A new translocation in chronic myeloid leukemia--t(4;9;22)--resulting in a masked Philadelphia chromosome.
A patient with chronic myeloid leukemia is described in whom a novel complex translocation was found among chromosomes #4, #9, and #22, resulting in a "masked" Philadelphia chromosome. The breakpoint in chromosome #4 (band q21) is in the same region as the breakpoint seen in the t(4;11), which is associated with some forms of acute leukemia.
London
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B
Pinkerton
P H
PH
Senn
J S
JS
D000328:Adult; D002904:Chromosomes, Human, 21-22 and Y; D002905:Chromosomes, Human, 4-5; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic