title: Reciprocal translocation (11;19)(q23;p13) in congenital acute lymphoblastic leukemia.
abstract: The cytogenetic, clinical, and immunologic findings ina 4-month-old girl with acute lymphoblastic leukemia (ALL) are reported. The malignant lymphoblasts were characterized cytogenetically by the reciprocal translocation t(11;19)(q23;p13); immunologically by an immature pre-B-ALL phenotype. In spite of the high-risk nature of the leukemia, the patient attained complete remission relatively quickly and is still free of disease 3 years after diagnosis. Because the only two previously reported ALL patients with t(11;19) also seem to have responded well to therapy, this cytogenetic abnormality might turn out to be an indicator of favorable prognosis in ALL.
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: U
authors.initials: U
authors.lastname: Kristoffersson
authors.forename: N
authors.initials: N
authors.lastname: Mandahl
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
authors.forename: A N
authors.initials: AN
authors.lastname: Bekassy
authors.forename: S
authors.initials: S
authors.lastname: Garwicz
authors.forename: J
authors.initials: J
authors.lastname: Heldrup
authors.forename: T
authors.initials: T
authors.lastname: Wiebe
mesh_terms: D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000151:congenital* / Q000235:genetics; D014178:Translocation, Genetic