Effects of fluorides on in vitro acid production by dental plaque.
A method that holds human dental plaque on a glass micro-electrode has been used to measure the pH depressions in plaque samples exposed to different concentrations of fluoride from sodium fluoride or sodium monofluorophosphate. Fluoride from both sources gave some inhibition of sucrose-induced acid formation at levels as low as 10 ppm and parallel results at other test concentrations of up to 200 ppm F. Repeated exposures of plaque to fluoride solutions did not interfere with its subsequent ability to ferment sucrose.
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D000143:Acids / Q000378:metabolism; D003773:Dental Plaque / Q000378:metabolism* / Q000503:physiopathology; D005459:Fluorides / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010710:Phosphates / Q000494:pharmacology; D012463:Saliva / Q000502:physiology; D012969:Sodium Fluoride / Q000494:pharmacology; D013395:Sucrose / Q000378:metabolism
D000143:Acids; D010710:Phosphates; C012980:fluorophosphate; D013395:Sucrose; D012969:Sodium Fluoride; D005459:Fluorides