[Studies on hemorrhagic gastritis after extended gastric devascularization using portal hypertensive dogs].
We studied a cause of postoperative hemorrhagic gastritis in the disease of portal hypertension experimentally. Five portal hypertensive dogs, produced by our whole liver compression procedure, underwent transabdominal devascularization on one-third upper gastric portion. In the gastric cardia, mucosal blood flow and tissue oxygen tension (PTO2) were measured by Hydrogen gas clearance method and PTO2 sensor for 14 days after surgery. Moreover P50, 2,3-DPG, pH, Hb, and blood temperature were also monitored for 14 days. In gastric hemodynamic changes, mucosal blood flow showed a moderate reduction immediately after surgery and returned to the previous value on the 14th postoperative day, although the value of PTO2 was dropped gradually for 14 days. Especially, postoperative changes in PTO2 showed significant correlation with P50 and 2,3-DPG. On the other hand, slight atrophic gastritis was recognized microscopically in devascularized gastric cardia. From these results, mucosal hypoxia of the upper gastric portion may be influenced by a remarkable reduction of P50 and 2,3-DPG, and it seems to easily lead to the state of hemorrhagic gastritis.
D000818:Animals; D004285:Dogs; D004932:Esophageal and Gastric Varices / Q000601:surgery*; D005753:Gastric Mucosa / Q000098:blood supply* / Q000378:metabolism; D005756:Gastritis / Q000209:etiology*; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D006975:Hypertension, Portal / Q000601:surgery*; D010101:Oxygen Consumption; D011183:Postoperative Complications / Q000209:etiology*; D012039:Regional Blood Flow