title: Genetics of susceptibility to oral tolerance to ovalbumin.
abstract: Inbred mouse strains vary widely in their susceptibility to the induction of tolerance following oral (intragastric) administration of ovalbumin. Marked differences were found between strains that form a congenic pair differing at the H-2 complex: C3H/HeJ (H-2k) and C3H.SW (H-2b)-which were very susceptible and resistant to tolerance induction, respectively. In contrast, no significant differences were found between A/J (H-2a) and A.BY (H-2b) congenics, which were both susceptible, nor among C57BL/10J congenics, which were uniformly resistant to tolerance induction. We conclude that H-2-linked genes determine tolerance susceptibility in conjunction with background genes.
authors.affiliation: Departamento de Bioquímica-Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
authors.forename: N M
authors.initials: NM
authors.lastname: Vaz
authors.forename: M J
authors.initials: MJ
authors.lastname: Rios
authors.forename: L M
authors.initials: LM
authors.lastname: Lopes
authors.forename: C M
authors.initials: CM
authors.lastname: Gontijo
authors.forename: E B
authors.initials: EB
authors.lastname: Castanheira
authors.forename: F
authors.initials: F
authors.lastname: Jacquemart
authors.forename: L A
authors.initials: LA
authors.lastname: Andrade
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004361:Drug Tolerance; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006183:H-2 Antigens / Q000235:genetics*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000378:metabolism; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008814:Mice, Inbred NZB; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology* / Q000378:metabolism; D013045:Species Specificity
chemical_list: D006183:H-2 Antigens; D010047:Ovalbumin