Several distinct "CCAAT" box binding proteins coexist in eukaryotic cells.
Even though a "CCAAT" box element is localized approximately equal to 80 base pairs upstream of the transcription initiation site in many eukaryotic promoters, it is not recognized by a single ubiquitous transcription factor. We show here that such a sequence present in the rat albumin promoter binds a protein distinct from the CCAAT-binding transcription factor CTF/NFI or from the CCAAT-binding protein (CBP) previously described. The protein binding to the albumin CCAAT sequence (ACF or albumin CCAAT factor) is not exclusive to liver, since we found a protein with identical properties in spleen.
Department of Molecular Biology, Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France.
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M
Raymondjean
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Cereghini
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Yaniv
D000418:Albumins / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D004268:DNA-Binding Proteins / Q000302:isolation & purification / Q000378:metabolism*; D008099:Liver / Q000032:analysis; D008297:Male; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D051381:Rats; D011919:Rats, Inbred Strains; D014157:Transcription Factors / Q000378:metabolism*
D000418:Albumins; D004268:DNA-Binding Proteins; D014157:Transcription Factors