Effects of phenothiazines and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide on rat colonic absorption of cefmetazole.
Rat colonic absorption of cefmetazole was increased significantly by calmodulin inhibitors such as phenothiazines and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) when they were coadministered at a concentration between 1 and 100 microM. The bioavailability of cefmetazole, determined by area under the blood concentration curve method, increased 20 to 30% by the coadministration of calmodulin inhibitors. It is speculated that the enhancing action of agents on rat colonic absorption of cefmetazole takes place by a paracellular route and coadministration of sodium ion increases their actions.
Suzuka
T
T
Furuya
A
A
Kamada
A
A
Nishihata
T
T
D000818:Animals; D001682:Biological Availability; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D015311:Cefmetazole; D002513:Cephamycins / Q000097:blood / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003106:Colon / Q000187:drug effects / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D010546:Perphenazine / Q000494:pharmacology; D010640:Phenothiazines / Q000008:administration & dosage / Q000494:pharmacology*; D011398:Promethazine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013449:Sulfonamides / Q000494:pharmacology*; D014268:Trifluoperazine / Q000494:pharmacology
D002147:Calmodulin; D002513:Cephamycins; D010640:Phenothiazines; D013449:Sulfonamides; D014268:Trifluoperazine; D015311:Cefmetazole; C017967:W 7; D011398:Promethazine; D010546:Perphenazine