title: Production of cartilage degrading activity by human synovial tissues.
abstract: Human synovial tissues have been assayed for the production of cartilage degrading activity (CDA). This activity is thought to be homologous with catabolin/interleukin 1 (IL1) produced by porcine synovium and leucocytes and by human leucocytes. The CDA of 26 rheumatoid (RA) and 41 non-rheumatoid synovia was measured on a dry weight basis. The rheumatoid synovia showed a threefold increase in activity over the non-rheumatoid, but there was no significant overall difference on a deoxyribonucleic acid (DNA) basis. The rheumatoid synovia appeared to consist of two populations; in over half the samples CDA was not related to cellularity, but eight patients had a high CDA and a high cellularity.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D002356:Cartilage / Q000187:drug effects*; D046508:Culture Techniques; D004247:DNA / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D053583:Interleukin-1beta; D013583:Synovial Membrane / Q000378:metabolism*
chemical_list: D007375:Interleukin-1; D053583:Interleukin-1beta; D004247:DNA; D005947:Glucose