Isolated angiitis of the brain in a young female on the contraceptive pill.
The case of a 15 year old girl with a rapidly progressing right sided hemiparesis is reported. The history and clinical manifestations were suggestive of either herpes simplex encephalitis or occlusion of the left middle cerebral artery. At necropsy an occlusive thrombosis of the left middle cerebral artery due to a segmental necrotizing granulomatous panarteritis was found. The cause was obscure. A plausible incriminating factor was the contraceptive pill.
Nagaratnam
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Department of Medicine, Broken Hill Base Hospital, N.S.W., Australia.
James
W E
WE
D000293:Adolescent; D001167:Arteritis / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D002536:Cerebral Arteries / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000473:pathology; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D004997:Ethinyl Estradiol / Q000009:adverse effects*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D006801:Humans; D009644:Norgestrel / Q000009:adverse effects*
D003278:Contraceptives, Oral, Hormonal; D009644:Norgestrel; D004997:Ethinyl Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination