Comparative study of the influence of an inhibitor of monoaminooxidase (nialamide) on the calcium and phosphorus metabolism in slow and fast-growing rats.
Nialamide was supplied to slow-growing animals in doses of 20 mg/100 g of diet for 15 or 30 days. The dose for fast-growing animals was 10 mg/100 g of diet. The digestive utilization of calcium and phosphorus decreases significantly when adult slow-growing rats receive the drug for 30 days. This fall is already important in fast-growing rats when they receive nialamide for only 15 days. In the same way the falls in the retention of calcium and phosphorus in adult rats are only evident when the period of treatment is through 30 days, even females being in negative balance of phosphorus. The amount of calcium retained decreases significantly in fast-growing rats and so does phosphorus impressively after only 15 days of treatment.
Department of Animal Physiology, Faculty of Pharmacy, University of Granada, Spain.
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D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006128:Growth / Q000187:drug effects*; D008297:Male; D009526:Nialamide / Q000494:pharmacology*; D010758:Phosphorus / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D010758:Phosphorus; D002118:Calcium; D009526:Nialamide