Sweet's syndrome, acute leukemia, and t(3;5).
We report herein the case of a 36-year-old woman who was diagnosed as having Sweet's syndrome 13 months prior to developing acute myeloid leukemia (FAB type M2). Her bone marrow karyotype was 46,XX,t(3;5)(q21;q31). Translocation t(3;5) has been reported in seven other cases of acute nonlymphocytic leukemia. None of these cases have been associated with Sweet's syndrome.
D000328:Adult; D002871:Chromosome Banding; D002893:Chromosomes, Human, Pair 3; D002895:Chromosomes, Human, Pair 5; D005260:Female; D005334:Fever; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000235:genetics*; D009504:Neutrophils / Q000473:pathology; D012871:Skin Diseases / Q000150:complications / Q000235:genetics*; D013577:Syndrome; D014178:Translocation, Genetic