Ibotenic acid lesions of the thalamic medialis dorsalis nucleus in the cat: effects on the sleep-waking cycle.
Bilateral ibotenic acid lesions of the thalamic medialis dorsalis nucleus in chronically implanted cats produced a significant reduction of slow wave sleep. Rapid eye movement sleep was also affected but in a less significant manner. The lesions were limited to the intermediate portion of the nucleus, which receives projections from the brainstem and prosencephalic structures implicated in sleep mechanisms. These results are consistent with the hypothesis that the medialis dorsalis nucleus plays an important role in the induction and maintenance of sleep.
Istituto di Fisiologia Umana II, Milan, Italy.
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D000818:Animals; D002415:Cats; D007051:Ibotenic Acid; D010080:Oxazoles; D012894:Sleep Stages / Q000502:physiology*; D013787:Thalamic Nuclei / Q000473:pathology / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
D010080:Oxazoles; D007051:Ibotenic Acid