Acute tumour lysis syndrome with extreme metabolic abnormalities.
Tumour lysis syndrome, manifested by various metabolic derangements, is a known complication after treatment of some lymphoid malignancies. A patient is reported with acute lymphocytic leukaemia who developed a tumour lysis syndrome following intensive chemotherapy. All the known complications of the syndrome were present in the most severe form--hyperuricaemia of 1.44 mmol/l, hyperphosphataemia of 7.7 mmol/l with acute oliguric renal failure and extreme hyperkalaemia of 9.8 mmol/l with electrocardiographic changes. This life-threatening condition did not respond to conservative measures and the patient recovered only after haemodialysis.
Leonov
Y
Y
Golik
A
A
Kaufman
S
S
Gilboa
Y
Y
D000328:Adult; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D006934:Hypercalcemia / Q000150:complications*; D006947:Hyperkalemia / Q000150:complications*; D006996:Hypocalcemia / Q000150:complications; D007945:Leukemia, Lymphoid / Q000150:complications / Q000188:drug therapy*; D008297:Male; D010257:Paraneoplastic Syndromes / Q000503:physiopathology; D010710:Phosphates / Q000097:blood; D014527:Uric Acid / Q000097:blood
D010710:Phosphates; D014527:Uric Acid