title: Olivopontocerebellar atrophy: immunocytochemical and Golgi observations.
abstract: Brain tissue was obtained promptly after death from a patient with autosomal dominant olivopontocerebellar atrophy and studied by immunocytochemistry and a Golgi technique. Antiglutamic acid decarboxylase showed severe loss of Purkinje cells and their terminals in the dentate nucleus. Stains for neuron-specific enolase (NSE) and microtubule-associated proteins (MAP) confirmed the integrity of the dentate nucleus. Basket and stellate cells revealed secondary changes, but Golgi neurons were intact. Methods for NSE and MAP disclosed dendritic alterations and loss of neurons in the basis pontis and inferior olivary nuclei. Golgi impregnation of Purkinje cells showed loss of major dendrites, paucity of spiny branchlets, and axonal expansions.
authors.forename: A H
authors.initials: AH
authors.lastname: Koeppen
authors.forename: E J
authors.initials: EJ
authors.lastname: Mitzen
authors.forename: M B
authors.initials: MB
authors.lastname: Hans
authors.forename: K D
authors.initials: KD
authors.lastname: Barron
mesh_terms: D000368:Aged; D002531:Cerebellum / Q000648:ultrastructure; D002540:Cerebral Cortex / Q000473:pathology / Q000648:ultrastructure; D005968:Glutamate Decarboxylase; D006801:Humans; D007120:Immunochemistry; D008297:Male; D008869:Microtubule-Associated Proteins; D008875:Middle Aged; D009849:Olivopontocerebellar Atrophies / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D010751:Phosphopyruvate Hydratase; D011689:Purkinje Cells / Q000648:ultrastructure; D013132:Spinocerebellar Degenerations / Q000473:pathology*
chemical_list: D008869:Microtubule-Associated Proteins; D005968:Glutamate Decarboxylase; D010751:Phosphopyruvate Hydratase