title: Periodontium destruction associated with oncology therapy. Five case reports.
abstract: Radiation treatment to the head and neck and cytotoxic chemotherapy can produce deleterious side effects to the periodontium that are generally transient in nature, reversible, and do not result in permanently visible defects. However, combinations of the malignant disease itself, the direct and indirect effects of medical therapy and associated oral infections, along with local trauma can lead to periodontal tissue destruction with resulting permanent architectural defects. Five case reports illustrate destructive alterations of the periodontium that were associated with oncology therapy. Proposed guidelines for periodontal treatment of compromised individuals undergoing oncology therapies are suggested.
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009336:Necrosis; D010510:Periodontal Diseases / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D010519:Periodontium / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D011878:Radiotherapy / Q000009:adverse effects*; D013280:Stomatitis / Q000139:chemically induced / Q000209:etiology / Q000473:pathology