Is prostaglandin E2 involved in the pathogenesis of fever? Effects of interleukin-1 on the release of prostaglandins.
Interleukin-1 (IL-1) induces the formation of PGE2 from monocytes, fibroblasts, muscle cells, and brain tissue by increasing the intracellular concentrations of CA2+; this cation, in turn, activates a phospholipase which cleaves arachidonic acid from either diacylglycerol or a membrane phospholipid. In addition, IL-1 increases the synthesis of cyclooxygenase, as evidenced by the increased conversion of arachidonic acid into prostaglandins after fibroblasts are pre-incubated with IL-1. Evidence is also presented that fever is caused by interleukin-1-induced prostaglandin E2.
D000818:Animals; D001921:Brain / Q000502:physiology / Q000503:physiopathology; D015232:Dinoprostone; D005334:Fever / Q000503:physiopathology*; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D007249:Inflammation; D007375:Interleukin-1 / Q000502:physiology*; D009000:Monocytes / Q000502:physiology; D009132:Muscles / Q000503:physiopathology; D009474:Neurons / Q000502:physiology; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000502:physiology*; D013217:Starvation
D007375:Interleukin-1; D011453:Prostaglandins; D011458:Prostaglandins E; D015232:Dinoprostone