title: Detection of TdT in AML blasts by immunological and biochemical techniques.
abstract: The cellular level of terminal deoxynucleotidyl transferase (TdT) was measured in blasts from patients with AML. Parallel determinations were made using an immunoassay and polymerizing reaction. There was a good correlation between the two techniques (r = 0.92) and detectable levels of the enzyme was found in approximately 50% of the cases. The TdT levels found in AML blasts were 1/10 - 1/100 of that reported for cells of lymphoid origin.
authors.forename: L
authors.initials: L
authors.lastname: Skoog
authors.forename: T
authors.initials: T
authors.lastname: Hägerström
authors.forename: P
authors.initials: P
authors.lastname: Reizenstein
authors.forename: A
authors.initials: A
authors.lastname: Ost
mesh_terms: D004253:DNA Nucleotidylexotransferase / Q000032:analysis* / Q000276:immunology; D004254:DNA Nucleotidyltransferases / Q000032:analysis*; D006801:Humans; D007118:Immunoassay; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology*; D011108:Polymers / Q000032:analysis
chemical_list: D011108:Polymers; D004254:DNA Nucleotidyltransferases; D004253:DNA Nucleotidylexotransferase