Long-term stability in vivo of a thromboresistant heparinized surface.
A surface with covalently bonded heparin was tested in an in vivo model. Heparinized and non-heparinized tubings were inserted in the pig aorta. They were left in place for up to 16 wk. After removal they were analysed for their capacity to take up and inhibit thrombin. A comparison was also made with tubings that had not been inserted in animals. The heparin surface showed some specific alterations after implantation but its capacity to inhibit thrombin was not impaired. The heparinized tubings caused less intimal hyperplasia and thrombi than non-heparinized tubings.
Arnander
C
C
Department of Experimental Surgery, Karolinska Institute, Stockholm, Sweden.
Bagger-Sjöbäck
D
D
Frebelius
S
S
Larsson
R
R
Swedenborg
J
J
D000818:Animals; D001011:Aorta / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D002417:Cattle; D006493:Heparin; D008855:Microscopy, Electron, Scanning; D011485:Protein Binding; D013552:Swine; D013917:Thrombin / Q000378:metabolism*
D006493:Heparin; D013917:Thrombin