[Effects of normobaric oxygen on rat hepatocytes].
Exposure of adult rats to oxygen (100%) during 55 hrs decreases their sleeping time induced by pentobarbital and doesn't modify their paralysis time provoked by zoxazolamine. At 48 and 55 hrs, the hepatic cytochrome P-450 decreases significantly. Morphological study showed tissular changes suggestive of hepatic hemodynamic perturbations, which are probably responsible for the functional modifications.
Unité N. 13 INSERM Hôpital Claude Bernard, Paris, France.
A
A
Nasraoui
G
G
Feldman
J J
JJ
Pocidalo
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D008862:Microsomes, Liver / Q000201:enzymology*; D010100:Oxygen / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D003577:Cytochrome P-450 Enzyme System; D010100:Oxygen
Effets de l'oxygène normobare sur l'hépatocyte du rat.