Enhancement of host defence by Y-19995 (2,4'-bis(1-methyl-2-dimethyl-aminoethoxyl)-3-benzoylpyridine dimaleate), a novel synthetic compound. II. Activation of phagocytic cell functions.
A novel synthetic compound, Y-19995 potentiated phagocytic activity of rat or mouse peritoneal polymorphonuclear leukocytes in vitro or in vivo, respectively. The agent enhanced NBT reducing capacities of rat and guinea pig polymorphonuclear leukocytes in the peripheral blood ex vivo. Y-19995 restored from phagocytic activity of mouse peritoneal macrophages suppressed by the treatment with prednisolone ex vivo. In addition, IL-1 production by mouse macrophages was augmented by culturing with the agent in vitro. Furthermore, Y-19995 potentiated both phagocytic activity and NBT reducing capacity of human peripheral polymorphonuclear leukocytes in vitro. These results suggested that the activation of phagocytic cell functions by Y-19995 contributed to the enhancement of host defence in immunocompromised hosts.
D000276:Adjuvants, Immunologic; D000818:Animals; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000096:biosynthesis; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D010586:Phagocytes / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats
D000276:Adjuvants, Immunologic; D007375:Interleukin-1; D011725:Pyridines; C054098:Y 19995; D009580:Nitroblue Tetrazolium