Primary ciliary dyskinesia with transverse colon carcinoma.
Primary ciliary dyskinesia, characterized by chronic airway infection, impaired fertility, and situs inversus in half the number of cases, was detected in a 58-year-old Japanese woman, along with carcinoma of the transverse colon. She was of complete situs inversus and subfertile and had chronic bronchitis and nasal polyposis. Ultrastructurally, the cilia of the nasal mucosa lacked dynein arms. This is the first documentation of this disease coupled with cancer.
D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology; D000368:Aged; D002925:Ciliary Motility Disorders / Q000150:complications* / Q000473:pathology; D003110:Colonic Neoplasms / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007619:Kartagener Syndrome / Q000150:complications / Q000473:pathology; D009297:Nasal Mucosa / Q000648:ultrastructure