Synthesis and analgesic antiinflammatory activities of 2-aryl-ethenyl-4-aryl-thiazole-5-acetic acids.
A series of fifty-five 2-aryl-ethenyl-4-aryl-thiazole-5-acetic acids (IV-LVIII) were synthesized and evaluated for analgesic and antiinflammatory activities. Most of the synthesized compounds showed a good analgesic activity whereas some exhibited significant antiinflammatory activity.
D000085:Acetates / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013844:Thiazoles