Motility and drug susceptibility of Angiostrongylus cantonensis developing from gamma-irradiated first-stage larvae.
The effects of neuropharmacological agents on the motility of irradiated and non-irradiated Angiostrongylus cantonensis adult females were studied. GABA induced complete paralysis in non-irradiated and 5,000 R-irradiated worms, but caused only slight paralysis on 10,000 R-irradiated worms. The paralytic effect of GABA was antagonised by picrotoxin. The reason for low susceptibility of heavily irradiated worms to GABA is not known. There was no difference in susceptibility of non-irradiated and irradiated worms to other neuropharmacological agents including eserine, phenylephrine and dibenamine.
Ishii
A I
AI
Department of Parasitology, Hamamatsu University School of Medicine, Japan.
Terada
M
M
Sano
M
M
D000801:Angiostrongylus / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D000818:Animals; D001337:Autonomic Agents / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology*; D003983:Dibenzylchlorethamine / Q000494:pharmacology; D005260:Female; D005720:Gamma Rays; D007814:Larva / Q000528:radiation effects; D008297:Male; D008681:Metastrongyloidea / Q000528:radiation effects*; D009068:Movement / Q000187:drug effects; D010656:Phenylephrine / Q000494:pharmacology; D010830:Physostigmine / Q000031:analogs & derivatives / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013331:Strychnine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D001337:Autonomic Agents; D003292:Convulsants; D003983:Dibenzylchlorethamine; D010656:Phenylephrine; D010830:Physostigmine; D010852:Picrotoxin; D013331:Strychnine; D005680:gamma-Aminobutyric Acid; C026718:physostigmine salicylate