In vitro antibacterial activity of enoxacin, a new pyridonecarboxylic acid.
The antibacterial activity of enoxacin was determined against 1015 strains of Gram-positive and Gram-negative bacteria, mainly freshly isolated from clinical specimens. The minimum inhibitory concentrations (MIC 50-75-90) were determined in comparison to three commonly used antibiotics: ampicillin, cefotaxime and gentamicin. Enoxacin has shown a broad spectrum of action and antibacterial activity in general higher that than of three currently available antibiotics. The antibacterial activity seems similar to that of other quinolones of second generation.
D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002439:Cefotaxime / Q000494:pharmacology; D015365:Enoxacin; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009287:Naphthyridines; D015365:Enoxacin; D000667:Ampicillin; D002439:Cefotaxime