Effect of prostaglandin D2 on histamine-induced weals in human skin.
The effect of prostaglandin D2 (PGD2) on weal response to intradermal injection of histamine was examined in normal volunteers. Co-injection of variable amounts of PGD2 with a fixed dose of histamine (2.5 nmol) was made so that the molar ratio of histamine: PGD2 covered the range 15 to 1215. There was no significant effect of PGD2 on weal area. PGD2, present at a 50 times lower concentration than histamine, had no effect on either the dose-response curves for the histamine-induced weal area or the forearm weal volume response to 2.5 nmol histamine. It is concluded that PGD2, when present at the relative amounts found in vitro and in vivo, has no effect on the weal response to histamine in man.
Barnes
V F
VF
Heavey
D J
DJ
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D007428:Intradermal Tests; D008297:Male; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000494:pharmacology*; D012882:Skin Tests
D011457:Prostaglandins D; D006632:Histamine; D015230:Prostaglandin D2