Genetic basis for Ia positivity and susceptibility to lactic dehydrogenase virus in macrophages of SJL/J mice.
SJL/J mice showed a higher elevation of serum lactic dehydrogenase after lactic dehydrogenase virus (LDV) infection, and a higher per cent of Ia positive and LDV infectable cultured macrophages, than several other mouse strains. Genetic studies suggested that these unique characteristics in SJL/J mice are closely linked and inherited as a single autosomal recessive trait, which is not within the H-2 gene complex.
Inada
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Mims
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D000818:Animals; D004198:Disease Susceptibility; D005260:Female; D006183:H-2 Antigens / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D007772:Lactate dehydrogenase-elevating virus / Q000302:isolation & purification*; D008264:Macrophages / Q000276:immunology / Q000382:microbiology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D012376:Rodent Diseases / Q000235:genetics* / Q000276:immunology; D013045:Species Specificity; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology / Q000662:veterinary*
D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II