title: Congenital monoblastic leukemia cutis. A case report with chromosomal abnormality: del (10p).
abstract: Congenital monoblastic leukemia cutis is a rare disorder. We report an infant who developed infiltrative skin lesions by 2 weeks of age, which, when biopsied at 4 1/2 months of age revealed a monoblastic infiltrate. Blasts in the peripheral blood were not seen until 1 week before her death at 8 months of age. Chromosomal analyses of her bone marrow showed an abnormal clone of cells with a 46,XX,del(10)(p12) karyotype. Although chromosome 10 is rarely involved in hematologic malignancies, abnormalities of this chromosome within the region 10p11-10p13 have now been shown in four of 10 reported cases of congenital monoblastic leukemia.
authors.forename: I S
authors.initials: IS
authors.lastname: Seo
authors.forename: W A
authors.initials: WA
authors.lastname: McGuire
authors.forename: N A
authors.initials: NA
authors.lastname: Heerema
authors.forename: L D
authors.initials: LD
authors.lastname: Mirkin
authors.forename: R M
authors.initials: RM
authors.lastname: Weetman
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000151:congenital* / Q000235:genetics; D012878:Skin Neoplasms / Q000151:congenital* / Q000235:genetics / Q000648:ultrastructure