title: Distribution of alpha-1-antitrypsin (Pi) phenotypes in Denmark determined by separator isoelectric focusing in agarose gel.
abstract: The distribution of phenotypes of alpha 1-antitrypsin (Pi) in 909 unrelated Danes was determined by the use of separator isoelectric focusing in agarose gel. The frequencies calculated were: PiM1 = 0.728, PiM2 = 0.136, PiM3 = 0.082, PiZ = 0.023, PiS = 0.022, PiF = 0.006, Pivar = 0.003. The segregation of phenotypes in 39 families with 94 children is presented. The advantages and disadvantages of the method are discussed.
mesh_terms: D000483:Alleles; D002648:Child; D003433:Crosses, Genetic; D003718:Denmark; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D010641:Phenotype; D011247:Pregnancy; D000515:alpha 1-Antitrypsin / Q000235:genetics*
chemical_list: D000515:alpha 1-Antitrypsin