Myopathy during amiodarone treatment: a case report.
The case of a 69-year-old woman who developed muscle weakness on chronic amiodarone treatment is reported. Muscle biopsy showed vacuolar alterations and a marked accumulation of amiodarone and of its metabolite desethylamiodarone was found in the muscle sample despite normal blood levels. Amiodarone-induced morphological alterations of the muscle may be related to the actual tissue concentration rather than to the blood level.
Clinica Neurologica Ospedale L. Sacco-Milano.
F
F
Carella
E
E
Riva
L
L
Morandi
E
E
Cappiello
A
A
Mangoni
D000368:Aged; D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001706:Biopsy; D004576:Electromyography; D005260:Female; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D009132:Muscles / Q000473:pathology; D009468:Neuromuscular Diseases / Q000139:chemically induced* / Q000473:pathology
D000638:Amiodarone