title: Naltrexone decreases self-injurious behavior.
abstract: The effect of naltrexone (0.5, 1.0, 1.5, and 2.0 mg/kg) on the frequency of self-injurious behavior (SIB) was investigated in three male adolescents. The frequency of total SIB was reduced significantly in all three subjects; dose-dependent decreases (at 0.5, 1.0, and 1.5 mg/kg) in SIB frequency were observed in the two mentally retarded subjects. These data suggest a role for opioid peptides in SIB.
mesh_terms: D000293:Adolescent; D002648:Child; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009271:Naltrexone / Q000627:therapeutic use*; D012652:Self Mutilation / Q000188:drug therapy* / Q000209:etiology; D005879:Tourette Syndrome / Q000150:complications / Q000188:drug therapy
chemical_list: D009271:Naltrexone