Production of interleukin-1 by mononuclear cells of newborns and their mothers.
The ability of peripheral blood mononuclear cells derived from newborn infants, their mothers and healthy adults to produce interleukin 1 (IL-1) was examined. It was found that newborn and maternal mononuclear cells have a normal capacity to produce IL-1. In addition, a lower stimulatory activity of IL-1 production was found in maternal serum, suggesting another mechanism for the suppression of the maternal immune system during pregnancy. Furthermore, evidence is presented on the existence of sex-related blocking factors in the maternal serum which affect IL-1 production.
D000328:Adult; D000818:Animals; D001681:Biological Assay; D001769:Blood; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000276:immunology*; D007375:Interleukin-1 / Q000096:biosynthesis*; D007962:Leukocytes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D049590:Postpartum Period / Q000276:immunology*; D011247:Pregnancy
D007375:Interleukin-1