title: Somatomedin-C/insulin-like growth factor-1 in infants with congenital hypothyroidism during the first week of life.
abstract: Levels of somatomedin-C/insulin-like growth factor-1 (Sm-C/IGF-1) were determined in whole blood collected on filter paper from 41 newborns with congenital hypothyroidism and 183 full-term neonates with normal thyroid function. The mean Sm-C/IGF-1 value of the untreated hypothyroid infants (0.10 U/ml) was virtually identical with that of the normal controls (0.11 U/ml). We are unable to confirm earlier findings of others that Sm-C/IGF-1 concentrations are lower in hypothyroid newborns than in normal infants.
authors.affiliation: Massachusetts Department of Public Health, State Laboratory Institute, Jamaica Plain 02130.
authors.forename: M L
authors.initials: ML
authors.lastname: Mitchell
authors.forename: R J
authors.initials: RJ
authors.lastname: Hermos
authors.forename: A C
authors.initials: AC
authors.lastname: Moses
mesh_terms: D003409:Congenital Hypothyroidism; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood*; D007231:Infant, Newborn / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000097:blood*; D008297:Male; D012016:Reference Values; D013002:Somatomedins / Q000097:blood*; D013997:Time Factors
chemical_list: D013002:Somatomedins; D007334:Insulin-Like Growth Factor I