[Prostaglandin E2 gel for ripening the cervix and/or labor induction in the unripe cervix at the end of pregnancy].
Endocervical instillation of a Prostaglandin-E2-containing-gel is a well accepted method to ripen the cervix before induction or to induce labor directly. Until now the main problem of this method were difficulties with the preparation of the Prostaglandin-gel-mixture. In the present study a prefabricated 0.5 mg PGE2 containing gel was tested with relation to its safety and efficacy. During the period of one year no gel-specific difficulties e.g. stability, homogeneity or sterility occurred. 57% of the nulliparas and 71% of the multiparas with a modified Bishop-score of smaller or equal to 5 could be delivered within 12 hours of the first gel-application. In most of the remaining women no substantial cervical ripening could be detected. In only 12% of nulliparas and 6% of multiparas labor could not be induced by means of the second gel-application. The rate of operative deliveries in this group of low risk patients was low (4.1% in nulliparas and 1.9% in multiparas). The fetal outcome was excellent in all instances. Maternal side effects could be detected in 5 women. Based on our experience endocervical PGE2-gel-instillation can be considered a safe and very efficacious method of induction of labor in unfavorable cervical-score.
Egarter
C
C
Grünberger
W
W
Husslein
P
P
D002584:Cervix Uteri / Q000187:drug effects*; D015232:Dinoprostone; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D010298:Parity; D011247:Pregnancy; D011446:Prospective Studies; D011458:Prostaglandins E / Q000008:administration & dosage*; D014590:Uterine Contraction / Q000187:drug effects
D011458:Prostaglandins E; D015232:Dinoprostone
Prostaglandin-E2-Gel zur Reifung der Zervix und/oder zur Geburtseinleitung bei unreifer Portio am Ende der Schwangerschaft.