title: Arachidonic acid metabolites in the pathophysiology of thrombocytopenia and haemorrhage in acute African swine fever.
abstract: Changes in the production of proaggregatory (thromboxane A2 and prostaglandin E2) and antiaggregatory (prostacyclin) prostaglandins by blood platelets, macrophages and endothelial cells during acute African swine fever caused by both a highly virulent virus and a less virulent virus were studied. No impairment in thromboxane A2 release by either platelets or macrophages could be detected but prostacyclin production by the endothelium was impaired. There was also a significant increase in prostaglandin E2 release by macrophages at the time when thrombocytopenia was most marked. However, the early event that causes primary aggregation remains obscure.
mesh_terms: D000357:African Swine Fever / Q000097:blood / Q000503:physiopathology*; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D001777:Blood Coagulation; D001792:Blood Platelets / Q000378:metabolism; D015232:Dinoprostone; D004727:Endothelium / Q000378:metabolism; D006400:Hematocrit / Q000662:veterinary; D006470:Hemorrhage / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D008264:Macrophages / Q000378:metabolism; D010974:Platelet Aggregation; D010979:Platelet Function Tests / Q000662:veterinary; D011458:Prostaglandins E / Q000097:blood / Q000378:metabolism; D013552:Swine; D013553:Swine Diseases / Q000097:blood / Q000503:physiopathology*; D013921:Thrombocytopenia / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D013929:Thromboxane B2 / Q000097:blood / Q000378:metabolism
chemical_list: D001095:Arachidonic Acids; D011458:Prostaglandins E; D013929:Thromboxane B2; D015232:Dinoprostone