[Effect of preliminary administration of prostaglandin E2 and the prostaglandin synthesis inhibitor indomethacin on disturbances of myocardial contraction during stress].
The effect of preliminary administration of indometacin and prostaglandin E2 on right atrial myocardial distensibility and contractility disturbances was studied in male Wistar rats after 6-hour immobilization stress. Indometacin administration (5 mg/kg) increased stress-related atrial distensibility and contractility disturbances, while prostaglandin E2 administration (5 mg/kg) significantly limited these stress-induced responses.
Shimkovich
M V
MV
Pshennikova
M G
MG
D000818:Animals; D015232:Dinoprostone; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology* / Q000517:prevention & control
D011458:Prostaglandins E; D015232:Dinoprostone; D007213:Indomethacin
Vliianie predvaritel'nogo vvedeniia prostaglandina E2 i ingibitora sinteza prostaglandinov indometatsina na narushenie sokratitel'noĭ funktsii serdtsa pri stresse.