dl-alpha-Tocopheryl acetate induces hypocoagulability and platelet hypoaggregability in rats.
Rats receiving daily IP injections of dl-alpha-tocopheryl acetate (50 mg/kg) for 4 days showed levels of plasma alpha-tocopherol slightly increased and normal platelet count but platelet aggregation (induced by ADP or adrenaline) was significantly decreased when compared with the control animals. In addition, both platelet-rich plasma and platelet-poor plasma-thromboelastograms from treated rats showed thromboplastine-formation times significantly higher than those from control animals. Serum biochemical parameters showed several minor modifications in treated rats with respect the control ones. It suggests that vitamin E could be considered as a possible useful tool for the therapy of several hyperaggregable or hypercoagulable states.
Physiology and Pharmacology Department, Alcalá de Henares University, Spain.
M L
ML
Díez Marques
F J
FJ
Lucio Cazaña
M
M
Rodringuez Puyol
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001798:Blood Proteins / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D004837:Epinephrine / Q000494:pharmacology; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D001798:Blood Proteins; D010975:Platelet Aggregation Inhibitors; D014810:Vitamin E; D000244:Adenosine Diphosphate; D003404:Creatinine; D000469:Alkaline Phosphatase; D024502:alpha-Tocopherol; D024505:Tocopherols; D004837:Epinephrine