title: Partial N-terminal sequence analysis of DRw53 antigens: the beta-chains of DRw53 antigens are structurally distinct from beta-chains of DR and DQ antigens.
abstract: DRw53 antigens were isolated from DR7-homozygous and DRw9-homozygous cell lines with an alloantiserum, Hon, containing an anti-DRw53 alloantibody. Partial N-terminal sequence analysis of the isolated DRw53 antigens revealed that DRw53 alpha-chains have sequences indistinguishable from those of DR alpha-chains. In contrast, DRw53 beta-chains have sequences distinct from those of the DR beta-chains and DQ beta-chains isolated from the same cell lines. The DRw53 beta-chains are also distinct from DP beta-chains. These results suggest that the DRw53 beta-chains chains are products of a gene that has not yet been well characterized in the HLA-D region.
authors.forename: F
authors.initials: F
authors.lastname: Obata
authors.forename: T
authors.initials: T
authors.lastname: Endo
authors.forename: G
authors.initials: G
authors.lastname: Tate
authors.forename: N
authors.initials: N
authors.lastname: Miyokawa
authors.forename: M
authors.initials: M
authors.lastname: Katagiri
authors.forename: N
authors.initials: N
authors.lastname: Kashiwagi
mesh_terms: D000595:Amino Acid Sequence; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis* / Q000302:isolation & purification; D006801:Humans
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II