title: [Fibrous dysplasia and ossifying fibroma. Morphologic criteria].
abstract: Among a series of 42 ossifying fibromas and 32 fibrous dysplasias, 5 cases were studied by histoenzymological and electron microscopic methods. The histological study in 2/3 of cases is sufficient for the diagnosis between the two diseases: trabecular bone in a connective tissue with regular collagen fibres in the ossifying fibroma; nodular indented bony areas with irregular collagen frame in fibrous dysplasia. By histoenzymology, the diagnosis between the two affections is not easy: same activity of ATPases and alkaline phosphatases in fibroblasts and osteoblasts. By electron microscopy, the morphology of the two lesions is different: in ossifying fibroma, numerous well-differentiated osteoblasts and large areas of ossification are seen; in fibrous dysplasia, undifferentiated cells are numerous and the collagen frame is irregularly mineralized. This method is also useful for the histogenetic understanding of these two osteopathies.
authors.forename: G
authors.initials: G
authors.lastname: Chomette
authors.forename: M
authors.initials: M
authors.lastname: Auriol
authors.forename: S
authors.initials: S
authors.lastname: Boisnic
authors.forename: F
authors.initials: F
authors.lastname: Guilbert
authors.forename: J M
authors.initials: JM
authors.lastname: Vaillant
mesh_terms: D003094:Collagen; D003937:Diagnosis, Differential; D005147:Facial Bones / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D005347:Fibroblasts / Q000473:pathology / Q000648:ultrastructure; D005350:Fibroma / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D005357:Fibrous Dysplasia of Bone / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D008648:Mesoderm / Q000166:cytology; D010006:Osteoblasts / Q000473:pathology / Q000648:ultrastructure; D010011:Osteocytes / Q000473:pathology / Q000648:ultrastructure; D010016:Osteoma / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D010088:Oxidoreductases / Q000378:metabolism; D012888:Skull Neoplasms / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D003094:Collagen; D010088:Oxidoreductases
vernacular_title: Dysplasie fibreuse et fibrome ossifiant. Critères morphologiques.