title: Treatment of mineralocorticoid-resistant renal hyperkalemia with hypertension (type II pseudohypoaldosteronism).
abstract: A 16 year old girl with the rare syndrome characterised by hypertension, hyperkalemia, and acidosis was treated with a range of drugs, including thiazides, frusemide, and beta-adrenoceptor antagonists. None of the agents normalised the hypertension and biochemical abnormalities. Best results were obtained with methyclothiazide in full dosage, which normalised the blood pressure, serum potassium level, and bicarbonate level in the face of increased plasma renin activity. Empirical treatment with thiazides is the most satisfactory method for long term management.
authors.forename: V S
authors.initials: VS
authors.lastname: Wayne
authors.forename: J R
authors.initials: JR
authors.lastname: Stockigt
authors.forename: G L
authors.initials: GL
authors.lastname: Jennings
mesh_terms: D000138:Acidosis / Q000150:complications; D000293:Adolescent; D002712:Chlorides / Q000097:blood; D004351:Drug Resistance; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000150:complications / Q000188:drug therapy*; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008607:Intellectual Disability / Q000150:complications; D008736:Methyclothiazide / Q000627:therapeutic use; D008901:Mineralocorticoids / Q000627:therapeutic use; D013577:Syndrome
chemical_list: D002712:Chlorides; D008901:Mineralocorticoids; D008736:Methyclothiazide