title: Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro.
abstract: The development of drug resistance by tumor cells is a major obstacle to the cure of human malignancy. Cyclosporin A (CsA) completely reverses primary resistance to vincristine and cross resistance to daunorubicin in a pleiotropic drug-resistant subline of human T cell acute lymphatic leukemia. This subline is over 50-fold resistant to vincristine and fivefold resistant to daunorubicin. CsA has little effect on vincristine or daunorubicin activity in drug-sensitive parental leukemia and corrects daunorubicin resistance without altering cellular daunorubicin accumulation.
authors.forename: L M
authors.initials: LM
authors.lastname: Slater
authors.forename: P
authors.initials: P
authors.lastname: Sweet
authors.forename: M
authors.initials: M
authors.lastname: Stupecky
authors.forename: S
authors.initials: S
authors.lastname: Gupta
mesh_terms: D002460:Cell Line; D003524:Cyclosporins / Q000627:therapeutic use*; D003630:Daunorubicin / Q000627:therapeutic use*; D004351:Drug Resistance; D004357:Drug Synergism; D066298:In Vitro Techniques; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D014750:Vincristine / Q000627:therapeutic use*
chemical_list: D003524:Cyclosporins; D014750:Vincristine; D003630:Daunorubicin