[Radioprotective effectiveness and toxicity of 4,5-disubstituted tryptamines].
In experiments on mice a study was made of different substituents in the 4th position of the indole ring of 5-methoxytryptamines (5-MOT) on toxicity and radioprotective efficiency of the compounds of this class. It was shown that the administration of the amino-group to a mexamine molecule increased the preparation toxicity; the nitro-group somewhat diminished the toxic properties, and the acetylamino group did not change 5-MOT toxicity. A 5-MOT derivative with a nitro group possessed the strongest radioprotective action. The radioprotective efficiency of these compounds persisted for 1-2 h.
Korovkina
E P
EP
Chernov
G A
GA
Vinograd
L Kh
LKh
Petrunin
I A
IA
Suvorov
N N
NN
D008735:5-Methoxytryptamine / Q000031:analogs & derivatives / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use* / Q000633:toxicity; D013329:Structure-Activity Relationship; D014363:Tryptamines / Q000627:therapeutic use*
D011837:Radiation-Protective Agents; D014363:Tryptamines; D008735:5-Methoxytryptamine
Radiozashchitnaia éffektivnost' i toksichnost' 4,5-dizameshchennykh triptaminov.