Comparison of in vitro activity of niridazole, metronidazole and tetracycline against subgingival bacteria in chronic periodontitis.
Niridazole, metronidazole and tetracycline were compared for their activity against subgingival bacteria from patients with chronic periodontitis. Niridazole was consistently more effective than the other drugs against obligate anaerobes and exhibited some activity against facultative organisms. It was concluded that niridazole has potential for topical use in chronic periodontitis.
Department of Periodontology, Dental School, University of Wales College of Medicine, Heath Park, Cardiff, UK.
W G
WG
Wade
M
M
Addy
D001421:Bacteria, Anaerobic / Q000187:drug effects*; D003773:Dental Plaque / Q000382:microbiology; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology*; D009560:Niridazole / Q000494:pharmacology*; D010514:Periodontal Pocket / Q000382:microbiology*; D010518:Periodontitis / Q000188:drug therapy / Q000382:microbiology*; D013752:Tetracycline / Q000494:pharmacology*
D008795:Metronidazole; D013752:Tetracycline; D009560:Niridazole