title: Working principles in the immune system implied by the "peptidic self" model.
abstract: The hypothesis that self as well as foreign proteins are processed into peptides and presented by major histocompatibility complex antigens leads to a set of working principles that could govern cellular interactions in immune responses. In particular, "idiopeptides," derived from immunoglobulins and T-cell receptors and recognized by appropriate T cells, are expected to play an important regulatory role. We show here that these speculations fit into a consistent view of the immune system.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D007108:Immune Tolerance; D007109:Immunity; D007130:Immunoglobulin Idiotypes; D007156:Immunologic Memory; D008285:Major Histocompatibility Complex; D008954:Models, Biological; D010455:Peptides / Q000276:immunology*; D011506:Proteins / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007130:Immunoglobulin Idiotypes; D010455:Peptides; D011506:Proteins; D011948:Receptors, Antigen, T-Cell