Low levels and lack of function of muscarinic binding sites in human skin fibroblasts from five affectively ill patients and two control subjects.
Skin fibroblasts of five subjects with affective illness and two control subjects were examined for muscarinic receptors. Contrary to recent findings, there were low levels of muscarinic binding sites and no evidence that these sites mediate a biological response.
Lin
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Richelson
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D001714:Bipolar Disorder / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D002460:Cell Line; D003866:Depressive Disorder / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D005347:Fibroblasts / Q000032:analysis / Q000378:metabolism; D005819:Genetic Markers; D006801:Humans; D011618:Psychotic Disorders / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D011976:Receptors, Muscarinic / Q000032:analysis / Q000378:metabolism* / Q000502:physiology; D012867:Skin / Q000032:analysis / Q000378:metabolism
D005819:Genetic Markers; D011976:Receptors, Muscarinic