Use of experimental models to study the development of renal function.
By use of animal experiments it has been demonstrated that renal cells are immature at birth. Membrane transport is quantitatively and qualitatively different. The control of fluid and electrolyte balance is therefore different in infancy. The increased filtered load at birth as well as hormones will induce tubule maturation. The use of animal experiments will in the future give an insight into how external factors influence growth and maturation.
Department of Pediatrics, St. Göran's Children's Hospital, Stockholm, Sweden.
Y
Y
Fukuda
S
S
Larsson
G
G
Celsi
C
C
Lechene
A
A
Aperia
D000818:Animals; D001693:Biological Transport, Active; D002463:Cell Membrane Permeability; D005544:Forecasting; D007668:Kidney / Q000196:embryology / Q000254:growth & development* / Q000502:physiology; D007684:Kidney Tubules / Q000502:physiology; D008954:Models, Biological; D051381:Rats; D012964:Sodium / Q000378:metabolism
D012964:Sodium