Experimental evidence that tryptamine alkaloids do not cause Phalaris aquatica sudden death syndrome in sheep.
The acute toxicity for sheep of 3 alkaloids that occur in Phalaris acquatica was examined by intravenous and oral administration. The lowest tested dose rates that produced clinically observed signs were, for 5-methoxy dimethyltryptamine, 0.1 mg/kg body weight intravenously and 40 mg/kg orally; for gramine, 10 mg/kg intravenously and 500 mg/kg orally; and for hordenine, 20 mg/kg intravenously and 800 mg/kg orally. All induced the clinical signs observed in the nervous form of phalaris toxicity, but none induced the cardiac, sudden death, syndrome.
Bourke
C A
CA
New South Wales Department of Agriculture, Agricultural Research and Veterinary Centre, Orange.
Carrigan
M J
MJ
Dixon
R J
RJ
D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D003645:Death, Sudden / Q000139:chemically induced / Q000662:veterinary*; D005260:Female; D026121:Indole Alkaloids; D008297:Male; D008732:Methoxydimethyltryptamines / Q000633:toxicity*; D010939:Plant Poisoning / Q000662:veterinary; D006109:Poaceae; D012701:Serotonin / Q000031:analogs & derivatives*; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced*; D013577:Syndrome / Q000662:veterinary; D014439:Tyramine / Q000031:analogs & derivatives
D000470:Alkaloids; D026121:Indole Alkaloids; D008732:Methoxydimethyltryptamines; D012701:Serotonin; C007884:gramine; C007964:hordenine; D014439:Tyramine