Activation of hepatic glycogenolysis by phagocytic stimulation.
Infusion of latex beads into isolated perfused rat livers transiently increased glucose output, perfusate lactate/pyruvate ratio and portal vein pressure, mimicking hepatic effects of heat-aggregated IgG (HAG). Indomethacin attenuated hepatic responses to latex beads, and extracellular calcium was required for full expression of hepatic responses. Prior infusion of HAG inhibited the glycogenolytic response to latex beads, supporting a common mechanism of action for the two agents.
Department of Radiological Sciences, UCLA School of Medicine, University of California 90024.
D B
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Buxton
D000818:Animals; D007074:Immunoglobulin G; D007213:Indomethacin / Q000494:pharmacology; D007840:Latex; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism*; D010477:Perfusion; D010586:Phagocytes / Q000502:physiology*; D011169:Portal Vein; D051381:Rats; D014690:Venous Pressure / Q000187:drug effects
D007074:Immunoglobulin G; D007840:Latex; D008112:Liver Glycogen; D007213:Indomethacin