An experimental study of atherosclerosis as a sequela of coronary arteritis.
In order to examine the effect of corticosteroids on coronary atherogenesis in collagen diseases, an experimental study of serum sickness was performed. Forty-two rabbits were divided into four groups (Groups A-D). Group B, C and D rabbits received four intravenous injections of bovine serum albumin (250 mg/Kg) at 16-day intervals. Groups A, C and D rabbits were fed ad libitum cholesterol supplemented diet (1%) 16 days after the last injection. Group D rabbits received subdermal injections of prednisolone (1 mg/Kg) three times per week in the same period. After 124 days, all rabbits were sacrificed. Serum cholesterol and phospholipid increased in Group A, C and D rabbits. Group A rabbits showed intimal foam cell proliferation. Group B rabbits showed slight fibrous intimal thickening. The coronary arteries of Group C rabbits showed fatty-proliferative intimal thickening and an increase in the incidence of vascular lesions (13.9% of the coronary arteries as compared with 11.7% for Group A and 8.4% for Group B). The coronary lesions of Group D showed the same pattern as those of Group C, but the incidence of lesions was 6.0%. It was concluded that prednisolone did not augment immunologically induced atherosclerosis.
Department of Internal Medicine, School of Medicine, Juntendo University, Tokyo, Japan.
S
S
Kawai
R
R
Okada
Y
Y
Fukuda
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology*; D001167:Arteritis / Q000097:blood / Q000150:complications*; D002417:Cattle; D003327:Coronary Disease / Q000097:blood / Q000209:etiology*; D003331:Coronary Vessels / Q000473:pathology; D004195:Disease Models, Animal; D008297:Male; D011817:Rabbits; D012709:Serum Albumin / Q000008:administration & dosage; D012713:Serum Sickness / Q000097:blood / Q000150:complications*
D012709:Serum Albumin