[Characteristics of the disorder in the composition of the internal medium and kidney function of vertebrate animals after cisplatin administration].
In rats, 5 days after injection of cisplatin (5 mg/kg of body weight) the urea content of the blood serum significantly increased; in pigeons, elevation of the uric acid was observed. No significant changes were found in the blood serum of the frog Rana temporaria even after injection of 40 mg/kg of cisplatin. In the black sculpin Myoxocephalus scorpius, injections of 50 mg/kg of cisplatin resulted in hypermagnesemia. Swelling of the kidney and changes in its electrolyte content were observed in rats, pigeons, and frogs, the wet weight of the kidney increased in rats and pigeons. In all the animals, accumulation of platinum in the kidney was observed, its content being dependent on the injected dose. The data obtained reveal lower sensitivity of the kidney in cold blood vertebrates to toxic effect of cisplatin and demonstrate that the pattern of disturbances in composition of the blood serum is related to the extent of the excretory function of the kidney within the species.
D000818:Animals; D001769:Blood / Q000187:drug effects*; D002945:Cisplatin / Q000633:toxicity*; D010856:Columbidae; D004305:Dose-Response Relationship, Drug; D005399:Fishes; D007668:Kidney / Q000032:analysis / Q000187:drug effects* / Q000502:physiology; D009929:Organ Size / Q000187:drug effects; D011188:Potassium / Q000032:analysis; D011896:Rana temporaria; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000032:analysis; D014508:Urea / Q000097:blood
D014508:Urea; D012964:Sodium; D002945:Cisplatin; D011188:Potassium
Osobennosti narusheniia sostava vnutrenneĭ sredy i funktsii pochki u nekotorykh pozvonochnykh zhivotnykh posle vvedeniia tsis-platiny.