[Effect of biseptol on the adrenal cortex of the white rat in postoperative shock].
The study aimed to find out the effect of sulfonamide combined with Trimetaprim-Biseptol 480 on the adrenal cortex in post-operative shock after removal of SPIGELian lobe (lobectomy of the lobus caudatus and unilaterally of one kidney with its suprarenal gland. The study was performed on a material of white rats which were post-operatively administered Biseptol 480 in doses 5 times bigger than those given to men. It was attempted to determine histochemically the intensity of the adrenal cortex' function by testing the number of lipid droplets, activity of the main enzyme of steroidogenesis (beta-hydroxy steroid dehydrogenase) and the level of alpha-ketols (as the final stage of steroidogenesis). Pathomorphologic examinations were also performe. On the basis of the present study's results, it was observed that - in the case of liver-lobectomy - the zona fasciculata and zona reticularis are functionally stimulated but the zona glomerulosa becomes insufficient. In the case of nephrectomy plus suprarenal gland's removal, all the adrenal cortex becomes insufficient. Administration of Biseptol in the 1st case contributed to hormonal inactivation of the zone glomerulosa cells, but in the 2nd case, it caused an increased activity of steroid dehydrogenase and an increase of the alpha-ketol level in the zona fasciculata.
D000302:Adrenal Cortex / Q000187:drug effects* / Q000473:pathology; D000309:Adrenal Insufficiency / Q000139:chemically induced* / Q000473:pathology; D000315:Adrenalectomy; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use / Q000633:toxicity*; D004338:Drug Combinations / Q000627:therapeutic use / Q000633:toxicity; D006498:Hepatectomy; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism; D007664:Ketosteroids / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D009392:Nephrectomy; D051381:Rats; D012773:Shock, Surgical / Q000188:drug therapy* / Q000473:pathology; D013420:Sulfamethoxazole / Q000627:therapeutic use / Q000633:toxicity*; D014295:Trimethoprim / Q000627:therapeutic use / Q000633:toxicity*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000890:Anti-Infective Agents; D004338:Drug Combinations; D007664:Ketosteroids; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D006913:Hydroxysteroid Dehydrogenases; D013420:Sulfamethoxazole
Der Einfluss von Biseptol auf die Nebennierenrinde der weissen Ratte im postoperativen Schock.