Transplantation and morphological studies of primary and passaged murine radiation-induced myeloid leukaemias.
Myeloid leukaemia can be induced reproducibly in CBA/H male mice following X-irradiation. After serial passage of the leukaemic cells into syngeneic recipients, they grow faster and require fewer cells for a take. Transplantation of primary leukaemias requires high cell doses unlike passaged lines derived from them. Passaging at low cell doses retains their primary-like growth and morphological properties. It would seem that these low cell dose passages may be a more useful model which can be used for investigating the biology and therapeutic responses of myeloid leukaemia than routinely passaged cell lines.
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D002452:Cell Count; D004900:Erythroblasts / Q000473:pathology; D006098:Granulocytes / Q000473:pathology; D007951:Leukemia, Myeloid / Q000209:etiology / Q000473:pathology*; D007953:Leukemia, Radiation-Induced / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D013154:Spleen / Q000473:pathology