Studies on serum binding of some drugs.
Binding of three potential antidepressive compounds, EGYT-3615, EGYT-475 (trelibet) and EGYT-2760 to human serum was investigated by equilibrium dialysis method using radiolabelled drugs. All three compounds bound to serum proteins and the binding was sensitive to pH and salt concentration. The binding of trelibet and EGYT-3615 was not saturable at a wide range of drug concentration. The results show that EGYT-3615 has both specific and non-specific, while trelibet has only non-specific binding sites on serum proteins.
Department of Pharmacodynamics, Semmelweis University of Medicine, Budapest, Hungary.
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E
Szökö
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H
Kalász
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L
Kerecsen
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K
Magyar
D000928:Antidepressive Agents / Q000493:pharmacokinetics; D001798:Blood Proteins / Q000378:metabolism; D003956:Dialysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007546:Isoquinolines / Q000502:physiology; D004364:Pharmaceutical Preparations / Q000097:blood*; D010879:Piperazines / Q000493:pharmacokinetics; D011485:Protein Binding; D012965:Sodium Chloride / Q000494:pharmacology
D000928:Antidepressive Agents; D001798:Blood Proteins; D007546:Isoquinolines; D004364:Pharmaceutical Preparations; D010879:Piperazines; C054715:EGYT 3615; C040401:EGYT 475; C006737:1-benzylpiperazine; D012965:Sodium Chloride