The toxicity of recombinant human interleukin-2 in rats following intravenous infusion.
Studies of recombinant interleukin-2 (RIL-2) administered by continuous intravenous infusion revealed hepatocellular toxicity and redistribution of lymphoid cells. This finding was different from the normal findings seen in rats receiving comparable infusions of the vehicle.
D000818:Animals; D005260:Female; D007262:Infusions, Intravenous; D007376:Interleukin-2 / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D051381:Rats; D011916:Rats, Inbred F344; D011994:Recombinant Proteins / Q000633:toxicity
D007376:Interleukin-2; D011994:Recombinant Proteins