Role of heterochromatin during preferential 9q;22q translocation in chronic myelogenous leukemia.
The secondary constriction region (h) of human chromosome 9 was evaluated in 55 chronic myelogenous leukemia (CML) patients with respect to its size and position. Each case was examined by C-banding and distamycin A-4,6-diamidino-2-phenylindole techniques for the expression of the h regions. When one h region of chromosome 9 was larger, it was more frequently involved in the reciprocal translocation with chromosome 22. In addition, there was a higher incidence of pericentric inversions in the h regions in the translocated chromosome 9 when compared with normal homologues. The role of the constitutive heterochromatin of chromosome 9 as a possible influencing factor during 9q;22q translocation in CML is suggested.
Verma
R S
RS
Rodriguez
J
J
Babu
A
A
Chemitiganti
S
S
Coleman
M
M
Silver
R T
RT
Dosik
H
H
D002871:Chromosome Banding; D002899:Chromosomes, Human, Pair 9; D006570:Heterochromatin / Q000502:physiology*; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D014178:Translocation, Genetic
D006570:Heterochromatin