Effect of fibrin sealant on the tensile strength of rat visceral pleura.
Post mortem studies of rat lungs showed that application of fibrin sealant augments the tensile strength of the lung/visceral pleura by approximately 100 mmHg, thus impeding air leakage.
D000336:Aerosols; D000818:Animals; D004338:Drug Combinations / Q000008:administration & dosage / Q000494:pharmacology; D005176:Factor XIII / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000008:administration & dosage / Q000494:pharmacology*; D005353:Fibronectins / Q000008:administration & dosage / Q000494:pharmacology*; D006490:Hemostatics / Q000008:administration & dosage / Q000494:pharmacology*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D010994:Pleura / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013718:Tensile Strength / Q000187:drug effects*; D013917:Thrombin / Q000008:administration & dosage / Q000494:pharmacology*
D000336:Aerosols; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D005353:Fibronectins; D006490:Hemostatics; D005340:Fibrinogen; D005176:Factor XIII; D013917:Thrombin