title: Algesimetry--a necessity in research on analgesic drugs.
abstract: In addition to the methods of clinical algesimetry, the investigation of the actions of analgesic drugs requires reliable and sensitive methods of experimental algesimetry. In contrast to the clinical investigation of analgesic actions, the methodology of the experimental testing of analgesics in humans is still rudimentary. The difficulties encountered in experimental algesimetry are discussed in this contribution, and an algesimetric study is presented illustrating experimental methods with which the pharmacodynamics of peripherally acting analgesics may be investigated.
authors.forename: H O
authors.initials: HO
authors.lastname: Handwerker
authors.forename: P W
authors.initials: PW
authors.lastname: Reeh
mesh_terms: D000700:Analgesics; D001921:Brain / Q000502:physiology; D006225:Hand / Q000098:blood supply / Q000502:physiology; D006801:Humans; D008564:Membrane Potentials; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000503:physiopathology*
chemical_list: D000700:Analgesics