[Wilson's disease: demonstration of lesions of the cortex and white matter by MRI].
Lesions of cortex and white matter are present in Wilson's disease in approximately 10 p. cent of cases. Before Magnetic Resonance Imaging (MRI) only post-mortem examination evidenced them. We report the case of a 15 year-old girl in whom Wilson's disease was diagnosed after partial motor epileptic seizures. She later presented with progressive extrapyramidal and pyramidal signs, severe cognitive weakening and disorder of behaviour. MRI clearly showed cortical and subcortical lesions by an enhanced signal (T2 values). It showed as well the classical picture of lesion in the lenticular nuclei. With T1 values it showed an extensive cortical atrophy and a widening of the ventricules.
Service de Neurologie, Hôpital Pellegrin, Bordeaux.
D
D
Le Fort
B
B
Deleplanque
P
P
Louiset
B
B
Pautrizel
P
P
Loiseau
D000293:Adolescent; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D004569:Electroencephalography; D005260:Female; D006527:Hepatolenticular Degeneration / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging
Maladie de Wilson: démonstration de lésions corticales et de la substance blanche par IRM.