title: [Allergic reactions to transfusion].
abstract: Frequent allergic reactions following transfusion are observed. Usually, they are benign but sometimes we observe severe allergic reactions. Adverse reactions may be brought about by least two mechanisms. First, immediate-type hypersensibility reactions due to IgE. Secondly, anaphylactic-type reactions due to interaction between transfused IgA and class specific anti IgA in the recipient's plasma. They are characterized by their severest form (anaphylactic shock). The frequency of severe reactions following the transfusion blood plasma is very low. These transfusion reactions are complement-mediated and kinins-mediated. Prevention of allergic reactions is necessary among blood donors and recipients.
authors.forename: E
authors.initials: E
authors.lastname: Hergon
authors.forename: M L
authors.initials: ML
authors.lastname: Paitre
authors.forename: B
authors.initials: B
authors.lastname: Coeffic
authors.forename: N
authors.initials: N
authors.lastname: Piard
authors.forename: J M
authors.initials: JM
authors.lastname: Bidet
mesh_terms: D000707:Anaphylaxis / Q000276:immunology* / Q000517:prevention & control; D001782:Blood Donors; D003165:Complement System Proteins / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology / Q000517:prevention & control*; D007070:Immunoglobulin A / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D007705:Kinins / Q000276:immunology; D065227:Transfusion Reaction
chemical_list: D007070:Immunoglobulin A; D007705:Kinins; D007073:Immunoglobulin E; D003165:Complement System Proteins
vernacular_title: Les accidents allergiques transfusionnels.