Hepatotoxicity of ethanol in mice.
Mice continuously exposed to ethanol vapour (for up to 19 days) developed fatty change in the liver (from 2 days onwards) and lesions resembling those of alcoholic hepatitis in man (from 5 days onwards). They also showed biochemical evidence of liver cell damage. Sera from ethanol-treated animals contained immunoglobulins that bound to the hepatocytes of ethanol-treated but not of control animals suggesting that exposure to ethanol was followed by an immunological response to a hepatocyte neo-antigen. In addition, such sera were cytotoxic in an in-vitro assay, and on Sephacryl S-300 gel filtration the cytotoxic activity eluted together with albumin molecules.
Department of Experimental Pathology, St Mary's Hospital Medical School, University of London, UK.
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Goldin
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Wickramasinghe
D000280:Administration, Inhalation; D000818:Animals; D002850:Chromatography, Gel; D003602:Cytotoxicity, Immunologic; D000431:Ethanol / Q000633:toxicity*; D005235:Fatty Liver, Alcoholic / Q000209:etiology; D005260:Female; D006519:Hepatitis, Alcoholic / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL
D000431:Ethanol