[Relation of the signs of malignant degeneration and tumor cell reaction to a growth-stimulating factor].
Six clones of mouse sarcoma induced by subcutaneous implantation of a plastic film were studied. They differed in the degree of production of the transforming growth factor (TGF) and in stimulation of proliferation in semi-solid medium. The degree of cancerogenicity and cloning efficiency in semi-solid medium correlated with the reactivity of cells to TGF.
Dugina
V B
VB
Stavrovskaia
A A
AA
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000378:metabolism; D002999:Clone Cells / Q000187:drug effects / Q000502:physiology; D006133:Growth Substances / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D009363:Neoplasm Proteins / Q000378:metabolism / Q000494:pharmacology*; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology*; D012513:Sarcoma, Experimental / Q000378:metabolism / Q000473:pathology*; D015291:Transforming Growth Factors
D006133:Growth Substances; D009363:Neoplasm Proteins; D010455:Peptides; D015291:Transforming Growth Factors
Sviaz' priznakov malignizatsii i reaktsii opukholevykh kletok na roststimuliruiushchiĭ faktor.