title: Complete amino acid sequence of human transforming growth factor type beta 2.
abstract: The complete amino acid sequence of human type beta 2 transforming growth factor (hTGF-beta 2) was determined by automated Edman degradation of S-pyridylethylated hTGF-beta 2 and selected fragments. Cleavage of hTGF-beta 2 by enzymatic and chemical techniques established all the fragments in an unambiguous sequence. Human TGF-beta 2 consists of two disulfide-linked, identical subunits. Each hTGF-beta 2 subunit is a single-chain polypeptide of 112 residues, with a calculated molecular weight of 12,720. Human TGF-beta 2 displays 71.4% sequence homology with the functionally related human TGF-beta 1, and is distantly related (23-40% amino acid identity) to porcine inhibins and activins, the carboxyl-terminal regions of human Müllerian inhibiting substance, and the putative decapentaplegic gene complex protein of Drosophila.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D054304:Anti-Mullerian Hormone; D006023:Glycoproteins; D006131:Growth Inhibitors; D006801:Humans; D007265:Inhibins / Q000032:analysis; D007301:Insect Hormones / Q000032:analysis; D010449:Peptide Mapping; D010455:Peptides / Q000032:analysis*; D013552:Swine; D013735:Testicular Hormones / Q000032:analysis; D015291:Transforming Growth Factors
chemical_list: D006023:Glycoproteins; D006131:Growth Inhibitors; D007301:Insect Hormones; D010455:Peptides; D013735:Testicular Hormones; D007265:Inhibins; D015291:Transforming Growth Factors; D054304:Anti-Mullerian Hormone