[Biopharmaceutical aspects of the medicinal forms of cephalexin].
The rate of cephalexin release from various dosage forms such as tablets, capsules and suspensions manufactured by several firms was studied. In vivo studies showed that pharmacokinetic indices of the absorption depended on the rate of cephalexin release from the dosage forms. The proposed procedure for in vitro estimation of the cephalexin release rate reflects bioavailability of the antibiotic dosage forms and may be used in quality control of finished dosage forms.
G B
GB
Garsheva
L N
LN
Berezovskaia
L K
LK
Grakovskaia
D000818:Animals; D001682:Biological Availability; D001702:Biopharmaceutics; D002214:Capsules; D002506:Cephalexin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004285:Dogs; D011208:Powders; D012995:Solubility; D013535:Suspensions; D013607:Tablets; D013997:Time Factors
D002214:Capsules; D011208:Powders; D013535:Suspensions; D013607:Tablets; D002506:Cephalexin
Biofarmatsevticheskie aspekty lekarstvennykh form tsefaleksina.