The metabolic origin of the sulfur atom in the sulfhydryl group of 2-thiobenzothiazole metabolites derived from benzothiazyl sulfenamide in the rat.
After administration of benzothiazyl sulfenamide to rats, over 90% of the S atom in the sulfhydryl group was retained in 2-thiobenzothiazole metabolites. The S atom in 2-benzothiazyl mercapturic acid, a major metabolite, was mostly replaced by the endogenous S from the L-cysteine pool.
Division of Biological Chemistry, National Institute of Hygienic Sciences, Tokyo, Japan.
M
M
Fukuoka
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A
Tanaka
D000284:Administration, Oral; D000818:Animals; D052160:Benzothiazoles; D005243:Feces / Q000032:analysis; D008099:Liver / Q000032:analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000032:analysis*; D013455:Sulfur / Q000032:analysis*; D013844:Thiazoles / Q000032:analysis* / Q000378:metabolism*
D052160:Benzothiazoles; D013438:Sulfhydryl Compounds; D013844:Thiazoles; C055087:2-benzothiazylsulfenamide; C005563:captax; D013455:Sulfur