Transient nigral ubiquinone depletion after single MPTP administration in mice.
The administration of a single injection of 30 mg/kg MPTP to mice produces at 1 hr, a transient significant decrease of the reduced ubiquinol Q10 in the substantia nigra that is normalized afterwards. This suggests a transient stress imposed by MPTP (or more likely MPP+) in the mitochondrial respiratory and/or oxidoreducing system, located in close proximity to the NADH system.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D004298:Dopamine / Q000378:metabolism; D005260:Female; D051379:Mice; D011725:Pyridines / Q000633:toxicity*; D013378:Substantia Nigra / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D014451:Ubiquinone / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology
D011725:Pyridines; D014451:Ubiquinone; D014810:Vitamin E; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine