Hematological advantage of a membrane oxygenator over a bubble oxygenator in long perfusions.
To determine whether the large volumes of cardiotomy suction which occur during long perfusions can obscure the hematological advantage of the membrane oxygenator (MO) over the bubble oxygenator (BO), we studied 23 patients undergoing a coronary artery bypass grafting operation with an expected perfusion time of 3 hours (MO group, N = 10, SciMed spiral coil; BO group, N = 13, Shiley 100-A). During MO perfusion we found significantly higher platelet numbers, better platelet function (adenosine diphosphate-induced platelet aggregation), and less hemolysis (plasma hemoglobin), than during the BO perfusion. After the MO perfusion we measured significantly shorter bleeding times (Simplate II) and fewer transfusions of blood products. However, blood loss and whole-blood transfusions 18 hours after perfusion did not differ significantly between both groups. So in coronary artery bypass grafting operations with long perfusion times (mean, 3 hours), the MO still causes significantly less platelet and erythrocyte damage than the BO, despite the large volumes of cardiotomy suction known to occur during these operations.
D001026:Coronary Artery Bypass / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D008875:Middle Aged; D010106:Oxygenators; D010976:Platelet Count; D013396:Suction