A demonstration of pharmacokinetics and physiological modelling using a microcomputer for data capture and analysis.
We describe a simple and inexpensive demonstration of mass transport and exchange using dye clearance from a hydrodynamic model. A microcomputer was used for data acquisition and storage, non-linear least squares curve fitting, compartmental analysis and parameter estimation. The system is useful for demonstrating the indicator-dilution technique for fluid volume measurement and compartmental analysis in pharmacokinetics.
Kirkup
L
L
Physics Department, Paisley College of Technology, Scotland.
Nichols
D J
DJ
Sutherland
J
J
D000465:Algorithms; D001692:Biological Transport; D003201:Computers; D008432:Mathematical Computing; D008838:Microcomputers; D008954:Models, Biological; D010599:Pharmacokinetics; D012984:Software