title: Synthesis and some biological properties of 2-xanthonylalkyl-(alkoxy) carboxylic acids.
abstract: 2-Xanthonylacetic acids 5a-5d and alpha-methyl-2-xanthonyloxyacetic acid 8 were obtained as potential anti-inflammatory compounds. Preliminary evaluation was carried out for anti-inflammatory and analgesic activity of acids 5a, 5c and 5d and for inhibition of blood platelets aggregation by compounds 5a-5d and 8. In the inhibition of carrageenin-induced rat edema the highest activity shown by acids 5a and 5c was similar to that of ketoprofen.
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D007660:Ketoprofen / Q000494:pharmacology; D008297:Male; D051379:Mice; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013055:Spectrophotometry, Infrared; D014966:Xanthenes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002264:Carboxylic Acids; D014966:Xanthenes; D007660:Ketoprofen