The concentration of IgD in blood sera of children suffering from dys- or hypogammaglobulinaemia of class A.
6580 children inhabitans of selected region of Lower Silesia and 475 children with recurrent respiratory tract infections as well as 65 children with chronic active hepatitis were tested. IgA level was determined in each case. In the cases where IgA was absent or a low level of this immunoglobulin was found (0.2 g/l) IgD concentration was determined. It was established that the frequency of dysgammaglobulinaemia of class A was 1/731 tested cases in the tested population and 1/119 cases in children with respiratory tract infections and 1/65 tested children with chronic active hepatitis. Hypogammaglobulinaemia of class A was found in 1/365 cases in the tested population and 1/20 cases in children with respiratory tract infections and 2/65 children with chronic aggressive hepatitis. In children with dysgammaglobulinaemia of class A lack of IgD in serum was found in 44% of the cases--however, in hypogammaglobulinaemia IgA lack of IgD in serum was found in 38% of the cases.
D000293:Adolescent; D000361:Agammaglobulinemia / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007072:Immunoglobulin D / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D011044:Poland; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012016:Reference Values
D007072:Immunoglobulin D; D007074:Immunoglobulin G; D011947:Receptors, Antigen, B-Cell