title: Report of an informal meeting about alternative methods for the potency control of the diphtheria and tetanus components in vaccines.
abstract: On the 10th of December 1985 an informal meeting was organized at the National Institute of Public Health and Environmental Hygiene (RIVM) in Bilthoven to discuss the reduction of animals used in the potency control of the diphtheria and tetanus components in vaccines. The objectives of the meeting were to discuss alternative potency tests with some participants of the IABS-symposium on "Use and standardization of combined vaccines" and to make proposals for modifications in the WHO requirements. It has to be mentioned that the meeting was quite informal. The participants (Table I) continued the discussions which took place among a few of them in London 1985. Based on the discussions in London and Bilthoven there was an agreement on the following items.
mesh_terms: D000826:Animal Testing Alternatives; D000818:Animals; D004168:Diphtheria Toxoid / Q000592:standards*; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations / Q000592:standards; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D010567:Pertussis Vaccine / Q000592:standards*; D013745:Tetanus Toxoid / Q000592:standards*; D014944:World Health Organization
chemical_list: D004168:Diphtheria Toxoid; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid