Effects of coronary bypass surgery under high-dose fentanyl anaesthesia on granulocyte chemiluminescence.
Phagocytosis provides one of the body's first-line defences against invading bacteria. The present study evaluated granulocyte microbicidal-related oxidative mechanisms by measurement of chemiluminescence responses in the phagocytosis of zymosan, S. aureus, E. coli and N-formyl-methionyl-leucylphenylalanine (FMLP) in 12 patients undergoing coronary bypass surgery under high-dose fentanyl anaesthesia. With preoperative values as a baseline, a significant depression of in vitro responses to zymosan was seen on days 1, 3-4 after operation and to S. aureus and E. coli on days 3-4 after operation, with recovery by days 6-7. Responses to FMLP were unaffected.
D000771:Anesthesia, Intravenous; D001026:Coronary Artery Bypass; D005283:Fentanyl / Q000008:administration & dosage*; D006098:Granulocytes / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008163:Luminescent Measurements; D008875:Middle Aged; D010587:Phagocytosis; D011184:Postoperative Period
D005283:Fentanyl