title: [Complications induced by general anesthetics].
abstract: We reported 38 observations with adverse reactions during anesthesia. These observations have collected over about one year. For each observation we studied some parameters like sex, aspect of the adverse reaction, number of general anesthesia before the accident, atopy, age etc. Among the parameters, we noticed the great frequency of reaction in the female group (81.5%) and an increased level of total IgE (greater than or equal to 150 Ul/ml) in 38%. For each investigated drug we realized skin test (Prick-test and when negative, intra-dermal test) and Lymphoblastic Transformation Test L.T.T.). The examinations are compared each other for a best diagnosis: when skin test (ST) and L.T.T. are together positive the allergic reaction is likely. when ST and L.T.T. are together negative, it is likely there is not allergic reactions with this drug. when there is a discordance between ST and L.T.T. prudently we recommend to avoid this drug for future anesthesia. Results of ST and L.T.T. are detailed for the 3 drugs which are more often investigated. That is to say: Thiopental, Suxamethonium, Fentanyl.
authors.affiliation: Laboratoire d'Immuno-Allergologie, C.H.R., Angers.
authors.forename: M
authors.initials: M
authors.lastname: Drouet
authors.forename: A
authors.initials: A
authors.lastname: Sabbah
authors.forename: J
authors.initials: J
authors.lastname: Le Sellin
authors.forename: J C
authors.initials: JC
authors.lastname: Bonneau
mesh_terms: D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005283:Fentanyl / Q000009:adverse effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced / Q000175:diagnosis; D012882:Skin Tests; D013390:Succinylcholine / Q000009:adverse effects; D013874:Thiopental / Q000009:adverse effects
chemical_list: D013390:Succinylcholine; D013874:Thiopental; D005283:Fentanyl
vernacular_title: Accidents dûs aux anesthésiques généraux.