DNA changes during blastic transformation in chronic granulocytic leukemia.
Immunoglobulin and T cell receptor gene mapping were undertaken in 10 patients during both chronic and blastic phases of chronic granulocytic leukemia. Twenty percent were shown to undergo lymphoblastic transformation. DNA changes did not predict blastic transformation or those who would respond favourably to treatment with vincristine and prednisone.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001752:Blast Crisis / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009710:Nucleotide Mapping; D011446:Prospective Studies; D011948:Receptors, Antigen, T-Cell / Q000235:genetics
D004273:DNA, Neoplasm; D007136:Immunoglobulins; D011948:Receptors, Antigen, T-Cell