title: Excretion of flurbiprofen into breast milk.
abstract: The extent of flurbiprofen's excretion into mature (postcolostrum) breast milk was evaluated in 10 healthy, nursing mothers after administration of a single 100-mg tablet. Samples of milk and blood were subsequently obtained over a 48-hour period and assayed for flurbiprofen by high-performance liquid chromatography. The average peak plasma flurbiprofen concentration, 15 micrograms/ml, occurred at 1.5 hours, and the harmonic mean half-life of the drug was 5.8 hours. The average peak milk concentration of flurbiprofen was 0.09 microgram/ml, and the maximum recovery of the dose in breast milk was only 0.07%.
authors.affiliation: Pharmacokinetic/Pharmacodynamic Research Unit, Upjohn Company, Kalamazoo, Michigan 49001.
authors.forename: S R
authors.initials: SR
authors.lastname: Cox
authors.forename: K K
authors.initials: KK
authors.lastname: Forbes
mesh_terms: D000293:Adolescent; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005480:Flurbiprofen / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D008895:Milk, Human / Q000378:metabolism*; D011422:Propionates / Q000493:pharmacokinetics*
chemical_list: D011422:Propionates; D005480:Flurbiprofen