Effects of D-glucose, 2-deoxy-D-glucose and D-xylose on renal function in the rat.
1. Standard renal clearance techniques were used to investigate the effects of 2.5, 5 and 10% D-glucose, 2.5% 2-deoxy-D-glucose and 2.5% D-xylose on kidney function in male rats. 2. There was no consistent effect of D-glucose on urinary sodium output except with 10% D-glucose, where sodium excretion was raised compared to controls. 3. An increased urinary calcium output was seen in all D-glucose-infused rats compared to controls. Values obtained for 2.5, 5 and 10% glucose were respectively 32, 61 and 58% above control data. Neither 2-deoxy-D-glucose nor D-xylose produced a calciuresis. 4. The increased urinary calcium excretion in D-glucose rats was the result of a reduction in fractional calcium reabsorption. Glomerular filtration rate (GFR) was unchanged. It was not dependent upon glycosuria or a diuresis.
Department of Physiological Sciences, University of Manchester.
H O
HO
Garland
H J
HJ
Singh
D000042:Absorption; D000818:Animals; D002118:Calcium / Q000652:urine; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine; D013268:Stimulation, Chemical; D014556:Urine; D014994:Xylose / Q000494:pharmacology*
D003837:Deoxy Sugars; D003847:Deoxyglucose; D012964:Sodium; D014994:Xylose; D005947:Glucose; D002118:Calcium