[HLA B27-negative forms of Bechterew's disease].
For an 8 year period 45 patients with Bechterew's disease were found who had no antigen HLA-B27. 35 of the patients were tested for HLA--A, -B or -C. In 12 patients antigens of the cross-reacting group B27 (B7, Bw22 and B40) were found. In patients without psoriasis antigens B13, B16, B17 which are known to be related to psoriasis vulgaris were found. 9 patients were antigen Cw2 carriers which is in unbalanced linkage with B27. The B27 negative forms present several clinical features: late onset of the disease, slow and favourable course, development of spinal forms only, lack of iridocyclitis and heart lesions.
D000328:Adult; D003429:Cross Reactions; D004198:Disease Susceptibility; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011565:Psoriasis / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000276:immunology*
D006680:HLA Antigens; D015796:HLA-B27 Antigen
HLA B27 negativni formi na bolestta na Bekhterev.