Serotonin condensation product 5-hydroxymethtryptoline: evidence for in vivo formation from acetaldehyde during intoxication using deuterium labelled ethanol.
Trideuterated 5-hydroxymethtryptoline was found in the urine of rats treated with trideuterated ethanol. The combined treatment with disulfiram lead to a more than 10-fold increase in the excretion rate. The chiral analysis revealed unequal abundance of enantiomers suggesting the involvement of a stereoselective (enzymatic) mechanism in the formation 5-hydroxymethtryptoline during ethanol intoxication.
Pasarow Analytical Neurochemical Facility, Nancy Pritzker Laboratory of Behavioral Neurochemistry, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305.
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Beck
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Tyler
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Faull
D000079:Acetaldehyde / Q000378:metabolism*; D000435:Alcoholic Intoxication / Q000378:metabolism*; D000818:Animals; D002243:Carbolines / Q000378:metabolism*; D000431:Ethanol / Q000493:pharmacokinetics*; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*
D002243:Carbolines; C035602:6-hydroxy-1-methyltryptoline; D012701:Serotonin; D000431:Ethanol; D000079:Acetaldehyde