Autoradiographic study of cell proliferation in acanthotic buccal epithelium of zinc-deficient rabbits.
A zinc-deficient diet for 3 weeks led to acanthotic, hyperparakeratotic buccal epithelium in which the labelling and mitotic indices were increased. The total cell-cycle time was greatly reduced due to reduction in the transit time of the GI phase and, to a lesser extent, of the S and G2 phases. The results cannot be explained by decreased activity of DNA synthesis. They may be due to loss of growth inhibition in oral epithelium.
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D000818:Animals; D001345:Autoradiography; D001835:Body Weight; D002453:Cell Cycle; D002455:Cell Division; D002610:Cheek; D008297:Male; D008940:Mitotic Index; D009061:Mouth Mucosa / Q000166:cytology*; D011817:Rabbits; D015032:Zinc / Q000172:deficiency*
D015032:Zinc