Comparative in vitro activity of imipenem against Haemophilus influenzae and Haemophilus parainfluenzae.
A microdilution broth method was used to test 77 clinical isolates of Haemophilus influenzae and Haemophilus parainfluenzae, including beta-lactamase-positive and -negative strains, for susceptibility to ampicillin, chloramphenicol, and imipenem. Except for ampicillin against beta-lactamase-producing strains (MIC for 90% of strains [MIC90], greater than or equal to 128 micrograms/ml), all three antimicrobial agents had comparable in vitro activity (MIC90, less than or equal to 1 microgram/ml) against these bacterial strains.
D000667:Ampicillin / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D006190:Haemophilus / Q000187:drug effects*; D006193:Haemophilus influenzae / Q000187:drug effects*; D015378:Imipenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology*; D001618:beta-Lactamases / Q000378:metabolism
D013845:Thienamycins; D002701:Chloramphenicol; D015378:Imipenem; D000667:Ampicillin; D001618:beta-Lactamases