[Effect of vagotomy on the duodenal mechanisms regulating gastric secretion].
Gastric acid secretion, gastrin and secretin serum levels after duodenal acidification were studied in 6 dogs, before and after a troncular vagotomy was performed in each one. After duodenal acidification in normal dogs, a 45.2% inhibition of gastric acid secretion with parallel 55-84% increases in the serum secretin levels, without changes in the serum gastrin levels, was noted. When a troncular vagotomy was performed in the same dogs, duodenal acidification produced a 20% (non significant) inhibition of gastric acid secretion with parallel 34-72% increases in the serum secretin levels and without changes in the serum gastrin levels. It is concluded that vagus nerve is necessary to assess a physiological inhibition of gastric secretion after duodenal acidification and it is suggested that humoral and nervous factors are implicated and coexist in these mechanisms.
Lanas
A
A
Servicio de Aparato Digestivo, Hospital Clínico Universtario, Zaragoza, España.
Alcalde
J
J
García-Cabo
R
R
Morandeira
J R
JR
Sainz
R
R
D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000502:physiology*; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D005768:Gastrointestinal Hormones / Q000097:blood*; D010418:Pentagastrin / Q000494:pharmacology; D012633:Secretin / Q000097:blood; D014630:Vagus Nerve / Q000502:physiology*
D005755:Gastrins; D005768:Gastrointestinal Hormones; D012633:Secretin; D010418:Pentagastrin
Efecto de la vagotomía en los mecanismos duodenales que regulan la secreción gástrica.