Cytosol estradiol receptor content in the adult rat brain after neonatal treatment with estradiol benzoate or testosterone propionate.
The effects of neonatal treatment with estrogen or androgen on the development of cytosol estradiol (E2) receptors were examined in the rat pituitary, hypothalamus and amygdala. The treatment with estradiol benzoate (EB, 100 micrograms) significantly reduced the E2 receptor content in all of these regions in both sexes. But the treatment with testosterone propionate (TP, 1 mg) to the female rats significantly decreased the E2 receptor content in the pituitary and hypothalamus but not in the amygdala. The TP treatment to the male rats decreased the E2 receptor content in the hypothalamus and amygdala but not in the pituitary. The decreased cytosol E2 receptors in the hypothalamus and amygdala seem to be implicated in preventing the normal sexual development.
Takeshita
H
H
Department of Neuropsychiatry, Tottori University School of Medicine, Yonago, Japan.
Shimizu
K
K
Hazama
H
H
D000679:Amygdala / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects*; D003600:Cytosol / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007031:Hypothalamus / Q000187:drug effects; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011959:Receptors, Estradiol / Q000187:drug effects*; D011960:Receptors, Estrogen / Q000187:drug effects*; D012741:Sexual Maturation / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*
D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D013739:Testosterone; D004958:Estradiol