The limits of ascertainment.
The concept of a proband, and a formula frequently used to give the probability that a family with r affected children has t probands, have led to frequently used, but incorrect, 'limits of ascertainment' in estimation problems involving ascertainment sampling. Data suggesting a sampling scheme outside these incorrect limits are discussed. An estimation procedure not using the proband concept is available which is not bounded by the incorrect limits.
Ewens
W J
WJ
Department of Mathematics, Monash University, Clayton, Victoria, Australia.
Shute
N C
NC
D002648:Child; D003198:Computer Simulation; D003625:Data Collection; D006801:Humans; D008957:Models, Genetic; D011336:Probability