Effect of imipenem (N-formimidoyl-thienamycin) on the in-vitro lymphocyte proliferation.
Imipenem, a new carbapenem, was tested for its inhibitory or stimulatory effects on concanavalin A- and phytohaemagglutinin-stimulated and unstimulated proliferation (measured by 3H-thymidine uptake) of murine splenocytes and thymocytes. Addition of imipenem at concentrations of 10-50 mg/l induced lymphocyte transformation in unstimulated and mitogen-stimulated lymphocytes. Since imipenem stimulated blastogenesis at concentrations achievable in serum when used therapeutically, these results may have potential clinical significance.
D000818:Animals; D003208:Concanavalin A; D015378:Imipenem; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008809:Mice, Inbred C3H; D013154:Spleen / Q000187:drug effects; D013845:Thienamycins / Q000494:pharmacology*; D013950:Thymus Gland / Q000187:drug effects
D013845:Thienamycins; D003208:Concanavalin A; D015378:Imipenem