Synthesis of coenzyme A ester of retinoic acid: intermediate in vitamin A metabolism.
Coenzyme A esters of all-trans- and 13-cis-retinoic acid were synthesized for use in studying vitamin A metabolism. The esters were obtained by two different synthetic methods starting from retinoic acids, which were converted to activated succinimidyl esters or anhydrides. These in turn were coupled with coenzyme A to form their respective thioesters. The retinoyl coenzyme A esters were purified by reverse-phase high performance liquid chromatography.
Kutner
A
A
Renstrom
B
B
Schnoes
H K
HK
DeLuca
H F
HF
D003065:Coenzyme A / Q000138:chemical synthesis*; D004952:Esters / Q000138:chemical synthesis; D014212:Tretinoin; D014801:Vitamin A / Q000378:metabolism*
D004952:Esters; D014801:Vitamin A; D014212:Tretinoin; D003065:Coenzyme A