The relation of susceptibility to and biologic behavior of thyroid epithelial cell cancer to HLA-DR1.
Fifty-two patients with thyroid epithelial cell cancer were studied for evidence of association with human leukocyte antigens (HLA). Twenty-eight patients (53.8%) and 19.4% of 160 controls were HLA-DR1-positive, conferring a relative risk of 4.85 (chi 2 = 21.3, P less than 0.0001). HLA-DR1 was increased in all histologic types of thyroid cancer. Interestingly 10 of 12 patients with metastatic disease were DR1-positive compared to 18 of 41 patients without metastases (relative risk = 6.1, chi 2 = 4.7, P less than 0.05). This study suggests that major histocompatibility complex-linked gene(s) determine susceptibility to and the biologic behavior of thyroid cancer.
D000951:Antigens, Neoplasm / Q000032:analysis*; D002277:Carcinoma / Q000276:immunology* / Q000473:pathology; D004198:Disease Susceptibility; D005260:Female; D015798:HLA-DR1 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D010641:Phenotype; D012306:Risk; D013964:Thyroid Neoplasms / Q000276:immunology* / Q000473:pathology
D000951:Antigens, Neoplasm; D015798:HLA-DR1 Antigen; D000949:Histocompatibility Antigens Class II