title: Clinical experience with ofloxacin in upper and lower urinary tract infections. A comparison with co-trimoxazole and nitrofurantoin.
abstract: The efficacy and tolerance of ofloxacin were compared with those of co-trimoxazole in upper urinary tract infections (UTIs) and nitrofurantoin in lower UTIs in a prospective, controlled, randomised, observer-blind study. Ofloxacin proved to be an effective and well-tolerated substance. The clinical cure rate was more pronounced than that of both comparative drugs and ofloxacin was also superior to co-trimoxazole and nitrofurantoin in terms of bacterial elimination. A second, controlled study showed that single doses of ofloxacin 100mg were clinically and bacteriologically as effective as a 3-day course of ofloxacin 100mg twice daily in women with uncomplicated lower UTIs.
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009582:Nitrofurantoin / Q000009:adverse effects / Q000627:therapeutic use*; D015242:Ofloxacin; D010078:Oxazines / Q000009:adverse effects / Q000627:therapeutic use*; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D013420:Sulfamethoxazole / Q000009:adverse effects / Q000627:therapeutic use*; D014295:Trimethoprim / Q000009:adverse effects / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations; D010078:Oxazines; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D009582:Nitrofurantoin; D015242:Ofloxacin; D014295:Trimethoprim; D013420:Sulfamethoxazole