Miconazole sorption to intravenous infusion sets.
The sorption of the antifungal drug miconazole onto the plastics of infusion bags and intravenous administration sets has been investigated. HPLC methodology was applied for the determination of miconazole concentrations. The results obtained indicate that the sorption of miconazole is low and is unlikely to result in significant loss of clinical efficacy.
Department of Pharmacy, Queen's University of Belfast, Medical Biology Centre, Northern Ireland.
A G
AG
McGookin
J S
JS
Millership
E M
EM
Scott
D000327:Adsorption; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007202:Indicators and Reagents; D007262:Infusions, Intravenous; D007654:Ketoconazole / Q000032:analysis; D008825:Miconazole / Q000008:administration & dosage / Q000032:analysis*
D007202:Indicators and Reagents; D008825:Miconazole; D007654:Ketoconazole