pH and P.E.G.-400 effects on flucloxacillin absorption.
1. Intestinal clearances of flucloxacillin significantly decrease with the increase of pH, concomitantly with a decrease of the percent absorbed at 60 min. 2. The apparent rate constants for unionized (Ku) and ionized species are 0.173 min-1 and 0.017 min-1 respectively. 3. The addition of P.E.G.-400 at different concentrations significantly enhanced intestinal clearances of flucloxacillin parallel to an increase of net water flux from the lumen of the small intestine.
Laboratory of Pharmacology, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago.
L J
LJ
Nuñez-Vergara
I R
IR
Lemus
J A
JA
Squella
D000818:Animals; D003023:Cloxacillin / Q000031:analogs & derivatives*; D005436:Floxacillin / Q000493:pharmacokinetics*; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000378:metabolism; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011092:Polyethylene Glycols; D005436:Floxacillin; D003023:Cloxacillin