[Active specific immunotherapy in patients with lung cancer following tumor removal].
Total levels of lymphocytes, T-lymphocytes as well as concentrations of their theophylline-sensitive and theophylline-resistant fractions were measured in 63 lung cancer patients, 5 cases of benign pulmonary tumors and 16 healthy controls. A significant decrease in T-lymphocyte and theophylline-resistant lymphocyte levels was registered in lung cancer patients. Forty-six radically-operated patients received 3 subcutaneous injections of an autologous tumor cell vaccine. The procedure was free of complications. It was followed by an improvement in cell-mediated immunity and produced a higher 2-year survival rate.
D000230:Adenocarcinoma / Q000276:immunology / Q000401:mortality / Q000601:surgery / Q000628:therapy; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000401:mortality / Q000601:surgery / Q000628:therapy; D002469:Cell Separation; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*; D013806:Theophylline / Q000494:pharmacology; D014611:Vaccination
D000951:Antigens, Neoplasm; D013806:Theophylline
Aktivnaia spetsificheskaia immunoterapiia bol'nykh rakom legkogo posle udaleniia opukholi.