A T cell receptor V beta segment that imparts reactivity to a class II major histocompatibility complex product.
We have identified in mice an allele of a new T cell receptor V beta gene, V beta 17a, whose product is bound by the monoclonal antibody KJ23a. Over 90% of T cell hybridomas prepared from V beta 17a+ T cells of SWR mice respond to allogeneic forms of the IE class II MHC protein, indicating that V beta 17a has an appreciable affinity for IE regardless of the other components of the T cell receptor. These results suggest a bias in the germ-line T cell receptor repertoire toward recognition of MHC proteins and indicate that the V beta portion of the receptor may form the most important contact points with MHC ligands.
Kappler
J W
JW
Wade
T
T
White
J
J
Kushnir
E
E
Blackman
M
M
Bill
J
J
Roehm
N
N
Marrack
P
P
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D005796:Genes; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D008285:Major Histocompatibility Complex; D051379:Mice; D011110:Polymorphism, Genetic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000276:immunology
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II; D011948:Receptors, Antigen, T-Cell