title: Classification of beta-lactamases from Branhamella catarrhalis in relation to penicillinases produced by other bacterial species.
abstract: Branhamella catarrhalis strains resistant to commonly used penicillins, and presently isolated, produce a beta-lactamase. Most of these enzymes are chromosomally mediated, but a plasmid-mediated beta-lactamase has been described (enzyme BRO-1). With reference to isoelectric points, 7 different enzymes have been identified: 6 chromosomally mediated and 1 plasmid-mediated. Nevertheless, they have many common properties, such as being biosynthesised constitutively but with a low level of production. They have a penicillinase-type profile, and are strongly inhibited by clavulanic acid.
mesh_terms: D001419:Bacteria / Q000201:enzymology*; D007525:Isoelectric Focusing; D007700:Kinetics; D008970:Molecular Weight; D009346:Neisseriaceae / Q000201:enzymology* / Q000235:genetics; D010405:Penicillinase / Q000378:metabolism*; D013045:Species Specificity; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000145:classification*
chemical_list: D065093:beta-Lactamase Inhibitors; D010405:Penicillinase; D001618:beta-Lactamases