The effect of metoclopramide on the Ganzfeld electroretinogram.
Antecedent light flashes enhance the amplitude of the electroretinogram (ERG) oscillatory potentials, but do not modify other ERG responses nor dark-adaptation sensory thresholds. Metoclopramide infusion (i.v.) has a generally attenuating effect on the ERG, which is more evident under conditions of dark- than light-adaptation. Metoclopramide decreases the peak amplitude of the rod b-wave and the dark-adapted cone b-wave in a similar manner; it also significantly increases the implicit time of the rod b-wave, but not of the dark-adapted cone b-wave. In addition metoclopramide reverses the enhancement of the oscillatory potentials by the antecedent light flashes.
Jaffe
M J
MJ
National Eye Institute, Bethesda, Md.
Levinson
P D
PD
Zimmlichman
R
R
Coen
J C
JC
Karson
C N
CN
de Monasterio
F M
FM
D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D003623:Dark Adaptation; D004596:Electroretinography; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D010775:Photic Stimulation; D010786:Photoreceptor Cells / Q000187:drug effects / Q000502:physiology; D012160:Retina / Q000502:physiology*
D008787:Metoclopramide