Effect of cimetidine on the pharmacokinetics of theophylline.
1. The effect of the therapeutic doses of cimetidine (400 mg/twice daily) on theophylline metabolism in Jordanian volunteers was studied. 2. The administration of the above therapeutic cimetidine dose did not alter theophylline clearance and elimination half-life. 3. Cimetidine administration also failed to alter the elimination of theophylline metabolites in urine.
Faculty of Medicine, University of Jordan, Amman.
O
O
Shaheen
N A
NA
Sliman
W A
WA
Al-Turk
D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D013806:Theophylline / Q000493:pharmacokinetics*
D002927:Cimetidine; D013806:Theophylline