Complexity of an apparently simple variant Ph translocation in chronic myeloid leukemia.
A patient with chronic myeloid leukemia (CML) presented with an apparently simple Ph translocation t(19;22)(q13;q11). In-situ hybridization revealed movement of the c-abl oncogene from a cytogenetically normal chromosome 9 to the Ph. Bcr-3' and c-sis probes hybridized to distal 1p and not to the 19q+ chromosome as expected from the cytogenetic findings. We concluded that this patient had a complex translocation involving four chromosomes: t(1;9;19;22)(p36;q34;q13;q11).
Morris
C M
CM
Fitzgerald
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PH
D000328:Adult; D002871:Chromosome Banding; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D009693:Nucleic Acid Hybridization; D010677:Philadelphia Chromosome