HLA-DR effects in a large German IDDM dataset.
DR4 and DR3 are in strongest linkage disequilibrium with IDDM susceptibility genes, and DR1 demonstrates a lesser degree of positive disequilibrium. DR3/DR4 heterozygotes have the highest risk. The DR1 increase occurs almost exclusively in DR4/DR1 heterozygotes, suggesting that DR1 may be in disequilibrium with the same susceptibility gene as DR3. Homozygotes for DR4 and especially DR3 have a higher risk than heterozygotes of either with DRX. GLO-2 is increased in diabetic haplotypes carrying DR4, DR3 or DR1.
Field
L L
LL
Fothergill-Payne
C
C
Bertrams
J
J
Baur
M P
MP
D000483:Alleles; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D004198:Disease Susceptibility; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D005860:Germany, West; D006680:HLA Antigens / Q000235:genetics; D006681:HLA-D Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D013869:Thiolester Hydrolases / Q000235:genetics; D000099301:Hydroxyacylglutathione Hydrolase
D005819:Genetic Markers; D006680:HLA Antigens; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D013869:Thiolester Hydrolases; D000099301:Hydroxyacylglutathione Hydrolase