Elective whole-lung irradiation in osteosarcoma treatment: appearance of bilateral breast cancer in two long-term survivors.
The effect of "prophylactic" lung radiation in preventing pulmonary metastasis was studied in a subset of patients with osteosarcoma. Benefit was not noted. Thirteen of the irradiated patients in the treatment group were females; in 2 of the 13, bilateral breast cancer developed approximately 15 years later. Radiation administered to the breast of an adolescent female carries a considerable risk of causing breast cancer.
Ivins
J C
JC
Taylor
W F
WF
Wold
L E
LE
D000293:Adolescent; D001859:Bone Neoplasms / Q000532:radiotherapy*; D001943:Breast Neoplasms / Q000209:etiology*; D002648:Child; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary*; D009378:Neoplasms, Multiple Primary / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D012516:Osteosarcoma / Q000532:radiotherapy*