Primary infection with HIV in a severely immunosuppressed patient with acute leukemia.
A 47-year-old female with acute myeloid leukemia received HIV positive platelets during induction chemotherapy. 18 days later, coincident with the recovery of the bone marrow function, she developed an erythematous rash, mild lymphadenopathy, and nausea which disappeared within 10 days. A week later mild CSF pleocytosis consisting of mature lymphocytes and macrophages together with elevated CSF protein levels (1,080 mg/l) were observed suggesting mild aseptic meningitis, and the HIV was concomitantly isolated from CSF. The CSF abnormalities have improved and the patient is well and in remission after 3 cycles of chemotherapy. This case expands the clinical spectrum of HIV infection to include a primary syndrome during immunosuppression from an unrelated cause.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000914:Antibodies, Viral / Q000032:analysis; D001803:Blood Transfusion; D005260:Female; D005500:Follow-Up Studies; D015483:HIV Antibodies; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology*; D008875:Middle Aged; D009894:Opportunistic Infections / Q000276:immunology*; D017713:Platelet Transfusion; D012074:Remission Induction
D000914:Antibodies, Viral; D015483:HIV Antibodies