[Experimental evaluation of the role of blood flow inhibition in hyperglycemia-enhanced radiation damage to tumors].
The authors provided experimental assessment of the role of the blood flow inhibition in enhancement of radiation injury to tumors using short-term hyperglycemia. Experiments on mice with Ehrlich solid carcinoma showed the dependence of a rise of the antitumor effect of preceding radiation induced by glucose and glucose combined with mexamine on a degree of the blood flow inhibition under the influence of these modifying agents. It was established that a considerable enhancement of radiation injury occurred but in such tumors where short-term hyperglycemia and mexamine decreased the blood flow level not less than 5-10 fold as estimated by 133Xe clearance. The results of the above experiments showed that noticeable inhibition of the blood flow in tumors was a necessary though, probably, not the only condition for a high efficacy of short-term hyperglycemia used as an adjuvant to radiotherapy.
Kozin
S V
SV
Sevast'ianov
A I
AI
Iarmonenko
S P
SP
D008735:5-Methoxytryptamine / Q000627:therapeutic use; D000818:Animals; D001786:Blood Glucose / Q000502:physiology*; D002286:Carcinoma, Ehrlich Tumor / Q000098:blood supply / Q000188:drug therapy / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D008297:Male; D051379:Mice
D001786:Blood Glucose; D008735:5-Methoxytryptamine
Eksperimental'naia otsenka roli ingibirovaniia krovotoka v usilenii giperglikemieĭ luchevogo porazheniia opukholeĭ.