title: Milestones in anti-inflammatory therapy.
abstract: The anti-inflammatory era opened with aspirin, which for decades was the first-line treatment for rheumatoid arthritis. Striking advances have occurred in recent years with the introduction of propionic acid derivatives like ibuprofen and once-a-day drugs like piroxicam. The class now includes a range of drugs with properties suited to the range of clinical indications presented by rheumatic disorders. Anti-inflammatory drugs are now and will continue to be the mainstay of symptomatic therapy for arthritis.
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D004361:Drug Tolerance; D005544:Forecasting; D006801:Humans; D012216:Rheumatic Diseases / Q000188:drug therapy; D012219:Rheumatology / Q000639:trends*; D013272:Stomach Diseases / Q000139:chemically induced
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal