Specific immunity in mice to heartwater.
Mice develop a specific immune response following infection with the mice strains of heartwater. In the case of the Kümm strain the agent can persist in some tissues for up to 365 days. Transfer of spleen cells from immune mice confers protection against homologous challenge in recipient mice showing that cell mediated immunity is important. A comparison with immune mechanisms occurring in other Rickettsia is discussed.
Stewart
S C
SC
Department of Infectious Diseases and Public Health, Faculty of Veterinary Science, Medical University of Southern Africa, Medunsa.
D000818:Animals; D006357:Heartwater Disease / Q000276:immunology*; D007111:Immunity, Cellular; D008264:Macrophages / Q000276:immunology; D051379:Mice / Q000276:immunology*; D012282:Rickettsia Infections / Q000276:immunology