Effect of cimetidine and pyrilamine on histamine-induced ocular surface hyperemia.
Histamine-induced ocular surface redness was virtually abolished by a combination of cimetidine (H2-receptor antagonist) and pyrilamine (H1-receptor antagonist), whereas either antagonist administered alone produced no significant reduction. It appears that combined H1- and H2-antagonist therapy is required for effective blockade of ocular responses to histamine that involve both receptor subtypes.
D000631:Aminopyridines / Q000008:administration & dosage*; D000818:Animals; D002927:Cimetidine / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005128:Eye Diseases / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D006940:Hyperemia / Q000139:chemically induced / Q000517:prevention & control*; D011738:Pyrilamine / Q000008:administration & dosage* / Q000627:therapeutic use; D011817:Rabbits
D000631:Aminopyridines; D002927:Cimetidine; D006632:Histamine; D011738:Pyrilamine