Calcitonin gene-related peptide increases survival of a musculocutaneous critical flap in the rat.
Calcitonin gene-related peptide (CGRP) was shown to increase the survival area of ischaemic tissue from 45% in control animals to about 90% in treated animals. This effect was demonstrated in a musculocutaneous flap model in the rat. The concentrations used were 2 X 10(5) times lower than those known to cause an increase in skin blood flow under normal conditions. Treatment with one single dose up to 36 h postoperatively was found to increase the flap survival area. It is suggested that the mechanism/s by which CGRP increases survival of ischaemic tissue may be different from vasodilation or that the sensitivity is altered during ischaemic conditions and that CGRP may be a powerful tool to reduce ischemia in various clinical conditions.
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D007511:Ischemia / Q000517:prevention & control; D009479:Neuropeptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013524:Surgical Flaps
D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide