Central mechanism of vinblastine inhibitory effect on experimental carcinogenesis.
In the experiments carried out on white male rats the effect of vinblastine on the development of malignant stomach tumours induced with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) has been studied. The combined administration of MNNG and vinblastine inhibits the experimental carcinogenesis at the stage of "intestinalization" and decreases the indicence of stomach adenocarcinomas by 3-fold. Pharmacological analysis using the application of apomorphine stereotypy showed the antagonism of MNNG and vinblastine at the level of central parts of the autonomic nervous system due to the inhibition of axoplasmic transport of catecholamines. These results confirm the earlier data on the essential role of catecholamines in the mechanisms of carcinogenic action of nitrosamines.
N.N. Petrov Research Institute of Oncology, USSR Ministry of Public Health; Leningrad.
V K
VK
Gurkalo
N I
NI
Volfson
G B
GB
Pliss
D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D008297:Male; D008769:Methylnitronitrosoguanidine; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D014747:Vinblastine / Q000494:pharmacology*
D008769:Methylnitronitrosoguanidine; D014747:Vinblastine