Post-coital antifertility activity of the seeds of Coriandrum sativum in rats.
Effect of the aqueous extract of fresh coriander (Coriandrum sativum) seeds has been studied on female fertility in rats. Parameters included effects on oestrus cycle, implantation, foetal loss, abortion, teratogenicity and serum progesterone levels on days 5, 12 and 20 of the pregnancy. The extract at doses of 250 and 500 mg/kg orally produced a dose-dependent significant anti-implantation effect, but failed to produce complete infertility. Treatment of animals during day-8 to day-12 and day-12 to day-20 of the pregnancy did not produce any significant abortifacient activity. There was no significant change in the weight and length of the foetuses delivered by rats treated with the extract and no abnormalities were seen in the organs of the offsprings. The extracts produced a significant decrease in serum progesterone levels on day-5 of pregnancy which may be responsible for the anti-implantation effect observed in this study.
Al-Said
M S
MS
Research Centre, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Al-Khamis
K I
KI
Islam
M W
MW
Parmar
N S
NS
Tariq
M
M
Ageel
A M
AM
D000019:Abortifacient Agents; D000818:Animals; D003281:Contraceptives, Postcoital; D010064:Embryo Implantation / Q000187:drug effects; D004971:Estrus / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000187:drug effects / Q000473:pathology
D000019:Abortifacient Agents; D003281:Contraceptives, Postcoital; D010936:Plant Extracts; D011374:Progesterone