A novel muramyl peptide derivative stimulates tumoricidal activity of macrophages and antibody production by B cells.
A novel analog of MDP, the 3'-iodo-4'-azido-L-phenylalanine methyl ester derivative of N-acetyl-L-alanyl-D-isoglutamine, has been prepared. This compound is capable of activating macrophages to the tumoricidal state and increasing the specific immune response of B cells. It thus appears to exhibit similar biological activities to MDP. Moreover, this compound is of potential interest for receptor photolabelling studies.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D005620:Freund's Adjuvant; D007111:Immunity, Cellular / Q000187:drug effects; D008262:Macrophage Activation / Q000187:drug effects; D009374:Neoplasms, Experimental / Q000276:immunology*; D051381:Rats; D013154:Spleen / Q000276:immunology
C053383:N-acetylmuramyl-alanyl-isoglutaminyl-(3'-iodo-4'-azidophenylalanine) methyl ester; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D005620:Freund's Adjuvant