The prognostic significance of virus-associated changes in grade 1 cervical intra-epithelial neoplasia.
Virus-associated changes of the cervix uteri were assessed in patients treated for grade 1 cervical intra-epithelial neoplasia (CIN). Of 106 patients evaluated, 67 (63%) had virus-associated changes. The patients were treated without regard to the presence/absence of virus-associated changes. In 26 patients the treatment was unsuccessful (persistence, recurrence, or progression of the neoplasia). The frequency of treatment failure was 33% in patients with, and 10% in patients without virus-associated changes (p less than 0.025). It is recommended that patients with CIN 1 and virus-associated changes should, after initial treatment, be followed-up with increased attention.
Department of Obstetrics and Gynecology, University of Copenhagen, Gentofte Hospital, Hellerup, Denmark.
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P
Bagi
A M
AM
Worning
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M
Nordsten
A
A
Berget
E
E
Badsberg
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D014777:Virus Diseases / Q000150:complications* / Q000175:diagnosis