Localization and fine structure of calcitonin gene-related peptide (CGRP)-like immunoreactive nerve fibres in the organ of Corti of guinea pigs by immunohistochemistry.
The localization and fine structure of calcitonin gene-related peptide (CGRP)-like immunoreactive (CGRPI) fibres in the guinea pig cochlea were examined using immunohistochemistry. Numerous CGRPI fibres were located in the inner spiral bundle corresponding to the lateral system of the olivocochlear bundle. Immunoelectron microscopic analysis demonstrated that the CGRPI fibres belonged to the efferent terminals and some of them made synaptic contacts with peripheral neurites of the auditory nerve. These findings suggested that the olivocochlear CGRP neuron system influenced the neural activity of the auditory nerve, which conveys auditory information from the cochlea to the central nervous system.
D000818:Animals; D002116:Calcitonin / Q000032:analysis*; D015740:Calcitonin Gene-Related Peptide; D003051:Cochlea / Q000294:innervation; D006168:Guinea Pigs; D007120:Immunochemistry; D009412:Nerve Fibers / Q000032:analysis; D009479:Neuropeptides / Q000032:analysis*; D009925:Organ of Corti / Q000032:analysis / Q000033:anatomy & histology* / Q000648:ultrastructure
D009479:Neuropeptides; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide