title: Accommodation of rat nigrostriatal dopamine neurones to high frequency electrical stimulation of the median forebrain bundle: in vivo voltammetric data.
abstract: The frequency response of nigrostriatal neurones to electrical stimulation of the median forebrain bundle was investigated in vivo using high-speed cyclic voltammetry to measure the evoked striatal dopamine overflow. It was found that the nerves could follow 25-50 Hz stimulation for at least 10 s, whereas the neurones were unable to respond to high frequencies (100-200 Hz) for more than 1-3 s. Accommodation, due to incomplete re-equilibration of ionic fluxes between successive stimuli, provides a possible explanation for these findings.
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D003342:Corpus Striatum / Q000166:cytology / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D004558:Electric Stimulation / Q000379:methods; D004594:Electrophysiology; D008297:Male; D008474:Medial Forebrain Bundle / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000166:cytology / Q000502:physiology*; D013997:Time Factors
chemical_list: D004298:Dopamine