[Synthesis and biological activity of peptides from interferon alpha A region 125-131].
Two peptides, IFN-(125-129) (RITLY-I) and [Arg7]IFN-(125-131) (RITLYLR-II), belonging to the putative immunologically active region of interferon alpha A (IFN) were synthesised by the solid-phase method. Both peptides suppress the delayed-type hypersensitivity reaction in vivo as assayed in mice. The peptide (II) either suppresses (0.01-0.1 mg/kg) or stimulates (approximately 1.0 mg/kg) antibody production in mice in response to sheep red blood cells.
I R
IR
Rituma
R E
RE
Vegner
G A
GA
Afanas'eva
E M
EM
Kukaĭn
G I
GI
Chipens
D000596:Amino Acids; D000818:Animals; D000917:Antibody Formation; D006801:Humans; D007370:Interferon Type I / Q000138:chemical synthesis* / Q000235:genetics / Q000494:pharmacology; D051379:Mice; D009154:Mutation; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000235:genetics / Q000494:pharmacology
D000596:Amino Acids; D007370:Interferon Type I; D010446:Peptide Fragments
Sintez i biologicheskaia aktivnost' peptidov raĭona 125-131 interferona alpha A.