Role of glandular kallikreins as growth factor processing enzymes: structural and evolutionary considerations.
Hormones and growth factors are generally released from larger precursors by limited proteolysis. The causative agents remain poorly defined with respect to location and properties. One subset of proteases, the glandular kallikreins, have been implicated in a few cases, in part because of their specific association with mature forms of some hormones. However, limited distribution and low copy number in some species cast doubt on this hypothesis, and they may well play other physiological functions that remain to be elucidated.
D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D002352:Carrier Proteins; D004815:Epidermal Growth Factor / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism*; D007610:Kallikreins / Q000502:physiology*; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D009414:Nerve Growth Factors / Q000378:metabolism; D011467:Prostate / Q000201:enzymology; D011499:Protein Processing, Post-Translational; D012469:Salivary Glands / Q000201:enzymology; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D014357:Trypsin
D002352:Carrier Proteins; D006133:Growth Substances; D046911:Macromolecular Substances; D009414:Nerve Growth Factors; D004815:Epidermal Growth Factor; D007610:Kallikreins; D014357:Trypsin