Evidence following splenic radiotherapy for a highly dynamic traffic of CFU-GM between the spleen and other organs in chronic granulocytic leukaemia.
Five patients with Ph1 +ve chronic granulocytic leukaemia and massive splenomegaly were given induction therapy with splenic irradiation, and their peripheral blood leucocyte count and granulocyte macrophage progenitor (CFU-GM) concentration monitored during the following six hours. In each patient there was a greater fall in CFU-GM than would have been expected from the fall in leucocyte count, but no evidence of a plasma inhibitor was found to explain the disproportionate reduction in CFU-GM. The difference between the estimated and observed decrease in CFU-GM/1 following splenic irradiation indicates a highly dynamic traffic of CFU-GM from the spleen to other organs in chronic granulocytic leukaemia.
Morris
T C
TC
Vincent
P C
PC
Gunz
F W
FW
Sutherland
R
R
Zbroja
R
R
Irvine
A E
AE
Forrest
P R
PR
D000328:Adult; D002453:Cell Cycle / Q000528:radiation effects; D002465:Cell Movement; D003114:Colony-Forming Units Assay; D006098:Granulocytes / Q000166:cytology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology / Q000532:radiotherapy*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000473:pathology* / Q000528:radiation effects