'Pulsed' immunosuppressive therapy in the treatment of immunologically induced corneal and scleral disease.
'Pulsed' immunosuppressive therapy, using methylprednisolone with or without cyclophosphamide, has effectively controlled severe destructive corneal and scleral disease that had been unresponsive to oral steroids. Thirty-seven patients have been treated in this manner and the results, complications and possible mechanism of action are discussed.
Moorfields Eye Hospital, London.
P A
PA
Meyer
P G
PG
Watson
W
W
Franks
P
P
Dubord
D000368:Aged; D003316:Corneal Diseases / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy; D007262:Infusions, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D012590:Sclera
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D008775:Methylprednisolone