title: An experimental study of bio-availability of fluoride from dietary sources in man.
abstract: After single, oral doses, 8 h profiles of fluoride (F) concentrations in plasma and saliva, and 24 h urinary excretions were determined in healthy adult volunteers. Bio-availability of F from dietary sources was evaluated in relation to that of NaF. Between 2 and 10 mg of F administered all 3 variables were dose-dependent. However, digestion, the chemical state of F, and interaction with accompanying foods may modify the kinetics of F passage through the human body. Low bio-availabilities were observed for most solid foods such as fish and algal flour and for mammalian and fish bones, when used as typical components of fluoride-rich foods such as meat- and fish-products. This data is important in the determination of optimum levels of F supplementation in human nutrition for caries-prevention programmes.
authors.forename: K
authors.initials: K
authors.lastname: Trautner
authors.forename: G
authors.initials: G
authors.lastname: Siebert
mesh_terms: D000328:Adult; D001682:Biological Availability; D004032:Diet; D005459:Fluorides / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006801:Humans; D008875:Middle Aged; D012463:Saliva / Q000032:analysis; D012969:Sodium Fluoride / Q000378:metabolism
chemical_list: D012969:Sodium Fluoride; D005459:Fluorides