Evidence for the involvement of a capsaicin-sensitive innervation in the afferent branch of micturition reflex in rats.
Functional evidence is presented indicating the presence in the rat urinary bladder of a capsaicin-sensitive innervation which is involved in regulating micturition threshold. Endogenous substance P and/or related tachykinins appear to be present in the capsaicin-sensitive nerve endings of the rat bladder and may play a neurotransmitter role in relaying information concerned with bladder volume from the detrusor muscle to the central nervous system. In addition, neurotransmitter release from the peripheral ending of the capsaicin-sensitive fibers may play an efferent role in certain motor and/vascular responses at bladder muscle level.
D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D004351:Drug Resistance; D009479:Neuropeptides / Q000502:physiology; D051381:Rats; D012018:Reflex / Q000187:drug effects* / Q000502:physiology; D015320:Tachykinins; D013779:Tetrodotoxin / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D014554:Urination / Q000187:drug effects*
D009479:Neuropeptides; D015320:Tachykinins; D013779:Tetrodotoxin; D002211:Capsaicin