[Stability test of trituratio paraoxoni AB-DDR 78].
Trituratio Paraoxoni was stored at various high temperatures and the content of the intact active ingredient was determined in suitable duration periods. The degradation of paraoxon follows up to 25% first order reaction. The reaction equilibrium constant calculated produces an Arrhenius-plot. The extrapolation of the reaction equilibrium constant to 20 degrees C was done under consideration of weighting factors and included a different number of loading temperatures and measurements of the concentration per time period. The shelf use calculated corresponds to the results of long-range storage. The necessity of an assaying as prescribed by AB-DDR 78 is confirmed.
Wollmann
H
H
Sektion Pharmazie der Ernst-Moritz-Arndt-Universität Greifswald.
Müller
C
C
D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D010261:Paraoxon / Q000032:analysis*; D013696:Temperature; D013997:Time Factors
D010261:Paraoxon
Stabilitätsprüfung von Trituratio Paraoxoni AB-DDR 78.