Tourette syndrome: successful treatment with clonidine and oxycodone.
A 15-year-old boy with Tourette's syndrome exhibited severe involuntary self-mutilatory behavior. While clonidine effectively controlled the motor and phonic tics, it failed to ameliorate the self-mutilatory behavior. Administration of oxycodone (50 mg/day) combined with clonidine produced a dramatic reduction in the frequency and severity of the self-mutilatory acts within 12 h. This report indicates that disturbances in the functional interplay between the noradrenergic and opiatergic systems may be important in the pathophysiology of Tourette's syndrome.
Sandyk
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D000293:Adolescent; D003000:Clonidine / Q000008:administration & dosage*; D003061:Codeine / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D010098:Oxycodone / Q000008:administration & dosage*; D005879:Tourette Syndrome / Q000188:drug therapy*
D010098:Oxycodone; D003000:Clonidine; D003061:Codeine