Bactericidal activity against Haemophilus influenzae of cerebrospinal fluid of patients given amoxicillin-clavulanic acid.
Patients with purulent meningitis received amoxicillin-clavulanic acid (200/20 mg/kg [body weight] per day). Clavulanic acid levels in cerebrospinal fluid were less than or equal to 0.05 micrograms/ml in 5 of 18 samples and ranged from 0.1 to 0.8 micrograms/ml in the others. Of 12 cerebrospinal fluid samples tested, 10 lacked bactericidal activity in vitro against a beta-lactamase-producing strain of Haemophilus influenzae.
D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000134:cerebrospinal fluid* / Q000494:pharmacology; D002969:Clavulanic Acids / Q000134:cerebrospinal fluid* / Q000494:pharmacology; D005260:Female; D006193:Haemophilus influenzae / Q000187:drug effects*; D006801:Humans; D008297:Male; D008583:Meningitis, Haemophilus / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged
D002969:Clavulanic Acids; D000658:Amoxicillin