Prenatal diagnosis of partial trisomy 22 derived from a maternal t(11; 22) (q23; q11).
A fetus with partial trisomy 22 was detected by amniocentesis in a pregnant woman with balanced translocation, 46, XX, t(11; 22) (q23; q11). The aborted fetus had multiple congenital anomalies consisting of microcephaly, cleft lip and palate. The extra acrocentric chromosome was identified as der (22), t(11; 22) (q23; q11). The aborted fetus is compared with other trisomic cases described in literatures, and perinatal diagnosis of this case was discussed.
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai.
S
S
Sou
T
T
Takabayashi
H
H
Sasaki
K
K
Sasamoto
Y
Y
Shintaku
Z J
ZJ
Li
N
N
Ozawa
A
A
Yajima
D000328:Adult; D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014178:Translocation, Genetic; D014314:Trisomy