Activation of the classical complement pathway by BioRex-70.
The cation exchange resin BioRex-70 was able to activate the classical complement pathway in human serum at 37 degrees C over the resin concentration range 0-5% (v/v). Using zymosan-treated human serum, it was found that the activation proceeded as far as complement protein C3.
D002411:Cation Exchange Resins / Q000494:pharmacology*; D003166:Complement Activating Enzymes / Q000302:isolation & purification; D003167:Complement Activation / Q000187:drug effects*; D003172:Complement C1 / Q000302:isolation & purification; D015922:Complement C1q; D003176:Complement C3 / Q000378:metabolism; D003171:Complement Pathway, Classical / Q000187:drug effects*; D006801:Humans; D007457:Iodine Radioisotopes; D007475:Ion Exchange Resins / Q000494:pharmacology*; D011485:Protein Binding; D012117:Resins, Synthetic; D015054:Zymosan / Q000494:pharmacology
D002411:Cation Exchange Resins; D003172:Complement C1; D003176:Complement C3; D007457:Iodine Radioisotopes; D007475:Ion Exchange Resins; D012117:Resins, Synthetic; D015922:Complement C1q; D015054:Zymosan; C026257:Bio-Rex 70; D003166:Complement Activating Enzymes