title: [Immunological studies of aging and the family in gastric cancer, with special reference to cell-medical immunity].
abstract: Cell-mediated immunity of the aging and immune response in the family of gastric cancer have been investigated and the following results were obtained. Immune response particularly of cell-mediated immunity was found decreased in paralled with aging; decreases in peripheral lymphocyte and T-cell counts, rate of Con A and PHA induced blastoid transformation, and the tendency of increase in suppressor T-cell were noted. Investigations on the immune response in the family of gastric cancer revealed that cell-mediated immune response was recreased in the compared to age-matched healthy volunteers. These findings suggest that latent immunological failure may exist in the above family.
mesh_terms: D000368:Aged; D000375:Aging / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
chemical_list: D006680:HLA Antigens