Age- and sex-related changes in amine sulphoconjugations in Sprague-Dawley strain rats. Comparison with phenol and alcohol sulphoconjugations.
Age- and sex-related changes in sulphoconjugation were investigated in hepatic 105 000 g supernatants of three-week-old (young), seven-week-old (young adult), one-year-old (middle-aged) and two-year-old (old) Sprague-Dawley rats in the presence of biologically active sulphate. The supernatants of seven-week-old, one-year-old and two-year-old female rats catalysed the sulphoconjugations of alcohol (tiaramide as substrate), and alicyclic amine, alkylamine and arylamine more rapidly than those of the respective males, but the supernatants of three-week-old rats did not exhibit significant sex-related differences. The sulphoconjugations by the supernatants of female rats were substantially constant during ageing. On the other hand, the supernatants of seven-week-old male rats catalysed phenol (beta-naphthol as substrate) sulphoconjugation more rapidly than those of seven-week-old females, but the supernatants of two-year-old rats did not exhibit this sex-related difference. These results indicate that the substrates for sulphoconjugation could be divided into at least two groups: an alcohol and amine type, and a phenol type.
Iwasaki
K
K
Shiraga
T
T
Tada
K
K
Noda
K
K
Noguchi
H
H
D000367:Age Factors; D000438:Alcohols / Q000378:metabolism; D000588:Amines / Q000378:metabolism*; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D052160:Benzothiazoles; D001835:Body Weight; D005260:Female; D008099:Liver / Q000378:metabolism; D008297:Male; D009284:Naphthols / Q000378:metabolism; D010636:Phenols / Q000378:metabolism; D010879:Piperazines / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013431:Sulfates / Q000378:metabolism*; D013466:Sulfurtransferases / Q000378:metabolism
D000438:Alcohols; D000588:Amines; D000814:Aniline Compounds; D052160:Benzothiazoles; D009284:Naphthols; D010636:Phenols; D010879:Piperazines; D013431:Sulfates; C003468:tiaramide; D013466:Sulfurtransferases; C028405:2-naphthol; C023650:aniline