title: Translocation of protein kinase C in rat hippocampal slices.
abstract: Tumor-promoting phorbol esters specifically activate protein kinase C and mimic the effects of neurotransmitters in certain systems. Treatment of hippocampal slices with phorbol dibutyrate caused translocation of protein kinase C activity from cytoplasm to membranes. Experiments with carbachol, norepinephrine, glutamate, KCl, and LiCl failed to demonstrate a similar translocation. Translocation more readily provides an index of protein kinase C involvement for phorbol esters than for other agents in hippocampus.
authors.forename: M
authors.initials: M
authors.lastname: Zatz
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002273:Carcinogens / Q000494:pharmacology; D003593:Cytoplasm / Q000187:drug effects* / Q000201:enzymology; D006624:Hippocampus / Q000187:drug effects* / Q000201:enzymology; D066298:In Vitro Techniques; D008297:Male; D015240:Phorbol 12,13-Dibutyrate; D010703:Phorbol Esters / Q000494:pharmacology*; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013570:Synaptic Membranes / Q000187:drug effects* / Q000201:enzymology
chemical_list: D002273:Carcinogens; D010703:Phorbol Esters; D015240:Phorbol 12,13-Dibutyrate; D011493:Protein Kinase C