title: High resolution chromosome analysis of constitutional and acquired t(15;17) maps c-erbA to subband 17q11.2.
abstract: High resolution chromosome analysis was performed on bone marrow cells from four patients with acute promyelocytic leukemia and t(15;17), and in lymphocytes from two unrelated, phenotypically normal persons with an apparently identical constitutional translocation. Scrutiny of prophase-prometaphase chromosomes localized the breakpoints in all six cases to subbands 15q22.3 and 17q11.2. Molecular genetic studies have localized the oncogene c-erbA to chromosome #17 between the breakpoints of the constitutional and the acquired anomaly. The present results, therefore, map c-erbA to subband 17q11.2.
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
authors.forename: G
authors.initials: G
authors.lastname: Manolov
authors.forename: Y
authors.initials: Y
authors.lastname: Manolova
authors.forename: R
authors.initials: R
authors.lastname: Billström
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: U
authors.initials: U
authors.lastname: Kristoffersson
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: M T
authors.initials: MT
authors.lastname: Ferro
authors.forename: C
authors.initials: C
authors.lastname: San Roman
mesh_terms: D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002901:Chromosomes, Human, 13-15 / Q000648:ultrastructure*; D002902:Chromosomes, Human, 16-18 / Q000648:ultrastructure*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009857:Oncogenes; D011519:Proto-Oncogenes; D014178:Translocation, Genetic