S-100-protein-positive dendritic cells in nodular vasculitis.
We investigated the distribution of S-100-protein-positive dendritic cells in 20 cases of nodular vasculitis (erythema induratum Bazin). The cells were identified by immunohistochemical demonstration in paraffin sections. S-100-protein-positive dendritic cells were present in all cases and comprised up to 11% of the infiltrating cells in lymphohistiocytic areas (mean 3.7%). Because of the dendritic shape and the association with lymphocytes the cells are considered to represent T-zone histiocytes. Our findings suggest a possible role of delayed-type hypersensitivity in nodular vasculitis.
D000328:Adult; D004891:Erythema Induratum / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis*; D013601:T-Lymphocytes / Q000032:analysis*; D014382:Tuberculosis, Cutaneous / Q000276:immunology*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000209:etiology / Q000276:immunology / Q000473:pathology
D009418:S100 Proteins