Suppression of delayed-type hypersensitivity to radiation [UV, 280-320 nm (UVB)]-induced tumor cells with serum factors from UVB-irradiated mice.
Irradiation--UV, 280-320 nm (UVB)--of the shaved dorsal skin of mice induces a systemic immunosuppression that interferes with the normal rejection of highly antigenic UVB radiation-induced skin cancers. Sera from C3H/HeNCr- female mice, exposed either to a single dose of UVB radiation (8.6 X 10(4) J/m2) or who received a 5-second thermal injury, were evaluated for ability to induce suppression of delayed-type hypersensitivity (DTH) to a syngeneic UVB-induced fibrosarcoma cell line, UV-2240. Sera from both UVB-irradiated and thermally injured donors could suppress the DTH responses of recipients, but only sera from UVB-irradiated donors could induce suppressor spleen cells to UV-2240 in recipient mice. The molecular-weight range of the UVB-induced serum factors is between 1,000 and 10,000.
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D000818:Animals; D002056:Burns / Q000276:immunology; D005260:Female; D006023:Glycoproteins / Q000032:analysis / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007108:Immune Tolerance / Q000528:radiation effects*; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight; D009363:Neoplasm Proteins; D009381:Neoplasms, Radiation-Induced / Q000276:immunology*; D014466:Ultraviolet Rays
D006023:Glycoproteins; D009363:Neoplasm Proteins; C038588:serum immunosuppressive factor, human