Effects of anti-tuberculosis drugs on the production of prostaglandin E2 and on mononuclear leucocyte transformation.
The effects of the anti-tuberculosis (TB) drugs isoniazid, rifampicin, streptomycin, pyrazinamide and ethambutol on the synthesis of prostaglandin E2 (PGE2) by polymorphonuclear leucocytes were investigated. Only rifampicin at a concentration of 100 micrograms/ml caused statistically significant stimulation of PGE2 production whereas the other compounds had no effect. Immunomodulatory properties of the compounds individually and in combination were investigated using phytohaemagglutinin-stimulated mononuclear leucocyte transformations. Rifampicin caused dose-dependent inhibition of blastogenesis and combinations containing this agent also had an inhibitory effect. The prostaglandin synthesis inhibitor indomethacin caused stimulation of phytohaemagglutinin responsiveness and this effect was not influenced by the presence of the anti-TB drugs.
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D000995:Antitubercular Agents / Q000494:pharmacology*; D015232:Dinoprostone; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D009000:Monocytes / Q000187:drug effects; D011458:Prostaglandins E / Q000096:biosynthesis*
D000995:Antitubercular Agents; D011458:Prostaglandins E; D015232:Dinoprostone; D007213:Indomethacin