An immunogenetic study of juvenile chronic arthritis.
Ninety-seven patients from Western Australia and Victoria suffering from juvenile chronic arthritis (JCA) for longer than 1 year were studied with particular reference to immunogenetic markers in the sub-groups of the disease. In the pauci-articular group, the antigens DR5, DR8 and BW35 were increased in frequency. The phenotypes within the sub-groups appeared distinctive despite the absence of any increase in the frequency of single antigens. Complement allotyping did not prove to be different from controls or within the sub-groups for JCA. This study supports the concept that patients with JCA have specific genetic characteristics and that sub-groups of the disease are genetically distinct.
D001171:Arthritis, Juvenile / Q000235:genetics / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003181:Complement C4 / Q000032:analysis; D015934:Complement C4a; D015935:Complement C4b; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007223:Infant; D008297:Male
D003181:Complement C4; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D015934:Complement C4a; D015935:Complement C4b