Induction of early-phase endotoxin tolerance in athymic (nude) mice, B-cell-deficient (xid) mice, and splenectomized mice.
Early-phase endotoxin tolerance was inducible in mice which were T cell deficient (nude), B cell deficient (xid), or asplenic, which suggests that these lymphoid cell subsets and the spleen do not contribute significantly to the induction of acquired lipopolysaccharide hyporesponsiveness. C3H/HeJ mice did not exhibit the hematopoietic changes observed in mice made endotoxin tolerant, which suggests that multiple mechanisms may underlie lipopolysaccharide hyporesponsiveness.
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D003115:Colony-Stimulating Factors / Q000096:biosynthesis; D004731:Endotoxins / Q000633:toxicity*; D005260:Female; D006412:Hematopoietic Stem Cells; D008070:Lipopolysaccharides / Q000633:toxicity; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D008819:Mice, Nude; D013156:Splenectomy
D003115:Colony-Stimulating Factors; D004731:Endotoxins; D008070:Lipopolysaccharides