New antibiotics from genetically engineered actinomycetes. I. 2-Norerythromycins, isolation and structural determinations.
Novel macrolide antibiotics have been isolated from a genetically manipulated actinomycete. The major components produced have been isolated and identified as 2-norerythromycins A, B, C and D by mass spectrometry and extensive 1D and 2D NMR experiments.
D000191:Actinomycetaceae / Q000032:analysis* / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D004917:Erythromycin / Q000031:analogs & derivatives; D005818:Genetic Engineering; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000235:genetics
D000900:Anti-Bacterial Agents; D004917:Erythromycin