Production of cartilage degrading activity by human synovial tissues.
Human synovial tissues have been assayed for the production of cartilage degrading activity (CDA). This activity is thought to be homologous with catabolin/interleukin 1 (IL1) produced by porcine synovium and leucocytes and by human leucocytes. The CDA of 26 rheumatoid (RA) and 41 non-rheumatoid synovia was measured on a dry weight basis. The rheumatoid synovia showed a threefold increase in activity over the non-rheumatoid, but there was no significant overall difference on a deoxyribonucleic acid (DNA) basis. The rheumatoid synovia appeared to consist of two populations; in over half the samples CDA was not related to cellularity, but eight patients had a high CDA and a high cellularity.
D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D002356:Cartilage / Q000187:drug effects*; D046508:Culture Techniques; D004247:DNA / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D053583:Interleukin-1beta; D013583:Synovial Membrane / Q000378:metabolism*
D007375:Interleukin-1; D053583:Interleukin-1beta; D004247:DNA; D005947:Glucose