Dense metaphyseal bands and growth arrest associated with isotretinoin therapy.
A 9-year-old boy, treated with high-dose isotretinoin therapy for fibrodysplasia ossificans progressiva, developed dense metaphyseal bands and growth arrest. Discontinuance of isotretinoin therapy was followed by gradual decrease of metaphyseal bands and resumption of clinical growth. The dense metaphyseal bands may be related to the known action of retinoids as modulators of chondrocyte phenotype and gene expression.
Human Genetics Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892.
J C
JC
Marini
S
S
Hill
M A
MA
Zasloff
D000293:Adolescent; D001835:Body Weight; D001846:Bone Development / Q000187:drug effects*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002648:Child; D006128:Growth / Q000187:drug effects*; D006801:Humans; D015474:Isotretinoin; D008297:Male; D009221:Myositis Ossificans / Q000150:complications / Q000188:drug therapy*; D011859:Radiography; D014103:Torticollis / Q000209:etiology; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use
D014212:Tretinoin; D015474:Isotretinoin