[Effect of cancer chemotherapeutic agents on induction of differentiation of cells and their therapeutic implications].
Experimental evidences were presented to show induction by cancer chemotherapeutic agents of terminal differentiation of several cultured myeloid leukemia cell lines and fresh leukemia cells from patients with myelogenous leukemia. A description was also given of recent clinical trials to improve the therapy of patients with refractory acute myelogenous leukemia by administration of small doses of cancer chemotherapeutic agents resulting in enhanced populations of mature granulocytes in the peripheral blood of patients. These cancer chemotherapeutic agents are suggested to induce differentiation of several cultured leukemia cell lines both in vitro and in vivo by mechanisms distinct from those of their cytotoxic actions. Based on these findings, possible therapeutic implications of the differentiation-stimulating actions of the cancer chemotherapeutic agents on host response-modifying actions are discussed.
Hozumi
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D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D013268:Stimulation, Chemical
D000970:Antineoplastic Agents