Di-(2-ethylhexyl)-phthalate as plasticizer in PVC respiratory tubing systems: indications of hazardous effects on pulmonary function in mechanically ventilated, preterm infants.
Several PVC medical devices contain the plasticizer Di-(2-ethylhexyl)-phthalate (DEHP) in high concentration. Taken systematically DEHP only has minor toxic effects in the human organism. In three preterm infants artificially ventilated with PVC respiratory tubes unusual lung disorders resembling those observed in hyaline membrane disease, verified both clinically and radiologically, were observed during the fourth week of life. It was assumed that these lung disorders were causally related to the exposure to high doses of DEHP, which was released from the walls of the respiratory tubes. DEHP was found in the lung tissue of one patient who died of pneumothorax soon after birth after being artificially ventilated. It is strongly recommended that for disposable PVC respiratory devices the plasticizer DEHP should be used with more restrictions.
Universitäts-Kinderklinik, Köln, Federal Republic of Germany.
B
B
Roth
P
P
Herkenrath
H J
HJ
Lehmann
H D
HD
Ohles
H J
HJ
Hömig
G
G
Benz-Bohm
J
J
Kreuder
A
A
Younossi-Hartenstein
D004051:Diethylhexyl Phthalate / Q000009:adverse effects* / Q000032:analysis; D004869:Equipment Safety; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000032:analysis; D008297:Male; D010795:Phthalic Acids / Q000009:adverse effects*; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D012122:Ventilators, Mechanical / Q000009:adverse effects*
D010795:Phthalic Acids; D004051:Diethylhexyl Phthalate