title: [Effect of the rate of injection of propofol on blood pressure and heart rate].
abstract: This work aimed to confirm the lack of haemodynamic effect due to the speed of injecting propofol during induction of anaesthesia. Thirty young unpremedicated ASA I patients were studied. They were randomly assigned to three groups. Induction was carried out with a single dose of 2.5 mg X kg-1 propofol, at three different speeds of injection (15, 30 and 45 s for groups 1, 2 and 3 respectively). Heart rate and systolic and diastolic blood pressures were recorded before injection and every 45 s after the end of the injection of propofol with a Doppler recorder. Statistical analysis of data was performed with Tukey's test. Systolic and diastolic arterial pressures decreased in all cases. There was an increase in heart rate which was not statistically different from control. There were no statistically significant differences between the median falls in blood pressure between groups.
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D010636:Phenols / Q000008:administration & dosage*; D015742:Propofol; D011897:Random Allocation; D013997:Time Factors
chemical_list: D000777:Anesthetics; D010636:Phenols; D015742:Propofol
vernacular_title: Influence de la vitesse d'injection du propofol sur la pression artérielle et la fréquence cardiaque.