Central attenuation of baroreflex precedes the development of hypertension in DOCA-salt-treated rats.
To determine whether baroreflex is changed centrally before the development of hypertension in DOCA-salt treated rats, aortic depressor nerve was stimulated electrically 5 days after DOCA-salt treatment in urethane-anesthetized rats: compared with those of sham-operated control rats, blood pressure was not elevated in either awake or anesthetized rats. Aortic depressor nerve (ADN) stimulation elicited frequency-dependent vasodepressor, bradycardiac, and sympatho-inhibitory responses in both DOCA-salt-treated and control rats. However, the responses to ADN stimulation were significantly smaller in DOCA-salt-treated rats. These findings suggest that baroreflex is attenuated centrally before the development of hypertension and this attenuation may contribute to the pathogenesis of DOCA-salt hypertension.
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
K
K
Takeda
Y
Y
Nakamura
M
M
Oguro
S
S
Kawasaki
J
J
Hayashi
S
S
Tanabe
T
T
Nakata
L C
LC
Lee
S
S
Sasaki
M
M
Nakagawa
D000818:Animals; D001011:Aorta / Q000294:innervation; D001921:Brain / Q000502:physiology*; D002320:Cardiovascular Physiological Phenomena; D003900:Desoxycorticosterone; D004558:Electric Stimulation; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D011311:Pressoreceptors / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000502:physiology; D012965:Sodium Chloride; D013564:Sympathetic Nervous System / Q000502:physiology
D003900:Desoxycorticosterone; D012965:Sodium Chloride