A novel method of protein analysis for prediction of biological function: application to tumor toxins.
Informational spectra method was applied to the analysis of lymphotoxin and tumor necrosis factor. The correlation between the information contained in primary structure of these tumor toxins and some oncogen transforming proteins was established. This correlation implies the possibility of a competitive action between these two groups of proteins. "Hot spots" positions in the primary structure of lymphotoxin and tumor necrosis factor for the functional "up" and "down" mutations were predicted.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D006023:Glycoproteins / Q000235:genetics; D008233:Lymphotoxin-alpha / Q000235:genetics; D009154:Mutation; D009856:Oncogene Proteins, Viral / Q000235:genetics; D011487:Protein Conformation; D011506:Proteins / Q000235:genetics*; D012984:Software; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha; D014867:Water
D006023:Glycoproteins; D008233:Lymphotoxin-alpha; D009856:Oncogene Proteins, Viral; D011506:Proteins; D014409:Tumor Necrosis Factor-alpha; D014867:Water