title: Ultrastructure of swine myelogenous leukaemic cells, with particular reference to intracytoplasmic granules.
abstract: Seven cases of swine myeloid leukaemias were investigated by light and electron microscopy. All animals were adult sows. Morphologically these cases were classified as myeloblastic leukaemia with maturation (Cases 1 to 6) and chronic myeloid leukaemia (Case 7). The neoplastic cells were composed of immature promyelocytoid cells in Case 1. In Cases 2, 3, 4 and 5 there were immature or mature promyelocytoid cells containing peroxidase-positive granules. In Case 6, the neoplastic cells consisted of promyelocytoid cells and myelocytoid cells. The latter predominated and contained not only peroxidase-positive granules but also peroxidase-negative ones. The neoplastic cells in Case 7 showed various stages of cell maturation. The morphological characteristics in our cases resembled those in human myeloid leukaemias.
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D003594:Cytoplasmic Granules / Q000473:pathology*; D005260:Female; D006098:Granulocytes / Q000648:ultrastructure; D006651:Histocytochemistry; D007951:Leukemia, Myeloid / Q000473:pathology / Q000662:veterinary*; D008854:Microscopy, Electron; D013552:Swine; D013553:Swine Diseases / Q000473:pathology*