Acute myelomonocytic leukemia with double minute chromosomes and a normal karyotype.
A case of acute myelomonocytic leukemia in a 74-year-old male patient is described whose bone marrow cells had a normal male karyotype but with double minutes chromosomes (DM). The patient had no history of exposure to mutagenic or carcinogenic agents, or a history of other malignancies. The clinical and etiologic implications of DM as a sole karyotypic anomaly in the leukemic cells are discussed.
Ohyashiki
J H
JH
Ohyashiki
K
K
Miller
K B
KB
Cuiffo
B P
BP
Sandberg
A A
AA
D000368:Aged; D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002882:Chromosomes, Human, Pair 13; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male