title: Cerebrospinal fluid interleukin 1 like activity during chronic relapsing experimental allergic encephalomyelitis.
abstract: Cerebrospinal fluid (CSF) and plasma samples were taken from strain 13 guinea pigs in various stages of chronic relapsing experimental allergic encephalomyelitis (CREAE). The samples were assayed for interleukin 1 (IL-1) in the C3H/Hej mouse thymocyte assay. After removal of inhibitors, IL-1 was detectable in low amounts in plasma (5 U/ml) throughout the course of the disease but was raised in the acute phase (12 U/ml). CSF IL-1 was, however, only present in low amounts (6 U/ml) during the acute phase but was elevated (18 U/ml) during the chronic stages of CREAE. During the relapse phase levels of IL-1 correlated with the total leucocyte count in the CSF. On gel filtration of CSF, IL-1 activity eluted at approximately 15 kD and could not be attributed to leakage of plasma IL-1 during CSF puncture or IL-2 activity.
mesh_terms: D000818:Animals; D001681:Biological Assay; D002850:Chromatography, Gel; D002908:Chronic Disease; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000134:cerebrospinal fluid / Q000276:immunology*; D006168:Guinea Pigs; D007375:Interleukin-1 / Q000032:analysis / Q000134:cerebrospinal fluid*; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H
chemical_list: D007375:Interleukin-1