Hyperfiltration due to amino and keto acid supplements of low-protein diets: influence on creatinine clearance.
In 12 male 5/6 nephrectomized Sprague-Dawley rats we analyzed the influence of commercially available amino/keto acid supplements on creatinine clearance. The addition of different supplements to an 8% protein diet resulted in an increase of creatinine clearance. Keto acids per se do not seem to cause a remarkable increase in creatinine clearance/hyperfiltration. Our data underline the importance of the protein content of a low-protein diet and the composition of amino/keto acid supplements, as these factors per se can cause hyperfiltration and might accelerate progression of chronic renal failure.
Clinic of Nephrology, University of Heidelberg, Klinikum Mannheim, FRG.
N
N
Gretz
E
E
Meisinger
M
M
Strauch
D000601:Amino Acids, Essential / Q000008:administration & dosage*; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005527:Food, Fortified; D005919:Glomerular Filtration Rate; D007651:Keto Acids / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000601:Amino Acids, Essential; D004044:Dietary Proteins; D007651:Keto Acids; D003404:Creatinine