Molecular forms of dopamine beta-hydroxylase in rat superior cervical ganglion and adrenal gland.
Dopamine beta-hydroxylase (DBH) enzyme activity was associated in rat superior cervical ganglion with tetrameric DBH-A (294,000 D) and dimeric DBH-B (147,000 D) and in rat adrenal gland with DBH-A and a novel molecular form of DBH, defined as DBH-C, with a molecular weight of 125,000 D. Pretreatment of the rats with cycloheximide markedly reduced DBH activity without altering the molecular heterogeneity.
Heymans Institute of Pharmacology, University of Ghent, Medical School, Belgium.
N H
NH
Fraeyman
E J
EJ
Van de Velde
F H
FH
De Smet
D000311:Adrenal Glands / Q000201:enzymology*; D000818:Animals; D002499:Centrifugation, Density Gradient; D004299:Dopamine beta-Hydroxylase / Q000145:classification / Q000378:metabolism*; D005728:Ganglia, Sympathetic / Q000201:enzymology*; D008970:Molecular Weight; D051381:Rats; D013347:Subcellular Fractions / Q000201:enzymology
D004299:Dopamine beta-Hydroxylase