[Thrombocyte lysosomal hydrolase activity in patients with ischemic heart disease, hyperlipidemia and obesity against a background of different diets].
Investigation of lysosomal hydrolase activity in platelets of patients has revealed drastic activation of cathepsins B, C and phospholipase A1, the degree of which rose in the following range: coronary heart disease; coronary heart disease aggravated by obesity: obesity and hyperlipidemia (type II). Administration of the adequate dietotherapy resulted in normalization of enzymologic parameters, whereas the results of the clinico-biochemical analysis of the blood were less informative in all cases. The data obtained could be used in the evaluation of the dietotherapy effectiveness, as well as for the early diagnosis of the corresponding diseases.
A V
AV
Vasil'ev
N P
NP
Shimanovskaia
A V
AV
Pogozheva
M A
MA
Samsonov
V A
VA
Tutel'ian
D000328:Adult; D001792:Blood Platelets / Q000201:enzymology*; D002403:Cathepsins / Q000097:blood; D003327:Coronary Disease / Q000178:diet therapy / Q000201:enzymology*; D004038:Diet, Reducing; D006801:Humans; D006867:Hydrolases / Q000097:blood*; D006949:Hyperlipidemias / Q000178:diet therapy / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology*; D008875:Middle Aged; D009747:Nutritional Physiological Phenomena; D009765:Obesity / Q000178:diet therapy / Q000201:enzymology*; D010740:Phospholipases / Q000097:blood
D006867:Hydrolases; D010740:Phospholipases; D002403:Cathepsins
Aktivnost' lizosomal'nykh gidrolaz trombotsitov u bol'nykh ishemicheskoĭ bolezn'iu serdtsa, giperlipidemieĭ i ozhireniem na fone razlichnogo pitaniia.