Activity of phosphatidylserine on memory retrieval and on exploration in mice.
Recent human and animal studies have reported about neurochemical and behavioral changes occurring during aging. Bovine brain phosphatidylserine (BC-PS) administered in vivo was reported to produce changes in the metabolic status of the brain and in behavioral performances. Within the Albino-Swiss strain of mice two subtypes have been shown to exist with different learning and memory retention abilities. These animals also have different reactions to various psychoactive drugs. The experiments presented here deal with the hypothesis that BC-PS may show different effects according to the starting emotional status of the animals. The technique of intracerebral injection was employed to ensure active concentrations of BC-PS in the brain. The results reported here show that BC-PS clearly improves performances in the subtype of mice with poor exploratory activity.
Instituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
L
L
Valzelli
W
W
Kozak
A
A
Zanotti
G
G
Toffano
D000284:Administration, Oral; D000818:Animals; D003214:Conditioning, Classical; D005106:Exploratory Behavior / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D010718:Phosphatidylserines / Q000008:administration & dosage / Q000494:pharmacology*
D010718:Phosphatidylserines