Platelet hyperaggregability in cystic fibrosis.
Platelet function was investigated in 15 patients with cystic fibrosis (CF) and in ten age-matched controls. Marked hyperaggregability of platelets to adrenaline, collagen and arachidonic acid was observed in platelet rich plasma (PRP) prepared from patients with cystic fibrosis. Thromboxane A2 (TXA2) release from these platelets was also markedly enhanced. Hyperaggregability and increased TXA2 release observed in patients with CF was not due to the higher platelet counts in these patients since hyperaggregability was observed even in those patients whose platelet counts were similar to those in controls. Platelet hyperaggregability and increased thromboxane release in these patients were also independent of their body weight and occurred despite supplementation with vitamin E. Hyperaggregability of platelets in CF may be clinically relevant since it may contribute to the pathogenesis of bronchoconstriction through the release of TXA2 and other bronchoconstrictor platelet products such as serotonin.
Stead
R J
RJ
Barradas
M A
MA
Mikhailidis
D P
DP
Jeremy
J Y
JY
Hodson
M E
ME
Batten
J C
JC
Dandona
P
P
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D003550:Cystic Fibrosis / Q000097:blood* / Q000150:complications; D005228:Fatty Acids, Essential / Q000172:deficiency; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation; D010976:Platelet Count; D013928:Thromboxane A2 / Q000097:blood / Q000378:metabolism; D014811:Vitamin E Deficiency / Q000150:complications
D005228:Fatty Acids, Essential; D013928:Thromboxane A2