A possible role for calmodulin in Ca2+-induced swelling of mitochondria.
Ca2+-induced mitochondrial swelling was inhibited by a low concentration of calmodulin antagonists. Two affinities of Ca2+ to mitochondrial swelling were observed: high (2-5 microM) and low (more than 100 microM) systems. The high-affinity change was inhibited by micromolar level of trifluoperazine and W-7, but not by W-5. The possible mechanism of this inhibition and the role of CaM in mitochondria are discussed.
Dept. of Physiology, Kagawa Medical School, Japan.
O
O
Hatase
T
T
Itano
H
H
Matsui
A
A
Doi
S
S
Etoh
H
H
Nishio
S
S
Nakahara
D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology*; D002147:Calmodulin / Q000037:antagonists & inhibitors / Q000502:physiology*; D066298:In Vitro Techniques; D008027:Light; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D008933:Mitochondrial Swelling / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012542:Scattering, Radiation; D013449:Sulfonamides / Q000494:pharmacology; D014268:Trifluoperazine / Q000494:pharmacology
D002147:Calmodulin; D013449:Sulfonamides; D014268:Trifluoperazine; C017967:W 7; D002118:Calcium