title: Genetic analysis of the proximal portion of the mouse t complex: evidence for a second inversion within t haplotypes.
abstract: Genomic sequences derived from the mouse t complex by a microdissection cloning technique have been used as tools to obtain high resolution genetic maps of the wild-type and t haplotype forms of the most proximal portion of chromosome 17. Genetic mapping was performed through a recombinant inbred strain analysis and an analysis of partial t haplotypes. The accumulated data demonstrate the existence of a large inversion of genetic material, encompassing the loci of T and qk, within the proximal portion of t haplotypes. This newly described proximal inversion and the previously described distal inversion provide an explanation for the suppression of recombination observed along the length of t haplotype DNA in heterozygous mice.
authors.forename: B
authors.initials: B
authors.lastname: Herrmann
authors.forename: M
authors.initials: M
authors.lastname: Bućan
authors.forename: P E
authors.initials: PE
authors.lastname: Mains
authors.forename: A M
authors.initials: AM
authors.lastname: Frischauf
authors.forename: L M
authors.initials: LM
authors.lastname: Silver
authors.forename: H
authors.initials: H
authors.lastname: Lehrach
mesh_terms: D000818:Animals; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D005819:Genetic Markers; D006579:Heterozygote; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009154:Mutation; D011995:Recombination, Genetic
chemical_list: D005819:Genetic Markers