[Effect of the components of electro-drug anesthesia and ataralgesia on the appearance of hepato-specific enzymes in the blood].
The influence of diazepam, droperidol, fentanyl and central transcutaneous electrical stimulation (ES) on hepatocytes was studied in experiments on healthy rats (group I). Organospecific enzymes (histidase and urokinase) were chosen for the evaluation of side effects of drugs and their combination with ES on physiological functions of the liver. Drugs and their combinations with ES used in the clinical practice caused no marked damage of hepatocytes in healthy animals. A pronounced decrease in the above enzyme activity (3-fold, as compared to the control group) was revealed in rats with acute cholestasis and pancreatitis 72 h after ES. This fact shows hepatoprotective effects of ES. The most marked unfavourable effect on hepatocytes was registered in group II, where fentanyl was used.
D000818:Animals; D003975:Diazepam / Q000009:adverse effects*; D004329:Droperidol / Q000009:adverse effects*; D004599:Electric Stimulation Therapy / Q000009:adverse effects*; D005283:Fentanyl / Q000009:adverse effects*; D006638:Histidine Ammonia-Lyase / Q000097:blood; D008099:Liver / Q000187:drug effects*; D008297:Male; D051381:Rats; D004561:Transcutaneous Electric Nerve Stimulation / Q000009:adverse effects*; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood
D014568:Urokinase-Type Plasminogen Activator; D006638:Histidine Ammonia-Lyase; D004329:Droperidol; D003975:Diazepam; D005283:Fentanyl
Izuchenie vliianiia komponentov élektromedikamentoznoĭ anestezii i ataralgezii na poiavlenie v krovi gepatospetsificheskikh fermentov.