[Radioprotective efficacy of acyl hydrazones].
As was shown in experiments with rats and mice some acyl hydrazones have a pronounced radioprotective effect. The protective efficiency makes 40-55 per cent with the preparation doses of 1-10 mg/kg. The toxicity of hydrazones is 2 g/kg which is lower, than that of the known sulfur-containing agents and substituted indolylalkylamines. The radio-protective efficiency of the drug depends on its complex-forming ability.
O V
OV
Arapov
O F
OF
Alferova
E I
EI
Levocheskaia
I I
II
Krasil'nikov
D000818:Animals; D006835:Hydrazones / Q000138:chemical synthesis / Q000627:therapeutic use* / Q000633:toxicity; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000138:chemical synthesis / Q000627:therapeutic use* / Q000633:toxicity
D006835:Hydrazones; D011837:Radiation-Protective Agents
Radiozashchitnaia éffektivnost' atsilgidrazonov.