title: Complement depletion suppresses Lewis rat experimental allergic neuritis.
abstract: Lewis rats immunized with myelin and complete Freund's adjuvant were treated with cobra venom factor (CVF) which depletes the C3 component of complement. CVF given at day 9 delayed the onset of experimental allergic neuritis (EAN) by 2-3 days and when given at days 9 and 12 delayed the onset of EAN by 4-5 days. Lumbar nerve roots of CVF-treated rats had significantly less demyelination than those from control EAN rats.
mesh_terms: D000818:Animals; D003039:Cobra Neurotoxin Proteins; D003167:Complement Activation / Q000187:drug effects; D003176:Complement C3 / Q000097:blood / Q000276:immunology*; D005620:Freund's Adjuvant; D008297:Male; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology* / Q000503:physiopathology; D051381:Rats; D011917:Rats, Inbred Lew; D013126:Spinal Nerve Roots / Q000276:immunology / Q000473:pathology; D013997:Time Factors
chemical_list: D003039:Cobra Neurotoxin Proteins; D003176:Complement C3; D005620:Freund's Adjuvant