title: Further investigations on the significance of a plasma coagulation-accelerating factor in glomerular disease.
abstract: The prevalence of the coagulation acceleration factor (CAF) in patients with renal disease (predominantly glomerulonephritis) has been investigated. The relationship between the activated partial thromboplastin time, F.VIII:C/vWf, prekallikrein, plasminogen and the pathogenesis of glomerulonephritis was also investigated. One hundred and seventeen patients were entered into the study on the basis of admission for renal biopsy. Thirteen percent of the patients showed evidence for CAF and 15% of patients were found to have reduced levels of plasma prekallikrein; however, no correlation was found between any of the variables measured and the type, activity or progression of glomerular disease in these patients.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D005342:Fibrinolysis; D005921:Glomerulonephritis / Q000097:blood / Q000503:physiopathology; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D010958:Plasminogen / Q000032:analysis; D011288:Prekallikrein / Q000032:analysis
chemical_list: D010958:Plasminogen; D011288:Prekallikrein