title: Failure to relate mononuclear phagocyte system function to HLA-A, B, C, DR, DQ antigens in membranous nephropathy.
abstract: Nineteen patients with idiopathic membranous nephropathy were typed for HLA pattern and analyzed for the Fc receptor function of splenic macrophages by detecting in vivo the clearance of IgG-sensitized 51Cr-labelled autologous erythrocytes. Seven out of 19 patients were found to have a macrophage dysfunction. This defect was not related to any HLA-A, B, C, DR, DQ antigen tested nor to the levels of IgG-containing immune complexes, as detected by a Clq solid phase test, nor to the magnitude of proteinuria. Since HLA-B8 and HLA-DR3 antigens were significantly more frequent in patients than in the control group, the factors that may impair the macrophage system in individuals predisposed to this nephropathy are discussed.
authors.forename: D
authors.initials: D
authors.lastname: Roccatello
authors.forename: R
authors.initials: R
authors.lastname: Coppo
authors.forename: A
authors.initials: A
authors.lastname: Amoroso
authors.forename: E S
authors.initials: ES
authors.lastname: Curtoni
authors.forename: G
authors.initials: G
authors.lastname: Martina
authors.forename: B
authors.initials: B
authors.lastname: Basolo
authors.forename: A
authors.initials: A
authors.lastname: Amore
authors.forename: C
authors.initials: C
authors.lastname: Rollino
authors.forename: G
authors.initials: G
authors.lastname: Picciotto
authors.forename: D
authors.initials: D
authors.lastname: Cordonnier
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006683:HLA-DQ Antigens / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010586:Phagocytes / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens