Synthesis of 3 beta-hydroxy-5 alpha-cholest-8-en-7-one and 3 beta-hydroxy-5 alpha-cholest-8-en-11-one: evaluation as potential hypocholesterolemic agents.
An efficient procedure for the chemical synthesis of 3 beta-hydroxy-5 alpha-cholest-8-en-7-one and 3 beta-hydroxy-5 alpha-cholest-8-en-11-one is described. These ketosterols have been shown to have possible significant hypocholesterolemic effects when fed to normal rats at a level of 0.15% in a laboratory chow diet. The diets containing the steroids caused significant decreases in food consumption which were associated with decreases in the rate of gain in body weight.
Parish
E J
EJ
Department of Chemistry, Auburn University, Alabama 36849-3501.
Nanduri
V B
VB
Seikel
J M
JM
Kohl
H H
HH
Nusbaum
K E
KE
D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002782:Cholestenes / Q000138:chemical synthesis*; D002783:Cholestenones / Q000138:chemical synthesis* / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D004032:Diet; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000924:Anticholesteremic Agents; D002782:Cholestenes; D002783:Cholestenones; C055279:3-hydroxycholest-8-en-11-one; C055276:3-hydroxycholest-8-en-7-one; D002784:Cholesterol