A clinically significant interaction between ciprofloxacin and theophylline.
We report a case of theophylline toxicity following the co-administration of ciprofloxacin. Total theophylline clearance fell from 2.3 l.h-1 to 0.8 l.h-1 when ciprofloxacin was added to the treatment regimen and returned to 2.1 l.h-1 after ciprofloxacin was discontinued.
Department of Materia Medica, University of Glasgow, UK.
A H
AH
Thomson
G D
GD
Thomson
M
M
Hepburn
B
B
Whiting
D000368:Aged; D000369:Aged, 80 and over; D002939:Ciprofloxacin / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D013806:Theophylline / Q000009:adverse effects* / Q000493:pharmacokinetics
D002939:Ciprofloxacin; D013806:Theophylline