Chronic nicotine administration increases binding of [3H]domperidone in rat nucleus accumbens.
An apparent inverse relationship between smoking and Parkinson's disease prompted an investigation of the effect of chronic nicotine administration on dopaminergic and serotonergic receptors in rat brain. Nicotine, 0.8 mg/kg, was injected once daily, five times per week, for 6 weeks. In nucleus accumbens the Kd for [3H]domperidone was increased 2-4-fold, and the Bmax was increased 1.5-2-fold. No changes were observed in the binding of [3H]domperidone in caudate-putamen or in that of [3H]ketanserin in frontal cortex. It is concluded that chronic nicotine administration may have a suppressant effect on central nervous system release of dopamine that in pre-parkinsonian persons causes an aversion to the effects of smoking.
Department of Neurology, Mount Sinai School of Medicine, New York.
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Reilly
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Lapin
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Maker
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Lajtha
D000818:Animals; D001665:Binding Sites; D004294:Domperidone / Q000378:metabolism*; D007650:Ketanserin / Q000378:metabolism; D008297:Male; D009538:Nicotine / Q000008:administration & dosage* / Q000494:pharmacology; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D012686:Septal Nuclei / Q000378:metabolism*
D011954:Receptors, Dopamine; D004294:Domperidone; D009538:Nicotine; D007650:Ketanserin