Extrathyroidal synthesis and biologic action of thyroid receptor antibody (TRAb) in Graves' disease.
In a patient with Graves' disease who underwent thyroidectomy with subsequent radioiodine therapy thyroid receptor antibody could be detected by radioligand assay. No thyroid tissue could be detected by 131I-scintiscanning. Thyroglobulin was repeatedly negative. Biologic activity of this patients serum could be demonstrated in the nude mice bio assay. 131I-incorporation and secretion of human thyroglobulin could be stimulated by injecting thymusdysplastic nude mice with transplants of thyroid tissue from a patient with Graves' disease with the athyroid patients serum. These results demonstrate evidence for extrathyroidal production and biological activity of TRAb in vivo.
D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D005260:Female; D006111:Graves Disease / Q000276:immunology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D007457:Iodine Radioisotopes; D011988:Receptors, Thyroid Hormone / Q000276:immunology*; D013954:Thyroglobulin / Q000032:analysis; D013965:Thyroidectomy
D001323:Autoantibodies; D007457:Iodine Radioisotopes; D011988:Receptors, Thyroid Hormone; D013954:Thyroglobulin