Induction of cytochrome P-450 mediated mono-oxygenase reactions and conjugation activities in freshwater crayfish (Astacus astacus).
The inducibility of the freshwater crayfish (Astacus astacus) biotransformation enzymes with model inducers (Aroclor 1254, beta-Naphthoflavone, Phenobarbital) were investigated three days after intra cephalothoracic injection in the fasting crayfish at 5 degrees C. Of the monooxygenase activities, 7-ethoxycoumar in O-deethylase increased in the hepatopancreas significantly (p less than 0.05) after beta-naphthoflavone administration. Benzo(a)pyrene hydroxylase did not change. Aroclor 1254 and phenobarbital injection elevated hepatopancreatic glutathione S-transferase activity (p less than 0.05).
Lindström-Seppä
P
P
Hänninen
O
O
D000818:Animals; D001140:Aroclors / Q000494:pharmacology; D003400:Astacoidea / Q000201:enzymology*; D001571:Benzoflavones / Q000494:pharmacology; D001711:Biotransformation; D020111:Chlorodiphenyl (54% Chlorine); D003577:Cytochrome P-450 Enzyme System; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008099:Liver / Q000201:enzymology; D008297:Male; D010105:Oxygenases / Q000096:biosynthesis*; D010179:Pancreas / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology; D019324:beta-Naphthoflavone
D001140:Aroclors; D001571:Benzoflavones; D020111:Chlorodiphenyl (54% Chlorine); D019324:beta-Naphthoflavone; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D010634:Phenobarbital