title: The fragile X in cattle.
abstract: In search of an animal model for the human fragile X syndrome, the chromosomes of Holstein cows were examined. This breed was chosen because of previous studies on the baldy calf syndrome. An achromatic gap was observed at a specific site on the X chromosome closer to the centromere than that identified in humans. This unstained gap was found in 3%-4% of cells of the following four animals: an affected calf, her sister, their mother, and an unrelated Holstein cow. The bovine fragile X may not be analogous to the human fragile X but its location may be important as a genetic marker in linkage studies involving the loci for hypoxanthine phosphoribosyltransferase (HPRT) and glucose-6-phosphate dehydrogenase (G-6-PD).
authors.forename: I A
authors.initials: IA
authors.lastname: Uchida
authors.forename: V C
authors.initials: VC
authors.lastname: Freeman
authors.forename: P K
authors.initials: PK
authors.lastname: Basrur
mesh_terms: D000505:Alopecia / Q000235:genetics / Q000662:veterinary; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics*; D004195:Disease Models, Animal; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics / Q000662:veterinary*; D008040:Genetic Linkage; D005819:Genetic Markers; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D012729:Sex Chromosome Aberrations / Q000662:veterinary*
chemical_list: D005819:Genetic Markers; D005954:Glucosephosphate Dehydrogenase; D007041:Hypoxanthine Phosphoribosyltransferase