[Drug-induced hepatitis after dihydralazine treatment with fatal consequences].
Adverse drug side effects of the antihypertensive substance dihydralazine have been increasingly observed in recent years. Damage is concentrated on the liver and is characterized by drug-induced hepatitis with confluent necrosis. Three cases (60 year old woman, 79 year old woman, 61 year old man) with lethal course after antihypertensive treatment, using dihydralazine are reported in this paper.
Institut für Pathologische Anatomie, Friedrich-Schiller-Universität Jena.
G
G
Machnik
A
A
Bergert
J
J
Justus
P
P
Kunze
R
R
Müller
M
M
Reinhardt
H
H
Schulz
G
G
Stein
R
R
Thiele
D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D004078:Dihydralazine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis
D006830:Hydralazine; D004078:Dihydralazine
Arzneimittelhepatitis nach Dihydralazin mit tödlichem Verlauf.