title: Infertility associated with two accessory bisatellited chromosomes.
abstract: Two extra bisatellited chromosomes identified as inv dup (15) (pter----q11.2::q11.2----pter) were found in an oligoasthenospermic male. Analysis of Ag-staining in the proband and in one fertile brother with a normal karyotype revealed that nucleolar organizer region (NOR) activity was significantly increased in the patient. The frequency of satellite associations was also significantly higher in the index case, but no correlation was found between NOR activity and acrocentric associations. These results suggest that extra NOR activity and the elevated frequency of satellite associations could predispose to gametogenic impairment.
authors.forename: M A
authors.initials: MA
authors.lastname: Martín-Lucas
authors.forename: A
authors.initials: A
authors.lastname: Pérez-Castillo
authors.forename: J A
authors.initials: JA
authors.lastname: Abrisqueta
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002901:Chromosomes, Human, 13-15; D004276:DNA, Satellite / Q000032:analysis; D005819:Genetic Markers; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007621:Karyotyping; D008297:Male
chemical_list: D004276:DNA, Satellite; D005819:Genetic Markers