title: Pharmacological evaluation of an intra-oral fluoride-releasing device in adolescents.
abstract: The purpose of this study was to quantify fluoride (F) concentrations in body fluids of adolescents wearing two intra-oral fluoride-releasing devices (IFRDs) designed to release 0.10 mg F/day. Fluoride concentrations were determined potentiometrically. No significant increases occurred in urine or serum F concentrations during the 26-week device phase. Elevated salivary F concentrations were maintained throughout the device phase when broken or depleted IFRDs were replaced. However, salivary F concentrations returned to pre-device phase values by 26 weeks when the original IFRDs were maintained. These findings suggest that IFRDs can significantly elevate salivary F concentrations of adolescents without significant elevations in systemic F concentrations.
mesh_terms: D000293:Adolescent; D002648:Child; D003692:Delayed-Action Preparations; D004867:Equipment Design; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood / Q000652:urine; D006801:Humans; D008297:Male; D012463:Saliva / Q000032:analysis*
chemical_list: D003692:Delayed-Action Preparations; D005459:Fluorides