Hyperprolactinaemia increases intraocular pressure in humans.
Nine female and 2 male hyperprolactinaemic patients (plasma prolactin levels averaging 180-420 ng/ml) were subjected to measurements of intraocular pressure (IOP) either under basal conditions or after water load in comparison with 5 healthy volunteers. Basal values of IOP in hyperprolactinaemic patients were 37.8% higher than those of controls. Moreover, after water load hyperprolactinaemic patients showed a sustained increase in IOP that reached values of pathological significance. These results suggest that prolactin may contribute to the hormonal regulation of IOP in humans.
Drago
F
F
Institute of Pharmacology, Faculty of Medicine, Catania, Italy.
Cavallaro
N
N
Dal Bello
A
A
Cavaliere
S
S
Spampinato
D
D
Gorgone
G
G
D000236:Adenoma / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D002924:Ciliary Body / Q000503:physiopathology; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000503:physiopathology*; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000503:physiopathology; D011388:Prolactin / Q000502:physiology; D011981:Receptors, Prolactin / Q000502:physiology
D011981:Receptors, Prolactin; D011388:Prolactin