Synthesis of amide derivatives of 5,5-diphenylhydantoin as potential antiarrhythmic agents. I.
5,5-Diphenylhydantoin derivatives containing amide groups at the position 3 were synthesized as potential antiarrhythmic agents. The most valuable was (X) whose antiarrhythmic activity is stronger than that of phenytoin.
Kieć-Kononowicz
K
K
Department of Pharmaceutical Chemistry Medical Academy-Kraków, Poland.
Zejc
A
A
Krupińska
J
J
Stypula
E
E
Cebo
B
B
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology; D055598:Chemical Phenomena; D002621:Chemistry; D004562:Electrocardiography; D005260:Female; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D010672:Phenytoin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000889:Anti-Arrhythmia Agents; D010672:Phenytoin