title: A cDNA encoding the precursor of the rat neuropeptide, neurokinin B.
abstract: We have isolated a cDNA clone from a rat cerebral cortex library which encodes the 116 amino acid precursor of the neuropeptide, neurokinin B. The precursor has 68% amino acid homology to the bovine precursor and encodes a single peptide of the tachykinin family. Except for possible small variations at both ends of the message, there appears to be only a single species of neurokinin B mRNA in rat cerebral cortex. In situ hybridization histochemistry indicates that the message is widely distributed in the rat brain in a pattern distinct from that of substance P message.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002540:Cerebral Cortex / Q000032:analysis* / Q000378:metabolism; D004247:DNA / Q000032:analysis*; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D015287:Neurokinin B; D009479:Neuropeptides / Q000235:genetics* / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D011498:Protein Precursors / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis* / Q000378:metabolism; D051381:Rats; D012689:Sequence Homology, Nucleic Acid
chemical_list: D009479:Neuropeptides; D011498:Protein Precursors; D012333:RNA, Messenger; D015287:Neurokinin B; D004247:DNA