Imaging fresh venous thrombi in the dog with I-131 and In-111 labeled fibrin-specific monoclonal antibody and F(ab')2 fragments.
The authors report success in imaging thrombi using labeled monoclonal antibody or antibody fragments. An In-111 labeled antibody fragment appears to be the best imaging agent studied to date.
Grossman
Z D
ZD
Department of Radiology (Nuclear Medicine), State University of New York Health Science Center, Syracuse 13210.
Rosebrough
S F
SF
McAfee
J G
JG
Subramanian
G
G
Ritter-Hrncirik
C A
CA
Witanowski
L S
LS
Tillapaugh-Fay
G
G
Urrutia
E
E
D000818:Animals; D000911:Antibodies, Monoclonal; D004285:Dogs; D005337:Fibrin / Q000276:immunology*; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D011877:Radionuclide Imaging; D013924:Thrombophlebitis / Q000000981:diagnostic imaging*
D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D005337:Fibrin