[Antimetastasis effect of lymphokine-activated killer (LAK) cells on fibrosarcoma in WKA rats].
Treating WKA rats with fibrosarcoma with LAK cells, antimetastasis effect was studied. The results indicated that splenocytes incubated by IL-2 could produce lytic activity to WKA rats with fibrosarcoma in vitro. Passive infusion of LAK cells lead to a marked reduction in the number of metastatic nodules in the lung. After intravenous injection of LAK cells, cancer cells in the lung speedily disappeared. LAK cell administration for 3 times gave better result than once only (P less than 0.01). In this paper, the possibility of LAK cells used as an adoptive immunotherapy for human neoplasms is briefly discussed.
D000818:Animals; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology / Q000628:therapy*; D007116:Immunization, Passive; D007376:Interleukin-2 / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000637:transplantation*; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007376:Interleukin-2