[Delayed post-transfusional hemolysis, leukemoid syndrome, autoimmune hemolytic anemia. Coordinating Committee for the Specific Study of Anemias under the chairmanship of H. Rochant].
We report an observation relating to a history of dissociated pancytopenia with unexpected severe hemolysis following surgery for colonic carcinoma. Following short-term monochemotherapy with 5-fluorouracil investigations revealed neutropenia and leukemoid syndrome. The anemia probably resulted from the interaction of 2 consecutive mechanisms: delayed post-transfusional hemolysis through anamnestic alloimmunization and an autoimmune hemolytic anemia whose biological evidence persisted for several months after the initial episode.
D000741:Anemia, Aplastic / Q000139:chemically induced; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications*; D001327:Autoimmune Diseases / Q000209:etiology; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000601:surgery*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007955:Leukemoid Reaction / Q000150:complications*; D008875:Middle Aged; D011183:Postoperative Complications; D065227:Transfusion Reaction
D005472:Fluorouracil
Hémolyse retardée post-transfusionnelle, syndrome leucémoïde, anémie hémolytique auto-immune. Comité de coordination pour l'Exploration Spécifique des Anémies (CESA) sous la responsabilité de H. Rochant.