Abortifacient properties of an extract from Sida veronicaefolia.
A fraction from an alcoholic extract of Sida veronicaefolia, previously reported to be a potent oxytocic, was studied for its abortifacient effects in pregnant rats. Oral doses producing the abortifacient effects were greater than or equal to 32 ml/kg when administered from the 15th-17th day of pregnancy. Similar effects were produced by intravenous doses of greater than or equal to 3 ml/kg. At the minimum effective oral dose of 32 ml/kg, those animals that carried the conceptuses to term (40%) had litters with reduced average number/litter and weight. At twice this dose, only 10% delivered and the litters were sickly. The effects of intravenous administration of the extract was similar but more pronounced and included also some unique acute effects.
Department of Pharmacology, University of Science and Technology, Kumasi, Ghana.
G D
GD
Lutterodt
D000019:Abortifacient Agents; D000818:Animals; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005327:Fetal Resorption / Q000139:chemically induced; D010121:Oxytocin / Q000494:pharmacology; D010936:Plant Extracts / Q000633:toxicity*; D010946:Plants, Medicinal; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D000019:Abortifacient Agents; D010936:Plant Extracts; D010121:Oxytocin