Requirement of a compartmentalization for NADPH oxidizing site and peroxidase-H2O2 in the thyroid iodinating system.
In this study, it is shown that NADPH iodination occurs in a thyroid peroxidase-H2O2 system in presence of thyroglobulin, the normal iodination substrate. Previous data suggested that thyroid H2O2 generation is a NADPH-dependent system. Present results support the concept of a compartmentalization of the sites of NADPH oxidation and peroxidasic iodination.
INSERM-U. 96, Unité de Recherche sur la Glande Thyroide et la Régulation Hormonale, Bicêtre, France.
N
N
Ait Hammou
A
A
Virion
D
D
Deme
J
J
Pommier
D006861:Hydrogen Peroxide / Q000378:metabolism; D066298:In Vitro Techniques; D007454:Iodides / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D010084:Oxidation-Reduction; D010544:Peroxidases / Q000378:metabolism*; D013954:Thyroglobulin / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism*
D007454:Iodides; D009249:NADP; D013954:Thyroglobulin; D006861:Hydrogen Peroxide; D010544:Peroxidases