The effect of isometric short-term electrical stimulation on denervated muscle.
Electrical stimulation was applied daily for 20 minutes to denervated rabbit extensor digitorum longus muscle. One group was stimulated with short tetani, another with 1-Hz frequency, using isometric contractions for both. Tetanic stimulation induced severe fibrosis and is harmful to denervated muscle. One Hertz stimulation retarded denervation-induced fatigue and atrophy, as well as slowing of contraction time.
D000818:Animals; D004599:Electric Stimulation Therapy / Q000009:adverse effects; D005355:Fibrosis / Q000209:etiology; D007537:Isometric Contraction; D009119:Muscle Contraction; D009121:Muscle Denervation; D009132:Muscles / Q000473:pathology / Q000502:physiology*; D009133:Muscular Atrophy / Q000517:prevention & control; D011817:Rabbits