title: Optimal pressure waveforms for pressure-limited ventilation.
abstract: In this paper, we find the pressure waveform that minimizes the work of distending the alveoli in the lungs while achieving the desired mean airway pressure and alveolar tidal volume. The model used takes into account the compliance of the airway. The main result is a formula for the pressure waveform at the mouth as a function of time and lung parameters.
authors.affiliation: Department of Mathematics, Concordia University, Montreal, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Boyarsky
authors.forename: J
authors.initials: J
authors.lastname: Senez
mesh_terms: D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D011312:Pressure; D011650:Pulmonary Alveoli / Q000502:physiology*; D012119:Respiration