[Neurohormonal and immunological status of patients with autoimmune thrombocytopenic purpura].
A study was made of the relationship between hormonal (ACTH, cortisol, TSH, T3, T4, STH) and immune (E-RFC, EAC-RFC, and immunoglobulins) shifts in the time course of therapy in 106 patients with autoimmune thrombocytic purpura. A significant decrease in the level of T3 and its direct correlation with E-RFC in exacerbation of disease combined with an increase in the levels of cortisol and IgM were revealed. The treatment with glucocorticoids and immunosuppressants resulted in a more noticeable decrease in the levels of T3 and E-RCF. In case of development of hematological remission splenectomy resulted in the normalization of these shifts. In splenectomized patients with immunosuppressive therapy-refractory recurrences there was again a decrease in the level of T3 whereas the level of E-RCF was even on an increase.
D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007075:Immunoglobulin M / Q000032:analysis*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011696:Purpura, Thrombocytopenic / Q000097:blood / Q000276:immunology* / Q000628:therapy; D012397:Rosette Formation; D013156:Splenectomy; D013601:T-Lymphocytes / Q000276:immunology; D014284:Triiodothyronine / Q000097:blood*
D005938:Glucocorticoids; D007075:Immunoglobulin M; D007166:Immunosuppressive Agents; D014284:Triiodothyronine; D006854:Hydrocortisone
Neĭrogormonal'nyĭ i immunologicheskiĭ status bol'nykh autoimmunnoĭ trombotsitopenicheskoĭ purpuroĭ.