Co-operativity in sodium-independent taurine binding to brain membranes in the mouse.
Sodium-independent taurine binding to mouse brain membranes treated twice with Triton X-100 exhibited properties of positive co-operativity, suggesting that two or more taurine molecules interact at the binding site. The proposed taurine antagonist 6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine-1,1-dioxide and the new anticonvulsant taurine derivative taltrimide as well as glycine and GABA with their antagonists displaced taurine binding, strychnine being the most effective.
Kontro
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Department of Biomedical Sciences, University of Tampere, Finland.
Oja
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D000818:Animals; D001581:Benzothiadiazines / Q000378:metabolism; D001667:Binding, Competitive; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D007700:Kinetics; D051379:Mice; D012964:Sodium / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism*; D013654:Taurine / Q000378:metabolism*
D001581:Benzothiadiazines; D013654:Taurine; C032946:6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide; D012964:Sodium