Power and robustness of the linkage homogeneity test in genetic analysis of common disorders.
The power and robustness of the admixture test are studied. The power of the test depends on the genetic parameters at the disease locus. In particular, the power decreases drastically with the level of penetrance. The test is robust to errors in genetic parameters provided that the recombination fraction is not fixed a priori. However, misspecifying genetic parameters leads to a bias in the estimates of both the recombination fraction and the proportion of linked families.
I.N.S.E.R.M. U.155, Château de Longchamp, Bois de Boulogne, Paris, France.
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Clerget-Darpoux
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Babron
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Bonaïti-Pellié
D002874:Chromosome Mapping; D008040:Genetic Linkage; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D008957:Models, Genetic; D011995:Recombination, Genetic; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014960:X Chromosome