Immune status of drug abusers.
This study followed 184 drug abusers. Examined in all of them were urinary neopterin levels, HBV, SGOT, and Luestest. Seventy-three percent of IV drug addicts showed elevated neopterin levels reflecting activated cellular immunity. Statistically, no correlation of neopterin levels with, eg, excessive alcohol consumption, duration of drug abuse, or studied laboratory parameters was found. Individuals using cocaine revealed higher neopterin levels than those not doing so. Twenty-one of twenty-two patients with no parenteral drug use had normal neopterin excretion. In 34 drug detoxification patients, we examined in addition: T-lymphocyte subsets (T4/T8 ratio) and serum neopterin levels. Thirty-eight of ninety-four parenteral drug addicts presented with anti-LAV/HTLV-III antibodies (ELISA + Western blot + IFT). Our data demonstrate an activated cellular immune status in parenteral drug addicts that cannot be attributed to LAV/HTLV-III infection in all cases. The development of AIDS seems to depend not only on the exposure to LAV/HTLV-III but also on activated cellular immunity, which is easily assessed by neopterin measurement.
D000914:Antibodies, Viral / Q000276:immunology; D001219:Aspartate Aminotransferases / Q000097:blood; D001708:Biopterins / Q000031:analogs & derivatives / Q000652:urine; D002308:Cardiolipins / Q000097:blood; D005260:Female; D006678:HIV / Q000276:immunology; D015483:HIV Antibodies; D006679:HIV Seropositivity; D006505:Hepatitis / Q000150:complications; D006801:Humans; D008297:Male; D019798:Neopterin; D011329:Prisoners; D019966:Substance-Related Disorders / Q000276:immunology*
D000914:Antibodies, Viral; D002308:Cardiolipins; D015483:HIV Antibodies; D001708:Biopterins; D019798:Neopterin; D001219:Aspartate Aminotransferases