[Concentrations of cefmenoxime in human bone marrow blood and osseous tissue].
One gram of cefmenoxime (CMX) was administered to each of 10 patients by a one shot intravenous injection at the beginning of surgery. At 30, 60, 90, 120 minutes after the administration, concentrations of CMX in venous blood, bone marrow blood and bone tissue were assayed by the agar-well method. CMX was smoothly transmigrated after the injection from venous blood to bone marrow blood and bone tissue, and effective concentrations higher than MIC80 values were maintained for several hours. CMX, therefore, appears to be a useful drug for the prophylaxis and the treatment of postoperative infections.
Kurata
Y
Y
Kushimoto
H
H
Hoshi
Y
Y
Yutani
Y
Y
Tajima
K
K
Yanai
N
N
Sumita
M
M
Horisawa
Y
Y
D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D015281:Cefmenoxime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011292:Premedication; D013514:Surgical Procedures, Operative; D013530:Surgical Wound Infection / Q000517:prevention & control
D015281:Cefmenoxime; D002439:Cefotaxime