Enantiomeric cannabinoids: stereospecificity of psychotropic activity.
The 1,1-dimethylheptyl homolog of (-)-(3R,4R)-7-hydroxy-delta-6- tetrahydrocannabinol (compound II) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II).
Mechoulam
R
R
Brettler Medical Research Center, Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Feigenbaum
J J
JJ
Lander
N
N
Segal
M
M
Järbe
T U
TU
Hiltunen
A J
AJ
Consroe
P
P
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002186:Cannabinoids / Q000138:chemical synthesis / Q000494:pharmacology; D010856:Columbidae; D004305:Dose-Response Relationship, Drug; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D002186:Cannabinoids