[Plasma membrane of thymocytes--home of specific glucocorticoid binding sites].
The incubation of rat thymocytes with 3H-cortisol in the presence of cortisol immobilized on polyvinylpyrrolidone (PVP-GC) produces a decrease in 3H-cortisol uptake by these cells. PVP-GC is shown to compete with cortisol for specific binding sites on thymocytes, without penetrating into cells. It is therefore, concluded that plasma membranes of thymocytes contain specific glucocorticoid binding sites.
D000818:Animals; D002462:Cell Membrane / Q000032:analysis*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000032:analysis*; D013601:T-Lymphocytes / Q000166:cytology*
D011965:Receptors, Glucocorticoid
Plazmaticheskaia membrana timotsitov--mesto lokalizatsii spetsificheskikh uchastkov sviazyvaniia gliukokortikoidov.