Intake of a liquid diet after 2-deoxy-D-glucose injections in rats.
The effects of a liquid diet after 2-deoxy-D-glucose (2DG) were examined following water deprivation, after food deprivation, and at longer post-injection intervals when animals reportedly are hypophagic as a function of drug treatment. Water deprived rats were unable to increase their post-drug feeding when ingesting the liquid diet; and in food deprived subjects, intake patterns of liquid diet and of lab chow pellets were essentially identical after 2DG. The tendency of a 750 mg/kg dosage to produce a longer-term hypophagic reaction was more evident in animals given pellets instead of the liquid diet. While previous studies have found the liquid diet to promote 2DG-induced feeding in lesioned subjects, the present data demonstrate that such facilitation effects do not invariably occur during post-drug conditions in which animals are inhibited in their intake.
Watson
P J
PJ
Rhodes
D H
DH
Rhea
K
K
McKinney
J
J
Hawkins
C
C
Bartles
R R
RR
D000818:Animals; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D002149:Energy Intake / Q000187:drug effects*; D001068:Feeding and Eating Disorders / Q000139:chemically induced; D005508:Food Deprivation; D005526:Food, Formulated; D008297:Male; D051381:Rats; D014868:Water Deprivation
D003837:Deoxy Sugars; D003847:Deoxyglucose