Enhanced antibody response in retrovirus-infected mice treated with endotoxin or nontoxic polysaccharide derivative.
Friend leukemia virus (FLV) is a retrovirus which causes marked suppression of the immune response of genetically susceptible mice. In the present study the depressed antibody response to sheep erythrocytes by spleen cells from FLV-infected mice was partially reversed by injection of either a bacterial endotoxin or a nontoxic polysaccharide derivative directly into infected mice or by addition to spleen cell cultures from these mice immunized in vitro with sheep red blood cells (SRBC). The endotoxin and PS in a dose-related manner markedly increased the antibody responsiveness of the spleen cells to SRBC. Thus these results indicate that the nontoxic polysaccharide derivative has properties equivalent to the toxic endotoxin in enhancing the antibody responsiveness of FLV-suppressed spleen cells to a T-cell-dependent antigen like SRBC.
Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa 33620.
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H
Friedman
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RC
Butler
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A
Nowotny
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004731:Endotoxins / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology; D005622:Friend murine leukemia virus / Q000276:immunology; D007942:Leukemia, Experimental / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology
D004731:Endotoxins; D011135:Polysaccharides, Bacterial