Pharmacokinetics of ofloxacin and theophylline alone and in combination.
The pharmacokinetic interactions of ofloxacin (2 X 200 mg) and theophylline (3 X 200 mg) were investigated in 12 healthy volunteers over a period of two weeks. In the first week, theophylline was given over five days to reach a steady state. In the second week, the combination of theophylline and ofloxacin was applied. Cmax, tmax, AUC0-8, the serum elimination constant and serum half-life of theophylline were not changed when theophylline was given alone or in combination with ofloxacin. The kinetic parameters of ofloxacin were in accordance with data from the literature.
Fourtillan
J B
JB
Granier
J
J
Saint-Salvi
B
B
Salmon
J
J
Surjus
A
A
Tremblay
D
D
Vincent Du Laurier
M
M
Beck
S
S
D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood*; D004347:Drug Interactions; D006801:Humans; D007700:Kinetics; D008297:Male; D015242:Ofloxacin; D010078:Oxazines / Q000008:administration & dosage / Q000097:blood*; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood*
D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin; D013806:Theophylline