Histologic findings in siblings with acute sarcoid arthritis: association with the B8,DR3 phenotype.
Three siblings with acute sarcoid arthritis and hilar adenopathy on chest radiograph (Löfgren's syndrome) are presented. Synovianalysis from 2 of 3 showed a predominance of mononuclear cells, and synovial biopsies from 2 of the 3 showed a mild inflammatory synovitis. All 3 siblings exhibited the B8,DR3 phenotype, and HLA testing of 8 prior cases identified at this institution showed the B8,DR3 phenotype in 6 of 8 patients with the 2 other patients exhibiting either B8 or DR3 alone. We confirm an earlier report that the B8,DR3 phenotype identifies a group of patients who are more likely to have acute sarcoid arthritis and hilar adenopathy without developing chronic disease.
D000208:Acute Disease; D000328:Adult; D001168:Arthritis / Q000235:genetics* / Q000473:pathology; D005260:Female; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D010375:Pedigree; D010641:Phenotype; D012507:Sarcoidosis / Q000235:genetics* / Q000473:pathology; D013582:Synovial Fluid / Q000032:analysis; D013583:Synovial Membrane / Q000473:pathology / Q000648:ultrastructure
D006680:HLA Antigens; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II