Adenoviruses of subgenera B, C, D, and E modulate cell-surface expression of major histocompatibility complex class I antigens.
The immune defense against viral infections involves cytotoxic T lymphocytes that recognize viral products in the context of class I major histocompatibility complex (MHC) antigens. To evade such immune surveillance viruses may have evolved various strategies to manipulate the expression of class I antigens. Adenovirus 2 manufactures an early glycoprotein, E19, that binds to nascent class I antigens in the endoplasmic reticulum and impedes their transport to the cell surface. We now show that adenoviruses typical of all viral subgenera except the highly oncogenic subgenus A dramatically reduce the cell-surface expression of class I antigens. It has been shown that subgenus A viruses abolish class I antigen expression in transformed cells by reducing mRNA levels. Thus, all adenoviruses can modulate the cell-surface expression of class I antigens.
Pääbo
S
S
Nilsson
T
T
Peterson
P A
PA
D000260:Adenoviruses, Human / Q000145:classification / Q000276:immunology*; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D001692:Biological Transport; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D006031:Glycosylation; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D013045:Species Specificity; D014764:Viral Proteins / Q000276:immunology
D000954:Antigens, Surface; D000956:Antigens, Viral; D006680:HLA Antigens; D008565:Membrane Proteins; D014764:Viral Proteins