Determination of terbutaline sulfate in dosage forms by liquid chromatography with electrochemical detection.
A liquid chromatographic method with electrochemical detection has been developed for the determination of terbutaline sulfate in dosage forms. A cyanopropyl bonded-phase column is used with a mobile phase consisting of methanol-0.1 M monobasic potassium phosphate containing 0.1M sodium heptanesulfonate and 1mM disodium ethylenediaminetetraacetate (15 + 85). The compound of interest is detected at a glassy carbon electrode held at a potential of +0.9 V vs silver-silver chloride. The response is linear from 0 to 10 micrograms/mL terbutaline sulfate. The method is applicable to tablet composites, individual tablets, dissolution determinations, and injections. Results and supporting data are reported for the above analyses.
Childress
W L
WL
Food and Drug Administration, Boston, MA 02109.
D002853:Chromatography, Liquid; D004563:Electrochemistry; D013607:Tablets; D013726:Terbutaline / Q000032:analysis*
D013607:Tablets; D013726:Terbutaline