Effects of Panax ginseng extract on the benzo(a)pyrene metabolizing enzyme system.
Ethanol extract of Panax ginseng C. A. Meyer, which has been used for centuries as a tonic in Asian countries, exhibited a selective induction of epoxide hydratase and cytosolic glutathione transferase activity without the concurrent induction of aryl hydrocarbon hydroxylase activity. Thus, Panax ginseng appears to have the potential to alter the metabolic patterns of benzo(a)pyrene and its reactive metabolites.
Lee
F C
FC
Korea Ginseng & Tobacco Research Institute, Daejeon.
Park
J K
JK
Ko
J H
JH
Lee
J S
JS
Kim
K Y
KY
Kim
E K
EK
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D001564:Benzo(a)pyrene / Q000378:metabolism*; D004851:Epoxide Hydrolases / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007723:Korea; D008297:Male; D005894:Panax / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains
D010936:Plant Extracts; D001564:Benzo(a)pyrene; D001189:Aryl Hydrocarbon Hydroxylases; D005982:Glutathione Transferase; D004851:Epoxide Hydrolases