A new translocation, t(10;14)(q24;q11), in T cell neoplasia.
Four cases of T cell neoplasia are reported: three presenting as T cell acute lymphoblastic leukemia and one presenting in the leukemic phase of a T cell lymphoma. In all cases, the cells of the leukemic clone were characterized by an identical cytogenetic abnormality. This abnormality was a unique reciprocal translocation involving chromosomes 10 and 14. The breakpoint in chromosome 14 was in band q11, coincident with the assigned locus of the alpha-chain gene of the T cell antigen receptor. The breakpoint in chromosome 10 was in band q24, a region reported to include the locus of the terminal deoxynucleotidyltransferase (TdT) gene. Our observations suggest that translocation t(10;14)(q24;q11) is specific for T cell neoplasia and that a gene in chromosomal band 10q24, possibly the TdT gene, plays an important role in T cell neoplasia when its expression or coding sequence is altered by aberrant recombination involving a T cell antigen receptor gene.
D000328:Adult; D002648:Child; D002675:Child, Preschool; D002901:Chromosomes, Human, 13-15 / Q000473:pathology*; D002906:Chromosomes, Human, 6-12 and X / Q000473:pathology*; D005260:Female; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000473:pathology; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D013601:T-Lymphocytes / Q000473:pathology*; D014178:Translocation, Genetic