Recurrent thromboembolism, disseminated intravascular coagulation, and coumarin-induced skin necrosis associated with protein C deficiency.
Defiency of protein C has been reported to be associated with recurrent thrombosis and pulmonary embolism, disseminated intravascular coagulation, and coumarin-induced skin necrosis and peripheral gangrene. That all of these serious and eventually lethal complications of protein C deficiency, including embolic myocardial infarction, may occur in the same person is the subject of this case report and description of pathological findings.
Department of Pathology, Mayo Clinic, Rochester, Minnesota.
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D000293:Adolescent; D001777:Blood Coagulation; D003374:Coumarins / Q000009:adverse effects*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D005260:Female; D005734:Gangrene / Q000209:etiology; D006801:Humans; D009206:Myocardium / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced; D020151:Protein C Deficiency; D011655:Pulmonary Embolism / Q000209:etiology; D012008:Recurrence; D012867:Skin / Q000473:pathology*; D013923:Thromboembolism / Q000209:etiology*
D003374:Coumarins; C030123:coumarin