Water-suppressed volume-selected 1H NMR spectroscopy in vivo: application to study tumor metabolism.
Volume selection using SPACE has been combined with water suppression techniques to provide high-resolution 1H NMR spectra from aqueous solutions. The technique developed was used to obtain spectra from a tumor growing on the hind leg of a rat. Water suppression factors of between 1000 and 2000 were achieved simultaneously with excellent volume selection.
Haseler
L J
LJ
School of Science, Griffith University, Nathan, Australia.
Galloway
G J
GJ
Field
J
J
Irving
M G
MG
Doddrell
D M
DM
D000230:Adenocarcinoma / Q000378:metabolism*; D000818:Animals; D001834:Body Water; D000431:Ethanol / Q000032:analysis; D006614:Hindlimb; D050356:Lipid Metabolism; D009682:Magnetic Resonance Spectroscopy; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013057:Spectrum Analysis; D014867:Water
D014867:Water; D000431:Ethanol