[Behavior of glucosephosphate isomerase in children with malignant diseases].
The normal range of glucose-phosphate-isomerase (GPI) in the plasma of children during the first month of life is up to 80 U/l; until the end of the second year of life between 11 and 50 U/l; thereafter the upper limit is 46 U/l. In osteogenic sarcoma or medulloblastoma there is a good correlation between activity of GPI in plasma and clinical tumor stage. In a lot of other tumors sensitivity of this enzyme is either very low as in Ewing-sarcoma or myeloic leukemia or there is no consistent relation to the extent of the tumor. High activities of GPI are equally obtained in children suffering from cystic fibrosis, diabetes mellitus or muscular dystrophy. GPI is not valid as a tumor marker even being raised in sarcoma and medulloblastoma as mentioned. So it is not necessary to check GPI activity as a part of routine enzyme chemistry.
Hohenberger
P
P
Graf
N
N
Sitzmann
F C
FC
Rupp
S
S
D000293:Adolescent; D000367:Age Factors; D001859:Bone Neoplasms / Q000201:enzymology; D002528:Cerebellar Neoplasms / Q000201:enzymology; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D005956:Glucose-6-Phosphate Isomerase / Q000097:blood*; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000201:enzymology; D008527:Medulloblastoma / Q000201:enzymology; D009369:Neoplasms / Q000175:diagnosis / Q000201:enzymology*; D012516:Osteosarcoma / Q000201:enzymology; D012016:Reference Values
D005956:Glucose-6-Phosphate Isomerase
Verhalten der Glucose-Phosphat-Isomerase bei Kindern mit malignen Erkrankungen.