Cell-cell interactions in the eicosanoid pathway.
In vitro experiments carried out in several laboratories indicate that cell components of hemostatic plugs, thrombi, and inflammatory lesions are capable of sharing precursors and intermediates of both the lipoxygenase and cyclooxygenase systems. These cells produce new eicosanoids in a stimulus-specific manner. It is therefore important to further elucidate mechanisms by which eicosanoids are formed during cell-cell interactions and the functional implications thereof.
Marcus
A J
AJ
Department of Medicine, New York Veterans Administration Medical Center, Cornell University Medical College, New York 10010.
Safier
L B
LB
Ullman
H L
HL
Islam
N
N
Broekman
M J
MJ
Falck
J R
JR
Fischer
S
S
von Schacky
C
C
D000818:Animals; D001095:Arachidonic Acids / Q000097:blood*; D001792:Blood Platelets / Q000502:physiology*; D002450:Cell Communication; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D006801:Humans; D009504:Neutrophils / Q000502:physiology*; D013917:Thrombin / Q000502:physiology
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D013917:Thrombin