title: Percentage of S-phase cells in bone marrow aspirates, biopsy specimens and bone marrow aspirates corrected for blood dilution from patients with acute leukemia.
abstract: For 14 patients with acute leukemia flow cytometry was used to determine the percentage of cells in S-phase flushed out of a bone marrow biopsy compared with the percentage in a bone marrow aspirate; there was a statistically significant difference (p less than 0.01) between the two. The percentage dilution of the bone marrow aspirate by peripheral blood was then calculated, according to Holdrinet et al. [1], in order to correct the percentage S-phase cells in the aspirate. The data presented show that when the percentage S-phase cells in the aspirate is corrected for blood dilution, it closely approaches the percentage S-phase cells in the biopsy (p greater than 0.10).
authors.forename: L P
authors.initials: LP
authors.lastname: Colly
authors.forename: W G
authors.initials: WG
authors.lastname: Peters
authors.forename: J
authors.initials: J
authors.lastname: Hermans
authors.forename: W
authors.initials: W
authors.lastname: Arentsen-Honders
authors.forename: R
authors.initials: R
authors.lastname: Willemze
mesh_terms: D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D005434:Flow Cytometry; D006801:Humans; D007399:Interphase; D007945:Leukemia, Lymphoid / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*