General method of synthesis for natural long-chain beta-diketones.
Two general methods of synthesis have been developed for the preparation of long-chain beta-diketones. The first relies on malonate-type alkylation of acid chlorides derived from fatty acids, while the second, more direct method, involves coupling and subsequent hydrolysis of long-chain acetylenes with acid chlorides of fatty acids.
Barbieri
G
G
Facultad de Quimica, Montevideo, Uruguay.
Seoane
G
G
Trabazo
J L
JL
Riva
A
A
Umpierrez
F
F
Radesca
L
L
Tubio
R
R
Kwart
L D
LD
Hudlicky
T
T
D000478:Alkylation; D055598:Chemical Phenomena; D002621:Chemistry; D005227:Fatty Acids / Q000032:analysis; D006868:Hydrolysis; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
D005227:Fatty Acids; D007659:Ketones