Syntheses and biological properties of 8-carbamoylimidazo[1,2-c]pyrimidines and their heterocyclic analogs.
N-substituted 8-carbamoylimidazo[1,2-c]pyrimidines, 9-carbamoylpyrimido[1,2-c]pyrimidines and 8-carbamoyloxazolo[2,3-c]pyrimidines were obtained by the reaction of N-substituted 5-carbamoyl-2-hydroxy-4-mercapto-6-methylpyrimidines with aminoalcohols or ethylene chlorohydrin. Some of the described compounds exhibit weak antiinflammatory and analgetic effects.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006571:Heterocyclic Compounds; D007093:Imidazoles; D011743:Pyrimidines