title: Changes in intraocular pressure associated with the administration of propofol.
abstract: The effect of propofol on intraocular pressure (IOP) was measured in 25 patients presenting for elective non-ophthalmological surgery when propofol was used for the induction and maintenance of anaesthesia (together with 67% nitrous oxide in oxygen, and vecuronium). Normocapnia was maintained. After induction of anaesthesia, intraocular pressure was significantly lower than the baseline value; during maintenance IOP never exceeded the preinduction value. There was a temporary decrease in arterial pressure after induction. In nine patients a cutaneous flush was observed and in seven patients there was discomfort on injection. Spontaneous movement in 20% and hiccup in 12% of the patients were observed at the time of tracheal intubation.
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D000777:Anesthetics / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000009:adverse effects / Q000494:pharmacology*; D015742:Propofol; D013997:Time Factors
chemical_list: D000777:Anesthetics; D010636:Phenols; D015742:Propofol