Effect of different fractions of Swertia chirayita on the blood sugar level of albino rats.
A 95% ethanol extract and four fractions of Swertia chirayita were tested for blood sugar lowering activity in rats when given orally at 250 mg/kg. The hexane fraction caused maximum lowering although the ethanol extract was clearly active. Of the four dose levels of the hexane fraction tested, 250 mg/kg was found to produce the optimum effect and 300 mg/kg did not evoke a better response. The optimum dose produced significant lowering of blood sugar in fed, glucose-loaded and tolbutamide-pretreated animal models, but not in fasted rats.
Sekar
B C
BC
Central Drug Research Institute, Lucknow, India.
Mukherjee
B
B
Chakravarti
R B
RB
Mukherjee
S K
SK
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D005502:Food; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D014044:Tolbutamide / Q000494:pharmacology
D001786:Blood Glucose; D010936:Plant Extracts; D014044:Tolbutamide