Acetylation, deacetylation and hydroxylation of sulphamethoxazole and N4-acetylsulphamethoxazole in the snail Cepaea hortensis.
The snail Cepaea hortensis is able to acetylate and hydroxylate sulphamethoxazole in a similar way to man. About one percent deacetylation, but no hydroxylation of N4-acetysulphamethoxazole takes place. The relative rates of the metabolic pathways for hydroxylation and acetylation of sulphamethoxazole are equal.
Department of Clinical Pharmacy, Sint Radboud Hospital, University of Nijmegen, The Netherlands.
T B
TB
Vree
M L
ML
Vree
J F
JF
Nouws
D000107:Acetylation; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006900:Hydroxylation; D012908:Snails / Q000378:metabolism*; D013420:Sulfamethoxazole / Q000031:analogs & derivatives* / Q000378:metabolism*
C021282:N(4)-acetylsulfamethoxazole; D013420:Sulfamethoxazole