Somatomedin-C/insulin-like growth factor-1 in infants with congenital hypothyroidism during the first week of life.
Levels of somatomedin-C/insulin-like growth factor-1 (Sm-C/IGF-1) were determined in whole blood collected on filter paper from 41 newborns with congenital hypothyroidism and 183 full-term neonates with normal thyroid function. The mean Sm-C/IGF-1 value of the untreated hypothyroid infants (0.10 U/ml) was virtually identical with that of the normal controls (0.11 U/ml). We are unable to confirm earlier findings of others that Sm-C/IGF-1 concentrations are lower in hypothyroid newborns than in normal infants.
Mitchell
M L
ML
Massachusetts Department of Public Health, State Laboratory Institute, Jamaica Plain 02130.
Hermos
R J
RJ
Moses
A C
AC
D003409:Congenital Hypothyroidism; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood*; D007231:Infant, Newborn / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000097:blood*; D008297:Male; D012016:Reference Values; D013002:Somatomedins / Q000097:blood*; D013997:Time Factors
D013002:Somatomedins; D007334:Insulin-Like Growth Factor I