[Pharmacokinetics of propofol as an induction agents in adults].
The disposition kinetics of Propofol have been determined in 7 patients (3 men, 4 women) receiving 2.5 mg/kg for induction of anaesthesia. Peripheral venous samples were collected up to 12 hours after injection of the drug. Data analysis indicates a 3 compartment model with a terminal half-life of 480 +/- 141 min, clearance of 0.0352 +/- 0.0014 l/min/kg and volume of distribution of 24.2 +/- 6.2 l/kg.
D000777:Anesthetics / Q000097:blood*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D010636:Phenols / Q000097:blood* / Q000493:pharmacokinetics; D015742:Propofol
D000777:Anesthetics; D010636:Phenols; D015742:Propofol
Pharmacocinétique du propofol comme agent d'induction chez l'adulte.