Ethanol-induced oxidative stress in the rat cerebellum.
An acute ethanol load (50 mmol/kg, i.p.) produces an increase in lipid peroxidation in the rat cerebellum. The levels of ascorbate and alpha-tocopherol, which represent efficient antioxidants acting synergetically, are decreased. This decrease seems highly indicative of a consumption of the antioxidants in quenching free radicals and suggests that acute ethanol induces an oxidative stress at the cerebellar level. As allopurinol, a xanthine oxidase inhibitor, prevents the decrease in alpha-tocopherol, xanthine oxidase may contribute to this oxidative stress.
Department of Biomedical Research on Alcoholism, University Paris V, France.
H
H
Rouach
M K
MK
Park
M T
MT
Orfanelli
B
B
Janvier
R
R
Nordmann
D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis; D002531:Cerebellum / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000032:analysis; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000032:analysis
D008054:Lipid Peroxides; D014810:Vitamin E; D000431:Ethanol; D000493:Allopurinol; D001205:Ascorbic Acid