Depression of lymphocyte response to mitogens in sheep infected with tick-borne fever.
Lymphocytes obtained from sheep experimentally infected with Cytoecetes phagocytophila, the causative agent of tick-borne fever, showed reduced blastogenesis induced by the mitogens phytohaemagglutinin and E. coli lipopolysaccharide. The period of reduced lymphocyte reactivity coincided with the period of parasitaemia and leucopenia.
University of Liverpool, Department of Veterinary Pathology, Leahurst, Neston, Wirral, U.K.
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Woldehiwet
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004536:Ehrlichia; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D008297:Male; D008623:Mercaptoethanol / Q000494:pharmacology; D008934:Mitogens / Q000494:pharmacology; D010835:Phytohemagglutinins / Q000494:pharmacology; D012288:Rickettsiaceae Infections / Q000276:immunology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology*
D008070:Lipopolysaccharides; D008934:Mitogens; D010835:Phytohemagglutinins; D008623:Mercaptoethanol; D004247:DNA