Determination of estrogen and androgen receptors in Trichomonas vaginalis and the effects of antihormones.
Trichomonas vaginalis, a common genital pathogen, was found to possess both specific estrogen and specific androgen receptors. These 4.3 S macromolecules were proteinaceous in nature. Both metronidazole-resistant and metronidazole-sensitive strains possessed both types of sex hormone-binding proteins. The estrogen receptor binding was competitively inhibited by the antiestrogen tamoxifen citrate, and the androgen binding was competitively inhibited by the antiandrogen cyoctol. The presence of these specific receptors may allow the use of hormonal and antihormonal manipulation in the treatment of infections caused by these organisms.
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D007659:Ketones; D011944:Receptors, Androgen / Q000032:analysis* / Q000187:drug effects; D011959:Receptors, Estradiol / Q000032:analysis* / Q000187:drug effects; D011960:Receptors, Estrogen / Q000032:analysis*; D013629:Tamoxifen / Q000494:pharmacology*; D014246:Trichomonas vaginalis / Q000187:drug effects / Q000378:metabolism*
D000726:Androgen Antagonists; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D007659:Ketones; D011944:Receptors, Androgen; D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D013629:Tamoxifen; C046699:cioteronel