Meningococcal disease in congenital absence of the fifth component of complement.
We describe a family in which 2 brothers had meningococcal infection, 1 of them twice. Their parents were first degree cousins. The brothers showed a complete, isolated deficiency of C5, both antigenic and functional. The parents had half-normal values, and the data are compatible with an inherited C5 deficiency where the defect is transmitted as an autosomal codominant trait.
Nielsen
H E
HE
Department of Infectious Diseases M, Rigshospitalet, Copenhagen, Denmark.
Koch
C
C
D000328:Adult; D003182:Complement C5 / Q000172:deficiency* / Q000235:genetics; D003170:Complement Pathway, Alternative; D003171:Complement Pathway, Classical; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D008585:Meningitis, Meningococcal / Q000235:genetics* / Q000276:immunology; D010375:Pedigree
D003182:Complement C5