title: Oral complications of multimodality therapy for advanced squamous cell carcinoma of head and neck.
abstract: Investigational treatment of advanced localized stage III or stage IV squamous cell carcinoma of the head and neck may include chemotherapy in addition to radiotherapy and surgery. Such therapy, while effective in eradicating local tumors, often produces considerable oral toxicity. In this study we reviewed the oral complications of 22 patients receiving multimodality cancer treatment. The addition of chemotherapy to the treatment regimen did not increase the incidence of complications (osteoradionecrosis, mucositis, xerostomia, radiation caries, or infection) when compared with historical controls receiving radiotherapy alone. Pretreatment dental evaluation and close follow-up of these patients are encouraged.
authors.forename: D
authors.initials: D
authors.lastname: Archibald
authors.forename: P B
authors.initials: PB
authors.lastname: Lockhart
authors.forename: S T
authors.initials: ST
authors.lastname: Sonis
authors.forename: T J
authors.initials: TJ
authors.lastname: Ervin
authors.forename: B G
authors.initials: BG
authors.lastname: Fallon
authors.forename: D
authors.initials: D
authors.lastname: Miller
authors.forename: J R
authors.initials: JR
authors.lastname: Clark
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D003131:Combined Modality Therapy / Q000009:adverse effects; D003731:Dental Caries / Q000209:etiology; D005260:Female; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D006801:Humans; D007571:Jaw Diseases / Q000209:etiology; D008297:Male; D009059:Mouth Diseases / Q000209:etiology*; D010025:Osteoradionecrosis / Q000209:etiology; D011877:Radionuclide Imaging; D013280:Stomatitis / Q000209:etiology