Acarboxyprothrombin concentration [corrected] after oral prophylactic vitamin K.
The effect of prophylaxis with oral vitamin K (1 mg vitamin K1 given with the first feed) on the rate of detection of acarboxyprothrombin (PIVKA II) and factor II clotting concentration [corrected] were analysed. Introducing such prophylaxis reduced the rates of detection of PIVKA II concentration [corrected] on day 5 from 48% to zero. None of the babies given prophylaxis had factor II clotting  concentration [corrected] below 40%, compared with 34 of 95 babies not given prophylaxis. This study has important implications in the prophylaxis of both classical and late onset haemorrhagic disease of the newborn.
von Kries
R
R
Department of Paediatrics, University of Düsseldorf, Federal Republic of Germany.
Kreppel
S
S
Becker
A
A
Tangermann
R
R
Göbel
U
U
D000284:Administration, Oral; D015415:Biomarkers; D001777:Blood Coagulation / Q000187:drug effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011498:Protein Precursors; D011516:Prothrombin / Q000031:analogs & derivatives* / Q000378:metabolism; D014812:Vitamin K / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D006475:Vitamin K Deficiency Bleeding / Q000517:prevention & control*
D015415:Biomarkers; D011498:Protein Precursors; D014812:Vitamin K; C008208:acarboxyprothrombin; D011516:Prothrombin