title: Role of heterochromatin during preferential 9q;22q translocation in chronic myelogenous leukemia.
abstract: The secondary constriction region (h) of human chromosome 9 was evaluated in 55 chronic myelogenous leukemia (CML) patients with respect to its size and position. Each case was examined by C-banding and distamycin A-4,6-diamidino-2-phenylindole techniques for the expression of the h regions. When one h region of chromosome 9 was larger, it was more frequently involved in the reciprocal translocation with chromosome 22. In addition, there was a higher incidence of pericentric inversions in the h regions in the translocated chromosome 9 when compared with normal homologues. The role of the constitutive heterochromatin of chromosome 9 as a possible influencing factor during 9q;22q translocation in CML is suggested.
authors.forename: R S
authors.initials: RS
authors.lastname: Verma
authors.forename: J
authors.initials: J
authors.lastname: Rodriguez
authors.forename: A
authors.initials: A
authors.lastname: Babu
authors.forename: S
authors.initials: S
authors.lastname: Chemitiganti
authors.forename: M
authors.initials: M
authors.lastname: Coleman
authors.forename: R T
authors.initials: RT
authors.lastname: Silver
authors.forename: H
authors.initials: H
authors.lastname: Dosik
mesh_terms: D002871:Chromosome Banding; D002899:Chromosomes, Human, Pair 9; D006570:Heterochromatin / Q000502:physiology*; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D006570:Heterochromatin