Topical folinic acid therapy in methotrexate-induced oral ulceration.
A case of severe oral ulceration, following administration of combination chemotherapy which included methotrexate, is reported. Topically applied folinic acid was effective in facilitating resolution of the oral lesions.
D000287:Administration, Topical; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D009059:Mouth Diseases / Q000139:chemically induced* / Q000188:drug therapy; D009062:Mouth Neoplasms / Q000188:drug therapy; D014456:Ulcer / Q000139:chemically induced* / Q000188:drug therapy
D002955:Leucovorin; D008727:Methotrexate