Is GABA an afferent transmitter in the vestibular system?
This study was undertaken to determine the possible role of GABA as an afferent transmitter in the vestibular system of the axolotl. We studied the effects of GABA, muscimol, bicuculline and picrotoxin on the spontaneous spike discharge of the afferent fibers of the sacculi lagena and anterior semicircular canal. It was found that GABA and muscimol produce a very weak excitatory effect which does not mimic either the temporal course or the amplitude of the response of vestibular afferents to physiological stimuli. The GABA antagonist bicuculline has no significant effect on these fibers, and picrotoxin partially blocks the spontaneous activity in 33% of the fibers studied. These results indicate that GABA is probably not an afferent transmitter in the vestibular system as has previously been proposed.
D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology*; D000558:Ambystoma mexicanum; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D004558:Electric Stimulation; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D018756:GABA Antagonists; D009118:Muscimol / Q000494:pharmacology; D009412:Nerve Fibers / Q000187:drug effects; D010852:Picrotoxin / Q000494:pharmacology; D014722:Vestibule, Labyrinth / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology / Q000502:physiology*
D001640:Bicuculline; D018756:GABA Antagonists; D009118:Muscimol; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid