Co-operativity in sodium-independent taurine binding to brain membranes in the mouse.
Sodium-independent taurine binding to mouse brain membranes treated twice with Triton X-100 exhibited properties of positive co-operativity, suggesting that two or more taurine molecules interact at the binding site. The proposed taurine antagonist 6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine-1,1-dioxide and the new anticonvulsant taurine derivative taltrimide as well as glycine and GABA with their antagonists displaced taurine binding, strychnine being the most effective.
Department of Biomedical Sciences, University of Tampere, Finland.
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D000818:Animals; D001581:Benzothiadiazines / Q000378:metabolism; D001667:Binding, Competitive; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D007700:Kinetics; D051379:Mice; D012964:Sodium / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism*; D013654:Taurine / Q000378:metabolism*
D001581:Benzothiadiazines; D013654:Taurine; C032946:6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide; D012964:Sodium