[Reproductive pharmacology of prostaglandins].
Effects of prostaglandins and their analogues in reproduction were investigated using rats and Japanese monkeys. Prostaglandin of the F series exerted uterine contractile, luteolytic, anti-nidation and abortifacient effects. Prostaglandins of the E series exhibited a potent uterine contractile effect, although their luteolytic, anti-nidation and abortifacient effects were much less potent than those of the PGF series. A comparison of animal and human data on prostaglandins and their analogues indicated a good cor-relationship between the uterine contractile effect in animals (rates and monkeys) and the abortifacient or labor inducing effect in humans.
Department of Physiology, Kyoto University, Aichi.
K
K
Oshima
K
K
Matsumoto
A
A
Akimoto
T
T
Tsuda
M
M
Sasada
D000019:Abortifacient Agents / Q000494:pharmacology*; D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D006801:Humans; D007751:Labor, Induced; D008186:Luteolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008251:Macaca; D011247:Pregnancy; D011453:Prostaglandins / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects*; D014590:Uterine Contraction / Q000187:drug effects*
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D008186:Luteolytic Agents; D011453:Prostaglandins