Thymus-dependent increase in splenic T cell population in postpartum mice.
Cell dynamics in the thymus and spleen of mice during the first allogeneic pregnancy and during postpartum were investigated. A considerable decrease in the number of thymocytes occurred at midpregnancy and was sustained until postpartum. There was an increase in the number of splenic T cells on the third postpartum day. These splenic T cells were shown to have the Lyt-1+ 2-phenotype, as determined by multiparameter analysis, and their responsiveness to Con A was increased compared with splenic T cells of virgin mice. Since such T cells were not observed in the postpartum spleen of adult thymectomized mice, they may have derived from the thymus. The response to Con A by normal virgin spleen cells was depressed when spleen cells from 3-day postpartum mice were added to the culture as the third party cells. Thus, the increased number of splenic T cells may act as inducer cells in the suppressor circuit during postpartum.
D000818:Animals; D002634:Chemotaxis, Leukocyte; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D007108:Immune Tolerance; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009929:Organ Size; D049590:Postpartum Period; D011247:Pregnancy; D013154:Spleen / Q000166:cytology*; D013601:T-Lymphocytes / Q000145:classification / Q000187:drug effects / Q000502:physiology; D013950:Thymus Gland / Q000166:cytology / Q000502:physiology*
D003208:Concanavalin A