title: [Electron microscopic detection of the proteoglycan component of the extracellular matrix in osteogenic sarcomas].
abstract: Electron-microscopic studies in which Alcian blue was used to demonstrate proteoglycans (PG) revealed a predominance of largely undifferentiated tumor cells in two of the osteosarcomas examined; the extracellular matrix of these tumors had few PG-containing structures. Other osteosarcomas, where cells of the osteoblastic type prevailed, were found to possess PG granules on the cell surface and a rough PG network in the pericellular space. In a parosteal osteosarcoma, which contained strongly elongated fibroblast-like cells, PG formed a fine mesh both in the pericellular space and throughout the extracellular matrix. A correlation therefore exists between the ultrastructure of the PG component in the extracellular matrix of osteogenic sarcomas and the degree and direction of tumor cell differentiation.
mesh_terms: D000423:Alcian Blue; D000818:Animals; D001859:Bone Neoplasms / Q000648:ultrastructure* / Q000662:veterinary; D004283:Dog Diseases / Q000473:pathology; D004285:Dogs; D005109:Extracellular Matrix / Q000648:ultrastructure*; D008854:Microscopy, Electron; D012516:Osteosarcoma / Q000648:ultrastructure* / Q000662:veterinary; D011509:Proteoglycans / Q000032:analysis*
chemical_list: D011509:Proteoglycans; D000423:Alcian Blue
vernacular_title: Elektronno-mikroskopicheskoe vyiavlenie proteoglikanovogo komponenta vnekletochnogo matriksa osteogennykh sarkom.