Immunochemotherapy of bladder carcinoma with glucan and cyclophosphamide.
Recent evidence suggests a role for both immunotherapy and chemotherapy in the treatment of transitional cell carcinoma. Glucan, a derivative of the cell wall of Saccharomyces cerevisiae and a potent immunostimulant, was used in combination with cyclophosphamide for treatment of implanted murine transitional cell carcinoma (MBT 2). Cyclophosphamide prevented tumor appearance when tumor burden was low and decreased tumor growth rate in larger tumor volumes, but was unable to eradicate established tumors. Glucan did not reduce tumor incidence but decreased animal mortality. These experimental observations may correlate well with clinical evidence and suggest future clinical use of these agents.
Department of Surgery, Brooke Army Medical Center, Fort Sam Houston, Texas 78234-6200.
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Thompson
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Spence
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Lamm
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DiLuzio
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005936:Glucans / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy; D008055:Lipids / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*
D000959:Antihypertensive Agents; D005936:Glucans; D008055:Lipids; C050534:medullipin I; D003520:Cyclophosphamide