Short-term stimulation of lymphocyte proliferation by indomethacin in vitro and in vivo.
The effect of short-term (up to 24 h) in vitro and in vivo treatment with indomethacin was studied on the blastogenesis of mouse spleen cells. Indomethacin in itself induced a strong proliferation of the lymphocytes starting after 6 h treatment both in vitro and in vivo. Besides, significantly enhanced the blastogenesis of splenocytes in response to various doses of PHA and Con A. The stimulation of lectin-induced lymphocyte proliferation occurred after indomethacin treatment both in vitro and in vivo. Indomethacin had no major effect on the distribution of Lyt-1+ and Lyt-2+ subsets within the spleen cell population. An important role of the prostaglandins in the early phase of lymphocyte activation is suggested.
González-Cabello
R
R
Second Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
Perl
A
A
Kalmár
L
L
Gergely
P
P
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010641:Phenotype; D010835:Phytohemagglutinins / Q000494:pharmacology; D013154:Spleen / Q000166:cytology
D010835:Phytohemagglutinins; D003208:Concanavalin A; D007213:Indomethacin