Effect of olsalazine sodium on migrating motor complexes in the upper small bowel of human volunteers.
The effect of a peroral dose of olsalazine sodium on the migrating motor complexes (MMC) in the upper small bowel was studied by manometry in nine healthy volunteers during fasting. Recordings were obtained from the duodenum and/or the upper jejunum for 4.0 - 7.5 h. During total baseline observation periods of 30 h, fourteen MMCs could be identified compared to ten complexes during post dose registrations of 25 h. This gives an average mean interval for baseline pre dose complexes of 2.2 h, and for post dose complexes 2.5 h. If excluding the two subjects, who had the longest interval until the first MMC before dosing and did not present any MMC after dosing, the corresponding figures are 1.9 h and 1.9 h, respectively. Although our material is small with respect to the large individual variation in the recordings the results indicate that MMC does occur after an olsalazine sodium dose which is twice the dose normally recommended. Besides we can conclude that there is no apparent interference with the time for MMC occurrence in the upper small bowel in fasting humans.
Ryde
M
M
Department of Human Pharmacology, Pharmacia AB, Uppsala University Hospital, Sweden.
Gustavsson
S
S
D000284:Administration, Oral; D000328:Adult; D000636:Aminosalicylic Acids / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007421:Intestine, Small / Q000187:drug effects*; D008297:Male; D008875:Middle Aged
D000636:Aminosalicylic Acids; C028836:N-acetyl-5-aminosalicylic acid; C032587:olsalazine