The use of ciprofloxacin in the treatment of patients with cystic fibrosis.
The use of ciprofloxacin for the treatment of pulmonary infection in cystic fibrosis patients was investigated. Therapy was successful in six patients and unsuccessful in three patients. In one patient therapy had to be stopped because serum transaminase levels showed a 5- to 8- fold increase. During therapy resistance developed in Haemophilus influenzae, Staphylococcus aureus and Pseudomonas aeruginosa.
Department of Infectious Diseases, University Hospital Building 1, Leiden, The Netherlands.
P J
PJ
van den Broek
W
W
Bakker
H
H
Mattie
C
C
van Gulpen
D000328:Adult; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy*; D004352:Drug Resistance, Microbial; D006192:Haemophilus Infections / Q000188:drug therapy; D006801:Humans; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy*; D011552:Pseudomonas Infections / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy
D002939:Ciprofloxacin