A gene (Bmn) controlling beta-mannosidase activity in the mouse is located in the distal part of chromosome 3.
A gene (Bmn) with a major effect on beta-mannosidase activity in kidney and liver of the house mouse was revealed by assay with the synthetic substrate p-nitrophenyl-beta-D-mannoside. Activity is low in DBA/2J and CSB mice and high in C57BL/6J mice. By the use of the BXD series of recombinant inbred strains and by crosses between C57BL and CSB, it was possible to map the gene to the distal part of chromosome 3 by demonstration of linkage to a gene for cadmium resistance, cdm, as well as to the Adh-3 locus.
Lundin
L G
LG
Department of Medical & Physiological Chemistry, Uppsala, Sweden.
D000426:Alcohol Dehydrogenase / Q000235:genetics; D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008297:Male; D008361:Mannosidases / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D012737:Sex Factors; D044902:beta-Mannosidase
D002104:Cadmium; D000426:Alcohol Dehydrogenase; D008361:Mannosidases; D044902:beta-Mannosidase