title: [Intra-arterial infusion of cisplatinum in bone and soft tissue tumors].
abstract: Cisplatin was administered by intravenous injection, intra-arterial injection, and balloon-occluded arterial infusion. The total Pt, ultrafiltrated Pt, and free Pt levels were measured. Intra-arterial injection, in which ultra-filtrated Pt level on the normal side is the same as in intravenous injection, acts to increase the ultrafiltrated Pt level on the affected side. Thus, intra-arterial injection is as effective as preoperative chemotherapy. In two-route chemotherapy, free Pt level on the affected side is extremely high, so for only local control of tumors, two-route chemotherapy is very effective.
authors.forename: S
authors.initials: S
authors.lastname: Matsumoto
authors.forename: N
authors.initials: N
authors.lastname: Kawaguchi
authors.forename: K
authors.initials: K
authors.lastname: Amino
authors.forename: J
authors.initials: J
authors.lastname: Manabe
authors.forename: K
authors.initials: K
authors.lastname: Furuya
authors.forename: Y
authors.initials: Y
authors.lastname: Isobe
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000097:blood / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage* / Q000097:blood; D004285:Dogs; D006801:Humans; D007261:Infusions, Intra-Arterial; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D012516:Osteosarcoma / Q000097:blood / Q000188:drug therapy*; D012512:Sarcoma, Ewing / Q000097:blood / Q000188:drug therapy*; D012983:Soft Tissue Neoplasms / Q000097:blood / Q000188:drug therapy*
chemical_list: D002945:Cisplatin