Responses of intraepithelial lymphocytes to T-cell mitogens: a comparison between murine and porcine responses.
Intraepithelial lymphocytes (IEL) were isolated from the small intestine of pigs. They showed a strong blastogenic response to the T-cell mitogens phytohaemagglutinin A (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM); in contrast, mouse IEL responded weakly to these mitogens. The response of pig IEL was age-dependent, reaching adult levels by 9 weeks of age. Early weaning of pigs delayed the onset of this response. The effects of inflammatory mediators on the response of mouse IEL were also examined.
D000375:Aging; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007376:Interleukin-2 / Q000276:immunology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D008934:Mitogens / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013552:Swine; D014886:Weaning
D007376:Interleukin-2; D008934:Mitogens; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A; D002927:Cimetidine; D007213:Indomethacin