title: Terminal deoxynucleotidyl transferase negative acute lymphoblastic leukemia in two offspring of mothers exposed to diethylstilbestrol (DES) in utero.
abstract: We report two children with leukemia who were born to diethylstilbestrol (DES)-exposed mothers. The children were 2 and 6 years old at diagnosis and the lymphoblasts expressed the unusual terminal deoxynucleotidyl transferase negative phenotype. Both children completed induction and maintenance therapy and are alive 6 and 4 years from diagnosis. The role of DES as a transplacental carcinogen is reviewed, and a hypothesis for the target cell interaction is proposed.
authors.forename: P M
authors.initials: PM
authors.lastname: Zeltzer
authors.forename: V A
authors.initials: VA
authors.lastname: Saldivar
mesh_terms: D004253:DNA Nucleotidylexotransferase / Q000378:metabolism*; D004254:DNA Nucleotidyltransferases / Q000378:metabolism*; D004054:Diethylstilbestrol; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000139:chemically induced* / Q000201:enzymology / Q000235:genetics
chemical_list: D004054:Diethylstilbestrol; D004254:DNA Nucleotidyltransferases; D004253:DNA Nucleotidylexotransferase