[Effect of adamantyl quaternary ammonium derivatives on the autonomic ganglia].
The ganglionic blocking activity of mono- and bis-quaternary ammonium compounds with adamantyl radicals was studied on unanesthetized mice my measuring the pupil diameter with a binocular lens. To measure the mydriatic action of the agents, experiments were performed on anesthetized cats with recording of nictiating membrane contractions under the stimulation of the cervical sympathetic trunk. It was established that the ganglionic blocking activity of mono-quaternary compounds depends on the position of the adamantyl radical in the molecule. The maximal ganglionic blocking activity was formed in ethyl-n-toluenesulphonate of beta-diethylaminoethyl ether of I-adamantyl acetic acid and in N-adamantyl analogue of tetramethylammonium. Introduction of the adamantyl radical into the cation centres of symmetrical polymethylene bis-trimethylammonium compounds (with the length of interinonic chain of 5-10 carbon atoms) leads to the loss of the ganglionic blocking activity.
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Buianov
D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005725:Ganglia, Autonomic / Q000187:drug effects*; D008297:Male; D051379:Mice; D009184:Mydriatics / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D009184:Mydriatics; D000644:Quaternary Ammonium Compounds; D000218:Adamantane
O vliianii adamantil'nykh chetvertichnykh ammonievykh proizvodnykh na vegetativnye ganglii.