Influence of ethnic diets on ampicillin bioavailability and pharmacokinetics in healthy Pakistani subjects.
The influence of time and different ethnic diets on relative bioavailability and pharmacokinetics of orally administered ampicillin was studied in healthy Pakistani subjects. The bioavailability of ampicillin was determined using the plasma levels which were measured microbiologically. Plasma levels were analyzed, assuming a one-compartment linear model with first order absorption. Different types of Pakistani diets ingested immediately before dosing reduced plasma levels to an almost similar extent, while different results were found upon changing the time of drug administration with respect to the food intake. The study reveals that, for maximum absorption, ampicillin should be given on empty stomach and at least 1.5 h before the meal.
Hamid
S
S
Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Pakistan.
Beg
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D000328:Adult; D000667:Ampicillin / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D004032:Diet; D005006:Ethnicity; D006801:Humans; D008297:Male; D010154:Pakistan
D000667:Ampicillin