Peripheral artery thrombolysis with urokinase-lys-plasminogen. A disappointing experience.
Thirty-five patients with peripheral arterial occlusion were treated by intra-arterial infusion of low dose urokinase associated with bolus of lys-plasminogen. Systemic fibrinolysis was moderate, thrombolysis was achieved in 26 patients (74%). Only one patient required blood transfusion, five patients (14%) had distal emboli. Infection at the catheter entry site occurred in 2 patients, 3 patients experienced proximal embolism. Six patients required leg amputation, 4 died, in 2 of them deaths were related to arterial catheterization. Local thrombolysis with limited systemic fibrinolysis is associated to a high rate of catheter-related complications.
Chair de Clinique Médicale et de Pathologie Vasculaire, Hôpital Broussais, Paris, France.
J N
JN
Fiessinger
J F
JF
Vitoux
J M
JM
Pernes
M
M
Roncato
M
M
Aiach
J G
JG
Gaux
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000628:therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006083:Graft Occlusion, Vascular / Q000628:therapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D007511:Ischemia / Q000628:therapy; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000008:administration & dosage*; D010958:Plasminogen / Q000008:administration & dosage*; D012008:Recurrence; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
D010446:Peptide Fragments; C018998:lysyl-plasminogen; D010958:Plasminogen; D014568:Urokinase-Type Plasminogen Activator