title: [Rearrangement of the short arm of chromosome 12 in chronic myelomonocytic leukemias].
abstract: A rearrangement of the short arm of chromosome #12 with a breakpoint at band 12 was found in 4 out of 15 patients with CMML: two deletions, one simple translocation (9;12)(p21;p12) and one complex t(11;12;13)(p11;p12;q21). Their haematological and clinical characteristics were investigated together with those of 5 other similar published cases. Although this alteration is not very frequent in this myelodysplastic syndrome, and is also found in various other malignant blood disorders, it is clearly a non-random phenomenon, the consequences of which are discussed.
authors.forename: J
authors.initials: J
authors.lastname: Tanzer
authors.forename: M
authors.initials: M
authors.lastname: Lessard
authors.forename: F
authors.initials: F
authors.lastname: Guilhot
authors.forename: A
authors.initials: A
authors.lastname: Brizard
mesh_terms: D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002881:Chromosomes, Human, Pair 12; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*
vernacular_title: Remaniement du petit bras du chromosome 12 dans les leucémies myélomonocytaires chroniques (LMMC).