A retrospective comparison of delirium tremens cases before and after the availability of chlormethiazole.
To assess the contribution of chlormethiazole to the treatment of delirium tremens (DT), a retrospective analysis was carried out on cases of DT admitted to the Department of Psychiatry, University of Tübingen, West Germany before and after the introduction of chlormethiazole. Following the introduction of chlormethiazole, there was a significant reduction in DT mortality and in duration of DTs. The age and sex distribution of cases of DT were compared and were found to be similar before and after the introduction of chlormethiazole. The incidence of complications in the two periods were analysed. The dose of chlormethiazole on the first 4 days of DT and the doses of additional psychoactive drugs were also noted.
Schied
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HW
Kimmerle
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Braunschweiger
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M
D000284:Administration, Oral; D000328:Adult; D000430:Alcohol Withdrawal Delirium / Q000188:drug therapy* / Q000401:mortality; D002719:Chlormethiazole / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005860:Germany, West; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D011604:Psychoses, Alcoholic / Q000188:drug therapy*; D012189:Retrospective Studies; D012306:Risk
D002719:Chlormethiazole