Respiratory stimulant effects of adenosine in man after caffeine and enprofylline.
In a double-blind and randomized study the respiratory stimulant effect of continuous intravenous adenosine infusion was studied after previous administration of caffeine, placebo and enprofylline in 10 healthy young volunteers. After placebo, adenosine induced an increase of minute ventilation (from 6.3 to 12.5 l min-1), tidal volume (from 0.60 to 0.96 l), and breathing rate (from 11.0 to 14.8 min-1). Venous pCO2 fell and pH rose after adenosine. Caffeine significantly reduced the adenosine-induced changes of minute ventilation, tidal volume, venous pCO2 and pH, whereas no changes occurred after enprofylline. Our results suggest that adenosine stimulates respiration in man by binding with specific P1-purinoceptors, which can be blocked by caffeine, but not by enprofylline.
Smits
P
P
Department of Internal Medicine, St Radboud Hospital, University of Nijmegen, The Netherlands.
Schouten
J
J
Thien
T
T
D000241:Adenosine / Q000494:pharmacology*; D000328:Adult; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002110:Caffeine / Q000097:blood / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D012119:Respiration / Q000187:drug effects*; D012129:Respiratory Function Tests; D013268:Stimulation, Chemical; D014970:Xanthines / Q000494:pharmacology*
D001993:Bronchodilator Agents; D014970:Xanthines; D002110:Caffeine; C034347:enprofylline; D000241:Adenosine