Hypolipemic and potential antiatherosclerotic properties of diprophyllinyl-4-benzyloxybenzoate.
To assess the hypolipemic and antiatherosclerotic activity of diprophyllinyl-4-benzyloxybenzoate guinea-pigs were kept on a high-lipid diet alone or with the tested compound for 21 days, and rabbits--for 3 months. It was found that diprophyllinyl-4-benzyloxybenzoate displays a distinct hypolipemic activity, particularly with respect to cholesterol, both in guinea-pigs and rabbits. It also depresses the cholesterol and the trigliceride content in liver homogenates and shows a tendency to normalize the low-density-lipoprotein fraction in guinea-pigs, as well as cholesterol of the high-density lipoprotein fraction, and malon dialdehyde in rabbits. The area of intima covered with atheromatous plaques was smaller in rabbits receiving the high-lipid diet with diprophyllinyl-4-benzyloxybenzoate than in those receiving that diet alone.
Wójcicki
J
J
Institute of Pharmacology and Toxicology, Medical Academy, Szczecin, Poland.
Samochowiec
L
L
Dadej
R
R
Jaworska
M
M
Gawrońska-Szklarz
B
B
Kownacka
A
A
Ryshenkov
V
V
Chistyakova
A
A
Acsenova
N
N
D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000378:metabolism; D002499:Centrifugation, Density Gradient; D002784:Cholesterol / Q000097:blood; D004400:Dyphylline / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006168:Guinea Pigs; D000960:Hypolipidemic Agents; D008055:Lipids / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D011817:Rabbits; D013806:Theophylline / Q000031:analogs & derivatives*; D014280:Triglycerides / Q000097:blood
D000960:Hypolipidemic Agents; D008055:Lipids; D014280:Triglycerides; C055922:diprophyllinyl-4-benzyloxybenzoate; D004400:Dyphylline; D008315:Malondialdehyde; D002784:Cholesterol; D013806:Theophylline