Antibiotic as ligand. Coordinating behavior of the cephalexin towards Zn(II) and Cd(II) ions.
The complex formation equilibria of Zn(II) and Cd(II) with cephalexin have been studied through potentiometric titrations. Experimental data were analyzed using the least squares computer program SUPERQUAD. The stability constants were 1g beta ZnCEX+ = 2.40, 1g beta Zn(CEX)(OH) = -4.54, 1g beta CdCEX+ = 2.18, and 1g beta Cd(CEX)(OH) = -5.18 (I = 0.1 M NaNO3), CEX complexes of formulae Zn(CEX)2(3)H2O and Cd(CEX)(OH)H2O have been synthesized and characterized by elemental analysis, IR spectra, conductivity measurements, and electronic and NMR spectra. The thermal behavior of the synthesized compounds were studied by TGA and DTA. We conclude that the metal ion interacts with the amido group of CEX.
Lozano
M J
MJ
Departamento de Química Inorgánica, Facultad de Farmacia, E. García-España, Universidad de Valencia, Spain.
Borrás
J
J
D002506:Cephalexin; D003300:Copper; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D012984:Software; D015032:Zinc
D008024:Ligands; D003300:Copper; D015032:Zinc; D002506:Cephalexin