[Nonsteroidal anti-inflammatory agents. V. Synthesis of 1-aryl-5-(1-pyrryl)-pyrazolyl-4-acetic acids with potential anti-inflammatory action].
The synthesis of 1-aryl-5-(1-pyrryl)pyrazoles bearing at position 4 an acetic or alpha-propionic chain is described. The new compounds can be structurally related to lonazolac and its analogues with analgesic-antiinflammatory activities. When tested pharmacologically in comparison with tolmetin and indomethacin none of the above derivatives showed any appreciable activity.
Dipartimento di Studi Farmaceutici, Facolta' di Farmacia, Universita' di Roma La Sapienza.
F
F
Corelli
S
S
Massa
G
G
Stefancich
R
R
Silvestri
M
M
Artico
G C
GC
Pantaleoni
G
G
Palumbo
D
D
Fanini
R
R
Giorgi
D000085:Acetates / Q000138:chemical synthesis*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles
Agenti antiinfiammatori non-steroidei. Nota V. Sintesi di acidi 1-aril-5-(1-pirril)pirazolil-4-acetici a potenziale attività antiinfiammatoria.