Vascular responses of isolated, perfused canine femoral arteries and veins to vasoactive substances.
The stainless steel cannula inserting method was used to observe vascular effects of 9 vasoactive substances on the isolated, perfused canine femoral artery and vein. In the vein, the order of potency for inducing vasoconstriction was norepinephrine greater than histamine = phenylephrine = serotonin greater than prostaglandin F2 alpha greater than ATP greater than xylazine greater than tyramine much greater than KCl. It was demonstrated that the cannula inserting method is useful for observations of venous vascular reactivity.
Kawai
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K
Chiba
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S
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000187:drug effects*; D015237:Dinoprost; D004285:Dogs; D005260:Female; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D014439:Tyramine / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014680:Veins / Q000187:drug effects*; D014991:Xylazine / Q000494:pharmacology
D011460:Prostaglandins F; D014662:Vasoconstrictor Agents; D010656:Phenylephrine; D014991:Xylazine; D012701:Serotonin; D011189:Potassium Chloride; D006632:Histamine; D000255:Adenosine Triphosphate; D015237:Dinoprost; D009638:Norepinephrine; D014439:Tyramine