The human bladder carcinoma line T-24 secretes a human B-cell differentiation factor.
The effect of a B-cell differentiation factor (BCDF) found in the supernatant of the human bladder carcinoma cell line T-24 (T-24.BCDF) was assessed using the human lymphoblastoid line CESS (Muraguchi et al., 1981) and TPA-stimulated human B-CLL B cells. This T-24.BCDF was shown to cause both these cell types to secrete immunoglobulin, and therefore indicates that culture supernatants from this bladder carcinoma line contain a potent differentiation factor for human B cells.
D002460:Cell Line; D006133:Growth Substances / Q000096:biosynthesis*; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D015847:Interleukin-4; D007945:Leukemia, Lymphoid / Q000276:immunology; D008222:Lymphokines / Q000096:biosynthesis*; D001749:Urinary Bladder Neoplasms / Q000276:immunology*
D006133:Growth Substances; D007136:Immunoglobulins; D008222:Lymphokines; D015847:Interleukin-4