The effect of induced liver, kidney and lung lesions on the toxicity of levamisole and diazinon in calves.
Liver damage in calves, produced by the oral administration of the flukecide, carbon tetrachloride, increased the toxic effect of diazinon but not of levamisole, whereas the presence of a renal tubular lesion caused by mercuric chloride enhanced the toxicity of both commonly used anthelmintic compounds. The toxicity of diazinon was increased in calves with a lung lesion caused by oral dosing with tryptophan, an agent implicated in 'fog fever' of cattle.
University of Liverpool, Department of Veterinary Clinical Science, Leahurst, Neston, South Wirral, U.K.
E B
EB
Abdelsalam
E J
EJ
Ford
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology; D002417:Cattle; D056486:Chemical and Drug Induced Liver Injury; D002802:Cholinesterases / Q000097:blood; D003976:Diazinon / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D007674:Kidney Diseases / Q000139:chemically induced / Q000503:physiopathology*; D007978:Levamisole / Q000633:toxicity*; D008107:Liver Diseases / Q000503:physiopathology*; D008171:Lung Diseases / Q000139:chemically induced / Q000503:physiopathology*; D008627:Mercuric Chloride; D014364:Tryptophan
D007306:Insecticides; D007978:Levamisole; D008627:Mercuric Chloride; D014364:Tryptophan; D002802:Cholinesterases; D003976:Diazinon