title: Prevalence of hepatitis B virus markers among Ethiopian blood donors: is HBsAg screening necessary?
abstract: Four hundred and fifty-nine Ethiopian volunteer blood donors were prospectively studied for hepatitis B virus (HBV) and Delta agent infections. The prevalence of hepatitis B surface antigen (HBsAg) was 11%, anti-HBs and only anti-HBc 66% and 2%, respectively. Thus, the total HBV infection rate was 79%. There was a single donor with antibody against Delta antigen. The rarity of HBeAg among HBsAg carriers, the lack of occurrence of factors favouring transmission and risk calculations using the available data indicate that post-transfusion hepatitis due to HBV is unlikely to be common in this highly endemic country with very limited financial resources allocated for health services. Thus, we question the validity of indiscriminate screening of all donated blood and we suggest that health policies should emphasize the need for preventive measures.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Addis Ababa University, Ethiopia.
authors.forename: E
authors.initials: E
authors.lastname: Tsega
authors.forename: B
authors.initials: B
authors.lastname: Mengesha
authors.forename: E
authors.initials: E
authors.lastname: Nordenfelt
authors.forename: B G
authors.initials: BG
authors.lastname: Hansson
authors.forename: J
authors.initials: J
authors.lastname: Lindberg
mesh_terms: D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D001782:Blood Donors; D002353:Carrier State / Q000175:diagnosis / Q000453:epidemiology; D005002:Ethiopia; D006509:Hepatitis B / Q000175:diagnosis / Q000517:prevention & control* / Q000635:transmission; D006510:Hepatitis B Antibodies / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis* / Q000276:immunology; D006801:Humans; D008403:Mass Screening
chemical_list: D000956:Antigens, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens