Acute lymphoblastic leukemia in a child with constitutional ring chromosome 21.
This report describes a case of acute lymphoblastic leukemia with non-B, non-T, common acute lymphocytic leukemia antigen-positive blasts in a 13-year-old child with constitutional ring chromosome #21. Because ring chromosome #21 is a rare chromosomal disorder, it is likely that the leukemia transformation is related to the chromosomal anomaly.
Falchi
A M
AM
Orofino
M G
MG
Nucaro
A L
AL
De Virgiliis
S
S
Cao
A
A
D000293:Adolescent; D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics*; D008297:Male; D010375:Pedigree; D012303:Ring Chromosomes
D005819:Genetic Markers