title: Enoxacin-warfarin interaction: pharmacokinetic and stereochemical aspects.
abstract: The interaction between the new quinoline-azaquinoline antibiotic enoxacin and the oral anticoagulant warfarin was investigated in six healthy male volunteers. Enoxacin was found not to affect the hypoprothrombinemic response produced by warfarin but did produce a decrease in the clearance of the less pharmacologically potent enantiomer of warfarin, (R)-warfarin. The decreased clearance of (R)-warfarin produced by concomitant enoxacin administration was found to be a consequence of inhibition by enoxacin of the (R)-6-hydroxywarfarin metabolic pathway.
authors.forename: S
authors.initials: S
authors.lastname: Toon
authors.forename: K J
authors.initials: KJ
authors.lastname: Hopkins
authors.forename: F M
authors.initials: FM
authors.lastname: Garstang
authors.forename: L
authors.initials: L
authors.lastname: Aarons
authors.forename: A
authors.initials: A
authors.lastname: Sedman
authors.forename: M
authors.initials: M
authors.lastname: Rowland
mesh_terms: D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D015365:Enoxacin; D006801:Humans; D007700:Kinetics; D008297:Male; D009287:Naphthyridines / Q000378:metabolism*; D011517:Prothrombin Time; D011897:Random Allocation; D013237:Stereoisomerism; D014859:Warfarin / Q000097:blood / Q000378:metabolism*
chemical_list: D009287:Naphthyridines; D015365:Enoxacin; D014859:Warfarin