[Monoblastic (M5a) form of relapse in acute myeloblastic (M2) leukemia with t(8;21)].
An exceptional case of acute myeloblastic leukemia (M2) with t(8;21) relapsed as an acute monoblastic leukemia (M5). At that time only a minority of metaphases exhibited a t(8;21) and/or abnormality of chromosome No 11 long arm whereas various other chromosomal changes were present. The existence of a relapse of M2 with t(8;21) as M5 is discussed in relation to the commitment of the cells which became leukemic, and to the possibility of a second leukemia.
Daniel
M T
MT
Bernheim
A
A
Garand
R
R
Bray
B
B
Leverger
G
G
Flandrin
G
G
Berger
R
R
D002648:Child; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000235:genetics / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000473:pathology*; D012008:Recurrence; D014178:Translocation, Genetic
Rechute sous forme monoblastique (M5a) d'une leucémie aiguë myéloblastique (M2) avec t(8;21).