[Influence of a bovine calf thymic humoral factor on the non-specific cellular immune response of bladder carcinoma patients].
The thymus humoral factor (THF) was extracted from the bovine calf thymus, and its effect on the non-specific cellular immune response of 34 bladder carcinoma patients was studied using the modified micro-whole blood culture method. As a result, in the early stage of bladder carcinoma, the immuno-deficient state of the lymphocytes was restored under the influence of THF, in vitro, but in the terminal stage of bladder carcinoma, the effect of THF was not observed. This difference was clear between the low stage group and high stage group. This fact indicates that the accumulation of precursor T cells occurs in the peripheral blood of the patients of low stage bladder carcinoma, and THF is thought to be effective on T cell maturation. In the late stage of bladder carcinoma, disturbance of the production of immature T cells in the bone marrow is suspected.
D000368:Aged; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D013951:Thymus Hormones / Q000494:pharmacology*; D001749:Urinary Bladder Neoplasms / Q000276:immunology*
D013951:Thymus Hormones; D003208:Concanavalin A; C014859:thymic humoral factor