title: Tumor uptake of 5-fluorouracil, methotrexate, and adriamycin vs gallium.
abstract: Since the imaging pattern of 67Ga-citrate is well known, it can be the benchmark for evaluation of potential tumor imaging agents. Tritium labeled 5-fluorouracil, Adriamycin, (doxorubicin/Adria) and Methotrexate/Lederle were compared at 2 h to 67Ga-citrate at 2 and 48 h by percent uptake per gram of various tissues and tumor in rats implanted with Walker 256 carcinosarcoma. 67Ga at 48 h showed approximately three times more uptake in the tumor than 5 fluorouracil and eight times more than the others. 5 Fluorouracil showed approximately three times greater uptake than Methotrexate or doxorubicin and 1.4 times the 2 h uptake of 67Ga. 5 Fluorouracil shows potential as an imaging agent especially where the waiting time between injection and imaging must be short.
authors.forename: M M
authors.initials: MM
authors.lastname: Webber
authors.forename: R
authors.initials: R
authors.lastname: Verma
authors.forename: B
authors.initials: B
authors.lastname: Chang
mesh_terms: D000818:Animals; D002279:Carcinoma 256, Walker / Q000000981:diagnostic imaging / Q000378:metabolism*; D004317:Doxorubicin / Q000378:metabolism*; D005260:Female; D005472:Fluorouracil / Q000378:metabolism*; D005710:Gallium Radioisotopes / Q000378:metabolism*; D007700:Kinetics; D008727:Methotrexate / Q000378:metabolism*; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014316:Tritium
chemical_list: D005710:Gallium Radioisotopes; D014316:Tritium; D004317:Doxorubicin; D005472:Fluorouracil; D008727:Methotrexate