title: [Cross-reacting HLA-B alleles as genetic markers of HLA-B27 negative ankylosing spondylitis].
abstract: 15 east Austrian patients (EUC) with HLA-B27-negative ankylosing spondylitis (AS) were tissue-typed for HLA-B-antigens. HLA-B-alleles of the B27-CREG (B7, B13, Bw22, B40) were found in 14/15 patients (= 93,3%; RR = 37,8; Chi2 = 23,21; p less than 0.05) of this group. We may postulate a common partial-antigen for AS, carried by HLA-alleles belonging to the B27-CREG. This partial-antigen may either react in a direct pathway with the unknown pathogenic agent of AS or represent a marker for the "disease-susceptibility genes" of AS.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D005819:Genetic Markers; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D015793:HLA-B7 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D013167:Spondylitis, Ankylosing / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D006680:HLA Antigens; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D015793:HLA-B7 Antigen
vernacular_title: Kreuzreagierende HLA-B-Allele als genetische Marker der HLA-B27-negativen Spondylitis ankylosans.