title: The development of enzyme catalytic efficiency: an experimental approach.
authors.affiliation: Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138.
authors.forename: J D
authors.initials: JD
authors.lastname: Hermes
authors.forename: S C
authors.initials: SC
authors.lastname: Blacklow
authors.forename: J R
authors.initials: JR
authors.lastname: Knowles
mesh_terms: D001665:Binding Sites; D005075:Biological Evolution; D002384:Catalysis; D004798:Enzymes / Q000378:metabolism*; D007700:Kinetics; D008958:Models, Molecular; D008962:Models, Theoretical; D009154:Mutation; D011487:Protein Conformation; D013816:Thermodynamics; D014305:Triose-Phosphate Isomerase / Q000378:metabolism
chemical_list: D004798:Enzymes; D014305:Triose-Phosphate Isomerase