[Metabolism of vitamin A in Forestier-Rotès-Quérol hyperostosis].
High doses of retinol produce hyperostotic lesions in animals and humans. In this study we measured in fasting subjects and 5 hours after administering 50,000 IU of retinol, levels in the serum of retinol, retinol-binding protein (RBP) and prealbumin in 35 hyperostotic subjects (HVA) and 22 control subjects. Retinol levels were equally high after fasting and after consumption of vitamin A (p 0.01). The levels of retinol-binding protein and prealbumin increase in parallel, such that the molar ratios of retinol to retinol-binding protein or to prealbumin are not changed. Taken with literature data, those of the present study indicate that vitamin A is responsible for the production of hyperostotic lesions.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D004057:Hyperostosis, Diffuse Idiopathic Skeletal / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011228:Prealbumin / Q000032:analysis; D012177:Retinol-Binding Proteins / Q000032:analysis; D013128:Spinal Osteophytosis / Q000378:metabolism*; D014801:Vitamin A / Q000097:blood / Q000378:metabolism*
D011228:Prealbumin; D012177:Retinol-Binding Proteins; D014801:Vitamin A
Etude du métabolisme de la vitamine A au cours de la maladie hyperostosique de Forestier et Rotès-Quérol.