[Characteristics of the effect of exometabolites of the cysticerci of the cat tapeworm Hydatigera taeniaeformis on fibroblasts in organ cultures].
The influence of the cestode H. taeniaeformis cysticercus exometabolites on the fibroblasts of their capsule in organ culture was studied. Half of explants were cultured in the presence of cestodes (the ratio between the parasite body weight and the cultural medium volume being 1:10 g/ml). After 2-30 days of cultivation the explants were examined by histological, histoautoradiographic and electron microscopic methods. The influence of cysticercus exometabolites on the culture resembled that of the growth-stimulating factors. The young, actively proliferating fibroblasts were mainly observed in the explants of the capsules cultured in the presence of cysticerci. Among the mature cells, fibroblasts with the predominance of the fibroclastic function were noticed rather than with the function of collagen biosynthesis. It is suggested that the change in the differentiation ways of fibroblasts may be due to some biologically active substrates of the cysticercus to be directed on slowing down the maturation of the connective tissue capsule.
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Adoeva
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002589:Cestoda / Q000166:cytology / Q000378:metabolism*; D003238:Connective Tissue / Q000187:drug effects / Q000378:metabolism; D003239:Connective Tissue Cells; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006790:Host-Parasite Interactions; D007814:Larva / Q000166:cytology / Q000378:metabolism; D008099:Liver / Q000469:parasitology; D009924:Organ Culture Techniques; D013268:Stimulation, Chemical; D013997:Time Factors
Osobennosti vliianiia ékzometabolitov tsistitserkov koshach'ego tsepnia Hydatigera taeniaeformis na fibroblasty v organnykh kul'turakh.