Modulation of lens-induced uveitis by dimethyl sulfoxide.
Experimental lens-induced uveitis was produced in Lewis rats by sensitization with bovine lens protein prior to disruption of the lens capsule. Treatment of these animals by intraperitoneal injection of dimethyl sulfoxide resulted in reduction in retinal vasculitis, hemorrhage and necrosis. Furthermore, morphometric analysis of choroidal inflammation revealed significant reduction of choroidal thickness in the treated animals. These findings suggest that hydroxyl radicals play a role in producing ocular tissue damage in the acute Arthus-type of ocular inflammation.
D000818:Animals; D002417:Cattle; D003459:Crystallins; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D007903:Lens Capsule, Crystalline / Q000293:injuries*; D007908:Lens, Crystalline / Q000293:injuries*; D051381:Rats; D011917:Rats, Inbred Lew; D014605:Uveitis / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D014950:Wounds, Penetrating / Q000150:complications*
D003459:Crystallins; D004121:Dimethyl Sulfoxide