The ontogeny of the antidipsogenic effect of eledoisin and physalaemin in the rat.
The ontogeny of the antidipsogenic effect of the tachykinins eledoisin and physalaemin was studied in 1- to 12-day-old Wistar rats. Both peptides inhibited drinking evoked by ICV angiotensin II, cell-dehydration or fluid deprivation. The effect of eledoisin appeared earlier than that of physalaemin (third v. sixth day) and was evoked by lower doses (10-100 ng/rat vs 330-1000 ng rat). The two tachykinins also inhibited milk intake, but this effect occurred only in the earliest days of neonatal life. The results confirm the specificity of the antitipsogenic effect of eledoisin and physalaemin and give further support to the hypothesis that brain tachykinins play a physiological role in the control of fluid intake.
Institute of Pharmacology, University of Camerino, Italy.
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G
De Caro
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Perfumi
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Epstein
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D003681:Dehydration; D004326:Drinking / Q000187:drug effects; D004600:Eledoisin / Q000494:pharmacology*; D007705:Kinins / Q000494:pharmacology*; D008892:Milk; D010803:Physalaemin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013894:Thirst / Q000187:drug effects*; D014868:Water Deprivation
D007705:Kinins; D000804:Angiotensin II; D010803:Physalaemin; D004600:Eledoisin