[Clinical study on the tissue distribution of cefmenoxime in the field of otolaryngology].
Concentrations of cefmenoxime (CMX) in serum and tissue were determined in surgical patients with chronic sinusitis, maxillary cyst or chronic tonsillitis. CMX was intravenously administered in a dose of 1 gram. Thirty minutes after the administration, patients were operated under local anesthesia. Concentrations of CMX in tissues were determined 1 hour after administration, and were 15.8 micrograms/g and 20.3 micrograms/g in mucous membrane of maxillary sinus and maxillary cyst. CMX was not detectable in tonsils of 8 patients out of 11 examined. An examination of MIC against various bacteria isolated from sinus pus and pharyngeal swab indicated that CMX was effective enough to produce a prophylactic effect against otolaryngo-infections.
Fujita
K
K
Yokoyama
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000517:prevention & control*; D015281:Cefmenoxime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010038:Otorhinolaryngologic Diseases / Q000601:surgery*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014018:Tissue Distribution
D015281:Cefmenoxime; D002439:Cefotaxime