Pentagastrin protects the proximal small intestine against indomethacin-induced ulcers in the rat.
The possible protective effects of pentagastrin on indomethacin-induced small intestinal ulceration were investigated in rats. Ulcers were induced by subcutaneous injection of 30 mg/kg indomethacin, 30 min after refeeding rats fasted for 24 h. Administration of pentagastrin at a dose of 250 or 400 micrograms/kg i.p., 3 h prior to refeeding, reduced total ulcer area from 27.6 +/- 6.5 to 7.2 +/- 1.97 mm2 (mean +/- SEM; p less than 0.02) in the proximal small intestine only. Cyclic adenosine monophasphate, but not prostaglandin E2 levels were significantly raised by 250 micrograms/kg pentagastrin (0.15 +/- 0.05 vs. 0.38 +/- 0.07 pmol/mg protein; mean +/- SEM; p less than 0.02) in the same intestinal segment.
Harel
L
L
Pediatric Gastroenterology Unit, Beilinson Medical Center, Petah Tiqva, Israel.
Zahavi
I
I
Marcus
H
H
Waisman
Y
Y
Ligumsky
M
M
Rosenbach
Y
Y
Dinari
G
G
D000818:Animals; D004381:Duodenal Ulcer / Q000139:chemically induced* / Q000517:prevention & control; D007213:Indomethacin / Q000633:toxicity*; D007413:Intestinal Mucosa / Q000187:drug effects; D008297:Male; D010418:Pentagastrin / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D010418:Pentagastrin; D007213:Indomethacin