title: The effects of nifedipine on blood flow in peripheral vascular disease of the lower limbs.
abstract: The effects of nifedipine on blood flow to the lower limb have been investigated in 19 patients with calf claudication, and in 8 patients with critical leg ischaemia, using Doppler techniques. In claudicants, common femoral artery blood flow increased by 55% after sublingual nifedipine, despite a fall in systolic blood pressure and no alteration in the ankle/brachial index. In patients with critical ischaemia given intravenous nifedipine, common femoral blood flow increased to reach a peak 90 minutes after the start of the infusion. The femoral artery pulsatility index, derived from the Doppler waveform, is a reliable guide to changes in blood volume flow.
authors.affiliation: University Department of Surgery, University of Wales College of Medicine, Cardiff.
authors.forename: R H
authors.initials: RH
authors.lastname: Morgan
authors.forename: J V
authors.initials: JV
authors.lastname: Psaila
authors.forename: P
authors.initials: P
authors.lastname: Lewis
authors.forename: W T
authors.initials: WT
authors.lastname: Davies
authors.forename: J P
authors.initials: JP
authors.lastname: Woodcock
mesh_terms: D000286:Administration, Sublingual; D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005263:Femoral Artery; D006801:Humans; D007262:Infusions, Intravenous; D007383:Intermittent Claudication / Q000188:drug therapy / Q000503:physiopathology*; D007511:Ischemia / Q000188:drug therapy / Q000503:physiopathology*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects
chemical_list: D009543:Nifedipine