HLA-DP antigens in patients with pauciarticular juvenile rheumatoid arthritis.
The distribution of the recently described HLA-DP antigens was examined in a population of patients with pauciarticular juvenile rheumatoid arthritis and iridocyclitis, in an attempt to further characterize the immunogenetically determined susceptibility to this disease. There was a significantly increased frequency of the HLA-DPw2 antigen in the patients compared with the controls (67% versus 34%; odds ratio 3.9, P = 0.003 by Fisher's exact test). Population studies and family studies showed that this association with HLA-DPw2 was not secondary to linkage disequilibrium with the previously defined HLA-D region markers of disease (HLA-DR5 and HLA-DRw8) in these patients. These data raise the possibility that susceptibility to this form of juvenile rheumatoid arthritis may be regulated by more than one HLA-linked gene.
D001171:Arthritis, Juvenile / Q000235:genetics*; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006682:HLA-DP Antigens; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; D015805:HLA-DR5 Antigen; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic; D014606:Uveitis, Anterior / Q000235:genetics
D006682:HLA-DP Antigens; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; D015805:HLA-DR5 Antigen; C041559:HLA-DR8 antigen; D000949:Histocompatibility Antigens Class II