Effect of suspending agents on the characteristics of some anti-inflammatory suspensions.
The effect of suspending agents on the physical stability and in vitro availability of mefenamic acid, flufenamic acid, glafenine, ibuprofen and azapropazone suspensions was studied. The ulcerogenic effect of these formulated suspensions on the stomach of rats was also investigated. The results revealed that 2% veegum and 2% sorbitol gave the best formulated suspension for glafenine as compared to other formulations. On the other hand, 2% veegum, 2% sobitol and 1% avicel was found to improve the physical stability of mefenamic acid and flufenamic acid suspensions. Also, the combination of 1% veegum, 1% sorbitol and 1% algin produced excellent suspension for ibuprofen and azapropazone as compared to other combinations. The results of in vitro release data proved an optimal availability of the above mentioned formulations. In addition, significant reduction in the gastric erosions in stomach of rats was observed in all mentioned suspensions except glafenine suspension.
Department of Pharmaceutics, Faculty of Pharmacy, University of Mansoura, A.R.E.
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F
Hashem
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E
Ramadan
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Y
el-Said
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000032:analysis / Q000633:toxicity; D004355:Drug Stability; D004356:Drug Storage; D005079:Excipients; D005753:Gastric Mucosa / Q000033:anatomy & histology / Q000187:drug effects; D051381:Rats; D013535:Suspensions
D000893:Anti-Inflammatory Agents; D005079:Excipients; D013535:Suspensions