The effect of etretinate, a synthetic retinoid, on pancreatic prostaglandin production.
Prostaglandin E2 levels in hamster pancreas were measured by radioimmunoassay. Control animals (N = 22) were compared to etretinate treated animals (N = 33). There was a highly significant reduction in pancreatic prostaglandin E2 production in the treated animals (means 1.842 ng/mg pancreas and 0.486, p less than 0.0005) suggesting that etretinate is a blocker of pancreatic prostaglandin production.
Skeggs
G B
GB
Murray
W R
WR
D000818:Animals; D006224:Cricetinae; D015232:Dinoprostone; D005050:Etretinate / Q000494:pharmacology*; D008647:Mesocricetus; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D011458:Prostaglandins E / Q000096:biosynthesis*
D011458:Prostaglandins E; D005050:Etretinate; D015232:Dinoprostone