Effects of suprofen on renal function in patients with rheumatoid arthritis.
Suprofen is a new potent analgesic with antiinflammatory properties that appears to inhibit prostaglandin synthetase in a tissue-selective manner, having relatively little effect on the kidneys of experimental animals. The effects were studied of one week of treatment of rheumatoid arthritis patients with suprofen or ibuprofen on Na+ and K+ excretion, creatinine clearance, urinary enzymes that are markers for tubular damage, and urinary prostaglandins such as PGE2 and 6-keto PGF1 alpha (a stable metabolite of prostacyclin). Neither compound caused changes in renal function related to the week of treatment, but significant decreases in prostaglandins were observed: this change was fully reversible after discontinuation of the drug.
Malandrino
S
S
Angelini
M
M
Baldini
L
L
Barenghi
L
L
Borsa
M
M
Carrabba
M
M
Ceriotti
F
F
Tonon
G C
GC
D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000652:urine; D015237:Dinoprost; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010666:Phenylpropionates / Q000009:adverse effects*; D011460:Prostaglandins F / Q000652:urine; D011897:Random Allocation; D013496:Suprofen / Q000009:adverse effects* / Q000627:therapeutic use
D010666:Phenylpropionates; D011460:Prostaglandins F; D015121:6-Ketoprostaglandin F1 alpha; D013496:Suprofen; D015237:Dinoprost; D007052:Ibuprofen