[Therapeutic and preventive effectiveness of zyxorin during poisoning with anticholineesterase pesticides].
Zyxorin (50-100 mg/kg) was found to produce a significant increase of the content (activity) of components of electron transport microsomal circuit and is similar to phenobarbital by its inducing effect. At preventive and therapeutic-preventive administration it enhances resistance of albino rats to anticholinesterase pesticides (actellis, valexon, 0,0-dimethyl-0-2,2-dichlorvinylphosphate, clorofos, hostaquick, dioxycarb, primor, sevine, furadan), prevents the development of neuromuscular blockade. The introduction of zyxorin into a complex therapy with specific agents (atropine, reactivators of cholinesterase) potentiates their antidotic effect at poisoning with DDVP.
Kokshareva
N V
NV
Kagan
Iu S
IuS
Ovsiannikova
L M
LM
Seberini
S
S
Ungvari
D
D
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use; D001285:Atropine / Q000627:therapeutic use; D002219:Carbamates; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D002801:Cholinesterase Reactivators / Q000627:therapeutic use; D004357:Drug Synergism; D007306:Insecticides / Q000506:poisoning*; D008099:Liver / Q000201:enzymology; D008862:Microsomes, Liver / Q000201:enzymology; D009943:Organophosphorus Compounds; D051381:Rats
D000931:Antidotes; D002219:Carbamates; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D007306:Insecticides; D009943:Organophosphorus Compounds; D001285:Atropine
Lechebno-profilakticheskaia éffektivnost' ziksorina pri intoksikatsii antikholinésteraznymi pestitsidami.