[The possibility of targeted pharmacological action on the intravascular binding of calcium ions: a new aspect of pharmacodynamics?].
The administration of cardiac glycosides (digoxin, strophanthin, corglycon) invariably produced a calcium ionizing effect raising the content of blood serum ionized calcium and a degree of serum calcium ionization. Calcium transport antagonists (verapamil, nifedipine) made a reverse effect (a calcium-binding effect). Both effects were noted 5-15 min, after administration of the drugs disappearing in 60-90 min. They were reproduced after adding digoxin, strophanthin and verapamil to the blood serum in vitro but they were not summarized and probably did not depend on a basal level of calcemia. Under the influence of digoxin blood serum calcium binding capacity was on a regular decrease whereas under the influence of verapamil and nifedipine it was on an increase. Close negative correlation was found between shifts of blood serum calcium binding capacity and a degree of serum calcium ionization.
V V
VV
Kolomiets
K A
KA
Merzon
D002118:Calcium / Q000097:blood*; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002135:Calcium-Binding Proteins / Q000097:blood; D002301:Cardiac Glycosides / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002908:Chronic Disease; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy; D006801:Humans; D066298:In Vitro Techniques; D011485:Protein Binding / Q000187:drug effects; D012214:Rheumatic Heart Disease / Q000097:blood / Q000188:drug therapy; D013997:Time Factors
D002121:Calcium Channel Blockers; D002135:Calcium-Binding Proteins; D002301:Cardiac Glycosides; D002118:Calcium
O vozmozhnosti napravlennogo farmakologicheskogo vozdeĭstviia na vnutrisosudistoe sviazyvanie ionov kal'tsiia: novyĭ aspekt farmakodinamiki?