Pefloxacin concentrations in human aqueous humour and lens.
In 20 patients undergoing cataract extraction, we measured pefloxacin concentrations in the eye. After a 1 h infusion of pefloxacin 400 mg iv, the mean pefloxacin concentrations 2, 6, 12 and 24 h post-infusion were 0.75, 1.45, 1.04 and 0.86 mg/l, respectively. The simultaneous mean pefloxacin concentrations in the lens were 0.09, 0.20, 0.26 and 0.43 mg/l, respectively. The adequate penetration of pefloxacin into uninfected aqueous humour and lens suggests that this antibiotic may be effective in the treatment of certain bacterial endophthalmic infections.
Salvanet
A
A
Fisch
A
A
Lafaix
C
C
Montay
G
G
Dubayle
P
P
Forestier
F
F
Haroche
G
G
D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000378:metabolism*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007908:Lens, Crystalline / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D015366:Pefloxacin
D015366:Pefloxacin; D009643:Norfloxacin