title: Bias of the contribution of single-locus effects to the variance of a quantitative trait.
abstract: Advances in our understanding of the physiology of many quantitative phenotypes combined with better measurement abilities is providing a means for pursuing a measured genotype approach to partitioning the phenotypic variance into the contribution of separate loci. The standard estimate of the contribution of a single locus to the phenotypic variance applied recently in the human genetics literature is a biased statistic. We compare the biased estimates from several published studies with biased corrected estimates to illustrate the general problem.
authors.forename: E
authors.initials: E
authors.lastname: Boerwinkle
authors.forename: C F
authors.initials: CF
authors.lastname: Sing
mesh_terms: D005819:Genetic Markers; D014644:Genetic Variation; D005826:Genetics, Medical; D006801:Humans; D010641:Phenotype; D011336:Probability
chemical_list: D005819:Genetic Markers