title: An enhancer responsible for activating transcription at the midblastula transition in Xenopus development.
abstract: Transcripts from the Xenopus gene GS17 are absent from oocytes and first appear at the midblastula transition (MBT), about 8 hr after fertilization. Injection experiments with deletions of the GS17 gene and GS17-beta-globin hybrid genes show that a relatively short sequence of 74 base pairs is sufficient to activate, in cis, transcription at the MBT. This 74-base sequence is located about 700 bases upstream of the GS17 promoter and has the properties of an enhancer element.
authors.forename: P A
authors.initials: PA
authors.lastname: Krieg
authors.forename: D A
authors.initials: DA
authors.lastname: Melton
mesh_terms: D000818:Animals; D001483:Base Sequence; D001755:Blastocyst / Q000378:metabolism*; D004625:Embryo, Nonmammalian / Q000378:metabolism; D004742:Enhancer Elements, Genetic; D005260:Female; D005796:Genes; D005809:Genes, Regulator; D010957:Plasmids; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic; D014982:Xenopus laevis
chemical_list: D012333:RNA, Messenger