[Experimental study on the development of acute gastric ulcer after hepatectomy in liver cirrhosis--mainly changes in the gastric wall protection mechanism].
Gastric wall blood flow, gastric mucosal noradrenalin (NA), gastric mucosal prostaglandin E2 (PGE2) and gastric mucosal energy metabolism were studied after partial hepatectomy in thioacetamide (TAA) --induced cirrhotic rats and these were also tested by loading water immersion restraint on the 3rd day after partial hepatectomy. Furthermore, the preventive effects of PGE2 on ulcers were also examined. Liver cirrhosis rats were prepared with an abdominal administration of TAA three times a week for 10 weeks, after which 70% partial hepatectomies were performed. The results of these tests showed that the gastric mucosa after partial hepatectomy in liver cirrhosis rats had significantly lower gastric wall blood flow, gastric mucosal NA and gastric mucosal energy and reduced gastric mucosal PGE2. The water immersion restraint stress loaded on the 3rd day to these rats after partial hepatectomy caused a noticeable and an earlier reduction in gastric wall blood flow and gastric mucosal PGE2 than to the normal group, and the ulcer index was high. PGE2 administration also appeared to be effective for the prevention of development of acute ulcers after partial hepatectomy in liver cirrhosis rats.
Takata
T
T
Urakawa
T
T
Saitoh
Y
Y
D000208:Acute Disease; D000818:Animals; D015232:Dinoprostone; D005753:Gastric Mucosa / Q000098:blood supply / Q000473:pathology*; D006498:Hepatectomy; D008106:Liver Cirrhosis, Experimental / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications; D011458:Prostaglandins E / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000209:etiology* / Q000517:prevention & control
D011458:Prostaglandins E; D015232:Dinoprostone