[Antiarrhythmic properties of the anticonvulsant drug benzonal].
In experiments on albino rats benzonal was found to exert an antiarrhythmic effect on models of chloride calcium-, aconitine- and strophantine-induced arrhythmias. In chloride calcium- and aconitine-induced arrhythmias its effect was qualitatively similar to that of diphenine, however it was inferior by the value of ED50 as compared with the latter. The advantage of benzonal over diphenine was its low toxicity.
Saratikov
A S
AS
Fateeva
S N
SN
Forshkova
V K
VK
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents; D000927:Anticonvulsants / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D001463:Barbiturates / Q000494:pharmacology* / Q000633:toxicity; D002122:Calcium Chloride; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051381:Rats; D013328:Strophanthins
D000889:Anti-Arrhythmia Agents; D000927:Anticonvulsants; D001463:Barbiturates; D013328:Strophanthins; D002122:Calcium Chloride; D000157:Aconitine; C002915:benzobarbital
Antiaritmicheskie svoĭstva protivosudorozhnogo preparata benzonala.