In vitro effect of trifluoperazine on human lymphocytes.
Trifluoperazine, a phenothiazine group of tranquilizer was studied for its chromosome damaging effect in human lymphocyte cultures. The cells were treated with 10, 15 and 20 micrograms/culture of trifluoperazine for 24, 48 and 72 hours. A high incidence of chromatid breaks and gaps was observed after 48 and 72 hours treatment. The study revealed that the drug acts mostly on the late S and G2 phase of the cell cycle.
Suryanarayana
A
A
Institute of Genetics, Osmania University, Begumpet, Hyderabad, Aandra Pradesh, India.
Rita
P
P
Reddy
P P
PP
D002842:Chromatids / Q000648:ultrastructure; D002869:Chromosome Aberrations; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects*; D013997:Time Factors; D014268:Trifluoperazine / Q000494:pharmacology*
D014268:Trifluoperazine