Fructosamine concentrations in general population of Kawerau.
We measured fructosamine concentrations in nonfasted serum from 7094 residents (82.8% of the estimated population) of Kawerau, New Zealand, including 65 known diabetic patients (prevalence of 0.92%). Fructosamine results showed a trimodal frequency distribution, with cutting points corresponding to 5th and 95th percentile values. Forty-two diabetic individuals had levels that exceeded the 95th percentile. These individuals had more severe metabolic abnormalities, characterized by lower plasma C-peptide and elevated fasting plasma glucose concentrations. Mean fructosamine values also showed a significant increase with age and a highly significant age-ethnic interaction that paralleled the higher frequency of diabetes in older age groups and among elderly Maori people. However, as a screening method in the general population, fructosamine measurement was diagnostically deficient because of a weak correlation with serum albumin. Arithmetic correction for albumin concentration in the sample did not increase the diagnostic usefulness of the test.
Baker
J
J
Department of Clinical Biochemistry, Green Lane Hospital, Auckland, New Zealand.
Metcalf
P
P
Scragg
R
R
D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000032:analysis; D003920:Diabetes Mellitus / Q000097:blood; D005006:Ethnicity; D005060:Europe / Q000208:ethnology; D005260:Female; D019270:Fructosamine; D006595:Hexosamines / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009520:New Zealand; D012709:Serum Albumin / Q000032:analysis; D044465:White People
D001786:Blood Glucose; D002096:C-Peptide; D006595:Hexosamines; D012709:Serum Albumin; D019270:Fructosamine