Is carbohydrate metabolism genetically related to alcohol drinking?
Ethanol increased significantly the rate of gluconeogenesis from alanine in rats from the AA strain (alcohol-preferring animals), while no change was observed in rats from the ANA strain (alcohol-avoiding animals). The glycogen stores after alcohol administration were depleted in the livers of the ANA rats but remained unaffected in the AA animals. The results indicate that alcohol disturbs the carbohydrate homeostatis in the ANA rats, but not in the AA animals.
Research Laboratories of the State Alcohol Company (Alko, Ltd), Helsinki, Finland.
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D000409:Alanine / Q000378:metabolism; D000428:Alcohol Drinking / Q000502:physiology*; D000818:Animals; D050260:Carbohydrate Metabolism; D005260:Female; D005943:Gluconeogenesis; D008112:Liver Glycogen / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics / Q000378:metabolism
D008112:Liver Glycogen; D000409:Alanine