The effect of intra-articular steroids on plasma salicylate concentrations.
Plasma salicylate concentrations and salicylate clearances were evaluated in 10 patients before and then 3 days after the intra-articular administration of glucocorticoid steroids. All patients were on chronic salicylate treatment, the dosage varying from 1.3-4.6 g day-1 of enteric-coated aspirin. The mean steady state plasma concentration (+/- s.e. mean) of salicylate decreased significantly after intra-articular steroid (90.9 +/- 14.8 mg l-1-64.7 +/- 8.9, P less than 0.05), whilst the mean clearance increased significantly (87.3 +/- 20.6 ml min-1-120.6 +/- 28.3, P less than 0.05). In these paired studies, the intra-articular administration of steroids lead to a significant decrease in plasma salicylate levels in patients taking enteric-coated aspirin.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001241:Aspirin / Q000097:blood* / Q000627:therapeutic use; D003907:Dexamethasone / Q000008:administration & dosage; D004347:Drug Interactions; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007270:Injections, Intra-Articular; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D012216:Rheumatic Diseases / Q000097:blood / Q000188:drug therapy; D014221:Triamcinolone / Q000008:administration & dosage
D005938:Glucocorticoids; D014221:Triamcinolone; D003907:Dexamethasone; D011239:Prednisolone; D001241:Aspirin; D008775:Methylprednisolone