[Clinical value of urinary kallikrein determination in obstetrics].
Whether to determine the urinary kallikrein (UKK) level in the second trimester of pregnancy is valuable or not for the prediction of gestosis, especially of hypertension in the third trimester of pregnancy, was studied on 700 cases of pregnant women including 50 cases of gestosis. The main results obtained were as follows. Sixty cases of 610 non-gestotic women were low in UKK, and 17 of these cases later resulted in gestosis or preterm delivery. When a patient with mild gestosis and/or hypertension was admitted, the UKK level was elevated significantly in general by bed rest and a low-salt diet. The UKK level was more significantly lowered in threatened preterm delivery than in normal pregnant women (p less than 0.001). A close positive correlation was seen between UKK levels and prostaglandin E2 in urine in pregnant women (n = 30, r = 0.528). A relatively close correlation was seen between UKK levels and roll-over test results (n = 30). From these results, the authors reached the conclusion that to determine UKK in the second trimester of pregnancy is quite valuable in predicting not only gestosis and/or hypertension in the third trimester of pregnancy but also preterm delivery.
Saitoh
M
M
Hada
Y
Y
Munakata
S
S
Sada
I
I
Hiraoka
T
T
Nakamura
Y
Y
Nomura
Y
Y
Shinagawa
S
S
D000328:Adult; D015232:Dinoprostone; D005260:Female; D006801:Humans; D006973:Hypertension / Q000652:urine; D007610:Kallikreins / Q000652:urine*; D011225:Pre-Eclampsia / Q000652:urine*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000652:urine; D011458:Prostaglandins E / Q000652:urine
D011458:Prostaglandins E; D007610:Kallikreins; D015232:Dinoprostone