Roles of gamma-aminobutyric acid and serotonin in the arcuate nucleus in the control of prolactin and luteinizing hormone secretion.
The effects of implantation of gamma-aminobutyric acid (GABA) and serotonin (5-HT) into the arcuate nucleus (ARC) on serum luteinizing hormone (LH) and prolactin (PRL) were examined in the conscious ovariectomized rat. Following implantation of 5-HT, but not GABA, serum PRL was significantly increased. While 5-HT did not affect pulsatile LH secretion, GABA significantly decreased the mean LH concentration and pulse frequency, but not amplitude.
Nishihara
M
M
Department of Physiology, Yokohama City University School of Medicine, Japan.
Kimura
F
F
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects*; D004343:Drug Implants; D005260:Female; D007986:Luteinizing Hormone / Q000097:blood*; D010052:Ovariectomy; D011388:Prolactin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D004343:Drug Implants; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D011388:Prolactin; D007986:Luteinizing Hormone