Results of bronchial challenge after infantile obstructive bronchitis.
The bronchial hyperreactivity was examined in a follow-up of 206 children having had obstructive bronchitis before two years of age. The acetylcholine challenge was done with 0.5% and 1% Pharmalgen solutions. The bronchial hyperreactivity was established over a 20% decrease of PEF and/or FEV1 values. Summarizing the results produced by 0.5% and 1% solutions a significant difference could be found in the bronchial hyperreactivity between the follow-up and control groups. Similarly the PC20 (provocative concentrations) values were suitable for differentiating the two groups. Upon physical exercise, EIB occurred in 2%. With the skin prick test (SPT) by 10 allergens 3+ or 4+ positivity was found in 17% of the children. Between the bronchial hyperreactivity and SPT positivity a significant correlation could be established.
Póder
G
G
First Department of Paediatrics, Semmelweis University Medical School, Budapest, Hungary.
Kelemen
J
J
Mezei
G
G
Börzsönyi
L
L
D000109:Acetylcholine; D001249:Asthma / Q000175:diagnosis*; D001985:Bronchial Provocation Tests; D001986:Bronchial Spasm / Q000175:diagnosis; D001991:Bronchitis / Q000503:physiopathology*; D002648:Child; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D013997:Time Factors
D000109:Acetylcholine