title: Marker ring chromosome--a new cytogenetic abnormality characterizing lipogenic tumors?
abstract: We have analyzed three intramuscular lipomas, two atypical and one with ordinary benign histology, as part of a systematic study of the karyotypic characteristics of mesenchymal tumors. A large ring chromosome of uncertain origin, but possibly representing a rearranged chromosome #3, was found in all three tumors. Previous reports on the chromosome banding pattern in lipogenic neoplasms are restricted to only three cases, all liposarcomas. In one of these, a well differentiated liposarcoma, a ring chromosome was described that was remarkably similar in morphology to the aberration reported here. We conclude that this ring chromosome may constitute a characteristic cytogenetic marker for lipogenic tumors.
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: U
authors.initials: U
authors.lastname: Kristoffersson
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
authors.forename: B
authors.initials: B
authors.lastname: Rööser
authors.forename: A
authors.initials: A
authors.lastname: Rydholm
authors.forename: H
authors.initials: H
authors.lastname: Willén
mesh_terms: D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002893:Chromosomes, Human, Pair 3; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008067:Lipoma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012303:Ring Chromosomes; D013848:Thigh
chemical_list: D005819:Genetic Markers