[Methotrexate poisoning: value of exchange transfusion].
The authors report on a case of methotrexate (MTX) intoxication occurring in a young boy treated for osteosarcoma. Exchange transfusion was shown to be an effective method. Respective indications of MTX removal methods are discussed: haemodialysis and charcoal haemoperfusion should be proposed for massive and acute intoxications; exchange-transfusion may be proposed as a treatment for prolonged and moderate intoxications.
D058186:Acute Kidney Injury / Q000139:chemically induced; D002648:Child; D005078:Exchange Transfusion, Whole Blood; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008727:Methotrexate / Q000097:blood / Q000506:poisoning*; D012516:Osteosarcoma / Q000188:drug therapy*; D013921:Thrombocytopenia / Q000139:chemically induced
D008727:Methotrexate
Intoxication au méthotrexate: intérêt de l'exsanguino-transfusion.