Altered chromatin structure associated with a partial trisomy of chromosome 7 in the mouse.
The chromatin of a mouse that is trisomic for part of chromosome 7 was investigated. Chromatin from trisomic tissue has a smaller average nucleosome DNA repeat length than chromatin from tissue taken from normal diploid littermates. DNA of the nucleosome cores is the same size in both normal and trisomic tissues. Not all of the nucleosome monomers have different repeat lengths. Normal and trisomic mouse kidney cells in tissue culture maintained their nucleosome repeat-length differences.
Rake
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AV
Biological Sciences, Wright State University, Dayton, Ohio 45435.
Edwards
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RH
D000818:Animals; D002843:Chromatin; D046508:Culture Techniques; D004587:Electrophoresis, Agar Gel; D005260:Female; D007668:Kidney / Q000032:analysis; D008297:Male; D051379:Mice; D009707:Nucleosomes / Q000032:analysis; D014314:Trisomy
D002843:Chromatin; D009707:Nucleosomes