[Combined treatment of patients with metastases of skin melanoma using cryotherapy].
Cryotherapy or cryotherapy plus intratumoral injection of BCG vaccine were used in combination with either prospidin or imidazole-carboxamide and multidrug chemotherapy including vincristine, dactinomycin and CCNU for the treatment of 106 cases of cutaneous and subcutaneous metastases of skin malignant melanoma. Five-year survival for the entire group was 36 +/- 5.1%. The best results were obtained for prospidin (43.6 +/- 8.6%) (imidazole-carboxamide--31.3 +/- 9.4% and combined chemotherapy--30.5 +/- 5.8%). Imidazole-carboxamide should be used in conjunction with cryotherapy plus intratumoral BCG vaccine. Procedure of topical treatment did not significantly influence the effectiveness of prospidin or combination chemotherapy.
Iavorskiĭ
V V
VV
Karaseva
V V
VV
Tokareva
Z I
ZI
D000620:Aminoimidazole Carboxamide / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001500:BCG Vaccine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003452:Cryosurgery; D003609:Dactinomycin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D009362:Neoplasm Metastasis; D011447:Prospidium / Q000008:administration & dosage; D012878:Skin Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D014750:Vincristine / Q000008:administration & dosage
D001500:BCG Vaccine; D003609:Dactinomycin; D000620:Aminoimidazole Carboxamide; D014750:Vincristine; D011447:Prospidium
Kompleksnoe lechenie bol'nykh s metastazami melanomy kozhi s ispol'zovaniem krioterapii.