Cyclosporine facilitates B-cell membrane immunoglobulin capping.
The immunomodulatory molecule cyclosporine was found to cause an early acceleration of the capping of mouse B-cell membrane immunoglobulin. This was most marked when the capping process was slightly retarded by keeping the cells at 32 degrees. This is a sign that the drug can cause B-cell membrane alterations. At lower drug doses they might not be as easily detected, but are nevertheless sufficient to inhibit the activation of some B cells by membrane immunoglobulin clustering.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D003524:Cyclosporins / Q000494:pharmacology*; D005260:Female; D007152:Immunologic Capping / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011947:Receptors, Antigen, B-Cell / Q000032:analysis / Q000276:immunology*; D013696:Temperature
D003524:Cyclosporins; D011947:Receptors, Antigen, B-Cell