The pathobiology of Dupuytren's contracture: effects of prostaglandins on myofibroblasts.
The in vitro response of myofibroblasts to prostaglandins F2alpha (a vasoconstrictor) and E2 (a vasodilator) were evaluated in specimens obtained from the Dupuytren's nodules of 12 patients. Fibroblasts from four control samples of palmar fascia were similarly tested. This study demonstrated the ability of prostaglandin F2alpha to induce significant contraction of myofibroblasts. Prostaglandin E2 was noted to cause significant relaxation of myofibroblasts. The contractile/relaxation responses of control fibroblasts to these prostaglandins were minimal.
Hurst
L C
LC
Badalamente
M A
MA
Makowski
J
J
D002478:Cells, Cultured; D015237:Dinoprost; D015232:Dinoprostone; D004387:Dupuytren Contracture / Q000473:pathology / Q000503:physiopathology*; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009132:Muscles / Q000187:drug effects* / Q000648:ultrastructure; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D012828:Silicones
D011458:Prostaglandins E; D011460:Prostaglandins F; D012828:Silicones; D015237:Dinoprost; D015232:Dinoprostone