Localization of the gene for X-linked spinal muscular atrophy.
We used probes for DNA polymorphisms on the X chromosome to study genetic linkage in seven families with X-linked adult-onset spinal muscular atrophy. We found significant linkage to the marker DXYS1 on the proximal X chromosome long arm and loose linkage or nonlinkage to markers elsewhere. Our analysis localizes the gene defect for this form of anterior horn cell disease.
Fischbeck
K H
KH
Ionasescu
V
V
Ritter
A W
AW
Ionasescu
R
R
Davies
K
K
Ball
S
S
Bosch
P
P
Burns
T
T
Hausmanowa-Petrusewicz
I
I
Borkowska
J
J
D000328:Adult; D000368:Aged; D004247:DNA; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009136:Muscular Dystrophies / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010375:Pedigree; D011110:Polymorphism, Genetic; D014960:X Chromosome
D005819:Genetic Markers; D004247:DNA