Idiotypes of monoclonal anti-DNA antibodies produced in autoimmune B/W mice are expressed in normal mice.
An anti-idiotypic antiserum was prepared in a rabbit immunized against a pool of six monoclonal anti-DNA antibodies generated in B/W mice. This antiserum detected idiotypic determinants in four of the six monoclonal anti-DNA antibodies but also in the serum of several non autoimmune strains (BALB/c, NZB X BALB/c) F1 hybrids & CBA/LH). The antiserum also reacted, but only to a weak degree, with B/W mouse sera. These results indicate that some idiotypes of anti-DNA antibodies produced by autoimmune B/W mice are present in normal mouse sera.
D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D001327:Autoimmune Diseases / Q000276:immunology; D004247:DNA / Q000276:immunology*; D007106:Immune Sera / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000032:analysis*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D011817:Rabbits
D000974:Antibodies, Antinuclear; D000911:Antibodies, Monoclonal; D007106:Immune Sera; D007130:Immunoglobulin Idiotypes; D004247:DNA