Erythrocyte fatty acid profiles in patients with bronchogenic carcinoma.
The use of the erythrocyte stearic:oleic acid ratio in the diagnosis and prognosis of bronchogenic carcinoma has been assessed. Although there was a significant difference (P less than 0.02) in the erythrocyte stearic:oleic acid ratio between bronchogenic carcinoma patients and healthy adults, the large overlap observed in the two groups rendered the test unsuitable for the diagnosis of malignancy. Furthermore, there was no consistent rise in this ratio after surgical resection, indicating the test to be of little prognostic use. A new explanation for the lower stearic:oleic acid ratios in certain patients has been postulated.
Department of Clinical Chemistry, East Birmingham Hospital, UK.
A
A
Taylor
A
A
Manche
I
I
Wilson
D
D
Watson
H
H
Pandov
N
N
Lawson
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001984:Bronchial Neoplasms / Q000097:blood; D002283:Carcinoma, Bronchogenic / Q000097:blood*; D004912:Erythrocytes / Q000032:analysis*; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged
D014408:Biomarkers, Tumor; D005227:Fatty Acids