The effect of oral adsorbent on surgically induced hepatic failure.
The oral adsorbent AST-120 is one type of activated carbon for oral use. In the present study, AST-120 was administered, to clarify its effect, on surgically induced hepatic failure in dogs and rats. Portacaval shunts and varying extents of hepatectomies were performed on 44 dogs. Eleven dogs were given an ordinary diet (control group), and 33 dogs received the oral adsorbent with an ordinary diet after the operation (AST group). Plasma bile acids and ammonia increased, and body weight decreased in both groups. However, after the administration of AST-120, the plasma bile acids and ammonia decreased significantly, and the body weight tended to increase in the AST group. Portacaval shunts and about 70 per cent hepatectomy were performed on 59 Sprague-Dawley rats. These rats were divided into two groups, diet with the oral adsorbent (AST group, n = 19) and an ordinary diet alone (control group, n = 40). DNA synthesis and protein synthesis of the liver were measured on the 5th, 10th and 20th postoperative days using radioisotopes in these rats. Both DNA and protein synthesis of the liver were increased significantly in the AST group. Histological examination revealed many more glycogen granules in the cytoplasm of hepatocytes in the AST group compared to the control group on the 5th postoperative day. It was suggested that some metabolic toxin was adsorbed by AST-120 in the alimentary tract.
Second Department of Surgery, Faculty of Medicine, University of Tokyo, Japan.
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Hiraishi
D000327:Adsorption; D000596:Amino Acids / Q000097:blood; D000641:Ammonia / Q000097:blood; D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood; D001835:Body Weight; D002244:Carbon / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004285:Dogs; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000628:therapy*; D008297:Male; D010087:Oxides / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D001647:Bile Acids and Salts; D010087:Oxides; D002244:Carbon; D000641:Ammonia; C040896:AST 120