Transforming growth factor-beta inhibits endothelial cell proliferation.
Transforming growth factor-beta (TGF-beta) is an inhibitor of the proliferation of bovine aortic endothelial cells in culture. Basal cell growth in serum-containing medium and cell proliferation stimulated by fibroblast growth factor (FGF) are inhibited by TGF-beta in a dose-dependent manner. Half-maximal inhibition occurs at an inhibitor concentration of 0.5-1.0 ng/ml. TGF-beta does not appear to be cytotoxic and cells treated with the inhibitor grow normally after removal of TGF-beta. High concentrations of FGF are ineffective in overcoming TGF-beta-induced inhibition of cell proliferation, suggesting that antagonism of growth factor-induced cell proliferation by TGF-beta is of a noncompetitive nature.
Fràter-Schröder
M
M
Müller
G
G
Birchmeier
W
W
Böhlen
P
P
D000818:Animals; D002417:Cattle; D002453:Cell Cycle / Q000187:drug effects; D004727:Endothelium / Q000166:cytology* / Q000187:drug effects; D005346:Fibroblast Growth Factors / Q000037:antagonists & inhibitors; D066298:In Vitro Techniques; D010455:Peptides / Q000494:pharmacology*; D015291:Transforming Growth Factors
D010455:Peptides; D005346:Fibroblast Growth Factors; D015291:Transforming Growth Factors