[Prospective EEG studies of offspring of fathers with epilepsy].
EEG tracings were analysed in 100 children of 58 fathers with epilepsy. A group of children aged up to 18 years was isolated and in 40 of them serial EEG investigations were carried out during 4-5 years. In this group abnormal tracings were found in 51% of cases, with seizure activity in 31%. In five children (5%) epilepsy was diagnosed. Seizure activity was significantly more frequent in girls than in boys (42.8% vs 19.6%). Seizure activity occurred with similar frequency in children born before or after manifestation of the disease in the father (30.1% and 31.9%). The observation of evolution of seizure activity during 4-5 years suggests that the greatest penetration is at the age of 4-7 years (52.6%) and then it decreases gradually. Non-seizure pathological activity with features of bioelectric immaturity was observed most frequently in the youngest children aged 1-3 years, especially in boys. The evolution of these changes was bidirectional: in most cases the tracings became normal within 4-5 years, in a lower number of cases seizure activity appeared.
Majchrzak
R
R
II Katedry i Kliniki Neurologii Sl. AM w Zabrzu.
Grudzińska
B
B
Pierzchała
K
K
D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D005220:Fathers; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies
Prospektywne badania EEG u potomstwa ojców chorych na padaczke.