Hyaluronic acid is an endogenous inducer of interleukin-1 production by human monocytes and rabbit macrophages.
When human peripheral monocytes and rabbit peritoneal macrophages were incubated with hyaluronic acid, the media were found to contain interleukin-1 (IL-1) activity and to stimulate collagenase production by rabbit fibroblasts. A digestion of hyaluronic acid by testicular hyaluronidase decreased the IL-1 inducing activity. Polymixin B, an inhibitor of endotoxin, did not exert any effect towards the action of hyaluronic acid. Hyaluronic acid also stimulated human polymorphonuclear leucocytes to produce IL-1 like activity. These results indicate that hyaluronic acid is an endogenous IL-1 inducer and may play important roles in the pathological and/or physiological changes of connective tissues.
D000818:Animals; D006025:Glycosaminoglycans / Q000494:pharmacology; D006801:Humans; D006820:Hyaluronic Acid / Q000502:physiology*; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis*; D008264:Macrophages / Q000378:metabolism*; D009000:Monocytes / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism; D011817:Rabbits
D006025:Glycosaminoglycans; D007375:Interleukin-1; D006820:Hyaluronic Acid