Respiratory function of rat brain mitochondria after hypobaric hypoxia and piracetam treatment.
After an acute hypobaric hypoxia the mitochondrial respiratory control index is reduced in consequence of a decreased active-state respiration. The finding is paralleled by decreased uncoupled respiration and a not significantly changed resting-state respiration. Long term hypoxic exposures show adaptive traits of this criterion of mitochondrial energy metabolism. The antihypoxic effect of piracetam may be reflected in a delayed normothermic in vitro aging of mitochondrial suspension.
Institute of Pharmacology and Toxicology, Medical Academy, Carl Gustav Carus, Dresden, GDR.
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Wustmann
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Petzold
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Kunz
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Fischer
D000818:Animals; D001921:Brain / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism; D007700:Kinetics; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D010889:Piracetam / Q000494:pharmacology*; D011312:Pressure; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats
D011760:Pyrrolidinones; D010889:Piracetam