title: Acute myelomonocytic leukemia (M4) with eosinophilia: problems concerning chromosome 16 abnormality.
abstract: A case of acute myelomonocytic leukemia is reported which was hematologically classified as M4 (FAB), because the patient had a high count of immature eosinophils with typical histochemical features in the bone marrow. An abnormal chromosome #16 was found besides a trisomy 22 or a monosomy 18 in part of the cultured bone marrow cells and unstimulated blood cells but not in directly prepared bone marrow. The structural aberration of chromosomes #16, which was demonstrated best by CBG-banding, was more likely due to a partial deletion of the long arm than to an inversion. The difficulties involved in correct cytogenetic diagnosis of such cases are discussed.
authors.forename: H
authors.initials: H
authors.lastname: Harth
authors.forename: H
authors.initials: H
authors.lastname: Pees
authors.forename: H
authors.initials: H
authors.lastname: Zankl
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002885:Chromosomes, Human, Pair 16; D004802:Eosinophilia / Q000150:complications / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics*; D008214:Lymphocytes / Q000166:cytology; D008875:Middle Aged