The bioavailability and pharmacodynamics of chlormethiazole in healthy young and elderly volunteers: preliminary findings.
A preliminary analysis of a study of the bioavailability and pharmacodynamics of chlormethiazole in healthy young and elderly volunteers has been performed. The bioavailability assessed by a stable isotope method and the pharmacodynamic effects assessed by psychometric tests were found not to differ between the two age groups.
Jostell
K G
KG
Fagan
D
D
Björk
M
M
Broberg
F
F
Mitchell
R M
RM
Scott
D B
DB
Ulff
B
B
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001143:Arousal / Q000187:drug effects; D001288:Attention / Q000187:drug effects; D001682:Biological Availability; D002719:Chlormethiazole / Q000097:blood* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011597:Psychomotor Performance / Q000187:drug effects
D002719:Chlormethiazole