title: Skeletal changes in broiler chicks and turkey poults fed diets containing ochratoxin A.
abstract: Broiler chicks and turkey poults were divided at hatching into experimental and control groups. Experimental birds were fed a diet contaminated with 4 ppm ochratoxin A, whereas the ration of control birds was confirmed to be mycotoxin free. Birds were killed at fortnightly intervals up to 10 weeks old and skeletal changes were investigated. Almost all experimental birds developed generalised skeletal osteopenia with disturbed endochondral and intramembranous bone formation. Histological changes in diaphyseal cortices could account for the reduced breaking strength of bones from birds fed mycotoxin, which have been reported by others. One bird showed changes consistent with a diagnosis of hypophosphataemic rickets. In others, however, osteoid formation was defective and changes were interpreted as osteoporosis. Although it might be tempting to suggest that osteoporosis is a result of a direct toxic effect of ochratoxin on osteoblasts, the effect of inanition, inactivity and general debility may be equally important.
authors.affiliation: Agricultural and Food Research Council's Poultry Research Centre, Roslin, Midlothian.
authors.forename: S R
authors.initials: SR
authors.lastname: Duff
authors.forename: R B
authors.initials: RB
authors.lastname: Burns
authors.forename: P
authors.initials: P
authors.lastname: Dwivedi
mesh_terms: D000818:Animals; D001846:Bone Development / Q000187:drug effects; D001851:Bone Diseases, Metabolic / Q000139:chemically induced* / Q000473:pathology; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology*; D002645:Chickens / Q000254:growth & development*; D004032:Diet; D005260:Female; D009793:Ochratoxins / Q000633:toxicity*; D014422:Turkeys / Q000254:growth & development*
chemical_list: D009793:Ochratoxins; C025589:ochratoxin A