Kinetics of bromadiolone, anticoagulant rodenticide, in the Norway rat (Rattus norvegicus).
Rats (Rattus norvegicus) dosed orally with the rodenticide bromadiolone (0.8 and 3 mg/kg) were sacrificed in groups of 4 rats at various times up to 97 hours after administration. Bromadiolone was assayed in plasma, liver and kidney by an HPLC method. The compound disappeared slowly from the organism with a half-life of 25.7 hours for the 0.8 mg/kg dose and 57.5 hours for the 3 mg/kg. Concentrations in liver were rapidly established and were 14- to 46-fold higher than plasma concentrations. 97 hours after 3 mg/kg dose, liver concentrations were about 1.5 micrograms/g. Bromadiolone levels in kidney were slightly higher than those observed in plasma, with a longer half-life.
Kamil
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Laboratoire d'écotoxicologie, ENVL, INRA, Charbonniéres, France.
D015110:4-Hydroxycoumarins / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D005260:Female; D006207:Half-Life; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051381:Rats; D012378:Rodenticides / Q000097:blood / Q000493:pharmacokinetics*
D015110:4-Hydroxycoumarins; D012378:Rodenticides; C021636:bromadiolone