title: In vitro clonality of carcinomas as a prognostic parameter for the survival time of patients.
abstract: Clonal growth of tumour cell explants of squamous cell carcinomas of the jaw and face area can be induced in vitro. According to the clonality of tumours, the following 2 patient groups can be clearly distinguished: Patients with carcinomas whose in vitro growth involves a small number of clones (less than 45/1 X 10(5) cells disseminated). Patients with carcinomas whose in vitro growth involves a large number of clones (more than 45/1 X 10(5) cells disseminated). Demonstrating the same prognostic factors, these two patient groups have a significantly different life expectancy (p = 0.0001) 24 months following establishment of the diagnosis and cloning: more than 70% of the patients with low-cloning carcinomas, and less than 30% of the patients with high-cloning carcinomas are still alive. In vitro clonality of tumours is thus a prognostically relevant indicator of the expected survival time of affected patients.
authors.forename: H R
authors.initials: HR
authors.lastname: Metelmann
authors.forename: S
authors.initials: S
authors.lastname: Schlesinger
authors.forename: U
authors.initials: U
authors.lastname: Frucht
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology; D002455:Cell Division; D002999:Clone Cells; D003114:Colony-Forming Units Assay; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality* / Q000473:pathology; D009361:Neoplasm Invasiveness; D010610:Pharyngeal Neoplasms / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D012306:Risk; D014410:Tumor Stem Cell Assay