[Comparative study of the treatment of simple urinary infection with a single dose of norfloxacin versus cotrimoxazole].
53 women with acute, uncomplicated urinary tract infection proven clinically and bacteriologically were treated, after double-blind randomisation, with a single dose of norfloxacin (1200 mg) or a single dose of cotrimoxazole (480/2400 mg). Follow-up one week after treatment showed a comparable success rate (85%) for both antibiotics. Only few minor side effects were recorded in both patient groups. Most failures were due to gram positive bacteria (coagulase-negative staphylococci). These results suggest that single dose therapy for urinary tract infections due to gram positive germs should be reconsidered.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008875:Middle Aged; D009643:Norfloxacin / Q000627:therapeutic use*; D011897:Random Allocation; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D009643:Norfloxacin
Etude comparative du traitement de l'infection urinaire simple par une dose unique de norfloxacine versus cotrimoxazole.