HLA antigens in acute measles encephalitis.
The frequency of HLA-A, B, DR antigens was studied in 24 patients with acute measles encephalomyelitis compared to 1926 control subjects. The results demonstrated no association between the susceptibility to the disease and HLA markers. However, DR4 was observed in 6 patients out of 10 who developed intrathecal secretion of specific antimeasles immunoglobulins, while absent in 4 patients, who did not (p less than 0.04). Further studies on a larger series are needed.
D002648:Child; D004660:Encephalitis / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics*; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D008457:Measles / Q000235:genetics / Q000276:immunology*
D006680:HLA Antigens; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II