Comparative metabolism of oestrone sulphate after oral and intravenous administration in post-menopausal women.
Oestrone sulphate (E1S) is currently used in hormone replacement therapy in post-menopausal women. While isotope studies have demonstrated that E1S is metabolised in a similar way after administration by either the oral or intravenous route, pharmacokinetic studies point to its efficient extraction and metabolism by the liver. E1S was accordingly administered orally and intravenously at pharmacological dosages in a group of post-menopausal women and its conversion to oestrone (E1) and oestradiol (E2) was determined. We were able to demonstrate that E1S may cross the splanchnic area unaltered, since its conversion to E1 and E2 was similar after administration by each of the routes investigated.
Department of Reproductive Medicine, University of Bologna, Italy.
V M
VM
Jasonni
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S
Naldi
P
P
Ciotti
C
C
Bulletti
C
C
Flamigni
D000284:Administration, Oral; D004958:Estradiol / Q000378:metabolism; D004970:Estrone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism; D008593:Menopause / Q000378:metabolism*; D008875:Middle Aged; D013152:Splanchnic Circulation
D004970:Estrone; D004958:Estradiol; C017296:estrone sulfate