Lack of effect of antacids on plasma concentrations of omeprazole given as enteric-coated granules.
Twelve male volunteers were studied after a single oral dose of 20 mg omeprazole given as enteric-coated granules with and without concomitant administration of 10 ml of a potent liquid antacid (buffering capacity 56.6 mmol 10 ml-1) under fasting conditions. No statistically significant differences were detected in median Cmax (0.41 approximately equal to 0.53 mumol l-1), the geometric mean AUC (0.80 approximately equal to 0.81 mumol l-1 h) or median tmax (1.25 h), with and without antacid.
Department of Gastroenterology, Free University Hospital, Amsterdam, The Netherlands.
H A
HA
Tuynman
H P
HP
Festen
K
K
Röhss
S G
SG
Meuwissen
D000328:Adult; D000863:Antacids / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage / Q000097:blood*
D000863:Antacids; D003692:Delayed-Action Preparations; D009853:Omeprazole