Animal experiments on the role of T lymphocytes in the course of antineoplastic chemotherapy. II. Chemotherapy and T lymphocyte depression.
Inbred 'Strain 2' guinea pigs bearing an intradermally growing and already lymphogenetically metastasized solid tumor ('Line 10') were successfully treated by multiple intralesional chemotherapy. The animals developed tumor-specific immunity. Depression of T lymphocyte function abolished the curative effect of this therapy. After treatment with antilymphocyte serum or cyclosporin A all animals receiving intratumoral chemotherapy with cisplatinum or low-dose vincristine showed progressive tumor growth. Immunosuppression with antilymphocyte serum or cyclosporin A did not interfere with high-dose vincristine treatment.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology*; D003524:Cyclosporins / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007108:Immune Tolerance / Q000187:drug effects; D007279:Injections, Subcutaneous; D007958:Leukocyte Count / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology*; D014750:Vincristine / Q000008:administration & dosage / Q000494:pharmacology*
D000961:Antilymphocyte Serum; D003524:Cyclosporins; D014750:Vincristine; D002945:Cisplatin