Monoclonal antibodies detecting plasminogen activators on the membrane of leukemic lymphoid cells of T-cell origin.
The specificities of six monoclonal antibodies produced against plasminogen activator of the human Bowes melanoma cell line are described. They have been used to detect membrane-bound plasminogen activator on cultured human lymphoid cell lines and in neoplastic human lymphocytic and myeloid cells of leukemic patients. These studies indicate that only certain phenotypic subsets of the T-cell lineage derived from patients with chronic lymphocytic leukemia or with Szezary syndrome express plasminogen activator on their surface membrane.
D000818:Animals; D000911:Antibodies, Monoclonal; D002460:Cell Line; D006801:Humans; D007938:Leukemia / Q000201:enzymology*; D008545:Melanoma / Q000201:enzymology; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D010960:Plasminogen Activators / Q000032:analysis* / Q000276:immunology; D011863:Radioimmunoassay; D013601:T-Lymphocytes / Q000201:enzymology*
D000911:Antibodies, Monoclonal; D010960:Plasminogen Activators