Fibronectin decrease in liver cirrhosis is related to spleen size.
We found a significantly lower plasma fibronectin concentration in cirrhotic patients than in controls, a significant inverse relationship between fibronectin and spleen size, but no correlation between fibronectin and hepatic blood flow, prothrombin time, or serum albumin. We suggest that the increased degradation in the enlarged spleen is more relevant than the decreased synthesis in reducing plasma fibronectin levels during liver cirrhosis with portal hypertension.
Centro Immuno-Transfusionale, Ospedale di Pordenone, Pordenone, Italia.
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D000328:Adult; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D008102:Liver Circulation; D008103:Liver Cirrhosis / Q000097:blood*; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D013163:Splenomegaly / Q000097:blood*
D005353:Fibronectins