Investigation into the mechanism of copper uptake by Mycoplasma gallisepticum in the presence of 2,9-dimethyl-1,10-phenanthroline.
In the presence of copper certain 2,2'-bipyridyls show antimycoplasmal activity, whereas copper itself causes a toxic effect. In this paper results are presented to elucidate the mechanism of copper uptake in the presence of 2,9-dimethyl-1,10-phenanthroline. The time course of copper and/or ligand uptake under the applied conditions is consistent with a carrier transport mechanism in which 2,9-dimethyl-1,10-phenanthroline operates as a carrier for copper ions. The influence of valinomycin on copper uptake indicates that the transmembrane potential is not the driving force in the carrier process.
Department of Pharmacochemistry, Free University, Amsterdam, The Netherlands.
H D
HD
Gaisser
H
H
van der Goot
A H
AH
Stouthamer
H
H
Timmerman
D001692:Biological Transport / Q000187:drug effects; D002352:Carrier Proteins; D003300:Copper / Q000493:pharmacokinetics*; D008564:Membrane Potentials / Q000187:drug effects; D009174:Mycoplasma / Q000187:drug effects / Q000378:metabolism*; D010618:Phenanthrolines / Q000493:pharmacokinetics / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D014634:Valinomycin / Q000494:pharmacology
D002352:Carrier Proteins; D010618:Phenanthrolines; D014634:Valinomycin; D003300:Copper; C002701:neocuproine; D011188:Potassium