title: Sub-second striatal dopamine release measured by in vivo voltammetry.
abstract: High speed cyclic voltammetry was used to measure electrically stimulated striatal dopamine release in vivo with 25 ms time resolution. Dopamine release after 1 s stimulations was readily detectable and could be manipulated by drugs known to influence dopaminergic neurones. Using data-averaging dopamine release could be detected following stimulus trains as short as 100 ms. The use of carbon fibre microelectrodes gave a spatial resolution better than 5 micron.
mesh_terms: D000818:Animals; D001590:Benztropine / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004563:Electrochemistry; D008297:Male; D008474:Medial Forebrain Bundle / Q000502:physiology; D008787:Metoclopramide / Q000494:pharmacology; D010293:Pargyline / Q000494:pharmacology; D010479:Pergolide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001590:Benztropine; D010479:Pergolide; D010293:Pargyline; D008787:Metoclopramide; D002746:Chlorpromazine; D004298:Dopamine