Ascorbic acid, PGE2 and acetylcholine interaction: the effect on isolated smooth muscle.
The action of L-ascorbic acid (AA) on the isolated rat stomach fundus and guinea pig ileum was studied. AA induced contractions of these organs and potentiated the effect of ACh and PGE2. The contractile effect of AA was potentiated by eserine and inhibited by atropine. Dose-response relations suggest a stimulatory effect of AA on the muscarinic receptor.
Poćwiardowska-Ciara
E
E
Korolkiewicz
Z
Z
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D015232:Dinoprostone; D004347:Drug Interactions; D005260:Female; D005748:Gastric Fundus / Q000187:drug effects; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011458:Prostaglandins E; D015232:Dinoprostone; D000109:Acetylcholine; D001205:Ascorbic Acid