Optimal conditions for injection of tobramycin and cefmenoxime into burn patients.
The concentrations of tobramycin (TOB) or cefmenoxime (CMX) in serum and burn blister fluid of 51 burn patients (21 for TOB, 30 for CMX) after an i.v. or i.m. injection were determined to find the optimal administration of TOB (2 mg/kg) or CMX (50 mg/kg). Among the various protocols tested, we found from the values of tAUC for TOB that a bolus i.v. injection, or 1-h drip infusion, or i.m. injection are recommended for systemic sepsis, however, the 1-h drip infusion is strongly suggested for treating wound surface infection. It has also been found that with CMX a bolus i.v. injection with a long period of efficacy is recommended for treating systemic sepsis, while a 1-h drip infusion or bolus i.v. injection was the best method for treating wound-surface infection.
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000517:prevention & control*; D002056:Burns / Q000150:complications*; D015281:Cefmenoxime; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D014031:Tobramycin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use
D015281:Cefmenoxime; D002439:Cefotaxime; D014031:Tobramycin