Effect of systemic intravenous infusion of PGF-2 alpha and 13,14-dihydro-15-keto-PGF-2 alpha on the release of oxytocin-associated neurophysin from the ovary in the ewe.
Systemic intravenous infusion of physiological concentrations of PGF-2 alpha and its major metabolite, 13, 14-dihydro-15-keto-PGF-2 alpha (PGFM) into non-pregnant ewes possessing a corpus luteum induced the release of oxytocin-neurophysin. These results suggest that, during luteolysis, endogenous release of uterine PGF-2 alpha would be able to stimulate the release of ovarian oxytocin and oxytocin-neurophysin from the ovary.
D000818:Animals; D015237:Dinoprost / Q000031:analogs & derivatives; D004971:Estrus; D005260:Female; D007044:Hysterectomy; D009481:Neurophysins / Q000097:blood / Q000378:metabolism*; D010052:Ovariectomy; D010053:Ovary / Q000187:drug effects / Q000378:metabolism*; D011460:Prostaglandins F / Q000494:pharmacology*; D012756:Sheep
D009481:Neurophysins; D011460:Prostaglandins F; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D015237:Dinoprost