title: Exogenous glutathione protects intestinal epithelial cells from oxidative injury.
abstract: Exogenous GSH provided rat small-intestinal epithelial cells with significant protection against injury induced by t-butyl hydroperoxide or menadione. This protection was found to be dependent upon uptake of intact GSH. Uptake of GSH occurred by a Na+-dependent electrogenic system found in the basolateral membrane. Thus, rat small-intestinal epithelial cells can utilize plasma GSH to support intracellular detoxication systems that function in protection against chemically induced injury.
authors.forename: L H
authors.initials: LH
authors.lastname: Lash
authors.forename: T M
authors.initials: TM
authors.lastname: Hagen
authors.forename: D P
authors.initials: DP
authors.lastname: Jones
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D002462:Cell Membrane / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism / Q000494:pharmacology*; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010545:Peroxides / Q000037:antagonists & inhibitors* / Q000633:toxicity; D011339:Probenecid / Q000494:pharmacology; D051381:Rats; D012964:Sodium / Q000378:metabolism; D014812:Vitamin K / Q000037:antagonists & inhibitors* / Q000633:toxicity; D020122:tert-Butylhydroperoxide
chemical_list: D010545:Peroxides; D014812:Vitamin K; D020122:tert-Butylhydroperoxide; D012964:Sodium; D005978:Glutathione; D011339:Probenecid