[Clinical evaluation of local infusion chemotherapy in metastatic liver carcinoma].
Twenty patients with metastatic carcinoma of liver were treated with infusion chemotherapy using Port-A-Cath or Infuse-A-Port; canulae were surgically inserted into hepatic artery and/or portal vein, and ports were implanted into subcutaneous pockets. Selection of chemotherapeutic agents was made on the basis of subrenal capsule assay (SRCA) and in vivo chemo-sensitivity test, developed by A. E. Bogden et al., 1987. The results were as follows: 1. Implantation of catheter is beneficial as a maintenance chemotherapy for patients with metastatic liver carcinoma, because of its safety and the improved quality of life. 2. One patient canulated into portal vein, showed partial response. 3. In this prospective study of subrenal capsule assay, true positive rate was 50% (3/6), true negative rate 100% (4/4), and overall predictive accuracy was 70% (7/10). The present study suggested that SRCA is useful for selecting effective anti-tumor agents for treatment of metastatic liver cancer patients.
2nd Dept. of Surgery, Hyogo College of Medicine.
E
E
Yokoyama
M
M
Miura
M
M
Shirakabe
J
J
Haneda
T
T
Kusunoki
J
J
Utsunomiya
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology; D006499:Hepatic Artery; D006801:Humans; D007260:Infusion Pumps; D007261:Infusions, Intra-Arterial / Q000379:methods; D007262:Infusions, Intravenous / Q000379:methods; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D011237:Predictive Value of Tests; D013370:Subrenal Capsule Assay
D000970:Antineoplastic Agents