Association between polymorphic blood markers and risk factors for cardiovascular disease in a large pedigree.
A large pedigree with high prevalence of heart disease is investigated to analyse the association between polymorphic blood markers and quantitative risk factors for cardiovascular disease. The analysis incorporates a familial correlation structure among the individuals in the pedigree and a generalized power transformation to induce approximate residual normality of the risk factors. A total of 380 marker/risk factor combinations are analysed, and at the normal 1% significance level, positive associations are found between the A antigen of the ABO locus and both serum total cholesterol and low-density lipoprotein cholesterol, and negative associations are found between the B antigen of the ABO locus and serum total cholesterol, and between the B allele of acid phosphatase (AP) locus and systolic blood pressure.
D000017:ABO Blood-Group System / Q000235:genetics; D000135:Acid Phosphatase / Q000097:blood / Q000235:genetics; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology / Q000235:genetics*; D002784:Cholesterol / Q000097:blood / Q000235:genetics; D008078:Cholesterol, LDL / Q000097:blood / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors
D000017:ABO Blood-Group System; D008078:Cholesterol, LDL; D005819:Genetic Markers; D002784:Cholesterol; D000135:Acid Phosphatase