Decrease of serum malondialdehyde in patients treated with chlorpromazine.
Malondialdehyde determination in serum from schizophrenic patients before and after treatment with chlorpromazine showed that, after treatment, patients had significantly lower values than before. The antioxidant properties of chlorpromazine can be related to its effect on the level of serum lipid peroxides and possibly to its neuroleptic action.
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Centro Studio Fisiologia Mitocondriale CNR, Vicenza, Italy.
Rigobello
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MP
Cavallini
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Dalla Libera
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D000328:Adult; D000368:Aged; D002746:Chlorpromazine / Q000009:adverse effects* / Q000627:therapeutic use; D003864:Depression, Chemical; D006801:Humans; D008297:Male; D008314:Malonates / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy; D013055:Spectrophotometry, Infrared
D008314:Malonates; D008315:Malondialdehyde; D002746:Chlorpromazine