Translocation (9;11)(p21;q23) in a child with acute monoblastic leukemia following 2 1/2 years after successful chemotherapy for neuroblastoma.
This is a case report of a 4 1/2-year-old boy who developed acute monoblastic leukemia 2 1/2 years after he had been treated successfully with combined chemotherapy for neuroblastoma. All analyzable bone marrow-derived metaphases had the karyotype 47,XY, + 8,t(9;11)(p21;q23). The rare occurrence of specific chromosomal translocations in leukemias following prior chemotherapy and/or radiotherapy and their possible clinical implications in such cases are discussed.
Weh
H J
HJ
Kabisch
H
H
Landbeck
G
G
Hossfeld
D K
DK
D000208:Acute Disease; D000310:Adrenal Gland Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001853:Bone Marrow / Q000648:ultrastructure; D002675:Child, Preschool; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000139:chemically induced* / Q000235:genetics; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy* / Q000473:pathology; D014178:Translocation, Genetic