Cefonicid concentration in lung tissue after intramuscular administration.
A long-acting cephalosporin, cefonicid, was given as a single 1 g dose to sixteen patients hospitalized for lung carcinoma and undergoing thoracic surgery. Lung and serum specimens were obtained approximately 2, 4, 6 and 12 h after injection. Antibiotic assay was made by means of a microbiological method. Effective concentrations of cefonicid in the serum and lung tissue were achieved during the sampling time (12 h). The data suggest that a single dose of cefonicid may be useful for antibiotic prophylaxis in thoracic surgery.
Institute of Infectious Diseases, University of Pavia, Italy.
M
M
Cruciani
S
S
Savio
E
E
Concia
D002435:Cefamandole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D015790:Cefonicid; D006801:Humans; D007273:Injections, Intramuscular; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D002435:Cefamandole; D015790:Cefonicid