Digital and radial artery blood flow in patients with Raynaud's phenomenon in response to nifedipine.
The effect of nifedipine on haemodynamic changes in the hand after cooling in 10 patients with Raynaud's phenomenon is assessed. Nifedipine reduced the fall in digit blood flow induced by cooling and limited the increase in pulsatility index (a measure of peripheral resistance). There was good correlation between digital arterial inflow (measured by strain gauge plethysmography) and radial artery pulsatility index (measured by Doppler waveform analysis).
D000328:Adult; D001132:Arm / Q000098:blood supply; D004311:Double-Blind Method; D005260:Female; D005385:Fingers / Q000098:blood supply*; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use*; D010991:Plethysmography; D011928:Raynaud Disease / Q000188:drug therapy*; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D009543:Nifedipine