Construction of a novel oncogene based on synthetic sequences encoding epidermal growth factor.
The autocrine model postulates that constitutive release of a mitogenic growth factor can lead to uncontrolled proliferation and cell transformation. A synthetic polynucleotide encoding epidermal growth factor conferred a tumorigenic phenotype on cells. These cells were transformed through the action of an autocrine circuit having an extracellular component.
D000818:Animals; D000911:Antibodies, Monoclonal; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D004274:DNA, Recombinant; D004815:Epidermal Growth Factor / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000276:immunology; D005786:Gene Expression Regulation; D051379:Mice; D009374:Neoplasms, Experimental / Q000235:genetics / Q000473:pathology; D009857:Oncogenes; D051381:Rats; D014162:Transfection
D000911:Antibodies, Monoclonal; D004274:DNA, Recombinant; D004815:Epidermal Growth Factor