Translocation (3;6)(q21;p21) in acute myeloid leukemia with abnormal thrombopoiesis and basophilia.
A case of acute myeloid leukemia (AML) with increased numbers of basophils and abnormal megakaryocytes was shown to have a t(3;6)(q21;p21) in the bone marrow cells. The morphology is described in detail and the case is discussed with reference to t(6;9)(p23;q34) and inv/ins(3)(q21q26) in AML. It is possible that increased numbers of basophils in AML may be associated with a translocation involving 6p21-6p23.
Department of Haematological Medicine, University of Cambridge Clinical School, UK.
C F
CF
Hoyle
P
P
Sherrington
F G
FG
Hayhoe
D000328:Adult; D001491:Basophils / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology*; D002893:Chromosomes, Human, Pair 3; D002896:Chromosomes, Human, Pair 6; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000235:genetics* / Q000473:pathology; D008297:Male; D010976:Platelet Count; D014178:Translocation, Genetic
D005819:Genetic Markers