title: Efficacy of diphenhydramine hydrochloride for local anesthesia before oral surgery.
abstract: The efficacy of diphenhydramine hydrochloride with epinephrine was tested against lidocaine with epinephrine in a double-blind study. Patients with allergic reactions to general local anesthetics were safely and effectively treated with diphenhydramine hydrochloride as an anesthetic alternative.
mesh_terms: D000328:Adult; D000766:Anesthesia, Dental; D000772:Anesthesia, Local; D000779:Anesthetics, Local; D004155:Diphenhydramine / Q000008:administration & dosage; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008012:Lidocaine; D008297:Male; D011229:Preanesthetic Medication; D014081:Tooth Extraction
chemical_list: D000779:Anesthetics, Local; D004155:Diphenhydramine; D008012:Lidocaine