Experimental use of prostaglandin E2 (Dinoprost) in the treatment of duodenal ulcer in humans.
Oral administration of 20 mg PGE2/day/patient (5 mg every 4 hours, 4 times a day) promptly relieved pain in 10 patients suffering from duodenal ulcer. After 3 days of treatment, the ulceration--observed by radiologic and gastrofibroscopic means--diminished by 30% in dimensions, and after 10 days, it almost disappeared. The results were compared with those observed in a placebo-group, who received 20 mg lactose/day/patient and with those in another group treated by sodium bicarbonate.
Popescu
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D000284:Administration, Oral; D000328:Adult; D015232:Dinoprostone; D004381:Duodenal Ulcer / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005336:Fiber Optic Technology; D005745:Gastric Acidity Determination; D006801:Humans; D007700:Kinetics; D008297:Male; D011458:Prostaglandins E / Q000008:administration & dosage / Q000627:therapeutic use*; D011859:Radiography; D013997:Time Factors
D011458:Prostaglandins E; D015232:Dinoprostone