title: Isotope computed tomography using cone-beam geometry: a comparison of two reconstruction algorithms.
abstract: A CT scanner has been constructed specifically to determine the three-dimensional distribution of bone mineral in the medullary cavities of the radius, ulna and femur. A source of x-rays (153Gd) and a multiwire proportional counter (MWPC) are mounted at opposite ends of a diameter of an annular mounting. The limb is placed on the axis of rotation of the annulus and a series of two-dimensional transmission projections are obtained at equal angular spacings over 360 degrees. The distribution of bone mineral is reconstructed from the projections either by the method of maximum entropy (ME) or by convolution and back projection (CBP). These two methods have been evaluated by reconstructing a single slice of a phantom, representing the forearm, from projections simulated by computer. With a clinically acceptable exposure time, the mean medullary densities of the ulna and radius were determined with systematic errors of less than 3.5% (ME) and 11% (CBP), although for the latter method of reconstruction the systematic error was reduced to less than 2% by increasing the number of views. The mean medullary densities of the ulna and radius were determined with precisions better than 2.5% (ME) and 3.5% (CBP).
mesh_terms: D000465:Algorithms; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D005682:Gadolinium; D006801:Humans; D008903:Minerals / Q000032:analysis; D011859:Radiography; D011868:Radioisotopes; D014055:Tomography, Emission-Computed / Q000295:instrumentation / Q000379:methods*
chemical_list: D008903:Minerals; D011868:Radioisotopes; D005682:Gadolinium