title: Surgical management of bleeding esophageal varices. Results with 80 cases.
abstract: This report presents results of surgery for bleeding esophageal varices in 80 patients. A prospective randomized study addresses the efficacy of the distal splenorenal shunt (DS) versus the mesocaval shunt (MS) in 50 patients undergoing elective surgery. An additional 30 patients underwent emergency MS for uncontrollable hemorrhage. In the elective series, patients averaged "B" according to Child's Classification. Operative mortality rates were similar (5%). Incidences of encephalopathy were also similar (10%). Those patients undergoing MS experienced an overall operative mortality of 9 per cent, which included emergency shunts (operative mortality 13%). This latter figure is the lowest in the world's literature. Our technique of mesocaval shunting emphasizes short (mean, 3.8-cm) and wide (mean, 21.5-mm) cloth prostheses. Utilizing this approach, we have been able to reduce operative portal venous pressure from a mean (x +/- SE) of 40.1 +/- 1.9 to 13.1 +/- 0.6 cm H2O. The latter value correlated inferior vena caval pressure, 11.8 +/- 0.6 and central venous pressure (recorded by the anesthesiologist) 11.4 +/- 0.5 cm H2O. This is the highest reduction (67%) in portal pressure thus far recorded and reflects our emphasis upon meticulous and extensive dissection of the involved structures. The former minimizes blood loss, which in our hands has been minimal (0.45 +/- 0.18 units per case), reducing the threat of further liver damage; the latter facilitates the "optimal shunt," one which returns portal venous pressure to normal.
mesh_terms: D001807:Blood Vessel Prosthesis; D004932:Esophageal and Gastric Varices / Q000601:surgery*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000601:surgery*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008642:Mesenteric Veins / Q000601:surgery; D008875:Middle Aged; D011169:Portal Vein / Q000503:physiopathology; D011170:Portasystemic Shunt, Surgical / Q000379:methods* / Q000401:mortality; D011446:Prospective Studies; D011897:Random Allocation; D013164:Splenorenal Shunt, Surgical / Q000379:methods / Q000401:mortality; D014667:Vasopressins / Q000008:administration & dosage / Q000494:pharmacology; D014682:Vena Cava, Inferior / Q000601:surgery; D014690:Venous Pressure / Q000187:drug effects
chemical_list: D014667:Vasopressins