[Effect of microbial sensitization and delayed-type hypersensitivity reaction on interleukin-1 production and the generation of monocyte and natural killer cytotoxicity].
Injection of tuberculin PPD or BCG vaccine to tuberculin-positive (Tb+) healthy persons resulted in delayed-type hypersensitivity (DTH) reaction, and obvious monocyte and large granular lymphocyte (LGL) cytotoxicity activation, while the injection of the preparations to tuberculin-negative (Tb-) donors failed to influence the effector activity. Monocytes and LGL produced higher levels of interleukin-I (IL-I) in Tb+ than in Tb- persons. Blockade of Ia-structures with monoclonal antibodies or UV-radiation eliminated the stimulating effect of DTH reaction on monocyte and LGL cytotoxicity and IL-I production. The interaction with monocytes, possessing unaffected Ia-structures, is necessary for LGL activation in Tb+ persons treated with PPD.
D000328:Adult; D001500:BCG Vaccine / Q000008:administration & dosage; D003602:Cytotoxicity, Immunologic; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007114:Immunization; D007375:Interleukin-1 / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D014374:Tuberculin Test
D001500:BCG Vaccine; D000949:Histocompatibility Antigens Class II; D007375:Interleukin-1
Vliianie mikrobnoĭ sensibilizatsii i reaktsii giperchuvstvitel'nosti zamedlennogo tipa na produktsiiu interleĭkina-1 i generatsiiu tsitotoksichnosti monotsitov i estestvennykh killerov.