Streptomyces albus G produces an antibiotic complex identical to paulomycins A and B.
An antibiotic complex active against multiply resistant strains of staphylococci and other Gram-positive bacteria was isolated from cultures of Streptomyces albus G. Silica gel and Sephadex LH-20 column chromatography gave two congeners with Mr values of 786 and 772, which differed by one -CH2-group. The two homologues contained an isothiocyanate group, and proved to be identical with paulomycins A and B produced by Streptomyces paulus; the FAB mass spectra, in addition, proved the same two congeners to be present in proceomycin obtained from Streptomyces alboniger.
Majer
J
J
Northwestern University Medical School, Chicago, Illinois 60611.
Chater
K F
KF
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D004187:Disaccharides / Q000096:biosynthesis; D004352:Drug Resistance, Microbial; D013058:Mass Spectrometry; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D004187:Disaccharides; C034570:paulomycin B; C034569:paulomycin A