[Thromboxane A2 antagonistic effect of antiangina drugs, with special reference to trapidil and trapidil derivatives].
In isolated perfused guinea pig hearts and in the cardiocirculatory system of anaesthetized rabbits the thromboxane A2-agonist U 46619 shows cardiodepressive effects. The contraction force of isolated auricle preparations from guinea pigs was enhanced. Antianginous drugs (dipyridamole, propranolol, verapamil, nitroglycerin and trapidil) induced a significant inhibition of the U 46619 effects. Oxyfedrine remained ineffective. The efficiency of some derivatives of trapidil was markedly diminished or abolished in comparison with the original substance. Because of the different chemical structure of the active drugs the TXA2-antagonism is regarded to be caused by a functional influence on the cellular membrane and the calcium transport. Nevertheless the inhibition of the TXA2-effects by antianginous drugs seems to be a factor for the therapeutic use of these substances.
Mentz
P
P
Institut für Pharmakologie und Toxikologie, Martin-Luther-Universität Halle-Wittenberg.
Pawelsky
K E
KE
Giessler
C
C
Mest
H J
HJ
D000758:Anesthesia; D000787:Angina Pectoris / Q000188:drug therapy*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology*; D003331:Coronary Vessels / Q000187:drug effects; D004176:Dipyridamole / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D011743:Pyrimidines / Q000494:pharmacology*; D011817:Rabbits; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors*; D014192:Trapidil / Q000031:analogs & derivatives / Q000494:pharmacology*
D000889:Anti-Arrhythmia Agents; D002317:Cardiovascular Agents; D011743:Pyrimidines; D013928:Thromboxane A2; D004176:Dipyridamole; D014192:Trapidil
Thromboxan A2-antagonistische Wirkung von antiaginösen Pharmaka unter besonderer Berücksichtigung von Trapidil und Trapidilderivaten.