Titrimetric determination of nonesterified fatty acids in intravenous fat emulsions.
A titrimetric method, suitable for use at a limit of 5 mEq/L, has been developed for the determination of total nonesterified fatty acids in intravenous fat emulsion preparations. The method differentiates titrant consumed by the nonesterified fatty acids from that consumed by egg yolk phospholipids, usually present as an emulsifying agent. The total nonesterified fatty acids in 8 products from 4 manufacturers were in the range from 0.4 to 3.8 mEq/L. The mean standard deviation of the method is 0.09 mEq/L.
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Health and Welfare Canada, Health Protection Branch, Tunney's Pasture, Ottawa, Ontario.
Lawrence
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Lovering
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D005217:Fat Emulsions, Intravenous / Q000032:analysis*; D005230:Fatty Acids, Nonesterified / Q000032:analysis*; D010743:Phospholipids / Q000032:analysis; D012996:Solutions
D005217:Fat Emulsions, Intravenous; D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D012996:Solutions