Oscillations in blood cells as a consequence of suppressed bone marrow cell production.
A hypothesis is proposed that the oscillations in blood cell numbers are the result of suppressed productivity of the bone marrow and its ability to satisfy both the demands of the erythroid and myeloid cell lines. The hypothesis is used as the basis for a mathematical model which describes the oscillations in all subpopulations of these cell lines. The relationship between the period and amplitude of the oscillations and the extent of suppression of the bone marrow productivity have been explored.
D001772:Blood Cell Count; D001773:Blood Cells / Q000166:cytology*; D001853:Bone Marrow / Q000502:physiology*; D002453:Cell Cycle; D004920:Erythropoiesis; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D008533:Megakaryocytes / Q000166:cytology; D008962:Models, Theoretical; D009504:Neutrophils / Q000502:physiology; D010507:Periodicity