Isolation, identification and in vitro synthesis of conjugates of penbutolol and its metabolites.
The metabolites of 1-tert.-butylamino-3-(2-cyclopentylphenoxy)propan-2-ol (penbutolol Betapressin) penbutolol 2-glucuronide, 4'-OH-penbutolol 2-glucuronide, 4'-OH-penbutolol 4'-sulfate and 1''-dehydropenbutolol 2-glucuronide were isolated from the urine of patients, purified by high-performance liquid chromatography and characterised by 1H-NMR and mass spectroscopy. Penbutolol 2-glucuronide and 4'-OH-penbutolol 4'-glucuronide were synthesised in vitro from penbutolol and 4'-OH-penbutolol, respectively, using glucuronyltransferase.
Lehr
K H
KH
Hoechst Aktiengesellschaft, Frankfurt/Main (Fed. Rep. of Germany).
Damm
P
P
Fehlhaber
H W
HW
Hajdù
P
P
D000818:Animals; D001711:Biotransformation; D002417:Cattle; D005965:Glucuronates / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D013058:Mass Spectrometry; D010394:Penbutolol / Q000378:metabolism* / Q000652:urine; D011412:Propanolamines / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013431:Sulfates / Q000378:metabolism
D005965:Glucuronates; D011412:Propanolamines; D013431:Sulfates; D010394:Penbutolol