Merocyanines: potential new anticancer agents.
We report the synthesis of a series of merocyanines and the structure-effect relationship as cytotoxic agents for human adenocarcinoma cells in vitro. The cytotoxicity of these compounds in vitro makes them potential anticancer agents. One of these compounds was found active on human and mouse tumor models.
Gruda
I
I
Department of Chemistry-Biology, UQTR, Trois-Rivières, Québec, Canada.
Pagé
M
M
Bolduc
F
F
Laliberté
S
S
Noel
C
C
D000230:Adenocarcinoma / Q000188:drug therapy; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D006801:Humans; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011725:Pyridines