Effects of Forssman antibody on renal function of the guinea pig.
When guinea pigs were injected with rabbit anti-sheep red blood cell antiserum (Forssman antibody) by the intra arterial (i.a.) route (abdominal aorta at the level of the renal arteries), they developed renal disfunction. A diminished glomerular filtration rate associated with a 27% increase in the fractional excretion of K+ was observed. No alterations were noted in the fractional excretion of water and NA+.
Dept. of Parasitology, Medical School of Ribeirão Preto, Univesity of São Paulo, SP-Brazil.
J E
JE
Barbosa
W
W
Sarti
G B
GB
Mello
D000818:Animals; D000910:Antibodies, Heterophile / Q000008:administration & dosage*; D005919:Glomerular Filtration Rate; D006168:Guinea Pigs; D007674:Kidney Diseases / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D008297:Male; D011188:Potassium / Q000378:metabolism; D012079:Renal Circulation; D012964:Sodium / Q000378:metabolism; D014867:Water / Q000378:metabolism
D000910:Antibodies, Heterophile; D014867:Water; D012964:Sodium; D011188:Potassium