Effects of long-term exercise and high-cholesterol diet on lipid-lipoprotein metabolism in rats.
To accelerate the synthesis of endogenous lipids, Wistar male rats were administered sucrose solution and standard chow diet for 5 weeks. The diet was then changed to tap water plus a high-cholesterol (Cho) diet and the animals were subjected to treadmill running for 5 weeks. The concentrations of serum triglyceride (TG) and very low density lipoprotein (VLDL)-cho in the group that had endurance exercise and was fed high-Cho diet were significantly lower than those in the non-exercise group that was fed high-Cho diet. However, the exercise-high-Cho group accumulated quantities of lipids in the liver similar to the non-exercise-high-Cho group and developed a markedly fatty liver. In conclusion, it is suggested that long-term exercise did not accelerate hepatic lipid metabolism and seemed to suppress synthesis and release of VLDL in the liver.
D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL / Q000097:blood; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D010805:Physical Conditioning, Animal; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol