Intra-articular bupivacaine for pain relief after arthroscopic surgery of the knee joint in daycase patients.
A randomised double-blind study was conducted to compare the influence on postoperative pain of equal volumes of one of two concentrations of bupivacaine (0.25%, 0.5%), or saline 0.9%, injected into the knee joint after arthroscopy. The results showed that intra-articular bupivacaine had no significant analgesic effect in either concentration. Plasma bupivacaine concentrations were measured 20 minutes after injection in order to determine the extent of systemic absorption.
Milligan
K A
KA
Mansfield and District General Hospital, Nottinghamshire.
Mowbray
M J
MJ
Mulrooney
L
L
Standen
P J
PJ
D000293:Adolescent; D000328:Adult; D000556:Ambulatory Surgical Procedures; D000772:Anesthesia, Local; D001182:Arthroscopy; D002045:Bupivacaine / Q000008:administration & dosage / Q000097:blood; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000628:therapy*
D002045:Bupivacaine