Transforming growth factor-beta: biological function and chemical structure.
Transforming growth factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-beta and essentially all of them have specific receptors for this peptide. TGF-beta regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. Its marked ability to enhance formation of connective tissue in vivo suggests several therapeutic applications.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004815:Epidermal Growth Factor / Q000378:metabolism; D005796:Genes; D006801:Humans; D010455:Peptides / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D051381:Rats; D015291:Transforming Growth Factors
D010455:Peptides; D010982:Platelet-Derived Growth Factor; D004815:Epidermal Growth Factor; D015291:Transforming Growth Factors