[Pattern of distribution of apolipoproteins A and B in the lipoprotein fractions of serum in pregnant patients and post partum].
Investigating the for gestationally caused changes and their restitution p. partum we determined in 104 women without metabolic disorders the apolipoproteins A and B respectively in serum, in the main lipoprotein fractions VLDL, IDL, LDL, HDL and in the "rest protein" remaining after separation of the lipoproteins from the serum. In gestation there is an increase in the serum level of apo A of about 30% (p less than 0.001) reaching its maximum in the middle period of pregnancy. The post partal restitution of these changes takes more than 5 weeks happening faster at primarily delactated women. Gestational changes concerning apo A are only caused by a 30% higher concentration of apo A in HDL (p less than 0.001). The serum level of apo B seems to increase continuously meanwhile gestation reaching its maximum from about 60% (p less than 0.001) at the term. The restitution of the gestational changes concerning apo B also requires more than 5 weeks showing no dependence from lactation. The changes of serum apo B are quantitatively most influenced by the 45% higher concentration of apo B in LDL (p less than 0.001), despite the marked changes of apo B in relation to the nonpregnant comparative group found in VLDL and IDL respectively with either 270% (each p less than 0.001). Hyperbetalipoproteinemia in pregnancy was proved in 32%, but in no case the ratio apo B/apo A showed pathological values, because of also raised levels of apo A in these women. By this astonishing phenomenon the gestational hyperlipoproteinemia is characterized as an autonomic metabolic situation, which represents no earlier described type according to the Fredrickson classification.(ABSTRACT TRUNCATED AT 250 WORDS)
Steitz
H O
HO
Klinik und Poliklinik für Geburtshilfe und Frauenkrankheiten, Johannes Gutenberg-Universität Mainz.
Brockerhoff
P
P
Holzer
A
A
Schicketanz
K H
KH
Stinner
B
B
Rathgen
G H
GH
D000293:Adolescent; D000328:Adult; D001054:Apolipoproteins A / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D001942:Breast Feeding; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011644:Puerperal Disorders / Q000097:blood*
D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008074:Lipoproteins
Verteilungsmuster von Apolipoprotein A und B in den Lipoproteinfraktionen des Serums bei Schwangeren und post partum.