title: Sensitized photo-oxidation of thymidine by 2-methyl-1,4-naphthoquinone. Characterization of the stable photoproducts.
abstract: The near ultraviolet photolysis of an aerated aqueous solution of thymidine containing 2-methyl-1,4-naphthoquinone gives rise to two main classes of photoproducts as a result of the initial formation of a pyrimidine radical cation. These photo-oxidation products have been separated by high performance liquid chromatography and further characterized by various spectroscopic techniques including fast atom bombardment mass spectrometry and high field 1H and 13C nuclear magnetic resonance analysis. This photoreaction constitutes an excellent model to study the chemical properties of the thymidine radical cation which is expected to be one of the primary consequences of the direct effects of ionizing radiation.
mesh_terms: D010084:Oxidation-Reduction; D010777:Photochemistry; D011838:Radiation-Sensitizing Agents; D013936:Thymidine; D014812:Vitamin K
chemical_list: D011838:Radiation-Sensitizing Agents; D014812:Vitamin K; D013936:Thymidine