Chelation in metal intoxication. XXVIII: Effect of thiochelators on mercury (II) toxicity: pre- and post treatment.
The effect of treatment with alpha-mercapto-beta-(2-furyl)acrylic acid (MFA), N-(N-mercaptopropionyl) glycine (MPG) and N-acetylcysteine (NAC) compared to spironolactone (SPL), a steroid, before and after 203 mercury (II) exposure, on the disposition of Hg and induction of tissue metallothionein (MT), was investigated in rats. The pretreatment with SPL, MFA and MPG enhanced faecal elimination of Hg and reduced its accumulation in liver particularly, the "heat stable fraction" resulting in lowered hepatic MT induction. Neither the renal uptake of Hg nor induction of tissue MT was affected by pre-treatment with the chelating agents; SPL and MFA causing re-distribution of Hg among the renal sub-cellular fractions. The post-Hg exposure treatment with MFA enhanced the faecal and MPG the urinary excretion of Hg. However, both the chelating agents increased the hepatic burden of Hg as reflected in the subcellular fractions and increased MT contents indicating mobilization of Hg from other tissue binding sites. The post-treatment with MPG however, depleted renal Hg as reflected by the sub-cellular distribution, without affecting renal MT levels. The results show that MFA and MPG are more promising preventive than therapeutic agents in Hg intoxication acting as metal chelators.
Industrial Toxicology Research Centre, Lucknow, India.
S
S
Khandelwal
D N
DN
Kachru
S K
SK
Tandon
D000111:Acetylcysteine / Q000627:therapeutic use; D000179:Acrylates / Q000627:therapeutic use; D000818:Animals; D002614:Chelating Agents / Q000627:therapeutic use*; D008297:Male; D008628:Mercury / Q000493:pharmacokinetics*; D008630:Mercury Poisoning / Q000188:drug therapy*; D008631:Mercury Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains; D013148:Spironolactone / Q000627:therapeutic use; D008625:Tiopronin / Q000627:therapeutic use
D000179:Acrylates; D002614:Chelating Agents; D008631:Mercury Radioisotopes; D013148:Spironolactone; C015341:2-mercapto-3-furan-2-ylpropenoic acid; D008625:Tiopronin; D008628:Mercury; D000111:Acetylcysteine