Effects of estriol administration on human postmenopausal endometrium.
Forty eight women with atrophic endometrium were treated with estriol, 1 mg twice daily, by mouth for a minimum of 10 days and a maximum of 25 days. Vaginal hysterectomy was then performed and specimens were examined histologically. Results showed that estriol produces endometrial hyperplasia in 70.8% of the examined women; only 29.2% of the patients retained atrophic endometrium after treatment.
Montoneri
C
C
First Clinic of Obstetrics and Gynecology, University of Catania, Italy.
Zarbo
G
G
Garofalo
A
A
Giardinella
S
S
D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D004714:Endometrial Hyperplasia / Q000139:chemically induced / Q000473:pathology; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology; D004958:Estradiol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged
D004958:Estradiol