Transcriptional and post-transcriptional regulation of c-myc expression during the differentiation of murine erythroleukemia Friend cells.
c-myc RNA rapidly decreases to barely detectable levels in Friend erythroleukemia cells induced to differentiate upon the addition of dimethylsulfoxide. We show here that c-myc gene is down-regulated both at the transcriptional level presumably by a block in the elongation of primary transcripts and at the post-transcriptional level by an increase in the degradation of its mRNA.
Mechti
N
N
Piechaczyk
M
M
Blanchard
J M
JM
Marty
L
L
Bonnieu
A
A
Jeanteur
P
P
Lebleu
B
B
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D003609:Dactinomycin / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005809:Genes, Regulator; D007700:Kinetics; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics / Q000473:pathology; D007942:Leukemia, Experimental / Q000235:genetics* / Q000473:pathology; D051379:Mice; D009857:Oncogenes; D010957:Plasmids; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects
D012333:RNA, Messenger; D003609:Dactinomycin; D004121:Dimethyl Sulfoxide