Genetic analysis of the proximal portion of the mouse t complex: evidence for a second inversion within t haplotypes.
Genomic sequences derived from the mouse t complex by a microdissection cloning technique have been used as tools to obtain high resolution genetic maps of the wild-type and t haplotype forms of the most proximal portion of chromosome 17. Genetic mapping was performed through a recombinant inbred strain analysis and an analysis of partial t haplotypes. The accumulated data demonstrate the existence of a large inversion of genetic material, encompassing the loci of T and qk, within the proximal portion of t haplotypes. This newly described proximal inversion and the previously described distal inversion provide an explanation for the suppression of recombination observed along the length of t haplotype DNA in heterozygous mice.
Herrmann
B
B
Bućan
M
M
Mains
P E
PE
Frischauf
A M
AM
Silver
L M
LM
Lehrach
H
H
D000818:Animals; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D005819:Genetic Markers; D006579:Heterozygote; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009154:Mutation; D011995:Recombination, Genetic
D005819:Genetic Markers