Posttraumatic complications and inflammatory mediators.
In a series of 71 patients with trauma, we measured weekly the blood levels of a number of complement proteins and activation products. We also measured the following: leukocytes, platelets, granulocyte enzyme elastase, alpha 1-antitrypsin, total protein, albumin, haptoglobin, and fibronectin. The intensity of complement activation and the blood levels of elastase correlated with the following factors: injury severity (especially the severity of limb injury), development of adult respiratory distress syndrome, development and severity of multiple organ failure, and probability of a fatal outcome. The plasma elastase level seemed to be the best predictor of adult respiratory distress syndrome and the best correlate of injury severity and multiple organ failure severity. Our findings support the hypothesis that posttraumatic activation of the complement system leads to activation of granulocytes, followed by microvascular injury and finally by organ failure.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003167:Complement Activation; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006098:Granulocytes / Q000201:enzymology; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood* / Q000209:etiology; D010196:Pancreatic Elastase / Q000097:blood; D012128:Respiratory Distress Syndrome / Q000097:blood* / Q000209:etiology; D014947:Wounds and Injuries / Q000097:blood* / Q000150:complications / Q000276:immunology; D000515:alpha 1-Antitrypsin / Q000032:analysis
D000515:alpha 1-Antitrypsin; D003165:Complement System Proteins; D010196:Pancreatic Elastase