[Does alpha-tocopherol interact with the active center of cytochrome P-450 in liver microsomes?].
The interaction of alpha-tocopherol (alpha-T) and its synthetic derivative 2,2,5,7,8-pentamethyl-6-hydroxy-chroman (PMC) with cytochrome P-450 system was studied in the rat liver microsomes. Spectral differentiations of type I, increase of NADPH oxidation rate and inhibition of 7-ethoxycoumarin deethylase in microsomes were observed only in the presence of PMC. The results obtained suggest that unlike alpha-T, PMC is effectively bound and metabolized by cytochrome P-450.
D015660:7-Alkoxycoumarin O-Dealkylase; D000818:Animals; D001665:Binding Sites; D001711:Biotransformation; D002384:Catalysis; D002839:Chromans / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004347:Drug Interactions; D007700:Kinetics; D008862:Microsomes, Liver / Q000201:enzymology*; D009243:NAD / Q000378:metabolism; D010105:Oxygenases / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D014810:Vitamin E / Q000378:metabolism*
D002839:Chromans; D009243:NAD; D014810:Vitamin E; D003577:Cytochrome P-450 Enzyme System; C029141:2,2,5,7,8-pentamethyl-1-hydroxychroman; D010105:Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase
Vzaimodeĭstvuet li al'fa-tokoferol s aktivnym tsentrom tsitokhroma P-450 v mikrosomakh pecheni?