title: A major gene model for the familial aggregation of plasma IgA concentration.
abstract: Plasma IgA concentration was determined on 94 individuals of an eastern Kentucky family (IGANI) with some members having clinical and biopsy-proven IgA nephropathy, and on 197 individuals of a large Louisiana family (HGAR29) with no clinical history of IgA nephropathy but on whom 30 polymorphic markers had previously been typed. Pedigree segregation analysis was used to fit a major gene model, and a moderately large lod score for linkage to the ABO locus (1.50 at 0% recombination) suggested the existence of a recessive allele for high plasma IgA concentration. This allele is only slightly more prevalent in pedigree IGANI than in pedigree HGAR29, indicating that it is a minor, rather than a major, etiologic factor in IgA nephropathy.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005808:Genes, Recessive; D008040:Genetic Linkage; D005819:Genetic Markers; D005922:Glomerulonephritis, IGA / Q000235:genetics*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000235:genetics*; D007629:Kentucky; D008145:Louisiana; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D010375:Pedigree; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers; D007070:Immunoglobulin A