The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats.
The increased use of rats for laboratory studies has increased the urgency for a better understanding of their perception of painful or noxious stimuli and the means of obtunding such stimuli. Four different injectable drugs, pentobarbital, fentanyl-droperidol (Innovar-Vet), ketamine-xylazine and ketamine-diazepam, were evaluated in this study. Unlike previous studies in rodents, this study has quantitated noxious stimulus perception following a temporal sequence of observations. Results showed the greatest inhibition of noxious stimulus perception with Innovar-Vet, lesser inhibition with ketamine-xylazine and ketamine-diazepam, and the least obtunding of nociception with pentobarbital. Results of this study also suggested that a spatial orientation, similar to that present in man, exists within the CNS of rats for receipt of noxious stimulation.
Department of Comparative Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
S K
SK
Wixson
W J
WJ
White
H C
HC
Hughes
W K
WK
Marshall
C M
CM
Lang
D000758:Anesthesia / Q000662:veterinary*; D000777:Anesthetics; D000818:Animals; D003975:Diazepam; D004329:Droperidol; D004338:Drug Combinations; D005283:Fentanyl; D007649:Ketamine; D008297:Male; D009458:Neuroleptanalgesia / Q000662:veterinary*; D010146:Pain / Q000503:physiopathology / Q000662:veterinary*; D010147:Pain Measurement / Q000662:veterinary; D010424:Pentobarbital; D010465:Perception; D051381:Rats; D011919:Rats, Inbred Strains; D014991:Xylazine
D000777:Anesthetics; D004338:Drug Combinations; D014991:Xylazine; D007649:Ketamine; C001451:Innovar; D010424:Pentobarbital; D004329:Droperidol; D003975:Diazepam; D005283:Fentanyl