title: Aspirin, anticoagulants, and hemorrhagic conversion of ischemic infarction: hypothesis and implications.
abstract: Anticoagulation may exacerbate possible tendencies for an ischemic infarction to become hemorrhagic. Little is known of any potential added risk of aspirin plus anticoagulation for such hemorrhagic transformation. A patient is reported who sustained a cerebral infarction from carotid artery disease and was treated with aspirin. Anticoagulation was begun and aspirin discontinued when the patient experienced a transient ischemic attack. Despite good control of anticoagulation, the patient sustained a hemorrhage at the site of infarction. The prolonged effects of aspirin combined with anticoagulants may have potentiated the conversion of an ischemic to a hemorrhagic infarction. Caution is advised when using anticoagulation immediately following aspirin therapy in patients with cerebral infarction.
authors.affiliation: Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.
authors.forename: M
authors.initials: M
authors.lastname: Fisher
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000209:etiology; D002544:Cerebral Infarction / Q000150:complications*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011859:Radiography
chemical_list: D000925:Anticoagulants; D006493:Heparin; D001241:Aspirin