[Immunocorrective therapy of the traumatic syndrome].
The effect of combined application of thymalin and plaferon in the prophylaxis and treatment of traumatic syndrome has been investigated in rats. The survival rate was taken as the criterion of efficiency, the mechanism of the effect obtained being estimated at the level of immunological protective factors. Traumatic shock was induced by Kennon's method in Wistar male rats weighing 200-250 g. Post-traumatic syndrome has been observed within 7 days. The combined application of thymalin and plaferon has increased the survival rate twice within the first 7 days. Immunomodulating effect of the combined application of thymalin and plaferon on the 7th day of traumatic syndrome was most marked at the level of total T-lymphocyte population, theophylline-sensitive T suppressors and lysozyme blood serum activity.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D007370:Interferon Type I / Q000627:therapeutic use; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012774:Shock, Traumatic / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013951:Thymus Hormones / Q000627:therapeutic use; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000936:Antigen-Antibody Complex; D007370:Interferon Type I; D013951:Thymus Hormones; C032805:thymalin
Immunokorrigiruiushchaia terapiia travmaticheskogo sindroma.