Disposition of vancomycin in healthy volunteers from oral solution and semi-solid matrix capsules.
Gastrointestinal availability of vancomycin from oral solution and semi-solid matrix capsules was determined in volunteers. The capsule produced faecal, plasma and urine levels of the antibiotic which are similar to those obtained with the solution and offers a viable, convenient oral dosage form.
Lucas
R A
RA
Lilly Research Centre Limited, Windlesham, Surrey, U.K.
Bowtle
W J
WJ
Ryden
R
R
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002214:Capsules; D004304:Dosage Forms; D005069:Evaluation Studies as Topic; D005243:Feces / Q000032:analysis; D006801:Humans; D011092:Polyethylene Glycols; D012996:Solutions; D014640:Vancomycin / Q000008:administration & dosage / Q000493:pharmacokinetics*
D002214:Capsules; D004304:Dosage Forms; D012996:Solutions; D011092:Polyethylene Glycols; D014640:Vancomycin