Concentrations of progesterone and oestradiol-17 beta after administration of a 3 beta-hydroxysteroid dehydrogenase inhibitor to sheep in late pregnancy.
An inhibitor of 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) activity was administered to sheep in late pregnancy. A rapid fall in plasma progesterone concentrations followed, associated with premature delivery by all animals 44 +/- 3 h (S.E.M.) after administration of inhibitor. A significant (about twofold) increase in plasma concentrations of oestradiol-17 beta was detected immediately before delivery. These results demonstrate, in contrast to previous reports, that 3 beta-HSD inhibitors have the capacity consistently to induce premature delivery associated with increased oestrogen release in sheep.
Taylor
M J
MJ
D015096:3-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors*; D000737:Androstenols / Q000494:pharmacology*; D000818:Animals; D004958:Estradiol / Q000097:blood*; D005260:Female; D007752:Obstetric Labor, Premature / Q000097:blood*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*; D012756:Sheep
D000737:Androstenols; D011374:Progesterone; D004958:Estradiol; C046855:epostane; D015096:3-Hydroxysteroid Dehydrogenases