title: Increased frequency of DR2 in patients with aplastic anaemia and increased DR sharing in their parents.
abstract: 68 patients with aplastic anaemia, their parents and healthy siblings were typed for HLA-A, B and DR antigens. Among the patients there is an overrepresentation of DR2. The parents of affected children show an increased compatibility at the DR locus. This situation could favour the expression of recessive gene(s) involved in haematopoiesis and located in the HLA locus.
authors.forename: B
authors.initials: B
authors.lastname: Chapuis
authors.forename: V E
authors.initials: VE
authors.lastname: Von Fliedner
authors.forename: M
authors.initials: M
authors.lastname: Jeannet
authors.forename: H
authors.initials: H
authors.lastname: Merica
authors.forename: P
authors.initials: P
authors.lastname: Vuagnat
authors.forename: A
authors.initials: A
authors.lastname: Gratwohl
authors.forename: C
authors.initials: C
authors.lastname: Nissen
authors.forename: B
authors.initials: B
authors.lastname: Speck
mesh_terms: D000483:Alleles; D000741:Anemia, Aplastic / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis* / Q000235:genetics; D006801:Humans; D010290:Parents
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II