[Relation between molecular structure and the antibacterial activity of N4-substituted sulfanilamides].
With the aim of establishing a correlation between chemical structure and biologic activity of series N, N'-replaced carbamide and thiocarbamide derivatives, containing sulfanilamide group their antibacterial activity has been studied. The microbiologic screening towards eight kinds of gram-positive and gram-negative microorganisms showed that the substitutes in N and N' in the carbamide or thiocarbamide structure influence the force of the effect as well as the kind of microorganisms in which that effect is exhibited. Ascertained was that together with the increase of the number of carbon atoms is strengthen the antibacterial activity (highest in C4) as the derivatives containing aryl radical show higher activity than those containing alkyl radical. The bringing of halogenic atoms in the molecule of the synthesized derivatives increases considerably the antibacterial activity which is expressed mainly in the combinations containing Cl-atom in m-position of the benzene nucleus.
Vŭrbanova
S
S
Danailov
D
D
Kolev
K K
KK
Stefanov
V
V
D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013424:Sulfanilamides / Q000494:pharmacology*; D014508:Urea / Q000031:analogs & derivatives / Q000494:pharmacology
D013424:Sulfanilamides; D014508:Urea
Vrŭzka mezhdu molekulniia stroezh i antibakteriĭnata aktivnost na N4-zamesteni sulfanilamidi.