Anti-ulcer activity of calcitonin gene-related peptide in rats.
Calcitonin gene-related peptide (CGRP, 5-10 micrograms/kg s.c.). reduced both incidence and degree of indomethacin- or acetylsalicylic acid (ASA) plus HCl-induced gastric as well as cysteamine-induced duodenal ulcers in rats. CGRP had no effect on ethanol-induced gastric lesions. The anti-ulcer activity of CGRP is most likely ascribable to its potent antisecretory properties.
D000818:Animals; D000897:Anti-Ulcer Agents; D015740:Calcitonin Gene-Related Peptide; D004381:Duodenal Ulcer / Q000517:prevention & control; D005260:Female; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000517:prevention & control
D000897:Anti-Ulcer Agents; D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide