The new formulation of I.C.I. 35868 (propofol) as the main agent for minor surgical procedures.
Thirty unpremedicated patients for day-case surgery were anaesthetized with 2.5 mg kg-1 of a new formulation of I.C.I. 35868 (propofol: Diprivan--I.C.I.) in a lipid emulsion. An initial bolus of fentanyl (1-1.5 micrograms kg-1) was given. Anaesthesia was maintained with intermittent boluses of propofol (1 mg kg-1) with no other agent added. The significant problems were: a high incidence of pain on injection (30%) and apnoea following induction lasting more than 30 s (57%). Cardiovascular depression was significant but not considered excessive. Recovery from the drug was rapid and uneventful, with no reported hangover effect.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004562:Electrocardiography; D005283:Fentanyl; D006801:Humans; D008875:Middle Aged; D013511:Minor Surgical Procedures; D008991:Monitoring, Physiologic; D010636:Phenols / Q000008:administration & dosage / Q000009:adverse effects; D015742:Propofol; D013997:Time Factors
D010636:Phenols; D005283:Fentanyl; D015742:Propofol