title: Duplication of Ph and of 9q+ chromosomes during the blastic transformation of a CML case.
abstract: We describe the blastic transformation of a case of chronic myelocytic leukemia in which, among other abnormalities, one extra Philadelphia and one extra 9q+ were observed. Molecular studies and analysis of the clonal evolution of the karyotype led to the interpretation of such an unusual finding as the result of nondisjunction, rather than of a double t(9;22) translocation.
mesh_terms: D000328:Adult; D001752:Blast Crisis / Q000235:genetics* / Q000473:pathology; D002871:Chromosome Banding; D002899:Chromosomes, Human, Pair 9; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D008297:Male; D010677:Philadelphia Chromosome; D014314:Trisomy
chemical_list: D005819:Genetic Markers