Biosynthesis of napyradiomycins.
Biosynthetic studies on napyradiomycins were carried out based on the incorporation of [2-13C]acetate and [1,2-13C]acetate. The alignment of acetate units suggested that the B and C rings of napyradiomycins are derived from a pentaketide, while ring A and the side chain may be synthesized from mevalonate.
Shiomi
K
K
Institute of Microbial Chemistry, Tokyo, Japan.
Iinuma
H
H
Naganawa
H
H
Isshiki
K
K
Takeuchi
T
T
Umezawa
H
H
D000085:Acetates / Q000378:metabolism; D000192:Actinomycetales / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D009682:Magnetic Resonance Spectroscopy; D008798:Mevalonic Acid / Q000378:metabolism; D009285:Naphthoquinones / Q000096:biosynthesis
D000085:Acetates; D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; C054850:napyradiomycin C2; C054849:napyradiomycin C1; C054848:napyradiomycin B1; C054847:napyradiomycin A1; C054262:napyradiomycin A2; D008798:Mevalonic Acid