Effect of imidazoquinazolinones on tumor cells in the circulation.
Of several imidazoquinazolinones, Anagrelide was found to be the most effective compound to inhibit platelet aggregation and to increase circulation time of intravenously injected tumor cells resulting in metastasis formation.
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D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009360:Neoplastic Cells, Circulating; D010974:Platelet Aggregation / Q000187:drug effects; D011799:Quinazolines / Q000494:pharmacology*
D000970:Antineoplastic Agents; D005343:Fibrinolytic Agents; D011799:Quinazolines; C021139:anagrelide