[Normalization of the adaptive avoidance reaction in rats using substances with nootropic activity].
The system of double coaxial cylinders filled with water was used as a device for studying simple extrapolation behaviour of rats. The amount of rats which were able to dive under the lower edge of the inner cylinder, without reaching the bottom of the outer cylinder and the latency of this avoidance reaction were considered as a measure of extrapolation ability. This reaction was altered by the pretreatment of animals with cycloheximide, a protein synthesis inhibitor. Piracetam as a standard nootropic, sodium and lithium hydroxybutyrate as substances with a potential nootropic effect were shown to be able to antagonize the damaging effect of cycloheximide on the avoidance performance. Benzodiazepine tranquilizer, phenazepam, in contrast to nootropics, evokes additional worsening of extrapolation reaction. Normalization of avoidance disturbed by cycloheximide, can be used as an adequate and informative approach for screening of nootropics.
Savchenko
N M
NM
Ostrovskaia
R U
RU
Burov
Iu V
IuV
D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D014151:Anti-Anxiety Agents; D001362:Avoidance Learning / Q000187:drug effects*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D004347:Drug Interactions; D006885:Hydroxybutyrates / Q000494:pharmacology; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012978:Sodium Oxybate / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D006885:Hydroxybutyrates; D009942:Organometallic Compounds; D011619:Psychotropic Drugs; D001569:Benzodiazepines; C017928:phenazepam; C022826:lithium hydroxybutyrate; D012978:Sodium Oxybate; D003513:Cycloheximide; D010889:Piracetam
Normalizatsiia adaptivnoĭ reaktsii izbavleniia u krys veshchestvami s nootropnoĭ aktivnost'iu.