Post-transplantation T cell lymphoblastic lymphoma.
Immunosuppressed renal transplant recipients are at increased risk for large cell lymphoma of B cell phenotype. This report describes a case of post-transplantation lymphoma presenting with a mediastinal mass causing superior vena cava syndrome, tracheal obstruction, and pleural effusion. Cytospin preparations of pleural fluid documented high-grade lymphoblastic lymphoma morphology and immature T cell (cortical thymocyte) phenotype: Leu 1-6-positive, Leu 9-positive, Tdt-positive, B-negative, Calla-positive. The occurrence of post-transplantation lymphoma of T cell lineage is inconsistent with the postulated Epstein-Barr virus origin and raises important questions regarding the development of lymphoproliferative disorders in immunosuppressed organ transplant recipients.
D000328:Adult; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology*; D008297:Male; D013601:T-Lymphocytes; D014181:Transplantation Immunology