[Experimental study on the developmental mechanism of stress ulcer--especially on changes in PGE2].
A study was made on changes in the gastric mucosal prostaglandin (PGE2) at the time of onset of stress ulcer in view of the association between those changes and the blood flow of the gastric mucosa, and further study was performed on the preventive effect of pGE2 and carboxymethoxy-4,4'-bis (3-methyl-2-butenyloxy) chalcone (hereinafter referred to as SU-88) administered to the enthetic cases. When the control rats were loaded with water immersion stress, a noticeable decline of as much as about 50% was seen in the blood flow of gastric mucosa in 2 hours, and simultaneously a decrease was recognized in the quantity of the gastric mucosal pGE2 approximately 32%. On the other hand, these changes are controlled in the vagotomized rats. In comparison with vagotomized rats, a decline was seen in the gastric mucosal PGE2 while an increase was observed in it in the rats with the vagus nerves stimulated by bethanechol. In the dehemotized (24 ml/kg) rats and the rats loaded with water immersion stress, a decline was seen in the synthesis of the gastric mucosal pGE2. Administration of PGE2 and SU-88 before the loading of stress suppressed an increase in the quantity of the gastric mucosal pGE2 and the blood flow of the gastric mucosa.
Hayasi
T
T
Urakawa
T
T
Saitoh
Y
Y
D000818:Animals; D002599:Chalcone / Q000031:analogs & derivatives / Q000494:pharmacology; D047188:Chalcones; D015232:Dinoprostone; D005753:Gastric Mucosa / Q000032:analysis*; D007101:Immersion; D008297:Male; D010437:Peptic Ulcer / Q000209:etiology* / Q000503:physiopathology; D011458:Prostaglandins E / Q000032:analysis / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000098:blood supply; D013312:Stress, Physiological; D014628:Vagotomy
D047188:Chalcones; D011458:Prostaglandins E; C035032:sofalcone; D002599:Chalcone; D015232:Dinoprostone