The pharmacokinetics of enoxacin in elderly patients.
Twenty-three patients of greater than 70 years of age, with proven urinary tract infections were treated with 200 mg of enoxacin twice daily. Serial blood samples were taken on day 1 and peak and trough levels on days 3 and 5. Enoxacin and oxo-enoxacin plasma levels were measured. The mean plasma half-lives of enoxacin and the oxo-metabolite were 6.1 h and 6.7 h respectively. The 2 h plasma level of enoxacin increased from a mean of 1.5 mg/l on day 1 to 2.65 mg/l on day 3 and 2.80 mg/l on day 5. No significant accumulation of the oxo-metabolite (as judged by the 2 h level) occurred. No alteration in enoxacin dosing in the elderly compared with that in younger patients is suggested. Eighty-five per cent of the patients were cured of their infection and no significant adverse advents were noted.
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D000368:Aged; D000369:Aged, 80 and over; D000892:Anti-Infective Agents, Urinary / Q000378:metabolism* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D015365:Enoxacin / Q000031:analogs & derivatives; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D009287:Naphthyridines / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000892:Anti-Infective Agents, Urinary; D009287:Naphthyridines; D015365:Enoxacin; C049814:4-oxo-enoxacin