title: Hepatic metabolism of imipramine after prolonged administration of the drug to rats. An in vivo study.
abstract: The effect of prolonged administration of imipramine (IMI) to rats on the biliary excretion of IMI and its metabolites desipramine (DMI), 2-OH-imipramine (2-OH-IMI) and 2-OH-desipramine (2-OH-DMI) has been investigated. It was found that chronic IMI decreased the ratio DMI/IMI and 2-OH-IMI/IMI excreted with the bile and increased the ratio 2-OH-DMI/DMI. This was observed for 3 h after the last dose of chronic IMI, and suggested an inhibition of IMI demethylation and hydroxylation, and acceleration of DMI hydroxylation. 6 h after the dose of IMI the biliary ratio DMI/IMI and 2-OH-IMI/IMI increased and this might indicate an acceleration of IMI metabolism at later time intervals after IMI administration.
authors.affiliation: Institute of Pharmacology, Polish Academy of Sciences, Kraków.
authors.forename: M
authors.initials: M
authors.lastname: Melzacka
authors.forename: L
authors.initials: L
authors.lastname: Danek
authors.forename: A
authors.initials: A
authors.lastname: Adamus
mesh_terms: D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D001711:Biotransformation; D003891:Desipramine / Q000378:metabolism; D007099:Imipramine / Q000031:analogs & derivatives / Q000378:metabolism / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: C033803:2-hydroxyimipramine; D007099:Imipramine; D003891:Desipramine