Rings and double minutes in a case with blastic phase of chronic myelocytic leukemia.
The patient studied was a 33-year-old female in the blastic phase of chronic myelocytic leukemia resistant to busulfan. The results of cytogenetic studies of bone marrow cells were as follows: The abnormal chromosomes were double Ph1, +19, +6, +B, ring D, double ring D, double minutes (DM) of various sizes, etc. The mean number of DM per cell was increased in 4-day culture compared with that in 1-day culture.
Uehara
M
M
Kida
M
M
Kamakura
M
M
D000328:Adult; D001752:Blast Crisis / Q000235:genetics*; D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D010677:Philadelphia Chromosome; D012303:Ring Chromosomes