[Craniopharyngioma in children. Endocrine evaluation and treatment. Apropos of 37 cases].
Endocrine function was studied in 37 children treated for craniopharyngioma by total (22 cases) or partial (12 cases) excision and complementary or isolated irradiation (9 cases). Height deficiency was the only revealing sign in only 20% of cases. Skull X-rays showed patent abnormalities at the first examination in 36 of 37 cases. Analysis of 24 children before and after surgery helps defining the part played by surgery in endocrine deficiencies: the frequency of thyroid and GH deficiencies is poorly changed after surgery as they are most often already present before surgery. On the other hand, the frequency of corticotropin and antidiuretic deficiencies is highly increased after surgery. Gonadotropic deficiency is almost constant after surgery. The final height is greater than 2 SD in 9 of the 14 patients whose growth is completed.
Brauner
R
R
l'Unité d'Endocrinologie Pédiatrique, INSERM U 30, Paris.
Malandry
F
F
Rappaport
R
R
Pierre-Kahn
A
A
Hirsch
J F
JF
D000293:Adolescent; D001827:Body Height; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000601:surgery*; D005260:Female; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D008297:Male; D010911:Pituitary Neoplasms / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology*; D011627:Puberty; D013963:Thyroid Hormones / Q000097:blood
D013963:Thyroid Hormones
Craniopharyngiomes de l'enfant. Evaluation et traitement endocriniens. A propos de 37 cas.