Effects of antiinflammatory drugs on the release from porcine synovial tissue in vitro of interleukin 1 like cartilage degrading activity.
The effects were studied of antiinflammatory drugs possessing inhibitory effects on (a) cyclooxygenase (CO), (b) cyclooxygenase plus 5-lipoxygenase (CO-LO), (c) 5-lipoxygenase (5-LO) and (d) phospholipase A2 (PLA2) activities, for their actions on the release from porcine synovial tissue in culture of cartilage-degrading ("catabolin" or interleukin-1 like) activity (= CDA). CDA was reduced by CO inhibitors, enhanced by CO-LO and PLA2 inhibitors, and unaffected by 5-LO inhibitors. These results suggest that (a) antiinflammatory drugs may affect synovial production of CDA ascribable to IL-1, according to their properties as inhibitors of arachidonate metabolism, and (b) products of arachidonic acid metabolism may influence production of synovial CDA.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002356:Cartilage / Q000378:metabolism; D002417:Cattle; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000502:physiology*; D053583:Interleukin-1beta; D013552:Swine; D013583:Synovial Membrane / Q000187:drug effects* / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007375:Interleukin-1; D053583:Interleukin-1beta