[Cooperation between two antiparallel peptide chains covering the major groove of DNA. Molecular model of a poly-lysine/poly-AT complex].
Two antiparallel polypeptide chains oriented 5' to 3' can be adapted upon the central pillar of the major groove of a poly-A, poly-T/DNA. Lysine residues with their epsilon-NH2 fixed on the phosphates can cover the major groove entirely. This model is in accordance with all known properties of poly-lysine/poly-AT complexes. A generalization of this antiparallel disposition would be a U-turn of a single peptide chain, producing a "finger" that can recognize the base-sequence of the major groove.
D004247:DNA; D004268:DNA-Binding Proteins; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009698:Nucleoproteins; D011061:Poly A; D011071:Poly T; D011067:Poly dA-dT; D011107:Polylysine; D011487:Protein Conformation
D004268:DNA-Binding Proteins; D009698:Nucleoproteins; D011061:Poly A; D011071:Poly T; D011107:Polylysine; D011067:Poly dA-dT; D004247:DNA
Coopération de deux chaînes peptidiques antiparallèles recouvrant le grand sillon de l'ADN. Modèle moléculaire de la congruence poly-lysine/poly-AT.