Random brick model for drug transport across stratum corneum.
A model for drug permeation across the stratum corneum is developed to predict the effect of the physical configuration and chemical composition of the stratum corneum on the skin permeability of drugs. The experimental data of percutaneous absorption across different skin specimens are well interpreted by the present model.
Controlled Drug Delivery Research Center, Rutgers University, College of Pharmacy, Piscataway, NJ 08855-0789.
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Tojo
D001692:Biological Transport; D004058:Diffusion; D006801:Humans; D008954:Models, Biological; D010539:Permeability; D010599:Pharmacokinetics; D012869:Skin Absorption