Analgesic activity following combined oral administration of flupirtine maleate and peripherally acting analgesics in mice and rats.
Concomitant administration of flupirtine maleate at a single low dose (15 mg/kg, mice; 35 mg/kg, rats) with a wide range of doses of each of the peripherally acting analgesics enhanced the antinociceptive activity of paracetamol, acetylsalicyclic acid and ibuprofen in the acetic acid writhing test, acetylsalicylic acid in the hot plate test and paracetamol, acetylsalicyclic acid and ibuprofen in the Randall-Selitto test. The concomitant administration of a single low dose of the peripherally acting analgesics (at about 1/2 ED50) with a wide range of doses of flupirtine maleate resulted in enhancement of flupirtine maleate analgesic activity by paracetamol (in the hot plate and Randall-Selitto tests), acetylsalicyclic acid (in the acetic acid writhing test), ibuprofen (in the Randall-Selitto test) and indomethacin (in the acetic acid and Randall-Selitto tests). Thus flupirtine maleate enhanced the analgesic activity of paracetamol, acetylsalicyclic acid and ibuprofen in mice and rats. Each of the peripherally acting analgesics enhanced the analgesic activity of flupirtine maleate in one or more of the analgesic tests used.
Diamantis
W
W
Department of Pharmacology, Wallace Laboratories, Div. of Carter-Wallace, Inc., Cranbury, New Jersey 08512.
Gordon
R
R
Sofia
R D
RD
D000082:Acetaminophen / Q000008:administration & dosage / Q000494:pharmacology; D000284:Administration, Oral; D000631:Aminopyridines / Q000008:administration & dosage / Q000494:pharmacology*; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004357:Drug Synergism; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010147:Pain Measurement; D010525:Peripheral Nerves / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000631:Aminopyridines; D000700:Analgesics; D000082:Acetaminophen; C034161:flupirtine; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin