Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis.
Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen.
D001171:Arthritis, Juvenile / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003718:Denmark; D005260:Female; D006681:HLA-D Antigens / Q000276:immunology*; D006682:HLA-DP Antigens / Q000032:analysis / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis / Q000276:immunology; D059810:HLA-DR Serological Subtypes; D015805:HLA-DR5 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male
D006681:HLA-D Antigens; D006682:HLA-DP Antigens; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; D015805:HLA-DR5 Antigen; C041559:HLA-DR8 antigen; D000949:Histocompatibility Antigens Class II