Endothelial cell modulation of primary platelet hemostasis.
Rheology has profound effects on the rate, structure, and modulation of primary hemostasis. Many of these effects can be studied via real-time, epifluorescence videomicroscopy of platelet adhesion-aggregation to a site of injury to an endothelial cell monolayer exposed to flowing blood. In particular, with the model described, endothelial cells can be shown to be a significant modulator of platelet function at an injury site.
Grabowski
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Division of Pediatric Hematology/Oncology, New York Hospital-Cornell Medical Center, New York 10021.
D001792:Blood Platelets / Q000502:physiology; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000473:pathology*; D006487:Hemostasis; D006801:Humans; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D012212:Rheology