title: New attachment formation in the human periodontium by guided tissue regeneration. Case reports.
abstract: The aim of the present study was to evaluate whether a regenerative surgical procedure, based on guided tissue regeneration, could predictably result in the formation of a new attachment in human teeth. The material included 12 teeth in 10 patients with advanced periodontal disease. Following flap elevation, scaling, root planing and removal of granulation tissue, a teflon membrane was placed over the denuded root surface in such a way that the epithelium and the gingival connective tissue were prevented from reaching contact with the root during healing. The flap was replaced on the outer surface of the membrane and secured with interdental sutures. This design of wound preparation gives preference to the cells originating from the periodontal ligament (PDL-cells) to repopulate the wound area adjacent to the root. Histologic analysis of the result of treatment was made in 5 of the 12 teeth scheduled for extraction. In the remaining 7 teeth, the result was evaluated using clinical measurements. The result of healing disclosed that in all teeth treated, substantial amounts of new attachment had formed. This suggests that predictable restitution of the attachment apparatus can be accomplished by using a method of treatment which is based on the principle of guided tissue regeneration.
authors.forename: J
authors.initials: J
authors.lastname: Gottlow
authors.forename: S
authors.initials: S
authors.lastname: Nyman
authors.forename: J
authors.initials: J
authors.lastname: Lindhe
authors.forename: T
authors.initials: T
authors.lastname: Karring
authors.forename: J
authors.initials: J
authors.lastname: Wennström
mesh_terms: D000328:Adult; D003238:Connective Tissue / Q000033:anatomy & histology / Q000502:physiology; D003739:Dental Cementum / Q000033:anatomy & histology / Q000502:physiology; D004846:Epithelial Attachment / Q000033:anatomy & histology / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008851:Micropore Filters; D008875:Middle Aged; D010510:Periodontal Diseases / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D010513:Periodontal Ligament / Q000033:anatomy & histology / Q000502:physiology*; D011138:Polytetrafluoroethylene; D012038:Regeneration; D014092:Tooth Root / Q000473:pathology / Q000503:physiopathology
chemical_list: D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene