Autoradiographic distribution of binding sites of [3H]SKF 38393, a selective dopamine D1 receptor agonist, in the mouse forebrain.
Distribution of binding sites of [3H]SKF 38393, a selective dopamine D1 receptor agonist, was studied on forebrain coronal sections of CXBI/ByJ mice by radioligand binding and digital subtraction autoradiography. Highest levels of [3H]SKF 38393 binding were detected in olfactory tubercle and caudate nucleus/putamen. Intermediate to low concentrations of receptors were indicated in cortex, amygdala, hypothalamus, claustrum, and septal area, whereas the lowest binding was found in white matter tracts (commissura anterior, corpus callosum). Analysis of data on caudate nucleus/putamen indicates a striosomal pattern of binding with a gradient of binding sites from medial to lateral caudate/putamen. The distribution of [3H]SKF 38393 binding sites corresponds to that of dopaminergic projection fields in the studied areas.
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D000818:Animals; D001067:Appetite Depressants / Q000378:metabolism; D001345:Autoradiography; D001552:Benzazepines / Q000378:metabolism*; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*; D014316:Tritium
D001067:Appetite Depressants; D001552:Benzazepines; D011954:Receptors, Dopamine; D014316:Tritium; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine