[Effect of bunazosin on lower urinary tract function in the decerebrated dog].
The effect of bunazosin on the lower urinary tract function was studied by combined recording of cystometry and sphincter electromyogram (EMG) in 8 decerebrated dogs. Micturitions were induced by bladder filling and microelectrical stimulation of the pons before and after the administration of bunazosin. Bunazosin (0.03 mg/kg, i.v.) produced overflow incontinence in 7 of the 8 dogs and a significant decrease in the contractile response pressure to microelectrical stimulation of the pons in 6 dogs. Bunazosin appears to produce a decrease in urethral resistance and to be useful for the treatment of the failure of bladder emptying due to high urethral resistance.
Nishizawa
O
O
Department of Urology, Akita University School of Medicine.
Noto
H
H
Ebina
K
K
Nakamura
H
H
Fukuda
T
T
Suzuki
K
K
Tsuchida
S
S
D000818:Animals; D003655:Decerebrate State; D004285:Dogs; D004558:Electric Stimulation; D004576:Electromyography; D011149:Pons; D011799:Quinazolines / Q000494:pharmacology*; D014521:Urethra / Q000187:drug effects* / Q000503:physiopathology; D001743:Urinary Bladder / Q000187:drug effects* / Q000503:physiopathology
D011799:Quinazolines; C018176:bunazosin