A convenient synthesis of 3 beta,12 alpha-, 3 beta,7 alpha-, and 3 beta,7 beta-dihydroxy-5-cholen-24-oic acids: unusual bile acids in human biological fluids.
The unusual bile acids 3 beta,12 alpha- (V), 3 beta,7 alpha- (XIIIa), and 3 beta,7 beta- (XIIIb) dihydroxy-5-cholen-24-oic acids were synthesized conveniently from the 3-oxo derivatives of deoxycholic (I) and lithocholic (VI) acids, respectively, to provide authentic samples for the gas chromatography-mass spectrometric determination of these bile acids in the abnormal metabolism of bile acids.
Tohma
M
M
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Hokkaido, Japan.
Mahara
R
R
Takeshita
H
H
Kurosawa
T
T
D001647:Bile Acids and Salts / Q000032:analysis*; D001826:Body Fluids / Q000032:analysis*; D002635:Chenodeoxycholic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D002793:Cholic Acids / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy
D001647:Bile Acids and Salts; D002793:Cholic Acids; D002635:Chenodeoxycholic Acid; C002287:3,7-dihydroxychol-5-enoic acid; C053140:3,12-dihydroxy-5-cholenoic acid