[Study of the deglycosylation of various antibiotics of the vancomycin group].
Conditions for deglycosylation of a number of antibiotics belonging to the vancomycin group were studied. A two-stage process including methanolysis followed by acidolysis in a mixture of trifluoracetic acid and HC1 in the presence of nucleophile was shown optimal for formation of a biologically active aglycone of ristomycin A while for formation of the vancomycin aglycone a one-stage process (trifluoracetic acid/HC1--acidolysis) was optimal. A scheme for isolation and purification of the aglycones of ristomycin A and vancomycin is presented.
Kobrin
M B
MB
Fedorova
G B
GB
Katrukha
G S
GS
D055598:Chemical Phenomena; D002621:Chemistry; D006031:Glycosylation; D006851:Hydrochloric Acid / Q000494:pharmacology; D012310:Ristocetin / Q000032:analysis*; D014269:Trifluoroacetic Acid / Q000494:pharmacology; D014640:Vancomycin / Q000032:analysis*
D012310:Ristocetin; C016719:ristocetin A; D014640:Vancomycin; D014269:Trifluoroacetic Acid; D006851:Hydrochloric Acid
Issledovanie protsessa deglikozilirovaniia nekotorykh antibiotikov vankomitsinovoĭ gruppy.