title: The use of antibiotics in orthopaedic surgery. Total joint single- v multiple-dose prophylaxis.
abstract: In summary, I can assure you that if you give high-dose antibiotics at the time of operation, it is possible to show--either by bioassay techniques or by laboratory studies--that antibiotics reach the tissue at the time of operation. They lie within the fluid spaces in bone and are effective against the pathogenic organisms.
authors.affiliation: University of Edinburgh, Princess Margaret Rose Hospital, Fairmilehead, Edinburgh, Scotland.
authors.forename: S P
authors.initials: SP
authors.lastname: Hughes
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001842:Bone and Bones / Q000378:metabolism; D006801:Humans; D007595:Joint Prosthesis; D009985:Orthopedics; D011292:Premedication; D013530:Surgical Wound Infection / Q000378:metabolism / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents