[Lymphocyte-mediated modulation of the functional activity of macrophages by individual antigenic complexes of Trichophyton cells].
The capacity of antigenic complexes of the causative agent of zoo- and anthroponotic trichophytosis for inducing the factors, that modify the functional activity of macrophages, in mice and in spleen cell cultures has been studied. These complexes are capable of inducing the T-lymphocyte-mediated suppression and of stimulating the fungicidal activity (and oxygen-dependent metabolism) of phagocytes. The production of fungicidal activity suppressing lymphokines is linked with the presence of alkali-insoluble components of fungal cell walls and cytoplasmic antigens (the latter appear only in interactions of antigens with the lymphocytes of immunized animals) in the above-mentioned complexes.
D000818:Animals; D000946:Antigens, Fungal / Q000276:immunology*; D002473:Cell Wall / Q000276:immunology; D002478:Cells, Cultured; D003593:Cytoplasm / Q000276:immunology; D007114:Immunization; D008222:Lymphokines / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors; D014249:Trichophyton / Q000276:immunology*
D000946:Antigens, Fungal; D008222:Lymphokines
Limfotsitoposredovannaia moduliatsiia funktsional'noĭ aktivnosti makrofagov otdel'nymi antigennymi kompleksami kletok trikhofitona.