Synthetic factor for evaluation of the effectiveness of the therapy in ovarian carcinoma.
The synthetic factor based on determinations of 10 parameters in sera of patients with ovarian carcinoma, was constructed. The factor was found to be useful in evaluation of the effectiveness of the cytotoxic treatment and in indication of the recurrence of the malignancy. Reduction of the number of biochemical markers to five (haptoglobin, seromucoid, lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase), according to significance of particular markers in the laboratory diagnostics of ovarian cancer did not affect the diagnostic sensitivity of the synthetic factor.
Dobryszycka
W
W
Department of Pharmaceutical Biochemistry, Medical Academy, Wroclaw.
Waszkiewicz
L
L
Kuriata
E
E
Peisert
E
E
Gerber
J
J
Ujec
M
M
D000469:Alkaline Phosphatase / Q000032:analysis; D001219:Aspartate Aminotransferases / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000032:analysis / Q000628:therapy*; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D009961:Orosomucoid / Q000032:analysis; D010051:Ovarian Neoplasms / Q000032:analysis / Q000628:therapy*; D011379:Prognosis; D013223:Statistics as Topic
D014408:Biomarkers, Tumor; D006242:Haptoglobins; D009961:Orosomucoid; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase