Pi MZ phenotype and an increased prevalence of reported psoriasis in a community survey.
In a community survey of 953 adults we identified 40 who reported having had psoriasis. Eight of these cases were subsequently documented from physicians' records. alpha 1-Antitrypsin (alpha 1-AT) phenotyping identified 35 MZ individuals, 4 (11.4%) of whom reported psoriasis. Among the 918 non-MZ individuals 36 (3.9%) reported psoriasis, yielding a relative incidence of 3.2 (p less than 0.05). This is consistent with previous reports suggesting an association between moderate alpha 1-AT deficiency and psoriasis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D004812:Epidemiologic Methods; D005787:Gene Frequency; D006801:Humans; D008875:Middle Aged; D010641:Phenotype; D011565:Psoriasis / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D012525:Saskatchewan; D000515:alpha 1-Antitrypsin / Q000235:genetics*; D019896:alpha 1-Antitrypsin Deficiency
D000515:alpha 1-Antitrypsin