[Absence of HL-A homology in couples presenting repeated miscarriages. Trials with multidonor transfusions].
Maternal tolerance of the fetus involves maternal immuno-regulating mechanisms. The genetic control of this immune response depends on the HL-A system. An extreme HL-A antigenic community between parents might cause a decreased immune response and increased miscarriages. Contrary to some studies from the literature, in our experience, HL-A homology in couples with recurrent miscarriages does not seem significant. This absence of homology may be explained by an extreme polymorphism of HL-A antigens identified and isolated every year. The role of maternal blocking antibodies in maternal tolerance of the fetus is also discussed. The results of a protocol of multi-donor transfusions in 8 patients, is presented and reviewed according to the resulting pregnancies and data from the literature.
Clinique Obstétricale, Hôpital Edouard Herriot, Lyon.
L
L
Gebuhrer
G
G
Mellier
M
M
Doillon
J M
JM
Thoulon
H
H
Bétuel
D000026:Abortion, Habitual / Q000276:immunology* / Q000628:therapy; D001782:Blood Donors; D001803:Blood Transfusion; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy
D006680:HLA Antigens
Absence d'homologie HL-A dans les couples présentant des fausses-couches à répétition. Essais de transfusions multidonneurs.