Cellulose phosphate and chlorothiazide in childhood idiopathic hypercalciuria.
A calcium loading test performed on seven of eight children with idiopathic hypercalciuria identified the hyperabsorptive form of hypercalciuria in five and renal hypercalciuria in one. The type of hypercalciuria was not identified in the other patient. Three children presented with hematuria without calculus formation. Chlorothiazide reduced the urinary calcium excretion level in two of six patients to the normal range. The addition of cellulose phosphate to chlorothiazide reduced the urinary calcium excretion level to the normal range in those four patients who showed an incomplete response to chlorothiazide alone. There was clinical improvement with cellulose phosphate in another child whose symptoms did not disappear after chlorothiazide had reduced urinary calcium level to the normal range. Cellulose phosphate is effective in children with recurrent stone formation who have shown inadequate response to chlorothiazide.
Burke
J R
JR
Cowley
D M
DM
Mottram
B M
BM
Buckner
P
P
D000284:Administration, Oral; D002118:Calcium / Q000008:administration & dosage / Q000097:blood / Q000652:urine*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000652:urine; D002648:Child; D002675:Child, Preschool; D002740:Chlorothiazide / Q000627:therapeutic use* / Q000652:urine; D003404:Creatinine / Q000652:urine; D005215:Fasting; D006801:Humans; D007223:Infant; D014545:Urinary Calculi / Q000517:prevention & control / Q000652:urine
D002740:Chlorothiazide; D002482:Cellulose; C008881:phosphocellulose; D003404:Creatinine; D002118:Calcium