Gas chromatographic-mass spectroscopic characterisation of the psychotomimetic indolealkylamines and their in vivo metabolites.
The use of liquid chromatography with on-line fluorescence detection has formed the basis for the separation, characterisation and quantitation of a number of metabolites of the psychotomimetic indolealkylamines N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine formed both in vitro and in vivo. Verification of the identity of metabolites has previously been facilitated by the combined use of a number of analytical techniques including multidimensional liquid chromatography and stop-flow spectroscopic analysis. We now describe the combination of liquid chromatography with gas chromatography-mass spectrometry for the unequivocal verification of a number of structurally characteristic metabolites of the psychotomimetic indolealkylamines.
D000818:Animals; D002027:Bufotenin / Q000652:urine; D002853:Chromatography, Liquid; D008401:Gas Chromatography-Mass Spectrometry; D006213:Hallucinogens / Q000652:urine*; D008297:Male; D008732:Methoxydimethyltryptamines / Q000652:urine; D004130:N,N-Dimethyltryptamine / Q000652:urine*; D010087:Oxides / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D014297:Trimethylsilyl Compounds / Q000032:analysis; D014363:Tryptamines / Q000652:urine*
D006213:Hallucinogens; D008732:Methoxydimethyltryptamines; D010087:Oxides; D014297:Trimethylsilyl Compounds; D014363:Tryptamines; D002027:Bufotenin; D004130:N,N-Dimethyltryptamine