An acquired Robertsonian translocation dic(14;14)(p11;p11) in a patient with a myelodysplastic syndrome following treatment of multiple myeloma.
Acquired Robertsonian translocations are considered to be very rare chromosome changes in human malignancy, and only three cases have been described. We report a dic(14;14)(p11;p11) in a patient with myelodysplastic syndromes (MDS) following treatment for multiple myeloma. This patient also had other complex chromosomal abnormalities. The pattern of karyotype evolution in this patient was established by a series of cytogenetic studies. The relationship of the complex chromosomal changes to MDS following treatment for multiple myeloma is discussed.
Fan
Y S
YS
Department of Genetics and Endocrinology, Roswell Park Memorial Institute, Buffalo, NY 14263.
Baer
M R
MR
Sait
S N
SN
Dal Cin
P
P
Prentice
T C
TC
Preisler
H D
HD
Sandberg
A A
AA
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002871:Chromosome Banding; D002883:Chromosomes, Human, Pair 14; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000532:radiotherapy; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000235:genetics*; D014178:Translocation, Genetic / Q000187:drug effects
D000970:Antineoplastic Agents; D005819:Genetic Markers