Radioimmunoassay typing gives a more precise definition of the HLA association of type 1 (insulin-dependent) diabetes.
The problem of the HLA association of Type 1 (insulin-dependent) diabetes was re-examined by testing Class II antigenic specificities detectable by radioimmunoassay. Established (DRw53, DQw1, DQw2, DQw3) as well as newly described (DC5, DCalpha3) specificities were typed. The data obtained suggest that the association with DR3 and DR4 is secondary to that with DQ specificities in linkage disequilibrium with DR3 and DR4.
Tosi
R
R
Vela
M
M
Adorno
D
D
Longo
A
A
Papola
F
F
Maccarone
D
D
Centis
D
D
Tanigaki
N
N
Raponi
M P
MP
Candela
A
A
D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D005260:Female; D005838:Genotype; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis* / Q000235:genetics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011863:Radioimmunoassay
D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II