Usefulness of blood parameters, especially viscosity, for the diagnosis and elucidation of pathogenic mechanisms of the hand-arm vibration syndrome.
In the present study it was found that, in vibrating-tool operators with Raynaud's phenomenon, whole blood viscosity was significantly higher than in operators without Raynaud's phenomenon at shear rates from 230 to 11.5 s-1. In addition rats were experimentally exposed to local vibration (60 Hz, 5 g) on their hind limbs for 4 h/d for 30 or 90 d. In the case of 30-d exposure, the small arteries in the exposed site did not change. However, after exposure for 90 d, disruption of the internal elastic lamina was observed in the small arteries. The disruption was followed by focal cell proliferation with regenerative formation of collagen and elastic fibers. The fibro-cellular thickening of the intima was further augmented, and, in addition, a complete stenosis of the small lumen of the small artery was observed. Medial thickness did not show significant differences between the control and exposed groups for either exposure duration. The whole blood viscosity was significantly increased by the 90-d but not by the 30-d exposure. These results suggest that there are some relationships between the increase in whole blood viscosity and the intimal thickening of some small arteries in the exposed site.
Department of Public Health, School of Medicine, Kanazawa University, Japan.
A
A
Okada
R
R
Inaba
T
T
Furuno
S
S
Nohara
M
M
Ariizumi
D000818:Animals; D001132:Arm; D001158:Arteries / Q000473:pathology; D001809:Blood Viscosity; D006225:Hand; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000097:blood* / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains; D011928:Raynaud Disease / Q000097:blood* / Q000209:etiology; D014732:Vibration / Q000009:adverse effects*