[Muscle dipeptides--natural inhibitors of lipid peroxidation].
The effects of carnosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-1-methyl-L-histidine) on ascorbate-dependent lipid peroxidation in frog skeletal muscle sarcoplasmic reticulum were studied. It was found that the dipeptides (10-50 mM) cause a 25-90% inhibition of ascorbate-dependent lipid peroxidation and decrease the reaction rate and the amount of end products. The nature of lipid peroxidation primary products in the presence of the dipeptides changes which can be evidenced from changes in their spectral properties. Unlike other known natural antioxidants, skeletal muscle dipeptides do not only inhibit lipid peroxidation but also decrease the level of accumulated lipid peroxidation products. Histidine and beta-alanine, similar to imidazole, glycyl-glycine, arginyl-phenyl alanine and alpha-alanyl-D-histidine do not inhibit lipid peroxidation. At the same time, the carnosine stereoisomer D-carnosine which does not exist in nature exhibits a far greater inhibiting effect as compared to its natural counterpart. It is assumed that the skeletal muscle dipeptides carnosine and anserine are highly effective as natural antioxidants.
D000818:Animals; D000861:Anserine / Q000494:pharmacology*; D002336:Carnosine / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D009124:Muscle Proteins / Q000502:physiology; D011896:Rana temporaria; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*
D004151:Dipeptides; D008054:Lipid Peroxides; D008563:Membrane Lipids; D009124:Muscle Proteins; D008315:Malondialdehyde; D002336:Carnosine; D000861:Anserine
Myshechnye dipeptidy--prirodnye ingibitory perekisnogo okisleniia lipidov.