Cellular glutathione content and K values.
The K values for two cell strains with differing intrinsic GSH concentrations have been measured with the yield of DNA breaks as end-point of the radiation effect. The K value of the strain with reduced GSH content was decreased (1.59 microM O2) in comparison to the K value (3.01 microM O2) for the strain with a normal GSH content. The significance of the observation is discussed in relation to competition models. All variants of the competition model agree in predicting a reduction of K, if GSH is reduced.
D002477:Cells / Q000528:radiation effects*; D005978:Glutathione / Q000502:physiology*; D010100:Oxygen / Q000502:physiology*; D011836:Radiation Tolerance
D005978:Glutathione; D010100:Oxygen