Animal model of cardiotoxicity: carbon monoxide induced ECG hypoxia masked in light narcosis.
Inhalation exposure of restrained conscious rats to carbon monoxide (1000 ppm, 120 min.) led to a peak carboxyhaemoglobine concentration of 40-45%. At this concentrations spontaneous motor activity was not affected significantly but the physical capacity at endurance run was depressed by 70%. From the 30th min. of exposure a typical two-phasic change in heart rate with initial tachycardia and obvious but unstable hypoxic changes in ECG were observed. Quieting of animals (light anesthesia with phenobarbitone; 100 mg/kg ip) removed almost completely all pathological changes. The level and fluctuations of functional requirements to the circulation seem thus substantial for the development of the cardiotoxic effects.
Institute of Hygiene and Epidemiology, Centre of Industrial Medicine and Occupational Diseases, Praha.
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H
Mikisková
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E
Frantík
D000758:Anesthesia; D000818:Animals; D002248:Carbon Monoxide / Q000633:toxicity*; D002263:Carboxyhemoglobin / Q000032:analysis; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D008954:Models, Biological; D009043:Motor Activity / Q000187:drug effects; D005082:Physical Exertion / Q000187:drug effects; D051381:Rats / Q000502:physiology*
D002248:Carbon Monoxide; D002263:Carboxyhemoglobin