Relationship between lipoprotein lipase activity and plasma sex steroid level in obese women.
In obese women (n = 16) at their weight, fasting adipose tissue lipoprotein lipase (LPL) activity, obtained by elution with serum and heparin at 4 degrees and 37 degrees C, was inversely correlated to plasma estradiol levels (r = -0.724; P = 0.002) and (r = -0.641; P = 0.010), respectively. Furthermore, fasting postheparin plasma LPL activity during a heparin infusion, showed an even stronger inverse correlation to plasma estradiol when measured at 60 min (r = -0.815; P less than 0.001). None of the above parameters was correlated to the body mass index. Postprandial LPL activity in postheparin plasma, measured 10 min after a heparin injection, showed a strong positive correlation with plasma free testosterone (r = 0.780; P = 0.001). Neither of these parameters was correlated with the body mass index. The origin of this LPL activity is presently unknown but could conceivably represent a pool of LPL from skeletal muscle. Since it has been shown convincingly that estrogen decreases adipose tissue LPL activity in the rat, the present studies strongly suggest that estradiol is a major negative regulator of fasting adipose tissue LPL activity in women.
Iverius
P H
PH
Department of Medicine, University of Washington, Seattle 98195.
Brunzell
J D
JD
D000273:Adipose Tissue / Q000032:analysis; D000328:Adult; D000368:Aged; D004958:Estradiol / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D008071:Lipoprotein Lipase / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000201:enzymology* / Q000503:physiopathology; D013739:Testosterone / Q000097:blood
D012739:Gonadal Steroid Hormones; D013739:Testosterone; D004958:Estradiol; D006493:Heparin; D008071:Lipoprotein Lipase