Atypical malformations in an infant exposed to warfarin during the first trimester of pregnancy.
We report a dysmorphic female infant whose mother took warfarin in therapeutic doses during the first 6 weeks of pregnancy. At birth the infant was small for dates and had a triangular facial appearance, micrognathia, microglossia, short fingers and toes, and hypoplastic nails. A skeletal survey revealed hypoplastic distal phalanges in the fingers and toes; there was no epiphyseal stippling. The pattern of malformations present in this infant may either represent the earliest teratogenic effects of warfarin or the fortuitous association of exposure to warfarin and unexplained dysmorphic features.
Ruthnum
P
P
Southern General Hospital, Glasgow, Scotland.
Tolmie
J L
JL
D000014:Abnormalities, Drug-Induced; D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D013723:Teratogens; D014859:Warfarin / Q000009:adverse effects*
D013723:Teratogens; D014859:Warfarin