Effect of hydrazide cysteine on the humoral immune response of mice to sheep erythrocytes.
Hydrazide of cysteine, introduced intraperitoneally or per os in three doses for three consecutive days after immunization of mice with SRBC, caused a stimulation or an inhibition of the humoral immune response, determined on day 4 as a number of cells in the spleen producing antibodies of 19S and 7S class. The stimulation of the humoral immune response was induced by the dose of 100 micrograms per mouse and was more significant in the case of the 7S response. High doses of HD, on the other hand (1 mg per mouse i.p. and 1-5 mg per mouse per os) caused an inhibition of the humoral immune response which was more pronounced in the case of the secondary immune response. The mechanism of action of HD in the course of the immune response and its possible application in therapy is discussed.
Wieczorek
Z
Z
Department of Experimental Therapy, Polish Academy of Sciences, Wrocław.
Spiegel
K
K
Ryzewski
J
J
Zimecki
M
M
D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003545:Cysteine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007274:Injections, Intraperitoneal; D051379:Mice; D008808:Mice, Inbred CBA; D012756:Sheep
C025196:cysteine hydrazide; D003545:Cysteine