Dissolution of calcium fluoride tablets in vitro and bioavailability in man.
The dissolution rate of CaF2 tablets in vitro and the degree of F absorption in vivo after tablet intake in man were investigated. 50% of total F was released in 0.1 N HCl after 45 min whereas virtually no release was seen in H2O or in 0.2 M PO4-buffer pH 6.8. In spite of the modest release of F in simulated gastric juice in vitro no F absorption as judged from the plasma fluoride concentration curve was seen within 6 h after intake of 4 mg F as CaF2 tablets.
Afseth
J
J
Ekstrand
J
J
Hagelid
P
P
D000328:Adult; D001682:Biological Availability; D002124:Calcium Fluoride / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D005750:Gastric Juice / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D012995:Solubility; D013607:Tablets
D013607:Tablets; D002124:Calcium Fluoride