Vancomycin-induced neutropenia complicating bone marrow recovery in a patient with leukemia. Case report and review of the literature.
Neutropenia associated with intravenous vancomycin therapy is reported in a patient with chronic myelogenous leukemia. The patient received 12 days of vancomycin therapy without incidence; however, a second course of vancomycin initiated on hospital day 14 produced severe neutropenia. This delayed onset is typical of vancomycin-induced neutropenia. The neutropenia reversed, without complications, as soon as the vancomycin was discontinued.
Mordenti
J
J
Ries
C
C
Brooks
G F
GF
Unadkat
N
N
Tseng
A
A
D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D007263:Infusions, Parenteral; D007951:Leukemia, Myeloid / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008802:Mezlocillin / Q000008:administration & dosage; D009503:Neutropenia / Q000139:chemically induced*; D014031:Tobramycin / Q000008:administration & dosage; D014640:Vancomycin / Q000009:adverse effects*
D014640:Vancomycin; D008802:Mezlocillin; D014031:Tobramycin