A biochemical characterization of feline MHC products: unusually high expression of class II antigens on peripheral blood lymphocytes.
The polymorphism of feline MHC antigens was examined using biochemical methods. The following observations were made: (1) feline class I and II antigens are polymorphic. Their biochemical features were established using rabbit and mouse reagents directed against human MHC products; they resemble those observed for other mammalian species; (2) the expression of class II antigens in unstimulated cat peripheral blood lymphocytes (PBLs) appears to be unusually high. Cat PBLs express far more class II than class I antigens, whereas in human Epstein-Barr virus-transformed lines, which are known to express relatively large amounts of class II antigens, the situation is reversed.
Neefjes
J J
JJ
Hensen
E J
EJ
de Kroon
T I
TI
Ploegh
H L
HL
D000818:Animals; D000911:Antibodies, Monoclonal; D002415:Cats / Q000276:immunology*; D003902:Detergents; D006649:Histocompatibility Antigens / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007526:Isoelectric Point; D008214:Lymphocytes / Q000276:immunology*; D008285:Major Histocompatibility Complex; D008565:Membrane Proteins / Q000032:analysis; D008970:Molecular Weight
D000911:Antibodies, Monoclonal; D003902:Detergents; D006649:Histocompatibility Antigens; D000949:Histocompatibility Antigens Class II; D008565:Membrane Proteins