Intra-hepato-arterial chemotherapy with CDDP and 5-FU for metastases to the liver from colorectal and gastric cancers.
Thirty-five patients with metastases to the liver from colorectal (26 patients) and gastric (nine patients) cancers were treated with intra-hepato-arterial (IHA) injections of cis-diamminedichloroplatinum (II) (CDDP) plus 5-fluorouracil (5-FU). Therapeutic schedules consisted of manual bolus injections of CDDP. (25-35 mg/m2/week) and 5-FU (150-180 mg/m2/day) Regimen I, and CDDP (25-35 mg/m2/10-14 days) and 5-FU (60-70 mg/m2/day Regimen II. In patients with colorectal cancer metastatic to the liver, partial response (PR) rates in Regimens I and II were 38% and 62%, respectively. By contrast, in patients with metastases to the liver from gastric cancer, a PR was obtained in only one of nine patients (11%). IHA chemotherapy CDDP plus 5-FU, especially following Regimen II, appears to be a strongly recommendable strategy for treatment of metastatic liver tumors derived from colorectal cancer.
1st Department of Surgery, Tottori University School of Medicine, Yonago, Japan.
M
M
Maeta
S
S
Koga
N
N
Shimizu
R
R
Hamazoe
A
A
Murakami
M
M
Ishiguro
T
T
Sawada
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003110:Colonic Neoplasms / Q000601:surgery*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000601:surgery*; D013274:Stomach Neoplasms / Q000601:surgery*
D002945:Cisplatin; D005472:Fluorouracil