title: Localizational concepts in epilepsy: past, present and future.
abstract: The clinical seizure pattern, particularly the initial phenomena, plus the EEG, when satisfactory recording of the seizure onset can be achieved, determine the primary localization of epileptic phenomena. The EEG has also demonstrated, by the presence of interictal epileptiform spike discharges, the presence of a second-order localization of epileptic phenomena, namely, the location and extent of cortex adjacent to the site of origin of the neuronal seizure discharge that is recruited into action in a clinical epileptic seizure. Experience with cortical resection in the treatment of focal epilepsy has demonstrated the importance of a third-order localization of epileptic phenomena, namely, how much of the potentially epileptogenic cortex must be excised in order to produce a satisfactory reduction of the seizure tendency.
authors.affiliation: Montreal Neurological Institute and Hospital, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Rasmussen
mesh_terms: D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology* / Q000601:surgery; D006801:Humans