Amplification and rearrangement of Hu-ets-1 in leukemia and lymphoma with involvement of 11q23.
The Hu-ets-1 oncogene was found to be rearranged and amplified 30-fold in one case of acute myelomonocytic leukemia in which a homogeneously staining region occurred on 11q23; the oncogene was rearranged and amplified approximately tenfold in a case of small lymphocytic cell lymphoma with an inverted insertion that also involved band 11q23. This work suggests that Hu-ets-1 is an unusual oncogene that can help explain the common involvement of chromosome band 11q23 in various subtypes of hematopoietic malignancies.
Rovigatti
U
U
Watson
D K
DK
Yunis
J J
JJ
D002869:Chromosome Aberrations / Q000235:genetics; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002901:Chromosomes, Human, 13-15 / Q000648:ultrastructure; D002906:Chromosomes, Human, 6-12 and X / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D014178:Translocation, Genetic
D004273:DNA, Neoplasm