[Rearrangement of the receptor genes of T cells for an antigen].
In this review, after a short description of the T-cell receptor alpha and beta gene organization, the results obtained by rearrangement analysis in human lymphoid proliferations are analysed. Southern analysis appear to be a useful tool for the study of clonality and at a less degree, of lineage involvement in such neoplasias. The significance of rearrangement of T-cell receptor genes in B-lineage proliferations is also discussed.
D002454:Cell Differentiation; D002455:Cell Division; D002874:Chromosome Mapping; D005786:Gene Expression Regulation; D005819:Genetic Markers; D006801:Humans; D011947:Receptors, Antigen, B-Cell / Q000235:genetics*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013601:T-Lymphocytes / Q000166:cytology / Q000648:ultrastructure*
D005819:Genetic Markers; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell
Réarrangement des gènes du récepteur des cellules T pour l'antigène.