Cytochalasin D suppresses sound evoked potentials in the guinea pig cochlea.
Cytochalasin D (CD), an inhibitor of actin polymerization, was perfused through the guinea pig cochlea while monitoring various cochlear potentials. CD (10(-7)-10(-5) M) reduced the magnitude of the compound action potential of the cochlear nerve and the summating potential, and increased N1 latency. The cochlear microphonic potential was the least sensitive potential with only a slight effect being observed at 10(-5) M. The results are consistent with the hypothesis that actin has a role in cochlear function.
Barron
S E
SE
Tulane Medical School, Dept. of Pharmacology, New Orleans, Louisiana.
Bobbin
R P
RP
Guth
P
P
Norris
C
C
D000199:Actins / Q000037:antagonists & inhibitors; D000818:Animals; D003051:Cochlea / Q000187:drug effects* / Q000502:physiology; D003055:Cochlear Microphonic Potentials / Q000187:drug effects*; D015638:Cytochalasin D; D003572:Cytochalasins / Q000494:pharmacology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D008297:Male
D000199:Actins; D003572:Cytochalasins; D015638:Cytochalasin D