Hemodynamic effects at rest and during exercise of long-term sodium restriction in mild essential hypertension.
During moderate sodium restriction for 9 months in 19 men (33 years) with previously untreated mild essential hypertension (EH) sodium excretion fell from 209 to 139 mmol/24 h. Concomitantly intraarterial pressure at rest sitting fell from 145/93 to 138/88 mmHg (5%) and during 100 W exercise from 168/90 to 162/86 mmHg (4%). The fall in BP was due to reduction in cardiac output (5-11% at rest and during exercise) while peripheral vascular resistance was raised (4-10%). Thus, moderate sodium restriction was not very efficient treatment in our patients with mild EH. The main hemodynamic disturbance of established EH--an increase in vascular resistance--was not normalized after 9 months of low salt diet.
Omvik
P
P
Lund-Johansen
P
P
D000293:Adolescent; D000328:Adult; D004039:Diet, Sodium-Restricted; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000178:diet therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009318:Natriuresis; D005082:Physical Exertion; D011188:Potassium / Q000652:urine
D011188:Potassium