[Genetic factors predisposing to autoimmune diseases. Study of HLA antigens in a family with pernicious anemia and thyroid diseases].
In a family including patients suffering from autoimmune disease (2 propositi: pernicious anemia and Graves' disease, pernicious anemia and autoimmune thyroiditis), we have determined common autoantibodies and tissue antigens (HLA) in 47 patients (26 males and 21 females) from 2 generations. In this family, we have found 4 cases of pernicious anemia, 5 cases of thyroid disease (2 Graves' disease), 3 women with repetitive abortions and 2 cases of melanoma. Patients with autoantibodies, often asymptomatic, are abnormally numerous (44% in generation II, 16% in generation III). A correlation with haplotype A1B8DR3 was found only for Graves' disease. Likelihood of forming autoantibodies appears to be of multifactorial origin. Its mode of transmission remains unknown.
Service de médecine, Hôpital régional, Martigny.
J
J
Petite
N
N
Rosset
B
B
Chapuis
M
M
Jeannet
D000026:Abortion, Habitual / Q000235:genetics; D000328:Adult; D000368:Aged; D000752:Anemia, Pernicious / Q000235:genetics* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000235:genetics*; D002648:Child; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000145:classification; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics; D008875:Middle Aged; D010375:Pedigree; D011247:Pregnancy; D013959:Thyroid Diseases / Q000235:genetics* / Q000276:immunology
D001323:Autoantibodies; D006680:HLA Antigens
Facteurs génétiques prédisposant aux maladies auto-immunes. Etude des antigènes HLA dans une famille avec anémie pernicieuse et maladies thyroïdiennes.