Glucocorticoid-induced enhancement of IgE synthesis.
Glucocorticoid-induced enhancement of polyclonal immunoglobulin production of the IgG, A, and M classes by human peripheral blood mononuclear cells has been shown to be dependent on regulatory T-cells. The following in vitro investigation demonstrated an enhancing effect of glucocorticoid on IgE production by mononuclear cells from atopic patients, but not by cells from non-atopic subjects. Augmentation was noted even in cell populations depleted of T cells and monocytes. These observations suggest that the corticosteroid acted directly on an IgE B cell at a late stage of differentiation that was no longer dependent on helper T-cells, although an additional effect on T-suppressor cells was not excluded.
D001402:B-Lymphocytes / Q000276:immunology; D003907:Dexamethasone / Q000494:pharmacology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis*; D066298:In Vitro Techniques; D009000:Monocytes / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D007073:Immunoglobulin E; D003907:Dexamethasone