Association of viral hepatitis A with HLA-A9.
HLA-A and B phenotyping was carried out, during a viral hepatitis A (VHA) epidemic in Brazil, on 47 unrelated patients with VHA and 53 unrelated healthy subjects of the same age, sex, social status, and ethnic origin. An increased frequency of HLA-A9 (44.7% vs. 15.1%) and a decrease of that of HLA-A3 (2.1% vs. 22.6%) were observed when compared with controls. After correction for the number of antigens tested, only the positive association with HLA-A9 was observed. It was found that the relative risk for an HLA-A9 carrier to develop VHA was 4.5.
Arce-Gomez
B
B
Moliterno
R A
RA
Rodrigues
A L
AL
Barbosa
J
J
deOliveira
M R
MR
Abreu
J C
JC
SpeckdoNascimento
V A
VA
Sasaki
M G
MG
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006506:Hepatitis A / Q000235:genetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010641:Phenotype
D006680:HLA Antigens; D015234:HLA-A Antigens; C037709:HLA-A9 antigen; D015235:HLA-B Antigens