[Antitumor activity of CPT-11 against rat Walker 256 carcinoma].
The antitumor activity of CPT-11 on rat Walker 256 carcinoma was investigated. Intraperitoneal, intravenous or oral administration of CPT-11 caused a remarkable prolongation of the life span of Wistar rat implanted with Walker 256 intraperitoneally. Intravenous injection and oral administration of CPT-11 markedly inhibited the growth of subcutaneously implanted Walker 256. CPT-11 showed a considerable antitumor activity by continuous intravenous injection against the solid type Walker 256.
Yakult Central Institute for Microbiological Research.
T
T
Furuta
T
T
Yokokura
M
M
Mutai
D000284:Administration, Oral; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002279:Carcinoma 256, Walker / Q000188:drug therapy* / Q000473:pathology; D007262:Infusions, Intravenous; D007263:Infusions, Parenteral; D000077146:Irinotecan; D051381:Rats
D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D002166:Camptothecin