title: The phenotypic frequencies of group specific component and alpha-2-HS-glycoprotein in three ethnic groups. The use of these proteins as racial markers in forensic biology.
abstract: The phenotypic frequencies of group-specific component (Gc) and alpha-2-HS-glycoprotein (A2HS) were determined in White European, Asian and Afro-Caribbean populations. Typical allele frequencies were observed for Gc, with Gc 1S being the major allele for the first two groups and Gc 1F being the major allele for Afro-Caribbeans. For all groups the dominant A2HS allele was A2HS 1, although Asians had a significantly higher proportion of this allele than the White Europeans. Gc and A2HS either singly or in combination with other blood grouping systems provide good discriminating potential. The A2HS 10 allele was detected with a very low frequency in the White European group (A2HS 10 = 0.0013) and was not detected in the Asian group, while the Afro-Caribbean group had a relatively high frequency of this allele (A2HS 10 = 0.0966). The different distribution of the Gc 1F and A2HS 10 alleles in White Europeans and Asians compared with Afro-Caribbeans, can be used to determine the likelihood of blood coming from an Afro-Caribbean.
mesh_terms: D000354:Africa, Western / Q000208:ethnology; D000483:Alleles; D001208:Asia / Q000208:ethnology; D001798:Blood Proteins / Q000235:genetics*; D004739:England; D005060:Europe / Q000208:ethnology; D005554:Forensic Medicine; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D008722:Methods; D010641:Phenotype; D044469:Racial Groups; D014809:Vitamin D-Binding Protein / Q000235:genetics*; D060749:alpha-2-HS-Glycoprotein
chemical_list: C556354:AHSG protein, human; D001798:Blood Proteins; D005819:Genetic Markers; D014809:Vitamin D-Binding Protein; D060749:alpha-2-HS-Glycoprotein