Opiate involvement in contrast media-induced blood pressure changes.
The intravenous administration of contrast media (CM) often alters blood pressure (BP). Osmolality plays a role, but the magnitude and even direction of change varies under similar (osmotic) conditions, indicating the involvement of other mechanisms. Male Wistar rats, anesthetized with pentobarbital, received sodium/meglumine diatrizoate, iohexol, or normal saline, 4 ml/kg, via a tail vein, while blood pressure was recorded continuously. Additional groups were pretreated with the opiate antagonist, naloxone (1 mg/kg, IV), or with an equal volume of normal saline 5 minutes prior to the diatrizoate injection. Comparisons of BP change were made with the Student's t-test. Diatrizoate caused a significant (P less than .0002) increase in BP relative to the saline control group, iohexol did not. Thus, the increase with diatrizoate was significantly greater than with iohexol (P less than .00006). Neither the saline nor naloxone pretreatment altered BP significantly. Saline pretreatment did not alter the significant increase in BP produced by the diatrizoate. However, the diatrizoate-induced increase in BP was prevented by the naloxone pretreatment and was significantly less than after the saline pretreatment (P less than .0001). Based on these and previous results, the authors hypothesize that release of endogenous opioids may play a role in BP changes caused by intravenous CM and that significant CM-induced changes may be prevented pharmacologically with the selective opiate blocker, naloxone.
Harnish
P P
PP
Department of Radiology, University of Rochester Medical Center, New York 14642.
Mukherji
M
M
Northington
F K
FK
Kido
D K
DK
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000008:administration & dosage / Q000494:pharmacology; D004723:Endorphins / Q000378:metabolism / Q000502:physiology*; D007275:Injections, Intravenous; D007472:Iohexol / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D013268:Stimulation, Chemical
D003287:Contrast Media; D004723:Endorphins; D003974:Diatrizoate Meglumine; D007472:Iohexol