Megaloblastic bone marrow changes after repeated nitrous oxide anaesthesia. Reversal with folinic acid.
A seriously ill patient was found to have megaloblastic changes in his bone marrow after a nitrous oxide anaesthesia which lasted for 105 min. After an interval of 7 h a second nitrous oxide anaesthetic was administered, during which the patient received 30 mg of folinic acid. His marrow was normal when assessed 4 h later.
D000293:Adolescent; D000769:Anesthesia, Inhalation / Q000009:adverse effects*; D001853:Bone Marrow / Q000187:drug effects*; D004913:Erythrocytes, Abnormal / Q000187:drug effects*; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D008297:Male; D008534:Megaloblasts / Q000187:drug effects*; D009609:Nitrous Oxide / Q000009:adverse effects*
D009609:Nitrous Oxide; D002955:Leucovorin