New macrocyclic trichothecenes from Baccharis megapotamica.
The isolation and structural elucidation of biologically active baccharinoids B1 [11a], B2 [12a], B3 [5a], and B7 [6a] are reported with crystal structure determinations of baccharinoid B7 and of the triacetate of baccharinoid B2. All four compounds are isomeric with 11a/12a and 5a/6a being epimeric at C13'.
Department of Chemistry and Biochemistry, University of Maryland, College Park 20782.
B B
BB
Jarvis
S N
SN
Cömezoğlu
H L
HL
Ammon
C K
CK
Breedlove
R W
RW
Miller
M K
MK
Woode
D R
DR
Streelman
A T
AT
Sneden
R G
RG
Dailey
S M
SM
Kupchan
D001938:Brazil; D055598:Chemical Phenomena; D002621:Chemistry; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000032:analysis*; D012717:Sesquiterpenes / Q000302:isolation & purification*; D014255:Trichothecenes / Q000302:isolation & purification* / Q000494:pharmacology; D014961:X-Ray Diffraction
D012717:Sesquiterpenes; D014255:Trichothecenes