Activity of inosine analogs against Pneumocystis carinii in culture.
Three analogs of inosine, formycin B, allopurinol ribonucleoside, and 9-deazainosine, were tested for their ability to suppress proliferation of Pneumocystis carinii in culture with WI-38 cells. The organism was inhibited by 9-deazainosine at 10 micrograms/ml, and there was some inhibition at 1 microgram/ml. Formycin B was effective only at 40 micrograms/ml. Allopurinol ribonucleoside had little effect.
D000493:Allopurinol / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004338:Drug Combinations / Q000494:pharmacology; D005573:Formycins / Q000494:pharmacology; D007288:Inosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011010:Pneumocystis / Q000187:drug effects*; D051381:Rats; D012263:Ribonucleosides / Q000494:pharmacology; D013420:Sulfamethoxazole / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000981:Antiprotozoal Agents; D004338:Drug Combinations; D005573:Formycins; D012263:Ribonucleosides; C034561:formycin B; D007288:Inosine; D000493:Allopurinol; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; C048839:9-deazainosine; D014295:Trimethoprim; D013420:Sulfamethoxazole; C021958:allopurinol riboside