Evidence that dopamine receptors identified by [3H]dopamine in the ventricles of guinea-pig heart are of DA2 type.
Apomorphine and LY 171555, but not SKF 38393 displaced [3H]Dopamine binding to membranes of guinea-pig heart. Domperidone and 1-sulpiride but not SCH 23390 competitively antagonize the [3H]Dopamine binding performed with 100 microM cold dopamine as displacer. In conclusion the DA2 receptor agonists and antagonists used are able to interfere with the receptors labelled by [3H]Dopamine in cardiac muscle.
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D000818:Animals; D001058:Apomorphine / Q000378:metabolism; D001552:Benzazepines / Q000378:metabolism; D001667:Binding, Competitive; D004294:Domperidone / Q000378:metabolism; D004873:Ergolines / Q000378:metabolism; D006168:Guinea Pigs; D006352:Heart Ventricles / Q000378:metabolism; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism*; D019257:Quinpirole; D011954:Receptors, Dopamine / Q000378:metabolism*; D013469:Sulpiride / Q000378:metabolism
D001552:Benzazepines; D004873:Ergolines; D011954:Receptors, Dopamine; D019257:Quinpirole; D004294:Domperidone; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D013469:Sulpiride; D001058:Apomorphine