title: Human gene coding for granulocyte-colony stimulating factor is assigned to the q21-q22 region of chromosome 17.
abstract: Granulocyte-colony stimulating factor (G-CSF) is a member of colony stimulating factors which regulate the proliferation and differentiation of hematopoietic progenitor cells. A full-length cDNA clone coding human G-CSF was used as a hybridization probe to detect homologous sequence in human-mouse somatic cell hybrids, flow-sorted human chromosomes, and in situ human metaphase chromosomes. The results indicate that the gene encoding human G-CSF is on the q21-q22 region of chromosome 17, which is involved in translocation of t(15;17) (q23;21) in human acute promyelocytic leukemia.
mesh_terms: D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D003115:Colony-Stimulating Factors / Q000235:genetics*; D004247:DNA / Q000235:genetics; D006098:Granulocytes / Q000166:cytology*; D006801:Humans; D006822:Hybrid Cells; D007621:Karyotyping; D051379:Mice; D009693:Nucleic Acid Hybridization; D012689:Sequence Homology, Nucleic Acid
chemical_list: D003115:Colony-Stimulating Factors; D004247:DNA