[Study on heterotransplantation of human malignant urogenital tumors in nude mice: establishment of the tumor line in nude mice from human primary ureteral tumor and its characteristics].
The tumor line in nude mice is one of the most important experimental animal models for oncodevelopmental studies. We implanted a human ureteral tumor into nude mice, established the tumor line, AM-UT-1, and maintained it by serial transplantation. The characteristics of this tumor line in nude mice are reported. Histologically, the original tumor was a transitional cell carcinoma (grade II, stage B). The transplanted tumor grew locally and had a constant growth pattern during serial passage until the 13th passage in nude recipients and maintained the basic histological, immunohistochemical findings of the original tumor. Both original tumor and serial transplanted tumor had carcinoembryonic antigen (CEA)-producing activity. A high level of serum CEA was also recognized in nude mice.
Fukatsu
H
H
Department of Urology, Aichi Medical University.
Yamada
H
H
Nonomura
H
H
Miyagawa
Y
Y
Hatano
Y
Y
Waki
M
M
Hiraiwa
S
S
Muramatsu
T
T
Yamada
Y
Y
Nishikawa
E
E
D000818:Animals; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000648:ultrastructure; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation; D014516:Ureteral Neoplasms / Q000473:pathology* / Q000648:ultrastructure
D002272:Carcinoembryonic Antigen