Influence of 70 percent pancreatic resection on serum and bone calcium in the rat--a preliminary report.
Four weeks after 70% resection of the pancreas in the rat, serum levels of calcium, inorganic phosphate, magnesium, parathyroid hormone and calcitonin, as well as femur dry weight, volume, mean specific density, and mineral content were investigated. The urinary excretion of cAMP and hydroxyproline was measured. Additionally, residual pancreatic amylase content, fasting blood levels of insulin, glucagon, somatostatin and glucose were determined, and the mineral balance (calcium, phosphate) studied. Residual pancreatic amylase content was decreased to 22% of control values, fasting serum glucose and plasma glucagon were increased. Fecal excretion of calcium and phosphate was unchanged, but their balance was increased. Serum calcitonin and the mean specific density of femurs were decreased. All the other variables were unchanged. We conclude that in the rat, 70% pancreatic resection 1) probably does not have any harmful effects on calcium metabolism and bone mineralization in the short term postoperatively, 2) provokes mild hyperglucagonemia, the molecular nature and the origin of which need further elucidation.
Department of Surgery, University of Erlangen, FRG.
J
J
Schmidtler
P O
PO
Schwille
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D008297:Male; D010179:Pancreas / Q000502:physiology*; D010180:Pancreatectomy; D051381:Rats; D011919:Rats, Inbred Strains
D002118:Calcium