Activities of five new fluoroquinolones against Pseudomonas pseudomallei.
Thirty-four isolates of Pseudomonas pseudomallei were tested by a broth microdilution technique for susceptibility to amifloxacin, ciprofloxacin, enoxacin, norfloxacin, and ofloxacin. Ciprofloxacin was the most active agent tested, with an MIC for 90% of the strains tested of 8 micrograms/ml. These in vitro results suggest that the fluoroquinolones tested would not be optimal for therapy of melioidosis.
Winton
M D
MD
Division of Infectious Diseases, University of Missouri-Columbia 65212.
Everett
E D
ED
Dolan
S A
SA
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003470:Culture Media; D008826:Microbial Sensitivity Tests; D011549:Pseudomonas / Q000187:drug effects*; D011804:Quinolines / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D011804:Quinolines