The effects of metamizol on prostaglandin synthesis in man.
Clinical pharmacological investigations on the inhibition of prostaglandin synthesis are presented, comparing metamizol and indomethacin with respect to platelet aggregation, platelet thromboxane synthesis, total body PGE2-synthesis and side effects. Prostaglandin synthesis is clearly and persistently inhibited by metamizol in man.
Frölich
J C
JC
Rupp
W A
WA
Zapf
R M
RM
Badian
M J
MJ
D000527:Alprostadil / Q000096:biosynthesis; D000632:Aminopyrine / Q000031:analogs & derivatives*; D001241:Aspirin / Q000494:pharmacology; D003094:Collagen; D015232:Dinoprostone; D004177:Dipyrone / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects; D007700:Kinetics; D010974:Platelet Aggregation / Q000187:drug effects; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis; D013931:Thromboxanes / Q000096:biosynthesis
D011453:Prostaglandins; D011458:Prostaglandins E; D013931:Thromboxanes; D000632:Aminopyrine; D004177:Dipyrone; D003094:Collagen; D000527:Alprostadil; D015232:Dinoprostone; D001241:Aspirin; D007213:Indomethacin