Breakpoints in variant Philadelphia translocations in chronic myeloid leukemia.
To date, 327 cases of variant Philadelphia translocations found in chronic myeloid leukemia have been described. A statistical analysis using the Monte Carlo simulation was performed to determine which chromosomal bands were preferentially involved in variant Philadelphia translocations. The results showed that twenty-eight bands were significantly rearranged (P less than 0.05).
De Braekeleer
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D002871:Chromosome Banding; D014644:Genetic Variation; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic