title: The influence of various substances on the gliding motility of Mycoplasma mobile 163K.
abstract: Non-toxic concentrations of various substances were tested for their influence on the gliding motility of Mycoplasma mobile 163K. A significant inhibitory effect on motility was observed with agents acting on nucleic acid synthesis (mitomycin), protein synthesis (puromycin, chloramphenicol), energy metabolism (p-chloromercuribenzoate, iodoacetate) and with compounds reacting with the cytoplasmic membrane or contractile elements (albumin, cholesterol, EDTA, 2-propanol, procain, CaCl2, MgCl2, colchicin and KI). The surface-active compounds Triton X-100, Tego and SDS increased the gliding velocity significantly in some concentrations and incubation periods. The results suggest that the motility of M. mobile depends on a functional cytoplasmic membrane and that cytoskeletal elements are involved in the gliding mechanism.
authors.affiliation: Institut für Mikrobiologie und Tierseuchen, Tierärztliche Hochschule Hannover, FRG.
authors.forename: B
authors.initials: B
authors.lastname: Piper
authors.forename: R
authors.initials: R
authors.lastname: Rosengarten
authors.forename: H
authors.initials: H
authors.lastname: Kirchhoff
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects; D008854:Microscopy, Electron; D009174:Mycoplasma / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure
chemical_list: D000900:Anti-Bacterial Agents