A subpopulation of t(2;14)(p11;q32) cells in ataxia telangiectasia B lymphocytes.
Partially purified B cells from ataxia telangiectasia (A-T) patients and normal individuals were stimulated with Staphylococcus aureus Cowan I organisms (SAC). High levels of apparently random rearrangements were seen in the A-T B cells only. In addition a t(2;14)(p11;q32) rearrangement was identified in B cells from more than one patient.
D001260:Ataxia Telangiectasia / Q000235:genetics*; D001402:B-Lymphocytes / Q000145:classification / Q000648:ultrastructure*; D002478:Cells, Cultured; D002871:Chromosome Banding; D002900:Chromosomes, Human, 1-3; D002901:Chromosomes, Human, 13-15; D006801:Humans; D007621:Karyotyping; D014178:Translocation, Genetic