Production of immunoglobulin M (IgM) autoantibodies to IgG in rabbits inoculated with Mycoplasma salivarium cells grown in medium supplemented with rabbit serum.
Mycoplasma salivarium cells propagated in PPLO broth (Difco Laboratories, Detroit, Mich.) supplemented with rabbit serum (10% [vol/vol]) and harvested by centrifugation were shown to contain rabbit immunoglobulin G (IgG) (approximately 4 to 10% of total cell proteins) and to produce IgM autoantibodies to IgG when inoculated into rabbits.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis*; D001323:Autoantibodies / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D009174:Mycoplasma / Q000276:immunology*; D010510:Periodontal Diseases / Q000276:immunology* / Q000382:microbiology; D011817:Rabbits
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M