Localization of the human haptoglobin genes distal to the fragile site at 16q22 using in situ hybridization.
The distamycin A-sensitive fragile site fra(16)(q22) is a precisely localized chromosomal marker. When expressed at metaphase, it visibly separates the chromosome material on either side of the fragile site. Using a cDNA probe encoding both the alpha and beta haptoglobin chains, the haptoglobin loci were found by in situ hybridization to be distal to fra(16)(q22).
Simmers
R N
RN
Stupans
I
I
Sutherland
G R
GR
D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002874:Chromosome Mapping; D002902:Chromosomes, Human, 16-18; D004247:DNA / Q000235:genetics; D005819:Genetic Markers; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D009693:Nucleic Acid Hybridization
D005819:Genetic Markers; D006242:Haptoglobins; D004247:DNA