Effects of compound IS-35 on intraocular pressure.
The influence of compound IS-35 on intraocular pressure of unanesthetized rabbits was studied. In some cases intraocular pressure was measured with either the tonometer of Schiotz and was calculated in mmHg according to Leydhecker's scale (1973), or with the tonometer of Maclakov. Intraocular pressure was measured before and at 30, 60, 120, 180, 240 and 360 min after topical application of IS-35, timolol and trimetoquinol. It was established that IS-35 applied locally in the eye as 0.5% solution or collyrium decreases statistically significantly intraocular pressure. This effect was similar to that of timolol and exceeded significantly the effect of trimetoquinol. The experimental study on the beta-adrenergic adenylate cyclase showed that the mechanism of action of IS-35 on ophthalmotonus most probably is similar to the effect of timolol and is due to the suppression of aqueous humor formation.
Markov
M
M
Sci. Institute of Pharmacology and Pharmacy, Medical Academy, Sofia, Bulgaria.
Ivanov
C
C
Uzunov
P
P
Ovcharov
R
R
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001600:Berberine Alkaloids / Q000494:pharmacology*; D005260:Female; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013999:Timolol / Q000494:pharmacology; D014065:Tonometry, Ocular; D014213:Tretoquinol / Q000494:pharmacology
D001600:Berberine Alkaloids; D013999:Timolol; C057085:IS 35; D014213:Tretoquinol