Evidence for monoclonal T lymphocyte proliferation in angioimmunoblastic lymphadenopathy.
The arrangement of the T cell receptor and immunoglobulin genes was analysed in lymphoid tissue biopsy specimens from 25 cases of angioimmunoblastic lymphadenopathy. Nineteen cases showed a rearrangement of the gene coding for the beta chain of the T cell receptor, and in one case a clonal rearrangement of immunoglobulin genes was shown (in which the T cell receptor gene was in a germline configuration). These findings indicate that a monoclonal T cell proliferation is present in most cases of angioimmunoblastic lymphadenopathy, and they also correlate with the fact that some patients who present with this disorder subsequently develop a T cell lymphoma.
D002455:Cell Division; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000235:genetics* / Q000276:immunology; D007136:Immunoglobulins / Q000235:genetics; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
D007136:Immunoglobulins; D011948:Receptors, Antigen, T-Cell