The metabolism of EGYT-475, a new antidepressant agent, in rats.
The metabolites of EGYT-475 excreted by the kidney were studied in rats using radioactive analogues of the compound tested. 40% of the total radioactivity was found in rat urine which was collected over 48 h, pooled, centrifuged, membrane-filtered, and from which the metabolites were separated by combined chromatographic procedures or extracted after acidic hydrolysis. Gas chromatographic and GC/MS studies showed that 31.1% of the radioactivity found in urine proved to be picolinyl-piperazine, 3.7% was N-benzyl-piperazine and 28.5% of it was picolinic acid. Hippuric acid accounted for 53.2% of the radioactivity of the acid hydrolyzed urine.
Department of Pharmacodynamics, Semmelweis University of Medicine, Budapest, Hungary.
A
A
Guttmann
J
J
Nagy
K
K
Magyar
D000818:Animals; D000928:Antidepressive Agents / Q000378:metabolism* / Q000652:urine; D002849:Chromatography, Gas; D008297:Male; D013058:Mass Spectrometry; D010879:Piperazines / Q000378:metabolism* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
D000928:Antidepressive Agents; D010879:Piperazines; C040401:EGYT 475