The effect of cotrimoxazole on the absorption of orally administered 6-mercaptopurine in the rat.
The effect of cotrimoxazole (CTX) on plasma levels of 6-mercaptopurine (6-MP) was studied in the rat. Animals receiving CTX in conjunction with 6-MP were found to have a marked but non-significant decrease in the area under the plasma time curve as compared with animals receiving 6-MP alone. It is suggested that the bioavailability and thereby, the antileukaemic effect) during maintenance therapy of ALL of 6-MP may be decreased by the co-administration of CTX.
D000284:Administration, Oral; D000818:Animals; D004338:Drug Combinations / Q000494:pharmacology; D004347:Drug Interactions; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage / Q000378:metabolism*; D008657:Metabolic Clearance Rate / Q000187:drug effects; D051381:Rats; D013420:Sulfamethoxazole / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D015122:Mercaptopurine; D013420:Sulfamethoxazole