Study of metabolism of psychotomimetic indolealkylamines by rat tissue extracts using liquid chromatography.
The use of a series of liquid chromatographic techniques involving cation-exchange, reverse-phase and normal-phase chromatography has permitted the separation and characterisation of a number of metabolites of the psychotomimetic indolealkylamines N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine which were isolated following incubation of these compounds with rat tissue extracts. In liver, kidney and brain tissue extracts the routes of metabolism identified included oxidative deamination, N-demethylation, O-demethylation and N-oxidation. The quantitative significance of individual routes of metabolism in these tissues was assessed using N,N-dimethyltryptamine as a substrate.
Sitaram
B R
BR
Talomsin
R
R
Blackman
G L
GL
McLeod
W R
WR
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003600:Cytosol / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008732:Methoxydimethyltryptamines / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism; D004130:N,N-Dimethyltryptamine / Q000031:analogs & derivatives / Q000378:metabolism*; D011594:Psychometrics; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000031:analogs & derivatives*; D014363:Tryptamines / Q000378:metabolism*
D008732:Methoxydimethyltryptamines; D014363:Tryptamines; D012701:Serotonin; D004130:N,N-Dimethyltryptamine