Twenty-four hour intragastric acidity during treatment with oral omeprazole.
In a series of 59 experiments on nine duodenal ulcer patients, 24-hour intragastric acidity was measured before, during and after treatment with daily oral omeprazole. Omeprazole, 10, 20, ro 30 mg/day for 1 week, caused a 37%, 90%, and 97% decrease respectively of 24-hour intragastric acidity. No further decrease of acidity was observed when the dose of omeprazole was doubled to 60 mg/day, or after a second week of treatment with 30 mg/day. One week after stopping treatment with omeprazole (14 doses), there was still a significant 26% decrease of 24-hour intragastric acidity, with full recovery 7 weeks later. Fasting plasma gastrin concentration was significantly elevated during treatment with all doses of omeprazole. The optimal dose of omeprazole is 30 mg/day for a maximal decrease of 24-hour intragastric acidity in duodenal ulcer patients.
Pounder
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RE
Sharma
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Walt
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RP
D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005215:Fasting; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005755:Gastrins / Q000097:blood; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009853:Omeprazole; D013997:Time Factors
D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D005755:Gastrins; D009853:Omeprazole