Treatment of sheep with prostaglandin F2 alpha enhances production of a luteal chemoattractant for eosinophils.
Eosinophils were quantitated in sections of luteal tissue obtained from sheep treated with a luteolytic dose of prostaglandin (PG) F2 alpha. Increased numbers of cells were detected before the onset of either functional (decline in sera or tissue concentrations of progesterone) or morphological regression. Luteal tissue was shown to produce a specific chemoattractant for eosinophils as assessed by a linear under-agarose migration assay. Eosinophils were responsive toward leukotriene B4, but not toward PGF2 alpha or a synthetic N-formyl peptide. Because eosinophils are capable of mediating tissue damage in immune/inflammatory conditions, it is suggested that these cells could play a similar role in the mechanics of luteolysis.
D000818:Animals; D002630:Chemotactic Factors / Q000096:biosynthesis*; D002631:Chemotactic Factors, Eosinophil / Q000096:biosynthesis*; D003338:Corpus Luteum / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D015237:Dinoprost; D004804:Eosinophils / Q000166:cytology / Q000276:immunology; D005260:Female; D066298:In Vitro Techniques; D003341:Luteolysis / Q000187:drug effects; D011374:Progesterone / Q000097:blood; D011460:Prostaglandins F / Q000494:pharmacology*; D012756:Sheep
D002630:Chemotactic Factors; D002631:Chemotactic Factors, Eosinophil; D011460:Prostaglandins F; D011374:Progesterone; D015237:Dinoprost