Adrenocortical insufficiency associated with Epstein-Barr virus infection in a patient with the Wiskott-Aldrich syndrome.
A 10-year-old boy with the Wiskott-Aldrich syndrome developed adrenocortical insufficiency including typical clinical findings, low s-Na, high s-K, high p-ACTH (640 ng/l), low p-aldosterone (33-39 pmol/l), high p-renin (2300-4200 mIU/l) as well as an abnormal response to an ACTH-stimulation test. The adrenocortical insufficiency developed concomitantly with the occurrence of infectious mononucleosis diagnosed clinically and serologically. Adrenalitis caused by Epstein-Barr virus is suggested as the causative factor.
University Clinic of Pediatrics, Department G, Rigshospitalet, Copenhagen, Denmark.
N T
NT
Hertel
B B
BB
Jacobsen
F K
FK
Pedersen
C
C
Heilmann
D000293:Adolescent; D000309:Adrenal Insufficiency / Q000150:complications* / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D036022:Capsid Proteins; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications* / Q000276:immunology; D008297:Male; D014923:Wiskott-Aldrich Syndrome / Q000150:complications* / Q000276:immunology
D000956:Antigens, Viral; D036022:Capsid Proteins; C041788:Epstein-Barr viral capsid antigen