Trisomy 9 in hematologic disorders: possible association with primary thrombocytosis.
Ten patients with a hematologic disorder and a clone of cells with trisomy 9 in the bone marrow were studied in order to investigate the clinical significance of this chromosome anomaly. In five of the patients, trisomy 9 was the only anomaly; in four, there was also trisomy 8; and in one, a Y chromosome was also lacking. Four patients had a myelodysplastic syndrome, and six had a myeloproliferative disorder. Interestingly, four patients had primary thrombocytosis.
Cournoyer
D
D
Noël
P
P
Schmidt
M A
MA
Dewald
G W
GW
D000328:Adult; D000368:Aged; D002871:Chromosome Banding; D002899:Chromosomes, Human, Pair 9; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D009196:Myeloproliferative Disorders / Q000235:genetics*; D013922:Thrombocytosis / Q000235:genetics*; D014314:Trisomy
D005819:Genetic Markers