Allergenic agent in contact dermatitis from Holigarna ferruginea.
9 of 10 patients who developed dermatitis following contact with Holigarna ferruginea and 5 of 35 asymptomatic volunteers showed a positive patch test reaction to 2% W/V acetone extract of the plant's resinous exudate. 6 albino rats were sensitized following 3 weekly applications of the same extract. Laccol (3-heptadecadienyl catechol) was identified as the active principle in the exudate.
Srinivas
C R
CR
Department of Skin & STD, Kasturba Medical College and Hospital, Manipal, India.
Kulkarni
S B
SB
Menon
S K
SK
Krupashankar
D S
DS
Iyengar
M A
MA
Singh
K K
KK
Sequeira
R P
RP
Holla
K R
KR
D000328:Adult; D000368:Aged; D000818:Animals; D002396:Catechols / Q000506:poisoning*; D002648:Child; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D010328:Patch Tests; D010939:Plant Poisoning / Q000150:complications*; D051381:Rats
D002396:Catechols; C054650:3-heptadecadienyl pyrocatechol