title: Pharmacokinetics of a single oral dose of ofloxacin in patients with renal failure.
abstract: Ten male patients with chronic renal failure and five healthy male volunteers were given a single oral dose of ofloxacin (200 mg). Serum concentrations of ofloxacin were determined by a microbiological assay. The pharmacokinetic parameters were obtained using an open one-compartment model. The study showed prolonged half-life and decreased elimination of ofloxacin in patients with renal failure. The median t1/2 of ofloxacin was prolonged in patients (38.5 h) compared with volunteers (17.8 h) (P less than 0.01). The median AUC0----infinity was increased in patients (58.45 micrograms/ml X h) compared to volunteers (17.34 micrograms/ml X h) (P less than 0.01). Also, the median Cl was decreased in patients (3.42 l/h) compared with volunteers (11.53 l/h) (P less than 0.01).
authors.forename: S
authors.initials: S
authors.lastname: Nawishy
authors.forename: I
authors.initials: I
authors.lastname: Moukhtar
authors.forename: M
authors.initials: M
authors.lastname: Sabbour
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin; D010078:Oxazines / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin