[Thrombolysis of cerebral thromboembolism by urokinase in an animal model].
The majority of ischemic cerebral insults are caused by thromboembolism. In animal experiments we have investigated the possibility of reperfusing ischemically damaged brain tissue by thrombolysis of cerebral emboli. 1, 3 and 5 hours after cerebral infarction due to thromboembolism, thrombolytic treatment with urokinase (1000 IU/kg/min) was started. Thrombolysis, monitored by angiography, was successful in all cases (n = 15). In all cases the fall in fibrinogen, alpha 2-antiplasmin and plasminogen reflected systemic fibrinolytic effects. Anatomo-pathologic investigation of the brains revealed no intracerebral bleeding complications. The results of the study suggest a favourable effect of urokinase on acute ischemic cerebral infarction.
Hirschberg
M
M
Klinik für Neurologie und Radiologie, Universität Münster.
Korves
M
M
Koc
I
I
Hofferberth
B
B
Wiesmann
W
W
D000208:Acute Disease; D000818:Animals; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000209:etiology; D004285:Dogs; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D002542:Intracranial Embolism and Thrombosis / Q000150:complications / Q000188:drug therapy*; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage
D005343:Fibrinolytic Agents; D014568:Urokinase-Type Plasminogen Activator
Untersuchungen zur Thrombolyse zerebraler Thrombembolien mittels Urokinase an einem Tiermodell.