title: Detection of gastroduodenal ulcers using technetium-99m-labeled sucralfate.
abstract: Sucralfate is an effective medication for treatment of gastroduodenal ulcers, and 99mTc-labeled sucralfate has been found to adhere to ulcers. In this study, we examined the reliability of confirming the diagnosis of gastroduodenal ulcers--previously detected by endoscopy and histology--by means of sucralfate labeled with 99mTc, imaging 1 and 2 hr after oral administration. Eighteen out of 23 patients were positive by scintigraphy with this method (sensitivity = 78%). In five patients with gastroduodenal bleeding, the study was positive. The procedure was well tolerated and offered a noninvasive procedure that can be performed at the bedside in critically ill patients, and in follow-up of fragile patients.
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004381:Duodenal Ulcer / Q000000981:diagnostic imaging*; D004384:Duodenoscopy; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000000981:diagnostic imaging; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D011859:Radiography; D011877:Radionuclide Imaging; D013276:Stomach Ulcer / Q000000981:diagnostic imaging*; D013392:Sucralfate; D013667:Technetium
chemical_list: D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; C038248:technetium Tc 99m sucralfate; D013392:Sucralfate; D013667:Technetium