Effect of diclofenac sodium (Voltaren) and prostaglandin E2 on spermatogenesis in mature dogs.
The effect of the prostaglandin-synthesis inhibitor, diclofenac sodium (Voltaren), and of prostaglandin E2 (PGE2) on spermatogenesis in mature dogs has been studied. Diclofenac sodium at 2.0 mg/kg was given subcutaneously once a day for 42 days. The testes were biopsied every 7 days, and spermatogenesis was quantified showing a marked and statistically significant increase (p less than 0.001). Administration of PGE2 in doses of 2.0 mg/kg subcutaneously, once a day for 15 days, produced a marked and statistically significant decrease in spermatogenesis (p less than 0.001), and an increase in the numbers of exfoliated immature germ cells in the seminiferous tubule lumens.
D000818:Animals; D004008:Diclofenac / Q000494:pharmacology*; D015232:Dinoprostone; D004285:Dogs; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D012671:Seminiferous Tubules / Q000033:anatomy & histology; D013076:Sperm Count / Q000187:drug effects; D013087:Spermatids / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*
D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; D004008:Diclofenac; D015232:Dinoprostone