Type IX collagen is a potent inducer of PGE2 and interleukin 1 production by human monocyte macrophages.
Type IX collagen and its collagenous fragments are potent stimulatory agents on human blood mononuclear cells for the production of prostaglandin E2 and interleukin 1/mononuclear cell factor. Type IX collagen is 2-4-fold more potent that type I and II and 1 alpha-, 2 alpha- and 3 alpha-collagens. This property may be important in the destructive process of cartilage in inflammatory diseases.
D002478:Cells, Cultured; D003094:Collagen / Q000494:pharmacology*; D015232:Dinoprostone; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D008264:Macrophages / Q000378:metabolism*; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D015846:Monokines; D011458:Prostaglandins E / Q000096:biosynthesis*; D014176:Protein Biosynthesis
D007375:Interleukin-1; D015846:Monokines; D011458:Prostaglandins E; D003094:Collagen; D015232:Dinoprostone