title: A prospective, randomized study of 5-fluorouracil and filtration surgery.
abstract: Our study shows that use of a small dose of subconjunctival 5-FU provides significantly lower postoperative intraocular pressure than does no antimetabolite treatment. Morphology of the postoperative blebs suggests that increased filtration results in lower intraocular pressure in the 5-FU group. Corneal epithelial defects were as common with a low dose as with higher doses previously described.
authors.affiliation: Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois.
authors.forename: J M
authors.initials: JM
authors.lastname: Ruderman
authors.forename: D B
authors.initials: DB
authors.lastname: Welch
authors.forename: M F
authors.initials: MF
authors.lastname: Smith
authors.forename: D E
authors.initials: DE
authors.lastname: Shoch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D005901:Glaucoma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D011897:Random Allocation
chemical_list: D005472:Fluorouracil