title: The value of case reports in human teratology.
abstract: Birth defects caused by human teratogens are an important and potentially preventable cause of perinatal morbidity and mortality. Case reports provide an initial suggestion that a specific agent may be a human teratogen and provide the basis for further study. This review discusses the importance of case reports in human teratology and provides guidance in evaluating new case reports.
authors.forename: J D
authors.initials: JD
authors.lastname: Goldberg
authors.forename: M S
authors.initials: MS
authors.lastname: Golbus
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology / Q000209:etiology; D000818:Animals; D000932:Antiemetics / Q000009:adverse effects; D004025:Dicyclomine; D004319:Doxylamine / Q000009:adverse effects; D004338:Drug Combinations / Q000009:adverse effects; D004917:Erythromycin / Q000009:adverse effects; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015474:Isotretinoin; D008499:Medical Records; D011247:Pregnancy; D011643:Publishing; D011736:Pyridoxine / Q000009:adverse effects; D013723:Teratogens; D013792:Thalidomide / Q000009:adverse effects; D014212:Tretinoin / Q000009:adverse effects; D014859:Warfarin / Q000009:adverse effects
chemical_list: D000932:Antiemetics; D004338:Drug Combinations; D013723:Teratogens; C004454:dicyclomine, doxylamine, pyridoxine drug combination; D004025:Dicyclomine; D013792:Thalidomide; D014212:Tretinoin; D014859:Warfarin; D004917:Erythromycin; D004319:Doxylamine; D015474:Isotretinoin; D011736:Pyridoxine