Pregnancies of mothers with a neural tube defect child: outcomes and recurrence risks.
Ninety-four mothers who had been in contact with the Center for Human Genetics of the University of Leuven (Belgium) after the birth of a child with neural tube defect were questioned about the outcomes of their pregnancies. To this end a structured interview and a mailed questionnaire were used. The recurrence rate for neural tube defects after the birth of one affected child was 2.9%. This number is at the lower border of the risk rates (between 3% and 5%) generally given to parents during genetic counseling sessions. The relative amount of miscarriages was larger in the interviewed group than in the Belgian population in general.
Center for Human Genetics, University of Leuven.
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Swerts
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Evers-Kiebooms
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Van den Berghe
D000022:Abortion, Spontaneous; D001530:Belgium; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009436:Neural Tube Defects / Q000453:epidemiology* / Q000235:genetics; D011247:Pregnancy; D011256:Pregnancy Outcome; D012307:Risk Factors