A preliminary metabolic study of alpidem in rat and man.
The metabolism of alpidem, a new anxiolytic agent in the chemical series of imidazopyridines, was investigated in rat and man. In both species the compound is extensively metabolised by three main routes of biotransformation: aromatic oxidation of the imidazopyridine ring; n-dealkylation; and/or aliphatic oxidation of the substituted amide side chains.
Padovani
P
P
Laboratoire d'Etudes et de Recherches Synthélabo Paris, France.
Guinebault
P
P
Vajta
S
S
Durand
A
A
Allen
J
J
Thenot
J P
JP
Morselli
P L
PL
D000328:Adult; D000818:Animals; D001646:Bile / Q000032:analysis; D001711:Biotransformation / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000032:analysis / Q000378:metabolism* / Q000652:urine; D008297:Male; D011725:Pyridines / Q000032:analysis / Q000378:metabolism* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D007093:Imidazoles; D011725:Pyridines; C052036:alpidem