Acute psychosis in a patient receiving trimethoprim-sulfamethoxazole intravenously.
A 55-year-old man became acutely psychotic and had a pseudoseizure after receiving six doses of intravenously administered trimethoprim-sulfamethoxazole. These symptoms resolved within 24 hours after discontinuation of the medication; this finding suggests a causal effect of the drug administration.
D000208:Acute Disease; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D011605:Psychoses, Substance-Induced / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology; D012640:Seizures / Q000139:chemically induced; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000009:adverse effects*; D014295:Trimethoprim / Q000008:administration & dosage / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000890:Anti-Infective Agents; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole