title: Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively.
abstract: The gene for human prothrombin, or factor II (F2) has been assigned to 11p11-q12 by the combined use of a panel of somatic cell hybrid DNAs and in situ hybridization, using both cDNA and genomic probes. In addition, the cDNA probe for F2 recognizes a homologous sequence which has been tentatively mapped to the X chromosome. Similar approaches have been used to confirm the assignment of the ceruloplasmin gene, but to regionally localize it more proximally than previously reported (3q21-q24). These results provide further evidence that genes encoding the coagulation factors and related proteins are dispersed throughout the human genome.
mesh_terms: D002570:Ceruloplasmin / Q000235:genetics*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002893:Chromosomes, Human, Pair 3; D004247:DNA; D004274:DNA, Recombinant; D005796:Genes; D006801:Humans; D009693:Nucleic Acid Hybridization; D011516:Prothrombin / Q000235:genetics*
chemical_list: D004274:DNA, Recombinant; D011516:Prothrombin; D004247:DNA; D002570:Ceruloplasmin