title: Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22.
abstract: In order to determine on which chromosome the gene controlling human cytochrome P-450 (debrisoquine/sparteine type) is located a linkage study of polymorphic sparteine oxidation (PSO) to various polymorphic markers was carried out. Positive information for linkage between PSO and the P1 blood group was obtained with a maximal LOD-score of LOD = 3.35 for both male and female recombination fraction estimates of theta m = theta f = 0.0. The P1 blood group has been recently mapped to the long arm of chromosome 22. Thus it can be concluded that the gene controlling human cytochrome P-450 (debrisoquine/sparteine) is situated on the long arm of chromosome 22 in close vicinity to P1.
authors.forename: M
authors.initials: M
authors.lastname: Eichelbaum
authors.forename: M P
authors.initials: MP
authors.lastname: Baur
authors.forename: H J
authors.initials: HJ
authors.lastname: Dengler
authors.forename: B O
authors.initials: BO
authors.lastname: Osikowska-Evers
authors.forename: G
authors.initials: G
authors.lastname: Tieves
authors.forename: C
authors.initials: C
authors.lastname: Zekorn
authors.forename: C
authors.initials: C
authors.lastname: Rittner
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D003647:Debrisoquin / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010127:P Blood-Group System / Q000235:genetics; D013034:Sparteine / Q000378:metabolism
chemical_list: D005819:Genetic Markers; D010127:P Blood-Group System; D013034:Sparteine; D003577:Cytochrome P-450 Enzyme System; D003647:Debrisoquin