title: The effects of chronic administration of T4, growth hormone and epidermal growth factor on hepatic lipogenic enzymes in hypophysectomised rats.
abstract: The effect of daily injections of T4, growth hormone and epidermal growth factor on the activities of the 3 hepatic enzymes malic enzyme (E.C.1.1.1.40), 6 phosphogluconate dehydrogenase (E.C.1.1.1.44) and glucose 6-phosphate dehydrogenase (E.C.1.1.1.49) in hypophysectomised rats was examined. T4 was shown to increase the activity of malic enzyme in a dose dependent manner from a basal level of 3.55 mumol/min/liver to 48.97 mumol/min/liver at a dose of 75 micrograms/Kg/day. A smaller increase in the activity of 6 phosphogluconate dehydrogenase was also observed over the same range of T4 dosage. Growth hormone in the current study increased the total liver enzyme activity of glucose 6-phosphate dehydrogenase by 84% when given with a replacement dose of 35 micrograms T4/kg/day and 6 phosphogluconate dehydrogenase activity by 19%.
mesh_terms: D000818:Animals; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D013006:Growth Hormone / Q000494:pharmacology*; D007016:Hypophysectomy; D008099:Liver / Q000201:enzymology*; D008291:Malate Dehydrogenase / Q000378:metabolism; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*
chemical_list: D004815:Epidermal Growth Factor; D013006:Growth Hormone; D008291:Malate Dehydrogenase; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D013974:Thyroxine