Study of the DBA/2Ha immunodeficiency: X-chromosome mosaicism and in vivo immunoresponses.
DBA/2Ha mice have an X-chromosome-linked immunodeficiency and lack the receptor to a TRF (T cell replacing factor) on a subpopulation of B cells. Their immunodeficiency is considered to resemble that of CBA/N, another X-chromosome-linked immunodeficiency. To facilitate direct comparisons of the two immunodeficiencies and to study the in vivo manifestations of DBA/2Ha immunodeficiency, we measured phenotypes and functions of B cells of DBA/2Ha mice. We found that the expression of sIgM among B cells is normal in DBA/2Ha mice, heterozygous females equally express both affected and normal B cell subpopulations, and DBA/2Ha mice respond well to a TI-2 antigen (TNP-Ficoll) and a polyclonal activator (LPS). Unlike CBA/N, DBA/2Ha mice demonstrate very little in vivo immunodeficiencies.
D000818:Animals; D000917:Antibody Formation; D000954:Antigens, Surface / Q000032:analysis; D005260:Female; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006579:Heterozygote; D007074:Immunoglobulin G / Q000096:biosynthesis; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis; D007153:Immunologic Deficiency Syndromes / Q000235:genetics*; D015848:Interleukin-5; D007378:Interleukins / Q000502:physiology*; D007527:Isoenzymes / Q000235:genetics; D008214:Lymphocytes / Q000502:physiology*; D051379:Mice; D008811:Mice, Inbred DBA / Q000235:genetics / Q000276:immunology*; D009030:Mosaicism; D010735:Phosphoglycerate Kinase / Q000235:genetics; D011971:Receptors, Immunologic / Q000502:physiology*; D014960:X Chromosome / Q000502:physiology*
D000954:Antigens, Surface; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D015848:Interleukin-5; D007378:Interleukins; D007527:Isoenzymes; D011971:Receptors, Immunologic; D010735:Phosphoglycerate Kinase