title: Re-attachment of periodontal ligament by collagen in experimentally-induced alveolar bone dehiscence in dogs.
abstract: Fifty-four bone dehiscences were made in nine dogs by reflecting mucoperiosteal flaps on the labial aspect of lower and upper incisors and premolars and removing alveolar bone. One half of the dehiscences were treated with native enriched collagen solution (ECS) prepared from acid-soluble dog-skin collagen. Six weeks later, histologic sections were prepared from both the ECS-treated and untreated control sites. Re-attachment was promoted by the ECS preparation; there was arrest of epithelial migration apically and formation of new bone and cementum, as well as proliferation of fibrous connective tissue that became attached to the newly-formed cementum. This effect could be due to an influence of ECS on the chemotaxis of connective-tissue cells and to an anti-migratory (barrier) effect on gingival epithelium.
mesh_terms: D000539:Alveolar Process / Q000473:pathology / Q000502:physiology*; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D001862:Bone Resorption / Q000188:drug therapy* / Q000473:pathology; D002465:Cell Movement; D003094:Collagen / Q000627:therapeutic use*; D004285:Dogs; D004848:Epithelium / Q000502:physiology; D010510:Periodontal Diseases / Q000188:drug therapy / Q000473:pathology; D010513:Periodontal Ligament / Q000187:drug effects / Q000502:physiology*
chemical_list: D003094:Collagen