[Effect of weightlessness on the indices of brain development (the results of pregnant rats being on the Kosmos-1514 biosatellite and research on the subsequent development of their progeny on Earth)].
Beginning from the 13th day of pregnancy the rats were under conditions of weightlessness of spaceflight for 6 days. After landing in 18-day-old fetuses the state of their brain development is investigated comparing to that in control animals, that are on the Earth. As demonstrates analysis of a number of morphological processes: reproduction, migration, neuronal differentiation, growth of processes, establishment of nervous connections, neuroglial interconnections and vascularization--all they under conditions of weightlessness develop rather fully. Certain deviations in vascularization (as examples the medulla oblongata and the striated tuber are taken) are observed--the amount of vessels is greater and they are thinner--and changes in migration rate of cells is demonstrated by the example of the cortical plate formation. These changes are quickly levelled during their subsequent development on the Earth.
Olenev
S N
SN
Danilov
A R
AR
Kriuchkova
T A
TA
Sorokina
L M
LM
Krasnov
I B
IB
D000818:Animals; D001921:Brain / Q000196:embryology* / Q000201:enzymology; D005260:Female; D005865:Gestational Age; D006651:Histocytochemistry; D011247:Pregnancy; D051381:Rats; D013026:Space Flight; D014586:USSR; D014893:Weightlessness / Q000009:adverse effects*
Vliianie nevesomosti na nekotorye pokazateli razvitiia golovnogo mozga (rezul'taty prebyvaniia beremennykh krys na biosputnike "Kosmos-1514" i issledovanie posleduiushchego razvitiia ikh potomstva na Zemle).