Analysis of interleukin 1 mediated radioprotection.
The potential value of interleukin 1 (IL-1) containing supernatants as a radioprotective agent was evaluated. It was found that the response of irradiated thymocytes to mitogens was partially restored if IL-1 containing supernatants was included in the culture medium immediately after irradiation. A delay of 24 h in the addition of IL-1 and mitogen abrogated the radioprotection effect. Under the same conditions IL-2 containing supernatants were effective, suggesting that the dose modifying effect of IL-1 acts through induction of IL-2 elaboration. The results of the present study may be important in cases where it is necessary to restore depressed immune response resulting from irradiation accidents or radiotherapy.
D000818:Animals; D005720:Gamma Rays; D007375:Interleukin-1; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008934:Mitogens / Q000494:pharmacology; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects*; D013997:Time Factors
D007375:Interleukin-1; D007376:Interleukin-2; D008934:Mitogens; D011837:Radiation-Protective Agents