Antibody to HIV in patients with acute hepatitis B in the period 1975-1984.
In order to elucidate the time when HIV was introduced into a population of patients with acute hepatitis B, serum samples collected in the period 1975-1984 from 331 patients with hepatitis B were analysed for the presence of antibody to HIV (anti-HIV). Anti-HIV was not detected in any of the serum samples from 97 females. 5/234 serum samples from males (2%) were repeatedly positive. Anti-HIV was first demonstrated in 1978, 3 years before the first patients with AIDS were recognized in Denmark. None of the 4 Danish patients with anti-HIV developed AIDS during a follow-up period of 1-7 years. However, at the time of follow-up in 1985 3 had decreased cell mediated immunity. The hepatitis B infection had an uncomplicated course in 4/5 patients with anti-HIV. One patient had a protracted delta hepatitis and was a HBsAg carrier before as well as after the acute hepatitis. Thus, the HIV infection did not cause any complicated course in this study.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D000208:Acute Disease; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D003718:Denmark; D005260:Female; D005500:Follow-Up Studies; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies; D006509:Hepatitis B / Q000150:complications* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D012189:Retrospective Studies; D013997:Time Factors
D000914:Antibodies, Viral; D015483:HIV Antibodies