Effects of ultraviolet light irradiation on the skin of MRL/l mice.
MRL/Mp-lpr/lpr (MRL/l) and MRL/Mp-+/+ mice were irradiated with middle-wavelength ultraviolet light (UVB), and the development of skin lesions, skin lupus band test (LBT), anti-DNA antibodies in sera, and the extent of glomerulonephritis of the kidney were examined. Long-term exposure to low doses of UVB irradiation accelerated the development of skin lesions and enhanced the intensity of the positive skin lupus band in MRL/l mice. The contents of anti-DNA antibodies in sera, the incidence of positive findings in LBT, and the extent of glomerulonephritis were not influenced by the UVB irradiation. The promotion of the development of the skin lesions in MRL/l mice by the UVB exposure was not considered to be associated with acceleration of systemic autoimmune phenomena.
Department of Dermatology, Faculty of Medicine, Kyoto University, Japan.
Y
Y
Horiguchi
F
F
Furukawa
G
G
Ohshio
T
T
Horio
S
S
Imamura
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D004247:DNA / Q000276:immunology; D004307:Dose-Response Relationship, Radiation; D051379:Mice; D008817:Mice, Mutant Strains / Q000276:immunology*; D012867:Skin / Q000473:pathology / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*
D001323:Autoantibodies; D004247:DNA