Delayed dental development and pulmonary disease severity in children with cystic fibrosis.
The relationships among development of the succedaneous mandibular dentition, chronologic age, a clinically-derived prognostic score and duration of therapeutic intervention were studied in 23 females and 27 males with cystic fibrosis (CF). Radiographically-determined dental age was significantly delayed. Although significant correlations were obtained between dental and chronologic age, none were observed between delays in dental development and either the measure of pulmonary disease severity or age at CF diagnosis. The findings are not consistent with a pathologic aetiology for the reported dental delays or with being a secondary consequence of the stresses of the disease. The delay seems to be an endocrine-mediated pleiotropic effect of the cystic fibrosis locus.
D000293:Adolescent; D000367:Age Factors; D002648:Child; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000209:etiology / Q000503:physiopathology; D008297:Male; D014070:Tooth / Q000254:growth & development*