title: Inhibition of the butyrylcholinesterase by ethidium bromide.
abstract: The effect of ethidium bromide (3,8-diamino-5-ethyl-6-phenyl-phenanthridinium bromide) on the activity of purified horse serum butyrylcholinesterase in vitro has been studied. Ethidium bromide is a middle reversible inhibitor with complex mixed competitive-noncompetitive inhibition kinetics. The inhibitor is bound to the anionic site of the enzyme surface.
authors.affiliation: Purknyĕ Medical Research Institute, Hradec Králové, Czechoslovakia.
authors.forename: J
authors.initials: J
authors.lastname: Patocka
mesh_terms: D000818:Animals; D002091:Butyrylcholinesterase; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002802:Cholinesterases; D004996:Ethidium / Q000494:pharmacology*; D006736:Horses; D007700:Kinetics
chemical_list: D002800:Cholinesterase Inhibitors; D002091:Butyrylcholinesterase; D002802:Cholinesterases; D004996:Ethidium