title: Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta.
abstract: A human interleukin 1 beta (IL 1 beta) cDNA probe was utilized to identify a homologous murine cDNA clone. The murine cDNA encodes a 269-residue protein which is 67% homologous to human IL 1 beta. The murine sequence was engineered for expression in mammalian cells and directs the synthesis of biologically active IL 1. This protein, termed murine IL 1 beta, is only 22% homologous with the previously described murine IL 1 sequence. Both IL 1 alpha and IL 1 beta are encoded by single genes, but IL 1 beta mRNA is about fivefold more abundant in a stimulated macrophage cell line.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation; D007375:Interleukin-1 / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D007375:Interleukin-1; D012333:RNA, Messenger; D004247:DNA