title: Clinical and experimental observations on resinifying therapy.
abstract: The principles, indications, and techniques of resinifying therapy and the composition of a resinifying agent are described in this article. The permeability and bacteriostasis of the agent and the volume change of the agent after treatment were observed, and 14C-labeled phenoaldehyde showed that the agent not only filled the main canals and accessory canals but also infiltrated into dentinal tubules with a depth one fourth to one third the total length of the tubules. The antimicrobial activity of the agent after polymerization for 2 to 6 months was determined. Even 9 months after treatment, no change in volume of the agent was found in vivo, and sealing of canals was maintained. Seventy-eight teeth in 69 patients with pulpoperiapical diseases were subjected to resinifying therapy and followed up for 6 to 12 months; the success rate was 82.05%. The histologic study indicated that, of the specimens experimentally treated for 6 to 12 months, 85.7% showed mild or no inflammation while 53.6% showed complete healing or an obvious healing tendency. Furthermore, the mechanisms and advantages of this therapy are discussed.
authors.forename: M K
authors.initials: MK
authors.lastname: Wu
authors.forename: M E
authors.initials: ME
authors.lastname: Wang
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects; D003408:Cresols / Q000494:pharmacology; D003788:Dental Pulp Diseases / Q000473:pathology / Q000628:therapy; D004285:Dogs; D004338:Drug Combinations / Q000494:pharmacology; D005500:Follow-Up Studies; D005557:Formaldehyde / Q000494:pharmacology; D006801:Humans; D007202:Indicators and Reagents; D012117:Resins, Synthetic; D012118:Resorcinols / Q000494:pharmacology; D012387:Root Canal Filling Materials / Q000494:pharmacology; D012390:Root Canal Therapy / Q000379:methods*; D014088:Tooth Permeability / Q000187:drug effects; D014092:Tooth Root / Q000473:pathology
chemical_list: D003408:Cresols; D004338:Drug Combinations; D007202:Indicators and Reagents; D012117:Resins, Synthetic; D012118:Resorcinols; D012387:Root Canal Filling Materials; D005557:Formaldehyde; C050719:phenoaldehyde