Novel cholecystokinin antagonists from Aspergillus alliaceus. I. Fermentation, isolation, and biological properties.
The discovery and biological properties of four novel cholecystokinin antagonists produced by Aspergillus alliaceus is described. One of these was seven times more potent than the previously reported asperlicin.
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065.
M A
MA
Goetz
R L
RL
Monaghan
R S
RS
Chang
J
J
Ondeyka
T B
TB
Chen
V J
VJ
Lotti
D000818:Animals; D001230:Aspergillus / Q000378:metabolism*; D001570:Benzodiazepinones / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D005285:Fermentation; D051381:Rats
D001570:Benzodiazepinones; D002766:Cholecystokinin; C046367:asperlicin