[Pathogenesis of dilated cardiomyopathy: a study based on comparison of the clinical features with other related conditions].
To investigate the pathogenesis and pathophysiology of dilated cardiomyopathy (DCM), we studied 28 patients with DCM by echocardiography and endomyocardial biopsy, and compared their findings with those of 34 patients including eight with myocarditis, seven with alcoholics, 12 with hypertensives and seven patients with hypertrophic cardiomyopathy. All 12 patients in the hypertensive group had congestive heart failure without accompanying high blood pressure, and prominent dilatation and uniform wall motion abnormality of the left ventricle observed echocardiographically on admission. After medical management, both heart failure and the echocardiographic abnormalities gradually resolved. Those in the alcoholic group had larger left ventricles and uniform wall motion abnormality compared to those in the other groups. The myocarditis and hypertrophic cardiomyopathy groups had smaller left ventricles, non-uniform wall motion and larger % myocardial fibrosis. Both ventricles in the hypertrophic cardiomyopathy group were thicker than those of the other three groups. Each patient with DCM had individual echocardiographic abnormalities, which could be categorized as two subsets depending on the degree of left ventricular dilatation and uniformity of the wall motion. The one was characterized by a prominently dilated left ventricle and uniform wall motion abnormality similar to the alcoholic group, and the other had less marked left ventricular dilatation and heterogeneous wall motion abnormality similar to the myocarditis group. From these findings, it was suggested that there are common factors to specific myocardial disease in the pathogenesis and pathophysiology of DCM, and thus, DCM might include many subsets of different etiologies.
Takarada
A
A
First Department of Internal Medicine, Kobe University School of Medicine.
Yokota
Y
Y
Seo
T
T
Maehashi
N
N
Kubo
M
M
Nakanishi
O
O
Teng
S S
SS
Masuda
J
J
Fukuzaki
H
H
D000328:Adult; D000437:Alcoholism; D002311:Cardiomyopathy, Dilated / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D002312:Cardiomyopathy, Hypertrophic; D004452:Echocardiography; D004562:Electrocardiography; D004699:Endocardium / Q000473:pathology; D006801:Humans; D006973:Hypertension; D008875:Middle Aged; D009205:Myocarditis