Vancomycin entry into lung lymph in sheep.
The distribution of antibiotics into target tissues is a crucial factor in therapeutic efficacy. To estimate the availability of systemically administered vancomycin to the interstitial fluid in the lung, we have used a sheep model with a chronic pulmonary lymph fistula to collect simultaneously series of plasma and pulmonary lymph specimens during a 6-h period after an intravenous dose of vancomycin (7 mg/kg). After a minor delay in transit from blood to lymph, vancomycin was completely distributed to pulmonary lymph with a ratio of free drug in lymph to free drug in plasma of 0.9. This suggests that vancomycin is an excellent choice for treating pulmonary infections by susceptible organisms.
Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
D G
DG
May
C W
CW
Stratton
W D
WD
Denney
F L
FL
Watts
G R
GR
Bernard
R A
RA
Branch
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D008168:Lung / Q000378:metabolism*; D008196:Lymph / Q000378:metabolism*; D010539:Permeability; D011485:Protein Binding; D012756:Sheep; D014640:Vancomycin / Q000493:pharmacokinetics*
D001798:Blood Proteins; D014640:Vancomycin