Human CSF-1: gene structure and alternative splicing of mRNA precursors.
Bone marrow progenitor cells differentiate into mononuclear phagocytes in the presence of colony stimulating factor-1 (CSF-1). Characterization of the human CSF-1 gene shows that it contains 10 exons and 9 introns, which span 20 kb. Analysis of multiple CSF-1 transcripts demonstrates that alternate use of exon 6 splice acceptor sites and 3' noncoding sequence exons occurs. These alternatively spliced transcripts can encode either a 224 or a 522 amino acid CSF-1. Implications of differential splicing for the production and function of CSF-1 are discussed.
D000595:Amino Acid Sequence; D001483:Base Sequence; D002460:Cell Line; D003115:Colony-Stimulating Factors / Q000235:genetics*; D005091:Exons; D005796:Genes; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D012322:RNA Precursors / Q000235:genetics*; D012326:RNA Splicing; D014158:Transcription, Genetic
D003115:Colony-Stimulating Factors; D012322:RNA Precursors