title: The gene encoding for the major brain proteolipid (PLP) maps on the q-22 band of the human X chromosome.
abstract: Recombinant plasmid clone p23 containing the cDNA proteolipid (PLP) sequence was localized by in situ hybridization on band q22 of the human X chromosome. This localization may have implications for X-linked demyelination diseases such as Pelizaeus-Merzbacher disease in man.
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: P M
authors.initials: PM
authors.lastname: Alliel
authors.forename: A
authors.initials: A
authors.lastname: Dautigny
authors.forename: E
authors.initials: E
authors.lastname: Passage
authors.forename: D
authors.initials: D
authors.lastname: Pham-Dinh
authors.forename: J F
authors.initials: JF
authors.lastname: Mattei
authors.forename: P
authors.initials: P
authors.lastname: Jollès
mesh_terms: D001923:Brain Chemistry; D002871:Chromosome Banding; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D009693:Nucleic Acid Hybridization; D011510:Proteolipids / Q000235:genetics*; D014960:X Chromosome
chemical_list: D005819:Genetic Markers; D011510:Proteolipids; D004247:DNA