title: Artificially induced developmental defects in sheep enamel examined by scanning electron microscopy.
abstract: Upper incisor teeth from sheep infected with parasites or given 6 mg fluoride per kg bodyweight for 21 days during the period of tooth formation were examined with SEM and microradiography. It was found using both techniques that there had been a severe disturbance of the secretory ameloblasts leading to enamel hypoplasia. It is suggested that it is the severity rather than the cause of the insult to the ameloblasts which determines the degree of hypoplasia.
mesh_terms: D000565:Ameloblasts / Q000187:drug effects / Q000648:ultrastructure; D000566:Amelogenesis / Q000187:drug effects; D000818:Animals; D003743:Dental Enamel / Q000648:ultrastructure; D003744:Dental Enamel Hypoplasia / Q000139:chemically induced* / Q000209:etiology / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005459:Fluorides / Q000008:administration & dosage / Q000633:toxicity*; D007180:Incisor; D008855:Microscopy, Electron, Scanning; D010272:Parasitic Diseases / Q000150:complications*; D012756:Sheep
chemical_list: D005459:Fluorides