Activity of newer beta-lactam agents against clinical isolates of Bacteroides fragilis and other Bacteroides species.
The in vitro activities of beta-lactam antibiotics against Bacteroides fragilis and B. fragilis group isolates are presented. Clinical isolates from 1986 were compared with strains from 1979 to 1982. Imipenem, ticarcillin-clavulanic acid, and ceftizoxime were the most active agents. Cefotetan was equivalent to cefoxitin against B. fragilis but less active against B. fragilis group isolates. Enhancement of cefotaxime by its desacetyl metabolite was minimal.
Infectious Disease Research Laboratory, Loyola University Medical Center, Maywood, Illinois 60153.
J P
JP
O'Keefe
F R
FR
Venezio
C A
CA
DiVincenzo
K L
KL
Shatzer
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001439:Bacteroides / Q000187:drug effects*; D001442:Bacteroides Infections / Q000382:microbiology; D001441:Bacteroides fragilis / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams