Effect of cis-platinum on the protein binding and pharmacokinetics of 67Ga-citrate.
Cis-platinum, a widely used chemotherapeutic drug, and K2PtCl4, a related complex, were found to inhibit the in vitro protein binding of 67Ga to human transferrin in isolated solution but not to whole serum. Cis-platinum treatment of rabbits resulted in enhanced protein binding and delayed blood clearance of subsequently injected 67Ga-citrate. These effects are related to the toxicity of the drug in vivo.
Sykes
T R
TR
Noujaim
A A
AA
Stephens-Newsham
L G
LG
NG
P K
PK
Lentle
B C
BC
Turner
A R
AR
D000818:Animals; D002945:Cisplatin / Q000494:pharmacology*; D005710:Gallium Radioisotopes / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000097:blood; D007700:Kinetics; D008657:Metabolic Clearance Rate; D011485:Protein Binding; D011817:Rabbits; D014168:Transferrin / Q000378:metabolism*
D005710:Gallium Radioisotopes; D014168:Transferrin; D007501:Iron; D002945:Cisplatin