[Reaction of the system of specific cortisol transport to a hemoblastosis process].
The nature of interaction of cortisol with corticosteroid-binding globulin was studied in the blood plasma of normal subjects and patients with leukemia and lymphoma. Sex-dependent differences in cortisol interaction with corticosteroid-binding globulin were found in hemoblastosis patients. Male patients showed a decrease in the binding capacity of corticosteroid-binding globulin and an increase in the affinity constant and index of free cortisol. In females no significant changes were observed.
Goncharova
N D
ND
Goncharov
N P
NP
Lebedev
V N
VN
D000208:Acute Disease; D000328:Adult; D001692:Biological Transport; D005260:Female; D006689:Hodgkin Disease / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007938:Leukemia / Q000097:blood; D007945:Leukemia, Lymphoid / Q000097:blood; D007951:Leukemia, Myeloid / Q000097:blood; D008232:Lymphoproliferative Disorders / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D012727:Sex Characteristics; D014156:Transcortin / Q000378:metabolism
D014156:Transcortin; D006854:Hydrocortisone
Reaktsiia sistemy spetsificheskogo transport kortizola na gemoblastoznyĭ protsess.