title: Distribution and metabolism of hexadecylphosphocholine in mice.
abstract: Distribution and metabolic fate of radiolabeled hexadecylphosphocholine (He-PC) has been studied in mice. It is demonstrated that He-PC is well-absorbed from the intestinal tract, intravenous (IV) and oral administration lead to similar distributions throughout the body, the highest accumulation of radioactivity occurs in liver, lung and kidney, and the metabolic products are radioactive choline, phosphocholine and 1,2-diacylphosphatidylcholine. The occurrence of these metabolites indicates that phospholipases C and D may be involved in He-PC breakdown.
authors.affiliation: Department of Internal Medicine, University Göttingen, Federal Republic of Germany.
authors.forename: A
authors.initials: A
authors.lastname: Breiser
authors.forename: D J
authors.initials: DJ
authors.lastname: Kim
authors.forename: E A
authors.initials: EA
authors.lastname: Fleer
authors.forename: W
authors.initials: W
authors.lastname: Damenz
authors.forename: A
authors.initials: A
authors.lastname: Drube
authors.forename: M
authors.initials: M
authors.lastname: Berger
authors.forename: G A
authors.initials: GA
authors.lastname: Nagel
authors.forename: H
authors.initials: H
authors.lastname: Eibl
authors.forename: C
authors.initials: C
authors.lastname: Unger
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002794:Choline / Q000031:analogs & derivatives*; D005260:Female; D051379:Mice; D010767:Phosphorylcholine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D010767:Phosphorylcholine; C039128:miltefosine; D002794:Choline