Retinoids.
Retinoids are vitamin A derivatives that have therapeutic benefit in the treatment of hyperkeratotic genodermatosis, psoriasis, and acne. Isotretinoin (Accutane), a first-generation retinoid, is used in the treatment of cystic acne. Etretinate (Tegison), a second-generation retinoid, is used in the treatment of severe psoriasis. Third-generation drugs are currently being tested. Side effects and long-term toxicity are of concern. Etretinate in combination with ultraviolet B and psoralen-ultraviolet A (PUVA) is especially beneficial in the treatment of psoriasis.
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D005050:Etretinate / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D015474:Isotretinoin; D012176:Retinoids / Q000009:adverse effects / Q000138:chemical synthesis / Q000627:therapeutic use; D012871:Skin Diseases / Q000188:drug therapy; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use
D012176:Retinoids; D014212:Tretinoin; D005050:Etretinate; D015474:Isotretinoin