Bile salt reflux after cholecystectomy.
Gastric bile salt concentrations, the rates of bile salt reflux, gastric emptying, and gastric volume secretion were measured in 9 women with previous cholecystectomy and 13 unoperated female controls. The subjects were studied using a marker technique with gastric intubation both fasting and after gastric instillation of a mixed liquid meal. Cholecystectomy was without effect on gastric emptying and gastric volume secretion. Cholecystectomized patients had increased bile salt reflux rates (1.4 +/- 0.4 versus 0.6 +/- 0.2 mumol/min) and gastric bile concentrations (1753 +/- 266) versus 441 +/- 114 mumol/l) in the fasting state, but lower rates (0.3 +/- 0.3 versus 3.4 +/- 0.9 mumol/min) and concentrations (131 +/- 46 versus 496 +/- 123 mumol/l) after feeding. These findings can be explained by the changes of bile flow into the duodenum induced by cholecystectomy.
D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000502:physiology*; D001655:Bile Reflux / Q000503:physiopathology*; D001660:Biliary Tract Diseases / Q000503:physiopathology*; D002763:Cholecystectomy; D005260:Female; D005746:Gastric Emptying; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D008875:Middle Aged
D001647:Bile Acids and Salts