Evaluation of Artemisia inculta for anti-inflammatory activity in rats.
The ethanolic extract of Artemisia inculta has been screened for anti-inflammatory, analgesic and antipyretic activities on suitable experimental models. It has been found to produce significant inhibition of carrageenan induced paw edema and cotton pellet induced granuloma pouch and a significant decrease in the prothrombin time in rats. It failed to produce any analgesic or antipyretic activity on the hot plate reaction time and yeast induced hypyrexia tests in mice. It also did not produce any effect on the platelet aggregation and fibrinogen level in the rats. Amongst the phytoconstituents detected in this plant, flavonoids may be responsible for the observed anti-inflammatory effect of the ethanolic extract.
Tariq
M
M
Research Centre, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Mossa
J S
JS
Al-Yahya
M A
MA
Parmar
N S
NS
Ageel
A M
AM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004487:Edema / Q000188:drug therapy; D005334:Fever / Q000188:drug therapy; D006099:Granuloma / Q000188:drug therapy; D008516:Medicine, Chinese Traditional; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts