Evidence for an alteration in brainstem cholinergic pathways following unilateral labyrinthectomy in the frog.
Following VIIIth nerve stimulation, field potentials recorded in the contralateral vestibular nuclei of isolated medullae are larger in amplitude and more sensitive to atropine in chronically hemilabyrinthectomized frogs than those of controls. The atropine-sensitive component occurs at a latency which precludes involvement of the monosynaptic commissural projection between second order vestibular neurons. Therefore, in addition to this commissural projection, the contributions of more indirect pathways have to be considered in an attempt to understand the neuronal basis of behavioral improvement following vestibular lesions.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002799:Cholinergic Fibers / Q000502:physiology; D003472:Curare / Q000494:pharmacology; D007758:Ear, Inner / Q000601:surgery*; D005071:Evoked Potentials / Q000187:drug effects; D009434:Neural Pathways / Q000502:physiology; D011187:Posture; D011896:Rana temporaria; D014726:Vestibular Nuclei / Q000502:physiology*
D001285:Atropine; D003472:Curare