title: Brown adipose tissue is a target tissue in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced toxicity.
abstract: This paper demonstrates by electron microscopy that interscapular brown adipose tissue (IBAT) is a target tissue of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rats. Because of the known importance of IBAT in energy metabolism, it is suggested that brown adipose tissue may be a major target tissue in the toxicity of TCDD.
authors.forename: K
authors.initials: K
authors.lastname: Rozman
authors.forename: B
authors.initials: B
authors.lastname: Strassle
authors.forename: M J
authors.initials: MJ
authors.lastname: Iatropoulos
mesh_terms: D000064:Acclimatization; D002001:Adipose Tissue, Brown / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D000818:Animals; D003080:Cold Temperature; D004147:Dioxins / Q000633:toxicity*; D008297:Male; D008854:Microscopy, Electron; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins