HLA and multiple sclerosis in south east Wales.
A stronger association has been found between multiple sclerosis and HLA-DR2 than -DQwl in south east Wales (prevalence c 113/10(5)) in contrast to recent observations in north east Scotland (prevalence 178/10(5). The complex relationship between the HLA system and multiple sclerosis, demonstrated in this and other studies, is explained more easily under a polygenic model of inheritance, in which environmental events and genes interact, than by the presence of a single susceptibility gene.
D005787:Gene Frequency; D005819:Genetic Markers; D006680:HLA Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D015802:HLA-DR2 Antigen; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D012307:Risk Factors; D014852:Wales
D005819:Genetic Markers; D006680:HLA Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D015802:HLA-DR2 Antigen