The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis.
Endogenous prostaglandins (PGs) have been isolated in large amounts from the gastrointestinal tract of man. These substances are intimately related to muscle contraction and cytoprotection. The gastric juice and serum levels of PGE2 and F2 alpha have been assayed in nine infants with infantile hypertrophic pyloric stenosis (IHPS) and seven age-matched controls. The gastric juice levels were significantly raised in the IHPS group for both PGE2 (P = 0.001) and PGF2 alpha (P = 0.02) as compared to controls. The possible role of PGs in the etiology of IHPS is discussed.
LaFerla
G
G
Watson
J
J
Fyfe
A H
AH
Drainer
I K
IK
D015237:Dinoprost; D015232:Dinoprostone; D005260:Female; D005745:Gastric Acidity Determination; D006801:Humans; D006984:Hypertrophy / Q000097:blood; D007223:Infant; D008297:Male; D011458:Prostaglandins E / Q000032:analysis / Q000097:blood*; D011460:Prostaglandins F / Q000032:analysis / Q000097:blood*; D011707:Pyloric Stenosis / Q000097:blood*; D012737:Sex Factors
D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D015232:Dinoprostone