title: [State of the immune system of the fetus and newborn infant in late pregnancy toxemias].
abstract: Histologic and morphometric studies were performed on lymphoid organs of fetuses and neonates from mothers with late gestosis. The thymuses were found to be mature with minimal signs of activation if the mothers had edema, first-degree nephropathy, or second- to third-degree nephropathy of less than 2 weeks in duration. In cases of longer-lasting nephropathy of degree 2 or 3, the thymuses were often retarded in their development, had considerable structural abnormalities and reduced weight, decreased lymphocytes numbers in the cortex and medulla, contracted lobes, and elevated numbers of Hassall's bodies. Prolonged severe toxemia led, in some instances, to diminished thymic activity, as documented by calcification of these bodies. A feature of the fetal thymic response to maternal toxemia was the absence of accidental transformation with its typical phasic changes. In the peripheral lymphoid organs, stimulation of the humoral arm of immunity was clearly observed.
authors.forename: S M
authors.initials: SM
authors.lastname: Osipov
authors.forename: A V
authors.initials: AV
authors.lastname: Tolokol'nikov
mesh_terms: D005260:Female; D005333:Fetus / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn / Q000276:immunology*; D011225:Pre-Eclampsia / Q000276:immunology* / Q000473:pathology; D011247:Pregnancy; D013154:Spleen / Q000276:immunology / Q000473:pathology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology
vernacular_title: Sostoianie immunnoĭ sistemy plodov i novorozhdennykh pri pozdnikh toksikozakh beremennykh.