[Effect of vagotomy on the duodenal mechanisms regulating gastric secretion].
Gastric acid secretion, gastrin and secretin serum levels after duodenal acidification were studied in 6 dogs, before and after a troncular vagotomy was performed in each one. After duodenal acidification in normal dogs, a 45.2% inhibition of gastric acid secretion with parallel 55-84% increases in the serum secretin levels, without changes in the serum gastrin levels, was noted. When a troncular vagotomy was performed in the same dogs, duodenal acidification produced a 20% (non significant) inhibition of gastric acid secretion with parallel 34-72% increases in the serum secretin levels and without changes in the serum gastrin levels. It is concluded that vagus nerve is necessary to assess a physiological inhibition of gastric secretion after duodenal acidification and it is suggested that humoral and nervous factors are implicated and coexist in these mechanisms.
Servicio de Aparato Digestivo, Hospital Clínico Universtario, Zaragoza, España.
A
A
Lanas
J
J
Alcalde
R
R
García-Cabo
J R
JR
Morandeira
R
R
Sainz
D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000502:physiology*; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D005768:Gastrointestinal Hormones / Q000097:blood*; D010418:Pentagastrin / Q000494:pharmacology; D012633:Secretin / Q000097:blood; D014630:Vagus Nerve / Q000502:physiology*
D005755:Gastrins; D005768:Gastrointestinal Hormones; D012633:Secretin; D010418:Pentagastrin
Efecto de la vagotomía en los mecanismos duodenales que regulan la secreción gástrica.