Effects of corticosterone on hippocampal slice electrophysiology in normal and adrenalectomized BALB/c mice.
Modulation of CA1 electrophysiological properties (amplitude, latency, paired-pulse facilitation) by different concentrations of corticosterone (CT) was studied in hippocampal slice preparations from normal (sham) and adrenalectomized (ADX) BALB/c mice. In the sham group, CT effects on the population spike (PS) amplitude were biphasic: at a low dose (200 pM) CT induced a delayed increase; at a moderate dose (2,000 pM), a rapid and partially reversible decrease was observed, and at higher doses (5,000 and 10,000 pM) this decrease was more pronounced after 30 min of washout. Diminution of latency and paired-pulse facilitation were obtained for the CT concentration inducing an increase of the PS amplitude. In the ADX group, similar CT effects were observed for lower doses: a decrease of the PS amplitude was observed for 40 and 100 pM and an increase for 5 pM, but variations of the PS amplitude were weaker than in the sham group. The role of the different CT receptor systems in this neuromodulatory effect is discussed.
Department of Behavioral Neurobiology, UA CNRS 372, University of Provence, Marseilles, France.
M
M
Rey
E
E
Carlier
B
B
Soumireu-Mourat
D000315:Adrenalectomy; D000818:Animals; D003345:Corticosterone / Q000008:administration & dosage / Q000494:pharmacology*; D004594:Electrophysiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C
D003345:Corticosterone