Impaired lymphocyte responsiveness to phytohaemagglutinin associated with the possession of HLA-B8/DR3.
An examination was made of blastogenic response to phytohaemagglutinin (PHA) in HLA-B8 and/or DR3 positive subjects and B8/DR3 negative individuals. Both B8 and DR3 antigens were associated with a depression of the response at all three doses of PHA used. The possession of both these antigens did not lead to a further depression of the response.
D006680:HLA Antigens / Q000032:analysis / Q000276:immunology*; D015795:HLA-B8 Antigen; D006681:HLA-D Antigens / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis / Q000276:immunology*; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008232:Lymphoproliferative Disorders / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology*
D006680:HLA Antigens; D015795:HLA-B8 Antigen; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II; D010835:Phytohemagglutinins