title: Changes in the hepatic perfusion index during the growth and development of experimental hepatic micrometastases.
abstract: Micrometastases were induced in Fisher rats using an intraportal inoculation of 0.2 ml of 8 x 10(7) Walker carcinosarcoma cells. A control group received normal saline. The hepatic perfusion index (HPI) was measured during the growth and development of micrometastases. The HPI at 4 days (0.51 +/- 0.008) and at 6 days (0.65 +/- 0.16) was significantly raised when compared to controls (0.31 +/- 0.07) and at 2 days after inoculation (0.31 +/- 0.06). Hepatic artery flow did not change throughout the study period. However, portal venous inflow was decreased significantly at 4 and 6 days (0.57 +/- 0.16 and 0.55 +/- 0.11) when compared to controls (0.96 +/- 0.34). These results indicate that the change in the hepatic perfusion index is related to a decrease in portal venous inflow. The decrease in portal venous inflow could be a mechanical effect of the micrometastases on intrahepatic blood flow or to increased arteriovenous shunting.
authors.affiliation: University Department of Surgery, Royal Liverpool Hospital, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Nott
authors.forename: J S
authors.initials: JS
authors.lastname: Grime
authors.forename: J
authors.initials: J
authors.lastname: Yates
authors.forename: D W
authors.initials: DW
authors.lastname: Day
authors.forename: J N
authors.initials: JN
authors.lastname: Baxter
authors.forename: S A
authors.initials: SA
authors.lastname: Jenkins
authors.forename: T G
authors.initials: TG
authors.lastname: Cooke
mesh_terms: D000818:Animals; D002279:Carcinoma 256, Walker / Q000000981:diagnostic imaging / Q000556:secondary*; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D008297:Male; D009368:Neoplasm Transplantation; D010477:Perfusion; D011877:Radionuclide Imaging; D051381:Rats; D011916:Rats, Inbred F344; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D013671:Technetium Tc 99m Sulfur Colloid