Regeneration of spleen colony-forming cells and granulocyte-monocyte progenitors in T-cell deprived mice treated with cyclophosphamide.
The role of T cells in regeneration of CFU-S(d8) and GM-CFU was investigated in adult Cy treated mice. CBA mice were deprived of T cells by adult thymectomy and irradiation (TIR) and treated with 200 mg/kg Cy. The type of CFU-S(d8) and GM-CFU regeneration curve after Cy was not different from that found in nonthymectomized, irradiated (NIR) mice. The activity of a stimulator of CFU-S(d8) proliferation was increased to the same degree in the bone marrow of both TIR and NIR mice. However CFU-S(d8) recovered to a higher level in TIR than in NIR mice. The results presented demonstrate that T-cell depletion in adult mice influences CFU-S(d8) growth.
D000818:Animals; D002455:Cell Division; D003114:Colony-Forming Units Assay; D003520:Cyclophosphamide / Q000494:pharmacology*; D006098:Granulocytes / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA; D012038:Regeneration; D013154:Spleen / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*; D013934:Thymectomy
D003520:Cyclophosphamide