A naturally occurring deletion in the mouse Hbbs beta-globin gene cluster.
A restriction fragment size difference of 1.9 kilobases exists between the C57BL/10 (Hbbs) and BALB/c (Hbbd) beta-globin gene clusters in the vicinity of the Hbb-y and Hbb-bh0 genes. This length difference is the result of a deletion that removes the majority of the C57BL/10 Hbb-bh0 gene. The Hbb-bh0 deletion appears to be widespread among Hbbs-carrying mice. In addition to the deletion, 119 base pairs of DNA of unknown origin are found in C57BL/10 DNA at the point of discontinuity. The existence of this deletion is inconsistent with reports of transcripts homologous to the third exon of the Hbb-bh0 gene in both C57BL/10 embryos and in a cell line carrying the Hbbs haplotype. We propose that the Hbb-bh0 gene is a recently disabled pseudogene.
Holdener-Kenny
B
B
Weaver
S
S
D000818:Animals; D001483:Base Sequence; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D005838:Genotype; D005914:Globins / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D014158:Transcription, Genetic
D005914:Globins