pH and P.E.G.-400 effects on flucloxacillin absorption.
1. Intestinal clearances of flucloxacillin significantly decrease with the increase of pH, concomitantly with a decrease of the percent absorbed at 60 min. 2. The apparent rate constants for unionized (Ku) and ionized species are 0.173 min-1 and 0.017 min-1 respectively. 3. The addition of P.E.G.-400 at different concentrations significantly enhanced intestinal clearances of flucloxacillin parallel to an increase of net water flux from the lumen of the small intestine.
Nuñez-Vergara
L J
LJ
Laboratory of Pharmacology, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago.
Lemus
I R
IR
Squella
J A
JA
D000818:Animals; D003023:Cloxacillin / Q000031:analogs & derivatives*; D005436:Floxacillin / Q000493:pharmacokinetics*; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000378:metabolism; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011092:Polyethylene Glycols; D005436:Floxacillin; D003023:Cloxacillin