Effect of temperature on the cutaneous phototoxic reaction to 8-methoxypsoralen in human skin.
Phototoxic erythema in human skin resulting from topical 8-methoxypsoralen (8-MOP) + UVA exposure was examined at different skin temperatures. Increased skin temperature resulting from radiant or conductive heating during UVA exposure decreased the ensuing phototoxic response. Preheating the skin for 30 min prior to UVA exposure caused a greater decrease in phototoxicity.
Youn
J I
JI
Wellman Laboratory, Massachusetts General Hospital, Boston.
Maytum
D
D
Gange
R W
RW
D000328:Adult; D003080:Cold Temperature; D004890:Erythema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006361:Heating / Q000379:methods; D006358:Hot Temperature; D006801:Humans; D008297:Male; D011701:PUVA Therapy / Q000009:adverse effects*; D010787:Photosensitivity Disorders / Q000139:chemically induced / Q000517:prevention & control*