1-substituted 5-dialkylaminomethyl-1,5,6,7-tetrahydroindazol-4-ones with antiinflammatory and analgesic activity.
The synthesis of 1-phenyl- and 1-methyl-5-dialkylamino-methyl-1,5,6,7-tetrahydroindazol-4-ones (III) and (IV) by Mannich reaction of the corresponding 1-substituted 1,5,6,7-tetrahydroindazol-4-ones (I) and (II) is described. Some compounds (III) showed a good antiinflammatory and analgesic activity in rats and mice, respectively. Infiltration anesthesia in mice and antiacetylcholine activity in vitro are also reported.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000777:Anesthetics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007191:Indazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis*; D051381:Rats
D000777:Anesthetics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007191:Indazoles; D011720:Pyrazoles; D000109:Acetylcholine