Vitamin D metabolites in synovial fluid.
This study has shown that it is possible to measure vitamin D metabolites and vitamin D binding protein (DBP) in synovial fluid as well as serum. Significant amounts of 25-OHD, 24,25-(OH)2D, and DBP are present in synovial fluid. The 25-OHD and DBP maintain a serum:synovial fluid ratio of approximately 2:1 irrespective of the type of joint disease, whereas no such relationship was detected for 24,25-(OH)2D. The possible reasons for these findings are diffusion of the metabolites into synovial fluid or local production from suitable precursors, or both.
D015650:24,25-Dihydroxyvitamin D 3; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D002112:Calcifediol / Q000378:metabolism; D004100:Dihydroxycholecalciferols / Q000378:metabolism; D006801:Humans; D010003:Osteoarthritis / Q000378:metabolism; D013582:Synovial Fluid / Q000032:analysis*; D014807:Vitamin D / Q000378:metabolism*; D014809:Vitamin D-Binding Protein / Q000378:metabolism*
D004100:Dihydroxycholecalciferols; D014809:Vitamin D-Binding Protein; D014807:Vitamin D; D015650:24,25-Dihydroxyvitamin D 3; D002112:Calcifediol