[Isotypes of rheumatoid factors and cellular immunity anomalies in rheumatoid polyarthritis. Apropos of 61 cases].
In 61 patients with rheumatoid polyarthritis, we studied the rheumatoid factors isotypes, class IgM, IgG, IgA and the abnormalities of the ratio CD4/CD8 (lymphocytes with membrane phenotype "helper"/lymphocytes with membrane phenotype "suppressor") determined by monoclonal antibodies. We found a statistically significant increase of the rate of IgM rheumatoid factors (p less than 0.0001), IgG (p less than 0.004), IgA (p less than 0.008), in patients with rheumatoid polyarthritis whose ratio exceeded that of the control population. On the other hand, the percentage of rheumatoid factors detected by agglutination was not significantly increased in this group. This increase seemed linked to a specific abnormality of the control of lymphocytes B which synthesize rheumatoid factors.
Service de Rhumatologie, Hôpital Trousseau, Tours.
B
B
Fouquet
C
C
Gauthier
M
M
Renoux
M C
MC
Eveleigh
J P
JP
Valat
P
P
Bardos
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D008214:Lymphocytes / Q000145:classification*; D008297:Male; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000032:analysis* / Q000145:classification
D007136:Immunoglobulins; D012217:Rheumatoid Factor
Isotypes des facteurs rhumatoïdes et anomalies de l'immunité cellulaire dans la polyarthrite rhumatoïde. A propos de 61 cas.