Twin studies on urinary pepsinogen A phenotypes and serum pepsinogen A levels.
Urinary pepsinogen A (PGA or PG I) phenotypes and serum PGA levels were studied in MZ and DZ twins and their parents. In 45 out of 48 MZ twin pairs PGA patterns were completely identical, while 3 MZ twin pairs showed minor differences in the relative intensity of the Pg5 isozymogen. This suggests that the intensity of this isozymogen may be influenced by nongenetic factors. There was little difference in the interclass correlations of serum PGA levels between MZ and DZ twins, indicating a large contribution of common environmental factors to serum PGA levels. This is in contrast with previous studies.
Pronk
J C
JC
Institute of Human Genetics, Free University, Amsterdam; The Netherlands.
Boomsma
D I
DI
Pals
G
G
Frants
R R
RR
Overbeke
M
M
Meuwissen
S G
SG
Orlebeke
J F
JF
Eriksson
A W
AW
D000293:Adolescent; D004586:Electrophoresis; D004777:Environment; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D020116:Pepsinogen A; D010435:Pepsinogens / Q000097:blood* / Q000235:genetics*; D010641:Phenotype; D014427:Twins; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D010435:Pepsinogens; D020116:Pepsinogen A