title: [CA-50 in serum of patients with carcinoma. Clinical experiences with a new tumor marker].
abstract: Quantitative radioimmunological demonstration of carbohydrate antigen CA-50 in serum achieved a sensitivity of 62.3% for colorectal carcinoma (n = 53), of 64.7% for gastric carcinoma (n = 34), of 33.9% for lung carcinoma (n = 56), and 19.8% for lymphoproliferative diseases (n = 91). The positive results for the latter probably correspond to the immunohistological demonstration of the antigen in dendritic reticulum cells. Occasionally an increased CA-50 level in inflammatory disease presents difficulties in differential diagnosis, but it returns to normal when the inflammatory process has subsided. Methodological scatter of the CA-50 system is satisfactory, with a coefficient of variation of +/- 11%, but unsatisfactory at low values (less than or equal to 10 U/ml) and high ones (greater than or equal to 50 U/ml) with a coefficient of variation of +/- 19%. Further development with the IMRA technique may significantly reduce methodological scatter (coefficient of variation +/- 5%).
authors.forename: H D
authors.initials: HD
authors.lastname: Bruhn
authors.forename: H
authors.initials: H
authors.lastname: Broers
authors.forename: H
authors.initials: H
authors.lastname: Euler
authors.forename: A
authors.initials: A
authors.lastname: Everding
authors.forename: A C
authors.initials: AC
authors.lastname: Feller
authors.forename: J
authors.initials: J
authors.lastname: Hedderich
authors.forename: L
authors.initials: L
authors.lastname: Jostarndt
authors.forename: B
authors.initials: B
authors.lastname: Jooss
authors.forename: K H
authors.initials: KH
authors.lastname: Zurborn
authors.forename: H
authors.initials: H
authors.lastname: Löffler
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis* / Q000276:immunology; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000276:immunology; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000276:immunology; D011863:Radioimmunoassay; D012004:Rectal Neoplasms / Q000175:diagnosis* / Q000276:immunology; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000276:immunology
chemical_list: D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen
vernacular_title: CA-50 im Serum von Karzinom-Patienten. Klinische Erfahrungen mit einem neuen Tumormarker.