title: Effect of nicotine chewing gum on salivary secretion.
abstract: The effect of nicotine, placebo for nicotine or menthol-tasting chewing gums on salivation was studied in 25 healthy volunteers. The chewing of a commercial nicotine containing (2 mg) chewing gum (Nicorette) did not give a larger rate of salivation than did the chewing of a placebo chewing gum. For both types of chewing gums the rate of salivation was highest during the initial 5 min and it decreased thereafter. Menthol-tasting chewing gum gave a significantly higher amount of stimulated saliva. It is concluded that the addition of nicotine to a chewing gum does not provide an additional stimulus for salivation.
authors.forename: M
authors.initials: M
authors.lastname: Dunér-Engström
authors.forename: O
authors.initials: O
authors.lastname: Larsson
authors.forename: J
authors.initials: J
authors.lastname: Lundberg
authors.forename: B B
authors.initials: BB
authors.lastname: Fredholm
mesh_terms: D000328:Adult; D002638:Chewing Gum; D005260:Female; D006801:Humans; D008297:Male; D008610:Menthol / Q000494:pharmacology; D009538:Nicotine / Q000494:pharmacology*; D010919:Placebos; D012463:Saliva / Q000187:drug effects / Q000378:metabolism*; D012472:Salivation / Q000187:drug effects; D013997:Time Factors
chemical_list: D002638:Chewing Gum; D010919:Placebos; D008610:Menthol; D009538:Nicotine