Assessment of central dopaminergic function using plasma-free homovanillic acid after debrisoquin administration.
Central dopaminergic (DA) function in children and adults was assessed by monitoring plasma-free levels of the dopamine metabolite homovanillic acid (pHVA) before and after a single oral dose and chronic oral administration of debrisoquin. Debrisoquin inhibits peripheral metabolism of dopamine to HVA and does not cross the blood-brain barrier. By reducing peripheral formation of HVA through the use of debrisoquin, the remaining HVA in plasma more accurately reflects central DA activity. Debrisoquin administration resulted in marked reductions of pHVA in each of 12 patients studied. Eleven of the 12 subjects tolerated debrisoquin without physical or behavioral side effects. The debrisoquin administration method appears to be a safe and potentially valid technique for evaluating aspects of central dopaminergic function in children and adults.
Riddle
M A
MA
Leckman
J F
JF
Cohen
D J
DJ
Anderson
M
M
Ort
S I
SI
Caruso
K A
KA
Shaywitz
B A
BA
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D002648:Child; D003647:Debrisoquin / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism* / Q000502:physiology; D005260:Female; D006719:Homovanillic Acid / Q000097:blood*; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D005879:Tourette Syndrome / Q000378:metabolism
D007546:Isoquinolines; D004298:Dopamine; D003647:Debrisoquin; D006719:Homovanillic Acid