BALB/c and CBA mice differ in the subtype of T cell involved in Moloney murine leukemia virus-induced lymphomas.
Subsets of T cells can be recognized by presence or absence of terminal deoxynucleotidyl transferase (TdT) or 20 alpha-hydroxysteriod dehydrogenase (20 alpha SDH) activity. By use of these enzyme markers Moloney murine leukemia virus (M-MuLV)-induced lymphomas were shown to involve different T-cell subtypes. In the present paper we show that the genotype of the mouse has a strong influence on the subtype of T cell involved in lymphoma. BALB/c mice preferentially develop 20 alpha SDH-positive lymphomas, whereas CBA lymphomas often have the TdT phenotype. Comparison of the 20 alpha SDH activity of normal bone marrow cells showed that BALB/c mice have higher enzyme levels than CBA mice. The relative availability of a certain type of cell at a critical early step in leukemogenesis may thus influence lymphoma type.
D015089:20-Hydroxysteroid Dehydrogenases / Q000032:analysis*; D000818:Animals; D001853:Bone Marrow / Q000201:enzymology; D004253:DNA Nucleotidylexotransferase / Q000032:analysis*; D004254:DNA Nucleotidyltransferases / Q000032:analysis*; D008223:Lymphoma / Q000201:enzymology* / Q000235:genetics / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008979:Moloney murine leukemia virus; D013045:Species Specificity; D013154:Spleen / Q000201:enzymology; D013601:T-Lymphocytes / Q000145:classification*; D013950:Thymus Gland / Q000201:enzymology; D014766:Viremia / Q000276:immunology
D015089:20-Hydroxysteroid Dehydrogenases; D004254:DNA Nucleotidyltransferases; D004253:DNA Nucleotidylexotransferase