[A combination of dihydroergotamine and acetylsalicylic acid--prevention of postoperative thromboembolic complications. Clinical study in orthopedics].
202 patients undergoing surgery involving the lower limbs were given antithrombotic treatment for at least 21 days, or until they had regained full mobility. Following subcutaneous prophylaxis with a combination of heparin and dihydroergotamine, two oral regimens were compared in a controlled and randomized prospective study. The first treatment consisted of a combination of acetylsalicylic acid (ASA) and dihydroergotamine (DHE), and the second of acenocoumarol. The radiofibrinogen uptake test was carried out in high-risk patients (i.e. those undergoing hip surgery) to detect deep-vein thrombosis. No statistically significant difference was found between the two groups. However, the ASA/DHE combination enjoyed better patient acceptance and was much easier to use.
Département de chirurgie, Hôpital cantonal universitaire, Genève.
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D000074:Acenocoumarol / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001241:Aspirin / Q000008:administration & dosage*; D004087:Dihydroergotamine / Q000008:administration & dosage*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007866:Leg / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D011897:Random Allocation; D013923:Thromboembolism / Q000517:prevention & control*
D004087:Dihydroergotamine; D000074:Acenocoumarol; D001241:Aspirin
Association de dihydroergotamine et d'acide acétylsalicylique--prophylaxie des complications thromboemboliques postopératoires. Etude clinique en orthopédie.