Clonidine in the treatment of Tourette's syndrome exacerbation due to haloperidol withdrawal.
A patient with long-standing Tourette's syndrome had a dramatic exacerbation of symptoms following the rapid withdrawal of haloperidol. Clonidine administration resulted in a disappearance of tics, which recurred 6 days later. The role of clonidine in blocking withdrawal-induced symptoms in patients with Tourette's syndrome treated with long-term neuroleptics is discussed from a clinical and neurobiological perspective. The implications of this case for the treatment of supersensitivity psychosis and tricyclic withdrawal states with clonidine are also discussed.
Max
J E
JE
Rasmussen
S A
SA
D000208:Acute Disease; D000328:Adult; D003000:Clonidine / Q000627:therapeutic use*; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000209:etiology; D005879:Tourette Syndrome / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology
D006220:Haloperidol; D003000:Clonidine