The behavioural response to the 5-hydroxytryptamine1B (5HT1B) receptor agonist--RU-24969 may exhibit a circadian variation in the mouse.
The effects of the 5-hydroxytryptamine1B receptor agonist RU-24969 on locomotor activity were examined at different times during the light-dark cycle in the mouse. A dose-dependent hyperlocomotion was observed following RU-24969 administration which was partially antagonised by the non-selective 5-hydroxytryptamine receptor antagonist metergoline. The dose ratios for RU-24969 at two different times tested (8 hr after lights-on, L8; 5 hr after lights-off, D5) were significantly different in the presence of metergoline (2 and 5 mg/kg i.p.). The data suggest that the receptor(s) involved in the behavioural response to RU-24969 in the mouse exhibit a circadian variation.
Department of Physiology and Pharmacology, Medical School, Nottingham, U.K.
K F
KF
Martin
A R
AR
Webb
C A
CA
Marsden
D000818:Animals; D002940:Circadian Rhythm; D004334:Drug Administration Schedule; D007211:Indoles / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*
D007211:Indoles; D008711:Metergoline; C025145:5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole