Comparative anti-influenza vaccination of some groups of the population with vaccines differing in virus purification level.
A total of 1215 persons, divided into 4 groups, were immunized with influenza vaccines A (highly purified, whole-virion), B (subunit, containing H and M), and C (conventional, commercial partly purified by Sharplers centrifugation). Post-vaccination reactions were followed, and serological tests (HI and NI) were performed with serum specimens taken from each vaccine 4 times during and after the vaccination period. The results point to clear superiority of purified and subunit vaccines over the conventional one.
Brydak
L
L
Department of Virology, National Institute of Hygiene, Warsaw.
Gall
W
W
Semkow
R
R
D000914:Antibodies, Viral / Q000096:biosynthesis; D006801:Humans; D007249:Inflammation / Q000209:etiology; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000009:adverse effects / Q000302:isolation & purification / Q000627:therapeutic use*; D007251:Influenza, Human / Q000517:prevention & control*; D010146:Pain / Q000209:etiology
D000914:Antibodies, Viral; D007252:Influenza Vaccines