[Chemotherapy of renal cell carcinoma. 2. Combined chemotherapy using ACNU and VBL].
Nineteen patients with renal cell carcinoma who had undergone radical nephrectomy have been treated with a combination of chemotherapy and partly hormonal therapy using ACNU, vinblastine and chloromadinone acetate. The efficacy of the combination therapy in advanced renal cell carcinoma was studied and only one out of nineteen cases having lung and pleural metastasis shows no change lasting from one to eighteen months. The prophylactic efficacy was studied in eighteen patients with stage I to IVA renal cell carcinoma (contained one patient with stage IVA renal cell carcinoma who had undergone radical nephrectomy and coecum resection for coecum invasion). Tumor recurrence occurred in 5 cases, that is 5 cases within 1 year and 1 case within 2 years. The combination of chemotherapy using ACNU & vinblastine must be used carefully for severe side effects.
Kobayashi
M
M
Imai
K
K
Nakai
K
K
Kumasaka
F
F
Suzuki
T
T
Ito
Y
Y
Yamanaka
H
H
Sugihara
S
S
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D015376:Nimustine; D009607:Nitrosourea Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D014747:Vinblastine / Q000008:administration & dosage* / Q000009:adverse effects
D009607:Nitrosourea Compounds; D015376:Nimustine; D014747:Vinblastine