[Effect of acute hypervitaminosis A on serum concentrations of Na, K, Mg, Fe, Zn and Cu in rats].
The effect of hypervitaminosis A on the content of sodium, potassium, magnesium, iron, zinc and copper in rat serum was studied. Results were compared to findings in non-treated animals. The serum content of potassium, magnesium and copper increased significantly, while the content of sodium, zinc and iron decreased significantly in the treated animals, when compared to the values obtained with untreated animals. Possible mechanisms for these changes are discussed, and we conclude that high doses of vitamin A cause a marked change in the serum content on the measured cations.
Alarcón
O M
OM
Departamento de Bioqímica, Facultad de Medicina, Universidad de Los Andes, Mérida, Venezuela.
Burguera
J L
JL
Burguera
M
M
D000208:Acute Disease; D000818:Animals; D003300:Copper / Q000097:blood; D004231:Diuresis / Q000187:drug effects; D006986:Hypervitaminosis A / Q000097:blood*; D007501:Iron / Q000097:blood; D008107:Liver Diseases / Q000097:blood / Q000473:pathology; D008274:Magnesium / Q000097:blood; D008297:Male; D008670:Metals / Q000097:blood*; D011188:Potassium / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000097:blood; D014801:Vitamin A / Q000032:analysis / Q000494:pharmacology; D015032:Zinc / Q000097:blood
D008670:Metals; D014801:Vitamin A; D003300:Copper; D012964:Sodium; D007501:Iron; D008274:Magnesium; D015032:Zinc; D011188:Potassium
Efecto de la hipervitaminosis A aguda sobre las concentraciones séricas de Na, K, Mg, Fe, Zn y Cu en ratas.