Hematogenous origin of brain macrophages: a case report.
Del Río-Hortega believed that phagocytic cells in the CNS arise from microglia; however, recent autoradiographic studies have suggested a hematogenous origin for brain macrophages. To clarify this issue, we studied a young man with acute lymphoblastic leukemia and a peripheral white blood cell count of 22/mm3 who had an embolic brain infarct 2 weeks before he died. Macrophages were scarce within the lesion, suggesting that the principal phagocytic cell is hematogenous.
Casanova
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Troncoso
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JC
Price
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D000293:Adolescent; D002544:Cerebral Infarction / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology* / Q000503:physiopathology; D008264:Macrophages / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D010296:Parietal Lobe / Q000473:pathology; D013702:Temporal Lobe / Q000473:pathology