PGD2 induces pulmonary hyperresponsiveness to acetylcholine in vivo in the guinea-pig.
1 A threshold dose of Prostaglandin D2 (PGD2) (0.5 microgram/kg i.v.), which did not modify the basal values of airway resistance, potentiated the acetylcholine induced bronchospasm in anaesthetized guinea-pigs. 2 beta-adrenoreceptors blockade induced by propranolol enhanced the positive interaction between PGD2 and acetylcholine in the pulmonary dynamics. 3 Active sensitization of guinea-pigs by ovalbumin increased the pulmonary PGD2-acetylcholine interaction and the phenomenon was sustained during the time. 4 The inability of PGD2 to potentiate histamine-induced bronchoconstriction suggests a specificity for the interaction.
D000109:Acetylcholine / Q000494:pharmacology*; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001986:Bronchial Spasm / Q000139:chemically induced; D004357:Drug Synergism; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D011433:Propranolol / Q000494:pharmacology; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000494:pharmacology*; D012130:Respiratory Hypersensitivity / Q000139:chemically induced*
D011457:Prostaglandins D; D006632:Histamine; D010047:Ovalbumin; D011433:Propranolol; D000109:Acetylcholine; D015230:Prostaglandin D2