Diagnostic and prognostic significance of t(1;3)(p36;q21) in the disorders of hematopoiesis.
We describe a cytogenetic abnormality with important diagnostic and prognostic implications. The translocation t(1;3)(p36;q21) is an acquired chromosomal rearrangement associated with myelodysplastic syndromes, which have a high propensity for conversion to refractory acute nonlymphocytic leukemia.
D000293:Adolescent; D000328:Adult; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002893:Chromosomes, Human, Pair 3; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics*; D011289:Preleukemia / Q000235:genetics; D011379:Prognosis; D014178:Translocation, Genetic
D005819:Genetic Markers