title: Development of an intra-oral single-section remineralization model.
abstract: An intra-oral model system has been developed which uses a single-section technique for before-and-after measurements on the same tissue. This model allows for placement of sections of enamel at both buccal and approximal sites. These sections may be sound or possess white-spot lesions. This allows for the evaluation of lesion initiation, lesion progression, and/or lesion remineralization. The sections are appropriate for measurement by polarized light microscopy, and, although not included in this study, they are also suitable for microradiographic evaluation. With ten human volunteers, the model system was evaluated by means of three rinse regimens in a cross-over design. The distilled water rinse showed the whole range of possible changes (e.g., demineralization, no change, and remineralization). More consistent remineralization was observed when a fluoride rinse or a remineralizing fluid was used. This model system should prove to be quite useful in evaluation of demineralization and remineralization phenomena in the oral environment.
mesh_terms: D000328:Adult; D002130:Calcium Phosphates / Q000494:pharmacology; D003442:Crowns; D003731:Dental Caries / Q000473:pathology / Q000503:physiopathology; D003743:Dental Enamel / Q000187:drug effects / Q000473:pathology; D003750:Dental Fissures / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D012969:Sodium Fluoride / Q000494:pharmacology; D014089:Tooth Remineralization
chemical_list: D002130:Calcium Phosphates; D012969:Sodium Fluoride