Plasma and tissue concentrations of ceforanide and cefazolin in women undergoing hysterectomy.
Thirty-four women who underwent vaginal hysterectomy received either ceforanide or cefazolin as perioperative antimicrobial prophylaxis. Samples of plasma, myometrium, endometrium and fallopian tubes were obtained at various intervals after injection and were assayed for cephalosporin concentration. Following intramuscular injection approximately 1 h prior to surgery, both drugs provided adequate tissue levels at the time of the procedure. Although both antimicrobials achieved similar tissue concentrations, all tissue samples for ceforanide exceeded the MIC90 for Escherichia coli while in the cefazolin group 9/18 myometrial samples and 10/15 endometrial samples fell below the MIC90 for this organism.
Department of Pharmacy, Brigham and Women's Hospital, Boston, Mass.
P F
PF
Souney
S
S
Fisher
R E
RE
Tuomala
B F
BF
Polk
C
C
Simpson
D000328:Adult; D002435:Cefamandole / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D002437:Cefazolin / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004717:Endometrium / Q000032:analysis; D005187:Fallopian Tubes / Q000032:analysis*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007045:Hysterectomy, Vaginal; D007273:Injections, Intramuscular; D008875:Middle Aged; D009215:Myometrium / Q000032:analysis; D011292:Premedication; D014018:Tissue Distribution; D014599:Uterus / Q000032:analysis*
D002435:Cefamandole; C012653:ceforanide; D002437:Cefazolin