Picogram level determination of fluphenazine in human plasma by automated gas chromatography/mass selective detection.
An automated capillary column gas chromatography electron-impact mass selective detection method has been developed for the determination of a major tranquilizing agent, fluphenazine. Using a new purification method and incorporating a deuterated internal reference, a limit of quantitation of 50 pg per ml of plasma was obtained.
Jemal
M
M
Squibb Institute for Medical Research, Analytical R&D Department, New Brunswick, New Jersey 08903.
Ivashkiv
E
E
Both
D
D
Koski
R
R
Cohen
A I
AI
D005476:Fluphenazine / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007202:Indicators and Reagents
D007202:Indicators and Reagents; D005476:Fluphenazine