Phospholipids and fatty acid profile of brain synaptosomal membrane from normotensive and hypertensive rats.
1. The main synaptosomal membrane phospholipids and their acyl group profiles, from 3-4 month-old spontaneously hypertensive rats (SHR), were compared with those of age-matched normotensive Wistar Kyoto (WKY) rats. 2. The contents of the main or total phospholipids were not found to be significantly different between these two groups. It was also true for the membrane cholesterol contents in these two groups. 3. The acyl groups of the main phospholipids from hypertensive rats were significantly higher in the saturated fatty acids: such as palmitic acid or stearic acid, and lower in polyunsaturated fatty acids: such as undecylenic acid or docosahexaenoic acid, when compared to the corresponding normotensive controls. 4. The differences in the acyl group profile of the brain membrane phospholipids of the hypertensive rats seem to reflect an abnormality in the genetically related lipolytic process.
Neuroscience Institute, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China.
J W
JW
Wei
L M
LM
Yang
S H
SH
Sun
C L
CL
Chiang
D000818:Animals; D001923:Brain Chemistry; D002784:Cholesterol / Q000032:analysis; D005227:Fatty Acids / Q000032:analysis*; D006973:Hypertension / Q000378:metabolism*; D008563:Membrane Lipids / Q000032:analysis*; D010743:Phospholipids / Q000032:analysis*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013570:Synaptic Membranes / Q000032:analysis; D013574:Synaptosomes / Q000032:analysis*
D005227:Fatty Acids; D008563:Membrane Lipids; D010743:Phospholipids; D002784:Cholesterol