Effect of anticholinergic preanesthetic medicaments on the requirements of halothane for anesthesia in the cat.
To study the effects of anticholinergics on anesthetic requirements, minimal alveolar concentrations (MAC) for halothane in the cat were measured before and after IM administration of an anticholinergic (atropine sulfate [0.045 mg/kg], glycopyrrolate [0.011 mg/kg], or scopolamine hydrobromide [0.02 mg/kg]) or a physiologic saline control. The study was performed in 8 adult cats, using a randomized-block experimental design. There was no significant difference between the mean MAC obtained before and after administration of any of the test drugs or vs the control values. The mean MAC of halothane in cats was 0.985% atmosphere.
Department of Medical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
A I
AI
Webb
R M
RM
McMurphy
D000769:Anesthesia, Inhalation / Q000662:veterinary*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002415:Cats / Q000502:physiology*; D005260:Female; D006024:Glycopyrrolate / Q000494:pharmacology; D006221:Halothane; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D011229:Preanesthetic Medication / Q000662:veterinary*; D012601:Scopolamine / Q000494:pharmacology
D010276:Parasympatholytics; D001285:Atropine; D012601:Scopolamine; D006221:Halothane; D006024:Glycopyrrolate