Glucose release by the liver under conditions of reduced activity of glucose 6-phosphatase.
An inhibitor of glucose 6-phosphatase, isosteviol, was used in liver perfusion experiments to obtain a rough estimate of the control strength of the enzyme. Isosteviol only inhibited glucose release at high concentrations (1 mM), well above that needed for half-maximal action (70 microM). The decrease in glucose release was followed by an increase in the intracellular glucose 6-phosphate concentration. It was concluded that the control strength of glucose-6-phosphatase is relatively low.
Ishii
E L
EL
Laboratório de Metabolismo Hepático, Universidade de Maringá, PR, Brasil.
Bracht
A
A
D000818:Animals; D004224:Diterpenes / Q000494:pharmacology*; D045786:Diterpenes, Kaurane; D005947:Glucose / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D010477:Perfusion; D006005:Phosphorylases / Q000378:metabolism; D051381:Rats
D004224:Diterpenes; D045786:Diterpenes, Kaurane; C012042:steviol; D005954:Glucosephosphate Dehydrogenase; D006005:Phosphorylases; D005947:Glucose