Calmodulin in lymphocyte mitogenic stimulation and in lymphoid cell line growth.
Calmodulin levels are elevated three- to fourfold in the dividing cells, resulting from the lectin-induced stimulation of fresh human lymphocytes. This increase in calmodulin appears to be related mainly to progression into S phase and supports the hypothesis that calmodulin might be crucial in regulating the progression of lymphoblasts through their division cycle. Calmodulin levels are higher in a lymphoid cell line derived from human acute lymphoblastic leukemia blood cells than in a lymphoid cell line derived from normal human blood cells, suggesting that calmodulin could be an important mediator of the leukemogenetic process.
Rainteau
D
D
Sharif
A
A
Bourrillon
R
R
Weinman
S
S
D002147:Calmodulin / Q000097:blood*; D002455:Cell Division; D002460:Cell Line; D002478:Cells, Cultured; D004261:DNA Replication; D005434:Flow Cytometry; D006801:Humans; D007399:Interphase; D007700:Kinetics; D007945:Leukemia, Lymphoid; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*
D002147:Calmodulin