title: Tics in a patient with Parkinson's disease.
abstract: A patient with Gilles de la Tourette syndrome later developed Parkinson's disease in middle age. This was accompanied by a marked reduction in the frequency of tics but levodopa toxicity exacerbated the tics. The dopamine hypothesis of tic disorders is supported by this observation.
mesh_terms: D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D011954:Receptors, Dopamine / Q000502:physiology; D005879:Tourette Syndrome / Q000139:chemically induced / Q000150:complications* / Q000503:physiopathology
chemical_list: D011954:Receptors, Dopamine; D007980:Levodopa