Reye's syndrome-like illness in a patient receiving amiodarone.
A 16-yr-old boy who was receiving amiodarone for ventricular arrhythmias developed a Reye's syndrome-like illness several days after an upper respiratory infection. Liver biopsy revealed microvesicular fat and spotty hepatocellular necrosis, typical of Reye's syndrome. Recovery was complete. This case report suggests that medications other than aspirin may predispose to Reye's syndrome, and that children receiving amiodarone should receive prophylaxis against influenza B and chicken pox.
Jones
D B
DB
Liver Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
Mullick
F G
FG
Hoofnagle
J H
JH
Baranski
B
B
D000293:Adolescent; D000638:Amiodarone / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D012202:Reye Syndrome / Q000139:chemically induced* / Q000473:pathology
D000638:Amiodarone