Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13----q23 region of chromosome 5.
We have used hamster cDNA probes for 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase (HMGCR) to determine the chromosomal location of the human gene for HMG CoA reductase. Southern blot analysis of genomic DNA from 16 independent mouse-human somatic cell hybrids showed that the human gene for HMG CoA reductase resides on chromosome 5. Analysis of Chinese hamster-human somatic cell hybrids selectively retaining human 5 or a portion of it showed that the gene locus for HMG CoA reductase can be assigned to the q13----q23 region of chromosome 5.
Mohandas
T
T
Heinzmann
C
C
Sparkes
R S
RS
Wasmuth
J
J
Edwards
P
P
Lusis
A J
AJ
D000818:Animals; D002478:Cells, Cultured; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002905:Chromosomes, Human, 4-5; D004247:DNA / Q000235:genetics; D004587:Electrophoresis, Agar Gel; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics*; D051379:Mice
D004247:DNA; D006903:Hydroxymethylglutaryl CoA Reductases