Thyroid function and reversal by antidepressant drugs of depressive-like behavior (escape deficits) in rats.
Several investigations have suggested that a special relationship exists between thyroid function and affective disorders and/or therapeutic response to antidepressants. The present study shows that the reversal by clomipramine, desipramine, imipramine and nialamide of depressive-like behavior in rats (escape deficits produced by previous exposure to uncontrollable stress) was markedly attenuated in hypothyroid rats (propylthiouracil, 0.05% in the drinking water). Conversely, the effect of these same antidepressants was significantly hastened in euthyroid rats given daily triiodothyronine. This supports the notion of intricate thyroid/CNS interactions in the mechanisms of action of antidepressant drugs.
Martin
P
P
Département de Pharmacologie, INSERM U 302, Paris, France.
Massol
J
J
Belon
J P
JP
Gaudel
G
G
Soubrié
P
P
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D002997:Clomipramine / Q000494:pharmacology; D003891:Desipramine / Q000378:metabolism / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004924:Escape Reaction / Q000187:drug effects*; D007037:Hypothyroidism / Q000139:chemically induced; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D009526:Nialamide / Q000494:pharmacology; D011441:Propylthiouracil; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000378:metabolism / Q000502:physiology*; D014284:Triiodothyronine
D000928:Antidepressive Agents; D014284:Triiodothyronine; D011441:Propylthiouracil; D002997:Clomipramine; D007099:Imipramine; D009526:Nialamide; D003891:Desipramine