[M-cholinergic receptors of B-lymphocytes during immune response in mice].
The number of M-cholinergic receptors on spleen B-lymphocytes of CBA mice was determined using radioactive blocker 3H-Quinuclidinil benzilate. 3 and 4 days after the animals' immunization with ovalbumin the number of M-cholinergic receptors somewhat increased. Specific antigen attenuated M-cholinergic receptor expression on B-lymphocytes, most pronounced on day 4 after immunization, without affecting the receptor expression in control animals. Possible steric interaction between antigen-binding immunoglobulins and B-lymphocyte M-cholinergic receptors during immune response is suggested.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D001667:Binding, Competitive; D005260:Female; D007114:Immunization; D051379:Mice; D008808:Mice, Inbred CBA; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D011947:Receptors, Antigen, B-Cell / Q000276:immunology / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000276:immunology / Q000378:metabolism*
D011947:Receptors, Antigen, B-Cell; D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate
M-kholinergicheskie retseptory B-limfotsitov mysheĭ v protsesse immunnogo otveta.