Hyaluronidase treatment of synovial fluid affects the recovery of mononuclear cells and their in vitro immunoglobulin synthesis.
Treatment of arthritic synovial fluid with hyaluronidase reduced the recovery of mononuclear cells as well as their in vitro IgA and IgG synthesis. Hyaluronidase should be avoided in the treatment of synovial fluid when unselected mononuclear cell populations are required.
Geborek
P
P
Department of Rheumatology, University Hospital, Lund, Sweden.
Truedsson
L
L
Sandberg
M
M
Wollheim
F A
FA
D001171:Arthritis, Juvenile / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology*; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D013582:Synovial Fluid / Q000166:cytology* / Q000276:immunology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D006821:Hyaluronoglucosaminidase