title: Effects of high-calcium and/or high-sodium diet on basal and angiotensin II-stimulated blood pressure in the spontaneously hypertensive rat.
abstract: Direct conscious blood pressure (BP) was measured via indwelling femoral cannula to evaluate the effects of chronic diet supplements with Na, Ca or both, offered to 3-week-old weanling spontaneously hypertensive rats (SHR). Despite similar food intakes, body weights were reduced within 1-2 weeks on high-Ca diets. Blood pressure was unchanged by 5.5 weeks of diet treatments. However, irrespective of concomitant Na supplement, more prolonged treatment with the high-Ca diet completely abolished the further increase in BP between the 9th and 12th weeks of age, which was noted in the rats fed the normal or high-Na diets. Angiotensin-stimulated BP was attenuated by high-Ca diets regardless of diet Na, similar to basal readings. These weight and pressure effects of Ca were not reproduced by high-Na diet alone. For all four groups, BP was directly and significantly correlated with body weight, both at 9 and 12 weeks of age. These studies demonstrate the potential role of growth retardation in the antihypertensive action of oral Ca loading in young rats.
authors.forename: K
authors.initials: K
authors.lastname: Lau
authors.forename: D
authors.initials: D
authors.lastname: Thomas
authors.forename: D
authors.initials: D
authors.lastname: Salvi
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: S
authors.initials: S
authors.lastname: Tan
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002136:Calcium, Dietary / Q000008:administration & dosage*; D005260:Female; D006973:Hypertension / Q000178:diet therapy* / Q000235:genetics; D051381:Rats; D011918:Rats, Inbred SHR; D012965:Sodium Chloride / Q000008:administration & dosage*
chemical_list: D002136:Calcium, Dietary; D000804:Angiotensin II; D012965:Sodium Chloride