SHBG, testosterone, androstenedione, 17-OH-Progesterone plasma levels in PCO affected women treated with a triphasic oral contraceptive.
A triphasic oral contraceptive Trigynon (Schering) or Triphasil (Wyeth) was administered to 13 anovulatory women with hyperandrogenism, enlarged polycystic ovaries and reversal of LH/FSH ratio. After three months of treatment total Testosterone, Androstenedione and 17-OH-Progesterone levels significantly decreased while SHBG significantly increased. Reduction of hair growth and improvement of acne were noted. Side effects were minimal.
Negri
P
P
Istituto di Clinica Ostetrica e Ginecologica dell'Università degli Studi di Ferrara.
Agnello
G
G
Borghesani
F
F
Tomain
L
L
Minisci
N
N
D'Errico
G
G
Cavallini
A R
AR
D019326:17-alpha-Hydroxyprogesterone; D000293:Adolescent; D000328:Adult; D000735:Androstenedione / Q000097:blood*; D003280:Contraceptives, Oral, Synthetic / Q000627:therapeutic use*; D004997:Ethinyl Estradiol / Q000627:therapeutic use*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood*; D009644:Norgestrel / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013739:Testosterone / Q000097:blood*
D003280:Contraceptives, Oral, Synthetic; D006908:Hydroxyprogesterones; D012738:Sex Hormone-Binding Globulin; D009644:Norgestrel; D013739:Testosterone; D000735:Androstenedione; D004997:Ethinyl Estradiol; D019326:17-alpha-Hydroxyprogesterone; D019304:Ethinyl Estradiol-Norgestrel Combination