Cyclosporin A in steroid-sensitive nephrotic syndrome with frequent relapses.
Eight patients with steroid-sensitive nephrotic syndrome which frequently relapsed despite cyclophosphamide treatment were given cyclosporin A (7.5 mg/kg/day to 10 mg/kg/day) for 8 to 12 weeks. Six had minimal change glomerulonephritis and two had focal segmental glomerulonephritis. Cyclosporin A was given to 5 patients when their nephrotic syndrome was in relapse and to 3 patients when the nephrotic syndrome was in remission. Cyclosporin A induced a transient remission in only one patient.
Chan
M K
MK
Department of Medicine, University of Hong Kong, Queen Mary Hospital.
Cheng
I K
IK
D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use; D003524:Cyclosporins / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009402:Nephrosis, Lipoid / Q000150:complications; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000209:etiology; D012008:Recurrence
D003524:Cyclosporins; D005938:Glucocorticoids; D003520:Cyclophosphamide