title: Clinical improvement of two patients with T lymphotropic retrovirus diseases after polio vaccine hyperimmunization.
abstract: Patients with acute leukemia have an impaired ability to produce antibodies to poliovirus in response to inoculation with inactivated vaccine. Reimmunization will, however, produce a relative increase in antibodies equivalent to that of healthy subjects. A child with acute lymphocytic leukemia was hyperimmunized with Salk polio vaccine following a relapse and has had no further relapse nor sequelae for 20 years. An adult physician with acquired immunodeficiency syndrome hyperimmunized himself with the same vaccine, and the preliminary results are encouraging. The clinical improvement seen in these two patients following hyperimmunization with killed polio vaccine may reflect a secondary immune amplification that has been observed in humans following live polio virus immunization.
authors.forename: F N
authors.initials: FN
authors.lastname: Pitts
authors.forename: A D
authors.initials: AD
authors.lastname: Allen
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000628:therapy*; D000276:Adjuvants, Immunologic; D002648:Child; D006801:Humans; D007167:Immunotherapy; D007945:Leukemia, Lymphoid / Q000628:therapy*; D011054:Poliovirus Vaccine, Inactivated / Q000627:therapeutic use*
chemical_list: D000276:Adjuvants, Immunologic; D011054:Poliovirus Vaccine, Inactivated