title: Effect of acute nutritional deprivation on macrophage colony-stimulating factor and macrophage progenitor cells in mice.
abstract: The effect of short-term nutritional deprivation on host defenses and on the parameters of macrophage production was determined in outbred mice. Confirming previous data from this laboratory, initial experiments demonstrated that starved mice were relatively resistant to infection by Listeria monocytogenes as determined by spleen and liver bacterial counts. The number of macrophage progenitor cells in bone marrow rose slightly during a 72-h starvation period and returned to normal during refeeding. By contrast, the number of progenitor cells in spleens fell to 12% of the base line during starvation. The concentration of the macrophage colony-stimulating factor in serum decreased during starvation and returned to normal during refeeding. Additional experiments were performed to determine whether starved mice had increased parameters of macrophage production during listerial infection. The number of progenitor cells in the bone marrow and spleens of starved mice had increased compared with that of fed mice early in infection. Macrophage colony-stimulating factor levels in starved mice rose early and remained elevated during infection but were not as high as in fed mice. These data document the changes in the parameters of monocyte production during starvation and suggest that the number of macrophage progenitor cells may be related to increased resistance to L. monocytogenes.
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors / Q000502:physiology*; D005260:Female; D005508:Food Deprivation; D007111:Immunity, Cellular; D008088:Listeriosis / Q000276:immunology; D008099:Liver / Q000382:microbiology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D013154:Spleen / Q000166:cytology / Q000382:microbiology; D013997:Time Factors
chemical_list: D003115:Colony-Stimulating Factors