Effect of oral or intravenous pentoxifylline on ocular and optic nerve blood flow.
The effect of oral and intravenous pentoxifylline administration on ocular and optic nerve blood flow was studied in phakic rabbit eyes using a radioactive microsphere (85Sr) technique. Blood flow measurements were performed either 30 min after intravenous injection of 20 mg of pentoxifylline, or 2-3 h after oral administration of 20 mg of pentoxifylline. Blood flow measurements were determined for the iris, scraped ciliary processes, choroid, retina, and optic nerve. The only statistically significant difference noted was for blood flow in the optic nerve in the oral- versus intravenous-treated groups. Neither was significantly different from the control group.
Department of Ophthalmology, University of Arkansas for Medical Sciences, Little Rock.
W M
WM
Jay
M Z
MZ
Aziz
J M
JM
Chapman
K
K
Green
D000284:Administration, Oral; D000818:Animals; D005123:Eye / Q000098:blood supply*; D005260:Female; D007262:Infusions, Intravenous; D008297:Male; D009900:Optic Nerve / Q000098:blood supply*; D010431:Pentoxifylline / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D013805:Theobromine / Q000031:analogs & derivatives*
D013805:Theobromine; D010431:Pentoxifylline