Methylphenidate in primary obsessive-compulsive disorder.
An acute methylphenidate challenge was performed on 13 patients with primary obsessive-compulsive disorder. There was no overall effect of methylphenidate on mood or obsessive-compulsive behavior. However, on various behavioral scales, four patients had an antiobsessive-compulsive response and one patient an antidepressant response to methylphenidate. The clinical and theoretical implications of these findings are discussed.
Department of Psychiatry, St. Michael's Hospital, Toronto, Ontario, Canada.
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Joffe
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Swinson
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology
D008774:Methylphenidate