Nasal polyps and their content of arachidonic acid metabolites.
In three different groups of patients with nasal polyps without or with bronchial hyperreactivity and aspirin-sensitivity the content of several prostaglandin metabolites and LTC4 were measured in the polyp-tissue. A significant elevation of Thromboxane formation (TxB2) was found. The pathophysiological importance of this finding for the development of bronchial hyperreactivity in these patients is seen in context with the non-cholinergic stimulating system with consecutive substance P-formation and the role of the eosinophil cell in chronic inflammation.
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D001241:Aspirin / Q000009:adverse effects*; D015232:Dinoprostone; D004342:Drug Hypersensitivity / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism; D012130:Respiratory Hypersensitivity / Q000150:complications / Q000378:metabolism*; D013929:Thromboxane B2 / Q000378:metabolism
D005231:Fatty Acids, Unsaturated; D011458:Prostaglandins E; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D015232:Dinoprostone; D001241:Aspirin