Factors influencing the bioavailability of fluoride from calcium-rich, health-food products and CaF2 in man.
After single, oral doses, 8 h profiles of fluoride (F) concentrations in plasma were determined in healthy human volunteers. Bioavailability of F from bone-meal, calcium and CaF2 tablets was evaluated in relation to that of NaF. Tablets were administered either whole or as a finely-ground powder, either to fasting subjects or with breakfast. Availability was lowest from whole tablets taken by fasting subjects, and highest from powdered substances given with breakfast. Mean F availabilities ranged between 7.2 and 39 per cent with bone-meal tablets, between 20 and 59 per cent with Ca tablets, and between 0 and 47 per cent with CaF2 tablets.
D000293:Adolescent; D001682:Biological Availability; D001688:Biological Products; D002118:Calcium / Q000378:metabolism; D002124:Calcium Fluoride / Q000378:metabolism*; D005215:Fasting; D005260:Female; D005459:Fluorides / Q000097:blood*; D006801:Humans; D008297:Male; D008903:Minerals / Q000378:metabolism; D012969:Sodium Fluoride / Q000378:metabolism
D001688:Biological Products; D008903:Minerals; D012969:Sodium Fluoride; D002124:Calcium Fluoride; D005459:Fluorides; D002118:Calcium; C027762:bone meal