[Polyclonal B cell activation in infection caused by human immunodeficiency virus (HIV)].
87 patients with anti-HIV antibodies were divided into three groups based on the classification of the Centers for Disease Control and the following parameters reflecting polyclonal B cell activation were evaluated in these patients: immunoglobulin levels, circulating immune complexes and occurrence of autoantibodies. The results reported here indicate that intense polyclonal B cell activation occurs in both asymptomatic (CDC 2) and symptomatic patients (CDC 3 and CDC 4). Moreover, serological abnormalities were detected with similar frequency in the three groups studied.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000914:Antibodies, Viral / Q000096:biosynthesis; D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000276:immunology*; D004247:DNA / Q000276:immunology; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies; D006679:HIV Seropositivity / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D015483:HIV Antibodies; D007136:Immunoglobulins; D004247:DNA
Activation polyclonale B associée à l'infection par le virus d'immunodéficience humaine (VIH).