What is the role of lipid A in the development of pyelonephritis? A hypothesis.
From the studies of Westenfelder et al. and our own studies of the presence of lipid A antibodies in the upper and lower urinary tract infections, it can be concluded that chronic pyelonephritis is a lipid A induced disease. This hypothesis is based on the distinct statistically different antibody production in upper urinary tract infection in contrast to lower urinary tract infection, the persistence of lipid A in renal tissue, as well as the induction of lipid A nephritis in puppies. These observations should be considered in future studies to proceed in the clarification of these diseases.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis*; D002648:Child; D002908:Chronic Disease; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008050:Lipid A / Q000276:immunology*; D011704:Pyelonephritis / Q000209:etiology*; D014552:Urinary Tract Infections / Q000209:etiology
D000907:Antibodies, Bacterial; D008050:Lipid A