Lysozyme in tears during post-operative inflammation of the eye.
Lysozyme (ly) concentration in tears was measured the day before and the days following intracapsular cataract extraction in 25 patients. A median ly concentration of 1.30 mg/ml was found pre-operatively. On the first post-operative day a significant drop in the median ly concentration was observed (0.58 mg/ml). Thereafter a gradual rise towards pre-operative level was found at the 12th post-operative day. An inverse correlation existed between ly concentrations and Schirmer values during the observation period, and dilution thus seems to be an important cause of the post-operative drop in ly concentration. We observed an inverse relationship between ly level, and the number (%) of patients displaying bacterial colonization of the conjunctival sac 24 h later. The most frequently isolated bacteria were staphylococcus albus and diphteroids. It is proposed that the drop in ly concentration post-operatively may contribute to an increased risk of bacterial colonization of the eye post-operatively.
D000328:Adult; D000368:Aged; D002387:Cataract Extraction; D009877:Endophthalmitis / Q000201:enzymology* / Q000209:etiology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000032:analysis*; D011183:Postoperative Complications / Q000378:metabolism*; D013666:Tears / Q000201:enzymology* / Q000378:metabolism
D009113:Muramidase