Heritable fragile sites and cancer: fra(16)(q22) in lymphocytes of an acute nonlymphocytic leukemia patient with inv(16)(p13q22).
Fragile site testing was performed on normal peripheral blood lymphocytes from three acute nonlymphocytic leukemia patients who carried inv(16)(p13q22) in malignant cells. Cultures were treated with BrdU, distamycin A, Hoechst 33258, or folic acid deprivation to induce fragile site expression. One patient was found to be a carrier of fra(16)(q22), but the expression was observed only by Hoechst 33258 treatment.
Murata
M
M
Takahashi
E
E
Ishihara
T
T
Minamihisamatsu
M
M
Takagi
T
T
Kaneko
Y
Y
Hori
T
T
D000208:Acute Disease; D000328:Adult; D002648:Child; D002871:Chromosome Banding; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male
D005819:Genetic Markers