A comparative study on the uptake of ascorbic acid by the iris-ciliary body of the rabbit, guinea pig and rat.
1. The uptake of 14C-ascorbic acid by the iris-ciliary body in vitro was examined in the rabbit, guinea pig and rat. 2. It was observed that iris-ciliary body from the rabbit and guinea pig, but not the rat, accumulated 14C-ascorbate to levels exceeding that in the bathing medium. 3. In all three species, the uptake of 14C-ascorbate was diminished by cold temperature; the degree of uptake at 0 degrees C was similar in the rabbit, guinea pig and rat iris-ciliary body. 4. Chromatographic examination of the 14C accumulated by the rabbit and guinea pig tissue demonstrated that the label remains almost exclusively as 14C-ascorbate.
Department of Ophthalmology, University of Louisville School of Medicine, KY 40202.
N A
NA
Delamere
R N
RN
Williams
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D001692:Biological Transport; D002924:Ciliary Body / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D007498:Iris / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D001205:Ascorbic Acid