Effects of corticotropin releasing factor and sauvagine on social behavior of isolated mice.
Corticotropin releasing factor (CRF) and sauvagine (SVG) when injected ICV both reduced aggressive behavior and sociability while increasing defensive behavior in isolated DBA/2 mice interacting with a group-housed intruder. SVG was more effective than CRF in producing such behavioral effects. These results add further evidence to the similarity between CRF and SVG, and are discussed in terms of the involvement of these peptides in emotional reactivity in the laboratory mouse.
D000374:Aggression / Q000187:drug effects; D029845:Amphibian Proteins; D000818:Animals; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D036361:Peptide Hormones; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D012919:Social Behavior; D012934:Social Isolation; D014665:Vasodilator Agents / Q000494:pharmacology
D029845:Amphibian Proteins; D036361:Peptide Hormones; D010455:Peptides; D014665:Vasodilator Agents; C025727:sauvagine; D003346:Corticotropin-Releasing Hormone