"In vivo effects of rIL-2 pretreatment on chemotherapeutically induced in vivo natural cytolytic hyporesponsiveness".
Chemotherapeutics have been shown to have detrimental effects on immune response, hence, pretreatment or concurrent use of an immune augmentation substance could lead to reconstitution of an immune response such as cytolytic activity after administration of chemotherapeutic agent. Previously, in an in vitro system, we have demonstrated IL-2 pretreatment reconstituted drug induced immunosuppression as well as altered differential sensitivities to chemotherapeutic agents. This study presents evidence that in vivo functional cytolytic potential can be retained by IL-2 pretreatment on chemotherapeutically-induced natural cytolytic hyporesponsiveness.
D000818:Animals; D002460:Cell Line; D003561:Cytarabine / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011994:Recombinant Proteins / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology
D007376:Interleukin-2; D011994:Recombinant Proteins; D003561:Cytarabine; D003907:Dexamethasone; D005472:Fluorouracil