Including the environment in models for genetic segregation.
Current models for linkage and segregation analysis do not allow for many of the different ways in which the environment may affect risk for a psychiatric disorder. A variety of mechanisms for the contribution of the environment and the correlation and interaction of environment effects with genetic differences are described. The approach to including these effects in models for segregation and linkage is outlined.
Department of Human Genetics, Medical College of Virginia, Richmond 23298.
L J
LJ
Eaves
D005838:Genotype; D006801:Humans; D001523:Mental Disorders / Q000235:genetics* / Q000523:psychology; D008957:Models, Genetic; D012307:Risk Factors; D012931:Social Environment