[Radiation protection of mice with hypoxic gas mixtures after administration of anti-hypoxic agents].
It is shown that such substances as gutimine, antizol and mexamine increases the resistance of animals to short-term breathing of gas mixtures containing 6 and 5% oxygen. Even if some of them decrease the degree of radioprotective effect of hypoxia, they afford the possibility to safe use of breathing mixtures with lower oxygen content than endured by intact animals, with the resulting increase in radioprotection. Thus the antihypoxic substances can be tested during hypoxiradiotherapy of human tumors.
Waĭnson
A A
AA
Uriupov
O Iu
OIu
D008735:5-Methoxytryptamine / Q000494:pharmacology; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D006164:Guanylthiourea / Q000494:pharmacology; D008297:Male; D051379:Mice; D009292:Narcotic Antagonists / Q000494:pharmacology; D010100:Oxygen / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents; D013830:Thiadiazoles
D009292:Narcotic Antagonists; D011837:Radiation-Protective Agents; D013830:Thiadiazoles; C044365:amtizol; D008735:5-Methoxytryptamine; D006164:Guanylthiourea; D010100:Oxygen
Radiozashchita mysheĭ gipoksicheskimi gazovymi smesiami na fone vvedeniia antigipoksantov.