title: The bioavailability and pharmacodynamics of chlormethiazole in healthy young and elderly volunteers: preliminary findings.
abstract: A preliminary analysis of a study of the bioavailability and pharmacodynamics of chlormethiazole in healthy young and elderly volunteers has been performed. The bioavailability assessed by a stable isotope method and the pharmacodynamic effects assessed by psychometric tests were found not to differ between the two age groups.
authors.forename: K G
authors.initials: KG
authors.lastname: Jostell
authors.forename: D
authors.initials: D
authors.lastname: Fagan
authors.forename: M
authors.initials: M
authors.lastname: Björk
authors.forename: F
authors.initials: F
authors.lastname: Broberg
authors.forename: R M
authors.initials: RM
authors.lastname: Mitchell
authors.forename: D B
authors.initials: DB
authors.lastname: Scott
authors.forename: B
authors.initials: B
authors.lastname: Ulff
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001143:Arousal / Q000187:drug effects; D001288:Attention / Q000187:drug effects; D001682:Biological Availability; D002719:Chlormethiazole / Q000097:blood* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011597:Psychomotor Performance / Q000187:drug effects
chemical_list: D002719:Chlormethiazole