title: Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion.
abstract: Tumor cells grown in the presence of 1-O-alkyl-2-O-methylglycero-3-phosphocholine (AMG-PC) accumulated this ether lipid in their membranes. Depending on the cell type and the dose of the compound, up to 17% of the total phospholipids of the purified plasma membranes consisted of authentic AMG-PC. Extensive incorporation of the agent resulted in a decrease in plasma membrane fluidity and inhibition of tumor cell invasiveness in embryonic chick heart fragments. The extent of AMG-PC incorporation and fluidity change was not strictly correlated with the degree to which tumor cell invasion was inhibited.
authors.affiliation: Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam.
authors.forename: W J
authors.initials: WJ
authors.lastname: van Blitterswijk
authors.forename: H
authors.initials: H
authors.lastname: Hilkmann
authors.forename: G A
authors.initials: GA
authors.lastname: Storme
mesh_terms: D000818:Animals; D002460:Cell Line; D005995:Glyceryl Ethers / Q000493:pharmacokinetics* / Q000494:pharmacology; D008560:Membrane Fluidity / Q000187:drug effects*; D010742:Phospholipid Ethers / Q000493:pharmacokinetics* / Q000494:pharmacology; D051381:Rats; D013347:Subcellular Fractions / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014410:Tumor Stem Cell Assay
chemical_list: D005995:Glyceryl Ethers; D010742:Phospholipid Ethers