Diphtheria, tetanus, pertussis: antibody detection in New Zealand.
Enzyme-linked immunosorbent assay (ELISA) tests were developed to detect IgG antibodies to diphtheria, tetanus, and pertussis in a healthy New Zealand population. Sera from 551 healthy persons aged 6-65 years from different areas in New Zealand were tested. Immunity to diphtheria decreased steadily from 97.1% in the 6-9 age group to 47.6% in the 60-65 age group. Immunity to tetanus varied from 88.6% in the 6-9 age group to 83.3% in the 20-29 age group, whence the level decreased with age to 57.1% in the 60-65 age group. In the teenage and adult groups more than 87.6% have antibodies to pertussis while in the 60-65 group it was 66.7%. There was great variation in the level of measurable antibody to pertussis in all age groups.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis*; D002648:Child; D004165:Diphtheria / Q000276:immunology* / Q000517:prevention & control; D004168:Diphtheria Toxoid / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008875:Middle Aged; D009520:New Zealand; D010567:Pertussis Vaccine / Q000276:immunology; D013742:Tetanus / Q000276:immunology* / Q000517:prevention & control; D013745:Tetanus Toxoid / Q000276:immunology; D014917:Whooping Cough / Q000276:immunology* / Q000517:prevention & control
D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations; D007074:Immunoglobulin G; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid