title: RCH-ACV: a lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8.
abstract: A cell line (RCH-ACV) was established from a bone marrow sample of a child with acute lymphoblastic leukemia (ALL). The cell line lacked Epstein-Barr virus nuclear antigen and exhibited a recently described nonrandom chromosome translocation, 1;19, thought to be associated with pre-B-ALL and poor prognosis. Banding studies confirm that the breakpoint of chromosome #19 occurs at p13.3. Cell surface marker analysis using a panel of monoclonal antibodies revealed markers consistent with common ALL phenotype. Although the cells did not show cytoplasmic immunoglobulin, studies of the immunoglobulin gene rearrangement confirmed the pre-B phenotype. This cell line could be of great value to studies of the role of the specific translocation 1;19 in the etiology of pre-B-ALL.
authors.forename: I
authors.initials: I
authors.lastname: Jack
authors.forename: R
authors.initials: R
authors.lastname: Seshadri
authors.forename: M
authors.initials: M
authors.lastname: Garson
authors.forename: P
authors.initials: P
authors.lastname: Michael
authors.forename: D
authors.initials: D
authors.lastname: Callen
authors.forename: H
authors.initials: H
authors.lastname: Zola
authors.forename: A
authors.initials: A
authors.lastname: Morley
mesh_terms: D002460:Cell Line; D002648:Child; D002900:Chromosomes, Human, 1-3; D002903:Chromosomes, Human, 19-20; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D014178:Translocation, Genetic; D014314:Trisomy
chemical_list: D007136:Immunoglobulins