[Prostaglandin E2 liberation in the synovial fluid induced by organo-iodinated contrast media. Interrelations with the genesis of post-arthrographic pain].
RCM have been observed to cause--during arthrography--the appearance of a slow onset painful symptomatology with the clinical characteristics of a slight and transient acute arthritis. These substances are supposed to set in a production of humoral mediators of inflammation with algogenic action--PGE2 in particular. During arthrography of the knee the release of synovial fluid PGE2 after RCM introduction was studied. Two RCM were compared: meglumine iothalamate and iopamidol. Twenty patients underwent arthrography of the knee: synovial fluid PGE2 concentration was measured both before and 15' after RCM introduction with 125I-RIA method. Results show a significant increase in PGE2 concentration after both iothalamate (p less than 0.0001) and iopamidol (p less than 0.01) --especially in iothalamate--treated patients (p less than 0.01). A physiopathologic mechanism about post-arthrographic pain and, more generally, about RCM toxicity is thus hypothesized.
D001175:Arthrography / Q000009:adverse effects*; D015232:Dinoprostone; D006801:Humans; D007479:Iopamidol / Q000009:adverse effects*; D007482:Iothalamate Meglumine / Q000009:adverse effects*; D007719:Knee Joint / Q000000981:diagnostic imaging; D010146:Pain / Q000209:etiology* / Q000503:physiopathology; D011458:Prostaglandins E / Q000032:analysis* / Q000502:physiology; D011863:Radioimmunoassay; D013582:Synovial Fluid / Q000032:analysis*
D011458:Prostaglandins E; D007479:Iopamidol; D015232:Dinoprostone; D007482:Iothalamate Meglumine
Liberazione di prostaglandina E2 nel liquido sinoviale indotta da mezzi di contrasto organoiodati. Interrelazione con la genesi del dolore postartrografico.