Histological examination of combined effects of chemotherapeutical agents and differently fractionated irradiations in transplanted solid Ehrlich carcinoma of mice. III. Observations after vincristine treatment.
Vincristine treatment alone does not evoke estimable histological damage in solid Ehrlich carcinoma. However, when combined with fractionated local X-irradiation it causes more severe damage than the irradiation alone, consequently vincristine has a synergistic effect in radiation therapy. Comparing the effects of irradiation of the same total dose fractionated differently and combined with vincristine, one cannot find any characteristic and consequent histological differences.
Frédéric Joliot-Curie National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary.
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Unger
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D003131:Combined Modality Therapy; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects / Q000528:radiation effects; D009368:Neoplasm Transplantation; D011879:Radiotherapy Dosage; D013997:Time Factors; D014750:Vincristine / Q000627:therapeutic use*
D014750:Vincristine