title: Body weight and brown fat activity in hyperphagic cafeteria-fed female rats and their offspring.
abstract: Presenting pregnant rats with a varied choice of human food items (a cafeteria diet) caused a slight reduction in total protein intake and significant increases in energy intake (32%) and weight gain compared to pregnant females fed stock diet (controls). Cafeteria-fed mothers gave birth to the same number and weight of pups as controls, and these grew normally, but were fatter at weaning than control pups. Cafeteria-fed dams lost more weight than controls during lactation, in spite of sustained hyperphagia, and body fat and energy was the same as controls at 21 days post-partum. Brown adipose tissue protein content and thermogenic activity (assessed from mitochondrial purine nucleotide binding) were both elevated in cafeteria-fed mothers when compared to controls at 21 days post-partum, but brown fat activity in their offspring at weaning did not differ between treatments, although tissue protein content was depressed in the pups of cafeteria-fed dams.
authors.forename: N J
authors.initials: NJ
authors.lastname: Rothwell
authors.forename: M J
authors.initials: MJ
authors.lastname: Stock
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001835:Body Weight; D004734:Energy Metabolism; D005247:Feeding Behavior / Q000502:physiology; D001068:Feeding and Eating Disorders / Q000503:physiopathology*; D005260:Female; D006963:Hyperphagia / Q000378:metabolism / Q000503:physiopathology*; D007774:Lactation; D011247:Pregnancy; D011270:Pregnancy, Animal; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011506:Proteins