The capillary thrombometer revisited.
A modified capillary thrombometer was constructed to study the rate of thrombus formation using heparinized whole blood (2 U/ml) obtained from normal adults (n = 22) and children (n = 20) and patients with hemophilia A (n = 10) or von Willebrand's disease (n = 8). The median thrombosis times were as follows: normal adults = 12.8 min (range = 4.5-26.0), normal children = 13.3 min (range = 5.7-29.0), patients with hemophilia A = 37.2 min (range = 20.0-60.0 min), and patients with von Willebrand's disease = 60.0 min (range = 37.2-60.0). Significant differences were demonstrated between all groups of subjects, except between normal adults and children. The capillary thrombometer appears to measure thrombus formation dependent on adequate Willebrand factor and platelets.
D000293:Adolescent; D000328:Adult; D001780:Blood Coagulation Tests / Q000295:instrumentation*; D002648:Child; D004867:Equipment Design; D005260:Female; D006467:Hemophilia A / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D013223:Statistics as Topic; D014914:Whole Blood Coagulation Time; D014842:von Willebrand Diseases / Q000097:blood