Studies on the mechanisms of the development of lupus nephritis in BXSB mice. I. Analyses of immunological abnormalities at the onset period.
Immunological abnormalities observed in male BXSB mice at the onset of lupus nephritis were examined. For this purpose, 60 male and 28 female BXSB mice were examined at the age of 13 weeks. Male mice showed higher values in all the parameters tested, though big variation was observed in each parameter. Correlation studies among each parameter in male mice showed that degree of the deposition of IC in the glomeruli was very closely associated with the level of circulating immune complexes (IC) and also the number of IgG-producing cells (IgGPC) but not with that of IgMPC. No significant correlation was observed between the level of IgG anti-DNA antibodies and that of IC, nor the number of IgGPC. These results convincingly indicate the relevance of enhanced IgG production in the pathogenesis of lupus nephritis.
D000818:Animals; D004277:DNA, Single-Stranded / Q000276:immunology; D005260:Female; D007074:Immunoglobulin G / Q000502:physiology*; D007075:Immunoglobulin M / Q000502:physiology; D007376:Interleukin-2 / Q000096:biosynthesis; D007678:Kidney Glomerulus / Q000276:immunology; D008181:Lupus Nephritis / Q000209:etiology / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D008934:Mitogens / Q000494:pharmacology; D013154:Spleen / Q000276:immunology; D014301:Trinitrobenzenes / Q000276:immunology
D004277:DNA, Single-Stranded; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007376:Interleukin-2; D008934:Mitogens; D014301:Trinitrobenzenes