[Cytoarchitectonics of the tracheobronchial lymph nodes in rats exposed to carbon disulfide].
Cytoarchitectonics and rearrangement of cellular composition in functionally different zones of the rat tracheobronchial lymph nodes have been studied at a short effect of the industrial carbon disulfide vapour at a maximally admissible concentration (MAC) (1 mg/m3 and 10 mg/m3), as well as after the effect of MAC of carbon disulfide in the inhaled air for 4, 7, 14 days. The inhalation of the carbon disulfide vapours results in certain changes of the cytoarchitectonics of the lymph nodes studied in dependence on concentration and duration of the substance effect in the air inhaled. The effect of the MAC carbon disulfide, when the experiment lasts for 2 days, is accompanied with a decreased lymphocytopoiesis in all the structural components of the node and with a sharp intensification in the number of plasma cells of the medullary cords, that demonstrates local immunocytopoiesis. An opposite picture is noted, when carbon disulfide is applied in an elevated concentration (10 mg/m3)--plasmic reaction is sharply inhibited in the medullary cords, lymphocytopoiesis is noticeably increased, certain signs of allergic reaction are also seen. A prolonged effect of carbon disulfide vapours (up to 14 days) in MAC results in lymphocytopenia of the nodes, in increasing destructive processes and in decreasing cell proliferation. Differences in reaction of the structural components are revealed in the nodes studied at the toxic effect: in the cortical plateau and in the medullary cords suppression of the lymphocytopoietic activity is noted, and in the medullary cords--inhibition of immunocytopoiesis.
Grigorenko
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D000280:Administration, Inhalation; D000818:Animals; D001980:Bronchi / Q000166:cytology / Q000187:drug effects*; D002246:Carbon Disulfide / Q000633:toxicity*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008198:Lymph Nodes / Q000166:cytology / Q000187:drug effects*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014132:Trachea / Q000166:cytology / Q000187:drug effects*
D002246:Carbon Disulfide
Tsitoarkhitektonika trakheobronkhial'nykh limfaticheskikh uzlov krys pri vozdeĭstvii serougleroda.