Interleukin-2 production by lymphocytes from blood of children with arthritis is less suppressed than in systemic lupus or cystic fibrosis.
Interleukin-2 (IL-2) production by cells from children with various forms of arthritis, systemic lupus erythematosus, and cystic fibrosis was compared. In all cases more IL-2 was detectable at 24 than at 48 h and production was increased by addition of indomethacin. Cultures from children with either active lupus or the pneumonia of cystic fibrosis produced very little IL-2, but cultures from children with arthritis produced apparently normal amounts. We conclude that depressed production of IL-2 in juvenile arthritis may be a secondary epiphenomenon and not a primary immunologic deficit.
D001171:Arthritis, Juvenile / Q000097:blood* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism*
D007376:Interleukin-2