Effect of acute and chronic ethanol administration in rats on PGE2 formation in microsomes from stomach and small intestine.
Prostaglandin E2 formation and content has been measured in the stomach and small intestine of rats after acute and chronic ethanol ingestion. Chronic ethanol administration for 6 and 12 weeks inhibits PGE2 synthesis and reduces PGE2 content (12 weeks) in all parts of the upper gastrointestinal tract, while after ethanol ingestion up to 1 week PGE2 synthesis is decreased only in the stomach.
D000818:Animals; D015232:Dinoprostone; D004386:Duodenum / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects*; D008297:Male; D008861:Microsomes / Q000187:drug effects* / Q000378:metabolism; D011458:Prostaglandins E / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects*
D011458:Prostaglandins E; D000431:Ethanol; D015232:Dinoprostone