Differentiation of the organic matrix in bone repair.
This study describes the sequence of production and distribution of collagen, collagen types, proteoglycans, and calcium during bone repair in rabbits utilizing histologic and biochemical techniques. Proteoglycan content peaked 11 days following surgery and total collagen peaked 19 days after surgery, after which both levels decreased. Collagen Types I and III were present in the bone defect throughout the healing process but Type II was found only in the mid stages of repair. In the surrounding external callus Types I, II, and III were present, but Type III was not noted in the later stages of healing. These results are similar to those found in studies of fracture repair and developing bone.
D000818:Animals; D001777:Blood Coagulation; D001857:Bone Matrix / Q000033:anatomy & histology / Q000378:metabolism*; D002146:Bony Callus / Q000033:anatomy & histology; D002113:Calcification, Physiologic; D002118:Calcium / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism*; D005260:Female; D005944:Glucosamine / Q000378:metabolism; D006097:Granulation Tissue / Q000033:anatomy & histology; D011509:Proteoglycans / Q000378:metabolism*; D011817:Rabbits; D013977:Tibia; D014945:Wound Healing
D011509:Proteoglycans; D003094:Collagen; D005944:Glucosamine; D002118:Calcium