Uveoretinitis and pinealitis induced by immunization with interphotoreceptor retinoid-binding protein.
Rats immunized with microgram amounts of interphotoreceptor retinoid-binding protein (IRBP), a glycoprotein which localizes specifically in the eye and pineal gland, developed uveoretinitis and pinealitis. The severity and onset of changes were found to be dose-related and to be enhanced by B. pertussis bacteria. In general, the inflammatory changes induced by IRBP resembled those provoked by S-antigen (S-Ag), but significant differences were noted between the two diseases. The possible usefulness of the new experimental autoimmune disease is discussed.
D000818:Animals; D004195:Disease Models, Animal; D004660:Encephalitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D005123:Eye / Q000473:pathology; D005136:Eye Proteins; D008297:Male; D009928:Organ Specificity; D010870:Pineal Gland / Q000276:immunology* / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D012173:Retinitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D012177:Retinol-Binding Proteins / Q000276:immunology*; D014605:Uveitis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D000099214:Retinol-Binding Proteins, Interstitial
D005136:Eye Proteins; D012177:Retinol-Binding Proteins; D000099214:Retinol-Binding Proteins, Interstitial