Prevention of endotoxin-induced leukocytic infiltration of lung with radio-detoxified endotoxin (TOLERIN) pretreatment.
Five mg of bacterial endotoxin (LPS) can provoke a serious leukocytic pulmonary infiltration in rats. The same dose of radiation-detoxified LPS (RD-LPS; 150 kGy 60Co-gamma irradiated) can produce only slight pulmonary infiltration. However, 100 micrograms RD-LPS--as pretreatment--can prevent the LPS-induced leukocytic infiltration of the lung.
Department of Pathology, City Hospital, Hatvan, Hungary.
L G
LG
Szabó
T
T
Tóth
G
G
Benedek
L
L
Bertók
D000818:Animals; D004731:Endotoxins / Q000528:radiation effects* / Q000627:therapeutic use; D005260:Female; D008168:Lung / Q000473:pathology; D011292:Premedication; D051381:Rats; D012128:Respiratory Distress Syndrome / Q000473:pathology / Q000517:prevention & control*
D004731:Endotoxins; C010797:tolerin