[The state of calcium homeostasis in the blood in patients with psoriasis during a period of enhanced epidermopoiesis].
As a model of generalized impairments of the membrane structure in patients with psoriasis, an "erythrocyte-blood plasma" system was used for studies of calcium homeostasis. Distinct accumulation of Ca2+ in erythrocytes and reduction of Ca2+ content in blood plasma were observed in patients with psoriasis, thus demonstrating its redistribution between cells and medium. This Ca2+ transfer occurred due to an increase of Na+ concentration in the cells, which caused a decrease in the rate of Ca2+ excretion and led to elevation of the ion content in cytoplasmic fraction. The elevated intracellular concentration of Ca2+ in patients with psoriasis contributed to activation of lipid peroxidation as well as to selective increase in permeability of erythrocyte membranes for K+. The data obtained suggest that a number of alterations in homeostasis of calcium may be considered among the factors responsible for activation of cellular proliferation in the patients with psoriasis.
Goncharenko
M S
MS
Kondakova
A K
AK
Brodskaia
O M
OM
D000208:Acute Disease; D000328:Adult; D002118:Calcium / Q000097:blood*; D002455:Cell Division; D004817:Epidermis / Q000473:pathology*; D004912:Erythrocytes / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000473:pathology
D002118:Calcium
Sostoianie kal'tsievogo gomeostaza krovi u bol'nykh psoriazom v period usilennogo épidermopoéza.