title: Evidence for a cellular gene with potential oncogenic activity in plants.
abstract: During tumor inception in crown gall disease, a portion of the tumor-inducing (Ti) plasmid, the transferred DNA (T-DNA), is integrated into the genome of the plant cell. Autonomous growth of the transformants requires expression of genes in the tmr and tms regions of the T-DNA, which code for enzymes concerned with biosynthesis of the plant growth hormones cytokinin and auxin, respectively. We show that a mutation of the Habituated leaf gene, Hl, of tobacco can compensate for a defective tmr locus in expression of the tumor phenotype. This provides evidence that a specific host-cell gene has an oncogenic function similar to tmr in the T-DNA.
authors.forename: C E
authors.initials: CE
authors.lastname: Hansen
authors.forename: F
authors.initials: F
authors.lastname: Meins
mesh_terms: D002453:Cell Cycle; D002460:Cell Line; D003583:Cytokinins / Q000502:physiology; D004273:DNA, Neoplasm / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010941:Plant Tumors; D010947:Plants, Toxic; D010957:Plasmids; D011519:Proto-Oncogenes; D014026:Nicotiana / Q000235:genetics*
chemical_list: D003583:Cytokinins; D004273:DNA, Neoplasm