[Pharmacokinetics and clinical evaluation of cefotiam in pediatric surgery].
Pharmacokinetics and clinical studies on cefotiam (CTM) in pediatric surgery were performed and the results obtained are summarized below. In neonates without congenital heart disease (CHD), serum levels of CTM were rapidly increased following injection of CTM (20 mg/kg, one shot intravenous administration) and the peak values were found at 15 minutes. Six hours later, CTM almost disappeared from the blood. In the patient with CHD, however, CTM was retained in the serum and the urinary excretion was poor. The CTM was administrated prophylactically to prevent postoperative infections in 10 patients. Eight of 10 had no episodes during postoperative period. Wound infection, however, was found in 2 patients. No clinical and laboratory side effects were caused by CTM.
Yura
J
J
Tsuruga
N
N
Hashimoto
T
T
Kamiya
Y
Y
Hayashi
S
S
Murata
Y
Y
D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D015310:Cefotiam; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D011292:Premedication; D013514:Surgical Procedures, Operative; D013530:Surgical Wound Infection / Q000517:prevention & control*
D015310:Cefotiam; D002439:Cefotaxime