title: [Immunopathological manifestations of systemic lupus erythematosus and their correction during long-term dispensary observation].
abstract: The time course of immunopathological symptoms of lupus erythematosus was studied in 117 patients over a period of 5 years. It was established that routine multimodality therapy while resulting in a positive time course of clinical and clinico-biochemical indices, did not ensure the normalization of immunological parameters, particularly of the T-system of immunity. Courses of theophylline and splenin therapy were added to multimodality therapy to raise therapeutic efficacy and to return to normal the status of the immune system. A regular follow-up made it possible to stabilize the disease in 82.1% of the LE patients and to preserve working capacity in 50.4% of them.
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D003131:Combined Modality Therapy; D003165:Complement System Proteins / Q000032:analysis; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000628:therapy; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
chemical_list: D006680:HLA Antigens; D007136:Immunoglobulins; D003165:Complement System Proteins
vernacular_title: Immunopatologicheskie proiavleniia sistemnoĭ krasnoĭ volchanki i ikh korrektsiia v protsesse dlitel'nogo dispansernogo nabliudeniia.