title: Breast cancer incidence subsequent to surgical reduction of the female breast.
abstract: The incidence of breast cancer was determined in 1245 women who were treated surgically for breast hypertrophy in Copenhagen, Denmark, between 1943 and 1971. Breast cancer cases were identified by a linkage to the Danish Cancer Registry. The expected number of breast cancers was estimated from age and calendar-time specific incidence rates in the Danish female population. A total of 18 breast cancers developed compared to 30.28 expected, yielding a relative risk (RR) of 0.59 (95% confidence interval (CI) 0.35-0.94). The greatest risk reduction was observed ten or more years after the plastic surgery operation in women who had 600 g or more of breast tissue removed (RR = 0.27; 95% CI 0.03-0.99). This suggests that the number of potential foci are important for cancer development in the breast.
mesh_terms: D000328:Adult; D001940:Breast / Q000601:surgery*; D001943:Breast Neoplasms / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D003718:Denmark; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*