Modulation of transforming growth factor type beta action by activated ras and c-myc.
Transfection of C3H/10T1/2 cells with a c-myc gene resulted in the acquisition of responsiveness to transforming growth factor type beta. Cells transfected with an activated H-ras gene or an H-ras and c-myc gene, however, exhibited a transformed morphology and spontaneous soft-agar growth, a phenotype induced reversibly by transforming growth factor type beta in responsive fibroblasts.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells / Q000166:cytology / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D010641:Phenotype; D011519:Proto-Oncogenes; D014162:Transfection; D015291:Transforming Growth Factors
D010455:Peptides; D015291:Transforming Growth Factors