Hemispheric disconnection syndrome persisting after anterior cerebral artery aneurysm rupture.
Hemispheric disconnection syndrome is a rarely reported sequela of aneurysm rupture. Serial neurobehavioral examinations of such a patient after clipping of a right pericallosal artery that had bled into a large portion of the corpus callosum disclosed defects in interhemispheric transfer of information and competitive movements between the left and right extremities. Although the patient's postoperative memory deficit subsequently resolved, his disconnection syndrome persisted and was primarily responsible for his disability despite otherwise normal neurological findings. We studied a second patient with a hematoma in the genu of the corpus callosum secondary to an arteriovenous malformation (AVM). Although the second patient also exhibited postoperative memory problems, her hemispheric disconnection symptoms were minimal and commensurate with a more circumscribed corpus callosum lesion. Neurobehavioral sequelae of aneurysm or AVM rupture involving the anterior circulation, which may be overlooked in the absence of a detailed examination, can produce persistent disability in many patients.
Division of Neurosurgery, University of Texas Medical Branch, Galveston.
H S
HS
Levin
F C
FC
Goldstein
S Y
SY
Ghostine
R L
RL
Weiner
M J
MJ
Crofford
H M
HM
Eisenberg
D000328:Adult; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology; D007839:Functional Laterality; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000000981:diagnostic imaging; D007806:Language Disorders / Q000209:etiology / Q000503:physiopathology; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D012422:Rupture, Spontaneous; D014057:Tomography, X-Ray Computed