Pharmacokinetics of metamizol metabolites.
When administered to humans, metamizol rapidly undergoes predominantly nonenzymatic biotransformation, yielding a vast number of active and later inactive metabolites. The biotransformational pathways and the clinical significance of the metabolites are discussed in the light of their individual pharmacokinetics.
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D000107:Acetylation; D000632:Aminopyrine / Q000031:analogs & derivatives*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004177:Dipyrone / Q000031:analogs & derivatives / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D011485:Protein Binding
D000632:Aminopyrine; D004177:Dipyrone