The effect of chronic digitalis therapy on the course of heart failure and on endocrine function in cardiomyopathic hamsters.
Eleven month old cardiomyopathic hamsters, which have enlarged hearts and anasarca, were given access to either an ethanol vehicle or an ethanol-digoxin solution in addition to a second water bottle. In comparison to controls, treated hamsters survived and showed significant amelioration of the pathological syndrome of heart failure. Thus, in this model of advanced congestive failure, digoxin has a clear-cut beneficial effect.
Primate Neuro-behavioral Unit, VA Medical Center, East Orange NJ.
J E
JE
Ottenweller
W N
WN
Tapp
B H
BH
Natelson
D000818:Animals; D009202:Cardiomyopathies / Q000188:drug therapy*; D006224:Cricetinae; D004071:Digitalis Glycosides / Q000627:therapeutic use*; D004702:Endocrine Glands / Q000187:drug effects*; D006333:Heart Failure / Q000188:drug therapy*; D006728:Hormones / Q000097:blood; D008297:Male; D008647:Mesocricetus; D009929:Organ Size / Q000187:drug effects
D004071:Digitalis Glycosides; D006728:Hormones