Surface area sized of intravitreal iron wires: their effects on the electroretinograms of rats.
The electroretinogram (ERG) was recorded 20 times over a period of 360 days in 26 albino-rats with implanted intravitreal iron wires ranging in size between 0.15 and 1.2 mm2.


RESULTS
(i) The a- and b-wave amplitudes decreased rapidly within one day after iron wire implantation. During the following week the amplitudes recovered to some extent. In the course of the next few months the a- and b-wave amplitudes of the eyes implanted with the largest iron wires (1.2 mm2) decreased steadily to about 20% by the end of the observation time, whereas in the groups containing smaller iron wires the electroretinographic changes were limited. (ii) Implantation of equally-sized glass splinters reduced the a- and b-wave amplitudes to 65-75% in comparison to the intact fellow eye. Fast recovery of both potentials to 83-93% followed within two weeks. The mean values of the a-wave amplitudes reached nearly 100%, those of the b-wave 90-95% in the next month.
Schmidt
J G
JG
Universitäts-Augenklinik, Köln, FRG.
Max
M
M
D000818:Animals; D004596:Electroretinography; D005129:Eye Foreign Bodies / Q000473:pathology / Q000503:physiopathology*; D007501:Iron / Q000494:pharmacology*; D009887:Ophthalmoscopy; D010316:Particle Size; D051381:Rats; D011919:Rats, Inbred Strains; D014822:Vitreous Body
D007501:Iron