title: Increased concentrations of uric acid in the spinal cord of rats with chronic relapsing experimental allergic encephalomyelitis.
abstract: We investigated the effects of chronic relapsing experimental allergic encephalomyelitis (first attack and first recovery) on uric acid (UR) concentrations in Lewis rat spinal cord. Perchloric extracts of 9 regions between spinal cord segments C3 and Co1 were injected into a reversed-phase high-performance liquid chromatographic system, and UR was quantified electrochemically. In all regions UR, which was lower than 0.5 micrograms/g wet tissue in rats injected with adjuvant (controls), increased to a variable extent during the attack (5-12 micrograms/g, maximum in T11-L2) and returned during recovery to a residual level of 1-2 micrograms/g. These findings can be partly attributed to blood-brain barrier damage.
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D013116:Spinal Cord / Q000032:analysis*; D014527:Uric Acid / Q000032:analysis*
chemical_list: D014527:Uric Acid