Effects of naloxazone on morphine-ethanol interaction in the conditioned taste aversion paradigm.
The effects of naloxazone on the interaction between alcohol and morphine were examined in the conditioned taste aversion paradigm (CTA). Naloxazone injected 4.5 h before the pre-exposure drug significantly attenuated the pre-exposure effect of morphine on ethanol CTA as well as the effect of ethanol on morphine CTA. The results are discussed in terms of possible mechanisms of opiate-alcohol interaction.
Dept. of Psychology, Concordia University, Montreal, Que., Canada.
J M
JM
Ng Cheong Ton
Z
Z
Amit
D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects; D004347:Drug Interactions; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000378:metabolism / Q000494:pharmacology*; D009270:Naloxone / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000187:drug effects*
D009270:Naloxone; D000431:Ethanol; C024224:naloxazone; D009020:Morphine