Cytogenetic investigations in childhood chronic myelocytic leukemia.
Cytogenetic studies were performed on 25 chronic myelogenous leukemia patients aged between 6 mo and 19 yr. Of these, 14 presented with the adult form and 11 with the juvenile form of the disease. In patients with the adult type, 12 of 14 had a Ph chromosome and additional anomalies appearing during blastic transformation. In patients with the juvenile form, 6 of 11 had a monosomy 7 and a short survival time (median 10 mo). Salient features of these patients, as well as a survey of the pertinent literature on the subject, are presented in this paper.
Ghione
F
F
Mecucci
C
C
Symann
M
M
Michaux
J L
JL
Casteels-Van Daele
M
M
Van den Berghe
H
H
D000293:Adolescent; D000328:Adult; D001772:Blood Cell Count; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000097:blood / Q000145:classification / Q000235:genetics* / Q000401:mortality; D008297:Male; D009006:Monosomy; D010677:Philadelphia Chromosome