Thalamic stimulation effects on reactive depression.
Depression was evaluated in 10 patients before and after therapeutic mesothalamic brain stimulation for chronic pain. Minnesota multiphasic personality inventory T scores for depression were high in all patients before stimulation. Scores were decreased in 8 of 10 patients with chronic deep brain stimulation, three of whom returned to normal. Pain relief was good to excellent in 9 of 10 patients. It is concluded that depression is secondary to pain or pain-inducing factors which implicate the catecholamine and serotonergic systems.
D000275:Adjustment Disorders / Q000628:therapy*; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004599:Electric Stimulation Therapy; D005260:Female; D006801:Humans; D008950:MMPI; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000523:psychology; D059408:Pain Management; D013788:Thalamus / Q000502:physiology*