[The antibiotic galtamycin. Its fermentation, isolation, physicochemical and biological properties].
A culture of Streptomyces sp., producing an antibiotic named galtamycin was isolated from a soil sample collected in the Gorno-Altai Autonomous Region. The antibiotic belongs to anthracyclines. Biosynthesis, isolation, physico-chemical and biological properties of the antibiotic are described. The studies showed that galtamycin consisting of a chromophore and three unidentified sugars is a new compound differing from the known anthracyclines except trypanomycin by the absence of the UV absorption maximum at 230-240 nm. Galtamycin differs from trypanomycin by the molecular weight of the chromophore. Galtamycin showed low antitumor activity and was inactive against grampositive and gramnegative organisms and fungi.
Korobkova
T P
TP
Singal
E M
EM
Ivanitskaia
L P
LP
Kudinova
M K
MK
Karbyshev
V D
VD
D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004353:Drug Evaluation, Preclinical; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D009279:Naphthacenes / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D009374:Neoplasms, Experimental / Q000188:drug therapy; D012988:Soil Microbiology; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000201:enzymology
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; C049641:galtamycin
Antibiotik galtamitsin. Fermentatsiia, vydelenie, fizikokhimicheskie i biologicheskie svoĭstva.