title: Tioconazole 2% cream in the treatment of Trichomonas vaginalis or mixed vaginal infections.
abstract: Twenty patients with documented T. vaginalis infections, six of whom were simultaneously infected with C. albicans and one with G. vaginalis, were treated topically (intravaginally) once daily with 5 g of 2% tioconazole vaginal cream (Trosyd, Pfizer) for 3 consecutive days in an open, non-comparative study. At the first follow-up visit (about 7 days post-treatment), 95% (19/20) of the patients were cured; 95% (18/19) of patients remained cured with respect to the baseline infection at the long-term follow-up (2 months post-treatment) visit, and one patient had a reinfection or relapse with T. vaginalis. Only one patient reported a side-effect, a mild vaginal burning which disappeared with continued treatment. It was concluded that tioconazole 2% vaginal cream is safe and effective for the treatment of T. vaginalis and mixed vaginal infections.
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002181:Candidiasis, Vulvovaginal / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006194:Gardnerella vaginalis; D006192:Haemophilus Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D014247:Trichomonas Vaginitis / Q000150:complications / Q000188:drug therapy*; D014623:Vaginal Diseases / Q000188:drug therapy*
chemical_list: D007093:Imidazoles; C020527:tioconazole