Animal model of cardiotoxicity: carbon monoxide induced ECG hypoxia masked in light narcosis.
Inhalation exposure of restrained conscious rats to carbon monoxide (1000 ppm, 120 min.) led to a peak carboxyhaemoglobine concentration of 40-45%. At this concentrations spontaneous motor activity was not affected significantly but the physical capacity at endurance run was depressed by 70%. From the 30th min. of exposure a typical two-phasic change in heart rate with initial tachycardia and obvious but unstable hypoxic changes in ECG were observed. Quieting of animals (light anesthesia with phenobarbitone; 100 mg/kg ip) removed almost completely all pathological changes. The level and fluctuations of functional requirements to the circulation seem thus substantial for the development of the cardiotoxic effects.
Mikisková
H
H
Institute of Hygiene and Epidemiology, Centre of Industrial Medicine and Occupational Diseases, Praha.
Frantík
E
E
D000758:Anesthesia; D000818:Animals; D002248:Carbon Monoxide / Q000633:toxicity*; D002263:Carboxyhemoglobin / Q000032:analysis; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D008954:Models, Biological; D009043:Motor Activity / Q000187:drug effects; D005082:Physical Exertion / Q000187:drug effects; D051381:Rats / Q000502:physiology*
D002248:Carbon Monoxide; D002263:Carboxyhemoglobin