title: Microbial transformation of azacarbazoles. IX. Preliminary studies on hydroxylation of 2,3-benzo-1,4-dimethyl-alpha-iso-carboline by Paecilomyces flavinosus.
abstract: Microbial transformation of 2,3-benzo-1,4-dimethyl-alpha-iso-carboline performed with several strains of fungi Beauveria bassiana, Verticillum lecani and Paecilomyces flavinosus yielded common products which were expected to be hydroxylated derivatives of starting compound. Among the microorganisms tested, strain Paecilomyces flavinosus P-5 was selected to perform quantitative bioconversion of 2,3-benzo-1,4-dimethyl-alpha-iso-carboline for preparative scale.
authors.affiliation: Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
authors.forename: W
authors.initials: W
authors.lastname: Peczyńska-Czoch
authors.forename: M
authors.initials: M
authors.lastname: Mordarski
authors.forename: L
authors.initials: L
authors.lastname: Kaczmarek
authors.forename: P
authors.initials: P
authors.lastname: Nantka-Namirski
mesh_terms: D001711:Biotransformation; D002243:Carbolines / Q000302:isolation & purification / Q000493:pharmacokinetics*; D006900:Hydroxylation; D003904:Mitosporic Fungi / Q000378:metabolism*; D010143:Paecilomyces / Q000378:metabolism*
chemical_list: D002243:Carbolines; C055575:5,11-dimethyl-5H-indolo(2,3-b)quinoline