[Acute leukemia secondary to idiopathic myelofibrosis with homozygote pseudo-Pelger anomaly and complex chromosomal changes].
The Authors present a case of acute myeloblastic leukemia secondary to a busulfan and splenic radiotherapy treated idiopathic myelofibrosis. The presence of D group complex chromosomal abnormalities could be responsible for the simultaneous massive Pelger anomaly of granulocytes.
Tosato
F
F
Fossaluzza
V
V
Bortotto
L
L
Bartolomei
P
P
D000368:Aged; D002066:Busulfan / Q000009:adverse effects; D002869:Chromosome Aberrations; D002901:Chromosomes, Human, 13-15; D005260:Female; D006720:Homozygote; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics; D010381:Pelger-Huet Anomaly / Q000175:diagnosis* / Q000235:genetics; D055728:Primary Myelofibrosis / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D013154:Spleen / Q000528:radiation effects
D002066:Busulfan
Leucemia acuta secondaria a mielofibrosi idiopatica con pseudo-Pelger omozigote ed alterazioni cromosomiche complesse.