Effects of dietary selenium and vitamin E on plasma lipoprotein cholesterol levels in male rats.
Male Fischer-344 rats fed a diet deficient in both vitamin E and selenium (Se) for 20 weeks had higher levels of low-density lipoprotein cholesterol than age-matched rats fed an identical diet but supplemented with these micronutrients. The rats supplemented with both vitamin E and Se were switched to a diet deficient in both these micronutrients at week 20. These rats eventually developed elevated levels of low-density lipoprotein cholesterol compared to age-matched rats either continuously maintained on the diet supplemented with vitamin E and Se or rats switched (at week 20) from the vitamin E-and Se-deficient diet to a diet supplemented with both these micronutrients. In a second experiment, we found that Se deficiency alone was sufficient to significantly elevate low-density lipoprotein cholesterol. The basal diet used in these experiments had a very low cholesterol content and the observed alterations in lipoprotein cholesterol levels are likely to reflect alterations in the metabolism of endogenously synthesized cholesterol.
Stone
W L
WL
Stewart
M E
ME
Nicholas
C
C
Pavuluri
S
S
D000818:Animals; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D015243:Cholesterol, VLDL; D004041:Dietary Fats / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012643:Selenium / Q000172:deficiency / Q000502:physiology*; D014810:Vitamin E / Q000502:physiology*; D014811:Vitamin E Deficiency / Q000378:metabolism
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D008079:Lipoproteins, VLDL; D014810:Vitamin E; D002784:Cholesterol; D005979:Glutathione Peroxidase; D012643:Selenium