Screening of the Philadelphia variant of galactokinase in racially unmixed black Africans: first results.
In previous reports, it was emphasized that the gene GALKA of galactokinase was the predominant allele in white populations and that another allele, GALKP, which reduces red blood cell activity (RBC GALK), was common in black people. In a group of black Americans living in Philadelphia, the frequency of GALKA was found to be very close to values expected from independent estimation of white admixture. The authors have suggested that the ancestors of these blacks might have been virtually all GALKP homozygous. We have looked for carriers of GALKP genotypes among 73 black Africans; only 33 probands were shown to have a low RBC GALK. To detect white admixture, immunoglobulin allotypes Km and Gm were investigated in 50 individuals of the sample; 15 GALKP carriers with low RBC GALK and 30 of 35 individuals with normal RBC GALK shared Gm phenotypes exclusive to blacks. Our work demonstrates for the first time the polymorphism of GALK in black Africans in the absence of white admixture.
Soni
T
T
Laboratoire Central de Biochimie, C.H.U. de Bicêtre, Le Kremlin-Bicêtre, France.
Brivet
M
M
Blanc
M
M
Jaeger
G
G
Lemonnier
A
A
D000349:Africa; D000483:Alleles; D044383:Black People; D005260:Female; D005686:Galactokinase / Q000235:genetics*; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics; D007131:Immunoglobulin Km Allotypes / Q000235:genetics; D008297:Male; D011110:Polymorphism, Genetic; D044465:White People; D001741:Black or African American
D005819:Genetic Markers; D007129:Immunoglobulin Gm Allotypes; D007131:Immunoglobulin Km Allotypes; D005686:Galactokinase