[Participation of the dopaminergic system in the immune response-stimulating effect of muramyl dipeptide].
It has been shown that administration of muramyl dipeptide (MDP) in a dose of 1 mg/kg simultaneously with SRBC (5 x 10(6) immunization resulted in a considerable increase of immune response. Stimulation of the immune response is prevented by preliminary blockade of dopamine receptors with haloperidol, that testifies to the activation of the dopaminergic system by certain MDP dosages.
Al'perina
E L
EL
Zidek
Z
Z
Idova
G V
GV
Devoĭno
L V
LV
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D007016:Hypophysectomy; D007114:Immunization; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010902:Pituitary Gland / Q000187:drug effects / Q000276:immunology; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000276:immunology; D012397:Rosette Formation
D011954:Receptors, Dopamine; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D006220:Haloperidol
Uchastie dofaminergicheskoĭ sistemy v stimuliruiushchem immunnyĭ otvet éffekte muramildipeptida.