Distal small bowel resection does not modify the intestinal 3-hydroxy-3-methylglutaryl CoA reductase activity.
The activity of 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMG-CoA red.) has been evaluated in rat jejunal, caecal and colonic mucosa adapting to 50% or 75% distal small bowel resection (SBR). Six wk after surgery, the total activity and the activity state (active form) of the enzyme were determined. The results show that HMG-CoA red. activity was stimulated per organ but not per unit mass in the mucosa adapting to SBR. As a side result, we noted regional differences in the active/total reductase ratio (RA/RT) for HMG-CoA red. that was lower in small intestine compared with that of the large intestine.
Molina
M T
MT
Departamento de Fisiologia Animal, Facultad de Farmacia, Universidad de Sevilla, Spain.
Vazquez
C M
CM
D000818:Animals; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000032:analysis / Q000201:enzymology; D007421:Intestine, Small / Q000201:enzymology* / Q000601:surgery; D008297:Male; D011506:Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D011506:Proteins; D006903:Hydroxymethylglutaryl CoA Reductases