Synthesis, DNA binding and antiviral activity of distamycin analogues containing different heterocyclic moieties.
A series of novel distamycin analogues possessing an additional benzene or heterocyclic ring have been synthesised and tested for selective DNA binding properties and antiviral activity. Inhibition of herpes virus in cell culture appears to be related to AT base pair specificity. Some of the new compounds are also more potent than the parent distamycin against Moloney sarcoma virus.
Arcamone
F
F
Ricerca & Sviluppo Chimico, Farmitalia Carlo Erba, Milan, Italy.
Lazzari
E
E
Menozzi
M
M
Soranzo
C
C
Verini
M A
MA
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D001483:Base Sequence; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D004214:Distamycins / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D004214:Distamycins; D011758:Pyrroles; D004247:DNA