title: Glucose-stimulated acidogenesis by Streptomyces peucetius.
abstract: Cultures of Streptomyces peucetius often were observed to divert spontaneously from the production of anthracycline antibiotics to the excretion of acidic metabolites, whether grown in a defined medium or a nutrient-rich medium. The predominant excreted acidic metabolites were determined by high-performance liquid chromatography to be pyruvate and 2-oxoglutarate. The acidification occurred at high frequencies when glucose was the primary carbon source in a defined medium, at intermediate frequencies when fructose was the primary carbon source, and did not occur when either maltose, starch, or dextrin were used as primary carbon sources.
authors.affiliation: Department of Microbiology, Ohio State University, Columbus 43210.
authors.forename: M L
authors.initials: ML
authors.lastname: Dekleva
authors.forename: W R
authors.initials: WR
authors.lastname: Strohl
mesh_terms: D003470:Culture Media; D005285:Fermentation; D005947:Glucose / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D013302:Streptomyces / Q000254:growth & development*
chemical_list: D003470:Culture Media; D005947:Glucose