Corticotropin-releasing factor mRNA in the hypothalamus is affected differently by drinking saline and by dehydration.
Corticotropin-releasing factor (CRF) stimulates the synthesis and release of adrenocorticotropin in the anterior pituitary and may help maintain fluid and electrolyte balance. 'Salt-loaded' rats had an increase in CRF mRNA in hypothalamic magnocellular neurons of the paraventricular and supraoptic nuclei and a decrease in message in the parvocellular paraventricular neurons. After salt-loaded rats were adrenalectomized, CRF mRNA increased in the parvocellular cells. In contrast to salt loading, water deprivation lead to a decrease in CRF mRNA in magnocellular and parvocellular neurons. These results show that CRF synthesis within separate populations of hypothalamic neurons is regulated differently under various conditions.
D000315:Adrenalectomy; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000235:genetics*; D003681:Dehydration / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology; D014882:Water-Electrolyte Balance
D012333:RNA, Messenger; D012965:Sodium Chloride; D003346:Corticotropin-Releasing Hormone