title: Some effects of piperazine citrate on skeletal muscle and central nervous system.
abstract: In the frog rectus abdominis and rat phrenic nerve-diaphragm preparations, piperazine citrate was shown to have some neuromuscular blocking activity. In the rat, d-tubocurarine was 500 times more potent than piperazine. This neuromuscular blocking effect of piperazine may be responsible for the hypotonia it sometimes induces in man. High doses of piperazine increased, in mice, the sleeping time due to pentobarbitone, but decreased the threshold for convulsion due to leptazol and strychnine, thus explaining piperazine-induced somnolence and worsening of epileptic attacks in man.
authors.affiliation: Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu.
authors.forename: G
authors.initials: G
authors.lastname: Onuaguluchi
authors.forename: W C
authors.initials: WC
authors.lastname: Mezue
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D001001:Anura; D001921:Brain / Q000187:drug effects*; D003292:Convulsants; D004347:Drug Interactions; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009132:Muscles / Q000187:drug effects*; D009431:Neural Conduction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects
chemical_list: D000969:Antinematodal Agents; D003292:Convulsants; D010879:Piperazines; C006589:piperazine citrate