Aqueous humour concentration of metoprolol after oral administration.
The concentration of the beta-adrenergic blocking agent metoprolol was determined in the blood plasma and aqueous humour of two groups of subjects after oral administration of the compound. One group (8 cases) had received a single divided dose of metoprolol, whilst the other group (7 cases) was receiving chronic therapy with the drug. There was a tendency towards a higher concentration of metoprolol in the aqueous humour as compared to the blood plasma in the chronic treatment group in contrast to the 'single' dose group.
Calissendorff
B
B
Department of Ophthalmology, Karolinska Institute/Huddinge University Hospital, Sweden.
D000284:Administration, Oral; D001082:Aqueous Humor / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage / Q000378:metabolism*; D010865:Pilot Projects
D008790:Metoprolol