Inversion (16)(p13q22) in tumor cells of sigmoid colon.
We report on the cytogenetic findings in direct preparations of two tumors of the sigmoid colon. Respectively, they had a near-triploid and a near-tetraploid constitution and relative numerical and other inconstant chromosomal imbalances. The only constant chromosomal structural anomaly apparently was inversion of chromosome #16, inv(16)(p13q22), which was found in all the cells examined. This rearrangement has been found to be associated with a type of acute myelomonocytic leukemia type M4. We suggest that an etiologic clastogenic (and oncogenic) agent responsible for this rearrangement may eventually be the cause of various kinds of malignancy.
Shabtai
F
F
Sternberg
A
A
Klar
D
D
Reiss
R
R
Halbrecht
I
I
D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D002871:Chromosome Banding; D002873:Chromosome Fragility; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D012811:Sigmoid Neoplasms / Q000235:genetics*
D005819:Genetic Markers