title: [Elimination of polypeptide antibiotics (colistin and bacitracin) in the milk after intramuscular or intramammary administration].
abstract: The elimination in cow's milk of polypeptidic antibiotic residues (colistin sulfate, colistin methanesulfonate and bacitracin) was investigated following intramuscular and intramammary administrations of eight drugs marketed in France. The quantitative analysis was performed according to the microbiological method of agar diffusion. The mean elimination periods lasted between three and six milkings for injected preparations, between four and six milkings for intramammary ones. These results were used as a basis to determine the withdrawal times required on these drugs. The problem of the diffusion of the residues into milk from a quarter treated by the intramammary route, to the untreated quarters was also addressed.
authors.affiliation: Services Vétérinaires, Laboratoire National des Médicaments Vétérinaires, Fougères, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Moretain
authors.forename: J
authors.initials: J
authors.lastname: Boisseau
mesh_terms: D000818:Animals; D001414:Bacitracin / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D002417:Cattle / Q000378:metabolism*; D003091:Colistin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism*; D004350:Drug Residues / Q000378:metabolism*; D005260:Female; D007273:Injections, Intramuscular; D008321:Mammary Glands, Animal / Q000378:metabolism; D008892:Milk / Q000032:analysis*
chemical_list: D001414:Bacitracin; C004691:colistinmethanesulfonic acid; D003091:Colistin
vernacular_title: Elimination des antibiotiques polypeptidiques (colistine et bacitracine) dans le lait après administration intramusculaire ou intramammaire.