title: Cytogenetic studies in twelve patients with primary myelofibrosis and myeloid metaplasia.
abstract: Chromosome studies on bone marrow and/or peripheral blood cells without phytohemagglutinin were performed on 12 patients with primary myelofibrosis with myeloid meta-plasia (PMMM) between 1980 and 1984. Abnormal clones were found in six patients (50%). In five cases the abnormal clone involved the long arm of chromosome #7, two of which also had partial trisomy of chromosome #1 and trisomy of 9. Additional abnormalities involving chromosomes #3, #5, #11, #13, #15, and #21 were each found once. Review of the literature showed few studies on the cytogenetics of PMMM. No specific chromosomal pattern can be established; however, abnormalities described are nonrandom.
authors.forename: N
authors.initials: N
authors.lastname: Smadja
authors.forename: M
authors.initials: M
authors.lastname: Krulik
authors.forename: A
authors.initials: A
authors.lastname: de Gramont
authors.forename: A
authors.initials: A
authors.lastname: Sirinelli
authors.forename: P
authors.initials: P
authors.lastname: Brissaud
authors.forename: C
authors.initials: C
authors.lastname: Dray
authors.forename: A A
authors.initials: AA
authors.lastname: Audebert
authors.forename: J
authors.initials: J
authors.lastname: Debray
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000235:genetics*
chemical_list: D005819:Genetic Markers