[Depolarizing action of dopamine on the endings of the primary afferent fibers of an isolated segment of the spinal cord in rat pups].
The effect of dopamine on the dorsal root potential was studied in the isolated superfused spinal cord of 12-18-day old rats. It was established that application of dopamine in concentration of 1.10(-9)-1.10(-3) mol/l caused the reversible dose-dependent depolarization in the dorsal root. The depolarization was retained in the calcium-free solution with magnesium or manganese ions. Its maximal amplitude reached 1.5 mV. Haloperidol, a dopamine antagonist, decreased depolarization evoked by dopamine. The possibility of dopaminergic brainstem-spinal pathways participation in the control of the sensory information transmission at the spinal cord entrance is discussed.
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D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005727:Ganglia, Spinal / Q000187:drug effects / Q000502:physiology; D006220:Haloperidol / Q000494:pharmacology; D066298:In Vitro Techniques; D009411:Nerve Endings / Q000187:drug effects* / Q000502:physiology; D010477:Perfusion / Q000379:methods; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D005680:gamma-Aminobutyric Acid; D006220:Haloperidol; D004298:Dopamine
Depoliarizuiushchee deĭstvie dofamina na terminali pervichnykh afferentnykh volokon izolirovannogo segmenta spinnogo mozga krysiat.