[Evaluation of the damaging and transforming effect of sodium nitrite on cultured lung cells].
The toxic and transformation actions of sodium nitrite (NN) were studied on the primary lung cell cultures of 3-day old noninbred rats. The monolayer density, mitotic index, DNA-synthetizing activity of cells, frequency of pathological mitoses changes in the character of growth, appearance of the multilayer growth foci serve as a criteria for evaluation. It is established that sodium nitrite has a transforming effect on lung cells and that the concentration of 1.035 mg/ml of nutrient medium is a transforming dose at 48 h exposition. Summation of the effect by prolongation of cell exposition with the NN prethreshold doses is possible.
Osin'kovskaia
N D
ND
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D002478:Cells, Cultured; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008938:Mitosis / Q000187:drug effects; D009573:Nitrites / Q000633:toxicity*; D051381:Rats; D012977:Sodium Nitrite / Q000633:toxicity*
D009573:Nitrites; D012977:Sodium Nitrite
Otsenka povrezhdaiushchego i transformiruiushchego deĭstviia nitrita natriia na kletki legkikh v kul'ture.