[Regional cerebral blood flow in brain tumors analyzed by N-isopropyl-(123I)-p-iodoamphetamine (IMP)].
N-Isopropyl-(123I)-p-Iodoamphetamine (IMP), a newly developed tracer for regional cerebral blood flow, was applied to 18 patients with brain tumors. The static scan images were obtained by a single photon emission CT 20 minutes after IMP injection, and revealed decreased IMP uptake in the tumor region in 17 out of 18 patients. This result suggests the lack of an IMP-trapping mechanism in the tumor. In dynamic scan images, which were taken every 2 minutes just after IMP injection, IMP uptake in the tumor was intermediate between that of contralateral white matter and gray matter, and it increased momentarily in accordance with that of the gray and white matter. This finding indicates that the IMP uptake in a dynamic scan would express the regional tissue blood flow in the tumor.
D000368:Aged; D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D020367:Iofetamine; D008297:Male; D008875:Middle Aged; D014055:Tomography, Emission-Computed
D000662:Amphetamines; D020367:Iofetamine