title: Effect of hemoperfusion on the course of demyelinization processes: experimental and clinical picture.
abstract: The experiments on guinea pigs with experimental allergic encephalomyelitis showed, that hemoperfusion through fibrous and granulated activated carbon resulted in stable clinical effect solely on the early stages of the disease (10-11 days after sensitization). At the stage of advanced neurologic symptomatology the hemoperfusion proved effective when performed through binary adsorbent on the base of fibrous activated carbon and immobilized basic encephalitogenous protein. Forty nine patients with multiple sclerosis underwent 2-3 sessions of hemocarboperfusion on SKN coal with 7 day intervals. In patients at the initial stage of the disease the hemocarboperfusion was found to produce a stable and practically complete normalizing effect on the neurologic status. At the advanced stages of the disease the hemosorption eliminates only newly developed symptoms.
authors.affiliation: Department of Nervous Problems, Pavlov Medical Institute, Kavetsky Institute for Oncology Problems, Leningrad.
authors.forename: N P
authors.initials: NP
authors.lastname: Metalnikova
authors.forename: A A
authors.initials: AA
authors.lastname: Skoromets
authors.forename: N M
authors.initials: NM
authors.lastname: Gurina
authors.forename: I M
authors.initials: IM
authors.lastname: Barbas
authors.forename: G V
authors.initials: GV
authors.lastname: Lin'kova
authors.forename: E A
authors.initials: EA
authors.lastname: Gorokhov
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002606:Charcoal; D003711:Demyelinating Diseases / Q000628:therapy*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000628:therapy; D005260:Female; D006168:Guinea Pigs; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000628:therapy
chemical_list: D002606:Charcoal