Interleukin-1 and interleukin-2 production in resistant and susceptible inbred mice infected with Trypanosoma congolense.
In vitro production of interleukin-1 (IL-1) by LPS-stimulated adherent peritoneal exudate and spleen cells and alveolar macrophages, and interleukin-2 (IL-2) by concanavalin A-stimulated splenocytes were measured in resistant (C57BL/6J) and susceptible (A/J) inbred mice during the early stages of subacute infections with the African trypanosome, Trypanosoma congolense. Production of IL-1 was severely depressed in both mouse strains as early as 24 hr after intraperitoneal injection of bloodstream trypanosomes. Similarly, in both mouse strains, an early decline in IL-2 activity was observed, followed by partial recovery then depression to subnormal levels. These changes in measurable IL-1 and IL-2 activity in infected mice concurred with progressive depression in the spleen cell proliferative response to the mitogen concanavalin A.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D004198:Disease Susceptibility; D005260:Female; D007108:Immune Tolerance; D007113:Immunity, Innate; D007375:Interleukin-1 / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008938:Mitosis; D051381:Rats; D013154:Spleen / Q000276:immunology; D014348:Trypanosoma congolense; D014353:Trypanosomiasis, African / Q000276:immunology*
D007375:Interleukin-1; D007376:Interleukin-2; D008070:Lipopolysaccharides; D003208:Concanavalin A