title: The susceptibility to lysozyme of beta-lactamase-producing and non-producing derivatives of Staphylococcus aureus strain 1030.
abstract: The killing of Staphylococcus aureus strain 1030 and derived variants of it by lysozyme increased with increased lysozyme concentrations or decreased concentrations of sodium chloride. beta-Lactamase-producing and non-producing derivatives of strain 1030 were constructed. The former were less susceptible to lysozyme. Induction of beta-lactamase synthesis with 2-2'carboxyphenyl-benzoyl-6-penicillanic acid increased the resistance of producer strains to lysozyme. These results are discussed in relation to the spread of beta-lactamase-producing strains of S. aureus.
mesh_terms: D000332:Aerobiosis; D000693:Anaerobiosis; D007526:Isoelectric Point; D008826:Microbial Sensitivity Tests; D009113:Muramidase / Q000378:metabolism*; D010403:Penicillin Resistance; D013211:Staphylococcus aureus / Q000201:enzymology*; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D009113:Muramidase; D001618:beta-Lactamases