Neutrophilic eccrine hidradenitis in acute myelomonocytic leukemia.
Neutrophilic eccrine hidradenitis is a rare but distinct dermatosis that has recently been described in adults with acute myelogenous leukemia. We report the first pediatric case in an 11-year-old girl with acute myelomonocytic leukemia who developed this eruption following her first and second course of VAPA-10 induction chemotherapy. Skin biopsy revealed selective neutrophilic infiltration around the eccrine coils, which is characteristic of this dermatosis. The clinical and biopsy findings of our patient are presented and compared with the previous three reported cases.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D004439:Eccrine Glands / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D012074:Remission Induction; D013543:Sweat Gland Diseases / Q000139:chemically induced* / Q000473:pathology; D013545:Sweat Glands / Q000187:drug effects*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
D003561:Cytarabine; D014750:Vincristine; D004317:Doxorubicin; D011239:Prednisolone