Formyl peptide chemoattractants. Synthesis and chemotactic activity.
The tetrapeptides CHO-Met-Leu-Phe-CO-NH-(CH2)n-COOMe (n = 1-5) have been synthesized. These peptides containing an omega-amino acid residue in position 4 exhibit a very high chemotactic activity. Like the chemotactic peptide CHO-Met-Leu-Phe-OMe, these tetrapeptides in solution undoubtedly adopt an "active" conformation which allows a strong interaction with the receptor on the human polymorphonuclear leukocyte surface.
Falcomer
C
C
Department of Pharmaceutical Sciences, University of Ferrara, Italy.
Vertuani
G
G
Boggian
M
M
Scatturin
A
A
Spisani
S
S
Cavalletti
T
T
Traniello
S
S
D002465:Cell Movement / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002630:Chemotactic Factors / Q000138:chemical synthesis* / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008968:Molecular Conformation; D009504:Neutrophils / Q000187:drug effects; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D002630:Chemotactic Factors; D009842:Oligopeptides