[Effect of phospholipids of different compositions on coronary vessel tonus and myocardial contractility].
In experiments on perfused isolated Wistar rat hearts and frog myocardial strips it has been shown that the injection of egg phospholipid liposomes in the perfusion solution leads to a decrease in the volume velocity of the coronary perfusion and to worsening of the contractile myocardial function. Negative inotropic effect of phospholipids on the perfused heart may be linked not only with the decrease in the coronary perfusion but also with their direct inhibitory action on the contractile ability of myocardiocytes.
D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D010713:Phosphatidylcholines / Q000494:pharmacology; D010714:Phosphatidylethanolamines / Q000494:pharmacology; D010743:Phospholipids / Q000494:pharmacology*; D011896:Rana temporaria; D051381:Rats
D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids
Vliianie fosfolidipidov razlichnogo sostava na tonus koronarnykh sosudov i sokratitel'nuiu sposobnost' miokarda.