The influence of clenbuterol on prostaglandin F2 alpha-induced dyspnoea in calves.
Pulmonary function tests were performed in six healthy calves. Prostaglandin F2 alpha causes severe narrowing of both upper and lower airways (total lung resistance increased, dynamic compliance decreased). Clenbuterol administered intravenously fifteen minutes prior to prostaglandin F2 alpha aerosol, and in increasing doses (0, 0.4, 0.8, 1.2 micrograms/kg), on days 1, 2, 4 and 6 of the experiment, effectively but not entirely suppressed these responses. These data indicate that beta-adrenergic receptors are present in the bovine airways and that the use of clenbuterol (0.8 micrograms/kg) may be effective in treating clinical respiratory disease such as bronchopneumonia in calves.
Nuytten
J
J
Muylle
E
E
Oyaert
W
W
Van den Hende
C
C
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced*; D002976:Clenbuterol / Q000494:pharmacology*; D015237:Dinoprost; D004417:Dyspnea / Q000139:chemically induced / Q000662:veterinary*; D004983:Ethanolamines / Q000494:pharmacology*; D011460:Prostaglandins F / Q000633:toxicity*; D012119:Respiration / Q000187:drug effects*; D012129:Respiratory Function Tests / Q000662:veterinary
D004983:Ethanolamines; D011460:Prostaglandins F; D015237:Dinoprost; D002976:Clenbuterol