The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats.
The increased use of rats for laboratory studies has increased the urgency for a better understanding of their perception of painful or noxious stimuli and the means of obtunding such stimuli. Four different injectable drugs, pentobarbital, fentanyl-droperidol (Innovar-Vet), ketamine-xylazine and ketamine-diazepam, were evaluated in this study. Unlike previous studies in rodents, this study has quantitated noxious stimulus perception following a temporal sequence of observations. Results showed the greatest inhibition of noxious stimulus perception with Innovar-Vet, lesser inhibition with ketamine-xylazine and ketamine-diazepam, and the least obtunding of nociception with pentobarbital. Results of this study also suggested that a spatial orientation, similar to that present in man, exists within the CNS of rats for receipt of noxious stimulation.
Wixson
S K
SK
Department of Comparative Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
White
W J
WJ
Hughes
H C
HC
Marshall
W K
WK
Lang
C M
CM
D000758:Anesthesia / Q000662:veterinary*; D000777:Anesthetics; D000818:Animals; D003975:Diazepam; D004329:Droperidol; D004338:Drug Combinations; D005283:Fentanyl; D007649:Ketamine; D008297:Male; D009458:Neuroleptanalgesia / Q000662:veterinary*; D010146:Pain / Q000503:physiopathology / Q000662:veterinary*; D010147:Pain Measurement / Q000662:veterinary; D010424:Pentobarbital; D010465:Perception; D051381:Rats; D011919:Rats, Inbred Strains; D014991:Xylazine
D000777:Anesthetics; D004338:Drug Combinations; D014991:Xylazine; D007649:Ketamine; C001451:Innovar; D010424:Pentobarbital; D004329:Droperidol; D003975:Diazepam; D005283:Fentanyl