Regulation of recovery in the erythroid lineage: model studies.
Based on data from the literature, the major regulatory features were established for the erythroid population regenerating after perturbation. A mathematical model is proposed which takes into account: (1) the increase in the proliferating CFU-S due to depopulation of CFU-S and BFU-E/8 pools due to increased migration caused by erythropoietin; (2) regeneration of erythroid precursors due to short-range factors and (3) gradual reduction in the short-range effects and increase in the humoral influence on BFU-E/8, BFU-E/3 and CFU-E together with short-range suppression of progenitor differentiation and acceleration of maturation in all subpopulations due to humoral factors. The kinetics of subpopulations as a function of feedback and maturation rate are analysed. The dependence of erythrocyte production on erythrocyte depletion in the blood and on the feedback coefficient is defined.
Tyazhelova
V G
VG
Institute of Biological Physics, U.S.S.R. Academy of Sciences, Moscow Region.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D004900:Erythroblasts / Q000166:cytology; D004912:Erythrocytes / Q000166:cytology*; D004920:Erythropoiesis; D004921:Erythropoietin / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D007700:Kinetics; D008433:Mathematics; D051379:Mice; D008954:Models, Biological; D013154:Spleen / Q000166:cytology
D004921:Erythropoietin