[7-Chloro(phenylthio)-4-phenylaminoquinolines. Study of its anti-inflammatory and analgesic activity].
Some 7-chloro(phenylthio)-4-phenylaminoquinolines substituted in the benzene rings were prepared and subject to the Winter test for potential antiinflammatory activity and the acetic acid test for analgesic activity. Derivative (I) was devoid of antiinflammatory properties but showed interesting analgesic activity although this was 30 times weaker than that of indomethacin used as reference substance. The DL50/DE50 ratio is greater than 16 for derivative (I) and 3 for indomethacin. The other compounds had no or only slight activity.
D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D004487:Edema / Q000188:drug therapy; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains
D000634:Aminoquinolines; D000894:Anti-Inflammatory Agents, Non-Steroidal
Chloro-7 (phénylthio)phénylamino-4 quinoléines. Etude de l'activité antiinflammatoire et analgésique.