Pharmacokinetics of oxfendazole in goats: a comparison with sheep.
In goats, there was a linear correlation of area under the plasma concentration-time curve (AUC) with dose in the range 0-20 mg/kg as single dosages of oxfendazole (OFZ). The bioavailability of OFZ after oral administration was lower in goats than in sheep. The repetition of three administrations at 24 h intervals produced significant increase in the AUC in comparison with a single administration equivalent to the total dosage (1 X 5.0 and 3 X 1.7 mg/kg). Infection with O. circumcincta produced a 33% decrease in the bioavailability of OFZ.
Department of Veterinary Pharmacology, Veterinary School of Glasgow, U.K.
J
J
Bogan
E
E
Benoit
P
P
Delatour
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D006041:Goats / Q000378:metabolism*; D007275:Injections, Intravenous / Q000662:veterinary; D010029:Ostertagiasis / Q000378:metabolism / Q000662:veterinary; D012756:Sheep / Q000378:metabolism*
D000871:Anthelmintics; D001562:Benzimidazoles; C011030:oxfendazole