Chlorproguanil and chlorcycloguanil concentrations in human plasma and urine after Lapudrine administration.
Chlorproguanil and chlorcycloguanil concentrations in human plasma and urine were measured using a high performance liquid chromatographic method. The detection limit in plasma and urine was 5 ng/ml for chlorproguanil and 10 ng/ml for chlorcycloguanil. The elimination half-life of chlorproguanil (Lapudrine) in 2 healthy volunteers, after a single oral dose of the drug, was 14.7 and 16.1 h. No chlorcycloguanil could be detected in plasma over 32 h after dosing.
Edstein
M D
MD
Army Malaria Research Unit, Military Post Office, Ingleburn, NSW, Australia.
Veenendaal
J R
JR
D000328:Adult; D000962:Antimalarials / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D006801:Humans; D008297:Male; D002727:Proguanil / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D014227:Triazines
D000962:Antimalarials; D014227:Triazines; C026009:cycloguanil; C007030:chlorproguanil; D002727:Proguanil