Enhancing effect of phenobarbital sodium on Tyzzer's disease in mice.
Tyzzer's disease in mice was aggravated by phenobarbital sodium (PB) given consecutively after bacterial inoculation. In PB-treated mice, mortality rate and severity of liver lesions were higher with more prominent bacterial propagation in hepatocytes as compared with non-treated ones, suggesting that PB had an enhancing effect on metabolic activities of host hepatocytes resulting in increased intracellular growth of bacteria.
Xian
M
M
Department of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Japan.
Inoue
S
S
Matsunuma
N
N
Goto
N
N
Fujiwara
K
K
D000818:Animals; D001407:Bacillus; D001424:Bacterial Infections / Q000473:pathology*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology*; D051379:Mice; D008813:Mice, Inbred ICR; D009336:Necrosis; D010634:Phenobarbital / Q000494:pharmacology*
D010634:Phenobarbital