title: Chromosomal localization of human gene for histidyl-tRNA synthetase: clustering of genes encoding aminoacyl-tRNA synthetases on human chromosome 5.
abstract: The gene encoding histidyl-tRNA synthetase was localized to human chromosome 5 using human-Chinese hamster ovary cell hybrids. Seven of the functionally related genes encoding the 20 different aminoacyl-tRNA synthetases have not been mapped in humans and four are located on a single chromosome, number 5, which represents less than 7% of the total genome. Thus, there appears to be significant clustering of this group of genes which may reflect their evolutionary relatedness or common factors involved in regulating their expression.
authors.forename: J J
authors.initials: JJ
authors.lastname: Wasmuth
authors.forename: L R
authors.initials: LR
authors.lastname: Carlock
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D006224:Cricetinae; D003412:Cricetulus; D005796:Genes; D005819:Genetic Markers; D006643:Histidine-tRNA Ligase / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D007621:Karyotyping
chemical_list: D005819:Genetic Markers; D000604:Amino Acyl-tRNA Synthetases; D006643:Histidine-tRNA Ligase