Acute meningitis and cerebellar dysfunction complicating high-dose cytosine arabinoside therapy.
A patient with acute lymphocytic leukemia (ALL) who was treated with high-dose cytosine arabinoside (Ara-C) 3 g/m2 twice daily, developed reversible acute aseptic meningitis and signs of cerebellar dysfunction after a total dose of 24 g Ara-C. To our knowledge this is the first case report of meningitis complicating intravenous high-dose Ara-C therapy.
Thordarson
H
H
Talstad
I
I
D000208:Acute Disease; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D002526:Cerebellar Diseases / Q000139:chemically induced*; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008581:Meningitis / Q000139:chemically induced*; D008582:Meningitis, Aseptic / Q000139:chemically induced*
D003561:Cytarabine