[Role of bacterial lipopolysaccharide pyrogenal in the development of congenital defects in embryos of second-generation Syrian hamsters].
Effect of bacterial lipopolysaccharide (pyrogenal) on development of golden hamster embryos of the second generation has been studied. The female hamsters are given pyrogenal once--intramuscularly 500-625 mpd/kg on the 9th-14th day of pregnancy. The embryos of the second generation are examined on the 15th day of pregnancy. The external observation is performed, body mass is estimated, state of the internal organs is studied. Death and congenital defects of development are essential among the embryos after implantation. Among alive embryos the congenital defects are noticed in 30% of cases, among the dead ones--in 63%. In the control group the congenital defects are found in 1.7% of cases.
Bandazhevskiĭ
Iu I
IuI
D000014:Abnormalities, Drug-Induced; D000818:Animals; D006224:Cricetinae; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D008070:Lipopolysaccharides / Q000633:toxicity*; D008647:Mesocricetus; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D008070:Lipopolysaccharides; C009136:pyrogenal
Rol' bakterial'nogo lipopolisakharida pirogenala v vozniknovenii vrozhdennykh porokov razvitiia u zarodysheĭ siriĭskikh khomiachkov vtorogo pokoleniia.