Myocardial imaging using 11C-CoQ10 with positron emission tomography.
The potential of 11C-labeled coenzyme Q10(CoQ10) as a myocardial imaging tracer was explored with positron emission tomography (PET). Serial myocardial imaging studies were performed using 11C-CoQ10, 45Ti-diethylenetriaminepentaacetic acid (45Ti-DTPA), and 2-deoxy-2-[18F]fluoro-D-mannose (18FDM) in the same dog. Cross sectional images of the heart with 11C-CoQ10 showed relatively high radioactivity in the blood pool, when compared with images taken with 18FDM. However, when the blood spillover of radioactivity is adequately corrected with 45Ti-DTPA data, it was found that 11C-CoQ10 accumulated in the myocardium with time.
D000818:Animals; D001810:Blood Volume; D002250:Carbon Radioisotopes; D003067:Coenzymes; D004285:Dogs; D005947:Glucose / Q000378:metabolism; D006321:Heart / Q000000981:diagnostic imaging*; D009206:Myocardium / Q000378:metabolism; D004369:Pentetic Acid; D012210:Rhamnose / Q000031:analogs & derivatives; D014055:Tomography, Emission-Computed; D014451:Ubiquinone / Q000031:analogs & derivatives*
D002250:Carbon Radioisotopes; D003067:Coenzymes; D014451:Ubiquinone; C017190:2-deoxy-2-fluoromannose; D004369:Pentetic Acid; C024989:coenzyme Q10; D005947:Glucose; D012210:Rhamnose