Effects of in vitro generated oxygen free radicals on transmembrane potentials in ventricular cardiac muscle.
The effects of in vitro generated oxygen free radicals on transmembrane potentials in guinea pig papillary muscles were investigated. Superfusion of the muscle with the oxygen free radical generating medium (1 mM xanthine + 10 U/l xanthine oxidase) for 40 min altered significantly neither the resting nor the action potentials characteristics. We propose that electrophysiological changes leading to the reperfusion-induced arrhythmias may be secondary to an inhomogenous change in the coronary myocardial perfusion produced by the radicals.
Department of Clinical Physiology, Medical Centre of Postgraduate Education, Warsaw, Poland.
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A
Beresewicz
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E
Karwatowska-Kryńska
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L
Firek
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology; D003327:Coronary Disease / Q000150:complications / Q000378:metabolism; D005260:Female; D005609:Free Radicals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials; D010100:Oxygen / Q000378:metabolism*; D010210:Papillary Muscles / Q000378:metabolism*; D019820:Xanthine; D014969:Xanthine Oxidase / Q000378:metabolism; D014970:Xanthines / Q000378:metabolism
D005609:Free Radicals; D014970:Xanthines; D019820:Xanthine; D014969:Xanthine Oxidase; D010100:Oxygen