Suppression of antipyretic response in rabbits by intraventricular protein synthesis inhibitor, anisomycin.
Fevers induced by intravenous injection of endogenous pyrogen (EP) and intraventricular prostaglandin E2 (PGE2) were significantly prolonged when protein synthesis inhibitor, anisomycin was administrated intraventricularly 30 min before or 1 hr after injection of EP or PGE2. The present results show that protein synthesis in the central nervous system is involved in the development of antipyresis.
D000818:Animals; D000841:Anisomycin / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000037:antagonists & inhibitors*; D015232:Dinoprostone; D007276:Injections, Intraventricular; D008297:Male; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology*; D011817:Rabbits
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011458:Prostaglandins E; D011759:Pyrrolidines; D000841:Anisomycin; D015232:Dinoprostone