The control mechanisms of gastric emptying are not overridden by motor stimulants.
We wanted to determine if an acceleration of the normal emptying rate by motor stimulants interfers with control mechanisms limiting gastric emptying. Therefore, we studied the effects of 5-hydroxytryptophane (5-HTP) and cisapride on canine gastrointestinal motility and gastric emptying after ingestion of viscous acaloric and nutritive meals. Prolonged contractions and relaxations that change lumen size (isotonic component) and wall tension (isometric component) are defined as "basal contractions" and "basal relaxations", respectively. The nutrient meal emptied much slower than the acaloric meal due to several alterations of gastric, pyloric, and duodenal motility. Both drugs stimulated antral motility but failed to accelerate gastric emptying of the nutrient meal. The main causes for the failure were a basal relaxation of the proximal antrum and a basal contraction of the duodenum. In conclusion, basal contractions of the proximal antrum and duodenum play an important role in the process of gastric emptying, and under physiological conditions the control mechanisms of gastric emptying provide an optimal emptying rate that cannot be markedly accelerated by 5-HTP and cisapride.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D020117:Cisapride; D004285:Dogs; D004386:Duodenum / Q000187:drug effects / Q000502:physiology; D005746:Gastric Emptying / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D009119:Muscle Contraction; D009126:Muscle Relaxation; D010880:Piperidines / Q000494:pharmacology*; D013270:Stomach / Q000502:physiology
D010880:Piperidines; D006916:5-Hydroxytryptophan; D020117:Cisapride