Clinical applications of Ga-67 DFO-DAS-fibrinogen.
As a result of our preliminary study which confirmed the safety and promising clinical usefulness of 67Ga-DFO-DAS-fibrinogen, scintigrams were taken on seven patients with suspected thrombosis. No evidence of radioactivity accumulation was found in the sites of suspected thrombi. However, in one patient accumulation of 67Ga-fibrinogen was observed in thrombi localized in the obstructed internal shunt for hemodialysis. A photon-deficient area corresponding to a gigantic thrombus in the left atrium was seen in an early 67Ga-fibrinogen image in a patient with mitral stenosis. Accumulation of radioactivity in the atrial thrombus was not observed in a later image. The necessity of performing 67Ga-fibrinogen scintigraphy in the acute phase of thrombus formation is discussed. The promising usefulness of 67Ga-fibrinogen for the early detection of thrombus formation in internal shunts for hemodialysis is also emphasized.
Department of Nuclear Medicine, Gunma University School of Medicine, Japan.
Y
Y
Sasaki
T
T
Inoue
M
M
Noguchi
Y
Y
Kawamura
K
K
Uchida
T
T
Watanuki
D000328:Adult; D000368:Aged; D003676:Deferoxamine; D005260:Female; D005340:Fibrinogen; D005710:Gallium Radioisotopes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013213:Starch / Q000031:analogs & derivatives; D013927:Thrombosis / Q000000981:diagnostic imaging*
D005710:Gallium Radioisotopes; D005340:Fibrinogen; D013213:Starch; C012880:dialdehyde starch; D003676:Deferoxamine