[Relation of the formation of producers of antigen-dependent nonspecific immunoglobulins to the dose of T-dependent and T-independent antigens].
The dependence of the production of antibody-forming cells (AFC) and non-specific immunoglobulin-forming cells (nIFC) on the doses of T-dependent (sheep red blood cells, SRBC) and T-independent (polyvinylpyrrolidone, PVP and pneumococcal polysaccharide SSS III) antigens was investigated. The immunization of BALB/c mice with immunogenic or subimmunogenic doses of SRBC and PVP induced a marked increase in the number of antigen-dependent nIFC. In contrast, the injection of any SSS III doses did not influence the amount of nIFC, although a specific immune response to SSS III was quite obvious. Thus, two T-independent antigens, type II, differ in their ability to induce non-specific immune reactions. The experiments on simultaneous administration of monoclonal anti-Thy-1.2 antibodies and PVP or SSS III to mice have demonstrated that these differences were not related to T-suppressor activity. The possible role of T helpers in the immune response to T-independent antigens is discussed.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D007114:Immunization; D007136:Immunoglobulins / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D011135:Polysaccharides, Bacterial / Q000276:immunology; D011205:Povidone / Q000276:immunology; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D007136:Immunoglobulins; D011135:Polysaccharides, Bacterial; C026604:pneumococcal polysaccharide, type III; D011205:Povidone
Zavisimost' obrazovaniia produtsentov antigenzavisimykh nespetsificheskikh immunoglobulinov ot dozy T-zavisimogo i T-nezavisimykh antigenov.