Heteromorphism of C-band positive chromosomal regions in CML patients.
The heteromorphism of constitutive heterochromatin in chromosomes #1, #9, and #16 was investigated in 44 chronic myelocytic leukemia patients and 44 controls using bone marrow and peripheral blood lymphocyte cultures. A significant increase in the length of C-band region in all the three chromosome pairs as well as a statistically significant difference in the homologs of chromosome #1 was observed in chronic myelocytic leukemia patients when compared with the controls. The frequency of inversions was also greater in the patients than in the controls. A random translocation of 22q was found on either homolog of chromosome #9.
Adhvaryu
S G
SG
Dave
B J
BJ
Trivedi
A H
AH
Jani
K H
KH
Vyas
R C
RC
D002871:Chromosome Banding; D007446:Chromosome Inversion; D005819:Genetic Markers; D006570:Heterochromatin / Q000235:genetics* / Q000648:ultrastructure; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D011110:Polymorphism, Genetic
D005819:Genetic Markers; D006570:Heterochromatin