Modulation of interleukin-1 production by macrophages following benzo(a)pyrene exposure.
The effects of benzo(a)pyrene (BaP), a highly prevalent environmental carcinogen, on the ability of peritoneal exudate macrophages to produce the secretory immunomodulatory molecule interleukin-1 (IL-1) in vitro was examined. A dose-dependent increase in lipopolysaccharide stimulated IL-1 production concomitant with decreased cell viabilities was noted in macrophages cultured in the presence of BaP. Antibody responses which are suppressed in BaP dosed mice can be reconstituted in vitro by the addition of exogenous interleukin-1. These results indicate that one of the cellular targets of BaP induced immunosuppression may be cells of the macrophage-monocyte lineage. Furthermore, BaP induced suppression of antibody responsiveness may be a result of alterations in production of IL-1.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D001564:Benzo(a)pyrene / Q000494:pharmacology*; D005260:Female; D007375:Interleukin-1 / Q000096:biosynthesis*; D007700:Kinetics; D008262:Macrophage Activation; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains
D007375:Interleukin-1; D001564:Benzo(a)pyrene