[Natural killers and interleukin-2 in mice of the strain MRL/MpJ-lpr/lpr].
The functional activity of natural killers (NK) in the spleen and lymph nodes and interleukin-2 (IL-2) production have been studied in MPL-MpJ-lpr/lpr (H-2k) mice with genetically predetermined autoimmune diseases and CBA (H-2k) mice. In MPL/l mice it has been shown that NK activity in the spleen was markedly depressed already in the first month of life, whereas in lymph nodes there is a substantial NK activity on days 7-10, which reaches its maximum by the second month and by the 6th months is practically intractable. IL-2 production in MPL/l mice was depressed at all stages of investigation.
D000375:Aging / Q000276:immunology; D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D007376:Interleukin-2 / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology
D007376:Interleukin-2
Estestvennye killery i interleĭkin-2 u mysheĭ linii MRL/MpJ-1pr/1pr.