Substitution therapy with recombinant growth hormone (somatrem) in adults with growth hormone deficiency.
The effects of a 12-week period of substitution therapy with somatrem have been investigated in six adults with confirmed hGH deficiency. Five of the six patients experienced a subjective improvement, mentally and physically, but these improvements were not demonstrated when the patients were assessed objectively. No side-effects were reported. Serum procollagen III peptide increased in all patients and serum IGF-1 increased in five of the six patients.
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy* / Q000523:psychology; D013006:Growth Hormone / Q000031:analogs & derivatives* / Q000172:deficiency* / Q000627:therapeutic use; D006728:Hormones / Q000627:therapeutic use*; D019382:Human Growth Hormone; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use
D006728:Hormones; D011994:Recombinant Proteins; D019382:Human Growth Hormone; D013006:Growth Hormone