[Value of immunological studies in various forms of cardiomyopathy].
Immunologic status of 97 patients with dilating cardiomyopathy (DCMP) and 52 patients with hypertrophic cardiomyopathy (HCMP) was studied; total amount of T-lymphocytes as well as the amount of T-active lymphocytes and B-lymphocytes in the test of E- and EAC-rosette formation, subpopulations of T-lymphocytes (T mu, T g in the EA-rosette formation reaction were determined. HLA-typing in the microlymphocytes toxic test was performed. It was determined that the amount of B- and T-lymphocytes as well as the amount of T mu- and Tg-lymphocytes in patients with HCMP does not practically differ from that in normal subjects. Antigens 27, DR1 and DR4 were proved to be HLA-markers of HCMP. Reliable decrease in the amount of T mu and Tg cells as well as NK cells in patients with DCMP compared to that in normal subjects and patients with HCMP was observed. The study of HLA-antigens distribution in patients with DCMP revealed greater prevalence of DR1 and DR4 antigens.
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D002311:Cardiomyopathy, Dilated / Q000209:etiology / Q000276:immunology*; D002312:Cardiomyopathy, Hypertrophic / Q000209:etiology / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology
D006684:HLA-DR Antigens
Znachenie immunologicheskikh issledovaniĭ pri izuchenii razlichnykh form kardiomiopatii.