Phenotypic heterogeneity in three cases of lymphoid malignancy with chromosomal translocations in 14q11.
Lymphoid malignancies bearing translocations involving the region 14q11 are thought to have a T-cell phenotype because their pathogenesis is postulated to involve the aberrant juxtaposition of DNA sequences active in T-cell differentiation (T-cell antigen receptor genes) and proto-oncogenes. We present here three lymphoid malignancies with translocations involving 14q11. Although one had a T-cell phenotype, the other two had B-cell lineage phenotypes. Our findings confirm that not all lymphoid malignancies with translocations involving 14q11 represent T-cell clonal expansions.
D000951:Antigens, Neoplasm / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002901:Chromosomes, Human, 13-15; D005260:Female; D006801:Humans; D007621:Karyotyping; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology; D008297:Male; D010641:Phenotype; D013601:T-Lymphocytes / Q000166:cytology; D014178:Translocation, Genetic
D000951:Antigens, Neoplasm