Ventilatory effects of propofol during induction of anaesthesia. Comparison with thiopentone.
The ventilatory effects of induction of anaesthesia with either propofol 2.5 mg/kg or thiopentone 4.0 mg/kg have been observed in patients premedicated with either atropine alone or papaveretum and hyoscine. Induction of anaesthesia with propofol was accompanied by a greater degree of ventilatory depression which was of longer duration than following thiopentone. The effect was accentuated by the opioid premedication.
D000328:Adult; D000777:Anesthetics / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D003864:Depression, Chemical; D004357:Drug Synergism; D005260:Female; D006801:Humans; D009892:Opium / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology*; D011229:Preanesthetic Medication; D015742:Propofol; D012119:Respiration / Q000187:drug effects*; D012601:Scopolamine / Q000494:pharmacology; D013874:Thiopental / Q000494:pharmacology*
D000777:Anesthetics; D010636:Phenols; D001285:Atropine; D009892:Opium; D012601:Scopolamine; D013874:Thiopental; D015742:Propofol