Gene transfer experiments to study T-cell recognition of MHC and antigen.
Gene transfer experiments are discussed which demonstrate the following: First, MHC-restricted antigen specificities of T lymphocytes are encoded by the alpha and beta T-cell receptor genes. Second, the interaction between cytotoxic T lymphocytes and their target cells is enhanced by the Lyt 2 molecule.
D000818:Animals; D000950:Antigens, Ly / Q000276:immunology; D008285:Major Histocompatibility Complex; D051381:Rats; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014162:Transfection
D000950:Antigens, Ly; D011948:Receptors, Antigen, T-Cell