Concentration of pefloxacine in split ejaculates of patients with chronic male accessory gland infection.
The concentrations of pefloxacine and its N-demethylated derivative were measured in split ejaculates of 12 patients with chronic male accessory gland infection during treatment with 400 mg. pefloxacine twice a day. The mean concentrations of pefloxacine and N-demethylated pefloxacine (mg. per l.) were 8.7 +/- 1.2 (standard error of the mean) and 4.2 +/- 0.7 in fraction 1, and 9.8 +/- 1.1 and 4.3 +/- 0.6 in fraction 2. The concentrations in both fractions were correlated strongly (r equals 0.97). The concentration of pefloxacine in the secretory fluids of the prostate and seminal vesicles are 30-fold the minimal inhibitory concentration 90 of Escherichia coli and Klebsiella species, 100-fold the minimal inhibitory concentration 90 of Proteus mirabilis and equal to the minimal inhibitory concentration 90 of Streptococcus faecalis. In three-fourths of the patients signs of infection resolved after 4 weeks of treatment.
D000328:Adult; D002908:Chronic Disease; D005088:Exocrine Glands; D005832:Genital Diseases, Male / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007248:Infertility, Male / Q000209:etiology*; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism / Q000627:therapeutic use; D015366:Pefloxacin; D012661:Semen / Q000032:analysis*
D015366:Pefloxacin; D009643:Norfloxacin