[Lipid peroxidation in tissues of rats exposed to head-down tilt, exercise or immobilization stress].
Lipid peroxidation in tissues of rats exposed to antiorthostatic hypokinesia (-15 degrees) for 60 days, heavy-load exercise (swimming) and 2-hour immobilization was investigated polarographically. Antiorthostatic hypokinesia produced activation of free-radical lipid peroxidation in skeletal muscles, myocardium and plasma which reached a peak on hypokinesia day 3 and remained elevated by day 60. Exercise and immobilization applied during hypokinesia led to an accumulation of endogenous lipid peroxidation products in skeletal muscles and in the heart, although in a lesser degree. It is postulated that during hypokinesia lipid peroxidation is most probably activated due to the following factors: increased activity of the hormonal component of the sympathicoadrenal system, accumulation of excessive quantities of free fatty acids, and reduced activity of anti-oxidant enzymes.
Zezerov
A E
AE
Ivanova
S M
SM
Ushakov
A S
AS
D000818:Animals; D005609:Free Radicals; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism*; D013550:Swimming
D005609:Free Radicals; D008054:Lipid Peroxides
Perekisnoe okislenie lipidov v tkaniakh krys pri antiortostaticheskoĭ gipokinezii, deĭstvii fizicheskoĭ nagruzki i immobilizatsionnogo stressa.