title: Mucosal IgA production and lymph cell traffic following prolonged low level infections of Ostertagia circumcincta in sheep.
abstract: Some aspects of the local immune response to daily challenge with 2000 Ostertagia circumcincta larvae were studied by monitoring changes in the composition of gastric lymph of naive and previously infected sheep. The main changes in the naive group were increases in lymphoblast output and concentrations of pepsinogen whereas lymph albumin values decreased markedly and IgA concentrations were usually unchanged. In contrast, in the previously infected sheep, the continuous challenge stimulated only transient increases in lymphoblast and IgA containing cell traffic whereas lymph IgA and pepsinogen concentrations remained elevated throughout the experiment. By temporarily interrupting the challenge in a second group of previously infected sheep it was shown that elevated IgA and pepsinogen values were maintained only if larval intake was continuous.
authors.affiliation: Moredun Research Institute, Edinburgh.
authors.forename: W D
authors.initials: WD
authors.lastname: Smith
authors.forename: F
authors.initials: F
authors.lastname: Jackson
authors.forename: R
authors.initials: R
authors.lastname: Graham
authors.forename: E
authors.initials: E
authors.lastname: Jackson
authors.forename: J
authors.initials: J
authors.lastname: Williams
mesh_terms: D000018:Abomasum / Q000378:metabolism; D000818:Animals; D005753:Gastric Mucosa / Q000378:metabolism*; D007070:Immunoglobulin A / Q000032:analysis / Q000096:biosynthesis*; D008196:Lymph / Q000032:analysis* / Q000166:cytology / Q000276:immunology; D010029:Ostertagiasis / Q000276:immunology / Q000662:veterinary*; D010435:Pepsinogens / Q000032:analysis; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000469:parasitology; D014252:Trichostrongyloidiasis / Q000662:veterinary*
chemical_list: D007070:Immunoglobulin A; D010435:Pepsinogens