Effects of antitussive drugs under normal and pathological conditions.
The antitussive effect codeine and 1-propoxyphene have been studied in non-anaesthetized healthy cats and cats with respiratory tract inflammation elicited by undiluted croton oil. The drugs were administered intraperitoneally in doses of 10 and 20 mg/kg body weight. The antitussive effect was studied on the 4th day, after inflammation had set in. Cough induced in nonanaesthetized cats by mechanical irritation of the laryngopharyngeal and tracheobronchial areas was evaluated by changes of the lateral tracheal pressure. Experimentally induced inflammatory changes of the respiratory tract due to the antitussive activity of 1-porpoxyphene were significantly reduced, but that of codeine had not changed at all.
Department of Pathophysiology and Pharmacology, Faculty of Medicine, Comenius University, Martin, Czechoslovakia.
A
A
Strapková
G
G
Nosálová
J
J
Korpás
D000818:Animals; D002415:Cats; D003061:Codeine / Q000627:therapeutic use*; D003371:Cough / Q000188:drug therapy*; D003436:Croton Oil; D011431:Dextropropoxyphene / Q000627:therapeutic use*; D005260:Female; D007249:Inflammation / Q000139:chemically induced; D008297:Male; D010812:Physical Stimulation; D012140:Respiratory Tract Diseases / Q000188:drug therapy*
D003436:Croton Oil; D011431:Dextropropoxyphene; D003061:Codeine