[Vitamin E deficiency in cystic fibrosis].
Plasma vitamin E levels were measured by high performance liquid chromatography in 42 children with cystic fibrosis and were correlated with the following parameters: sex, age, time of follow-up, clinical evolution (Schwachman score), vitamin E/cholesterol and faecal fat excretion. All children in this study received oral alfa-tocoferol (50-100 mg daily) from the diagnosis. According to the vitamin E level patients were distributed in two groups. Group I: 27 patients (64.3%) with normal concentrations. Group II: 15 patients (35.7%) with decreases plasma levels but without clinical manifestations. Steatorrhea was present in all children except 4 patients from group I and one patient from group II. On the other hand, vitamin E/cholesterol was normal in 80% of patients with vitamin E deficiency (group II). We did not find any correlation between plasma vitamin E levels and the different clinical and biological parameters studied. Further studies should be carried out to throw more light on the mechanism underlying the pathogenesis of vitamin E deficiency in patients with cystic fibrosis.
Muñoz
C
C
Unidad de Gastroenterología y Nutrición, Hospital Infantil La Paz, Facultad de Medicina, Universidad Autónoma, Madrid.
Polanco
I
I
Hernanz
A
A
Carrasco
S
S
Barea
I
I
Murga
M L
ML
Arroba
M L
ML
Codoceo
R
R
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003550:Cystic Fibrosis / Q000097:blood* / Q000150:complications; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D008055:Lipids / Q000032:analysis; D008297:Male; D014810:Vitamin E / Q000032:analysis / Q000097:blood*; D014811:Vitamin E Deficiency / Q000209:etiology*
D008055:Lipids; D014810:Vitamin E; D002784:Cholesterol
Deficiencia de vitamina E en la fibrosis quística.