Plasma secretin, plasma cholecystokinin, pancreaticobiliary secretion, and fat absorption: effect of duodenal osmolality and polysorbate 80.
In 20 normal persons we investigated the effects of duodenal osmolality on the release of secretin and cholecystokinin (CCK), pancreaticobiliary secretion, and fat absorption after intestinal infusion of emulsified oleic acid (pH 6.0). The release of CCK was found to be unaffected by the changes in osmolality, whereas the plasma levels of secretin were affected in parallel with volume and bicarbonate secretion. An inverse relation was found between fatty acid absorption and release of secretin and bicarbonate secretion but not between fatty acid absorption and release of CCK. It is suggested that the secretin and CCK cells respond differently to emulsified oleic acid.
Surgical Dept. C, Rigshospitalet, Copenhagen, Denmark.
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Olsen
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Schaffalitzky de Muckadell
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Cantor
D000042:Absorption; D000328:Adult; D001659:Biliary Tract / Q000378:metabolism*; D002766:Cholecystokinin / Q000097:blood*; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D009829:Oleic Acids / Q000494:pharmacology; D009994:Osmolar Concentration; D010179:Pancreas / Q000378:metabolism*; D010461:Peptones / Q000494:pharmacology; D010477:Perfusion; D011136:Polysorbates / Q000494:pharmacology*; D012633:Secretin / Q000097:blood*
D005227:Fatty Acids; D009829:Oleic Acids; D010461:Peptones; D011136:Polysorbates; D012633:Secretin; D002766:Cholecystokinin