Correlation of morphological variables in germ-cell hypoplasia.
The correlations between the progression of germ-cell hypoplasia, measured with the Johnsen's score, reduction in tubular diameter, and thickening of the lamina propria of the seminiferous tubules were studied in a series of 42 biopsy specimens of the testis from 26 infertile men. There was a significant negative correlation between the mean tubular diameter and the mean thickness of the lamina propria (p less than 0.01), as well as a significant positive correlation between the Johnsen's score and the mean tubular diameter (p less than 0.01). The Johnsen's score did not correlate with the mean thickness of the lamina propria. Reduction of the tubular diameter and thickening of the lamina propria could be found across the spectrum of scores, but they prevailed in severe germ-cell hypoplasia.
Istituto di Anatomia Patologica, I Cattedra, Università di Genova, Italy.
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D000328:Adult; D005854:Germ Cells / Q000473:pathology*; D006801:Humans; D007248:Infertility, Male / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012671:Seminiferous Tubules / Q000473:pathology*; D013737:Testis / Q000473:pathology*