[Effect of ethanol and the catalase inhibitor aminotriazole on the activity of antioxidative enzymes in the rat liver and heart].
Tissue-specific effects of ethanol and aminotriazole were studied in rats. Simultaneous administration of both these drugs caused alcoholic cardiomyopathy in the animals, while liver tissue impairment was not detected. Effect of ethanol and aminotriazole on content of reduced glutathione as well as on activity of catalase, superoxide dismutase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase, the enzymes participating in the antioxidation system, were also studied in liver and heart tissues. After repeated simultaneous or separate administration of these drugs concentration of glutathione and glutathione-S-transferase activity were elevated in liver tissue. Acute and repeated administration of a notriazole led to inactivation of catalase the same time, superoxide dismutase was inhibited in liver tissue as a result of the drug repeated administration. Activity of glucose phosphate dehydrogenase was increased in liver tissue of control rats, the diet of which contained isocaloric carbohydrates instead of ethanol.
Antonenkov
V D
VD
Gusev
V A
VA
Krasnova
S N
SN
D000640:Amitrole / Q000633:toxicity*; D000818:Animals; D002374:Catalase / Q000037:antagonists & inhibitors*; D000431:Ethanol / Q000633:toxicity*; D008099:Liver / Q000201:enzymology*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D014230:Triazoles / Q000633:toxicity*
D014230:Triazoles; D000431:Ethanol; D002374:Catalase; D000640:Amitrole
Vliianie étanola i ingibitora katalazy aminotriazola na aktivnost' fermentov antiokislitel'noĭ zashchity v pecheni i serdtse krys.