Construction of transferrin-coated liposomes for in vivo transport of exogenous DNA to bone marrow erythroblasts in rabbits.
A method for coating liposomes with transferrin is described. Such liposomes have been used for carrying exogenous DNA to rabbit bone marrow (BM) precursor cells, in vivo. A large amount of the DNA contained in the liposomes was delivered specifically into the erythroblasts of the test animals.
Stavridis
J C
JC
Deliconstantinos
G
G
Psallidopoulos
M C
MC
Armenakas
N A
NA
Hadjiminas
D J
DJ
Hadjiminas
J
J
D000818:Animals; D001854:Bone Marrow Cells; D004247:DNA / Q000008:administration & dosage* / Q000378:metabolism; D004900:Erythroblasts / Q000378:metabolism*; D005818:Genetic Engineering; D007275:Injections, Intravenous; D008081:Liposomes / Q000008:administration & dosage* / Q000378:metabolism; D011485:Protein Binding; D011817:Rabbits; D014168:Transferrin / Q000008:administration & dosage*; D014170:Transformation, Genetic
D008081:Liposomes; D014168:Transferrin; D004247:DNA