Circadian rhythm of free urinary cortisol, temperature and heart rate in endogenous depressives and under antidepressant therapy.
Free cortisol in urine, temperature and heart rate were examined in 81 endogenous depressives and 15 healthy controls in five successive 24-hour rhythms. The nocturnal mean value, amplitude, phase position of the minima and period length were calculated.


RESULTS
cortisol secretion is to be found in larger quantities in depressives than in healthy controls. The amount of cortisol is again raised after a period of sleep deprivation and simultaneously the amplitude becomes larger. Temperature measurements revealed an enlargement of the amplitude following treatment with tricyclic antidepressants. A minimal increase in heart rate is evident in endogenous depressives in comparison with healthy subjects. The heart rate in the entire circadian course is significantly increased by antidepressants. All three variables showed a phase advance of the nocturnal minima in endogenous depression. Alterations in period length could not be detected. The findings were discussed in regard to chronobiological dissertations on endogenous depression.
Goetze
U
U
Klinik für Psychiatrie der Universität Münster, BRD.
Tölle
R
R
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D001833:Body Temperature Regulation / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000652:urine; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006854:Hydrocortisone / Q000652:urine*; D008297:Male; D008875:Middle Aged; D012892:Sleep Deprivation
D000929:Antidepressive Agents, Tricyclic; D006854:Hydrocortisone