[Human albumin therapy and prognostic value of determining colloid osmotic pressure at the surgical intensive care station].
367 patients treated on the intensive care unit were prospectively documented during a 1-year observation period. Plasma colloid osmotic pressure (COP) was daily measured. Human albumin therapy was required only in 10% of all patients. These mainly long-term (greater than 10 days) treated patients also showed the lowest levels of COP (minimum COP means: 21 cmH2O (= 15.4 mmHg]. In the majority of all cases an extreme decrease of COP (less than 20 cmH2O (= 14.7 mmHg] was due to sepsis associated with an unfavorable prognosis. 67% of all patients with at least a single decrease of COP less than 20 cmH2O died, as compared to 15% of the patients where the COP never fell below 25 cmH2O. When a low COP was secondary to sepsis, the therapeutic benefit of an albumin therapy could not be evaluated.
Chirurgische Universitätsklinik Köln-Lindenthal.
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R
Grundmann
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Tübergen
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001798:Blood Proteins / Q000378:metabolism*; D002648:Child; D003422:Critical Care; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009997:Osmotic Pressure; D011183:Postoperative Complications / Q000628:therapy*; D011379:Prognosis; D012709:Serum Albumin / Q000008:administration & dosage*; D013530:Surgical Wound Infection / Q000628:therapy
D001798:Blood Proteins; D012709:Serum Albumin
Humanalbumintherapie und prognostischer Wert der kolloid-osmotischen Druckbestimmung auf der chirurgischen Intensivstation.