Effects of a low-fat, low-cholesterol diet on serum lipids, platelet aggregation and thromboxane formation.
The purpose of this study was to test the effects of a low-fat, low-cholesterol diet on serum lipids, platelet aggregation, thromboxane formation and blood pressure. Fifteen hyperlipidemic males with normal blood pressure were treated for 2 weeks. Resting supine blood pressure, total serum cholesterol, HDL-cholesterol, the ratio of total cholesterol/HDL-cholesterol and triglycerides all were significantly reduced. The maximum aggregation and velocity of aggregation for isolated platelets stimulated with either ADP or collagen was significantly reduced. Thromboxane formation during 5 min of platelet aggregation with collagen or ADP was also significantly reduced. These results have important implications for hypertension and atherosclerotic cardiovascular disease.
Barnard
R J
RJ
Hall
J A
JA
Chaudhari
A
A
Miller
J E
JE
Kirschenbaum
M A
MA
D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000178:diet therapy / Q000503:physiopathology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D013931:Thromboxanes / Q000096:biosynthesis*; D014280:Triglycerides / Q000097:blood
D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D004041:Dietary Fats; D008055:Lipids; D013931:Thromboxanes; D014280:Triglycerides; D002784:Cholesterol