Exocrine pancreatic function as determined in a same-day test with use of bentiromide and p-aminosalicylic acid.
We describe a new approach to the bentiromide test of exocrine pancreatic function, p-Aminosalicylic acid (PAS), a compound closely related to the bentiromide fragment p-aminobenzoic acid (PABA), is used as a marker of the pharmacokinetic behavior of PABA to derive a PABA excretion index. This index is identical to that derived with [14C]-PABA. Concentrations of both PABA and PAS are measured in urine by "high-performance" liquid chromatography, which avoids the drug interferences encountered with established assays of PABA. We discuss the practical and diagnostic advantages of this new approach to the bentiromide test.
D010129:4-Aminobenzoic Acid / Q000378:metabolism / Q000652:urine; D000328:Adult; D062365:Aminobenzoates; D010131:Aminosalicylic Acid / Q000378:metabolism / Q000652:urine; D000636:Aminosalicylic Acids; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000502:physiology*; D010186:Pancreatic Function Tests; D062366:para-Aminobenzoates
D062365:Aminobenzoates; D000636:Aminosalicylic Acids; D062366:para-Aminobenzoates; C006717:bentiromide; D010131:Aminosalicylic Acid; D010129:4-Aminobenzoic Acid