[Chorionic gonadotropin as a modulator of cell interaction in the induction of the primary immune response].
The authors studied the effect of chorionic gonadotropin (CG) on the formation of a primary immune response and interactions of T- and B-lymphocytes in the realization of a humoral response to sheep erythrocytes in CBA and E1 (CBA X C57BL/6) mice. CG at a dose of 40 U. significantly increased the amount of antibody forming cells (AFC) whereas at a dose of 200 U. it made no significant effect on a primary immune response. The injection of chorionic gonadotropin (40 or 200 U.) to mouse donors of T-cells did not influence their ability for cooperative interactions. At the same time administration of the hormone to donors of B-cells reduced their ability for cooperation in the system of syngeneic transfer. CG injection of lymphoid cells to recipient mice caused an increase in AFC formation and the dose of 40 U. was more effective than the dose of 200 U. Possible mechanisms of the CG effect on immunogenesis were discussed.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects*; D001402:B-Lymphocytes / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D006824:Hybridization, Genetic; D008211:Lymphocyte Cooperation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects
D006063:Chorionic Gonadotropin
Khorionicheskiĭ gonadotropin kak moduliator kletochnykh vzaimodeĭstviĭ v induktsii pervichnogo immunnogo otveta.