Depression of lymphocyte response to mitogens in sheep infected with tick-borne fever.
Lymphocytes obtained from sheep experimentally infected with Cytoecetes phagocytophila, the causative agent of tick-borne fever, showed reduced blastogenesis induced by the mitogens phytohaemagglutinin and E. coli lipopolysaccharide. The period of reduced lymphocyte reactivity coincided with the period of parasitaemia and leucopenia.
Woldehiwet
Z
Z
University of Liverpool, Department of Veterinary Pathology, Leahurst, Neston, Wirral, U.K.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004536:Ehrlichia; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D008297:Male; D008623:Mercaptoethanol / Q000494:pharmacology; D008934:Mitogens / Q000494:pharmacology; D010835:Phytohemagglutinins / Q000494:pharmacology; D012288:Rickettsiaceae Infections / Q000276:immunology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology*
D008070:Lipopolysaccharides; D008934:Mitogens; D010835:Phytohemagglutinins; D008623:Mercaptoethanol; D004247:DNA