111In-labelled baboon platelets: the influence of in vivo redistribution and contaminating 114mIn on the radiation dose.
In five normal baboons, whole body 111In decreased slowly (t1/2 = 60 days) after the end of platelet lifespan. There was slight elution of radioactivity from the liver and spleen, the important sites of platelet sequestration. A fraction of this eluted radioactivity accumulated in the bone marrow, but also in other tissues. This redistribution did not have a significant effect on the measurement of in vivo platelet kinetics. It did however, diminish the total weighted radiation dose, especially that due to contaminating 114mIn.
Kotzé
H F
HF
Blood Platelet Research Unit, South African Medical Research Council, Bloemfontein.
Lötter
M G
MG
Heyns
A D
AD
Sweetlove
A
A
Badenhorst
P N
PN
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism; D004307:Dose-Response Relationship, Radiation; D007204:Indium / Q000097:blood / Q000493:pharmacokinetics*; D007205:Indium Radioisotopes; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D010215:Papio / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
D007205:Indium Radioisotopes; D007204:Indium