Effects of steroidal and non-steroidal anti-inflammatory agents on corneal wound healing.
This study was designed to compare corticosteroids with ketorolac, a non steroidal anti-inflammatory drug on corneal wound healing in rabbits. The present studies indicate that 0.5% ketorolac does not significantly impair wound healing as determined by corneal tensile strength, whereas 0.1% solution of dexamethasane phosphate resulted in a significant impairment of wound healing. In addition, ketorolac does not impair healing of corneal epithelial abrasion, whereas prednisolone acetate was found to impair wound healing. The development of a non-steroidal anti-inflammatory drug such as ketorolac provides an alternative method to suppress post-surgical inflammation and does not adversely affect the cellular system involved in corneal repair.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D003315:Cornea / Q000473:pathology / Q000503:physiopathology*; D004848:Epithelium / Q000503:physiopathology; D020910:Ketorolac; D008297:Male; D011239:Prednisolone / Q000494:pharmacology*; D011758:Pyrroles / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D014046:Tolmetin / Q000031:analogs & derivatives / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011758:Pyrroles; D011239:Prednisolone; D014046:Tolmetin; D020910:Ketorolac