title: [Control of malaria--chemotherapy and immunoprophylaxis. 1. Chemotherapy].
abstract: A survey on the advances of the fight against malaria is given, and the present world-wide situation of this disease is described including the important role World Health Organization (WHO) is playing in this fight. The chapter on chemotherapy deals with recent progress in this field with special regard to mefloquine and quinghaosu, but other newer compounds are also discussed. The prospects of vaccination against malaria in general are considered, and the results of in vitro and in vivo experiments using antigens from sporozoites, asexual blood stages and gametocytes are reported. Humoral and cellular immunity and their part in the immune response of the infected host are evaluated as well as the progress in the continuous cultivation of the malaria parasites. Finally, the perspectives of the fight against malaria in the years to come are discussed.
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use*; D037621:Artemisinins; D004338:Drug Combinations; D004351:Drug Resistance; D006801:Humans; D066298:In Vitro Techniques; D008288:Malaria / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control*; D015767:Mefloquine; D010961:Plasmodium / Q000502:physiology; D011804:Quinolines / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000627:therapeutic use; D014611:Vaccination
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D004338:Drug Combinations; D011804:Quinolines; D012717:Sesquiterpenes; C031327:artemisinin; D015767:Mefloquine
vernacular_title: Malariabekämpfung--Chemotherapie und Immunprophylaxe. 1. Mitteilung: Chemotherapie.