title: A preliminary metabolic study of alpidem in rat and man.
abstract: The metabolism of alpidem, a new anxiolytic agent in the chemical series of imidazopyridines, was investigated in rat and man. In both species the compound is extensively metabolised by three main routes of biotransformation: aromatic oxidation of the imidazopyridine ring; n-dealkylation; and/or aliphatic oxidation of the substituted amide side chains.
authors.affiliation: Laboratoire d'Etudes et de Recherches Synthélabo Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Padovani
authors.forename: P
authors.initials: P
authors.lastname: Guinebault
authors.forename: S
authors.initials: S
authors.lastname: Vajta
authors.forename: A
authors.initials: A
authors.lastname: Durand
authors.forename: J
authors.initials: J
authors.lastname: Allen
authors.forename: J P
authors.initials: JP
authors.lastname: Thenot
authors.forename: P L
authors.initials: PL
authors.lastname: Morselli
mesh_terms: D000328:Adult; D000818:Animals; D001646:Bile / Q000032:analysis; D001711:Biotransformation / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000032:analysis / Q000378:metabolism* / Q000652:urine; D008297:Male; D011725:Pyridines / Q000032:analysis / Q000378:metabolism* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
chemical_list: D007093:Imidazoles; D011725:Pyridines; C052036:alpidem