title: Inversion of chromosome 3 in a case of chronic myelogenous leukemia with abnormal thrombopoiesis.
abstract: A patient with chronic myelogenous leukemia (CML) associated with a remarkable increase of micromegakaryocytes in bone marrow was revealed to have an abnormality of a long arm of chromosome #3, i.e., inv(3)(q21q26), in addition to a complex Ph translocation: t(9;22;15)(q34;q11;q22). Although several cases of acute leukemia with inv(3)(q21q26) and abnormal megakaryocytes have been reported, this is the first case in which the association of inv(3)(q21q26) with a megakaryocytic abnormality was observed in a patient with CML. Our findings suggest that this structural rearrangement may be more specifically associated with abnormal thrombopoiesis than are other structural anomalies of 3q.
authors.forename: C
authors.initials: C
authors.lastname: Shimazaki
authors.forename: N
authors.initials: N
authors.lastname: Fujita
authors.forename: S
authors.initials: S
authors.lastname: Nakanishi
authors.forename: A
authors.initials: A
authors.lastname: Nishio
authors.forename: H
authors.initials: H
authors.lastname: Haruyama
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.forename: H
authors.initials: H
authors.lastname: Ijichi
authors.forename: K
authors.initials: K
authors.lastname: Nishida
authors.forename: S
authors.initials: S
authors.lastname: Misawa
mesh_terms: D001792:Blood Platelets; D007446:Chromosome Inversion; D002900:Chromosomes, Human, 1-3; D006410:Hematopoiesis; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000235:genetics*; D008297:Male; D008533:Megakaryocytes / Q000473:pathology; D008875:Middle Aged; D010677:Philadelphia Chromosome; D010976:Platelet Count