title: Vitamin A enhances forelimb regeneration in juvenile leopard frogs Rana pipiens.
abstract: The effect of retinoids on forelimb regeneration in the leopard frog, Rana pipiens, was examined by the topical application of a concentrated solution of vitamin A palmitate to the amputated left limb stumps of 30 froglets. This treatment resulted in the enhancement of regeneration; regenerative outgrowths of experimental frogs were more frequent, larger in size, and had improved morphology compared to their untreated control counterparts. We conclude that vitamin A palmitate, topically administered in concentrated dosages, exerts a positive effect on the regenerative capacity of Rana pipiens.
mesh_terms: D000671:Amputation, Surgical; D000818:Animals; D002356:Cartilage / Q000378:metabolism; D005121:Extremities / Q000502:physiology*; D011894:Rana pipiens; D012038:Regeneration; D014801:Vitamin A / Q000494:pharmacology*
chemical_list: D014801:Vitamin A