[Behavior and biological action of large amounts of 239Pu following intramuscular administration in rats undergoing long-term therapy with Zn- and Ca-DTPA].
The authors submit the results of the studies of the influence of large amounts of 239Pu, administered to rats via stab wounds, and subsequent treatment there of with clinical doses of Zn- and Ca-DTPA for two months. It is shown that the absorbed doses considerably decrease and the average life of treated rats increases; the incidence of malignant tumors does not change after the treatment with Ca-DTPA.
Siniakov
E G
EG
Bazhin
A G
AG
Liubchanskiĭ
E R
ER
Nifatov
A P
AP
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control*; D009566:Nitrates; D012516:Osteosarcoma / Q000209:etiology / Q000517:prevention & control*; D004369:Pentetic Acid / Q000627:therapeutic use*; D011005:Plutonium / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D009566:Nitrates; C015459:plutonium nitrate; D011005:Plutonium; D004369:Pentetic Acid
Povedenie i biologicheskoe deĭstvie bol'shikh kolichestv 239Pu posle vnutrimyshechnogo vvedeniia u krys v usloviiakh dlitel'noĭ terapii Zn- i Ca-DTPA.