Induction of the c-myc protooncogene after antigen binding to hapten-specific B cells.
The stimulation of hapten-specific B cell populations with the thymus-dependent antigen, TNP-KLH, was found to induce elevated levels of c-myc mRNA by 2 h. A similar treatment with carrier protein alone did not elevate c-myc mRNA above the level seen in the nonstimulated, resting B cells. These results indicate that antigen binding to the sIg receptor, in the absence of Th cell involvement, directly signals the antigen-binding cell and implicates the active participation of sIg during the process of antigen-mediated B cell activation.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006241:Haptens / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D008811:Mice, Inbred DBA; D010716:Phosphatidylinositols / Q000378:metabolism; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000032:analysis; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D011971:Receptors, Immunologic / Q000378:metabolism
D000941:Antigens; D006241:Haptens; D010716:Phosphatidylinositols; D012333:RNA, Messenger; D011947:Receptors, Antigen, B-Cell; D011971:Receptors, Immunologic