An acquired Robertsonian translocation dic(14;14)(p11;p11) in a patient with a myelodysplastic syndrome following treatment of multiple myeloma.
Acquired Robertsonian translocations are considered to be very rare chromosome changes in human malignancy, and only three cases have been described. We report a dic(14;14)(p11;p11) in a patient with myelodysplastic syndromes (MDS) following treatment for multiple myeloma. This patient also had other complex chromosomal abnormalities. The pattern of karyotype evolution in this patient was established by a series of cytogenetic studies. The relationship of the complex chromosomal changes to MDS following treatment for multiple myeloma is discussed.
Department of Genetics and Endocrinology, Roswell Park Memorial Institute, Buffalo, NY 14263.
Y S
YS
Fan
M R
MR
Baer
S N
SN
Sait
P
P
Dal Cin
T C
TC
Prentice
H D
HD
Preisler
A A
AA
Sandberg
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002871:Chromosome Banding; D002883:Chromosomes, Human, Pair 14; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000532:radiotherapy; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000235:genetics*; D014178:Translocation, Genetic / Q000187:drug effects
D000970:Antineoplastic Agents; D005819:Genetic Markers