gamma-Aminobutyric acid (GABA) uptake systems in human frontal cortex.
Synaptosomes prepared from human frontal cortex possessed two uptake systems for gamma-aminobutyric acid (GABA) with Km values of 1.9 and 20.6 microM respectively, and with Vmax values of 0.15 and 0.78 nmol/min/mg protein respectively. In this respect, human tissue preparations differed from cortical synaptosomes from rodents in that a third, low-affinity GABA uptake system was not detectable in human synaptosomes.
Department of Biochemistry, University of Saskatchewan, Saskatoon, Canada.
H S
HS
Sidhu
D G
DG
Munoz
J D
JD
Wood
D000368:Aged; D000818:Animals; D001692:Biological Transport; D002540:Cerebral Cortex / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism; D051381:Rats; D013045:Species Specificity; D013574:Synaptosomes / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid