Pancreatic carcinogenesis in azaserine-treated rats: inhibition by a solvent mixture in the diet.
The growth of azaserine-induced foci and nodules in a 4-month experiment and the incidence of carcinomas in a 15-month experiment were greater in LEW/CrlBR inbred rats fed a purified diet (AIN-76A) than in rats fed a natural-ingredient diet (chow). Addition of a mixture of several solvents to either diet reduced the incidence of adenocarcinomas in the pancreas in the long-term study but failed to reduce the number or size of pancreatic atypical acinar cell foci in the experiments of 4 months and 6 months (chow only) duration. Apparently, some component of the solvent mixture inhibits a late stage in the development of pancreatic carcinoma. Glyceryl monooleate and propylene glycol are implicated as the components of the mixture most likely to be responsible for the inhibitory effect, but neither the identity of the critical component nor the mechanism of the inhibition is known. The solvent mixture also contained ethanol and trioctanoin.
D000818:Animals; D001377:Azaserine / Q000633:toxicity*; D004032:Diet; D000431:Ethanol / Q000494:pharmacology; D005989:Glycerides / Q000494:pharmacology; D008297:Male; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D014677:Pharmaceutical Vehicles / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew
D005989:Glycerides; D014677:Pharmaceutical Vehicles; D000431:Ethanol; D011092:Polyethylene Glycols; D001377:Azaserine; C005953:monoolein