[Effect of oxidative metabolism inhibitors on ADH-dependent transport of water in the bladder of Rana temporaria].
It has been demonstrated that inhibitors of oxidative metabolism--rotenone, amytal, antimycin A, oligomycin and 2,4-dinitrophenol--block hydroosmotic response of the urinary bladder of the frog to pituitrin, cAMP and serosal hypertonicity caused by 200 mosm mannitol. Electron donors sodium ascorbate and phenasinemethasulphate completely abolish the inhibitory effect of rotenone and antimycin A (but not of oligomycin). It is concluded that intracellular reactions which are sensitive to the effect of the inhibitors of oxidative metabolism, begin from the step after cAMP formation.
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D005075:Biological Evolution; D001692:Biological Transport / Q000187:drug effects; D001834:Body Water / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D011896:Rana temporaria / Q000378:metabolism*; D001743:Urinary Bladder / Q000378:metabolism*; D014667:Vasopressins / Q000502:physiology*
D000963:Antimetabolites; D014667:Vasopressins
Vliianie ingibitorov okislitel'nogo metabolizma na ADG-zavisimyĭ transport vody v mochevom puzyre liagushki Rana temporaria.