[Synthesis and antitumor properties of 3'-desamino-3'-dimethylformamidinorubomycin].
Interaction of rubomycin (daunorubicin) chlorhydrate with dimethylformamidine diethyl acetal yielded 3'-desamino-3'dimethylformamidinorubomycin chlorhydrate (DFR). Comparative antitumor activity of DFR and rubomycin was studied on mice with respect to ascitic lymphadenosis NK/Ly and Ehrlich carcinoma, hemocytoblastosis La, leukemia P-388 and two solid tumors i. e. lymphosarcoma LIO-I and sarcoma 180. The highest antitumor effect of DFR was observed in the mice with Ehrlich carcinoma and lymphadenosis NK/Ly after the drug intravenous administration for 4 times. By selectivity of the antitumor effect DFR was inferior to rubomycin with respect to lymphosarcoma LIO-I and sarcoma 180. It was shown that the antileukemic activity of DFR and rubomycin with respect to hemocytoblastosis La was practically the same. In the experiments with leukemia P-388 DFR was inferior to rubomycin.
Povarov
L S
LS
Ul'ianova
L A
LA
Tarasova
V E
VE
Odnoralets
E N
EN
Iudina
O I
OI
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D007928:Lethal Dose 50; D007942:Leukemia, Experimental / Q000188:drug therapy; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy
C057110:3'-desamino-3'-dimethylformamidine rubomycin; D003630:Daunorubicin
Sintez i protivoopukholevye svoĭstva 3'-dezamino-3'-dimetilformamidinorubomitsina.