Improvement of post platelet transfusion increments following intravenous immunoglobulin therapy for leukaemic HLA-immunized patients.
3 patients with acute leukaemia, HLA antibodies and thrombocytopenia refractory to random donor platelet transfusions were treated with high-dose i.v. immunoglobulin. All 3 patients responded favourably with improved post-transfusion recovery of random platelets. In 1 patient, the recovery of transfused histocompatible platelets was also enhanced. Treatment was followed by reduction in the total lymphocyte count and marked changes in lymphocyte subsets in 1 patient.
Atrah
H I
HI
Sheehan
T
T
Gribben
J
J
Crawford
R J
RJ
O'Donnel
J R
JR
Sandilands
G P
GP
D000328:Adult; D000368:Aged; D001803:Blood Transfusion; D006680:HLA Antigens / Q000276:immunology*; D006689:Hodgkin Disease / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage*; D007167:Immunotherapy; D015470:Leukemia, Myeloid, Acute / Q000276:immunology / Q000628:therapy*; D008297:Male; D017713:Platelet Transfusion
D006680:HLA Antigens; D007136:Immunoglobulins