[Effect of vitamin C (V.C) on thermal sensitivity of Lewis tumor].
In this paper, the effect of V.C on thermal sensitivity of the tumor and normal tissues was studied. Average peak reaction and RD50 (50% reaction dosage) were used to evaluate the effect of V.C on thermal sensitivity of the normal tissue. Tumor cure rate and TCD50 (50% tumor cure dosage) were used to evaluate the effect of V.C on that of the tumor tissue. In all mice injected by V.C locally, the average peak reaction markedly increased, RD50 decreased by 1-2 fold; the tumor cure rate was obviously elevated, TCD50 was significantly reduced except those treated by 20' hyperthermia. TGF (therapeutic gain factor) was 1.76. These results indicate that V.C can increase the thermal sensitivity of tumor and normal tissues but the effect on tumor tissue is selective.
Yang
T N
TN
Affiliated Hospital, Tianjin Medical College.
Ren
C F
CF
Pan
H Q
HQ
Wang
J L
JL
Zhang
Z Y
ZY
Su
C H
CH
D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D005260:Female; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000628:therapy*
D001205:Ascorbic Acid