[Bioavailability of heptaminol in healthy subjects].
In ten healthy volunteers the plasma and urine concentrations of heptaminol (Heptylon) were determined by high-performance liquid chromatography after intravenous administration of 250 mg heptaminol and oral intake of 2 x 150 mg heptaminol in tablet form, and the pharmacokinetic parameters were calculated. Heptaminol was rapidly and entirely absorbed following oral administration of heptaminol. Mean plasma peak concentrations of 1.6 mg/l were reached after 1.8 h, the area under the plasma concentration-time curve was equal to that after intravenous administration. The dominant terminal plasma half-life was 2.5-2.7 h. The total clearance amounted to 700 ml/min, and nearly all the dose given was recovered unchanged in urine within 24 h, indicating renal elimination by glomerular filtration and tubular secretion without metabolization.
Lehrstuhl für Pharmakologie der Universität Regensburg.
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F
Kees
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P
Dominiak
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H
Grobecker
D000284:Administration, Oral; D000328:Adult; D000605:Amino Alcohols / Q000493:pharmacokinetics*; D001682:Biological Availability; D002855:Chromatography, Thin Layer; D005260:Female; D006207:Half-Life; D006535:Heptaminol / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D008297:Male
D000605:Amino Alcohols; D006535:Heptaminol
Untersuchungen zur Bioverfügbarkeit von Heptaminol bei Probanden.