Dose-response relationship for translocation induction in spermatogonia of the crab-eating monkey (Macaca fascicularis) by chronic gamma-ray-irradiation.
The induction of reciprocal translocations in spermatogonia of the crab-eating monkey (Macaca fascicularis) by chronic gamma-irradiation (1.8 x 10(-5) Gy/min, about 0.024 Gy/22 h/day) was examined. The frequencies of translocation per cell were 0.15% at 0.3 Gy, 0.27% at 1.0 Gy and 0.33% at 1.5 Gy. The dose-response relationship for translocation yield was a linear one with a regression coefficient (b) of 0.16 x 10(-2). When the slope (b) of the regression line was compared with that at a high dose rate (0.25 Gy/min, b = 1.79 x 10(-2), it was clear that the induction rate of translocations after chronic gamma-irradiation was only about one-tenth of that after high-dose-rate irradiation. Thus, there was evidence for a pronounced dose-rate effect in the crab-eating monkey.
Division of Genetics, National Institute of Radiological Sciences, Chiba, Japan.
I
I
Tobari
Y
Y
Matsuda
X H
XH
Gu
J
J
Yamagiwa
T
T
Utsugi
M
M
Kitazume
M
M
Okamoto
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008252:Macaca fascicularis; D008297:Male; D012044:Regression Analysis; D013093:Spermatogonia / Q000528:radiation effects / Q000648:ultrastructure*; D013094:Spermatozoa / Q000648:ultrastructure*; D014178:Translocation, Genetic / Q000528:radiation effects*