Reactive lymphocytes in lacrimal gland and vasculitic renal lesions of autoimmune MRL/lpr mice express L3T4.
The lacrimal gland inflammatory lesions and renal vasculitic lesions of autoimmune MRL/lpr mice were analyzed for the lymphocyte subsets present. The majority of cells were Thy-1.2+ T cells (mean, 85%) of the L3T4+ helper T phenotype (mean, 64 and 58%, respectively). Lesser numbers of Lyt-2+ suppressor/cytotoxic T cells, B cells, and macrophages were present. The finding that the majority of lymphocytes in both the lacrimal gland inflammatory lesions and renal vasculitis of MRL/lpr mice expressed L3T4 suggests that these cells may be capable of responding to antigen presentation and that an active immunologic response occurs at these sites.
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology; D007150:Immunohistochemistry; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D007765:Lacrimal Apparatus / Q000166:cytology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014657:Vasculitis / Q000473:pathology*
D000945:Antigens, Differentiation, T-Lymphocyte; D001323:Autoantibodies