title: [Experiences with intravenous sulprostone administration in massive postpartal hemorrhage].
abstract: Forty-three patients at the University Gynecology Clinic in Charlottenburg were given the prostaglandin E2 derivative sulprostone for severe postpartal hemorrhage. It was administered intravenously in a dose of 1.7 mcg/min (100 mcg/100 ml/h), with short-term increases to three times this amount in isolated cases. The drug proved highly efficacious (rapid onset and lasting effect). In 80% of the cases there were no side effects. Rises in body temperature occurred in six patients and in one patient a venous irritation developed in the arm into which the drug was infused. An RDS occurred, though it was considered that there was not necessarily a causal connection between this and the sulprostone infusion. In the authors' experience this drug has an established place in the treatment of atonic postpartal hemorrhage emergencies.
mesh_terms: D000328:Adult; D015232:Dinoprostone / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D006473:Postpartum Hemorrhage / Q000188:drug therapy*; D011247:Pregnancy; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage* / Q000009:adverse effects; D014590:Uterine Contraction / Q000187:drug effects; D014593:Uterine Inertia / Q000188:drug therapy
chemical_list: D011459:Prostaglandins E, Synthetic; C016767:sulprostone; D015232:Dinoprostone
vernacular_title: Erfahrungen mit intravenöser Sulproston-Applikation bei massiven postpartalen Blutungen.