title: Osteoclast-rich osteosarcoma.
abstract: Nine cases of primary osteoclast-rich osteosarcoma, an undifferentiated sarcoma with an overabundance of osteoclasts and a paucity of tumour osteoid, are reported. They comprise about 3% of all primary osteosarcomas and are histologically related to telangiectatic osteosarcoma, another undifferentiated tumour with abundant osteoclasts and scanty osteoid, perhaps being a predominantly solid variant of the latter. Many of the classical radiological features of an osteosarcoma are absent in these cases and differentiation from a benign lesion is sometimes difficult. Typically, an ill-defined margin surrounds a predominantly lytic lesion of the diaphysis or metaphysis of the femur or tibia of a young patient. A soft-tissue mass is not usually present and periosteal reaction is scanty.
authors.forename: N
authors.initials: N
authors.lastname: Bathurst
authors.forename: N
authors.initials: N
authors.lastname: Sanerkin
authors.forename: I
authors.initials: I
authors.lastname: Watt
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002648:Child; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D010010:Osteoclasts / Q000473:pathology*; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D013977:Tibia / Q000000981:diagnostic imaging