Transfer of beta-lactamase-associated cefoxitin resistance in Bacteroides fragilis.
A cefoxitin-resistant Bacteroides fragilis isolate, TAL 4170, which inactivates cefoxitin, was able to transfer beta-lactamase-mediated cefoxitin resistance to a susceptible B. fragilis recipient. Cefoxitin-resistant transconjugants acquired a new beta-lactamase with a pI of 8.1 and were able to inactivate cefoxitin and retransfer cefoxitin resistance. No plasmids were detected in the donor or transconjugants.
D000667:Ampicillin / Q000494:pharmacology; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D002440:Cefoxitin / Q000494:pharmacology*; D007525:Isoelectric Focusing; D010403:Penicillin Resistance; D001618:beta-Lactamases / Q000378:metabolism*
D002440:Cefoxitin; D000667:Ampicillin; D001618:beta-Lactamases