The effects of verapamil on the locomotor-activating properties of corticotropin releasing factor (CRF) in the rat.
CRF was administered to rats following intracerebroventricular administration of the calcium antagonist verapamil. Treatment with verapamil elicited biphasic dose-response effects on rat locomotor activity: doses equimolar to CRF treatment slightly increased CRF-stimulated locomotion, while doses of verapamil ten times greater slightly depressed CRF-stimulated locomotion. These results suggest that CRF-stimulated locomotion, unlike other effects of CRF, is not mediated in a simple way by processes dependent on neuronal calcium influx.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002118:Calcium / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage*; D004347:Drug Interactions; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000008:administration & dosage*
D003346:Corticotropin-Releasing Hormone; D014700:Verapamil; D002118:Calcium