Apolipoprotein E polymorphism, serum lipids and occurrence of "double pre-betalipoproteinemia' (DPBL) in subjects from two different populations.
The association between apolipoprotein E phenotype and the presence of 2 electrophoretic populations of very low density (VLDL) lipoproteins from human sera, double pre-beta(VLDL)lipoproteinemia (DPBL), was studied in 2 groups of subjects, one from Italy and one from Finland. In both populations the prevalence of DPBL was significantly higher in subjects with E4/4 and E4/3 phenotypes than in the other phenotypes not containing the E4 isoprotein. This finding suggests that the presence of a structural variant of the apo E protein, the isoprotein E4, may be causally related to the appearance of DPBL phenomenon.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001057:Apolipoproteins E / Q000097:blood* / Q000235:genetics; D002648:Child; D003430:Cross-Sectional Studies; D004587:Electrophoresis, Agar Gel; D005260:Female; D005387:Finland; D005828:Genetics, Population; D006801:Humans; D006951:Hyperlipoproteinemias / Q000235:genetics*; D007558:Italy; D008055:Lipids / Q000097:blood* / Q000235:genetics; D008079:Lipoproteins, VLDL / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E; D008055:Lipids; D008079:Lipoproteins, VLDL