Mechanism of cytotoxicity of 2-chloro and 2-bromodeoxyadenosine for a human lymphoblastic cell line, CCRF-CEM.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D003839:Deoxyadenosines / Q000031:analogs & derivatives* / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007939:Leukemia L1210 / Q000201:enzymology; D008214:Lymphocytes / Q000187:drug effects*; D012262:Ribonucleoside Diphosphate Reductase / Q000037:antagonists & inhibitors
D003839:Deoxyadenosines; C050069:2-bromo-2'-deoxyadenosine; D004247:DNA; D012262:Ribonucleoside Diphosphate Reductase