Pedal hemangioma (venous malformation) occurring in Turner's syndrome: an additional manifestation of the syndrome.
Two infants with Turner's syndrome and an unusual vascular tumor or malformation of the feet are described. In one child, the lesion developed in the dorsal metacarpal area, whereas in the other, the lesion was located in a bilaterally symmetrical distribution over the dorsum of the feet. Both lesions were characterized by a proliferation of tortuous, thick-walled veins with imperfectly formed muscular walls. Redundancy of the endothelial lining leading to intimal "webs" and intraluminal vascular channels was prominent. The similarity of these two lesions clinically and histologically suggests that they do not represent a fortuitous occurrence, but an additional manifestation of Turner's syndrome. Furthermore, their existence indicates that the vascular abnormality in Turner's syndrome may be more generalized than previously recognized and may include abnormalities of peripheral blood vessels in addition to those of the heart and aorta.
Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000.
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Weiss
D005534:Foot Diseases / Q000209:etiology / Q000473:pathology*; D006391:Hemangioma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D014424:Turner Syndrome / Q000150:complications / Q000473:pathology*