title: [An unusual way of manifesting acute granulocytic leukemia: granulocytic sarcoma of the breast. Apropos of a case with trisomy 22].
abstract: A case of granulocytic breast sarcoma in a 19 year-old-girl is reported. Surgical excision of the tumor was followed by radiotherapy of the breast and lymph nodes. Then 3 months later acute M2 myelocytic leukemia was diagnosed, complete remission being attained using rubidazone-cytarabine and maintained by monthly reinduction courses. Trisomy of chromosome 22 was present in leukemic cells and disappeared during remission. Its pathogenic significance is briefly discussed.
authors.forename: F
authors.initials: F
authors.lastname: Turpin
authors.forename: M
authors.initials: M
authors.lastname: Trassard
authors.forename: A
authors.initials: A
authors.lastname: Bourguignat
authors.forename: J L
authors.initials: JL
authors.lastname: Floiras
authors.forename: V
authors.initials: V
authors.lastname: Le Doussal
authors.forename: P
authors.initials: P
authors.lastname: Eydoux
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000473:pathology*; D002904:Chromosomes, Human, 21-22 and Y; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D006098:Granulocytes / Q000648:ultrastructure; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics*; D009378:Neoplasms, Multiple Primary; D014314:Trisomy
chemical_list: D003561:Cytarabine; C002205:zorubicin; D003630:Daunorubicin
vernacular_title: Un mode inhabituel de révélation des leucémies aiguës granuleuses: le sarcome granulocytaire du sein. A propos d'un cas porteur d'une trisomie 22.