Lack of effect of opioid compounds on angiotensin II responses of bovine adrenal medullary cells.
Angiotensin II (10 nM) increased basal adrenaline and noradrenaline secretion from cultured bovine adrenal chromaffin cells by 2.5- to 3-fold and 4- to 6-fold, respectively, and stimulated basal accumulation of inositol phosphates more than 2-fold. Etorphine and diprenorphine in the range 10(-9) to 10(-5) M had no effect on the catecholamine secretion induced by angiotensin II, and, at 10(-8) and 10(-5) M, had no effect on angiotensin II-induced inositol phosphate accumulation. The functions of adrenal medullary opioid receptors remain to be determined.
Department of Biochemistry, University of Melbourne, Parkville, Vic., Australia.
P D
PD
Marley
S J
SJ
Bunn
D000313:Adrenal Medulla / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D002417:Cattle; D002478:Cells, Cultured; D004174:Diprenorphine / Q000494:pharmacology*; D005048:Etorphine / Q000494:pharmacology*; D007295:Inositol Phosphates / Q000378:metabolism*; D009019:Morphinans / Q000494:pharmacology*; D013403:Sugar Phosphates / Q000378:metabolism*
D002395:Catecholamines; D007295:Inositol Phosphates; D009019:Morphinans; D013403:Sugar Phosphates; D000804:Angiotensin II; D004174:Diprenorphine; D005048:Etorphine