Spontaneous regression of cytogenetic and haematologic anomalies in Ph1-positive chronic myelogenous leukaemia.
We report a case of a 27-year-old man with Ph1-positive chronic myelogenous leukaemia (CML). At the time of diagnosis 100% Ph1-positive cells were found with a trisomy 8 in 50% of them. In absence of therapy, his haematological status remained stable for 3 years. Subsequently a progressive regression of haematologic and cytogenetic data was observed. Eight years after diagnosis the karyotype showed only 37% Ph1-positive cells and the trisomy 8 had disappeared.
Smadja
N
N
Krulik
M
M
Audebert
A A
AA
de Gramont
A
A
Debray
J
J
D000328:Adult; D002906:Chromosomes, Human, 6-12 and X; D005500:Follow-Up Studies; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000097:blood / Q000235:genetics*; D008297:Male; D009365:Neoplasm Regression, Spontaneous; D010677:Philadelphia Chromosome; D014314:Trisomy