Dopamine-2 receptor blockade does not affect the ocular hypotensive action of timolol.
We have shown that metoclopramide, a dopamine-2 antagonist, failed to antagonise the ocular hypotensive action of timolol. The practical implication of combining dopamine agonists with beta-adrenoceptor antagonists in the treatment of glaucoma is discussed.
Department of Clinical Pharmacology, St Bartholomew's Hospital Medical College, London.
Q A
QA
Mekki
P
P
Turner
D000328:Adult; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D011954:Receptors, Dopamine / Q000187:drug effects*; D013997:Time Factors; D013999:Timolol / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D011954:Receptors, Dopamine; D013999:Timolol; D008787:Metoclopramide