Antihypertensive effects of mesulergine: further evidence for a peripheral site of action of dopamine agonists.
The cardiovascular effects of mesulergine were studied in anesthetized dogs. Intravenous (IV) administration (0.3 mg/kg) significantly decreased blood pressure in neurogenic hypertensive dogs without any change in heart rate. This effect was completely antagonized by IV administration of domperidone (0.5 mg/kg). Intracisternal administration of mesulergine (0.03, 0.3 and 3 mg/kg) did not produce any change in blood pressure. However, with the highest dose we observed a significant rise in heart rate during the first 2 min (which was probably nonspecific). These results suggest that mesulergine lowers blood pressure in sinoaortic-denervated dogs by means of a peripheral mechanism probably involving DA2 receptors. The findings confirm the potential interest of dopamine-receptor agonists as future antihypertensive agents.
Laboratoire de Pharmacologie, Université de Bordeaux II, France.
B
B
Begaud
L
L
Dang Tran
J L
JL
Montastruc
P
P
Montastruc
D000818:Animals; D000959:Antihypertensive Agents; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002946:Cisterna Magna; D004285:Dogs; D004873:Ergolines / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007267:Injections; D007275:Injections, Intravenous; D008297:Male; D011954:Receptors, Dopamine / Q000187:drug effects*
D000959:Antihypertensive Agents; D000978:Antiparkinson Agents; D004873:Ergolines; D011954:Receptors, Dopamine; C031649:mesulergine