title: Remarks on the therapy of depressions with amine precursors.
abstract: The therapy of depressions with amine precursors is based on the hypothesis of an amine deficiency in depression. A brief review of different trials with these substances is given. However, the therapeutic effects achieved were not satisfactory, although treatment with 5-HT or with amine precursors combined with lithium or MAO-inhibitors seemed to be more successful. Furthermore, the difficulties in interpreting these somewhat disappointing results is pointed out.
mesh_terms: D006916:5-Hydroxytryptophan / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use; D012701:Serotonin / Q000172:deficiency; D014364:Tryptophan / Q000627:therapeutic use*
chemical_list: D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; D014364:Tryptophan; D008094:Lithium; D006916:5-Hydroxytryptophan