Immune response by biological response modifiers.
Several biological response modifiers (BRMs) were demonstrated to increase myelopoiesis and effector cell responses (M phi and natural killer cell activity) in vivo. The increased myelopoiesis was reflected by an increase in bone marrow cellularity and granulocyte-M phi colony-forming cells (GM-CFU-C). The increase in myelopoiesis appeared to be related to a concomitant increase in colony-stimulated factor (CSF) production and secretion by M phi and bone marrow cells. CSF induction by BRMs increased myelopoiesis and counteracted the myelosuppressive and immunosuppressive effects of cyclophosphamide. CSF induced in vivo by BRMs attained high titers and were maintained over a longer period than exogenously injected CSF, which was rapidly cleared from serum.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000380:Agranulocytosis / Q000517:prevention & control; D000818:Animals; D001388:Aziridines / Q000494:pharmacology; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology / Q000031:analogs & derivatives; D002460:Cell Line; D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors / Q000096:biosynthesis / Q000097:blood; D003520:Cyclophosphamide / Q000009:adverse effects; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006098:Granulocytes / Q000187:drug effects* / Q000276:immunology; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010844:Picibanil / Q000494:pharmacology; D011070:Poly I-C / Q000494:pharmacology; D011107:Polylysine / Q000494:pharmacology / Q000031:analogs & derivatives; D011713:Pyran Copolymer / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D001388:Aziridines; D003115:Colony-Stimulating Factors; D011107:Polylysine; D011713:Pyran Copolymer; D010844:Picibanil; C019531:poly ICLC; D003520:Cyclophosphamide; D002266:Carboxymethylcellulose Sodium; D011070:Poly I-C