title: Estrogens regulate production of specific growth factors in hormone-dependent human breast cancer.
abstract: Human breast cancer cells in long-term tissue culture are responsive to estrogens as assessed by activation of specific gene products. A group of estrogen-regulated, secreted growth factors are responsible for the proliferative responses of these cells both in vitro and in vivo.
authors.forename: M E
authors.initials: ME
authors.lastname: Lippman
authors.forename: S
authors.initials: S
authors.lastname: Bates
authors.forename: K K
authors.initials: KK
authors.lastname: Huff
authors.forename: N
authors.initials: N
authors.lastname: Davidson
authors.forename: R B
authors.initials: RB
authors.lastname: Dickson
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002460:Cell Line; D003470:Culture Media; D066246:ErbB Receptors / Q000032:analysis; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006133:Growth Substances / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis; D007532:Isoleucine / Q000494:pharmacology; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism* / Q000473:pathology; D010452:Peptide Biosynthesis; D015291:Transforming Growth Factors
chemical_list: D000911:Antibodies, Monoclonal; D003470:Culture Media; D004967:Estrogens; D006133:Growth Substances; D007532:Isoleucine; D007334:Insulin-Like Growth Factor I; D015291:Transforming Growth Factors; D066246:ErbB Receptors