Cardiopulmonary function during 5 hours of constant-dose isoflurane in laterally recumbent, spontaneously breathing horses.
Hemodynamic and respiratory effects of 5 h of unvarying 1.57%, end-tidal (1.2 MAC) isoflurane in O2 anesthesia were characterized in ten left laterally recumbent horses. Compared to base line values at 30 min of constant dose isoflurane, cardiac output, hematocrit, total plasma solids, PaCO2, and peak inspired gas flow progressively and significantly (P less than 0.05) increased over the course of study. Arterial blood pressure increased (P less than 0.05) during the first 2 h of constant dose of isoflurane then decreased and remained near base line values. Inspiratory time progressively decreased with time of anesthesia. All horses recovered from anesthesia uneventfully within 1 h of termination of isoflurane.
Department of Surgery, Veterinary Medical Teaching Hospital, School of Veterinary Medicine, Davis, CA.
E P
EP
Steffey
D S
DS
Hodgson
C I
CI
Dunlop
M F
MF
Miller
M J
MJ
Woliner
R B
RB
Heath
J
J
Grandy
D000769:Anesthesia, Inhalation / Q000662:veterinary; D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006400:Hematocrit / Q000662:veterinary; D006439:Hemodynamics / Q000187:drug effects*; D006736:Horses / Q000502:physiology*; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D010366:Peak Expiratory Flow Rate / Q000662:veterinary; D012119:Respiration / Q000187:drug effects*; D013318:Stroke Volume / Q000187:drug effects; D013997:Time Factors
D007530:Isoflurane