[Biochemical and histological research on lung tissue in experimental carbon disulfide exposure].
During an experiment on two species of test animals (guinea pigs and white male rats) is studied the effect of carbon sulfide on the biochemical and structural characteristic of the lung. Duration of the experiments 30 days with guinea pigs and 90 days-white male rats. A complex of biochemical and histological methods is applied. Disturbances in the metabolic processes of the lung are established: a) raised activity of the hydrolytic enzymes; b) increased activity of the glycolytic enzymes and c) stronger protein synthesis. The observed metabolic disturbances are based, most probably, on the circulation infringements, occurring in the lung tissue under the effect of carbon sulfide.
Mikhaĭlova
A
A
Petrova
S
S
Donchev
N
N
D000280:Administration, Inhalation; D000818:Animals; D002246:Carbon Disulfide / Q000633:toxicity*; D006168:Guinea Pigs; D008168:Lung / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012995:Solubility; D013438:Sulfhydryl Compounds / Q000378:metabolism
D011506:Proteins; D013438:Sulfhydryl Compounds; D002246:Carbon Disulfide
Biokhimichni i khistologichni izsledvaniia na belodrobnata tŭkan pri eksperimentalna ekspozitsiia na serovŭglerod.