[Serum and cerebrospinal fluid levels after high dose of etoposide administrated intravenously].
Seric values have been evaluated in 24 patients receiving high doses of etoposide. In 6 patients, CNS value was evaluated simultaneously. After 2 perfusions with 250 mg/m2 at 12 h interval, seric value is 35.3 micrograms/ml + 10.3, the value after 6 perfusions is 31.1 micrograms/ml + 6.5. The variation of CNS value observed from 0.08 to 0.49 micrograms/ml is 0.36 to 1.29% of the seric value; there is no positive correlation with seric value. Only one patient out of 6 has a partial response of CNS metastases.
Hôpital Salvator, Marseille, France.
J P
JP
Kleisbauer
N
N
Lena-Nosny
D
D
Vesco
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000556:secondary; D005047:Etoposide / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged
D005047:Etoposide
Taux sériques et taux dans le liquide céphalo-rachidien après forte dose d'étoposide administrée par voie intraveineuse.