title: Calmodulin in lymphocyte mitogenic stimulation and in lymphoid cell line growth.
abstract: Calmodulin levels are elevated three- to fourfold in the dividing cells, resulting from the lectin-induced stimulation of fresh human lymphocytes. This increase in calmodulin appears to be related mainly to progression into S phase and supports the hypothesis that calmodulin might be crucial in regulating the progression of lymphoblasts through their division cycle. Calmodulin levels are higher in a lymphoid cell line derived from human acute lymphoblastic leukemia blood cells than in a lymphoid cell line derived from normal human blood cells, suggesting that calmodulin could be an important mediator of the leukemogenetic process.
authors.forename: D
authors.initials: D
authors.lastname: Rainteau
authors.forename: A
authors.initials: A
authors.lastname: Sharif
authors.forename: R
authors.initials: R
authors.lastname: Bourrillon
authors.forename: S
authors.initials: S
authors.lastname: Weinman
mesh_terms: D002147:Calmodulin / Q000097:blood*; D002455:Cell Division; D002460:Cell Line; D002478:Cells, Cultured; D004261:DNA Replication; D005434:Flow Cytometry; D006801:Humans; D007399:Interphase; D007700:Kinetics; D007945:Leukemia, Lymphoid; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*
chemical_list: D002147:Calmodulin