Acetoxymethyl-methylnitrosamine (AMMN) induced colorectal carcinogenesis is stimulated by chronic alcohol consumption.
Chronic ethanol feeding together with the direct acting carcinogen AMMN led to an earlier occurrence of colorectal tumors in SD rats.
Garzon
F T
FT
Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
Simanowski
U A
UA
Berger
M R
MR
Schmähl
D
D
Kommerell
B
B
Seitz
H K
HK
D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced*; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004357:Drug Synergism; D000431:Ethanol / Q000009:adverse effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012004:Rectal Neoplasms / Q000139:chemically induced*
D000431:Ethanol; C014659:methyl(acetoxymethyl)nitrosamine; D004128:Dimethylnitrosamine