The hypertensinogenic activity of 18-hydroxy-19-norcorticosterone in the adrenalectomized rat.
Hypertensinogenic properties of recently synthesized 18-OH-19-nor-B and the related 18-OH-B were examined in adrenalectomized, spontaneously hypertensive rats (SHR). Each steroid was given via Alzet miniosmotic pump (2002), with and without aldosterone. Neither 18-OH-19-nor-B (5 micrograms) nor 18-OH-B (5 micrograms) increased blood pressure in SHR when given alone, but when administered together with aldosterone (5 micrograms), which was ineffective by itself, resulted in a significant rise in blood pressure. There is a high probability that certain mineralocorticoids, which are inactive by themselves, are of importance in the etiology of hypertension under physiological conditions.
Hypertension Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel.
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T
Rosenthal
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M
Shani
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E
Peleg
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M
Harnik
D015069:18-Hydroxycorticosterone / Q000031:analogs & derivatives* / Q000502:physiology; D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D003345:Corticosterone / Q000031:analogs & derivatives*; D004353:Drug Evaluation, Preclinical; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR
C051358:18-hydroxy-19-norcorticosterone; D015069:18-Hydroxycorticosterone; D003345:Corticosterone