Effect of food and various antacids on the absorption of tenoxicam.
1 Twelve healthy volunteers received a single oral dose of tenoxicam 20 mg on six occasions separated by 3 weeks. 2 The six occasions were: fasted overnight; postprandial; fasting and 15 ml aluminium hydroxide gel; postprandial and 15 ml aluminium hydroxide gel; fasting and 15 ml aluminium and magnesium hydroxide gel; postprandial and 15 ml aluminium and magnesium hydroxide gel. 3 Twenty plasma samples were collected over 15 days following dosing with tenoxicam. 4 The following kinetic parameters for plasma tenoxicam were compared: peak concentrations, time taken to reach peak concentrations, area under the plasma concentration-time curve (AUC) and half-life of elimination. 5 Food lengthened the time taken to reach peak tenoxicam concentrations (5.82 +/- 4.6 vs 1.84 +/- 1.0 h in the fasting state; P less than 0.02) and marginally reduced the peak concentrations achieved. AUC was not affected by any of the different regimens. 6 These effects of food on tenoxicam bioavailability are unlikely to be of clinical significance during chronic dosing with the drug.
D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology; D000863:Antacids / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D001682:Biological Availability; D005260:Female; D005502:Food; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008276:Magnesium Hydroxide / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D000863:Antacids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; D000536:Aluminum Hydroxide; D008276:Magnesium Hydroxide; C032801:tenoxicam