Sex-related differences in food and water intake and body weight changes with prolonged administration of adrenaline in the rat.
Male and female rats were treated with different high doses of adrenaline for five days. Their food and water intakes and body weights were recorded. A considerable sex-difference was found on the 5th day in body weights and plasma glucose concentrations. Males had higher plasma glucose and lost more weight than females. Females ate and drank more than males throughout the experiment. The adrenaline-sensitivity of females decreased by the third day but it did not change in males. These data suggest that females are able to activate mechanisms that compensate the effects of high adrenaline levels while males are not, or their compensatory mechanisms are less efficient.
Neurophysiology Research Group of the Hungarian Academy of Sciences, Institute of Physiology, University Medical School, Pécs.
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Z
Hahn
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Karádi
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P
Sándor
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Lénárd
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012737:Sex Factors
D001786:Blood Glucose; D004837:Epinephrine