Arterial deepvenous difference of lipoproteins in skeletal muscle of patients in postoperative state: effects of medium chain triglyceride emulsion.
The effect of fat infusion with medium chain triglycerides (MCT) and long chain triglycerides (LCT) on serum lipoproteins before and after passage through the skeletal muscle was investigated with the forearm technic in eight patients after abdominal operation. All lipoprotein fractions were enriched with triglycerides and phospholipids from infused artificial fat particles with the consequence of significantly increased ratios of TG/PL and TG/apo B in VLDL, of TG/apo B in LDL and TG/apo A-I in HDL. Uptake and release of lipoprotein components by skeletal muscle are given by arterial-deepvenous differences considering the blood flow rates. The positive arterial-deepvenous difference of VLDL triglycerides after 4-hr infusion is interpreted as cleavage and uptake of infused MCT by the muscle. The release of LDL is more pronounced after the fat infusion than before, suggesting a degradation and enhanced catabolism of artificial fat particles. HDL release may be also a consequence of catabolism of artificial TG/PL-particles. These results indicate an uptake of MCT/LCT emulsion by the skeletal muscle.
Institut for Nutrition Science, Technical University Munich-Weihenstephan, Freising, Federal Republic of Germany.
S
S
Hailer
K W
KW
Jauch
B
B
Günther
G
G
Wolfram
N
N
Zöllner
G
G
Heberer
D000328:Adult; D001158:Arteries; D005217:Fat Emulsions, Intravenous / Q000493:pharmacokinetics*; D006801:Humans; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000098:blood supply / Q000378:metabolism*; D011184:Postoperative Period; D013514:Surgical Procedures, Operative; D014280:Triglycerides / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*
D005217:Fat Emulsions, Intravenous; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C030106:very low density lipoprotein triglyceride