title: Cytogenetic analysis of a gossypol-induced murine myxosarcoma.
abstract: Cytogenetic analysis of gossypol acetate-induced murine myxosarcoma demonstrated a stemline of 78 chromosomes and the presence of three marker (M) chromosomes produced by robertsonian translocation. Tumor cells at passage 1 that contain chromosomes M1 and M2 were nontumorigenic, whereas cells at passage 3 were tumorigenic in syngeneic mice and showed M1, M2, and M3. The presence of M3 has been implicated to be responsible for the tumorigenic phenotype.
authors.forename: M K
authors.initials: MK
authors.lastname: Dhaliwal
authors.forename: J O
authors.initials: JO
authors.lastname: Norman
authors.forename: S
authors.initials: S
authors.lastname: Pathak
authors.forename: D L
authors.initials: DL
authors.lastname: Busbee
mesh_terms: D000818:Animals; D002875:Chromosomes; D005260:Female; D006072:Gossypol; D007621:Karyotyping; D008297:Male; D051379:Mice; D009236:Myxosarcoma / Q000139:chemically induced / Q000235:genetics*; D012509:Sarcoma / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D006072:Gossypol