[Experimental evaluation of dura mater permeability on a model of peridural analgesia with morphine and dikain].
The permeability of spinal dura mater (DM) in 14 people after sudden death was studied on the model of peridural analgesia with morphine and dikain. The DM permeability was found to linearly increase in caudal direction and within the limits of 10 segments of thoracolumbar section of the peridural space (from T2-3 to L1-2) it is increased by 170% for morphine and 200% for dikain. The diffusion of 14-18% of the epidurally injected dosage of morphine and 18-27% of dikain through the dura mater takes place depending on the segmentary level. This correlation should be taken into account for the achievement of the most pronounced antinociceptive effect and prevention of complications.
Vitenbek
I A
IA
D000328:Adult; D000767:Anesthesia, Epidural; D004388:Dura Mater / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D008954:Models, Biological; D009020:Morphine / Q000493:pharmacokinetics*; D010539:Permeability; D013748:Tetracaine / Q000493:pharmacokinetics*
D013748:Tetracaine; D009020:Morphine
Eksperimental'naia otsenka pronitsaemosti tverdoĭ mozgovoĭ obolochki na modeli peridural'noĭ analgezii morfinom i dikainom.