Oral immunization and protection of raccoons (Procyon lotor) with a vaccinia-rabies glycoprotein recombinant virus vaccine.
Animal rabies control has been frustrated by the existence of multiple wildlife reservoirs and the lack of efficacious oral vaccines. In this investigation, raccoons fed a vaccinia-rabies glycoprotein recombinant virus in a sponge bait developed rabies virus-neutralizing antibody (0.6-54.0 units) and resisted street rabies virus infection 28 and 205 days after feeding. Additional raccoons immunized by oral infusion with attenuated antigenic variants of rabies virus strains CVS-11 and ERA failed to develop rabies virus-neutralizing antibody. This work demonstrates the feasibility of a recombinant virus vaccine containing the rabies glycoprotein gene for immunization of raccoons, and possibly other wildlife, to obtain long-term protection against rabies.
Rupprecht
C E
CE
Wiktor
T J
TJ
Johnston
D H
DH
Hamir
A N
AN
Dietzschold
B
B
Wunner
W H
WH
Glickman
L T
LT
Koprowski
H
H
D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D004197:Disease Reservoirs; D006023:Glycoproteins / Q000276:immunology*; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000276:immunology*; D011821:Raccoons; D011994:Recombinant Proteins; D014611:Vaccination / Q000662:veterinary*; D014616:Vaccinia virus / Q000276:immunology*
D000914:Antibodies, Viral; D006023:Glycoproteins; D011819:Rabies Vaccines; D011994:Recombinant Proteins