Increased platelet thromboxane B2 production in newborn infants of diabetic mothers.
Platelet thromboxane B2 (TxB2) production, plasma concentrations of C-peptide and pancreatic glucagon as well as blood glucose levels were measured in 12 infants of insulin-dependent diabetic mothers and eight healthy controls at the age of two hours. Platelet TxB2 production (p less than 0.05) and plasma C-peptide levels (p less than 0.02) were significantly higher and blood glucose concentrations lower (p less than 0.002) in the infants of the diabetic mothers than in the controls. The data suggest that platelets of infants of diabetic mothers produce increased amounts of proaggregatory thromboxane A2, which may contribute to the hyperaggregation in these infants.
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Knip
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Viinikka
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Ylikorkala
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D001786:Blood Glucose / Q000032:analysis; D001792:Blood Platelets / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D010179:Pancreas / Q000378:metabolism; D013929:Thromboxane B2 / Q000378:metabolism*
D001786:Blood Glucose; D002096:C-Peptide; D013929:Thromboxane B2; D005934:Glucagon