The gene encoding for the major brain proteolipid (PLP) maps on the q-22 band of the human X chromosome.
Recombinant plasmid clone p23 containing the cDNA proteolipid (PLP) sequence was localized by in situ hybridization on band q22 of the human X chromosome. This localization may have implications for X-linked demyelination diseases such as Pelizaeus-Merzbacher disease in man.
Mattei
M G
MG
Alliel
P M
PM
Dautigny
A
A
Passage
E
E
Pham-Dinh
D
D
Mattei
J F
JF
Jollès
P
P
D001923:Brain Chemistry; D002871:Chromosome Banding; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D009693:Nucleic Acid Hybridization; D011510:Proteolipids / Q000235:genetics*; D014960:X Chromosome
D005819:Genetic Markers; D011510:Proteolipids; D004247:DNA