title: The chemotherapy of rodent malaria XLI. Causal prophylaxis. Part V. Effect of mefloquine on exoerythrocytic schizogony in Plasmodium yoelii yoelii.
abstract: Previous studies using mefloquine in rodents have suggested that this compound has no effect on pre-erythrocytic schizogony. In the present study, direct observations on 46-hour-old pre-erythrocytic schizonts of P. yoelii in the liver of rats have shown that mefloquine does induce recognizable changes in the peripheral, enzyme-containing vesicles but that these are insufficient to hinder the maturation of the parasites, thus confirming that this compound has no causal prophylactic value.
mesh_terms: D000818:Animals; D008099:Liver / Q000473:pathology / Q000648:ultrastructure; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D015767:Mefloquine; D010967:Plasmodium yoelii / Q000187:drug effects* / Q000648:ultrastructure; D011804:Quinolines / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011804:Quinolines; D015767:Mefloquine