Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.
The human major histocompatibility complex (MHC) includes the closely linked genes for the tumor necrosis factors alpha and beta. Their location is within the chromosomal segment between HLA-DR and HLA-A or centromeric of HLA-DP. This assignment is based on Southern blot analysis of a number of different MHC deletion mutants and is corroborated by chromosome in situ hybridization.
Spies
T
T
Morton
C C
CC
Nedospasov
S A
SA
Fiers
W
W
Pious
D
D
Strominger
J L
JL
D002872:Chromosome Deletion; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis; D006023:Glycoproteins / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex; D014409:Tumor Necrosis Factor-alpha
D006023:Glycoproteins; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D014409:Tumor Necrosis Factor-alpha; D004247:DNA