CSF mononuclear cell subsets in active MS: lack of disease-specific alteration.
We studied CSF mononuclear cell subsets in MS and acute aseptic meningoencephalitis, using seven monoclonal antibodies. Ia-bearing cells were more frequent in active MS than in stable MS. In active MS, the percentage of Ia-bearing cells was higher than M5 cells or B7 cells, suggesting that Ia-positive T cells appear when the disease is active. However, there was no difference in the proportion of CSF cell subsets in active MS and acute aseptic meningoencephalitis; the changes in MS are similar to acute inflammatory reactions.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D005260:Female; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid / Q000276:immunology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification*
D000911:Antibodies, Monoclonal