Association of aspirin-sensitive asthma with HLA-DQw2.
Patients with ASA-sensitive asthma form a clinically homogeneous subgroup of asthmatics characterized by nonatopic eosinophilia, sinusitis, nasal polyps, and frequent steroid dependency. Twenty-six Caucasian patients with ASA-sensitive asthma and 22 Caucasian patients with uncomplicated asthma were typed for HLA Class I and II antigens. A significant increase in HLA-DQw2 (relative risk, 4.06) was found in ASA-sensitive asthmatics. Asthmatic patients who were not ASA-sensitive had HLA frequencies that did not differ significantly from healthy Caucasian control subjects. These findings suggest that ASA-sensitive asthma represents a disease entity unique from other forms of asthma. Presumably, DQw2 or an associated genetic factor is involved in the pathogenesis of ASA-sensitive asthma.
Mullarkey
M F
MF
Thomas
P S
PS
Hansen
J A
JA
Webb
D R
DR
Nisperos
B
B
D001241:Aspirin; D001249:Asthma / Q000139:chemically induced* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000276:immunology*; D006680:HLA Antigens / Q000145:classification; D006683:HLA-DQ Antigens; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans
D006680:HLA Antigens; D006683:HLA-DQ Antigens; D000949:Histocompatibility Antigens Class II; D001241:Aspirin