[Action of cyclophosphane and degranol on the T- and B-lymphocyte populations in the lymph nodes when administered endolymphatically].
Experiments on rats demonstrated that endolymphatic administration of high doses of cyclophosphane and degranol produces prolonged but reversible decrease of relative content of T- and B-lymphocytes both in the regional and remote lymph nodes. In early periods after lymphatic infusion there was observed the predominant action of degranol on T-lymphocytes and that of cyclophosphane on B-lymphocytes. Differences in the character of changes in primary immune response magnitude after administration of the drugs are related probably to their diverse effects on different subpopulations of lymphocytes.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D003520:Cyclophosphamide / Q000494:pharmacology*; D007272:Injections, Intralymphatic; D007958:Leukocyte Count / Q000187:drug effects; D008198:Lymph Nodes / Q000187:drug effects* / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008357:Mannomustine / Q000494:pharmacology*; D051381:Rats; D012397:Rosette Formation; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors
D003520:Cyclophosphamide; D008357:Mannomustine
Deĭstvie tsiklofosfana i degranola na populiatsii T- i B-limfotsitov v limfaticheskikh uzlakh pri éndolimfaticheskom vvedenii preparatov.