title: Homing receptors for hemopoietic stem cells are lectins with galactosyl and mannosyl specificities.
abstract: Binding of hemopoietic stem cells to stroma in vitro is inhibited in the presence of galactosyl and mannosyl neoglycoproteins. This indicates that an interaction between membrane lectins and sugar-bearing membrane molecules is responsible for the binding (homing) of stem cells to stroma. Agglutination studies locate these lectins, designated as homing receptors, to the membrane of CFU-S. Thus, homing receptors for hemopoietic stem cells are lectins with galactosyl and mannosyl specificities.
authors.affiliation: Veterans Administration Hospital, Jackson, MS.
authors.forename: M
authors.initials: M
authors.lastname: Tavassoli
authors.forename: S
authors.initials: S
authors.lastname: Aizawa
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules; D002454:Cell Differentiation; D002478:Cells, Cultured; D005643:Fucose / Q000494:pharmacology; D005690:Galactose / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D037102:Lectins / Q000378:metabolism*; D008358:Mannose / Q000494:pharmacology*; D008562:Membrane Glycoproteins / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D012710:Serum Albumin, Bovine
chemical_list: D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D037102:Lectins; D008562:Membrane Glycoproteins; D012710:Serum Albumin, Bovine; D005643:Fucose; D008358:Mannose; D005690:Galactose