Diphenylhydantoin and phenobarbital suppress the dopaminergic neurotoxicity of MPTP in mice.
The combined administration of MPTP with the anticonvulsant drugs diphenylhydantoin or phenobarbital suppressed the MPTP-induced striatal DA depletions in mice. Co-treatment with diazepam, sodium valproate or carbamazepine was ineffective. The mechanism responsible for the protective effect of diphenylhydantoin and phenobarbital against DA neurotoxicity of MPTP is unknown but some previously available findings suggest that they may act, in part, via inhibition of MAO-B and/or DA reuptake in the striatum.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009422:Nervous System Diseases / Q000139:chemically induced / Q000517:prevention & control*; D010634:Phenobarbital / Q000494:pharmacology*; D010672:Phenytoin / Q000494:pharmacology*; D011725:Pyridines / Q000037:antagonists & inhibitors / Q000633:toxicity*; D011954:Receptors, Dopamine / Q000187:drug effects*
D000927:Anticonvulsants; D011725:Pyridines; D011954:Receptors, Dopamine; D010672:Phenytoin; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D010634:Phenobarbital