Joint inflammation in mice induced by a MT4+ Lyt-2- T cell clone. Characteristics and the induction of flare-up reactions.
Joint inflammations were induced in mice by cloned MT4+ Lyt-2- T cells specific for methylated bovine serum albumin. This was done either by intra-articular or by i.v. administration of the cloned T cells, together with local injection of the antigen. Local rechallenge with methylated bovine serum albumin several weeks after waning of the joint inflammation caused a flare-up reaction. The inflammations were quantified by a 99mTc-uptake method and examined histologically. The arthritis induced by the cloned T cells showed aspects of a delayed type hypersensitivity reaction characterized by an intense infiltrate which resembles the inflammation in the human rheumatoid joint. The data presented show that joint inflammations can be induced by T cells only and that, after waning, reexposition to the original antigen can induce a flare-up reaction. The data suggest a central role of T cells in the induction and the exacerbations observed in rheumatoid arthritis.
D000818:Animals; D000941:Antigens / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000473:pathology; D002999:Clone Cells / Q000276:immunology / Q000637:transplantation; D004195:Disease Models, Animal; D006968:Hypersensitivity, Delayed / Q000276:immunology / Q000473:pathology; D007116:Immunization, Passive; D007249:Inflammation; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D012710:Serum Albumin, Bovine / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation
D000941:Antigens; C029180:methylated bovine serum albumin; D012710:Serum Albumin, Bovine