Multiple cytogenetic abnormalities in a case of osteosarcoma.
Cytogenetic analysis of a highly malignant osteosarcoma in a 17-year-old girl revealed extremely complex karyotypic changes with several different clonal numerical and structural chromosome aberrations. The composite karyotype was interpreted as 39-41,X,t(X;9)(q11;p24), -1,der(1), -4, -4, -5,i(7q),-8,del(8)(q21),t(10;19)(p13;q13),del(11)(p11p13), t(12;18)(q24;q12), -13,13q+,-14,14p+,-15,15q+,17p+,19q+,-21,+22,+3-6 mar.
Mandahl
N
N
Heim
S
S
Kristoffersson
U
U
Mitelman
F
F
Rydholm
A
A
Rööser
B
B
Willén
H
H
D000293:Adolescent; D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D007866:Leg; D012516:Osteosarcoma / Q000235:genetics* / Q000473:pathology