In vitro and in vivo effect of organophosphate pesticides on monoamine oxidase activity in rat brain.
The effects of some organophosphate pesticides, e.g. lebaycid, metacid and metasystox on the monoamine oxidase (MAO) activity in rat brain mitochondria have been studied. These pesticides cause significant inhibition of MAO activity in vitro but have negligible effects on its activity in vivo.
Nag
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M
Indian Institute of Chemical Biology, Calcutta.
Nandi
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N
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D066298:In Vitro Techniques; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010575:Pesticides / Q000633:toxicity*; D051381:Rats; D013347:Subcellular Fractions / Q000187:drug effects / Q000201:enzymology
D009943:Organophosphorus Compounds; D010575:Pesticides; D008995:Monoamine Oxidase