Distribution of nicotinic binding sites with respect to CRF and neurophysin immunoreactive perikarya within the rat hypothalamus.
These studies determined the differential autoradiographic distribution of [125I]alpha-bungarotoxin versus [3H]nicotine relative to the histochemically defined perikarya for neurophysin and corticotropin releasing factor (CRF). Specific [3H]nicotine binding sites occurred in relatively greater density within the neuropil surrounding PVN and SON compared to within the nuclei. In contrast, the highest density of [125I]alpha-BTX sites codistributed with neurophysin immunoreactive perikarya within these nuclei.
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000032:analysis* / Q000276:immunology; D007031:Hypothalamus / Q000166:cytology / Q000502:physiology*; D008297:Male; D009481:Neurophysins / Q000032:analysis* / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D011978:Receptors, Nicotinic / Q000378:metabolism*
D009481:Neurophysins; D011978:Receptors, Nicotinic; D003346:Corticotropin-Releasing Hormone