S-adenosyl-L-methionine prevents ischemic neuronal death.
The effect of S-adenosyl-L-methionine (SAM) on neuronal degeneration induced by transient forebrain ischemia was studied in rats. Bilateral occlusion of the common carotid arteries for 30 min in a 4-vessel occlusion model caused degeneration of CA1 neurons of the hippocampus. When SAM-HCl or SAM sulphate tosylate (SAM-ST, 100 mg/kg as the free form of SAM, i.p.) was administered just after recirculation and every hour for 5 h after recirculation, the degeneration and loss of pyramidal cells were prevented. However, adenosine, a metabolite of SAM, and glycerol, which has the same osmotic pressure as the solution of SAM-ST, did not show any effects on the neuronal damage. The results showed that SAM has a beneficial effect on neuronal damage induced by ischemia.
Matsui
Y
Y
Biological Research Laboratories, Sankyo Co. Ltd., Tokyo, Japan.
Kubo
Y
Y
Iwata
N
N
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D002470:Cell Survival / Q000187:drug effects; D006624:Hippocampus / Q000473:pathology; D008297:Male; D009410:Nerve Degeneration / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012436:S-Adenosylmethionine / Q000494:pharmacology*
D012436:S-Adenosylmethionine