Medical and drug risk factors associated with neuroblastoma: a case-control study.
A matched case-control study of prenatal risk factors for neuroblastoma was conducted, including 104 cases diagnosed over the period 1970-79 in the Greater Delaware Valley. Significantly elevated odds ratios (ORs) were associated with maternal use of a neurally active drug during pregnancy (OR = 2.83), sex hormone exposure 3 months prior to or during pregnancy (OR = 2.25), frequent alcohol consumption during pregnancy (OR = 9.0), and maternal use of diuretic drugs during pregnancy (OR = 5.75). Significantly more case mothers than control mothers reported use of hair coloring products during pregnancy (OR = 3.0). No association was found between cigarette smoking, coffee consumption, or medical irradiation and case-control status.
Kramer
S
S
Ward
E
E
Meadows
A T
AT
Malone
K E
KE
D000428:Alcohol Drinking; D000932:Antiemetics / Q000009:adverse effects; D003069:Coffee / Q000009:adverse effects; D004232:Diuretics / Q000009:adverse effects; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000528:radiation effects; D012739:Gonadal Steroid Hormones / Q000009:adverse effects; D006202:Hair Dyes / Q000009:adverse effects; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000209:etiology* / Q000235:genetics; D010634:Phenobarbital / Q000009:adverse effects; D011247:Pregnancy; D012306:Risk; D012907:Smoking
D000932:Antiemetics; D003069:Coffee; D004232:Diuretics; D012739:Gonadal Steroid Hormones; D006202:Hair Dyes; D010634:Phenobarbital