Mitotic figures of glial fibrillary acidic protein-positive cells in the periphery of human brain abscess.
It has been unclear until now as to whether human astrocytes proliferate through mitosis or through amitosis, and little attention has been paid to the biological meaning of glial cell division. We examined an autopsy case of a 53-year-old man who died of brain abscesses and have found GFAP-positive mitotic cells in the zone between the abscess cavity and the reactive gliosis. The results suggest that human normal astrocytes which act in response to the brain abscess proliferate the process of mitosis, and become reactive to repair the lesions.
Department of Pathology, Niigata University, Japan.
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Motegi
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Kawai
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Ikuta
D001253:Astrocytes / Q000473:pathology*; D001922:Brain Abscess / Q000378:metabolism / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008938:Mitosis
D005904:Glial Fibrillary Acidic Protein