2,6-Dimethylphenol: a new metabolite of mexiletine.
A new metabolite, 2,6-dimethylphenol obtained by O-dealkylation of mexiletine by rabbit liver was identified. A g.c.-f.i.d. method was developed for its analysis in hepatic homogenates and some of the characteristics of the metabolic reaction were studied. Formation of 2,6-dimethylphenol is microsomal and is optimal under aerobic conditions. Both carbon monoxide and n-octylamine significantly depress this O-dealkylation reaction.
Ecole de Pharmacie, Université Laval, Ste-Foy, Québec, Canada.
O
O
Grech-Bélanger
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Turgeon
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M
Lalande
D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008801:Mexiletine / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D011817:Rabbits; D013347:Subcellular Fractions / Q000378:metabolism; D014992:Xylenes / Q000302:isolation & purification / Q000378:metabolism*
D014992:Xylenes; D008801:Mexiletine; C036531:2,6-xylenol