Karyotype evolution in CML: high frequency of translocations other than the Ph.
The karyotypes of 33 Philadelphia-positive chronic myelogenous leukemia patients during the blastic phase are reported. Only three patients (9%) had a Philadelphia clone without further chromosomal aberrations, whereas, all the others had karyotype evolution. Aside from some nonrandom abnormalities (+8, i(17q), +Ph, +19) we found a higher frequency of clones with random structural rearrangements (13 cases, 39.4%) than previously reported. From a clinical point of view, however, the additional chromosomal (structural) abnormalities do not significantly influence the patients' survival.
Sessarego
M
M
Panarello
C
C
Coviello
D A
DA
Boccaccio
P
P
Ajmar
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D001752:Blast Crisis; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic
D005819:Genetic Markers