[Assessment of the effect of prospidin and cyclophosphane on the indices of the T and B immune responses in vitro].
Prospidin was shown to produce a decrease of receptors on T- and B-lymphocytes and T-subpopulations, to inhibit migration of leucocytes under the influence of the antigenic stimulus, to reduce the cytopathic activity of lymphocytes and the level of secreted immunoglobulins of the main classes. The degree of prospidin immunodepressive effect is compared with that of cyclophosphane.
D000293:Adolescent; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002464:Cell Migration Inhibition; D003520:Cyclophosphamide / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D066298:In Vitro Techniques; D008875:Middle Aged; D010879:Piperazines / Q000494:pharmacology*; D011447:Prospidium / Q000494:pharmacology*; D011971:Receptors, Immunologic / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D007136:Immunoglobulins; D010879:Piperazines; D011971:Receptors, Immunologic; D011447:Prospidium; D003520:Cyclophosphamide
Otsenka vliianiia prospidina i tsiklofosfana na pokazateli T- i B-immunnogo otveta in vitro.