Utilization of cephalothin by Yersinia enterocolitica as sole carbon and energy source.
Two Yersinia enterocolitica strains were able to utilize the products of cephalothin degradation. The utilization of these products was shown by an increase of oxygen uptake by Y. enterocolitica with cephalothin as the only substrate, and by the growth of both strains with the hydrolysis products of cephalothin as sole energy and carbon sources. Nuclear magnetic resonance analysis of the cephalothin degradation reaction demonstrated the progressive disappearance of hydrolysis products. However, the products of benzylpenicillin degradation could not be utilized by Y. enterocolitica.
D001711:Biotransformation; D002512:Cephalothin / Q000378:metabolism*; D010101:Oxygen Consumption; D010400:Penicillin G / Q000378:metabolism; D015008:Yersinia enterocolitica / Q000378:metabolism*; D001618:beta-Lactamases / Q000378:metabolism
D001618:beta-Lactamases; D010400:Penicillin G; D002512:Cephalothin