The influence of proglumide, a putative CCK antagonist, on cerebral ischemia in gerbil.
Studies were conducted to clarify the possible role of CCK in cerebral ischemia and to evaluate the effects of proglumide, a competitive and reversible CCK antagonist, as a potential therapeutic or prophylactic tool in the treatment of cerebral ischemia. Proglumide at the doses of 10, 50 and 150 mg/kg was administered to gerbils before unilateral carotid ligation, and its effect on stroke index score, incidence and mortality rate was observed. Our results show that proglumide injected prior to carotid ligation at the dose of 150 mg/kg significantly reduces both incidence and mortality rate and changes the distribution of the stroke index score in gerbils. There was a significant inverse relationship between the dose of proglumide and both incidence and mortality: the greater the injection dose of proglumide, the lower the incidence and mortality. These results suggest that CCK may be involved in the pathological processes of cerebral ischemia and proglumide or related compounds prove to be effective in the pharmacological prophylaxis of ischemic brain damage.
Xu
C
C
Department of Neurochemistry, Beijing Neurosurgical Institute, People's Republic of China.
Xue
D
D
Su
M C
MC
Du
L F
LF
Gu
X
X
Yang
C L
CL
Liu
F
F
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control*; D002339:Carotid Arteries / Q000502:physiology; D002766:Cholecystokinin / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D005849:Gerbillinae; D005973:Glutamine / Q000031:analogs & derivatives*; D011377:Proglumide / Q000627:therapeutic use*; D013997:Time Factors
D005973:Glutamine; D002766:Cholecystokinin; D011377:Proglumide