title: Microbial transformation of azacarbazoles. VIII. Production of 14C-labelled benzo-alpha-iso-carbolines by permeabilized cells of Kitasatosporia setae strain.
abstract: N-1 methylation of benzo-alpha-carbolines performed with Kitasatosporia setae strain yields corresponding benzo-alpha-iso-carbolines, compounds demonstrating relatively strong cytostatic and antitumor properties. To obtain radioactive benzo-alpha-iso-carbolines required for the further studies of their mode of antitumor action, a simple and useful method of the preparation of 14C-labelled compounds by microbial means has been elaborated.
authors.affiliation: Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
authors.forename: W
authors.initials: W
authors.lastname: Peczyńska-Czoch
mesh_terms: D000192:Actinomycetales / Q000378:metabolism*; D001711:Biotransformation; D002243:Carbolines / Q000493:pharmacokinetics*; D002463:Cell Membrane Permeability; D004121:Dimethyl Sulfoxide; D008745:Methylation
chemical_list: D002243:Carbolines; D004121:Dimethyl Sulfoxide