Interleukin 1 inhibitory activity secreted by a human myelomonocytic cell line (M20).
Culture supernatants from a myelomonocytic cell line (M20) were found to inhibit interleukin 1 (IL 1) activity in vitro. The factor, isolated from these supernatants, inhibited augmentation of phytohemagglutinin response of mouse thymus cells induced by IL 1 derived from several established cell lines. Various IL 1-dependent activities such as lymphocyte and fibroblast proliferation in vitro were also inhibited by the factor. The factor did not inhibit IL 2-induced or other proliferative responses not related to IL 1. Preliminary biochemical characterization of the factor indicated that the activity resides in a protein with a molecular mass of 52 kDa.
D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003864:Depression, Chemical; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis / Q000037:antagonists & inhibitors*; D007376:Interleukin-2 / Q000032:analysis; D007951:Leukemia, Myeloid / Q000378:metabolism / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects; D008222:Lymphokines / Q000378:metabolism* / Q000494:pharmacology; D009000:Monocytes / Q000378:metabolism*; D010835:Phytohemagglutinins / Q000494:pharmacology
D007375:Interleukin-1; D007376:Interleukin-2; D008222:Lymphokines; D010835:Phytohemagglutinins