title: Antithrombotic activity of BN 50341, a structurally new compound with anticalcic and PAF-antagonistic properties.
abstract: BN 50341, a new benzazepine derivative, which has been shown to possess a mild anticalcic activity decreased (oral or i.v. administration) and also totally reversed (local superfusion) the in vivo electrically induced thrombus formation in rat or guinea-pig artery. These effects of BN 50341 were correlated with an inhibition of PAF-acether- and thrombin-induced platelet activation since it decreased free cytoplasmic calcium mobilization measured on cells loaded with the fluorescent probe Quin 2. Taking into account the beneficial effects of BN 50341 on vascular spasm as well as on the early stage of the process of white thrombus formation, this drug could be of therapeutic interest.
authors.forename: A
authors.initials: A
authors.lastname: Etienne
authors.forename: N
authors.initials: N
authors.lastname: Baroggi
authors.forename: R
authors.initials: R
authors.lastname: Andries
authors.forename: F
authors.initials: F
authors.lastname: Clostre
authors.forename: A
authors.initials: A
authors.lastname: Esanu
authors.forename: R
authors.initials: R
authors.lastname: Bourgain
authors.forename: P
authors.initials: P
authors.lastname: Braquet
mesh_terms: D000284:Administration, Oral; D000634:Aminoquinolines; D000818:Animals; D001011:Aorta / Q000187:drug effects; D001552:Benzazepines / Q000494:pharmacology* / Q000627:therapeutic use; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D002118:Calcium / Q000032:analysis / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003593:Cytoplasm / Q000378:metabolism; D005343:Fibrinolytic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006168:Guinea Pigs; D007275:Injections, Intravenous; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control
chemical_list: D000634:Aminoquinolines; D001552:Benzazepines; D002121:Calcium Channel Blockers; D005343:Fibrinolytic Agents; D010972:Platelet Activating Factor; C051269:BN 50341; C035739:Quin2; D002118:Calcium