Human T-cell receptor genes: organization, diversity, and polymorphism.
The analysis of 27 human beta cDNA clones has revealed striking insights as to the germ line, combinatorial, and somatic mechanisms that operate to diversify V beta gene segments. It appears that the repertoire of human V beta genes is limited to 60 or so functional gene segments. Deletional mapping together with the analysis of large DNA fragments by field inversion gel electrophoresis and the isolation of cosmid clones should permit us to map the entire human V beta gene family. The polymorphisms that are present in these V beta gene segments will facilitate a search for interesting disease associations. A detailed comparison of the mouse and human V beta loci should permit us to come to understand in more detail the evolutionary mechanisms that have created these fascinating gene families.
Concannon
P
P
Lai
E
E
Klein
M
M
Siu
S
S
Strauss
E
E
Pickering
L
L
Kung
P
P
Gatti
R
R
Hood
L
L
D001483:Base Sequence; D002872:Chromosome Deletion; D005787:Gene Frequency; D005796:Genes; D008040:Genetic Linkage; D014644:Genetic Variation; D006801:Humans; D011110:Polymorphism, Genetic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*
D011948:Receptors, Antigen, T-Cell