The granulomatous inflammatory response in jirds, Meriones unguiculatus, to Brugia pahangi: an ultrastructural and histochemical comparison of the reaction in the lymphatics and peritoneal cavity.
A granulomatous inflammatory response develops in jirds with lymphatic or intraperitoneal infections of Brugia pahangi. Light, histochemical, and ultrastructural microscopy were used for comparative studies of the reactions in these 2 locations. The reactions observed were categorized into 3 types: (1) an initial response in which lymphocytes, monocytes, macrophages, and eosinophils were present; (2) an intermediate one which consisted of macrophages, epithelioid cells, lymphocytes, eosinophils, collagen, and mesothelial/endothelial cells with central areas of necrosis; and (3) a terminal reaction consisting of degenerating, necrotic cells. Microfilariae and adult worms were associated with these reactions. Macrophages were the predominant cell type in the lesion and were often found attached to the surface of the parasite. The inflammatory responses to B. pahangi in the lymphatics and in the peritoneal cavity appear to be similar, and thus, the peritoneal cavity may be useful in studying specific cell-parasite interactions to further define the pathogenesis of filarial disease.
Jeffers
G W
GW
Department of Veterinary Microbiology and Parasitology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803.
Klei
T R
TR
Enright
F M
FM
Henk
W G
WG
D000818:Animals; D002009:Brugia; D004195:Disease Models, Animal; D004605:Elephantiasis, Filarial / Q000473:pathology*; D005260:Female; D005368:Filariasis / Q000473:pathology*; D005849:Gerbillinae; D006099:Granuloma / Q000473:pathology; D006651:Histocytochemistry; D008205:Lymphangitis / Q000473:pathology*; D008208:Lymphatic System / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D010529:Peritoneal Cavity / Q000473:pathology / Q000648:ultrastructure*; D010538:Peritonitis / Q000473:pathology*