title: Parametric imaging of experimentally simulated Wolff-Parkinson-White syndrome conduction abnormalities in dogs: a concise communication.
abstract: In order to test the diagnostic potential of phase analysis of radionuclide ventriculography (RNV) for localizing accessory bundles in Wolff-Parkinson-White (WPW) syndrome, 24 experimental runs were performed in three open chest instrumented dogs. After a baseline study, WPW syndrome was simulated by stimulation at seven different sites around the base of the ventricles, and RNV's were obtained. Subsequent data processing including Fourier transformation allowed the localization of the site of the first inward motion of the ventricles by an isophasic wave display. In sinus rhythm, the septum contracted first. During ectopic premature ventricular stimulation by triggering the atrial signal, the phase scan was altered only when the stimulus was applied earlier than 20 ms before the expected QRS complex during sinus rhythm. During stimulation with fixed frequency, only the left lateral positions of the premature stimulation were detected by phase analysis with a sensitivity of 86%. Neither the antero- or posteroseptal nor the right ventricular premature contraction pattern could be exactly localized.
authors.affiliation: Section of Cardiology, Angiology and Pulmonology, Centre of Internal Medicine, University of Ulm, West Germany.
authors.forename: P
authors.initials: P
authors.lastname: Weismüller
authors.forename: E
authors.initials: E
authors.lastname: Henze
authors.forename: W E
authors.initials: WE
authors.lastname: Adam
authors.forename: J
authors.initials: J
authors.lastname: Roth
authors.forename: F
authors.initials: F
authors.lastname: Bitter
authors.forename: M
authors.initials: M
authors.lastname: Stauch
mesh_terms: D000818:Animals; D004285:Dogs; D006329:Heart Conduction System / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008722:Methods; D011877:Radionuclide Imaging; D013667:Technetium; D016698:Technetium Tc 99m Pyrophosphate; D014003:Tin Polyphosphates; D014927:Wolff-Parkinson-White Syndrome / Q000000981:diagnostic imaging* / Q000503:physiopathology
chemical_list: D014003:Tin Polyphosphates; C017742:technetium Tc 99m stannous pyrophosphate; D016698:Technetium Tc 99m Pyrophosphate; D013667:Technetium