Generation in vitro of alloreactive lymphocytes is suppressed by the addition of spleen cells from mice infected with lymphocytic choriomeningitis virus.
The generation of cytotoxic T cells to alloantigens in mixed lymphocyte culture was suppressed by the addition of spleen cells from adult mice acutely infected with lymphocytic choriomeningitis virus. T cells of surface phenotype Lyt 1+2+ were required for the suppression. Suppressive cells appeared also in lymph nodes, but not in the thymus. In the spleen their number was maximal 6 to 8 days after infection. Infectious virus could not be detected in the suppressive spleen cells. Therefore the virus itself does not seem to cause the effect.
D000818:Animals; D005260:Female; D007165:Immunosuppression Therapy; D066298:In Vitro Techniques; D007700:Kinetics; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013154:Spleen / Q000276:immunology* / Q000382:microbiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*