[Synthesis and platelet aggregating activity of structural analogs of platelet-activating factor with a heterocyclic head group].
Structural analogues of platelet-activating factor (PAF, 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine) containing an imidazole or thiazole residue as polar head group have been prepared and tested for platelet aggregating properties. Compared with PAF all analogues exert considerably lower platelet-stimulating activities. The agonistic behaviour is shown to depend primary on the presence of a positively charged polar head group.
Sektion Biowissenschaften, Karl-Marx-Universität Leipzig.
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Kertscher
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Ostermann
D000818:Animals; D001779:Blood Coagulation Factors / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D010972:Platelet Activating Factor; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits
D001779:Blood Coagulation Factors; D006571:Heterocyclic Compounds; D010972:Platelet Activating Factor
Zur Synthese und thrombozytenaggregierenden Wirkung von Strukturanaloga des Plättchenaktivierenden Faktors mit heterocyclischer Kopfgruppe.