The adenylate cyclase response to parathyroid hormone in fetal lung fibroblasts is enhanced by cortisol.
Parathyroid hormone (PTH, less than 10(-8) M) stimulated adenylate cyclase in fibroblasts, but not epithelial cells, isolated from fetal rat lung. In contrast to osteosarcoma cells (UMR 106), the response of fibroblasts to PTH was increased by pretreatment with cortisol (less than 10(-8)-10(-7) M).
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D005333:Fetus / Q000201:enzymology; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000196:embryology / Q000201:enzymology*; D012516:Osteosarcoma / Q000201:enzymology; D010281:Parathyroid Hormone / Q000502:physiology*; D051381:Rats
D010281:Parathyroid Hormone; D000262:Adenylyl Cyclases; D006854:Hydrocortisone