Prenatal and neonatal irradiation in dogs: hematologic and hematopoietic responses.
Hematologic and hematopoietic responses were evaluated in beagle dogs following a single prenatal (35 days gestation) or neonatal (10 days postpartum) exposure to 1.5 Gy 60Co gamma radiation. Hematopoiesis was studied by the in vitro culture of bone marrow granulocyte-macrophage progenitors (CFU-GM). Prenatally irradiated dogs exhibited a progressive, significant reduction in CFU-GM which was accompanied by decreases in peripheral blood leukocytes up to 24 weeks of age. Dogs which were neonatally irradiated also demonstrated a significant reduction in CFU-GM which was accompanied by significant alterations in peripheral white and red blood cell parameters. This was transient, however, and these dogs showed partial recovery of CFU-GM and hematologic parameter by 24 weeks of age. The persistent CFU-GM deficit in prenatally irradiated dogs suggests a relatively greater sensitivity of fetal marrow as compared to neonatal bone marrow for long-term damage by ionizing radiation.
Nold
J B
JB
Collaborative Radiological Health Laboratory, Colorado State University, Fort Collins 80523.
Miller
G K
GK
Benjamin
S A
SA
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001772:Blood Cell Count; D004285:Dogs; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D006410:Hematopoiesis / Q000528:radiation effects*; D011247:Pregnancy; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000503:physiopathology*