No difference between urinary mutagenicity in smokers of low-tar and medium-tar cigarettes: a double-blind cross-over study.
Urinary mutagenicity, blood carboxyhemoglobin and serum thiocyanate levels were measured in young, healthy volunteers smoking a fixed number of either low-tar (5 mg/cig.) or medium-tar (15 mg/cig.) cigarettes. The experiment was performed in a double-blind cross-over fashion. The volunteers were under daily control, and their diet and environment were standardized. The urinary mutagenic activity responded dose-dependently to the number of cigarettes smoked (0, 5, 10 or 20 per day), but there was no difference between the smokers of low-tar and medium-tar cigarettes. Neither were any significant differences found in blood carboxyhemoglobin nor serum thiocyanate. These results suggest that there is no substantial difference between the low-tar and medium-tar cigarette as to the inhalation of hazardous compounds in the real smoking situation.
Tuomisto
J
J
Kolonen
S
S
Sorsa
M
M
Einistö
P
P
D000328:Adult; D002263:Carboxyhemoglobin / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009153:Mutagens / Q000378:metabolism*; D010947:Plants, Toxic; D012907:Smoking; D013638:Tars / Q000032:analysis*; D013861:Thiocyanates / Q000097:blood; D014026:Nicotiana / Q000032:analysis*
D009153:Mutagens; D013638:Tars; D013861:Thiocyanates; D002263:Carboxyhemoglobin; C031760:thiocyanate