[Induction of flare-ups of chronic progressive polyarthritis in mice after injection of type II homologous collagen].
Immunization by heterologous type II collagen induces in mice a sudden onset of subacute polyarthritis. In order to form a model of auto-immune pathology, we immunized DBA/1 mice with homologous type II collagen extracted from mice xiphoid process; the induced disease corresponds to a progressive chronic polyarthritis with bouts interspersed with remissions, and predominates especially in males. Type II anti-collagen auto-antibodies are found in the serum, with no correlation between the level of mice type II anti-collagen immunoglobulins G and the clinical manifestations of the disease. The histological study demonstrates signs of hyperplastic villous synovitis, with a discrete and infrequent infiltration with mononuclear cells. The model that is obtained is similar to rheumatoid polyarthritis, but also to spondylo-arthropathies.
INSERM U 283, Hôpital Cochin, Paris.
M C
MC
Boissier
X Z
XZ
Feng
A
A
Carlioz
R
R
Roudier
C
C
Fournier
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D001323:Autoantibodies / Q000096:biosynthesis; D003094:Collagen; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D012737:Sex Factors
D001323:Autoantibodies; D003094:Collagen
Induction d'une polyarthrite chronique évoluant par poussées chez la souris après injection de collagène de type II homologue.