title: [Synthesis and pharmacologic evaluation of some dihydropyran carboxylic acids].
abstract: The synthesis of three new dihydropyran carboxylic acids has been performed by uncommon procedures: cyanosilylation, cyclisation of oxime. Their chemical structure was confirmed by I.R. and N.M.R. data. In a pharmacological evaluation they were found to possess significant effects on the passive cutaneous anaphylaxis test and on the central nervous system; one of them showed an interesting antiallergic effect whilst another showed an interesting sedative effect.
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis*; D008297:Male; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D011714:Pyrans / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002264:Carboxylic Acids; D006993:Hypnotics and Sedatives; D011714:Pyrans
vernacular_title: Synthèse et évaluation pharmacologique de quelques acides dihydropyranne-carboxyliques.