Hemoperfusion and immunocorrection in acute stage of severely burned patients.
The goal of this study was to explore the therapeutic effect of hemoperfusion and immunocorrection therapy in acute period of burn disease in severely injured patients. Hemoperfusion was performed in severely burned patients 1-3 times in the period from the 2nd to 10th day. The hemoperfusion procedures in severely burned patients were combined with immunocorrecting therapy. To prevent the development of septic complications in the early periods after the injury the patients were treated with passive immunotherapy supplemented with immunocorrecting substances. The patients were divided into two groups. The first group (26 persons) included patients treated with hemoperfusion followed by immunocorrection. The second group (11 persons) consisted of patients treated according to routine schemes. The studies carried out show that hemoperfusion with subsequent immunocorrection produced normalizing effect on indices of cellular and humoral immunity in severely burned patients. The efficacy of detoxication is attained both owing to blood depuration and due to detoxifying influence of directional effect immunoglobulins.
D001402:B-Lymphocytes / Q000276:immunology; D002056:Burns / Q000628:therapy*; D006464:Hemoperfusion; D006801:Humans; D007116:Immunization, Passive; D013601:T-Lymphocytes / Q000276:immunology