BSC-1 growth inhibitor/type beta transforming growth factor is a strong inhibitor of thymocyte proliferation.
Growth inhibitor/type beta transforming growth factor purified from BSC-1 cells and human platelets is shown to strongly inhibit the proliferation of Con A-stimulated mouse thymocytes. The inhibition can be achieved with growth inhibitor/type beta transforming growth factor concentrations approximately equal to 1/10th those necessary to inhibit keratinocyte cultures. The inhibitory effect in thymocyte cultures can be reversed by the addition of interleukin 2. These findings suggest that growth inhibitor/type beta transforming growth factor is a naturally occurring immunoregulator.
D000818:Animals; D002460:Cell Line; D002522:Chlorocebus aethiops; D006131:Growth Inhibitors / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects; D051379:Mice; D010455:Peptides / Q000494:pharmacology*; D012867:Skin / Q000166:cytology; D015291:Transforming Growth Factors
D006131:Growth Inhibitors; D007376:Interleukin-2; D010455:Peptides; D015291:Transforming Growth Factors