title: Karyotype evolution in CML: high frequency of translocations other than the Ph.
abstract: The karyotypes of 33 Philadelphia-positive chronic myelogenous leukemia patients during the blastic phase are reported. Only three patients (9%) had a Philadelphia clone without further chromosomal aberrations, whereas, all the others had karyotype evolution. Aside from some nonrandom abnormalities (+8, i(17q), +Ph, +19) we found a higher frequency of clones with random structural rearrangements (13 cases, 39.4%) than previously reported. From a clinical point of view, however, the additional chromosomal (structural) abnormalities do not significantly influence the patients' survival.
authors.forename: M
authors.initials: M
authors.lastname: Sessarego
authors.forename: C
authors.initials: C
authors.lastname: Panarello
authors.forename: D A
authors.initials: DA
authors.lastname: Coviello
authors.forename: P
authors.initials: P
authors.lastname: Boccaccio
authors.forename: F
authors.initials: F
authors.lastname: Ajmar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001752:Blast Crisis; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic
chemical_list: D005819:Genetic Markers