Adhesive bacterial colonization of exposed traumatized tendon.
Recent studies of compromised or damaged tissues, as well as biomaterials, have shown that they provide a particularly fertile substratum for bacterial colonization. Colonization in these environments is mediated by a process of microbial adhesion to surfaces of the substrata. In this report, we present electron microscopic studies of a portion of damaged and infected tendon. These studies demonstrate colonies of bacteria surrounded by a ruthenium red-staining exopolysaccharide biofilm and adhesion to the surface of the tendon by means of an exopolysaccharide polymer. We suggest that this adhesive form of bacterial colonization may partially explain the resistance of exposed tendon to effective debridement by simple mechanical measures and to coverage with granulation tissue, partial-thickness skin grafts, and vascularized tissue grafts.
Webb
L X
LX
Department of Surgery, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Hobgood
C D
CD
Meredith
J W
JW
Gristina
A G
AG
D000328:Adult; D001419:Bacteria / Q000302:isolation & purification / Q000648:ultrastructure; D001422:Bacterial Adhesion; D006230:Hand Injuries / Q000382:microbiology / Q000601:surgery; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D013708:Tendon Injuries / Q000382:microbiology* / Q000601:surgery; D014946:Wound Infection / Q000382:microbiology*