[Biochemical polymorphic systems in the migrant population of northeastern USSR. VI. Genetic structure of patients in separate nosological groups].
Genotype frequency distribution for a number of polymorphic loci in patients differs significantly in different nosologic groups, in relation to each other and to a sample of healthy individuals. Genetic structure specificity of each nosologic group and different trends of genetic frequency variations, in relation to the sample of healthy individuals, leads to considerable decrease in genetic differences between the united group of pathology and healthy individuals' sample. Spatial differentiation of genetic structure of separate nosologic groups and healthy individuals' sample also confirms genetic isolation of each of these groups and, at the same time, reveals clearly nonspecific biological resistance of human organism.
D004198:Disease Susceptibility; D004641:Emigration and Immigration; D005819:Genetic Markers; D005826:Genetics, Medical; D006801:Humans; D011110:Polymorphism, Genetic; D012800:Siberia
D005819:Genetic Markers
Biokhimicheskie polimorfnye sistemy v populiatsii prishlykh zhiteleĭ Severo-Vostoka SSSR. Soobshchenie VI. Osobennosti geneticheskoĭ struktury bol'nykh po otdel'nym nozologicheskim gruppam.