[Fibrous dysplasia and ossifying fibroma. Morphologic criteria].
Among a series of 42 ossifying fibromas and 32 fibrous dysplasias, 5 cases were studied by histoenzymological and electron microscopic methods. The histological study in 2/3 of cases is sufficient for the diagnosis between the two diseases: trabecular bone in a connective tissue with regular collagen fibres in the ossifying fibroma; nodular indented bony areas with irregular collagen frame in fibrous dysplasia. By histoenzymology, the diagnosis between the two affections is not easy: same activity of ATPases and alkaline phosphatases in fibroblasts and osteoblasts. By electron microscopy, the morphology of the two lesions is different: in ossifying fibroma, numerous well-differentiated osteoblasts and large areas of ossification are seen; in fibrous dysplasia, undifferentiated cells are numerous and the collagen frame is irregularly mineralized. This method is also useful for the histogenetic understanding of these two osteopathies.
Chomette
G
G
Auriol
M
M
Boisnic
S
S
Guilbert
F
F
Vaillant
J M
JM
D003094:Collagen; D003937:Diagnosis, Differential; D005147:Facial Bones / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D005347:Fibroblasts / Q000473:pathology / Q000648:ultrastructure; D005350:Fibroma / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D005357:Fibrous Dysplasia of Bone / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D008648:Mesoderm / Q000166:cytology; D010006:Osteoblasts / Q000473:pathology / Q000648:ultrastructure; D010011:Osteocytes / Q000473:pathology / Q000648:ultrastructure; D010016:Osteoma / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D010088:Oxidoreductases / Q000378:metabolism; D012888:Skull Neoplasms / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure
D003094:Collagen; D010088:Oxidoreductases
Dysplasie fibreuse et fibrome ossifiant. Critères morphologiques.