title: [Transfer of cefotetan into exudates from excoriated skin wounds].
abstract: Transfer of cefotetan (CTT) into exudates from excoriated skin wounds was studied in 9 adult patients. Each subject was given an intravenous bolus injection of 50 mg/kg of body weight. Concentrations of CTT in serum and in exudate fluid were determined by bioassay using Escherichia coli NIHJ as the test organism. The mean (+/- S.D.) CTT concentration in serum reached 274.3 +/- 78.3 micrograms/ml at 30 minutes after the injection and decreased to 30.0 +/- 12.0 micrograms/ml at 8 hours after the injection. The peak value of CTT in exudate fluid was 143.1 +/- 22.3 micrograms/ml at 1 hour. Eight hours after the injection, the mean concentration in the exudate was 25.7 +/- 21.1 micrograms/ml. The data obtained were analysed pharmacokinetically: CTT concentrations in serum were analysed by two-compartment model, and those in exudate fluid from excoriated skin wounds were analysed by the model in which skin was considered as a small part of the peripheral compartment. Thus T1/2(beta) of CTT levels in serum was calculated as 2.38 hours, AUC0----infinity was 1,000.2 micrograms X hr/ml and Vd was 164.5 ml/kg. Tmax and Cmax of CTT levels in exudates were calculated as 1.05 hours and 131.2 micrograms/ml, respectively.
authors.forename: H
authors.initials: H
authors.lastname: Sugiyama
authors.forename: T
authors.initials: T
authors.lastname: Hatano
authors.forename: K
authors.initials: K
authors.lastname: Takayanagi
authors.forename: H
authors.initials: H
authors.lastname: Aoyama
authors.forename: Y
authors.initials: Y
authors.lastname: Kikuchi
mesh_terms: D000328:Adult; D015313:Cefotetan; D002513:Cephamycins / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D005122:Exudates and Transudates / Q000378:metabolism; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000293:injuries*; D014950:Wounds, Penetrating / Q000378:metabolism*
chemical_list: D002513:Cephamycins; D015313:Cefotetan