title: Myelodysplasia progressing to acute myeloblastic leukemia in an HTLV-III virus-positive homosexual man with AIDS-related complex.
abstract: Myelodysplastic changes have recently been described in patients with the acquired immunodeficiency syndrome (AIDS). The authors report a patient with AIDS-related complex and myelodysplasia who rapidly progressed to acute myeloblastic leukemia. Infection with human T-cell lymphotropic virus type III (HTLV-III) was documented by culture and by serology. Chromosome studies showed monosomy of chromosome 7 and structural abnormality of the long arm of chromosome 3. The association of HTLV-III infection with myelodysplasia and acute myeloblastic leukemia may have been coincidental in this reported case, but it is also possible that the leukemia was secondary to the HTLV-III infection. Further investigation appears justified.
authors.forename: V M
authors.initials: VM
authors.lastname: Napoli
authors.forename: S F
authors.initials: SF
authors.lastname: Stein
authors.forename: T J
authors.initials: TJ
authors.lastname: Spira
authors.forename: D
authors.initials: D
authors.lastname: Raskin
mesh_terms: D000386:AIDS-Related Complex / Q000150:complications* / Q000382:microbiology; D000328:Adult; D006678:HIV / Q000302:isolation & purification*; D006716:Homosexuality; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications*