[Acromegaly and colorectal proliferations].
Hypersomatotropism causes not only the typical acromegalic symptoms but also very often a splanchnomegaly with participation of the enteron. We performed a colonoscopy in 16 patients with a persistent active acromegaly in spite of full used therapy possibilities. Only in four cases (25%) we could find a polyp. They were distributed on the colon transversum (one), descendens (one) and sigmoideum (two). Three of them (histology: tubular adenoma) had a diameter of less than 5 mm. Only one adenoma had an extent of 3.5 x 3 x 2.5 cm (histology: tubular-villous adenoma). Not any polyp showed signs of malignity. There existed no relations between the coloscopic findings, the degree of activity and the duration of illness. Localisation, histology, frequency and age distribution of the found out polyps of our patients were in the range of real frequency of the occurrence of colorectalic neoplasms. We conclude: Acromegaly is correlated not more than accidentally with colorectalic neoplasms (benign, malignant). Therefore preventive medical examinations of acromegalic patients are not rich in meaning.
Hampel
R
R
Abteilung für Endokrinologie und Stoffwechselkrankheiten, Bereichs Medizin der Ernst-Moritz-Arndt-Universität Greifswald.
Ventz
M
M
Hesse
R
R
D000172:Acromegaly / Q000473:pathology*; D000328:Adult; D003106:Colon / Q000473:pathology; D003111:Colonic Polyps / Q000473:pathology*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007417:Intestinal Polyps / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000473:pathology*; D012007:Rectum / Q000473:pathology
Akromegalie und kolorektale Proliferationen.