title: Sex reversal in wrasses. I. Uptake of testosterone by the gonads and the central nervous system and its aromatization in the CNS of Thalassoma duperrey (Teleostei: Labridae).
abstract: 3H-Labelled testosterone, injected into the peritoneal cavity of T. duperrey is taken up by the central nervous system and the gonads. In the brain maximal uptake occurs within 1 to 2 h whereas maximal uptake in the gonads takes place within 1/2 to 1 h. Relatively large amount of radioactivity were eliminated into water: the elimination reached 8% of the injected dose in 4 h. The brain and the gonads are capable of aromatizing injected androgen, forming estrone, estradiol and more polar metabolites (i.e. containing more than 2 hydroxyl groups) and water soluble derivatives (possibly either the sulfates, or glucuronides). The uptake, and metabolism, may be higher in males as compared to females.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D005260:Female; D005399:Fishes / Q000378:metabolism*; D006066:Gonads / Q000378:metabolism; D057850:Hermaphroditic Organisms; D008297:Male; D019849:Sex Determination Processes; D013739:Testosterone / Q000378:metabolism*
chemical_list: D013739:Testosterone