Role of activated T lymphocytes in mycosis fungoides.
A patient with mycosis fungoides was treated effectively with the immunosuppressant cyclosporine A. Excretion of urinary neopterin, a marker of activation of the cellular immune system, fell immediately at the start of therapy. This result argues in support of a central role of activated T lymphocytes in this disease as has already been proposed by other authors.
D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives / Q000652:urine; D003524:Cyclosporins / Q000627:therapeutic use; D006801:Humans; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D008297:Male; D009182:Mycosis Fungoides / Q000188:drug therapy / Q000276:immunology*; D019798:Neopterin; D012878:Skin Neoplasms / Q000188:drug therapy / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D003524:Cyclosporins; D001708:Biopterins; D019798:Neopterin