On the mechanism of potentiation of apomorphine-induced stereotypy due to electroconvulsive shock.
Electroconvulsive shock-induced changes in the intensity of stereotype induced by apomorphine, the binding of [3H]spiroperidol in the corpus striatum, the accumulation of [3H]dopamine in brain and the permeability of the blood-brain barrier, were monitored in rats 30 min after single, or 24 hr after chronic (once daily for 7 days) electroconvulsive shock. There was significant potentiation in stereotypy induced by apomorphine after chronic electroconvulsive shock. The binding of [3H]spiroperidol did not show any change in the affinity (Kd) or density (Bmax) of receptors in the striatum after acute or chronic electroconvulsive shock. The accumulation of dopamine increased significantly in the hypothalamus after acute electroconvulsive shock and in the corpus striatum and hypothalamus after chronic electroconvulsive shock. A significant increase in the entry of sodium fluorescein into the hypothalamus occurred after acute electroconvulsive shock; it increased in all the regions of the brain after chronic electroconvulsive shock. Alteration in the blood-brain barrier (BBB) by electroconvulsive shock leading to increased accumulation of dopamine in the corpus striatum may be responsible for the potentiation of stereotypy.
Department of Pharmacodynamics, College of Pharmacy, University of Illinois, Chicago 60612.
A
A
Gulati
R C
RC
Srimal
K N
KN
Dhawan
B N
BN
Dhawan
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001812:Blood-Brain Barrier / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004597:Electroshock; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism; D012640:Seizures / Q000523:psychology*; D013134:Spiperone / Q000378:metabolism / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects*
D011954:Receptors, Dopamine; D013134:Spiperone; D001058:Apomorphine; D004298:Dopamine