Serum fructosamine as a screening method for diabetes mellitus in patients with suspected acute myocardial infarction.
It is important to identify diabetic patients in a coronary care population because they have a higher risk of suffering congestive heart failure, dysrhythmias and death following myocardial infarction. In order to determine the most efficient screening method for diabetes, we compared fructosamine and glucose measurements on admission blood specimens from 256 consecutive patients. Of 15 (5.9%) known diabetic patients, 12 had glucose results greater than or equal to 7.8 mmol/l and nine had fructosamine levels greater than 2.87 mmol/l. However, elevated glucose results were also found in a high proportion (49.2%) of patients with no previous history of diabetes. We performed glucose tolerance tests in 107 patients after discharge to determine the frequency of false-positive observations. Fructosamine yielded five (4.6%) false-positive results, whereas plasma glucose yielded 47 (43.9%) false-positive observations. We conclude that serum fructosamine provides a more specific screening method for diabetes in this population because the results are unaffected by stress hyperglycemia.
Kyle
C
C
Department of Clinical Biochemistry, Green Lane Hospital, Auckland, NZ.
Baker
J
J
Metcalf
P
P
Johnson
R
R
Norris
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis; D003325:Coronary Care Units; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000175:diagnosis*; D005189:False Positive Reactions; D005260:Female; D019270:Fructosamine; D006595:Hexosamines / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000628:therapy; D011897:Random Allocation; D013312:Stress, Physiological / Q000097:blood
D001786:Blood Glucose; D006595:Hexosamines; D019270:Fructosamine