Evidence for the presence of testicular tissue and Sxs antigen in the absence of Y-derived sequences.
Eleven XX males and seven XX true hermaphrodites have been tested for the presence of Y-derived DNA sequences using six different probes. All eleven XX males were positive with at least one of the probes but none of the seven true hermaphrodites could be shown to possess any Y-DNA. Using a new sensitive test for serologically sex-specific (Sxs) antigen, we found that, despite their apparent lack of Y-DNA, the XX true hermaphrodites were positive for their expression of the Sxs antigen.
D004247:DNA; D015342:DNA Probes; D012734:Disorders of Sex Development / Q000235:genetics*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005819:Genetic Markers; D006182:H-Y Antigen / Q000032:analysis; D006801:Humans; D007713:Klinefelter Syndrome / Q000235:genetics*; D008297:Male; D013737:Testis / Q000276:immunology*; D014960:X Chromosome; D014998:Y Chromosome
D015342:DNA Probes; D005819:Genetic Markers; D006182:H-Y Antigen; D004247:DNA