[Action of Soviet chemical preparations, reaferon and inducers on the reproduction of HTLV-III retrovirus].
The effect of some Soviet chemical drugs (ribamydil, sodium phosphonoformate, acycloguanosine) as well as reaferon (genetic engineering alpha-interferon) and interferon inducers (lafarine, ridastine, rifastine, ENKAD) on HIV retrovirus reproduction was studied in cultures of continuous lymphoid cells H9 and a line of H9/IIIB cells persistently infected with HIV virus. The presence of viral antigen in the cells was determined by quantitative indirect immunofluorescence assays using a working dilution of 1:20 of a serum from an AIDS patient as the immune serum. The above studies showed that 3 drugs: ribamydil (50 micrograms/ml), phosphonoformate (120 micrograms/ml) and recombinant interferon (1000 IU/ml) were capable of statistically significant inhibition of retrovirus replication in continuous cultures of T-lymphocytes.
Barinskiĭ
I F
IF
Gribencha
S V
SV
Nesterchuk
S L
SL
Zhdanov
V M
VM
D000998:Antiviral Agents / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D007369:Interferon Inducers / Q000494:pharmacology*; D007370:Interferon Type I / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology; D013997:Time Factors; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D007369:Interferon Inducers; D007370:Interferon Type I; D011994:Recombinant Proteins
Izuchenie deĭstviia otechestvennykh khimiopreparatov, reaferona i induktorov na reproduktsiiu retrovirusa HTLV-III.