title: [Epidemiologic study of atopic environment in Lorraine].
abstract: An epidemiology study on atopy was performed in a Center of Preventive Medicine, in 505 children aged from 4 to 14 years old, in good health, in consultation with their parents. The clinical atopy was evaluated by a questionnaire inquiring about atopic dermatitis, hay fever, infantile asthma, previous recurrent infections, breast or bottle feeding. Total serum IgE were dosed (Phadezym) and pricks performed to mites and pollens. The clinical atopy is diagnosed in 14.46% of cases (atopic dermatitis: 10.28%--asthma: 3.76%--hay fever: 2/98%). Pricks are positive in 14.85% of cases (mites: 11.48%--pollen: 99.11%--both: 5.74%). The cutaneous sensibility is observed in 32.8% of cases with clinical atopy, 12.5% of other children. The total IgE are very variable and does not correlate with a normal distribution. This allows definition of the quartile below which 90% of the sample is to be found: 474 kUI/l. There is a highly significant relation (p 0.001) between clinical atopy and positive pricks to airborne allergens, clinical atopy and raised alone 474 kUI/l, positive pricks and IgE of more than 474 kUI/l. There is a close relation between atopy and recurrent infections, raised IgE in children and paternal atopy, specific IgE in children and maternal atopy. It appears also that breast feeding is a risk factor for raised IgE in children when the mothers are not atopic, which is somewhat unexpected. Investigation of an atopic terrain may be performed through skin tests or an assay of seric IgE, which seem to be closely comparable.
authors.affiliation: Service de Médecine "D", C.H.U., Vandoeuvre-Lès-Nancy.
authors.forename: D A
authors.initials: DA
authors.lastname: Moneret-Vautrin
authors.forename: F
authors.initials: F
authors.lastname: Schiele
authors.forename: J
authors.initials: J
authors.lastname: Locuty
authors.forename: T
authors.initials: T
authors.lastname: Mikstacki
authors.forename: M M
authors.initials: MM
authors.lastname: Galteau
authors.forename: J P
authors.initials: JP
authors.lastname: Grilliat
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000175:diagnosis / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004485:Eczema / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D005602:France; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000453:epidemiology*; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E
vernacular_title: Etude épidémiologique du terrain atopique en Lorraine.