Double-blind evaluation of clonazepam on periodic leg movements in sleep.
Treatment with clonazepam was studied in a group of 20 patients suffering from periodic movements in sleep, in a double-blind parallel group design. Eleven complained of excessive daytime sleepiness, and nine complained of insomnia. Ten patients received clonazepam, and 10 received placebo, over a period of 1 month. Clonazepam (0.5-2 mg per night) proved to be an effective treatment of periodic movements in sleep. Polysomnographic recordings demonstrated a significant decrease in the number of leg movements and a significant improvement in sleep parameters in the clonazepam group as compared with placebo. Subjective responses to treatment corroborated the sleep laboratory findings.
Peled
R
R
Sleep Laboratory, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Lavie
P
P
D002998:Clonazepam / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D006801:Humans; D007866:Leg; D009068:Movement / Q000187:drug effects*; D012148:Restless Legs Syndrome / Q000188:drug therapy / Q000503:physiopathology; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy / Q000503:physiopathology; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000503:physiopathology
D002998:Clonazepam