title: Secondary acute myeloblastic leukemia with a Ph translocation in a treated Wegener's granulomatosis.
abstract: Ph-positive acute myeloblastic leukemia (AML) developing in a treated case of Wegener's granulomatosis is reported. The patient was a 70-year-old white male who received cyclophosphamide (150 mg/day) starting in July 1978; in May 1984 the patient was diagnosed as having AML, following a diagnosis of myelodysplastic syndrome lasting 3 months. Cytogenetic study of bone marrow cells at the diagnosis of the myelodysplastic syndrome revealed a standard Ph translocation in addition to numerical chromosome changes [i.e., 45,XY, -5, -7, -8, +19, +mar/45,XY, -5, -7, -8, +19, +mar,t(9;22)(q34;q11]). The events in this case suggest a strong possibility of the Ph-positive AML being a secondary disease related to prior cyclophosphamide therapy.
authors.forename: K
authors.initials: K
authors.lastname: Ohyashiki
authors.forename: M
authors.initials: M
authors.lastname: Kocova
authors.forename: D H
authors.initials: DH
authors.lastname: Ryan
authors.forename: J M
authors.initials: JM
authors.lastname: Rowe
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
mesh_terms: D000368:Aged; D003520:Cyclophosphamide / Q000009:adverse effects*; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics*; D008297:Male; D010677:Philadelphia Chromosome
chemical_list: D003520:Cyclophosphamide