The structural gene for F liver protein (Flp) maps to chromosome 5 of the mouse.
The BXD and AKXL panels of recombinant inbred mouse strains have been typed for the F liver protein alloantigen. The structural gene for F liver protein gene (Flp) is placed on the distal part of chromosome 5, between the known markers Bcd-1 and Gus-s. This excludes the possibility that F liver protein is a major histocompatibility complex molecule, and in turn raises a question about the uniqueness of F and certain other proteins as purgers of self-reactivity among T but not B cells. The typed RI strains have then been used for the immunogenetic studies presented in the succeeding article.
D000818:Animals; D002874:Chromosome Mapping; D005796:Genes; D005819:Genetic Markers; D007519:Isoantigens / Q000235:genetics*; D008099:Liver / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity
D005819:Genetic Markers; D007519:Isoantigens; C030497:liver specific F antigen