7,8-Benzoflavone: an inhibitor of prostaglandin synthesis and ornithine decarboxylase in murine epidermal cultures.
7,8-Benzoflavone (7,8-BF), over a dose range of 0.1-10 microM, partially inhibited the synthesis of prostaglandin E2 (PGE2) in primary cultures of epidermal cells from SENCAR mice, and completely suppressed the TPA-dependent stimulation of PGE2 synthesis. Under identical conditions 7,8-BF also partially suppressed ornithine decarboxylase (ODC) activity in both unstimulated and TPA stimulated cultures. The finding that 7,8-BF inhibition of TPA-induced ODC can not be overcome by addition of exogenous PGE2 suggests that ODC induction by TPA involves a prostaglandin-independent component.
Fischer
S M
SM
Reiners
J J
JJ
D000818:Animals; D001571:Benzoflavones / Q000494:pharmacology*; D002478:Cells, Cultured; D015232:Dinoprostone; D005419:Flavonoids / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D065108:Ornithine Decarboxylase Inhibitors; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D001571:Benzoflavones; D005419:Flavonoids; D065108:Ornithine Decarboxylase Inhibitors; D011453:Prostaglandins; D011458:Prostaglandins E; C011512:alpha-naphthoflavone; D015232:Dinoprostone; D013755:Tetradecanoylphorbol Acetate