The macrophage content of tumors is unrelated to levels of NK cell-mediated resistance.
Three malignant tumors (3LL carcinoma, mFS6 sarcoma, and B16 F1 melanoma) were transplanted in mice with congenital (beige) or acquired (anti-asialo GM1-treated) defects of natural killer cell (NK) activity. The macrophage content of the neoplastic tissues was not influenced by host NK activity levels. These data suggest that NK cell-mediated resistance does not play an appreciable role in the regulation of the levels of tumor-associated macrophages in established malignancy.
Polentarutti
N
N
Acero
R
R
Bottazzi
B
B
Taraboletti
G
G
Mantovani
A
A
D000818:Animals; D002277:Carcinoma / Q000276:immunology*; D002460:Cell Line; D006579:Heterozygote; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008545:Melanoma / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D012513:Sarcoma, Experimental / Q000276:immunology*; D013045:Species Specificity