[Changes in the gangliosides of erythrocyte membranes of schizophrenic patients].
The pattern of gangliosides in membranes of erythrocytes was examined in healthy donors, in acute schizophrenics without neuroleptic treatment and in alcohol-dependent patients. 7 different gangliosides could be detected after extraction, purification by column chromatography and fractionation by TLC. Healthy donors were characterized by the following pattern of gangliosides: GX = 5.8%, GT1b = 6.7%, FucGD1b = 5.2%, und GD1a = 12.6%, GD3 = 9.2%, SPG = 43.5% and GM3 = 17.0%. In schizophrenic patients the GM3- and GD3-fraction were increased. No difference was found between the control group and the alcoholics.
Institut für Pathologische Biochemie, Medizinischen Akademie Magdeburg.
U
U
Haselhorst
H
H
Schenk
I
I
Beyer
R
R
Uebelhack
L
L
Franke
V
V
Kielstein
D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000097:blood; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D005732:Gangliosides / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood*
D005732:Gangliosides
Veränderungen der Ganglioside von Erythrozytenmembranen schizophrener Patienten.