title: Effectiveness of scalp cooling in reducing alopecia caused by epirubicin treatment of advanced breast cancer.
abstract: The value of scalp cooling in the prevention of alopecia was investigated in 32 patients with advanced breast cancer who were given a mean of four courses of 40-80 mg/m2 of epirubicin. None of the 15 patients free from liver metastases who received scalp cooling required a wig, whereas four of eight similar patients who did not receive scalp cooling did require a wig. Abnormalities of aspartate transaminase and alkaline phosphatase pretreatment were predictive for reduced efficacy of scalp cooling, but not a contraindication to its use.
mesh_terms: D000505:Alopecia / Q000517:prevention & control*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D015251:Epirubicin; D005260:Female; D007036:Hypothermia, Induced; D008113:Liver Neoplasms / Q000556:secondary
chemical_list: D015251:Epirubicin; D004317:Doxorubicin