Changes in intracellular pH and cell volume during the early phase of DMSO-induced differentiation of Friend erythroleukemia cells.
Changes in intracellular pH and water volume were measured after treatment of Friend erythroleukemia cells with 1.5% DMSO. It was found that a continuous decrease in pHi occurred, beginning 1 h after induction and a decline in pHi of 0.18 was measured after 9 h. In addition a decline in cellular water volume, of 12% only 15 min after induction, and 23% after 9 h, was observed.
D000818:Animals; D002454:Cell Differentiation; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D005622:Friend murine leukemia virus; D006863:Hydrogen-Ion Concentration; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology*; D051379:Mice
D004121:Dimethyl Sulfoxide