Natural course and prognosis of HLA-B27-positive oligoarthritis.
A long-term follow-up of 119 patients with the descriptive diagnosis of B27-positive oligoarthritis showed that after a time between months to several years about half of the patients with this condition develop a definite disease of the seronegative spondarthritis group, especially ankylosing spondylitis. Another great part of the patients go into a complete and presumably persistent remission of their arthritis. After a follow-up time of 8 to 12 years, about 10% present a recurrent B27-associated oligoarthritis with some special clinical features. It is to be discussed whether this condition is a separate disease entity or still an abortive form of a well-known disease of the seronegative spondarthritis group.
D016918:Arthritis, Reactive / Q000235:genetics; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen; D006801:Humans; D010003:Osteoarthritis / Q000235:genetics; D011379:Prognosis; D012307:Risk Factors; D013167:Spondylitis, Ankylosing / Q000235:genetics
D006680:HLA Antigens; D015796:HLA-B27 Antigen