title: Endogenous pyrogen/interleukin-1 production in aged rats.
abstract: The effect of aging on the ability of macrophages to produce endogenous pyrogen/interleukin-1 (EP/IL-1) was tested in 13 young adult (2-3 mo) and 13 aged (24-26 mo) Fischer rats using a febrile response assay. Peritoneal macrophages from aged rats produced EP/IL-1 as well as young adult rats. Decreased production of EP/Il-1 does not appear to explain the diminished febrile response seen in the elderly.
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D005334:Fever / Q000139:chemically induced; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000633:toxicity; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D007375:Interleukin-1