The role of benzydamine in the topical treatment of the so-called non-specific vaginitis.
The authors report the preliminary results of their investigation of the efficacy of benzydamine in the treatment of the so-called non-specific vaginitis. An initial in vitro study to test its bacteriostatic and/or bactericidal activity on Gardnerella vaginalis showed that the drug has high activity even at the lowest concentrations, and completely inhibits this micro-organism at 1000 micrograms/ml which is the usual concentration employed in therapy. The first pilot study performed in vivo on 14 selected vaginitis cases which were found positive for G. vaginalis by culture test appears to confirm the therapeutic efficacy of benzydamine; however, this confirmation must await the results of a double-blind clinical trial which is still in progress.
D000282:Administration, Intravaginal; D000328:Adult; D001591:Benzydamine / Q000008:administration & dosage*; D005260:Female; D006194:Gardnerella vaginalis / Q000187:drug effects / Q000302:isolation & purification; D006192:Haemophilus Infections / Q000188:drug therapy*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000008:administration & dosage*; D014627:Vaginitis / Q000188:drug therapy* / Q000382:microbiology
D011720:Pyrazoles; D001591:Benzydamine