Comparison of some haemodynamic parameters determined by invasive methods as well as by the noninvasive radionuclide estimation of the left ventricular ejection fraction in conscious and anaesthetized dogs.
An attempt was made to elaborate an optimal method for noninvasive radionuclide determination of left ventricular ejection fraction in conscious and lightly anaesthetized dogs, as well as to assess the value of this procedure in estimating cardiac functional state. Repeated determinations in the same animals have shown that the 45 degree left anterior oblique position (LAO-45) for imaging is optimal, giving the most uniform values of the calculated left ventricular ejection fraction. Neither the latter, nor the haemodynamic parameters (LVSP, LVEDP and dP/dt) determined by invasive methods were changed by light pentobarbital anaesthesia (20 mg/kg i. v.). Results confirm the validity of noninvasive radionuclide determination of left ventricular ejection fraction for estimation of the functional state and of the pharmacological actions on the latter in both conscious and anaesthetized animals.
Mester
J
J
Department of Pharmacology, University Medical School, Szeged, Hungary.
Udvary
E
E
Végh
A
A
Láng
J
J
Csernay
L
L
Szekeres
L
L
D000790:Angiocardiography; D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D006321:Heart / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013318:Stroke Volume; D016276:Ventricular Function