Effect of multiple doses of clonazepam on the nitroreductase activity in hepatic microsomal preparation from rat.
The hepatic microsomal nitroreductase activity and urinary excretion of the sum of the main metabolites of clonazepam (CNZ) were investigated in rats that had received 7 daily injections of 2 mg/kg of the compound. Despite the significant decrease in CNZ nitroreductase activity, there was only poor correlation between the enzyme activity and excretion of the assayed metabolites.
Medical Academy, Department of Pharmacology, Poznań, Poland.
D
D
Cenajek-Musiaø
K
K
Szczawińska
E
E
Nowakowska
D000818:Animals; D001711:Biotransformation; D002998:Clonazepam / Q000494:pharmacology* / Q000652:urine; D004361:Drug Tolerance; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009601:Nitroreductases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D002998:Clonazepam; D010088:Oxidoreductases; D009601:Nitroreductases