Modulation of the transferrin receptor during DMSO-induced differentiation in HL-60 cells.
When HL-60 cells are induced to differentiate by dimethyl sulfoxide along a granulocytic pathway there is a fivefold decrease in the total number of transferrin receptors within 3 days, as compared to untreated cells. This decrease is due primarily to a rapid decline in the synthesis of the receptor rather than an increase in the degradation of the receptor. The decrease in transferrin receptor synthesis is a specific and early event that precedes the cessation of cell proliferation, differentiation, and the decrease in total protein synthesis.
Department of Biology, Syracuse University, New York 13244.
C A
CA
Enns
M A
MA
Mulkins
H
H
Sussman
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Root
D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D003513:Cycloheximide / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D015470:Leukemia, Myeloid, Acute; D011990:Receptors, Transferrin / Q000096:biosynthesis / Q000187:drug effects / Q000378:metabolism*
D011990:Receptors, Transferrin; D003513:Cycloheximide; D004121:Dimethyl Sulfoxide