title: Effect of acute and chronic ethanol administration in rats on PGE2 formation in microsomes from stomach and small intestine.
abstract: Prostaglandin E2 formation and content has been measured in the stomach and small intestine of rats after acute and chronic ethanol ingestion. Chronic ethanol administration for 6 and 12 weeks inhibits PGE2 synthesis and reduces PGE2 content (12 weeks) in all parts of the upper gastrointestinal tract, while after ethanol ingestion up to 1 week PGE2 synthesis is decreased only in the stomach.
mesh_terms: D000818:Animals; D015232:Dinoprostone; D004386:Duodenum / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects*; D008297:Male; D008861:Microsomes / Q000187:drug effects* / Q000378:metabolism; D011458:Prostaglandins E / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects*
chemical_list: D011458:Prostaglandins E; D000431:Ethanol; D015232:Dinoprostone