title: Isolated Raynaud's phenomenon--a benign disorder.
abstract: Ninety-seven patients presenting with isolated Raynaud's phenomenon were evaluated clinically and immunologically. Three patients developed progressive systemic sclerosis in a 3-5-year follow-up. Nineteen patients had positive antinuclear antibody, 32 depressed serum complement, and 31 elevated serum immune complexes. None of the immunologic abnormalities had obvious diagnostic significance.
mesh_terms: D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D002648:Child; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011928:Raynaud Disease / Q000235:genetics* / Q000276:immunology; D012595:Scleroderma, Systemic / Q000209:etiology*; D013997:Time Factors
chemical_list: D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D003165:Complement System Proteins