Serum levels of the carbohydrate antigen CA-50 in pancreatic disease.
A monoclonal antibody (C 50) was recently produced by immunization with a colorectal cell line defining the tumour associated carbohydrate antigen CA-50. In previous studies CA-50 in serum has been elevated in 60-70% of patients with gastrointestinal carcinomas. This study surveys the serum levels of CA-50, as determined by a radioimmunoassay, in pancreatic disease. Elevated levels of CA-50 were found in 22 of the 24 patients with carcinoma of the exocrine pancreas, in one of eight patients with chronic pancreatitis, and in six of fourteen attacks (41%) of acute pancreatitis. The serum CA-50 antigen, as determined by the assay employed here, has a high sensitivity (92%) for exocrine pancreatic carcinoma. Only patients with malignant disease had CA-50 values exceeding 43 units per ml. In 58% of the patients with pancreatic carcinoma (14/24), CA-50 values surpassed 43 units per ml. In the presence of a pancreatic mass, marked elevation seems to support diagnosis of carcinoma. The low positive predictive value makes the assay unsuitable as a screening test for detection of pancreatic carcinoma in a general population.
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Dahlgren
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D000208:Acute Disease; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000276:immunology*; D010195:Pancreatitis / Q000276:immunology*; D011863:Radioimmunoassay
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate