[Morphological and biochemical studies of the effect of the peat-derived preparation PF-290/II/2 on the development of natural lymphatic leukemia in mice].
AKR mice highly susceptible to leukemia were fed orally for 9 months every days with a water solution of peat-liking preparation PF-290/II/2 at a dose 0.2 cm3 (70 g/cm3 water). After bleeding body and internal organs weight were measured and their ratio were calculated. Anatomo-pathological lesions, histopathological and ultrastructural examinations with the use of transmission and scanning microscope, serum cobalt-activated acylase (AA-Co) activity and urine arylsulphatase (ASA) activity were performed. It was found used preparation had some anti-tumors effect of mice with lymphatic leukemia. Serum cobalt-activated acylase and urine arylsulphatase of AKR mice for observation on disease development and dynamics of this process. In the ultrastructural picture changes of lymphatic cells after outside removal of degradated complexes of intracell membranes was observed.
D000581:Amidohydrolases / Q000097:blood*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001192:Arylsulfatases / Q000652:urine*; D005260:Female; D007945:Leukemia, Lymphoid / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008854:Microscopy, Electron; D012987:Soil; D013429:Sulfatases / Q000652:urine*
D000970:Antineoplastic Agents; D012987:Soil; D013429:Sulfatases; D001192:Arylsulfatases; D000581:Amidohydrolases; C019665:amidase
Badania morfologiczne i biochemiczne nad wpływem preparatu torfopochodnego PF-290/II/2 na rozwój naturalnej białaczki limfatycznej u myszy.