Effects of serotonergic and anticholinergic drugs in haloperidol-induced dystonia in Cebus monkeys.
In rodents, serotonin (5-HT) antagonists counteract behavioral and biochemical effects of neuroleptic drugs. Therefore, we have studied the effect of different 5-HT drugs and one anticholinergic drug in acute dystonia in five cebus monkeys chronically treated with haloperidol. Acute dystonia induced by subcutaneous injections of haloperidol was slightly reduced by the 5-HT antagonist methysergide (4.0 mg/kg), while mianserin, ketanserin, and ritanserin (R 55 667; a new selective and potent 5-HT receptor blocker) had no effect. This was contrasted by the marked antidystonic effect of the anticholinergic drug biperiden (0.05-1.0 mg/kg). The 5-HT agonist citalopram, a specific 5-HT uptake inhibitor, had no significant effect. It is concluded that 5-HT antagonists have no useful effect in neuroleptic-induced dystonia.
Povlsen
U J
UJ
Noring
U
U
Laursen
A L
AL
Korsgaard
S
S
Gerlach
J
J
D000818:Animals; D001712:Biperiden / Q000627:therapeutic use; D002428:Cebus; D015283:Citalopram; D004305:Dose-Response Relationship, Drug; D004421:Dystonia / Q000139:chemically induced / Q000503:physiopathology*; D006220:Haloperidol / Q000633:toxicity*; D008297:Male; D008784:Methysergide / Q000627:therapeutic use; D008803:Mianserin / Q000627:therapeutic use; D010276:Parasympatholytics / Q000627:therapeutic use*; D011437:Propylamines / Q000627:therapeutic use; D012702:Serotonin Antagonists / Q000627:therapeutic use*
D010276:Parasympatholytics; D011437:Propylamines; D012702:Serotonin Antagonists; D015283:Citalopram; D001712:Biperiden; D008803:Mianserin; D006220:Haloperidol; D008784:Methysergide