Simplifying infusion chemotherapy: preliminary communication.
A low-intervention policy for Hickman catheter maintenance has been evaluated and found to be safe and cost effective. A simple, lightweight, disposable device has been used for 24-hour ambulatory home infusion. Implementation of this policy as part of a prospective randomized trial of single-agent chemotherapy in advanced breast cancer has demonstrated that slow intravenous infusion reduces the acute toxicity of epirubicin when compared with bolus injection.
Ebbs
S R
SR
Department of Surgery, King's College Hospital, Rayne Institute, London.
Saunders
J A
JA
Roberts
J V
JV
Baum
M
M
Bates
T
T
Morris
J E
JE
D001943:Breast Neoplasms / Q000188:drug therapy*; D002406:Catheterization, Peripheral; D004317:Doxorubicin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D015251:Epirubicin; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D013237:Stereoisomerism
D015251:Epirubicin; D004317:Doxorubicin