Mugineic acid: non-selective enhancement of excitatory amino acid actions on rat central neurones.
The effects of mugineic acid upon excitations induced by quisqualic acid (quis), N-methyl-D-aspartic acid (NMDA) and kainic acid (kain) on rat central neurones were examined in vivo through microiontophoretic drug administration in anaesthetized rats. Mugineic acid usually caused a non-selective enhancement of drug-induced excitations, occasionally producing direct excitation itself or increasing the rate of spontaneous discharge. Mugineic acid-induced effects were not blocked by the NMDA selective antagonist, 2-amino-5-phosphonovaleric acid (AP5).
Kaneko
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Department of Medical Physiology, Faculty of Medicine, University of Calgary, Alberta, Canada.
Hicks
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TP
Bauce
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D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001383:Azetidinecarboxylic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D001385:Azetines / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010944:Plants / Q000032:analysis; D051381:Rats; D013268:Stimulation, Chemical
D000596:Amino Acids; D001385:Azetines; D001383:Azetidinecarboxylic Acid; C052863:mugineic acid