Pancreatic carcinogenesis: effect of secretin in the hamster- nitrosamine model.
The effect of exogenous secretin on pancreatic carcinogenesis in WO strain hamsters has been examined in the nitrosamine-ductular adenocarcinoma model. Secretin, 20 clinical U/kg, stimulated a maximal secretory response of pancreatic juice and bicarbonate when given iv. The same dose given sc for 6 weeks had no significant effect on pancreatic wet weight and DNA or RNA contents. However, when given to animals receiving N-nitrosobis(2-oxopropyl)amine [(BOP) CAS: 60599-38-4] (5 mg/kg), it reduced the latency and increased the induction rate of tumor development when compared with the carcinogen given alone to animals (secretin + BOP, 15 of 17 animals with tumors; BOP alone, 4 of 13 with tumors at 15 wk; P less than .002). These effects are consistent with secretin acting as a cocarcinogen in this model of pancreatic carcinogenesis.
Howatson
A G
AG
Carter
D C
DC
D000230:Adenocarcinoma / Q000139:chemically induced*; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D006224:Cricetinae; D004357:Drug Synergism; D007262:Infusions, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines / Q000494:pharmacology / Q000633:toxicity*; D009696:Nucleic Acids / Q000032:analysis; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D010189:Pancreatic Juice / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D012633:Secretin / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D012636:Secretory Rate / Q000187:drug effects
D001639:Bicarbonates; D009602:Nitrosamines; D009696:Nucleic Acids; D012633:Secretin; C013622:nitrosobis(2-oxopropyl)amine