Lymphomatoid granulomatosis of the lung: report of a case and gene rearrangement studies.
Lymphomatoid granulomatosis is an uncommon but well-described entity which is currently thought to represent either a variant of malignant lymphoma from its outset or a benign yet prelymphomatous lesion. We recently studied such a case in a 70-year-old man who presented with bilateral pulmonary nodules on chest x-ray. Open lung biopsy and wedge resection revealed the typical histologic changes of lymphomatoid granulomatosis and immunohistochemical studies demonstrated a T cell proliferation. Genetic analysis of frozen tissue by Southern blot DNA hybridization showed no evidence of rearrangements of either the T cell receptor or immunoglobulin genes. This supports the notion that at least some cases of lymphomatoid granulomatosis may be part of a spectrum of premalignant lymphoproliferative disease rather than being frank malignant lymphoma from their outset.
Bleiweiss
I J
IJ
Department of Pathology, Mount Sinai Medical Center, New York, NY 10029.
Strauchen
J A
JA
D000368:Aged; D004247:DNA / Q000235:genetics; D005803:Genes, Immunoglobulin; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D008230:Lymphomatoid Granulomatosis / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D008297:Male; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D011995:Recombination, Genetic
D011948:Receptors, Antigen, T-Cell; D004247:DNA