Analysis of linkage with disease-marker association.
This paper proposes a method to deal with linkage analysis under the existence of association between a disease and a marker locus. We specially consider the disease as a quantitative trait. At first, we propose a so-called "a minimum sum of square errors approach" to classify individuals in a family genetically, then use the classification results to detect linkage with association by the developed method.
Tai
J J
JJ
D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D005826:Genetics, Medical / Q000379:methods; D005838:Genotype; D006801:Humans
D005819:Genetic Markers