[Homotopic transplantation of embryonic neocortical tissue into the brain of adult rats after its damage].
Structural characteristics (survival, growth, connections) have been studied in the transplant of the cerebral cortex tissue in Wistar rat embryos (18-day-old), implanted into the brain of mature rats of the same line at various time after a partial lesion of the sensomotor cortex. In 3-5 months after transplantation the light microscopy methods demonstrate that spatial interconnections of the transplant and the injured brain of the recipient depend on time interval between the cerebral lesion and transplantation of the embryonal nervous tissue. Horseradish peroxidase (HP) is ionophoretically injected into the recipient's cerebral tissue away from the place of transplantation. In the transplant retrogradely labelled HP neurons are revealed. This demonstrates efferent connections of the implanted tissue with the host's brain. Presence of the anterogradely labelled nervous terminals in the transplant tissue demonstrates existence of afferent connections of the transplant with the recipient's tissue. Possible mechanisms of survival, growth and formation of connections of the transplant in the injured brain of the mature animal are discussed.
Obukhova
G P
GP
Senatorov
V V
VV
Vartanian
G A
GA
D000818:Animals; D001921:Brain / Q000166:cytology / Q000601:surgery*; D002454:Cell Differentiation; D002540:Cerebral Cortex / Q000637:transplantation*; D004622:Embryo, Mammalian; D006085:Graft Survival; D009044:Motor Cortex / Q000293:injuries*; D009474:Neurons / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
Gomotopicheskaia transplantatsiia émbrional'noĭ tkani neokorteksa v mozg vzroslykh krys v usloviiakh ego povrezhdeniia.