Effect of chronic antidepressant treatment on noradrenergic modulation of [3H]dopamine release from rat nucleus accumbens and striatal slices.
Unlike desipramine, a potent blocker of noradrenaline uptake, the antidepressant drugs, mianserin and citalopram did not, after chronic administration (28 days), attenuate the clonidine-induced inhibition of [3H]dopamine (DA) release from rat nucleus accumbens slices. Mianserin, like desipramine, failed to alter the isoproterenol-induced enhancement of [3H]DA release from rat nucleus accumbens and striatal slices. These findings suggest that antidepressant action does not necessarily involve desensitization of central alpha 2- or beta-adrenoceptors which influence neuronal transmission.
Russell
V A
VA
Nurse
B
B
Lamm
M C
MC
Taljaard
J J
JJ
D000320:Adrenergic Fibers / Q000187:drug effects; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D015283:Citalopram; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D009638:Norepinephrine / Q000502:physiology*; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D011437:Propylamines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000187:drug effects*
D000928:Antidepressive Agents; D011437:Propylamines; D015283:Citalopram; D008803:Mianserin; D004298:Dopamine; D009638:Norepinephrine