Effect of anti-Ia treatment on the production of anti-DNA antibody by NZB mice.
A cell transfer system was used to study the effect of anti-Ia antibodies on anti-DNA-producing B cells. B cells from autoimmune New Zealand Black (NZB) mice were necessary and sufficient to transfer anti-DNA antibody production to congenic NZB. xid recipients. Anti-Ia treatment of either donors or recipients led to a significant reduction in the number of B cells secreting anti-DNA antibody. This effect was detectable after as little as 3 days of treatment and persisted for at least 1 month after the cessation of therapy. In this system, we could find no evidence of suppressor cell induction. These data suggest that anti-Ia antibodies directly suppress autoantibody-producing B lymphocytes.
D000818:Animals; D000906:Antibodies; D000974:Antibodies, Antinuclear / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D002455:Cell Division; D002999:Clone Cells; D004247:DNA / Q000276:immunology*; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology; D051379:Mice; D008814:Mice, Inbred NZB
D000906:Antibodies; D000974:Antibodies, Antinuclear; D000949:Histocompatibility Antigens Class II; D007075:Immunoglobulin M; D004247:DNA