title: Protection of gastric mucosa in rats. Differences between vagotomy, atropine, and PGE2.
abstract: We have studied the protective effects of truncal vagotomy, atropine, and PGE2 against gastric mucosal injury produced by necrotizing agents (0.2 N NaOH, 0.6 N HCl, absolute ethanol), acetylsalicylic acid (ASA) and HCl, or serotonin (5HT). Vagotomy, atropine, and PGE2 prevent the effects of different noxious agents. Vagotomy is protective only against 5HT and against ASA + 0.15 N or 0.35 N HCl, whereas atropine and PGE2 are also protective against the necrotizing agents. The effectiveness of vagotomy against ASA + 0.35 N HCl does not depend on the inhibition of acid secretion and supports the hypothesis that removal of the vagal drive counteracts the effect of H+ back-diffusion.
authors.forename: D
authors.initials: D
authors.lastname: Foschi
authors.forename: F
authors.initials: F
authors.lastname: Ferrante
authors.forename: L
authors.initials: L
authors.lastname: Varin
authors.forename: P
authors.initials: P
authors.lastname: Del Soldato
authors.forename: V
authors.initials: V
authors.lastname: Rovati
mesh_terms: D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology*; D001681:Biological Assay; D015232:Dinoprostone; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D005753:Gastric Mucosa / Q000032:analysis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D011458:Prostaglandins E / Q000032:analysis / Q000494:pharmacology*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology; D012972:Sodium Hydroxide / Q000494:pharmacology; D014628:Vagotomy
chemical_list: D011458:Prostaglandins E; D012701:Serotonin; D000431:Ethanol; D012972:Sodium Hydroxide; D001285:Atropine; D015232:Dinoprostone; D001241:Aspirin