The influence of dopamine agonists and antagonists on gastric lesions in mice.
The dopamine agonist bromocriptine and L-dopa significantly inhibited whereas dopamine antagonist haloperidol aggravated the gastric lesions induced by pylorus ligation in mice as found earlier for rats. Furthermore, the successful use of a dopamine antagonist alone for the induction of gastric lesions also in mice was demonstrated, since the gastric lesions were induced by a single dose of haloperidol without any additional noxious treatment. Bromocriptine successfully inhibited both the gastric lesion-potentiating as well as the gastric lesion-inducing effect of haloperidol.
Department of Pharmacology, Medical Faculty, University of Zagreb, Yugoslavia.
P
P
Sikirić
I
I
Rotkvić
S
S
Mise
S
S
Krizanac
E
E
Suchanek
M
M
Petek
V
V
Gjuris
J
J
Geber
M
M
Tućan-Foretić
I
I
Udovicić
D000818:Animals; D001971:Bromocriptine / Q000633:toxicity*; D018492:Dopamine Antagonists; D005260:Female; D006220:Haloperidol / Q000633:toxicity*; D007980:Levodopa / Q000633:toxicity*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011708:Pylorus / Q000187:drug effects*; D013276:Stomach Ulcer / Q000139:chemically induced*
D018492:Dopamine Antagonists; D001971:Bromocriptine; D007980:Levodopa; D006220:Haloperidol