[Metabolic characteristics of xenobiotics in the liver of tumor-bearing rats].
A study of the condition and function of a multienzymatic monoxygenase system in liver microsomes of rats bearing experimental Pliss' lymphosarcoma and Zajdela's ascites hepatoma showed synthesis and function of the key enzymes of the hydroxylating microsomes of the liver being inhibited and, consequently, drug metabolism slowed down.
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Komov
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Firsova
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Vennikas
D000632:Aminopyrine / Q000493:pharmacokinetics; D000814:Aniline Compounds / Q000493:pharmacokinetics; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D015786:Cytochromes b5; D004790:Enzyme Induction / Q000187:drug effects; D006900:Hydroxylation; D008114:Liver Neoplasms, Experimental / Q000201:enzymology*; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009368:Neoplasm Transplantation; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D000814:Aniline Compounds; D003573:Cytochrome b Group; D000632:Aminopyrine; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D000815:Aniline Hydroxylase; C023650:aniline; D010634:Phenobarbital
Osobennosti metabolizma ksenobiotikov v pecheni krys s opukholiami.