title: The effects of a dentifrice containing zinc citrate and 2,4,4' trichloro-2'-hydroxydiphenyl ether.
abstract: The effects of a dentifrice which contained 1% zinc citrate and 0.5% of a nonionic antimicrobial agent, 2,4,4' trichloro-2'-hydroxydiphenyl ether on plaque and gingival health have been investigated. In a 4-day nonbrushing study in which dentifrices were used as slurries, this dentifrice inhibited plaque accumulation significantly more than dentifrices which contained either zinc citrate or Triclosan separately. In a 28-day double-blind cross-over study, a significant reduction in plaque accumulation and improvement in gingival health was demonstrated for the test dentifrice compared to the placebo. The effect was demonstrated with a group of well motivated volunteers who had a good standard of oral health. Analysis of the data suggested that the benefit might be extended to a less motivated population.
authors.forename: C A
authors.initials: CA
authors.lastname: Saxton
mesh_terms: D000328:Adult; D002951:Citrates / Q000008:administration & dosage / Q000494:pharmacology*; D019343:Citric Acid; D003773:Dental Plaque / Q000209:etiology* / Q000517:prevention & control; D003802:Dentifrices / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005891:Gingivitis / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D010647:Phenyl Ethers / Q000494:pharmacology*; D010919:Placebos; D013997:Time Factors; D014260:Triclosan / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D002951:Citrates; D003802:Dentifrices; D004338:Drug Combinations; D010647:Phenyl Ethers; D010919:Placebos; D019343:Citric Acid; D014260:Triclosan