[Trans-1-(4-phenylcyclohexyl)ethylamine derivatives with antidepressant activity. II].
Some derivatives of trans-1-(4-phenylcyclohexyl)ethylamine (A) with a substituent at position 4 of the phenyl group were prepared and tested for antireserpine activity on the CNS. All compounds showed reduced activity compared with that of (A) except the amino derivative (II) which proved more active but at the same time showed increased toxicity and other adverse effects on the CNS.
D006916:5-Hydroxytryptophan / Q000378:metabolism; D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D003510:Cyclohexanes / Q000138:chemical synthesis* / Q000494:pharmacology; D004435:Eating / Q000187:drug effects; D005021:Ethylamines / Q000138:chemical synthesis* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors
D000928:Antidepressive Agents; D003510:Cyclohexanes; D005021:Ethylamines; D012110:Reserpine; D006916:5-Hydroxytryptophan
Derivati della trans-1-(4-fenilcicloesil)etilammina ad attivita' antidepressiva--Nota II.