title: Effect of chlormethiazole on the hepatic monooxygenase enzyme system.
abstract: Ethanol abuse has been shown to induce hepatic monooxygenase activity. In order to study the effect of chlormethiazole on the hepatic monooxygenase enzyme system, the O-deethylation of 7-ethoxycoumarin was studied. Chlormethiazole was found to inhibit ethanol-induced monooxygenase activity.
authors.forename: H P
authors.initials: HP
authors.lastname: Hoensch
mesh_terms: D000328:Adult; D002719:Chlormethiazole / Q000494:pharmacology*; D003374:Coumarins / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008108:Liver Diseases, Alcoholic / Q000201:enzymology; D008297:Male; D010105:Oxygenases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014468:Umbelliferones / Q000378:metabolism
chemical_list: D003374:Coumarins; D014468:Umbelliferones; D002719:Chlormethiazole; C017299:7-ethoxycoumarin; C031477:7-hydroxycoumarin; D010105:Oxygenases