Penetration of amoxycillin and clavulanic acid into bone.
The levels of amoxycillin and clavulanic acid have been measured in bone, serum and synovial fluid following the administration of 1.2 g Augmentin prior to hip replacement. Both antibiotics readily enter synovial fluid in levels similar to that found in serum. The levels found in bone are a minimum of ten times lower than those found in serum. Sequential administration of Augmentin with a six-hourly dose schedule does not increase the levels found in any of the tissues studied.
D000368:Aged; D000658:Amoxicillin / Q000097:blood / Q000378:metabolism*; D019980:Amoxicillin-Potassium Clavulanate Combination; D001842:Bone and Bones / Q000378:metabolism*; D002969:Clavulanic Acids / Q000097:blood / Q000378:metabolism*; D004338:Drug Combinations / Q000097:blood / Q000378:metabolism; D005260:Female; D005270:Femur Head / Q000378:metabolism; D006622:Hip Prosthesis; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D013582:Synovial Fluid / Q000378:metabolism; D065093:beta-Lactamase Inhibitors
D002969:Clavulanic Acids; D004338:Drug Combinations; D065093:beta-Lactamase Inhibitors; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin