S. aureus-induced B cell proliferation as a model for studying the effectiveness of immunosuppressive agents.
S. aureus Cowan-induced proliferation of human T lymphocytes was used as a model for evaluating the activity of most common immunosuppressants (steroids, cyclosporine and azathioprine). Methylprednisolone was found to be the most efficient steroid, followed by hydrocortisone and dexamethasone. Cyclosporine (CsA) was a potent inhibitor acting early after B cell stimulation. Azathioprine was found to have low effect on B cell activation.
D001379:Azathioprine / Q000494:pharmacology; D001402:B-Lymphocytes / Q000276:immunology*; D003524:Cyclosporins / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008775:Methylprednisolone / Q000494:pharmacology; D008954:Models, Biological; D013205:Staphylococcal Protein A
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D013205:Staphylococcal Protein A; D003907:Dexamethasone; D001379:Azathioprine; D008775:Methylprednisolone