title: Association of adverse perinatal events with an empty sella turcica in children with growth hormone deficiency.
abstract: High-resolution computed tomography (HR-CT) of the hypothalamo-pituitary region was performed in 26 consecutive children presenting with growth hormone deficiency (GHD) at one clinic. 58% had an empty sella turcica (ES) and 42% a full sella turcica (FS). There was no difference between the ES and FS groups for mean (+/- 95% confidence limits) presentation age (ES 6.7 (+/- 1.8) years, FS 5.6 (+/- 2.2) years), height standard deviation score (SDS) (ES -3.9 (+/- 0.8), FS -3.3 (+/- 0.5] nor head circumference SDS (ES -1.9 (+/- 1.1), FS -0.7 (+/- 1.1]. There were significant associations between the ES group and a history of adverse perinatal events (p less than 0.001) and multiple pituitary deficiency (p = 0.014). Growth hormone response to an acute growth hormone releasing factor test showed no association with HR-CT diagnosis. Sella turcica volumes were calculated from the HR-CT scans. All sella volumes were small; mean SDS for height was -2.6 (+/- 0.2). There was no difference in sella volume SDS between the ES and FS groups (ES -2.9 (+/- 0.3), FS -2.5 (+/- 0.4]. Adverse perinatal events may cause an ES and GHD by compromising the blood supply to the pituitary gland or infundibulum.
authors.affiliation: Department of Child Health, University of Manchester School of Medicine, UK.
authors.forename: R
authors.initials: R
authors.lastname: Surtees
authors.forename: J
authors.initials: J
authors.lastname: Adams
authors.forename: D
authors.initials: D
authors.lastname: Price
authors.forename: P
authors.initials: P
authors.lastname: Clayton
authors.forename: S
authors.initials: S
authors.lastname: Shalet
mesh_terms: D001720:Birth Injuries / Q000150:complications*; D004652:Empty Sella Syndrome / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism; D005260:Female; D005315:Fetal Diseases / Q000150:complications; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D007031:Hypothalamus / Q000000981:diagnostic imaging; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000150:complications*; D007235:Infant, Premature, Diseases; D008297:Male; D010903:Pituitary Gland, Anterior / Q000000981:diagnostic imaging; D011247:Pregnancy; D012658:Sella Turcica / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D013006:Growth Hormone