Effects of hachimijiogan, tokishakuyakusan and keishibukuryogan on the corpus luteum function and weights of various organs in vivo.
27-day-old female rats received 20 IU PMS and 56 hours later, 40 IU hCG and were orally given with 20 or 200 micrograms of Hachimijiogan (TJ-7), Tokishakuyakusan (TJ-23) or Keishibukuryogan (TJ-25) daily for 3 or 5 days before sacrifice. Seven days after hCG treatment, the serum and ovarian tissue were assayed for progestins. 200 micrograms/day of TJ-23 significantly (p less than 0.05) decreased the progesterone and 17 alpha-hydroxyprogesterone levels, whereas it significantly (p less than 0.01) increased 20 alpha-hydroxyprogesterone. TJ-7 and TJ-25 showed a tendency to decrease these progestins. These results suggest that TJ-23 has a luteolytic effect on the corpus luteum in vivo.
Usuki
S
S
Department of Obstetrics and Gynecology, University of Tsukuba, Ibaraki, Japan.
D000818:Animals; D001565:Benzoates; D001952:Bridged-Ring Compounds; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003338:Corpus Luteum / Q000187:drug effects / Q000502:physiology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005960:Glucosides / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D006064:Gonadotropins, Equine / Q000494:pharmacology; D039821:Monoterpenes; D009929:Organ Size / Q000187:drug effects*; D009928:Organ Specificity; D010936:Plant Extracts / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001565:Benzoates; D001952:Bridged-Ring Compounds; D006063:Chorionic Gonadotropin; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D006027:Glycosides; D006064:Gonadotropins, Equine; D039821:Monoterpenes; D010936:Plant Extracts; C054591:hachimijiogan; C054593:keishibukuryogan; C015423:peoniflorin; D011374:Progesterone