[Synthesis of tetracontapeptide--a hypothetical evolutionary precursor of calcium-binding proteins. I. Synthesis of (1-9), (10-14), (15-20), (21-26), (29-33), (34-40) fragments].
Fragments (1-9), (10-14), (15-20), (21-26), (29-33) and (34-40) of a tetracontapeptide hypothetical ancestor of calcium-binding proteins were synthesised with the use of pentafluorophenyl esters. Formation of a succinimide derivative was detected during synthesis of fragment (15-20) containing Asp(OBzl)-Gly sequence. To avoid this side process, tert-butylprotecting group was used instead of benzyl group. alpha-Carboxyls of C-terminal amino acids were protected by phenacyl group.
Grechishko
V S
VS
Medvedkin
V N
VN
Zapevalova
N P
NP
Jung
R
R
Mitin
Iu V
IuV
D005075:Biological Evolution; D002135:Calcium-Binding Proteins / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D010446:Peptide Fragments / Q000138:chemical synthesis*; D010455:Peptides / Q000138:chemical synthesis*; D011498:Protein Precursors / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared
D002135:Calcium-Binding Proteins; D010446:Peptide Fragments; D010455:Peptides; D011498:Protein Precursors
Sintez tetrakontapeptida--gipoteticheskogo évoliutsionnogo predshestvennika kal'tsiĭsviazyvaiushchikh belkov. I. Sintez fragmentov (1-9), (10-14), (15-20), (21-26), (29-33), (34-40).