Bromocriptine-unresponsive prolactin macroadenoma in a prepubertal female.
Macroprolactinomas occur rarely in prepubertal children. A prepubertal 11 10/12-year-old female with a macroprolactinoma presented with a diagnosis of anorexia nervosa. Findings included severe headaches, anorexia, weight loss, and growth failure. The initial serum prolactin level was 2,916 ng/ml. This value fell after beginning treatment with bromocriptine, but later rose despite a doubling of the dose. Transsphenoidal surgical resection was performed and postoperative radiation given. The use of bromocriptine, surgical resection, and radiation therapy in the treatment of macroprolactinomas are discussed.
Department of Pediatrics, University of Arizona, Tuscon 85724.
K L
KL
Cheyne
E S
ES
Lightner
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GD
Comerci
D000236:Adenoma / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D001971:Bromocriptine / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D010911:Pituitary Neoplasms / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D011388:Prolactin / Q000378:metabolism*; D011628:Puberty, Delayed / Q000209:etiology
D001971:Bromocriptine; D011388:Prolactin