[Local treatment of cervical intraepithelial neoplasia with a 5 percent fluorouracil ointment].
The results of treatment of histologically proven cervical intraepithelial neoplasia (CIN) in 10 women are described. Two of them had CIN I and 8 CIN III. All patients had a application of 5 g 5 per cent 5-fluorouracil cream in a cervical cup daily over a period of 12 hours for one week. All 10 patients have been examined colposcopically, cytological and by biopsy following therapy. In 8 women cone biopsie were done 6-12 months afterwards for having a final diagnosis 2 patients having CIN I pretherapeutically were follow up for 16 months with cytology, colposcopy and punch biopsy. In 6 cases we found better findings (Twice complete healing, twice only CIN I and twice CIN II as residues). In 4 cases severe dysplasia and carcinoma in situ could be found in endocervix. Based on these results were recommended more (not only one) treatment cycles for local efficient chemotherapy using 5 per cent 5-fluorouracil cream.
Barten
G
G
Klinik für Gynäkologie und Geburtshilfe, Bereichs Medizin der Wilhelm-Pieck-Universität Rostock.
D001706:Biopsy; D002278:Carcinoma in Situ / Q000188:drug therapy* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002584:Cervix Uteri / Q000473:pathology; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D009367:Neoplasm Staging; D009824:Ointments; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology
D009824:Ointments; D005472:Fluorouracil
Lokale Behandlung der cervikalen intraepithelialen Neoplasie (CIN) mit einer 5%igen 5-Fluorourazil-Salbe.