title: [Morphological and immunologic changes following intratumoral administration of alpha interferon in patients with breast cancer].
abstract: Patients with early breast cancer received single intratumoral injections of 10,000, 100,000 or 200,000 IU alpha-interferon before radical surgery. Interferon was found to produce a dose-dependent cytotoxic and immune-boosting effect. A dose of 100,000 and 200,000 IU caused drug pathomorphosis in tumor and brought down immunologic indexes of peripheral blood. Administration of 10,000 IU stimulated T-cell-mediated immunity.
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D001943:Breast Neoplasms / Q000276:immunology / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage*; D008198:Lymph Nodes / Q000276:immunology; D011300:Preoperative Care; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007370:Interferon Type I
vernacular_title: Morfologicheskie i immunologicheskie izmeneniia pri vnutriopukholevom vvedenii al'fa-interferona u bol'nykh rakom molochnoĭ zhelezy.