Thymus grafts induce B cell development in nude, X-linked immune deficient mice.
Mice simultaneously expressing the mutations nude and X-linked immune deficiency (xid) were previously shown to have pro-B cells and/or early pre-B cells while lacking C mu+ and surface Ig+ cells. We now report that thymus grafts restore both T cells and B cells in nude-xid mice. By the use of Thy-1 and Igh allogeneic donors it was shown that both the T and B cells were host derived. The B cells had a functional phenotype typical of xid mice. It is concluded that the maturation of xid B cells past the pro-B or early pre-B stage is T cell dependent.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D007126:Immunoglobulin Allotypes / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008211:Lymphocyte Cooperation; D051379:Mice; D008806:Mice, Inbred AKR; D008808:Mice, Inbred CBA; D008817:Mice, Mutant Strains / Q000235:genetics / Q000276:immunology*; D008819:Mice, Nude / Q000235:genetics / Q000276:immunology*; D008934:Mitogens / Q000494:pharmacology; D013950:Thymus Gland / Q000502:physiology / Q000637:transplantation*; D014960:X Chromosome
D000941:Antigens; D007126:Immunoglobulin Allotypes; D008934:Mitogens