Intestinal calcium absorption in patients after jejuno-ileal bypass or small intestinal resection and the effect of vitamin D.
A forearm counter and double-isotope technique were used to measure intestinal calcium absorption in 21 patients after jejuno-ileal bypass for obesity or small intestinal resection. In all but 2 patients calcium absorption was below the normal range for 10 male controls. 3 weeks treatment with 1-alpha-hydroxyvitamin D, 1 microgram b.d., or 1,25-dihydroxyvitamin D, 1 microgram b.d., was associated with significant increases in absorption whereas 3 weeks treatment with 24,25-dihydroxyvitamin D had no effect. This study demonstrates that oral 1,25-dihydroxyvitamin D or 1-alpha-hydroxyvitamin D are effective in increasing calcium absorption.
D015650:24,25-Dihydroxyvitamin D 3; D000328:Adult; D002112:Calcifediol / Q000494:pharmacology*; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D003424:Crohn Disease / Q000601:surgery; D004100:Dihydroxycholecalciferols / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000601:surgery*; D007581:Jejunoileal Bypass; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000628:therapy; D012016:Reference Values
D004100:Dihydroxycholecalciferols; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol; D002112:Calcifediol; D002118:Calcium