Prostaglandin release following Nd:YAG iridotomy in rabbits.
In this study, iridotomies were performed in nine rabbit eyes using an Nd:YAG laser at 5.2 mJ, three pulses/burst, for one burst. Prostaglandin E2 (PGE2) in aqueous humor obtained at timed intervals after treatment was then measured using a sensitive and specific radioimmunoassay. Concentrations of PGE2 (mean +/- SD pg/ml) were: pretreatment, 377 +/- 89; 30 minutes, 1858 +/- 241; 120 minutes, 735 +/- 308; and 240 minutes, 401 +/- 59, postoperatively. The release of PGE2 into the aqueous humor parallels the rise in intraocular pressure following Nd:YAG iridotomies in rabbits and thus may contribute to this phenomenon.
Gailitis
R
R
Peyman
G A
GA
Pulido
J
J
Mitchell
M D
MD
Weinreb
R M
RM
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D015232:Dinoprostone; D007498:Iris / Q000601:surgery*; D053685:Laser Therapy; D008297:Male; D011184:Postoperative Period; D011458:Prostaglandins E / Q000378:metabolism*; D011817:Rabbits; D011863:Radioimmunoassay
D011458:Prostaglandins E; D015232:Dinoprostone