A comparative study of the brain uptake and early kinetics of 99mTc-dl HM-PAO and other PnAO derivatives in baboons.
Derivatives of propylene-amine-oxime (PnAO) have been synthesized which form a neutral lipid-soluble complex with 96mTc and can be supplied as freeze-dried kits. The complexes cross the intact blood-brain barrier. This report shows the brain uptake, early kinetics and biodistribution in normal adult baboons of 5 99mTc-PnAO derivatives and 2 isomers of one of the tested derivatives (HM-PAO). The brain uptake of the favoured dl-isomer of HM-PAO reaches its maximum of 4.3% (whole brain/whole body) 1 min p.i. and a clearance of less than 8% was observed 23 min p.i.
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D008024:Ligands; D008297:Male; D010091:Oximes / Q000378:metabolism*; D010215:Papio; D011437:Propylamines / Q000378:metabolism; D013667:Technetium / Q000378:metabolism*; D019690:Technetium Tc 99m Exametazime; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D008024:Ligands; D010091:Oximes; D011437:Propylamines; D019690:Technetium Tc 99m Exametazime; D013667:Technetium