Brown adipose tissue is a target tissue in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced toxicity.
This paper demonstrates by electron microscopy that interscapular brown adipose tissue (IBAT) is a target tissue of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rats. Because of the known importance of IBAT in energy metabolism, it is suggested that brown adipose tissue may be a major target tissue in the toxicity of TCDD.
Rozman
K
K
Strassle
B
B
Iatropoulos
M J
MJ
D000064:Acclimatization; D002001:Adipose Tissue, Brown / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D000818:Animals; D003080:Cold Temperature; D004147:Dioxins / Q000633:toxicity*; D008297:Male; D008854:Microscopy, Electron; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins