title: Chronic idiopathic neutropenia with hypergammaglobulinemia.
abstract: Chronic idiopathic neutropenia can occur in spite of the normocellular bone marrow in myeloid series with or without anti-neutrophilic antibody. We report a patient with chronic neutropenia and severe polyclonal hypergammaglobulinemia. The patient demonstrated a positive anti-neutrophil antibody by fluorocytometry, although granulocyte-specific anti-nuclear factor and anti-stem cell (CFU-GM) antibody were negative. Thus, neutropenia of this patient appeared to be due to the antibody-mediated destruction of neutrophils. Both neutropenia and hypergammaglobulinemia were normalized by the administration of prednisone.
mesh_terms: D000368:Aged; D000380:Agranulocytosis / Q000150:complications*; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D001853:Bone Marrow / Q000276:immunology; D002908:Chronic Disease; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000276:immunology; D008297:Male; D009503:Neutropenia / Q000150:complications* / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D013234:Stem Cells / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies