[Protection and latent and patent sensitization by nucleotides of radiation-induced transformations of gylcyltryptophan and serum albumin].
A study was made of the influence of nucleotides (AMP, GMP, UMP, and CMP) on x-ray chemiluminescence of glycyltryptophan and serum albumin solutions in humans. The coefficient of modification of radiation transformations of peptide (10(-4) M) and protein (1.47.10(-4) M) was shown to be a function of nucleotide concentration representing smooth curves with a plateau at the nucleotide concentration of above 2.10(-3) M. The extreme values of the modification coefficient vary from 0.35 to 2.18 and from 1 to 2 for peptide and protein respectively. The experimental data follow the kinetic mechanism suggesting that the protective effect is implemented by the nucleotide reactions with hydroxyl radicals whereas sensitization is implemented by the reactions of free radical nucleotides with peptide and protein molecules.
Kaplunskiĭ
G D
GD
Sapezhinskiĭ
I I
II
D004151:Dipeptides / Q000493:pharmacokinetics / Q000528:radiation effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005609:Free Radicals; D006801:Humans; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D009711:Nucleotides / Q000493:pharmacokinetics / Q000494:pharmacology*; D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents; D012709:Serum Albumin / Q000493:pharmacokinetics / Q000528:radiation effects*; D012996:Solutions
D004151:Dipeptides; D005609:Free Radicals; D009711:Nucleotides; D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents; D012709:Serum Albumin; D012996:Solutions; C032120:glycyltryptophan
Zashchita, skrytaia i iavnaia sensibilizatsiia nukleotidami radiatsionnykh prevrashcheniĭ glitsiltriptofana i syvorotochnogo al'bumina.