A long-term prospective clinical study of oral complications during conventional chemotherapy for acute leukemia.
Oral complications were detected during 89% of hospital admissions for treatment of acute leukemia in adults. Changes that reflected the underlying myelosuppression and general immunosuppression predominated. Hemorrhagic phenomena (77%), neutropenic ulceration (49%), and herpes simplex virus infections (39%) were the most common.
D000208:Acute Disease; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001424:Bacterial Infections / Q000209:etiology; D002180:Candidiasis, Oral / Q000209:etiology; D006801:Humans; D007108:Immune Tolerance; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D009059:Mouth Diseases / Q000139:chemically induced / Q000209:etiology*; D006472:Oral Hemorrhage / Q000209:etiology; D011446:Prospective Studies; D013280:Stomatitis / Q000209:etiology; D013283:Stomatitis, Herpetic / Q000209:etiology; D014456:Ulcer / Q000139:chemically induced