Inhibitors of sterol synthesis. Synthesis and spectral characterization of fatty acids esters of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one.
Reported herein are the chemical syntheses of 29 fatty acid esters of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one. These compounds were characterized by the results of ultraviolet, 1H nuclear magnetic resonance, and mass spectral studies.
St Pyrek
J
J
Department of Biochemistry, Rice University, Houston, TX 77251.
Schroepfer
G J
GJ
D055598:Chemical Phenomena; D002621:Chemistry; D002782:Cholestenes / Q000138:chemical synthesis*; D002783:Cholestenones / Q000032:analysis / Q000138:chemical synthesis*; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013056:Spectrophotometry, Ultraviolet; D013261:Sterols / Q000096:biosynthesis*
D002782:Cholestenes; D002783:Cholestenones; D013261:Sterols; C015073:cholest-8(14)-en-3-ol-15-one