The respiratory responses of subjects with allergic rhinitis to ozone exposure and their relationship to nonspecific airway reactivity.
Ozone exposure in man produces changes in respiratory function and symptoms. There is a large degree of unexplained intersubject variability in the magnitude of these responses. There is concern that individuals with chronic respiratory diseases may also be more responsive to ozone than normal individuals. The purpose of this study was to describe the responses of subjects with allergic rhinitis to ozone exposure and to compare these responses to those previously observed in normal individuals. A further purpose was to measure the association of baseline nonspecific airway reactivity with changes in lung function and respiratory symptoms following ozone exposure. A group of 26 nonasthmatic subjects with allergic rhinitis performed a bronchial inhalation challenge with histamine and subsequently underwent two hour exposures to both clean air and to 0.18 part per million ozone with alternating periods of rest and heavy exercise. The airway reactivity of this group of subjects was no greater than that of a comparable group of subjects without allergic rhinitis. The respiratory responses of these subjects to ozone exposure were similar to those previously reported for subjects without allergic rhinitis with the exception that the allergic rhinitis subjects appeared to have a modestly increased bronchoconstrictor response compared to normals. Furthermore, we observed no significant relationships between nonspecific airway reactivity and response to ozone as measured by changes in lung function or the induction of symptoms.
McDonnell
W F
WF
Clinical Research Branch, United States Environmental Protection Agency, Research Triangle Park, North Carolina.
Horstman
D H
DH
Abdul-Salaam
S
S
Raggio
L J
LJ
Green
J A
JA
D000293:Adolescent; D000328:Adult; D006801:Humans; D008297:Male; D010126:Ozone / Q000494:pharmacology*; D005082:Physical Exertion; D012119:Respiration / Q000187:drug effects*; D012129:Respiratory Function Tests; D012137:Respiratory System / Q000187:drug effects* / Q000503:physiopathology; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology*; D012882:Skin Tests; D013147:Spirometry
D010126:Ozone