[Effect of tamponade on the nucleotide composition and cytosine methylation level of DNA in the heart muscle of dogs].
Base composition and quantitative changes in the 5-methylcytosine (m5c) content in DNA isolated from male dogs' heart muscle under the acute tamponade have been studied. Due to the effect of tamponade statistically reliable decrease (15%) in m5c content in DNA has been found to take place in experiment in comparison with control. Possible mechanisms of DNA methylation decrease by cytosine are under discussion.
Kliasheva
R I
RI
Vasil'ev
Zh Kh
ZhKh
Ivanova
Z I
ZI
D044503:5-Methylcytosine; D000208:Acute Disease; D000818:Animals; D002305:Cardiac Tamponade / Q000378:metabolism*; D003596:Cytosine / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism*; D004247:DNA / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology; D008297:Male; D008745:Methylation; D009206:Myocardium / Q000032:analysis / Q000378:metabolism*; D009711:Nucleotides / Q000032:analysis / Q000378:metabolism*
D009711:Nucleotides; D044503:5-Methylcytosine; D003596:Cytosine; D004247:DNA; D004837:Epinephrine
Vliianie tamponady na nukleotidnyĭ sostav i uroven' metilirovaniia tsitozina DNK v myshtse serdtsa sobak.