title: [Chemotherapy of advanced and recurrent colorectal cancer].
abstract: Colorectal cancer is one of the most resistant tumors to chemotherapy. The efficacy of many kinds of anti-tumor drugs to the patients with colorectal cancer had been investigated, however most of the drugs was not effective or showed low response rates. As a few effective anti-tumor drug, 5-FU and its derivatives, nitrosoureas and mitomycin C were indicated. Response rates of combinations of these drugs were 20-30%. Methotrexate-5-FU with leucovorin therapy at proper administration intervals showed relatively high response rate to the patients. Effects of intra-arterial infusion of the drugs which often performed to the liver metastases were not so well as expected. Developments of new anti-tumor agents were essential.
mesh_terms: D000804:Angiotensin II / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000628:therapy; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D006979:Hyperthermia, Induced; D007261:Infusions, Intra-Arterial; D002955:Leucovorin / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000628:therapy
chemical_list: D000804:Angiotensin II; D002955:Leucovorin; D005472:Fluorouracil; D008727:Methotrexate