Passive transfer of acquired resistance to Listeria monocytogenes infection is independent of mononuclear cell granuloma formation.
This study documents the formation of leukocyte foci in the livers of mice infused with either normal or immune T cells and then challenged intravenously with Listeria monocytogenes. The results show that the transfer of antilisterial resistance occurred before mononuclear cell granuloma formation and was associated instead with the appearance of foci of infiltrating lymphocytes and neutrophils. Numbers of these foci remained low in mice which received immune cells but increased progressively until death in mice which received normal cells. These findings do not support the previous hypothesis that a major component of acquired resistance against Listeria infection involves the rapid generation of mononuclear cell granuloma formation under the control of immune T cells.
D000818:Animals; D006099:Granuloma / Q000276:immunology / Q000473:pathology; D007116:Immunization, Passive; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008088:Listeriosis / Q000276:immunology* / Q000473:pathology; D008099:Liver / Q000382:microbiology / Q000473:pathology; D051379:Mice; D009504:Neutrophils / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors