Synthesis and antitumor activity of aminoacid derivatives of the antimetastatic agent DM-COOK.
Esters and amides of N-(3,3-dimethyl-1-triazeno)benzoylamino acids have been synthesized as inhibitors of cell surface neutral proteases. Preliminary data on activity against P-388 lymphocytic leukemia are also reported.
Lassiani
L
L
Istituto di Chimica Farmaceutica, Università di Trieste, Italy.
de Nardo
M M
MM
Nisi
C
C
Varnavas
A
A
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008815:Mice, Inbred Strains; D009362:Neoplasm Metastasis; D014226:Triazenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D014226:Triazenes; C030838:1-(4-carboxyphenyl)-3,3-dimethyltriazene