Complement activation after aortic endothelial injury.
Ischemic endothelial cell injury results in C activation that precedes partially via the classic pathway. This may be relevant to clinical situations of ischemia such as occur during embolization or thrombus formation. The generation of C activation products (such as C3a and C5a) may mediate many of the inflammatory changes observed in infarcted tissues.
D000818:Animals; D001011:Aorta / Q000473:pathology*; D002449:Cell Aggregation; D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis; D015926:Complement C3a; D003182:Complement C5 / Q000032:analysis; D015936:Complement C5a; D004727:Endothelium / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D011817:Rabbits
D003176:Complement C3; D003182:Complement C5; D015926:Complement C3a; D015936:Complement C5a