RCH-ACV: a lymphoblastic leukemia cell line with chromosome translocation 1;19 and trisomy 8.
A cell line (RCH-ACV) was established from a bone marrow sample of a child with acute lymphoblastic leukemia (ALL). The cell line lacked Epstein-Barr virus nuclear antigen and exhibited a recently described nonrandom chromosome translocation, 1;19, thought to be associated with pre-B-ALL and poor prognosis. Banding studies confirm that the breakpoint of chromosome #19 occurs at p13.3. Cell surface marker analysis using a panel of monoclonal antibodies revealed markers consistent with common ALL phenotype. Although the cells did not show cytoplasmic immunoglobulin, studies of the immunoglobulin gene rearrangement confirmed the pre-B phenotype. This cell line could be of great value to studies of the role of the specific translocation 1;19 in the etiology of pre-B-ALL.
Jack
I
I
Seshadri
R
R
Garson
M
M
Michael
P
P
Callen
D
D
Zola
H
H
Morley
A
A
D002460:Cell Line; D002648:Child; D002900:Chromosomes, Human, 1-3; D002903:Chromosomes, Human, 19-20; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D014178:Translocation, Genetic; D014314:Trisomy
D007136:Immunoglobulins