Effect of melatonin on intraocular pressure.
We studied the effect of orally administered melatonin on intraocular pressure in humans. We suppressed serum melatonin levels by exposing our subjects to bright light. Our experiments suggest that melatonin lowers intraocular pressure in man. This may prove to be a therapeutically useful agent since melatonin appears to be relatively free of side effects and is effective in small quantities.
Samples
J R
JR
Department of Ophthalmology, Oregon Health Sciences University, Portland 97201.
Krause
G
G
Lewy
A J
AJ
D000284:Administration, Oral; D002940:Circadian Rhythm; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects* / Q000528:radiation effects; D008027:Light; D008550:Melatonin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000652:urine
D008550:Melatonin; C012365:6-hydroxymelatonin