Inositol 1,4,5-trisphosphate and 5'-GTP induce calcium release from different intracellular pools.
It has been shown recently by several groups that 5'-GTP can release calcium from intracellular compartments independently from inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) by a mechanism which seems to be different from that used by Ins(1,4,5)P3. We report here for the first time that the 5'-GTP-sensitive and the Ins(1,4,5)P3-sensitive calcium pools reside in different intracellular compartments.
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D002451:Cell Compartmentation; D002499:Centrifugation, Density Gradient; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000494:pharmacology*; D006168:Guinea Pigs; D015544:Inositol 1,4,5-Trisphosphate; D007295:Inositol Phosphates / Q000494:pharmacology*; D010306:Parotid Gland / Q000378:metabolism / Q000648:ultrastructure; D013347:Subcellular Fractions / Q000032:analysis; D013403:Sugar Phosphates / Q000494:pharmacology*
D007295:Inositol Phosphates; D013403:Sugar Phosphates; D015544:Inositol 1,4,5-Trisphosphate; D006160:Guanosine Triphosphate; D002118:Calcium