On the biosynthesis of asperlicin and the directed biosynthesis of analogs in Aspergillus alliaceus.
Feeding of 14C-labeled amino acids to resting cells of Aspergillus alliaceus strongly supported the intuitive hypothesis that asperlicin is biosynthesized from tryptophan, anthranilate and leucine. The resting cell system was used also to prepare 25 asperlicin analogs via directed biosynthesis in presence of analogs of tryptophan and leucine.
Merck & Co., Inc., Rahway, New Jersey 07065-0900.
D R
DR
Houck
J
J
Ondeyka
D L
DL
Zink
E
E
Inamine
M A
MA
Goetz
O D
OD
Hensens
D000596:Amino Acids / Q000378:metabolism; D001230:Aspergillus / Q000378:metabolism*; D001570:Benzodiazepinones / Q000096:biosynthesis*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D005285:Fermentation
D000596:Amino Acids; D001570:Benzodiazepinones; D002766:Cholecystokinin; C046367:asperlicin