Giant lymph node hyperplasia: a disease of primary follicle/mantle zone lymphocytes?
Histological, immunohistochemical, and immunological features of a lymph node from a patient with Castleman's disease (CD), hyaline vascular type, were investigated. The results substantiate a peculiar immunological identity of this disease. CD lymph nodes consisted mainly of polyclonal primary follicle/mantle zone lymphocytes. Germinal center cells and plasma cells were absent, while T-lymphocyte subsets were not modified.
D000911:Antibodies, Monoclonal / Q000276:immunology; D001365:Axilla; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008198:Lymph Nodes / Q000473:pathology*; D008214:Lymphocytes / Q000145:classification / Q000276:immunology
D000911:Antibodies, Monoclonal