New variant translocation (1;8;21) in a case of acute myeloblastic leukemia (M2).
A new translocation involving chromosome #1, #8, and #21 in a patient with type M2 acute myeloblastic leukemia is reported. The breakpoint of #1 in this case was at band p13 and differed from that in two previously reported cases of t(1;8;21) involving the long arm of #1. A key event leading to the development of the M2 phenotype appears to be a break at band q22 of #8 with associated translocation of the terminal end of the long arm of #21.
Taguchi
H
H
Kitagawa
T
T
Yamashita
M
M
Kubonishi
I
I
Miyoshi
I
I
D000328:Adult; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic
D005819:Genetic Markers