Association between HLA-DR4 and production of collagen-specific antibodies in Israeli patients with rheumatoid arthritis.
Antibodies to native human Type I + III collagen were measured by a radioimmunoassay in sera samples of 42 rheumatoid arthritis (RA) patients. Sixteen patients (38%) had significant antibody titers. Although the frequency of HLA-DR antigens of RA patients did not differ from that of the random Israeli population, there was a significant association (P less than 0.01) between the presence of collagen antibodies and HLA-DR4.
D000328:Adult; D000368:Aged; D000918:Antibody Specificity; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001323:Autoantibodies / Q000096:biosynthesis*; D003094:Collagen / Q000276:immunology*; D005260:Female; D006681:HLA-D Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D015804:HLA-DR4 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D001323:Autoantibodies; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; D003094:Collagen