[Fluorescence cytophotometric DNA studies of Ewing and osteosarcomas].
The single-cell fluorescence cytometric data presented in this study basing on measurements on 6 osseous Ewing's-Sarcoma and 17 classical osteosarcoma are showing a mirrorlike behaviour to cytological and histological appearance. The cellular monotony in Ewing's-Sarcoma and the polymorphic appearance of osteosarcoma are represented by typical aneuploid DNA-histograms. Ewing's-Sarcoma histogram's show a large peak between the diploid and tetraploid region and little deviation to the octoploid value. The conventional osteosarcomas are characterised by a very polyploid and changeable DNA-histogram with variable blocks and peaks and deviation up to 34c. Special trends in the subtypes are remarkable, but depend on further investigations. DNA-measurements support objectivization of histological appearance on the one hand and the controlling of therapeutical responses on the other hand.
Frohn
A
A
Födisch
H J
HJ
Bode
U
U
D000293:Adolescent; D000671:Amputation, Surgical; D000782:Aneuploidy; D001706:Biopsy; D001859:Bone Neoplasms / Q000473:pathology* / Q000628:therapy; D001842:Bone and Bones / Q000473:pathology; D002648:Child; D003131:Combined Modality Therapy; D003592:Cytophotometry; D004273:DNA, Neoplasm / Q000378:metabolism*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D012516:Osteosarcoma / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012512:Sarcoma, Ewing / Q000473:pathology* / Q000628:therapy
D004273:DNA, Neoplasm
Fluoreszenzzytophotometrische DNS-Studien an Ewing- und Osteosarkomen.