Basal and lipopolysaccharide-inducible membrane alkaline phosphatase of lymphoid cells from mice with immune system dysfunctions.
The expression of membrane alkaline phosphatase (mAlPase) activity is an enzymatic marker of activated but not resting B cells which can be used on unseparated lymphoid cell suspensions. It is higher in lymphoid cell suspensions from mice with higher proportions of B cells (athymic mice) or with more activated B cells (autoimmune mice) than in those of control mice.
D000469:Alkaline Phosphatase / Q000096:biosynthesis / Q000378:metabolism*; D000818:Animals; D001327:Autoimmune Diseases / Q000201:enzymology*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D001853:Bone Marrow / Q000187:drug effects / Q000201:enzymology; D002462:Cell Membrane / Q000201:enzymology; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D008819:Mice, Nude / Q000276:immunology*; D013154:Spleen / Q000187:drug effects / Q000201:enzymology; D013950:Thymus Gland / Q000187:drug effects / Q000201:enzymology
D008070:Lipopolysaccharides; D000469:Alkaline Phosphatase