The effect of pregnancy on disease development and mortality in B/W F1 mice.
Pregnancy was encouraged in 15 B/W mice (Group 1) and the rate of development of FANA, anti-DNA antibodies, and proteinuria compared with that seen in 15 control mice (Group 2). The mean number of pregnancies for Group 1 mice was 5.2. No difference was seen in mortality rate or in the onset of serologic or urinary abnormalities between the 2 groups.
Rheumatic Disease Unit, University of Alberta, Edmonton, Canada.
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Johnston
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Russell
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008180:Lupus Erythematosus, Systemic / Q000401:mortality*; D051379:Mice; D008814:Mice, Inbred NZB; D011247:Pregnancy; D011248:Pregnancy Complications / Q000401:mortality*; D012307:Risk Factors