title: P300 and CT scan in patients with chronic schizophrenia.
abstract: Twenty chronic male schizophrenic subjects aged 30-50 years were examined by an auditory event-related potential procedure for the evaluation of the P300 component, a CT scan and a neuropsychological test battery. The P300 latency was increased and its amplitude was reduced. CT scan measures showed lateral and third ventricle enlargement, and there was a global neuropsychological impairment. Poor neuropsychological performances were consistently associated with delayed P300 latencies, but not with CT scan measures. Ventricular enlargement was more pronounced among subjects with a negative family history for major psychiatric disorders.
authors.affiliation: C. Mondino Institute, Neurological Clinic, Pavia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Romani
authors.forename: S
authors.initials: S
authors.lastname: Merello
authors.forename: L
authors.initials: L
authors.lastname: Gozzoli
authors.forename: F
authors.initials: F
authors.lastname: Zerbi
authors.forename: M
authors.initials: M
authors.lastname: Grassi
authors.forename: V
authors.initials: V
authors.lastname: Cosi
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D005072:Evoked Potentials, Auditory; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D014057:Tomography, X-Ray Computed