Heterochromatic variants and their association with neoplasias: III. Multiple myeloma.
The incidence of heterochromatic variants was assessed in 26 patients with multiple myeloma (MM) and 55 control individuals. An enhanced frequency of heteromorphism was present in 92% of the MM population compared with 44% of the control group (p less than 0.001). Significant differences with regard to controls were observed in chromosome pairs #1, #9, and #16 due to 1qh-, inv(1),inv(9) and 16qh- variants. We suggest that MM would present an intermediate heterochromatic behavior between hematologic diseases and solid tumors.
D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D002899:Chromosomes, Human, Pair 9; D005819:Genetic Markers; D006570:Heterochromatin / Q000235:genetics*; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics*; D011110:Polymorphism, Genetic
D005819:Genetic Markers; D006570:Heterochromatin