Occupational asthma due to sodium iso-nonanoyl oxybenzene sulphonate, a newly developed detergent ingredient.
Research with sodium iso-nonanoyl oxybenzene sulphonate (SINOS) for use in a detergent product was complicated by the development of asthma in an atopic 38 year old laboratory technician. Inhalation challenge tests with nebulised SINOS solutions over a dose range of 0.01-32 micrograms gave reproducible late asthmatic reactions after the higher doses and an increase in bronchial responsiveness to methacholine. The magnitude of the late reaction was related to the challenge dose.
Hendrick
D J
DJ
Newcastle General Hospital.
Connolly
M J
MJ
Stenton
S C
SC
Bird
A G
AG
Winterton
I S
IS
Walters
E H
EH
D000328:Adult; D001249:Asthma / Q000139:chemically induced* / Q000175:diagnosis; D001557:Benzenesulfonates / Q000009:adverse effects*; D001985:Bronchial Provocation Tests; D003902:Detergents / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis; D013501:Surface-Active Agents / Q000009:adverse effects*
D001557:Benzenesulfonates; D003902:Detergents; D013501:Surface-Active Agents; C057121:isononanoyl oxybenzene sulfonate