Glandular cystic hyperplasia of the endometrium in the perimenopausal years.
Fifty patients with simple glandular cystic hyperplasia of the endometrium-GCHE (one with partly adenomatous and two with partly atypical GCHE) were treated with Dabroston through 6 cycles. Daily dosage was 20-30 mg, higher dosage for those with exceeded optimal body weight. After 6 cycles of therapy curettage was repeated in 18 patients and histologic picture of the endometrium was analysed. The post-treatment curettage revealed GCHE in 5 patients, proliferative endometrium in 6 patients and secretory endometrium in 7 patients. In spite of GCHE neurovegetative perimenopausal symptoms were present in 62% before treatment and were even exaggerated in 34% of the patients during the treatment.
E. Kardelj University, Ljubljana.
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H
Meden-Vrtovec
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Hren-Bozic
D000328:Adult; D003560:Cysts / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004394:Dydrogesterone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004714:Endometrial Hyperplasia / Q000188:drug therapy* / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D008593:Menopause; D008595:Menorrhagia / Q000188:drug therapy; D008875:Middle Aged
D004394:Dydrogesterone