title: Extracorporeal methods of liver failure treatment.
abstract: A combination of plasma exchange and dialysis, the procedure of which is easily and safely performed by our hepatic assist system, composed of a membrane plasma separator, blood and plasma pumps, hemodialyzer and controller. This may be a practical and reliable method for hepatic support at the present time, however, the results are not so satisfactory. In order to improve our system, a surfactant-free polyolefine membrane plasma separator has been developed and evaluated to be better than conventional ones in both efficiency and biocompatibility. And also, a new module of IONEX, completely saturated with heparin, has been developed as a safe and an efficient adsorbent, which selectively adsorb bilirubin and bile acids.
authors.affiliation: 2nd Department of Surgery, University of Tokyo, Japan.
authors.forename: Z
authors.initials: Z
authors.lastname: Yamazaki
authors.forename: F
authors.initials: F
authors.lastname: Kanai
authors.forename: Y
authors.initials: Y
authors.lastname: Idezuki
authors.forename: N
authors.initials: N
authors.lastname: Inoue
mesh_terms: D000208:Acute Disease; D000327:Adsorption; D000328:Adult; D000368:Aged; D000818:Animals; D001647:Bile Acids and Salts / Q000302:isolation & purification; D001663:Bilirubin / Q000302:isolation & purification; D006348:Cardiac Surgical Procedures; D004285:Dogs; D004731:Endotoxins / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000401:mortality / Q000628:therapy*; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010951:Plasma Exchange / Q000295:instrumentation*; D010969:Plastics; D011090:Polyenes; D011183:Postoperative Complications / Q000628:therapy; D006435:Renal Dialysis
chemical_list: D001647:Bile Acids and Salts; D004731:Endotoxins; D008567:Membranes, Artificial; D010969:Plastics; D011090:Polyenes; C035051:PL 732; D001663:Bilirubin