Muscle fiber composition and length-tension relationships in rats chronically exposed to alcohol.
Adult Fischer 344 rats were fed an alcohol diet (7-9 g/kg/day) for 12 weeks and were compared to pair-fed controls with regard to the contraction and fiber characteristics of the gastrocnemius and plantaris muscles of the leg. Muscles were isolated in situ with blood and nerve supplies intact. The muscles were stretched by 1 mm increments and were stimulated at each muscle length with a voltage (1 msec pulse) that had been observed to produce maximal twitch force at the initial muscle length. Maximal twitch tension was found to be only 10% less in alcohol than pair-fed rats and the increase in force resulting from stretching was approximately 15% less in alcohol than pair-fed rats. No significant changes in sciatic nerve conduction velocities were produced by alcohol exposure. Moreover, no significant differences in muscle weight or the number and size of Type I, Type IIa or Type IIb muscle fibers were observed. Although the 12 weeks of alcohol exposure affected muscle physiology and histology in the direction of increased impairment, the differences were not large enough to be statistically significant.
Edmonds
B T
BT
Department of Physiology, State University of New York, Buffalo.
Pendergast
D R
DR
Arabadjis
P G
PG
Hardacker
J W
JW
Chan
A W
AW
York
J L
JL
D000437:Alcoholism / Q000473:pathology* / Q000503:physiopathology; D000818:Animals; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D051381:Rats; D011916:Rats, Inbred F344
D000431:Ethanol