Effect of PSK on cytotoxicity against sarcoma-180 in tumor-bearing mice.
The effect of PSK, a protein-bound polysaccharide with antitumor activity, on the host defence mechanism against tumor in sarcoma-180-bearing mice was examined. PSK restored the capacity to generate cytotoxic lymphocytes and complement-requiring cytotoxic antibody in tumor-bearing mice. PSK did not, however augment cytotoxic activity in tumor-free mice.
D000276:Adjuvants, Immunologic; D000818:Animals; D000912:Antibodies, Neoplasm / Q000276:immunology; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D005260:Female; D007167:Immunotherapy; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology / Q000628:therapy; D011509:Proteoglycans / Q000627:therapeutic use*; D012513:Sarcoma, Experimental / Q000276:immunology* / Q000628:therapy; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000912:Antibodies, Neoplasm; D011509:Proteoglycans; C010770:polysaccharide-K