Cyclosporine affects the function of antigen-presenting cells.
The immunosuppressant drug cyclosporine (CsA) is known to affect T-cell function. We have studied the effect of CsA on the specific proliferative response of T-cell lines to antigen. In addition to blocking IL-2 release by specifically activated T-cell lines, CsA also affected the ability of irradiated spleen cells to present preprocessed antigen to T-cell lines. Irradiated spleen cells pulsed with antigen for 2 hr were able to stimulate a proliferative response in T-cell lines. Following a 2-hr pulse with CsA, antigen presentation by these irradiated spleen cells was reduced significantly, suggesting that CsA not only affects T cells, but also affects the function of antigen-presenting cells.
D000818:Animals; D000938:Antigen-Presenting Cells / Q000187:drug effects*; D000941:Antigens / Q000276:immunology; D002460:Cell Line; D003524:Cyclosporins / Q000494:pharmacology*; D003864:Depression, Chemical; D007376:Interleukin-2 / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008938:Mitosis / Q000187:drug effects; D013154:Spleen / Q000528:radiation effects; D013601:T-Lymphocytes / Q000187:drug effects
D000941:Antigens; D003524:Cyclosporins; D007376:Interleukin-2