Oligozoospermia, asthenozoospermia, and sperm abnormalities in ex-addict to heroin, morphine, and hashish.
A 40-year-old male had been addicted to heroin, morphine, hashish, and other narcotics for 12 years. At examination, 2 years after abstinence from drugs, his semen analysis revealed oligozoospermia, asthenozoospermia, and morphologically abnormal spermatozoa such as "round-headed" and "kinked"--sperm with neck abnormalities and immature forms. There was no evidence of other morphological abnormalities or of the presence of morphologically normal sperm. A possible correlation is discussed between the long-lasting drug addiction and morphological sperm abnormality, endocrinological function, karyotype, and immunological status.
D000328:Adult; D005632:Fructose / Q000378:metabolism; D006062:Gonadotropins / Q000097:blood; D006556:Heroin Dependence / Q000150:complications*; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000150:complications*; D009021:Morphine Dependence / Q000150:complications*; D009845:Oligospermia / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000648:ultrastructure
D006062:Gonadotropins; D005632:Fructose