Effect of different treatments of the endotoxin-induced modifications in serum iron levels.
The effects of hyperthermia, injection of endotoxin and different antipyretics on serum iron levels in rabbits have been determined. Three antipyretics, Ketoprofen (K), Indomethacin (I), and Polymyxin B (P) induced a rise in serum iron concentration. The rise in serum levels induced by Ketoprofen seems to be related to the half life of the compound. Pretreatment with these antipyretics inhibits the rise in body temperature and the fall in serum concentration observed after the administration of bacterial endotoxin. The hyperthermia failed to modify serum iron levels.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004731:Endotoxins / Q000633:toxicity*; D005260:Female; D005334:Fever / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D007213:Indomethacin / Q000494:pharmacology; D007501:Iron / Q000097:blood*; D007660:Ketoprofen / Q000494:pharmacology; D008297:Male; D011112:Polymyxin B / Q000494:pharmacology; D011817:Rabbits
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004731:Endotoxins; D007660:Ketoprofen; D007501:Iron; D011112:Polymyxin B; D007213:Indomethacin