title: Imipenem in the treatment of severe bacterial infections in seriously ill patients.
abstract: A multicentre, non-comparative study was performed to evaluate the clinical efficacy and safety of imipenem/cilastatin given iv to 53 seriously ill patients with severe bacterial infections, including 16 episodes of UTI, 12 pleuropulmonary, eight intra-abdominal, seven osteoarticular, and two soft tissue infections, three episodes of catheter related sepsis, two primary bacteraemias, one case of endocarditis, one of endophthalmitis, and one of disseminated gonococcal infection. Twenty-five patients were bacteraemic. The overall rate of clinical response was 94% of treated episodes; three cases failed to respond. Adverse reactions were mild and comparable with those reported with other beta-lactams. No patient had clinical superinfection; colonization occurred in seven patients. Imipenem is effective and safe as a single drug therapy for a wide range of infections in seriously ill patients.
authors.forename: J
authors.initials: J
authors.lastname: Garau
authors.forename: R
authors.initials: R
authors.lastname: Martín
authors.forename: E
authors.initials: E
authors.lastname: Bouza
authors.forename: J
authors.initials: J
authors.lastname: Romero
authors.forename: J A
authors.initials: JA
authors.lastname: García Rodríguez
authors.forename: E
authors.initials: E
authors.lastname: Perea
authors.forename: F
authors.initials: F
authors.lastname: Martínez Luengas
authors.forename: M
authors.initials: M
authors.lastname: Gobernado
authors.forename: R
authors.initials: R
authors.lastname: Montero
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015378:Imipenem; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000188:drug therapy; D013845:Thienamycins / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D013845:Thienamycins; D015378:Imipenem