[Changes in the antigenic phenotype of mouse thymocytes after exposure to chemical inducers of differentiation and ionizing radiation].
Irradiation of a mouse thymocyte fraction enriched by T-lymphocyte precursors changes the antigenic phenotype of cells toward the increase of their highly differentiated forms. Similar changes in membrane marker antigens are produced by chemical inductors of differentiation and thymotropin. The changes in the cell phenotype induced by the above agents are associated with both membrane and intragenome rearrangements. The results of the experiments on preventing the expression of some antigens by puromycin and the data on the level of spontaneous genome lesions in thymocyte fractions have prompted an assumption that destabilization of the genome upon irradiation increases DNA injury above some critical level which may serve a stimulus for "sorting out" the most radiosensitive thymocyte fraction.
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics / Q000528:radiation effects*; D002454:Cell Differentiation / Q000187:drug effects / Q000528:radiation effects*; D003601:Cytotoxicity Tests, Immunologic; D004249:DNA Damage; D006183:H-2 Antigens / Q000235:genetics / Q000528:radiation effects; D051379:Mice; D008808:Mice, Inbred CBA; D010641:Phenotype; D011691:Puromycin / Q000494:pharmacology; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*; D013947:Thymosin / Q000494:pharmacology
D000945:Antigens, Differentiation, T-Lymphocyte; D006183:H-2 Antigens; D011691:Puromycin; D013947:Thymosin
Izmenenie antigennogo fenotipa timotsitov mysheĭ pri deĭstvii khimicheskikh induktorov differentsirovki i ioniziruiushcheĭ radiatsii.