[Evaluation of isoenzymes of creatine kinase and lactate dehydrogenase in cases of suspected acute myocardial infarct].
In 176 patients who were hospitalized with a suspected anterior myocardial infarction, the total enzymatic activity of CPK and LDH in addition to the percentage of various isoenzymes have been determined through electrophoretic separation. The blood samples were taken upon the patients admittance to the hospital and repeated every 6 hours until the 24th hour after admittance. We have considered significant an increase of CPK-MB of more than 6% of the total, along with the LDH1/LDH2 ratio greater than 1. We have also taken into consideration the LDH1/LDH-total ratio. The patients were then subdivided into four groups and the results obtained were compared to the electrocardiographic data. Our results confirmed the need to examine both isoenzymatic groups for a correct laboratory diagnosis of anterior myocardial infarction.
Laboratorio di analisi chimico-cliniche e microbiologiche, Presidio Ospedaliero, U.S.L. 9, Prato, Firenze.
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D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D009203:Myocardial Infarction / Q000175:diagnosis / Q000201:enzymology*; D012189:Retrospective Studies; D013997:Time Factors
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase
Valutazione degli isoenzimi della creatina chinasi e della lattato deidrogenasi in casi di sospetto infarto acuto del miocardio.