[Changes in the form and cytoskeleton of cultured fibroblasts as affected by 12-tetradecanoylphorbol-13-acetate].
A new type of reorganization of cytoskeleton induced by 12-o-tetradecanoyl-phorbol-13-acetate motility: division of the cell into an actin-rich active part and stable processes with numerous microtubules. Such a phenomenon was observed under a short-term influence of TPA on different lines of cultured fibroblasts: NRK, Balb/C 3T3, C-103, C-84, CAK-7. The effect of TPA was reversible and suppressed by cytochalasin B and colcemid. TPA is supposed to induce changes in the interaction between actin cortex and microtubule system.
V B
VB
Dugina
T M
TM
Svitkina
Iu M
IuM
Vasil'ev
I M
IM
Gel'fand
D008841:Actin Cytoskeleton / Q000187:drug effects / Q000648:ultrastructure; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D003571:Cytochalasin B / Q000494:pharmacology; D003599:Cytoskeleton / Q000187:drug effects* / Q000648:ultrastructure; D003703:Demecolcine / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects* / Q000648:ultrastructure; D007382:Intermediate Filaments / Q000187:drug effects / Q000648:ultrastructure; D051379:Mice; D008870:Microtubules / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013997:Time Factors
D003571:Cytochalasin B; D013755:Tetradecanoylphorbol Acetate; D003703:Demecolcine
Izmenenie formy i tsitoskeletona kul'tiviruemykh fibroblastov pod vliianiem 12-tetradekanoilforbol-13-atsetata.