Our experience with combined hemodialysis-hemoperfusion treatment in chronic uremia.
Hemodialysis can remove only substances that are highly diffusable, non protein bound and with small and middle-molecular weights. The combination of Hemodialysis-Hemoperfusion (HD-HF) takes advantage of both techniques. Uremic patient could reduce the number of weekly dialysis sessions. Fourteen uremic patients were submitted twice a week to a combined HD-HP treatment for 16 months. Polymethacrylate coated charcoal was inserted in the dialysis circuit before the dialyzer. The treatment resulted in improvement of: MNCV (30.5 + -6 to 38.7 + -5.6 m/sec.) subjective symptoms (disappearance of pruritus and insomnia) and hematological status (red blood cells 3.1 x 106 to 4.02 x 106; and hematocrits 28.3 to 36.1). Good control of serum biochemistries. Creatinine and urea clearances of 228 and 236 ml/min respectively. Significant removal of middle-molecules uremic toxins determinated by gel-filtration on Sephadex G15. In conclusion, we state that combined HD-HP improves the detoxication possibilities in chronic uremia.
Splendiani
G
G
S. Salvatore University Hospital, L'Aquila Italy.
Albano
V
V
Tancredi
M
M
Daniele
M
M
Pignatelli
F
F
D002606:Charcoal; D003404:Creatinine / Q000097:blood / Q000302:isolation & purification; D006464:Hemoperfusion; D006801:Humans; D006435:Renal Dialysis; D014118:Toxins, Biological / Q000097:blood / Q000302:isolation & purification; D014508:Urea / Q000097:blood / Q000302:isolation & purification; D014511:Uremia / Q000097:blood / Q000628:therapy*
D014118:Toxins, Biological; C026865:uremia middle molecule toxins; D002606:Charcoal; D014508:Urea; D003404:Creatinine