title: New class I in man: serological and molecular characterization.
abstract: New class I antigens in linkage disequilibrium with HLA-A antigen are demonstrated in PHA T and EBV preferential target cells using human alloantisera. These new antigens are defined as class I antigens by immunoprecipitation of a 41-12 k dimer. The molecule is shown to be distinct from the HLA-A, -B, -C molecule and in particular from the A3 molecule as in sequential immunoprecipitations, the depletion of the HLA-A, -B, -C molecule or A3 molecule (44-12 k) has no effect on the new molecule (41-12 k). Being present on the PHA T cells and lymphoblast lines, these antigens are considered as new epitopes involved in the the cell activation process.
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D002648:Child; D004247:DNA / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D006680:HLA Antigens; D004247:DNA