Rapidly reversible resistance to immune lysis of L5178Y lymphoma cells in a tumor-dormant state in DBA/2 mice.
L5178Y cells in a tumor-dormant state in DBA/2 mice escape lysis by cytolytic T-lymphocytes and activated macrophages. In the present report these tumor cells were found to be less susceptible to lysis by anti-H-2, anti-Thy 1.2, and anti-AKR antibodies plus complement than was the same tumor cell population removed from tumor-dormant mice and allowed to proliferate in a nonimmune environment in vivo or in vitro. This rapidly reversible resistance to immune lysis may be due to arrest of the tumor cells in the cell cycle during the tumor-dormant state.
Okayasu
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Wheelock
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D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D003165:Complement System Proteins / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D005260:Female; D007518:Isoantibodies / Q000276:immunology; D008223:Lymphoma / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008811:Mice, Inbred DBA; D009439:Neuraminidase / Q000494:pharmacology; D013997:Time Factors
D007518:Isoantibodies; C035678:anti-Thy antibody; D003165:Complement System Proteins; D009439:Neuraminidase