Effect of dexamethasone on rabbit renal prostaglandin E2 excretion: dependence on urinary flow.
The effects of dexamethasone on urinary PGE2 excretion (UPGE2V) were investigated in rabbits that had free or restricted access to water intake. Dexamethasone, administered by rate-controlled osmotic pumps, enhanced UPGE2V in relation with urinary flow (UV) and sodium excretion (UNaV), from 290.4 +/- 36.5 to 473.4 +/- 49.5 ng/day. Under conditions of water restriction, dexamethasone had no effect on UV and UNaV but reduced UPGE2V from 235.5 +/- 19.1 to 182.6 +/- 10.5 ng/day. It is concluded that: the rise in UPGE4V observed with dexamethasone was secondary to augmented UV or UNaV and urinary PG might not reflect renal synthesis during states of altered urinary flow.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D015232:Dinoprostone; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis; D011458:Prostaglandins E / Q000652:urine*; D011817:Rabbits; D012964:Sodium / Q000378:metabolism
D011453:Prostaglandins; D011458:Prostaglandins E; D003907:Dexamethasone; D012964:Sodium; D015232:Dinoprostone