[Prognostic value of bone surface in hypothyroidism detected in neonatal period].
Bone maturation at the time of diagnosis has been considered as a prognostic factor of congenital hypothyroidism. Using bone area as an index of bone maturation, we have compared the psycho-intellectual outcome of infants with high bone area (group I) at time of diagnosis, with those with low area (group II), in a population of infants with congenital hypothyroidism detected by a neonatal screening program. We found that children from group I had better performances than those from group II whatever the age of the evaluation (1, 2, 5 or 7 years). Nevertheless, the verbal performances of children from group I remained weaker than their non verbal performances and in 7 among 54, the IQ was found to be lower than 90 with a possible relationship with the thyroid insufficiency (bad compliance to treatment) in only one of them.
Service de génétique et maladies héréditaires du métabolisme de l'enfant, Hôpital Claude-Huriez, CHRU, Lille, France.
M F
MF
Lebecq
J P
JP
Farriaux
D001846:Bone Development; D003409:Congenital Hypothyroidism; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000523:psychology; D007231:Infant, Newborn; D007360:Intelligence; D008137:Longitudinal Studies; D008297:Male; D011379:Prognosis; D011594:Psychometrics; D013997:Time Factors
Etude de la valeur pronostique de la surface osseuse dans l'hypothyroïdie dépistée en période néonatale.