title: The effect of cytosine-arabinoside treatment on the overexpression of c-myc protooncogene in a case of prolymphocytic leukemia.
abstract: An unusually high level of expression of the c-myc protooncogene was observed in peripheral blood lymphocytes of a patient with prolymphocytic leukemia (atypical chronic lymphocytic leukemia). The overexpression of c-myc could not be attributed to a high level of proliferating activity of the leukemic cells in the blood. Treatment with cytosine-arabinoside at high doses abolished this altered expression of c-myc and resulted in a twofold increase in the expression of a gene sequence encoding the invariant gamma-chain of class II histocompatibility antigens, preferentially expressed in resting B lymphocytes. These observations suggest that the leukemic cells may have been arrested in the cell cycle outside the G0 phase. Our findings demonstrate that growth-regulated genes can be useful molecular markers of diseases with altered mechanisms of cellular proliferation.
authors.forename: L
authors.initials: L
authors.lastname: Kaczmarek
authors.forename: I B
authors.initials: IB
authors.lastname: Elfenbein
authors.forename: F
authors.initials: F
authors.lastname: Narni
authors.forename: E C
authors.initials: EC
authors.lastname: Vonderheid
authors.forename: W E
authors.initials: WE
authors.lastname: Barry
authors.forename: B
authors.initials: B
authors.lastname: Calabretta
mesh_terms: D002455:Cell Division / Q000187:drug effects; D003561:Cytarabine / Q000627:therapeutic use*; D004273:DNA, Neoplasm / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects; D005819:Genetic Markers; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes
chemical_list: D004273:DNA, Neoplasm; D005819:Genetic Markers; D003561:Cytarabine