Promyelocytic blast crisis of Philadelphia-positive thrombocythemia with translocations (9;22) and (15;17).
We report a promyelocytic blast crisis in a case of Ph-positive thrombocythemia with both t(9;22) and t(15;17). Our patient confirms the specificity of t(15;17) in malignant proliferation of promyelocytes and suggests its appearance as a second genetic event in the genesis of blast crisis occurring in a Ph-positive clone.
D000368:Aged; D000369:Aged, 80 and over; D001752:Blast Crisis / Q000235:genetics*; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D010677:Philadelphia Chromosome; D013920:Thrombocythemia, Essential / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic
D005819:Genetic Markers