Plasma and liver concentrations of alpha-tocopherol in weaner sheep after vitamin E supplementation.
Changes in the plasma and liver concentrations of alpha-tocopherol in sheep kept in an animal house, grazed on pasture, grazed on pasture and fed an oat/lupin grain supplement, or grazed on toxic lupin stubble were monitored following no, oral or intramuscular administration of alpha-tocopherol. It was concluded that intramuscular administration was most effective because it caused longer periods of elevated plasma alpha-tocopherol concentrations in most situations investigated and consistently higher concentrations of alpha-tocopherol in the liver, compared to oral administration. The dose rates of alpha-tocopherol given, the vehicle for alpha-tocopherol in the injectable preparation, the different diets consumed and the concurrent occurrence of lupinosis all influenced the results. In spite of this a significant positive correlation existed between the terminal liver and plasma alpha-tocopherol concentrations.
Doncon
G H
GH
Animal Health Laboratories, Department of Agriculture, South Perth, Western Australia.
Steele
P
P
D000818:Animals; D008099:Liver / Q000032:analysis*; D008297:Male; D012756:Sheep / Q000378:metabolism*; D014810:Vitamin E / Q000008:administration & dosage* / Q000032:analysis / Q000097:blood*
D014810:Vitamin E