[Action of the antitumor antibiotic aclarubicin on the blood system and bone marrow hematopoiesis in an experiment].
The effect of various doses of antitumor antibiotic aclarubicin on the peripheral blood system and medullary hemopoiesis was studied on Wistar rats. It was shown that intraperitoneal administration of the drug in doses of 0.08, 0.33 and 1.2 mg/kg daily for 6 months did not induce any significant changes in the blood count of the animals. The dose of 1.2 mg/kg which is almost 2.5 times higher than the maximum course dose of aclarubicin for patients induced a decrease in the hemoglobin count recorded within the whole observation period. A single administration of aclarubicin in LD50 equal to 17.4 mg/kg resulted in marked suppression of hemopoiesis. The drug had the most prolonged suppressive effect on the bone marrow myeloid body. Depression of erythropoiesis was short-term.
D015250:Aclarubicin; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D001769:Blood / Q000187:drug effects*; D001772:Blood Cell Count / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006410:Hematopoiesis / Q000187:drug effects*; D007928:Lethal Dose 50; D009279:Naphthacenes / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; D015250:Aclarubicin
Deĭstvie protivoopukholevogo antibiotika aklarubitsina na sistemu krovi i kostnomozgovoe krovetvorenie v éksperimente.