Remarkable catch-up growth in a boy with steroid-responsive nephrotic syndrome.
A boy is described who was followed from 4 to 21.5 years of age, during which time he was treated with high doses of corticosteroids for a steroid-responsive nephrotic syndrome. For the first 10 years therapy was mainly continuous and height decreased from -0.5 to -4.5 SDS. Later discontinuous treatment without a reduction in the total weekly dose was accompanied by rapid catch-up growth. Final height was -1.0 SDS. During most of the time skeletal age was severely retarded and a discrepancy between the development of the short bones of the hand and the carpal bones was noted.
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D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D000365:Age Determination by Skeleton; D001827:Body Height; D002675:Child, Preschool; D006128:Growth; D006130:Growth Disorders / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D011241:Prednisone