title: Skeletal myoclonus in olivopontocerebellar atrophy: treatment with trihexyphenidyl.
abstract: We studied two patients with nonfamilial olivopontocerebellar atrophy with skeletal myoclonus. Palatal or skeletal myoclonus is probably not a coincidental finding but another manifestation of the underlying disease. In both cases, the myoclonus was suppressed by administration of trihexyphenidyl, indicating a cholinergic disorder.
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging; D002998:Clonazepam / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000503:physiopathology; D009207:Myoclonus / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D009849:Olivopontocerebellar Atrophies / Q000150:complications* / Q000000981:diagnostic imaging; D013132:Spinocerebellar Degenerations / Q000150:complications*; D014057:Tomography, X-Ray Computed; D014282:Trihexyphenidyl / Q000627:therapeutic use*
chemical_list: D002998:Clonazepam; D014282:Trihexyphenidyl