Effect of baclofen on different models of bronchial hyperreactivity in the guinea-pig.
In this paper we report an inhibitory effect of (-)-baclofen on many models of bronchial hyperreactivity both in vivo and in vitro. (-)-Baclofen protects guinea-pigs from the anaphylactic bronchospasm induced in sensitized animals by an ovalbumin aerosol and from that induced by aerosols of histamine and PGF2 alpha. Moreover (-)-baclofen reduces the TXA2 and TXB2 output induced by ovalbumin from isolated sensitized guinea-pig lungs. On the other hand (-)-baclofen does not show antihistaminic, anticholinergic or antiprostaglandinic action on isolated tracheal preparations. It is concluded that baclofen can provide protection from bronchial hyperreactivity possibly through a modulation of autonomic nervous system activity.
D000109:Acetylcholine; D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D001418:Baclofen / Q000627:therapeutic use*; D001986:Bronchial Spasm / Q000139:chemically induced / Q000517:prevention & control*; D015237:Dinoprost; D006168:Guinea Pigs; D006633:Histamine Antagonists; D008168:Lung / Q000378:metabolism; D008297:Male; D011460:Prostaglandins F / Q000037:antagonists & inhibitors; D013928:Thromboxane A2 / Q000378:metabolism; D013929:Thromboxane B2 / Q000378:metabolism
D006633:Histamine Antagonists; D011460:Prostaglandins F; D013929:Thromboxane B2; D013928:Thromboxane A2; D015237:Dinoprost; D001418:Baclofen; D000109:Acetylcholine