Hidradenitis suppurativa of the anogenital region: response to isotretinoin.
Hidradenitis suppurativa, a chronic relapsing disease of apocrine gland-bearing areas, most frequently occurs in the axillae, groin, perineal, and perianal regions. Hidradenitis of vulva is frequently misdiagnosed and inadequately treated. The case of a 15-year-old nulliparous black female adolescent referred for evaluation of multiple draining fistulas of the anogenital region is presented. Diagnostic studies for granulomatous disease were negative. Results of a barium enema were normal and biopsies were compatible with the diagnosis of hidradenitis suppurativa. She was treated for 22 weeks with isotretinoin, 1 mg/kg daily, with an excellent response. Side effects were minor and included cheilitis, mild xerosis, and a transient elevation of serum alkaline phosphatase levels. Few patients with severe hidradenitis have been responsive to this synthetic vitamin A derivative. A review of the literature indicates that the results of treatment with isotretinoin for hidradenitis have been at best equivocal. Isotretinoin should never be used during pregnancy because of known teratogenic effects. Women of childbearing age must use effective contraception during treatment.
Department of Obstetrics and Gynecology, Medical College of Georgia, Augusta 30912.
C F
CF
Brown
D G
DG
Gallup
V M
VM
Brown
D000293:Adolescent; D001004:Anus Diseases / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D015474:Isotretinoin; D010502:Perineum; D013492:Suppuration; D013543:Sweat Gland Diseases / Q000188:drug therapy* / Q000473:pathology; D014212:Tretinoin / Q000627:therapeutic use*; D014845:Vulvar Diseases / Q000188:drug therapy* / Q000473:pathology
D014212:Tretinoin; D015474:Isotretinoin