title: [Effect of glycylpressin on pressure in esophageal varices in patients with liver cirrhosis and previous hemorrhaging varices].
abstract: In 15 patients with the history of bleeding from esophageal varices, confirmed cirrhosis of the liver (Child A) and esophageal varices (grade II, 2; grade III, 11; and grade IV, 2 patients) esophageal intravariceal pressures were endoscopically measured before and 10 min after intravenous administration of 1 mg glycylpressin. Pressures fell in the patients without previous sclerotherapy from 21.8 +/- 2.8 to 19.0 +/- 1.9 mm Hg (not significant), in those previously sclerosed from 18.0 +/- 1.4 to 14.5 +/- 1.0 mm Hg (p less than 0.05). In two of the non-sclerosed patients and one after sclerotherapy no change of pressure was recorded. The results indicate that glycylpressin has a relatively minor and uncertain effect on esophageal intravariceal pressure. In view of the possible side effects of the drug the indications for its use should be carefully weighed.
mesh_terms: D000328:Adult; D000368:Aged; D004932:Esophageal and Gastric Varices / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000188:drug therapy; D008236:Lypressin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D011312:Pressure; D000077585:Terlipressin
chemical_list: D008236:Lypressin; D000077585:Terlipressin
vernacular_title: Einfluss von Glycylpressin auf den Osophagusvarizendruck bei Patienten mit Leberzirrhose und vorangegangener Varizenblutung.