[Pathogenesis and therapy of rheumatoid inflammation].
By initial 3H-thymidine labelling an enhanced monocyte proliferation in the bone marrow of patients with rheumatoid arthritis is demonstrated. The significant monocyte proliferation correlates positively with the erythrocyte sedimentation rate but shows a negative correlation with age. The high significance of the mononuclear phagocyte (MNP) system in the pathogenesis of rheumatoid arthritis is seriously underlined by the experimental findings in our allergic arthritis model. Benoxaprofen as an inhibitor of the lipoxygenase pathway and of the inflammatory monocyte influx significantly suppresses the experimental allergic synovitis. These findings stress upon the important role of the MNP-system in the pathogenesis of rheumatoid arthritis and demonstrate the significance of the monocytes/macrophages as an important target-cell system for antirheumatic drugs.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology*; D001345:Autoradiography; D001853:Bone Marrow / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006168:Guinea Pigs; D006801:Humans; D007596:Joints / Q000473:pathology; D007958:Leukocyte Count; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D011422:Propionates / Q000627:therapeutic use; D013583:Synovial Membrane / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000893:Anti-Inflammatory Agents; D011422:Propionates; C011677:benoxaprofen
Pathogenese und Therapie der rheumatischen Entzündung.