Effect of the late complement components C5b-9 on human monocytes: release of prostanoids, oxygen radicals and of a factor inducing cell proliferation.
Recently, we reported stimulation of rat macrophages and human platelets by isolated C5b-9 to synthesize prostaglandin E (PGE) or thromboxane B2 (TXB2). In the present study, we tested whether besides prostanoids, C5b-9 also would induce the production of other mediators. We found that C5b-9 in sublytic concentrations stimulated human granulocytes (polymorphonuclear leukocytes) or monocytes to release oxygen radicals. Furthermore, monocytes release interleukin-1 in response to C5b-9. Thus, besides having a lytic capacity, C5b-9 also functions as a stimulator of various cells.
D015938:Complement Membrane Attack Complex; D003165:Complement System Proteins / Q000494:pharmacology*; D005609:Free Radicals; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D010100:Oxygen / Q000096:biosynthesis*; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011458:Prostaglandins E / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical; D013929:Thromboxane B2 / Q000378:metabolism*
D015938:Complement Membrane Attack Complex; D005609:Free Radicals; D007375:Interleukin-1; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D013929:Thromboxane B2; D003165:Complement System Proteins; D010100:Oxygen