title: The gene for familial polyposis coli maps to the long arm of chromosome 5.
abstract: The inherited genetic defect in adenomatous polyposis has been localized to a small region on the long arm of chromosome 5. Sixteen DNA marker loci were used to construct a linkage map of the chromosome. When five kindreds segregating a gene for adenomatous polyposis coli were characterized with a number of the markers, significant linkage was found between one marker and the disease gene. Linkage analysis determined the location of the defective gene within a primary genetic map of chromosome 5.
mesh_terms: D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D003111:Colonic Polyps / Q000235:genetics*; D005260:Female; D005736:Gardner Syndrome / Q000235:genetics; D005796:Genes; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics*
chemical_list: D005819:Genetic Markers