title: [Genetics and evolution of the Lpm-system in American mink. VI. Identification, genetic control and phylogenesis of the new allotype Lpm13].
abstract: Data on immuno- and biochemical identification, genetic control and phylogenesis of new allotype Lpm13 of the Lpm system in domestic mink are presented. This allotype is encountered in mink populations with the frequency 0.9 and higher. The availability of Lpm13 genetic marker permitted another haplotype to be revealed, in addition to the eight known Lpm haplotypes by means of genetic analysis. It was established that, alongside with the earlier described haplotype Lpm3,4,6,8,9,10,11 (abbreviation H3), there exists a similar haplotype, Lpm3,4,6,8,9,10,11,13 (abbreviation H3.13), containing the Lpm13 gene. Of the rest seven haplotypes, five have the Lpm13 gene and two do not. Taking into account this gene and corresponding antigenic marker, the differentiation of 28, instead of 25, phenotypes and 45, instead of 36, genotypes for the Lpm system became possible. Lpm13 antigenic specificity was found with no exception in all individual serum samples taken from ten species and interspecific hybrids of Mustelidae which are closely related to domestic mink. The data obtained give grounds to refer the newly identified Lpm13 gene to the first evolutionary conservative category of genes of the multigenic Lpm system which is also represented by the Lpm6, Lpm9, Lpm10 and Lpm11 genes. The hypotheses of instantaneous formation of polymorphism of the Lpm system in domestic mink are briefly regarded.
authors.forename: O K
authors.initials: OK
authors.lastname: Baranov
authors.forename: T V
authors.initials: TV
authors.lastname: Kutiavina
authors.forename: V I
authors.initials: VI
authors.lastname: Ermolaev
authors.forename: M A
authors.initials: MA
authors.lastname: Savina
authors.forename: D K
authors.initials: DK
authors.lastname: Beliaev
mesh_terms: D000818:Animals; D005819:Genetic Markers; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D008907:Mink / Q000235:genetics*; D005810:Multigene Family; D010641:Phenotype; D010802:Phylogeny
chemical_list: D005819:Genetic Markers; D007126:Immunoglobulin Allotypes
vernacular_title: Genetika i évoliutsiia Lpm-sistemy amerikanskoĭ norki. Soobshchenie VI. Identifikatsiia, geneticheskiĭ kontrol' i filogenez novogo allotipa Lpm13.