A major factor contributing to epidermal proliferation in inflammatory skin diseases appears to be interleukin 1 or a related protein.
Human peripheral blood leukocytes can stimulate G1(G0)-arrested mouse skin keratinocytes to enter the cell cycle again and synthesize DNA at the maximum rate 15-20 hr later. This growth-promoting activity is released by the monocyte fraction and is shown to have characteristics that have been reported for interleukin 1 (IL-1). Pure IL-1 is active in stimulating keratinocyte cultures as was shown with recombinant human IL-1. An IL-1-like protein released by monocytes-macrophages could explain the hyperproliferative epidermis found in certain types of inflammatory skin diseases.
D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D004261:DNA Replication / Q000187:drug effects; D000078404:Epidermal Cells; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D007249:Inflammation; D007375:Interleukin-1 / Q000502:physiology*; D007399:Interphase; D007962:Leukocytes / Q000166:cytology; D008214:Lymphocytes / Q000166:cytology; D051379:Mice; D008809:Mice, Inbred C3H; D009132:Muscles / Q000166:cytology; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology*
D007375:Interleukin-1; D003208:Concanavalin A; D004815:Epidermal Growth Factor