title: Localization of the human haptoglobin genes distal to the fragile site at 16q22 using in situ hybridization.
abstract: The distamycin A-sensitive fragile site fra(16)(q22) is a precisely localized chromosomal marker. When expressed at metaphase, it visibly separates the chromosome material on either side of the fragile site. Using a cDNA probe encoding both the alpha and beta haptoglobin chains, the haptoglobin loci were found by in situ hybridization to be distal to fra(16)(q22).
authors.forename: R N
authors.initials: RN
authors.lastname: Simmers
authors.forename: I
authors.initials: I
authors.lastname: Stupans
authors.forename: G R
authors.initials: GR
authors.lastname: Sutherland
mesh_terms: D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002874:Chromosome Mapping; D002902:Chromosomes, Human, 16-18; D004247:DNA / Q000235:genetics; D005819:Genetic Markers; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D009693:Nucleic Acid Hybridization
chemical_list: D005819:Genetic Markers; D006242:Haptoglobins; D004247:DNA