[Pharmacokinetics of the cephalosporin antibiotic cefotiam following its intravenous administration to patients after cholecystectomy].
The pharmacokinetic behaviour of cephalosporin antibiotic, second generation after intravenous administration to patients during the early post-operative period was characterized as well as after cholecystectomy. The data suggest a two-compartment distribution with elimination from the central compartment, realized on account of the renal way of clearance. In one of the patients, with one-compartment distribution of the drug, the presence of the theoretical determining factors in "the collapse" of one two-compartment open model to one-compartment is shown, associated with clinical characteristics of that patient.
Terziivanov
D
D
Gerova
Z
Z
Vlakhov
V
V
D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D015310:Cefotiam; D002763:Cholecystectomy; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D013997:Time Factors
D015310:Cefotiam; D002439:Cefotaxime
Farmakokinetika na tsefalosporinoviia antibiotik tsefotiam sled intravenozno vŭzvezhdane na bolni sled kholetsistektomiia.