Pituitary growth hormone from human cadavers: neurologic disease in ten recipients.
Creutzfeldt-Jakob disease (CJD) has been reported in three US patients previously treated with human growth hormone derived from large pools of human cadaver pituitary glands (pit-hGH). Neurologic disorders other than CJD occurred in 10 growth hormone-deficient patients treated with pit-hGH. These 10 cases could have been chance events or true syndromes; some cases may have been caused by transmissible agents contained in the pooled growth hormone product.
D000293:Adolescent; D000328:Adult; D002102:Cadaver; D005260:Female; D013006:Growth Hormone / Q000009:adverse effects* / Q000172:deficiency / Q000627:therapeutic use; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology*; D011129:Polyradiculoneuropathy / Q000209:etiology; D013132:Spinocerebellar Degenerations / Q000209:etiology
D013006:Growth Hormone