Prednisone stimulation of erythropoiesis in leukemic children during remission.
Children with acute leukemia in remission manifest reticulocytosis and a significant increase in hemoglobin concentration (mean increment of 2.3 +/- 1.1 g/dl) following prednisone pulse therapy. This hemoglobin increment is not associated with changes in serum erythropoietin activity. It is speculated that this stimulation of red cell production may be a direct effect of steroids on erythroid progenitor cells.
Amylon
M D
MD
Perrine
S P
SP
Glader
B E
BE
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D004920:Erythropoiesis / Q000187:drug effects*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood / Q000188:drug therapy*; D011241:Prednisone / Q000627:therapeutic use*; D012156:Reticulocytes / Q000166:cytology
D006454:Hemoglobins; D011241:Prednisone