title: Carnitine and experimental carbohydrate-induced hyperlipoproteinemia.
abstract: Carnitine, beta-hydroxy-gamma-trimethylaminobutyrate, plays an important role as a factor necessary for the transport of long-chain fatty acids into the mitochondria. In order to investigate the influence of L(--)-carnitine on hyperlipoproteinemias, the experimental model of the sucrose-induced hypertriglyceridemia of the rat was used. In these experiments L(--)-carnitine in the dose of 11 mg per day and 100 g body weight was able to antagonize the sucrose-induced hypertriglyceridemia and the increase of serum-free fatty acid level in female rats of the Wistar strain. Carnitine administration did not change the activities of lipogenic liver enzymes and the activity of post-heparin lipase. On the other hand, carnitine administration increased the rate of fatty acid oxidation in the liver. The main result of the study, i.e. the lipid-lowering effect of L-carnitine, suggests the use of this compound in the therapy of hyperlipoproteinemias.
authors.affiliation: Institute of Clinical Chemistry and Laboratory Diagnostic, Medical Faculty, Karl-Marx-University, Leipzig, G.D.R.
authors.forename: V
authors.initials: V
authors.lastname: Richter
authors.forename: F
authors.initials: F
authors.lastname: Rassoul
authors.forename: G
authors.initials: G
authors.lastname: Schulz
authors.forename: W D
authors.initials: WD
authors.lastname: Sittner
authors.forename: H
authors.initials: H
authors.lastname: Seim
authors.forename: H
authors.initials: H
authors.lastname: Löster
authors.forename: W
authors.initials: W
authors.lastname: Rotzsch
mesh_terms: D000818:Animals; D002331:Carnitine / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D004040:Dietary Carbohydrates; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006951:Hyperlipoproteinemias / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013395:Sucrose; D014280:Triglycerides / Q000097:blood*
chemical_list: D004040:Dietary Carbohydrates; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D013395:Sucrose; D002784:Cholesterol; D002331:Carnitine