title: Effect of intracerebroventricular injection of prostaglandin E2 on anterior pituitary cell proliferation.
abstract: The influence of an intracerebroventricular (i.c.v.) injection of prostaglandin E2 (PGE2) on the mitotic activity of the rat anterior pituitary was investigated. It was found that i.c.v. PGE2 (3 micrograms/20 microliters) resulted in a significant decrease of the mitotic activity in the anterior pituitary. This drop involved mainly chromophobic cells. No mitoses were found in acidophilic cells either in controls or in PGE2-treated rats. It is suggested that PGE2 may release an unidentified hypothalamic factor which inhibits the cell proliferation of the anterior pituitary.
authors.forename: E
authors.initials: E
authors.lastname: Sewerynek
authors.forename: A
authors.initials: A
authors.lastname: Lewiński
authors.forename: J
authors.initials: J
authors.lastname: Konopacki
authors.forename: M
authors.initials: M
authors.lastname: Pawlikowski
authors.forename: M K
authors.initials: MK
authors.lastname: Lewińska
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D015232:Dinoprostone; D007276:Injections, Intraventricular; D008297:Male; D008938:Mitosis / Q000187:drug effects; D010903:Pituitary Gland, Anterior / Q000166:cytology / Q000187:drug effects*; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011458:Prostaglandins E; D015232:Dinoprostone