The effect of auranofin on glucose uptake by the isolated vascularly perfused, small intestine of the rat.
Auranofin at a concentration of 2.5 micrograms/ml had no effect on glucose uptake by the viable, isolated, vascularly perfused, small intestine of the rat and no net movement of water was detected. No effect on glucose uptake or water movement was found when intestines from rats fed 0.1 mg/Kg body weight per day for 4 weeks were perfused with drug free medium. Mucosal damage was seen in 1 of 2 rats fed Auranofin and examined histologically.
McMaster
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Department of Medicine, Queen's University of Belfast, Northern Ireland.
Love
A H
AH
D000284:Administration, Oral; D000818:Animals; D001310:Auranofin / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism; D010477:Perfusion; D051381:Rats
D001310:Auranofin; D005947:Glucose