[Rhinocerebral mucormycosis as a complication of cytostatic therapy].
A twelve year old boy with acute lymphoblastic leukemia was treated with combination chemotherapy. Two weeks later a cellulitis of the left upper and lower eyelid appeared, followed by a rapidly increasing, deep necrotic inflammation of the periorbital area leading to proptosis. Mucormycosis was identified by histology and microbiology. The spreading inflammatory process was arrested by amphotericin B in a total dose of 1.2 g combined with a drainage of the necrotic tissue of the paranasal sinus, left orbit and bifrontal cerebral abscess. The patient is still in complete continuous remission four years later but a large defect of the nasal, maxillary and orbital area remains. This case demonstrates that the usual fatal outcome of mucormycosis in leukemia is curable with amphotericin B and aggressive surgery.
Brusis
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T
Rister
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D000666:Amphotericin B / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D005141:Eyelid Diseases / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D008297:Male; D008590:Meningoencephalitis / Q000139:chemically induced* / Q000188:drug therapy; D009091:Mucormycosis / Q000139:chemically induced* / Q000188:drug therapy; D009668:Nose Diseases / Q000139:chemically induced* / Q000188:drug therapy; D009916:Orbital Diseases / Q000139:chemically induced* / Q000188:drug therapy
D000666:Amphotericin B
Rhinocerebrale Mukormykose als Komplikation der Zytostatikatherapie.