Effect of nicergoline on learning and memory.
The anti-amnestic action of nicergoline was studied using the following experimental methods for learning and memory impairment, based on passive avoidance response: amnesia induced by maximal electroshock in mice, scopolamine-induced amnesia in mice and amnesia by paradoxical sleep deprivation in rats. Piracetam, meclofenoxate, pyritinol, deanol and phenazepam were used as reference drugs. The results show that nicergoline demonstrates well-expressed anti-amnestic effect manifested by reducing the amnestic effect of maximal electroshock, scopolamine or paradoxical sleep deprivation, its effect being equal to or more pronounced than piracetam, meclofenoxate, pyritinol, deanol and phenazepam.
Pharmacological Research Institute, USSR Academy of Medical Sciences, Moscow.
T A
TA
Voronina
L N
LN
Nerobkova
T L
TL
Garibova
M
M
Dikova
R
R
Nikolov
M
M
Nikolova
N V
NV
Markina
D000647:Amnesia / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004597:Electroshock; D004873:Ergolines / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D009530:Nicergoline / Q000494:pharmacology*; D051381:Rats; D012601:Scopolamine / Q000037:antagonists & inhibitors; D012892:Sleep Deprivation
D004873:Ergolines; D012601:Scopolamine; D009530:Nicergoline