[Stimulation and inhibition of the growth of mice carrying the human growth hormone gene].
The human growth hormone gene, containing mouse metallothionein gene promotor, was injected into the male pronuclei of fertilized mouse ova. The progeny of transgenic mice included animals with both accelerated and inhibited growth. Radioimmunochemical analysis has revealed human growth hormone synthesis in both groups of transgenic mice. The molecular weight of the hormone synthesized in liver cells was 25,000 daltons. A possible mechanisms of foreign hormone effect on the growth of transgenic mice is discussed.
Gorodetskiĭ
S I
SI
Dyban
A P
AP
Vaĭsman
B L
BL
Golinskiĭ
G F
GF
Popkova
G A
GA
D000818:Animals; D004247:DNA / Q000235:genetics; D005260:Female; D005786:Gene Expression Regulation; D005818:Genetic Engineering; D006128:Growth; D013006:Growth Hormone / Q000235:genetics*; D006801:Humans; D008297:Male; D008668:Metallothionein / Q000235:genetics; D051379:Mice; D008845:Microinjections; D011401:Promoter Regions, Genetic; D014170:Transformation, Genetic
D013006:Growth Hormone; D004247:DNA; D008668:Metallothionein
Stimuliatsiia i tormozhenie rosta mysheĭ, nesushchikh gen gormona rosta cheloveka.