title: [Effect of cefodizime on the immune system: in vitro studies].
abstract: Cefodizime is a broad-spectrum cephalosporin with high efficacy, especially in experimental infections. The in vivo activity may be partly due to an immunomodulatory effect. Macrophages in cefodizime-treated mice showed enhanced activity (chemiluminescence, IL-1-synthesis, IFN-synthesis). The number of PFC increased during the treatment with cefodizime. The spleen cells of these mice showed elevated responses to dextransulfate and LPS but not to ConA or PHA.
mesh_terms: D000818:Animals; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology; D008163:Luminescent Measurements; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D051379:Mice
chemical_list: D007375:Interleukin-1; D002439:Cefotaxime; C033356:cefodizime
vernacular_title: Der Einfluss von Cefodizim auf das Immunsystem: In-vitro-Untersuchungen.