Sex ratio and testis size in mice carrying Sxr and T(X;16)16H.
Mice heterozygous for the T(X;16)16H translocation and carrying Sxr on their normal (inactive) X chromosome (ie, T16H/X Sxr individuals) may develop as males, females, or hermaphrodites. The proportion of males varied from 22% to 65% depending on the source of the normal X chromosome. A model is proposed, according to which relatively small variations in the spreading of inactivation from the X chromosome into the attached Sxr fragment produce large changes in the proportion of males. Testis weight in T16H/X Sxr males was found to be significantly smaller than in X/X Sxr males, irrespective of the source of the normal X chromosome.
McLaren
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MRC Mammalian Development Unit, University College London, United Kingdom.
D000818:Animals; D012734:Disorders of Sex Development; D005260:Female; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics*; D012729:Sex Chromosome Aberrations; D012732:Sex Determination Analysis; D012744:Sex Ratio; D013737:Testis / Q000033:anatomy & histology*; D014178:Translocation, Genetic; D014960:X Chromosome