[Occurrence of IgE-dependent food allergy in asthmatic disease].
The incidence of food allergy has been evaluated in 67 asthmatic patients (allergic asthma: 52, intrinsic asthma: 15). History was positive for post-meals attacks (7), symptoms involving other target organs (61%). Prick tests were found positive in 17/60; intradermal 77/682. Out of 110 human basophil degranulation tests or RAST, performed in 44 patients, 21/15 patients were found positive. Out of 18 inhalation challenges, 7 were positive. Out of 17 food oral challenges, 6 were positive (8 patients). A definite diagnosis of food allergy was accepted for 9 patients. Elimination diet, with 600 mg/day of cromolyn, induced a major improvement in 7 patients within 3 months, with 2 further failures after 1 year. A successful elimination diet was correlated with a positive food challenge. The relative incidence of food allergy in asthmatic adults is discussed (5.8%), as well as a non-immunologic mediated intolerance to food additives in intrinsic asthmatics, the incidence of vegetable allergies in pollen-sensitive patients, the procedures and meaning of inhalation and oral challenges, the relative importance of trophallergens. Food allergy appears to be a variable co-factor in bronchial hyperreactivity.
Moneret-Vautrin
D A
DA
Mohr
N
N
Gérard
H
H
Nicolas
J P
JP
Lacoste
J
J
Grilliat
J P
JP
D001249:Asthma / Q000150:complications / Q000276:immunology*; D001985:Bronchial Provocation Tests; D005260:Female; D005512:Food Hypersensitivity / Q000178:diet therapy / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D012882:Skin Tests
D007073:Immunoglobulin E
Incidence de l'allergie alimentaire IgE-dépendante dans la maladie asthmatique.