title: [A case of adult T-cell leukemia responding to recombinant interferon-beta (GKT-beta)].
abstract: Interferon-beta (GKT-beta) was administered to a patient with adult T-cell leukemia (ATL), presumably of acute type, with a marked organ infiltration and increases in serum calcium, LDH and bilirubin. The therapy produced a fall in the number of peripheral blood abnormal lymphocytes, disappearance of jaundice, reduction in the degree of hepatomegaly and splenomegaly and a remarkable improvement of general condition with a performance status of grade 3 improving to grade 1. The response has been maintained for more than seven months. Dose, schedule and criteria for drug discontinuation are matters for further investigation.
mesh_terms: D001663:Bilirubin / Q000097:blood; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007938:Leukemia / Q000097:blood / Q000628:therapy*; D008875:Middle Aged; D013601:T-Lymphocytes
chemical_list: D007370:Interferon Type I; D007770:L-Lactate Dehydrogenase; D001663:Bilirubin; D002118:Calcium