Prostaglandin modulation of the postnatal development of T and B lymphocytes in the spleens of newborn mice.
The effects of prostaglandin E2 (PGE2) on postnatal development of the T and B cells in the spleen were studied to investigate the relationship between in vivo PG concentration and immunological development of peripheral lymph organs after birth. The development of the T and B cells were suppressed by the PGE2 injection, while augmented by the indomethacin injection. Especially in the T cells, cellular immigration from the thymus to the spleen was suppressed by the PG injection. Therefore, in vivo PG concentration in postnatal period might have some affect on the development of peripheral lymph organs, and the cellular traffic from central to peripheral lymph organs.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D001402:B-Lymphocytes / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D003864:Depression, Chemical; D015232:Dinoprostone; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology; D007958:Leukocyte Count / Q000187:drug effects; D051379:Mice; D011458:Prostaglandins E / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*; D013601:T-Lymphocytes / Q000187:drug effects*
D011458:Prostaglandins E; D015232:Dinoprostone; D007213:Indomethacin