title: Acute lesions induced by alpha-irradiation of intestine after plutonium gavage of neonatal rats.
abstract: After gavage of two-day-old rats with 238Pu(IV)-citrate at 17.4 MBq/kg (122 kBq per animal), 45 per cent of the animals died during the second week following ingestion. Histological analysis showed that death was due to acute intestinal lesions caused by alpha-radiation that resulted in denudation of the ileum. Under these experimental conditions, the total alpha-dose delivered to the ileal wall and its contents was estimated at 150 Gy. No acute lesions were observed after gavage of two-day-old rats with Pu-citrate at 5.3 MBq/kg.
mesh_terms: D000208:Acute Disease; D000512:Alpha Particles / Q000009:adverse effects*; D000818:Animals; D000831:Animals, Newborn; D005766:Gastrointestinal Contents / Q000528:radiation effects; D005767:Gastrointestinal Diseases / Q000209:etiology* / Q000473:pathology; D007082:Ileum / Q000473:pathology / Q000528:radiation effects*; D007421:Intestine, Small / Q000473:pathology / Q000528:radiation effects; D007441:Intubation, Gastrointestinal; D011005:Plutonium / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011005:Plutonium