Cardiovascular pathology induced by passive transfer of splenic cells from syngeneic rats treated with T-2 toxin.
Mononuclear cells were separated from spleens and lymph nodes of Lewis rats treated 5 weeks previously with repeated small doses of T-2 toxin or solvent only. The cells from each site were then injected intraperitoneally into 4 groups of syngeneic Lewis rats. The animals injected with spleen cells from T-2 toxin-treated donors developed marked cardiovascular changes which were similar to those due to T-2 toxin itself. Rats injected with lymph node cells as well as those given each kind of cell from solvent-treated donors showed only occasional mild vascular changes. The changes seen after splenic cell transfer may be due to superinduction of interleukin 2 by T-2 toxin.
D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology; D007107:Immune System / Q000187:drug effects*; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008297:Male; D009000:Monocytes / Q000276:immunology / Q000637:transplantation; D009206:Myocardium / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D012717:Sesquiterpenes / Q000633:toxicity*; D013154:Spleen / Q000166:cytology* / Q000276:immunology / Q000637:transplantation; D013605:T-2 Toxin / Q000633:toxicity*
D012717:Sesquiterpenes; D013605:T-2 Toxin