Protein synthesis in the tumour-bearing rat.
The rates of protein synthesis in liver, muscle and tumour of animals bearing either a rapidly growing (7288c) or slow-growing (5123c) hepatoma were determined. Liver protein synthesis was increased whilst, in contrast, protein synthesis in muscle decreased. Tumour protein synthesis comprised between 15% and 43% of total body protein synthesis. Since food intake of tumour-bearing animals was not significantly different from that of controls, these changes were not attributable to an anorexic component of the tumour-bearing state but may reflect a systemic tumour-mediated effect.
Paxton
K
K
Department of Biochemistry, University of Queensland, St. Lucia, Australia.
Ward
L C
LC
Wilce
P A
PA
D000818:Animals; D001835:Body Weight; D008099:Liver / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D008297:Male; D009124:Muscle Proteins / Q000096:biosynthesis; D009132:Muscles / Q000378:metabolism; D009363:Neoplasm Proteins / Q000096:biosynthesis; D014176:Protein Biosynthesis; D051381:Rats
D009124:Muscle Proteins; D009363:Neoplasm Proteins