Sulfites and skin pathology in children.
We report the case of 8 children (whose ages ranged between 2 and 7) who consulted us because of urticaria, accompanied by angioedema in 5 of the cases. An additives study was performed based on a habitual program. Sodium bisulfite hypersensitivity was detected with oral provocation test with doses of 5 and 25 mgs. The tests were positive within the first hour of observation in 2 cases, in the rest the reaction appeared later after the administration of the second dose; the reaction in 2 of the cases were semi-delayed. No respiratory symptomatology was detected in these patients.
Botey
J
J
Servicio de Alergia e Inmunologia Clinica, Hospital Infantil Valle de Hebron, Universidad Autonoma de Barcelona, Spain.
Cozzo
M
M
Eseverri
J L
JL
Marín
A
A
D000799:Angioedema / Q000139:chemically induced*; D000975:Antioxidants / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D005512:Food Hypersensitivity / Q000209:etiology; D005520:Food Preservatives / Q000009:adverse effects; D006801:Humans; D008297:Male; D013447:Sulfites / Q000009:adverse effects*; D014581:Urticaria / Q000139:chemically induced*
D000975:Antioxidants; D005520:Food Preservatives; D013447:Sulfites; C009279:sodium bisulfite