Effect of 1 alpha-hydroxyvitamin D3 on osteoporosis induced by immobilization combined with ovariectomy in rats.
The effect of low-dose 1 alpha-hydroxyvitamin D3 [1 alpha(OH)D3] on experimental osteoporosis in rats induced by a combination of hemicordotomy and ovariectomy was evaluated. 1 alpha(OH)D3 (0.1 microgram/kg 1 alpha(OH)D3 three times a week) increased the femur score and photo-density. The administration of 1 alpha(OH)D3 also significantly increased the dry weight and ash weight of the bone. Histomorphometry revealed a significant decrease of bone resorption by the administration of 1 alpha(OH)D3. Significant decreases in 45Ca accretion rate and 14C-proline uptake were also observed. Bone formation in the 1 alpha(OH)D3 treated group was thought to decrease following the decrease of bone resorption.
Okumura
H
H
Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Japan.
Yamamuro
T
T
Kasai
R
R
Hayashi
T
T
Tada
K
K
Nishii
Y
Y
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D002118:Calcium / Q000378:metabolism; D003720:Densitometry; D004195:Disease Models, Animal; D005260:Female; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D007103:Immobilization; D008852:Microradiography; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D010052:Ovariectomy / Q000009:adverse effects; D051381:Rats; D011919:Rats, Inbred Strains
D006887:Hydroxycholecalciferols; D002118:Calcium; C008088:alfacalcidol