[Chronic 90-day toxicity of apramycin in chickens].
Investigations were carried out on 72 2-day-old broilers, divided into four groups (one control group--27 broilers and 3 experimental groups--15 broilers in each), treated with apramycin sulphate (AS), which was added to the food in concentration 0, 330, 1000 and 1600 mg/kg (corresponding to 0, 50, 150 and 250 mg/kg m.), in the course of 90 days. It was established that dose of 50 mg/kg m. AS does not causes toxic activities. With doses of 50, 150 and 250 mg/kg m. AS causes reduction of the degree of the pseudo-eosinophilic cells and increase of the percentage of leucocytes--in range similar to the physiological variations, contributes to stimulate the growth and the feed conversion. With doses of 150 and 250 mg/kg m. AS causes reduction of the content of haemoglobin and reduction of the number of erythrocytes; causes dystrophic changes in the internal organs.
Pashov
D
D
Vangelov
S
S
Diakov
L
L
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001773:Blood Cells / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002645:Chickens / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D009328:Nebramycin / Q000031:analogs & derivatives / Q000633:toxicity*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D009328:Nebramycin; C011666:apramycin
Prouchvane vŭrkhu khronichnata 90-dnevna toksichnost na apramitsina pri pileta.