[Effectiveness of peptoran (ranitidine) in peptic ulcer according to the results of a study on intracavitary protein hydrolysis in the upper digestive tract].
The efficacy of peptoran use was studied in 35 patients with peptic ulcer localized in the duodenal bulb on the basis of the results of clinical and endoscopic investigations. Proteolytic activity in the esophagus, stomach and duodenum, and peptoran influence on it were studied. Clinical signs of exacerbation disappeared 5 days after the drug administration. According to the results of repeated endoscopy ulcer cicatrization was observed in 31 of 35 patients after 2-week drug administration. A significant decrease in intragastric proteolysis was established, the number of patients with intraesophageal proteolytic activity was decreased 3-fold; intraduodenal proteolytic activity under the influence of peptoran was unchanged. Peptoran produced no effect on the expression of duodenogastric and gastroesophageal refluxes.
Masevich
Ts G
TsG
Gorshkov
V A
VA
Nasonova
N V
NV
Vaĭnores
S A
SA
Emskaia
K M
KM
D004341:Drug Evaluation; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D004386:Duodenum / Q000378:metabolism*; D004947:Esophagus / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D011506:Proteins / Q000378:metabolism*; D011899:Ranitidine / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
D011506:Proteins; D011899:Ranitidine
Effektivnost' peptorana (ranitidina) pri iazvennoĭ bolezni po rezul'tatam issledovaniia vnutripolostnogo gidroliza belka v verkhnikh otdelakh pishchevaritel'nogo trakta.