title: Platelet peroxidase of circulating thrombocytes in acquired refractory anaemias.
abstract: The platelet peroxidase (PPO) content of circulating thrombocytes was determined in 10 healthy controls and in 18 cases of acquired refractory anaemia (2 with refractory anaemia, 4 with sideroblastic refractory anaemia, 8 with refractory anaemia with excess of blasts, 3 with refractory anaemia in transformation and 1 with chronic myelomonocytic leukaemia). The thrombocytes of the controls were invariably PPO-positive. No peroxidase deficiency was found in the 4 patients with sideroblastic refractory anaemia. Of the remaining 14 cases PPO-positive and PPO-negative thrombocytes coexisted in 8. Only in 1 case of refractory anaemia with excess of blasts were circulating platelet peroxidase-positive micromegakaryocytes demonstrated. PPO deficiency seems to be an important dysthrombopoietic feature detectable only at an ultrastructural level.
authors.forename: S
authors.initials: S
authors.lastname: Woessner
authors.forename: R
authors.initials: R
authors.lastname: Lafuente
authors.forename: L
authors.initials: L
authors.lastname: Florensa
mesh_terms: D000740:Anemia / Q000201:enzymology*; D000756:Anemia, Sideroblastic / Q000201:enzymology; D001792:Blood Platelets / Q000201:enzymology* / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood; D008854:Microscopy, Electron; D010544:Peroxidases / Q000097:blood*
chemical_list: D010544:Peroxidases