Association of HLA DR1 with high D-penicillamine binding to monocytes in females.
Binding of D-Penicillamine (D-Pen) to human monocytes was examined by flow cytometry with fluorescent D-Pen conjugate. Cells from HLA DR1-positive healthy females bound significantly more D-Pen than cells from DR1-negative healthy females (P = 0.015), and DR1 was associated with the highest binding among HLA DR antigens. In contrast, DR4 was associated with the lowest binding in healthy females. A difference in D-Pen binding between healthy females who were DR1-positive, DR4-negative and those who were DR1-negative, DR4-positive was statistically significant (P = 0.026). Neither healthy females nor healthy males showed significant associations of D-Pen binding with HLA A, B, or C antigens, nor did healthy males show an association between strength of D-Pen binding and any DR antigens.
D001172:Arthritis, Rheumatoid / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D006801:Humans; D009000:Monocytes / Q000378:metabolism*; D010396:Penicillamine / Q000378:metabolism*
D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D010396:Penicillamine