[Dynamics of carrageenin-induced inflammation after use of lithium oxybutyrate].
Lithium hydroxybutyrate (200 mg/kg) has been shown to depress the development of carrageenan inflammation. Subcutaneous drug injection in chronic inflammation of the mucous membrane in the hamster cheek pouch restored the blood flow, checked dilatation of the blood vessels, decreased their permeability and prevented necrosis of the mucous membranes. Subcutaneous drug injection depressed all the signs of both phases of acute inflammatory reaction in the rat hind foot and promoted preservation of the hind foot function. Therefore, lithium hydroxybutyrate may be an effective preparation for the treatment of inflammation.
P N
PN
Aleksandrov
T V
TV
Speranskaia
D000818:Animals; D002351:Carrageenan; D002610:Cheek; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008647:Mesocricetus; D008833:Microcirculation / Q000187:drug effects; D009061:Mouth Mucosa / Q000098:blood supply / Q000187:drug effects; D009942:Organometallic Compounds / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; C022826:lithium hydroxybutyrate; D002351:Carrageenan
Dinamika karrageninovogo vospaleniia v usloviiakh primeneniia oksibutirata litiia.