Single dose of ornidazole in the treatment of bacterial vaginosis.
Bacterial vaginosis is the most common cause of excessive and foul smelling vaginal discharge. In the group of 24 women, the diagnosis was based on increased vaginal discharge, positive KOH-test, and detection of clue cells in the wet smear. In the microbiological isolation, Gardnerella vaginalis was also observed in 20 subjects and mixed anaerobic flora in all the 24 subjects. A single dose of 1.5 g of ornidazole was given. Posttreatment control was performed 7 to 28 days later. Gardnerella vaginalis was present in 2 (cure rate 90%) and anaerobes in 4 subjects (cure rate 83%). Subjective improvement occurred in 96% of patients. Side effects, the most common of them being dizziness, after ornidazole treatment were observed by 17 (71%) of subjects.
D000328:Adult; D001421:Bacteria, Anaerobic / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy*; D005260:Female; D006194:Gardnerella vaginalis / Q000302:isolation & purification; D006192:Haemophilus Infections / Q000188:drug therapy*; D006801:Humans; D009593:Nitroimidazoles / Q000627:therapeutic use*; D009950:Ornidazole / Q000009:adverse effects / Q000627:therapeutic use*; D014623:Vaginal Diseases / Q000188:drug therapy*
D009593:Nitroimidazoles; D009950:Ornidazole