[Pharmacokinetics of high-dose cisplatin administration (relationship between pharmacokinetics and administration schedule)].
Three cases of urogenital malignancy were treated with 80-120/m2 of cisplatin by a 0.5-hour (rapid) or 4-hour (slow) infusion. Each patient received three courses of repeated chemotherapy. The kinetics of total platinum was measured up to 48 hours in the blood and urine. The blood peak concentrations were achieved 6.0 micrograms/ml by rapid infusion, 2.0 micrograms/ml by slow infusion. The time dependent urinary excretion rate against total administered dose was 40% in 60 min. by rapid infusion, 20% in 16 hours by slow infusion. The volume of distribution correlated with infusion time. Rapid infusion way of cisplatin could be better to treat the patient with bulky tumor mass or patients with uroepithelial cancer like CIS, because a higher blood and urine concentration can be obtained than by slow infusion.
Yamamoto
N
N
Department of Pharmacology, School of Medicine, Yamaguchi University.
Yanagi
K
K
Matuyama
H
H
Shimizu
K
K
Mitsui
H
H
Shimabukuro
T
T
Yamamoto
M
M
Sakatoku
J
J
Fujita
T
T
Matsuoka
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D014565:Urogenital Neoplasms / Q000188:drug therapy / Q000378:metabolism
D002945:Cisplatin