The pharmacokinetics of D-penicillamine in neonates.
The pharmacokinetics of D-penicillamine in premature babies was studied. The metabolism of the drug was characterized by a long half-life (115 min) with a low plasma clearance (2.84 ml/min/kg body weight) in contrast to adults. The mean volume of distribution (649/ml/kg body weight) was similar to that of adults.
Oroszlán
G
G
Department of Paediatrics, Debrecen University Medical School, Hungary.
Szabó
T
T
Lakatos
L
L
Márton
G
G
D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D008657:Metabolic Clearance Rate; D010406:Penicillins / Q000097:blood / Q000493:pharmacokinetics*
D010406:Penicillins