Comparison of the effect of aminoglycosides on excretion of N-acetyl-beta-glucosaminidase.
Urinary N-acetyl-beta-glucosaminidase (NAG) activity was determined in ten patients receiving 200 mg of astromicin and ten patients receiving 100 mg of dibekacin; each dose was administered twice a day for five days. There was a significant difference between the aminoglycosides in the rate at which NAG activity increased, suggesting that astromicin has a lower nephrotoxicity.
Department of Urology, National Medical Center Hospital, Tokyo, Japan.
K
K
Fujita
T
T
Murayama
M
M
Kawamura
K
K
Narita
D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D000368:Aged; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000652:urine; D003982:Dibekacin / Q000633:toxicity*; D005260:Female; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D007612:Kanamycin / Q000031:analogs & derivatives*; D007668:Kidney / Q000187:drug effects; D008297:Male; D008875:Middle Aged
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003982:Dibekacin; D007612:Kanamycin; C023384:fortimicin A; D003404:Creatinine; D006596:Hexosaminidases; D000118:Acetylglucosaminidase