title: Macrophages in the central nervous system of the rat.
abstract: In an immunohistochemical study using monoclonal antibodies, which exclusively recognize cells of the monocyte-macrophage lineage, and monoclonal antibodies against the Ia-antigen, we describe the occurrence of macrophages in the developing and adult central nervous system (CNS). In normal adult brain, no macrophages could be detected in the CNS parenchyma; only in the meninges and the choroid plexes were a few macrophages found. During ontogeny, numerous phagocytic cells infiltrated the CNS parenchyma; these cells which did not express Ia are blood-borne. About three weeks after birth, all macrophages had disappeared from the CNS. As microglia in adult and developing brain do not stain with the anti-macrophage antibodies, we suggest that microglial cells are not related to the mononuclear phagocyte system and do not have a hematogenous origin.
authors.forename: T
authors.initials: T
authors.lastname: Sminia
authors.forename: C J
authors.initials: CJ
authors.lastname: de Groot
authors.forename: C D
authors.initials: CD
authors.lastname: Dijkstra
authors.forename: J C
authors.initials: JC
authors.lastname: Koetsier
authors.forename: C H
authors.initials: CH
authors.lastname: Polman
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002531:Cerebellum / Q000166:cytology* / Q000254:growth & development; D002540:Cerebral Cortex / Q000166:cytology* / Q000254:growth & development; D002831:Choroid Plexus / Q000166:cytology* / Q000254:growth & development; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007958:Leukocyte Count; D008264:Macrophages / Q000166:cytology* / Q000276:immunology; D008578:Meninges / Q000166:cytology* / Q000254:growth & development; D009457:Neuroglia / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains / Q000254:growth & development
chemical_list: D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II