title: Sex differences in the effect of uric acid on the survival of analbuminemic rats exposed to cold: effects of gonadal hormones and uric acid.
abstract: When female analbuminemic rats were injected with 0.8 mg uric acid every 3 h, their survival time at 5 degrees C increased from 14 h to 28 h, but uric acid had no effect on analbuminemic male rats. When female rats were oophorectomized 1 week before cold exposure, the injection of uric acid had no effect on their survival. Furthermore, uric acid did not increase the survival of the female rats that were administered a pellet containing 5 mg testosterone 1 week before the cold exposure. When the male rats were castrated 1 week before cold exposure, their survival time decreased from 20 h to 14 h, and administrations of 5 mg estradiol pellet at the time of castration and 0.8 mg uric acid every 3 h during cold exposure increased their survival time to 23 h.
authors.affiliation: Department of Physiology, Wakayama Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: M
authors.initials: M
authors.lastname: Shimode
authors.forename: H
authors.initials: H
authors.lastname: Matsushita
authors.forename: S
authors.initials: S
authors.lastname: Nagase
mesh_terms: D000818:Animals; D002369:Castration; D003080:Cold Temperature / Q000009:adverse effects*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics; D012709:Serum Albumin / Q000172:deficiency*; D012727:Sex Characteristics; D013739:Testosterone / Q000494:pharmacology; D014527:Uric Acid / Q000494:pharmacology*
chemical_list: D012739:Gonadal Steroid Hormones; D012709:Serum Albumin; D014527:Uric Acid; D013739:Testosterone; D004958:Estradiol