Studies on mutagenicity of 3-chloropropylsulfide derivatives, potential antipsoriatic agents.
The mutagenicity of three sulfides--sulfur yperites--was investigated in vitro by a method of chromosome structural aberrations and sister chromatid exchange (SCE) on metaphasic chromosomes of the peripheral blood. The study demonstrated a relatively low mutagenicity of 2-chloroethyl-3-chloropropyl sulfide and permitted initiation of clinical investigation of this compound as a potential antipsoriatic agent.
Strózyński
H
H
Department of Biology, Military Medical Academy, Lódź, Poland.
Strzelczyk
M
M
Scianowski
J
J
D002869:Chromosome Aberrations / Q000187:drug effects; D005663:Furans / Q000633:toxicity*; D006801:Humans; D066298:In Vitro Techniques; D007621:Karyotyping; D007962:Leukocytes / Q000187:drug effects / Q000648:ultrastructure; D009153:Mutagens; D011565:Psoriasis / Q000188:drug therapy*; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013440:Sulfides / Q000633:toxicity*
D005663:Furans; D009153:Mutagens; D013440:Sulfides; C055921:3-chloropropyl-2-furfurylsulfide; C055920:2-chloroethyl-3-chloropropylsulfide