The bulk of endogenously produced IgG2a is eliminated from the serum of adult C57BL/6 mice with a half-life of 6-8 days.
The concentration of IgG2a in the serum of C57BL/6 mice suppressed for the production of IgG2a was measured over a period of 3 months after suppression. The elimination of a minimum of 96% of the endogenous IgG2a molecules from the serum follows an exponential decay with a half-life of 6-8 days. A monoclonal IgG2a antibody injected into suppressed or normal mice is eliminated from the serum in the same fashion. We conclude that there are few, if any, "long-lived" IgG2a molecules present in the serum of C57BL/6 mice under physiological conditions.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000637:transplantation; D006207:Half-Life; D007074:Immunoglobulin G / Q000276:immunology / Q000378:metabolism*; D007165:Immunosuppression Therapy; D051379:Mice; D008810:Mice, Inbred C57BL / Q000097:blood / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation; D013997:Time Factors
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; C048844:anti-IgG