Intracellular accumulation of T-cell receptor complex molecules in a human T-cell line.
This work was aimed at understanding the mechanisms of T-lymphocyte function by studying the cellular distribution and traffic of molecules of the T-cell receptor complex. The accumulation of specific molecules in intracytoplasmic vesicles is related to the activation of T lymphocytes. Some of these molecules include acid hydrolases, the transferrin receptor, and class I antigens of the major histocompatibility complex. Molecules of the T-cell receptor complex have now also been found in intracytoplasmic vesicles in a human T-cell line derived from a lymphoblastic leukemia. Such vesicles were tightly associated with the cytoplasmic microtubule network. One functional aspect of this association is a cellular pathway by which vesicles traveling to and from the cell surface converge in an area of the cells that is rich in processing enzymes.
D000911:Antibodies, Monoclonal; D002451:Cell Compartmentation; D002460:Cell Line; D003594:Cytoplasmic Granules / Q000378:metabolism; D006680:HLA Antigens / Q000378:metabolism; D006801:Humans; D008870:Microtubules / Q000648:ultrastructure; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D011990:Receptors, Transferrin / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D006680:HLA Antigens; D011948:Receptors, Antigen, T-Cell; D011990:Receptors, Transferrin