Estrogens regulate production of specific growth factors in hormone-dependent human breast cancer.
Human breast cancer cells in long-term tissue culture are responsive to estrogens as assessed by activation of specific gene products. A group of estrogen-regulated, secreted growth factors are responsible for the proliferative responses of these cells both in vitro and in vivo.
Lippman
M E
ME
Bates
S
S
Huff
K K
KK
Davidson
N
N
Dickson
R B
RB
D000911:Antibodies, Monoclonal / Q000276:immunology; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002460:Cell Line; D003470:Culture Media; D066246:ErbB Receptors / Q000032:analysis; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006133:Growth Substances / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis; D007532:Isoleucine / Q000494:pharmacology; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism* / Q000473:pathology; D010452:Peptide Biosynthesis; D015291:Transforming Growth Factors
D000911:Antibodies, Monoclonal; D003470:Culture Media; D004967:Estrogens; D006133:Growth Substances; D007532:Isoleucine; D007334:Insulin-Like Growth Factor I; D015291:Transforming Growth Factors; D066246:ErbB Receptors