Flunarizine and migraine in childhood. An evaluation of endocrine function.
Flunarizine was tested for prophylactic efficacy and for side effects in 10- to 13-year-old patients with severe migraine (greater than 2 attacks per month). The 13 preadolescents received a single 5-mg dose at night for 2 months. The attack frequency decreased significantly, and the effect was maintained over time. The endocrine status, investigated before and after treatment, showed no significant interference with pituitary, beta-pancreatic, or gonadal function.
Guidetti
V
V
Istituto di Neuropsichiatria Infantile, Università La Sapienza, Roma, Italy.
Moscato
D
D
Ottaviano
S
S
Fiorentino
D
D
Fornara
R
R
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D005260:Female; D005444:Flunarizine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006442:Glycated Hemoglobin / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood / Q000517:prevention & control*; D010907:Pituitary Hormones / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood
D000305:Adrenal Cortex Hormones; D001786:Blood Glucose; D005444:Flunarizine; D006442:Glycated Hemoglobin; D012739:Gonadal Steroid Hormones; D010907:Pituitary Hormones; D013963:Thyroid Hormones