Dose dependency of 99mTc disofenin (DISIDA) in biliary tract imaging.
Data presented on pharmacological effects of gadolinium labeled disofenin (DISIDA) upon administration of large mass amounts suitable to produce MR contrast prompted us to investigate these effects with technetium labeled DISIDA. A variable mass of [99mTc]Tc-DISIDA, 0.05-100 mg, was administered to rabbits. The effective half life in the liver did not vary significantly for doses between 0.05 and 5 mg, with an average of about 17 min. However, the effective half life increased to about 300 min for a 100 mg dose of DISIDA.
Najafi
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Division of Nuclear Medicine, University of Texas Medical Branch, Galveston 77550.
D000818:Animals; D001659:Biliary Tract / Q000000981:diagnostic imaging*; D006207:Half-Life; D007098:Imino Acids; D008099:Liver / Q000000981:diagnostic imaging; D009942:Organometallic Compounds; D011817:Rabbits; D011877:Radionuclide Imaging; D011933:Reagent Kits, Diagnostic; D013667:Technetium; D019785:Technetium Tc 99m Disofenin
D007098:Imino Acids; D009942:Organometallic Compounds; D011933:Reagent Kits, Diagnostic; D013667:Technetium; D019785:Technetium Tc 99m Disofenin