Chronic nitrofurantoin reaction associated with T-lymphocyte alveolitis.
Nitrofurantoin use was associated with the development of severe interstitial lung disease which was characterized by bronchoalveolar lavage with a marked increase in lymphocytes to 60 percent (compared to normal of 7 +/- 1 percent). Lymphocytes were predominantly of the T-helper subset. Lavage may prove useful in the assessment of the immune response in drug-induced lung disease.
D000368:Aged; D005260:Female; D006801:Humans; D009582:Nitrofurantoin / Q000009:adverse effects*; D011650:Pulmonary Alveoli; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D013601:T-Lymphocytes
D009582:Nitrofurantoin