Feasibility study for transdermal delivery of meperidine.
The present study examines the feasibility of meperidine for transdermal delivery. Meperidine possesses characteristics favorable for percutaneous absorption, i.e., a high lipid/water partition coefficient of 25 at pH 7.4, a low molecular weight of 247, and water solubility. Following solubility and apparent partition coefficient experiments, meperidine base rather than salt, was chosen for permeation experiments. The release of meperidine from a drug delivery device (disc) was studied in vitro. Ex vivo permeation of meperidine through excised rat skin was studied using the Thomas diffusion cell, and the fluxes from different solvents were compared. From the in vitro and ex vivo studies, a disc was chosen for final in vivo evaluation in rats, and compared to I.V. and P.O. administration of meperidine.
Ritschel
W A
WA
Division of Pharmaceutics and Drug Delivery Systems, University of Cincinnati Medical Center, OH.
Barkhaus
J K
JK
D000279:Administration, Cutaneous; D000818:Animals; D005260:Female; D008614:Meperidine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D012869:Skin Absorption; D012995:Solubility; D012997:Solvents
D012997:Solvents; D008614:Meperidine