title: Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.
abstract: The human major histocompatibility complex (MHC) includes the closely linked genes for the tumor necrosis factors alpha and beta. Their location is within the chromosomal segment between HLA-DR and HLA-A or centromeric of HLA-DP. This assignment is based on Southern blot analysis of a number of different MHC deletion mutants and is corroborated by chromosome in situ hybridization.
authors.forename: T
authors.initials: T
authors.lastname: Spies
authors.forename: C C
authors.initials: CC
authors.lastname: Morton
authors.forename: S A
authors.initials: SA
authors.lastname: Nedospasov
authors.forename: W
authors.initials: W
authors.lastname: Fiers
authors.forename: D
authors.initials: D
authors.lastname: Pious
authors.forename: J L
authors.initials: JL
authors.lastname: Strominger
mesh_terms: D002872:Chromosome Deletion; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis; D006023:Glycoproteins / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex; D014409:Tumor Necrosis Factor-alpha
chemical_list: D006023:Glycoproteins; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D014409:Tumor Necrosis Factor-alpha; D004247:DNA