title: Changes of serum complement concentrations in tumour patients prior and after radiotherapy.
abstract: Peripheral blood concentrations of leucocytes, platelets and complement factors Clq, C3c, C3d, C4 and C5 were examined in 30 patients suffering from malignant tumours prior and after radiotherapy. In general, a decrease of blood cell concentrations as well as serum complement levels was noted using regression analysis. Two groups were formed: patients with (group I) and without (group II) foregoing tumour surgery. A positive correlation was found for all complement factors prior therapy in group I, whereas only some complement components did correlate in group II. The results in group I are in agreement with complements classical pathway activation. We conclude that the alternative pathways influence is responsible for the different results in group II.
mesh_terms: D003131:Combined Modality Therapy; D003166:Complement Activating Enzymes / Q000032:analysis; D015922:Complement C1q; D003176:Complement C3 / Q000032:analysis; D015932:Complement C3c; D015933:Complement C3d; D003181:Complement C4 / Q000032:analysis; D003182:Complement C5 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D007958:Leukocyte Count; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000532:radiotherapy* / Q000601:surgery; D010976:Platelet Count
chemical_list: D003176:Complement C3; D003181:Complement C4; D003182:Complement C5; D015922:Complement C1q; D015932:Complement C3c; D015933:Complement C3d; D003165:Complement System Proteins; D003166:Complement Activating Enzymes