Toxicity of imipenem in vitreous replacement fluid.
We evaluated the ocular toxicity of imipenem when administered in the infusion fluid during vitrectomy. Imipenem concentrations of up to 16 micrograms/mL were nontoxic to the ocular structures.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004596:Electroretinography; D015378:Imipenem; D011817:Rabbits; D012160:Retina / Q000187:drug effects*; D013845:Thienamycins / Q000633:toxicity*; D014821:Vitrectomy
D013845:Thienamycins; D015378:Imipenem