[The use of mexamine to reduce radiation injuries during embryogenesis of Wistar rats].
In experiments with 330 Wistar rats experiencing their first pregnancy and 1430 neonatal rats of the first generation a study was made on the toxicity and radioprotective efficiency of a single subcutaneous injection of 10 mg/kg mexamine on days 3, 11 and 19 of pregnancy. The agent caused various abnormalities in pregnancy, delivery and postnatal development of the offspring of nonirradiated animals, and it was almost ineffective when used for the prevention of radiation damages during the antenatal ontogenesis.
D008735:5-Methoxytryptamine / Q000494:pharmacology*; D000016:Abnormalities, Radiation-Induced / Q000517:prevention & control*; D000818:Animals; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D005720:Gamma Rays; D005865:Gestational Age; D009024:Morphogenesis / Q000528:radiation effects; D011247:Pregnancy; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014363:Tryptamines / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D014363:Tryptamines; D008735:5-Methoxytryptamine
Oput primeneniia meksamina dlia snizheniia luchevykh narusheniĭ v émbriogeneze krys Vistar.