title: Nesting: hierarchies of allosteric interactions.
abstract: A generalization of the allosteric model is presented that incorporates a hierarchy of conformational equilibria. Such a formulation draws upon structural organization already seen in many large macromolecular systems. The functional binding properties of the macromolecule reflect conformational equilibria at each structural level. Appropriate "nested" models are used to interpret structural features and functional aspects of two hemocyanin systems with a large number (12 and 24) of binding sites.
authors.forename: C H
authors.initials: CH
authors.lastname: Robert
authors.forename: H
authors.initials: H
authors.lastname: Decker
authors.forename: B
authors.initials: B
authors.lastname: Richey
authors.forename: S J
authors.initials: SJ
authors.lastname: Gill
authors.forename: J
authors.initials: J
authors.lastname: Wyman
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D001704:Biopolymers; D002248:Carbon Monoxide; D006433:Hemocyanins / Q000378:metabolism*; D046911:Macromolecular Substances; D008433:Mathematics; D008954:Models, Biological; D008968:Molecular Conformation; D008121:Nephropidae; D010100:Oxygen / Q000378:metabolism*; D011485:Protein Binding; D013112:Spiders
chemical_list: D001704:Biopolymers; D046911:Macromolecular Substances; D002248:Carbon Monoxide; D006433:Hemocyanins; D010100:Oxygen