[The role of the antioxidant system in the mechanism of adaptation to intensive noise].
It has been shown in the experiment with albino rats that the prolonged influence of stable noise (90 dB) results in a shift of the redox equilibrium in the thiol-disulphide and ascorbate systems of the adrenal gland and myocardium tissues towards oxidation and the activity of glucoso-6-phosphate dehydrogenase and superoxide dismutase decreases. A concept on the pathogenetic role of the redox equilibrium disturbance in the thiol-disulphide system, in particular, in the development of noise pathology is suggested.
Goncharova
L L
LL
Makarova
I N
IN
Kiseleva
N N
NN
Rodionova
L P
LP
D000222:Adaptation, Physiological; D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004220:Disulfides / Q000097:blood / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D009622:Noise / Q000009:adverse effects*; D010084:Oxidation-Reduction; D051381:Rats; D013438:Sulfhydryl Compounds / Q000097:blood / Q000378:metabolism
D000975:Antioxidants; D004220:Disulfides; D013438:Sulfhydryl Compounds
Rol' antioksidantnoĭ sistemy v mekhanizme adaptatsii organizma k vozdeĭstviiu intensivnogo shuma.