[Value of cellular immunity tests (lymphocyte transformation test and leukocyte migration test) in the detection of sensitivity to drugs].
We studied degranulation of human basophils (HBDT), lymphoblast transformation and leucocyte migration in 8 cases of patients who were sensitive to penicillin (type 1 hypersensitization of the Gell and Coombes classification). The HBDT was negative in 7 of the cases, whilst the lymphoblast transformation and leucocyte migration tests were positive in 6 cases and negative in 2. These latter tests are more efficient than HBDT in the detection of human sensitization to penicillin.
Harrabi
S
S
Laboratoire de Biologie P. Loiseau et J. Dehenry, Sens.
Loiseau
P
P
Dehenry
J
J
Harrabi
S
S
D002464:Cell Migration Inhibition; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology*; D008213:Lymphocyte Activation; D010406:Penicillins / Q000276:immunology*
D010406:Penicillins
L'intérêt des tests d'immunité cellulaire (TTL et TML) dans la détection des sensibilisations aux médicaments.