Effects of radioprotective glycans on the arrest of blood-borne lymphoma cells.
The mode of action of radioprotective glycans is not understood. In view of the known importance of cell migration in haematology, on the one hand, and of carbohydrates in homing processes, on the other, we have investigated the effect of several glycans on blood-borne arrest of lymphoma cells. Radioprotective glycans (but not heparin) modified the arrest of injected cells in the spleen. Altered recirculation and homing processes may play a role in the radioprotective properties of glycans.
D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D005260:Female; D007275:Injections, Intravenous; D008223:Lymphoma / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains; D009360:Neoplastic Cells, Circulating; D009928:Organ Specificity; D011134:Polysaccharides / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013601:T-Lymphocytes; D014407:Tumor Cells, Cultured
D011134:Polysaccharides; D011837:Radiation-Protective Agents