A myelodysplastic syndrome with marrow eosinophilia terminating in acute nonlymphocytic leukemia, associated with an abnormal chromosome 16.
A patient presented with a myelodysplastic syndrome and bone marrow eosinophilia that evolved six months later into an acute nonlymphocytic leukemia (ANLL). Cytogenetic analyses of the bone marrow revealed 86% of the metaphases with 45,X-Y,inv(16)(p13;q22),t(11;17) (q11;q25),del(21)(q13) and 14% of the metaphases with the same abnormalities but with a Y chromosome. The association of ANLL, bone marrow eosinophilia, and abnormal chromosome 16 has previously been reported and has been suggested to have a favorable prognosis. Our patient is unique in that ANLL was preceded by a preleukemic phase associated with bone marrow eosinophilia. When complete remission was achieved, the bone marrow cytogenetics returned to normal, and the eosinophilia disappeared.
Abbondanzo
S L
SL
Gray
R G
RG
Whang-Peng
J
J
Jacobson
R J
RJ
D001853:Bone Marrow / Q000473:pathology; D001855:Bone Marrow Diseases / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure*; D004802:Eosinophilia / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000473:pathology; D014998:Y Chromosome / Q000648:ultrastructure