In vitro effect of isotretinoin on monocyte chemotaxis.
The effect of isotretinoin on the chemotaxis of human monocytes was studied in an in vitro system using a Nucleopore chamber. The chemoattractant used was zymosan-activated serum. Inhibition of monocyte chemotaxis was achieved with isotretinoin in concentrations of 1 X 10(-3) M and 5 X 10(-4) M. It is felt that the improvement seen in patients with inflammatory skin diseases such as cystic acne and acne conglobata who are treated with isotretinoin may in part be a result of this anti-inflammatory action.
Falcon
R H
RH
Lee
W L
WL
Shalita
A R
AR
Suntharalingam
K
K
Fikrig
S M
SM
D000328:Adult; D002465:Cell Movement / Q000187:drug effects; D002630:Chemotactic Factors / Q000502:physiology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D005260:Female; D006801:Humans; D015474:Isotretinoin; D008264:Macrophages; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000502:physiology*; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D014212:Tretinoin / Q000494:pharmacology*; D015054:Zymosan
D002630:Chemotactic Factors; D012710:Serum Albumin, Bovine; D014212:Tretinoin; D015054:Zymosan; D015474:Isotretinoin