Naloxone elicits dose-dependent changes in alcohol-induced increases in endogenous dopamine release from rat striatum.
These experiments examined the effects of naloxone on alcohol-induced changes in striatal concentrations of DOPAC and HVA, on endogenous dopamine release from striatum in vitro, and on duration of sleep time in vivo. The results emphasize the role of opioid peptides in alcohol's effects on dopaminergic function and on behaviour.
Holman
R B
RB
Dept. of Physiology & Biochemistry, University of Reading, Berks., U.K.
Snape
B M
BM
Widdowson
P S
PS
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000818:Animals; D003342:Corpus Striatum / Q000032:analysis / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006719:Homovanillic Acid / Q000032:analysis; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects
D015102:3,4-Dihydroxyphenylacetic Acid; D009270:Naloxone; D000431:Ethanol; D004298:Dopamine; D006719:Homovanillic Acid