The regulation of expression of human beta-globin genes.
We have analyzed the regulation of expression of the human beta-globin gene by DNA mediated gene transfer in MEL cells and microinjection in fertilized mouse eggs. The results show that the beta-globin gene contains two regulatory elements: one element in the promoter, that is required for full transcriptional activity and, secondly, a tissue and developmental specific enhancer 3' to the gene.
Grosveld
F
F
Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, U.K.
Antoniou
M
M
van Assendelft
G B
GB
de Boer
E
E
Hurst
J
J
Kollias
G
G
MacFarlane
F
F
Wrighton
N
N
D000818:Animals; D001483:Base Sequence; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D005796:Genes; D005914:Globins / Q000235:genetics*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008845:Microinjections; D011401:Promoter Regions, Genetic; D013045:Species Specificity; D014162:Transfection
D005914:Globins