title: Plasma albumin concentrations and intestinal permeability in Bangladeshi children infected with Ascaris lumbricoides.
abstract: Plasma albumin concentration and intestinal permeability have been investigated in Bangladeshi children before and 9-14 d after successful treatment for ascariasis. Children infected with A. lumbricoides had lower plasma albumin concentrations than counterparts not harbouring this worm and values increased with successful treatment. Intestinal permeability tests indicated that the children had impaired gastrointestinal function and some loss of mucosal integrity; these factors had not improved 9-14 d after A. lumbricoides expulsion. The lowered nitrogen nutritional status implied by the reduced plasma albumin values in infected children, and the improvement following treatment, are in keeping with previous reports that A. lumbricoides impairs protein digestion or absorption. This may be the basis of the better growth rates of dewormed children in this area.
authors.affiliation: MRC Dunn Nutrition Laboratory, Cambridge, UK.
authors.forename: C A
authors.initials: CA
authors.lastname: Northrop
authors.forename: P G
authors.initials: PG
authors.lastname: Lunn
authors.forename: M
authors.initials: M
authors.lastname: Wainwright
authors.forename: J
authors.initials: J
authors.lastname: Evans
mesh_terms: D000871:Anthelmintics / Q000627:therapeutic use; D001196:Ascariasis / Q000188:drug therapy / Q000378:metabolism* / Q000469:parasitology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000469:parasitology; D008297:Male; D010539:Permeability; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D000871:Anthelmintics; D012709:Serum Albumin