Antibody-induced modulation of H-2Kb antigens on mouse tumor cells in vitro.
Modulation of H-2Kb antigens on cells of a subline of the murine Lewis lung carcinoma was induced in vitro by a monoclonal antibody with specificity for H-2Kb antigens. High antibody concentrations resulted in a more spherical morphology of the cells, in a discrete loss of all antibody-antigen complexes within 4-6 hr, and in a corresponding maximal decrease in the total cellular antigen content 6-8 hr after antibody exposure. Restoration was complete within 2 hr after removal of the complexed antigen and occurred without any visible cap formation.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000302:isolation & purification; D006183:H-2 Antigens / Q000032:analysis / Q000276:immunology*; D007399:Interphase; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology; D008285:Major Histocompatibility Complex; D051379:Mice
D000911:Antibodies, Monoclonal; D006183:H-2 Antigens; C032876:H-2Kb protein, mouse