title: A new leader exon identified in the rat insulin-like growth factor II gene.
abstract: In the rat insulin-like growth factor II gene, we identified an alternative 5'-untranslated sequence, in addition to the two sequences documented recently (1986) J. Mol. Biol. 192. 737-752, (1986) J. Biol. Chem. 261. 17138-17149. This sequence was encoded in an extreme 5' separate exon (E1 exon), the promoter region of which could be distinguished from others by features including lack of the TATA-box and GC-repeat, and heterogeneity in the transcriptional initiation.
authors.affiliation: Department of Biochemistry, Kyushu University, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ueno
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Matsuguchi
authors.forename: H
authors.initials: H
authors.lastname: Endo
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D004247:DNA / Q000378:metabolism; D005091:Exons; D005796:Genes; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D008114:Liver Neoplasms, Experimental; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D051381:Rats; D013002:Somatomedins / Q000235:genetics*
chemical_list: D013002:Somatomedins; D007335:Insulin-Like Growth Factor II; D004247:DNA