[Indices of cellular and humoral immunity in chronic myeloproliferative diseases].
The populations of lymphocytes and serum immunoglobulins were explored in 20 patients with erythremia, 26 patients with sub-leukemic myelosis, 38 patients with pronounced chronic myeloid leukemia, and 33 patients with the blastic phase of the illness. The patients with chronic myeloproliferative diseases manifested cellular immunodeficiency that was aggravated as the disease progressed. In the pronounced stage, the patients showed relative preservation of humoral immunity whereas in the terminal stage they developed humoral deficiency. Study of the time-course of changes in the immunological characteristics has demonstrated that deterioration of the characteristics starts during blast transformation of myeloproliferative diseases. This may serve as a criterion for predicting exacerbations and early diagnosis of the blastic phase.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D002908:Chronic Disease; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D007958:Leukocyte Count; D008215:Lymphocytes, Null / Q000276:immunology; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000276:immunology*; D011379:Prognosis; D013601:T-Lymphocytes / Q000276:immunology
D007136:Immunoglobulins
Pokazateli kletochnogo i gumoral'nogo immuniteta pri khronicheskikh mieloproliferativnykh zabolevaniiakh.