Inhibitory effect of fumaric acid on hepatocarcinogenesis by thioacetamide in rats.
An inhibitory effect of fumaric acid (FA) on hepatocarcinogenesis was examined in rats fed thioacetamide (TAA). A group of male DONRYU rats were fed TAA at a level of 0.035% in the diet for 40 weeks and then fed a basal diet for 40 weeks. Hepatic carcinomas developed in 9 of 41 animals of this group fed TAA alone. The effect of FA on the carcinogenesis was examined in 2 groups fed both TAA and FA; one group of rats were fed FA at 1% in a basal diet after ingestion of TAA, and another group of rats were fed TAA plus a supplement of 1% FA in the diet. The inhibitory effect of FA on TAA carcinogenesis was so marked that no hepatic carcinomas were found in both groups fed FA in combination with TAA.
D000081:Acetamides / Q000633:toxicity*; D000818:Animals; D005650:Fumarates / Q000494:pharmacology*; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008749:Methyldimethylaminoazobenzene; D051381:Rats; D013853:Thioacetamide / Q000633:toxicity*
D000081:Acetamides; D005650:Fumarates; D013853:Thioacetamide; D008749:Methyldimethylaminoazobenzene; C032005:fumaric acid