Biological and biochemical characteristics of the basophil-like cell promoting activity (BaPA) and a human IL 3-like activity.
Two growth factors isolated from lectin-stimulated human mononuclear cells stimulate the long-term growth of metachromatically staining cells in human bone marrow cultures. One factor, termed basophil-like cell promoting activity, induces also differentiation of cells which morphologically and functionally resemble human basophils. A second factor, which in contrast to BaPA stimulates murine IL3-dependent cells, induces the growth of human metachromatically staining cells of an immature morphology with certain resemblance to mast cell-like cells. BaPA inhibits the growth of HL-60 cells, while IL3-like activity stimulates the growth of HL-60 cells. BaPA does not share biochemical similarities to other well-defined human growth factors, while the IL3-like activity has strong resemblance to pluripotential hemopoietic CSF.
D001491:Basophils / Q000502:physiology*; D001854:Bone Marrow Cells; D002460:Cell Line; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D006133:Growth Substances / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007377:Interleukin-3 / Q000494:pharmacology*; D008407:Mast Cells / Q000166:cytology; D008970:Molecular Weight
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D007377:Interleukin-3