Gastric prostaglandin E2 release induced by aluminium hydroxide and aluminium hydroxide-containing antacids in rats. Effect of low doses and citric acid.
Suspensions of aluminium hydroxide or a commercial antacid containing aluminium hydroxide (Trigastril) was instilled intragastrically in rats in doses comparable to high and low human therapeutic doses (aluminium hydroxide, 125 mg and 12.5 mg/kg, respectively). Corresponding experiments were carried out with 0.6% citric acid added to the antacid suspensions. Prostaglandin E2 (PGE2) in the gastric content was analysed by radioimmunoassay 6 h after drug administration. Both high and low doses of aluminium hydroxide and Trigastril increased the concentration of PGE2 significantly. Citric acid did not significantly affect the antacid-induced PGE2 release except in combination with a low dose of aluminium hydroxide, with which a significant increase was seen. Release of PGE2 by low doses of antacids implies the possibility that enhanced cytoprotection may be involved in the mechanism by which antacids promote the healing of peptic ulcers.
D000536:Aluminum Hydroxide / Q000008:administration & dosage*; D000818:Animals; D000863:Antacids / Q000008:administration & dosage*; D002119:Calcium Carbonate / Q000008:administration & dosage*; D002951:Citrates / Q000494:pharmacology*; D019343:Citric Acid; D015232:Dinoprostone; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000008:administration & dosage; D005750:Gastric Juice / Q000032:analysis; D008274:Magnesium / Q000008:administration & dosage*; D008276:Magnesium Hydroxide / Q000008:administration & dosage*; D008297:Male; D011458:Prostaglandins E / Q000032:analysis / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains
D000863:Antacids; D002951:Citrates; D004338:Drug Combinations; D011458:Prostaglandins E; D019343:Citric Acid; C007565:aluminum hydroxide, calcium carbonate, magnesium hydroxide drug combination; D000536:Aluminum Hydroxide; D002119:Calcium Carbonate; D008274:Magnesium; D015232:Dinoprostone; D008276:Magnesium Hydroxide