Retinal toxicity of cyanoacrylate tissue adhesive in the rabbit.
N-butyl-2-cyanoacrylate tissue adhesive was injected into the preretinal space of rabbit eyes to study potential toxicity to the retina. Application of 3.3-10.0 ul of cyanoacrylate tissue adhesive showed localized but definite retinal toxicity. White halos appeared surrounding the preretinal cyanoacrylate immediately after injection with a gradual evolution of the white areas into pigmentary scars by 1 month. Histological examination confirmed severe focal necrosis of the retina. No identifiable distant toxic effects or electrophysiologic changes were observed during the 6-month follow-up period.
Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, Durham 27710.
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Hida
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Sheta
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Proia
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McCuen
D000818:Animals; D001831:Body Temperature; D003487:Cyanoacrylates / Q000633:toxicity*; D004596:Electroretinography; D005500:Follow-Up Studies; D009336:Necrosis; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D014014:Tissue Adhesives / Q000633:toxicity*
D003487:Cyanoacrylates; D014014:Tissue Adhesives