title: Serum CA 125 in epithelial ovarian cancer. A longitudinal study.
abstract: Plasma levels of CA 125 were determined in 113 patients with ovarian cancer of epithelial origin. Of these, 69 patients had CA 125 measured before the first laparotomy and 84.6% of them had a CA 125 level greater than 35 U/ml. In 87 of the 113 patients whose tumour was producing CA 125, a good correlation was observed between the CA 125 levels and the clinical follow-up: 95.7% of the patients in remission had levels less than 35 U/ml, whereas all the patients with no change or with a progressive disease had levels greater than 35 U/ml. Furthermore in recurrent disease the levels of CA 125 were also increased (greater than 35 U/ml) in 92.3% of the patients. Thus, CA 125 measurements at regular intervals are of great clinical value in following the evolution of a tumour or the success of a therapy, but unfortunately do not allow detection of an ovarian tumour at an early stage.
authors.forename: P A
authors.initials: PA
authors.lastname: Brioschi
authors.forename: O
authors.initials: O
authors.lastname: Irion
authors.forename: P
authors.initials: P
authors.lastname: Bischof
authors.forename: M
authors.initials: M
authors.lastname: Bader
authors.forename: M
authors.initials: M
authors.lastname: Forni
authors.forename: F
authors.initials: F
authors.lastname: Krauer
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology; D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate; D004715:Endometriosis / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood* / Q000473:pathology; D010053:Ovary / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate