111In-labelled baboon platelets: the influence of in vivo redistribution and contaminating 114mIn on the radiation dose.
In five normal baboons, whole body 111In decreased slowly (t1/2 = 60 days) after the end of platelet lifespan. There was slight elution of radioactivity from the liver and spleen, the important sites of platelet sequestration. A fraction of this eluted radioactivity accumulated in the bone marrow, but also in other tissues. This redistribution did not have a significant effect on the measurement of in vivo platelet kinetics. It did however, diminish the total weighted radiation dose, especially that due to contaminating 114mIn.
Blood Platelet Research Unit, South African Medical Research Council, Bloemfontein.
H F
HF
Kotzé
M G
MG
Lötter
A D
AD
Heyns
A
A
Sweetlove
P N
PN
Badenhorst
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism; D004307:Dose-Response Relationship, Radiation; D007204:Indium / Q000097:blood / Q000493:pharmacokinetics*; D007205:Indium Radioisotopes; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D010215:Papio / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
D007205:Indium Radioisotopes; D007204:Indium