Phialophora verrucosa-induced subcutaneous phaeohyphomycosis. Fine needle aspiration findings.
A 34-year-old woman on immunosuppressive therapy presented with a subcutaneous, cystic lesion on the dorsum of the right foot. Cytologic examination of material obtained by fine needle aspiration (FNA) revealed a mixture of acute and granulomatous inflammation as well as brown-pigmented fungi in the form of budding yeast, pseudohyphae and septate hyphae. The findings suggested subcutaneous phaeohyphomycosis (phaeomycotic cyst). Culture grew Phialophora verrucosa. The cytologic, histologic and cultural findings are given. This case demonstrates that phaeohyphomycosis can be diagnosed by FNA but that fungal culture is necessary to establish the identity of the etiologic agent. This appears to be the first case of P. verrucosa-induced subcutaneous phaeohyphomycosis reported in the Western Hemisphere.
Schnadig
V J
VJ
Long
E G
EG
Washington
J M
JM
McNeely
M C
MC
Troum
B A
BA
D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000328:Adult; D001707:Biopsy, Needle; D003881:Dermatomycoses / Q000139:chemically induced / Q000382:microbiology / Q000473:pathology*; D005260:Female; D005534:Foot Diseases / Q000139:chemically induced / Q000473:pathology*; D006801:Humans; D010676:Phialophora / Q000302:isolation & purification; D012507:Sarcoidosis / Q000188:drug therapy
D000305:Adrenal Cortex Hormones