[2-Amino-oxazoles as potential bonding agents in virostatic research. 1. N-unsubstituted and n-substituted 2-amino-oxazoles].
2-Amino-oxazoles with the semicyclic amidine structure are able in principle to form hydrogen bonds with native components for example with viral nucleic acids or viral enzymes. In this way the inhibition of viral replication seems to be possible. The syntheses of 39 compounds with amidine structure are described and the results of the antiviral agar diffusion plaque inhibition test are discussed in relation to the chemical structures.
Zentralinstitut für Mikrobiologie und experimentelle Therapie, Akademie der Wissenschaften der DDR, Jena.
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D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D010080:Oxazoles / Q000138:chemical synthesis*; D014780:Viruses / Q000187:drug effects
D000998:Antiviral Agents; D010080:Oxazoles
2-Amino-oxazole als potentielle H-Brückenbilder in der Virostaticaforschung. 1. Mitteilung: N-Unsubstituierte und N-substituierte 2-Amino-oxazole.