Inhibition of human tumor cell induced platelet aggregation by antibodies to platelet glycoproteins Ib and IIb/IIIa.
Tumor cell induced platelet aggregation was shown to be inhibited in a dose dependent manner by preincubation of human platelets with antibodies to platelet glycoprotein Ib and the IIb/IIIa complex. Combination of antibody to Ib and antibody to the IIb/IIIa complex at concentrations which produced half maximal inhibition of platelet aggregation alone caused complete inhibition of tumor cell induced platelet aggregation. Antibodies to platelet glycoproteins Ib and the IIb/IIIa complex also inhibited platelet synthesis of thromboxane A2, but not synthesis of 12-hydroxyeicosatrienoic acid. Inhibition of tumor cell induced platelet aggregation with antibodies against platelet glycoproteins suggests a role for these glycoproteins in tumor cell-platelet interactions and possibly platelet facilitated tumor cell metastasis.
Department of Radiation Oncology, Wayne State University, Detroit, MI.
I M
IM
Grossi
L A
LA
Fitzgerald
A
A
Kendall
J D
JD
Taylor
B F
BF
Sloane
K V
KV
Honn
D000906:Antibodies / Q000276:immunology*; D002460:Cell Line; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010980:Platelet Membrane Glycoproteins / Q000276:immunology / Q000502:physiology*
D000906:Antibodies; D010980:Platelet Membrane Glycoproteins