[Changes in hepatocyte dehydrogenase activity in different zones of liver acini during the revascularization of ischemic extremities].
After ischemia (3, 6, 9 and 12 h) of the hind extremities in dogs with a subsequent revascularization for 2 h, enzymatic activity of hepatocytes changes. After ischemia for 3 h the enzymatic activity increases. Restoration of the blood flow at later stages of the experiment results in a progressive decrease of dehydrogenase and diaphorase activities. To a greater extend the changes of the enzymatic activity are observed in perivenular hepatocytes (in the 3d zone of the hepatic acinus).
O D
OD
Mishnev
A I
AI
Shchegolev
A P
AP
Raksha
D000818:Animals; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D004285:Dogs; D005121:Extremities / Q000098:blood supply*; D005260:Female; D006651:Histocytochemistry; D007511:Ischemia / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism*; D013997:Time Factors
D010088:Oxidoreductases; D008058:Dihydrolipoamide Dehydrogenase
Izmeneniia aktivnosti degidrogenaz gepatotsitov razlichnykh zon pechenochnykh atsinusov pri revaskuliarizatsii ishemizirovannykh konechnosteĭ.