The allergens in cosmetics.
The ingredients responsible for allergy to cosmetics were determined in 119 patients suffering from cosmetic-related contact dermatitis. Most reactions (56.3%) were caused by skin care products, followed by nail cosmetics (13.4%), perfumes (8.4%), and hair cosmetics (5.9%). Preservatives were most frequently implicated (32.0%), followed by fragrances (26.5%) and emulsifiers (14.3%). By far the most important cosmetic allergen was Kathon CG, (a preservative system containing, as active ingredients, a mixture of methylisothiazolinone and methyl chloroisothiazolinone) reacting in 33 patients (27.7%). Other frequent causes of cosmetic-related contact allergic reactions were toluenesulfonamide/formaldehyde resin in nail hardener and/or nail lacquer (15 patients [12.6%]), and oleamidopropyl dimethylamine, an emulsifier in baby body lotion (13 patients [10.9%]).
de Groot
A C
AC
Department of Dermatology, Carolus and Willem-Alexander Hospital, 's-Hertogenbosch, The Netherlands.
Bruynzeel
D P
DP
Bos
J D
JD
van der Meeren
H L
HL
van Joost
T
T
Jagtman
B A
BA
Weyland
J W
JW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000633:toxicity*; D002648:Child; D003358:Cosmetics / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D012189:Retrospective Studies
D000485:Allergens; D003358:Cosmetics