Rapidly progressive myelomonocytic leukemia (juvenile CML).
A rare type of rapidly fatal childhood leukemia, generally called juvenile chronic myelogenous leukemia, is characterized by absence of the Philadelphia chromosome and a predominantly monocytic proliferation, among other features. Unlike Philadelphia chromosome positive chronic myelogenous leukemia, this disease is neither chronic nor principally a disorder of granulocytic cell lines. A case is presented, with several clinical and laboratory parameters useful in establishing the correct diagnosis, and a change in terminology to "rapidly progressive juvenile myelomonocytic leukemia" is proposed.
Bacon
D R
DR
Mosijczuk
A D
AD
Humberd
Q A
QA
D002648:Child; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology* / Q000503:physiopathology; D010677:Philadelphia Chromosome