Relationships between non organ-specific autoantibody production and age-related modifications of mononuclear cell phenotype.
13 autoantibodies were sought in 23-26 elderly people and in 47-118 young controls. We found at least one autoantibody (mainly rheumatoid factor, RF, and anti-nuclear antibodies in 17/23 elderly (i.e., 17%) and in 7/45 young controls (i.e., 16%). Autologous rosette-forming cells and Leu-7 positive cells (Natural Killer Cells?) were higher, and OKT4 and OKT8 positive cells lower in the former than in the latter group. We show that elderly have a high proportion of CD5 positive B cells, compared with young controls, following phorbol myristic acetate activation in vitro. This abnormality might account for the discrepancy in production of RF compared to other autoantibodies.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D001402:B-Lymphocytes / Q000145:classification / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000145:classification / Q000276:immunology*; D008875:Middle Aged; D009928:Organ Specificity; D010641:Phenotype; D012217:Rheumatoid Factor / Q000378:metabolism; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D001323:Autoantibodies; D012217:Rheumatoid Factor; D013755:Tetradecanoylphorbol Acetate