Polymorphonuclear leukocyte functions in patients with acute rheumatic fever and rheumatic heart disease.
Polymorphonuclear (PMN) cell function was assessed in 30 children with active rheumatic fever (ARF) (Group I), 30 cases with active rheumatic heart disease (RHD) (Group II), 28 cases of ARF and RHD in remission (Group III) and 34 adults with quiescent RHD along with their age matched controls. All the groups showed normal spontaneous and chemotactic movement. Phagocytosis of yeast particles was significantly reduced in groups II (P less than 0.0005), III (P less than 0.025) and IV (P less than 0.005). The opsonic activity of disease sera was low in all 4 groups (P less than 0.0005). The intracellular metabolic activity was moderately elevated in Group III. Phagocytosis and opsonic activity were thus persistently low in all the groups including the remission and quiescent group.
Naik
S
S
Department of Pathology, Seth G.S. Medical College, Bombay, India.
Jambotkar
S
S
Kamat
J R
JR
Joshi
M K
MK
Kandoth
P W
PW
Kinare
S G
SG
D000293:Adolescent; D000328:Adult; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D002648:Child; D006801:Humans; D009504:Neutrophils / Q000276:immunology* / Q000502:physiology; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D009895:Opsonin Proteins / Q000276:immunology; D010587:Phagocytosis; D012213:Rheumatic Fever / Q000276:immunology* / Q000503:physiopathology; D012214:Rheumatic Heart Disease / Q000276:immunology* / Q000503:physiopathology
D009895:Opsonin Proteins; D009580:Nitroblue Tetrazolium