[Immunohistochemical study of local immunity in carcinoma of the esophagus].
In order to elucidate the local immunity in esophageal carcinomas, infiltrating cells and cells containing Ig located in the lamina propria near the tumor and T cell subsets in the struma of the tumor were analysed quantitatively in 45 cases of intrathoracic esophageal carcinoma. Infiltrating cells were observed in the 5 mm wide lamina propria near the tumor more than in other regions. Most of them were lymphocytes and plasma cells. Infiltrating cells in the unit area (0.0056 mm2) were 16.7 +/- 6.4 in the oral area, 18.2 +/- 7.4 in the anal area. The proportion of cells containing Ig was about 50%, 45% and 3-5% for IgG, IgA and IgM, respectively. In cases with preoperative therapy infiltrating cells and cells containing IgA were fewer than in cases without preoperative therapy. In the group of well differentiated squamous cell carcinoma or in a large tumor, more than 5 cm in longitudinal diameter, or where there was no lymph node metastasis or no invasion of adventitia, many infiltrating cells and cells containing Ig were noted. There were many Leu 4 positive cells (T cells) within the struma of the tumor and Leu 2a and Leu 3a positive cells mingled in various proportions.
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000473:pathology; D004938:Esophageal Neoplasms / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000145:classification
D007136:Immunoglobulins