[Correspondence of mouse organs and tissues to the central and peripheral compartments of the kinetic model based on the drug-metabolite ratio in blood plasma and other tissues].
The kinetic scheme of distribution of a structural analogue of phenazepam 7-brom-5-phenyl-1,2-dihydro-3H-1,4-benzdiazepine-2-on (I) and its main metabolites in the mouse body was presented. The process parameters were compared with the parameters of mouse body distribution of other N1-unsubstituted derivatives of 1,4-benzdiazepine. It was shown that for the original preparation fatty tissue, liver, spleen, myocardium may be referred to the central compartment of the kinetic scheme of distribution. No organ or tissue functioning as the peripheral compartment of the kinetic scheme of the drug distribution was found. The gastrointestinal tract of the experimental animals can serve as the peripheral compartment of the kinetic scheme for products of biotransformation of I.
Zin'kovskiĭ
V G
VG
Golovenko
N Ia
NIa
Stankevich
E A
EA
Zhuk
O V
OV
Lisiutin
A V
AV
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000493:pharmacokinetics*; D001711:Biotransformation; D004064:Digestive System / Q000378:metabolism; D005260:Female; D008099:Liver / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D008954:Models, Biological; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C051604:7-bromo-5-phenyl-1,2-dihydro-2H-1,4-benzodiazepin-2-one
Sootvetstvie organov i tkaneĭ mysheĭ tsentral'nomu i perifericheskomotsekam kineticheskoĭ modeli, osnovannoe na dannykh sootnosheniia lekarstvo/metabolit v plazme krovi i drugikh tkaniakh.