Asthma, aspirin intolerance and nasal polyps.
Asthma associated with aspirin intolerance (bronchospastic type) and nasal polyps is a special type of asthma with well established characteristics. Asthma and aspirin intolerance in these patients usually occurs at the same time in life followed by nasal polyps about 10 years later. Classically, it is a non allergic steroid-dependent asthma. Desensitization to aspirin is possible but does not improve asthma. Polypectomy does not aggravate or cause asthma. The pathogenic mechanism may involve arachidonic acid metabolism.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001095:Arachidonic Acids / Q000378:metabolism; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000150:complications / Q000378:metabolism / Q000628:therapy; D004342:Drug Hypersensitivity / Q000503:physiopathology*; D006801:Humans; D009298:Nasal Polyps / Q000150:complications* / Q000601:surgery
D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids; D001241:Aspirin