Aquarium-borne Mycobacterium marinum skin infection. Report of a case and review of the literature.
A 33-year-old fish fancier developed a protracted skin infection that ultimately was found to be caused by Mycobacterium marinum. The organism was isolated from the lesion as well as from infected fish taken from his home aquarium. The lesion resolved after a six-week course of oral sulfamethoxazole and trimethoprim. Forty-four additional cases of culture-proved M marinum skin infections acquired from aquariums and reported in the English-language literature are reviewed. Almost universally, the lesions remained circumscribed and were either single nodular (14 patients) or multiple sporotrichoid (31 patients). Diagnosis was supported by acid-fast smears (15 patients) and isolation of the organism from skin lesions (43 patients) or from fish (two cases). In vitro studies, as well as clinical outcomes, suggest sulfamethoxazole-trimethoprim or ethambutol hydrochloride plus rifampin to be the drugs of choice.
D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004338:Drug Combinations / Q000627:therapeutic use; D005393:Fish Diseases / Q000635:transmission*; D005399:Fishes; D006229:Hand Dermatoses / Q000188:drug therapy / Q000635:transmission*; D006686:Hobbies; D006801:Humans; D008297:Male; D009164:Mycobacterium Infections / Q000635:transmission*; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy / Q000635:transmission*; D009170:Nontuberculous Mycobacteria / Q000302:isolation & purification; D012874:Skin Diseases, Infectious / Q000188:drug therapy / Q000635:transmission*; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole