Cardioselective antimuscarinic action of a dopamine receptor agonist, N,N-dipropyl-2-aminotetralin (TL-68).
The antimuscarinic action of N,N-dipropyl-2-amino-tetralin (TL-68) was evaluated using guinea-pig isolated electrically paced left atria, spontaneously beating atria and ileal longitudinal muscle. TL-68 competitively antagonized the responses to carbachol but was less potent than atropine in these preparations. TL-68 exhibits higher affinity towards cardiac muscarinic receptors than ileal receptors and, therefore, possesses cardioselective antimuscarinic properties. TL-68 did not show any selectivity for muscarinic receptors mediating negative inotropic and chronotropic effects.
Sahin
I
I
Hacettepe University, Faculty of Medicine, Department of Pharmacology, Ankara, Turkey.
Ilhan
M
M
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002217:Carbachol / Q000037:antagonists & inhibitors; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009281:Naphthalenes / Q000494:pharmacology*; D010276:Parasympatholytics; D011976:Receptors, Muscarinic / Q000187:drug effects; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D009281:Naphthalenes; D010276:Parasympatholytics; D011976:Receptors, Muscarinic; D013764:Tetrahydronaphthalenes; C016891:N,N-dipropyl-2-aminotetralin; D001285:Atropine; D002217:Carbachol