Microbial transformation of azacarbazoles. VI. Conversion of 6-hydroxy- and 6-amino-alpha-carbolines with copper oxidases.
alpha-Carboline substituted at C-6 with hydroxy-group is oxidized by human ceruloplasmin and fungal laccase into reactive intermediate which dimerizes, while 6-amino-alpha-carboline subjected to action of both enzymes yields the polymeric products. To prepare sufficient quantities of compounds needed for structure elucidation studies, laccase, immobilised in polyacrylamide gel was employed as a convenient reagent. The resulting products are suggested to be metabolities of 6-hydroxy- and 6-amino-alpha-carbolines formed in vivo.
Peczyńska-Czoch
W
W
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
D001711:Biotransformation; D002243:Carbolines / Q000493:pharmacokinetics*; D002570:Ceruloplasmin / Q000378:metabolism; D042845:Laccase; D010088:Oxidoreductases / Q000378:metabolism*; D011124:Polyporaceae / Q000378:metabolism
D002243:Carbolines; C055571:alpha-carboline; D010088:Oxidoreductases; D042845:Laccase; C024748:copper oxidase; D002570:Ceruloplasmin