title: Antiviral effects of dihydroxypropyladenine [RS)-DHPA) and bromovinyldeoxyuridine (BVDU) on plant viruses.
abstract: Two established antiviral agents, dihydroxypropyladenine (RS)-DHPA and bromovinyldeoxyuridine (BVDU) were evaluated for their inhibitory effects on 4 plant viruses: Tobacco mosaic virus, potato virus X (PVX), eggplant mosaic virus (EMV) and a potyvirus isolated from Solanum palinacanthum (Poty-Sp). Using the leaf disc incubation test, BVDU proved virtually inactive while (RS)-DHPA efficiently inhibited EMV and Poty-Sp when applied at concentrations as low as 5 mg/l. TMV was less susceptible to the chemical while PVX could be inhibited at drug concentrations of 100 mg/l. To achieve a similar inhibitory effect in the leaf spray test, concentrations up to 250 and 500 mg/l were required. Using these tests no phytotoxicity was observed with (RS)-DHPA at any of the concentrations used.
authors.affiliation: Instituto Biológico, Seção de Virologia Vegetal, São Paulo, Brazil.
authors.forename: G
authors.initials: G
authors.lastname: De Fazio
authors.forename: M
authors.initials: M
authors.lastname: Vicente
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D000998:Antiviral Agents; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D009029:Mosaic Viruses / Q000187:drug effects; D010942:Plant Viruses / Q000187:drug effects*; D010944:Plants / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; C020235:brivudine; C016391:9-(2,3-dihydroxypropyl)adenine; D001973:Bromodeoxyuridine; D000225:Adenine