title: Proteins secreted by day-16 to -18 bovine conceptuses extend corpus luteum function in cows.
abstract: Corpus luteum function, interoestrous interval and spontaneous uterine PGF-2 alpha (PGF) production were evaluated in 9 cyclic Holstein cows (3/group) after intrauterine injections of pooled conceptus secretory proteins, 5 beta-pregnan-3 alpha-ol-20-one, or homologous serum proteins on Days 15.5 through 21 after oestrus. A significant extension of corpus luteum lifespan and interoestrous interval were detected in cows treated with conceptus secretory proteins compared to the other 2 groups. CL lifespan and interoestrous interval were not different (P greater than 0.25) between 5 beta-pregnan-3 alpha-ol-20-one and control groups. Evaluation of spontaneous PGF responses suggested that proteins synthesized and secreted by the bovine conceptus accommodate luteal maintenance during early gestation via an attenuation of endometrial PGF production.
authors.forename: J J
authors.initials: JJ
authors.lastname: Knickerbocker
authors.forename: W W
authors.initials: WW
authors.lastname: Thatcher
authors.forename: F W
authors.initials: FW
authors.lastname: Bazer
authors.forename: M
authors.initials: M
authors.lastname: Drost
authors.forename: D H
authors.initials: DH
authors.lastname: Barron
authors.forename: K B
authors.initials: KB
authors.lastname: Fincher
authors.forename: R M
authors.initials: RM
authors.lastname: Roberts
mesh_terms: D000818:Animals; D002417:Cattle; D003338:Corpus Luteum / Q000502:physiology*; D015237:Dinoprost; D004622:Embryo, Mammalian / Q000502:physiology*; D004971:Estrus / Q000187:drug effects; D005260:Female; D011280:Pregnanolone / Q000494:pharmacology; D011460:Prostaglandins F / Q000096:biosynthesis; D011506:Proteins / Q000502:physiology*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism
chemical_list: D011460:Prostaglandins F; D011506:Proteins; D015237:Dinoprost; D011280:Pregnanolone