Tolerance or hyperreactivity to interferon induction by sodium salt of 9-oxo-10-acridineacetic acid and analogs in mice and in the mouse macrophage cultures.
Choline and halogen analogs of 9-oxo-10-acridineacetic acid (CMA) were studied as IFN inducers in mice and in the mouse bone marrow-derived macrophage cultures. Two of the choline analogs--DMCMA and CSCMA were inducers of IFN in the macrophages. The response was found to be dose related. CMA as well as the active analogs were found to induce the hyporeactive state to IFN induction both in mice and in the mouse macrophage cultures. On the other hand, the inhibitor of IFN induction by CMA--the dibromo analog (DBCMA) was found to induce in mice a hyperreactive state to IFN induction by CMA.
Szulc
B
B
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Inglot
A D
AD
Inglot
O
O
D000166:Acridines / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D004361:Drug Tolerance; D007369:Interferon Inducers; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D000166:Acridines; D007369:Interferon Inducers; C055377:N,N-(dimethylamino)ethyl 9-oxo-10-acridineacetate; C055378:cholinium 9-oxo-10-acridineacetate; C055379:2,7-dibromo-9-oxo-10-acridineacetate; C026430:10-carboxymethyl-9-acridanone