Effects of pralidoxime applied locally into the midbrain reticular formation on the hippocampal theta rhythm induced by acetylcholinesterase inhibition.
After local administration into the midbrain reticular formation of an acetylcholinesterase reactivator--Pralidoxime, a significant decrease of intensity of hippocampal theta rhythm induced by previous inhibition of acetylcholinesterase by DFP was observed already after 10 min. This result suggests that cholinergic structures are localized in midbrain reticular formation and that they play a role in the origin of hippocampal theta rhythm.
Department of Pharmacology, Military Institute of Hygiene and Epidemiology, Warsaw.
M
M
Kowalczyk
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004569:Electroencephalography; D006624:Hippocampus / Q000502:physiology*; D007267:Injections; D007531:Isoflurophate / Q000494:pharmacology; D008297:Male; D008636:Mesencephalon / Q000502:physiology*; D011220:Pralidoxime Compounds / Q000494:pharmacology*; D011817:Rabbits; D012154:Reticular Formation / Q000502:physiology*; D013826:Theta Rhythm
D002800:Cholinesterase Inhibitors; D011220:Pralidoxime Compounds; D007531:Isoflurophate; C028797:pralidoxime