title: Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13----q23 region of chromosome 5.
abstract: We have used hamster cDNA probes for 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase (HMGCR) to determine the chromosomal location of the human gene for HMG CoA reductase. Southern blot analysis of genomic DNA from 16 independent mouse-human somatic cell hybrids showed that the human gene for HMG CoA reductase resides on chromosome 5. Analysis of Chinese hamster-human somatic cell hybrids selectively retaining human 5 or a portion of it showed that the gene locus for HMG CoA reductase can be assigned to the q13----q23 region of chromosome 5.
authors.forename: T
authors.initials: T
authors.lastname: Mohandas
authors.forename: C
authors.initials: C
authors.lastname: Heinzmann
authors.forename: R S
authors.initials: RS
authors.lastname: Sparkes
authors.forename: J
authors.initials: J
authors.lastname: Wasmuth
authors.forename: P
authors.initials: P
authors.lastname: Edwards
authors.forename: A J
authors.initials: AJ
authors.lastname: Lusis
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002905:Chromosomes, Human, 4-5; D004247:DNA / Q000235:genetics; D004587:Electrophoresis, Agar Gel; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics*; D051379:Mice
chemical_list: D004247:DNA; D006903:Hydroxymethylglutaryl CoA Reductases