The role of arginine-vasopressin in the regulation of water metabolism in preterm infants in the first days of life.
We studied the role of arginine-vasopressin (AVP) in the regulation of fluid homeostasis in preterm infants. Group 1 was fed orally, groups 2 and 3 received fluids parenterally, and group 3 developed respiratory distress syndrome (RDS) and had to be ventilated. The infants of group 3 were not able to excrete the administered fluid, gained weight and consecutively developed hyponatremia. 1-min Apgar scores as well as log FiO2 correlated significantly with urinary AVP excretion on day 1. We conclude that nonosmotic stimuli are involved in the release of AVP and therefore disturb fluid homeostasis in severely ill infants with RDS.
Stegner
H
H
Department of Pediatrics, University Hospital, Hamburg, FRG.
Henkel
R
R
Commentz
J C
JC
D001127:Arginine Vasopressin / Q000502:physiology* / Q000652:urine; D005865:Gestational Age; D006706:Homeostasis; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D014882:Water-Electrolyte Balance
D001127:Arginine Vasopressin