Late appearing 5q--marker in refractory anemia.
A patient with myelodysplasia indistinguishable from the 5q--syndrome is described. No clonal chromosome abnormalities were detected in the total of 120 bone marrow cells initially examined. At the next sampling, 3 years later, del(5q) was present in all analyzed metaphases. These findings indicate that del(5q) may be only one of the pathogenetically important events in the 5q--syndrome, and that submicroscopic changes may precede the visible chromosomal rearrangement.
Heim
S
S
Billström
R
R
Kristoffersson
U
U
Mandahl
N
N
Mitelman
F
F
D000753:Anemia, Refractory / Q000235:genetics*; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D013997:Time Factors
D005819:Genetic Markers