Serum CPK-BB isoenzyme in the assessment of brain damage in asphyctic term infants.
Serum creatine phosphokinase-BB activities were measured at 4 and at 10 hours of life in 33 asphyctic full-term infants. The infants were followed for a mean period of 16 months. Enzyme activities at 4 hours of life were significantly higher in those neonates who died of severe hypoxic-ischemic encephalopathy or developed neurological sequelae than in those who did not present neurological abnormalities during the follow-up time. The specificity of the enzyme assay in order to predict the neurological outcome was inferior to that of cranial computed tomography or a combined clinical-electroencephalographic evaluation. It appears that the presence of elevated serum creatine phosphokinase-BB activity can be a sensitive indicator of conspicuous brain damage, but it is of limited value to predict the neurological outcome after neonatal asphyxia.
Service of Neonatology, Clínica Infantil, Ciudad Sanitaria La Paz, Madrid, Spain.
F
F
Fernández
A
A
Verdú
J
J
Quero
A
A
Pérez-Higueras
D001238:Asphyxia Neonatorum / Q000097:blood* / Q000150:complications; D003402:Creatine Kinase / Q000097:blood*; D004569:Electroencephalography; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D002534:Hypoxia, Brain / Q000175:diagnosis / Q000201:enzymology*; D007231:Infant, Newborn; D007527:Isoenzymes; D014057:Tomography, X-Ray Computed
D007527:Isoenzymes; D003402:Creatine Kinase