Pregnancies of mothers with a neural tube defect child: outcomes and recurrence risks.
Ninety-four mothers who had been in contact with the Center for Human Genetics of the University of Leuven (Belgium) after the birth of a child with neural tube defect were questioned about the outcomes of their pregnancies. To this end a structured interview and a mailed questionnaire were used. The recurrence rate for neural tube defects after the birth of one affected child was 2.9%. This number is at the lower border of the risk rates (between 3% and 5%) generally given to parents during genetic counseling sessions. The relative amount of miscarriages was larger in the interviewed group than in the Belgian population in general.
Swerts
A
A
Center for Human Genetics, University of Leuven.
Evers-Kiebooms
G
G
Van den Berghe
H
H
D000022:Abortion, Spontaneous; D001530:Belgium; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009436:Neural Tube Defects / Q000453:epidemiology* / Q000235:genetics; D011247:Pregnancy; D011256:Pregnancy Outcome; D012307:Risk Factors