The dopamine neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces histological lesions in the hypothalamus of the common marmoset.
The administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to marmosets resulted in parkinsonism and degeneration of the substantia nigra pars compacta. Examination of the hypothalamus showed neuronophagic-like rosettes of glial cells and diffuse increase in glial numbers in areas of the dopaminergic A11-A14 groups. These findings suggest that MPTP may be toxic to dopamine neurons of the hypothalamus as well as to the substantia nigra.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D002144:Callithrix; D005260:Female; D007027:Hypothalamic Diseases / Q000139:chemically induced* / Q000473:pathology; D007031:Hypothalamus / Q000473:pathology*; D008297:Male; D009457:Neuroglia / Q000473:pathology; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000473:pathology; D010587:Phagocytosis; D011725:Pyridines / Q000633:toxicity*
D011725:Pyridines; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine