Evaluation of clorsulon against immature Fascioloides magna in cattle and sheep.
Efficacy of clorsulon was evaluated against infection with immature Fascioloides magna in 24 cattle and 12 sheep. Infections were induced by oral administration of 600 metacercariae/host. In cattle, clorsulon at dosages of 7 and 21 mg/kg of body weight was 65 and 100% effective against 8-week-old flukes, and 20 and 74% effective against 16-week-old flukes, respectively. In sheep, clorsulon at a dosage of 21 mg/kg was 92% effective against 8-week-old flukes. Significantly (P less than 0.05) more F magna were recovered from untreated sheep than from untreated cattle.
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164.
W J
WJ
Foreyt
D000818:Animals; D000980:Antiplatyhelmintic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology; D005212:Fasciolidae / Q000187:drug effects*; D005213:Fascioloidiasis / Q000188:drug therapy* / Q000469:parasitology; D007814:Larva / Q000187:drug effects; D008297:Male; D012756:Sheep / Q000469:parasitology; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology; D013424:Sulfanilamides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D000980:Antiplatyhelmintic Agents; D013424:Sulfanilamides; C015675:clorsulon