Pharmacokinetic studies of imipenem/cilastatin in elderly patients.
Six patients, aged between 68 and 83 years, with glomerular filtration rates (GFR) between 31 and 80 ml/min received imipenem/cilastatin as treatment for acute lower respiratory tract infection. A combination of 500 mg of both agents was administered, 6-hourly, intravenously over 30 min. After a minimum of four doses, blood specimens were obtained for assay of imipenem and cilastatin concentrations by HPLC. Pharmacokinetic parameters were calculated from the results. The mean half life was 1.6 h for imipenem and 2.1 h for cilastatin, values similar to those reported for patients with moderate renal impairment. Elimination constant, clearance and AUC significantly correlated with GFR but not with age. No accumulation was observed.
Finch
R G
RG
Craddock
C
C
Kelly
J
J
Deaney
N B
NB
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015377:Cilastatin; D003521:Cyclopropanes / Q000097:blood / Q000378:metabolism*; D004150:Dipeptidases / Q000037:antagonists & inhibitors*; D005919:Glomerular Filtration Rate; D006801:Humans; D015378:Imipenem; D007700:Kinetics; D013845:Thienamycins / Q000097:blood / Q000378:metabolism*
D003521:Cyclopropanes; D013845:Thienamycins; D015377:Cilastatin; D015378:Imipenem; D004150:Dipeptidases