Cognitive and affective changes after myelography: a comparison of metrizamide and iohexol.
A battery of brief cognitive tests and a mood scale were administered to 42 patients before and after cervical myelography with either metrizamide (20 patients) or iohexol (22 patients). The patients receiving metrizamide experienced a deterioration in mood after myelography and a relatively greater decline in cognitive test performance than did those receiving iohexol. These two side effects tended to occur together in the metrizamide group, suggesting a common underlying cause; but there was no correlation between changes in mood and cognitive function after myelography with iohexol. These results suggest that metrizamide has a greater neurotoxic effect than iohexol.
D000328:Adult; D003072:Cognition Disorders / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007463:Iodobenzoates / Q000009:adverse effects*; D007472:Iohexol; D008297:Male; D008793:Metrizamide / Q000009:adverse effects*; D008875:Middle Aged; D019964:Mood Disorders / Q000139:chemically induced*; D009192:Myelography; D011581:Psychological Tests; D014283:Triiodobenzoic Acids / Q000009:adverse effects*
D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007472:Iohexol; D008793:Metrizamide