title: [Acute myelogenous leukemia with only a 5q-chromosome abnormality].
abstract: A 68-year-old man with acute myelogenous leukemia (M2) was induced to complete remission by chemotherapy consisting of BH-AC and ACM-A on the 180th hospital day. Prior to therapy, chromosome analysis revealed 46, XY, del(5)(q22q33). No additional chromosome abnormalities were noted. Though 5q- was first associated with a preleukemic state, it is now known to be found in several different hematological disease. It has been suggested that patients with only a 5q- abnormality might have a better prognosis than those with a 5q- plus additional chromosome abnormalities. 5q- usually results from an interstitial deletion with break and fusion points at 5q11 or 12, 5q14 or 15, 5q22 and 5q33 or 35. The c-fms oncogene is located in the vicinity of band 5q34, so that a chromosome break at 5q33 or 34 may play an important role in the hematological disorders with 5q- chromosome abnormality.
authors.forename: T
authors.initials: T
authors.lastname: Maekawa
authors.forename: H
authors.initials: H
authors.lastname: Fujii
authors.forename: M
authors.initials: M
authors.lastname: Kashiwadani
authors.forename: Y
authors.initials: Y
authors.lastname: Suyama
authors.forename: M
authors.initials: M
authors.lastname: Iwai
authors.forename: M
authors.initials: M
authors.lastname: Miyoshi
authors.forename: K
authors.initials: K
authors.lastname: Nishida
authors.forename: S
authors.initials: S
authors.lastname: Horiike
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male