Sex differences in the effect of uric acid on the survival of analbuminemic rats exposed to cold: effects of gonadal hormones and uric acid.
When female analbuminemic rats were injected with 0.8 mg uric acid every 3 h, their survival time at 5 degrees C increased from 14 h to 28 h, but uric acid had no effect on analbuminemic male rats. When female rats were oophorectomized 1 week before cold exposure, the injection of uric acid had no effect on their survival. Furthermore, uric acid did not increase the survival of the female rats that were administered a pellet containing 5 mg testosterone 1 week before the cold exposure. When the male rats were castrated 1 week before cold exposure, their survival time decreased from 20 h to 14 h, and administrations of 5 mg estradiol pellet at the time of castration and 0.8 mg uric acid every 3 h during cold exposure increased their survival time to 23 h.
Kawaguchi
T
T
Department of Physiology, Wakayama Medical College, Japan.
Shimode
M
M
Matsushita
H
H
Nagase
S
S
D000818:Animals; D002369:Castration; D003080:Cold Temperature / Q000009:adverse effects*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics; D012709:Serum Albumin / Q000172:deficiency*; D012727:Sex Characteristics; D013739:Testosterone / Q000494:pharmacology; D014527:Uric Acid / Q000494:pharmacology*
D012739:Gonadal Steroid Hormones; D012709:Serum Albumin; D014527:Uric Acid; D013739:Testosterone; D004958:Estradiol