Sterol sulfates in the epididymis; synthesis and possible function in the reproductive process.
Sterol sulfates are present in relatively high concentrations in the male reproductive tract. Cholesteryl sulfate is the major sterol sulfate in the human epididymis while desmosteryl sulfate is the major sterol sulfate in the hamster epididymis. While the testis is the major source of sterol sulfate in the human, the epididymis of the hamster is the source of demosteryl sulfate. This conjugate accumulates along the length of the epididymis and is taken up by the plasma membrane in the acrosomal region of the spermatozoa. Sulfotransferase activity increases along the epididymis and this is due to the actual synthesis of the enzyme. Sterol sulfates are potent and specific inhibitors of the proteolytic enzyme, acrosin. This property could provide protection against the premature release of proteolytic activity within the male reproductive tract. It is proposed that the removal of this inhibition occurs within the female tract via sulfatase activity in order to enable the acrosome reaction and ovum penetration to occur.
D000176:Acrosin / Q000037:antagonists & inhibitors; D000177:Acrosome / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002788:Cholesterol Esters / Q000096:biosynthesis / Q000502:physiology*; D006224:Cricetinae; D003897:Desmosterol / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000502:physiology; D004822:Epididymis / Q000378:metabolism; D005260:Female; D005836:Genitalia, Female / Q000201:enzymology; D006801:Humans; D008297:Male; D051381:Rats; D012756:Sheep; D013084:Sperm-Ovum Interactions; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000378:metabolism; D015238:Sulfotransferases; D013466:Sulfurtransferases / Q000378:metabolism*
D002788:Cholesterol Esters; D003897:Desmosterol; C021005:desmosterol sulfate; D013466:Sulfurtransferases; D015238:Sulfotransferases; C044251:steroid sulfotransferase; D013429:Sulfatases; D043266:Steryl-Sulfatase; D000176:Acrosin; C007045:cholesteryl sulfate