The limits of ascertainment.
The concept of a proband, and a formula frequently used to give the probability that a family with r affected children has t probands, have led to frequently used, but incorrect, 'limits of ascertainment' in estimation problems involving ascertainment sampling. Data suggesting a sampling scheme outside these incorrect limits are discussed. An estimation procedure not using the proband concept is available which is not bounded by the incorrect limits.
Department of Mathematics, Monash University, Clayton, Victoria, Australia.
W J
WJ
Ewens
N C
NC
Shute
D002648:Child; D003198:Computer Simulation; D003625:Data Collection; D006801:Humans; D008957:Models, Genetic; D011336:Probability