Chromosomal changes in relation to tumorigenicity of the murine L1210 leukemia line.
A spontaneous loss of tumorigenicity was observed in long-term in vitro culture of the cell line L1210(VAII), which was derived from mouse lymphoblastic leukemia L1210(V) of DBA/2 mice. The loss of tumorigenicity required at least 12 months of in vitro culture and was accompanied by the appearance of a new karyotypically distinct population. The dominant cell variant of the in vitro population that lost tumorigenicity showed duplication of a fragment within the M2 marker chromosome. The loss of tumorigenicity could be interpreted as a dose effect on tumor growth control by gene(s) localized within this marker chromosome.
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D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D005819:Genetic Markers; D007621:Karyotyping; D007939:Leukemia L1210 / Q000235:genetics* / Q000473:pathology; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation
D005819:Genetic Markers