Non-tropical idiopathic splenomegaly and chronic T cell lymphocytosis.
Non-tropical idiopathic splenomegaly (NTIS) is thought to predispose to the development of lymphoid neoplasia of B-cell type. We report a case of NTIS that evolved into a T-lymphoproliferative disorder. Review of the literature suggests that this type of evolution is not uncommon. The role of splenectomy in this progression is discussed.
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D013154:Spleen / Q000473:pathology; D013163:Splenomegaly / Q000150:complications* / Q000473:pathology; D013601:T-Lymphocytes / Q000166:cytology