Calcitonin gene-related peptide is a potent relaxant of intestinal muscle.
The motor effects of calcitonin gene-related peptide (CGRP) on the guinea-pig ileum (GPI) longitudinal muscle were investigated. CGRP (0.1-100 nM) concentration dependently relaxed ilea precontracted with histamine and inhibited electrically induced cholinergic contractions. At higher concentrations (3-100 nM) CGRP also caused a slight contraction of non-stimulated ilea. Further pharmacological analysis of the CGRP-induced relaxation which seems to be the primary CGRP effect in the GPI, indicated that the effect was due to a direct action on the longitudinal muscle.
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D009479:Neuropeptides / Q000494:pharmacology*
D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide