Presence of isochromosomes in hematologic diseases.
Several different structural chromosome aberrations have been observed in human neoplasias. In this report we describe the isochromosomes found in nine patients with hematologic malignancies: five with leukemia, one with sideroblastic anemia, and three with malignant lymphomas. The isochromosomes i(7q), i(11q), i(17q), and i(21q) were detected in these patients. We suggest that the presence of isochromosomes permits us to speak of a gene-dosage effect and that this mechanism may play a role in malignant transformation.
Labal de Vinuesa
M
M
Slavutsky
I
I
Larripa
I
I
D000328:Adult; D000368:Aged; D002648:Child; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D002886:Chromosomes, Human, Pair 17; D002891:Chromosomes, Human, Pair 21; D002897:Chromosomes, Human, Pair 7; D005260:Female; D005819:Genetic Markers; D006402:Hematologic Diseases / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged
D005819:Genetic Markers