title: Catecholaminergic innervation of neurons containing corticotropin-releasing factor in the paraventricular nucleus of the rat hypothalamus.
abstract: Catecholaminergic synaptic input to neurons containing corticotropin-releasing factor (CRF) in the parvocellular portion of the paraventricular nucleus (PVN) in the rat hypothalamus was observed. The experimental techniques used combine autoradiography after 3H-noradrenaline (3H-NA) injection or uptake of 5-hydroxydopamine (5-OHDA) with immunocytochemistry using CRF antiserum. CRF-like immunoreactive cell bodies and fibers in the PVN received synaptic inputs from the axon terminals in which a selective accumulation of 3H-NA or 5-OHDA was found. This finding suggests that the secretion of CRF neurons may be regulated via synapses by catecholaminergic neurons.
mesh_terms: D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000032:analysis*; D006892:Hydroxydopamines; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000032:analysis* / Q000648:ultrastructure; D009638:Norepinephrine; D010286:Paraventricular Hypothalamic Nucleus / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006892:Hydroxydopamines; C027802:5-hydroxydopamine; D003346:Corticotropin-Releasing Hormone; D009638:Norepinephrine