Comparison of growth inhibiting effect of natural and recombinant interferon-alpha on human osteosarcomas in nude mice.
Of five tested human osteosarcoma xenografts growing in nude mice, two could be growth-arrested by both natural interferon-alpha (nIFN-alpha) and recombinant IFN-alpha 2c (rIFN-alpha 2c). The other three less sensitive xenografts could only be partly growth-inhibited by the nIFN-alpha while no effect was seen with rIFN-alpha 2c. The leukocyte-derived IFN, thus, appeared to have higher antitumor activity per antiviral unit than the recombinant-produced IFN. It is questionable whether this observed difference is of practical relevance for clinical trials employing different IFN-alpha preparations.
D000818:Animals; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D012516:Osteosarcoma / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D014183:Transplantation, Heterologous
D007370:Interferon Type I; D011994:Recombinant Proteins