Loss of HLA-A,B,C in colorectal carcinoma is related to the degree of de-differentiation.
By means of immunoperoxidase staining of frozen sections 100 primary colorectal carcinomas and 19 metastases were studied for the expression of HLA-A,B,C antigens. A substantial number of the tumours showed a deficient class I expression. The loss of HLA-A,B,C correlated with the degree of de-differentiation.
Momburg
F
F
Möller
P
P
Moldenhauer
G
G
Hämmerling
G J
GJ
D002454:Cell Differentiation; D003110:Colonic Neoplasms / Q000276:immunology* / Q000473:pathology; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006801:Humans; D012004:Rectal Neoplasms / Q000276:immunology* / Q000473:pathology
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens