[Genetic factors predisposing to autoimmune diseases. Study of HLA antigens in a family with pernicious anemia and thyroid diseases].
In a family including patients suffering from autoimmune disease (2 propositi: pernicious anemia and Graves' disease, pernicious anemia and autoimmune thyroiditis), we have determined common autoantibodies and tissue antigens (HLA) in 47 patients (26 males and 21 females) from 2 generations. In this family, we have found 4 cases of pernicious anemia, 5 cases of thyroid disease (2 Graves' disease), 3 women with repetitive abortions and 2 cases of melanoma. Patients with autoantibodies, often asymptomatic, are abnormally numerous (44% in generation II, 16% in generation III). A correlation with haplotype A1B8DR3 was found only for Graves' disease. Likelihood of forming autoantibodies appears to be of multifactorial origin. Its mode of transmission remains unknown.
Petite
J
J
Service de médecine, Hôpital régional, Martigny.
Rosset
N
N
Chapuis
B
B
Jeannet
M
M
D000026:Abortion, Habitual / Q000235:genetics; D000328:Adult; D000368:Aged; D000752:Anemia, Pernicious / Q000235:genetics* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000235:genetics*; D002648:Child; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000145:classification; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics; D008875:Middle Aged; D010375:Pedigree; D011247:Pregnancy; D013959:Thyroid Diseases / Q000235:genetics* / Q000276:immunology
D001323:Autoantibodies; D006680:HLA Antigens
Facteurs génétiques prédisposant aux maladies auto-immunes. Etude des antigènes HLA dans une famille avec anémie pernicieuse et maladies thyroïdiennes.