Dosage of the Sts gene in the mouse.
In this study we compared steroid sulfatase levels in XO, XX, and XY mice and carried out a clonal analysis in fibroblast cell cultures from mice heterozygous for the steroid sulfatase deficiency gene and heterozygous at the X-linked electrophoretic phosphoglycerate kinase locus. The combined results indicate that the murine steroid sulfatase locus is not dosage compensated and is not subject to X-inactivation. With respect to X-inactivation, it behaves in a somewhat different way from the closely linked sex-reversed gene and the human steroid sulfatase locus.
Keitges
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Gartler
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SM
D000483:Alleles; D000818:Animals; D004303:Dosage Compensation, Genetic; D005260:Female; D008040:Genetic Linkage; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000235:genetics*; D014960:X Chromosome; D014998:Y Chromosome
D013429:Sulfatases; D043266:Steryl-Sulfatase