The combined effect of cinnarizine and domperidone on vestibular susceptibility.
Four test medications were randomly examined in 25 volunteers for the depressant effect on the labyrinth during stimulation in a rotation chair as well as in a parallel swing. The medications, placebo (pl), Domperidone 30 mg (D), Cinnarizine 40 mg (C) and Touristil 40 mg + 30 mg (C+D), were tested at 1-week intervals, the duration and amplitude of nystagmus having been recorded 15 min, 30 min, 1, 2, 3 and 4 h after intake of the medication. In both tests Touristil (C+D) was significantly (p less than 0.01) to very significantly (p less than 0.0001) more potent, more rapid, and longer working than placebo and the separate components (C) and (D). In addition the working of Touristil was specifically superior to Cinnarizine, when given separately. It appears that the new preparation Touristil approaches the profile of the ideal drug against motion sickness more closely than any other medication.
D000284:Administration, Oral; D000328:Adult; D002936:Cinnarizine / Q000494:pharmacology*; D004294:Domperidone / Q000494:pharmacology*; D004311:Double-Blind Method; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D009041:Motion Sickness / Q000188:drug therapy; D009760:Nystagmus, Physiologic / Q000187:drug effects; D011897:Random Allocation; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D004338:Drug Combinations; C052046:touristil; D002936:Cinnarizine; D004294:Domperidone