy metabolites 5-hydroxy- and N4-acetyl-5-hydroxysulphamethoxazole are not glucuronidated. N4-acetylsulphamethoxazole is neither deacetylated nor hydroxylated.
Department of Clinical Pharmacy, St. Radboud Hospital, University of Nijmegen, The Netherlands.
T B
TB
Vree
J B
JB
Vree
Y A
YA
Hekster
J F
JF
Nouws
D000107:Acetylation; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006900:Hydroxylation; D013420:Sulfamethoxazole / Q000031:analogs & derivatives* / Q000378:metabolism*; D014426:Turtles / Q000378:metabolism*
C021282:N(4)-acetylsulfamethoxazole; D013420:Sulfamethoxazole