Different biochemical composition of connective tissue in continent and stress incontinent women.
The collagen content in biopsies from skin and ligamentum rotundum of 7 women with a long history of stress incontinence was compared with that of continent controls. The collagen was extracted with 0.5 M acetic acid, followed by digestion with pepsin and quantitated as hydroxyproline. The skin of stress incontinent women contained 40% less collagen than that of continent women. The findings for ligamentum rotundum were similar. These results suggest a deteriorated connective tissue in stress-incontinent women and cast new light on the etiology of the disease.
Department of Obstetrics and Gynecology, Akademiska sjukhuset, Uppsala, Sweden.
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Ulmsten
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Ekman
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Giertz
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Malmström
D000328:Adult; D003094:Collagen / Q000378:metabolism; D003238:Connective Tissue / Q000473:pathology*; D005260:Female; D006801:Humans; D008022:Ligaments / Q000378:metabolism; D008875:Middle Aged; D012867:Skin / Q000378:metabolism; D014550:Urinary Incontinence, Stress / Q000209:etiology / Q000473:pathology*; D014553:Urinary Tract Physiological Phenomena
D003094:Collagen