title: Prostaglandin release following Nd:YAG iridotomy in rabbits.
abstract: In this study, iridotomies were performed in nine rabbit eyes using an Nd:YAG laser at 5.2 mJ, three pulses/burst, for one burst. Prostaglandin E2 (PGE2) in aqueous humor obtained at timed intervals after treatment was then measured using a sensitive and specific radioimmunoassay. Concentrations of PGE2 (mean +/- SD pg/ml) were: pretreatment, 377 +/- 89; 30 minutes, 1858 +/- 241; 120 minutes, 735 +/- 308; and 240 minutes, 401 +/- 59, postoperatively. The release of PGE2 into the aqueous humor parallels the rise in intraocular pressure following Nd:YAG iridotomies in rabbits and thus may contribute to this phenomenon.
authors.forename: R
authors.initials: R
authors.lastname: Gailitis
authors.forename: G A
authors.initials: GA
authors.lastname: Peyman
authors.forename: J
authors.initials: J
authors.lastname: Pulido
authors.forename: M D
authors.initials: MD
authors.lastname: Mitchell
authors.forename: R M
authors.initials: RM
authors.lastname: Weinreb
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D015232:Dinoprostone; D007498:Iris / Q000601:surgery*; D053685:Laser Therapy; D008297:Male; D011184:Postoperative Period; D011458:Prostaglandins E / Q000378:metabolism*; D011817:Rabbits; D011863:Radioimmunoassay
chemical_list: D011458:Prostaglandins E; D015232:Dinoprostone