Acute promyelocytic transformation of chronic myeloid leukaemia with an isochromosome 17q.
Transformation to an acute promyelocytic leukaemia occurred in a patient approximately 2 years after having been diagnosed as suffering from chronic myeloid leukaemia (CML). At this time, in addition to the Ph1 chromosomal aberration, an isochromosome 17q [i(17q)] was noted. The t(15:17) was absent. The implications of this are discussed.
van der Merwe
T
T
Bernstein
R
R
Derman
D
D
Stanley
A
A
Dukes
I
I
Murray
J
J
Weaving
A
A
D001752:Blast Crisis; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome