title: Interleukin-1-like activity in human cerebrospinal fluid.
abstract: Cerebrospinal fluid (CSF) samples were obtained from patients undergoing myelography, who were subsequently diagnosed as having degenerative neck or back disease with no significant CNS inflammation. Using a mitogen co-stimulation assay with mouse thymocytes, or interleukin-1 (IL1) dependent interleukin-2 (IL2) secreting tumour cell line, these CSF samples were shown to contain an IL1-like activity, with predominant activity located in molecules with size 15 kDa and 30 kDa (Sephadex size chromatography). The results are discussed in light of data implicating a role for IL1 in other physiological functions.
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000134:cerebrospinal fluid*; D008213:Lymphocyte Activation; D051379:Mice; D008809:Mice, Inbred C3H; D013601:T-Lymphocytes / Q000032:analysis
chemical_list: D007375:Interleukin-1