title: Role of brain prostaglandins in the control of vasopressin secretion in the conscious rat.
abstract: Administration of 10 micrograms prostaglandin D2 (PGD2), the primary PG identified in the rat brain, into the lateral cerebral ventricle of conscious rats resulted in a significant elevation in the plasma vasopressin (AVP) concentration, without a change in mean arterial blood pressure or heart rate. The central administration of indomethacin (100 micrograms) resulted in a significant attenuation of the AVP response to a peripheral osmotic stimulus (iv 2.5 M NaCl; 100 microliters/kg X min for 30 min), but had little effect on the AVP response to hemorrhage (two successive 10% reductions in the estimated blood volume). Administration of another PG synthetase inhibitor, meclofenamate (100 micrograms, into the lateral cerebral ventricle), resulted in a significant attenuation of the AVP response to both the osmotic stimulus and hemorrhage. It is concluded that brain PGs play a central role in the control of AVP secretion.
authors.forename: D P
authors.initials: DP
authors.lastname: Brooks
authors.forename: L
authors.initials: L
authors.lastname: Share
authors.forename: J T
authors.initials: JT
authors.lastname: Crofton
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D008469:Meclofenamic Acid / Q000494:pharmacology; D015230:Prostaglandin D2; D011453:Prostaglandins / Q000502:physiology*; D011457:Prostaglandins D / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014667:Vasopressins / Q000378:metabolism*
chemical_list: D011453:Prostaglandins; D011457:Prostaglandins D; D014667:Vasopressins; D001127:Arginine Vasopressin; D008469:Meclofenamic Acid; D015230:Prostaglandin D2; D007213:Indomethacin