Cross-protection factor(s) of Pasteurella multocida: passive immunization of turkeys against fowl cholera caused by different serotypes.
An antiserum cross-protective against different serotypes of Pasteurella multocida was made in turkeys by inoculating them with killed serotype 3 organisms grown in vivo and then exposing them to live serotype 3 organisms. In passive-immunization studies, the antiserum protected young turkeys against the homologous and heterologous serotypes 1, 4, 5, 9, and 12. In addition, the antiserum protected against P. multocida of a heterologous capsule serogroup, serogroup F. A globulin and two IgG fractions purified from the antiserum protected against heterologous challenge with serotype 1. Turkey-grown P. multocida were chemically lysed and separated into soluble and insoluble components to make immunoadsorbents. Antibodies from the cross-protective antiserum isolated by the immunoadsorbents passively protected young turkeys against heterologous serotype I challenge.
National Animal Disease Center, Ames, Iowa 50010.
R B
RB
Rimler
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000917:Antibody Formation; D007116:Immunization, Passive / Q000662:veterinary*; D010325:Pasteurella / Q000145:classification; D010326:Pasteurella Infections / Q000276:immunology / Q000662:veterinary*; D011201:Poultry Diseases / Q000276:immunology*; D012703:Serotyping; D014422:Turkeys / Q000276:immunology*
D000907:Antibodies, Bacterial