title: Loss of HLA-A,B,C in colorectal carcinoma is related to the degree of de-differentiation.
abstract: By means of immunoperoxidase staining of frozen sections 100 primary colorectal carcinomas and 19 metastases were studied for the expression of HLA-A,B,C antigens. A substantial number of the tumours showed a deficient class I expression. The loss of HLA-A,B,C correlated with the degree of de-differentiation.
authors.forename: F
authors.initials: F
authors.lastname: Momburg
authors.forename: P
authors.initials: P
authors.lastname: Möller
authors.forename: G
authors.initials: G
authors.lastname: Moldenhauer
authors.forename: G J
authors.initials: GJ
authors.lastname: Hämmerling
mesh_terms: D002454:Cell Differentiation; D003110:Colonic Neoplasms / Q000276:immunology* / Q000473:pathology; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006801:Humans; D012004:Rectal Neoplasms / Q000276:immunology* / Q000473:pathology
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens