Enoxacin-warfarin interaction: pharmacokinetic and stereochemical aspects.
The interaction between the new quinoline-azaquinoline antibiotic enoxacin and the oral anticoagulant warfarin was investigated in six healthy male volunteers. Enoxacin was found not to affect the hypoprothrombinemic response produced by warfarin but did produce a decrease in the clearance of the less pharmacologically potent enantiomer of warfarin, (R)-warfarin. The decreased clearance of (R)-warfarin produced by concomitant enoxacin administration was found to be a consequence of inhibition by enoxacin of the (R)-6-hydroxywarfarin metabolic pathway.
Toon
S
S
Hopkins
K J
KJ
Garstang
F M
FM
Aarons
L
L
Sedman
A
A
Rowland
M
M
D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004347:Drug Interactions; D015365:Enoxacin; D006801:Humans; D007700:Kinetics; D008297:Male; D009287:Naphthyridines / Q000378:metabolism*; D011517:Prothrombin Time; D011897:Random Allocation; D013237:Stereoisomerism; D014859:Warfarin / Q000097:blood / Q000378:metabolism*
D009287:Naphthyridines; D015365:Enoxacin; D014859:Warfarin