A model for quantitative evaluation of embolic stroke therapy.
We developed a small animal embolic stroke model for pharmacological screening trials. Microspheres are injected into the carotid circulations and group embolus dose-response relationships are calculated. Emboli quantity is related to neurologic injury, and small changes in neurologic function are detectable. Rabbits tolerated twice as many microspheres when cyproheptadine-treated after embolization. This demonstrated both the sensitivity of the model and the value of serotonin antagonists in reducing neurological injury.
Zivin
J A
JA
Neurology Service, Veterans Administration Medical Center, San Diego, CA.
DeGirolami
U
U
Kochhar
A
A
Lyden
P D
PD
Mazzarella
V
V
Hemenway
C C
CC
Henry
M E
ME
D000818:Animals; D001160:Arterioles / Q000473:pathology; D002540:Cerebral Cortex / Q000098:blood supply / Q000473:pathology; D003533:Cyproheptadine / Q000627:therapeutic use*; D004195:Disease Models, Animal; D002542:Intracranial Embolism and Thrombosis / Q000188:drug therapy*; D008297:Male; D008863:Microspheres; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D003533:Cyproheptadine