title: Search for genetic variation in the blood of Norwegian dairy goats reveals a new polymorphism at the Hb beta A locus.
abstract: A total of 150 blood samples tested for serum albumin and transferrin and for red cell carbonic anhydrase, phosphoglucomutase, phosphogluconate dehydrogenase, phosphohexose isomerase, nucleoside phosphorylase, acid phosphatase, 'X'-protein and potassium concentration only showed variation at the 'X' protein and nucleoside phosphorylase loci. Isoelectric focusing over pH range 6-8 showed 145 samples to be of haemoglobin type A and 5 type AD. The haemoglobin A type was resolved into further types by separation over pH 6.9-7.5 in Immobiline polyacrylamide gels. A 2- or 4-band pattern was present in 136 of the samples; a genetic hypothesis based on four or more different haemoglobin A variants is proposed. 14 samples had a 3-, 5- or 6-band pattern. It is assumed that these are heterozygous for a variant of the II alpha gene.
mesh_terms: D000818:Animals; D005819:Genetic Markers; D005914:Globins / Q000235:genetics*; D006041:Goats / Q000235:genetics*; D007525:Isoelectric Focusing; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers; D005914:Globins