Inter-relationship among individual vitamin K-dependent clotting factors at different levels of anticoagulation.
1. The effect of subtherapeutic doses of warfarin on the activities of the four vitamin K-dependent clotting factors was studied at steady state in five patients each of whom had completed a therapeutic course of anticoagulation. 2. The four clotting factor activities were shown to be depressed to a similar extent for a given dose of warfarin. 3. The prothrombin complex activity was significantly lower than that of any of the clotting factors.
Pharmacokinetics Department, University of Manchester.
E
E
Chan
L
L
Aarons
M
M
Serlin
A
A
Breckenridge
M
M
Rowland
D000368:Aged; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time; D014812:Vitamin K / Q000502:physiology*; D014859:Warfarin / Q000494:pharmacology
D001779:Blood Coagulation Factors; D014812:Vitamin K; D014859:Warfarin