[Structural and physico-chemical properties of amino acids of functionally important regions of proteins].
A correlation of the localization of functionally important regions with places having low and high values on twelve profiles built on a basis of amino acid sequences was analysed using a broad set of proteins. The profiles of hydrophilicity, resemblance to the sequences of human proteins, flexibility, mutability and others were considered. The resemblance profile was plotted by the program fixing short similar fragments in the testing protein and 92 human ones. The active centres were shown to be located in the primary structure regions having relatively low values on the resemblance profiles. Similar effect was observed in the mutability and alpha-helicity profiles. The potential functionally important sites of the human leukocyte interferon and interleukin-2 isolated on the basis of the analysis of this profiles were in accord with the available literary data.
Eroshkin
A M
AM
Zhilkin
P A
PA
Popkov
I K
IK
Kulichkov
V A
VA
D000596:Amino Acids; D001665:Binding Sites; D005075:Biological Evolution; D006801:Humans; D009154:Mutation; D011487:Protein Conformation; D011506:Proteins
D000596:Amino Acids; D011506:Proteins
Strukturnye i fiziko-khimicheskie svoĭstva aminokislot funktional'no vazhnykh uchastkov belkov.