title: Methotrexate infusions in poor prognosis acute lymphoblastic leukemia in children: I. The Norwegian methotrexate study in acute lymphoblastic leukemia in childhood, August 1975-December 1980.
abstract: One hundred fifty-three children with ALL were diagnosed in Norway in the period August 1975-December 1980. One hundred thirty-two of them received 3 infusions of methotrexate as consolidation therapy combined with methotrexate intrathecally as CNS prophylaxis. Eleven (44%) of the total 25 methotrexate cases with WBC above 50 X 10(9)/L were in CCR after 4 1/2-10 years. Two more cases had discontinued therapy, while in second remission. The event-free survival of all diagnosed 32 children in Norway with WBC above 50 X 10(9)/L was 37%. Seven infants below the age of 1 year are included in the 32 cases.
authors.forename: P J
authors.initials: PJ
authors.lastname: Moe
authors.forename: M
authors.initials: M
authors.lastname: Seip
authors.forename: P H
authors.initials: PH
authors.lastname: Finne
authors.forename: S
authors.initials: S
authors.lastname: Kolmannskog
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007945:Leukemia, Lymphoid / Q000188:drug therapy* / Q000401:mortality; D008727:Methotrexate / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D008727:Methotrexate