Linkage between the beta B2 and beta B3 crystallin genes in man and rat: a remnant of an ancient beta-crystallin gene cluster.
Human and rat genomic clones containing beta B2- and/or beta B3-crystallin sequences have been isolated and characterized. Both in the human and the rat genome the single-copy beta B3-crystallin gene is linked to a beta B2-crystallin gene. In both species the linked genes, separated by 20 kb in the human and 11 kb in the rat genome, are oriented head-to-tail with respect to transcription. A single copy of the beta B2-crystallin gene is present in the rat genome, in the human genome two copies of this gene are found. The second human copy could as yet not be linked to the beta B2/beta B3-crystallin gene cluster.
Laboratory of Molecular Biology, University of Nijmegen, The Netherlands.
H J
HJ
Aarts
J T
JT
Den Dunnen
N H
NH
Lubsen
J G
JG
Schoenmakers
D000818:Animals; D005075:Biological Evolution; D003001:Cloning, Molecular; D003459:Crystallins / Q000235:genetics*; D004247:DNA / Q000302:isolation & purification; D008040:Genetic Linkage; D006801:Humans; D051381:Rats
D003459:Crystallins; D004247:DNA