Influence of N,N'-(1,11-undecandiyl) bis (2,3-dihydro-2-methyl-1H-indole-1-carboxamide) (BAY 02752) on gallstone formation and regression in hamsters.
A new hypolipidemic drug (BAY 02752) when added to a lithogenic hamster diet at dosages of 1000 and 500 mg per kg of diet significantly (p less than 0.005) inhibited gallstone formation. When BAY 02752 was fed to hamsters with pre-established gallstones, it inhibited progression (p=0.052) of the stones and appeared to promote dissolution.
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.
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Kritchevsky
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Klurfeld
D000818:Animals; D002769:Cholelithiasis / Q000188:drug therapy / Q000517:prevention & control*; D006224:Cricetinae; D004032:Diet; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008647:Mesocricetus
D000960:Hypolipidemic Agents; D007211:Indoles; C055192:Bay 02752