Bromocriptine-unresponsive prolactin macroadenoma in a prepubertal female.
Macroprolactinomas occur rarely in prepubertal children. A prepubertal 11 10/12-year-old female with a macroprolactinoma presented with a diagnosis of anorexia nervosa. Findings included severe headaches, anorexia, weight loss, and growth failure. The initial serum prolactin level was 2,916 ng/ml. This value fell after beginning treatment with bromocriptine, but later rose despite a doubling of the dose. Transsphenoidal surgical resection was performed and postoperative radiation given. The use of bromocriptine, surgical resection, and radiation therapy in the treatment of macroprolactinomas are discussed.
Cheyne
K L
KL
Department of Pediatrics, University of Arizona, Tuscon 85724.
Lightner
E S
ES
Comerci
G D
GD
D000236:Adenoma / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D001971:Bromocriptine / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D010911:Pituitary Neoplasms / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D011388:Prolactin / Q000378:metabolism*; D011628:Puberty, Delayed / Q000209:etiology
D001971:Bromocriptine; D011388:Prolactin