Increased frequencies of alpha-naphthoflavone induced sister chromatid exchanges in long-term survivors of childhood acute lymphoblastic leukemia.
Cultures of whole-blood were established from 12 children (mean age = 13.5 years) surviving acute lymphoblastic leukemia (mean time of discontinued therapy = 4.5 years) and 10 age-matched controls were assessed for the level of baseline, alpha-naphthoflavone (ANF) and methyl-methane-sulphonate (MMS) induced sister chromatid exchanges (SCEs). The average baseline levels of SCEs in the patient group (7.65) and in the control (6.72) were different at a statistical marginal level (P = 0.05). No statistical difference was observed in the levels of MMS-induced SCEs between the two groups (P greater than 0.1). In contrast, highly significant differences (P = 0.003) were observed in the level of ANF-induced SCE-levels between the patients (10.78) and the controls (8.76).
D000293:Adolescent; D001571:Benzoflavones / Q000378:metabolism / Q000494:pharmacology*; D002648:Child; D004260:DNA Repair; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics*; D008214:Lymphocytes / Q000648:ultrastructure; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D001571:Benzoflavones; D005419:Flavonoids; C011512:alpha-naphthoflavone; D008741:Methyl Methanesulfonate