The influence of phenobarbital on the pharmacokinetics of propranolol in pregnancy.
In 7 pregnant hypertensive patients the elimination half-life of propranolol was enhanced to 6.1 +/- 1.2 h in comparison to 4.4 +/- 0.4 in 9 nonpregnant females. In 8 out of 11 pregnant hypertensive patients in the 29th week of gestation treated with 90 mg phenobarbital daily for at least 7 days before starting propranolol therapy, the half-life of propranolol was 3.1 +/- 0.4 h only. This significant difference between pregnant women with and without phenobarbital pretreatment is discussed as enzyme induction by phenobarbital.
Department of Clinical Pharmacology, Friedrich Schiller University, Jena, GDR.
A
A
Hoffmann-Traeger
G
G
Peiker
R
R
Glöckner
I
I
Wittmann
A
A
Balogh
L
L
Henschel
D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D010634:Phenobarbital / Q000494:pharmacology* / Q000627:therapeutic use; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood* / Q000188:drug therapy; D011433:Propranolol / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
D011433:Propranolol; D010634:Phenobarbital