Contents of cystathionine and taurine in various cerebellar regions of DL-propargylglycine-treated rats.
The contents of cystathionine and taurine, as well as cystathionine beta-synthase activity, in various cerebellar regions and pineal body of normal and DL-propargylglycine-treated rats were measured. The contents of cystathionine and taurine were found to be distributed unevenly in cerebellar regions of brain of both normal and DL-propargylglycine-treated rats. The content of cystathionine in each cerebellar region and pineal body increased gradually when the dose of DL-propargylglycine was increased from 10 mg to 30 mg per 200 g body weight. On the other hand, taurine content in each cerebellar region and pineal body decreased with the administration of 30 mg of DL-propargylglycine per 200 g body weight. The contents of cystathionine and taurine were greater in the pineal body than in various cerebellar regions. The activity of cystathionine beta-synthase was also distributed unevenly in various cerebellar regions of normal rat brain, and was unaltered following treatment of rats with DL-propargylglycine.
Department of Chemistry, Kochi Medical School, Japan.
H
H
Kodama
K
K
Sasaki
N
N
Mizobuchi
R
R
Kikuchi
D000480:Alkynes; D000818:Animals; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism*; D003540:Cystathionine / Q000378:metabolism*; D003541:Cystathionine beta-Synthase / Q000378:metabolism; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D010293:Pargyline / Q000031:analogs & derivatives* / Q000494:pharmacology; D010870:Pineal Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000378:metabolism*; D014018:Tissue Distribution
D000480:Alkynes; D013654:Taurine; D003540:Cystathionine; C009055:propargylglycine; D010293:Pargyline; D003541:Cystathionine beta-Synthase; D005998:Glycine