Differentiation of healthy newborns and newborns-at-risk by spectral analysis of heart rate fluctuations and respiratory movements.
Neonatal heart rate and its interaction with respiration were computerized by spectral and coherence analysis (FFT) to differentiate healthy newborns (n = 9) from newborns with mild neonatal risk (n = 20). An increased mean heart rate and decreased total variability have been found in newborns-at-risk. Respiratory Sinus Arrhythmia is diminished in newborns-at-risk possibly caused by an impairment of autonomic brain stem function. Furthermore, Respiratory Sinus Arrhythmia holds a central position in differentiating healthy newborns and newborns-at-risk with and without neurological abnormalities during the first year of life. Respiratory Sinus Arrhythmia is diminished in newborns-at-risk showing these abnormalities. None of the parameters discriminates between the two groups of risk infants. The final prognostic value of our results must be confirmed in further clinical follow-up examinations.
Institute of Pathological Physiology, Friedrich-Schiller-University of Jena, G.D.R.
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M
Rother
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Zwiener
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M
Eiselt
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H
Witte
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G
Zwacka
J
J
Frenzel
D001146:Arrhythmia, Sinus / Q000151:congenital / Q000175:diagnosis; D006339:Heart Rate; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D009422:Nervous System Diseases / Q000151:congenital / Q000175:diagnosis; D012119:Respiration; D012307:Risk Factors; D012890:Sleep