title: A linkage study of Emery-Dreifuss muscular dystrophy.
abstract: We have searched for linkage between polymorphic loci defined by DNA markers on the X chromosome and X-linked Emery-Dreifuss muscular dystrophy (EDMD). There are high recombination rates between EDMD and the Xp loci known to be linked to Becker and Duchenne muscular dystrophy. There is a suggestion of linkage between EDMD and the loci DXS52 and DXS15, defined by probes St14 and DX13 respectively, located at Xq28. Z for DXS15 = 1.14 at theta = 0.15. This is in agreement with the previously reported linkage between a disorder strongly resembling EDMD and colour-blindness (Thomas et al. 1972), suggesting that there is a second locus on the X chromosome concerned with muscle integrity.
authors.forename: S
authors.initials: S
authors.lastname: Hodgson
authors.forename: E
authors.initials: E
authors.lastname: Boswinkel
authors.forename: C
authors.initials: C
authors.lastname: Cole
authors.forename: A
authors.initials: A
authors.lastname: Walker
authors.forename: V
authors.initials: V
authors.lastname: Dubowitz
authors.forename: C
authors.initials: C
authors.lastname: Granata
authors.forename: L
authors.initials: L
authors.lastname: Merlini
authors.forename: M
authors.initials: M
authors.lastname: Bobrow
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009136:Muscular Dystrophies / Q000235:genetics*; D020389:Muscular Dystrophy, Emery-Dreifuss; D010375:Pedigree; D014960:X Chromosome
chemical_list: D005819:Genetic Markers