title: MPTP produces a mosaic-like pattern of terminal degeneration in the caudate nucleus of dog.
abstract: This paper describes the spatial pattern of terminal degeneration in the caudate nucleus and putamen of the dog following an injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Marked inhomogeneities in the filed of terminal degeneration were found in the head of the caudate nucleus, which are reminiscent of the fundamental patch/matrix organization of the striatum. Using MPTP as a selective lesioning method, our results provide further evidence that the dopaminergic, nigrostriatal projection has a heterogeneous organization.
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000473:pathology*; D004285:Dogs; D008297:Male; D009410:Nerve Degeneration; D011699:Putamen / Q000187:drug effects / Q000473:pathology; D011725:Pyridines / Q000633:toxicity*
chemical_list: D011725:Pyridines; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine