[Effect of T-activin on enzymes in the metabolism of xenobiotics].
Effect of T-activin on some xenobiotic metabolizing enzymes and several immunity parametres in secondary immune deficiency (subacute and chronic benzene intoxication) were investigated. T-activin was shown to regulate the xenobiotic metabolizing enzyme system. The compound decreased the enzymatic activity in subacute benzene intoxication, approaching their values up to the control level. In chronic benzene intoxications, which were accompanied by decrease in xenobiotic metabolizing enzymes activity, except of glutathione-S-transferase, T-activin stimulated these enzymes. At the same time, T-activin increased some immunological parameters in these models. Thymus-tropic peptides appear to be the bioregulators of some in vivo systems.
Arion
V Ia
VIa
Khromenkov
Iu I
IuI
Tagirova
A K
AK
Karaulov
A V
AV
Breusov
Iu N
IuN
D000276:Adjuvants, Immunologic; D000818:Animals; D001554:Benzene / Q000506:poisoning; D004789:Enzyme Activation; D007107:Immune System; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010455:Peptides / Q000494:pharmacology*; D013949:Thymus Extracts / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin; D006899:Mixed Function Oxygenases; D001554:Benzene
Vliianie T-aktivina na fermenty metabolizma ksenobiotikov.