[Immunoreactive systems in the healing of aseptic and infected wounds in an experiment].
Main parameters of systemic immune reactivity were studied in 240 mature Wistar male rats with simulated aseptic and infected surface wounds before surgical intervention, and 1-10, 12 and 15 days after it. It was stated that aseptic wounds were responsible for nonspecific systemic response to the stress, whereas the presence of bacterial flora in the wound inhibited the development of humoral immune response in the presence of T-cell activation thus causing the dysfunction of the immune system and therefore affecting the course of wound progress. The consideration of all factors mentioned permits averting wound purulent complications in postsurgical period.
Nikolaev
A V
AV
Mamedov
L A
LA
Zakharov
V V
VV
Belokrinitskiĭ
D V
DV
Kudriavitskiĭ
A I
AI
D000818:Animals; D001207:Asepsis; D007107:Immune System / Q000276:immunology*; D007111:Immunity, Cellular; D007113:Immunity, Innate; D008297:Male; D010587:Phagocytosis; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014945:Wound Healing; D014946:Wound Infection / Q000276:immunology*; D014947:Wounds and Injuries / Q000276:immunology*
Sostoianie immunoreaktivnykh sistem pri zazhivlenii asepticheskikh i infitsirovannykh ran v éksperimente.