P300 and CT scan in patients with chronic schizophrenia.
Twenty chronic male schizophrenic subjects aged 30-50 years were examined by an auditory event-related potential procedure for the evaluation of the P300 component, a CT scan and a neuropsychological test battery. The P300 latency was increased and its amplitude was reduced. CT scan measures showed lateral and third ventricle enlargement, and there was a global neuropsychological impairment. Poor neuropsychological performances were consistently associated with delayed P300 latencies, but not with CT scan measures. Ventricular enlargement was more pronounced among subjects with a negative family history for major psychiatric disorders.
Romani
A
A
C. Mondino Institute, Neurological Clinic, Pavia, Italy.
Merello
S
S
Gozzoli
L
L
Zerbi
F
F
Grassi
M
M
Cosi
V
V
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D005072:Evoked Potentials, Auditory; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D014057:Tomography, X-Ray Computed