Augmentation of mitogen responsiveness in the aged by a special lipid diet AL 721.
Diminished immune responses in aging may be partially due to alteration of the lipid composition of membrane and a decrease in membrane fluidity. The effect of a daily diet of 10 g active lipid (AL 721) on the mitogen responsiveness of peripheral blood mononuclear cells (PBMC) from aged volunteers was studied. AL 721 is a mixture of lipids from hen egg yolk which was formulated for in vivo rectification of rigidified cell membranes in an attempt to restore proper physiological function. After 3 weeks on the diet, six aged participants displayed a significant increase in lymphocyte responsiveness to mitogens, while in four the responsiveness was unaffected, or increased insignificantly. In all six participants, a decline in lymphocyte responsiveness was observed a week after termination of the diet. Our preliminary results indicate that improvement of immune functions in the aged may be achieved by dietary manipulation of lipids. This innocuous approach seems to be of potential value and merits further studies.
Rabinowich
H
H
Laboratory of Clinical Immunology, Sackler Medical School, Tel-Aviv University, Meir General Hospital, Kfar Saba, Israel.
Lyte
M
M
Steiner
Z
Z
Klajman
A
A
Shinitzky
M
M
D000368:Aged; D000369:Aged, 80 and over; D002478:Cells, Cultured; D004041:Dietary Fats; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D005989:Glycerides / Q000494:pharmacology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D008297:Male; D008934:Mitogens; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010714:Phosphatidylethanolamines / Q000494:pharmacology*
D004041:Dietary Fats; D004338:Drug Combinations; D005989:Glycerides; D008934:Mitogens; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; C046637:neutral lipid, phosphatidylcholine, phosphatidylethanolamine drug combination