Dietary bovine antigens and immune complex formation after intravenous immunoglobulin in common varied immunodeficiency.
Previously we have shown that the sera of hypogammaglobulinemic patients may contain large amounts of antigenically intact foreign protein of dietary origin, presumably due to the absence of an adequate gastrointestinal secretory immune barrier. In these studies we show that the intravenous infusion of immunoglobulin in these patients may result in high levels of immune complexes postinfusion and that at least one constituent of these complexes is likely to be bovine casein.
D000361:Agammaglobulinemia / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000276:immunology / Q000378:metabolism*; D002364:Caseins / Q000097:blood / Q000276:immunology; D002417:Cattle; D003166:Complement Activating Enzymes / Q000032:analysis; D015922:Complement C1q; D003176:Complement C3 / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000627:therapeutic use*; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy / Q000276:immunology*; D007262:Infusions, Intravenous; D008892:Milk / Q000276:immunology / Q000378:metabolism; D011863:Radioimmunoassay
D000906:Antibodies; D000936:Antigen-Antibody Complex; D002364:Caseins; D003176:Complement C3; D007074:Immunoglobulin G; D015922:Complement C1q; D003166:Complement Activating Enzymes