HLA-DR+/T6- Langerhans cells of the human cornea.
We have investigated normal human corneas for the presence of T6-marker on Langerhans cells. With the exception of one pair of newborn corneas and two pairs of very young infant corneas, all HLA-DR-positive cells in central and peripheral corneal epithelium were T6-negative by double-labeled immunofluorescence. In contrast, epidermal sheets from normal human eyelid skin displayed positive staining for T6 on most of the HLA-DR-positive Langerhans cells. Since T6 antigen is considered to be a specific Langerhans cell differentiation marker, we interpret this finding to indicate a nonactivated or undifferentiated state of Langerhans cells in normal human corneas.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000276:immunology*; D006681:HLA-D Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007801:Langerhans Cells / Q000276:immunology*; D008875:Middle Aged
D000945:Antigens, Differentiation, T-Lymphocyte; D006681:HLA-D Antigens; D006684:HLA-DR Antigens