Mode of action of a B cell potentiation factor spontaneously produced by T cells in MRL/MP-lpr/lpr mice.
Splenic T cells of young MRL/l mice, one of the murine lupus strains, were found to produce a factor which potentiates antibody production [T. Ashiba, A. Hishinuma, Y. Imai, T. Osawa: Int. Archs Allergy appl. Immunol. 83, 321-324 (1987)]. In this paper, evidences are presented for the fact that the factor augments antibody production not by enhancement of helper activity of T cells or effectiveness of antigen-presenting cells, but by direct action on B cells.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D066298:In Vitro Techniques; D015847:Interleukin-4; D007378:Interleukins / Q000096:biosynthesis*; D007526:Isoelectric Point; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*
D007378:Interleukins; D015847:Interleukin-4