Pharmacokinetics of albendazole administered by an intraruminal pulse release electronic device in cattle.
Albendazole was administered to 12 young Charolais cattle, 300 kg bodyweight, using an intraruminal pulse release electronic device. The device released 2 g albendazole three times at 31 day intervals. The kinetic study of two main metabolites of albendazole in all animals at the time of each release showed that on 36 occasions the devices worked at the expected time; the mean kinetic profiles were nearly identical at first, second and third release. A good repeatability was generally also noticed for each animal individually; the bioavailability of the drug did not seem to be different from that obtained after administration of albendazole as an oral drench.
Delatour
P
P
National School of Veterinary Medicine of Lyons, France.
Gyurik
R J
RJ
Benoit
E
E
Garnier
F
F
D000284:Administration, Oral / Q000295:instrumentation* / Q000662:veterinary; D015766:Albendazole; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D002417:Cattle / Q000378:metabolism*; D004582:Electronics, Medical / Q000295:instrumentation*; D005260:Female; D008297:Male; D012417:Rumen
D000871:Anthelmintics; D001562:Benzimidazoles; D015766:Albendazole