Localization of the human c-mos gene by in situ hybridization in two cases of acute nonlymphocytic leukemia type M2.
The t(8;21)(q22.1;q22.3) is specific for the FAB-M2 subtype of acute nonlymphocytic leukemia (ANLL). The human c-mos protooncogene is located near the site of rearrangement on chromosome #8, at a position corresponding to band 8q22. The present in situ hybridization studies were performed in order to establish if c-mos is transposed from chromosome #8 to chromosome #21, in two cases of M2-ANLL showing the typical t(8;21). A statistical analysis of the results revealed that the c-mos oncogene was definitely not translocated from chromosome #8 to #21 in one of these patients, and was inconclusive in the other patient. The findings in the former patient suggest that either c-mos is not involved in the etiology of M2-ANLL or, alternatively, if c-mos is important in the pathogenesis of this disease, it must be activated by some mechanism other than transposition of this oncogene to an aberrant position.
Rosendorff
J
J
Bowcock
A M
AM
Kuyl
J M
JM
Mendelow
B
B
Pinto
M R
MR
Bernstein
R
R
D000208:Acute Disease; D002871:Chromosome Banding; D002898:Chromosomes, Human, Pair 8; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008297:Male; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes; D014178:Translocation, Genetic
D005819:Genetic Markers