[Value of the dexamethasone suppression test in anorexia nervosa].
Patients suffering from anorexia nervosa were assessed for variables of weight, dexamethasone-suppression-test and depressive symptomatology at three stages of inpatient treatment. With increase of body weight we found a highly significant decrease of plasma cortisol concentrations and depressive symptoms. During refeeding there also was a significant association between the degree of weight deficit (in % of ideal body weight) and plasma cortisol level, but the dexamethasone-suppression-test-result did not correlate with depression scores. However in 8 patients whose clinical condition deteriorated although their weight remained stable the dexamethasone-suppression-test results became abnormal again. The authors hypothesize that--besides the effect of weight loss--the dexamethasone-suppression-test might reflect the influence of other psychobiological factors which still have to be investigated.
Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Philipps-Universität Marburg/Lahn.
B
B
Herpertz-Dahlmann
H
H
Remschmidt
D000293:Adolescent; D000856:Anorexia Nervosa / Q000175:diagnosis* / Q000523:psychology; D001835:Body Weight; D003866:Depressive Disorder / Q000175:diagnosis* / Q000523:psychology; D003907:Dexamethasone; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D011569:Psychiatric Status Rating Scales
D003907:Dexamethasone; D006854:Hydrocortisone
Der Aussagewert des Dexamethason-Suppressions-Testes bei Anorexia nervosa.