title: New variant translocation (1;8;21) in a case of acute myeloblastic leukemia (M2).
abstract: A new translocation involving chromosome #1, #8, and #21 in a patient with type M2 acute myeloblastic leukemia is reported. The breakpoint of #1 in this case was at band p13 and differed from that in two previously reported cases of t(1;8;21) involving the long arm of #1. A key event leading to the development of the M2 phenotype appears to be a break at band q22 of #8 with associated translocation of the terminal end of the long arm of #21.
authors.forename: H
authors.initials: H
authors.lastname: Taguchi
authors.forename: T
authors.initials: T
authors.lastname: Kitagawa
authors.forename: M
authors.initials: M
authors.lastname: Yamashita
authors.forename: I
authors.initials: I
authors.lastname: Kubonishi
authors.forename: I
authors.initials: I
authors.lastname: Miyoshi
mesh_terms: D000328:Adult; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic
chemical_list: D005819:Genetic Markers