Glycosylated hemoglobins in a diabetic patient with sickle cell anemia.
Results of analysis of blood samples from a diabetic sickle cell anemia (SS) patient and 4 nondiabetic SS patients for glycosylated hemoglobins by Bio-Rex 70 chromatography, high-pressure liquid chromatography, and affinity chromatography are presented. Glycosylated components of Hb S and Hb A2 and total glycosylated hemoglobins were quantitated in this manner. The levels of the various glycosylated hemoglobins were increased twofold in the diabetic patient compared to nondiabetic SS patients. The glycosylated hemoglobin levels in the diabetic SS patient and in the nondiabetic SS patients, however, were significantly lower than the levels normally seen in nonsickle diabetics and normal adults, respectively. In contrast to a previously reported diabetic SS patient, the present case appears to be not severely affected by sickle cell disease.
Abraham
E C
EC
Department of Cell and Molecular Biology, Medical College of Georgia, Augusta.
Rao
K R
KR
D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male
D006442:Glycated Hemoglobin