Tioconazole 2% cream in the treatment of Trichomonas vaginalis or mixed vaginal infections.
Twenty patients with documented T. vaginalis infections, six of whom were simultaneously infected with C. albicans and one with G. vaginalis, were treated topically (intravaginally) once daily with 5 g of 2% tioconazole vaginal cream (Trosyd, Pfizer) for 3 consecutive days in an open, non-comparative study. At the first follow-up visit (about 7 days post-treatment), 95% (19/20) of the patients were cured; 95% (18/19) of patients remained cured with respect to the baseline infection at the long-term follow-up (2 months post-treatment) visit, and one patient had a reinfection or relapse with T. vaginalis. Only one patient reported a side-effect, a mild vaginal burning which disappeared with continued treatment. It was concluded that tioconazole 2% vaginal cream is safe and effective for the treatment of T. vaginalis and mixed vaginal infections.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002181:Candidiasis, Vulvovaginal / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006194:Gardnerella vaginalis; D006192:Haemophilus Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D014247:Trichomonas Vaginitis / Q000150:complications / Q000188:drug therapy*; D014623:Vaginal Diseases / Q000188:drug therapy*
D007093:Imidazoles; C020527:tioconazole