title: [No indications for the mutagenicity of ofloxacin].
abstract: The antibacterial activity of ofloxacin, as demonstrated in the Rec assay, showed a harmful effect on the DNA of Bacteroides subtilis. In contrast, there was no significant harmful effect on the DNA of eukaryonts. Ofloxacin did not cause any point mutations, nor did it induce any in vivo or in vitro chromosome mutation in the systems tested. These tests lead us to the conclusion that there are no indications of ofloxacin having any mutagenic effects.
authors.forename: D
authors.initials: D
authors.lastname: Mayer
authors.forename: K
authors.initials: K
authors.lastname: Bruch
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D002460:Cell Line; D002869:Chromosome Aberrations; D006224:Cricetinae; D004260:DNA Repair / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009154:Mutation; D015242:Ofloxacin; D010078:Oxazines / Q000633:toxicity*; D011247:Pregnancy; D012854:Sister Chromatid Exchange / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin
vernacular_title: Kein Hinweis für Mutagenität von Ofloxacin.