[Heterogeneity of gastrin-containing G-cells and its expression in gastric adenocarcinomas and endocrine tumors].
The heterogeneity of gastrin-containing G cells present in human gastric mucosa has been examined immunohistochemically. Calcitonin gene-related peptide (CGRP), calcitonin and human chorionic gonadotropin (hCG)-immunoreactivity were detected in about 500, 20 and 10 cells pro 1,000 G cells, respectively, these findings supporting the "one cell, multi-hormone theory". Gastrin, calcitonin immunoreactive tumor cells were demonstrated in 13%, 3% of the antral adenocarcinomas and 17% and 10% of antral endocrine tumors, but they were not found in fundic adenocarcinomas and endocrine tumors. Cell hybridization between the tumor cell and the G-cell might be a possible mechanism for the occurrence of gastric and calcitonin in the gastric tumors. HCG-immunoreactive tumor cells were detected in 27% of antral adenocarcinomas, and in 24% of the fundic adenocarcinomas, and the production of hCG by gastric tumor cells might be based on the gene expression during carcinogenesis, regardless of the tumor localization.
D000230:Adenocarcinoma / Q000473:pathology*; D002116:Calcitonin / Q000032:analysis; D015740:Calcitonin Gene-Related Peptide; D002277:Carcinoma / Q000473:pathology*; D006063:Chorionic Gonadotropin / Q000032:analysis; D004381:Duodenal Ulcer / Q000473:pathology; D005753:Gastric Mucosa / Q000032:analysis*; D005755:Gastrins / Q000032:analysis*; D006801:Humans; D007120:Immunochemistry; D009479:Neuropeptides / Q000032:analysis; D011706:Pyloric Antrum / Q000032:analysis; D013274:Stomach Neoplasms / Q000473:pathology*
D006063:Chorionic Gonadotropin; D005755:Gastrins; D009479:Neuropeptides; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide