Perforating granuloma annulare in a patient with acquired immunodeficiency syndrome. Immunohistologic evaluation of the cellular infiltrate.
The inflammatory infiltrate found in the lesions of perforating granuloma annulare in a patient with acquired immunodeficiency syndrome was analyzed. Double labeling with fluorescent antibody tags fluorescein isothiocyanate-Leu 4 (peripheral T cells) and phycoerythrin-Leu 2a (cytotoxic/suppressor) revealed the infiltrate to consist predominantly of cytotoxic/suppressor T cells. This finding is a reflection of the patient's altered immune status and calls into question the role of specific T-cell subsets in the pathogenesis of granuloma annulare.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001706:Biopsy; D005528:Foot / Q000473:pathology*; D005533:Foot Dermatoses / Q000276:immunology / Q000473:pathology*; D006099:Granuloma / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D009336:Necrosis; D013601:T-Lymphocytes / Q000145:classification