Immunomodulatory and therapeutic properties of alkyl lysophospholipids in mice.
This paper describes the immunomodulatory and therapeutic properties of the alkyl lysophospholipids [ALP; 1-O-octadecyl-2-O-rac-glycero-3-phosphocholine (ET-18-OCH3)]. ALP was able to activate macrophages both in vitro and in vivo as well as to act as an immunoadjuvant for syngeneic tumor vaccines. However, ALP appeared to be transferred, at least in part, to the macrophage membrane, and some of the tumoricidal macrophage-activating properties seem to be associated with the direct cytotoxic effect of membrane-released ALP. ALP also had some therapeutic activity for experimental and spontaneous metastases, requiring administration three but not two times weekly at near-toxic doses; this suggests that at least some of its therapeutic activity is due to direct cytotoxicity.
D000818:Animals; D000970:Antineoplastic Agents / Q000276:immunology* / Q000627:therapeutic use; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D004305:Dose-Response Relationship, Drug; D007694:Killer Cells, Natural / Q000187:drug effects; D008246:Lysophospholipids / Q000276:immunology* / Q000627:therapeutic use / Q000633:toxicity; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D010742:Phospholipid Ethers / Q000276:immunology* / Q000627:therapeutic use / Q000633:toxicity; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D000970:Antineoplastic Agents; D008246:Lysophospholipids; D010742:Phospholipid Ethers; C026659:edelfosine