title: Linkage of the steroid sulfatase gene to the sex-reversed mutation in the mouse.
abstract: Dosage studies and the inheritance pattern of the gene for steroid sulfatase (Sts) in the mouse have previously provided indirect evidence for a functional Y-linked allele which recombines obligatorily with its X-linked allele in male meiosis. In this study, we have investigated the linkage relationship of Sts and the sex-reversed mutation (Sxr), a gene which is known to reside in the pairing region of the Y chromosome. The results clearly demonstrate that Sxr and Sts are linked in a region of obligatory recombination and Sts maps proximal to Sxr with most recombinants occurring proximal to the two genes.
mesh_terms: D000483:Alleles; D000818:Animals; D008040:Genetic Linkage; D051379:Mice; D011995:Recombination, Genetic; D012730:Sex Chromosomes; D012732:Sex Determination Analysis; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000235:genetics*
chemical_list: D013429:Sulfatases; D043266:Steryl-Sulfatase