[Value of microhematuria, urine cytology, TPA and neopterin in the after care of patients with bladder tumors].
Tumor recurrences were observed 70 times in 715 cystoscopies performed in 253 patients. The sensitivity of microhematuria to detect a tumor recurrence was 61%, the specificity 84%. The sensitivity of microhematuria increased to 90% in Tis and T2 tumors. Urine cytology showed a specificity of 100% and a sensitivity of only 43%. The specificity and sensitivity of TPA was only 58% and 41%, respectively, the latter increased to 80% in Tis. 60 patients with proven tumor recurrence showed an increase of neopterin with higher tumor stage. In tumors of stage T2 and Tis serum neopterin was raised in 90% and urine neopterin in 75%. Based on these results cystoscopy, exfoliative urinary cytology and urine analysis are obligatory in the follow-up of patients with superficial bladder cancer. Because of the low specificity (29-41%) TPA and neopterin are not suitable for follow-up.
Mack
D
D
Universitätsklinik für Urologie, Innsbruck, Osterreich.
Scheiber
K
K
Rauschmeier
H
H
Hamberger
L
L
Jakse
G
G
D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D003558:Cystoscopy; D006417:Hematuria / Q000473:pathology*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D019798:Neopterin; D010455:Peptides / Q000097:blood*; D019396:Tissue Polypeptide Antigen; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000473:pathology*; D014556:Urine / Q000166:cytology*
D010455:Peptides; D019396:Tissue Polypeptide Antigen; D001708:Biopterins; D019798:Neopterin
Der Wert Mikrohämaturie, Harnzytologie, TPA und Neopterin in der Nachsorge von Blasentumorpatienten.