Clinical characteristics and mechanisms involved in chemotherapy-induced oral ulceration.
The clinical characteristics of chemotherapy-induced oral mucosal ulceration in a group of patients with acute leukemia were examined in detail in a long-term prospective clinical study. Differences in regional susceptibility within the mouth to the effects of chemotherapy were apparent. A reconstruction of the probable mechanisms involved is presented.
Barrett
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AP
D000208:Acute Disease; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D004334:Drug Administration Schedule; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D009059:Mouth Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D011446:Prospective Studies; D014456:Ulcer / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology