Is remission of Graves' disease regulated by anti-idiotypic antibodies?
Our results show evidence for regulation of Graves' disease remission by anti-idiotypic antibodies in a biologic assay. The polyclonality and functional heterogeneity of thyroid receptor antibodies is most likely the reason why evidence for idiotypic-anti-idiotypic regulation can be demonstrated in the autologous but not consistently in the homologous system.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D051379:Mice; D008819:Mice, Nude; D012075:Remission, Spontaneous; D013961:Thyroid Gland / Q000276:immunology* / Q000637:transplantation; D014183:Transplantation, Heterologous
D000888:Antibodies, Anti-Idiotypic; D007130:Immunoglobulin Idiotypes