Effect of Rumex nepalensis extracts on histamine, acetylcholine, carbachol, bradykinin, and PGs evoked skin reactions in rabbits.
The antihistaminic, anticholinergic, antibradykinin, and/or antiprostaglandin activity of aqueous and the alcoholic leaf extracts of the plant Rumex nepalensis were tested on the prepared site on the back of rabbits, using a control and a test site. Aqueous extract was found to reduce the mean size of the wheal produced by histamine, acetylcholine, carbachol, and bradykinin. The alcoholic extract reduced the size of the wheal produced by histamine, acetylcholine and carbachol. The results indicate that Rumex nepalensis may have antihistaminic, anticholinergic, and/or antibradykinin activity.
Aggarwal
P K
PK
Kumar
L
L
Garg
S K
SK
Mathur
V S
VS
D000109:Acetylcholine / Q000276:immunology*; D000527:Alprostadil / Q000276:immunology; D000698:Analgesia; D000758:Anesthesia; D000818:Animals; D001920:Bradykinin / Q000276:immunology*; D002217:Carbachol / Q000276:immunology*; D015237:Dinoprost; D015232:Dinoprostone; D005260:Female; D006632:Histamine / Q000276:immunology*; D006969:Hypersensitivity, Immediate / Q000276:immunology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011453:Prostaglandins / Q000276:immunology*; D011458:Prostaglandins E / Q000276:immunology; D011460:Prostaglandins F / Q000276:immunology; D011817:Rabbits; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests
D010936:Plant Extracts; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D006632:Histamine; D002217:Carbachol; D015237:Dinoprost; D000527:Alprostadil; D015232:Dinoprostone; D000109:Acetylcholine; D001920:Bradykinin