Lymphocyte surface marker studies in the diagnosis of unexplained lymphocytosis.
Fifty-six patients with unexplained lymphocytosis were investigated with a panel of antibodies to lymphocyte surface antigens. In 23 the distribution of cell surface markers suggested reactive lymphocytosis. The remaining 33 patients showed a distribution of cell surface markers that indicated or suggested a diagnosis of B-cell lymphoproliferative disease. Two illustrative case reports show how such studies performed early in the investigation of unexplained lymphocytosis may permit earlier diagnosis of the underlying mechanism.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology; D002452:Cell Count; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008218:Lymphocytosis / Q000175:diagnosis* / Q000276:immunology; D008232:Lymphoproliferative Disorders / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology
D000954:Antigens, Surface