title: Efficacy of oral antibiotics for the treatment of persistent otitis media with effusion.
abstract: We followed 137 children who were found to have persistent otitis media with effusion (POME) one month after the diagnosis of acute otitis media. Subjects were randomly assigned to either treatment with erythromycin ethylsuccinate and sulfisoxizole or to no treatment. Follow-up utilizing pneumatic otoscopy and tympanometry showed that treated patients were more likely to have normal findings, and less likely to develop acute otitis media during the month following treatment. These data indicate that children with POME one month following acute otitis media may benefit from an additional course of antibiotics.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D015643:Erythromycin Ethylsuccinate; D006801:Humans; D007223:Infant; D010034:Otitis Media with Effusion / Q000188:drug therapy*; D011897:Random Allocation; D013444:Sulfisoxazole / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D015643:Erythromycin Ethylsuccinate; D004917:Erythromycin; D013444:Sulfisoxazole