Effects of prazosin and indomethacin on the alpha-adrenergic stimulation of rabbit myometrium.
The effect of norepinephrine (NE) stimulation of near-term pregnant rabbit myometrium was studied by comparing cumulative dose-response curves for NE and NE with prazosin or indomethacin. Prazosin blocked the stimulatory effects of NE. Indomethacin pretreatment resulted in attenuation, but not suppression of contractile activity. Myometrial activity was associated with a progressive increase in the synthesis of prostaglandin (PG) F2 alpha. Our observations suggest that alpha-adrenergic agonists have some myometrial stimulating effect independent of PG production.
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
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Barss
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Phillippe
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Valles
D000818:Animals; D015237:Dinoprost; D005260:Female; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D011224:Prazosin / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D011460:Prostaglandins F / Q000096:biosynthesis; D011817:Rabbits; D014590:Uterine Contraction / Q000187:drug effects*
D011460:Prostaglandins F; D015237:Dinoprost; D009638:Norepinephrine; D011224:Prazosin; D007213:Indomethacin