title: HLA and antigluten antibodies in children with celiac disease.
abstract: IgG and IgA antigluten antibodies (Gab) were assayed in 83 celiac disease (CD) patients typed for HLA and Gm markers. Their titer and frequency were lower when a gluten-free diet was given than in active CD; these were significantly correlated, whereas no correlation was found between titer and serum Ig. Persistence of high titers was mainly confined to HLA-DR3 negative females (45% vs 6.7% of DR3 positive females and 19.3% of males). No association was found with any Gm allotype, in contrast with the previously reported involvement of the "fnb" haplotype with both CD susceptibility and Gab persistence in patients on a gluten-free diet. A technical and/or genetic explanation could be given for these differences.
mesh_terms: D002446:Celiac Disease / Q000276:immunology*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005983:Glutens / Q000276:immunology*; D006681:HLA-D Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D015803:HLA-DR3 Antigen; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007129:Immunoglobulin Gm Allotypes / Q000032:analysis*; D008297:Male; D012737:Sex Factors
chemical_list: D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D007070:Immunoglobulin A; D007129:Immunoglobulin Gm Allotypes; D005983:Glutens