title: [Transfer of cefmenoxime to lung tissue and thoracic muscle in thoracic surgery].
abstract: Twenty patients who were performed pulmonary resection for the disease of the lung were administered 2 g of cefmenoxime (CMX) intravenously during the operation. The CMX levels in serum, lung tissue and thoracic muscle were measured by agar-well technique. The CMX levels in lung tissue and thoracic muscle were higher than the MIC80 of CMX for Klebsiella pneumoniae, Haemophilus influenzae and Streptococcus pneumoniae which were commonly as isolated causative organisms from the patients with pulmonary infection. These results indicate that CMX will be useful agent for the prevention and treatment of pulmonary infection.
authors.forename: Y
authors.initials: Y
authors.lastname: Teranishi
authors.forename: T
authors.initials: T
authors.lastname: Tazaki
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Honda
authors.forename: A
authors.initials: A
authors.lastname: Ohishi
authors.forename: Y
authors.initials: Y
authors.lastname: Endoh
authors.forename: O
authors.initials: O
authors.lastname: Konno
authors.forename: A
authors.initials: A
authors.lastname: Usuba
authors.forename: H
authors.initials: H
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Shoji
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000517:prevention & control; D015281:Cefmenoxime; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008168:Lung / Q000378:metabolism*; D008171:Lung Diseases / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010369:Pectoralis Muscles / Q000378:metabolism*; D011183:Postoperative Complications / Q000517:prevention & control
chemical_list: D015281:Cefmenoxime; D002439:Cefotaxime