Ontogenic variation in acute lethality of cadmium in C57BL/6J mice.
Susceptibility of C57BL/6J mice to the lethal effects of parenterally administered Cd declined as a function of age at exposure. The 7-day LD50 increased from 1.65 mg Cd/kg body wt in 7-day-old mice to 4.08 mg/kg in adult mice. Survival time following treatment with Cd also increased as a function of age. High constitutive concentrations of metallothionein, a transition metal-binding protein, in livers of young mice did not protect against the lethality of Cd. These results suggest that, in the mouse, the interaction between Cd and this metal-binding protein may be affected by age at exposure to this toxic metal.
Thomas
D J
DJ
Department of Pediatrics, College of Medicine, University of Nebraska Medical Center, Omaha 68105.
Winchurch
R A
RA
Huang
P C
PC
D000375:Aging; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000254:growth & development; D008099:Liver / Q000187:drug effects / Q000254:growth & development; D008297:Male; D008668:Metallothionein / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL / Q000254:growth & development*; D013737:Testis / Q000187:drug effects / Q000254:growth & development
D002104:Cadmium; D008668:Metallothionein; D019256:Cadmium Chloride