Inhibition of bone resorption in culture by (+)-catechin.
A pretreatment with (+)-catechin renders embryonic mouse calvaria in culture resistant to the action of bone resorbing agents, either parathyroid hormone (PTH), prostaglandin E2 or retinoic acid, and inhibits in a parallel way the enhanced excretion of N-acetyl-beta-glucosaminidase, a reference lysosomal enzyme, induced by these agents; it has, however, no effect on the small spontaneous leakage of lactate dehydrogenase from the explants. Moreover, the resorption induced in calvaria by a pretreatment with PTH or retinoic acid is inhibited by a further culture with catechin. This inhibition of bone resorption is discussed in relation with the collagen-stabilizing properties of (+)-catechin.
Delaissé
J M
JM
Eeckhout
Y
Y
Vaes
G
G
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D001862:Bone Resorption / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism; D002392:Catechin / Q000494:pharmacology*; D015232:Dinoprostone; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D051379:Mice; D009924:Organ Culture Techniques; D010281:Parathyroid Hormone / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D014212:Tretinoin / Q000494:pharmacology
D001578:Benzopyrans; D007527:Isoenzymes; D010281:Parathyroid Hormone; D011458:Prostaglandins E; D014212:Tretinoin; D002392:Catechin; D007770:L-Lactate Dehydrogenase; D015232:Dinoprostone; D002118:Calcium