[Cell-mediated immunity in patients with atopic allergic diseases].
Some parameters of cellular-mediated immunity in patients with atopic bronchial asthma and pollinosis rhinitis were studied. A statistically significant reduction of suppressor and active subpopulation was established as well as of the total fraction T-lymphocytes and a growth in the helper-suppressor ratio. A statistically significant reduction of lymphocytic reactivity to phytohemagglutinins was also established via blasttransformation test as compared with a group of healthy subjects. The results obtained convincingly confirmed a quantitative and functional T-cellular immunodeficiency in atopy. The clinical improvement of the patients with atopic bronchial asthma that were conducted a specific hyposensibilization for over 6 months, was accompanied by increase of T-suppressors and active T-cells and reduction of immuno-regulatory index. Some practical trends in the early diagnosis of immunodeficient state in atopic diseases are discussed.
D000293:Adolescent; D000328:Adult; D000485:Allergens; D001249:Asthma / Q000276:immunology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology
D000485:Allergens
Kletŭchnomediran imunitet pri bolni ot atopichni alergichni zaboliavaniia.