Effect of ovariectomy in humans on serum 6-keto-PGF1 alpha and TXB2 concentrations and platelet fatty acids.
The effects of ovariectomy on serum 6-keto-PGF1 alpha and TXB2 concentrations and platelet fatty acids were investigated. One month after ovariectomy the levels of 6-keto-PGF1 alpha were unaltered, whereas those of TXB2 were significantly increased. Ovariectomy had no effect on the fatty acid composition of platelets. Thus, the present study suggests that the hormonal changes at the time of menopause may modify the formation of metabolites of arachidonic acid.
Punnonen
R
R
Seppälä
E
E
Punnonen
K
K
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D001792:Blood Platelets / Q000032:analysis*; D003327:Coronary Disease / Q000209:etiology; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D010052:Ovariectomy; D012306:Risk; D013929:Thromboxane B2 / Q000097:blood*
D005227:Fatty Acids; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha