Recurrent genomic rearrangements are not at the fragile sites on chromosomes 3 and 5 in human renal cell carcinomas.
It has been suggested that fragile sites on human chromosomes predispose to specific rearrangements seen in cancer. Renal cell carcinoma is characterised by recurrent aberrations of chromosome 3p and frequent rearrangements of chromosome 5q. To investigate whether there might be an association between fragile sites and recurrent breakpoints in renal cell carcinoma, we have determined the breakpoints observed in 50 tumours and compared them to the known fragile sites on chromosomes 3 and 5. No correlation between fragile sites and cancer-related breakpoints in renal cell carcinomas was found.
Labor für Tumorcytogenetik, Pathologisches Institut, Medizinische Hochschule, Hannover, Federal Republic of Germany.
G
G
Kovacs
P
P
Brusa
D002292:Carcinoma, Renal Cell / Q000235:genetics*; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D014407:Tumor Cells, Cultured