title: Effect of testosterone and anabolic steroids on the size of sebaceous glands in power athletes.
abstract: The effect of testosterone and anabolic steroids on the size of sebaceous glands was studied by means of interactive morphometry in skin biopsies of power athletes. The subjects used self-administered high doses of testosterone and anabolic steroids during a 4-week strength training period. After 4 weeks' use of hormones, the area of sectioned sebaceous glands enlarged significantly by a factor of 89.2% (p less than 0.005). The number of cells in the so-called differentiating cell pool (DCP) and in the undifferentiated cell pool (UCP) also increased significantly (p less than 0.025, p less than 0.05, respectively). The size of the area occupied by UCP cells increased significantly (p less than 0.05). The study suggests that high doses of testosterone and anabolic steroids lead to an enlargement of sebaceous glands in male power athletes.
authors.affiliation: Department of Dermatology, South-Saimaa Central-Hospital, Lappeenranta, Finland.
authors.forename: C L
authors.initials: CL
authors.lastname: Király
authors.forename: Y
authors.initials: Y
authors.lastname: Collan
authors.forename: M
authors.initials: M
authors.lastname: Alén
mesh_terms: D000328:Adult; D045930:Anabolic Agents / Q000009:adverse effects*; D001706:Biopsy; D004300:Doping in Sports; D006801:Humans; D008297:Male; D008696:Methandrostenolone / Q000009:adverse effects; D009277:Nandrolone / Q000009:adverse effects; D012627:Sebaceous Glands / Q000187:drug effects* / Q000473:pathology; D013197:Stanozolol / Q000009:adverse effects; D013739:Testosterone / Q000009:adverse effects*
chemical_list: D045930:Anabolic Agents; D013739:Testosterone; D013197:Stanozolol; D009277:Nandrolone; D008696:Methandrostenolone