Interactions of taurine and dopamine in the striatum.
Both spontaneous and K+-stimulated taurine release from rat striatal slices were affected by dopamine and apomorphine, suggesting that dopaminergic systems are able to modulate taurine release. K+-stimulated dopamine release was potentiated by taurine, which effect may not involve dopamine autoreceptors. Taurine was able to inhibit spiperone binding to striatal membranes in a uncompetitive manner and thus interfere with the function of dopaminergic receptors.
Department of Biomedical Sciences, University of Tampere, Finland.
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D000818:Animals; D001692:Biological Transport; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000378:metabolism; D013134:Spiperone / Q000378:metabolism; D013654:Taurine / Q000378:metabolism*
D011985:Receptors, Serotonin; D013654:Taurine; D013134:Spiperone; D011188:Potassium; D004298:Dopamine