Regulation of recovery in the erythroid lineage: model studies.
Based on data from the literature, the major regulatory features were established for the erythroid population regenerating after perturbation. A mathematical model is proposed which takes into account: (1) the increase in the proliferating CFU-S due to depopulation of CFU-S and BFU-E/8 pools due to increased migration caused by erythropoietin; (2) regeneration of erythroid precursors due to short-range factors and (3) gradual reduction in the short-range effects and increase in the humoral influence on BFU-E/8, BFU-E/3 and CFU-E together with short-range suppression of progenitor differentiation and acceleration of maturation in all subpopulations due to humoral factors. The kinetics of subpopulations as a function of feedback and maturation rate are analysed. The dependence of erythrocyte production on erythrocyte depletion in the blood and on the feedback coefficient is defined.
Institute of Biological Physics, U.S.S.R. Academy of Sciences, Moscow Region.
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VG
Tyazhelova
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D004900:Erythroblasts / Q000166:cytology; D004912:Erythrocytes / Q000166:cytology*; D004920:Erythropoiesis; D004921:Erythropoietin / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D007700:Kinetics; D008433:Mathematics; D051379:Mice; D008954:Models, Biological; D013154:Spleen / Q000166:cytology
D004921:Erythropoietin