[Enhanced stability of isolated muscles and actomyosin due to the action of anesthetics in subnarcotic concentrations].
Subnarcotic concentrations of anesthetics and model anesthetics prolong the survival time of isolated living frog skeletal muscles, the time of contractile ability of the same glycerinated muscles, and the time of frog skeleton muscle actomyosin denaturation. The mode of anesthetic action involves hydrophobic interactions of anesthetics with the investigated biosystems. According to the quantitative analysis, physico-chemical parameters of the anesthetic-binding sites are identical in muscle and in muscle models. This result is interpreted as an evidence that anesthetic-evoked rising of contractile protein stability may be involved in the mechanism of stabilization of isolated muscles.
D000205:Actomyosin / Q000378:metabolism*; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects*; D011489:Protein Denaturation / Q000187:drug effects; D011896:Rana temporaria; D014022:Tissue Survival / Q000187:drug effects
D000777:Anesthetics; D000205:Actomyosin
Uvelichenie ustoĭchivosti izolirovannykh myshts i aktomiozina, vyzvannoe deĭstviem anestetikov v subnarkoticheskikh kontsentratsiiakh.