title: Acoustic neuromas: Gd-DTPA enhancement in MR imaging.
abstract: Magnetic resonance (MR) imaging examinations were performed in ten patients with 12 acoustic neuromas before and after intravenous administration of 0.1 mmol/kg body weight gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). The degree of enhancement was greatest with the inversion recovery sequence 1,500/500/44 (repetition time [TR]/inversion time/echo delay time [TE]), followed by spin-echo (SE) 544/44 (TR/TE) sequences, then by SE 1,500/44 and SE 1,500/80 sequences. After enhancement there was a 50% reduction for measured T1 values, 33% for T2, and no significant change for proton density. There were no toxic effects on patients. Enhanced CT scans failed to demonstrate lesions in six of 12 cases. Air-CT technique improved sensitivity in four of five cases. Enhanced MR imaging added significant clinical information in two small intracanalicular tumors and in one recurrent tumor.
mesh_terms: D000328:Adult; D000368:Aged; D002528:Cerebellar Neoplasms / Q000175:diagnosis; D002530:Cerebellopontine Angle / Q000473:pathology; D003287:Contrast Media; D004428:Ear Neoplasms / Q000175:diagnosis; D005260:Female; D006801:Humans; D007759:Labyrinth Diseases / Q000175:diagnosis; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004369:Pentetic Acid; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D004369:Pentetic Acid