Synthesis and pharmacological properties of some 2-substituted 1-(3-pyridyl)-1,2,3,4-tetrahydro-beta-carbolines.
Six derivatives of 2-aminoacetyl-1,2,3,4-tetrahydro-beta-carboline (2a-f) were obtained, which yielded as a result of reduction with LiAlH4 six respective 2-aminoethyl-derivatives (3a-f). Pharmacological studies revealed that compounds 2f, 3e and 3f have sedative properties. None of the compounds possesses neuroleptic, antidepressive, anxiolytic, analgesic or anticonvulsant properties.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001058:Apomorphine / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D002243:Carbolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects
D000700:Analgesics; D000927:Anticonvulsants; D002243:Carbolines; D011619:Psychotropic Drugs; D011725:Pyridines; D012110:Reserpine; D006916:5-Hydroxytryptophan; D001058:Apomorphine