BMY-28438 (3,7-dihydroxytropolone), a new antitumor antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity.
A new antitumor antibiotic BMY-28438 was isolated from the cultured broth of Streptomyces tropolofaciens No. K611-97. The antibiotic showed potent cytotoxicity against cultured B16 melanoma cells and remarkable prolongation of life span of mice bearing B16 melanoma. The structure of BMY-28438 was determined as 3,7-dihydroxytropolone on the basis of spectral analyses and direct comparison with the authentic compound synthesized.
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
K
K
Sugawara
M
M
Ohbayashi
K
K
Shimizu
M
M
Hatori
H
H
Kamei
M
M
Konishi
T
T
Oki
H
H
Kawaguchi
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D013302:Streptomyces / Q000378:metabolism*; D014334:Tropolone / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D014334:Tropolone; C057099:3,7-dihydroxytropolone