[Evaluation of cognitive functions in patients with chronic renal insufficiency].
Fifteen undialyzed and thirteen dialyzed patients affected by chronic renal failure were studied by means of an extensive neuropsychological battery with the aim of assessing the incidence of a deterioration of cognitive functions. Mean performances scores obtained by the two groups of patients were compared with analogous scores obtained by a group of control subjects similar as for literacy and age. The comparisons among the three groups did not reveal any difference as for performance scores obtained to various tasks nor for the global assessment derived for the entire battery. Furthermore our data do not point out any significative correlation between global performances on neuropsychological battery and blood levels of creatinine and urea nitrogen or duration of dialytic treatment of renal subjects. In conclusion, the results of our study do not show evidence of cognitive impairment in subjects affected by chronic renal failure and do not confirm the hypothesis of a detrimental effect of prolonged periods of dialytic treatment on cognitive functions.
Caltagirone
C
C
Clinica Neurologica, II Università, Roma.
Carlesimo
A
A
Meloni
C
C
Morosetti
M
M
Taccone-Gallucci
M
M
Vicari
S
S
Casciani
C U
CU
D001806:Blood Urea Nitrogen; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology; D003404:Creatinine / Q000097:blood; D004493:Education; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D008875:Middle Aged; D009483:Neuropsychological Tests; D006435:Renal Dialysis / Q000009:adverse effects
D003404:Creatinine
Valutazione delle funzioni cognitive in soggetti con insufficienza renale cronica.