Differential patterns of expression of cell cycle-related genes in blast cells of acute myeloid leukemia.
The expression of two G1-specific clones, p2A9 and p4F1, of two cell cycle-related oncogenes, c-myc and c-myb and of one S phase-specific gene, the H3 histone gene, was explored in 11 cases of acute myeloid leukemia. Both Northern blot analysis and in-situ hybridization were employed. Differential patterns of gene expression were observed. In 6 out of 11 cases a considerable or high expression of the p2A9 and p4F1 clones and of c-myc and c-myb oncogenes was observed. In 2 cases a high expression of c-myc was matched by low or absent expression of the other genes examined. In 3 cases the expression of 2A9, 4F1, c-myc and c-myb was very low or undetectable. In two of these cases a considerable expression of the H3 histone gene was observed.
Torelli
U
U
Selleri
L
L
Venturelli
D
D
Donelli
A
A
Emilia
G
G
Ceccherelli
G
G
Turchi
L
L
Torelli
G
G
D006657:Histones / Q000235:genetics; D006801:Humans; D007399:Interphase; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009857:Oncogenes
D006657:Histones