title: Mandibular growth following Le Fort I osteotomy in adolescent monkeys.
abstract: Le Fort I osteotomy with anterior and superior repositioning of the maxilla was performed on adolescent Macaca fascicularis monkeys to study its effect on the subsequent growth and remodeling changes of the mandible. Six adolescent Macaca fascicularis monkeys were randomly divided into two surgical groups and eight others served as controls. Group I animals underwent a Le Fort I advancement and Group II animals experienced a Le Fort I advancement and impaction. All monkeys received tantalum implants in the anterior part of the cranial base, on opposite sides of craniofacial sutures and in multiple sites of the maxilla and mandible. The immediate postsurgical occlusion of all experimental animals was a Class II molar relationship. The animals were followed for up to 12 months postoperatively. Analysis of cephalometric head films taken at monthly intervals showed that both the maxilla and the mandible of all experimental monkeys grew in a coordinated fashion, although the amount, rate, and direction of growth varied between control and experimental animals as well as between Group I and Group II animals. The largest increments and rates of growth were observed in the control animals, Group I animals, and Group II animals, respectively. This study indicates that the growth changes in both maxilla and mandible are related to the extent of injury caused by maxillary surgery. The results also showed that although the surgical procedures were performed in the maxilla, mandibular growth was significantly modulated by the surgically changed maxillary environment.
authors.forename: R
authors.initials: R
authors.lastname: Nanda
authors.forename: O
authors.initials: O
authors.lastname: Bouayad
authors.forename: R G
authors.initials: RG
authors.lastname: Topazian
mesh_terms: D000818:Animals; D001862:Bone Resorption; D002508:Cephalometry; D003766:Dental Occlusion; D005260:Female; D008252:Macaca fascicularis; D008334:Mandible / Q000033:anatomy & histology / Q000254:growth & development*; D008335:Mandibular Condyle / Q000033:anatomy & histology; D008437:Maxilla / Q000254:growth & development / Q000601:surgery*; D010012:Osteogenesis; D010027:Osteotomy / Q000379:methods*; D019736:Prostheses and Implants; D013635:Tantalum; D014716:Vertical Dimension
chemical_list: D013635:Tantalum