24-Methyl-23-dehydrocholesterol: a new sterol intermediate in C-24 demethylation from the nematodes Panagrellus redivivus and Caenorhabditis elegans?
Panagrellus redivivus produced 24-methyl-23-dehydrocholesterol as 4.0% of the 4-desmethylsterols when propagated in a medium containing campesterol as the dietary sterol. The re-examination of previous data revealed that Caenorhabditis elegans produced 1.8% 24-methyl-23-dehydrocholesterol when propagated in medium containing campesterol. 24-Methyl-23-dehydrocholesterol was not detected when the nematodes were propagated in medium containing 22-dihydrobrassicasterol or 24-methylenecholesterol. This may be a result of the greater efficiency of dealkylation of the latter two sterols. This is the first report of the natural occurrence of this sterol in a non-photosynthetic organism, and the first report in organisms that dealkylate 24-alkylsterols.
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Department of Botany, University of Maryland, College Park 20742.
Lozano
R
R
Lusby
W R
WR
Chitwood
D J
DJ
Thompson
M J
MJ
D000107:Acetylation; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002775:Cholestadienols / Q000032:analysis*; D002849:Chromatography, Gas; D003640:Dealkylation; D003684:Dehydrocholesterols / Q000032:analysis* / Q000302:isolation & purification; D013058:Mass Spectrometry; D009348:Nematoda / Q000378:metabolism*
D002775:Cholestadienols; D003684:Dehydrocholesterols; C055281:24-methyl-23-dehydrocholesterol