Novel mRNA species from a Q-subregion class-I gene of the murine major histocompatibility complex.
A novel mRNA species is specified by the Q6/Q8 gene, a member of the Qa-2-determining family of class-I genes of the murine major histocompatibility complex. It is longer than all previously described class-I transcripts due to an extension at the 3' end of the mRNA past the predicted polyadenylation site. This mRNA was detected by Northern-blot analyses with single or low-copy-number probes to the 3' end of the Q6/Q8 gene. RNase protection experiments have confirmed this finding. The appearance of this mRNA in different strains of mice correlates with the synthesis of the Qa-2 molecule.
Department of Microbiology and Immunology, Albany Medical College, NY 12208.
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Elliott
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Karl
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Flaherty
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D002874:Chromosome Mapping; D005805:Genes, MHC Class I; D006649:Histocompatibility Antigens / Q000235:genetics*; D015395:Histocompatibility Antigens Class I; D051379:Mice / Q000235:genetics*; D008970:Molecular Weight; D005810:Multigene Family; D012333:RNA, Messenger / Q000235:genetics
D000954:Antigens, Surface; D006649:Histocompatibility Antigens; D015395:Histocompatibility Antigens Class I; C032907:Q surface antigens; D012333:RNA, Messenger