title: Hematogenous origin of brain macrophages: a case report.
abstract: Del Río-Hortega believed that phagocytic cells in the CNS arise from microglia; however, recent autoradiographic studies have suggested a hematogenous origin for brain macrophages. To clarify this issue, we studied a young man with acute lymphoblastic leukemia and a peripheral white blood cell count of 22/mm3 who had an embolic brain infarct 2 weeks before he died. Macrophages were scarce within the lesion, suggesting that the principal phagocytic cell is hematogenous.
authors.forename: M F
authors.initials: MF
authors.lastname: Casanova
authors.forename: J C
authors.initials: JC
authors.lastname: Troncoso
authors.forename: D L
authors.initials: DL
authors.lastname: Price
mesh_terms: D000293:Adolescent; D002544:Cerebral Infarction / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology* / Q000503:physiopathology; D008264:Macrophages / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D010296:Parietal Lobe / Q000473:pathology; D013702:Temporal Lobe / Q000473:pathology