title: A transcriptional enhancer with specificity for erythroid cells is located in the long terminal repeat of the Friend murine leukemia virus.
abstract: We investigated the ability of the U3 region of the long terminal repeats (LTR) of the Friend murine leukemia virus (Fr-MuLV) and Moloney murine leukemia virus (Mo-MuLV) to promote transcription in a variety of human cell lines. Our analysis reveals the presence of a transcriptional enhancer with specificity for erythroid cells in the U3 region of the Fr-MuLV. This constitutes the first example of an enhancer with such a property. Analysis of the Mo-MuLV enhancer suggests that it is active at least in erythroid and lymphoid cells and has thus a less restricted specificity than the Fr-MuLV enhancer. The different tissue specificities of the two enhancers correlate with the different tissue selectivities and pathogenic properties of the two viruses.
authors.forename: Z
authors.initials: Z
authors.lastname: Bösze
authors.forename: H J
authors.initials: HJ
authors.lastname: Thiesen
authors.forename: P
authors.initials: P
authors.lastname: Charnay
mesh_terms: D000123:Acetyltransferases / Q000235:genetics; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D015500:Chloramphenicol O-Acetyltransferase; D004742:Enhancer Elements, Genetic; D005622:Friend murine leukemia virus / Q000235:genetics*; D005796:Genes; D005809:Genes, Regulator; D005814:Genes, Viral; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D007951:Leukemia, Myeloid; D051379:Mice; D008979:Moloney murine leukemia virus / Q000235:genetics*; D010957:Plasmids; D012333:RNA, Messenger / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D014158:Transcription, Genetic; D014162:Transfection
chemical_list: D012333:RNA, Messenger; D000123:Acetyltransferases; D015500:Chloramphenicol O-Acetyltransferase