Radioreceptor assay in checking serum concentration in long-term treatment with cis(z)-flupenthixol decanoate.
24 patients have been treated with cis(z)-flupenthixol decanoate for 6-12 months. Intramuscular injections were given about every 3 weeks. Before treatment and on each day of injection the mental state was assessed by BPRS and registration of side effects was performed. Blood samples were taken 7 days after each injection and on the last day of the dosage interval. Neuroleptic activity was determined in serum by RRA and expressed in cis(z)-flupenthixol equivalents. The drug level was significantly correlated to the dose. No clear relationship between drug level and clinical results as well as side effects was found. Less pronounced variations of the drug level between subsequent injections resulted in a positive therapeutic response.
Department of Biochemistry, Institute of Psychiatry and Neurology, Warsaw, Poland.
B
B
Lipska
L
L
Welbel
K
K
Nurowska
B
B
Szukalski
D000328:Adult; D005260:Female; D005475:Flupenthixol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood* / Q000627:therapeutic use; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D011869:Radioligand Assay; D012559:Schizophrenia / Q000188:drug therapy*; D013892:Thioxanthenes / Q000097:blood*
D013892:Thioxanthenes; C007761:flupenthixol decanoate; D005475:Flupenthixol