Effect of cis-platinum treatment on 67Ga-citrate localization and elimination in rabbits.
The treatment of rabbits with a typical dosage schedule of the chemotherapeutic drug cis-platinum resulted in an increased whole body retention of 67Ga-citrate due to decreased urinary and fecal excretion. The biodistribution of the tracer was also affected with most tissues showing greater accumulation. These changes are primarily related to drug-induced renal dysfunction, but other factors may also be involved.
Sykes
T R
TR
Noujaim
A A
AA
Stephens-Newsham
L G
LG
Lentle
B C
BC
Turner
A R
AR
Ng
P K
PK
Hooper
H R
HR
D000818:Animals; D002945:Cisplatin / Q000378:metabolism / Q000494:pharmacology*; D005243:Feces / Q000032:analysis; D005260:Female; D005710:Gallium Radioisotopes / Q000378:metabolism* / Q000652:urine; D008297:Male; D011817:Rabbits; D013997:Time Factors; D014018:Tissue Distribution
D005710:Gallium Radioisotopes; D002945:Cisplatin