title: The demineralization of human dental roots in the presence of fluoride.
abstract: Intact roots of human molars, which had not been exposed to the oral environment, were exposed to buffer solutions of pH 5.5, which contained, besides calcium and phosphate, various concentrations of fluoride. Densitometric measurements on contact-microradiograms of transverse sections of these roots produced data which were used to calculate the rate of demineralization (Vdem). Vdem appeared to be reduced with increasing fluoride concentration and with decreasing pIOHA (i.e., the negative logarithm of the ionic product of hydroxyapatite) of the buffer solution. In addition, it was observed that, after some days of exposure, remineralization started to occur within the surface layer at some micron from the outer surface and that the region within which remineralization took place was extended inward with increasing time of exposure. These data suggest that fluoride is effective in the prevention of root surface caries. The mechanism of the interaction of fluoride with the root mineral is discussed.
mesh_terms: D000327:Adsorption; D002130:Calcium Phosphates / Q000494:pharmacology*; D002327:Cariostatic Agents; D003731:Dental Caries / Q000503:physiopathology*; D005459:Fluorides / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008903:Minerals / Q000378:metabolism; D012995:Solubility; D014092:Tooth Root / Q000187:drug effects* / Q000378:metabolism
chemical_list: D002130:Calcium Phosphates; D002327:Cariostatic Agents; D008903:Minerals; D005459:Fluorides