[Bromsulphalein clearance in persons in occupational contact with pesticides].
In 46 persons (sprayers, disinfectors, technicians of the agricultural aviation) the bromsulphalein clearance is traced, during the active work season with pesticides, after the method of Caroly, Nys and Alliot. It is established, that the mean value of bromsulphalein clearance (8.91%) is lower than that of the referent group healthy persons (14.5%). In 14 (31.34%) of the examined the values of the clearance are under 10%. The changes of the last do not correlate closely to other indices of the liver function. As an explanation of the results the authors presuppose general pathogenetic relations between the metabolism of pesticides and of bromsulphalein in the liver cell, with inclusion of glutathione-S-transferase systems. The study allows to give a practical conclusion for the meaning of the bromsulphalein clearance and assessment of the pesticides effect in persons who are in professional contact with them.
G
G
Mechkov
V
V
Petkova
N
N
Zakhariev
D000328:Adult; D000383:Agriculture; D002031:Bulgaria; D004781:Environmental Exposure; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D010575:Pesticides / Q000009:adverse effects*; D013448:Sulfobromophthalein / Q000493:pharmacokinetics*
D010575:Pesticides; D013448:Sulfobromophthalein
Klirens na bromsulfaleina u litsa v profesionalen kontakt s pestitsidi.