Factor XII deficiency and von Willebrand's disease in a family of miniature poodle dogs.
The simultaneous occurrence of factor XII deficiency and von Willebrand's disease (VWD) is described in a family of Miniature Poodles affected concurrently with a familial non-spherocytic hemolytic anemia. Although there was a dominant distribution of factor XII deficiency in this family of dogs, only the dogs suffering from non-spherocytic hemolytic anemia had concurrent VWD gene expression. Neither the factor XII deficient dogs nor the VWD carrier dogs displayed bleeding tendencies.
D000818:Animals; D001779:Blood Coagulation Factors / Q000032:analysis; D004283:Dog Diseases / Q000175:diagnosis* / Q000235:genetics; D004285:Dogs; D005175:Factor XII Deficiency / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*; D005260:Female; D008297:Male; D014842:von Willebrand Diseases / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*
D001779:Blood Coagulation Factors