Evidence of digoxin metabolism by the kidney.
By performing single pass experiments in the dog, we could identify by thin layer chromatography a digoxin metabolite produced by the kidney. In vitro studies verify that this new species is produced by the brush border membrane of the renal tubular cell.
Koren
G
G
Department of Pediatrics, Hospital for Sick Children, Toronto, Ont., Canada.
Klein
J
J
Silverman
M
M
D000818:Animals; D002855:Chromatography, Thin Layer; D004077:Digoxin / Q000378:metabolism* / Q000652:urine; D004285:Dogs; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism*; D007672:Kidney Cortex / Q000378:metabolism; D008297:Male; D008871:Microvilli / Q000378:metabolism
D004077:Digoxin