Release of interleukin-1 by peripheral blood mononuclear cells in patients with tuberculosis and active inflammation.
Peripheral blood monocytes from patients with active tuberculosis and acute inflammatory disease showed spontaneous interleukin-1 production when compared with those from control patients or healthy controls. Moreover, interleukin-1 production appeared to be a more specific indicator of active disease than were other commonly used indices, such as the erythrocyte sedimentation rate and serum C-reactive protein levels.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007375:Interleukin-1 / Q000378:metabolism*; D007376:Interleukin-2 / Q000096:biosynthesis; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D014376:Tuberculosis / Q000378:metabolism*
D007375:Interleukin-1; D007376:Interleukin-2; D002097:C-Reactive Protein