Aberration of monokine production and monocyte subset in patients with systemic lupus erythematosus.
We measured the production of interleukin 1 (IL-1) and prostaglandin by adherent cells from patients with systemic lupus erythematosus (SLE). Compared to normal subjects, IL-1 production in the patients was lower but prostaglandin E1 production was higher. Furthermore, examination of monocyte subsets in patients with SLE using monoclonal anti-monocyte/granulocyte antibodies disclosed abnormal expression of membrane antigens on monocytes. It is speculated that aberration of monocyte function is related to impaired monokine production and that membrane antigens play a role in immunodysregulation in patients with SLE.
D006801:Humans; D007166:Immunosuppressive Agents; D007375:Interleukin-1 / Q000096:biosynthesis; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*; D009000:Monocytes / Q000145:classification* / Q000502:physiology; D015846:Monokines; D011453:Prostaglandins / Q000096:biosynthesis / Q000097:blood; D014176:Protein Biosynthesis; D012016:Reference Values
D007166:Immunosuppressive Agents; D007375:Interleukin-1; D015846:Monokines; D011453:Prostaglandins