Pharmacokinetics of phenylethylmalonamide (PEMA) in elderly men.
The pharmacokinetics of phenylethylmalonamide (PEMA) were studied in 6 elderly men after oral administration of a single 400 mg dose. Peak PEMA serum levels were obtained within 4 h of intake, half-life values ranged from 30.7-57.9 h in these elderly men. The elimination half-life was twice as long when compared to a study previously performed in young volunteers.
Streete
J M
JM
Poisons Unit, New Cross Hospital, London, UK.
Berry
D J
DJ
Newberry
J E
JE
Crome
P
P
D000368:Aged; D000369:Aged, 80 and over; D002849:Chromatography, Gas; D006801:Humans; D008297:Male; D008314:Malonates / Q000493:pharmacokinetics*; D010657:Phenylethylmalonamide / Q000493:pharmacokinetics*
D008314:Malonates; D010657:Phenylethylmalonamide