Effects of topical treatment with piroxicam on prostaglandin synthesis in experimental uveitis.
We have assessed the efficacy of 0.5% piroxicam collyrium applied for 15 days to the eyes of rabbits in which uveitis had been experimentally induced. The results demonstrate the capability of the drug to easily overcome the ocular barrier. On the 30th day, a clear regression of the uveitis symptoms was observed, the hyperaemia having completely disappeared. By means of radioimmunological assay (RIA), it was found that the increased PGF2 alpha concentration in the aqueous humour had returned to normal levels.
D000287:Administration, Topical; D000818:Animals; D015237:Dinoprost; D008297:Male; D010894:Piroxicam / Q000008:administration & dosage / Q000627:therapeutic use*; D011460:Prostaglandins F / Q000032:analysis / Q000096:biosynthesis*; D011817:Rabbits; D011863:Radioimmunoassay; D014605:Uveitis / Q000188:drug therapy* / Q000378:metabolism
D011460:Prostaglandins F; D010894:Piroxicam; D015237:Dinoprost