title: A modified Chou and Fasman protein structure algorithm.
abstract: A FORTRAN program PRSTRC has been developed for protein secondary structure prediction, which is a modified Chou and Fasman (1978) analysis. This implementation carries out a running average of amino acid structure occurrence frequencies, utilizes a simple set of nucleation conditions, and allows user control over nucleation threshold and cutoff parameters. The algorithm includes prediction of the newly defined secondary structure elements: omega loops (1986). It also generates a charge distribution and hydropathy profile. Output includes a simple graphic display for a printer, or a CRT using color addition. Correct structures are predicted for T. dyscritum hemerythrin and the variable domain of mouse immunoglobin k-chain.
authors.affiliation: MBCRR, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, MA 02115.
authors.forename: W W
authors.initials: WW
authors.lastname: Ralph
authors.forename: T
authors.initials: T
authors.lastname: Webster
authors.forename: T F
authors.initials: TF
authors.lastname: Smith
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D011487:Protein Conformation; D012984:Software; D012985:Software Design