Dithiocarbamate inhibition of cadmium-induced changes in spermatozoan acetyltransferases.
The administration of sodium N-methyl-N-dithiocarboxy-D-glucamine (NaG) subsequent to the administration of CdCl2.2.5H2O to male rats, inhibits the cadmium-induced decreases in spermatozoan acetyltransferase (AT) levels and provides marked protection against the cadmium-induced morphologic testicular changes in the cauda and corpus and partial protection against the changes in the caput.
Dwivedi
C
C
Department of Medical Genetics, Meharry Medical College, Nashville, Tennessee 37208.
Kumar
S S
SS
Walker
E M
EM
Jones
S G
SG
Jones
M M
MM
D000123:Acetyltransferases / Q000378:metabolism*; D000818:Animals; D002104:Cadmium / Q000037:antagonists & inhibitors / Q000633:toxicity*; D002105:Cadmium Poisoning / Q000473:pathology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013094:Spermatozoa / Q000187:drug effects / Q000201:enzymology*; D013737:Testis / Q000473:pathology; D013859:Thiocarbamates / Q000494:pharmacology*
D013859:Thiocarbamates; D002104:Cadmium; D000123:Acetyltransferases