title: The effect of computed tomography noise and tissue heterogeneity on cerebral blood flow determination by xenon-enhanced computed tomography.
abstract: The errors associated with derivation of cerebral blood flow values by the xenon-enhanced computed tomography (CT) method have been evaluated as a function of tissue heterogeneity and CT noise. The results of this study indicate that CT noise introduces large errors in the derived flow value when data for a single, unprocessed voxel are used for this purpose. CT noise increases the derived flow values in a systematic way. Tissue heterogeneity results in a systematic error which lowers the derived flow values. Errors due to both parameters are computed for typical and extreme conditions.
mesh_terms: D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D006801:Humans; D014055:Tomography, Emission-Computed / Q000379:methods*; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes