[Synthesis and properties of acyclic analogs of ribavirin].
Acyclic analogues of ribavirine, viz. 1-(1-hydroxy-4-oxahex-3-yl)-, 1-(1-chloro-4-oxahex-3-yl)-, 1-(1,2-dihydroxy-4-oxahex-3-yl)-, 1-(1,6-dihydroxy-4-oxahex-3-yl)-, 1-(1-chloro-6-hydroxy-4-oxahex-3-yl)-, and 1-(1,2,6-trihydroxy-4-oxahex-3-yl)-1,2,4-triazole-3-carboxamide, with the C3'-C4' bond of the furanose ring cleaved, have been prepared by condensation of trimethylsilyl derivatives of 3-ethoxycarbonyl-1,2,4-triazole with alkylating agents in the presence of SnCl4 followed by treatment with methanolic ammonia. Convenient methods for synthesis of the alkylating agents were elaborated.
Tsilevich
T L
TL
Kochetkova
S V
SV
Shchaveleva
I L
IL
Smirnov
I P
IP
Gottikh
B P
BP
D055598:Chemical Phenomena; D002621:Chemistry; D012254:Ribavirin / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D012263:Ribonucleosides / Q000138:chemical synthesis*
D012263:Ribonucleosides; D012254:Ribavirin
Sintez i svoĭstva atsiklicheskikh analogov ribavirina.