Synovial membrane-cartilage interactions--the role of serine proteinase inhibitors in interleukin-1 mediated degradation of articular damage.
Using a peritoneal macrophage/articular cartilage co-culture system, it was shown that the serine proteinase inhibitor derived from human articular cartilage modulated the release of 35S-labelled proteoglycan into media in a concentration dependent manner. Since the cartilage inhibitor fractions used were free of metallo-proteinase and cysteine proteinase inhibitory activity, but strongly inhibited serine proteinases, it was suggested that such enzymes may be implicated in the activation of latent metallo-proteoglycanases produced by chondrocytes on exposure to IL-1.
D000818:Animals; D002358:Cartilage, Articular / Q000378:metabolism*; D046508:Culture Techniques; D007375:Interleukin-1 / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism; D011480:Protease Inhibitors / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D011509:Proteoglycans / Q000378:metabolism; D011817:Rabbits; D015842:Serine Proteinase Inhibitors; D013583:Synovial Membrane / Q000378:metabolism*
D007375:Interleukin-1; D011480:Protease Inhibitors; D011506:Proteins; D011509:Proteoglycans; D015842:Serine Proteinase Inhibitors