The action of cisapride on the chronic constipation of paraplegia.
Paraplegic patients have intractable constipation associated with prolonged colonic transit time. The agent Cisapride significantly reduced the colonic transit time from 7.7 days to 5.1 days. It also improved the intraluminal tone in the rectum, resulting in a significant reduction in maximal rectal capacity from 305.8 ml to 224.3 ml. There was a reduction in residual urine volume from 51.5 ml to 27.7 ml. The increased number of stools containing transit markers showed that intraluminal mixing was increased by cisapride. Faecal water remained unchanged. A side effect was retention of urine in one subject after sudden withdrawal of the drug but this was avoided by its gradual reduction over 2 days.
Spinal Injuries Unit, Edenhall Hospital, Musselburgh, UK.
N R
NR
Binnie
G H
GH
Creasey
P
P
Edmond
A N
AN
Smith
D000284:Administration, Oral; D000328:Adult; D001003:Anal Canal / Q000503:physiopathology; D002908:Chronic Disease; D020117:Cisapride; D003248:Constipation / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000150:complications* / Q000503:physiopathology; D010880:Piperidines / Q000008:administration & dosage / Q000627:therapeutic use*; D012007:Rectum / Q000503:physiopathology; D014554:Urination / Q000187:drug effects
D010880:Piperidines; D020117:Cisapride