Effects of ranitidine on plasma clearance of indocyanine green in patients with liver cirrhosis.
The effects of ranitidine on plasma clearance of ICG were investigated in 68 cirrhotic patients (9 were positive for HBsAg, 33 were alcoholics and 26 had cryptogenic cirrhosis). The ICG clearance test was performed before and after ranitidine administration. In 31 patients treated with ranitidine (150 mg perorally), the plasma ICG clearance were 233.6 +/- 20.4 ml/min (mean +/- S.E.) and 239.2 +/- 20.5 ml/min before and after ranitidine, respectively. In the 37 treated with intravenous ranitidine 50 mg, the corresponding values were 205.4 +/- 17.7 ml/min and 206.4 +/- 17.9 ml/min. There was no significant change in the plasma clearance of ICG or the elimination rate constant after ranitidine administration. Even in patients with decompensated liver cirrhosis, no significant change was demonstrated in the plasma ICG clearance after ranitidine. These results led to the conclusions that ranitidine does not reduce the hepatic blood flow and that it is a safe and useful drug for the treatment of gastrointestinal tract bleeding in patients with liver cirrhosis.
First Department of Internal Medicine, School of Medicine, Mie University, Tsu, Japan.
Y
Y
Kosaka
Y
Y
Tameda
K
K
Okita
T
T
Takemoto
S
S
Sato
K
K
Okuda
H
H
Kameda
S
S
Yamamoto
T
T
Kamada
Y
Y
Muto
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D008103:Liver Cirrhosis / Q000097:blood*; D008111:Liver Function Tests; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D011899:Ranitidine / Q000494:pharmacology*
D011899:Ranitidine; D007208:Indocyanine Green