Clinical manifestations in HLA-B27-positive patients.
The clinical manifestations of rheumatic diseases have been studied in a population of 440 HLA-B27-positive patients. Fifty-eight per cent had peripheral joint involvement. After statistical analysis and clustering of characteristics, three patterns of peripheral joint involvement were found. They were referred to as the X, Y and Z type for mnemotechnical reasons. The X type includes male patients with sacroiliitis, spondylitis, uveitis and uni- or bilateral arthritis of hip and/or shoulder. Y type patients present sacroiliitis, pauci-articular asymmetrical joint involvement and tendinitis. Z type patients are characterized by sacroiliitis, polyarticular symmetrical joint involvement and a positive IgM rheumatoid factor. This classification enables a new approach to the pathology, diagnosis and therapy of the seronegative spondyloarthropathies.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001168:Arthritis / Q000150:complications* / Q000209:etiology / Q000276:immunology / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens; D015796:HLA-B27 Antigen; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology; D012217:Rheumatoid Factor / Q000032:analysis; D052256:Tendinopathy / Q000209:etiology; D014605:Uveitis / Q000209:etiology
D006680:HLA Antigens; D015796:HLA-B27 Antigen; D012217:Rheumatoid Factor