title: Complex chromosomal abnormalities in a patient with lymphoid blast crisis of chronic myelogenous leukemia.
abstract: A 46-year-old Chinese man underwent lymphoid blast crisis (Ia+, CALLA+, TdT+) after 5 years of chronic phase, Philadelphia-chromosome positive chronic myelogenous leukemia. Chromosome analysis revealed a hyperdiploid karyotype, including two Philadelphia chromosomes--55,XY,t(9;22) (q34;q11), +2, +5, +5, +6, +10, +18, +19, +21, +del(22)(qll----qter)--in the majority of the leukemic blasts. The constellation of a lymphoid blast crisis and complex chromosomal abnormalities usually associated with myeloid blast crisis as well as the clinical data are discussed.
authors.forename: A
authors.initials: A
authors.lastname: Haubenstock
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.forename: R
authors.initials: R
authors.lastname: Zalusky
authors.forename: S C
authors.initials: SC
authors.lastname: Malamud
authors.forename: M H
authors.initials: MH
authors.lastname: Mernick
mesh_terms: D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000473:pathology*; D007951:Leukemia, Myeloid / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011003:Ploidies