CGP 11.952: an experimental benzodiazepine derivative. Effects on cognitive functioning in patients with epilepsy.
1. In two open studies using patients with intractable epilepsy, the effects of CGP 11.952, a triazolyl benzophenone, on cognitive functioning were assessed by means of a computerized neuropsychological battery. 2. In the first study CGP 11.952 turned out to have a positive effect on information processing speed, perceptual sensitivity and preciseness of responses. 3. Negative effects were found on reaction time. 4. In the second study this latter effect was less clear. 5. A striking result was the less negative effect on memory consolidation under influence of CGP 11.952 in comparison with other benzodiazepines.
Alpherts
W C
WC
Instituut voor Epilepsiebestrijding, Meer en Bosch/De Cruquiushoeve, Heemstede, The Netherlands.
Aldenkamp
B P
BP
Moerland
R C
RC
D000293:Adolescent; D000328:Adult; D001288:Attention / Q000187:drug effects; D001577:Benzophenones / Q000009:adverse effects*; D003071:Cognition / Q000187:drug effects*; D004827:Epilepsy / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects
D001577:Benzophenones; C044664:CGP 11952