[Postradiation impairment of tumor blood supply using polyradiomodification for increasing the effectiveness of radiotherapy].
A therapeutic effect of the postradiation use of methods disturbing the blood supply of malignant neoplasms: short-term hyperglycemia (STH), mexamine (M) and a tourniquet (T)--was assessed in experiments on mice with solid Ehrlich carcinoma. It was shown that an independent use of STH, M and T without radiation exposure did not possess a significant antitumor effect whereas their use shortly after irradiation enhanced the effect of the latter on tumors without increasing skin radiation injury in the zone of tumor growth. The utmost antitumor effect was achieved in combination of irradiation with immediate STH followed either by M or T: in these cases a tumor radiation effect was enhanced in different series of experiments 1.5-2-or over 3-fold. A conclusion has been made as to the importance of the blood supply inhibition in malignant tumors in the postradiation period.
Kozin
S V
SV
Voloshina
E A
EA
D008735:5-Methoxytryptamine / Q000627:therapeutic use; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002286:Carcinoma, Ehrlich Tumor / Q000098:blood supply* / Q000532:radiotherapy; D003131:Combined Modality Therapy; D003250:Constriction; D008297:Male; D051379:Mice; D014111:Tourniquets
D001786:Blood Glucose; D008735:5-Methoxytryptamine
Postradiatsionnoe narushenie krovosnabzheniia opukholeĭ pri poliradiomodifikatsii dlia povysheniia éffektivnosti luchevoĭ terapii.