Influence of intracerebroventricularly and intracisternally administered vasopressin on the hypothalamic self-stimulation rate of the rat.
Lysine-vasopressin (LVP) at different concentrations (2 ng, 200 pg) was injected into the lateral ventricle and cisterna magna. The effect on hypothalamic self-stimulation was studied in rats. LVP (2 ng) decreased the self-stimulation rate after intracerebroventricular and cisternal application. Injection of 200 pg LVP diminished the self-stimulation rate after cisternal administration only. The findings suggest that the site of peptide administration is of decisive importance to vasopressin-induced effects. Both biochemical factors and the interaction between behaviour and vegetative nervous system should be taken into consideration when interpreting changes in self-stimulation as induced by vasopressin applied to the CSF space.
Günther
O
O
Institute of Physiology, Medical Academy, Magdeburg, German Democratic Republic.
Schwarzberg
H
H
D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D002946:Cisterna Magna / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D007276:Injections, Intraventricular; D008236:Lypressin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation
D008236:Lypressin