Pharmacokinetics of sulphobromophthalein, lidocaine and indocyanine green in the course of subclinical fascioliasis in sheep.
The pharmacokinetics of three drugs proposed for the assessment of liver function: sulphobromophthalein (BSP), lidocaine and indocyanine green (ICG) were determined in sheep four, eight, 12, 16 and 24 weeks after their infestation by an oral administration of 150 metacercariae of Fasciola hepatica. The disposition of BSP was altered by a significant decrease in its total plasma clearance from eight weeks after infection onwards. This change could be related to the low values of the elimination rate constant consistent with a reduced liver cytosolic conjugation of the dye to glutathione. Lidocaine pharmacokinetics were unaffected by parasitism and the only effect on ICG was an increased volume of distribution consistent with the liver hypertrophy caused by the subclinical fascioliasis.
Tufenkji
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AE
Station de Pharmacologie-Toxicologie, INRA, Toulouse, France.
Alvinerie
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M
Houin
G
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Galtier
P
P
D000818:Animals; D005210:Fasciola hepatica; D005211:Fascioliasis / Q000378:metabolism / Q000662:veterinary*; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D008012:Lidocaine / Q000493:pharmacokinetics*; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000378:metabolism* / Q000469:parasitology; D013448:Sulfobromophthalein / Q000493:pharmacokinetics*
D013448:Sulfobromophthalein; D008012:Lidocaine; D007208:Indocyanine Green