[Equilibriometric measurements of central vestibular dysregulation following administration of minocycline].
An equilibriometric study has been performed on 20 healthy young women before and after the intake of 7 times 100 mg minocycline during 3 days. A systematic neurootological equilibriometry was performed analyzing the vestibular ocular, the vestibular spinal, the retino-ocular and the spontaneous nystagmus pathways. The results demonstrate that the tetracycline minocycline provokes a ponto-medullary liberation of the central vestibular regulating mechanisms. The central vestibular disinhibition could be exhibited by the monaurally elicited vestibular ocular nystagmus as well as by the radar image like cranio-corpography recordings of the head and body movements during a vestibular spinal stepping test. In parallel with these findings the participants of the study increasingly complained about vertigo of the rocking type, instability, malaise and wretching. Thus, the untoward side effects of a tetracycline like minocycline which is a frequent complaint of the patients, appears to be due to a central disinhibition of the vestibular equilibrium regulating mechanisms.
D000328:Adult; D004584:Electronystagmography; D005260:Female; D006801:Humans; D008911:Minocycline / Q000009:adverse effects*; D004856:Postural Balance / Q000187:drug effects*; D013754:Tetracyclines / Q000009:adverse effects*; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D013754:Tetracyclines; D008911:Minocycline
Aequilibriometrische Messungen der zentralen Vestibularis-Dysregulation nach Gabe von Minocyclin.