Molecular hybridization to meiotic chromosomes in man reveals sequence arrangement on the no. 9 chromosome and provides clues to the nature of "parameres".
In situ hybridization of male human meiotic material has been used to elucidate the molecular organization of the centromeric region of human chromosome 9. The use of two cloned DNA sequences has shown that the centromere and the secondary constriction of this chromosome contain two separate repeated DNA families. The secondary constriction organizes into "paramere" bodies during pachytene. The individual parameres are comprised of one family of repeated DNA sequences.
Mitchell
A R
AR
Ambros
P
P
McBeath
S
S
Chandley
A C
AC
D002503:Centromere / Q000648:ultrastructure*; D002875:Chromosomes / Q000648:ultrastructure*; D002906:Chromosomes, Human, 6-12 and X / Q000648:ultrastructure*; D004274:DNA, Recombinant; D004214:Distamycins; D005260:Female; D005819:Genetic Markers; D006570:Heterochromatin / Q000648:ultrastructure; D006801:Humans; D007211:Indoles; D008297:Male; D008540:Meiosis; D009693:Nucleic Acid Hybridization; D012091:Repetitive Sequences, Nucleic Acid
D004274:DNA, Recombinant; D004214:Distamycins; D005819:Genetic Markers; D006570:Heterochromatin; D007211:Indoles; C007293:DAPI; C030000:stallimycin