Effect of retinoids on the growth of squamous cell carcinoma of the palate in rats.
The in vivo effects of retinoids on head and neck tumors were studied using Fisher 344 rats with squamous cell carcinoma implanted in the palate. Retinoids were given orally to rats, starting 2 weeks after tumor implantation. The animals were killed at 4 weeks, and the tumor volumes and body weights were measured. The animals had a greater response to all-trans-retinoic acid (58 per cent) and 13-cis-retinoic acid (60 per cent) than to all-trans-retinol (20 per cent) and 13-cis-retinal (30 per cent). Comparison of both tumor volumes and body weights among the retinoid-treated groups revealed that the body weights increased while the tumor volumes decreased. Retinoids seem to inhibit local tumor growth through their effects on host cellular and humoral immunity and through the inhibition of tumor cell keratinization.
Huang
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D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D004195:Disease Models, Animal; D004224:Diterpenes; D015474:Isotretinoin; D009368:Neoplasm Transplantation; D010157:Palatal Neoplasms / Q000188:drug therapy*; D051381:Rats; D011916:Rats, Inbred F344; D012172:Retinaldehyde / Q000494:pharmacology; D012176:Retinoids / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology
D004224:Diterpenes; D012176:Retinoids; C031338:13-cis-retinal; D014212:Tretinoin; D015474:Isotretinoin; D012172:Retinaldehyde