Direct and indirect action of flunarizine on vestibular activity.
Flunarizine administration (5 mg/Kg/os) in normal, labyrinthectomized and labyrinthectomized-cerebellectomized guinea pigs induced a depressant effect on spontaneous and evoked vestibular activities. Maximum effect was observed 90-120 min after drug administration and partial recovery at 180 min. Three different processes were involved: reduction of vestibular receptor excitability; direct inhibition of vestibular cells; inhibition of vestibular cells through strong activation of the cerebello-vestibular circuitry.
D000818:Animals; D002531:Cerebellum / Q000502:physiology; D007758:Ear, Inner / Q000502:physiology; D005071:Evoked Potentials / Q000187:drug effects; D005444:Flunarizine / Q000494:pharmacology*; D006168:Guinea Pigs; D009474:Neurons / Q000187:drug effects; D011689:Purkinje Cells / Q000187:drug effects; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D005444:Flunarizine