Effect of heavy weekend drinking on urinary dolichol levels.
The effect of acute heavy alcohol consumption on urinary dolichol levels was studied in 10 healthy volunteers during 2 separate weekends (48 hr). During one of the weekends the subjects received alcohol 5.5 g of per kg body weight in 4 different sessions. The other weekend was otherwise identical, but no alcohol was served. During the weekend when the subjects consumed alcohol, urinary dolichol levels began to rise significantly on the second day of the experiment reaching more than double of the baseline values 42 hours after the beginning of the experiment. During the control weekend, no such increase in urinary dolichol levels was observed. Thus, heavy drinking lasting more than one day is capable of increasing urinary dolichol levels.
Research Unit of Alcohol Diseases, Helsinki University Central Hospital, Finland.
R P
RP
Roine
R
R
Ylikahri
P
P
Koskinen
A
A
Suokas
J
J
Hämäläinen
M
M
Salaspuro
D000328:Adult; D000428:Alcohol Drinking / Q000502:physiology*; D004224:Diterpenes / Q000652:urine*; D004286:Dolichols / Q000652:urine*; D000431:Ethanol / Q000008:administration & dosage; D006801:Humans; D008297:Male; D013997:Time Factors
D004224:Diterpenes; D004286:Dolichols; D000431:Ethanol