title: [Radioprotective effectiveness and toxicity of 4,5-disubstituted tryptamines].
abstract: In experiments on mice a study was made of different substituents in the 4th position of the indole ring of 5-methoxytryptamines (5-MOT) on toxicity and radioprotective efficiency of the compounds of this class. It was shown that the administration of the amino-group to a mexamine molecule increased the preparation toxicity; the nitro-group somewhat diminished the toxic properties, and the acetylamino group did not change 5-MOT toxicity. A 5-MOT derivative with a nitro group possessed the strongest radioprotective action. The radioprotective efficiency of these compounds persisted for 1-2 h.
authors.forename: E P
authors.initials: EP
authors.lastname: Korovkina
authors.forename: G A
authors.initials: GA
authors.lastname: Chernov
authors.forename: L Kh
authors.initials: LKh
authors.lastname: Vinograd
authors.forename: I A
authors.initials: IA
authors.lastname: Petrunin
authors.forename: N N
authors.initials: NN
authors.lastname: Suvorov
mesh_terms: D008735:5-Methoxytryptamine / Q000031:analogs & derivatives / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use* / Q000633:toxicity; D013329:Structure-Activity Relationship; D014363:Tryptamines / Q000627:therapeutic use*
chemical_list: D011837:Radiation-Protective Agents; D014363:Tryptamines; D008735:5-Methoxytryptamine
vernacular_title: Radiozashchitnaia éffektivnost' i toksichnost' 4,5-dizameshchennykh triptaminov.