Inheritance of human-erythrocyte Gerbich blood group antigens.
The blood group-antigenic determinant Gerbich was first described greater than 25 years ago, but its mode of inheritance has not been established. We performed protein immunoblotting by means of anti-beta sialoglycoprotein (SGP) and anti-gamma SGP reagents. The anti-beta SGP was a monoclonal antibody that reacts with normal beta SGP and with the abnormal beta-related SGPs associated with Gerbich and Yus types of Ge-negative red cells. In the families studied, we have shown that the products of the Ge alleles are inherited in an autosomal codominant manner.
D000483:Alleles; D000911:Antibodies, Monoclonal; D001789:Blood Group Antigens / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D012795:Sialoglycoproteins / Q000235:genetics / Q000276:immunology
D000911:Antibodies, Monoclonal; D001789:Blood Group Antigens; D005819:Genetic Markers; D012795:Sialoglycoproteins