Vancomycin entry into lung lymph in sheep.
The distribution of antibiotics into target tissues is a crucial factor in therapeutic efficacy. To estimate the availability of systemically administered vancomycin to the interstitial fluid in the lung, we have used a sheep model with a chronic pulmonary lymph fistula to collect simultaneously series of plasma and pulmonary lymph specimens during a 6-h period after an intravenous dose of vancomycin (7 mg/kg). After a minor delay in transit from blood to lymph, vancomycin was completely distributed to pulmonary lymph with a ratio of free drug in lymph to free drug in plasma of 0.9. This suggests that vancomycin is an excellent choice for treating pulmonary infections by susceptible organisms.
May
D G
DG
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Stratton
C W
CW
Denney
W D
WD
Watts
F L
FL
Bernard
G R
GR
Branch
R A
RA
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D008168:Lung / Q000378:metabolism*; D008196:Lymph / Q000378:metabolism*; D010539:Permeability; D011485:Protein Binding; D012756:Sheep; D014640:Vancomycin / Q000493:pharmacokinetics*
D001798:Blood Proteins; D014640:Vancomycin