Triradial configurations indicate that expression of the fragile site at Xq27 is non-lethal.
The staining pattern of BUdR-substituted sister chromatids in triradial configurations associated with the fragile site at Xq27 is reported. The pattern observed in 2nd- and 3rd-generation cells is compatible with the hypothesis that the triradial configurations are caused by mitotic non-disjunction of the distal fragment in the previous mitotic division. This in turn indicates that cells can survive expression of the fragile site in a previous cell cycle.
D001973:Bromodeoxyuridine; D005600:Fragile X Syndrome / Q000235:genetics*; D005804:Genes, Lethal; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014960:X Chromosome
D001973:Bromodeoxyuridine