Immediate and delayed effects of cis-platinum treatment on the short term biodistribution of 67Ga-citrate in mice.
The co-administration of a single medium toxic dose (5 mg/kg) of the chemotherapeutic drug cis-platinum (cis-Pt) with 67Ga-citrate was found to have minimal effects on the 3 h tissue distribution of the radiopharmaceutical in mice. When the same drug dose was given at two day intervals preceding the co-administered dose, virtually all tissues accumulated 67Ga to a greater extent. The tissue distribution of radiolabeled cis-Pt supported the development of drug-induced renal dysfunction as the primary cause.
Sykes
T R
TR
Noujaim
A A
AA
Stephens-Newsham
L G
LG
Lentle
B C
BC
Turner
A R
AR
D000818:Animals; D002945:Cisplatin / Q000378:metabolism / Q000494:pharmacology*; D005710:Gallium Radioisotopes / Q000378:metabolism*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013997:Time Factors; D014018:Tissue Distribution
D005710:Gallium Radioisotopes; D002945:Cisplatin