Pregnancy after tubo-ovarian transplantation.
A rat model was developed for microsurgical en bloc vascularized adnexal isografts and allografts. Transplantation of the fallopian tube and ovary from donors to syngeneic, bilaterally tubo-oophorectomized recipients was technically successful in six of eight animals, and four litters of healthy offspring were delivered at 44, 45, 85, and 105 days after transplantation. Twelve tubo-ovarian allografts using cyclosporine for immunosuppression resulted in seven viable grafts and three pregnancies. Cyclosporine at 15 mg/kg/day was found to be teratogenic, but normal progeny were delivered when the dose was lowered to 5 mg/kg/day during pregnancy. These results suggest that microsurgical tubal transplantation with an appropriate immunosuppressive regimen warrants further investigation as potential treatment for certain infertility problems in the human.
D000818:Animals; D005187:Fallopian Tubes / Q000473:pathology / Q000637:transplantation*; D005260:Female; D006087:Graft vs Host Reaction; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007247:Infertility, Female / Q000473:pathology / Q000601:surgery; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008866:Microsurgery; D010053:Ovary / Q000473:pathology / Q000637:transplantation*; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D014185:Transplantation, Isogeneic
D007166:Immunosuppressive Agents