[Effect of ischemic state on myocardial utilization of nonesterified fatty acids].
In patients with ischemic heart disease (IHD), neurocirculatory dystonia (NCD) and acute myocardial infarction (AMI), we observed significant, positive, linear correlations between total concentration of non-etherified fatty acids (NEFA) as well as between the percentage of individual fatty acids in arterial and coronary sinus blood. Correlation analysis of the results demonstrated that in patients with IHD and NCD there is significant myocardial NEFA extraction which is highly reduced by electrically induced myocardial ischemia in patients with IHD and by increased myocardial load in patients with NCD. These changes are more evident in patients with IHD. Patients with AMI exhibited minor myocardial NEFA extraction, similar to that in patients with IHD after stimulation, but much higher NEFA concentration in arterial and coronary sinus blood. Determination of NEFA levels in arterial and coronary sinus blood in patients with AMI and their temporal dynamics may be helpful for evaluation of the degree of the disease severity and can also be of prognostic value.
A I
AI
Kuz'min
V D
VD
Vakhliaev
D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D009449:Neurocirculatory Asthenia / Q000097:blood / Q000378:metabolism
D005230:Fatty Acids, Nonesterified
Vliianie ishemicheskogo sostoianiia na utilizatsiiu miokardom neésterifitsirovannykh zhirnykh kislot.