[Formation of specific IgG antibodies in l-asparaginase treatment. Distribution of IgG subclasses].
During l-Asparaginase (l-Asp) treatment the development of specific antibodies of IgG isotype is frequently observed. In most instances elevated IgG antibodies to l-Asp activate the complement system and induce allergic reactions following l-Asp infusion. However, in some cases no adverse reactions and no activation of complement are noticed, despite the presence of elevated anti-l-Asp levels. We studied the development of specific IgG antibodies to l-Asp in different subclasses in 12 children who had produced high levels of specific IgG. Results showed that all patients had elevated levels of IgG1. In 5 cases we were able to demonstrate the development of specific IgG3 antibodies and in 1 case of IgG4 antibody. Patients with high levels of IgG3 (above 100 AU) had the highest risk for subsequent anaphylaxis. Thus, subclass-specific determination of antibodies to l-Asparaginase might improve the estimation of the risk of anaphylaxis prior to 1-Asp infusions.
D000293:Adolescent; D000918:Antibody Specificity; D001215:Asparaginase / Q000276:immunology* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D008297:Male; D012074:Remission Induction; D012306:Risk
D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D001215:Asparaginase
Bildung spezifischer IgG-Antikörper unter l-Asparaginasebehandlung. Verteilung der IgG-Subklassen.