Antimicrobial activity of imipenem and SCH34343 against Legionella species.
Twenty-seven Legionella spp. strains were tested against four beta-lactams, erythromycin and rifampin by a buffered ACES-yeast extract broth microdilution method. The minimum concentrations inhibiting 90% of strains were imipenem 0.06 micrograms/ml, SCH34343 0.25 micrograms/ml, amoxicillin 0.5 micrograms/ml, cefotaxime less than or equal to 0.12 micrograms/ml, erythromycin 0.25 micrograms/ml, and rifampin less than or equal to 0.008 micrograms/ml.
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D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D015378:Imipenem; D007769:Lactams; D007875:Legionella / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D012293:Rifampin / Q000494:pharmacology; D013845:Thienamycins / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D007769:Lactams; D013845:Thienamycins; D004917:Erythromycin; D015378:Imipenem; D000658:Amoxicillin; C044617:Sch 34343; D002439:Cefotaxime; D012293:Rifampin