Blood group change in a patient with blastic transformation of a myelodysplastic syndrome.
Loss of certain red blood cell antigens has been described in patients with acute myelocytic leukemia (AML). This paper describes the loss of blood group A antigen in a patient with AML. The acute leukemia in this patient was preceded by a myelodysplastic syndrome for several months. At the time of diagnosis the patient's red cells showed the 0 Rh(D)+ phenotype. After induction of complete remission with two courses of Daunorubicin, Cytosin-arabinosid, and Etoposid his blood group reverted to A2. Serological studies including saliva analysis revealed that the original blood group was very likely A.
Xiros
N
N
Northoff
H
H
Anger
B
B
Heit
W
W
Heimpel
H
H
D000017:ABO Blood-Group System; D000954:Antigens, Surface / Q000032:analysis; D001752:Blast Crisis; D001789:Blood Group Antigens; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000473:pathology; D012074:Remission Induction
D000017:ABO Blood-Group System; D000954:Antigens, Surface; D001789:Blood Group Antigens