[CA-50 in serum of patients with carcinoma. Clinical experiences with a new tumor marker].
Quantitative radioimmunological demonstration of carbohydrate antigen CA-50 in serum achieved a sensitivity of 62.3% for colorectal carcinoma (n = 53), of 64.7% for gastric carcinoma (n = 34), of 33.9% for lung carcinoma (n = 56), and 19.8% for lymphoproliferative diseases (n = 91). The positive results for the latter probably correspond to the immunohistological demonstration of the antigen in dendritic reticulum cells. Occasionally an increased CA-50 level in inflammatory disease presents difficulties in differential diagnosis, but it returns to normal when the inflammatory process has subsided. Methodological scatter of the CA-50 system is satisfactory, with a coefficient of variation of +/- 11%, but unsatisfactory at low values (less than or equal to 10 U/ml) and high ones (greater than or equal to 50 U/ml) with a coefficient of variation of +/- 19%. Further development with the IMRA technique may significantly reduce methodological scatter (coefficient of variation +/- 5%).
Bruhn
H D
HD
Broers
H
H
Euler
H
H
Everding
A
A
Feller
A C
AC
Hedderich
J
J
Jostarndt
L
L
Jooss
B
B
Zurborn
K H
KH
Löffler
H
H
D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis* / Q000276:immunology; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000276:immunology; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000276:immunology; D011863:Radioimmunoassay; D012004:Rectal Neoplasms / Q000175:diagnosis* / Q000276:immunology; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000276:immunology
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen
CA-50 im Serum von Karzinom-Patienten. Klinische Erfahrungen mit einem neuen Tumormarker.