title: Chromosome studies in inherited nonpolyposis colon cancer syndrome.
abstract: This study was designed to determine if any constitutional chromosomal markers were linked with the expression of colorectal neoplasms in the inherited nonpolyposis colon cancer syndrome, using a number of cytogenetic techniques. High resolution G-banding in 12 affected and 17 unaffected family members did not reveal a structural chromosome abnormality. Increased C-band heteromorphism was not seen in either affected or unaffected individuals, and no heritable fragile sites were detected. Mean baseline and mitomycin C-induced sister chromatid exchanges were not elevated in affected patients compared with controls. Mapping of sister chromatid exchanges did not reveal any hot spots of exchange. A tumor cell line with the karyotype 46,XY,der(13),t(13;?)(p11;?) was established from one patient, but no constitutional abnormality of chromosome #13 was found. In addition, 11 patients with familial polyposis coli were studied with high resolution G-banding and no heteromorphism of chromosome #2 in the region 2q21.3 was detected.
authors.forename: R
authors.initials: R
authors.lastname: Lukeis
authors.forename: O M
authors.initials: OM
authors.lastname: Garson
authors.forename: F A
authors.initials: FA
authors.lastname: Macrae
authors.forename: D J
authors.initials: DJ
authors.lastname: St John
authors.forename: R H
authors.initials: RH
authors.lastname: Whitehead
mesh_terms: D002460:Cell Line; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D012854:Sister Chromatid Exchange
chemical_list: D005819:Genetic Markers