Sacroiliitis in juvenile chronic arthritis. A 10-year follow-up.
66 children with early juvenile chronic arthritis underwent HLA A and B typing in 1974; 16 carried HLA B27. Ten of these had a pauciarticular onset, 3 systemic and 3 poly-articular. At follow-up 10 years later bilateral sacroiliitis had developed in 9 of the 16 B27 positive children, all of whom had a pauciarticular onset. Males predominated and these children had an older age of onset and a predominantly lower limb arthropathy. Enthesopathy and acute iritis further distinguished this group clinically. Other sacroiliac changes, usually simple fusion associated with severe hip involvement, were seen in 7 of the patients, 6 were girls and 6 were HLA B27 negative. Back pain and limitation had developed in 5 children, 4 of whom were B27 positive, after an average of 8 years' disease and at a mean age of 17.3 years. It is concluded that the presence of HLA B27 in boys aged 9 or over, with an onset of pauciarticular disease, signifies that they belong to the spondylitic group.
D001171:Arthritis, Juvenile / Q000150:complications* / Q000276:immunology; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006680:HLA Antigens / Q000032:analysis; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D011859:Radiography; D012446:Sacroiliac Joint / Q000000981:diagnostic imaging; D013167:Spondylitis, Ankylosing / Q000000981:diagnostic imaging / Q000209:etiology* / Q000276:immunology
D006680:HLA Antigens; D015796:HLA-B27 Antigen