Atropine-antagonized miosis induced in the goat by intravenous infusions of prostaglandin E (PGE1 and PGE2).
Effects of 30 min intravenous infusions of prostaglandin (PG) E1 (total dosage 0.07 mg kg-1), E2 and F2 alpha (total dosage 0.12 mg kg-1), respectively, were studied concomitant with measurements of renal excretion of PGF metabolites in hyperhydrated goats. None of the PGs induced any rise in rectal temperature. However, the PGEs elicited pronounced, atropine-antagonized miosis and an inhibition of the water diuresis accompanied by some increase in renal excretion of arginine vasopressin (AVP). These effects were not obtained in response to PGF2 alpha. The PGF2 alpha rapidly induced a conspicuous and long-lasting increase in the renal excretion of PGF metabolites. The corresponding effect of the PGEs was more delayed, and less than 10% of the increase obtained in response to PGF2 alpha. Nevertheless, the excretion of these metabolites in response to the PGEs was of the same magnitude as that previously observed during endotoxin fever in the goat. It is concluded that endotoxin-induced miosis and stimulation of AVP secretion previously demonstrated in the goat might well have been secondary to systemic PGE production. However, this does not seem to hold true for endotoxin-induced fever.
Jónasson
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H
Basu
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D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D001285:Atropine / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D015237:Dinoprost; D015232:Dinoprostone; D004231:Diuresis / Q000187:drug effects; D005260:Female; D006041:Goats; D007263:Infusions, Parenteral; D007668:Kidney / Q000378:metabolism; D008540:Meiosis / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000378:metabolism / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects; D014867:Water / Q000494:pharmacology
D011458:Prostaglandins E; D011460:Prostaglandins F; D014867:Water; D001127:Arginine Vasopressin; D001285:Atropine; D015237:Dinoprost; D000527:Alprostadil; D015232:Dinoprostone