Experimental models for the study of chronoimmunomodulation (rhythms of the springtail Folsomia candida, Collembola: Isotomidae).
A third-generation cephalosporine, cefodizime, was tested in two experiments on the springtail, Folsomia candida, used as a model of infradian rhythmicity. Any effect on ecdysis (molt), oviposition and oviproduction was sought for 6, 20 or 60 ng of cefodizime administered with brewer's yeast every other day, as compared to controls given only the yeast. Results indicate that a 20-ng dose of cefodizime on alternate days may shorten an infradian period (of molt) in the springtail.
Universidad de São Paulo, Brazil.
M D
MD
Marques
G
G
Cornélissen
L K
LK
Cutkomp
F
F
Halberg
N
N
Marques
D000276:Adjuvants, Immunologic; D000818:Animals; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D007313:Insecta / Q000502:physiology*; D010058:Oviposition; D010507:Periodicity / Q000187:drug effects*
D000276:Adjuvants, Immunologic; D002439:Cefotaxime; C033356:cefodizime