Demonstration of anaphylatoxins C3a, C4a and C5a in the scales of psoriasis and inflammatory pustular dermatoses.
Complement components C3a, C4a and C5a were assayed in corneal scale extracts from psoriasis and other dermatoses characterized by sterile subcorneal pustules, using radioimmunoassay. Larger amounts were detected in psoriasis and related pustular dermatoses than in extracts of non-inflammatory stratum corneum. It is concluded that complement is activated via the classical pathway and releases the neutrophil chemotactic fragment C5a.
D000706:Anaphylatoxins / Q000032:analysis*; D003176:Complement C3 / Q000032:analysis; D015926:Complement C3a; D003181:Complement C4 / Q000032:analysis; D015934:Complement C4a; D003182:Complement C5 / Q000032:analysis; D015936:Complement C5a; D005533:Foot Dermatoses / Q000276:immunology*; D006229:Hand Dermatoses / Q000276:immunology*; D006801:Humans; D010455:Peptides / Q000032:analysis*; D011565:Psoriasis / Q000276:immunology*; D012867:Skin / Q000276:immunology*; D013492:Suppuration / Q000276:immunology
D000706:Anaphylatoxins; D003176:Complement C3; D003181:Complement C4; D003182:Complement C5; D010455:Peptides; D015926:Complement C3a; D015934:Complement C4a; D015936:Complement C5a