Cytogenetic findings in a large bowel adenocarcinoma.
Cytogenetic analysis of a biopsy specimen taken during sigmoidoscopy from an adenocarcinoma of the large bowel revealed a hypodiploid karyotype with numerical and structural abnormalities identified as trisomy 7, t(3;12), t(1;17), interstitial deletion of the long arm of a chromosome #5 and loss of the Y chromosome with double X chromosomes. The possibility of this karyotype being a further evolutionary step in a subgroup of large bowel cancers and the clinical value of the above findings are discussed.
Ferti-Passantonopoulou
A
A
Panani
A
A
Avgerinos
A
A
Raptis
S
S
D000230:Adenocarcinoma / Q000235:genetics*; D000368:Aged; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D012004:Rectal Neoplasms / Q000235:genetics*; D012811:Sigmoid Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic; D014314:Trisomy
D005819:Genetic Markers