Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy.
We determined the in vitro survival parameters of 14 human head and neck squamous cell carcinoma tumor cell lines cultured from patients who suffered local failure after a curative course of radiotherapy. The radiobiological parameters determined included D, D0, n, and surviving fractions at 100, 200, and 300 cGy. When compared to in vitro radiobiological parameters of tumor cells cultured from head and neck cancer patients prior to radiotherapy, human sarcoma cell lines derived from patients not receiving therapeutic radiation, normal human diploid fibroblasts or other human tumor cell lines reported in the literature, the human tumor cells derived from radiotherapy failures are radioresistant.
Michael Reese/University of Chicago Center for Radiation Therapy, Department of Radiation Oncology, IL.
R R
RR
Weichselbaum
M A
MA
Beckett
J L
JL
Schwartz
A
A
Dritschilo
D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D002470:Cell Survival; D004307:Dose-Response Relationship, Radiation; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local; D011836:Radiation Tolerance; D014407:Tumor Cells, Cultured / Q000528:radiation effects