title: Evidence of digoxin metabolism by the kidney.
abstract: By performing single pass experiments in the dog, we could identify by thin layer chromatography a digoxin metabolite produced by the kidney. In vitro studies verify that this new species is produced by the brush border membrane of the renal tubular cell.
authors.affiliation: Department of Pediatrics, Hospital for Sick Children, Toronto, Ont., Canada.
authors.forename: G
authors.initials: G
authors.lastname: Koren
authors.forename: J
authors.initials: J
authors.lastname: Klein
authors.forename: M
authors.initials: M
authors.lastname: Silverman
mesh_terms: D000818:Animals; D002855:Chromatography, Thin Layer; D004077:Digoxin / Q000378:metabolism* / Q000652:urine; D004285:Dogs; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism*; D007672:Kidney Cortex / Q000378:metabolism; D008297:Male; D008871:Microvilli / Q000378:metabolism
chemical_list: D004077:Digoxin