Effect of enzyme inducer flumecinolum (Zixoryn) on aminophylline metabolism in rats.
The effect of the enzyme inducer flumecinolum, m-trifluoromethyl-alpha-ethylbenzhydrol (Zixoryn), on aminophylline metabolism was examined in rats. Aminophylline plasma levels were determined by HPLC. Aminophylline T1/2 was 2.85 hours (r = 0.9353) in the pretreated group and 3.75 hours (r = 0.9471) in the untreated control group. Flumecinolum was found to accelerate the elimination of aminophylline and the effect became significant 3.92 hours after the administration of aminophylline.
Clinical Pharmacology and Pathophysiological Research Unit, National Korányi, Institute for TBC and Pulmonology, Budapest, Hungary.
A
A
Szeitz
E
E
Huszár
I
I
Herjavecz
K
K
Vértes
L A
LA
Debreczeni
D000628:Aminophylline / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001559:Benzhydryl Compounds; D000628:Aminophylline; C016914:flumecinol