Haptoglobin type and liver disease.
The haptoglobin phenotype has been estimated in patients suffering from chronic liver disease (n = 222) and acute hepatitis (n = 59) in comparison with the haptoglobin pattern of a normal population (n = 1726). The frequency of Hp 1-1 was significantly increased in non-alcoholic chronic liver disease (p = 5%; chi 2-test) in contrast to alcoholic disease. The highest incidence of Hp 1-1 occurred in cryptogenic cases (p = 1%). The follow-up of patients suffering from acute hepatitis failed to indicate any relationship between the haptoglobin phenotype and the course of hepatitis. The results suggest that Hp 1-1 is a genetic marker of special kinds of chronic liver diseases.
Zipprich
B
B
Giebelmann
R
R
Tolani
K
K
Schmidt
W
W
Königstedt
B
B
Scheibe
E
E
Nilius
R
R
D000208:Acute Disease; D002908:Chronic Disease; D005819:Genetic Markers; D006242:Haptoglobins / Q000235:genetics*; D006505:Hepatitis / Q000235:genetics; D006801:Humans; D008107:Liver Diseases / Q000235:genetics*; D010641:Phenotype
D005819:Genetic Markers; D006242:Haptoglobins