[Effect and toxicity of entrapped polysiloxane 5-Fu polycondensate].
Entrapped 5-Fu polysiloxane polycondensate (DMS-Fu) and equivalent doses of 5-Fu were tested on S-180 mice. At the dose of 100 mg/kg, the inhibition potency of these two compounds on tumor was similar, but the inhibition on the body weight was more marked in 5-Fu treated mice. At the dose of 250 mg/kg, all mice treated with 5-Fu died of toxicity but the mice treated with DMS-Fu survived and showed no obvious toxic effect. At the dose of 150-200 mg/kg, the peripheral white blood cells and the bone marrow nucleated cells of 5-Fu treated mice were seriously reduced, which lasted for several days before recovery. In the DMS-Fu group, the inhibition was mild.
Fu
N W
NW
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
Zhang
L S
LS
Quan
L P
LP
Guo
R
R
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000473:pathology; D002452:Cell Count / Q000187:drug effects; D003692:Delayed-Action Preparations; D005260:Female; D005472:Fluorouracil / Q000633:toxicity*; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000473:pathology; D012828:Silicones / Q000633:toxicity*; D012833:Siloxanes / Q000633:toxicity*
C056390:5-fluorouracil-polysiloxane condensate; D003692:Delayed-Action Preparations; D012828:Silicones; D012833:Siloxanes; D005472:Fluorouracil