[Analysis of the organization of background activity of the septal neurons of the guinea pig in vitro].
Activity of medial septum-diagonal band neurons (MS-DB-neurons) was investigated extracellularly in slices of the guinea pig septum. Four groups of units were differentiated on the basis of pattern of discharges and coefficient of variation (CV) of interspike intervals: highly regular (CV less than 0.3); regular (CV greater than 0.3 less than 0.7); irregular (CV greater than 0.7); and rhythmically bursting group. Activity of the 1st group was highly resistant to superfusion of medium with low Ca2+, high Mg2+ (or Co2+) concentration, while synaptic effects were blocked under this condition. The same was true for some cells with rhythmic bursts. The activity of Mg2+-resistant rhythmically bursting cells did not change its pattern also under the influence of GABA- and acetylcholine antagonists. It is concluded that the MS-DB contains units with properties of regular and bursting endogenous pacemakers.
Vinogradova
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OS
Zhadina
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SD
Brazhnik
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ES
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002478:Cells, Cultured; D003864:Depression, Chemical; D018756:GABA Antagonists; D006168:Guinea Pigs; D008274:Magnesium / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D012601:Scopolamine / Q000494:pharmacology; D012686:Septal Nuclei / Q000187:drug effects / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology
D018756:GABA Antagonists; D001285:Atropine; D012601:Scopolamine; D008274:Magnesium; D000109:Acetylcholine; D002118:Calcium; D001640:Bicuculline
Analiz organizatsii fonovoĭ aktivnosti septal'nykh neĭronov mokskoĭ svinki in vitro.