Concentrations of flucloxacillin in heart valves and subcutaneous and muscle tissues of patients undergoing open-heart surgery.
Thirty-seven patients were given a single, 2-g intravenous bolus injection of flucloxacillin prior to open-heart surgery. Within 12 h, flucloxacillin concentrations in serum and heart valves declined from 125.2 to 4.4 micrograms/ml and from 16.5 to 3.7 micrograms/g, respectively. Concentrations in subcutaneous tissue and muscle were almost identical, declining from 14.7 or 14.2 micrograms/g to undetectable levels after 8 to 10 h.
Department of Hospital Epidemiology, University Hospital, Freiburg, Federal Republic of Germany.
U
U
Frank
E
E
Schmidt-Eisenlohr
V
V
Schlosser
G
G
Spillner
M
M
Schindler
F D
FD
Daschner
D006348:Cardiac Surgical Procedures; D003023:Cloxacillin / Q000031:analogs & derivatives*; D005260:Female; D005436:Floxacillin / Q000378:metabolism* / Q000493:pharmacokinetics; D006351:Heart Valves / Q000378:metabolism*; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*
D005436:Floxacillin; D003023:Cloxacillin