[Five cases of Parkinson disease with the past history of hand injury].
Incidental occurrence of Parkinson disease following to the history of peripheral trauma was reported in 1932 by Naville and Morsier. So far as we know not more than 50 cases with such an interesting outbreaks have been reported. In Japan no report has been published. We happened to have opportunities to observe five cases of Parkinson disease with similar past history of peripheral trauma comprising two males and three females. Their age at onset ranged from 40 to 74 years and all the five cases had histories of finger injury, including amputation in four cases, followed by insidious onset of tremulous movement at the same site of the trauma during the period between two months and 36 years. So far as we know, no evident explanation is made concerning to the etiological interrelation between onset of Parkinson disease and trauma of the fingers. It appears to be suggestive of the possible mechanism, in which chronic persistent facilitation from the site of trauma up to the diencephalospinal dopamine system, recently advocated by Lindvall and others, result in Parkinson disease beginning at the homolateral site of the previous peripheral trauma.
Katsui
Y
Y
First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
Takahashi
A
A
Takezawa
H
H
D000328:Adult; D000368:Aged; D004027:Diencephalon / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005260:Female; D005383:Finger Injuries / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D013116:Spinal Cord / Q000378:metabolism
D004298:Dopamine