Studies on the reliability of a bihyperbolic functional absorption model. II. Phenylalkylamines.
Evidence is given that demonstrates the reliability of the bihyperbolic equation, proposed by Plá-Delfina and Moreno, in fitting the correlation between absorption rate constants (ka) found in the small intestine and in the colon of the living anesthetized rat, and partition constants (1/RF-1), for a series of phenylalkylamines, a group of compounds which differ largely from others which have been tested. Emphasis is laid on the nonexistence of an optimum of lipophilicity for intestinal absorption/partition correlation: This feature makes inapplicable the probabilistic approaches to the reported data.
Casabó
V G
VG
Department of Pharmaceutics, Faculty of Pharmacy, University of Valencia, Spain.
Núñez-Benito
E
E
Martínez-Coscollá
A
A
Miralles-Loyola
E
E
Martín-Villodre
A
A
Plá-Delfina
J M
JM
D000814:Aniline Compounds / Q000493:pharmacokinetics*; D000818:Animals; D001596:Benzylamines / Q000493:pharmacokinetics; D002082:Butylamines / Q000493:pharmacokinetics; D007408:Intestinal Absorption; D008297:Male; D008954:Models, Biological; D010627:Phenethylamines / Q000493:pharmacokinetics; D011437:Propylamines / Q000493:pharmacokinetics; D011619:Psychotropic Drugs / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains
D000814:Aniline Compounds; D001596:Benzylamines; D002082:Butylamines; D010627:Phenethylamines; D011437:Propylamines; D011619:Psychotropic Drugs; C029261:phenethylamine; C030796:benzylamine