Clinical methods in psychiatric genetics. I. Robustness of genetic marker investigative strategies.
Population stratification, secondary effects of illness or treatment, biological heterogeneity of a clinical syndrome, or complex biology underlying a syndrome (where only one component is measured) are conditions which may obscure the association of a genetic risk factor with a clinical syndrome. We consider several investigative strategies under each of these conditions. Only segregation-based paradigms are robust to genetic heterogeneity and population stratification. But secondary effects on the risk factor produced by illness or treatment require other strategies for their detection.
Gershon
E S
ES
Goldin
L R
LR
D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D004200:Diseases in Twins; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D010375:Pedigree; D012306:Risk
D005819:Genetic Markers