Microbial transformation of azacarbazoles. I. N-methylation of alpha-, beta-, and gamma-carbolines by Kitasatosporia setae strain.
Microbial transformation of selected azacarbazoles, compounds noted for their activity as antitumor agents, conducted with Kitasatosporia setae strain resulted in N-methylation of pyridine nucleus of alpha-, beta- and gamma-carboline molecule. Formed quaternized intermediates were converted in alkaline conditions into corresponding iso-carbolines. The structure of the final products, alpha-, beta- and gamma-iso-carbolines have been established on the basis of spectral data and confirmed by chemical synthesis.
Peczyńska-Czoch
W
W
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Mordarski
M
M
Kaczmarek
L
L
Nantka-Namirski
P
P
D000192:Actinomycetales / Q000378:metabolism*; D001711:Biotransformation; D002243:Carbolines / Q000493:pharmacokinetics*; D055598:Chemical Phenomena; D002621:Chemistry; D008745:Methylation
D002243:Carbolines; C055572:gamma-carboline; C055571:alpha-carboline