Involutional and developmental implications of age-related neuronal changes: in search of an engram for wisdom.
The changes in neuronal size and number that occur with aging can be viewed from a developmental rather than an involutional perspective. According to this speculative vantage point, age-related neuronal attrition need not lead to intellectual decline and may, instead, represent a progressive fine-tuning of cerebral networks.
Mesulam
M M
MM
Harvard Medical School Department of Neurology, Boston, MA 02215.
D000375:Aging / Q000473:pathology* / Q000502:physiology; D001921:Brain / Q000254:growth & development / Q000473:pathology* / Q000502:physiology; D002452:Cell Count; D006801:Humans; D007858:Learning / Q000502:physiology*; D009474:Neurons / Q000473:pathology*