title: An acquired Robertsonian translocation in prolymphocytic leukemia: a case presentation and review.
abstract: Robertsonian translocations between the acrocentric autosomes are the most common type of constitutional chromosome rearrangement in humans. However, Robertsonian translocations are very rarely acquired in cancer cells. We report a patient with prolymphocytic leukemia and an acquired Robertsonian translocation in the leukemic cells. The translocation was between chromosomes #13 and #15; t(13;15)(q11;p12). Two other cases of malignancy with an acquired Robertsonian translocation have been found, one being of the t(13;15) type, which accounts for only 1% of constitutional Robertsonian translocations. We propose, therefore, that although Robertsonian translocations are occasionally observed in cancer cells, they are very rarely acquired.
authors.forename: R
authors.initials: R
authors.lastname: Morgan
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
authors.forename: V
authors.initials: V
authors.lastname: Jarzabek
authors.forename: P
authors.initials: P
authors.lastname: Scheerer
authors.forename: F
authors.initials: F
authors.lastname: Hecht
mesh_terms: D002882:Chromosomes, Human, Pair 13; D002884:Chromosomes, Human, Pair 15; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
chemical_list: D005819:Genetic Markers