Microbial transformation of azacarbazoles. VIII. Production of 14C-labelled benzo-alpha-iso-carbolines by permeabilized cells of Kitasatosporia setae strain.
N-1 methylation of benzo-alpha-carbolines performed with Kitasatosporia setae strain yields corresponding benzo-alpha-iso-carbolines, compounds demonstrating relatively strong cytostatic and antitumor properties. To obtain radioactive benzo-alpha-iso-carbolines required for the further studies of their mode of antitumor action, a simple and useful method of the preparation of 14C-labelled compounds by microbial means has been elaborated.
Peczyńska-Czoch
W
W
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
D000192:Actinomycetales / Q000378:metabolism*; D001711:Biotransformation; D002243:Carbolines / Q000493:pharmacokinetics*; D002463:Cell Membrane Permeability; D004121:Dimethyl Sulfoxide; D008745:Methylation
D002243:Carbolines; D004121:Dimethyl Sulfoxide