title: The effects of metamizol on prostaglandin synthesis in man.
abstract: Clinical pharmacological investigations on the inhibition of prostaglandin synthesis are presented, comparing metamizol and indomethacin with respect to platelet aggregation, platelet thromboxane synthesis, total body PGE2-synthesis and side effects. Prostaglandin synthesis is clearly and persistently inhibited by metamizol in man.
authors.forename: J C
authors.initials: JC
authors.lastname: Frölich
authors.forename: W A
authors.initials: WA
authors.lastname: Rupp
authors.forename: R M
authors.initials: RM
authors.lastname: Zapf
authors.forename: M J
authors.initials: MJ
authors.lastname: Badian
mesh_terms: D000527:Alprostadil / Q000096:biosynthesis; D000632:Aminopyrine / Q000031:analogs & derivatives*; D001241:Aspirin / Q000494:pharmacology; D003094:Collagen; D015232:Dinoprostone; D004177:Dipyrone / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects; D007700:Kinetics; D010974:Platelet Aggregation / Q000187:drug effects; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis; D013931:Thromboxanes / Q000096:biosynthesis
chemical_list: D011453:Prostaglandins; D011458:Prostaglandins E; D013931:Thromboxanes; D000632:Aminopyrine; D004177:Dipyrone; D003094:Collagen; D000527:Alprostadil; D015232:Dinoprostone; D001241:Aspirin; D007213:Indomethacin