Absorption of buccal morphine. A comparison with slow-release morphine sulphate.
The absorption of buccal morphine was compared with that of slow-release morphine sulphate in human volunteers. Morphine concentration was assayed by high pressure liquid chromatography in serum samples obtained at intervals up to 8 hours after administration of morphine 20 mg. Similar mean maximum concentrations were obtained by either route, but the mean time to maximum concentration was longer after buccal than after enteral administration.
Pain Relief Unit, King's College Hospital, Denmark Hill, London.
A P
AP
Fisher
C
C
Fung
M
M
Hanna
D000042:Absorption; D000328:Adult; D002610:Cheek; D006801:Humans; D009020:Morphine / Q000097:blood / Q000493:pharmacokinetics*; D009061:Mouth Mucosa / Q000378:metabolism*
D009020:Morphine