Species differences in the intestinal excretion of emepronium.
A substantial proportion of a parenteral dose of emepronium given to dogs is excreted via the gastrointestinal tract by biliary excretion and by excretion through the intestinal mucosa (Hallén et al. 1979). In the present paper the different routes of elimination were further investigated in mouse and man and compared to the dog. The disposition of emepronium-derived radioactivity (14C) in the three species showed that about 45% was excreted via urine and 55% via faeces. The proportion of the faecal excretion of 14C that could be referred to the intestinal route differed between the species and was about 20% in man, 60% in the mouse and most pronounced, 80%, in the dog.
Department of Pharmacology, R & D, KabiVitrum AB, Stockholm, Sweden.
B
B
Hallén
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L
Räf
D000368:Aged; D000818:Animals; D001646:Bile / Q000378:metabolism; D004629:Emepronium / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D005704:Gallbladder / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects; D008297:Male; D051379:Mice; D011708:Pylorus / Q000502:physiology; D000644:Quaternary Ammonium Compounds / Q000378:metabolism*; D013045:Species Specificity
D000644:Quaternary Ammonium Compounds; D004629:Emepronium