title: [Right ventricular systolic and diastolic functions assessed by 81mKr scintigraphy and relation to ventricular septal ischemia].
abstract: Right ventricular (RV) systolic and diastolic functions were assessed in patients with previous anteroseptal myocardial infarction to ascertain the influence of interventricular septal ischemia on RV function. Gated right ventriculography with continuous infusion of krypton-81 m was performed in 12 normal subjects and 28 patients with infarction but without significant stenosis of the right coronary artery. Furthermore, RV contractile reserve by postextrasystolic potentiation was evaluated by gated radionuclide ventriculography with 99mTc-HSA. The patients with anteroseptal infarction were divided into two groups by the presence or absence of three hours' redistribution in the septal region on exercise thallium-201 myocardial scintigraphy. Two indices of systolic function (ejection fraction and the peak ejection rate) and three indices of diastolic function (1/3 diastolic filling rate, the peak filling rate and time to the peak filling rate) were derived from the right ventricular time-activity curve and its derivative curve. There was no difference in systolic function among normal subjects and patients with or without redistribution. However, diastolic function was impaired only in the patients without redistribution. The RV contractile reserve in the patients without redistribution was less than in those with it. Thus, RV systolic function was maintained in the patients with anteroseptal infarction, but contractile reserve deteriorated only in severe septal ischemia. Similarly, diastolic function was maintained in mild septal ischemia, but impaired in severe septal ischemia. We concluded that RV systolic and diastolic functions are closely related to interventricular septal ischemia.
authors.affiliation: Second Department of Medicine, Kyoto Prefectural University of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Sugihara
authors.forename: H
authors.initials: H
authors.lastname: Adachi
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
authors.forename: S
authors.initials: S
authors.lastname: Inagaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: T
authors.initials: T
authors.lastname: Ebizawa
authors.forename: K
authors.initials: K
authors.lastname: Furukawa
authors.forename: J
authors.initials: J
authors.lastname: Asayama
authors.forename: H
authors.initials: H
authors.lastname: Katsume
authors.forename: H
authors.initials: H
authors.lastname: Ijichi
mesh_terms: D003971:Diastole; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D007727:Krypton Radioisotopes; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D013599:Systole; D013667:Technetium
chemical_list: D007727:Krypton Radioisotopes; D013667:Technetium