RO 15-4513 does not protect rats against the lethal effects of ethanol.
In two separate research centres the ability of RO 15-4513 to protect rats against the lethal effects of ethanol (7.5 and 15 g/kg) was investigated. In neither study did RO 15-4513 offer protection against ethanol-induced lethality or the loss of righting reflex caused by these doses of ethanol. These data fail to replicate the results of an earlier report and suggest that RO 15-4513 is unlikely to be clinically useful treating acute severe ethanol toxicity.
Nutt
D J
DJ
Laboratory of Clinical Studies, NIAAA/DICBR, Bethesda, MD 20892.
Lister
R G
RG
Rusche
D
D
Bonetti
E P
EP
Reese
R E
RE
Rufener
R
R
D000818:Animals; D001386:Azides / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000633:toxicity; D008297:Male; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000187:drug effects; D013997:Time Factors
D001386:Azides; D001569:Benzodiazepines; D000431:Ethanol; C042957:Ro 15-4513