Calcium antagonists inhibit the motility of washed human spermatozoa.
The effect of three clinically well-known calcium antagonists (nifedipine, verapamil and diltiazem) on the motility of washed human spermatozoa was investigated by Laser Doppler spectroscopy. In contrary to other investigations, a motility and velocity inhibiting influence of all three substances, especially of nifedipine, was observed.
Department of Dermatology, Ludwig-Maximilians-University of Munich, West Germany.
R
R
Placzek
H
H
Ohling
U
U
Waller
F
F
Krassnigg
W B
WB
Schill
D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004110:Diltiazem / Q000494:pharmacology; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D013081:Sperm Motility / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine