Three subtypes of chronic schizophrenia identified using 11C-glucose positron emission tomography.
The authors used positron computed tomography (CT) and 11C-labeled glucose to measure brain glucose utilization in 20 chronic schizophrenic patients (18 men, 2 women, mean age 38) and 5 male control subjects (mean age 38). Positron emission tomography (PET) revealed at least three subtypes: hypofrontal (type A), hypoparietal (right-sided disturbance in right-handed and left-sided disturbance in left-handed patients) (type B), and normal (type C). The significant count reduction in the frontal lobe (Brodmann's area 10) in type A patients was 38%, while that in the parietal lobe (Brodmann's area 40) in type B patients was 26% in each lobe of the brain.
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000378:metabolism; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D014055:Tomography, Emission-Computed
D000596:Amino Acids; D002250:Carbon Radioisotopes; D005947:Glucose