title: [Short, middle and long-term outcome of major peri-intraventricular hemorrhages].
abstract: Within 4 years 10 months (1981-1985), the Port-Royal Neonatal Intensive Care Unit admitted 2,400 neonates, one third with a birthweight below 1,501 g; 4,631 cranial ultrasound studies were performed in 1,488 of those neonates, mostly less than 1,501 g, detecting 392 consecutive peri-intraventricular hemorrhages (PIVH), of which 130 were major forms (from unilateral grade III to bilateral grade IV PIVH). Overall survival rates were 91% in grade I, 85% in grade II, 42% in grade III, 26% in grade IV; survival rate was significantly lower in bilateral than in unilateral grade II and III PIVH. In major PIVH, deaths occurred early (58% in the first week after birth). Post-hemorrhagic dilatation was constant but mostly regressive; true active hydrocephalus appeared in 1 unilateral grade III PIVH and 8 bilateral grade III PIVH, with ventriculo-peritoneal shunt in the second month of life in 5 infants (2 died), and 4 deaths (surgery not feasible). The neurological and developmental outcome of 42 of 46 survivors (4 losts to follow-up) was evaluated beyond one year of age in 12 unilateral grade III PIVH (10 normal children, 1 minor sequela, 1 moderate sequela), 16 bilateral grade III PIVH (7 normal children, 3 minor sequelae, 1 moderate sequela, 5 major sequelae), 13 unilateral grade IV PIVH (8 normal children, 1 minor sequela, 3 moderate sequelae, 1 major sequela), 1 bilateral grade IV PIVH (major sequela). A persistent major dilatation after 6-9 months of age bore an ominous prognosis.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Centre de Recherches de Biologie du Développement de l'Association Claude-Bernard CHU Cochin Port-Royal, Paris.
authors.forename: M
authors.initials: M
authors.lastname: Monset-Couchard
authors.forename: O
authors.initials: O
authors.lastname: de Bethmann
authors.forename: M F
authors.initials: MF
authors.lastname: Radvanyi
authors.forename: G
authors.initials: G
authors.lastname: Moriette
authors.forename: C
authors.initials: C
authors.lastname: Papin
authors.forename: J P
authors.initials: JP
authors.lastname: Relier
mesh_terms: D002543:Cerebral Hemorrhage / Q000150:complications* / Q000401:mortality; D002552:Cerebral Ventricles; D004108:Dilatation, Pathologic; D004569:Electroencephalography; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D009422:Nervous System Diseases / Q000209:etiology; D011379:Prognosis; D013997:Time Factors
vernacular_title: Devenir des hémorragies péri-intraventriculaires majeures à court, moyen et long terme.