title: Staphylococcus aureus infection as a complication of isotretinoin therapy.
abstract: Eighteen patients developed Staphylococcus aureus infection during or shortly after a five-month course of therapy with isotretinoin. Staphylococcus aureus was recovered both from lesions and from the anterior nares. In a prospective study, 4% of control patients treated with isotretinoin alone developed S aureus infection, while none who applied topical antibiotic to the anterior nares developed infection. Control patients had a 64% prevalence of anterior nares colonization with S aureus, compared with 18% in the topical antibiotic group.
authors.forename: J J
authors.initials: JJ
authors.lastname: Leyden
authors.forename: W D
authors.initials: WD
authors.lastname: James
mesh_terms: D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003872:Dermatitis / Q000209:etiology*; D006801:Humans; D015474:Isotretinoin; D009824:Ointments; D013203:Staphylococcal Infections / Q000139:chemically induced* / Q000517:prevention & control; D013211:Staphylococcus aureus; D014212:Tretinoin / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D009824:Ointments; D014212:Tretinoin; D015474:Isotretinoin