Rheumatic manifestations of Wegener's granulomatosis.
Wegener's granulomatosis is a necrotizing granulomatous vasculitis with multisystem involvement. We reviewed the rheumatic manifestations among 50 patients with Wegener's granulomatosis. Arthralgia, myalgia and/or arthritis occurred in 2/3 of patients and 28% had nonerosive and nondeforming polyarthritis. Noninflammatory synovial fluid was found upon arthrocentesis of one patient with a knee effusion. Unexpected findings included soft tissue calcifications in 9 patients, sacroiliitis in 3, and relapsing polychondritis in 2. Rheumatoid factor was present in 1/2 of the patients tested. Additionally, both antinuclear antibodies and anti-DNA antibodies were detected in 14 and 38%, respectively, of patients tested.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000175:diagnosis; D002114:Calcinosis / Q000175:diagnosis; D002648:Child; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D011111:Polymyalgia Rheumatica / Q000175:diagnosis; D012216:Rheumatic Diseases / Q000175:diagnosis*; D013167:Spondylitis, Ankylosing / Q000175:diagnosis
D000974:Antibodies, Antinuclear