Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity.
Mutations that eliminated the ability of the human T-cell lymphotropic virus type III to produce the 27-kilodalton 3' orf product did not eliminate the ability of the virus to replicate in and kill T4+ cells. A mutant carrying a mutation that deleted carboxy-terminal sequences from the envelope gene as well as the 3' orf sequences retained the ability to kill T4+ lymphocytes, but had a retarded replication rate.
D002460:Cell Line; D002470:Cell Survival; D003588:Cytopathogenic Effect, Viral; D005814:Genes, Viral; D006678:HIV / Q000235:genetics* / Q000502:physiology; D009154:Mutation; D012191:Retroviridae Proteins / Q000235:genetics / Q000502:physiology; D013601:T-Lymphocytes / Q000382:microbiology*; D014779:Virus Replication
D012191:Retroviridae Proteins