Effects of all-trans retinoic acid on the morphology of human epidermal cells in vitro.
The effects of all-trans retinoic acid on human epidermal cell cultures were studied using ultrastructural techniques. Differentiation and stratification were reduced in retinoic acid treated epidermal cells. Treated cells developed a rounded appearance and seemed to contain more granules and vacuoles than usual. Desmosomes were not found in treated cells.
Department of Medicine (Dermatology), University of Wales College of Medicine, Health Park, Cardiff, UK.
I
I
Konohana
T
T
Hashimoto
P J
PJ
Dykes
R
R
Marks
D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D004817:Epidermis / Q000187:drug effects* / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D014212:Tretinoin / Q000494:pharmacology*
D014212:Tretinoin