An immunohistochemical study of lymphocyte subsets and expression of glandular HLA-DR in labial salivary glands from patients with symptomatic xerostomia, rheumatoid arthritis and systemic lupus erythematosus.
Lymphocyte subsets, T+6 cells and glandular expression of HLA-DR within labial salivary glands from patients with symptomatic xerostomia (n = 9), RA (n = 24) and SLE (n = 25) were studied using an immunoperoxidase method and monoclonal antibodies. The results indicate that common immune cellular reactions are involved in glandular changes irrespective of patient group and that the appearance of T+6 cells and glandular expression of HLA-DR are unlikely to play a role in initiation of lymphoid infiltration.
Matthews
J B
JB
Potts
A J
AJ
Hamburger
J
J
Scott
D G
DG
Struthers
G
G
D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000473:pathology*; D006681:HLA-D Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000473:pathology*; D008214:Lymphocytes / Q000145:classification*; D012469:Salivary Glands / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000276:immunology / Q000473:pathology*; D014987:Xerostomia / Q000276:immunology / Q000473:pathology*
D006681:HLA-D Antigens; D006684:HLA-DR Antigens