A novel device for the automated administration of test compounds to laboratory animals.
A prototype instrument is described that permits efficient administration of test compounds to laboratory animals by intubation. The system integrates a balance, a computer and a volumetric dispenser. Complete animal identification, weight and dose records are kept and may be interfaced with mainframe computers. A range of doses may be delivered from a single stock solution. No carryover is evident between doses. The system is accurate, precise and rugged. The system is cost effective relative to current manual gavage techniques and offers added safety for investigators handling toxic materials.
Crowell
J A
JA
Pathology Associates, Inc., National Center for Toxicological Research, Jefferson, AR 72079.
Parker
R M
RM
Bucci
T J
TJ
Dacre
J C
JC
D000284:Administration, Oral; D000818:Animals; D000830:Animals, Laboratory; D001835:Body Weight; D004334:Drug Administration Schedule; D008838:Microcomputers; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D014116:Toxicology / Q000295:instrumentation*
D004364:Pharmaceutical Preparations