title: Androgen receptors in skeletal muscle cytosol from sheep treated with trenbolone acetate.
abstract: Female sheep were implanted with the anabolic agent trenbolone acetate and the effects of the treatment on the skeletal muscle androgen receptor studied. In two separate trials the binding capacity/mg skeletal muscle protein was reduced. In trial 1 the animals were implanted (80 mg trenbolone acetate) at the start and after 5 weeks of the trial and samples taken one week later while in the second trial samples were taken 15 days after a single implant (80 mg trenbolone acetate). The ability of a variety of steroids and steroid-like compounds to displace [3H] testosterone and [3H] methyltrienolone was also studied. The androgen receptor was also partially purified using heparin-sepharose chromatography The involvement of the anddrogen receptor in the mode of action of trenbolone is discussed.
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D002845:Chromatography; D003600:Cytosol / Q000378:metabolism; D004963:Estrenes / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D015741:Metribolone; D009132:Muscles / Q000378:metabolism*; D011944:Receptors, Androgen / Q000187:drug effects / Q000378:metabolism*; D012756:Sheep; D013739:Testosterone / Q000378:metabolism; D014204:Trenbolone Acetate / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D004963:Estrenes; D011944:Receptors, Androgen; D015741:Metribolone; D013739:Testosterone; D014204:Trenbolone Acetate