Suppression of the lymphoproliferative response by positively charged liposomes.
The efficiency of positively-charged liposomes as immunomodulators was investigated in vitro using a lymphoproliferative response assay on cultured human lymphocytes challenged either with different polyclonal activators or with actin, a cytoskeletal protein of poor immunogenicity. Our results indicate that these liposomes suppress the [3H]thymidine incorporation in lymphocyte cultures and inhibit the mitogen-induced proliferation without, however, exhibiting significant cytotoxicity.
Département de Chimie-Biologie, Université du Québec à Trois-Rivières, Canada.
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Thérien
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Gruda
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Lieu
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Dion
D000199:Actins / Q000494:pharmacology; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D008081:Liposomes / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology
D000199:Actins; D037102:Lectins; D008081:Liposomes