Microbial transformation of azacarbazoles. V. Studies on N-1 methylation of 4-methyl-alpha-carboline by Kitasatosporia setae strain.
N-1 methylation of an azacarbazole, 4-methyl-alpha-carboline by Kitasatosporia setae was associated with antifungal metabolite production. Incubation of 4-methyl-alpha-carboline with intact cells or homogenates of Kitasatosporia setae and L-/14CH3/-methionine or adenosyl-S-/14CH3/-L-methionine yielded radioactive products, 1,4-dimethyl-alpha-iso-carboline. The presence of 14C-labelled methyl groups in antifungal metabolite has been also observed. Mutants of Kitasatosporia setae with lost abilities to produce antifungal metabolite did not convert 4-methyl-alpha-carboline into its methyl derivative.
Peczyńska-Czoch
W
W
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
D000192:Actinomycetales / Q000378:metabolism*; D000935:Antifungal Agents / Q000378:metabolism; D001711:Biotransformation; D002243:Carbolines / Q000493:pharmacokinetics*; D008745:Methylation
D000935:Antifungal Agents; D002243:Carbolines; C055574:4-methyl-alpha-carboline