Aquatic toxicity of acrylates and methacrylates: quantitative structure-activity relationships based on Kow and LC50.
Recent EPA scrutiny of acrylate and methacrylate monomers has resulted in restrictive consent orders and Significant New Use Rules under the Toxic Substances Control Act, based on structure-activity relationships using mouse skin painting studies. The concern is centered on human health issues regarding worker and consumer exposure. Environmental issues, such as aquatic toxicity, are still of concern. Understanding the relationships and environmental risks to aquatic organisms may improve the understanding of the potential risks to human health. This study evaluates the quantitative structure-activity relationships from measured log Kow's and log LC50's for Pimephales promelas (fathead minnow) and Carassius auratus (goldfish). Scientific support of the current regulations is also addressed. Two monomer classes were designated: acrylates and methacrylates. Spearman rank correlation and linear regression were run. Based on this study, an ecotoxicological difference exists between acrylates and methacrylates. Regulatory activities and scientific study should reflect this difference.
3M Environmental Laboratory, St. Paul, Minnesota 55133-3331.
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D000179:Acrylates / Q000633:toxicity*; D000818:Animals; D005399:Fishes / Q000502:physiology; D007928:Lethal Dose 50; D008689:Methacrylates / Q000633:toxicity*; D013329:Structure-Activity Relationship; D014481:United States; D014484:United States Environmental Protection Agency; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D000179:Acrylates; D008689:Methacrylates; D014873:Water Pollutants; D014874:Water Pollutants, Chemical