Interaction between prostaglandin E2 and noradrenalin on collagen synthesis in human cervical tissue during pregnancy.
The effects of prostaglandin E2 (PGE2) and noradrenalin (NA) on the incorporation of [3H]proline in cervical tissue of pregnant women were investigated. NA inhibited the incorporation in early as well as in term pregnancy. PGE2 counteracted the NA-effect in the former group of patients but did not affect the influence of NA at term. The results demonstrate an interaction between PGE2 and NA and point to a hitherto unknown effect of NA in the regulation of cervical connective tissue metabolism.
Norström
A
A
Tjugum
J
J
Wilhelmsson
L
L
Hamberger
L
L
D002584:Cervix Uteri / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis*; D015232:Dinoprostone; D005260:Female; D006801:Humans; D009638:Norepinephrine / Q000494:pharmacology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011263:Pregnancy Trimester, Third; D011458:Prostaglandins E / Q000494:pharmacology*
D011458:Prostaglandins E; D003094:Collagen; D015232:Dinoprostone; D009638:Norepinephrine