title: Controlled ovulation in the marmoset monkey (Callithrix jacchus) with human chorionic gonadotropin following prostaglandin-induced luteal regression.
abstract: Controlled induction of ovulation in the marmoset monkey was attempted with a single injection of human chorionic gonadotropin (hCG; 50 IU) given on day 7 after prostaglandin-induced luteal regression. Animals given hCG (n = 12) ovulated within a 2-day period (days 9 and 10 after prostaglandin) compared with a 4-day period (days 9 to 12) in the control group (n = 12). The mean interval to ovulation was similar in both groups. There was no difference in the timing of the preovulatory estradiol (E2) peak between groups, although E2 levels on the day of hCG injection were lower than in controls on the day of the onset of the luteinizing hormone surge. All animals given hCG ovulated and 11 of 12 became pregnant. Ten of 11 embryos recovered surgically from six of these animals were normal blastocysts; 5 of the remaining 6 animals carried pregnancies to term. The results are of practical importance for experiments involving follicular and oocyte maturation and the collection and transfer of embryos.
mesh_terms: D000818:Animals; D002144:Callithrix; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D015237:Dinoprost; D004958:Estradiol / Q000097:blood; D005260:Female; D003341:Luteolysis / Q000187:drug effects*; D010062:Ovulation Induction; D011453:Prostaglandins / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology
chemical_list: D006063:Chorionic Gonadotropin; D011453:Prostaglandins; D011460:Prostaglandins F; D004958:Estradiol; D015237:Dinoprost