[The actions and properties of sodium nucleinate used as a pyrogen working standard. 3. Changes in the leukocyte picture of rabbits following intravenous injection of sodium nucleinate].
In rabbits, the i.v. injection of a sodium nucleinate solution, like a solution of bacterial pyrogen administered in the same way, at first induces leucopenia, followed by leucocytosis. The fraction of pseudoeosinophiles increases, while that of lymphocytes decreases.
Institut für Arzneimittelwesen der DDR, Berlin.
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D000818:Animals; D004804:Eosinophils / Q000187:drug effects; D007275:Injections, Intravenous; D007958:Leukocyte Count / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects; D009696:Nucleic Acids / Q000494:pharmacology*; D011749:Pyrogens / Q000494:pharmacology*; D011817:Rabbits
D009696:Nucleic Acids; D011749:Pyrogens; C013683:sodium nucleinate
Uber Wirkungen und Eigenschaften des als Pyrogen-Arbeitsstandard verwendeten Natriumnucleinats. 3. Mitteilung: Anderungen des weissen Blutbildes von Kaninchen nach intravenöser Injektion von Natriumnucleinat.