Jejunal crypt stem-cell survival after fractionated gamma-irradiation performed at different dose rates.
Jejunal crypt survival after fractionated total body irradiation of C3H mice given at dose rates between 1.2 and 0.08 Gy/min was studied and the results analysed according to the linear quadratic model. Whereas alpha was independent of dose rate beta decreased with dose rate to approach zero at about 0.01 Gy/min. During the period of recovery, sublethal damage from doses given at high dose rate interact with low dose rate irradiation given immediately after, and increases its effectiveness.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D007583:Jejunum / Q000528:radiation effects*; D051379:Mice; D013234:Stem Cells / Q000528:radiation effects
D003037:Cobalt Radioisotopes