title: Sulfites and skin pathology in children.
abstract: We report the case of 8 children (whose ages ranged between 2 and 7) who consulted us because of urticaria, accompanied by angioedema in 5 of the cases. An additives study was performed based on a habitual program. Sodium bisulfite hypersensitivity was detected with oral provocation test with doses of 5 and 25 mgs. The tests were positive within the first hour of observation in 2 cases, in the rest the reaction appeared later after the administration of the second dose; the reaction in 2 of the cases were semi-delayed. No respiratory symptomatology was detected in these patients.
authors.affiliation: Servicio de Alergia e Inmunologia Clinica, Hospital Infantil Valle de Hebron, Universidad Autonoma de Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Botey
authors.forename: M
authors.initials: M
authors.lastname: Cozzo
authors.forename: J L
authors.initials: JL
authors.lastname: Eseverri
authors.forename: A
authors.initials: A
authors.lastname: Marín
mesh_terms: D000799:Angioedema / Q000139:chemically induced*; D000975:Antioxidants / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D005512:Food Hypersensitivity / Q000209:etiology; D005520:Food Preservatives / Q000009:adverse effects; D006801:Humans; D008297:Male; D013447:Sulfites / Q000009:adverse effects*; D014581:Urticaria / Q000139:chemically induced*
chemical_list: D000975:Antioxidants; D005520:Food Preservatives; D013447:Sulfites; C009279:sodium bisulfite