title: Present experiences with omeprazole in the Zollinger-Ellison syndrome.
abstract: As effective tumour resection can be achieved in only a minority of patients with Zollinger-Ellison syndrome, therapy in such patients is usually directed to treatment and prevention of symptoms induced by hypersecretion of gastric acid. Omeprazole is a potent and long-acting inhibitor of pentagastrin stimulated gastric acid secretion in normal subjects, and this prompted a study of the effect of omeprazole on gastric acid hypersecretion and acid peptic disease resulting from endogenous hypergastrinaemia in Zollinger-Ellison patients. Omeprazole was found to be effective even in those patients whose symptoms were not adequately controlled by high doses of histamine H2-receptor antagonists, with or without pirenzepine. Serum gastrin levels were not affected; no laboratory abnormalities and minimal side-effects induced by omeprazole have been reported in Zollinger-Ellison patients even on long-term studies of up to 27 months.
authors.forename: C B
authors.initials: CB
authors.lastname: Lamers
mesh_terms: D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D006801:Humans; D009853:Omeprazole; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy*
chemical_list: D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D005755:Gastrins; D009853:Omeprazole