The effects of a constant T3 level and thermoneutrality in diet-induced hyperphagia.
Rats were thyroidectomized, then fitted with a miniosmotic pump infusing T3, thereby assuring a constant circulating level of T3. After a ten-day recovery period, they were submitted either to a chow or to a cafeteria diet. Body weight, food intake, and energy expenditure were recorded during a thirty day period. Thyroidectomized T3 supplemented rats did not exhibit hyperphagia when fed a cafeteria diet. Despite this puzzling normophagia, they still chose nutrients in a distribution similar to that of other cafeteria-fed rats and, though maintaining the same weight as chow-fed rats, increased their proportion of fatty weight compared to these rats. The relationship between energy expenditure, T3 concentration, and cafeteria diet are discussed.
Abraham
G
G
Falcou
R
R
Rozen
R
R
Mandenoff
A
A
Autissier
N
N
Apfelbaum
M
M
D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D001835:Body Weight; D004032:Diet; D002149:Energy Intake; D004734:Energy Metabolism; D001068:Feeding and Eating Disorders / Q000378:metabolism*; D006963:Hyperphagia / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009929:Organ Size; D010101:Oxygen Consumption; D051381:Rats; D011919:Rats, Inbred Strains; D013696:Temperature; D013965:Thyroidectomy; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine