Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion.
Tumor cells grown in the presence of 1-O-alkyl-2-O-methylglycero-3-phosphocholine (AMG-PC) accumulated this ether lipid in their membranes. Depending on the cell type and the dose of the compound, up to 17% of the total phospholipids of the purified plasma membranes consisted of authentic AMG-PC. Extensive incorporation of the agent resulted in a decrease in plasma membrane fluidity and inhibition of tumor cell invasiveness in embryonic chick heart fragments. The extent of AMG-PC incorporation and fluidity change was not strictly correlated with the degree to which tumor cell invasion was inhibited.
van Blitterswijk
W J
WJ
Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam.
Hilkmann
H
H
Storme
G A
GA
D000818:Animals; D002460:Cell Line; D005995:Glyceryl Ethers / Q000493:pharmacokinetics* / Q000494:pharmacology; D008560:Membrane Fluidity / Q000187:drug effects*; D010742:Phospholipid Ethers / Q000493:pharmacokinetics* / Q000494:pharmacology; D051381:Rats; D013347:Subcellular Fractions / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014410:Tumor Stem Cell Assay
D005995:Glyceryl Ethers; D010742:Phospholipid Ethers