Effect of nicotine chewing gum on salivary secretion.
The effect of nicotine, placebo for nicotine or menthol-tasting chewing gums on salivation was studied in 25 healthy volunteers. The chewing of a commercial nicotine containing (2 mg) chewing gum (Nicorette) did not give a larger rate of salivation than did the chewing of a placebo chewing gum. For both types of chewing gums the rate of salivation was highest during the initial 5 min and it decreased thereafter. Menthol-tasting chewing gum gave a significantly higher amount of stimulated saliva. It is concluded that the addition of nicotine to a chewing gum does not provide an additional stimulus for salivation.
Dunér-Engström
M
M
Larsson
O
O
Lundberg
J
J
Fredholm
B B
BB
D000328:Adult; D002638:Chewing Gum; D005260:Female; D006801:Humans; D008297:Male; D008610:Menthol / Q000494:pharmacology; D009538:Nicotine / Q000494:pharmacology*; D010919:Placebos; D012463:Saliva / Q000187:drug effects / Q000378:metabolism*; D012472:Salivation / Q000187:drug effects; D013997:Time Factors
D002638:Chewing Gum; D010919:Placebos; D008610:Menthol; D009538:Nicotine