House dust extracts contain potent immunological adjuvants.
A crude aqueous extract of house dust and two house dust subfractions were tested for adjuvant activity in a sensitivity assay performed in mice. Evidence is presented that house dust contains at least two potent immunological adjuvants. One of these, present in both subfractions, was probably endotoxin and acted in a complement-independent way. The immunostimulatory effect of the other adjuvant was abrogated by prior complement depletion of the animals. This apparently complement-dependent adjuvant needs further identification.
Immunology Section of the Laboratory of Microbiology, State University, Utrecht, The Netherlands.
C J
CJ
Beukelman
H
H
van Dijk
P C
PC
Aerts
P M
PM
Rademaker
L
L
Berrens
J M
JM
Willers
D000276:Adjuvants, Immunologic; D000818:Animals; D004391:Dust; D004912:Erythrocytes / Q000276:immunology; D006386:Hemagglutination Tests; D007114:Immunization; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D051379:Mice
D000276:Adjuvants, Immunologic; D004391:Dust; D007075:Immunoglobulin M