title: Neonatal necrotizing enterocolitis: a cause of gastric metaplasia in the mid-ileum.
abstract: Following neonatal necrotizing enterocolitis in a premature Aboriginal baby, a stricture developed in the distal small intestine. At laparotomy a 1.0 cm stricture was found in a 25 cm thick-walled, oedematous segment of the mid-ileum. Biopsy demonstrated antropyloric-type ectopic mucosa and, therefore, the oedematous segment was removed. The resected specimen contained several distinct areas of flat antropyloric gastric mucosa as well as ileal mucosa. Although no acid-producing cells could be demonstrated, mucosal ulceration was prominent in several areas. Scanning electron microscopy demonstrated gastric pits. Immunoperoxidase technique for gastrin failed to demonstrate gastrin-containing cells. It is believed that this mucosa represents a metaplasia that has been induced in response to mucosal damage, which in turn was initiated by necrotizing enterocolitis. It is believed this would represent the first reported case.
authors.forename: W D
authors.initials: WD
authors.lastname: Ford
authors.forename: G E
authors.initials: GE
authors.lastname: Phillips
authors.forename: G P
authors.initials: GP
authors.lastname: Davidson
authors.forename: B S
authors.initials: BS
authors.lastname: Douglas
mesh_terms: D002828:Choristoma / Q000209:etiology* / Q000473:pathology; D004761:Enterocolitis, Pseudomembranous / Q000150:complications / Q000473:pathology*; D005753:Gastric Mucosa / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007078:Ileal Neoplasms / Q000209:etiology* / Q000473:pathology; D007082:Ileum / Q000473:pathology; D007231:Infant, Newborn; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008679:Metaplasia; D008855:Microscopy, Electron, Scanning