Atlanto-axial subluxation in patients with seronegative spondylarthritis.
Two patients with seronegative HLA-B27-connected spondylarthropathy, associated in one case with psoriasis and in the other with Reiter's disease, who had atlanto-axial subluxation (AAS) are reported. The AAS caused muscle weakness and intractable occipito-cervical pain. Both patients were treated operatively with a Gallie type C1-C2 fusion. The symptoms subsided following surgery and the patients remained free of cervical spine discomfort. The report also indicates that the rarer variants of the HLA-B27 associated chronic seronegative spondylarthropathies may cause AAS complicated by neurological symptoms and that the disorder is amenable to surgical intervention.
D000328:Adult; D001168:Arthritis / Q000150:complications* / Q000235:genetics; D016918:Arthritis, Reactive / Q000150:complications*; D001268:Atlanto-Axial Joint / Q000293:injuries*; D006680:HLA Antigens / Q000235:genetics; D015796:HLA-B27 Antigen; D006801:Humans; D004204:Joint Dislocations / Q000209:etiology* / Q000601:surgery; D008297:Male; D010148:Intractable Pain / Q000209:etiology; D011565:Psoriasis / Q000150:complications; D013122:Spinal Diseases / Q000150:complications* / Q000235:genetics
D006680:HLA Antigens; D015796:HLA-B27 Antigen