Serum bilirubin after surgery for obstructive jaundice.
A method of analysis of bilirubin clearance is suggested, which allows the calculation of a decay constant (k) and half-life (t0.5). These parameters allow ready comparison of the bilirubin clearance between patient groups. The value of k could be predicted with reasonable accuracy by a regression equation employing as determinants a score for cholangitis, pre-operative serum ALT and bilirubin, and the patient's sex. Bilirubin clearance is known to correlate strongly with antipyrine clearance, and antipyrine clearance with prognosis after biliary drainage. A similar prognostic index may be derived from simple clinical and biochemical parameters which will predict the decay constant and half-life of endogenous bilirubin.
Little
J M
JM
Robotin
M
M
D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood*; D002779:Cholestasis / Q000097:blood / Q000601:surgery*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011379:Prognosis; D012044:Regression Analysis; D012737:Sex Factors; D013997:Time Factors
D001663:Bilirubin