[Effect of trihydroxyoctadecadienoic acids on the blood content of prostaglandins E2 and F2 alpha and 5-hydroxyeicosatetraenoic acid in rats with alloxan diabetes].
It has been demonstrated that the level of prostaglandin F2 alpha and 5-hydroxyeicosatetraenoic acid (5-HETE) in the serum of alloxan-diabetic rats is reduced by 85% and 25%, respectively, whereas that of prostaglandin E2 is increased by 34%. The administration of trihydroxyoctadecadienoic acids, that have a hypoglycemic effect, to diabetic animals brings about a rise in the level of prostaglandins F2 alpha, E2 and 5-HETE by 33%, 64% and 279%, respectively, as compared to the control.
Vartanian
G S
GS
Panosian
A G
AG
Karagezian
K G
KG
Gevorkian
G A
GA
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D015237:Dinoprost; D015232:Dinoprostone; D004353:Drug Evaluation, Preclinical; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D006880:Hydroxy Acids / Q000627:therapeutic use*; D006893:Hydroxyeicosatetraenoic Acids / Q000097:blood*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D011458:Prostaglandins E / Q000097:blood*; D011460:Prostaglandins F / Q000097:blood*; D051381:Rats
D005231:Fatty Acids, Unsaturated; D006880:Hydroxy Acids; D006893:Hydroxyeicosatetraenoic Acids; D007004:Hypoglycemic Agents; D011458:Prostaglandins E; D011460:Prostaglandins F; C022022:5-hydroxy-6,8,11,14-eicosatetraenoic acid; D015237:Dinoprost; D015232:Dinoprostone
Vliianie trigidroksioktadekadienovykh kislot na soderzhanie prostaglandinov E2, F2 al'fa i 5-gidroksiéĭkozatetraenovoĭ kisloty v krovi krys pri alloksanovom diabete.