Propranolol steady-state pharmacokinetics are unaltered by omeprazole.
In a randomised double-blind cross-over study, 8 normal subjects received propranolol 80 mg twice daily with omeprazole 20 mg or identical placebo each morning. Propranolol kinetics were measured on day 8 of both treatment periods. Areas under the propranolol concentration/time curves were not significantly increased by omeprazole treatment: off treatment mean 787.6, on treatment 802.5 ng-1.ml.h. Maximum and minimum steady-state propranolol concentrations were similarily unaffected. Omeprazole also failed to increase the clinical effect of propranolol, as assessed by exercise tests on Day 8 of treatment. We conclude that omeprazole in the dose likely to be used for peptic ulcer has no significant effect on the kinetics or action of propranolol.
Henry
D
D
Discipline of Clinical Pharmacology, Faculty of Medicine, Royal Newcastle Hospital, Australia.
Brent
P
P
Whyte
I
I
Mihaly
G
G
Devenish-Meares
S
S
D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D005080:Exercise Test; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000494:pharmacology*; D011433:Propranolol / Q000493:pharmacokinetics*
D011433:Propranolol; D009853:Omeprazole