Accumulation of indium-111-labeled neutrophils and gallium-67 citrate in rabbit abscesses.
A rabbit abscess model was developed to study the effect of abscess age on the accumulation of indium-111-labeled neutrophils ([111In]N) versus gallium-67 citrate (67Ga). Abscesses 1-2 hr, 6-8 hr, 24 hr, and 7 days old were induced by subcutaneous injection of autoclaved colon contents prior to i.v. administration of either [111In]N or 67Ga. Radioactivity in the abscesses was determined 48 hr postinjection. Accumulation of [111In]N was inversely proportional to abscess age. Seven-day-old abscesses were inconsistently seen on [111In]N scans. In contrast, 67Ga accumulation was not affected by abscess age and all abscesses could be identified on a scan 48 hr postinjection. Scans with [111In]N were clearly superior to 67Ga scans for demonstrating early abscesses. Since 67Ga accumulated to a greater extent than [111In]N in abscesses 7 days old, it may be a superior imaging agent for older abscesses.
Bitar
R A
RA
Scheffel
U
U
Murphy
P A
PA
Bartlett
J G
JG
D000038:Abscess / Q000000981:diagnostic imaging* / Q000378:metabolism; D000818:Animals; D004912:Erythrocytes; D005710:Gallium Radioisotopes / Q000378:metabolism; D007204:Indium / Q000378:metabolism; D009504:Neutrophils; D011817:Rabbits; D011868:Radioisotopes / Q000378:metabolism; D011877:Radionuclide Imaging; D012871:Skin Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism; D013997:Time Factors; D014168:Transferrin / Q000378:metabolism
D005710:Gallium Radioisotopes; D011868:Radioisotopes; D014168:Transferrin; D007204:Indium