title: Bacteriophage infection--a possible mechanism for increased virulence of bacteria associated with rapidly destructive periodontitis.
abstract: We have recently isolated several groups of bacteriophages infecting Actinobacillus actinomycetemcomitans from periodontal lesions in patients with rapidly destructive periodontitis. Bacteriophage infection of these bacteria in these patients was restricted to periodontal pockets showing radiographic evidence of recent bone loss and suggests an association between phage-infected A. actinomycetemcomitans and active periodontal disease. On the basis of the biological activity of bacteriophages we propose a working hypothesis to explain the mechanism by which a phage may increase bacterial virulence in periodontal disease.
authors.forename: H R
authors.initials: HR
authors.lastname: Preus
authors.forename: I
authors.initials: I
authors.lastname: Olsen
authors.forename: P
authors.initials: P
authors.lastname: Gjermo
mesh_terms: D000188:Actinobacillus / Q000472:pathogenicity; D000293:Adolescent; D000328:Adult; D000368:Aged; D010520:Aggressive Periodontitis / Q000382:microbiology; D001433:Bacteriolysis; D001435:Bacteriophages / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005098:Exotoxins / Q000096:biosynthesis; D006801:Humans; D008875:Middle Aged; D010518:Periodontitis / Q000382:microbiology* / Q000503:physiopathology; D010519:Periodontium / Q000382:microbiology; D014774:Virulence
chemical_list: D005098:Exotoxins; C018579:leukotoxin