The activity of ofloxacin against methicillin-resistant Staphylococcus aureus.
The return of multiresistant Staphylococcus aureus strains and the appearance of methicillin-resistant strains resistant as well to rifampin and fusidic acid increase the need for new agents to treat infections caused by such strains. Ofloxacin susceptibility of 109 selected methicillin-resistant staphylococci (with MIC90 of 1,000 mg/l for methicillin, 1.3% being resistant to gentamicin with MICs ranging from 25 to 100 mg/l, chloramphenicol MICs ranging from 25 to 100 mg/l and resistant to beta-lactam-antibiotics and clindamycin), was determined by an agar dilution method. MICs of ofloxacin for methicillin-resistant staphylococci ranged from 0.09 to 0.78 mg/l, with an MIC90 of 0.39 mg/l. The in vitro results suggest a possible clinical role for ofloxacin in infections caused by methicillin-resistant staphylococci. However, further investigations are needed.
Mraović
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M
Canić-Radojlović
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M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D008712:Methicillin / Q000494:pharmacology; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology*; D010403:Penicillin Resistance; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D010078:Oxazines; D015242:Ofloxacin; D008712:Methicillin