Interaction of drugs and the adenosine-uptake system of endothelial cells may influence the regulation of the heart by adenosine.
The uptake of adenosine by endothelial cells may be an important step in the metabolic regulation of the heart blood flow by adenosine. Cultivated endothelial cells served as a model for investigations of the inhibitory activity of vasoactive drugs on adenosine uptake by vascular endothelium. Dipyridamole, papaverine, prazosine, and nifedipine inhibited the adenosine uptake. This process depends also on energy metabolism of the endothelial cells.
Ernst-Moritz-Arndt-University, Department of Pharmacy, Greifswald, GDR.
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Melzig
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Teuscher
D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology*; D002460:Cell Line; D003326:Coronary Circulation / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects
D002317:Cardiovascular Agents; D000241:Adenosine