A set of monozygotic twins with Rett syndrome.
The case history of a set of twins with Rett syndrome is presented. The twins test as monozygotic by both blood groups and HLA titers. In a previous generation, the family had three females who died of an unknown degenerative disease on the paternal side of this family. The discussion includes a hypothesis about female genetic disease occurring in a recessive pattern on the X chromosome.
Georgetown University School of Medicine, Washington, DC.
M
M
Coleman
S
S
Naidu
M
M
Murphy
M
M
Pines
W
W
Bias
D001927:Brain Diseases / Q000235:genetics*; D002648:Child; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D010375:Pedigree; D013577:Syndrome; D014430:Twins, Monozygotic; D014960:X Chromosome