title: Cutaneous leishmaniasis in Bolivia. A study of 185 human cases from Alto Beni (La Paz Department). Isolation and isoenzyme characterization of 26 strains of Leishmania braziliensis braziliensis [corrected].
abstract: A clinical, serological, parasitological and therapeutic study of cutaneous leishmaniasis was carried out in a low sub-andean area (250-800 metres) of the La Paz Department, Bolivia. A team of seismic prospectors (350 workers) was surveyed for 12 months. Of 200 suspected cases of cutaneous leishmaniasis, 185 were serologically or parasitologically confirmed (incidence 52.8%). Those exposed to the greatest risk of infection were working in a virgin forest environment. Leishmanial organisms were isolated from 26 of the workers, either by in vitro cultivation or inoculation into hamsters. Isoenzyme characterization of the organisms by cellulose acetate electrophoresis showed them to be Leishmania braziliensis braziliensis [corrected]. The results of treatment of 168 patients with a pentavalent antimonial drug are also reported.
authors.affiliation: Institut Pasteur-IBBA, Embajada de Francia, La Paz, Bolivia.
authors.forename: P
authors.initials: P
authors.lastname: Desjeux
authors.forename: S
authors.initials: S
authors.lastname: Mollinedo
authors.forename: F
authors.initials: F
authors.lastname: Le Pont
authors.forename: A
authors.initials: A
authors.lastname: Paredes
authors.forename: G
authors.initials: G
authors.lastname: Ugarte
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D001838:Bolivia; D006224:Cricetinae; D006801:Humans; D007891:Leishmania / Q000302:isolation & purification*; D007892:Leishmania braziliensis / Q000145:classification / Q000302:isolation & purification*; D007896:Leishmaniasis / Q000188:drug therapy / Q000453:epidemiology / Q000469:parasitology*; D008536:Meglumine / Q000627:therapeutic use; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000627:therapeutic use; D012867:Skin / Q000469:parasitology
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate