Renal tissue kallikrein in newborn and young SHR.
Since young SHR excrete less urinary kallikrein than WKY, active and total kallikrein (A and T Kall, respectively) was measured (amidolytic assay) in the renal cortex of both strains. Neither at birth nor at age 4 weeks did renal T Kall differ between SHR and WKY. Renal A Kall was significantly lower in newborn SHR and higher in 4-week-old-SHR than in age-matched WKY. Our results indicate that urinary kallikrein does not accurately reflect the renal enzyme activity. They suggest that SHR exhibit an inherited defect in prokallikrein activation and a secondary defect in the release of tissue kallikrein into urine.
Laboratory of Physiology, Medical School, Paul Sabatier University, Toulouse, France.
J L
JL
Ader
T
T
Tran-Van
F
F
Praddaude
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001794:Blood Pressure; D005260:Female; D006973:Hypertension / Q000378:metabolism* / Q000503:physiopathology; D007610:Kallikreins / Q000378:metabolism* / Q000652:urine; D007668:Kidney / Q000378:metabolism*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012016:Reference Values
D007610:Kallikreins