[Migration of the nucleus and cytoplasm along the pseudopodium of the differentiated neuroblastoma cell].
Motility of neuroblastoma cells in the culture of cell line C-1300, clone N-18-A was investigated microcinematographically. In the course of morphological differentiation of the cells, after cytochalasin B treatment (1.8 mkg/ml for 24 hours), in some differentiated cells a special type of movement of the cytoplasmic mass together with the nucleus along elongated pseudopodia was detected. Such a type of movement has never been described. Sometimes, a shift in the nucleus position resulted in the complete change or reversion of cell polarity. The phenomenon of cell nucleus displacement relative to the cell configuration or reversion of the cell polarity can possibly play an important functional role for neural cells.
Ivanova
O Iu
OIu
Domnina
L V
LV
Vasil'ev
Iu M
IuM
Gel'fand
I M
IM
D000818:Animals; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000648:ultrastructure*; D003571:Cytochalasin B / Q000494:pharmacology; D003593:Cytoplasm / Q000187:drug effects / Q000648:ultrastructure*; D051379:Mice; D009447:Neuroblastoma / Q000648:ultrastructure*; D011554:Pseudopodia / Q000187:drug effects / Q000648:ultrastructure*; D014407:Tumor Cells, Cultured
D003571:Cytochalasin B
Migratsiia iadra i tsitoplazmy vdol' udlinennogo otrostka differentsirovannoĭ kletki neĭroblastomy.