title: The possibilities of the automated morphometry in the diagnosis of the hyperlipoproteidemia. Morphometry in the diagnosis of the hyperlipoproteidemias.
abstract: Following are the results of using the elaborated algorhythms of the structural analysis for the study of the form elements of the blood. A possibility was demonstrated to carry out a differential diagnosis of the familial hyperlipoproteidemia of the second type according to the quantitative structural parametres of the chromatin of the inter-phase nuclei of the lymphocytes of the peripheral blood. A method was developed of the automated morphometry of erythrocytes making it possible to assess the optical profile of erythrocytes according to 16 parametres. It was also registered a more vivid change of the curve of the membrane of the erythrocytes as compared with the Price-Jones spread on the same erythrocytes. With a help of a system of proposed parametres, which are 4-6-fold more informative and sensitive, than the traditional ones, it is possible to obtain the qualitatively new characteristics of the forms of erythrocytes, and not only their sizes.
authors.affiliation: Scientific Research Institute of Physico-Chemical Medicine, Ministry of Public Health of the Russian Federation, Moscow.
authors.forename: A V
authors.initials: AV
authors.lastname: Zhukotsky
authors.forename: N N
authors.initials: NN
authors.lastname: Butusova
authors.forename: K M
authors.initials: KM
authors.lastname: Umudov
authors.forename: E M
authors.initials: EM
authors.lastname: Kogan
mesh_terms: D002843:Chromatin / Q000648:ultrastructure; D003581:Cytodiagnosis / Q000379:methods*; D004912:Erythrocytes / Q000648:ultrastructure; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D007399:Interphase; D008214:Lymphocytes / Q000648:ultrastructure
chemical_list: D002843:Chromatin