Cardiovascular effects of leukotriene C4 and D4 in the anesthetized and conscious domestic hen.
In anesthetized and conscious domestic hens i.v. injections of LTC4 (1 and 3 micrograms/hen) and LTD4 (0.1-10 micrograms/hen) induced a pronounced hypotension, initially interrupted by a small, upward pressure deflection. No significant changes in HR, ECG-characteristics, or hematocrit were observed. It is concluded that neither plasma leakage nor myocardial ischemia are likely to contribute significantly to the hypotension. Only experiments with LTD4 in conscious hens suggest a mediator function of cyclooxygenase products since the LTD4-induced hypotension was attenuated by IND. The failure of developing reflex tachycardia rather points to an impairment with manifestation of reflex mechanisms.
Wechsung
E
E
Houvenaghel
A
A
D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002645:Chickens / Q000502:physiology*; D003243:Consciousness; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007022:Hypotension / Q000139:chemically induced; D007213:Indomethacin / Q000494:pharmacology; D007275:Injections, Intravenous; D010121:Oxytocin / Q000494:pharmacology; D013189:SRS-A / Q000008:administration & dosage / Q000494:pharmacology*
D013189:SRS-A; D010121:Oxytocin; D007213:Indomethacin