[Effect of aminoxidase activity regulators on the humoral immune response and proliferation of lymphoid and nonlymphoid cells].
DL-malic acid dibenzylhydrazide (I) and dihydrazide (II), inhibitors of aminoxidases, have been shown to inhibit immune reactions when administered at the phase of initiation but to stimulate the immune response and proliferation of lymphoid and nonlymphoid cells if given on the 2nd and 3rd day following immunization when the immune reaction is in progress. The intensity of local allergic reaction during passive skin anaphylaxis is reduced by I and enhanced by II if the compounds are administered 16 hrs prior to antigen challenge.
Gol'dshteĭn
M M
MM
Dontsov
V I
VI
Baumanis
E A
EA
Lidak
M Iu
MIu
D000707:Anaphylaxis / Q000139:chemically induced / Q000276:immunology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D006168:Guinea Pigs; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D008996:Monoamine Oxidase Inhibitors
Vliianie reguliatorov aktivnost' monoaminoksidaz na gumoral'nyĭ immunnyĭ otvet i proliferatsiiu limfoidnykh i nelimfoidnykh kletok.