[Noncompartment (model-independent) pharmacokinetic analysis. 1. The method of statistical moments in evaluating the pharmacokinetic characteristics of cefotiam following its intravenous administration].
The pharmacokinetic analysis was enriched, during the last several years, with the method of statistical moment (MSM)--an alternative for the classical compartment approach, presumed as model-non-dependent. The advantages of MSM presented are: elimination the necessity of constructing a model in advance and as a result--elaboration of complicated computer programmes. The possibilities of MSM in a comparative aspect with the traditional compartment pharmacokinetic analysis are presented in the present paper, making use of the data about cephalosporin antibiotic cefothiam after intravenous administration to patients after cholecystectomy. The values of the pharmacokinetic parameters studied, evaluated via both methods, did not statistically differ, suggesting the possibility of using MSM method as an alternative method for rapid evaluation of the pharmacokinetic parameters necessary for the elaboration of dose regimes.
Terzinvanov
D
D
D001825:Body Fluid Compartments; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D015310:Cefotiam; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008722:Methods; D008954:Models, Biological; D013223:Statistics as Topic
D015310:Cefotiam; D002439:Cefotaxime
Nekompartmenten (modelnezavisim) farmakokinetichen analiz. 1. Metod na statisticheskie momenti pri otsenka na farmakokinetichnite kharakteristiki na tsefotiam sled intravenozno vŭzezhdane.