title: Spatial and temporal relationships between cell death and tissue overgrowth in imaginal wing disks of the Drosophila mutant l(3)c43hs1.
abstract: The temperature-sensitive mutant l(3)c43hs1 is lethal at the restrictive temperature late in the last larval instar and has wing disks that show excessive growth when larvae are reared at 25 degrees C. Such mutant disks give rise to defective wings showing duplications and deficiencies. Abnormal folding patterns are localized to the region between the wing pouch and the area where adepithelial cells are found; the disks retain an epithelial morphology. Apoptotic cell death is distributed throughout the wing disks without any obvious concentration of dead cells in a specific area. Cell death is seen as early as 12 hr after a shift to the restrictive temperature. Temperature shift experiments also show that cell death precedes the onset of overgrowth, but since the spatial distribution of death is not localized to the regions of abnormal folds, it is unlikely that cell death and overgrowth are causally related.
authors.affiliation: Developmental Biology Center, University of California, Irvine 92717.
authors.forename: B J
authors.initials: BJ
authors.lastname: Sedlak
mesh_terms: D000818:Animals; D002470:Cell Survival; D004330:Drosophila / Q000033:anatomy & histology / Q000166:cytology / Q000235:genetics*; D007814:Larva; D008854:Microscopy, Electron; D009154:Mutation; D014921:Wings, Animal / Q000166:cytology / Q000648:ultrastructure