[Hemodynamic reactions in response to the intracerebral administration of angiotensin II to alert normotensive and hypertensive rats].
Systemic and regional hemodynamic effects of angiotensin II (Ang II) intracerebroventricular injection in alert spontaneously hypertensive (SHR) and normotensive Wistar rats were studied with microsphere technique. Ang II administration produced equal increase in blood pressure (+19.6 and +20.4 mm Hg) and opposite changes in cardiac output (the 14% rise and the 21% drop, resp.) in Wistar and SHR. Blood flow decreased in most organs except heart and adrenal glands in SHR. Vascular resistance tended to fall in kidneys in Wistar and increased by 82% in SHR, which might have a pathogenetic significance for maintenance of hypertension.
O S
OS
Medvedev
A
A
Khak
D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D006439:Hemodynamics / Q000187:drug effects*; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D012016:Reference Values
D000804:Angiotensin II
Reaktsii gemodinamiki v otvet na vnutrimozgovoe vvedenie angiotenzina II bodrstvuiushchim normotenzivnym i gipertenzivym krysam.