Tubocurarine chloride inhibits rod outer segment shedding in the frog retina.
The cholinergic postsynaptic neuromuscular blocker, tubocurarine chloride (curare), attenuates the rod shedding response of the frog in a dose-dependent manner. Injections of curare into the dorsal lymph sacs or intraocularly into the vitreous of the eye produced similar results. Intraocular injections of Ringer solution of varying quantities of 0.9% NaCl (the carrier solution of the commercially prepared curare), had no adverse effect on the shedding response. Additionally, injections of curare into one eye had no effect on the rod shedding rate of the other eye.
D000818:Animals; D003472:Curare / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005123:Eye; D007267:Injections; D008208:Lymphatic System; D010786:Photoreceptor Cells / Q000187:drug effects*; D011894:Rana pipiens; D012374:Rod Cell Outer Segment / Q000187:drug effects*
D003472:Curare