Radioiodinated free fatty acids; can we measure myocardial metabolism?
To investigate the feasibility of radioiodinated free fatty acids for 'metabolic imaging', the kinetics and distribution pattern of metabolites of 131I-heptadecanoic acid were studied in canine myocardium throughout metabolic interventions. In control dogs and in dogs during glucose/insulin and sodium lactate infusion, biopsy specimens were taken during a 90-min period after 131I-HDA administration and analyzed. Clearly distinct patterns of distribution and elimination were seen during the metabolic interventions, indicating the usefulness of iodinated fatty acids for metabolic studies.
D000818:Animals; D004285:Dogs; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D006321:Heart / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D007700:Kinetics; D009206:Myocardium / Q000378:metabolism*; D014055:Tomography, Emission-Computed
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D007457:Iodine Radioisotopes; C027252:17-iodoheptadecanoic acid