Age- and body-weight-dependent changes in the reactivity to histamine of the airways smooth muscles in cats.
The relation between age and body weight and the reactivity to histamine of the tracheopulmonary contractile tissues was studied in cats in vitro. The reactivity of the tracheal smooth muscle to histamine decreased with increasing age from the newborn (100%) and one-month-old (57%) to the adult (0%) cat, whereas the amplitudes of contractions of lung strips increased. The amplitudes in adult animals also increased moderately with increasing body weight.
Visnovský
P
P
Department of Pathophysiology and Pharmacology, Faculty of Medicine, Comenius University, Martin, Czechoslovakia.
Bánovcin
P
P
Korpás
J
J
D000375:Aging / Q000187:drug effects*; D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D001835:Body Weight; D002415:Cats; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects; D008297:Male; D014132:Trachea / Q000187:drug effects
D006632:Histamine