[Treatment of Candida urinary tract infections with reference to serum levels of anti-Candida antibody and D-arabinitol].
A clinical study was carried out on 11 patients with Candida urinary tract infection; 4 with chronic cystitis and 7 with acute pyelonephritis including 2 patients associated with candidemia. The patients received 1.5 to 6.0 g of 5-fluorocytosine (5-FC) orally daily for 6 to 22 days. The response was excellent in 6, moderate in 4 and poor in 1 case, overall efficacy rate being 90.9%. No patients showed any adverse reaction. The antibody against the Candida species was measured by an indirect hemagglutination test and the serum level of D-arabinitol, a major metabolite of Candida species, was determined by gas-liquid chromatography. A 4-fold or greater rise in anti-Candida antibody was detected in 4 of the 6 patients with pyelonephritis, including one patient associated with candidemia, 14 to 31 days following the treatment. Serum D-arabinitol levels in all of the 4 patients with pyelonephritis exceeded the detection limit of 0.2 microgram/ml before treatment. The levels decreased promptly during treatment and normalized 10 to 20 days after the start of treatment. These results suggest that 5-FC is an effective drug for Candida urinary tract infections. The determinations of anti-Candida antibody titer and serum D-arabinitol level may be clinically useful for the diagnosis of Candida pyelonephritis. In particular, the serum levels of D-arabinitol appear to be a useful parameter to follow-up the effect of anti-fungal treatment on Candida pyelonephritis.
Tokunaga
S
S
Department of Urology, School of Medicine, Kanazawa University.
Ohkawa
M
M
Hisazumi
H
H
D000328:Adult; D000368:Aged; D000908:Antibodies, Fungal / Q000032:analysis*; D002175:Candida / Q000276:immunology*; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013402:Sugar Alcohols / Q000097:blood*; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000188:drug therapy*
D000908:Antibodies, Fungal; D013402:Sugar Alcohols; D005437:Flucytosine; C014999:arabitol