[C3 stimulates the proliferation of human pre-B Raji cells].
In a defined medium in which transferrin (3 micrograms/ml) was the only source of exogenous proteins, Raji cells of the human pre-B lymphoblastoid cell line died within 48 h after forming polykaryons. The simple addition of purified C3 at a concentration equal to or higher than 3 micrograms/ml allowed Raji cells to divide. This preliminary report provides a defined system for studying the mitogenic effect of human C3 or C3 fragments upon proliferation of human B-cells lines.
D001402:B-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D003176:Complement C3 / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008934:Mitogens; D010446:Peptide Fragments / Q000276:immunology
D003176:Complement C3; D008934:Mitogens; D010446:Peptide Fragments
Le C3 stimule la prolifération des cellules humaines pré-B de la lignée Raji.