title: Altered cerebral vessel innervation in spontaneously hypertensive and renal hypertensive rats.
abstract: The ultrastructural distributions of sympathetic and non-sympathetic nerve terminals in cerebral arteries of normotensive Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR) and one-kidney, one clip renal hypertensive rats (RHR) were examined. When compared with WKY, the SHR cerebral arteries receive denser sympathetic nerve terminals and fewer non-sympathetic nerve terminals. On the other hand, both sympathetic and non-sympathetic nerve terminals decrease in the cerebral arteries of RHR. These results suggest that the sympathetic vasoconstriction may surpass the non-sympathetic vasodilation in some brain regions of SHR, while the functional significance of cerebral sympathetic vasoconstrictor and non-sympathetic vasodilator nerves may decrease in RHR. The pattern of cerebral vessel innervation differs in different types of hypertension.
authors.forename: T J
authors.initials: TJ
authors.lastname: Lee
authors.forename: A
authors.initials: A
authors.lastname: Saito
mesh_terms: D000818:Animals; D002536:Cerebral Arteries / Q000294:innervation*; D006973:Hypertension / Q000235:genetics / Q000473:pathology*; D006978:Hypertension, Renovascular / Q000473:pathology*; D009411:Nerve Endings / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains / Q000033:anatomy & histology*; D013564:Sympathetic Nervous System / Q000648:ultrastructure*