title: Recessive cancer genes in meningiomas? An analysis of 31 cases.
abstract: Cytogenetic studies on 31 human meningiomas revealed clonal abnormalities in 14 of them. Monosomy 22 was present in three cases as the only abnormality, and in five it was associated with monosomy 18, monosomy 14, loss of X, loss of Y, and trisomy 20, respectively. We found a number of rearrangements involving chromosome #22: an i psu dic(22)(pter----q11::q11----pter) in two cases and a t(18;22)(q12;q11) in another case. Two cases showed a complex translocation involving #7 and #14: t(2;7;14)(q23;q36;q22) and t(1;7;14)(q25;q32;q22), respectively. Other clonal chromosome abnormalities were del(1p) (present in two cases); der(9)t(9;?)(q34;?); der(7)t(7;?)(q31;?); der(22)t(22;?)(q11;?); and a 9p+ chromosome. The relevance for the pathogenesis of human meningiomas of these chromosome anomalies is also discussed with reference to the previous literature. The possible involvement of recessive cancer genes present on the long arm of chromosome #22 is also discussed.
authors.forename: R
authors.initials: R
authors.lastname: Casalone
authors.forename: P
authors.initials: P
authors.lastname: Granata
authors.forename: P
authors.initials: P
authors.lastname: Simi
authors.forename: E
authors.initials: E
authors.lastname: Tarantino
authors.forename: G
authors.initials: G
authors.lastname: Butti
authors.forename: R
authors.initials: R
authors.lastname: Buonaguidi
authors.forename: F
authors.initials: F
authors.lastname: Faggionato
authors.forename: R
authors.initials: R
authors.lastname: Knerich
authors.forename: L
authors.initials: L
authors.lastname: Solero
mesh_terms: D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D005808:Genes, Recessive; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics*; D008579:Meningioma / Q000235:genetics*; D008875:Middle Aged
chemical_list: D005819:Genetic Markers