Interaction of carbon tetrachloride and progesterone metabolism in liver microsomes from triacetyloleandomycin-treated rats.
The production of progesterone metabolites by rat liver microsomes from TAO-treated rats was investigated. More than ten metabolites could be identified, including various dihydroxy-progesterones. CCl4 co-incubation modifies the P-450-dependent progesterone metabolite profile in a remarkable fashion without production of CCl4 progesterone adducts.
D000818:Animals; D002251:Carbon Tetrachloride / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014217:Troleandomycin / Q000633:toxicity*
D011374:Progesterone; D009249:NADP; D014217:Troleandomycin; D002251:Carbon Tetrachloride