The effects of two mutations connected with chromatin functions on female germ-line cells of Drosophila.
We have studied the developmental effects of two dominant suppressor mutations of position-effect variegation mutations on female germ-line cells. Su-var(2)1(01), which has been shown to affect chromatin structure though altering histone deacetylation, and Su-var(3)3(03) are recessive female steriles and zygotic lethals in the presence of butyrate or an additional Y chromosome. We have analysed mosaic females with mutant germ-line and normal soma and concluded that intact functions of the Su-var(2)1 and the Su-var(3)3 genes are required for development of both the soma and the germ-line and that as indirect evidence suggest, their maternally provided products are needed for normal embryonic development. It is suggested that there is possibly a common control of chromatin structure and gene expression in the soma, female germ-line and embryonic cells of Drosophila.
Szabad
J
J
Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged.
Reuter
G
G
Schröder
M B
MB
D000818:Animals; D002087:Butyrates / Q000494:pharmacology; D002678:Chimera; D002843:Chromatin / Q000502:physiology*; D004330:Drosophila / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D005854:Germ Cells / Q000502:physiology*; D007247:Infertility, Female / Q000235:genetics; D009154:Mutation; D013489:Suppression, Genetic
D002087:Butyrates; D002843:Chromatin