title: Cytogenetic studies of human brain tumors and their clinical significance. II. Meningioma.
abstract: Cytogenetic study of 45 meningiomas from 31 female and 14 male patients are reported. No chromosomal abnormalities were found in nine (20%). These were predominantly meningotheliomatous, and were from younger patients (average age, 46 years). Monosomy 22 was noted in only 20% and in 12 patients (27%) with other losses and rearrangements. Among the latter, 50% were either recurrent or recurrent and invasive, the majority were fibromatous and occurred in older patients. Nonrandom loss was observed of the Y and abnormalities of chromosomes #1, #7, and #14 and, to a lesser extent, chromosomes #18, #19, and #20. Meningiomas may begin with no chromosomal abnormalities, having meningotheliomatous histopathologic appearance, occur in younger patients, and are less aggressive. Karyotypic evolution following loss of a chromosome #22 continues with losses and rearrangements of other chromosomes with apparent nonrandom involvement of chromosomes #1, #7, #14 and Y. This karyotypic change is associated with aggressive tumor behavior and fibromatous morphology.
authors.forename: A
authors.initials: A
authors.lastname: Al Saadi
authors.forename: F
authors.initials: F
authors.lastname: Latimer
authors.forename: M
authors.initials: M
authors.lastname: Madercic
authors.forename: T
authors.initials: T
authors.lastname: Robbins
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality; D002869:Chromosome Aberrations; D002892:Chromosomes, Human, Pair 22; D002897:Chromosomes, Human, Pair 7; D005260:Female; D005819:Genetic Markers; D005910:Glioma / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000401:mortality; D008579:Meningioma / Q000235:genetics* / Q000401:mortality; D008875:Middle Aged; D009006:Monosomy; D014998:Y Chromosome
chemical_list: D005819:Genetic Markers