Increased prevalence of apolipoprotein E2 in patients with retinitis pigmentosa.
Apolipoprotein E isoforms were determined in 139 unrelated patients with retinitis pigmentosa (RP). When compared to prevalence rates for the general population in Germany, an increased prevalence was observed for phenotypes E2/E2: 10.1 vs. 1.0% (p less than 0.001), E2/E3: 19.4 vs. 12.0% (p less than 0.05), and E2/E4: 5.8 vs. 1.5% (n.s.), while the prevalence appeared to be reduced for phenotypes E3/E3: 48.9 vs. 59.8% (n.s.) E3/E4: 13.7 vs. 22.9% (p less than 0.05), and E4/E4: 2.2 vs. 2.8% (n.s.). These findings suggest that genetically determined abnormalities of plasma lipoprotein metabolism may be associated with some forms of RP.
Jahn
C E
CE
Department of Ophthalmology and Medicine, University of Bonn, FRG.
Oette
K
K
Esser
A
A
von Bergmann
K
K
Leiss
O
O
D053329:Apolipoprotein E2; D001057:Apolipoproteins E / Q000097:blood* / Q000235:genetics; D006801:Humans; D009994:Osmolar Concentration; D010641:Phenotype; D012174:Retinitis Pigmentosa / Q000097:blood*
D053329:Apolipoprotein E2; D001057:Apolipoproteins E