Three possible triggers to induce thrombocytopenia in dengue virus infection.
Changes in platelet count by dengue virus-platelet interaction and the participation of anti-DV antibody to such changes were studied in vitro with the aim to investigate a mechanism of how the DV causes prominent thrombocytopenia characteristically seen in DHF. The results obtained showed that: (1) DV antigen attached to human platelets without immune-mediated reaction, (2) a decrease in platelet count was more markedly demonstrated by the binding of anti-DV antibody on the DV antigen associated with platelets than by the binding of the antigen-antibody complex on platelets, (3) a modulation of endothelial cell by the infection of DV to the cell was suggested as one of the causes of the thrombocytopenia.
Funahara
Y
Y
Department of Physiology, Kobe University School of Medicine, Japan.
Ogawa
K
K
Fujita
N
N
Okuno
Y
Y
D000936:Antigen-Antibody Complex / Q000276:immunology; D000937:Antigen-Antibody Reactions; D001792:Blood Platelets / Q000276:immunology; D003715:Dengue / Q000150:complications*; D003716:Dengue Virus / Q000276:immunology; D004727:Endothelium / Q000166:cytology / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D013921:Thrombocytopenia / Q000209:etiology*
D000936:Antigen-Antibody Complex