title: Pharmacokinetics of ofloxacin and theophylline alone and in combination.
abstract: The pharmacokinetic interactions of ofloxacin (2 X 200 mg) and theophylline (3 X 200 mg) were investigated in 12 healthy volunteers over a period of two weeks. In the first week, theophylline was given over five days to reach a steady state. In the second week, the combination of theophylline and ofloxacin was applied. Cmax, tmax, AUC0-8, the serum elimination constant and serum half-life of theophylline were not changed when theophylline was given alone or in combination with ofloxacin. The kinetic parameters of ofloxacin were in accordance with data from the literature.
authors.forename: J B
authors.initials: JB
authors.lastname: Fourtillan
authors.forename: J
authors.initials: J
authors.lastname: Granier
authors.forename: B
authors.initials: B
authors.lastname: Saint-Salvi
authors.forename: J
authors.initials: J
authors.lastname: Salmon
authors.forename: A
authors.initials: A
authors.lastname: Surjus
authors.forename: D
authors.initials: D
authors.lastname: Tremblay
authors.forename: M
authors.initials: M
authors.lastname: Vincent Du Laurier
authors.forename: S
authors.initials: S
authors.lastname: Beck
mesh_terms: D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood*; D004347:Drug Interactions; D006801:Humans; D007700:Kinetics; D008297:Male; D015242:Ofloxacin; D010078:Oxazines / Q000008:administration & dosage / Q000097:blood*; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood*
chemical_list: D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin; D013806:Theophylline