The inhibitory effect of succinate on radiation-enhanced mitochondrial lipid peroxidation.
The degree of mitochondrial ADP/Fe/NADPH-induced lipid peroxidation was increased up to the fourth day after 9.0 Gy whole body gamma-irradiation. The lipid peroxidation inhibiting effect of succinate added to isolated mitochondria was diminished as a consequence of irradiation. The succinate, administered in vivo prior to irradiation, decreased the amount of malondialdehyde production and protected the succinate dehydrogenase enzyme against inactivation. The mean survival of succinate-pretreated animals was much longer than that of controls. The role of mitochondrial lipid peroxidation in the pathogenesis of radiation injury is discussed.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D005720:Gamma Rays; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000096:biosynthesis; D008930:Mitochondria, Liver / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D011837:Radiation-Protective Agents; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013386:Succinates / Q000494:pharmacology*
D008054:Lipid Peroxides; D011837:Radiation-Protective Agents; D013386:Succinates; D009243:NAD; D008315:Malondialdehyde; D000244:Adenosine Diphosphate; D013385:Succinate Dehydrogenase