[Nonsteroidal anti-inflammatory agents. V. Synthesis of 1-aryl-5-(1-pyrryl)-pyrazolyl-4-acetic acids with potential anti-inflammatory action].
The synthesis of 1-aryl-5-(1-pyrryl)pyrazoles bearing at position 4 an acetic or alpha-propionic chain is described. The new compounds can be structurally related to lonazolac and its analogues with analgesic-antiinflammatory activities. When tested pharmacologically in comparison with tolmetin and indomethacin none of the above derivatives showed any appreciable activity.
Corelli
F
F
Dipartimento di Studi Farmaceutici, Facolta' di Farmacia, Universita' di Roma La Sapienza.
Massa
S
S
Stefancich
G
G
Silvestri
R
R
Artico
M
M
Pantaleoni
G C
GC
Palumbo
G
G
Fanini
D
D
Giorgi
R
R
D000085:Acetates / Q000138:chemical synthesis*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles
Agenti antiinfiammatori non-steroidei. Nota V. Sintesi di acidi 1-aril-5-(1-pirril)pirazolil-4-acetici a potenziale attività antiinfiammatoria.