Experimental research on IGF-1.
IGF-1 has been produced by recombinant DNA technology; the host cell is a yeast. Studies in hypophysectomized rats show that IGF-1 has little growth promoting effect unless given by infusion at high doses, and priming with bovine growth hormone did not produce any potentiation. In vitro studies reveal that IGF-1 cross-reacts with the insulin receptor on adipose cells. Immunohistochemical studies have revealed high IGF-1 immunoreactivity in proliferating and differentiating cells in the testes, lymphoid organs and pancreatic islets and particularly in regenerating nerves. Local application of IGF-1 may stimulate regeneration in damaged peripheral nerves. Key words:
Skottner
A
A
Fryklund
L
L
Hansson
H A
HA
D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D006128:Growth / Q000187:drug effects; D006801:Humans; D007120:Immunochemistry; D066298:In Vitro Techniques; D007334:Insulin-Like Growth Factor I / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D009416:Nerve Regeneration / Q000187:drug effects; D051381:Rats; D011994:Recombinant Proteins / Q000276:immunology / Q000494:pharmacology; D013002:Somatomedins / Q000494:pharmacology*
D011994:Recombinant Proteins; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I