The effect of antihypertensive treatment on the circulating hypertensive factor in the spontaneously hypertensive rat.
To elucidate the role of circulating hypertensive factors in the spontaneously hypertensive rat and the effects of antihypertensive treatment on the circulating hypertensive factor, cross circulation was performed in 54 couples of spontaneously hypertensive and normotensive rats. In normotensive rats cross-circulated with untreated spontaneously hypertensive rats mean arterial pressure increased by 20.9 +/- 12.2 mm Hg (p less than 0.01). Increases in mean arterial pressure were also obtained by cross-circulation with spontaneously hypertensive rats pretreated with propranolol, furosemide, and nifedipine. Mean arterial pressure was not changed by cross circulation after pretreatment of the spontaneously hypertensive rats with alpha methyldopa. It is concluded that in this strain of spontaneously hypertensive rats a circulating hypertensive factor exists, the secretion of which can be suppressed by the centrally acting drug, alpha methyldopa. Therefore either the central nervous system may take part in the regulation of the factor or the factor may be synthetized in the central nervous system.
Zidek
W
W
Med. Univ.-Poliklinik, Münster, F.R. Germany.
Ottens
E
E
Heckmann
U
U
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D003427:Cross Circulation; D005665:Furosemide / Q000494:pharmacology; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008750:Methyldopa / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR
D000959:Antihypertensive Agents; D008750:Methyldopa; D005665:Furosemide; D011433:Propranolol; D009543:Nifedipine