Ofloxacin: concentration in human ejaculate and influence on sperm motility.
The concentration of ofloxacin was measured in both fractions of split-ejaculate from five volunteers treated with ofloxacin 400 mg/day for 3.5 consecutive days. Concentrations in both fractions were equal, 2.44 mg/l and 2.5 mg/l, respectively indicating that the penetration of ofloxacin into the prostate gland and into the vesical glands are of the same magnitude. Sperm motility was not affected by ofloxacin in a concentration of 4.5 mg/l as tested on fresh ejaculate of 29 andrologic patients. Thus ofloxacin proves to be useful as a potent antibiotic in clinical care for andrologic patients.
Schramm
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D000328:Adult; D000890:Anti-Infective Agents / Q000032:analysis* / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008297:Male; D015242:Ofloxacin; D010078:Oxazines / Q000032:analysis* / Q000378:metabolism / Q000494:pharmacology; D011467:Prostate / Q000378:metabolism; D012661:Semen / Q000032:analysis*; D012669:Seminal Vesicles / Q000378:metabolism; D013081:Sperm Motility / Q000187:drug effects*; D014018:Tissue Distribution
D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin