Autoantibodies in humans with cystic or alveolar echinococcosis.
Sera from 16 echinococcosis patients were analyzed with respect to polyclonal B cell activation and autoantibody formation. At least 8 of the sera were from patients who were never in tropical countries and therefore their cases were not complicated by other parasitic diseases. In comparison with a group of 52 healthy controls, these patients had significant levels of antibodies to DNP and haemocyanin, indicators of polyclonal B cell activation. There were also significant differences between control and patient groups with respect to antibodies to dsDNA, histones, actin, vimentin, and desmin. This is the first report of autoantibodies in echinococcosis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000096:biosynthesis*; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D004140:Dinitrophenols / Q000276:immunology; D004443:Echinococcosis / Q000276:immunology*; D004445:Echinococcosis, Pulmonary / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006433:Hemocyanins / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; D004140:Dinitrophenols; D006433:Hemocyanins