Gastroprotective and ulcer healing effects of solon, a synthetic flavonoid derivative of sophoradin.
Solon, a synthetic isoprenyl flavonoid derived from sophoradin isolated from the root of an ancient Chinese plant, administered orally to rats, prevented, dose-dependently, the formation of acute gastric lesions produced by absolute ethanol given orally. Solon also enhanced the healing of chronic gastric and duodenal ulcerations induced by the serosal application of acetic acid. The gastroprotective action of Solon was probably mediated by increased mucosal content of prostaglandins (PG) due mainly to the inhibition of 15-OH-prostaglandin dehydrogenase. The ulcer-healing action of Solon was probably related to the stimulation of mucus-alkaline secretion, increased mucosal blood flow and the formation of a protective barrier on the ulcer base.
D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001639:Bicarbonates / Q000378:metabolism; D002599:Chalcone / Q000031:analogs & derivatives / Q000627:therapeutic use*; D047188:Chalcones; D015232:Dinoprostone; D000431:Ethanol; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000378:metabolism; D010437:Peptic Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D011427:Propiophenones / Q000627:therapeutic use*; D011458:Prostaglandins E / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy
D000085:Acetates; D000897:Anti-Ulcer Agents; D001639:Bicarbonates; D047188:Chalcones; D011427:Propiophenones; D011458:Prostaglandins E; C035032:sofalcone; D000431:Ethanol; D002599:Chalcone; D015232:Dinoprostone; D019342:Acetic Acid