title: Childhood acute lymphoblastic leukemia presenting as "cold" lesions on bone scan: a report of two cases.
abstract: "Cold" lesions on bone scan have been reported in a variety of disease processes, including infection, avascular necrosis, and cysts. We present two cases of children who presented with large "cold" areas on technetium bone scans and were treated initially for septic processes. Acute childhood leukemia frequently presents with bone or joint pain, fever, and elevation of the erythrocyte sedimentation rate. Although the diagnosis may be difficult if the characteristic clinical signs and laboratory findings are absent, the presence of anemia should alert the physician to the possibility of malignancy. Bone scanning provides a sensitive method of localizing pathology, but diagnosis requires biopsy or marrow aspiration.
authors.forename: R J
authors.initials: RJ
authors.lastname: Caudle
authors.forename: A H
authors.initials: AH
authors.lastname: Crawford
authors.forename: M J
authors.initials: MJ
authors.lastname: Gelfand
authors.forename: R A
authors.initials: RA
authors.lastname: Gruppo
mesh_terms: D001170:Arthritis, Infectious / Q000000981:diagnostic imaging; D001853:Bone Marrow / Q000473:pathology; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004164:Diphosphonates; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D010019:Osteomyelitis / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D013667:Technetium; D017556:Technetium Compounds
chemical_list: D004164:Diphosphonates; D017556:Technetium Compounds; D013667:Technetium; C029045:technetium Tc 99m diphosphonate