Vitamin E and selenium status of guinea pigs with myocardial necrosis.
Myocardial necrosis and mineralization has been identified in a colony of guinea pigs which were subsequently tested for vitamin E and selenium deficiency. Serum vitamin E and whole blood selenium levels were within normal ranges. The erythrocyte glutathione peroxidase test has potential as a predictor of whole blood selenium levels in the guinea pig. The red blood cell hemolysis test used in this study did not correlate consistently with the serum vitamin E levels. We suspect that myocardial necrosis and mineralization may have resulted from inbreeding guinea pigs within the closed colony.
Griffith
J W
JW
Department of Comparative Medicine, College of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Lang
C M
CM
D000818:Animals; D009202:Cardiomyopathies / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006168:Guinea Pigs; D006461:Hemolysis; D008297:Male; D009336:Necrosis; D011247:Pregnancy; D012376:Rodent Diseases / Q000097:blood* / Q000473:pathology; D012643:Selenium / Q000097:blood* / Q000172:deficiency; D014810:Vitamin E / Q000097:blood*; D014811:Vitamin E Deficiency / Q000662:veterinary
D014810:Vitamin E; D005979:Glutathione Peroxidase; D012643:Selenium