title: Anti-epidermal growth factor receptor monoclonal antibodies may inhibit A431 tumor cell proliferation by blocking an autocrine pathway.
abstract: Monoclonal antibodies which bind to the EGF receptor have the capacity to inhibit EGF-induced effects upon proliferation and biochemical functions in cultured human cells. Some EGF receptor-bearing tumor cells are prevented from growth by treatment with antireceptor antibody. Evidence is presented which suggests that antibody-mediated antiproliferative activity may result from effects upon growth factor-dependent processes in the receptor-bearing cells.
mesh_terms: D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell; D002455:Cell Division; D002460:Cell Line; D004815:Epidermal Growth Factor / Q000502:physiology; D066246:ErbB Receptors / Q000276:immunology* / Q000502:physiology; D006801:Humans
chemical_list: D000911:Antibodies, Monoclonal; D004815:Epidermal Growth Factor; D066246:ErbB Receptors