Absorption of bendazac lysine after topical application to the rabbit eye.
A water solution of 0.5% 14C-3-bendazac lysine was administered to the rabbit eye. Following single application to the cornea, the drug was found in different ocular compartments including the lens. Although in the lens the concentrations are lower as compared to the iris, retina ciliary bodies and aqueous humor, they last longer.
Valeri
P
P
Institute of Pharmacology and Pharmacognosy, University of Rome, La Sapienza.
Palmery
M
M
Martinelli
B
B
Catanese
B
B
D000042:Absorption; D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005123:Eye / Q000378:metabolism*; D007191:Indazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D011720:Pyrazoles / Q000493:pharmacokinetics*; D011817:Rabbits
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007191:Indazoles; D011720:Pyrazoles; C036067:bendazac lysine