title: Long-term timolol and epinephrine in monkeys. I. Functional morphology of the ciliary processes.
abstract: Cynomolgus monkeys were treated twice daily in one eye with timolol 180 micrograms for 2.7, 6.0, or 7.4 months (2 monkeys for each period) or epinephrine 540-600 micrograms for 6.7 months (2 monkeys). Some ciliary processes in both eyes of all timolol-treated monkeys exhibited light and electron microscopic changes consistent with decreased secretion: narrowed stromal vessels with few fenestrations surrounded by a thickened fibre sheath; thickened PE basement membrane; few PE and NPE basolateral infoldings; flattened NPE with small mitochondria. Additionally, the NPE contained pigment granules and large phagolysosomes. The processes in both eyes of the epinephrine-treated monkeys exhibited one of two pictures: dilated stromal capillaries with numerous fenestrations; normal stroma, PE basement membrane and PE; numerous well-developed NPE basolateral infoldings and enlarged mitochondria; dilated stromal capillaries with ruptured fenestrations; ballooned protein-filled stroma; degenerated NPE. The first picture could be consistent with hypersecretion, the second with hyposecretion. Possible pathophysiological explanations and implications of these findings are discussed.
authors.forename: E
authors.initials: E
authors.lastname: Lütjen-Drecoll
authors.forename: P L
authors.initials: PL
authors.lastname: Kaufman
authors.forename: M
authors.initials: M
authors.lastname: Eichhorn
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001485:Basement Membrane / Q000648:ultrastructure; D002924:Ciliary Body / Q000187:drug effects* / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology*; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D008252:Macaca fascicularis; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D013999:Timolol / Q000494:pharmacology*
chemical_list: D013999:Timolol; D004837:Epinephrine