Diflunisal-induced neutropenia.
We report a case of neutropenia associated with the use of diflunisal. The neutropenia occurred with initial administration and on subsequent inadvertent rechallenge with the drug. Bone marrow biopsy showed active granulopoiesis and an immune-mediated mechanism for this response is postulated.
McLean
C A
CA
Begley
C G
CG
Harris
R A
RA
D000380:Agranulocytosis / Q000139:chemically induced*; D001168:Arthritis / Q000188:drug therapy; D004061:Diflunisal / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced*; D012459:Salicylates / Q000009:adverse effects*
D012459:Salicylates; D004061:Diflunisal