title: Impaired monocyte function in glycogen storage disease type Ib.
abstract: Phagocyte (neutrophil and monocyte) function was evaluated in a boy with glycogen storage disease type Ib. Neutrophils were found to be defective in motility and respiratory burst and monocytes showed a defect in respiratory burst but not in motility. These results suggested that the glucose-6-phosphate transport system plays a role in the function of neutrophils and monocytes and that these two phagocytes are different from each other in their energy metabolism for motility.
authors.forename: N
authors.initials: N
authors.lastname: Ueno
authors.forename: M
authors.initials: M
authors.lastname: Tomita
authors.forename: T
authors.initials: T
authors.lastname: Ariga
authors.forename: M
authors.initials: M
authors.lastname: Ohkawa
authors.forename: S
authors.initials: S
authors.lastname: Nagano
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Arashima
authors.forename: S
authors.initials: S
authors.lastname: Matsumoto
mesh_terms: D000293:Adolescent; D001853:Bone Marrow / Q000473:pathology; D002478:Cells, Cultured; D005953:Glycogen Storage Disease Type I / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D009000:Monocytes / Q000502:physiology*; D010587:Phagocytosis
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M