title: Theoretical aspects of carbon adsorbent applications for detoxification.
abstract: The paradox of "small volume" hemocarboperfusion is discussed, it is shown in the model experiments with human serum albumin solution that granular and fibrous activated carbons are the complement of one another with respect to the sorption of substances weakly and strongly bound to protein. Binary adsorbents synthesized extempore and based on carbon matrices and biospecific ligands are described. The concepts of "artificial digestion" and "artificial scab" are introduced.
authors.affiliation: Kavetsky Institute for Oncology Problems, Academy of Sciences, Ukrainian SSR, Kiev.
authors.forename: V G
authors.initials: VG
authors.lastname: Nikolaev
authors.forename: K E
authors.initials: KE
authors.lastname: Makhorin
authors.forename: V P
authors.initials: VP
authors.lastname: Sergeev
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D001187:Artificial Organs; D002244:Carbon / Q000008:administration & dosage; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D011485:Protein Binding; D012709:Serum Albumin / Q000302:isolation & purification; D014118:Toxins, Biological / Q000302:isolation & purification*
chemical_list: D012709:Serum Albumin; D014118:Toxins, Biological; D002244:Carbon