Stability of solutions of doxorubicin and epirubicin in plastic minibags for intravesical use after storage at -20 degrees C and thawing by microwave radiation.
Doxorubicin and epirubicin solutions in plastic minibags for intravesical use were stored at -20 degrees C and thawed at room temperature or by microwave radiation. Concentrations were measured with HPLC and TLC. Doxorubicin and epirubicin solutions could be frozen and stored at -20 degrees C during at least two and four weeks, respectively, and subsequently thawed without loss of content. When the thawed doxorubicin solutions were refrozen and thawed again five weeks later, only a slight decrease of content was measured.
Keusters
L
L
Stolk
L M
LM
Umans
R
R
Van Asten
P
P
D004317:Doxorubicin / Q000032:analysis* / Q000528:radiation effects; D004349:Drug Packaging; D004356:Drug Storage; D015251:Epirubicin; D005615:Freezing; D007263:Infusions, Parenteral; D008872:Microwaves
D015251:Epirubicin; D004317:Doxorubicin