Bioavailability and pharmacokinetics of a new controlled-release theophylline preparation in the form of capsules containing pellets.
The bioavailability and pharmacokinetics of a new controlled-release theophylline preparation in the form of capsules containing pellets of coated drug were studied in 10 healthy subjects. Results showed that the bioavailability of this preparation is complete after oral intake of a single dose, while after repeated administrations (300 mg b.i.d.) theophylline serum levels are constantly within the therapeutic range (10-15 mg/l) with small fluctuations over 12 h. Side effects were not observed.
Istituto di Clinica Tisiologica e Malattie dell'Apparato Respiratorio, Università di Genova, Ospedale Maragliano, Italia.
S
S
Valenti
P
P
Crimi
V
V
Brusasco
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D013806:Theophylline / Q000008:administration & dosage / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D013806:Theophylline