Cerebral metastases from choriocarcinoma. Results of chemotherapy.
Of 36 cases of choriocarcinoma treated at the University Hospital Kuala Lumpur during 1980-84 inclusive, 6 patients were found to have cerebral metastases. Intrathecal methotrexate and combination chemotherapy were started in all cases, with monitoring of tumor growth by serial beta-HCG assays and CT scanning of brain and lung. Chemotherapy was reduced because of severe toxicity in 2 patients, one of whom received radiotherapy to the brain. Four patients (66%) have now been in remission for 2.5-6 years. Two did not respond to therapy and died. The factors involved in therapy and response are discussed.
Sen
D K
DK
Department of Obstetrics and Gynaecology, University Hospital, Kuala Lumpur, Malaysia.
Sivanesaratnam
V
V
Chuah
C Y
CY
Ch'ng
S L
SL
Singh
J
J
Paramsothy
M
M
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000556:secondary*; D002822:Choriocarcinoma / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000401:mortality
D006063:Chorionic Gonadotropin; D008727:Methotrexate