[Substantiation and effectiveness of the use of purine antagonists in gouty nephropathy].
Similarity of the morphological picture of gouty nephropathy and primary glomerulonephritides in which purine antagonists turned out to be effective, a positive effect of azathioprine (Az) and 6-mercaptopurine (MP) on purine metabolism, and changes in immunity indices revealed in gout (hyperproduction of immunoglobulins and circulating immune complexes) necessitates the use of antimetabolites in combined therapy of gout patients with proteinuric and latent types of nephropathy. A prolonged use of Az and MP at a daily dose of 50-100 mg often leads to the recovery or improvement of lowered renal function, disappearance of the urinary syndrome, and suppression of hyperuricemia. Uricosuppressors without purine antagonists produce a weaker effect on the course of a renal process, and the treatment of such patients without the use of basic drugs has proved to be utterly ineffective. Strict control over Az and MP therapy makes side-effects of the drugs rare, and they can be easily done away with after reducing a drug dose.
Siniachenko
O V
OV
Diadyk
A I
AI
Nikolenko
Iu I
IuI
Vasilenko
I V
IV
Shpilevaia
N I
NI
D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006073:Gout / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000188:drug therapy*; D015122:Mercaptopurine / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D013997:Time Factors; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D015122:Mercaptopurine; D001379:Azathioprine
Obosnovanie i éffektivenost' primeneniia antagonistov purina pri podagricheskoĭ nefropatii.