The effects of ageing on aminopyrine and caffeine breath tests in the rat.
The influence of ageing on demethylation of 14C-aminopyrine (AP) and 14C-caffeine (Caf) in Wistar littermate rats was studied serially using the 14CO2-breath test. In both sexes, the elimination half-life (t1/2) of 14C-AP fell from a mean of approximately 75 min when weaned at 17 days to 45 min at maturity (49 days); thereafter t1/2 became prolonged, being most prolonged (82 min) in elderly male rats (210 days). Similarly, t1/2 of 14C-Caf was also prolonged with ageing. These studies using in vivo and longitudinal techniques indicate the importance of ageing on hepatic demethylation.
Feely
J
J
Department of Pharmacology and Therapeutics, Trinity College, Dublin, Ireland.
Kelleher
P
P
Odumosu
A
A
D000375:Aging / Q000378:metabolism*; D000632:Aminopyrine / Q000378:metabolism*; D000818:Animals; D001944:Breath Tests; D002110:Caffeine / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D008137:Longitudinal Studies; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D000632:Aminopyrine; D002110:Caffeine