title: Light and aging effects on vitamin E in the retina and retinal pigment epithelium.
abstract: Experiments were performed to determine the effects of senescence and light adaptation on vitamin E levels in the neural retina and RPE-choroid-sclera of pigmented rats. Aging resulted in significant increases in alpha-tocopherol levels in both tissues, the effect being most pronounced in the RPE-choroid-sclera. The state of light adaptation had no influence on alpha-tocopherol levels in the neural retina at any of the ages examined, whereas in the RPE-choroid-sclera, alpha-tocopherol levels were substantially higher in light-adapted than in dark-adapted animals at all three ages (12, 22, and 32 months) at which they were measured. The effect of light adaptation on RPE-choroid-scleral alpha-tocopherol levels was most pronounced in the oldest age group.
authors.affiliation: Mason Institute of Ophthalmology, University of Missouri, School of Medicine, Columbia 65212.
authors.forename: M L
authors.initials: ML
authors.lastname: Katz
authors.forename: W G
authors.initials: WG
authors.lastname: Robison
mesh_terms: D000221:Adaptation, Ocular; D000375:Aging / Q000378:metabolism*; D000818:Animals; D003623:Dark Adaptation; D008027:Light; D008297:Male; D009184:Mydriatics / Q000494:pharmacology; D013508:Ophthalmologic Surgical Procedures; D010857:Pigment Epithelium of Eye / Q000378:metabolism*; D011680:Pupil / Q000187:drug effects; D051381:Rats; D011912:Rats, Inbred ACI; D012160:Retina / Q000378:metabolism*; D014810:Vitamin E / Q000378:metabolism*
chemical_list: D009184:Mydriatics; D014810:Vitamin E