title: Prenatal fate of parthenogenetic cells in mouse aggregation chimaeras.
abstract: Parthenogenetically activated BCF1 and fertilized BALB/c embryos were aggregated to form chimaeras. The fate of the parthenogenetic component was followed in the conceptus during the second half of gestation. The results indicate an early strong selection against parthenogenetic cells in the extra-embryonal part, which is presumably complete by term, and a weaker selective process in the embryo. During early development, parthenogenetic cells have nearly normal developmental potency in the embryo, which allows their balanced contribution in the chimaeras on day 12. Later, this contribution declines significantly resulting in an unbalanced relation to the advantage of the fertilized counterpart. From the results, we suggest that gametic imprinting may play a role not only in the key steps of preimplantation and early postimplantation development, but later in cell and tissue differentiation.
authors.affiliation: Department of Behaviour Genetics, L. Eötvös University, Göd, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Nagy
authors.forename: A
authors.initials: A
authors.lastname: Páldi
authors.forename: L
authors.initials: L
authors.lastname: Dezso
authors.forename: L
authors.initials: L
authors.lastname: Varga
authors.forename: A
authors.initials: A
authors.lastname: Magyar
mesh_terms: D000367:Age Factors; D000818:Animals; D002449:Cell Aggregation; D002678:Chimera; D005314:Embryonic and Fetal Development; D051379:Mice; D008807:Mice, Inbred BALB C; D010312:Parthenogenesis