FcR-mediated clearance in thrombopenic and non-thrombopenic patients with hemophilia A and possible relation of thrombopenia to HIV seropositivity.
As morbidity of thrombopenia in hemophilia A patients is increasing, the pathogenetic influence of the reticuloendothelial system (RES) was measured using autologous anti-Rh0(D)-coated erythrocytes (EA) in 17 patients with or without thrombopenia. Mean survival of EA in patients was reduced to 53% of healthy controls (53.2 +/- 46.1 min vs 100.5 +/- 12.2 min; patients vs controls, mean +/- S.D.). Survival of EA was not significantly different either in thrombopenic vs non-thrombopenic nor anti-HIV (human immunodeficiency virus) positive vs negative patients. Thrombopenia, elevated serum IgG and circulating immune complexes were related to the presence of anti-HIV antibodies. EA survival was also decreased in the absence of anti-HIV antibodies. This indicates activation of RES by a mechanism different from retroviral infection by HIV (1).
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000914:Antibodies, Viral / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D004906:Erythrocyte Count; D005260:Female; D006678:HIV / Q000276:immunology; D015483:HIV Antibodies; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D012157:Mononuclear Phagocyte System / Q000503:physiopathology*; D011961:Receptors, Fc / Q000502:physiology*; D013921:Thrombocytopenia / Q000209:etiology / Q000503:physiopathology*
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D015483:HIV Antibodies; D007074:Immunoglobulin G; D011961:Receptors, Fc