Influence of beta-aminopropionitril on media hypertrophy and baroreceptor reflex in normotensive and hypertensive rats.
Experiments were performed to investigate the antihypertensive action of beta-aminopropionitril (BAPN) in normotensive and hypertensive rats and to elucidate the role of media hypertrophy and arterial wall distensibility on baroreceptor reflex and blood pressure (BP) regulation. Normotensive Wistar-Kyoto rats (WKY), DOCA-salt hypertensive WKY, and stroke-prone spontaneously hypertensive rats (SHRSP) were treated with BAPN (100 mg/kg per day, intraperitoneally) for 10 weeks. The respective control groups (n = 10 per group) received 0.9% NaC1 instead of BAPN. In BAPN-treated groups the BP of DOCA-salt WKY (145 versus 170 mmHg) and SHRSP (170 versus 208 mmHg) was lower than that of controls at the end of the treatment period. In BAPN-treated rats, the medial cross-sectional area was reduced, postmortem distensibility of vascular wall was greater, and baroreceptor reflex, estimated from heart rate responses to BP changes, showed steeper regression curves. The BAPN-induced BP decrease in the hypertensive rats demonstrates that the level of sensitivity of the baroreceptor reflex is related to the mechanical properties of the arterial wall.
Fischer
M
M
Wessler
D
D
Henrichs
K J
KJ
Unger
T
T
D000629:Aminopropionitrile / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D011311:Pressoreceptors / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D012018:Reflex / Q000187:drug effects*
D000959:Antihypertensive Agents; D000629:Aminopropionitrile