[Effect of treatment with 1,25-dihydroxyvitamin D3 in children with chronic renal insufficiency].
The effect of 1,25-dihydroxyvitamin-D3 administration on growth rate, renal failure progression and calcium-phosphorus metabolism was evaluated in 8 children younger than 13 years, mean age 6.3 +/- 3.3 (mean +/- SD), with chronic renal failure (glomerular filtration rate: 44.1 +/- 16.5 ml/min/1.73 m2) receiving conservative treatment in whom at least two periods, with a minimal duration of six months each, without and with rocaltrol treatment, could be compared 1.25-dihydroxyvitamin-D3 at dosage of 16.3 +/- 6.3 ng/kg/day resulted in a significant increase (p less than 0.05) of growth index velocity (81.4 +/- 37.8 versus 122.4 +/- 60.3) without altering renal failure progression rate which was assessed by means of 1 to serum creatinine concentration ratio. One hypercalcemic episode (serum calcium equal or greater than 11 mg/dl) every 28.4 months was observed. Our results confirm the beneficial effect of 1.25-dihydroxyvitamin-D3 administration in the management of children with chronic real failure.
Departamento de Pediatría, Hospital Materno-Infantil de la Seguridad Social Nuestra Señora de Covadonga, Facultad de Medicina, Oviedo, Asturias.
C
C
Rey Galaán
I
I
Riaño Galán
A
A
del Molino Anta
F
F
Santos Rodríguez
S
S
Málaga Guerrero
M
M
Crespo Hernández
D002117:Calcitriol / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002657:Child Development / Q000187:drug effects*; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000139:chemically induced*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy*
D002117:Calcitriol
Efecto del tratamiento con 1,25 dihidroxivitamina D3 en niños con insuficiencia renal crónica.