Tumor imaging with anti-CEA antibody labeled 19F emulsion.
The possibility of using 19F MRI for detection of tumors using a 2-T NMR system was examined in animals. Anticarcino-embryonic antigen (CEA) antibody conjugated with perfluorochemical (perfluorotributylamine, FTBA) was administered to nude mouse inoculated with LOVO, a CEA-producing human cancer cell line. Tumor imaging based on the 19F NMR was examined after excision of the tumors from nude mice (ex vivo). The imaging pattern of the tumor coincided with the antibody distribution determined immunohistologically.
Second Department of Surgery, Osaka University School of Medicine, Japan.
M
M
Shimizu
T
T
Kobayashi
H
H
Morimoto
N
N
Matsuura
T
T
Shimano
N
N
Nomura
S
S
Itoh
M
M
Yamazaki
N
N
Iriguchi
T
T
Yamamoto
D000818:Animals; D000912:Antibodies, Neoplasm; D002272:Carcinoembryonic Antigen / Q000276:immunology*; D005461:Fluorine; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000175:diagnosis*; D014183:Transplantation, Heterologous
D000912:Antibodies, Neoplasm; D002272:Carcinoembryonic Antigen; D005461:Fluorine