Maternal plasma bicycling PGE2 levels following vaginal administration of prostaglandin E2 pessaries in full term pregnancies.
Plasma levels of bicyclic PGE2 (PGE2M) were measured after administration of a 5mg, PGE2 slow release hydrogel pessary and a 3mg vaginal tablet (Upjohn). Twenty-four women of low parity with favourable induction features were randomised to receive either the hydrogel pessary or the vaginal tablet. A single pessary was administered and amniotomy was performed after 4 hours. Augmentation with oxytocin was carried out after amniotomy if required. Both groups showed a rise in plasma PGE2 levels in keeping with the release profiles of the pessaries. Wide interindividual differences in absorption were found.
D000282:Administration, Intravaginal; D001643:Bridged Bicyclo Compounds / Q000097:blood*; D001952:Bridged-Ring Compounds / Q000097:blood*; D015232:Dinoprostone; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood*; D006801:Humans; D007700:Kinetics; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011273:Pregnancy, Prolonged / Q000097:blood*; D011458:Prostaglandins E / Q000008:administration & dosage / Q000378:metabolism*
D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D011458:Prostaglandins E; D015232:Dinoprostone