Cyclic tetrapeptides with sequences related to HC toxin. Conformations and cation binding.
Peptides with sequences related to HC toxin (cyclo(LAla-DAla-L-Aoe-DPro] can adopt a conformation locked by three gamma turns. A "structure--spectroscopy characteristics" relationship is proposed. These peptides can complex Mg++ cations and the binding is accompanied by a transconformation of the peptide backbone. The relevance with the biological activity of the toxin is discussed.
Laboratory of Polyphasic System Physicochemistry--UA 330, Montpellier, France.
F
F
Heitz
F
F
Kaddari
A
A
Heitz
H
H
Raniriseheno
R
R
Lazaro
D000595:Amino Acid Sequence; D002412:Cations; D007202:Indicators and Reagents; D008958:Models, Molecular; D009842:Oligopeptides / Q000138:chemical synthesis*; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D011485:Protein Binding; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D014118:Toxins, Biological
D002412:Cations; D007202:Indicators and Reagents; D009842:Oligopeptides; D010456:Peptides, Cyclic; D014118:Toxins, Biological; C037654:HC toxin