Familial concurrence of pauciarticular syndrome and systemic sclerosis.
We observed a sibship of two children who had the syndrome of early-onset pauciarticular arthritis with anti-nuclear antibodies; their paternal grandmother died of progressive systemic sclerosis. Since the early-onset pauciarticular syndrome is very rare or non-existent in adults, the findings in this kindred pair raise the possibility that this disorder and adult systemic sclerosis may share some genetic or other etiological factors.
D000328:Adult; D000974:Antibodies, Antinuclear / Q000276:immunology; D001171:Arthritis, Juvenile / Q000235:genetics* / Q000276:immunology; D002675:Child, Preschool; D003165:Complement System Proteins / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000276:immunology; D007223:Infant; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012595:Scleroderma, Systemic / Q000235:genetics*
D000974:Antibodies, Antinuclear; D006680:HLA Antigens; D007126:Immunoglobulin Allotypes; D003165:Complement System Proteins