Reversal of progressive necrotizing vasculitis with intravenous pulse cyclophosphamide and methylprednisolone.
We describe a patient with polyarteritis nodosa who, despite therapy with daily doses of oral prednisone and cyclophosphamide, developed acute renal failure. Renal histopathologic examination demonstrated crescentic glomerulonephritis. Treatment with intravenous pulse cyclophosphamide and methylprednisolone resulted in clinical improvement and significant recovery of renal function.
Fort
J G
JG
Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Abruzzo
J L
JL
D000328:Adult; D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005921:Glomerulonephritis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D009336:Necrosis; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
D003520:Cyclophosphamide; D008775:Methylprednisolone