Effects of tenoxicam on nociceptive thalamic neuronal firing in arthritic rats.
The antinociceptive action of tenoxicam, a new non-steroidal anti-inflammatory drug, has been investigated by exploring the spontaneous and evoked electrophysiological patterns of firing of thalamic neurons in arthritic rats. A marked decrease in the firing activity evoked by ankle mobilization has been found to be present at doses of tenoxicam of 0.6 mg/kg i.v. A similar effect is obtainable with aspirin (as reference drug) but with doses of 54 mg/kg i.v. On studying the effects of increasing doses of tenoxicam a progressively longer time-course inhibition has been found and the analysis confirmed a linear correlation. Findings are discussed postulating that the final antinociceptive effect of tenoxicam can be correlated with its anti-inflammatory activity.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001168:Arthritis / Q000503:physiopathology*; D001169:Arthritis, Experimental / Q000503:physiopathology*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D009619:Nociceptors / Q000187:drug effects*; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013788:Thalamus / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; C032801:tenoxicam