Biochemical and morphometric analysis of the effect of spironolactone on the livers from immature and adult rats.
Biochemical and morphometric studies were carried out to characterize the effect of spironolactone (SP) on liver tissue from immature and adult young rats: 1. The SP produced an increase in total protein in all the groups. 2. Hypertrophy in 24 days-old rats. 3. Hypertrophy and hyperplasia in 48 days-old rats. 4. The morphometric studies were correlated to the biochemical parameters.
Guibert
E E
EE
Instituto de Fisiologia Experimental, Conicet, Universidad Nacional de Rosario, Argentina.
Rodriguez
J V
JV
Garcia
G
G
Rodriguez Garay
E A
EA
D000375:Aging / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D003593:Cytoplasm / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D046911:Macromolecular Substances; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013148:Spironolactone / Q000494:pharmacology*
D046911:Macromolecular Substances; D013148:Spironolactone