[Morphofunctional state of the hypothalamic-pituitary neurosecretory system of rats flown on Cosmos-1667].
Morphological and morphometric data were used for comparative analysis of changes in the major compartments of the hypothalamic-pituitary neurosecretory system of Cosmos-1667 experimental and control rats. The flown rats showed morphological signs of inhibited ADH production. This inhibition may facilitate fluid excretion and development of a new hydration level at an early stage of adaptation to microgravity. The enhanced ADH secretion from neurons of supraoptic nuclei of the hypothalamus and axons of the posterior pituitary may lead to water retention and compensation of water loss after return to Earth's gravity.
Alekseev
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EI
D000818:Animals; D007030:Hypothalamo-Hypophyseal System / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009490:Neurosecretory Systems / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013026:Space Flight; D014667:Vasopressins / Q000378:metabolism; D014882:Water-Electrolyte Balance; D014893:Weightlessness / Q000009:adverse effects
D014667:Vasopressins
Morfofunktsional'noe sostoianie gipotalamo-gipofizarnoĭ neĭrosekretornoĭ sistemy krys, éksponirovannykh na biosputnike "Kosmos-1667".