Correlations between positive and negative aeroions, tissue redox-state potential and heart frequency in rats.
It was observed in rats that following positive aeroionization the redox-state potential (E'0) in skeletal muscles and liver was decreased, and the heart frequency increased. After negative ionization these interrelationships took place inversely. It was also established that upon adding an oxidant (menadione) i.v., the E'0 was decreased (compensatorily) in the organs mentioned above, parallel with the increment of heart frequency. Following injection of reductants (cysteine, thiamine) a reverse image was observed. Applying simultaneously positive ionization and reducing agents, the E'0 change and the heart frequency alteration failed to appear. The phenomenon was the same after simultaneous application of negative ionization and oxidant (menadione) injection. Because the heart effect of positive and negative ionization could readily be prevented by a respective redox agent, it seemed that actions of aeroions are exerted through shifts in tissue E'0. The most probable site of action of E'0, is the pacemaker mechanism, but an action on serotonin liberation may also be assumed.
Central Laboratory of Animal Research, University Medical School, Pécs, Hungary.
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A
Puppi
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P
Práger
I T
IT
Szabó
M
M
Gábriel
M
M
Dely
D000818:Animals; D003545:Cysteine / Q000494:pharmacology; D004594:Electrophysiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007477:Ions; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D051381:Rats; D013831:Thiamine / Q000494:pharmacology; D014812:Vitamin K / Q000494:pharmacology
D007477:Ions; D014812:Vitamin K; D003545:Cysteine; D013831:Thiamine