[Intra-arterial infusion of cisplatinum in bone and soft tissue tumors].
Cisplatin was administered by intravenous injection, intra-arterial injection, and balloon-occluded arterial infusion. The total Pt, ultrafiltrated Pt, and free Pt levels were measured. Intra-arterial injection, in which ultra-filtrated Pt level on the normal side is the same as in intravenous injection, acts to increase the ultrafiltrated Pt level on the affected side. Thus, intra-arterial injection is as effective as preoperative chemotherapy. In two-route chemotherapy, free Pt level on the affected side is extremely high, so for only local control of tumors, two-route chemotherapy is very effective.
Matsumoto
S
S
Kawaguchi
N
N
Amino
K
K
Manabe
J
J
Furuya
K
K
Isobe
Y
Y
D000818:Animals; D001859:Bone Neoplasms / Q000097:blood / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage* / Q000097:blood; D004285:Dogs; D006801:Humans; D007261:Infusions, Intra-Arterial; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D012516:Osteosarcoma / Q000097:blood / Q000188:drug therapy*; D012512:Sarcoma, Ewing / Q000097:blood / Q000188:drug therapy*; D012983:Soft Tissue Neoplasms / Q000097:blood / Q000188:drug therapy*
D002945:Cisplatin