[Natural killers in pregnancy: the problem of heterogeneity and the regulation of activity].
Natural killer activity of pregnant women's peripheral blood lymphocytes and of cord blood was investigated. 3H-uridine labeled K-562 and human embryo fibroblasts (HEF) were used as target cells in cytotoxic test. The results of competitive inhibition test led us to a conclusion about the presence of some common K-562 and HEF surface structures recognized by NK cells. It was shown that the decline of NK activity of pregnant women and a low NK activity of cord blood were not associated with the influence of T-lymphocytes or adherent cells.
D001782:Blood Donors; D002448:Cell Adhesion; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D011247:Pregnancy / Q000276:immunology*; D011261:Pregnancy Trimester, First; D011263:Pregnancy Trimester, Third; D013601:T-Lymphocytes / Q000276:immunology
Estestvennye killery pri beremennosti: problema geterogennosti i reguliatsiia aktivnosti.