Prolactin causes increased turnover of dopamine in 10-day-old rat median eminence.
The present work examines the ability of prolactin to enter the CNS of the rat and effect its feedback stimulation of dopamine release prior to the appearance of prolactin receptors in choroid plexus (i.e., 10 days postnatal). An inhibitor of tyrosine hydroxylase was used to allow the assessment of dopamine turnover separate from synthesis and transport of the amine. Chronic but not acute hyperprolactinemia resulted in increased dopamine release relative to vehicle-treated controls, as shown by diminished fluorescence intensity in the median eminence. These results indicate that activation of the prolactin short-loop feedback system occurs by 10 days postnatal, prior to the appearance of prolactin receptors at the choroid plexus.
Silverman
W F
WF
Department of Anatomy, George Washington University Medical Center, Washington, D.C.
Walsh
R J
RJ
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006966:Hyperprolactinemia / Q000378:metabolism; D008473:Median Eminence / Q000378:metabolism*; D008781:Methyltyrosines / Q000494:pharmacology; D008856:Microscopy, Fluorescence; D011388:Prolactin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D019805:alpha-Methyltyrosine
D008781:Methyltyrosines; D019805:alpha-Methyltyrosine; D011388:Prolactin; D004298:Dopamine