title: HLA DR4 and B27 antigens in familial and sporadic rheumatoid arthritis.
abstract: We studied HLA antigens in 105 unrelated American Caucasian patients with rheumatoid arthritis (RA), 70 of them with familial disease. HLA-DR4 was observed in 71% of familial RA, 63% of non-familial RA, and 27% of normal controls, confirming the already well-established association between HLA-DR4 and both familial and non-familial RA. HLA-B27 was present in 14.3% of patients, versus 8% of normal controls (p = 0.04), and was not more common in familial (10 of 70, or 14.3%) versus non-familial (5 of 35, or 14.3%) disease. These results are compared with those observed in Scandinavian patients.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics*; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen; D006681:HLA-D Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D015804:HLA-DR4 Antigen; D006239:Haplotypes; D006801:Humans; D012537:Scandinavian and Nordic Countries; D014481:United States
chemical_list: D006680:HLA Antigens; D015796:HLA-B27 Antigen; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen