title: Anti-SS-A antibodies and fetal outcome in maternal systemic lupus erythematosus.
abstract: In 155 women with systemic lupus erythematosus, there were no significant differences in the rates of fertility or adverse fetal outcome between the 47 (30%) with serum anti-SS-A antibody and the 108 without anti-SS-A, except in the frequency of congenital heart block. This complication occurred in 6 of 96 pregnancies in women with anti-SS-A and was associated with high-titer maternal antibody. The overall risk of a woman with lupus having an infant with congenital heart block was estimated to be 1:60, but the risk was considerably higher (1:20) if anti-SS-A antibody was present.
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000974:Antibodies, Antinuclear / Q000032:analysis*; D005260:Female; D005313:Fetal Death; D006327:Heart Block / Q000151:congenital; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D007752:Obstetric Labor, Premature / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D012189:Retrospective Studies; D012306:Risk
chemical_list: D000974:Antibodies, Antinuclear; C035356:SS-A antibodies