title: Immediate and delayed effects of cis-platinum treatment on the short term biodistribution of 67Ga-citrate in mice.
abstract: The co-administration of a single medium toxic dose (5 mg/kg) of the chemotherapeutic drug cis-platinum (cis-Pt) with 67Ga-citrate was found to have minimal effects on the 3 h tissue distribution of the radiopharmaceutical in mice. When the same drug dose was given at two day intervals preceding the co-administered dose, virtually all tissues accumulated 67Ga to a greater extent. The tissue distribution of radiolabeled cis-Pt supported the development of drug-induced renal dysfunction as the primary cause.
authors.forename: T R
authors.initials: TR
authors.lastname: Sykes
authors.forename: A A
authors.initials: AA
authors.lastname: Noujaim
authors.forename: L G
authors.initials: LG
authors.lastname: Stephens-Newsham
authors.forename: B C
authors.initials: BC
authors.lastname: Lentle
authors.forename: A R
authors.initials: AR
authors.lastname: Turner
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000378:metabolism / Q000494:pharmacology*; D005710:Gallium Radioisotopes / Q000378:metabolism*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D005710:Gallium Radioisotopes; D002945:Cisplatin