[Structure of the interphase chromatin in the peripheral blood cells of children with acute lympholeukemia and in their healthy parents].
It has been shown using labelled modified AO cytofluorometry of DNP cellular thermal denaturation that the melting profiles of peripheral blood cellular chromatin in children with acute lympholeukemia (ALL) were of strictly individual, "unclassifiable" nature and were similar to those of their mothers but different from those of their fathers and healthy people, which seems in favour of a possible connection between the disease under study and the peculiarities of the mother's genotype. Similar types of deviations have been found in the structure of interphase chromatin of healthy parents of children with ALL. Such a combination of changes in the parents' genotype may prove unfavourable, increasing the birth rate of neonates with a genetic predisposition to the disease in question.
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D000165:Acridine Orange; D000328:Adult; D001773:Blood Cells / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D002843:Chromatin / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D005838:Genotype; D006801:Humans; D007223:Infant; D007399:Interphase; D007945:Leukemia, Lymphoid / Q000097:blood* / Q000235:genetics; D008297:Male
D002843:Chromatin; D000165:Acridine Orange
Struktura interfaznogo khromatina kletok perfericheskoĭ krovi u deteĭ s ostrym limfoleĭkozom i u ikh zdorovykh roditeleĭ.