[Mechanism of the protective action of cobamamide and leucovorin on hematopoiesis in acute blood loss].
Leucovorin and cobamamide administered alone and in combination potentiate the proliferative activity of the erythroid and myeloid cells of the bone marrow. There is lack in mutual potentiation of the drugs.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002455:Cell Division / Q000187:drug effects; D003038:Cobamides / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006410:Hematopoiesis / Q000187:drug effects*; D006470:Hemorrhage / Q000097:blood / Q000188:drug therapy*; D002955:Leucovorin / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D003038:Cobamides; C000913:cobamamide; D002955:Leucovorin
K mekhanizmu protektivnogo deĭstviia kobamamida i leĭkovorina na krovetvorenie pri ostroĭ krovopotere.