Neurotoxicity of monosodium-L-glutamate in pregnant and fetal rats.
Monosodium-L-glutamate given subcutaneously to pregnant rats caused acute necrosis of the acetylcholinesterase-positive neurons in the area postrema. The same effect has been observed in the area postrema of fetal rats. The process of neuronal cell death and the elimination of debris by microglia cells proved to be similar in pregnant animals and in their fetuses. However, embryonal neurons were more sensitive to glutamate as judged by the rapidity of the process and the dose-response relationship. These observations raise the possibility of transplacental poisoning in human fetuses after the consumption of glutamate-rich food by the mother.
Department of Anatomy, University Medical School, Szeged, Hungary.
L
L
Tóth
S
S
Karcsu
J
J
Feledi
G W
GW
Kreutzberg
D000110:Acetylcholinesterase / Q000032:analysis; D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000196:embryology / Q000473:pathology*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D005971:Glutamates / Q000633:toxicity*; D008854:Microscopy, Electron; D009336:Necrosis; D009474:Neurons / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012970:Sodium Glutamate / Q000633:toxicity*
D005971:Glutamates; D000110:Acetylcholinesterase; D012970:Sodium Glutamate