A possible diurnal variation in trazodone clearance.
Diurnal variations in drug metabolism that have clinical consequences have been described for several drugs used in internal medicine but have not been reported for antidepressants. The long half-lives of most antidepressants may obscure such variations. Trazodone hydrochloride has a short half-life compared with other commercially available antidepressants. The authors measured serum levels of trazodone 11 hours after both 9 a.m. and 9 p.m. equal doses of the medication in individuals who had been on these doses for more than 3 days. For patients on other medications in addition to trazodone, serum levels were significantly higher at 8 a.m. than at 8 p.m. (N = 7, P less than 0.01) and approached significance for patients on trazodone alone (N = 8, P = 0.06). Induction of hepatic microsomal enzymes by the other medications may have exaggerated the tendency for trazodone to show diurnal variations in serum levels.
Baxter
L R
LR
Wilkins
J N
JN
Smith
G B
GB
D000293:Adolescent; D000328:Adult; D000368:Aged; D002940:Circadian Rhythm; D003866:Depressive Disorder / Q000188:drug therapy; D001068:Feeding and Eating Disorders / Q000188:drug therapy; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D014196:Trazodone / Q000378:metabolism* / Q000627:therapeutic use
D014196:Trazodone