Transplantability and sensitivity to natural killer cells of aclarubicin-resistant murine lymphoma.
DBA/2 mice implanted i.p. with an aclarubicin (ACR)-resistant subline of L5178Y cells survived 4- to 5-fold longer than those with the parental cells; and animals with the Adriamycin- or bleomycin-resistant subline displayed an intermediate survival period. The i.p. treatment of mice with cyclophosphamide markedly enhanced i.p. growth of the ACR-resistant cells, suggesting that a certain host defense mechanism participates in the lower transplantability. In vitro, the ACR-resistant subline showed much higher sensitivity to natural killer cells. The i.p. pretreatment with anti-asialo-GM1 antibody markedly reduced the mean survival period of mice implanted i.p. with the ACR-resistant cells, suggesting that natural killer cells play an important role in the defense against transplantation of the ACR-resistant cells.
Sugimoto
Y
Y
Hirakawa
Y
Y
Tanaka
N
N
Tahara
M
M
Sato
I
I
Nishimura
T
T
Suzuki
H
H
Tanaka
N
N
D015250:Aclarubicin; D000818:Animals; D000937:Antigen-Antibody Reactions; D003520:Cyclophosphamide / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004351:Drug Resistance; D005677:G(M1) Ganglioside; D006028:Glycosphingolipids / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D007694:Killer Cells, Natural / Q000276:immunology*; D007940:Leukemia L5178 / Q000276:immunology* / Q000473:pathology; D007942:Leukemia, Experimental / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008811:Mice, Inbred DBA; D009279:Naphthacenes / Q000494:pharmacology; D009368:Neoplasm Transplantation
D006028:Glycosphingolipids; D009279:Naphthacenes; D005677:G(M1) Ganglioside; C018835:asialo GM1 ganglioside; D015250:Aclarubicin; D003520:Cyclophosphamide