[Genetic recombination between natural isolates of influenza virus serotypes H1N1 and H3N2].
Oligonucleotide mapping of individual genes was used for search of possible genetic recombinants between natural isolates of influenza H1N1 and H3N2 viruses isolated in the USSR in 1977-1979. No antigenic hybrids and recombinants with the antigenic structure H3N2 were found, however, it was shown that isolates of H1N1 viruses of 1979 (the A/USSR/61/79 strain) might represent genetic recombinants carrying genes P1 + P2 from H3N2 viruses, the M-gene of the USSR/61/79 virus being closest in its structure to the analogous gene of the earliest isolate of H3N2 viruses, namely A/Hong Kong/1/68. Possible selective advantages of virus recombinants having M-genes from viruses of a different serotype are discussed.
Kozlov
Iu V
IuV
Shilov
A A
AA
Chaĭka
O V
OV
Kurmanova
A G
AG
Zhdanov
V M
VM
D005814:Genes, Viral; D053118:Influenza A Virus, H1N1 Subtype; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D009710:Nucleotide Mapping; D009841:Oligonucleotides / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D012703:Serotyping
D009841:Oligonucleotides; D012367:RNA, Viral
Geneticheskaia rekombinatsiia mezhdu prirodnymi izoliatami virusov grippa serotipov H1N1 i H3N2.