Evaluation of the anxiolytic and amnestic effects of diazepam and midazolam for minor oral surgery.
Thirty three healthy patients (ASA 1) who required the removal of impacted third molars were included in a double-blind cross-over trial to compare the amnestic and anxiolytic efficacy of diazepam and midazolam. The anxiolytic properties of the two drugs were assessed objectively by the measurement of changes in blood pressure, pulse rate, plasma cortisol levels, and subjectively by a patient assessment using a visual analogue scale for anxiety. The amnestic properties were evaluated by patient's ability to recall two visual stimuli they were shown. The first drug given was titrated to clinical sedation and the second drug was given in an "equipotent" ratio of 1.0 midazolam to 2.86 diazepam. There was a statistically significant fall in anxiety and good levels of amnesia achieved using both drugs. No statistical differences were detected between the two drugs.
D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000517:prevention & control*; D003975:Diazepam / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D008874:Midazolam / Q000494:pharmacology*; D008875:Middle Aged; D008964:Molar, Third / Q000601:surgery; D014095:Tooth, Impacted / Q000601:surgery
D003975:Diazepam; D008874:Midazolam