Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22.
In order to determine on which chromosome the gene controlling human cytochrome P-450 (debrisoquine/sparteine type) is located a linkage study of polymorphic sparteine oxidation (PSO) to various polymorphic markers was carried out. Positive information for linkage between PSO and the P1 blood group was obtained with a maximal LOD-score of LOD = 3.35 for both male and female recombination fraction estimates of theta m = theta f = 0.0. The P1 blood group has been recently mapped to the long arm of chromosome 22. Thus it can be concluded that the gene controlling human cytochrome P-450 (debrisoquine/sparteine) is situated on the long arm of chromosome 22 in close vicinity to P1.
Eichelbaum
M
M
Baur
M P
MP
Dengler
H J
HJ
Osikowska-Evers
B O
BO
Tieves
G
G
Zekorn
C
C
Rittner
C
C
D000483:Alleles; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D003647:Debrisoquin / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010127:P Blood-Group System / Q000235:genetics; D013034:Sparteine / Q000378:metabolism
D005819:Genetic Markers; D010127:P Blood-Group System; D013034:Sparteine; D003577:Cytochrome P-450 Enzyme System; D003647:Debrisoquin