title: The schistosome egg granuloma: immunopathology in the cause of host protection or parasite survival?
abstract: The granulomatous inflammatory response induced by schistosome eggs entrapped in the microvasculature of host tissues is considered responsible for much of the symptomatology of schistosomiasis. However, the evolutionary role of the egg granuloma in the host-parasite relationship is not yet well defined. Some evidence indicates that the lesion may protect the host, either by shielding tissues against toxic egg products, or by interfering with the migration patterns of secondary infections, and thereby non-specifically contributing to the host's acquired "immunity". We here review earlier work concerned with the role of the egg granuloma in the host-parasite relationship in schistosomiasis, and we present new experimental evidence to suggest that the function of this cell-mediated immune response might, in addition to its putative host protective function, facilitate the extravasation of parasite eggs in the mesenteries, and thereby contribute directly to the continuation of the schistosome life-cycle.
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D006099:Granuloma / Q000276:immunology* / Q000469:parasitology; D006790:Host-Parasite Interactions; D007111:Immunity, Cellular; D008099:Liver / Q000469:parasitology; D008212:Lymphocyte Depletion; D051379:Mice; D008808:Mice, Inbred CBA; D010270:Parasite Egg Count; D012547:Schistosoma / Q000502:physiology; D012552:Schistosomiasis / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001219:Aspartate Aminotransferases