title: Effect of tamoxifen on pokeweed mitogen stimulated immunoglobulin secretion in vitro.
abstract: The influence of Tamoxifen on pokeweed mitogen induced immunoglobulin (Ig) secretion of human blood lymphocytes was tested in vitro. It was observed that pretreatment of T cell enriched preparations with "therapeutic" concentrations of Tamoxifen augmented their capacity to promote IgG but not IgM secretion of untreated autologous B-lymphocytes. Cultures containing Tamoxifen pretreated B cell enriched preparations and untreated T cells exhibited reduced secretion of both IgG and IgM.
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D008875:Middle Aged; D011043:Pokeweed Mitogens / Q000494:pharmacology*; D013629:Tamoxifen / Q000494:pharmacology*
chemical_list: D007136:Immunoglobulins; D011043:Pokeweed Mitogens; D013629:Tamoxifen