title: A demonstration of pharmacokinetics and physiological modelling using a microcomputer for data capture and analysis.
abstract: We describe a simple and inexpensive demonstration of mass transport and exchange using dye clearance from a hydrodynamic model. A microcomputer was used for data acquisition and storage, non-linear least squares curve fitting, compartmental analysis and parameter estimation. The system is useful for demonstrating the indicator-dilution technique for fluid volume measurement and compartmental analysis in pharmacokinetics.
authors.affiliation: Physics Department, Paisley College of Technology, Scotland.
authors.forename: L
authors.initials: L
authors.lastname: Kirkup
authors.forename: D J
authors.initials: DJ
authors.lastname: Nichols
authors.forename: J
authors.initials: J
authors.lastname: Sutherland
mesh_terms: D000465:Algorithms; D001692:Biological Transport; D003201:Computers; D008432:Mathematical Computing; D008838:Microcomputers; D008954:Models, Biological; D010599:Pharmacokinetics; D012984:Software