Relationship between extracellular potassium accumulation and local TQ-segment potential during acute myocardial ischemia in the porcine.
Depolarization of resting membrane potential during acute myocardial ischemia is strongly correlated with the accumulation of extracellular potassium ([K+]e). Also, diastolic currents of injury flowing across the ischemic border that occur as a result of local differences in resting membrane potentials cause changes in the TQ-segments of unipolar, DC-coupled, extracellular electrograms. Further, the changes in [K+]e and TQ-segment potentials during acute ischemia and reperfusion follow a similar time course. For these reasons, a predictable relationship between [K+]e and TQ potentials might be expected to exist. If found, easily obtainable local TQ potential measurements could serve as an index of the resting membrane depolarization induced by [K+]e accumulation and, by extension, as an index of ischemic injury. We measured local [K+]e and TQ potentials from 30 mid-myocardial sites in central and marginal ischemic zones in 2 isolated, Langendorff-perfused porcine hearts during a single, 10-min ligation of the left anterior descending coronary artery. In general, we found a linear relationship between [K+]e and TQ potential for both ischemic zones when data was taken as a whole, but the slopes (S) and correlation coefficients (R) were markedly different between the two locations (-2.24 vs -1.28 and -0.73 vs -0.51 for central and marginal zones, respectively). Further, we found a time dependent change in both S and R that was biphasic. Both were low during the first minutes, attained their maximum values at 4 mins, and then fell during the remainder of the occlusion. We conclude, therefore, that local TQ potentials cannot be used as an index of the severity of ischemic changes.(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Medicine, University of North Carolina, Chapel Hill.
T A
TA
Johnson
R
R
Coronel
C A
CA
Graebner
J W
JW
Buchanan
M J
MJ
Janse
L S
LS
Gettes
D000208:Acute Disease; D000818:Animals; D003327:Coronary Disease / Q000503:physiopathology*; D004562:Electrocardiography; D006321:Heart / Q000503:physiopathology*; D008564:Membrane Potentials; D011188:Potassium / Q000378:metabolism*; D013552:Swine
D011188:Potassium