Anti-inflammatory effects of synthetic retinoids may be related to their immunomodulatory action.
The effects of retinoids have been studied in a model of delayed-type hypersensitivity using the T-cell-dependent antigen, methylated bovine serum albumin to elicit inflammation in the hind paws of mice. A number of synthetic retinoids, including etretinate and arotinoids, showed a marked anti-inflammatory action in this model. Using differential dosing schedules, the anti-inflammatory effect of retinoids was clearly distinguished from conventional cyclooxygenase inhibitors. By screening a number of synthetic retinoids, structure-activity relationships for this effect can be deduced.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001565:Benzoates / Q000627:therapeutic use*; D055598:Chemical Phenomena; D002621:Chemistry; D015232:Dinoprostone; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000188:drug therapy*; D007375:Interleukin-1 / Q000494:pharmacology; D051379:Mice; D011458:Prostaglandins E / Q000096:biosynthesis; D012176:Retinoids / Q000627:therapeutic use*; D012710:Serum Albumin, Bovine
D000893:Anti-Inflammatory Agents; D001565:Benzoates; D007375:Interleukin-1; D011458:Prostaglandins E; D012176:Retinoids; D012710:Serum Albumin, Bovine; C038864:4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid; D015232:Dinoprostone