ABA-specific responses are I region restricted by the carriers used for immunization.
Immunization of mice with ABA coupled to carriers to which they are nonresponders gives rise to ABA-specific proliferative responses in lymph node cells. When C3H/HeN and CBA/J nonresponder mice are immunized with ABA on (T,G)-A-L (an I-A-restricted carrier in responder mice), the responses to ABA-tyr and ABA coupled to a variety of unrelated carriers are solely I-A restricted as determined by inhibition with anti-IA and anti-I-E sera. When ABA on GLT (an I-E-restricted carrier in responder mice) is used for immunization, the responses are both I-A and I-E restricted. Thus, ABA-specific responses in nonresponder mice appear in part to be restricted by the carrier used for immunization. B10.S mice, lacking functional I-E molecules, channel their ABA-specific responses entirely through I-A when immunized with ABA-GLT. These results support the hypothesis that the failure in nonresponders lies in a functional deficit in the T cell repertoire rather than an inability of accessory cells to present antigen.
Roy
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Gold
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Leskowitz
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D000818:Animals; D001391:Azo Compounds / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology*; D008198:Lymph Nodes; D008213:Lymphocyte Activation; D051379:Mice; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D010455:Peptides / Q000276:immunology; D011108:Polymers; D013045:Species Specificity; D014443:Tyrosine / Q000031:analogs & derivatives / Q000276:immunology; D010132:p-Azobenzenearsonate / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000276:immunology*
D001391:Azo Compounds; D002352:Carrier Proteins; D000949:Histocompatibility Antigens Class II; D010455:Peptides; D011108:Polymers; C022272:glutamic acid-lysine-tyrosine terpolymer; C021759:(T,G)-A-L; C000229:tyrosine-4-azobenzenearsonate; D014443:Tyrosine; D010132:p-Azobenzenearsonate