Histological analysis of lymphocyte subsets infiltrated into mouse tumor tissue exposed to local irradiation.
The subsets of lymphocytes infiltrated into mouse tumor tissue exposed to irradiation were analyzed by the avidin-biotin-peroxidase procedure using monoclonal antibodies. The effect of PSK administration was also analyzed. Microscopic observation revealed the intense lymphocytic reactions in the exposed tumor, especially 7 days after irradiation of 20 Gy, which mainly consisted of anti-L3T4 positive cells, whereas the degree of infiltration was lower in the nonexposed tumor. PSK was found to enhance T lymphocyte subset infiltration into the exposed tumor tissue.
D000818:Animals; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy*; D011509:Proteoglycans / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D013601:T-Lymphocytes / Q000145:classification / Q000473:pathology*
D011509:Proteoglycans; C010770:polysaccharide-K