The role of plasmids in opsonin-independent Staphylococcus aureus-leukocyte interactions.
The opsonin-independent phagocytic and bactericidal activity of human polymorphonuclear leukocytes stimulated by two Staphylococcus aureus strains and their variants with differing plasmid patterns was investigated. Interactions between staphylococci and phagocytes were evaluated by chemiluminescence and intracellular killing tests. The results obtained indicate that the presence or absence of certain plasmids can modify staphylococcal phagocytosis and their susceptibility to intracellular killing. Pretreatment of the strains investigated with subinhibitory concentrations of mezlocillin and ofloxacin (10% MIC) influenced these parameters, too.
Department of Immunology, National Tuberculosis Research Institute, Warsaw, Poland.
P
P
Garliński
G
G
Młynarczyk
W
W
Roszkowski
G
G
Pulverer
J
J
Jeljaszewicz
D006801:Humans; D008163:Luminescent Measurements; D009504:Neutrophils / Q000276:immunology*; D009895:Opsonin Proteins; D010587:Phagocytosis; D010957:Plasmids; D013211:Staphylococcus aureus / Q000235:genetics / Q000276:immunology*
D009895:Opsonin Proteins