Platelet storage lesion: formation of platelet fragments with platelet factor 3 activity.
Certain samples of stored platelet concentrates exhibited marked platelet factor 3 activity. This activity was associated almost completely with platelet fragments formed during storage. Platelet concentrates containing high levels of these fragments and hence high platelet factor 3 activity were characterized after storage by alkaline plasma pH values, high levels of extracellular lactate dehydrogenase activity and relatively low cell counts.
Institute of Medical Biology, University of Tromsø, Norway.
C
C
Solberg
B
B
Osterud
C
C
Little
D001792:Blood Platelets / Q000378:metabolism* / Q000648:ultrastructure; D001793:Blood Preservation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007770:L-Lactate Dehydrogenase / Q000097:blood; D010976:Platelet Count; D013925:Thromboplastin / Q000378:metabolism*
D013925:Thromboplastin; D007770:L-Lactate Dehydrogenase