title: [Comparative characteristics of the catalytic properties of platelet adenosine deaminase in normal states and in chronic myeloid leukemia].
abstract: Properties of adenosine deaminase from thrombocytes of healthy persons and of patients with chronic myeloleukosis were studied in presence of various structural analogues of purines and metal ions as well as at various temperature. Catalytic properties of the enzyme in thrombocytes of patients with chronic myeloleukosis were distinct from those of thrombocytes of healthy donors. These differences in the enzymatic properties (contrary to standard estimation of the enzyme activity) might be used both as a criterion of adenosine deaminase anomalies and for detection of the initial steps of the disease.
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood*; D058892:Adenosine Deaminase Inhibitors; D001792:Blood Platelets / Q000201:enzymology*; D002384:Catalysis; D004795:Enzyme Stability; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000201:enzymology*; D009700:Nucleoside Deaminases / Q000097:blood*; D013379:Substrate Specificity
chemical_list: D058892:Adenosine Deaminase Inhibitors; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase
vernacular_title: Sravnitel'naia kharakteristika kataliticheskikh svoĭstv adenozindezaminazy trombotsitov v norme i pri khronicheskom mieloleĭkoze.