Does the Schwann cell synthesize a molecule concentrated at the neuromuscular synapse?
The monoclonal antibody 6.17 binds to a molecule concentrated at the neuromuscular synapse. We tested it in various experimental conditions and all along the normal muscle development. It seems that the 6.17 corresponding antigen, suspected of Schwann cell origin, would be later localised in the synaptic space, but not in the basal lamina. Thus, the Schwann cell might participate to the synthesis of some synaptic molecules.
Koenig
J
J
Laboratoire Neurobiologie cellulaire, Université Bordeaux II, U.A. C.N.R.S., Talence, France.
Chapron
J
J
Vigny
M
M
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D000911:Antibodies, Monoclonal; D001485:Basement Membrane / Q000378:metabolism; D006493:Heparin / Q000031:analogs & derivatives / Q000378:metabolism; D007797:Laminin / Q000378:metabolism; D007908:Lens, Crystalline / Q000378:metabolism; D009121:Muscle Denervation; D024510:Muscle Development; D009132:Muscles / Q000294:innervation; D009416:Nerve Regeneration; D009469:Neuromuscular Junction / Q000378:metabolism*; D009994:Osmolar Concentration; D011509:Proteoglycans / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000378:metabolism; D012583:Schwann Cells / Q000378:metabolism* / Q000648:ultrastructure; D013569:Synapses / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D007797:Laminin; D011509:Proteoglycans; D011950:Receptors, Cholinergic; C036090:heparin proteoglycan; D006493:Heparin