title: Microsomal N-oxidation of long chain N,N-dimethylalkylamines: quantitative structure-activity relationships.
abstract: N,N-Dimethylalkylamines CmH2m+1N(CH3)2 (m = 4 to 18) undergo in vitro N-oxidation to the corresponding amine oxides by mouse liver microsomes. The relative oxidisability of these compounds is parabolically dependent on structural and physico-chemical characteristics (with a maximum at m 12) and is controlled by at least three factors: lipophilicity, stereochemistry and the nucleophilicity of the compounds under evaluation. The results from the QSAR study support this multifactorial view.
authors.affiliation: Chelsea Department of Pharmacy, King's College London, University of London, UK.
authors.forename: F
authors.initials: F
authors.lastname: Devinsky
authors.forename: J W
authors.initials: JW
authors.lastname: Gorrod
mesh_terms: D000818:Animals; D004123:Dimethylamines / Q000032:analysis / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000032:analysis / Q000378:metabolism*; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship
chemical_list: D004123:Dimethylamines