Adrenocortical changes and uptake of 4-14C-corticosterone in rats intoxicated with fenitrothion.
A significant increase in plasma corticosterone levels and depletion of ascorbic acid content in adrenal glands occurred in rats between 1 and 5 h after a single dose (50% LD50) of fenitrothion, returning to normal levels within 12 h; brain AChE activity decreased to about 59-43% and significant inhibition of the enzyme was observed for up to 24 h after intoxication. Repeated dosing with fenitrothion (2.5% LD50) for 14 days caused insignificant elevation of plasma corticosterone levels, while brain AChE activity was inhibited to about 19% of control values and uptake of 4-14C-corticosterone in tissues was significantly diminished.
Osicka-Koprowska
A
A
Department of Toxicology, Medical Academy Warsaw, Poland.
Gradowska-Olszewska
I
I
Wysocka-Paruszewska
B
B
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D003345:Corticosterone / Q000378:metabolism*; D005278:Fenitrothion / Q000506:poisoning*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution / Q000187:drug effects
D001205:Ascorbic Acid; D005278:Fenitrothion; D003345:Corticosterone