Role of the lymphatic circulatory system in shock.
That the lymphatic vessel participates in the regulation of interstitial dynamics through its ability to contract and propel fluid and protein from the extravascular tissues back to the bloodstream has not been fully appreciated. The "lymph pump" appears to be regulated by local physiologic forces as well as neurogenic and humoral factors. We have assessed the effects of hemorrhage and endotoxin on the ability of the lymph vessel to propel fluid in sheep using a model system that permits the quantitation of lymphatic pumping in vivo without the complication of variable lymph inputs. A major blood loss was found to enhance lymphatic contractile activity and fluid pumping. Considering the large reservoir of fluid and protein in the interstitium and lymph, we speculate that stimulation of the "lymph pump" after hemorrhage might help to re-expand the vascular space. On the other hand, the intravenous administration of endotoxin inhibited lymphatic pumping, suggesting that impaired lymph propulsion in sepsis may contribute to edema by reducing the ability of the lymphatic vessel to remove extravasated protein from the tissues.
Department of Pathology, University of Toronto, Ontario, Canada.
M G
MG
Johnston
R M
RM
Elias
A
A
Hayashi
W
W
Nelson
D000818:Animals; D004731:Endotoxins / Q000633:toxicity; D008196:Lymph / Q000502:physiology; D008208:Lymphatic System / Q000502:physiology*; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000503:physiopathology; D011312:Pressure; D011453:Prostaglandins / Q000502:physiology; D012756:Sheep; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D012772:Shock, Septic / Q000503:physiopathology*
D004731:Endotoxins; D011453:Prostaglandins