Cobalt plaque versus enucleation for uveal melanoma: comparison of survival rates.
Two hundred and twenty-three patients treated by cobalt plaque for uveal melanoma were compared with 416 patients treated by enucleation for uveal melanoma in terms of patient survival. The median follow-up time for the patients treated by cobalt plaque was 4.3 years. Kaplan-Meier survival curves were calculated up to five years following treatment based on time to tumour-related deaths. Cox's proportional hazards multivariate analysis was performed to determine which variables were related to melanoma-related deaths while controlling for age, size, and location of the tumours. Statistically significant predictive factors were location of tumour and largest tumour dimension. There was not a statistically significant difference in survival between patients treated by cobalt plaque and those treated by enucleation.
Adams
K S
KS
Department of Ophthalmology, Manhattan Eye, Ear and Throat Hospital, New York, New York 10021.
Abramson
D H
DH
Ellsworth
R M
RM
Haik
B G
BG
Bedford
M
M
Packer
S
S
Seddon
J
J
Albert
D
D
Polivogianis
L
L
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D006801:Humans; D008545:Melanoma / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D008875:Middle Aged; D013997:Time Factors; D014604:Uveal Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery
D003037:Cobalt Radioisotopes