[Effects of cefotaxime on the coagulation system, especially their dependence on vitamin K-related factors].
The authors administered cefotaxime to 20 children and studied laboratory parameters concerning peripheral blood: hemoglobin count, blood platelet count, red blood cell count, and hematocrit value, and the coagulation system: protein induced by vitamin K deficiency or by the presence of a vitamin K antagonist II (PIVKA II), hepaplastin test (HPT), prothrombin time (PT) and active partial thromboplastin time (APTT). The results obtained are summarized as follows: 1. Peripheral blood No abnormal values were observed. 2. Coagulation system (1) PIVKA II: In all cases, PIVKA II was negative. (2) HPT, PT and APTT: In all cases, no significant changes of these values which would suggest the tendency for prolonged bleeding were observed.
Nishimura
T
T
Department of Pediatrics, Osaka Medical College.
Tabuki
K
K
Motohiro
T
T
Shimada
Y
Y
Takajo
N
N
Nagayama
K
K
Araki
H
H
Iwai
N
N
Miyatsu
M
M
Nakamura
H
H
D000293:Adolescent; D001424:Bacterial Infections / Q000097:blood* / Q000188:drug therapy; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D002439:Cefotaxime / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D014812:Vitamin K / Q000037:antagonists & inhibitors / Q000502:physiology*
D014812:Vitamin K; D002439:Cefotaxime