title: Evidence following splenic radiotherapy for a highly dynamic traffic of CFU-GM between the spleen and other organs in chronic granulocytic leukaemia.
abstract: Five patients with Ph1 +ve chronic granulocytic leukaemia and massive splenomegaly were given induction therapy with splenic irradiation, and their peripheral blood leucocyte count and granulocyte macrophage progenitor (CFU-GM) concentration monitored during the following six hours. In each patient there was a greater fall in CFU-GM than would have been expected from the fall in leucocyte count, but no evidence of a plasma inhibitor was found to explain the disproportionate reduction in CFU-GM. The difference between the estimated and observed decrease in CFU-GM/1 following splenic irradiation indicates a highly dynamic traffic of CFU-GM from the spleen to other organs in chronic granulocytic leukaemia.
authors.forename: T C
authors.initials: TC
authors.lastname: Morris
authors.forename: P C
authors.initials: PC
authors.lastname: Vincent
authors.forename: F W
authors.initials: FW
authors.lastname: Gunz
authors.forename: R
authors.initials: R
authors.lastname: Sutherland
authors.forename: R
authors.initials: R
authors.lastname: Zbroja
authors.forename: A E
authors.initials: AE
authors.lastname: Irvine
authors.forename: P R
authors.initials: PR
authors.lastname: Forrest
mesh_terms: D000328:Adult; D002453:Cell Cycle / Q000528:radiation effects; D002465:Cell Movement; D003114:Colony-Forming Units Assay; D006098:Granulocytes / Q000166:cytology*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology / Q000532:radiotherapy*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000473:pathology* / Q000528:radiation effects