[Effect of disulfiram on the interconnected activity of cortical neurons in trained cats].
The action of disulfiram on interconnected activity of neurones in the visual and motor cortical areas was studied in cats with food-procuring conditioned responses to light. Multiunit activity was recorded from the areas and, by means of amplitude discrimination, separated into impulse flows. Crosscorrelation analysis of the impulse series was used to reveal the character and temporal parameters of interconnected activities of neurones firing in correlation within the limits both of the same cortical area and of the two different ones. A depressing action was shown of the disulfiram on the food-procuring reaction, accompanied by a decrease of the number of pairs of neurones from the visual and motor cortical areas mostly acting in interconnection, interactions with long time delays being mostly affected. The character of action of neighbouring neurones in the visual and motor cortical areas changed in the same direction, expressed in their firing by a "common source" type. The question is discussed of disulfiram influence on interneuronal connections of both types suggesting a decrease of alimentary motivation as well as disturbance of food-procuring conditioned motor coordination.
Merzhanova
G Kh
GKh
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002415:Cats; D003214:Conditioning, Classical / Q000187:drug effects* / Q000502:physiology; D003864:Depression, Chemical; D004221:Disulfiram / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D007395:Interneurons / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009042:Motivation / Q000187:drug effects / Q000502:physiology; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D010880:Piperidines / Q000494:pharmacology; D013237:Stereoisomerism; D013997:Time Factors; D014793:Visual Cortex / Q000187:drug effects* / Q000502:physiology
D010880:Piperidines; C026539:preclamol; D004221:Disulfiram
Vliianie disul'firama na vzaimosviazannuiu deiatel'nost' korkovykh neĭronov u obuchennykh koshek.