title: [Action of T-activin on human natural killer activity in vitro].
abstract: The activity of natural killers (NK) from human peripheral blood was determined by 3H-uridine test using target cells K-562. T-activin effect on the activity of human NK in vitro depended on two parameters: the preparation dose and effector/target cells ratio. The inhibitory effect of T-activin was observed with high doses and increased E/T ratio, while the activating effect was noted with low doses and reduced E/T ratio. This can be attributed to the heterogeneity of NK population, different functional role of high and low doses of thymic factors and the development of NK as T-cell precursors.
authors.forename: S B
authors.initials: SB
authors.lastname: Cheknev
authors.forename: M Z
authors.initials: MZ
authors.lastname: Saidov
authors.forename: L V
authors.initials: LV
authors.lastname: Koval'chuk
authors.forename: A S
authors.initials: AS
authors.lastname: Pavliuk
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Arion
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D007951:Leukemia, Myeloid / Q000276:immunology; D008875:Middle Aged; D010455:Peptides / Q000494:pharmacology*; D013949:Thymus Extracts / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
vernacular_title: Deĭstvie T-aktivina na aktivnost' estestvennykh killerov cheloveka invitro.