[Hepatic and renal changes in albino rats caused by the administration of chromium (VI) in drinking water].
The effects of sodium chromate administered in drinking water on liver and kidney of albino rats have been studied, through investigation of histological alterations and monitoring changes on serum urea levels and transaminases (GOT and GPT). Measurements have been done after 4, 8 and 12 weeks of treatment. The liquid intake of treated animals decreases with time. The amount of water drunk by treated rats is 1/2 of that drink by controls after 12 weeks. The histological alterations in liver and kidney are similar to those described elsewhere. Serum urea level is always higher in treated animals than in controls. GOT levels are similar in both treated and control rats, although always higher in the treated ones. GPT levels increase significantly after 12 weeks of treatment.
Departamento de Fisiología Animal, Facultad de Ciencias Biológicas, Valencia, España.
R
R
Laborda
J
J
Díaz-Mayans
A
A
Núñez
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D002857:Chromium / Q000633:toxicity*; D004326:Drinking / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014508:Urea / Q000097:blood
D002857:Chromium; D014508:Urea
Alteraciones hepáticas y renales en rata albina por administración de cromo (VI) en agua de bebida.