Prostaglandin F2-alpha bladder irrigation for control of intractable cyclophosphamide-induced hemorrhagic cystitis.
We report a case of intractable cyclophosphamide-induced hemorrhagic cystitis. Conservative therapy, including suprapubic cystostomy with through-and-through bladder irrigation, failed to slow the bleeding. We then instilled 200 cc of a 0.7 mg. per cent solution of prostaglandin F2-alpha into the bladder for 4 hours daily. The bleeding ceased completely by the end of treatment 5 and the patient remains free of hematuria. There were no side effects noted during the 5 days of treatment. This form of therapy offers an effective, safe and easy alternative to more caustic bladder irrigants and methods of treatment.
Shurafa
M
M
Shumaker
E
E
Cronin
S
S
D000283:Administration, Intravesical; D003449:Cryoglobulinemia / Q000188:drug therapy; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000627:therapeutic use; D003556:Cystitis / Q000139:chemically induced* / Q000188:drug therapy; D015237:Dinoprost; D006801:Humans; D008297:Male; D008875:Middle Aged; D011460:Prostaglandins F / Q000008:administration & dosage / Q000627:therapeutic use*; D007507:Therapeutic Irrigation
D011460:Prostaglandins F; D003520:Cyclophosphamide; D015237:Dinoprost