Recurrent breakpoints at 9q31 and 22q12.2 in extraskeletal myxoid chondrosarcoma.
A cytogenetic study of extraskeletal myxoid chondrosarcoma cells revealed a complex t(9;22;15)(q31;q12.2;q25) as a primary chromosome change. A reciprocal translocation involving identical breakpoints on chromosomes #9 and #22 in this tumor has been reported in the literature. We suggest that the breakpoints 9q31 and 22.q12.2 are associated with extraskeletal myxoid chondrosarcoma, a comparatively rare tumor of adulthood.
Roswell Park Memorial Institute, Buffalo, NY.
C
C
Turc-Carel
P
P
Dal Cin
U
U
Rao
C
C
Karakousis
A A
AA
Sandberg
D000368:Aged; D000369:Aged, 80 and over; D002813:Chondrosarcoma / Q000235:genetics*; D002871:Chromosome Banding; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic
D005819:Genetic Markers