Creatine kinase BB activity in serum of patients with acute stroke: correlation with the severity of brain damage.
BB-CK activity was measured in 11 patients with stroke and in 10 controls. Blood samples were taken 36 hours after the clinical stroke onset in every patient. Sera were stored at -80 degrees and analyzed within two months. The creatine kinase isoenzymatic pattern was determined by ion-exchange column separation and gradient elution system. The mean BB-CK concentration in patients with stroke was significantly higher than in controls (p less than 0.01). In the group of "stroke" patients we found a correlation between severity of brain damage, as suggested by the clinical picture and CT scans, and serum values of BB-CK.
Istituto Malattie Nervose e Mentali, Università degli Studi di Perugia.
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Capocchi
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Tassi
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Ricci
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Zampolini
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Fausti
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Rossi
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001925:Brain Damage, Chronic / Q000201:enzymology; D002561:Cerebrovascular Disorders / Q000201:enzymology*; D002852:Chromatography, Ion Exchange; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D007527:Isoenzymes; D003402:Creatine Kinase