Inhibitory effect of human recombinant interleukin-1 alpha and beta on growth of human vascular endothelial cells.
Endothelial cell growth factor (ECGF) is a potent polypeptide mitogen which stimulates the growth of endothelial cells. The mitogenic effect of ECGF was inhibited by addition of recombinant interleukin-1 (rIL-1) alpha or beta in a concentration dependent manner. The morphological change was not observed distinctly. In the condition without ECGF, both types of rIL-1 enhanced [3H]-thymidine uptake slightly, but failed to increase cell numbers. These data suggest the possibility that the effect of rIL-1 on EC is modulated by the presence of ECGF.
D002455:Cell Division / Q000187:drug effects; D004727:Endothelium / Q000166:cytology* / Q000187:drug effects; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism
D007375:Interleukin-1; D011994:Recombinant Proteins; D005346:Fibroblast Growth Factors; D013936:Thymidine