Modification by clonidine of harmine-induced tremors in mice: involvement of serotoninergic system.
Clonidine exhibited a dose-dependent protection against harmine-induced tremors in mice. This protective effect was not completely blocked by pretreatment with yohimbine. The serotoninergic (5-HT) agonist quipazine and the uptake inhibitor fluoxetine completely antagonized this effect. On the other hand, the 5-HT antagonist cyproheptadine potentiated the protective effect of sub-effective doses of clonidine. These observations suggest a serotonin-mediated action of clonidine in its antitremor action against harmine-induced tremors.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D003533:Cyproheptadine / Q000494:pharmacology; D005473:Fluoxetine / Q000494:pharmacology; D006247:Harmine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011814:Quipazine / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology*; D014202:Tremor / Q000139:chemically induced / Q000517:prevention & control*; D015016:Yohimbine / Q000494:pharmacology
D000470:Alkaloids; D005473:Fluoxetine; D015016:Yohimbine; D003533:Cyproheptadine; D012701:Serotonin; D006247:Harmine; D011814:Quipazine; D003000:Clonidine