Influence of tumour carriage on the production of lymphokines affecting macrophage behaviour.
Normal and cyclophosphamide (Cy)-enhanced delayed-type hypersensitivity (DTH) reactions to sheep red blood cells (SRBC) were severely impaired in CD1 mice injected with 10(6) viable Landschütz ascites carcinoma (LAC) cells at the time of immunization. The tumour-induced suppression of DTH was accompanied by inhibition of splenic T-lymphocyte responses to antigen and mitogen. This was assessed by measuring lymphocyte transformation and the production of two lymphokines affecting macrophage behavior, i.e. lymphocyte-derived chemotactic factor (LDCF) and macrophage procoagulant-inducing factor (MPIF). Our results imply that impaired production/function of lymphokines affecting macrophage behaviour may play a key role in tumour-induced suppression of cell-mediated immunity and that this inhibition is independent of Cy-sensitive suppressor cells.
D000818:Animals; D001779:Blood Coagulation Factors / Q000096:biosynthesis; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology*; D002460:Cell Line; D019744:Chemokines, C; D005260:Female; D006968:Hypersensitivity, Delayed; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000096:biosynthesis*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D012795:Sialoglycoproteins / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000276:immunology
D001779:Blood Coagulation Factors; D019744:Chemokines, C; D008222:Lymphokines; D012795:Sialoglycoproteins; C486249:Xcl1 protein, mouse; C018997:lymphotactin; C045072:macrophage procoagulant activity