Serotonin efflux-inducing effects on human blood platelets by carbamoylpiperidine and nipecotoylpiperazine aggregation inhibitors.
The serotonin efflux-inducing potency of carbamoylpiperidine and nipecotoylpiperazine aggregation inhibitors was evaluated in human blood platelets. Findings were interpreted in terms of structure-activity relationships, and related to actions exerted by the compounds on other human blood platelet functions. Termination of the active efflux period in the presence and absence of acetylsalicylic acid allowed assessment of the influence of aspirin on the quenching process.
Department of Medicinal Chemistry, College of Pharmacy, University of Tennessee, Memphis 38163.
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Lasslo
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Dillingham
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Gollamudi
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Carter-Burks
D001792:Blood Platelets / Q000378:metabolism*; D002219:Carbamates / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009557:Nipecotic Acids / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D012701:Serotonin / Q000097:blood*; D013329:Structure-Activity Relationship
D002219:Carbamates; D009557:Nipecotic Acids; D010879:Piperazines; D010975:Platelet Aggregation Inhibitors; D012701:Serotonin