Antidiuretic and cardiovascular actions of prostaglandin E2 in the rainbow trout Salmo gairdneri.
The renal and cardiovascular actions of intravenous injection or infusion of prostaglandin E2 (PGE2) have been investigated in the anaesthetised rainbow trout, Salmo gairdneri. Amounts of 1-2500 ng PGE2/kg body wt had a potent vasodilatory action and caused rapid dose-related decreases in dorsal aortic blood pressure. Intravenous infusion of PGE2 was associated with a secondary tachycardia and vasoconstriction. Injection of PGE2 resulted in transient dose-related decreases of urine production. Infusion of PGE2 at 200 ng/min/kg rapidly decreased glomerular filtration rates by reducing the populations of filtering nephrons and later by increasing the renal tubular water reabsorption. The possible endocrine systems which may be involved in the renal responses to PGE2 are discussed.
Brown
J A
JA
Bucknall
R M
RM
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D015232:Dinoprostone; D004231:Diuresis / Q000187:drug effects*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology*; D012487:Salmonidae / Q000502:physiology*; D014337:Trout / Q000502:physiology*
D011458:Prostaglandins E; D015232:Dinoprostone