Effects of concanavalin A on 67Ga binding by tumor cells.
The in vitro uptakes of 67Ga-citrate and 45Ca-chloride in the presence of concanavalin A have shown that at low concentrations (10-50 micrograms/ml) 67Ga presents a significant increase not observed for 45Ca. At higher concentrations there is a sharp augmentation of both 67Ga and 45Ca incorporations. The augmentation of Trypan blue inclusion is a concomitant phenomenon at any concanavalin A concentration that indicates tumor cell plasma membrane changes in direct relationship with 67Ga uptake increase.
Anghileri
L J
LJ
Crone-Escanye
M C
MC
Robert
J
J
D000818:Animals; D002122:Calcium Chloride / Q000378:metabolism*; D002132:Calcium Radioisotopes / Q000378:metabolism*; D003208:Concanavalin A / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005710:Gallium Radioisotopes / Q000378:metabolism*; D009368:Neoplasm Transplantation; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000000981:diagnostic imaging*
D002132:Calcium Radioisotopes; D005710:Gallium Radioisotopes; D003208:Concanavalin A; D002122:Calcium Chloride