Reciprocal translocation (11;19)(q23;p13) in congenital acute lymphoblastic leukemia.
The cytogenetic, clinical, and immunologic findings ina 4-month-old girl with acute lymphoblastic leukemia (ALL) are reported. The malignant lymphoblasts were characterized cytogenetically by the reciprocal translocation t(11;19)(q23;p13); immunologically by an immature pre-B-ALL phenotype. In spite of the high-risk nature of the leukemia, the patient attained complete remission relatively quickly and is still free of disease 3 years after diagnosis. Because the only two previously reported ALL patients with t(11;19) also seem to have responded well to therapy, this cytogenetic abnormality might turn out to be an indicator of favorable prognosis in ALL.
Heim
S
S
Kristoffersson
U
U
Mandahl
N
N
Mitelman
F
F
Bekassy
A N
AN
Garwicz
S
S
Heldrup
J
J
Wiebe
T
T
D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000151:congenital* / Q000235:genetics; D014178:Translocation, Genetic