Three possible triggers to induce thrombocytopenia in dengue virus infection.
Changes in platelet count by dengue virus-platelet interaction and the participation of anti-DV antibody to such changes were studied in vitro with the aim to investigate a mechanism of how the DV causes prominent thrombocytopenia characteristically seen in DHF. The results obtained showed that: (1) DV antigen attached to human platelets without immune-mediated reaction, (2) a decrease in platelet count was more markedly demonstrated by the binding of anti-DV antibody on the DV antigen associated with platelets than by the binding of the antigen-antibody complex on platelets, (3) a modulation of endothelial cell by the infection of DV to the cell was suggested as one of the causes of the thrombocytopenia.
Department of Physiology, Kobe University School of Medicine, Japan.
Y
Y
Funahara
K
K
Ogawa
N
N
Fujita
Y
Y
Okuno
D000936:Antigen-Antibody Complex / Q000276:immunology; D000937:Antigen-Antibody Reactions; D001792:Blood Platelets / Q000276:immunology; D003715:Dengue / Q000150:complications*; D003716:Dengue Virus / Q000276:immunology; D004727:Endothelium / Q000166:cytology / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D013921:Thrombocytopenia / Q000209:etiology*
D000936:Antigen-Antibody Complex