title: In vivo efficacy of mebendazole in containment of larval cyst mass in early stages of hydatid disease due to Echinococcus granulosus.
abstract: The role of mebendazole in treatment of hydatid disease was investigated in a mouse model of human Echinococcus granulosus infection. Each animal received 2000 protoscoleces by intraperitoneal injection. Mebendazole, 50 mg/kg or 200 mg/kg body weight daily for 21 d, was given to 3 groups of animals 2, 4 and 6 months after infection. Significant decreases in numbers of cysts were seen in groups given the drug 2 and 4 months after infection, compared to the group given drug 6 months after infection. 200 mg/kg body weight was more effective in decreasing cyst numbers than 50 mg/kg.
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004443:Echinococcosis / Q000188:drug therapy* / Q000469:parasitology; D004446:Echinococcus / Q000187:drug effects; D008463:Mebendazole / Q000627:therapeutic use*; D051379:Mice
chemical_list: D008463:Mebendazole