title: The synthesis and biological evaluation of 7 beta-[2-(2-aminooxazol-4-yl)-2-Z-methoximinoacetamido]-cep halosporin antibiotics.
abstract: 7 beta-[2-(2-Aminooxazol-4-yl)-2-Z-methoximinoacetamido]-3-cep hem -4-carboxylic acids 12 and 13 were synthesized. The microbiological activity of 12 and 13 as well as the beta-lactamase stability of 12 were discussed. Both 12 and 13 were quite active against a wide variety of microorganisms although usually less active than cefotaxime.
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002439:Cefotaxime / Q000494:pharmacology; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D001618:beta-Lactamases; D002439:Cefotaxime