Quantified EEG, somatosensory evoked potentials and cerebral blood flow in monitoring experimental brain ischemia.
Cerebral ischemic lesions were induced in rabbits through internal carotid artery embolization by means of microspheres. Different models of stroke ranging from single focal cortical lesion to massive bilateral brain edema were reproduced and monitored up to the 24th hour by electroencephalogram (EEG and QEEG), somatosensory evoked potentials (SEPs), cerebral blood flow (CBF), platelet aggregation. The site and extent of the lesions were verified by histological examinations. Results obtained and physiopathological implications are discussed.
Istituto Neurologico C. Mondino, Università di Pavia.
P
P
Bo
V
V
Cosi
G
G
Introzzi
R
R
Scelsi
A
A
Taccola
A
A
Romani
M
M
Patrucco
A
A
Rozza
F
F
Savoldi
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology*; D002341:Carotid Artery Thrombosis / Q000503:physiopathology; D002343:Carotid Artery, Internal / Q000503:physiopathology; D002540:Cerebral Cortex / Q000473:pathology; D002544:Cerebral Infarction / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D003201:Computers; D004569:Electroencephalography / Q000295:instrumentation*; D005073:Evoked Potentials, Somatosensory; D008905:Minicomputers; D010974:Platelet Aggregation; D011817:Rabbits; D012815:Signal Processing, Computer-Assisted