The influence of thymus factor X (TFX) and of anti-TFX globulin on the growth of Lewis lung carcinoma in mice.
The influence of thymus factor X--TFX (Polfa) and an anti-TFX rabbit gammaglobulin (RATFX) on the growth of Lewis lung carcinoma in mice was studied. The preparations were administered subcutaneously into the peritumoral region. Tumor growth was significantly retarded in the RATFX-treated groups, while a low dose TFX therapy was ineffective. No significant differences in peritumoral inflammatory reaction in treated and untreated mice were found.
Frackowiak
J
J
Department of Physiopathology, Medical Academy, Gdańsk.
Zółtowska
A
A
Gan
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000502:physiology*; D002455:Cell Division; D007136:Immunoglobulins / Q000008:administration & dosage / Q000502:physiology*; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology* / Q000628:therapy; D011817:Rabbits; D013935:Thymic Factor, Circulating / Q000008:administration & dosage / Q000276:immunology / Q000502:physiology*; D013951:Thymus Hormones / Q000502:physiology*
D000970:Antineoplastic Agents; D007136:Immunoglobulins; D013951:Thymus Hormones; D013935:Thymic Factor, Circulating