Investigation into the mechanism of copper uptake by Mycoplasma gallisepticum in the presence of 2,9-dimethyl-1,10-phenanthroline.
In the presence of copper certain 2,2'-bipyridyls show antimycoplasmal activity, whereas copper itself causes a toxic effect. In this paper results are presented to elucidate the mechanism of copper uptake in the presence of 2,9-dimethyl-1,10-phenanthroline. The time course of copper and/or ligand uptake under the applied conditions is consistent with a carrier transport mechanism in which 2,9-dimethyl-1,10-phenanthroline operates as a carrier for copper ions. The influence of valinomycin on copper uptake indicates that the transmembrane potential is not the driving force in the carrier process.
Gaisser
H D
HD
Department of Pharmacochemistry, Free University, Amsterdam, The Netherlands.
van der Goot
H
H
Stouthamer
A H
AH
Timmerman
H
H
D001692:Biological Transport / Q000187:drug effects; D002352:Carrier Proteins; D003300:Copper / Q000493:pharmacokinetics*; D008564:Membrane Potentials / Q000187:drug effects; D009174:Mycoplasma / Q000187:drug effects / Q000378:metabolism*; D010618:Phenanthrolines / Q000493:pharmacokinetics / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D014634:Valinomycin / Q000494:pharmacology
D002352:Carrier Proteins; D010618:Phenanthrolines; D014634:Valinomycin; D003300:Copper; C002701:neocuproine; D011188:Potassium