Structure and expression of the human calcitonin/CGRP genes.
Recently, we have reported the isolation of cDNA encoding a second human calcitonin gene-related peptide (hCGRP-II) [(1985) FEBS Lett. 183, 403-407]. In this report we describe the isolation and characterization of the gene encoding hCGRP-II. This gene, designated CALC-II, is structurally closely related to the known CALC-I gene encoding human calcitonin (hCT) and hCGRP-I. In contrast to CALC-I, CALC-II does not seem to be alternatively expressed. The formation of a second, hCT-like mRNA by differential splicing of CALC-II transcripts is unlikely in view of the structure of CALC-II, and could not be demonstrated in tissues known to express CALC-I and CALC-II.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002116:Calcitonin / Q000378:metabolism*; D015740:Calcitonin Gene-Related Peptide; D003001:Cloning, Molecular; D003360:Cosmids; D004247:DNA / Q000378:metabolism; D005796:Genes; D006801:Humans; D009479:Neuropeptides / Q000235:genetics*; D051381:Rats; D014158:Transcription, Genetic
D009479:Neuropeptides; D002116:Calcitonin; D004247:DNA; D015740:Calcitonin Gene-Related Peptide