Spontaneous production of interleukin-2 in the supernatants of cultured cutaneous sarcoidal granulomas.
Biopsies of cutaneous sarcoidal lesions were cultured for 24 hr in vitro, and the cell-free supernatants were examined for the presence of T cell growth factor (IL-2). Low levels of IL-2 were detected in these supernatants based on their ability to support the growth of cultured T cells. The apparent molecular mass of the active component in these supernatants, as assessed by exclusion chromatography, was 14,900 daltons. These findings suggest that IL-2 production within these sarcoidal lesions may be partly responsible for their evolution and maintenance.
D001706:Biopsy; D002478:Cells, Cultured; D002850:Chromatography, Gel; D006099:Granuloma / Q000276:immunology*; D006801:Humans; D007376:Interleukin-2 / Q000032:analysis / Q000096:biosynthesis*; D008970:Molecular Weight; D012507:Sarcoidosis / Q000276:immunology*; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D007376:Interleukin-2