A model for sidewall adhesions in the rabbit: reduction by an absorbable barrier.
Despite use of surgical adjuvants, pelvic adhesions frequently develop following infertility surgery. Recently a resorbable biocompatible material, TC 7, has been designed to be used as a barrier to reduce adhesion formation. Reproducibly severe sidewall adhesions were only able to be created in one of six models tested. The model consisted of the following steps: excision of a full thickness 2 x 2-cm musculoperitoneal tissue mass, scraping of an adjacent 2-cm length of uterine horn, tamponading of all bleeding, and suturing (6-0 Vicryl) of normal tube and sidewall so as to directly approximate the traumatized tissues. Studies were conducted in 13 rabbits after creation of the bilateral sidewall and horn lesions, each serving as its own control. Choice of control and TC 7 sides was determined randomly. Adhesion formation was examined 2 weeks postoperatively. No residual material was noted at that time. Adhesion scores were the composite total of extent (0-4), type (0-4), and tenacity (0-3) of sidewall adhesions, and were significantly reduced on the TC 7 side as compared with the control side (mean 6.8 +/- 0.4 vs 9.0 +/- 0.3, median 6 vs 9, sign test P = 0.0032). No complications of use of the barrier were noted. It is concluded that use of TC 7, a resorbable biocompatible barrier, was able to significantly reduce postoperative adhesion formation on the rabbit sidewall.
Department of Obstetrics and Gynecology, Yale University Medical Center, New Haven, Connecticut 06510.
M P
MP
Diamond
C B
CB
Linsky
T
T
Cunningham
B
B
Constantine
G S
GS
diZerega
A H
AH
DeCherney
D000818:Animals; D001672:Biocompatible Materials; D002482:Cellulose; D005260:Female; D005500:Follow-Up Studies; D010388:Pelvis / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D013537:Sutures; D000267:Tissue Adhesions / Q000517:prevention & control*
D001672:Biocompatible Materials; D002482:Cellulose