Antiparkinsonian activity and behavioural effects of newer quinazolinones.
Sixteen new compounds 2-methylamino substituted phenyl-3-substituted anilino 4 (3H) quinazolinones (3-18) were prepared. All the compounds were evaluated for their antiparkinsonian activity and compared with bromocriptine. Compounds 10,15 and 18 showed better activity. These compounds also bind with the dopamine receptors in striatal membrane preparations of rat brain.
Department of Pharmacology and Therapeutics, King George's Medical College, Lucknow, India.
V K
VK
Srivastava
G
G
Palit
A K
AK
Agarwal
K
K
Shanker
D000818:Animals; D000978:Antiparkinson Agents / Q000138:chemical synthesis / Q000378:metabolism; D001522:Behavior, Animal / Q000187:drug effects*; D001971:Bromocriptine / Q000494:pharmacology; D002389:Catatonia / Q000139:chemically induced; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011799:Quinazolines / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism; D014202:Tremor / Q000139:chemically induced
D000978:Antiparkinson Agents; D011799:Quinazolines; D011954:Receptors, Dopamine; D001971:Bromocriptine