High resolution chromosome analysis of constitutional and acquired t(15;17) maps c-erbA to subband 17q11.2.
High resolution chromosome analysis was performed on bone marrow cells from four patients with acute promyelocytic leukemia and t(15;17), and in lymphocytes from two unrelated, phenotypically normal persons with an apparently identical constitutional translocation. Scrutiny of prophase-prometaphase chromosomes localized the breakpoints in all six cases to subbands 15q22.3 and 17q11.2. Molecular genetic studies have localized the oncogene c-erbA to chromosome #17 between the breakpoints of the constitutional and the acquired anomaly. The present results, therefore, map c-erbA to subband 17q11.2.
Mitelman
F
F
Manolov
G
G
Manolova
Y
Y
Billström
R
R
Heim
S
S
Kristoffersson
U
U
Mandahl
N
N
Ferro
M T
MT
San Roman
C
C
D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002901:Chromosomes, Human, 13-15 / Q000648:ultrastructure*; D002902:Chromosomes, Human, 16-18 / Q000648:ultrastructure*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009857:Oncogenes; D011519:Proto-Oncogenes; D014178:Translocation, Genetic