Synthesis of an analog of human calcitonin gene related peptide, [Asu]-h-CGRP.
The analog of h-CGRP, des-Ala-deamino-dicarba-h-CGRP, was synthesized by the combination of the conventional solution and the solid phase peptide synthesis methods. This analog showed stronger and longer-lasting hypocalcemic and hypophosphatemic activities than the natural hormone.
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D002118:Calcium / Q000097:blood*; D006801:Humans; D007700:Kinetics; D008297:Male; D009479:Neuropeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000494:pharmacology; D010710:Phosphates / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D009479:Neuropeptides; D010446:Peptide Fragments; D010710:Phosphates; C053440:calcitonin gene-related peptide, Asu(2,7)-; D015740:Calcitonin Gene-Related Peptide; D002118:Calcium