Treatment of mycosis fungoides with isotretinoin.
A 56-year-old man with a 7-year history of well-documented mycosis fungoides is reported. Because the patient was a treatment failure with topical nitrogen mustard due to severe allergic contact dermatitis, and because of recent reports of the efficacy of retinoid compounds, he was treated with a 6-month course of isotretinoin with total clearing of his skin lesions. Previous case reports and possible mechanisms of action are reviewed.
Fitzpatrick
J E
JE
Mellette
J R
JR
D006801:Humans; D007109:Immunity / Q000187:drug effects; D015474:Isotretinoin; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D009588:Nitrogen Mustard Compounds / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D014212:Tretinoin / Q000627:therapeutic use*
D009588:Nitrogen Mustard Compounds; D014212:Tretinoin; D015474:Isotretinoin