The influence of immune status on the in vitro sensitivity of serotoninergic receptors in the rat stomach strip.
Serotoninergic contractions of the rat stomach strip were evoked and EC50 determined. In preparations from control animals MDP, 50 mumol/l, decreased EC50 or sensitized the preparation. In the strips from animals where adjuvant arthritis was induced, higher sensitivity to 5-HT was observed and the sensitizing effect of MDP was retained. In the strips from animals pretreated with cyclophosphamide or in the terminal stage of tumor growth lower sensitivity to 5-HT, which could be further decreased by MDP, were noticed. These opposite effects in serotoninergic reactions were tentatively linked with the modulation of the immune status in vivo.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D005620:Freund's Adjuvant / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D011917:Rats, Inbred Lew; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects
D011985:Receptors, Serotonin; D012701:Serotonin; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D003520:Cyclophosphamide; D005620:Freund's Adjuvant