Reduced urinary epidermal growth factor levels in Snell dwarf mutant mice.
Because of findings implicating thyroid and growth hormones in the regulation of urinary EGF concentration, we determined urine and kidney EGF concentrations and relative kidney weights in both sexes of 8 weeks old dwarf mutant mice of the Snell strain and their normal littermates. Both male and female dwarfs had subnormal urine and kidney EGF concentrations. A female greater than male sex difference in both concentrations was present in the normal mice, but not in the dwarfs. The male greater than female sex difference in relative kidney weight, which has been demonstrated in normal mice of the Swiss-Webster strain, was not present in the normal or dwarf Snell mice.
D000375:Aging; D000818:Animals; D001835:Body Weight; D004815:Epidermal Growth Factor / Q000652:urine*; D005260:Female; D007668:Kidney / Q000378:metabolism; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D009929:Organ Size; D012737:Sex Factors
D004815:Epidermal Growth Factor