Induction of sperm abnormalities in mice by ifosfamide and trofosfamide.
The antitumor drugs ifosfamide (IF) and trofosfamide (TF) were evaluated for their capability to induce sperm abnormalities in (C3H X C57BL/6)F1 mice. A statistically significant increase in teratospermia was observed at the 35th day after 5 daily consecutive intraperitoneal injections of the drugs at doses of 25, 50, 100 mg/kg b.w. of TF and 100 mg/kg b.w. of IF. Thus, IF and TF are able to interfere with the differentiation process of spermatogenic cells.
Quinto
I
I
Institute of Cellular and Molecular Biochemistry, 2nd Medical School, University of Naples, Italy.
De Marinis
E
E
De Dominicis
G
G
Della Morte
R
R
Staiano
N
N
D000818:Animals; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D004822:Epididymis / Q000166:cytology; D007069:Ifosfamide / Q000494:pharmacology / Q000633:toxicity*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009929:Organ Size / Q000187:drug effects; D013076:Sperm Count / Q000187:drug effects; D013094:Spermatozoa / Q000002:abnormalities* / Q000187:drug effects; D013737:Testis / Q000033:anatomy & histology
D003520:Cyclophosphamide; C003726:trofosfamide; D007069:Ifosfamide