Vitamin E and selenium status of guinea pigs with myocardial necrosis.
Myocardial necrosis and mineralization has been identified in a colony of guinea pigs which were subsequently tested for vitamin E and selenium deficiency. Serum vitamin E and whole blood selenium levels were within normal ranges. The erythrocyte glutathione peroxidase test has potential as a predictor of whole blood selenium levels in the guinea pig. The red blood cell hemolysis test used in this study did not correlate consistently with the serum vitamin E levels. We suspect that myocardial necrosis and mineralization may have resulted from inbreeding guinea pigs within the closed colony.
Department of Comparative Medicine, College of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
J W
JW
Griffith
C M
CM
Lang
D000818:Animals; D009202:Cardiomyopathies / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006168:Guinea Pigs; D006461:Hemolysis; D008297:Male; D009336:Necrosis; D011247:Pregnancy; D012376:Rodent Diseases / Q000097:blood* / Q000473:pathology; D012643:Selenium / Q000097:blood* / Q000172:deficiency; D014810:Vitamin E / Q000097:blood*; D014811:Vitamin E Deficiency / Q000662:veterinary
D014810:Vitamin E; D005979:Glutathione Peroxidase; D012643:Selenium