Effect of selenium on developing mouse teeth in culture in vitro.
First molars from 2-day-old mice were cultured for 7 days in medium supplemented with 0.04, 0.4, 4.0 parts/10(6) selenium (Se) or 10 per cent calf serum. Collagen synthesis, measured after labelling with [3H]-proline for the last 24 h of culture, was most active at 0.4 parts/10(6) Se. Supplementation with 300 parts/10(6) Se for the first 24 h of culture caused ultrastructural changes in newly-deposited enamel and dentine matrices.
Rahkamo
A
A
Pöyry
S
S
Tuompo
H
H
D000565:Ameloblasts / Q000648:ultrastructure; D000818:Animals; D051379:Mice; D008854:Microscopy, Electron; D008963:Molar / Q000648:ultrastructure; D009804:Odontoblasts / Q000648:ultrastructure; D009924:Organ Culture Techniques; D012643:Selenium / Q000494:pharmacology*; D014070:Tooth / Q000187:drug effects*
D012643:Selenium