Muscle pathology in the neuroleptic malignant syndrome.
In a fatal case of neuroleptic malignant syndrome, a muscle sample taken within 1 h of death showed acute myopathic features with absence of muscle glycogen and neutral lipid. These features suggest that hyperpyrexia in this syndrome may be caused by heat production from uncoupled phosphorylation in muscle and imply that the primary biochemical abnormality responsible for this uncontrolled heat production might be muscular rather than hypothalamic.
Martin
D T
DT
Department of Neurology, Newham General Hospital, London England.
Swash
M
M
D000328:Adult; D005476:Fluphenazine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009132:Muscles / Q000473:pathology*; D009459:Neuroleptic Malignant Syndrome / Q000473:pathology*; D011352:Procyclidine / Q000009:adverse effects / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000188:drug therapy
D011352:Procyclidine; C011825:fluphenazine depot; D005476:Fluphenazine