Improved penetration of spermatozoa into uterine fluids of women with abnormal postcoital tests.
Cervical mucus-uterine fluid cross-penetration of husbands' and control sperm was assessed in 13 couples with poor or negative postcoital tests. Cervical mucus scoring and tray agglutination test identified six women with sperm-agglutinating antibodies and seven women with cervical dysmucorrhea. All males were normozoospermic, with penetration into control cervical mucus and control uterine fluids. Control sperm penetrated into cervical mucus and uterine fluids of three and five of the women with sperm-agglutinating antibodies and cervical dysmucorrhea, respectively. Penetration of husbands' spermatozoa into uterine fluids of patients with sperm-agglutinating antibodies was lower than that of control semen (P less than .05). Control and husbands' sperm penetration into uterine fluids of women with cervical dysmucorrhea were identical. In both groups, husbands' and control sperm penetrated uterine fluids more frequently than cervical mucus (75 versus 12%; P less than .001). On a six-month follow-up and midcycle intrauterine inseminations, six patients (46%) conceived. We conclude that uterine fluids of patients with sperm-agglutinating antibodies and cervical dysmucorrhea may provide a better milieu for spermatozoa than cervical mucus. This observation suggests a rationale for intrauterine inseminations to achieve pregnancy.
Confino
E
E
Department of Obstetrics and Gynecology, Mount Sinai Hospital Medical Center, Chicago, Illinois.
Friberg
J
J
Gleicher
N
N
D000906:Antibodies / Q000276:immunology; D001826:Body Fluids / Q000502:physiology*; D002582:Cervix Mucus; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis*; D008297:Male; D013073:Sperm Agglutination; D013084:Sperm-Ovum Interactions; D013094:Spermatozoa / Q000276:immunology; D014599:Uterus / Q000378:metabolism
D000906:Antibodies