An IgM-producing immunocytoma induces large numbers of splenic T lymphocytes with Fc mu receptors.
The expression of Fc mu receptors was investigated using spleen cells from (LOU/M/Wsl X CFY) F1 rats bearing the IR202 tumour, an IgM-producing immunocytoma. It was found that the progressively growing solid tumour was accompanied by an extraordinary expansion of host splenocytes with Fc mu receptors. These cells were nylon-wool non-adherent, Thy-1-positive and sIg-negative: features they have in common with T lymphocytes. In addition, the expansion of Fc mu receptor-bearing T cells in IR202 immunocytoma is correlated to the high level of serum IgM. These observations provide further insight into the mechanism of isotype-specific T-lymphocyte Fc receptor expression, and identify a potential model with which to analyse the immunoregulatory role of Fc mu receptor-bearing T cells.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000096:biosynthesis*; D007108:Immune Tolerance; D007075:Immunoglobulin M / Q000096:biosynthesis*; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000473:pathology; D009360:Neoplastic Cells, Circulating; D051381:Rats; D011919:Rats, Inbred Strains; D011961:Receptors, Fc / Q000032:analysis*; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000912:Antibodies, Neoplasm; D007075:Immunoglobulin M; D011961:Receptors, Fc; C035311:immunoglobulin M receptor