Esophageal stricture secondary to Stevens-Johnson syndrome.
We report a 7-year-old male with ampicillin-induced Stevens-Johnson syndrome with subsequent extensive skin, conjunctival, oropharyngeal, and laryngeal involvement. Over the next 5 months, he developed complete blindness and dysphagia. A barium swallow revealed absence of both right and left pyriform sinus, and a stricture involving the entire esophagus. Retrograde dilatations, complicated by malignant hyperthermia, have subsequently allowed for the difficult progression from an eight to a 40 French bougie. Eighteen months since the diagnosis of esophageal stricture, he has a normal appearing esophagus and is swallowing without difficulty.
Howell
C G
CG
Department of Surgery, Medical College of Georgia Hospitals and Clinics, Augusta.
Mansberger
J A
JA
Parrish
R A
RA
D000667:Ampicillin / Q000009:adverse effects; D002648:Child; D004106:Dilatation; D004940:Esophageal Stenosis / Q000209:etiology* / Q000628:therapy; D005774:Gastrostomy; D006801:Humans; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced / Q000150:complications*
D000667:Ampicillin