Ofloxacin: therapeutic activity in experimental infections.
The therapeutic activity of ofloxacin, a new oral fluoroquinolone antibacterial agent, was tested in experimental infections in rodents. Its activity was compared with that of nalidixic acid, norfloxacin, amoxicillin and cotrimoxazole in Pseudomonas aeruginosa pyelonephritis in the rat, and with that of amikacin and cefotaxime in Proteus morganii thigh infections in mice. Ofloxacin proved to be more effective than reference drugs, even if parenterally administered, in reducing the bacterial count in muscle, kidney and urine.
Guerra
L
L
Erani
E
E
Xerri
L
L
D000284:Administration, Oral; D000380:Agranulocytosis / Q000150:complications; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D008297:Male; D051379:Mice; D015242:Ofloxacin; D010078:Oxazines / Q000008:administration & dosage / Q000627:therapeutic use*; D011512:Proteus Infections / Q000150:complications / Q000188:drug therapy*; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011704:Pyelonephritis / Q000188:drug therapy*; D051381:Rats
D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin