Diet and chronic atrophic gastritis: a case-control study.
A hospital-based case-control study of gastric cancer precursor lesions was conducted in a high-risk black population in southern Louisiana. Ninety-three subjects with biopsy-proved advanced chronic atrophic gastritis were compared to two control series: a gastroscopy clinic series and a general hospital-admission series. Dietary case-control differences indicated a protective effect associated with fruit and vegetable intake and with dietary vitamin C and a risk elevation associated with milk consumption. The protective effect associated with consumption of fruits, vegetables, and vitamin C is consistent with findings for gastric cancer and with the etiologic hypothesis of intragastric nitrosation. A twofold increased risk was associated with cigarette smoking. Gastric juice pH, NO3-, and NO2- were determined for subjects undergoing gastroscopy, and comparisons were made between this high-risk U.S. group and a Colombian population with a much greater magnitude of risk; the latter had higher NO3- and NO2- levels. An increase in pH was associated with increasing severity of gastric lesions. Levels of pH and NO2- concentration were significantly correlated (P less than .0005); however, in Louisiana the large difference in NO2- concentration associated with pH elevation is not associated with histopathologic severity. Divergent trends with severity of lesions for NO3- concentration were seen in the two populations.
Fontham
E
E
Zavala
D
D
Correa
P
P
Rodriguez
E
E
Hunter
F
F
Haenszel
W
W
Tannenbaum
S R
SR
D000328:Adult; D000367:Age Factors; D000368:Aged; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage; D044383:Black People; D002908:Chronic Disease; D004032:Diet; D005260:Female; D005638:Fruit; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000032:analysis; D005756:Gastritis / Q000209:etiology*; D005757:Gastritis, Atrophic / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008892:Milk; D009566:Nitrates / Q000032:analysis; D009573:Nitrites / Q000032:analysis; D012737:Sex Factors; D012907:Smoking; D012965:Sodium Chloride / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000209:etiology; D014675:Vegetables
D009566:Nitrates; D009573:Nitrites; D012965:Sodium Chloride; D001205:Ascorbic Acid