Space-based abstinence: alleviation of withdrawal symptoms in combinative cocaine-phencyclidine abuse.
Twenty male combinative cocaine free-base/phencyclidine (space-base) abusers were studied for forty-five days, in a double-blind design. Treatment with desipramine was significantly more effective than placebo in alleviating abstinence symptoms. This study tends to support the catecholamine-depletion hypothesis of cocaine and phencyclidine withdrawal.
Giannini
A J
AJ
Northeast Ohio Medical College, Ohio State University, Youngstown.
Loiselle
R H
RH
Giannini
M C
MC
D000328:Adult; D003042:Cocaine / Q000009:adverse effects*; D003891:Desipramine / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D010622:Phencyclidine / Q000009:adverse effects*; D011614:Psychotherapy, Brief; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D003042:Cocaine; D010622:Phencyclidine; D003891:Desipramine