title: Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein.
abstract: The primary structure of human uromodulin, a 616-amino acid, 85-kilodalton glycoprotein with in vitro immunosuppressive properties, was determined through isolation and characterization of complementary DNA and genomic clones. The amino acid sequence encoded by one of the exons of the uromodulin gene has homology to the low-density-lipoprotein receptor and the epidermal growth factor precursor. Northern hybridization analyses demonstrate that uromodulin is synthesized by the kidney. Evidence is provided that uromodulin is identical to the previously characterized Tamm-Horsfall glycoprotein, the most abundant protein in normal human urine.
authors.forename: D
authors.initials: D
authors.lastname: Pennica
authors.forename: W J
authors.initials: WJ
authors.lastname: Kohr
authors.forename: W J
authors.initials: WJ
authors.lastname: Kuang
authors.forename: D
authors.initials: D
authors.lastname: Glaister
authors.forename: B B
authors.initials: BB
authors.lastname: Aggarwal
authors.forename: E Y
authors.initials: EY
authors.lastname: Chen
authors.forename: D V
authors.initials: DV
authors.lastname: Goeddel
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D001483:Base Sequence; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003001:Cloning, Molecular; D003545:Cysteine; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation; D005796:Genes; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D009088:Mucoproteins / Q000032:analysis* / Q000235:genetics*; D010446:Peptide Fragments / Q000032:analysis; D012333:RNA, Messenger / Q000235:genetics; D058949:Uromodulin
chemical_list: D000596:Amino Acids; D006023:Glycoproteins; D009088:Mucoproteins; D010446:Peptide Fragments; D012333:RNA, Messenger; C548612:UMOD protein, human; D058949:Uromodulin; D004247:DNA; D003545:Cysteine