In vitro testing of the anti-mycoplasma effect of some anti-coccidial drugs.
The anti-mycoplasma effects of the ionophores (lasalocid sodium, monensin and nigericin) were compared with that of tylosin tartrate and tiamulin in vitro. Forty-four strains representing 14 avian and 10 mammalian Mycoplasma species and serotypes and 5 Acholeplasma species were tested. The ionophores showed average minimal inhibitory concentration (MIC) values between 3.65 and 4.93 micrograms ml-1 for all strains, the MIC values for glucose-fermenting strains were between 2.26 and 3.75 micrograms ml-1, significantly lower than for arginine-hydrolysing strains (9.27-13.12 micrograms ml-1). These values were significantly higher than those obtained with tylosin tartrate (0.45 micrograms ml-1) or tiamulin (0.13 micrograms ml-1). The ionophores were more efficacious against acholeplasmas (0.06-0.25 micrograms ml-1) than against mycoplasmas.
Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest.
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L
Stipkovits
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T
Kobulej
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Z
Varga
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S
Juhász
D000127:Acholeplasma / Q000187:drug effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003049:Coccidiostats / Q000494:pharmacology*; D004224:Diterpenes / Q000494:pharmacology; D007476:Ionophores / Q000494:pharmacology*; D007832:Lasalocid / Q000494:pharmacology; D007933:Leucomycins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008985:Monensin / Q000494:pharmacology; D009174:Mycoplasma / Q000187:drug effects*; D009550:Nigericin / Q000494:pharmacology; D015645:Tylosin
D000900:Anti-Bacterial Agents; D003049:Coccidiostats; D004224:Diterpenes; D007476:Ionophores; D007933:Leucomycins; D008985:Monensin; C014224:tiamulin; D009550:Nigericin; D007832:Lasalocid; D015645:Tylosin