Protein comparison and classification: a differential geometric approach.
A method is proposed for rapidly, quantitatively comparing protein structures of arbitrary sizes, based on the differential geometric representation. The method is applied to a group of 22 protein x-ray structures, and the resulting network of closest relationships is delineated. Several well-known fold types are automatically detected as groupings of related structures, even when the constituent proteins are of different lengths. A complete gradation of types is shown to be detected, ranging from all-helical to all-beta-structure proteins. A relationship among functionally similar proteins is shown in several cases, even where their three-dimensional structures differ. It is suggested that the positions of proteins within the network of relationships correspond with their folding mechanisms.
Department of Biophysics, University of Rochester, School of Medicine and Dentistry, NY 14642.
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S
Rackovsky
D A
DA
Goldstein
D011487:Protein Conformation; D011506:Proteins / Q000145:classification*
D011506:Proteins