Histocompatibility studies in pre-eclampsia.
Full HLA-A, B and DR types were obtained for 22 families (mothers, fathers and neonates) associated with severe (proteinuric) pre-eclampsia, 21 families associated with mild pre-eclampsia, and 132 families associated with normal pregnancies. There was an increased frequency of DR4 (relative risk 3.6: p less than 0.003, uncorrected) in both neonates and mothers of the severe pre-eclampsia families when compared to the normotensive controls. There were no significant differences between either pre-eclampsia group and controls in HLA antigen homozygosity, HLA antigen sharing or in lymphocytotoxin production.
D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D015804:HLA-DR4 Antigen; D006648:Histocompatibility; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D011225:Pre-Eclampsia / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D011247:Pregnancy
D006680:HLA Antigens; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen