Degradation kinetics of imipenem in normal saline and in human serum.
The stability of imipenem in 0.9% sodium chloride and in human serum was measured at controlled temperatures over time. The degradation was characterized by a first-order process and was consistent with an apparent hydrolysis reaction.
Swanson
D J
DJ
DeAngelis
C
C
Smith
I L
IL
Schentag
J J
JJ
D004355:Drug Stability; D006207:Half-Life; D006801:Humans; D015378:Imipenem; D007700:Kinetics; D012965:Sodium Chloride; D013696:Temperature; D013845:Thienamycins / Q000032:analysis / Q000097:blood*
D013845:Thienamycins; D012965:Sodium Chloride; D015378:Imipenem