[Extramembranous glomerulopathy in chronic B lymphoid leukemia. 5 years' follow-up].
A nephrotic syndrome due to membranous nephropathy and B chronic lymphocytic leukemia were simultaneously discovered in a 52 year old patient. Proteinuria was significantly reduced with chlorambucil therapy and nephrotic syndrome disappeared. Treatment withdrawal for 5 months resulted in a significant lowering of serum albumin level, while blood lymphocyte count increased. These observations indicate a probable causal relationship between the lymphoproliferative disease and the onset of the glomerulopathy which is supported by the efficacy of the chemotherapy on the evolution of the nephrotic syndrome.
D001402:B-Lymphocytes; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000209:etiology*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology
Glomérulopathie extra-membraneuse au cours d'une leucémie lymphoïde chronique B. Recul de 5 ans.