title: Hypothyroidism as a correlate of lateral ventricular enlargement in manic-depressive and neurotic illness.
abstract: Lateral ventricular size, as assessed by computed tomography, was not significantly greater in manic-depressive cases than in neurotic patients, but 19% of manic-depressive cases had ventricular brain ratios (VBR) more than two standard deviations above the neurotic mean. Few correlates of VBR were found in the features of the illness and the treatment given, apart from the fact that in the outpatient sample, there was a significant association between increased VBR and hypothyroidism. Hypothyroidism was relatively common in this sample, but was treated and not associated with cognitive impairment. There was no relationship between lithium administration and VBR.
mesh_terms: D000368:Aged; D000886:Anthropometry; D001714:Bipolar Disorder / Q000150:complications* / Q000188:drug therapy; D001921:Brain / Q000000981:diagnostic imaging; D014695:Cerebral Ventriculography; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications*; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009497:Neurotic Disorders / Q000150:complications* / Q000188:drug therapy; D012559:Schizophrenia / Q000150:complications; D014057:Tomography, X-Ray Computed
chemical_list: D008094:Lithium