title: [Interaction between cotrimoxazole and antidepressive agents].
abstract: The association cotrimoxazole-tricyclic antidepressants seems to involve a rapid relapse of the depressive states continuously treated with the latter drugs. Five cases are reported. Mechanisms of this unknown drug interaction are discussed. The hypothesis of an enzymatic induction is not the most probable. A central inhibition of the tricyclic antidepressants seems to be possible but needs to be supported by further evidence.
mesh_terms: D000890:Anti-Infective Agents / Q000378:metabolism*; D000928:Antidepressive Agents / Q000378:metabolism*; D003866:Depressive Disorder / Q000188:drug therapy / Q000378:metabolism; D004338:Drug Combinations / Q000378:metabolism; D004347:Drug Interactions; D004790:Enzyme Induction; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013420:Sulfamethoxazole / Q000378:metabolism*; D014295:Trimethoprim / Q000378:metabolism*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
chemical_list: D000890:Anti-Infective Agents; D000928:Antidepressive Agents; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole
vernacular_title: Interaction entre le cotrimoxazole et les antidépresseurs.