Copper in urine and hair in Indian childhood cirrhosis.
In advanced Indian childhood cirrhosis (ICC) urine copper concentration was higher (range 416-103,448 mg/g creatinine) than in other hepatic diseases (range 67-10,303 mg/g creatinine). In early ICC urine copper concentration was more modestly raised (1188-9470 mg/g creatinine), but rose to high values (2222-42,819 mg/g creatinine) after a single dose of penicillamine 20 mg/kg. A post-penicillamine urinary copper:creatinine ratio greater than 10,000 mg/g supports a diagnosis of ICC. The concentration of copper in the hair, while increased in advanced ICC, is of no diagnostic value in early cases.
Patel
H R
HR
Department of Child Health, University of Leicester.
Bhave
S A
SA
Pandit
A N
AN
Tanner
M S
MS
D002675:Child, Preschool; D003300:Copper / Q000032:analysis / Q000652:urine*; D005260:Female; D006197:Hair / Q000032:analysis*; D006801:Humans; D007223:Infant; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000378:metabolism / Q000652:urine; D008297:Male
D003300:Copper