[Functioning of the pituitary-adrenal system during the vestibulo-vegetative syndrome and administration of dalargin and nalorphine].
Changes in ACTH, cortisol, beta-endorphin have been investigated during vestibulo-vegetative syndrome (VVS) and injections of dalargin (leu-enkephalin analog) and nalorphine (agonist-antagonist of opioid receptors) in 9 volunteers with low level vestibulo-vegetative stability. Cumulative coriolis acceleration test during rotations on a special chair was used for VVS modelling. Dalargin (1-4 mg), nalorphine (5 mg) and placebo (NaCl solution) were injected intravenously 5-15 min before rotation. A significant increase in ACTH, cortisol and beta-endorphin plasma levels has been observed. Mean positive linear correlation (r greater than +0.6) between ACTH and beta-endorphin and ACTH and cortisol was noted immediately after the test only when dalargin was injected. It is suggested that in VVS there develops a hormonal conflict, i. e. an adequate hormonal release is disturbed.
D001342:Autonomic Nervous System Diseases / Q000188:drug therapy* / Q000503:physiopathology; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D006801:Humans; D007759:Labyrinth Diseases / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D009269:Nalorphine / Q000627:therapeutic use*; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000503:physiopathology*; D013577:Syndrome; D014722:Vestibule, Labyrinth / Q000187:drug effects* / Q000503:physiopathology
D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D009269:Nalorphine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Funktsionirovanie sistemy gipofiz-kora nadpochechnikov pri vestibulovegetativnom sindrome na fone vvedeniia dalargina i nalorfina.