The influence of synthetic tuftsin and its analogs on the function of granulocytes of children with acute lymphoblastic leukemia.
The effect of tuftsin, its synthetic analogs and arginine on phagocytosis of Staphylococcus aureus by granulocytes from leukemic children was investigated in vitro. The high stimulatory effect of tuftsin and arginine was shown. The decrease of phagocytosis of PMN from healthy subjects after preincubation with its analogs and arginine was observed, suggesting the regulatory effect of these peptides.
D000293:Adolescent; D001120:Arginine / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D007945:Leukemia, Lymphoid / Q000188:drug therapy* / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D014405:Tuftsin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D001120:Arginine; D014405:Tuftsin