title: Diffusion of ofloxacin into the cerebrospinal fluid in patients with bacterial meningitis.
abstract: Ofloxacin diffusion into cerebrospinal fluid (CSF) was evaluated in nine patients with bacterial meningitis. Patients were under treatment with i.v. amoxicillin (100 mg/kg/day), and during the first five days they were also given oral ofloxacin, 200 mg b.i.d. On days 2 and 5, blood and CSF samples were collected for assays by both HPLC and microbiological techniques. Samples were obtained 2 h (n = 2), 4 h (n = 1), 6 h (n = 2), 8 h (n = 2) and 12 h (n = 2) after the ofloxacin dose respectively. Concentration in CSF was 50 to 60% of that in serum and there was no significant difference between results with the two assay techniques.
authors.forename: J P
authors.initials: JP
authors.lastname: Stahl
authors.forename: J
authors.initials: J
authors.lastname: Croize
authors.forename: M A
authors.initials: MA
authors.lastname: Lefèbvre
authors.forename: J P
authors.initials: JP
authors.lastname: Bru
authors.forename: A
authors.initials: A
authors.lastname: Guyot
authors.forename: D
authors.initials: D
authors.lastname: Leduc
authors.forename: J B
authors.initials: JB
authors.lastname: Fourtillan
authors.forename: M
authors.initials: M
authors.lastname: Micoud
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000134:cerebrospinal fluid*; D001424:Bacterial Infections / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid*; D008585:Meningitis, Meningococcal / Q000134:cerebrospinal fluid; D008586:Meningitis, Pneumococcal / Q000134:cerebrospinal fluid; D015242:Ofloxacin; D010078:Oxazines / Q000134:cerebrospinal fluid*
chemical_list: D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin