title: Lack of mitogenic effects of growth hormone on human leukemic lymphoblasts.
abstract: To determine whether human growth hormone (HGH) can cause proliferation of human leukemic lymphoblasts, we studied colony formation in semi-solid medium of MOLT 4, a cell line derived from an adolescent with acute lymphoblastic leukemia (ALL). Although exposure to single doses of HGH in supraphysiologic concentrations resulted in almost two-fold increases in number of colonies compared with control samples, physiologic concentrations had no effect. Similarly, physiologic concentrations of HGH had no effect on thymidine incorporation in short-term cultures of fresh lymphoblasts from children with ALL. In addition, total white blood cell and differential counts in 14 children with isolated growth hormone deficiency were reviewed pre- and post-treatment with HGH. In no case was there evidence of in vivo lymphocytosis or blastogenesis.
authors.forename: J
authors.initials: J
authors.lastname: Blatt
authors.forename: S
authors.initials: S
authors.lastname: Wenger
authors.forename: S
authors.initials: S
authors.lastname: Stitely
authors.forename: P A
authors.initials: PA
authors.lastname: Lee
mesh_terms: D002460:Cell Line; D002478:Cells, Cultured; D013006:Growth Hormone / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007945:Leukemia, Lymphoid / Q000473:pathology*; D008214:Lymphocytes / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects; D014410:Tumor Stem Cell Assay
chemical_list: D013006:Growth Hormone