[The phenomenon of "early and stimulated death" in mice infected and then vaccinated against rabies].
Live (diluted) and inactivated rabies vaccines of low antigen content induce early and enhanced death in mice, inoculated before vaccination with a wild type of rabies virus. Such vaccines, which neither induce interferon nor protect, produce a low level of antibodies which appear later than with vaccines of higher antigenicity. It is recommended to examine rabies vaccines not only by the usual (pre-exposure) potency test-NIH test or modified NIH test (one vaccination), but also by a post-exposure potency test.
Bijlenga
G
G
Ecole Nationale Vétérinaire de Lyon, Maladies Contagieuses, Charbonnières.
Ganeshwaran
A
A
Joubert
L
L
Lery
L
L
D000818:Animals; D003643:Death; D005260:Female; D051379:Mice; D011818:Rabies / Q000503:physiopathology*; D011819:Rabies Vaccines
D011819:Rabies Vaccines
Le phénomène de "mort précoce et stimulée" chez la souris infectée puis vaccinée contre la rage.