title: [Multicenter study of the activity of pefloxacin on bacteria isolated in a hospital milieu].
abstract: Minimal inhibitory concentrations (MICs) of pefloxacin were evaluated by agar dilution for 3422 bacterial strains isolated in nine hospitals. Enterobacteriaceae proved very sensitive to pefloxacin: 62 p. 100 of 1743 strains tested had MIC less than or equal to 0.12 and 90 p. 100 less than or equal to 1 microgram/ml; but the percent of strains with MIC greater than or equal to 2 varied among the different groups of Enterobacteriaceae: 2.7 p. 100 for E. coli to 39 p. 100 for Serratia. 55 p. 100 for Pseudomonas and 81 p. 100 of Acinetobacter were inhibited by 1 micrograms/ml or less (mode MIC 1 and 0.5 micrograms/ml). Haemophilus sp.: 0.03 and 0.06 micrograms/ml and Gonococci were very sensitive to pefloxacin. The spectrum of pefloxacin extended to Gram positive cocci: MIC of Staphylococci were 0.06 to 8 micrograms/ml (mode MIC: 0.5); Enterococci, other Streptococci and Pneumococci were less sensitive: 2 and 4 micrograms/ml for the majority of strains. Concerning anaerobic bacteria, pefloxacin was more active against Clostridium (0.5 to 1 microgram/ml generally), than against Bacteroides (4 to 16 micrograms/ml).
authors.forename: C J
authors.initials: CJ
authors.lastname: Soussy
authors.forename: J F
authors.initials: JF
authors.lastname: Acar
authors.forename: E
authors.initials: E
authors.lastname: Bergogne-Berezin
authors.forename: D
authors.initials: D
authors.lastname: Christol
authors.forename: A L
authors.initials: AL
authors.lastname: Courtieu
authors.forename: J
authors.initials: J
authors.lastname: Duval
authors.forename: J
authors.initials: J
authors.lastname: Fleurette
authors.forename: M B
authors.initials: MB
authors.lastname: Lareng
authors.forename: C
authors.initials: C
authors.lastname: Morel
authors.forename: A
authors.initials: A
authors.lastname: Thabaut
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D006761:Hospitals; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D015366:Pefloxacin
chemical_list: D015366:Pefloxacin; D009643:Norfloxacin
vernacular_title: Etude multicentrique de l'activité de la péfloxacine sur les bactéries isolées en milieu hospitalier.