Absence of interaction between ofloxacin and phenprocoumon.
The effect of ofloxacin on steady-state phenprocoumon pharmacodynamics was investigated in 7 healthy male volunteers taking daily sub-therapeutic doses of phenprocoumon. Ofloxacin 200 mg once daily for 7 days did not alter the anti-coagulant response (Quick values) to phenprocoumon after a stabilization phase of 2 weeks. Mean Quick values during the steady-state phase before and during ofloxacin administration were 54% and 52%, respectively. In vitro studies with concentrations of 0 to 100 mg ofloxacin/1 added to plasma also failed to show any interaction. The results indicate, therefore, that ofloxacin does not interfere with vitamin K-dependent coagulation cascade, as seen after other antibiotics.
D015110:4-Hydroxycoumarins / Q000494:pharmacology*; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D004347:Drug Interactions; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology*; D010644:Phenprocoumon / Q000494:pharmacology*
D015110:4-Hydroxycoumarins; D010078:Oxazines; D015242:Ofloxacin; D010644:Phenprocoumon