Evidences against a primary role for the pituitary neural lobe in the development and maintenance of DOC-salt hypertension.
The role of the antidiuretic hormone (ADH) in the development and maintenance of the hypertensive state produced by deoxycorticosterone (DOC) and salt in rats is a matter of controversy. The effects of neural lobe lesions that would prevent the release of the hormone to the systemic circulation without affecting the hypothetical release from the hypothalamic nuclei to other areas of the central nervous system was tested. A diabetes insipidus-like syndrome was obtained. But, neither the delay in the onset nor the development of DOC-salt hypertension was modified. This lesion made in rats at 3-4 weeks post DOC-salt did not alter the hypertension during the following 3 more weeks of treatment. These results suggest that the neural lobe would not be essential for the development and maintenance of DOC-salt hypertension in rats.
Instituto de Investigaciones Cardiológicas, Buenos Aires, Argentina.
M A
MA
Cannata
A C
AC
Taquini
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone / Q000494:pharmacology*; D006973:Hypertension / Q000209:etiology*; D008297:Male; D010904:Pituitary Gland, Posterior / Q000293:injuries / Q000502:physiology*; D051381:Rats; D014667:Vasopressins / Q000097:blood*
D014667:Vasopressins; D003900:Desoxycorticosterone