Inflammatory fibroid polyp of the gastrointestinal tract: possible origin in myofibroblasts? A study of twelve cases.
Inflammatory fibroid polyp (eosinophilic granuloma) is a rare benign condition found in the gastro-intestinal tract. Approximately 200 cases have been described in the literature. It is generally considered as a granulation tissue of a peculiar type; however its cellular composition remains controversial. Either macrophages, fibroblasts or myofibroblasts have been proposed as its main cellular constituents. A retrospective study of 12 cases (8 gastric and 4 intestinal locations) based on histology, immuno-histochemistry and electron microscopy, would suggest that this condition is truly a peculiar type of granulation tissue made up primarily of myofibroblasts.
Widgren
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Département de Pathologie, Centre Médical Universitaire, CH-1211 Genève, Switzerland.
Pizzolato
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GP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004803:Eosinophilic Granuloma / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005350:Fibroma / Q000209:etiology / Q000473:pathology*; D005767:Gastrointestinal Diseases / Q000473:pathology; D006801:Humans; D007078:Ileal Neoplasms / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000209:etiology / Q000473:pathology*