Acute effect of ethanol administration on platelet function.
The acute effect of single dose of ethanol (1.5 g kg) and aspirin (10 mg/kg) alone and in combination, on platelet aggregation time and platelet adhesiveness were studied in rabbits. There was a significant and comparable increase in aggregation time both by aspirin and ethanol. Similarly platelet adhesiveness was decreased by both the agents.
Sudhir
S
S
Department of Pharmacology and Blood Bank, Medical College, Haryana.
Gupta
L C
LC
Singh
J
J
Budhiraja
R D
RD
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D008297:Male; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits
D000431:Ethanol; D001241:Aspirin