Local anesthetics inhibit veratridine-induced secretion of calcitonin gene-related peptide (CGRP) from cultured rat trigeminal ganglion cells.
Secretion of calcitonin gene-related peptide (CGRP) was studied with the model system of dispersed adult rat trigeminal ganglion cells. Veratridine stimulated secretion of CGRP immunoreactivity. Tetrodotoxin and local anesthetics inhibited veratridine-stimulated peptide secretion. These observations implicate sodium channels in CGRP secretion and are consistent with a role for the peptide as an extracellular neuromodulator in the sensory nervous system.
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D002478:Cells, Cultured; D008012:Lidocaine / Q000494:pharmacology; D009479:Neuropeptides / Q000378:metabolism*; D011343:Procaine / Q000494:pharmacology; D051381:Rats; D014278:Trigeminal Nuclei / Q000187:drug effects* / Q000378:metabolism; D014701:Veratridine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014702:Veratrine / Q000031:analogs & derivatives*
D000779:Anesthetics, Local; D009479:Neuropeptides; D011343:Procaine; D014701:Veratridine; D008012:Lidocaine; D014702:Veratrine; D015740:Calcitonin Gene-Related Peptide