[Comparative in vitro studies of cell-mediated immunity in chronic liver diseases].
Reactions of cell-mediated immunity are investigated in 32 healthy controls and 134 patients with chronic liver diseases (E-rosette-forming cells, lymphocyte transformation test, leucocyte migration inhibition test using the T-cell-mitogens Phytohaemagglutinin and Concanavalin A). The number of E-rosette-forming cells is significantly decreased in chronic active hepatitis, alcoholic hepatitis and cirrhosis. The 3H-thymidine uptake in the lymphocyte transformation test by use of PHA and Con A is markedly reduced especially in active and progressed liver diseases. PHA caused a significant higher inhibition of leucocyte migration in patients with alcoholic hepatitis and cirrhosis than in healthy controls. A dependency between the results of the two tests is not detectable (Chi 2-test). We found in individual cases of groups with liver diseases serum inhibition factors by MIT, but not correlations with other immunological or clinical-chemical parameters. The pathogenetical value of the used methods in cases with chronic liver diseases is questionable.
D002464:Cell Migration Inhibition; D002908:Chronic Disease; D006521:Hepatitis, Chronic / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008103:Liver Cirrhosis / Q000276:immunology; D008107:Liver Diseases / Q000276:immunology*; D008108:Liver Diseases, Alcoholic / Q000276:immunology; D008111:Liver Function Tests; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology
Vergleichende in-vitro-Untersuchungen zur zellvermittelten Immunität bei chronischen Lebererkrankungen.