Effects of intracamerally infused prostaglandins on outflow facility in cynomolgus monkey eyes with intact or retrodisplaced ciliary muscle.
Cynomolgus monkeys with intact or surgically retrodisplaced ciliary muscle received intracameral infusion of prostaglandins (PG) E1, E2, and F2 alpha in doses yielding initial anterior chamber concentrations ranging from approximately 0.2 microM to approximately 0.2 mM. The effects on total outflow facility, as determined by two-level constant pressure perfusion, within the first 40 min after PG infusion were at most sporadic and minimal, and PGF2 alpha had no effect at any of the dosages given. Thus, these autacoids seem to exert little if any acute functional effect on the conventional outflow routes in this primate species when administered intracamerally under these experimental conditions.
Kaufman
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D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000502:physiology; D002924:Ciliary Body / Q000502:physiology*; D015237:Dinoprost; D015232:Dinoprostone; D004305:Dose-Response Relationship, Drug; D005260:Female; D007429:Intraocular Pressure / Q000187:drug effects; D008252:Macaca fascicularis; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*
D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D015232:Dinoprostone