An epidermal factor which induces thyroid hormone-dependent regression of mesenchymal tissues of the tadpole tail.
Explants of tadpole tail skin secreted a factor which induces the thyroid hormone-dependent regression of the tail mesenchyme. The activity of the factor was not sensitive to digestion with trypsin or pronase. Heating at 120 degrees C but not at 100 degrees C for 20 min destroyed the activity. The factor came out gradually through a dialysis membrane. The factor was retarded on a Sephadex G-10 column and eluted with water after the salts fraction. We suggest that the active principle is a non-proteinaceous substance with a low molecular weight.
D000818:Animals; D004817:Epidermis / Q000502:physiology; D007814:Larva / Q000502:physiology; D008648:Mesoderm / Q000502:physiology; D011892:Rana catesbeiana / Q000254:growth & development*; D013623:Tail / Q000033:anatomy & histology; D014284:Triiodothyronine / Q000494:pharmacology
D014284:Triiodothyronine