Antitumor activity of lipopolysaccharide and radio-detoxified lipopolysaccharide of Vibrio parahaemolyticus.
The antitumor activity of lipopolysaccharide (LPS) and radio-detoxified LPS of Vibrio parahaemolyticus was tested against S180 cells in Swiss mice. The toxicity of the LPS was 200 times less than that of Salmonella typhimurium LPS. The V. parahaemolyticus LPS could be detoxified by exposure to gamma radiation. Both LPS and the irradiated LPS exhibited antitumor activity, though the irradiated LPS was less effective than the native LPS. These observations indicated that exposure to gamma radiation caused significant detoxification of V. parahaemolyticus LPS and the detoxified LPS still possessed considerable antitumor activity.
Food Technology and Enzyme Engineering Division, Bhabha Atomic Research Centre, Bombay, India.
J R
JR
Bandekar
D P
DP
Nerkar
D000818:Animals; D005720:Gamma Rays; D008070:Lipopolysaccharides / Q000032:analysis / Q000528:radiation effects / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D012510:Sarcoma 180 / Q000628:therapy*; D013400:Sugar Acids / Q000032:analysis; D014736:Vibrio parahaemolyticus / Q000032:analysis / Q000378:metabolism*
D008070:Lipopolysaccharides; D013400:Sugar Acids; C002532:2-keto-3-deoxyoctonate