title: Transient suppression of the zymosan-induced chemiluminescence produced by bone marrow cells during a subcutaneous nonspecific inflammation in the mouse.
abstract: The oxidative metabolism of remote phagocytes has been studied during the course of an acute nonspecific inflammation in the mouse. The bone marrow cells (BMC) from mice bearing a polyacrylamide-microbead-induced granuloma (Biogels P4 and P100) show a transient striking decrease of their chemiluminescence (CL) response to opsonized zymosan. This decreased oxidative response occurs between the third and 72nd hr, with a minimum observed at the 24th hr. Bone marrow granulocytes are assessed to represent the main chemiluminescent BMC compartment, using complement-mediated cytotoxicity assays with a monoclonal antimouse granulocyte antibody. Biogel P4-treated mice, but not Biogel P100-treated ones, show at the 24th hr a significantly decreased percentage of segmented bone marrow granulocytes (-45%, P less than .001). The accurate mechanisms involved in this transient suppression of stimulus-induced CL produced by BMC remain to be elucidated.
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology*; D006099:Granuloma / Q000139:chemically induced / Q000503:physiopathology*; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology*; D008163:Luminescent Measurements; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D015054:Zymosan / Q000494:pharmacology*
chemical_list: D000180:Acrylic Resins; C046089:Bio-Gel P-4; D015054:Zymosan