[Pre- and postoperative irradiation of gastrointestinal tumors].
Evidence has been produced to the effect that the radiation doses sufficient to manage occult malignoma offsprings or metastases are much lower than those required to cope with primary tumours. This seems to support the assumption that five-day or twelve-day preoperative irradiation, using doses between 20 Gy and 30 Gy, is possible of a target area large enough to include adjacent lymph nodes, without any impairment of the operation proper and for much better rates of healing. This should apply particularly to rectum, stomach, and pancreas carcinomas. Preoperative irradiation should be preferred to postoperative irradiation, provided secured diagnosis, since radiosensitivity of tumour cells was found to decline and that of normal tissue to rise after surgery. Hence, therapeutic effectiveness of postoperative irradiation must be expected to decrease after each recurrence. Consultation with a radiotherapist, therefore, is recommended, prior to a recurrent operation. To improve therapeutic results, concentration at adequately furnished centres is demanded for patients with oesophagus, pancreas, and anal carcinomas.
Geschwulstklinik, Bereichs Medizin (Charité) der Humboldt-Universität zu Berlin.
K H
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Dallüge
D003131:Combined Modality Therapy; D005770:Gastrointestinal Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D011379:Prognosis; D011879:Radiotherapy Dosage
Zur prä- und postoperativen Bestrahlung gastrointestinaler Tumoren.