[Population genetics study of differential fertility in humans (based on an example of habitual abortion). II. Distribution of genotypes and heterozygosity levels for a variety of biochemical markers].
Hereditary variation of 21 blood proteins coded by 22 monomorphic and 9 polymorphic loci was compared in 171 couples and 120 women with repeated spontaneous abortions in anamnesis (experimental group) and 183 couples with normal fertility (control group). Significant elevation of frequency of rare protein electrophoretic variants, marked deviation in distribution of genotypes for polymorphic loci, alteration in observed heterozygosity level were not found in experimental group. Statistically significant decrease in average value of D index (D = (hobs-hexp)/hexp; hobs, hexp--observed and expected heterozygosity per locus) was found in women of experimental group.
Ikramov
K M
KM
Dubrova
Iu E
IuE
Altukhov
Iu P
IuP
Podogas
A V
AV
D000026:Abortion, Habitual / Q000097:blood / Q000235:genetics*; D001798:Blood Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D011110:Polymorphism, Genetic; D011247:Pregnancy
D001798:Blood Proteins; D005819:Genetic Markers
Populiatsionno-geneticheskoe izuchenie differentsial'noĭ plodovitosticheloveka (na primere privychnogo nevynashivaniia beremennosti). Soobshchenie II. Raspredelenie genotipov i urovni geterozigotnosti po sovokupnosti biokhimicheskikh markerov genov.