[Radioprotective action of natural carotene-containing preparations: research on karotinil in white rats].
Evidence was obtained that beta-carotene injected to rats subcutaneously or per os two times, 4 h and 19 h, before irradiation reduced their death rate from acute affection. The effect was almost invariable with the drug administered either before or after irradiation. The radioprotective efficacy of beta-carotene was attributed to its ability to scavenge active oxygen forms.
Vilenchik
M M
MM
Gikoshvili
T I
TI
Kuzin
A M
AM
Moskalev
Iu I
IuI
Stepanov
S V
SV
D000208:Acute Disease; D000818:Animals; D001773:Blood Cells / Q000187:drug effects / Q000528:radiation effects; D002338:Carotenoids / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005720:Gamma Rays; D008297:Male; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000401:mortality; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D019207:beta Carotene
D011837:Radiation-Protective Agents; D019207:beta Carotene; D002338:Carotenoids
Radiozashchitnoe deĭstvie prirodnykh karotinsoderzhashchikh preparatov: issledovanie karotinila na belykh krysakh.