Protective effect of acute ethanol administration on endotoxin-induced liver injury.
The effect of acute administration of ethanol on endotoxin-induced liver injury was studied. Biochemical and histological results indicated that ethanol pretreatment protected endotoxin-induced liver injury through the improvement of hepatic blood circulation, which is probably associated with an inhibitory effect of ethanol on platelet functions and coagulation system.
Arai
M
M
Dept. of Cent. Cli. Lab., School of Med., Univ. of Occupational and Environmental Health, Kita-kyushu City, Japan.
Okuno
F
F
Hirano
Y
Y
Nakano
S
S
Kobayashi
T
T
Ishii
H
H
Tsuchiya
M
M
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004731:Endotoxins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004731:Endotoxins; D000431:Ethanol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase