Recurrent HSR in the centromeric region of chromosome 8 in breast cancer.
In a sample of 44 human breast cancers, the presence of HSRs was detected in 15 cases (36%). The occurrence of HSRs seems correlated poorly with tumor progression, but the number of HSRs per cell certainly does. Chromosome 8 was the most frequently involved, and the HSRs were always located near its centromere, suggesting that an amplification of gene(s) located in this region has occurred. Among these, LHRH is a candidate, but further studies are needed to confirm or reject this hypothesis.
D001943:Breast Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002898:Chromosomes, Human, Pair 8; D005260:Female; D005784:Gene Amplification; D006801:Humans; D007621:Karyotyping