Vitamin E supplementation in hemodialysis patients: effects on peripheral blood mononuclear cells lipid peroxidation and immune response.
Lipid peroxidation and vitamin E levels in peripheral blood mononuclear cells (PBMC) were studied in 10 patients on maintenance hemodialysis. Significant increases of PBMC malonyldialdehyde (MDA) were detected, together with low vitamin E levels. After a fifteen-day-course of parenteral vitamin E supplementation, PBMC MDA reverted to normal values, while PBMC vitamin E levels remained lower than controls. In a parallel study an immunological monitoring was performed in the same patients before and after vitamin E supplementation. NK activity and PHA blastogenesis were not influenced by treatment, while a reduction of the number of OKT8+ lymphocytes were observed after vitamin E therapy. It is tempting to speculate that peroxidative damage of PBMC cell membranes in hemodialysis patients could, by impairing their functionality, influence immune responses and expression of functionally relevant membrane determinants.
D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D007958:Leukocyte Count / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects*; D008054:Lipid Peroxides / Q000097:blood*; D008213:Lymphocyte Activation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology; D006435:Renal Dialysis; D012397:Rosette Formation; D012756:Sheep; D013601:T-Lymphocytes / Q000276:immunology; D014511:Uremia / Q000628:therapy; D014810:Vitamin E / Q000097:blood / Q000494:pharmacology*
D000911:Antibodies, Monoclonal; D008054:Lipid Peroxides; D010835:Phytohemagglutinins; D014810:Vitamin E; D008315:Malondialdehyde