The pharmacokinetics of ketoconazole after chronic administration in adults.
We have studied the pharmacokinetics of the anti-mycotic ketoconazole in seven patients who took it for 1-6 months at a dose of 200 mg daily. The mean elimination half-life of the drug was 3.3 h, and although the ketoconazole was given only once daily, a satisfactory clinical response was obtained in all seven individuals. Only a small fraction of the absorbed drug (mean 0.22%) was excreted unchanged in the urine, suggesting almost complete metabolism. Our results support the concept that anti-mycotic activity in the tissues continues after the plasma drug concentration has fallen below a critical level. Our results also support the concept of a change in pharmacokinetics with chronic dosing.
Department of Chemical Pathology, Adelaide Children's Hospital, Australia.
N R
NR
Badcock
F D
FD
Bartholomeusz
D B
DB
Frewin
L N
LN
Sansom
J G
JG
Reid
D000328:Adult; D000368:Aged; D004334:Drug Administration Schedule; D005260:Female; D006207:Half-Life; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged
D007654:Ketoconazole