2 dimensional flow cytometric analysis of activation antigens expressed on the synovial fluid T cells in rheumatoid arthritis.
Synovial fluid T cells expressed a higher percentage of all 3 activation antigens examined (anti-Ia antigen [HLA-DR]; antiinterleukin 2 receptor antigen [Tac], and antitransferrin receptor [TF-R] antigen) than the paired peripheral blood T cells obtained simultaneously from 19 patients with rheumatoid arthritis (RA) (p less than 0.001-0.05). A highly significant correlation was observed between disease activity and the percentage of Tac+ T cells in the synovial fluid from patients with RA (p less than 0.001).
D000328:Adult; D000368:Aged; D000941:Antigens / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001773:Blood Cells / Q000276:immunology; D002478:Cells, Cultured; D005434:Flow Cytometry / Q000379:methods*; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D008213:Lymphocyte Activation; D008875:Middle Aged; D013582:Synovial Fluid / Q000166:cytology*; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D000949:Histocompatibility Antigens Class II