Constitutional Robertsonian T(15;22) in Ph-positive CML.
Chromosome studies in a phenotypically normal 40-year-old man with Philadelphia (Ph) chromosome-positive chronic myelocytic leukemia (CML) and a constitutional Robertsonian translocation are reported. The possibility of carriers of Robertsonian translocations having an increased risk to develop Ph-positive CML is mentioned.
D000328:Adult; D002871:Chromosome Banding; D002884:Chromosomes, Human, Pair 15; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic