Effect of forphenicinol on the production of Ia-positive macrophages in mice with or without L1210 leukemia and on the growth of L1210 in immunized mice.
Oral administration of forphenicinol, S-2-(3-hydroxy-4-hydroxymethylphenyl)glycine, increased the production of Ia-positive peritoneal macrophages in healthy mice. Moreover, forphenicinol increased Ia-positive macrophages in L1210-bearing mice. Though forphenicinol was ineffective against mouse leukemia L1210 when administered alone, in combination with L1210 vaccine it prolonged the survival time of L1210-bearing mice and the increase in the number of Ia-positive macrophages in peritoneal cavity coincided with the prolongation of the survival time. These results suggest that the initial action of forphenicinol is the preferential induction of Ia-positive macrophages, which play a role in the subsequent activation of various immune responses including macrophage activation.
Okura
A
A
Arakawa
H
H
Yoshinari
T
T
Naito
K
K
Ishizuka
M
M
Takeuchi
T
T
Umezawa
H
H
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D007939:Leukemia L1210 / Q000276:immunology* / Q000628:therapy; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D014611:Vaccination
D000276:Adjuvants, Immunologic; D000903:Antibiotics, Antineoplastic; D000949:Histocompatibility Antigens Class II; C035946:forphenicinol; D005998:Glycine