T-cell receptor gene rearrangement in regressing atypical histiocytosis.
A case of regressing atypical histiocytosis having characteristic clinical and light microscopic findings was studied immunologically for immunoglobulin and T-cell receptor gene rearrangement and for DNA ploidy analysis. Immunologic phenotyping and rearrangement of T-cell receptor Beta- and gamma-chain genes indicated that this primary cutaneous neoplasm, previously considered "histiocytic" in origin, is most probably of T-cell lineage.
D002874:Chromosome Mapping; D005260:Female; D006801:Humans; D008206:Lymphatic Diseases / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D009365:Neoplasm Regression, Spontaneous; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000145:classification*
D011948:Receptors, Antigen, T-Cell