[Pharmacokinetic, behavioral and neurophysiological aspects of the action of 2-ethyl-6-methyl-3-hydroxypyridine in rats].
Specific features of 2-ethyl-6-methyl-3-hydroxypyridine (3-OP) action were investigated in white rats. A correlation has been established between pharmacokinetic parameters and basic manifestations of psychotropic 3-OP effect. Correlations have been also observed between the level of manifestation of anxiolytic effect and changes in 3-OP concentrations in the rat brain. Electroencephalographic findings of the nootropic effect in sensorimotor cortex correlate with 3-OP brain concentrations. The authors describe specific drug pharmacokinetics and possible mechanisms of realization of psychotropic effects.
Sariev
A K
AK
Krapivin
S V
SV
Voronina
T A
TA
Zherdev
V P
VP
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D003220:Conflict, Psychological; D004569:Electroencephalography / Q000379:methods; D004594:Electrophysiology; D008099:Liver / Q000378:metabolism; D008297:Male; D010847:Picolines / Q000493:pharmacokinetics* / Q000494:pharmacology; D010949:Plasma / Q000378:metabolism; D011619:Psychotropic Drugs / Q000493:pharmacokinetics* / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D010847:Picolines; D011619:Psychotropic Drugs; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Farmakokineticheskie, povedencheskie i neĭrofiziologicheskie aspekty deĭstviia 2-étil-6-metil-3-oksipiridina u krys.