[Effect of beta-mercaptoethylamine on tryptophan hydroxylase activity in rat tissues].
The ability of amine-producing tissues (liver tissue, small intestine, mast cells) of rats to synthesize 5-hydroxytryptophan in response to irradiation and their involvement in creation of endogenous radioresistance was studied. Administration of a thiol radioprotector beta-mercaptoethylamine resulted in alteration of kinetic properties of tryptophane hydroxylase expressed as a decrease in the optimal concentration of the substrate; this decrease was more distinct in liver and small intestine as compared with mast cells.
Graevskaia
E E
EE
Lomakin
N N
NN
Mineeva
M F
MF
Goncharenko
E N
EN
D000818:Animals; D002478:Cells, Cultured; D004789:Enzyme Activation; D007700:Kinetics; D008297:Male; D008624:Mercaptoethylamines / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013379:Substrate Specificity; D014018:Tissue Distribution; D014365:Tryptophan Hydroxylase / Q000378:metabolism*
D008624:Mercaptoethylamines; D011837:Radiation-Protective Agents; D014365:Tryptophan Hydroxylase
Vliianie beta-merkaptoétilamina na triptofangidroksilaznuiu aktivnost' v tkaniakh krys.