Frequency of HLA antigens in a Brazilian type I diabetic population.
1. Sixty-five Brazilian, patients with type I, insulin-dependent diabetes mellitus (IDDM) and 100 unaffected individuals were typed for HLA-A, -B, -C and DR antigens. 2. A significantly higher frequency of HLA-A2 (48% of the patients versus 21% of the controls), B15 (20% of the controls), DR3 (57% of the patients versus 28% of the controls) and DR4 (54% of the patients versus 23% of the controls) was found for IDDM patients compared to the controls. 3. In contrast, DR2 (11% of the patients versus 31% of the controls) and DR7 (3% of the patients versus 21% of the controls) were lower in diabetics, but the difference was not significant. 4. The data reported here, when compared with those of other studies, emphasize the ethnic variability in HLA-IDDM associations.
D001938:Brazil; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D006680:HLA Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D015802:HLA-DR2 Antigen; D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen; D006801:Humans; D008297:Male
D006680:HLA Antigens; D006684:HLA-DR Antigens; D015802:HLA-DR2 Antigen; D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen