Facile exchange of the cyano group in highly potent anticancer cyanomorpholinyl anthracyclines.
Synthetic Medical Chemistry Department, SRI International Menlo Park, CA 94025.
J H
JH
Peters
G R
GR
Gordon
H W
HW
Nolen
M
M
Tracy
D W
DW
Thomas
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000378:metabolism*; D003486:Cyanides / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D007941:Leukemia P388 / Q000188:drug therapy; D013058:Mass Spectrometry; D051379:Mice; D009279:Naphthacenes / Q000378:metabolism / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D003486:Cyanides; D009279:Naphthacenes; D004247:DNA