Immunoregulating activity of tumor-associated macrophages.
In this report, we examine the antigen nonspecific immunoregulating activity of macrophages isolated from the murine methylcholanthrene-induced fibrosarcoma FSA. These cells were shown to enhance the primary anti-CRBC PFC response of whole normal spleen cells in a dose-dependent fashion. This function was associated with a subpopulation of large Ia-negative macrophages and was mediated by a soluble macrophage-derived factor that appeared to act by stimulating the proliferation and/or differentiation of antigen-reactive T cells. The relationship of this factor to previously described monokines is discussed.
Dougherty
G J
GJ
McBride
W H
WH
D000818:Animals; D002469:Cell Separation; D003470:Culture Media; D005354:Fibrosarcoma / Q000139:chemically induced / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008809:Mice, Inbred C3H; D010529:Peritoneal Cavity / Q000166:cytology; D012513:Sarcoma, Experimental / Q000276:immunology*; D013154:Spleen / Q000166:cytology
D003470:Culture Media; D000949:Histocompatibility Antigens Class II; D008748:Methylcholanthrene