[Intra-arterial cis-platinum in the treatment of squamous cell carcinoma of the cervix].
Three patients with advanced cervical carcinoma were treated with two courses of cis-platinum (CDDP) intra-arterial administration. Histology of all patients revealed squamous cell carcinoma, keratinizing type, and all patients had stage IIIb diseases. CDDP at a dose of 50 mg was infused through each catheter of which tips were fixed in the bilateral internal iliac arteries via the opposite femoral arteries. The course of therapy was repeated at an interval of three to four weeks, so the total dose of CDDP in each patient was 200 mg. The bleeding from lesions, which occurred intermittently before therapy in all patients, was reduced after the primary course of therapy and completely stopped after the second one. Marked reduction of lesion on computed tomograph (CT) was confirmed in all patients. The reduction in the product of perpendicular diameters of measurable lesions on CT ranged from 40 to 50%. Adverse effects such as nephrotoxicity, myelosuppression and gastrointestinal toxicity were mild as compared with patients receiving intravenous administration of CDDP. The excellent clinical effects and tolerance observed in this study indicated that an intra-arterial administration of CDDP has a highly therapeutic efficacy in the treatment of squamous cell carcinoma of the cervix.
Dept. of Obstetrics and Gynecology, Aichi Medical University.
T
T
Okamoto
T
T
Masahashi
A
A
Ogawa
K
K
Higuchi
K
K
Sawaguchi
H
H
Yabushita
M
M
Noguchi
M
M
Ishihara
D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*
D002945:Cisplatin