The effects of phenylpropanolamine on food intake and body weight in the genetically obese (ob/ob) mouse.
The purpose of the present study was to compare the actions of the anorexigen phenylpropanolamine (PPA) on chronic feeding and body weight in lean and in genetically obese mice. Adult (8-week-old) female C57BL/6J ob/ob mice and female +/? lean control mice were treated (i.p.) twice daily (at 0800 hrs and 2000 hrs) for 21 days with either 0.9% saline or with 10 or 20 mg/kg PPA. Analyses of cumulative 72-hour food intake revealed that PPA induced significant and dose-dependent anorexia in ob/ob mice but that PPA was without significant anorectic effect in lean mice. PPA dose levels of 10 mg/kg and 20 mg/kg reduced food intake in ob/ob mice by 14 and 21%, but reduced food intake in lean mice by only 3 and 6%, respectively. Analyses of body weight, however, did not reveal significant changes in body weight induced by either PPA dose in ob/ob or lean mice. The enhanced anorexic effects induced by PPA and other adrenergic agents in the ob/ob mouse are discussed.
Department of Psychology, Texas A&M University, College Station 77843.
P J
PJ
Wellman
J
J
Miller
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000503:physiopathology*; D010665:Phenylpropanolamine / Q000494:pharmacology*
D010665:Phenylpropanolamine