Loss of ciliary activity in organ cultures of rat trachea treated with lipo-oligosaccharide from Haemophilus influenzae.
Organ culture of rat trachea was used as an experimental model to examine the ability of lipo-oligosaccharide from Haemophilus influenzae to damage respiratory tract mucosal tissue. Lipo-oligosaccharide from two strains of H. influenzae produced a significant decrease in the ciliary activity of tracheal rings observed over a 3-5 day period. No loss of ciliary activity was observed with the lipid-free moiety of the lipo-oligosaccharide.
D000818:Animals; D002923:Cilia / Q000187:drug effects; D004731:Endotoxins / Q000494:pharmacology*; D005260:Female; D006193:Haemophilus influenzae; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D009924:Organ Culture Techniques; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D014132:Trachea / Q000187:drug effects* / Q000648:ultrastructure
D004731:Endotoxins; D008070:Lipopolysaccharides; C023023:lipid-linked oligosaccharides