Metallothionein induction by cadmium and zinc in rat secretory organs.
Metallothionein (MT) levels were determined in four secretory organs of the rat following administration of zinc (Zn) and cadmium (Cd). The concentrations of MT in the lacrimal, parotid and adrenal glands of untreated rats were in the range of 2.2-4.9 micrograms/g wet weight tissue while in the pancreas it was shown to be 15.2 micrograms/g. Injection of zinc at total doses of 16, 32 and 80 mg/kg resulted in a 1.8-, 3.2- and 5.9-fold increase in lacrimal MT content, respectively, while a 10.2- and 13.1-fold elevation was observed following treatment with 4 and 8 mg/kg of Cd, respectively. Similar findings were found in the adrenal gland. The parotid MT was elevated 5.9 and 17 times following Zn treatment at doses of 16 and 80 mg/kg respectively, whereas 4 mg/kg of Cd increased MT 14.4 times in this gland. Pancreatic MT was elevated by 39- and 40-fold after injection of Zn at doses of 16 and 32 mg/kg respectively, whereas 4 and 8 mg/kg of Cd caused a 9.8- and 17.9-fold induction, respectively. These results may indicate that secretory organs participate in metabolism of heavy metals in the mammalian body.
Department of Pharmacology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
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Wormser
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Calp
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D007765:Lacrimal Apparatus / Q000378:metabolism; D008668:Metallothionein / Q000096:biosynthesis*; D010179:Pancreas / Q000378:metabolism; D010306:Parotid Gland / Q000378:metabolism; D051381:Rats; D015032:Zinc / Q000494:pharmacology*
D002104:Cadmium; D008668:Metallothionein; D015032:Zinc