A stabilized moment estimator for the beta-binomial distribution.
The beta-binomial distribution has been proposed as a model for the incorporation of historical control data in the analysis of rodent carcinogenesis bioassays. Low spontaneous tumor incidences along with the small number and sizes of historical control groups combine to make the moment and maximum likelihood estimates of the beta-binomial parameters deficient. We therefore propose a stabilized moment estimator for one of the parameters. The stabilized moment estimator is similar to the ridge regression estimator and introduces a shrinkage parameter. Computer simulations were run to examine the behavior of the stabilized moment estimator. The effect of the stabilized moment estimator on the score test for dose-related trend is considered both on simulated data and on an example from the literature.
Eli Lilly and Company, Greenfield, Indiana 46140.
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Tamura
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SS
Young
D000818:Animals; D001699:Biometry; D002273:Carcinogens / Q000633:toxicity*; D003198:Computer Simulation; D008962:Models, Theoretical; D009374:Neoplasms, Experimental / Q000473:pathology; D011336:Probability
D002273:Carcinogens