Functional characteristics of intraepithelial lymphocytes from mouse small intestine. III. Inability of intraepithelial lymphocytes to induce a systemic graft-versus-host reaction is because of failure to migrate in vivo.
In this study we have investigated whether addition of bone marrow accessory cells or concurrent administration of recombinant IL-2 would allow intraepithelial lymphocytes (IEL) to induce a systemic, lethal GvHR in irradiated hosts. In addition we have studied the ability of IEL to migrate into lymphoid tissues after intravenous injection and compared this with their locomotor capacity in vitro.
D000818:Animals; D001854:Bone Marrow Cells; D002465:Cell Movement / Q000187:drug effects; D003094:Collagen; D004847:Epithelial Cells; D005260:Female; D005782:Gels; D006087:Graft vs Host Reaction / Q000187:drug effects; D007376:Interleukin-2 / Q000494:pharmacology; D007421:Intestine, Small / Q000166:cytology / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014018:Tissue Distribution
D005782:Gels; D007376:Interleukin-2; D003094:Collagen