A comparison of the contractile activity of PGD2 and PGF2 alpha on human isolated bronchus.
Prostaglandins may be implicated in the bronchoconstriction which occurs in asthma. Prostaglandins F2 alpha (PGF2 alpha) and D2 (PGD2) have been reported to produce bronchoconstriction in asthmatic subjects in vivo and PGF2 alpha contracts human isolated airway smooth muscle. We examined the relative efficacy and potency of PGF2 alpha and PGD2 on human bronchial spiral strips taken from 6 patients at thoracotomy. PGF2 alpha had greater efficacy than PGD2. The mean % Tmax (percentage of maximal contractile response) +/- s.e. mean were 84 +/- 7 and 54 +/- 7 respectively (P less than 0.05). PGF2 alpha (mean pD2 +/- s.e. mean = 6.39 +/- 0.6) tended to be more potent than PGD2 (5.68 +/- 0.2). Since, in vivo, PGD2 has greater efficacy and potency than PGF2 alpha, our results suggest that the in vivo effect of these prostaglandins does not result solely from an action on airway muscle.
Black
J L
JL
Armour
C L
CL
Vincenc
K S
KS
Johnson
P R
PR
D001980:Bronchi / Q000187:drug effects* / Q000502:physiology / Q000503:physiopathology; D015237:Dinoprost; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*
D011457:Prostaglandins D; D011460:Prostaglandins F; D015237:Dinoprost; D015230:Prostaglandin D2