Suxamethonium induced myalgia and the effect of pre-operative administration of oral aspirin. A comparison with a standard treatment and an untreated group.
Eighty-four fit, unpremedicated patients who presented for routine surgery and received a standard anaesthetic technique were allocated randomly to three equal groups. Group 1 received tubocurarine 0.05 mg/kg before induction of anaesthesia. Group 2 received soluble aspirin 600 mg orally one hour before surgery, while Group 3 received no pretreatment. Aspirin prophylaxis produced a significant reduction in the incidence of subsequent suxamethonium-induced myalgia and the improvement was similar to that achieved with tubocurarine pretreatment. Pre-operative oral administration of aspirin effectively reduces muscle pains and avoids many of the complications associated with pretreatment with non-depolarising agents.
McLoughlin
C
C
Mater Infirmorum Hospital, Belfast, Northern Ireland.
Nesbitt
G A
GA
Howe
J P
JP
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles; D010146:Pain / Q000517:prevention & control*; D011292:Premedication; D013390:Succinylcholine / Q000009:adverse effects*; D014403:Tubocurarine / Q000627:therapeutic use
D013390:Succinylcholine; D001241:Aspirin; D014403:Tubocurarine