Vitamin A-enhanced cleft palate susceptibility associated with H-2.
Pregnant mice from the congenic strains C57BL/10Sn, B10.BR, B10.A/SgSn, B10.A(5R)/SgSn, B10.A(2R)SgSn and B10.A(18R)Sg were fed Purina Laboratory Chow or the same diet plus approximately 400 IU vitamin A daily and given 80 mg/kg dexamethasone intra-peritoneally or a sham injection on the 12th day of pregnancy. It was found that only strains with b alleles between H-2S and H-2D had significantly higher frequencies of isolated cleft palate among their progeny when fed the supplemental vitamin A. The locus appears to be on the centromeric side of a dexamethasone-induced cleft palate gene which has been mapped to the same general area.
Tyan
M L
ML
Medical Service, Wadsworth VA Medical Center, Los Angeles, CA 90073.
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D002972:Cleft Palate / Q000139:chemically induced / Q000235:genetics*; D003907:Dexamethasone; D004198:Disease Susceptibility; D005260:Female; D006183:H-2 Antigens / Q000235:genetics*; D006239:Haplotypes; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D013045:Species Specificity; D014801:Vitamin A / Q000633:toxicity*
D006183:H-2 Antigens; D014801:Vitamin A; D003907:Dexamethasone