title: Fine needle aspiration cytology of hemangioblastoma of the spinal cord. Report of a case with immunocytochemical and ultrastructural studies.
abstract: The cytologic features of a hemangioblastoma of the spinal cord diagnosed by an intraoperative fine needle aspiration (FNA) biopsy are reported in a 66-year-old man with a long-standing history of Charcot-Marie-Tooth disease. A dual population of delicate branching vascular channels associated with nearby coarsely vacuolated stromal cells was appreciated in the smears. Histologic, immunocytochemical and ultrastructural studies demonstrated three cell types comprising the tumor: endothelial cells, pericytes and stromal cells. Factor VIII-related antigen positivity, vimentin positivity and glial fibrillary acid protein negativity support the contention that all three types of tumor cells may arise from a common angiogenic mesenchymal ancestry. A discussion of the expected aspiration cytologic findings of other tumors of the spinal cord is also presented. FNA biopsy of suspected hemangioblastoma should be performed with utmost caution due to the possibility of extensive intraoperative bleeding, such as we experienced following sampling of this tumor.
authors.forename: J F
authors.initials: JF
authors.lastname: Silverman
authors.forename: D J
authors.initials: DJ
authors.lastname: Dabbs
authors.forename: J R
authors.initials: JR
authors.lastname: Leonard
authors.forename: L S
authors.initials: LS
authors.lastname: Harris
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000379:methods; D006394:Hemangiosarcoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure