title: Multimeric pattern discrepancy between platelet and plasma von Willebrand factor in type IIC von Willebrand disease.
abstract: von Willebrand factor (vWF) from platelet lysate and plasma, collected in the presence of protease inhibitors, was studied in two patients with type IIC von Willebrand disease (vWD). Platelet and plasma vWF showed the smallest multimer increased, but the latter had a repeating single band whereas the former had a repeating "doublet." This platelet-plasma discrepancy observed for the first time in these patients suggests that the repeating "doublet" or single band described in other type IIC patients represent minor subgroups of type IIC vWD.
mesh_terms: D001792:Blood Platelets / Q000032:analysis*; D006801:Humans; D014842:von Willebrand Diseases / Q000097:blood* / Q000145:classification; D014841:von Willebrand Factor / Q000032:analysis* / Q000145:classification
chemical_list: D014841:von Willebrand Factor