title: Chromosomal subclonal evolution in paroxysmal nocturnal hemoglobinuria evolving into acute megakaryoblastic leukemia.
abstract: Four cytogenetic studies were performed in the course of a paroxysmal nocturnal hemoglobinuria evolving into acute megakaryoblastic leukemia. The clonal evolution was characterized by a unique structural change (9p) at the time of diagnosis, heralding an accelerated and complex karyotypic alteration including 5q-, 12p-, +21, -5, -7. At the terminal phase, the initial population was replaced within 1 week by a new overgrowing clone with -5, +8, +17. This suggests that the paroxysmal nocturnal hemoglobinuria-associated preleukemia and leukemic states share with acute nonlymphocytic leukemia the same nonrandom chromosomal changes.
authors.forename: J R
authors.initials: JR
authors.lastname: Teyssier
authors.forename: F
authors.initials: F
authors.lastname: Pigeon
authors.forename: C
authors.initials: C
authors.lastname: Behar
authors.forename: B
authors.initials: B
authors.lastname: Pignon
authors.forename: A M
authors.initials: AM
authors.lastname: Blaise
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002999:Clone Cells; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D007947:Leukemia, Megakaryoblastic, Acute / Q000209:etiology / Q000235:genetics*; D011289:Preleukemia / Q000235:genetics; D013997:Time Factors