title: Oral complications of high-dose melphalan in multiple myeloma.
abstract: Four patients with multiple myeloma refractory to conventional chemotherapy received high-dose melphalan. All experienced multiple oral complications. Extensive neutropenic ulceration and orofacial herpes simplex virus infection caused considerable morbidity in three patients during prolonged periods of neutropenia.
mesh_terms: D000328:Adult; D005260:Female; D006561:Herpes Simplex / Q000209:etiology; D006801:Humans; D008297:Male; D008558:Melphalan / Q000009:adverse effects*; D008875:Middle Aged; D009059:Mouth Diseases / Q000139:chemically induced*; D009101:Multiple Myeloma / Q000188:drug therapy*; D009503:Neutropenia / Q000139:chemically induced; D009894:Opportunistic Infections; D013283:Stomatitis, Herpetic / Q000209:etiology; D014456:Ulcer / Q000139:chemically induced
chemical_list: D008558:Melphalan