title: Genetic and cellular basis of anti-DNA antibody synthesis in systemic lupus erythematosus of New Zealand mice.
abstract: There is now ample evidence that multiple genes are involved in the pathogenesis of systemic lupus erythematosus (SLE) in New Zealand mice. However, it also became evident that SLE is a syndrome in which each autoimmune feature is separately controlled by a limited number of major genes although some common genes do play a role in different autoimmune features. The data obtained by genetic analyses of murine lupus are a most useful guide for studies on autoimmunity, as related to (1) the type or subset of immune cells expressing each autoimmune disease gene; (2) how each gene or the cell (in which the gene is activated) plays a role in the etiopathogenesis of the disease; and (3) how the gene actions can be manipulated. Data on aspects of the genetic and cellular basis of murine lupus, particularly as related to the anti-DNA antibody synthesis in the (NZB X NZW)F1 hybrid mice are presented based on studies done in our laboratories.
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000235:genetics*; D000936:Antigen-Antibody Complex / Q000235:genetics; D001402:B-Lymphocytes / Q000276:immunology; D004247:DNA / Q000276:immunology*; D008040:Genetic Linkage; D006023:Glycoproteins / Q000235:genetics; D006183:H-2 Antigens / Q000235:genetics; D006239:Haplotypes; D006579:Heterozygote; D007074:Immunoglobulin G / Q000235:genetics; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D008181:Lupus Nephritis / Q000235:genetics; D051379:Mice; D008814:Mice, Inbred NZB; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D006023:Glycoproteins; D006183:H-2 Antigens; D007074:Immunoglobulin G; D011948:Receptors, Antigen, T-Cell; D004247:DNA