Short-term stimulation of lymphocyte proliferation by indomethacin in vitro and in vivo.
The effect of short-term (up to 24 h) in vitro and in vivo treatment with indomethacin was studied on the blastogenesis of mouse spleen cells. Indomethacin in itself induced a strong proliferation of the lymphocytes starting after 6 h treatment both in vitro and in vivo. Besides, significantly enhanced the blastogenesis of splenocytes in response to various doses of PHA and Con A. The stimulation of lectin-induced lymphocyte proliferation occurred after indomethacin treatment both in vitro and in vivo. Indomethacin had no major effect on the distribution of Lyt-1+ and Lyt-2+ subsets within the spleen cell population. An important role of the prostaglandins in the early phase of lymphocyte activation is suggested.
Second Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
R
R
González-Cabello
A
A
Perl
L
L
Kalmár
P
P
Gergely
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010641:Phenotype; D010835:Phytohemagglutinins / Q000494:pharmacology; D013154:Spleen / Q000166:cytology
D010835:Phytohemagglutinins; D003208:Concanavalin A; D007213:Indomethacin