[Effect of multiple peroral use of analgin on the liver monooxygenase system in the rat].
Analgin given repeatedly per os in dose 15 mg/kg to white male rats, causes changes in some indices of the liver NADPH-dependent mono-oxygenase system. At the end of the first month a decrease in the quantity of the microsomal protein was established as well as increase of the cytochrome's content P-450 and b5. The frequencies of cytochrome P-450-dependent biotransformations of substrates aminopyrine and aniline are also of different directions. At the end of the sixth month, because of multiple drug application all these indices are in the limits of the control values. A change in the catalytic features of cytochrome P-450, is established, which is expressed mainly by strongly decreased affinity to the substrates of first type. The Michaelis's constant Km for substrate aminopyrine depends on the duration of analgin introduction and increases up to 300% towards the control at the end of the sixth month.
M
M
Koleva
F
F
Kaloianova
V
V
Dobreva
S
S
Mitova
D000284:Administration, Oral; D000632:Aminopyrine / Q000031:analogs & derivatives*; D000818:Animals; D002384:Catalysis; D004177:Dipyrone / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010105:Oxygenases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000632:Aminopyrine; D004177:Dipyrone; D010105:Oxygenases
Vliianie na mnogokratno peroralno prilagane na analgin vŭrkhu chernodrobnata monooksigenazna sistema na plŭkhove.