title: Factors affecting retention of Cu in the human oral cavity after mouth rinses.
abstract: Retention of Cu in the mouth after rinses with aqueous solutions of CuSO4 was measured by atomic absorption spectrophotometry. The retained amount of Cu exhibited a linear relationship against the concentration of the rinsing solution in the range tested. Approximately one third of the Cu retained after a 60 s rinse was retained within the first 15 s, and about 75% within 30 s. Retention of Cu was only little affected by the pH of the rinsing solution in the range from 2.0 to 5.7, being reduced by about 50% at pH 9.0. However, variations in cupric ion activity rather than pH per se could explain these effects. A mutual reduction in retention of either metals was seen when Cu and Zn were applied simultaneously.
authors.forename: J
authors.initials: J
authors.lastname: Afseth
authors.forename: K
authors.initials: K
authors.lastname: Helgeland
mesh_terms: D003300:Copper / Q000008:administration & dosage / Q000378:metabolism*; D019327:Copper Sulfate; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009061:Mouth Mucosa / Q000378:metabolism*; D009067:Mouthwashes; D013054:Spectrophotometry, Atomic; D013997:Time Factors; D015032:Zinc / Q000378:metabolism / Q000494:pharmacology
chemical_list: D009067:Mouthwashes; D003300:Copper; D015032:Zinc; D019327:Copper Sulfate