Characterization of a new tumor associated antigen from mammary carcinoma cells by monoclonal antibodies.
A new tumor associated glycoprotein antigen was identified in the soluble fraction of adenocarcinoma of the mammary gland. Immunoprecipitation with a monoclonal antibody revealed an antigen with a molecular weight of 300.000 daltons and a pI of 4.3. Immunoblotting of sera from patients with mammary carcinoma indicated the presence of the antigen at various concentrations. This antigen was not detected in any of the normal sera tested so far and was absent on non-malignant breast tissue.
Biotec Diagnostica International GmbH, Hannover.
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Czuppon
D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology; D000911:Antibodies, Monoclonal / Q000302:isolation & purification; D000936:Antigen-Antibody Complex / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology; D002851:Chromatography, High Pressure Liquid; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D009369:Neoplasms / Q000097:blood
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor