title: Nifedipine in the treatment of hypertension in systemic lupus erythematosus.
abstract: Treatment of hypertension in systemic lupus erythematosus (SLE) may be complicated by unwanted immunologic vascular and renal side effects of drugs. The safety of long-acting nifedipine tablets was studied in 8 SLE hypertensive subjects for six months. Nifedipine reduced blood pressure from a mean 151.9 +/- 10/103.7 +/- 8.6 mmHg to a mean of 130 +/- 14.1/87.5 +/- 5 mmHg. There was no deterioration of renal function or of hematologic or immunologic indices during that period. We believe nifedipine is a safe and effective hypotensive drug in SLE, either alone or combined with beta blockers and diuretics.
mesh_terms: D000906:Antibodies / Q000032:analysis; D000974:Antibodies, Antinuclear / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D003165:Complement System Proteins / Q000032:analysis; D004247:DNA / Q000276:immunology; D004341:Drug Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000503:physiopathology; D008297:Male; D009543:Nifedipine / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000906:Antibodies; D000974:Antibodies, Antinuclear; D003165:Complement System Proteins; D004247:DNA; D009543:Nifedipine