title: Cerebral metabolism in chronic ocular ischemia.
abstract: Two patients with neovascular glaucoma presented an obstruction in the internal carotid artery and reverse flow of blood through the ophthalmic artery, a so-called ophthalmic artery steal phenomenon, on digital subtraction angiography. To study the cerebral metabolic state maintained by this mechanism, the same patients underwent positron emission tomography. Both displayed decreased regional cerebral blood flow, reduced regional cerebral metabolic rate for oxygen and for glucose and increased regional oxygen and glucose extraction ratios. In our patients with chronic ocular ischemia, the cerebral perfusion maintained by the ophthalmic artery steal phenomenon was in the critical state called misery perfusion.
mesh_terms: D001921:Brain / Q000378:metabolism*; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D002908:Chronic Disease; D005901:Glaucoma / Q000503:physiopathology; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D010101:Oxygen Consumption; D012160:Retina / Q000098:blood supply*; D014055:Tomography, Emission-Computed
chemical_list: D005947:Glucose