title: Estradiol and progesterone binding in uterine leiomyomata and pregnant myometrium.
abstract: In order to verify the endogenous steroid influences on the myometrium, we compared the receptor status in 18 specimens of uterine leiomyomata and 31 specimens of pregnant myometrium. 17-beta-Estradiol and Progesterone receptors were assayed in the cytosol and nuclear extracts. In the uterine leiomyomata we observed the following mean values: PgR/c 279 fmol/mg, PgR/n 89 fmol/mg, ER/c 52.5 fmol/mg, ER/n 12.3 fmol/mg. In the pregnant myometrium we observed the following mean values: PgR/c 5.86 fmol/mg, PgR/n 166 fmol/mg, ER/c 0.76 fmol/mg, ER/n 1.65. It was concluded that direct correlation between estrogen power and progesterone receptor replenishment in the nucleus exists.
authors.affiliation: Institute of Obstetrics and Gynaecology, University of Padua, Italy.
authors.forename: G B
authors.initials: GB
authors.lastname: Nardelli
authors.forename: M
authors.initials: M
authors.lastname: Mega
authors.forename: M
authors.initials: M
authors.lastname: Bertasi
authors.forename: F
authors.initials: F
authors.lastname: Siliotti
mesh_terms: D002467:Cell Nucleus / Q000648:ultrastructure; D002585:Cesarean Section; D003593:Cytoplasm / Q000648:ultrastructure; D003600:Cytosol / Q000648:ultrastructure; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology*; D011374:Progesterone / Q000378:metabolism*; D011959:Receptors, Estradiol / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000473:pathology*; D014599:Uterus / Q000473:pathology
chemical_list: D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol