Variations of susceptibility to alloxan induced diabetes in the rabbit.
The variations of susceptibility to alloxan induced Diabetes in a total of seventeen rabbits was described. Our study was designed to explore dosage schedules which might improve rabbit responsiveness to and survival after alloxan treatment. A wide range of response to intravenously administered alloxan was observed. Permanent diabetes (blood glucose 350 mg/dl) was found in three rabbits after a single injection (60 mg/kg in one, 100 mg/kg in two). This effect has persisted for eight months. By contrast, two other rabbits injected with a single dose of alloxan (60 mg/kg) developed only transient hyperglycemia. Similarly, four other rabbits either did not respond or had an incomplete response after receiving a total dose of 120 mg/kg. These data suggest that there is extreme variability in individual rabbits susceptibility to the diabetogenic affects of alloxan.
State University of New York Downstate Medical Center, Brooklyn.
Z H
ZH
Zhao
B
B
Watschinger
C D
CD
Brown
M M
MM
Beyer
E A
EA
Friedman
D000496:Alloxan / Q000008:administration & dosage; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced*; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D004334:Drug Administration Schedule; D006943:Hyperglycemia / Q000139:chemically induced; D008297:Male; D011817:Rabbits
D000496:Alloxan