Expression of the c-myc proto-oncogene in growth stimulated porcine thyroid follicle cells.
In the present investigation the expression of c-myc in porcine thyroid follicle cells following the incubation with TSH or EGF was studied. EGF did not only have a mitotic effect on thyroid follicles but also increased c-myc mRNA. The increase in c-myc RNA is an early event in EGF stimulated thyroid cells. TSH had no effect on c-myc RNA levels of porcine thyroid cells. EGF-binding and sensitization to the mitotic activity of EGF, however, is increased by TSH. While TSH stimulates cAMP production and functional activity but not growth or c-myc expression of porcine thyroid cells, EGF produces cell division accompanied with c-myc expression.
D000818:Animals; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000494:pharmacology; D008938:Mitosis / Q000187:drug effects; D011519:Proto-Oncogenes; D013552:Swine; D013961:Thyroid Gland / Q000166:cytology* / Q000187:drug effects; D013972:Thyrotropin / Q000494:pharmacology
D004815:Epidermal Growth Factor; D013972:Thyrotropin