The biodistribution of 67Ga-labelled N-hydroxyamino acid derivatives in tumour-bearing rats.
The biodistribution of 67Ga-labelled complexes of some mono- and di-N-hydroxyamino acid derivatives and of two siderophores (trihydroxamates) were evaluated in Rhabdomyosarcoma-bearing rats. It was found that the mono- and dihydroxamates could not enhance the tumour-localizing properties of 67Ga-citrate, while the 67Ga-labelled trihydroxamates showed very rapid urinary excretion.
Herscheid
J D
JD
Knops
G H
GH
Hoekstra
M
M
D000818:Animals; D002614:Chelating Agents; D003676:Deferoxamine / Q000031:analogs & derivatives; D005291:Ferrichrome / Q000031:analogs & derivatives; D005710:Gallium Radioisotopes; D006877:Hydroxamic Acids; D011877:Radionuclide Imaging; D051381:Rats; D012208:Rhabdomyosarcoma / Q000000981:diagnostic imaging*; D012513:Sarcoma, Experimental / Q000000981:diagnostic imaging; D014018:Tissue Distribution
D002614:Chelating Agents; D005710:Gallium Radioisotopes; D006877:Hydroxamic Acids; D005291:Ferrichrome; C048996:N-desferriferrichrome; C044311:N-succinyldesferrioxamine B; D003676:Deferoxamine