title: [The role of CEA, CA 19-9 and TPA in the diagnosis of pancreatic cancer. Evaluation by discriminant analysis].
abstract: In order to assess the relative value of CA 19-9, Tissue Polypeptide Antigen (TPA) and Carcinoembryonic Antigen (CEA), evaluated alone and in combination, in diagnosing pancreatic malignancy, serum CA 19-9, TPA and CEA were determined in 25 control subjects (CS), 26 pancreatic cancer (PC), 23 chronic pancreatitis (CP) and 21 benign extra-pancreatic diseases (EPD). The three markers were able to allocate the subjects correctly in 56.8% of the cases (CS 100%, PC 73.1%, CP 17.4%, EPD 28.6%). Sensitivity, specificity and diagnostic accuracy in detecting pancreatic cancer were respectively: 77%, 91% and 68% for CA 19-9; 92%, 75% and 67% for TPA; 50%, 84% and 34% for CEA; 73%, 91% and 64% for the three parameters evaluated simultaneously. CA 19-9 and TPA appear to be useful indices of pancreatic cancer with a satisfactory specificity when related to chronic pancreatitis; their diagnostic value seems to be comparable and better than that of CEA; the combination of these markers does not improve the results obtained by CA 19-9 or TPA alone.
authors.forename: D
authors.initials: D
authors.lastname: Basso
authors.forename: C
authors.initials: C
authors.lastname: Fabris
authors.forename: G
authors.initials: G
authors.lastname: Del Favero
authors.forename: A
authors.initials: A
authors.lastname: Panucci
authors.forename: A
authors.initials: A
authors.lastname: Piccoli
authors.forename: M
authors.initials: M
authors.lastname: Plebani
authors.forename: S
authors.initials: S
authors.lastname: Pedrazzoli
authors.forename: U
authors.initials: U
authors.lastname: Baccaglini
authors.forename: M
authors.initials: M
authors.lastname: Lise
authors.forename: A
authors.initials: A
authors.lastname: Burlina
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000276:immunology*; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000276:immunology*; D010455:Peptides / Q000276:immunology*; D019396:Tissue Polypeptide Antigen
chemical_list: D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen; D010455:Peptides; D019396:Tissue Polypeptide Antigen
vernacular_title: Ruolo del CEA, CA 19-9 e TPA nella diagnosi di carcinoma pancreatico. Valutazione con l'analisi discriminante.