Leucovorine prevents methotrexate from inducing DNA lesions.
Methotrexate induces DNA strand fragmentation. We show here that the induction of DNA lesions can be overcome by treatment with leucovorine, a folic acid analogue.
D000230:Adenocarcinoma / Q000235:genetics; D002460:Cell Line; D003110:Colonic Neoplasms / Q000235:genetics; D004247:DNA / Q000032:analysis*; D004260:DNA Repair; D006801:Humans; D006863:Hydrogen-Ion Concentration; D002955:Leucovorin / Q000494:pharmacology*; D008727:Methotrexate / Q000494:pharmacology*; D013997:Time Factors
D004247:DNA; D002955:Leucovorin; D008727:Methotrexate