Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region.
A domain in the low-density lipoprotein receptor contains three cysteine-rich 'growth factor' repeats like those that occur in many proteins. When this domain is deleted, the receptor no longer releases its ligand at acid pH, it is no longer recycled efficiently and it is rapidly degraded after ligand binding.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002872:Chromosome Deletion; D006224:Cricetinae; D003412:Cricetulus; D003545:Cysteine / Q000032:analysis; D004815:Epidermal Growth Factor / Q000032:analysis* / Q000235:genetics; D006863:Hydrogen-Ion Concentration; D008077:Lipoproteins, LDL / Q000378:metabolism; D008079:Lipoproteins, VLDL / Q000378:metabolism; D010957:Plasmids; D011498:Protein Precursors / Q000032:analysis* / Q000235:genetics; D011973:Receptors, LDL / Q000235:genetics / Q000502:physiology*; D012091:Repetitive Sequences, Nucleic Acid; D013329:Structure-Activity Relationship
D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D011498:Protein Precursors; D011973:Receptors, LDL; D004815:Epidermal Growth Factor; D003545:Cysteine