Tissue levels of ofloxacin in the urogenital system.
The authors evaluated the tissue levels of ofloxacin in 63 patients with urogenital diseases, in comparison to the minimum inhibitory concentrations 80% (MIC80) of some strains. The drug was administered in a single dose (300 mg) about 3 hours before surgery. After washing carefully, the tissue-levels were measured by using the HPLC method. In the normal renal parenchyma of 8 patients, the mean value was 22.10 micrograms/g of tissue; 19.23 micrograms/g in 13 patients with deranged excretory pathways; 10.62 micrograms/g in 25 patients with benign prostatic hypertrophy; 10.90 micrograms/g in 14 deferent duct patients. These results indicate that the drug is promptly distributed in various tissues of the urinary-genital apparatus at high concentrations.
di Silverio
F
F
Cruciani
E
E
Ferrone
G
G
de Marco
F
F
Lauretti
S
S
Prencipe
M G
MG
D000328:Adult; D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000652:urine; D001419:Bacteria / Q000187:drug effects; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015242:Ofloxacin; D010078:Oxazines / Q000378:metabolism* / Q000652:urine; D011467:Prostate / Q000378:metabolism; D014566:Urogenital System / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D010078:Oxazines; D015242:Ofloxacin