[Immunoglobulin administration as infection prevention in oncologic patients].
Children receiving cytotoxic drugs were given 7 S IgG or placebo before the period of neutropenia (less than 500/mm3 neutrophils) in a double-blind study. Though the IgG levels differed significantly, fever as the most reliable sign of infection occurred not less often than in the placebo-group. There is no indication for the routinely prophylactic administration of immunoglobulins to oncological patients. The therapeutic benefit of immunoglobulin substitution in cancer patients needs verification.
Bode
U
U
Erps
M
M
Liappis
N
N
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007108:Immune Tolerance; D007116:Immunization, Passive; D007070:Immunoglobulin A / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000276:immunology; D009369:Neoplasms / Q000150:complications* / Q000276:immunology; D009503:Neutropenia / Q000628:therapy; D009894:Opportunistic Infections / Q000276:immunology / Q000517:prevention & control*
D007070:Immunoglobulin A; D007075:Immunoglobulin M
Immunglobulingabe als Infektionsprophylaxe onkologischer Patienten?