Structural genes of coagulation factors VII and X located on 13q34.
From 7 cases of abnormalities involving chromosome 13, the structural gene(s) coding for coagulation factors VII and X were located in the region 13q34-13qter. Gene-dosage effects for these coagulation factors seem to act in both directions, causing a decrease when there is monosomy of segment 13q34, but also, as has not been demonstrated before, an increase when there is trisomy of this same segment.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000097:blood* / Q000235:genetics; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002901:Chromosomes, Human, 13-15; D005167:Factor VII / Q000235:genetics* / Q000378:metabolism; D005170:Factor X / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005796:Genes; D006801:Humans; D007223:Infant; D008297:Male; D014178:Translocation, Genetic; D014314:Trisomy
D005167:Factor VII; D005170:Factor X