title: Therapeutic modalities for central nervous system involvement by granulocytic sarcoma (chloroma) in children with acute nonlymphocytic leukemia.
abstract: Four cases of central nervous system involvement by granulocytic sarcoma (three intracranial and one paraspinal) in children with acute nonlymphocytic leukemia (FAB M1 or M2 subtype) are presented, and therapeutic modalities are discussed. All tumors were noted at initial presentation with diagnosis being made on clinical and radiological findings without biopsy. All patients had karyotypic abnormalities: three had translocation of chromosomes 8 and 21, and one had an unspecified hypodiploid clone. The three patients who developed intracranial tumors responded well to triple agent (cytosine arabinoside, hydrocortisone, and methotrexate) intrathecal chemotherapy and systemic chemotherapy, with or without local irradiation, as evidenced by rapid disappearance of the tumors. Two children are disease-free after 17 and 57 months. One patient with paraspinal tumor failed to achieve a systemic remission but had no evidence of granulocytic sarcoma at autopsy. Thus, the prognosis of CNS granulocytic sarcoma is not uniformly gloomy if treated aggressively by combined modalities. The value of surgical intervention in terms of primary management, however, is limited.
authors.forename: Y
authors.initials: Y
authors.lastname: Takaue
authors.forename: S J
authors.initials: SJ
authors.lastname: Culbert
authors.forename: T
authors.initials: T
authors.lastname: Baram
authors.forename: A
authors.initials: A
authors.lastname: Cork
authors.forename: J M
authors.initials: JM
authors.lastname: Trujillo
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000209:etiology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D003131:Combined Modality Therapy; D006801:Humans; D007938:Leukemia / Q000150:complications*; D007951:Leukemia, Myeloid / Q000209:etiology / Q000628:therapy*; D012189:Retrospective Studies; D013125:Spinal Neoplasms / Q000209:etiology / Q000628:therapy