Hexose transport control in a fibroblast metabolic mutant can be promoted more effectively by D-allose than by glucose.
By studying the energy-requiring control of the hexose transport system (the transport "curb") in a lung fibroblast mutant called the phosphoglucose isomerase mutant (because it is devoid of the enzyme phosphoglucose isomerase) the following features were noted. The aldohexose D-allose, if added over 20 hr to a culture of the mutant, promotes the development of an intense curb of the hexose transport system, greatly surpassing that brought about by incubation with glucose. The allose-mediated curb can be circumvented by various metabolic inhibitors as well as by the presence of other aldohexoses such as mannose.
Ullrey
D B
DB
Kalckar
H M
HM
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D005347:Fibroblasts / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology*; D007700:Kinetics; D008168:Lung; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D009154:Mutation; D013379:Substrate Specificity
D009004:Monosaccharide Transport Proteins; C002055:allose; D005947:Glucose