The stability of 5,6-dihydrofluorouracil in plasma and the consequences for its analysis.
This study shows that 5,6-dihydrofluorouracil kept in plasma at room temperature deteriorates in time. Preservation is gained by low temperature and low pH of plasma samples. Therefore, plasma samples should be buffered and frozen immediately after being obtained, and thawing should proceed to 5 degrees C only.
van den Bosch
N
N
Department of Pharmacology, University of Leiden, The Netherlands.
Driessen
O
O
van der Velde
E A
EA
Erkelens
C
C
D004355:Drug Stability; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000097:blood; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D013048:Specimen Handling; D013696:Temperature
C019389:5-fluorodihydrouracil; D005472:Fluorouracil