title: Chromosome abnormalities in meningiomas.
abstract: Cytogenetic analyses of eight meningiomas grown in culture for 1 week are reported. Normal karyotypes were found in three cases and hypodiploidy in the remaining five. In the five hypodiploid meningiomas, one chromosome #22 was missing in four cases, and one case exhibited a 22q- deletion. In four of these five cases, chromosome #14 was either lost or altered. Chromosome #1 was lost or altered in three, and chromosome #6 in two. These findings lend further support for the association of total or partial loss of chromosome #22 in meningiomas and suggest the involvement of other chromosomes in the clonal evolution of these tumors.
authors.forename: J
authors.initials: J
authors.lastname: Katsuyama
authors.forename: P R
authors.initials: PR
authors.lastname: Papenhausen
authors.forename: F
authors.initials: F
authors.lastname: Herz
authors.forename: P
authors.initials: P
authors.lastname: Gazivoda
authors.forename: A
authors.initials: A
authors.lastname: Hirano
authors.forename: L G
authors.initials: LG
authors.lastname: Koss
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics*; D008579:Meningioma / Q000235:genetics*; D008875:Middle Aged; D014178:Translocation, Genetic
chemical_list: D005819:Genetic Markers