Protein A and acid alpha-1-glycoprotein as factors discriminating immunoglobulins G in children suffering from leukemias.
The studies on IgG-3 subclass in the course of acute lymphoblastic leukemia (ALL) in children were performed. The presence of this IgG subclass was not shown, using chromatography on AGP-Sepharose for its isolation and Protein A-Sepharose for its identification. The possibilities of excretion of this IgG subclass with urine and proteolytic digestion in neutral pH by serum enzymes were excluded. Acid alpha-1-glycoprotein (AGP) isolated from serum of children with ALL interacts with IgG-3 of normal serum.
Wróblewski
Z
Z
Mejbaum-Katzenellenbogen
W
W
Halikowski
B
B
D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000145:classification / Q000652:urine; D007223:Infant; D007945:Leukemia, Lymphoid / Q000097:blood*; D008297:Male; D009961:Orosomucoid / Q000378:metabolism*; D011485:Protein Binding; D013205:Staphylococcal Protein A / Q000378:metabolism*
D007074:Immunoglobulin G; D009961:Orosomucoid; D013205:Staphylococcal Protein A