Different early-signaling pathways coupled to transcriptional and posttranscriptional regulation of gene expression during mitogenic activation of T lymphocytes.
Two categories of mitogen-induced mRNAs were defined in T lymphocytes. The type 1 messages (represented by c-myc) were regulated transcriptionally, and their expression seemed to be calmodulin dependent. The type 2 messages (ornithine decarboxylase, actin, and alpha-tubulin) were regulated posttranscriptionally through activation of protein kinase C.
D000818:Animals; D002417:Cattle; D002453:Cell Cycle; D003208:Concanavalin A; D005786:Gene Expression Regulation; D007700:Kinetics; D008213:Lymphocyte Activation; D011493:Protein Kinase C / Q000378:metabolism; D011519:Proto-Oncogenes; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000235:genetics; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D014158:Transcription, Genetic
D012333:RNA, Messenger; D003208:Concanavalin A; D011493:Protein Kinase C