A study of the prostaglandin and thromboxane content of the central nervous tissues with the development of chronic relapsing allergic encephalomyelitis.
Levels of PGE, PGF2 alpha, 6-oxo-PGF1 alpha and thromboxane (TXB2) in spinal cords and cerebellums of guinea pigs at different stages of chronic relapsing allergic encephalomyelitis (CREAE) were compared with those in Freund's adjuvant-treated, age-matched controls. PGE and TXB2 levels were found to be increased in spinal cords during acute and relapse phases of the disease. The number of lesions in the spinal cord was similarly increased in acute and relapse stages. There was, however, no similar correlation between number of lesions and eicosanoid levels in the cerebellum with the clinical stages of the disease based on hind limb paralysis. In the acute phase and remission lesion numbers were low, and high levels, similar to those found in the spinal cord, were only found in the relapse phase. Eicosanoid levels were high in the acute phase and remission, and generally low in relapse. The spinal cord levels of eicosanoids in remission and relapse correlated well with previous data obtained from the CSF of patients with multiple sclerosis.
Bolton
C
C
Parker
D
D
McLeod
J
J
Turk
J L
JL
D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis; D000818:Animals; D002490:Central Nervous System / Q000032:analysis*; D002531:Cerebellum / Q000032:analysis; D015237:Dinoprost; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism*; D006168:Guinea Pigs; D006801:Humans; D009103:Multiple Sclerosis / Q000378:metabolism; D011453:Prostaglandins / Q000032:analysis*; D011458:Prostaglandins E / Q000032:analysis; D011460:Prostaglandins F / Q000032:analysis; D013116:Spinal Cord / Q000032:analysis; D013929:Thromboxane B2 / Q000032:analysis*
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D015237:Dinoprost