Decreased activities of serine proteinases in spleen of various murine models of systemic lupus erythematodes.
Previous studies indicated a relationship between immune deficiencies and abnormalities in the activities of various hydrolytic enzymes, including proteinases, in tissues. In the present study, we compared such activities in spleen among the three types of murine models of systemic lupus erythematodes (SLE) (i.e., New Zealand black/white mouse, MRL mouse, and BXSB mouse) and their controls. According to the results of multivariate analysis, it was shown that the most important enzymatic changes differentiating the pathologic animals from their controls were decreases in the activities of serine proteinases. Judging from the behavior of these enzymes in various immunological disturbances, it is likely that they play some important roles in pathophysiology of SLE.
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008180:Lupus Erythematosus, Systemic / Q000201:enzymology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012697:Serine Endopeptidases / Q000378:metabolism*; D013154:Spleen / Q000201:enzymology*
D012697:Serine Endopeptidases