5-Aminosalicylic acid as enemas or suppositories in distal ulcerative colitis?
Thirty-nine patients with documented active distal proctitis (less than 20 cm) received either 5-aminosalicylic acid (5-ASA) enemas (2 g in 100 ml) or suppositories 1 g b.i.d., in a controlled study. Twenty patients received enemas, while 19 patients received suppositories, for 30 days. No difference could be observed in terms of efficacy; however, it was the patients' opinion that treatment with suppositories was easier than that with enemas (p less than 0.01).
Istituto di Clinica Medica e Gastroenterologia, Universitá di Bologna, Policlinico S. Orsola, Italy.
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Campieri
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Gionchetti
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Belluzzi
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Brignola
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Tabanelli
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Miglioli
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Barbara
D000285:Administration, Rectal; D000636:Aminosalicylic Acids / Q000008:administration & dosage*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D004733:Enema; D006801:Humans; D019804:Mesalamine; D012646:Self Administration; D013488:Suppositories
D000636:Aminosalicylic Acids; D013488:Suppositories; D019804:Mesalamine