[Action of cobamamide and leukovorin on skeletal muscle reinnervation in mechanical injury to the motor nerves].
The experiments on rats showed that cobamamide (0.5 mg/kg) and leukovorin (5 mg/kg) administered daily exerted a pronounced activating effect on the process of regeneration of mechanically injured nerve trunks. The combined administration of the drugs fails to potentiate the effect of each drug on the process of the skeletal muscle reinnervation.
D000818:Animals; D003038:Cobamides / Q000494:pharmacology*; D004357:Drug Synergism; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D002955:Leucovorin / Q000494:pharmacology*; D008297:Male; D009132:Muscles / Q000201:enzymology / Q000293:injuries / Q000294:innervation*; D009416:Nerve Regeneration / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D003038:Cobamides; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; C000913:cobamamide; D002955:Leucovorin
Vozdeĭstvie kobamamida i leĭkovorina na protsessy reinnervatsii skeletnykh myshts pri mekhanicheskoĭ travme motornykh nervov.