Prostaglandin D2 (PGD2) potentiates cholinergic responsiveness in guinea-pig trachea.
PGD2 dose dependently potentiated the parasympathetic-induced contraction in guinea-pig trachea in vitro. This phenomenon was much more evident in ovalbumin-sensitized guinea-pig trachea. Indomethacin pretreatment enhanced the capacity of PGD2 to potentiate cholinergic-induced contraction in normal but not in ovalbumin-sensitized guinea-pig. PGD2 shifted to the left the curve of the exogenous acetylcholine-induced contraction in guinea-pig trachea, indicating a postsynaptic site of action of PGD2. These data suggest a role of PGD2 in the genesis of hyperreactivity of tracheal smooth muscles, particularly in a model of pulmonary anaphylaxis.
Omini
C
C
Brunelli
G
G
Daffonchio
L
L
Mapp
C
C
Fabbri
L
L
Berti
F
F
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D015237:Dinoprost; D004558:Electric Stimulation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects
D011457:Prostaglandins D; D011460:Prostaglandins F; D015237:Dinoprost; D000109:Acetylcholine; D015230:Prostaglandin D2; D007213:Indomethacin