title: In vitro effect of trifluoperazine on human lymphocytes.
abstract: Trifluoperazine, a phenothiazine group of tranquilizer was studied for its chromosome damaging effect in human lymphocyte cultures. The cells were treated with 10, 15 and 20 micrograms/culture of trifluoperazine for 24, 48 and 72 hours. A high incidence of chromatid breaks and gaps was observed after 48 and 72 hours treatment. The study revealed that the drug acts mostly on the late S and G2 phase of the cell cycle.
authors.affiliation: Institute of Genetics, Osmania University, Begumpet, Hyderabad, Aandra Pradesh, India.
authors.forename: A
authors.initials: A
authors.lastname: Suryanarayana
authors.forename: P
authors.initials: P
authors.lastname: Rita
authors.forename: P P
authors.initials: PP
authors.lastname: Reddy
mesh_terms: D002842:Chromatids / Q000648:ultrastructure; D002869:Chromosome Aberrations; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects*; D013997:Time Factors; D014268:Trifluoperazine / Q000494:pharmacology*
chemical_list: D014268:Trifluoperazine