Hyperprolactinaemia increases intraocular pressure in humans.
Nine female and 2 male hyperprolactinaemic patients (plasma prolactin levels averaging 180-420 ng/ml) were subjected to measurements of intraocular pressure (IOP) either under basal conditions or after water load in comparison with 5 healthy volunteers. Basal values of IOP in hyperprolactinaemic patients were 37.8% higher than those of controls. Moreover, after water load hyperprolactinaemic patients showed a sustained increase in IOP that reached values of pathological significance. These results suggest that prolactin may contribute to the hormonal regulation of IOP in humans.
Institute of Pharmacology, Faculty of Medicine, Catania, Italy.
F
F
Drago
N
N
Cavallaro
A
A
Dal Bello
S
S
Cavaliere
D
D
Spampinato
G
G
Gorgone
D000236:Adenoma / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D002924:Ciliary Body / Q000503:physiopathology; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000503:physiopathology*; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000503:physiopathology; D011388:Prolactin / Q000502:physiology; D011981:Receptors, Prolactin / Q000502:physiology
D011981:Receptors, Prolactin; D011388:Prolactin