[Diffusion of 5-fluorocytosine in bronchial secretions in patients with respiratory insufficiency].
The 5-Fluorocytosine bronchial secretion levels of 14 patients with a chronic respiratory disease were determined using a microbiological method. The mean maximal concentrations (7.76 +/- 7 micrograms/ml) were obtained at the end of a single 25 mg/kg i v perfusion over 30 minutes. The level increased when five i v perfusions were performed every 6 hours and bronchial diffusion was higher and faster by concomitant administration of (bromhexin hydrochloride). Therefore, 5-Fluorocytosine was not found in bronchial secretions of four patients in spite of a normal serum levels (21.5 +/- 5 micrograms/ml).
Laboratoire de Parasitologie, Hôtel-Dieu, Rouen.
P
P
Brasseur
G
G
Bonmarchand
F
F
Caron
F
F
Lecomte
J
J
Leroy
G
G
Humbert
D001980:Bronchi / Q000378:metabolism*; D005260:Female; D005437:Flucytosine / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012131:Respiratory Insufficiency / Q000188:drug therapy* / Q000378:metabolism
D005437:Flucytosine
Diffusion de la 5-fluorocytosine dans les sécrétions bronchiques chez l'insuffisant respiratoire.