HLA type and survival in gastric cancer.
We studied HLA typing of 17 stage III gastric cancer patients who survived for more than 5 years after gastrectomy, in comparison with normal healthy controls and other gastric cancer patients. As a result, the long-term survivors had a high frequency of HLA-DR4 antigen compared with normal healthy controls (P less than 0.0025). This remains statistically significant after correction of the P value according to the number of HLA-DR antigens tested (corrected P value, less than 0.025), strongly suggesting that the presence of this antigen is associated with long-term survival time for postoperative stage III gastric cancer patients.
Hayashi
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R
Ochiai
T
T
D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D010641:Phenotype; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics / Q000276:immunology*
D006680:HLA Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II