Effects of cisapride on constipation due to a neurological lesion.
Two patients with intractable constipation and an atonic bladder due to a partial spinal cord lesion and sacral nerve lesion are described. Treatment with cisapride (4 x 10 mg daily) was undertaken. After a few days the stool passed spontaneously. The effect was dose-dependent and has been maintained for at least 40 months. Normal bladder function was not achieved.
Department of Internal Medicine, St Jozef Hospital, Heemskerk, The Netherlands.
G H
GH
de Groot
G F
GF
de Pagter
D000328:Adult; D002908:Chronic Disease; D020117:Cisapride; D003248:Constipation / Q000188:drug therapy* / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D005772:Gastrointestinal Transit / Q000187:drug effects; D006801:Humans; D008160:Lumbosacral Plexus / Q000293:injuries; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000150:complications*; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy
D010880:Piperidines; D020117:Cisapride