In pregnancy, corticotropin-releasing-factor in maternal blood and amniotic fluid correlates with the gestational age.
Immunoreactive corticotropin-releasing factor (IR-CRF) was measured in maternal plasma and amniotic fluid. Significant correlations between both IR-CRF levels in maternal plasma (p less than 0.001, n = 82, r = 0.458) and IR-CRF levels in amniotic fluid (p less than 0.001, n = 81, r = 0.424) and the gestational age were seen. We conclude that CRF may regulate the ACTH cortisol axis in the placenta-fetus unit.
D000653:Amniotic Fluid / Q000378:metabolism*; D003346:Corticotropin-Releasing Hormone / Q000097:blood / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy / Q000378:metabolism*
D003346:Corticotropin-Releasing Hormone