Release of calcitonin gene-related peptide from a human medullary carcinoma of the thyroid in vitro.
The secretion of human calcitonin gene-related peptide was examined in perifusates of medullary carcinoma of the thyroid with a sensitive radioreceptor assay. Calcitonin gene-related peptide was released after the addition of calcium (25-100 mM), in a dose-dependent manner. The results indicate that human medullary carcinomas of the thyroid secrete the calcitonin gene-related peptide as well as calcitonin.
D000328:Adult; D002116:Calcitonin / Q000494:pharmacology; D015740:Calcitonin Gene-Related Peptide; D002118:Calcium / Q000494:pharmacology; D002277:Carcinoma / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011869:Radioligand Assay; D013964:Thyroid Neoplasms / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide; D002118:Calcium