title: Abnormalities of copper in Gilles de la Tourette syndrome.
abstract: The Gilles de la Tourette syndrome is a disorder whose etiology and pathogenesis are little understood. The number of biochemical abnormalities described in this disorder is minimal. Ten of a total of 80 patients were found to have an abnormally low serum copper. A report is presented on two patients who consented to further detailed investigation and in whom copper radioisotope studies were carried out. Both exhibited abnormalities of copper handling, in that we observed an abnormally fast disappearance of copper from the plasma and an abnormally slow uptake by the liver. The rates of intestinal absorption and urinary excretion were normal. We did not identify an abnormal site of sequestration of the metal in the body.
mesh_terms: D000328:Adult; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000097:blood*; D006527:Hepatolenticular Degeneration / Q000097:blood; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D005879:Tourette Syndrome / Q000097:blood*
chemical_list: D003300:Copper; D002570:Ceruloplasmin