title: A synthetic peptide vaccine involving the product of the pre-S(2) region of hepatitis B virus DNA: protective efficacy in chimpanzees.
abstract: The S gene encoding the major surface polypeptide of hepatitis B virus is preceded by the region pre-S(2) with a capacity to code for 55 amino acid residues. In the product of region pre-S(2), the sequence of 19 amino acid residues (amino acids 14-32 from the N terminus) representing an area of high local hydrophilicity is shared by viral strains of subtypes adr, ayw, and ayr; residue 22, phenylalanine, is replaced by leucine in a strain of the other subtype, adw. A synthetic peptide vaccine involving these 19 amino acid residues, when given to two chimpanzees, raised antibodies that bound to viral particles and protected the animals from challenge with 10(6) chimpanzee infectious doses of hepatitis B virus.
authors.forename: Y
authors.initials: Y
authors.lastname: Itoh
authors.forename: E
authors.initials: E
authors.lastname: Takai
authors.forename: H
authors.initials: H
authors.lastname: Ohnuma
authors.forename: K
authors.initials: K
authors.lastname: Kitajima
authors.forename: F
authors.initials: F
authors.lastname: Tsuda
authors.forename: A
authors.initials: A
authors.lastname: Machida
authors.forename: S
authors.initials: S
authors.lastname: Mishiro
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Miyakawa
authors.forename: M
authors.initials: M
authors.lastname: Mayumi
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D005814:Genes, Viral; D006509:Hepatitis B / Q000517:prevention & control*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006515:Hepatitis B virus / Q000145:classification / Q000235:genetics / Q000276:immunology*; D009842:Oligopeptides / Q000276:immunology; D002679:Pan troglodytes; D013045:Species Specificity; D014614:Vaccines, Synthetic / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000941:Antigens; D006514:Hepatitis B Surface Antigens; D009842:Oligopeptides; D014614:Vaccines, Synthetic; D014764:Viral Proteins; D014765:Viral Vaccines