Detection of cardiotoxic hazards.
For the detection and quantitative assessment of cardiovascular toxicity, the morphological and biochemical studies used in routine toxicity tests must be supplemented with functional and metabolic measurements. Examples are given which show that the cardiotoxic effects of allylamine and emetine can be detected early by blood pressure and ECG monitoring. The same techniques are helpful in assessing potential drug interactions. For the hypoglycemic agent MTG measurement of mitochondrial function proved to be the most adequate method to demonstrate cardiotoxic hazard.
Zbinden
G
G
D000499:Allylamine / Q000633:toxicity; D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D009202:Cardiomyopathies / Q000139:chemically induced; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions; D004562:Electrocardiography; D004640:Emetine / Q000633:toxicity; D004852:Epoxy Compounds / Q000633:toxicity; D005260:Female; D006321:Heart / Q000187:drug effects*; D051379:Mice; D011422:Propionates / Q000633:toxicity
D001679:Biogenic Amines; D004852:Epoxy Compounds; D011422:Propionates; D000499:Allylamine; C017522:methyl 2-tetradecylglycidate; D004640:Emetine