Fat soluble vitamins and cancer localization associated to an abnormal ketone derivative of D3 vitamin: carcinomedin.
Many investigations suggested relations between fat soluble vitamin levels in blood and incidence of cancer. These studies are concerning both therapeutical efficiency of vitamins intake, seric levels and cancer risk, and the supposed correlation between blood fat soluble vitamin levels and the cancer localization. The purpose of the present study was to investigate whether the alterations of fat soluble vitamin levels (A-vitamin, beta-carotene and alpha-tocopherol) were correlated not only to carcinogenic processes but also to the localizations of their developments. In a former article, we have found that an abnormal ketone derivative of D3 vitamin (1-keto-24-methyl-25-hydroxycholecalciferol) or carcinomedin was present in the serum of all cancer patients and absent in that of healthy control subjects. Serum levels of the four above substances were determined in 1068 subjects suffering from differently localized cancers and in 880 healthy subjects. A statistical multidimensional analysis of data led a separate five groups of cancer types (p less than 0.001). Within each group alterations of vitamin spectra, compared to controls, were identical; between groups they were significantly different. These groups were: anal and intestinal cancer; pancreatic, hepatic, oesophageal and gastric cancer; laryngeal and lung cancer; uro-genital and breast cancer; brain cancer. All these groups are statistically different from the reference one (p less than 0.001). This grouping roughly corresponds to the embryologic origin of affected organs. This suggests that carcinogenesis may alter fat soluble vitamin metabolism, specifically in various forms of cancer, or these alterations of vitamin metabolism are in some way involved in the carcinogenic process.
Institute of Nutrition, Hospital Robert Debré, Amboise, France.
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Rougereau
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Rougereau
D000328:Adult; D001943:Breast Neoplasms / Q000097:blood; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000097:blood; D002338:Carotenoids / Q000097:blood*; D004067:Digestive System Neoplasms / Q000097:blood; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000097:blood; D007822:Laryngeal Neoplasms / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*; D009423:Nervous System Neoplasms / Q000097:blood; D014565:Urogenital Neoplasms / Q000097:blood; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood*; D019207:beta Carotene
D019207:beta Carotene; C052870:carcinomedin; D014801:Vitamin A; D014810:Vitamin E; D002338:Carotenoids; D002117:Calcitriol