In vitro comparative study of RU 28965 against organisms from oral and vaginal flora.
The Authors studied the activity of RU 28965, a new macrolide antibiotic, in comparison whith erytromycin, josamycin, miocamycin, ampicillin and rifampicin against oral streptococci (45 strains), coryneform bacteria (23 strains) and G. vaginalis (15 strains). Minimum inhibitory concentrations (MIC), minimum bactericidal concentrations (MBC) and the effect of inoculum size on MICs were determined. RU 28965 showed better activity than the other macrolides. The MICs of RU 28965 were eightfold higher than the corresponding MICs. The MICs of RU 28965 showed up to 10 fold increase by increasing the inoculum density from 10(3) to 10(7) CFU/ml.
D000667:Ampicillin / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D006194:Gardnerella vaginalis / Q000187:drug effects; D006801:Humans; D007933:Leucomycins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015644:Miocamycin; D009153:Mutagens / Q000494:pharmacology; D009960:Oropharynx / Q000382:microbiology*; D012293:Rifampin / Q000494:pharmacology; D013291:Streptococcus / Q000187:drug effects; D014621:Vagina / Q000382:microbiology*
D000998:Antiviral Agents; D007933:Leucomycins; D009153:Mutagens; D015644:Miocamycin; D004917:Erythromycin; D000667:Ampicillin; D012293:Rifampin