Comparison of flupirtine and indomethacin on frusemide-induced diuresis.
A single oral dose of flupirtine maleate, a novel analgesic agent, did not antagonize significantly the diuretic action of frusemide when compared with indomethacin and placebo in normal human volunteers.
Johnston
A
A
Department of Clinical Pharmacology, St Bartholomew's Hospital, London, UK.
Warrington
S J
SJ
Turner
P
P
Riethmuller-Winzen
H
H
D000328:Adult; D000631:Aminopyridines / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D005665:Furosemide / Q000037:antagonists & inhibitors*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011897:Random Allocation
D000631:Aminopyridines; D000700:Analgesics; D005665:Furosemide; C034161:flupirtine; D007213:Indomethacin