title: Four documented cases of eosinophilic meningoencephalitis due to Angiostrongylus cantonensis in Hong Kong.
abstract: 4 cases of eosinophilic meningoencephalitis in Hong Kong are described. The major clinical features of the patients, who were 2-60 years old, were low grade fever, headache, mild meningeal signs, right facial palsy or hemiplegia. Eosinophilia in the peripheral blood and eosinophilic pleocytosis were prominent. Computerized tomography scans of brain showed a small area of attenuation with surrounding hypodense area; the lesion was resolved 1-2 months after admission to hospital. Electroencephalograms revealed abnormally slow dysrhythmia. Sections of a nematode observed in the brain of a patient who died were identified as those of young adult Angiostrongylus cantonensis. High ELISA titres against the crude antigens of this nematode were also noted in the serum of 3 patients. The disease is probably under-recognized in Hong Kong.
authors.affiliation: Dept of Zoology, University of Hong Kong.
authors.forename: R C
authors.initials: RC
authors.lastname: Ko
authors.forename: S W
authors.initials: SW
authors.lastname: Chan
authors.forename: K W
authors.initials: KW
authors.lastname: Chan
authors.forename: K
authors.initials: K
authors.lastname: Lam
authors.forename: M
authors.initials: M
authors.lastname: Farrington
authors.forename: H W
authors.initials: HW
authors.lastname: Wong
authors.forename: P
authors.initials: P
authors.lastname: Yuen
mesh_terms: D000328:Adult; D000801:Angiostrongylus / Q000302:isolation & purification; D000818:Animals; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D004802:Eosinophilia / Q000453:epidemiology / Q000209:etiology / Q000469:parasitology*; D005260:Female; D006723:Hong Kong; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000453:epidemiology / Q000209:etiology / Q000469:parasitology*; D008875:Middle Aged; D009349:Nematode Infections / Q000150:complications*