title: DQ beta sequences in HLA-DR4 haplotypes.
abstract: A cDNA clone encoding the entire mature DQ beta chain was isolated and sequenced from the DR4-Dw14 homozygous cell line, LS40. The sequence was compared with published DQ beta sequences from cells expressing DR4-DQw3, and found to be identical. The lack of DQ beta sequence polymorphism within this serotype (to date, DQ beta sequences have been derived from five cell lines comprising three Dw subtypes) adds to the data that suggest a recent evolutionary divergence of Dw subtypes within DR4-DQw3.
mesh_terms: D001483:Base Sequence; D002460:Cell Line; D004247:DNA; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D015804:HLA-DR4 Antigen; D006239:Haplotypes; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; D004247:DNA