Phenytoin binding in healthy volunteers.
The pharmacologic effect of phenytoin is directly related to the unbound concentration in the serum, which previously has been reported in the literature to be approximately 10%. The results of 13 out of 14 20-35 year-old healthy male volunteers studied indicate that less than 10% unbound phenytoin is present in the majority of subjects taking two different doses of phenytoin.
Berg
M J
MJ
College of Pharmacy, University of Iowa, Iowa City 52242.
Ebert
B E
BE
Fincham
R W
RW
Schottelius
D D
DD
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D010672:Phenytoin / Q000378:metabolism*; D011485:Protein Binding
D001798:Blood Proteins; D010672:Phenytoin