L-5-hydroxytryptophan attenuates positive psychotic symptoms induced by D-amphetamine.
Brain serotonin has been hypothesized to be involved in the modulation of psychotic symptoms in at least some forms of schizophrenia. We examined the effects of the serotonin precursor L-5-hydroxytryptophan (5HTP) on D-amphetamine induction of acute psychotic symptoms in schizophrenic patients. Preadministration with 5HTP significantly antagonized amphetamine-elicited elevations in thought disturbance, activation, and hallucinations.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000328:Adult; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors*; D006801:Humans; D012565:Schizophrenic Psychology; D012701:Serotonin / Q000502:physiology
D012701:Serotonin; D006916:5-Hydroxytryptophan; D003913:Dextroamphetamine