title: [Intrathecal methotrexate--overdosing in pediatric lymphoblastic leukemia].
abstract: Intrathecal methotrexate-overdosage in the meningosis therapy leads to CNS damages dependent on dose. It was given a own case report and a literature review with clinical symptoms and the therapy in this complication. Neuropathologic findings included demyelinisation und necrosis of the white matter.
mesh_terms: D001927:Brain Diseases / Q000139:chemically induced; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007278:Injections, Spinal; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D008727:Methotrexate
vernacular_title: Intrathekale Methotrexat--Uberdosierung bei kindlicher lymphoblastischer Leukose.