Spontaneous wasting disease in nude mice associated with Pneumocystis carinii infection.
Several cases of wasting disease and dyspnea occurred in outbred Crl: CDI(ICR) nu/nu mice obtained recently from a commercial supplier. Gross necropsy revealed pulmonary consolidation, and histologically there was alveolar-wall thickening and filling of alveoli with macrophages and honey-combed eosinophilic material. Electron microscopic examination of lung tissue confirmed infection with Pneumocystis carinii.
D000818:Animals; D004417:Dyspnea / Q000209:etiology; D008168:Lung / Q000473:pathology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011010:Pneumocystis / Q000648:ultrastructure; D011020:Pneumonia, Pneumocystis / Q000209:etiology* / Q000469:parasitology / Q000473:pathology