[Postprandial delay of drug absorption in a gitoformate model].
Oral absorption of gitoformate (Dynocard), a non-renal-dependent cardiac glycoside, was investigated in 8 healthy subjects aged 23-45 years. Plasma concentration-time profiles were obtained once following a 12-h period of fasting, then after intake of a standard high protein meal. The half-life of absorption t1/2a, Cmax and tmax, half-life of elimination t1/2z, and area under the curve (AUC) were compared to evaluate the influence on the bioavailability of gitoformate. t1/2a in the fasting condition (0.36 +/- 0.43 h) is increased when gitoformate is applied after a high protein meal 1.12 +/- 1.12 h). Correspondingly, fasting maximum concentrations are already achieved after 1.4 +/- 1.2 h, but only after 4.8 +/- 1.8 h following the intake of a standard meal. Comparison of AUC (0-168 h) showed that the bioavailability was reduced by 25% after meals.
Kubin
S
S
Abteilung für Klinische Pharmakologie, Johann Wolfgang Goethe-Universität, Frankfurt/Main.
Woodcock
B G
BG
Menke
G
G
Rietbrock
N
N
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D004077:Digoxin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005215:Fasting; D005260:Female; D005502:Food; D006207:Half-Life; D006801:Humans; D007536:Isomerism; D008297:Male
D004077:Digoxin; C008785:pentaformylgitoxin
Postprandiale Resorptionsverzögerung von Pharmaka am Modell des Gitoformat.