title: Testosterone-induced plasticity of synaptic inputs to adult mammalian motoneurons.
abstract: The effects of testosterone administration on penile reflexes, and on the motoneurons of the spinal nucleus of the bulbocavernosus which innervate perineal muscles involved in these reflexes, were investigated in castrated male rats. Penile reflexes were restored following 48 h of testosterone administration initiated 6 weeks after castration. The amount of synaptic input to the identified motoneurons was increased following short term testosterone treatment, compared to that seen in animals receiving no testosterone, albeit to a lesser extent than that seen in animals receiving long term testosterone treatment. This increase in synaptic inputs in the short term testosterone group occurred despite the lack of an increase in somatic area. Thus, plasticity of the synaptic input to these neurons, as well as recovery of penile reflexes, occurred as a result of alterations in the hormonal state of the animal, and such changes occurred relatively rapidly.
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D008297:Male; D009046:Motor Neurons / Q000187:drug effects* / Q000648:ultrastructure; D009473:Neuronal Plasticity / Q000187:drug effects*; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D009919:Orchiectomy; D010413:Penis / Q000187:drug effects; D051381:Rats; D011917:Rats, Inbred Lew; D012018:Reflex / Q000187:drug effects; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D013569:Synapses / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone