[von Willebrand syndrome].
The von Willebrand syndrome is probably the most frequent heritable bleeding disorder. The pathophysiological key-role plays the impaired platelet adhesion at sites of vascular injury. It is caused by the quantitative or qualitative abnormal von Willebrand factor. Experimental work of previous years led to a better understanding of the structure and function of the factor VIII-von Willebrand factor complex. This knowledge was important for a new classification of the von Willebrand disease.
D001161:Arteriosclerosis / Q000150:complications; D006801:Humans; D010973:Platelet Adhesiveness; D014842:von Willebrand Diseases / Q000097:blood* / Q000145:classification / Q000628:therapy; D014841:von Willebrand Factor / Q000502:physiology
D014841:von Willebrand Factor
Das von Willebrand Syndrom.