Complement depletion suppresses Lewis rat experimental allergic neuritis.
Lewis rats immunized with myelin and complete Freund's adjuvant were treated with cobra venom factor (CVF) which depletes the C3 component of complement. CVF given at day 9 delayed the onset of experimental allergic neuritis (EAN) by 2-3 days and when given at days 9 and 12 delayed the onset of EAN by 4-5 days. Lumbar nerve roots of CVF-treated rats had significantly less demyelination than those from control EAN rats.
D000818:Animals; D003039:Cobra Neurotoxin Proteins; D003167:Complement Activation / Q000187:drug effects; D003176:Complement C3 / Q000097:blood / Q000276:immunology*; D005620:Freund's Adjuvant; D008297:Male; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology* / Q000503:physiopathology; D051381:Rats; D011917:Rats, Inbred Lew; D013126:Spinal Nerve Roots / Q000276:immunology / Q000473:pathology; D013997:Time Factors
D003039:Cobra Neurotoxin Proteins; D003176:Complement C3; D005620:Freund's Adjuvant