Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges.
Following a tolerance study, double-blind placebo controlled trials were conducted to determine the prophylactic effect of zinc gluconate lozenges on rhinovirus challenge and, in a third study, their therapeutic efficacy when given at the start of colds caused by virus inoculation was tested. In the prophylaxis study a total of 57 volunteers received lozenges of either zinc gluconate (23 mg) (29 volunteers) or matched placebo (28 volunteers) every 2 h while awake during a period of four and a half days. They were challenged with 10(2) tissue culture infecting dose (TCID50) of human rhinovirus 2 (HRV-2) on the second day of medication, and were monitored daily for symptoms and signs of colds and laboratory evidence of infection. Zinc reduced the total mean clinical score from 8.2 in the placebo group to 5.7 and the reduction of the mean clinical score was statistically significant on the second day after virus challenge. In the therapeutic study 69 volunteers were inoculated with 10(2) TCID50 of HRV-2 and those who developed cold symptoms were randomly allocated to receive either zinc gluconate lozenges (six volunteers) or matched placebo lozenges (six volunteers) every two hours they were awake for six days. Treatment of colds with zinc reduced the mean daily clinical score and this was statistically significant on the fourth and fifth day of medication. Similarly, medication also reduced the mean daily nasal secretion weight and total tissue count and these reductions were statistically significant on days two and six for nasal secretion weights and days four to six of medication for tissue counts when compared with placebo.(ABSTRACT TRUNCATED AT 250 WORDS)
MRC Common Cold Unit, Harvard Hospital, Salisbury, Wiltshire, U.K.
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W
Al-Nakib
P G
PG
Higgins
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I
Barrow
G
G
Batstone
D A
DA
Tyrrell
D000328:Adult; D003139:Common Cold / Q000188:drug therapy* / Q000517:prevention & control; D004311:Double-Blind Method; D005260:Female; D005942:Gluconates / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013607:Tablets; D013649:Taste / Q000187:drug effects; D015032:Zinc / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism
D005942:Gluconates; D013607:Tablets; D015032:Zinc; C030691:gluconic acid