[Convexity meningioma associated with Werner's syndrome--histopathological findings with electron microscopical and immunohistochemical findings].
Werner's syndrome is rare and autosomal recessive condition with multiple progeroid features. There is an increased incidence of neoplasm such as meningioma or sarcoma in association with this syndrome. However, the pathogenesis of this subject is still controversial. To date, only two cases have been reported, dealing with surgical operation. Our present case of a 39-year-old woman who had a meningioma associated with Werner's syndrome is the third of such cases. In this rare case we did histopathological examinations including electron microscopic and immunohistochemical studies, which showed intense proliferation of the connective tissue in the tumor tissue. The present morphological study may imply a close relationship between proliferation of collagen fibers in the meningioma and the aberration of connective tissue metabolism in context of theory of the pathogenesis of Werner's syndrome.
Department of Neurosurgery, Osaka University Medical School, Japan.
K
K
Morimoto
T
T
Yoshimine
Y
Y
Saitoh
M
M
Yamada
H
H
Mogami
S
S
Yamagata
J
J
Miyagawa
D000328:Adult; D003094:Collagen / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008577:Meningeal Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D008579:Meningioma / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D014898:Werner Syndrome / Q000150:complications / Q000378:metabolism / Q000473:pathology*
D003094:Collagen