A semiconductive polymer film sensor for glucose.
The electrical conductivity of organic polymers such as polyacetylene and its derivatives can be varied over twelve orders of magnitude with small amounts (0-3%) of various dopants, such as iodine, bromine, and perchloric acid. Semiconductive polyacetylene film doped with iodine is sensitive to hydrogen peroxide, and can be used as a quantitative hydrogen peroxide sensor. A rapid, quantitative sensor for glucose, using the flavoprotein glucose oxidase, is described and introduces a novel electroactive material, polyacetylene, as the basis for a new biosensor. A significant increase in the sensitivity of this device has been obtained by mediating the doping reaction through lactoperoxidase and potassium iodide.
Ohmicron Corporation, Pennington, New Jersey 08534.
M K
MK
Malmros
J
J
Gulbinski
W B
WB
Gibbs
D000114:Acetylene / Q000031:analogs & derivatives; D004563:Electrochemistry; D004566:Electrodes; D005947:Glucose / Q000032:analysis*; D005949:Glucose Oxidase; D007202:Indicators and Reagents; D007455:Iodine; D011108:Polymers; D053279:Polyynes
D007202:Indicators and Reagents; D011108:Polymers; D053279:Polyynes; D007455:Iodine; D005949:Glucose Oxidase; D005947:Glucose; D000114:Acetylene