title: Acute myelomonocytic leukemia with double minute chromosomes and a normal karyotype.
abstract: A case of acute myelomonocytic leukemia in a 74-year-old male patient is described whose bone marrow cells had a normal male karyotype but with double minutes chromosomes (DM). The patient had no history of exposure to mutagenic or carcinogenic agents, or a history of other malignancies. The clinical and etiologic implications of DM as a sole karyotypic anomaly in the leukemic cells are discussed.
authors.forename: J H
authors.initials: JH
authors.lastname: Ohyashiki
authors.forename: K
authors.initials: K
authors.lastname: Ohyashiki
authors.forename: K B
authors.initials: KB
authors.lastname: Miller
authors.forename: B P
authors.initials: BP
authors.lastname: Cuiffo
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002882:Chromosomes, Human, Pair 13; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male