title: Immunity to Acanthamoeba culbertsoni: experimental studies with Acanthamoeba and control antigen preparations.
abstract: Mice were intranasally immunized with living and killed Acanthamoeba as well as culture supernatant, living Toxoplasma and BCG, and challenged with pathogenic A. culbertsoni strain A-1. The best protection was achieved with killed amoebae of the same strain. A high rate of mortality was observed in immunized mice treated with immunosuppressives and challenged with A. culbertsoni A-1. The significance of the results in relation to environmental human infection is discussed.
authors.affiliation: Department of Clinical Parasitology, Robert-Koch-Institute, Berlin, German Federal Republic.
authors.forename: C R
authors.initials: CR
authors.lastname: Bhaduri
authors.forename: K
authors.initials: K
authors.lastname: Janitschke
authors.forename: K N
authors.initials: KN
authors.lastname: Masihi
mesh_terms: D000048:Acanthamoeba / Q000276:immunology*; D000281:Administration, Intranasal; D000562:Amebiasis / Q000517:prevention & control*; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D007114:Immunization; D051379:Mice
chemical_list: D000953:Antigens, Protozoan