Synthesis and preliminary pharmacological screening of 4-methylamino-2-phenylquinoline-3-carboxamides.
Eight new 4-methylamino-2-phenylquinoline-3-carboxamides were obtained. Three of them were screened pharmacologically and all turned out to be antiinflammatory, analgesic and sedative compounds. Their properties were compared to those of indomethacin and pethidine.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000927:Anticonvulsants; D055598:Chemical Phenomena; D002621:Chemistry; D006993:Hypnotics and Sedatives; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010276:Parasympatholytics; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D010276:Parasympatholytics; D011804:Quinolines