title: A phase II study of high-dose cytosine arabinoside in the treatment of acute leukaemia in adults.
abstract: Twenty-seven adults with refractory or recurrent acute leukaemia were treated with cytosine arabinoside (ara-C) 2 g/m2 infused over 3 h, every 12 h for 6 days, either alone (regimen A) or with vincristine and prednisolone (regimen B). Complete remission was achieved in 9/18 patients (5/12 regimen A, 4/6 regimen B) with acute lymphoblastic leukaemia (ALL), 1/7 patients (1/5 regimen A) with lymphoid blast crisis of chronic myeloid leukaemia (CML.LBC) and 1/2 patients (1/1 regimen B) with acute undifferentiated leukaemia (AUL). A further 5 patients (4 regimen A, 1 regimen B) with ALL, 4 patients (3 regimen A, 1 regimen B) with CML.LBC and 1 patient (regimen A) with AUL showed evidence of significant response. These results confirm the activity of high-dose a-ra-C in acute non-myelogenous leukaemia and suggest that it might be used with benefit to intensify the initial treatment of 'poor-risk' ALL.
authors.forename: M J
authors.initials: MJ
authors.lastname: Barnett
authors.forename: A Z
authors.initials: AZ
authors.lastname: Rohatiner
authors.forename: T S
authors.initials: TS
authors.lastname: Ganesan
authors.forename: M A
authors.initials: MA
authors.lastname: Richards
authors.forename: A
authors.initials: A
authors.lastname: Miller
authors.forename: T A
authors.initials: TA
authors.lastname: Lister
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001752:Blast Crisis / Q000188:drug therapy; D003561:Cytarabine / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D013997:Time Factors
chemical_list: D003561:Cytarabine