title: The relationship between IgA antibodies to Streptococcus mutans antigens in human saliva and breast milk and the numbers of indigenous oral Streptococcus mutans.
abstract: The influence of indigenous Streptococcus mutans on naturally-occurring levels of IgA antibodies was studied in 42 lactating females. Breast milk, parotid and whole-saliva samples were collected and analysed by the ELISA method for IgA antibodies, reacting with antigens from Strep. mutans. All salivas and breast milk showed IgA antibody activity to five antigenic preparations from Strep. mutans and to a pool of Escherichia coli antigens. No correlation was observed between the IgA antibody level in breast milk and that in saliva. The total IgA in breast milk was, however, considerably higher than in the salivas. In subjects with active caries and subjects with high DMFS scores, there was a tendency toward lower levels of IgA antibodies in whole saliva than in subjects with low caries experience. The levels of specific IgA antibodies in saliva did not reflect the amount of indigenous Strep. mutans present in the mouth at the time of sampling.
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D000942:Antigens, Bacterial / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D008895:Milk, Human / Q000276:immunology*; D012463:Saliva / Q000276:immunology*; D013295:Streptococcus mutans / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007071:Immunoglobulin A, Secretory