A reduction of central peptidergic responses in the spontaneously hypertensive rat.
The effect of intraventricular perfusion with hypertonic saline (HS) or angiotensin II (ANG II) on cerebrospinal fluid (CSF) vasopressin (AVP), blood pressure and heart rate was determined in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. There was a marked reduction in the central peptidergic response in the SHR. Pretreatment with the AVP (V1) antagonist abolished the pressor response to intraventricular HS in the WKY rats, but not in the SHR.
Morris
M
M
Sain
L E
LE
Schumacher
S J
SJ
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001127:Arginine Vasopressin / Q000134:cerebrospinal fluid; D001794:Blood Pressure; D001921:Brain / Q000378:metabolism*; D006339:Heart Rate; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism*; D011919:Rats, Inbred Strains / Q000378:metabolism*; D012462:Saline Solution, Hypertonic
D012462:Saline Solution, Hypertonic; D000804:Angiotensin II; D001127:Arginine Vasopressin