[Z-DNA and autoimmune derangement].
The Z conformation of DNA seems closely related to postulated pathogenetic mechanisms of autoimmune complaints like systemic lupus erythematosus (SLE). The following findings are of importance: 1. Z DNA occurs under physiological conditions. 2. Z DNA is likely to be a target of polymerases. 3. Z DNA is immunogen. 4. Antibodies to Z DNA have been detected in both, murine and human SLE.
D000974:Antibodies, Antinuclear / Q000032:analysis; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology
D000974:Antibodies, Antinuclear; D001324:Autoantigens; C026904:deoxyribonucleoprotein antibodies; D004247:DNA
Z-DNS und autoimmune Entgleisung.