[Effect of retabolyl and oxymetacyl on protein metabolism in experimental burns in immature rats].
Impairments of protein metabolism, expressed as predominance of catabolism over anabolism and hypoproteinemia, were observed in one month old rats with experimental burns of the IIIA-IIIB degree, when 20-25% of a body surface was impaired. After administration of steroid drugs (retabolyl at a dose of 1 mg/100 g of body mass or oxymetacyl--4-methyl-5-oxyuracil---at a dose of 5 mg/100 g of body mass) content of protein and urea normalized in blood serum, activity of cathepsin D decreased in tissues, the rate of 35S-methionine incorporation into tissue proteins increased. The pyrimidine derivative oxymetacyl exhibited higher effect on protein metabolism in burns of preadolescent rats as compared with retabolyl.
Davletov
E G
EG
Saliakhova
R M
RM
Kamilov
F Kh
FKh
D000375:Aging; D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002056:Burns / Q000378:metabolism*; D002402:Cathepsin D / Q000378:metabolism; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077603:Nandrolone Decanoate; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology; D014508:Urea / Q000097:blood
D045930:Anabolic Agents; D001798:Blood Proteins; D011506:Proteins; D014498:Uracil; D009277:Nandrolone; C003029:oxymethacil; D014508:Urea; D002402:Cathepsin D; D000077603:Nandrolone Decanoate
Vliianie retabolila i oksimetatsila na belkovyĭ obmen pri éksperimental'noĭ ozhogovoĭ bolezni u nepolovozrelykh krys.