title: Biochemical and morphometric analysis of the effect of spironolactone on the livers from immature and adult rats.
abstract: Biochemical and morphometric studies were carried out to characterize the effect of spironolactone (SP) on liver tissue from immature and adult young rats: 1. The SP produced an increase in total protein in all the groups. 2. Hypertrophy in 24 days-old rats. 3. Hypertrophy and hyperplasia in 48 days-old rats. 4. The morphometric studies were correlated to the biochemical parameters.
authors.affiliation: Instituto de Fisiologia Experimental, Conicet, Universidad Nacional de Rosario, Argentina.
authors.forename: E E
authors.initials: EE
authors.lastname: Guibert
authors.forename: J V
authors.initials: JV
authors.lastname: Rodriguez
authors.forename: G
authors.initials: G
authors.lastname: Garcia
authors.forename: E A
authors.initials: EA
authors.lastname: Rodriguez Garay
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D003593:Cytoplasm / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D046911:Macromolecular Substances; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013148:Spironolactone / Q000494:pharmacology*
chemical_list: D046911:Macromolecular Substances; D013148:Spironolactone