Distribution of alpha-1-antitrypsin and haptoglobin phenotypes in bladder cancer patients.
Frequencies of the alpha 1-antitrypsin (Pi) alleles and haptoglobin phenotypes have been determined in a series of 264 North-German patients with bladder cancer. Compared to a healthy control population, we found a statistically significant decrease of Hp 2-2 phenotype in the patient series. A significant increase of the serum Pi Z allele, as previously shown for patient groups with certain other tumours, could also be confirmed for bladder cancer. Furthermore, a distinct association between a lowered M 3 allele and bladder carcinoma was observed.
D000483:Alleles; D005787:Gene Frequency; D005819:Genetic Markers; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D010641:Phenotype; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000235:genetics*; D000515:alpha 1-Antitrypsin / Q000235:genetics*
D005819:Genetic Markers; D006242:Haptoglobins; D000515:alpha 1-Antitrypsin