[Rearrangement of the short arm of chromosome 12 in chronic myelomonocytic leukemias].
A rearrangement of the short arm of chromosome #12 with a breakpoint at band 12 was found in 4 out of 15 patients with CMML: two deletions, one simple translocation (9;12)(p21;p12) and one complex t(11;12;13)(p11;p12;q21). Their haematological and clinical characteristics were investigated together with those of 5 other similar published cases. Although this alteration is not very frequent in this myelodysplastic syndrome, and is also found in various other malignant blood disorders, it is clearly a non-random phenomenon, the consequences of which are discussed.
Tanzer
J
J
Lessard
M
M
Guilhot
F
F
Brizard
A
A
D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002881:Chromosomes, Human, Pair 12; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*
Remaniement du petit bras du chromosome 12 dans les leucémies myélomonocytaires chroniques (LMMC).