Reproductive failure and pericentric inversion in man.
Pachytene analysis was carried out on an infertile man heterozygous for a pericentric inversion of chromosome 6. The synaptic behavior of the bivalent 6 inversion was analyzed using electron microscopy in silver stained surface microspread of the inversion-bearing spermatocytes. Possible mechanisms of the sterilizing effect caused by the autosomal inversion are discussed.
Institut d'Embryologie, Faculté de Médecine, Strasbourg, France.
O
O
Gabriel-Robez
C
C
Ratomponirina
M
M
Croquette
J L
JL
Maetz
J
J
Couturier
Y
Y
Rumpler
D000328:Adult; D007446:Chromosome Inversion; D002896:Chromosomes, Human, Pair 6 / Q000648:ultrastructure; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008854:Microscopy, Electron / Q000379:methods; D013094:Spermatozoa / Q000648:ultrastructure