Use of membrane proteins from Salmonella gallinarum for prevention of fowl typhoid infection in chickens.
Outer membrane protein isolated from Salmonella gallinarum was examined at different concentrations with or without a mineral-oil adjuvant for its immunogenicity and protection against live challenge. A formalin-killed whole-cell bacterin of the same organism was used for comparison. The results suggested that membrane proteins from S. gallinarum give better protection than formalin-killed whole-cell bacterin. Addition of an oil adjuvant to the protein appeared to increase the efficiency of the vaccine. When protein was given to chickens at 400 micrograms/100 g of live body weight, it produced 100% protection against oral challenge with S. gallinarum.
Bouzoubaa
K
K
Institut Agronomique et Veterinaire, Hassan II, Rabat, Institut Morocco.
Nagaraja
K V
KV
Newman
J A
JA
Pomeroy
B S
BS
D000818:Animals; D001425:Bacterial Outer Membrane Proteins; D002645:Chickens; D011201:Poultry Diseases / Q000517:prevention & control*; D012475:Salmonella / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000517:prevention & control*; D014436:Typhoid-Paratyphoid Vaccines; D014611:Vaccination / Q000662:veterinary*
D001425:Bacterial Outer Membrane Proteins; D014436:Typhoid-Paratyphoid Vaccines