title: Nineteen of 26 cellular oncogenes precisely localized in the human genome map to one of the 83 bands involved in primary cancer-specific rearrangements.
abstract: A total of 83 bands have been found to be specifically involved in primary structural chromosome rearrangements in human cancer. We have compared the distribution of these cancer-specific breakpoints with the chromosomal sites of the 26 cellular oncogenes currently mapped to individual bands within the human genome. Nineteen of the 26 oncogenes are localized in cancer-associated bands. This clustering of oncogene sites and cancer breakpoints is statistically highly significant (P = 0.0000012).
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002874:Chromosome Mapping; D005819:Genetic Markers; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D011519:Proto-Oncogenes
chemical_list: D005819:Genetic Markers