Sera of patients with idiopathic myxedema contain IgG which block TSH-stimulated thyroid adenylate cyclase.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D002460:Cell Line; D006801:Humans; D007037:Hypothyroidism / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology / Q000302:isolation & purification*; D009230:Myxedema / Q000209:etiology / Q000276:immunology*; D013961:Thyroid Gland / Q000201:enzymology*; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000276:immunology; D013972:Thyrotropin / Q000494:pharmacology*
D007074:Immunoglobulin G; D013972:Thyrotropin; D000262:Adenylyl Cyclases