Histiocytosis X and acute monocytic leukemia. Biologic illustration of the monocyte phagocytic system.
The concept of a mononuclear phagocytic system consisting of a continuum of cells arising from the bone marrow monoblast and terminating in the mature tissue macrophage is being actively investigated. The presentation of documented acute monocytic leukemia 18 months following the confirmed diagnosis of histiocytosis X in a 39-year-old man strongly supports the concept of the mononuclear phagocytic system lineage.
D000328:Adult; D002454:Cell Differentiation; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000473:pathology*; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000150:complications / Q000473:pathology*; D008297:Male; D009000:Monocytes / Q000166:cytology / Q000473:pathology*; D010587:Phagocytosis; D012871:Skin Diseases / Q000150:complications / Q000473:pathology*; D013997:Time Factors