title: Frequency of hypoglycemia in children with adrenal insufficiency.
abstract: The frequency of hypoglycemia in 165 children with primary adrenal insufficiency, 118 of whom had Congenital Adrenal Hyperplasia and 47 Addison's Disease, was 18%. Half of the hypoglycemic episodes occurred in the neonatal period. Hypoglycemia was isolated in 13 children, revealing the disease in 4 newborns with Congenital Adrenal Hypoplasia and in a boy with 11 B Hydroxylase deficiency. Basal plasma cortisol levels were significantly lower in those of subjects who experienced hypoglycemia (47.1 +/- 28.6 ng/ml vs. 106.0 +/- 86.6 ng/ml, p less than 0.001). A significant correlation (p less than 0.001) was found between the plasma concentration of glucose and cortisol at time of hypoglycemia.
authors.forename: E
authors.initials: E
authors.lastname: Artavia-Loria
authors.forename: J L
authors.initials: JL
authors.lastname: Chaussain
authors.forename: P F
authors.initials: PF
authors.lastname: Bougnères
authors.forename: J C
authors.initials: JC
authors.lastname: Job
mesh_terms: D000224:Addison Disease / Q000150:complications; D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000150:complications; D000309:Adrenal Insufficiency / Q000097:blood / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007003:Hypoglycemia / Q000209:etiology*; D007223:Infant; D007231:Infant, Newborn
chemical_list: D006854:Hydrocortisone