Two year electrophysiology follow-up in quinine amblyopia. A case report.
A 19-year-old girl presenting with quinine amblyopia had serial electrophysiology studies over a 2 year period. Visually evoked responses and the electro-oculogram were abolished early. By 2 months the VER and visual acuity had returned to normal. The electroretinogram, initially mildly subnormal, became virtually abolished by 2 months. No recovery in cone function took place. Of the rods 50% regained function with normal latency by 1 year, but receptor sensitivity did not return to normal until 2 years after ingestion. The electro-oculogram also recovered slowly over a 2 year period. This pattern suggest that quinine exerts a direct toxic effect on the cells of the outer retina and pigment epithelium, as well as on the ganglion cells.
Moloney
J B
JB
Research Foundation, Royal Victoria Eye and Ear Hospital, Dublin, Ireland.
Hillery
M
M
Fenton
M
M
D000328:Adult; D000550:Amblyopia / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D004596:Electroretinography; D005074:Evoked Potentials, Visual / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011803:Quinine / Q000506:poisoning*; D014792:Visual Acuity / Q000187:drug effects
D011803:Quinine