Chemoprophylactic studies with ivermectin against subperiodic Brugia malayi infection in the leaf monkey, Presbytis cristata.
Four Presbytis cristata were treated with oral ivermectin at the same time as the subcutaneous inoculation of 100 infective larvae monthly for three months. Two animals given 0.2 mg/kg monthly and two others given 0.3 mg/kg monthly as well as three control animals became patent for microfilaraemia. However, only 1% of the infective dose was recovered as adult worms from animals in the higher drug dosage group compared to 8.2% and 6.2% in the lower dosage and control groups respectively.
Mak
J W
JW
Institute for Medical Research, Jalan Pahang, Kuala Lumpur, Malaysia.
Lam
P L
PL
Rain
A N
AN
Suresh
K
K
D000818:Animals; D002009:Brugia; D002520:Cercopithecidae; D004605:Elephantiasis, Filarial / Q000517:prevention & control*; D005260:Female; D005368:Filariasis / Q000517:prevention & control*; D007559:Ivermectin / Q000627:therapeutic use*; D008297:Male; D011897:Random Allocation
D007559:Ivermectin