Experimental evidence that tryptamine alkaloids do not cause Phalaris aquatica sudden death syndrome in sheep.
The acute toxicity for sheep of 3 alkaloids that occur in Phalaris acquatica was examined by intravenous and oral administration. The lowest tested dose rates that produced clinically observed signs were, for 5-methoxy dimethyltryptamine, 0.1 mg/kg body weight intravenously and 40 mg/kg orally; for gramine, 10 mg/kg intravenously and 500 mg/kg orally; and for hordenine, 20 mg/kg intravenously and 800 mg/kg orally. All induced the clinical signs observed in the nervous form of phalaris toxicity, but none induced the cardiac, sudden death, syndrome.
New South Wales Department of Agriculture, Agricultural Research and Veterinary Centre, Orange.
C A
CA
Bourke
M J
MJ
Carrigan
R J
RJ
Dixon
D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D003645:Death, Sudden / Q000139:chemically induced / Q000662:veterinary*; D005260:Female; D026121:Indole Alkaloids; D008297:Male; D008732:Methoxydimethyltryptamines / Q000633:toxicity*; D010939:Plant Poisoning / Q000662:veterinary; D006109:Poaceae; D012701:Serotonin / Q000031:analogs & derivatives*; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced*; D013577:Syndrome / Q000662:veterinary; D014439:Tyramine / Q000031:analogs & derivatives
D000470:Alkaloids; D026121:Indole Alkaloids; D008732:Methoxydimethyltryptamines; D012701:Serotonin; C007884:gramine; C007964:hordenine; D014439:Tyramine