title: [High-dosage cotrimoxazole therapy of disseminated Nocardia brasiliensis infection].
abstract: After a scraping injury to the skin a 47-year-old man developed a generalized Nocardia brasiliensis infection with cutaneous, pulmonary and cerebral dissemination. There was no predisposing underlying illness. High-dosage cotrimoxazol and short-term intrathecal and systemic gentamycin administration achieved extensive healing. This form of treatment would thus seem capable of reversing the otherwise poor prognosis of generalized N. brasiliensis infection.
mesh_terms: D001922:Brain Abscess / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009617:Nocardia Infections / Q000175:diagnosis / Q000188:drug therapy*; D012867:Skin / Q000293:injuries; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000627:therapeutic use*; D014295:Trimethoprim / Q000008:administration & dosage / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014946:Wound Infection / Q000209:etiology
chemical_list: D004338:Drug Combinations; D005839:Gentamicins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole
vernacular_title: Hochdosierte Cotrimoxazol-Therapie einer disseminierten Nocardia-brasiliensis-Infektion.