[Augmentation of natural killer (NK) cell activity in human blood lymphocytes by a new synthetic acyltripeptide (FK-565) and its derivatives].
Natural killer (NK) activities of human blood lymphocyte populations that were depleted of monocytes by centrifugal elutriation, were significantly augmented by in vitro treatment with synthetic acyltripeptide (FK-565) at concentrations ranging from 10 micrograms/ml to 100 micrograms/ml in medium. Of FK-565 and its eight derivatives, FR-39868 was the most effective in potentiating human NK cell activity, and caused NK cell-mediated cytotoxicity against K-562 target cells even at a minimal concentration of 1 microgram/ml. The significant levels of cytotoxicity, increased with increasing NK cell/target ratio. These results indicate that acyltripeptide and its derivatives should be useful in enhancing natural host defense against neoplasias in vivo.
Shimizu
E
E
Tandon
P
P
Utsugi
T
T
Sone
S
S
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D002460:Cell Line; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000276:immunology*; D009842:Oligopeptides / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D009842:Oligopeptides; C039537:heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine