Metabolism-independent cerebral vasodilation elicited by electrical stimulation of the centromedian-parafascicular complex in rat.
Changes in local cerebral blood flow (1CBF) and local cerebral glucose utilization (1CGU) during electrical stimulation of the centromedian-parafascicular complex in rat have been determined using the autoradiographic [14C]iodoantipyrine and 2-deoxy-[14C]glucose methods. In 40 out of 47 cerebral regions measured, the centromedian-parafascicular complex (CM-Pf) stimulation elicited an increase in 1CBF. The increase in 1CBF was not associated with a rise in cerebral metabolism in 38 regions. Thus, it appears that the activation of CM-Pf neurons or fibers passing through it could play an important role in regulating primary cerebral vasodilation.
Laboratoire de Physiologie et Physiopathologie Cérébrovasculaire, INSERM U. 182, C.N.R.S. U.A. 641, Université Paris VII, France.
S
S
Mraovitch
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J
Seylaz
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives / Q000032:analysis; D001345:Autoradiography; D001921:Brain / Q000098:blood supply* / Q000378:metabolism / Q000502:physiology; D002560:Cerebrovascular Circulation; D003847:Deoxyglucose / Q000032:analysis; D004558:Electric Stimulation; D005947:Glucose / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013787:Thalamic Nuclei / Q000502:physiology*; D014664:Vasodilation
D003847:Deoxyglucose; D005947:Glucose; D000983:Antipyrine; C008135:iodoantipyrine