Imipramine administered during an infantile period modifies sex difference in L-5-hydroxytryptophan-induced head shakes in rats.
Five mg/kg imipramine or desipramine was injected to infantile rats. L-5-Hydroxytryptophan-induced head shakes were assessed when rats were mature. The saline- and desipramine-treated adult male rats exhibited more sustained response to L-5-HTP than females. The time course of the head shake frequency in the imipramine-treated male and female rats showed a pattern between control males and females, resulting in no significant sex difference. The results suggest that infantile exposure to imipramine induces an alteration of the serotonergic neurons of the brain.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002230:Carbidopa / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D006916:5-Hydroxytryptophan; D002230:Carbidopa; D007099:Imipramine; D003891:Desipramine