Study of relationship between allogeneic transplantability of tumors and their effects on drug-metabolizing system in rats.
Effects of three different fibrosarcomas on the hepatic mixed-function oxidase system were studied in males of the Lewis inbred strain of rats. No association between graded potentiality of these tumors to grow across histocompatibility barriers and their suppressive effects upon the microsomal drug-metabolizing system was found.
D015660:7-Alkoxycoumarin O-Dealkylase; D000633:Aminopyrine N-Demethylase / Q000032:analysis; D000818:Animals; D002460:Cell Line; D005354:Fibrosarcoma / Q000201:enzymology* / Q000473:pathology; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009368:Neoplasm Transplantation; D010105:Oxygenases / Q000032:analysis; D051381:Rats; D011917:Rats, Inbred Lew; D013050:Spectrometry, Fluorescence
D006899:Mixed Function Oxygenases; D010105:Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase; D000633:Aminopyrine N-Demethylase