Age-related changes in the noradrenergic innervation of the coronary arteries in old rats: a fluorescent histochemical study.
Age-related changes in the density of the noradrenergic perivascular plexus supplying the coronary vessels in the rat were studied using the glyoxylic acid fluorescence technique. A marked decrease in the density of the noradrenergic innervation of large, medium and small size coronary arteries was observed in 25-month-old rats. In contrast, the fluorescent nerves supplying the coronary veins were not decreased in old animals. The present data are indicative of an age-related reduction of fluorescent noradrenergic nerves in the rat coronary arteries.
Dipartimento di Sanita' Pubblica e Biologia Cellulare, Universita' Tor Vergata, Rome, Italy.
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D000375:Aging / Q000502:physiology*; D000818:Animals; D001158:Arteries; D003331:Coronary Vessels / Q000294:innervation*; D005453:Fluorescence; D006651:Histocytochemistry; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000502:physiology*