Cardiovascular effects of magnesium sulphate in the baboon.
The effect of Mg infusions on cardiovascular function were investigated in 6 adult male chacma baboons over a wide range of serum Mg concentrations. There was a dose-dependent reduction in systemic vascular resistance which correlated well with serum Mg levels (r = -0.67; p less than 0.001), but arterial blood pressure was only moderately affected at serum Mg levels below 5 mmol/l. Heart rate was reduced at serum Mg concentrations above 5 mmol/l. Cardiac output and stroke work were increased at all Mg levels up to 5 mmol/l, and stroke volume increased significantly until the serum Mg level exceeded 7 mmol/l. Central venous pressure and pulmonary capillary wedge pressure were not affected by increasing magnesium levels, and there was no evidence of myocardial depression at any level of serum Mg.
James
M F
MF
Department of Anaesthesia, University of the Witwatersrand, Johannesburg, South Africa.
Cork
R C
RC
Dennett
J E
JE
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007262:Infusions, Intravenous; D008274:Magnesium / Q000097:blood; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010215:Papio; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D008278:Magnesium Sulfate; D008274:Magnesium; D002118:Calcium