title: Chronic trichloroethylene intoxication: a new approach by trigeminal-evoked potentials?
abstract: Trigeminal nerve impairment is frequently seen in chronic trichlorethylene intoxication (TRI). A total of 104 occupationally exposed subjects were selected for study because they were employed at a highly exposed workplace. They were studied by clinical examination and by trigeminal somatosensory evoked potentials (TSEP). Normal values for TSEP were obtained from the study of 52 healthy nonexposed subjects. Facial hypoesthesia, when present, was global and predominant in the mandibular and maxillary nerve areas, associated or not with absent reflexes. A disturbed TSEP was found in 40 subjects which was predictable from their clinical symptoms. Correlation with exposure parameters (duration of exposure, trichlorethanol, and trichloracetic acid urinary rates) was mainly observed in subjects presenting both clinical and electrical alterations. Electrical alterations alone were less predictive. An abnormal TSEP may thus provide objective determination of risk assessment in the absence of clinical signs.
authors.affiliation: Department of Toxicology, CHU Grenoble, France.
authors.forename: L
authors.initials: L
authors.lastname: Barret
authors.forename: S
authors.initials: S
authors.lastname: Garrel
authors.forename: V
authors.initials: V
authors.lastname: Danel
authors.forename: J L
authors.initials: JL
authors.lastname: Debru
mesh_terms: D000328:Adult; D003389:Cranial Nerve Diseases / Q000139:chemically induced / Q000503:physiopathology; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000503:physiopathology; D014238:Trichloroacetic Acid / Q000652:urine; D014241:Trichloroethylene / Q000009:adverse effects* / Q000652:urine; D014276:Trigeminal Nerve / Q000187:drug effects*
chemical_list: D014241:Trichloroethylene; D014238:Trichloroacetic Acid