Toxicity of polycyclic aromatic hydrocarbons. V. Protective effect of beta-naphthoflavone against hepatotoxicity induced by diphenaldehyde in rats.
Male Sprague-Dawley rats were treated ip with beta-naphthoflavone (40 mg/kg/day) in corn oil or in DMSO for three days. Diphenaldehyde (90 mg/kg in DMSO) was injected ip 24 hr after pretreatment. The increase in the levels of aspartate aminotransferase, alanine aminotransferase, sorbitol dehydrogenase, gamma glutamyl transpeptidase, and lactate dehydrogenase was significantly lower in rats pretreated with BNF. This suggests that the BNF-induced P-450 isozyme systems have a protective effect against the acute hepatotoxicity of diphenaldehyde.
Yoshikawa
T
T
Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Flory
W
W
Giamalva
D H
DH
Ruhr
L P
LP
Church
D F
DF
Pryor
W A
WA
D000447:Aldehydes / Q000633:toxicity*; D000818:Animals; D001571:Benzoflavones / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010126:Ozone / Q000633:toxicity*; D010616:Phenanthrenes / Q000633:toxicity*; D011083:Polycyclic Compounds / Q000037:antagonists & inhibitors / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D019324:beta-Naphthoflavone
D000447:Aldehydes; D001571:Benzoflavones; D005419:Flavonoids; D010616:Phenanthrenes; D011083:Polycyclic Compounds; C056469:diphenaldehyde; C031181:phenanthrene; D019324:beta-Naphthoflavone; D010126:Ozone; D006899:Mixed Function Oxygenases