Fractals in physiology and medicine.
Nonlinear dynamics, a branch of the basic sciences that studies complex physical systems, offers novel approaches to long-standing problems of physiological form and function. The nonlinear concept of fractals, introduced and developed over the last decade, provides insights into the organization of complex structures such as the tracheobronchial tree and heart, as well as into the dynamics of healthy physiological variability. Alterations in fractal scaling may underlie a number of pathophysiological disturbances, including sudden cardiac death syndromes.
Goldberger
A L
AL
Cardiovascular Division, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02215.
West
B J
BJ
D000465:Algorithms; D003663:Decision Trees; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D008168:Lung / Q000033:anatomy & histology / Q000502:physiology; D008962:Models, Theoretical; D009716:Numerical Analysis, Computer-Assisted; D010827:Physiology