Substituted spiro[isoxazolidine-3,2'-tricyclo[3.3.1.1(3,7)]decane] derivatives.
The preparation and potential anti-inflammatory activity of a series of novel substituted spiro[isoxazolidine-3,2'-tricyclo[3.3.1.1(3,7)]decanes] (7, 11-30) are reported. The synthesis of the title compounds was accomplished via a 1,3-dipolar cycloaddition reaction of nitrones with appropriate olefins.
Mullen
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GB
Department of Organic Chemistry, Pennwalt Corporation, Rochester, NY 14623.
Swift
P A
PA
Georgiev
V S
VS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D002351:Carrageenan; D055598:Chemical Phenomena; D002621:Chemistry; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D010080:Oxazoles / Q000138:chemical synthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007555:Isoxazoles; D010080:Oxazoles; D013141:Spiro Compounds; D002351:Carrageenan