Plasma esterase activity in patients with aspirin-sensitive asthma or urticaria.
Plasma aspirin esterase activity and cholinesterase activity were reduced in patients with aspirin sensitive asthma and aspirin sensitive urticaria compared to asthmatic and dermatological controls. Phenylacetate (non specific) esterase activities, were however unaltered in these patients. The reason for the lower activity is uncertain but it does not appear to be due to genetically determined lower cholinesterase or due to the avoidance of aspirin by sensitive patients. A low aspirin esterase activity may be a contributory factor in precipitating these aspirin sensitive reactions.
Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne, UK.
F M
FM
Williams
S I
SI
Asad
M H
MH
Lessof
M D
MD
Rawlins
D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced / Q000201:enzymology*; D002091:Butyrylcholinesterase / Q000097:blood; D002802:Cholinesterases / Q000097:blood; D004950:Esterases / Q000097:blood*; D006801:Humans; D014582:Urticaria Pigmentosa / Q000139:chemically induced / Q000201:enzymology*
D004950:Esterases; D002091:Butyrylcholinesterase; D002802:Cholinesterases; D001241:Aspirin