Metabolism of 24-ethyl-4-cholesten-3-one and 24-ethyl-5-cholesten-3 beta-ol (sitosterol) after intraperitoneal injection in the rat.
14C-labeled C29- and C27-steroids were injected in rats, which were killed after 14 days. Phytosterols (C29) were excreted mainly as such, whereas C27-steroids were recovered essentially as water soluble metabolites. The total 14C-excretion was lower from 3-oxo, delta 4-steroids (5 alpha-stanol precursors) than from 3 beta-hydroxy,delta 5-steroids. 14C-Phytosterols were accumulated more than C27-steroids in liver, serum (mainly in HDL) and especially in adrenal glands and ovaries. In relation to serum, particularly the 5 alpha-stanols were enriched in the adrenal glands and ovaries. No striking lysosomal accumulation of any of the steroids was found.
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D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology; D001798:Blood Proteins / Q000378:metabolism; D006224:Cricetinae; D005260:Female; D007274:Injections, Intraperitoneal; D008052:Lipid Metabolism, Inborn Errors / Q000150:complications / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012855:Sitosterols / Q000008:administration & dosage / Q000378:metabolism*; D013347:Subcellular Fractions / Q000378:metabolism; D014018:Tissue Distribution
D001798:Blood Proteins; D012855:Sitosterols; C025473:gamma-sitosterol; C052740:24-ethyl-4-cholesten-3-one