title: Portal vein thrombosis following combined endoscopic variceal sclerosis and vasopressin therapy for bleeding varices.
abstract: We report the occurrence of acute portal vein thrombosis in three patients undergoing endoscopic variceal sclerosis (EVS) for bleeding esophageal varices. All patients received intravenous vasopressin in close proximity to or at the time of EVS. By increasing flow of sclerosant caudally into gastric veins during EVS, vasopressin may predispose to retrograde propagation of thrombus into the portal venous system. Combined use of vasopressin and EVS for treatment of bleeding esophageal varices should be undertaken with caution.
mesh_terms: D000208:Acute Disease; D004932:Esophageal and Gastric Varices / Q000628:therapy*; D006471:Gastrointestinal Hemorrhage / Q000628:therapy*; D006801:Humans; D008297:Male; D008641:Mesenteric Vascular Occlusion / Q000209:etiology; D008642:Mesenteric Veins; D008875:Middle Aged; D011169:Portal Vein; D012597:Sclerosing Solutions / Q000009:adverse effects* / Q000627:therapeutic use; D013927:Thrombosis / Q000209:etiology*; D014667:Vasopressins / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D012597:Sclerosing Solutions; D014667:Vasopressins