Rôle of surfactant in peripheral transport mechanisms.
It has been demonstrated that compression and expansion of a monomolecular film lead to a unidirectional transport of particles which are present on this film. Using the same model we could demonstrate that Broncho-Alveolar Lavage fluids from healthy rats also produce a transport of particles in the direction of the compression phase and that lavage fluids from SO2 exposed rats show impaired and even reversed transport properties. In parallel there is a change of the phospholipid pattern in lavage fluid from SO2 exposed animals. The relevance of these observations is discussed for physiological and pathophysiological situations in the lung periphery.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001696:Biomechanical Phenomena; D001980:Bronchi / Q000378:metabolism; D008297:Male; D011663:Pulmonary Surfactants / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012137:Respiratory System / Q000378:metabolism*; D013458:Sulfur Dioxide / Q000494:pharmacology; D007507:Therapeutic Irrigation
D011663:Pulmonary Surfactants; D013458:Sulfur Dioxide