Relationship between bone GLA-protein (BGP) and calcidiol (25-hydroxycalciferol) in serum of breast-fed infants.
The aim of this investigation was to study the bone metabolism in early infancy by establishing the relationship between serum osteocalcin levels and the hormonal vitamin D status of exclusively breast-fed infants during their first month of life. Calcium, phosphorus, alkaline phosphatase, 25-hydroxycalciferol (calcidiol), 1,25-dihydroxycalciferol (calcitriol) and osteocalcin (BGP or GLA-protein) were measured in 22 healthy lactating women and their paired breast-fed infants before and after supplementation (400 IU vitamin D per day). Prior to supplementation calcidiol, calcitriol and osteocalcin remained unchanged. Following supplementation there was an increase in all the parameters with the exception of calcitriol. The administration of vitamin D to breast-fed infants should in fact have an effect on bone activity as reflected by the increase in osteocalcin levels.
D015652:25-Hydroxyvitamin D 2; D000469:Alkaline Phosphatase / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism; D001942:Breast Feeding; D002117:Calcitriol / Q000378:metabolism; D002118:Calcium / Q000097:blood; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D004872:Ergocalciferols / Q000031:analogs & derivatives* / Q000378:metabolism; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007774:Lactation; D015675:Osteocalcin; D010758:Phosphorus / Q000097:blood; D011247:Pregnancy
D002135:Calcium-Binding Proteins; D004872:Ergocalciferols; D015675:Osteocalcin; D015652:25-Hydroxyvitamin D 2; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002117:Calcitriol; D002118:Calcium