Pancreatic steatorrhea: action of a total lyophilized pancreas preparation: an "in vitro" and "in vivo" study.
A total lyophilized pig pancreas (TLP) preparation was assayed "in vitro" and "in vivo". Lipase activity of the four lots studied was 6.180 +/- 1.122 IU by gram of the commercial product. There was no free trypsin detectable in the preparation. Fifteen pancreatic exocrine insufficiency patients were studied in a period of four weeks. Adult patients received from 35.500 to 35.776 IU of lipase contained in TLP preparation by meal. All patients had their steatorrhea reduced, or normalized, stool weight reduced and body weight increased. There is not an obligatory relation between stool fat loss and stool weight. Steatorrhea decreased at least during the 14 first days of treatment before reaching a stable level. This long delay before reaching a maximum effect deserves to be known: to test the efficiency of a pancreatic extract, the treatment must be given at least two weeks before estimating its results on fecal fat excretion.
School of Medicine, Federal University of Minas Gerais, Brasil.
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Dani
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Ribeiro
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FJ
Penna
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Nogueira
D000293:Adolescent; D000328:Adult; D001835:Body Weight; D002446:Celiac Disease / Q000178:diet therapy / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005223:Fats / Q000032:analysis; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D008049:Lipase / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D010184:Pancreatic Extracts / Q000627:therapeutic use*; D010195:Pancreatitis / Q000178:diet therapy* / Q000188:drug therapy / Q000201:enzymology
D005223:Fats; D010184:Pancreatic Extracts; D008049:Lipase