Detection of IgG subclass-specific anti-IgE antibodies in normal and atopic individuals.
Atopic dermatitis and atopic asthma patients were shown to have elevated IgG anti-IgE levels compared with those of controls. When the pattern of IgG subclass anti-IgE activity was studied, further differences between the three groups became apparent. Adults with atopic dermatitis had elevated IgG1 and IgG4 anti-IgE compared with those of controls but no corresponding increase in the IgG2 or IgG3 subclasses. For Sri Lankan children with atopic asthma and a high incidence of Nematoda infection, elevated anti-IgE was restricted to the IgG1 subclass. While IgG1 anti-IgE proved to be the predominant subclass for both atopic groups, IgG2 anti-IgE was the major subclass among controls.
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis* / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000276:immunology; D001249:Asthma / Q000276:immunology; D002648:Child; D003877:Dermatitis, Contact / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology*; D007074:Immunoglobulin G / Q000145:classification* / Q000276:immunology; D009194:Myeloma Proteins / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D009194:Myeloma Proteins; C026408:anti-IgE antibodies; D007073:Immunoglobulin E