[The effect of drugs on the immune response].
In this study the effects of some drugs on the humoral and cellular immune responses were carried out. On the studying of laboratory animals, the humoral response by the antibody formation against S.typhi and the cellular response by PPD tuberculin of vaccinated animals with BCG, were examined. According to the experimental results, it was observed that Trimethoprim/Sulfamethoxazole (Baktrim) and Chloramphenicol did not effect humoral response but inhibited cellular response. It was determined that Rifampin had any effect on the humoral and cellular responses. On the other hand it was observed that Cimetidine inhibited the humoral response and increased the cellular response.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001500:BCG Vaccine / Q000276:immunology; D002701:Chloramphenicol / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D004338:Drug Combinations / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects*; D011817:Rabbits; D012293:Rifampin / Q000494:pharmacology; D012485:Salmonella typhi / Q000276:immunology; D013420:Sulfamethoxazole / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014374:Tuberculin Test
D001500:BCG Vaccine; D004338:Drug Combinations; D002701:Chloramphenicol; D002927:Cimetidine; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D012293:Rifampin
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