title: Heyde's syndrome: failure of a mechanical prosthesis and the possibility of a coagulation defect.
abstract: Recent data indicate that the gastrointestinal bleeding due to angiodysplasia associated with aortic stenosis (Heyde's syndrome) can be alleviated by aortic valve replacement with a bioprosthesis. This report details a situation in which valve replacement with a mechanical prosthesis and the subsequent anticoagulation promoted gastrointestinal bleeding from angiodysplastic lesions. Only when the mechanical prosthesis was replaced with a porcine prosthesis and the anticoagulation discontinued did the gastrointestinal bleeding stop.
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects; D001021:Aortic Valve; D001024:Aortic Valve Stenosis / Q000150:complications* / Q000601:surgery; D001165:Arteriovenous Malformations / Q000150:complications*; D001705:Bioprosthesis; D001778:Blood Coagulation Disorders / Q000150:complications*; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013577:Syndrome
chemical_list: D000925:Anticoagulants