Maternal PKU: strategies for dietary treatment and monitoring compliance.
Blood phenylalanine and the metabolites of phenylalanine can be dramatically lowered in pregnant PKU mothers. Special formulas and a strict protocol should be used to achieve diet control and adequate compliance. Levels of blood phenylalanine of 4 mg/dl and lower can be achieved and are preferable to higher levels. The problem of treatment postconception may lead to limited success, as in our case. In order to achieve optimal results, blood phenylalanine should be controlled at or before conception. Since it is difficult to return patients to diet who have been taken off phenylalanine restriction, diet therapy for PKU should not be discontinued at any age.
Matalon
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Michals
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Gleason
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D000293:Adolescent; D000328:Adult; D005260:Female; D005526:Food, Formulated; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010349:Patient Compliance; D010649:Phenylalanine / Q000097:blood; D010661:Phenylketonurias / Q000178:diet therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000178:diet therapy*
D010649:Phenylalanine