Congenital monoblastic leukemia cutis. A case report with chromosomal abnormality: del (10p).
Congenital monoblastic leukemia cutis is a rare disorder. We report an infant who developed infiltrative skin lesions by 2 weeks of age, which, when biopsied at 4 1/2 months of age revealed a monoblastic infiltrate. Blasts in the peripheral blood were not seen until 1 week before her death at 8 months of age. Chromosomal analyses of her bone marrow showed an abnormal clone of cells with a 46,XX,del(10)(p12) karyotype. Although chromosome 10 is rarely involved in hematologic malignancies, abnormalities of this chromosome within the region 10p11-10p13 have now been shown in four of 10 reported cases of congenital monoblastic leukemia.
Seo
I S
IS
McGuire
W A
WA
Heerema
N A
NA
Mirkin
L D
LD
Weetman
R M
RM
D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000151:congenital* / Q000235:genetics; D012878:Skin Neoplasms / Q000151:congenital* / Q000235:genetics / Q000648:ultrastructure