title: Cerebrospinal fluid and serum immune complex in acute inflammatory polyneuritis. Detection by Clq binding assay.
abstract: Immune complexes (IC) were assessed in serum and CSF from 11 patients with acute inflammatory polyneuritis (AIP). An 125 I-labeled Clq binding assay (Clq BA) was used. IC were present in the sera of four patients and in the CSF of six. CSF-Clq BA of AIP (Group 1) were compared with 12 patients with other inflammatory neurological diseases (Group 2) and 22 patients with non-inflammatory neurological diseases (Group 3). There was only a significant difference between Group 1 compared to Group 3 (p less than 0.05). Serum and CSF IC did not correlate either with blood-brain barrier lesions or with immunoglobulin deposits in sural nerve biopsy.
mesh_terms: D000208:Acute Disease; D000936:Antigen-Antibody Complex / Q000134:cerebrospinal fluid*; D003166:Complement Activating Enzymes / Q000378:metabolism*; D015922:Complement C1q; D003168:Complement Fixation Tests; D006801:Humans; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000276:immunology; D011115:Polyneuropathies / Q000134:cerebrospinal fluid / Q000276:immunology*
chemical_list: D000936:Antigen-Antibody Complex; D015922:Complement C1q; D003166:Complement Activating Enzymes