The possibilities of the automated morphometry in the diagnosis of the hyperlipoproteidemia. Morphometry in the diagnosis of the hyperlipoproteidemias.
Following are the results of using the elaborated algorhythms of the structural analysis for the study of the form elements of the blood. A possibility was demonstrated to carry out a differential diagnosis of the familial hyperlipoproteidemia of the second type according to the quantitative structural parametres of the chromatin of the inter-phase nuclei of the lymphocytes of the peripheral blood. A method was developed of the automated morphometry of erythrocytes making it possible to assess the optical profile of erythrocytes according to 16 parametres. It was also registered a more vivid change of the curve of the membrane of the erythrocytes as compared with the Price-Jones spread on the same erythrocytes. With a help of a system of proposed parametres, which are 4-6-fold more informative and sensitive, than the traditional ones, it is possible to obtain the qualitatively new characteristics of the forms of erythrocytes, and not only their sizes.
Zhukotsky
A V
AV
Scientific Research Institute of Physico-Chemical Medicine, Ministry of Public Health of the Russian Federation, Moscow.
Butusova
N N
NN
Umudov
K M
KM
Kogan
E M
EM
D002843:Chromatin / Q000648:ultrastructure; D003581:Cytodiagnosis / Q000379:methods*; D004912:Erythrocytes / Q000648:ultrastructure; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D007399:Interphase; D008214:Lymphocytes / Q000648:ultrastructure
D002843:Chromatin