Metabolism of epidoxorubicin in animals: absence of glucuronidation.
Metabolism of epidoxorubicin was studied in plasma of seven different animal species at 2 h after administration of 4 mg/kg. None of the animals showed significant glucuronidation of epidoxorubicin, although small amounts of the glucuronides could be detected in the rabbit. However, large differences in formation of epidoxorubicinol and 7-deoxy (7d) doxorubicinol aglycone were observed between the species. These phenomena may be relevant for interspecies differences with regard to anthracycline-induced histomorphological changes in for example, heart tissues and cardiotoxicity in relation to formation of 7d aglycones.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004317:Doxorubicin / Q000097:blood / Q000378:metabolism*; D015251:Epirubicin; D005966:Glucuronidase / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D015251:Epirubicin; D004317:Doxorubicin; D005966:Glucuronidase