[Thyroid-stimulating autoantibodies in the blood of patients with diffuse toxic goiter].
The level of thyrostimulating autoantibodies (TSA) in IgG fraction isolated from the blood serum by precipitation of (NH4)2SO4 was determined in 36 patients with diffuse toxic goiter (DTG) and in 8 healthy donors. TCA which were assessed by a rise of the level of cAMP in human thyroid sections (obtained at operation from extranodal tissue of patients with nodal euthyroid goiter) after 2 h-incubation at 37 degrees C with IgG, were determined in 32 DTG patients (89%). The patients were divided into 2 groups with respect to their clinical and thyroid status: with a high and normal or subnormal content of the blood thyroid hormones. In the 1st group the frequency of detection (96%) and the level of TSA (570.64 +/- 109.63%) were much higher than in the 2nd group of patients (70 and 186.29 +/- 23.06%, respectively). The highest levels of TSA (1085.25 +/- 551.27%) were found in 4 of 26 patients (the 1st group) who had not received specific therapy.
Mkrtumova
N A
NA
Aleksandrova
G F
GF
Baslerova
Iu A
IuA
Bogdanov
V I
VI
Bobrovskaia
T A
TA
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis* / Q000502:physiology; D001327:Autoimmune Diseases / Q000209:etiology*; D005260:Female; D006111:Graves Disease / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism
D001323:Autoantibodies; D007074:Immunoglobulin G; D013963:Thyroid Hormones
Tireostimuliruiushchie autoantitela v krovi bol'nykh diffuznym toksicheskim zobom.