In vivo and in vitro study of the effects of vitamin A deficiency on rat third molar development.
We have examined the effect of in vivo vitamin A status on subsequent rat third molar formation and mineralization in an in vitro organ culture system. Vitamin A deficiency imposed during an eight-day in vitro period caused effects very similar to those of vitamin A deficiency imposed on rats in vivo. Analysis of the data also demonstrates that retinoic acid is capable of reversing the interference in mineralization of third molars induced by vitamin A deficiency in the organ culture system.
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D000818:Animals; D002118:Calcium / Q000032:analysis; D066298:In Vitro Techniques; D008964:Molar, Third / Q000032:analysis / Q000187:drug effects / Q000503:physiopathology*; D009805:Odontogenesis / Q000187:drug effects; D010758:Phosphorus / Q000032:analysis; D011506:Proteins / Q000032:analysis; D051381:Rats; D014212:Tretinoin / Q000494:pharmacology; D014801:Vitamin A / Q000097:blood; D014802:Vitamin A Deficiency / Q000378:metabolism / Q000503:physiopathology*
D011506:Proteins; D014801:Vitamin A; D010758:Phosphorus; D014212:Tretinoin; D002118:Calcium