title: Colonization of the human oral cavity by a Streptococcus mutans mutant producing increased bacteriocin.
abstract: Streptococcus mutans strain JH1005 is a mutant that produces levels of bacteriocin activity three-fold-elevated than those produced by its parent, JH1001. A single infection regimen with JH1005 was found to result in persistent colonization of the teeth of all three adult subjects tested. This is a significant improvement over JH1001, which required multiple exposures in order to colonize the teeth of humans reliably. The levels of total cultivable bacteria and indigenous S. sanguis were not affected by JH1005 colonization. In two of the three subjects, total (indigenous plus JH1005) S. mutans levels were significantly decreased. The results provide additional support for the role of bacteriocin production as an ecological determinant in colonization by S. mutans. They also indicate that a practical regimen for infection by an effector strain might be achieved for use in the replacement therapy of dental caries.
mesh_terms: D000328:Adult; D001430:Bacteriocins / Q000378:metabolism*; D006801:Humans; D008297:Male; D009055:Mouth / Q000382:microbiology*; D009154:Mutation; D012463:Saliva / Q000382:microbiology; D013295:Streptococcus mutans / Q000145:classification / Q000254:growth & development* / Q000302:isolation & purification / Q000378:metabolism; D013298:Streptococcus sanguis / Q000302:isolation & purification
chemical_list: D001430:Bacteriocins