Late cortical cerebellar atrophy. Clinical and oculographic features.
Ten patients with late cortical cerebellar atrophy documented with computerized tomography (CT) and magnetic resonance (MR) imaging presented a uniform pattern of oculomotor abnormalities. All had deficits in smooth pursuit and fixation suppression of the vestibulo-ocular reflex (VOR). The gain of the VOR was often increased but the dynamics of the VOR were not different from normals. Full-field optokinetic responses and visual-vestibular interaction mediated via the VOR velocity storage element were preserved. Just as in lower primates, the cerebellum in humans is a critical relay station for foveal pursuit and visual-vestibular interaction requiring foveal pursuit. Vestibular responses and visual-vestibular interaction mediated through the VOR velocity storage element are relatively independent of the cerebellum.
D000328:Adult; D000368:Aged; D001284:Atrophy; D002524:Cerebellar Ataxia / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D005133:Eye Movements; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009760:Nystagmus, Physiologic; D012018:Reflex; D014057:Tomography, X-Ray Computed; D014722:Vestibule, Labyrinth / Q000473:pathology / Q000503:physiopathology; D014785:Vision, Ocular / Q000502:physiology