title: PROTEUS: a suite of programs for prediction of structural features of proteins using an Apple IIe.
abstract: We have implemented several algorithms, developed by various authors for predicting structural features of proteins from their primary structure, on an Apple IIe and collected them in a suite, named PROTEUS. This suite incorporates: (i) methods for predicting secondary structure; (ii) the algorithm for computing the hydropathy profile using one out of five available sets of parameters; (iii) the algorithms for calculating the hydrophobic moment plot; and (iv) for performing the amphipathic analysis using one out of four available sets of parameters. The suite has a utility program for storing on a disk the sequence to be analysed. As an example, we applied some of the methods included in PROTEUS to predict the structure of a mitochondrial leader peptide. The results suggest the occurrence of structural features possibly related to the import of proteins into mitochondria.
authors.affiliation: Dipartimento di Scienze Biochimiche, Universitá La Sapienza, Roma, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Pascarella
authors.forename: F
authors.initials: F
authors.lastname: Bossa
mesh_terms: D000465:Algorithms; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003201:Computers; D008838:Microcomputers; D011487:Protein Conformation; D011506:Proteins; D012984:Software; D012985:Software Design
chemical_list: D011506:Proteins