A prospective evaluation of 118 patients with the fibromyalgia syndrome: prevalence of Raynaud's phenomenon, sicca symptoms, ANA, low complement, and Ig deposition at the dermal-epidermal junction.
One hundred eighteen consecutive patients with fibromyalgia were evaluated prospectively. Immunoglobulin deposits at the dermal-epidermal junction were found in only 4 of 36 patients. Twelve patients (14%) had at least one positive antinuclear antibody (ANA) test. Eight patients (7%) had at least one low C3. Thirty-five patients (30%) has a history of Raynaud's phenomenon and 22 (18%) had sicca symptoms, defined as symptomatic dry eyes and mouth and a positive Schirmer test. The 35 patients with Raynaud's phenomenon had a significantly higher prevalence of sicca symptoms, positive ANA or low C3 compared to the 83 patients who did not have Raynaud's phenomenon. Thus, a subset of patients with fibromyalgia may have features suggestive of a systemic connective tissue disorder.
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001327:Autoimmune Diseases / Q000145:classification; D003095:Collagen Diseases / Q000145:classification; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D005356:Fibromyalgia / Q000150:complications / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011928:Raynaud Disease / Q000209:etiology*; D012867:Skin / Q000276:immunology* / Q000473:pathology; D014985:Xerophthalmia / Q000209:etiology*; D014987:Xerostomia / Q000209:etiology*
D000974:Antibodies, Antinuclear; D007136:Immunoglobulins; D003165:Complement System Proteins