The effect of piperazine adipate and parbendazole on the carbohydrate metabolism of Ascaridia galli and Heterakis gallinae.
Carbohydrate metabolism of Ascardia galli and Heterakis gallinae was studied after their exposure in vitro to 10(-2) to 10(-5) M piperazine adipate and parbendazole for 10 to 60 min. Following treatment with 10(-2) M piperazine adipate O2 uptake was reduced by 87% in A. galli and 70% in H. gallinae, while parbendazole (10(-2) M) reduced O2 uptake by 70% and 86%, respectively. Glycogen contents were reduced significantly by 10(-2) M piperazine adipate in both the worms, while lactic acid level was enhanced. Parbendazole, however, did not cause any significant change in glycogen contents and lactic acid level in either parasite.
Sharma
R K
RK
Postgraduate Department of Zoology, Bareilly College, India.
Singh
K
K
Saxena
K K
KK
D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D001197:Ascaridia / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D001562:Benzimidazoles / Q000494:pharmacology; D050260:Carbohydrate Metabolism; D006003:Glycogen / Q000032:analysis; D007773:Lactates / Q000032:analysis; D019344:Lactic Acid; D009348:Nematoda / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology
D000969:Antinematodal Agents; D001562:Benzimidazoles; D007773:Lactates; D010879:Piperazines; D019344:Lactic Acid; D006003:Glycogen; C100292:parbendazole; C005452:piperazine adipate