The application of positron emission tomography to the study of panic disorder.
Positron emission tomography was used to study eight patients with panic disorder who were vulnerable to lactate-induced panic, eight patients with panic disorder who were not vulnerable to lactate-induced panic, and 25 normal control subjects. Patients who were vulnerable to lactate-induced panic had several abnormalities in the resting, nonpanic state: an abnormal hemispheric asymmetry of parahippocampal blood flow, blood volume, and oxygen metabolism; abnormally high whole brain metabolism; and abnormal susceptibility to episodic hyperventilation. A hypothetical model for the neurobiology of panic disorder, involving the abnormal parahippocampal region and its afferent and efferent connections, is proposed.
D000328:Adult; D001008:Anxiety Disorders / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D002248:Carbon Monoxide / Q000097:blood; D002560:Cerebrovascular Circulation; D005239:Fear; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007263:Infusions, Parenteral; D007773:Lactates / Q000008:administration & dosage; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D010200:Panic; D014055:Tomography, Emission-Computed
D007773:Lactates; D019344:Lactic Acid; D002248:Carbon Monoxide; D010100:Oxygen