Familial aggregation in noncirrhotic portal fibrosis: a report of four families.
Noncirrhotic portal fibrosis is a common cause of portal hypertension in India. We report four families with more than one member afflicted with this disorder. Six of the seven (85.5%) patients in whom HLA studies were carried out were HLA-DR 3 positive. The possibility of an immunogenetic basis of noncirrhotic portal fibrosis should be investigated further.
D000293:Adolescent; D000328:Adult; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis; D015803:HLA-DR3 Antigen; D006801:Humans; D007194:India; D008103:Liver Cirrhosis / Q000235:genetics* / Q000276:immunology; D008297:Male; D010375:Pedigree
D006680:HLA Antigens; D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen