Characterization of lectin-binding lymphocytes in goats with caseous lymphadenitis.
Numbers of lymphoid cells bearing markers for peanut agglutinin, wheat germ agglutinin, and anti-immunoglobulin G in healthy goats and in goats with caseous lymphadenitis were determined by use of immunofluorescent techniques. Results indicated that, when compared with healthy goats, diseased goats had normal numbers of anti-immunoglobulin G-positive cells (B cells), had significantly reduced numbers of peanut agglutinin-positive cells (T cells), and had fewer cells with receptor sites for Lens culinaris agglutinin and concanavalin A. Compared with healthy goats, numbers of peanut agglutinin-positive cells in goats with caseous lymphadenitis indicated that the goats may have had a compromised cell-mediated immunity.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis / Q000276:immunology; D003354:Corynebacterium Infections / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D005260:Female; D006041:Goats / Q000097:blood* / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D037102:Lectins / Q000378:metabolism*; D008199:Lymphadenitis / Q000097:blood / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D037102:Lectins