title: Lactoferrin, C-reactive protein, alpha-1-antitrypsin and immunoglobulin GA in cerebrospinal fluid in meningitis.
abstract: Cerebrospinal fluid measurements of lactoferrin and alpha-1-antitrypsin showed significant elevation in bacterial meningitis in children. 8 of 10 lactoferrin values and 6 of 11 alpha-1-antitrypsin values were above the upper range of controls. Both proteins correlated well with the total number of leukocytes in the cerebrospinal fluid. C-reactive protein, measured by either agglutination or radial immunodiffusion in the cerebrospinal fluid, failed to demonstrate any usefulness in diagnosing bacterial meningitis. Neither elevated serum C-reactive protein in cases of bacterial meningitis, nor sepsis, gave detectable concentrations of C-reactive protein in the cerebrospinal fluid.
mesh_terms: D000293:Adolescent; D002097:C-Reactive Protein / Q000134:cerebrospinal fluid*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D007223:Infant; D007781:Lactoferrin / Q000134:cerebrospinal fluid*; D007782:Lactoglobulins / Q000134:cerebrospinal fluid*; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000276:immunology; D000515:alpha 1-Antitrypsin / Q000134:cerebrospinal fluid*
chemical_list: D007074:Immunoglobulin G; D007782:Lactoglobulins; D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein; D007781:Lactoferrin