Incidence of endogenous and exogenous opportunistic fungal infections in relation to different prophylactic measures: clinical and microbiological study of 431 immunocompromised patients.
Two groups of immunocompromised patients were studied with the aim of pointing out the possibilities of antifungal prophylaxis in this type of patient. All patients received oral treatment with nystatin, but only the patients of one group were also in strict reverse isolation. It has been confirmed that chemoprophylactic treatments may control opportunistic endogenous mycoses effectually. On the contrary, only reverse isolation seems to be effective against airborne exogenous fungal infections. Because of the difficulty and high cost of this practice, different modalities for a really generalizable antifungal prophylaxis are required. At present only the detection of new systemic antifungal drugs, which are not toxic and are easy to use, seems hopeful.
Institute of Microbiology, Policlinico S. Orsola, Bologna, Italy.
A
A
Mazzoni
M
M
Fiacchini
R
R
Cevenini
M
M
Gatti
A
A
Nanetti
D005658:Fungi / Q000302:isolation & purification; D006801:Humans; D007108:Immune Tolerance; D009181:Mycoses / Q000517:prevention & control*; D009761:Nystatin / Q000627:therapeutic use*; D009894:Opportunistic Infections / Q000517:prevention & control*; D010356:Patient Isolation
D009761:Nystatin