Muscle adenosine 5'-triphosphate and creatine phosphate concentrations in relation to nutritional status and sepsis in man.
1. Intramuscular concentrations of adenosine 5'-triphosphate (ATP) and creatine phosphate were measured in the vastus lateralis muscle of 28 non-septic malnourished patients and 31 septic malnourished patients. Similar measurements were made on the rectus abdominis muscle of about one-third of these patients. All results were compared with those obtained from 15 normally nourished non-septic control subjects. 2. Objective measurements of nutritional status (both anthropometric and biochemical) and sepsis were recorded in all subjects. 3. The vastus lateralis muscle of the non-septic and septic malnourished patients had intramuscular concentrations of ATP and total adenine nucleotides (TAN) that were up to 30% lower than control values, depending on the reference base used. 4. In the rectus abdominis muscle, ATP and TAN concentrations were up to 60% lower than control values, and creatine phosphate up to 47% lower, again depending on the reference base used. 5. In both muscles, the changes were more marked in those patients who were septic as well as malnourished.
Department of Surgery, University of Manchester Medical School, U.K.
J C
JC
Tresadern
C J
CJ
Threlfall
K
K
Wilford
M H
MH
Irving
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000150:complications / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D009748:Nutrition Disorders / Q000150:complications / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism*
D010725:Phosphocreatine; D000255:Adenosine Triphosphate