Role of renal nerves and dopamine on prostaglandin E release from the kidney of rats.
The aim of the study is to investigate the role of renal nerves and dopamine (DA) on urinary excretion of prostaglandin E (PGE) released from kidney with or without salt loading in rats. After excessive intake of high Na, urinary excretions of PGE and DA enhanced as compared with those of basal Na. In rats with renal denervation, urinary excretion of PGE and norepinephrine decreased in salt loading, and urinary Na excretion increased. Urinary PGE excretion was also enhanced by treatment of bromocriptine accompanying with augmented natriuresis. Urinary PGE excretion was suppressed by treatment of carbidopa, which also suppressed the urinary excretion of DA. These results suggest that the renal adrenergic nerve and tubular DA in kidney play an important role on the release of PGE and that these mechanisms in PGE release from kidney augment in salt loading.
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D002230:Carbidopa / Q000494:pharmacology; D003714:Denervation; D004298:Dopamine / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011458:Prostaglandins E / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000008:administration & dosage
D011458:Prostaglandins E; D001971:Bromocriptine; D012964:Sodium; D002230:Carbidopa; D004298:Dopamine