title: NSAID induced avascular necrosis and arthropathy of femoral head.
abstract: The authors present the case of an 81-year-old woman with pain in her left hip. X-ray showed moderate osteoarthritic changes. The patient was prescribed diclofenal sodium (Voltaren), a nonsteroidal anti-inflammatory drug (NSAID). The patient continued use of the drug and returned 18 months later complaining of severe hip pain and difficulty in walking. X-ray, at that time, showed necrosis of the femoral head with subluxation and formation of a pseudoacetabulum. Total hip replacement was performed and the patient resumed normal daily activity. The authors point out that avascular necrosis of the femoral head, a known complication of steroid therapy, can also be caused by NSAID therapy and urge physicians to be aware of this complication.
authors.affiliation: Department of Orthopaedic Surgery, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Liebergall
authors.forename: Y
authors.initials: Y
authors.lastname: Floman
authors.forename: C
authors.initials: C
authors.lastname: Milgrom
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004008:Diclofenac / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005271:Femur Head Necrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000601:surgery; D006622:Hip Prosthesis; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy; D011859:Radiography
chemical_list: D004008:Diclofenac