Expression of the T4 molecule (AIDS virus receptor) by human brain-derived cells.
Three human cell lines of astrocytic origin were evaluated for expression of a human T-lymphocyte surface glycoprotein, T4, which also serves as a cellular receptor for the human immunodeficiency virus (AIDS virus, HIV). T4 antigen was detected on the cell surface of 2 of these cell lines using monoclonal OKT-4 antibody and flow cytometry. Gene transcripts encoding the T4 molecule were detected by a ribonuclease protection assay in surface T4-positive and -negative cells. Our results suggest that astrocytes may serve as targets for HIV infection in the brain.
D000911:Antibodies, Monoclonal; D001253:Astrocytes / Q000378:metabolism*; D001921:Brain / Q000166:cytology*; D002460:Cell Line; D005434:Flow Cytometry; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006678:HIV / Q000378:metabolism*; D006801:Humans; D015728:Receptors, HIV; D011991:Receptors, Virus / Q000096:biosynthesis* / Q000235:genetics
D000911:Antibodies, Monoclonal; D005904:Glial Fibrillary Acidic Protein; D015728:Receptors, HIV; D011991:Receptors, Virus