Relationship between the cellular composition of sputum and the cytologic diagnosis of lung cancer.
In 410 patients with either a primary or a metastatic malignant lung process, the cellular composition of the sputum specimens was analyzed in relation to the diagnostic accuracy of sputum cytology and in relation to anamnestic and clinical patient characteristics. In patients with primary lung cancer, sputum samples with true-positive cytologic diagnoses contained significantly more cells from the deeper airways, such as alveolar macrophages and bronchial columnar cells, than did sputum specimens with a false-negative diagnosis, even though these cell types were present in both types of specimens. In sputum samples from patients with metastatic lung malignancies, differences in cellular composition of specimens with true-positive and false-negative diagnoses were not significant.
Risse
E K
EK
Vooijs
G P
GP
van't Hof
M A
MA
D002452:Cell Count; D003581:Cytodiagnosis; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000556:secondary; D008264:Macrophages; D011237:Predictive Value of Tests; D013183:Sputum / Q000166:cytology*