[Chemical reactions in double-stranded nucleic acids. IV. Cyanogen bromide--a highly effective reagent in the condensation of oligodeoxyribonucleotides].
Cyanogen bromide was found to induce a smooth and highly efficient condensation of oligonucleotide blocks within DNA duplexes. This template-directed reaction proceeds in the aqueous solution at 0 degree C for 1-2 min. Cyanogen bromide catalyzes the formation not only of phosphodiester, but also of unnatural phosphoramide and pyrophosphate interoligomer bonds.
N I
NI
Sokolova
D T
DT
Ashirbekova
N G
NG
Dolinnaia
Z A
ZA
Shabarova
D055598:Chemical Phenomena; D002621:Chemistry; D003488:Cyanogen Bromide; D004247:DNA; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D004247:DNA; D003488:Cyanogen Bromide
Khimicheskie reaktsii v dvuspiral'nykh nukleinovykh kislotakh. IV. Bromtsian--vysokoéffektivnyĭ reagent pri kondensatsii oligodezoksiribonukleotidov.