[Olfactory esthesioneuroma. Clinical, histological and therapeutic aspects; apropos of 6 cases].
On the basis of 6 cases, the authors review the clinical, histological and therapeutic aspects of olfactory esthesioneuromas. These rare tumours, showing varying rates and degrees of progression from one patient to another, generally have a severe prognosis. Diagnosis is based upon precise histological criteria which may be clarified by electromicroscopic data. In difficult cases it may be useful to seek the aid of immuno-histochemical techniques in order to demonstrate the presence in tumour cells of specific neuronal enolase and the labelling of such cells by anti-protein S-100 antibodies. The treatment of choice would appear to be radio-surgical completed by chemotherapy similar to that used in neuroblastomas.
Service ORL, Hôpital de Dourdan, Paris.
J P
JP
Toutée
M
M
Wassef
M D
MD
Brette
S
S
Harbon
C
C
Beauvillain
A
A
Valdazo
P
P
Tran Ba Huy
D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D005004:Ethmoid Bone / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D012886:Skull / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
Les esthésioneuromes olfactifs. Aspects cliniques, histologiques, et thérapeutiques; à propos de six observations.