title: Spontaneous cure of end-stage acute nonlymphocytic leukemia complicated with chloroma (granulocytic sarcoma).
abstract: Spontaneous regression of end-stage acute nonlymphocytic leukemia (ANLL) complicated with chloroma (granulocytic sarcoma) was observed in a child after the patient had been sent home for terminal care. The patient was initially found to have the 8;21 translocation and has survived without any evidence of disease 101 months after the initial diagnosis and 80 months after the discontinuation of all therapy. Spontaneous regression of a wide variety of tumors has been reported, but this observed case has no features in common with those cases. Special implications of this case are discussed.
authors.forename: Y
authors.initials: Y
authors.lastname: Takaue
authors.forename: S J
authors.initials: SJ
authors.lastname: Culbert
authors.forename: J
authors.initials: J
authors.lastname: van Eys
authors.forename: W T
authors.initials: WT
authors.lastname: Dalton
authors.forename: A
authors.initials: A
authors.lastname: Cork
authors.forename: J M
authors.initials: JM
authors.lastname: Trujillo
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology / Q000648:ultrastructure; D002648:Child; D004317:Doxorubicin / Q000627:therapeutic use; D005134:Eye Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000188:drug therapy / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D009296:Nasal Cavity / Q000473:pathology; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary; D010255:Paranasal Sinus Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D014178:Translocation, Genetic
chemical_list: D004317:Doxorubicin