TG and TnonG lymphocyte involvement in the proliferative response to PHA. I. Reactivity and regulatory functions of TG and TnonG subsets in the proliferative response of T lymphocytes.
Both TG and TnonG subpopulations from human peripheral blood were found to secrete helper and suppressor factors for the PHA-induced T cell proliferative response. The TnonG subpopulation contained cells which were both able to secrete helper factor and to respond by proliferation, whereas in the TG subpopulation cells with a proliferative potential could not be conclusively demonstrated. Suppressor and helper activities in TG and TnonG culture supernatants displayed a different time kinetics and were influenced by the dose of mitogen in test cultures.
D002478:Cells, Cultured; D004261:DNA Replication; D006801:Humans; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D010835:Phytohemagglutinins