Oxicams: relative safety and anti-injury effects in rats.
1 Oxicams have certain distinctive properties, which distinguish them from other arylalkanoic (carboxylic) acids that show anti-inflammatory/analgesic/antipyretic activities. These include: (i) slow rates of metabolism (ii) lesser gastro-irritancy/ulcerogenicity (iii) preventing fever development (iv) some effect on the adaptive responses of the liver to severe inflammation or trauma that compromise normal hormone/xenobiotic metabolism (detoxification). 2 Isoxicam was notably less gastrotoxic than either piroxicam or tenoxicam, when given either orally or parenterally, at equipotent doses in rats.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010894:Piroxicam / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats; D013272:Stomach Diseases / Q000139:chemically induced*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; C013580:isoxicam; C032801:tenoxicam