Anorexia induced in rat by D-glucosamine deoxidized at C-1.
The effects of D-glucosamine (2-amino-2-deoxy-D-glucose), an endogenous glucose analogue, and 1-deoxy-D-glucosamine on feeding behavior were clarified. Test solutions (24 mumol) were infused into the third cerebroventricle of the rat. Glucosamine induced a feeding episode within 30 min after infusion and then prolonged the ensuing postprandial intermeal interval for the first 4 h of the dark period, while glucose suppressed feeding by decreasing meal size. Ventricular injection of 1-deoxyglucosamine potently suppressed feeding in a dose-related manner by affecting all meal parameters, and oral administration of 2,400 mumol also induced anorexia. Changes in activity of glucose-sensitive neurons in the lateral hypothalamus and glucoreceptor neurons in the ventromedial hypothalamus after electrophoretic application of glucosamine and 1-deoxyglucosamine were compatible with behavior changes. The results indicate that replacement of a hydroxyl group by an amino group at C-2 of the glucose molecule affects feeding behavior and deoxidation of C-1 potently induces anorexia.
Fujimoto
K
K
Sakata
T
T
Shiraishi
T
T
Kurata
K
K
Terada
K
K
Etou
H
H
D000284:Administration, Oral; D000818:Animals; D000855:Anorexia / Q000139:chemically induced*; D002552:Cerebral Ventricles / Q000502:physiology; D055598:Chemical Phenomena; D002621:Chemistry; D003624:Darkness; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D001068:Feeding and Eating Disorders / Q000139:chemically induced*; D005944:Glucosamine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D007276:Injections, Intraventricular; D008027:Light; D008124:Locomotion / Q000187:drug effects; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
C047200:1-deoxyglucosamine; D005944:Glucosamine