Diagnosis of amiodarone-iodine-induced thyrotoxicosis(AIIT) associated with severe nonthyroidal illness.
A rare case of amiodarone-iodine-induced thyrotoxicosis (AIIT) associated with nonthyroidal illness is reported. Serum total thyroxine (TT4) and free T4 (FT4) concentrations were elevated and serum TSH was undetectable as frequently observed also in euthyroid amiodarone-treated patients. At variance with common forms of AIIT, serum total triiodothyronine (TT3) was reduced due to low-T3 syndrome. The laboratory diagnosis was made on the basis of elevated free T3 (FT3) levels. Thus, in patients with severe nonthyroidal illness submitted to chronic amiodarone treatment, thyroid status can only be determined by free hormone measurement, particularly FT3 in the case of thyrotoxicosis.
Cattedra di Endocrinologia, University of Cagliari, Italy.
S
S
Balzano
F
F
Sau
L
L
Bartalena
M
M
Ruscazio
A
A
Balestrieri
A
A
Cherchi
E
E
Martino
D000368:Aged; D000638:Amiodarone / Q000009:adverse effects; D003937:Diagnosis, Differential; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis; D007455:Iodine / Q000009:adverse effects; D008297:Male; D012738:Sex Hormone-Binding Globulin / Q000097:blood; D013959:Thyroid Diseases / Q000150:complications; D013960:Thyroid Function Tests / Q000379:methods; D013971:Thyrotoxicosis / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D012738:Sex Hormone-Binding Globulin; D014284:Triiodothyronine; D013972:Thyrotropin; D007455:Iodine; D000638:Amiodarone; D013974:Thyroxine