New cytotoxic aristolactams from Pararistolochia flos-avis.
Two new aristolactams, aristolactam-FI [1] and -FII [2], were isolated from active extracts of Pararistolochia flos-avis. Their structures were elucidated on the basis of nmr, ms, uv, and ir spectral data. Aristolactam-I [3] and -AII [4] were also isolated from this plant. Aristolactam-AII showed cytotoxicity against PS and KB cells in culture.
Sun
N J
NJ
Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
Antoun
M
M
Chang
C J
CJ
Cassady
J M
JM
D000107:Acetylation; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis* / Q000494:pharmacology; D034341:Aristolochic Acids; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D007769:Lactams / Q000032:analysis*; D010616:Phenanthrenes / Q000032:analysis*; D010946:Plants, Medicinal / Q000032:analysis*
D000972:Antineoplastic Agents, Phytogenic; D034341:Aristolochic Acids; D007769:Lactams; D010616:Phenanthrenes; C000228:aristolochic acid I