title: Dyspepsia: Therapeutic response as a diagnostic tool.
abstract: Non-ulcer dyspepsia (NUD) is a poorly defined heterogenous condition less well suited for the conventional randomized and placebo controlled parallel type trials. We have designed a multi cross-over model (MCO-model) with the facility of providing information about drug responses in individual patients. A pilot study suggested that the model may identify individual cimetidine responders among patients with dyspepsia. Preliminary findings from an ongoing study in patients with NUD supports the existence of a subgroup of cimetidine responders characterized by gastroesophageal reflux symptoms and possibly an increased basal acid secretion.
mesh_terms: D002927:Cimetidine / Q000627:therapeutic use*; D004415:Dyspepsia / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D005744:Gastric Acid / Q000378:metabolism; D006801:Humans; D010865:Pilot Projects
chemical_list: D002927:Cimetidine