Urinary metabolism of dextromethorphan in man.
After an oral dose of 50 mg of (+)-3-methoxy-N-methylmorphinan (dextromethorphan) to volunteers, urinary metabolism was studied by gas chromatography/mass spectrometry. A total of 15 previously unknown metabolites and derivatives of dextromethorphan could be identified by mass spectrometric techniques. The main metabolic pathways were: O,N-demethylation, O,N-acetylation, hydroxylation of the phenyl ring and the saturated ring system with subsequent further oxidation.
Köppel
C
C
Reanimationszentrum, Klinikum Charlottenburg, Freie Universität Berlin, Germany.
Tenczer
J
J
Ibe
K
K
D000107:Acetylation; D001711:Biotransformation; D003640:Dealkylation; D003915:Dextromethorphan / Q000652:urine*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006900:Hydroxylation; D007981:Levorphanol / Q000031:analogs & derivatives*
D007981:Levorphanol; D003915:Dextromethorphan