[T- and B-components of immunity in acute altitude sickness].
Immunological aspects of the adaptation process were investigated in 57 male test subjects that stayed for 30 days at an altitude of 3600 m above sea level (Eastern Pamir Mountain Range). The uneventful development of adaptation was accompanied by a short-term decrease in the number and activity of T-lymphocytes. An acute mountain disease led to a distinct deficiency of T-cell immunity which still persisted on test day 30. Besides, the content of zero cells in circulating blood was increased and the blast-transformation reaction of lymphocytes to concanavalin A was inhibited. Prior to the ascent the test subjects who were susceptible to the acute mountain disease showed a lower content of T-lymphocytes and a higher content of zero cells in circulating blood.
D000064:Acclimatization; D000208:Acute Disease; D000532:Altitude Sickness / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D002469:Cell Separation; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D000860:Hypoxia / Q000276:immunology*; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D010835:Phytohemagglutinins; D003208:Concanavalin A
T- i B-zven'ia immuniteta pri ostroĭ gornoĭ bolezni.