Granules of cytolytic T-lymphocytes contain two serine esterases.
Cytoplasmic granules from cytolytic T-lymphocytes (CTL) contain two proteins which react with the serine esterase-specific affinity label diisopropylfluorophosphate (DFP). One of these is a trypsin-like esterase which consists of two disulfide-linked 35-kd subunits. The other consists of a single 29-kd chain. Both molecules are induced concomitantly with cytolytic activity and perforin activity in a CTL-derived T-cell hybrid.
D000818:Animals; D002460:Cell Line; D003594:Cytoplasmic Granules / Q000201:enzymology*; D004950:Esterases / Q000302:isolation & purification / Q000378:metabolism*; D006461:Hemolysis; D006863:Hydrogen-Ion Concentration; D007531:Isoflurophate / Q000494:pharmacology; D007700:Kinetics; D051379:Mice; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D007531:Isoflurophate; D004950:Esterases; C022635:serine esterase