Mutual additivity of hormonal and non-hormonal stimulation of gluconeogenesis.
Possible mutual additivity of the stimulating effects of fatty acids and alpha-adrenergic agents on gluconeogenesis was examined using isolated rat liver cells. Adrenaline or noradrenaline alone stimulated gluconeogenesis from lactate by 34% both in the absence and presence of propranolol. Oleate or acetate alone stimulated gluconeogenesis by 76% and 45%, respectively; propranolol did not influence the effects. Simultaneous administration of alpha-adrenergic agents with oleate or acetate increased gluconeogenesis by 110% and 90-100%, respectively, thus documenting mutual additivity of hormonal and non-hormonal stimulation; propranolol did not affect the mutual additivity of the effects observed.
Kümmel
L
L
Charles University, Faculty of Medicine, Prague, Czechoslovakia.
D000085:Acetates / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D004837:Epinephrine / Q000494:pharmacology*; D005227:Fatty Acids / Q000494:pharmacology*; D005943:Gluconeogenesis / Q000187:drug effects*; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D019301:Oleic Acid; D009829:Oleic Acids / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D000085:Acetates; D005227:Fatty Acids; D007773:Lactates; D009829:Oleic Acids; D019301:Oleic Acid; D011433:Propranolol; D009638:Norepinephrine; D004837:Epinephrine