title: The effect of metoclopramide on the Ganzfeld electroretinogram.
abstract: Antecedent light flashes enhance the amplitude of the electroretinogram (ERG) oscillatory potentials, but do not modify other ERG responses nor dark-adaptation sensory thresholds. Metoclopramide infusion (i.v.) has a generally attenuating effect on the ERG, which is more evident under conditions of dark- than light-adaptation. Metoclopramide decreases the peak amplitude of the rod b-wave and the dark-adapted cone b-wave in a similar manner; it also significantly increases the implicit time of the rod b-wave, but not of the dark-adapted cone b-wave. In addition metoclopramide reverses the enhancement of the oscillatory potentials by the antecedent light flashes.
authors.affiliation: National Eye Institute, Bethesda, Md.
authors.forename: M J
authors.initials: MJ
authors.lastname: Jaffe
authors.forename: P D
authors.initials: PD
authors.lastname: Levinson
authors.forename: R
authors.initials: R
authors.lastname: Zimmlichman
authors.forename: J C
authors.initials: JC
authors.lastname: Coen
authors.forename: C N
authors.initials: CN
authors.lastname: Karson
authors.forename: F M
authors.initials: FM
authors.lastname: de Monasterio
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D003623:Dark Adaptation; D004596:Electroretinography; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000187:drug effects / Q000502:physiology; D012160:Retina / Q000502:physiology*
chemical_list: D008787:Metoclopramide