Synthesis and pharmacological investigation of compounds containing a 2-thioxopyrrolidine-4,5-dione moiety.
The synthesis of two Schiff bases of aryl methyl ketones and ethylenediamine 1c, 1d, symmetric adducts of aryl isothiocyanates with Schiff bases 2d-2m and 2-thioxopyrrolidine-4,5-dione derivatives 4d-4m obtained by condensation of oxalyl chloride with Schiff bases of aroylthioacetic acid anilides and ethylenediamine is described. Some of 13 investigated compounds 4a, 4b, 4d-4l, 5a, 5b of 2-thioxopyrrolidine-4,5-dione type showed sedative and analgesic action.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants; D004347:Drug Interactions; D006380:Helplessness, Learned; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects
D000700:Analgesics; D000927:Anticonvulsants; D011759:Pyrrolidines; D006916:5-Hydroxytryptophan