Cytogenetic analysis of a gossypol-induced murine myxosarcoma.
Cytogenetic analysis of gossypol acetate-induced murine myxosarcoma demonstrated a stemline of 78 chromosomes and the presence of three marker (M) chromosomes produced by robertsonian translocation. Tumor cells at passage 1 that contain chromosomes M1 and M2 were nontumorigenic, whereas cells at passage 3 were tumorigenic in syngeneic mice and showed M1, M2, and M3. The presence of M3 has been implicated to be responsible for the tumorigenic phenotype.
Dhaliwal
M K
MK
Norman
J O
JO
Pathak
S
S
Busbee
D L
DL
D000818:Animals; D002875:Chromosomes; D005260:Female; D006072:Gossypol; D007621:Karyotyping; D008297:Male; D051379:Mice; D009236:Myxosarcoma / Q000139:chemically induced / Q000235:genetics*; D012509:Sarcoma / Q000235:genetics*; D014178:Translocation, Genetic
D006072:Gossypol