[Effect of imipenem/cilastatin sodium in thirty cases of bone and joint infection].
Thirty cases of bone and joint infections were treated by a chemotherapy with imipenem/cilastatin sodium (MK-0787/MK-0791). An overall curative rate was 87%. It was 96% in cases of acute inflammatory state and 50% in cases of chronic state. Thirteen cases received surgical intervention with chemotherapy and showed complete healing, but curative rate of 16 cases without surgery was 76%. Twenty strains of microorganisms were isolated and identified from these patients. The MIC of MK-0787 against S. aureus was as small as less than or equal to 0.012 to 0.024 micrograms/ml to a 10(6)/ml suspension. Thus antibacterial action of MK-0787 was very strong. The MIC against E. coli was 0.20 micrograms/ml. Incidence of adverse reactions was small as only in two cases occurred slight nausea. Laboratory examinations of blood, liver and kidney function found no influence of the drug.
Sakurai
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M
D000328:Adult; D000368:Aged; D001170:Arthritis, Infectious / Q000188:drug therapy*; D001424:Bacterial Infections / Q000188:drug therapy; D002062:Bursitis / Q000188:drug therapy; D002648:Child; D015377:Cilastatin; D003131:Combined Modality Therapy; D003521:Cyclopropanes / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D015378:Imipenem; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy*; D052256:Tendinopathy / Q000188:drug therapy; D013845:Thienamycins / Q000008:administration & dosage*
D003521:Cyclopropanes; D004338:Drug Combinations; D013845:Thienamycins; D015377:Cilastatin; D015378:Imipenem