title: [In vivo study in healthy volunteers on the effect of tetracycline and cotrimoxazole on chemiluminescence and granulocyte adhesion].
abstract: The influence of tetracycline and cotrimoxazole on polymorphonuclear leukocyte (PMNL) chemiluminescence and adherence to nylon was investigated in vivo on healthy volunteers. A significant impairment of chemiluminescence and (although not statistically significant) an inhibitory effect on adherence to nylon was observed in subjects receiving tetracycline. Cotrimoxazole did not appear to have a significant influence on PMNL function.
mesh_terms: D000328:Adult; D002448:Cell Adhesion / Q000187:drug effects; D004338:Drug Combinations / Q000494:pharmacology; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D008163:Luminescent Measurements; D013420:Sulfamethoxazole / Q000494:pharmacology*; D013752:Tetracycline / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
chemical_list: D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013752:Tetracycline; D013420:Sulfamethoxazole
vernacular_title: Studio "in vivo" in volontari sani sull'effetto di tetraciclina e cotrimoxazolo sulla chemiluminescenza e sull'aderenza granulocitaria.