Antimicrobial activity of U-70138F (paldimycin), roxithromycin (RU 965), and ofloxacin (ORF 18489) against Chlamydia trachomatis in cell culture.
The MICs of three new antimicrobial agents of different classes, U-70138F, roxithromycin (RU 965), and ofloxacin (ORF 18489), versus Chlamydia trachomatis in McCoy cell cultures were 0.25, 0.8, and 1.0 microgram/ml, respectively. For each test drug, the MIC and MBC were identical or were within 1 dilution of one another. These drugs possessed sufficient activity in cell culture to suggest possible clinical effectiveness.
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D000111:Acetylcysteine / Q000031:analogs & derivatives; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D002692:Chlamydia trachomatis / Q000187:drug effects*; D004187:Disaccharides; D006020:Glycopeptides / Q000494:pharmacology*; D007933:Leucomycins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D004187:Disaccharides; D006020:Glycopeptides; D007933:Leucomycins; D010078:Oxazines; D015242:Ofloxacin; C050461:paldimycin; D000111:Acetylcysteine