Reduced acetylation of procainamide by para-aminobenzoic acid.
Acetylation is the major route of metabolism of many drugs including the antiarrhythmic agent procainamide. Coadministration of para-aminobenzoic acid was observed to decrease the biotransformation of procainamide to N-acetylprocainamide in a patient with rapid acetylation kinetics. In view of the distinct antiarrhythmic and toxic properties of procainamide and N-acetylprocainamide, the observed drug interference may have great clinical relevance in long-term oral antiarrhythmic therapy and in instances where other drugs converge for acetylation.
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D000107:Acetylation; D062365:Aminobenzoates / Q000494:pharmacology*; D004347:Drug Interactions; D004594:Electrophysiology; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission; D011342:Procainamide / Q000378:metabolism*; D013610:Tachycardia / Q000378:metabolism* / Q000503:physiopathology
D062365:Aminobenzoates; D011342:Procainamide; D010129:4-Aminobenzoic Acid