Distribution of hemoglobin E and beta-thalassemia in Kampuchea (Cambodia).
The hemoglobin type of 360 adult Cambodian subjects was determined by cellulose acetate electrophoresis and microcolumn chromatography. The following distributions and frequencies of the Hb E (beta E) and the beta-thalassemia (beta-thal) genes were found: in a group of 264 Cambodians of rural areas 153 Hb A, 83 Hb AE, 19 Hb E, and nine beta-thalassemia minor (frequency beta E 0.2292, beta-thal 0.0170). In an urban group from the capital Phnom Penh there were 68 Hb A, 21 Hb AE, four Hb E, and three beta-thalassemia minor (frequency beta E 0.1510, beta-thal 0.0156). The low frequency of beta E in the urban group is probably due to Chinese admixture. Possible causes of the observed deficiency of Hb AE heterozygotes in comparison with Hardy-Weinberg equilibrium are discussed.
Sanguansermsri
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Department of Pathology, Faculty of Medicine, Chiangmai University, Thailand.
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D000328:Adult; D002160:Cambodia; D004588:Electrophoresis, Cellulose Acetate; D005787:Gene Frequency; D006446:Hemoglobin E / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D010641:Phenotype; D012424:Rural Population; D013789:Thalassemia / Q000453:epidemiology*; D014505:Urban Population
D006455:Hemoglobins, Abnormal; D006446:Hemoglobin E