[Effect of anticonvulsant agents, inducers of microsomal oxidation, on the B-link of immunity and on the natural cytotoxicity of lymphoid organ cells in rats].
Administration of phenobarbital, benzonal and benzobamil in a dose of 1/20 of LD50 to rats was shown to be followed by phase changes in the system of microsomal oxidation of the liver--activation in the first days after administration with the subsequent (in 1-3 months) decrease of the activity. The drugs activate the specific link of immunity directed at detoxication of the administered substances: increase the level of specific antibody-forming cells in the spleen and antibodies in the peripheral blood. Benzonal and bezobamil enhance the killing activity of cells of the thymus, phenobarbital and benzonal suppress the natural cytotoxicity of cells of the spleen and peritoneal exudate.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D001463:Barbiturates / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010424:Pentobarbital / Q000031:analogs & derivatives / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors
D000927:Anticonvulsants; D001463:Barbiturates; C055631:benzobamil; D003577:Cytochrome P-450 Enzyme System; D010424:Pentobarbital; C002915:benzobarbital; D010634:Phenobarbital
Vliianie protivosudorozhnykh sredstv--induktorov mikrosomal'nogo okisleniia na B-zveno immuniteta i estestvennuiu tsitotoksichnost' kletok limfoidnykh organov krys.