Leu 7+, Leu 11a- acute T-lymphoblastic leukemia having low K cell activity and no NK cell activity.
The phenotypic and functional features of the leukemic blasts from a child with T-acute lymphoblastic leukemia (T-ALL) were studied. The leukemic cells lacked the usual markers of T-cell lineage (T3-, T11-, E-sheep-) although they displayed some T-lymphocyte markers (T6+, T8+, T9+, T10+) and were T gamma-. Furthermore, these cells had a strong reaction with anti-Leu 7 but were negative to anti-Leu 11a antibody and exhibited low K cell activity, no NK activity, and showed virtually no response to PHA. These leukemic cells probably represented the leukemic counterpart of the Leu 7+, Leu 11a- subset that has been demonstrated in the peripheral blood of normal individuals.
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D002648:Child; D006801:Humans; D007694:Killer Cells, Natural / Q000502:physiology*; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010641:Phenotype; D013601:T-Lymphocytes / Q000145:classification
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000954:Antigens, Surface