Recurrent deletion of the short arm of chromosome 3 in human renal cell carcinoma: shift of the c-raf 1 locus.
A cytogenetic study performed on 6 human renal cell carcinomas after short-term culture on extracellular matrix with serum-free medium showed aneuploidy without structural changes in 2 tumors and a rearrangement of the short arm of chromosome 3 in 4 tumors, including deletions and a translocation involving the 3p14 and 3p21 bands. Chromosomal in situ hybridization with a c-raf 1 probe demonstrated that in 2 renal cancers with del3(p14 or 21) the cellular oncogene had shifted from 3p25 to 3p14 as a result of an interstitial deletion.
Teyssier
J R
JR
Henry
I
I
Dozier
C
C
Ferre
D
D
Adnet
J J
JJ
Pluot
M
M
D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D011519:Proto-Oncogenes; D014178:Translocation, Genetic