title: Double-blind study of imipramine versus phenelzine in Melancholias and Dysthymic Disorders.
abstract: In a 6-week double-blind trial, the efficacy of imipramine and high dose phenelzine were compared in the treatment of Major Depression with Melancholia, and Dysthymic Disorder (DSM-III). Both drugs were found to be equally efficacious in the treatment of 32 patients suffering from Major Depression. In 32 Dysthymic patients, phenelzine in high doses was found to be superior to imipramine. The clinical implications of these findings are discussed.
authors.affiliation: Department of Psychiatry, University Hospital, University of Barcelona.
authors.forename: J
authors.initials: J
authors.lastname: Vallejo
authors.forename: C
authors.initials: C
authors.lastname: Gasto
authors.forename: R
authors.initials: R
authors.lastname: Catalan
authors.forename: M
authors.initials: M
authors.lastname: Salamero
mesh_terms: D000293:Adolescent; D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010624:Phenelzine / Q000627:therapeutic use*; D011897:Random Allocation
chemical_list: D010624:Phenelzine; D007099:Imipramine