[Prognosis of the degree of exposure of amino acid residues in globular proteins in relation to various problems of protein engineering].
The algorithm was developed to predict the degree of exposure of amino acid residues in globular proteins. This algorithm combined with standard discriminant analysis methods was used for evaluation of the accessibility of Lys and Arg residues for trypsin-like proteases attack. The procedure can be useful for a computer-aided design of prolonged-action protein drug preparations.
D000596:Amino Acids; D005818:Genetic Engineering; D007375:Interleukin-1 / Q000235:genetics; D009113:Muramidase / Q000235:genetics; D011379:Prognosis; D011506:Proteins
D000596:Amino Acids; D007375:Interleukin-1; D011506:Proteins; D009113:Muramidase
Prognozirovanie éksponirovannosti aminokislotnykh ostatkov v globuliarnykh belkakh v sviazi s nekotorymi zadachami belkovoĭ inzhenerii.