Separation of the genetic loci for the H-Y antigen and for testis determination on human Y chromosome.
The mammalian Y chromosome encodes a testis-determining factor (termed TDF in the human), a master regulator of sex differentiation. Embryos with a Y chromosome develop testes and become males whereas embryos lacking a Y chromosome develop ovaries and become females. Expression of H-Y, a minor histocompatibility antigen, may also be controlled by a gene on the Y chromosome, and it has been proposed that this antigen is the testis-determining factor. We have tested the postulated identity of H-Y and TDF in the human. H-Y typing with T cells was carried out on a series of sex-reversed humans (XX males and XY females), each shown by DNA hybridization to carry part but not all of the Y chromosome. This deletion analysis maps the gene for H-Y to the long arm or centromeric region of the human Y chromosome, far from the TDF locus, which maps to the distal short arm.
D002872:Chromosome Deletion; D002874:Chromosome Mapping; D005260:Female; D006182:H-Y Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D012729:Sex Chromosome Aberrations / Q000235:genetics; D012732:Sex Determination Analysis; D013601:T-Lymphocytes / Q000276:immunology; D013737:Testis / Q000254:growth & development; D014178:Translocation, Genetic; D014998:Y Chromosome / Q000648:ultrastructure*
D006182:H-Y Antigen