[Morphofunctional characteristics of the skin of newborn rat pups with prenatal exposure to desoxycorticosterone acetate].
Desoxycorticosterone acetate (DOCA) was injected intramuscularly to pregnant rats at the III, or II-III trimester of pregnancy. By the end of pregnancy with increasing body mass of the female rats, the hormonal dosage dropped. The newborn rat skin was studied. The prenatal effect of DOCA resulted in thinning the epidermis, the decreasing dosage in certain activation of the epithelial proliferative activity and in appearance of foci of its hyperplasia. The hormone in the dose 0.8-1.0 mcg/100 g of the body mass activates the proliferative ability of fibroblasts, elevates the quantity of tissue basophils, increases secretory activity of both of them; this produces thickening of the derm. In the microvessels morphofunctional activity of endothelium increases, in the basal membrane contents of PAS-positive substances drop, the wall is often infiltrated with lymphocytes. Correlations between the cells and other structural components of the skin intensify. When the dose of DOCA increases and the time of the injection is short, the proliferative and secretory activity of fibroblasts is inhibited, but morphofunctional properties of the tissue basophils are stimulated. Congestive phenomena develop in the microvessels, mitotic activity of endotheliocytes is inhibited, in the basal membrane amount of the PAS-positive substances sharply decreases, perivascular edema develops in the connective tissue. Weakening or imbalance of the correlations is observed.
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D000818:Animals; D000831:Animals, Newborn; D002452:Cell Count / Q000187:drug effects; D003900:Desoxycorticosterone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D010503:Periodic Acid-Schiff Reaction; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012867:Skin / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D003900:Desoxycorticosterone
Morfofunktsional'nye osobennosti kozhi novorozhdennykh krysiat pri prenatal'nom vozdeĭstvii dezoksikortikosteron-atsetatom.