[Intracameral penetration of pefloxacine in man].
Authors have studied the intraocular penetration of a new antibiotic, pefloxacin in 35 patients (35 eyes). This study emphasizes the three main qualities of this recent quinolone in ophthalmology: wide spectrum adequate for the most pathogens commonly found in endophthalmitis. Very large penetration in the aqueous humour flow with an average level of 0.95 mu/ml, which is over the minimal inhibitory concentration for many bacterial infections and is equal to 25% of average serum level.
D000368:Aged; D000867:Anterior Chamber / Q000378:metabolism*; D000890:Anti-Infective Agents / Q000378:metabolism / Q000627:therapeutic use*; D009877:Endophthalmitis / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D015366:Pefloxacin
D000890:Anti-Infective Agents; D015366:Pefloxacin; D009643:Norfloxacin
La pénétration intracamérulaire de la péfloxacine chez l'homme.