Delayed type hypersensitivity responses to the Qa-Tla region of the mouse major histocompatibility complex.
We have elicited a small but significant delayed-type hypersensitivity response against the Qa-Tla region of H-2 following immunisation of C57BL/6 mice with cells from the congenic strain C57BL/6.Tlaa. Optimal responses were detected 14 days after immunisation with 10-40 X 10(6) cells. The significance of delayed type hypersensitivity to Qa-Tla is discussed in relation to the genetic loci which map to this region.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology*; D003520:Cyclophosphamide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D005260:Female; D015395:Histocompatibility Antigens Class I; D006968:Hypersensitivity, Delayed / Q000235:genetics / Q000276:immunology*; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000276:immunology; D008810:Mice, Inbred C57BL / Q000235:genetics / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology
D000954:Antigens, Surface; D015395:Histocompatibility Antigens Class I; C032907:Q surface antigens; C040588:Tla antigens; D003609:Dactinomycin; D003520:Cyclophosphamide