Regional distribution of blood flow of dogs during graded dynamic exercise.
The regional blood flow response to progressive treadmill exercise was measured with radioactive microspheres in 25 untrained mongrel dogs. Incremental increases in work intensity resulted in corresponding increases in blood flows to the gracilis, gastrocnemius, semimembranosus, and semitendinosus muscles of the hindlimb and to the heart. During maximal exercise, blood flow was greatest in the semimembranosus muscle and lowest in the semitendinosus muscle (342 and 134 ml-1.100 g tissue-1.min-1, respectively). Exercise produced a decrease in blood flow to the temporalis muscle, which was classified as nonlocomotive in function. Blood flows to the stomach, pancreas, and large intestine decreased at the lowest exercise work load and remained diminished throughout the continuum to maximal exercise. Blood flows to the small intestine and spleen were maintained during submaximal exercise but were reduced by 50% at maximal O2 consumption (VO2max). No changes in blood flows to the kidneys, adrenal glands, liver, and brain were found. These results demonstrate that 1) renal blood flow is maintained at resting levels during exercise in untrained dogs; 2) blood flow changes in the various organs of the splanchnic region of dogs during exercise are heterogeneous; and 3) blood flows to the working skeletal muscles of dogs progressively increase with increasing work loads up to VO2max.
Musch
T I
TI
Department of Internal Medicine, University of Texas Health Science Center, Southwestern Medical School, Dallas 75235.
Friedman
D B
DB
Pitetti
K H
KH
Haidet
G C
GC
Stray-Gundersen
J
J
Mitchell
J H
JH
Ordway
G A
GA
D000818:Animals; D002302:Cardiac Output; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D003964:Diaphragm / Q000098:blood supply / Q000000981:diagnostic imaging; D004064:Digestive System / Q000098:blood supply / Q000000981:diagnostic imaging; D004285:Dogs / Q000502:physiology*; D006339:Heart Rate; D006614:Hindlimb / Q000098:blood supply / Q000000981:diagnostic imaging; D007773:Lactates / Q000097:blood; D008863:Microspheres; D010101:Oxygen Consumption; D005082:Physical Exertion; D011877:Radionuclide Imaging; D012039:Regional Blood Flow
D007773:Lactates