Chemotherapy of herpesvirus infections.
The following paper is intended to review those nucleoside analogs currently licensed for the treatment of herpetic diseases. Potentially efficacious congeners also will be considered. The mechanism of action, preclinical and clinical efficacy, and the problems associated with the use of each nucleoside analog will be described.
D000212:Acyclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D015774:Ganciclovir; D006561:Herpes Simplex / Q000188:drug therapy*; D006801:Humans; D011684:Purine Nucleosides / Q000627:therapeutic use; D011741:Pyrimidine Nucleosides / Q000627:therapeutic use
D011684:Purine Nucleosides; D011741:Pyrimidine Nucleosides; C039061:2,6-diamino-9-(2-hydroxyethoxymethyl)purine; C041468:desciclovir; D015774:Ganciclovir; D000212:Acyclovir