The Copenhagen high-risk project. The diagnosis of maternal schizophrenia and its relation to offspring diagnosis.
The Copenhagen longitudinal high-risk study of offspring of 129 schizophrenic mothers commenced in 1962. At that time, the mothers were diagnosed according to contemporary Danish criteria. We have re-examined all of the hospital records of these mothers: 108 (84%) fulfil present-day DSM-III criteria for schizophrenia and 95 (74%) were diagnosed as paranoid schizophrenic according to ICD-8 criteria. In a follow-up at mean age 24, the offspring of the paranoid schizophrenic mothers were themselves found to be less frequently schizophrenic (5%) than were the offspring of non-paranoid schizophrenic mothers (29%).
D000328:Adult; D002648:Child; D002675:Child, Preschool; D003718:Denmark; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009035:Mothers; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012563:Schizophrenia, Paranoid / Q000235:genetics