In vitro study of the antibiotic activity of diterpenes.
The antibiotic activity of 16 diterpenes and of 2 phenanthrene derivatives of diterpene origin, isolated from Brazilian plants was investigated against bacteria, yeasts, dermatophytes and aflatoxin-producing fungi. Eight of the compounds were completely inactive. None showed inhibitory activity against the Gram-negative bacteria assayed or against the Aspergillus species. The phenanthrene derivatives, chemically very similar to phytoalexins isolated from orchids, were especially active.
Giesbrecht
A M
AM
Departamento de Farmacologia, Universidade de São Paulo, Brasil.
Davino
S C
SC
Barbosa
R C
RC
Paula
C R
CR
D001419:Bacteria / Q000187:drug effects*; D001938:Brazil; D055598:Chemical Phenomena; D002621:Chemistry; D004224:Diterpenes / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D010616:Phenanthrenes / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D015003:Yeasts / Q000187:drug effects*
D004224:Diterpenes; D010616:Phenanthrenes; D010936:Plant Extracts