[Effect of antiglobulin serum on the expression of M-cholinoreceptors of spleen lymphocytes of intact and immunized mice].
Using a labelled blocker of M-cholinoreceptors (M-CR)--3H-Quinuclidinyl benzilate--the number of the receptors on spleen lymphocytes has been determined before and after immunization of CBA and BALB/c mice with antiglobulin serum. The incubation of non-separated spleen cell suspension with antiglobulin serum decreased the number of M-CR by 14%, while the incubation of the enriched B-lymphocyte suspension decreased it by 32.5%. The immunization of animals with ovalbumin or bovine red blood cells increased the serum effect on M-CR expression in non-separated lymphocyte suspension and had practically no influence on the serum effect in B-lymphocyte suspension. Thus, the effect on immunoglobulin receptors of B lymphocytes has a pronounced influence on M-CR expression, which may be one of the mechanisms of nervous and immune systems interaction.
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D007106:Immune Sera / Q000494:pharmacology*; D007114:Immunization; D051379:Mice; D011976:Receptors, Muscarinic / Q000378:metabolism*
D007106:Immune Sera; D011976:Receptors, Muscarinic
Vliianie antiglobulinovoĭ syvorotki na ékspressiiu M-kholinoretseptorov limfotsitov selezenki intaktnykh i immunizirovannykh mysheĭ.