Evidence for methoxatin (pyrroloquinolinequinone) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy.
Resonance Raman spectra of the 2,4-dinitrophenylhydrazine derivatives of bovine plasma amine oxidase [amine:oxygen oxidoreductase (deaminating) (copper-containing), EC 1.4.3.6] have been measured. Detailed comparisons to the spectra of the corresponding derivatives of methoxatin (pyrroloquinolinequinone), pyridoxal, and other aldehydes and diones provide further evidence that covalently bound methoxatin or a closely similar derivative is the organic cofactor in copper-containing amine oxidases.
Moog
R S
RS
McGuirl
M A
MA
Cote
C E
CE
Dooley
D M
DM
D006631:Amine Oxidase (Copper-Containing); D000818:Animals; D002417:Cattle; D006835:Hydrazones; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000097:blood*; D045542:PQQ Cofactor; D011730:Pyridoxal; D011804:Quinolines / Q000032:analysis*; D013059:Spectrum Analysis, Raman
C001072:2,4-dinitrophenylhydrazone; D006835:Hydrazones; D011804:Quinolines; D011730:Pyridoxal; D045542:PQQ Cofactor; D006631:Amine Oxidase (Copper-Containing); D000587:Oxidoreductases Acting on CH-NH Group Donors