Enhancing effect of phenobarbital sodium on Tyzzer's disease in mice.
Tyzzer's disease in mice was aggravated by phenobarbital sodium (PB) given consecutively after bacterial inoculation. In PB-treated mice, mortality rate and severity of liver lesions were higher with more prominent bacterial propagation in hepatocytes as compared with non-treated ones, suggesting that PB had an enhancing effect on metabolic activities of host hepatocytes resulting in increased intracellular growth of bacteria.
Department of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Japan.
M
M
Xian
S
S
Inoue
N
N
Matsunuma
N
N
Goto
K
K
Fujiwara
D000818:Animals; D001407:Bacillus; D001424:Bacterial Infections / Q000473:pathology*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology*; D051379:Mice; D008813:Mice, Inbred ICR; D009336:Necrosis; D010634:Phenobarbital / Q000494:pharmacology*
D010634:Phenobarbital