[Creatine phosphokinase BB distribution in different structures of the human brain].
Regional localization of creatine phosphokinase BB was studied in postmortem human brain and its stability was shown. The content of CPK BB in different brain structures was unequal: from 0.5 mcg/mg of protein in the occipital lobe and tuber cinereum to 4.5 mcg/mg in the frontal lobe. In the regional localization of CPK BB in the postmortem brain of schizophrenia patients, some changes in isoenzyme content were found as compared to the control group. The reduction of CPK BB concentration at schizophrenia was found in the frontal lobe (45%, P less than 0.001) and s. nigra (70%, P less than 0.001); the concentration was higher in the thalamus and occipital lobe (15%, P less than 0.001), as well as in the parietal lobe, cingulate gyrus, tuber cinereum, cerebellum cortex, inferior olive--50-80%, P less than 0.001.
Burbaeva
G Sh
GSh
Aksenov
M V
MV
D000368:Aged; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D001923:Brain Chemistry / Q000187:drug effects; D003402:Creatine Kinase / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism*; D004795:Enzyme Stability / Q000187:drug effects; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000627:therapeutic use; D012016:Reference Values; D012559:Schizophrenia / Q000188:drug therapy / Q000201:enzymology
D007527:Isoenzymes; D011619:Psychotropic Drugs; D003402:Creatine Kinase
Raspredelenie kreatinfosfokinazy BB v razlichnykh strukturakh golovnogo mozga cheloveka.