Synthesis and search for anticonvulsive and hypoglycemic properties of novel 5-benzylidene derivatives of 3-o-chloro- and 3-o-methylbenzoyl-2-thiohydantoin.
14 new benzylidene derivatives of 3-o-chloro- and 3-o-methylbenzoyl-2 thio hydantoin were synthesized. Their chemical structure was confirmed by IR, NMR and mass spectroscopy. Compounds 1-14 were tested for their anticonvulsant and hypoglycemic activity. Their toxicity was low and they showed only weak activity in tests for anticonvulsive and hypoglycemic properties.
Department of Pharmacology, Medical Academy, Lublin, Poland.
Z
Z
Kleinrok
W
W
Sermak
M
M
Kozicka
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D001565:Benzoates / Q000138:chemical synthesis / Q000494:pharmacology; D005260:Female; D006827:Hydantoins / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013055:Spectrophotometry, Infrared; D013867:Thiohydantoins / Q000138:chemical synthesis / Q000494:pharmacology*
D000927:Anticonvulsants; D001565:Benzoates; D006827:Hydantoins; D007004:Hypoglycemic Agents; D013867:Thiohydantoins