Multiple congenital anomalies associated with apparently normal maternal intake of vitamin A: a phenocopy of the isotretinoin syndrome?
The teratogenicity of vitamin A has been repeatedly reported in the literature and confirmed on the basis of several cases of adverse pregnancy outcome associated with maternal isotretinoin exposure. We report a case which shows a striking similarity with this syndrome, but the child was born to a mother who took a normal supplementation of vitamin A during pregnancy. The differential diagnosis is discussed.
D000014:Abnormalities, Drug-Induced / Q000175:diagnosis / Q000209:etiology*; D000015:Abnormalities, Multiple / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology*; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015474:Isotretinoin; D010641:Phenotype; D011247:Pregnancy; D014212:Tretinoin / Q000009:adverse effects; D014801:Vitamin A / Q000008:administration & dosage / Q000009:adverse effects; D014815:Vitamins / Q000008:administration & dosage / Q000009:adverse effects*
D014815:Vitamins; D014801:Vitamin A; D014212:Tretinoin; D015474:Isotretinoin