Anti-Thy-1 response of H-2f/H-2r heterozygotes: an unusual case of genetic control.
Anti-Thy-1 responsiveness of H-2r homozygous and H-2f/H-2r heterozygous mice was studied. Good responsiveness appeared to be independent of H-2 phenotype of responder but was influenced by the phenotype of the donor. These results were incompatible with the concept of Ir-Thy-1 genes controlling the response to cell-free Thy-1 in these mice. In contrast the results were indicative of the response to the cell-bound form of the Thy-1 antigen. It is proposed that good anti-Thy-1 response may reflect the presence of clones capable of recognizing the Thy-1 antigen in the context of or in association with incompatible class I H-2 molecules.
D000818:Animals; D005260:Female; D006183:H-2 Antigens / Q000145:classification / Q000235:genetics* / Q000276:immunology; D006579:Heterozygote; D006649:Histocompatibility Antigens / Q000235:genetics / Q000276:immunology; D007114:Immunization; D007518:Isoantibodies / Q000235:genetics* / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D013950:Thymus Gland / Q000166:cytology
D006183:H-2 Antigens; D006649:Histocompatibility Antigens; D007518:Isoantibodies; C035678:anti-Thy antibody