Common duct carcinoma and obstruction in female hamsters treated with N-nitrosobis(2-oxopropyl)amine and/or cholecystectomy.
Detailed histologic observations were performed on the head of the pancreas of hamsters treated with 10 mg/kg body weight N-nitrosobis(2-oxopropyl)amine (BOP) once a week for 6 weeks with or without cholecystectomy. Cholecystectomy was performed 5 weeks before starting BOP initiation. The incidence of head cancers was 100% and cholecystectomy did not affect pancreatic carcinogenesis by BOP. Common bile duct dilatation was produced by advanced pancreatic head carcinomas and microadenocarcinomas in common duct. Micro-adenocarcinomas were not macroscopically detected since the tumors were located in the lumen of common duct.
First Department of Surgery, Juntendo University, School of Medicine, Tokyo, Japan.
T
T
Kamano
A
A
Katami
J
J
Tamura
N
N
Azuma
Y
Y
Mori
T
T
Makino
K
K
Mizumoto
Y
Y
Konishi
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000209:etiology / Q000473:pathology; D000818:Animals; D002763:Cholecystectomy / Q000009:adverse effects*; D002779:Cholestasis / Q000209:etiology / Q000473:pathology*; D003135:Common Bile Duct / Q000473:pathology*; D003138:Common Bile Duct Neoplasms / Q000139:chemically induced* / Q000209:etiology / Q000473:pathology; D006224:Cricetinae; D005260:Female; D008647:Mesocricetus; D009602:Nitrosamines / Q000633:toxicity*
D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine