[Amplification of regions of the genome in the somatic cells of mammals resistant to colchicine. VII. Localization of the initial and amplified copies of gene mdr in one and the same segment of chromosome 4 of the Djungarian hamster].
By in situ hybridization technique, the mdr gene which is amplified during the development of multiple drug resistance was mapped in the 4q15--21 segment of normal Djungarian hamster chromosome 4. As was shown earlier, this chromosomal region is specific for the location of amplified mdr gene copies. These results, as well as some data obtained by other authors, suggest that recombinations of amplified DNAs occur preferentially in or near the sites bearing homologous sequences.
O I
OI
Sokova
E Iu
EIu
Siianova
A V
AV
Gudkov
B P
BP
Kopnin
D000818:Animals; D002478:Cells, Cultured; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002875:Chromosomes / Q000648:ultrastructure*; D003078:Colchicine / Q000037:antagonists & inhibitors*; D006224:Cricetinae / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics; D005784:Gene Amplification; D005796:Genes; D007621:Karyotyping; D008677:Metaphase; D009693:Nucleic Acid Hybridization; D011544:Pseudogenes
D003078:Colchicine
Amplifikatsiia uchastkov genoma v somaticheskikh kletkakh mlekopitaiushchikh, ustoĭchivykh k kolkhitsinu. Soobshchenie VII. Lokalizatsiia iskhodnoĭ i amplifitsirovannykh kopiĭ gena mdr v odnom i tom zhe segmente khromosomy 4 dzhungarskogo khomiachka.