Acute myelomonocytic leukemia (M4) with eosinophilia: problems concerning chromosome 16 abnormality.
A case of acute myelomonocytic leukemia is reported which was hematologically classified as M4 (FAB), because the patient had a high count of immature eosinophils with typical histochemical features in the bone marrow. An abnormal chromosome #16 was found besides a trisomy 22 or a monosomy 18 in part of the cultured bone marrow cells and unstimulated blood cells but not in directly prepared bone marrow. The structural aberration of chromosomes #16, which was demonstrated best by CBG-banding, was more likely due to a partial deletion of the long arm than to an inversion. The difficulties involved in correct cytogenetic diagnosis of such cases are discussed.
Harth
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Pees
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Zankl
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D001853:Bone Marrow / Q000473:pathology; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002885:Chromosomes, Human, Pair 16; D004802:Eosinophilia / Q000150:complications / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics*; D008214:Lymphocytes / Q000166:cytology; D008875:Middle Aged