Chronic angiotensin treatment stimulates the growth and the 11 beta-hydroxylase activity of rat zona fasciculata cells.
Long-term angiotensin-II (AII) administration provokes a time-dependent rise in the volume of zona fasciculata cells and in the plasma concentration of corticosterone in rats treated with dexamethasone and maintenance doses of ACTH. The AII-induced zona fasciculata cell hypertrophy is coupled with comparable increases in the surface area per cell of the mitochondrial cristae and in the activity per cell of 11 beta-hydroxylase. These findings suggest that AII enhances the growth and the steroidogenic capacity of rat adrenal zona fasciculata.
D000302:Adrenal Cortex / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000097:blood; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013252:Steroid 11-beta-Hydroxylase / Q000378:metabolism*; D013250:Steroid Hydroxylases / Q000378:metabolism*
D000804:Angiotensin II; D013250:Steroid Hydroxylases; D013252:Steroid 11-beta-Hydroxylase; D003345:Corticosterone