Biochemical consequences of 2'-deoxycoformycin treatment in a patient with T-cell lymphoma. Some unusual findings.
The nucleotide content of the various blood cells and the urinary excretion of purine and pyrimidine metabolites were studied in a patient with a T-cell lymphoma (early T-cell phenotype) before and during treatment with deoxycoformycin (dCF; given intravenously [iv] during 3 days, biweekly). During and after the administration of dCF, high amounts of dATP were found in the lymphoid cells and the erythrocytes (maximally, 480 pmol/10(6) lymphocytes and 5.5 nmol/10(6) erythrocytes), but not in the polymorphonuclear leukocytes. The amount of dATP in the erythrocytes, however, was significantly lower than described in the literature. During each administration of dCF, the number of blast cells in the peripheral blood rose initially, followed by a rapid decrease. After three courses, a hematologic remission was achieved and maintained for 6 weeks; then an autologous bone-marrow transplantation was performed. During the first dCF course a large amount of deoxyadenosine was found in the urine. During the second course, this excretion was much lower, but still higher than in healthy individuals. In the patient described, dCF showed a highly specific toxicity for the immature T-lymphoblast; hardly any changes were seen in the numbers of the other hematopoietic cells, both in the blood and in the bone marrow.
D002648:Child; D002851:Chromatography, High Pressure Liquid; D003070:Coformycin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D003838:Deoxyadenine Nucleotides / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D015649:Pentostatin; D011687:Purines / Q000652:urine; D011743:Pyrimidines / Q000652:urine; D012263:Ribonucleosides / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism
D003838:Deoxyadenine Nucleotides; D011687:Purines; D011743:Pyrimidines; D012263:Ribonucleosides; D003070:Coformycin; D015649:Pentostatin