Effect of chronic chloroquine treatment on prostaglandin and human chorionic gonadotropin (hCG) stimulation of testosterone secretion by the rat testis.
The effect of chronic chloroquine administration on prostaglandin E1 (PGE1) and human chorionic gonadotropin (hCG) stimulation of testosterone secretion by the rat Leydig cells was studied. Adult albino (Wistar strain) rats were injected with 4 mg/kg body weight of chloroquine phosphate every other day for 30 days. At the end of the period of treatment, the rats were sacrificed and the Leydig cells incubated with hCG and/or PGE1 for 3 hrs. The amount of testosterone secreted was estimated by radioimmunoassay. Chronic chloroquine treatment did not affect the activity of the Leydig cells and combined PGE1 and hCG did not show any additive effects.
Department of Chemical Pathology, College of Medicine, University of Ibadan, Nigeria.
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Nduka
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Dada
D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D013739:Testosterone; D002738:Chloroquine; D000527:Alprostadil