title: Effects of maternal nutritional status on fetal and placental growth and on fetal urea synthesis in sheep.
abstract: Fetal and placental growth, and fetal and maternal urea synthesis in late gestation, were studied in 2-year-old Corriedale ewes on a maintenance ration (M) except when subjected to moderate dietary restriction from day 50 to day 100 (RM), day 100 to day 135 (MR) or day 50 to day 135 (RR). In comparison with fetuses of ewes maintained throughout the experiment (MM), RR fetuses were smaller and RM fetuses were larger whereas MR fetuses were unaffected; all restrictions were associated with increased placental size. Fetal urea synthesis at day 133 in the well-nourished ewes (MM) was 21.5 mg N h-1 kg-1 increasing to, respectively, 25.7, 27.3 and 38.8 mg N h-1 kg-1 in groups MR, RM and RR; these values were 1.6, 3.9, 2.2 and 3.8 times the maternal rates of synthesis. On the basis of the observed urea synthesis rates, amino acid oxidation could have accounted for up to, respectively, 32, 38, 40 and 57% of fetal oxygen consumption in groups MM, MR, RM and RR. Amino acids, in addition to their role in tissue accretion, may be key energy substrates for the fetus.
authors.affiliation: Division of Animal Production, CSIRO, Blacktown, N.S.W., Australia.
authors.forename: G J
authors.initials: GJ
authors.lastname: Faichney
authors.forename: G A
authors.initials: GA
authors.lastname: White
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D004063:Digestion; D005314:Embryonic and Fetal Development; D005260:Female; D005333:Fetus / Q000378:metabolism; D005865:Gestational Age; D008431:Maternal-Fetal Exchange; D009752:Nutritional Status; D010920:Placenta / Q000033:anatomy & histology; D011247:Pregnancy; D012756:Sheep; D014508:Urea / Q000096:biosynthesis*
chemical_list: D001786:Blood Glucose; D014508:Urea