title: Discharge characteristics of receptors with fine afferents from normal and inflamed joints: influence of analgesics and prostaglandins.
abstract: This contribution presents several aspects of our work which are relevant in order to understand how pyrazolone drugs act. They include the discharge characteristics of individual fine afferent nerve fibres from the normal intact joint, the changes that acute experimental inflammation can induce in them, and the effects of prostaglandins and non-steroidal anti-inflammatory drugs.
authors.forename: H G
authors.initials: HG
authors.lastname: Schaible
authors.forename: R F
authors.initials: RF
authors.lastname: Schmidt
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000344:Afferent Pathways; D000527:Alprostadil / Q000494:pharmacology; D000818:Animals; D001168:Arthritis / Q000503:physiopathology*; D001241:Aspirin / Q000494:pharmacology; D002415:Cats; D015232:Dinoprostone; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation / Q000503:physiopathology; D007719:Knee Joint / Q000294:innervation* / Q000503:physiopathology; D009068:Movement; D009431:Neural Conduction / Q000187:drug effects; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D011458:Prostaglandins E / Q000494:pharmacology
chemical_list: D011458:Prostaglandins E; D000527:Alprostadil; D015232:Dinoprostone; D001241:Aspirin; D007213:Indomethacin