[Initial experience with using phosphocreatine in patients in the early (up to 6 hours) period of myocardial infarction].
A randomized study of 60 patients with myocardial infarction (MI) admitted to hospital in the first 6 hours of the disease was performed in order to study the effect of phosphocreatine (PC) on the course of MI. 30 patients were treated with PC; control group consisted also of 30 patients. PC infusion in the early period of MI resulted in the decreased frequency of ventricular arrhythmias (including paroxysms of ventricular tachycardia) and lowered likelihood of cardiac failure development. No reliable influence of PC on the central hemodynamics, heart rate, heart conduction and myocardial necrosis size was determined.
Samarenko
M B
MB
Afonskaia
N I
NI
Dvoskina
I S
IS
Ruda
M Ia
MIa
D000328:Adult; D000368:Aged; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D010725:Phosphocreatine / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
D010725:Phosphocreatine
Pervyĭ opyt primeneniia fosfokreatina u bol'nykh v rannie (do 6 ch) sroki razvitiia infarkta miokarda.