Chromosomal subclonal evolution in paroxysmal nocturnal hemoglobinuria evolving into acute megakaryoblastic leukemia.
Four cytogenetic studies were performed in the course of a paroxysmal nocturnal hemoglobinuria evolving into acute megakaryoblastic leukemia. The clonal evolution was characterized by a unique structural change (9p) at the time of diagnosis, heralding an accelerated and complex karyotypic alteration including 5q-, 12p-, +21, -5, -7. At the terminal phase, the initial population was replaced within 1 week by a new overgrowing clone with -5, +8, +17. This suggests that the paroxysmal nocturnal hemoglobinuria-associated preleukemia and leukemic states share with acute nonlymphocytic leukemia the same nonrandom chromosomal changes.
Teyssier
J R
JR
Pigeon
F
F
Behar
C
C
Pignon
B
B
Blaise
A M
AM
D000328:Adult; D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002999:Clone Cells; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D007947:Leukemia, Megakaryoblastic, Acute / Q000209:etiology / Q000235:genetics*; D011289:Preleukemia / Q000235:genetics; D013997:Time Factors