title: Clonidine in the treatment of Tourette's syndrome exacerbation due to haloperidol withdrawal.
abstract: A patient with long-standing Tourette's syndrome had a dramatic exacerbation of symptoms following the rapid withdrawal of haloperidol. Clonidine administration resulted in a disappearance of tics, which recurred 6 days later. The role of clonidine in blocking withdrawal-induced symptoms in patients with Tourette's syndrome treated with long-term neuroleptics is discussed from a clinical and neurobiological perspective. The implications of this case for the treatment of supersensitivity psychosis and tricyclic withdrawal states with clonidine are also discussed.
authors.forename: J E
authors.initials: JE
authors.lastname: Max
authors.forename: S A
authors.initials: SA
authors.lastname: Rasmussen
mesh_terms: D000208:Acute Disease; D000328:Adult; D003000:Clonidine / Q000627:therapeutic use*; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000209:etiology; D005879:Tourette Syndrome / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology
chemical_list: D006220:Haloperidol; D003000:Clonidine