title: Effect of cis-platinum treatment on 67Ga-citrate localization and elimination in rabbits.
abstract: The treatment of rabbits with a typical dosage schedule of the chemotherapeutic drug cis-platinum resulted in an increased whole body retention of 67Ga-citrate due to decreased urinary and fecal excretion. The biodistribution of the tracer was also affected with most tissues showing greater accumulation. These changes are primarily related to drug-induced renal dysfunction, but other factors may also be involved.
authors.forename: T R
authors.initials: TR
authors.lastname: Sykes
authors.forename: A A
authors.initials: AA
authors.lastname: Noujaim
authors.forename: L G
authors.initials: LG
authors.lastname: Stephens-Newsham
authors.forename: B C
authors.initials: BC
authors.lastname: Lentle
authors.forename: A R
authors.initials: AR
authors.lastname: Turner
authors.forename: P K
authors.initials: PK
authors.lastname: Ng
authors.forename: H R
authors.initials: HR
authors.lastname: Hooper
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000378:metabolism / Q000494:pharmacology*; D005243:Feces / Q000032:analysis; D005260:Female; D005710:Gallium Radioisotopes / Q000378:metabolism* / Q000652:urine; D008297:Male; D011817:Rabbits; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D005710:Gallium Radioisotopes; D002945:Cisplatin