A new leader exon identified in the rat insulin-like growth factor II gene.
In the rat insulin-like growth factor II gene, we identified an alternative 5'-untranslated sequence, in addition to the two sequences documented recently (1986) J. Mol. Biol. 192. 737-752, (1986) J. Biol. Chem. 261. 17138-17149. This sequence was encoded in an extreme 5' separate exon (E1 exon), the promoter region of which could be distinguished from others by features including lack of the TATA-box and GC-repeat, and heterogeneity in the transcriptional initiation.
Ueno
T
T
Department of Biochemistry, Kyushu University, Fukuoka, Japan.
Takahashi
K
K
Matsuguchi
T
T
Endo
H
H
Yamamoto
M
M
D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D004247:DNA / Q000378:metabolism; D005091:Exons; D005796:Genes; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D008114:Liver Neoplasms, Experimental; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D051381:Rats; D013002:Somatomedins / Q000235:genetics*
D013002:Somatomedins; D007335:Insulin-Like Growth Factor II; D004247:DNA