Effect of T-lymphocyte suppression on the parasite burden in Leishmania major-infected, genetically susceptible BALB/c mice.
Treatment of Leishmania major-infected, genetically susceptible BALB/c mice with the T-lymphocyte-immunosuppressive drug cyclosporin A (CyA) resulted in a significantly reduced parasite burden in the local site of infection and in the draining lymph nodes. These data indicate that T cells are pivotal for the propagation of L. major in vivo.
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology; D007111:Immunity, Cellular; D007895:Leishmania tropica / Q000254:growth & development / Q000276:immunology; D007896:Leishmaniasis / Q000276:immunology / Q000469:parasitology*; D008198:Lymph Nodes / Q000469:parasitology; D008222:Lymphokines / Q000502:physiology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000276:immunology / Q000469:parasitology*
D003524:Cyclosporins; D008222:Lymphokines