Inhibition of tumor growth in a mouse fibrosarcoma after interleukin 2 application.
Highly purified natural IL-2, obtained from induced human PBL's, was used to treat tumor-bearing mice. 3 X 10(6) vital cells of chemically induced fibrosarcoma BALB/c female Meth A were transplanted subcutaneously to female mice. Repeated injections of 10,000 U IL-2 into established tumors of 7-8 mm diameter led to complete rejections in 75% of the treated animals. Single intratumoral injections and other routes of the application of IL-2 did not significantly influence the tumor growth rate.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005354:Fibrosarcoma / Q000628:therapy*; D007376:Interleukin-2 / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C
D007376:Interleukin-2