Genetics of susceptibility to oral tolerance to ovalbumin.
Inbred mouse strains vary widely in their susceptibility to the induction of tolerance following oral (intragastric) administration of ovalbumin. Marked differences were found between strains that form a congenic pair differing at the H-2 complex: C3H/HeJ (H-2k) and C3H.SW (H-2b)-which were very susceptible and resistant to tolerance induction, respectively. In contrast, no significant differences were found between A/J (H-2a) and A.BY (H-2b) congenics, which were both susceptible, nor among C57BL/10J congenics, which were uniformly resistant to tolerance induction. We conclude that H-2-linked genes determine tolerance susceptibility in conjunction with background genes.
Vaz
N M
NM
Departamento de Bioquímica-Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Rios
M J
MJ
Lopes
L M
LM
Gontijo
C M
CM
Castanheira
E B
EB
Jacquemart
F
F
Andrade
L A
LA
D000284:Administration, Oral; D000818:Animals; D004361:Drug Tolerance; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006183:H-2 Antigens / Q000235:genetics*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000378:metabolism; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008814:Mice, Inbred NZB; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology* / Q000378:metabolism; D013045:Species Specificity
D006183:H-2 Antigens; D010047:Ovalbumin