[Antiproliferative effect of an extract of Aspergillus terreus].
We have studied antiproliferative effect of Aspergillus terreus extract on various cell lines: I-407 normal human cells, L-929 normal murine cells, K-562 erythroleukemic human cells, IAD lymphoblastoid human cells and B 95-8 monkey lymphoblastoid cells. K-562 and lymphoblastoid cells showed higher sensitivity to the extract. Moreover, "a cytostatic dose" of the extract on K-562 cells (12.5 micrograms/ml showed a reduction of 3H-thymidine (but not of 14C-uracil) incorporation, leading us to hypothesize a prevalent action on DNA synthesis.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001230:Aspergillus / Q000032:analysis*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D005347:Fibroblasts / Q000187:drug effects; D006131:Growth Inhibitors / Q000494:pharmacology*; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects; D008232:Lymphoproliferative Disorders / Q000473:pathology; D051379:Mice; D009183:Mycotoxins / Q000494:pharmacology*
D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D009183:Mycotoxins
Effetto antiproliferativo di un estratto di Aspergillus terreus.