title: The effect of amoxicillin on destructive periodontitis. A case report.
abstract: In a 22-year-old female patient, advanced localized periodontal destruction was observed. The planned treatment consisted of oral hygiene instructions, professional plaque control, deep scaling and root planning and finally modified Widman flap surgery. One molar had to be extracted but was left untreated initially as a control. During the treatment period of 9 months and during 1 year thereafter, samples were taken of the subgingival plaque for dark-field microscopy. The unplanned use of amoxicillin by the patient for a middle ear infection resulted in a suppression below detection level of spirochetes at the investigated sites. At the nontreated control site, the absence of spirochetes was accompanied by a 3-mm reduction of pocket depth and a 2-mm gain in clinical probing attachment, while some formation of new alveolar bone was observed. At the treated sites, clinical improvement was observed. However, a distinction between the effect of the periodontal therapy and the nonscheduled use of amoxicillin could not be made at the treated sites. It is concluded that a single course of systematically administered amoxicillin changed the composition of the subgingival microflora over a long period of time (17 months) and had a beneficial effect upon the status of the periodontium.
authors.forename: M A
authors.initials: MA
authors.lastname: van Oosten
authors.forename: H U
authors.initials: HU
authors.lastname: Hug
authors.forename: F H
authors.initials: FH
authors.lastname: Mikx
authors.forename: H H
authors.initials: HH
authors.lastname: Renggli
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use*; D001419:Bacteria / Q000145:classification / Q000187:drug effects; D018407:Bacterial Physiological Phenomena; D004846:Epithelial Attachment / Q000473:pathology; D005260:Female; D006801:Humans; D010514:Periodontal Pocket / Q000473:pathology / Q000601:surgery / Q000628:therapy; D010518:Periodontitis / Q000601:surgery / Q000628:therapy*; D014092:Tooth Root / Q000601:surgery
chemical_list: D000658:Amoxicillin