[Functional disorders of the hypothalamo-pituitary-thyroid axis in epilepsy].
Changes of the hormonal functions of the axis hypothalamus-hypophysis-thyroid were assessed in epileptics prior to the beginning of the anticonvulsant therapy (50 cases), during short-lasting treatment (12 months) and during long-lasting treatment (54 cases treated during a mean period of 15.3 years). The serum levels were determined of thyreotropin (TSH), total T4, total T3, total cholesterol, and thyroxin-binding globulin capacity. The test of TRH stimulation was used for the determination of the hypothalamo-hypophyseal system function. It was found that epilepsy may impair the function of the axis hypothalamus-hypophysis-thyroid probably at the hypothalamic level. Anticonvulsants (diphenylhydantoin, phenobarbital, carbamazepine) may cause hormonal disturbances producing both tertiary and primary hypothyroidism, and in patients treated many years the response of the TSH was more evidently impaired than in the cases treated for a short time.
Magiera
J
J
II Kliniki Neurologicznej S1. AM w Zabrzu.
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology*; D007037:Hypothyroidism / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000187:drug effects / Q000503:physiopathology*; D013972:Thyrotropin / Q000037:antagonists & inhibitors / Q000172:deficiency*
D000927:Anticonvulsants; D013972:Thyrotropin
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