Comparison of 2 g single dose of metronidazole, nimorazole and tinidazole in the treatment of vaginitis associated with Gardnerella vaginalis.
Vaginitis associated with the presence of Gardnerella vaginalis (confirmed by culture) was treated either with metronidazole or with one of the two nitroimidazole derivatives; nimorazole or tinidazole, as a single oral 2 g dose. Eighty-two patients were treated with metronidazole, 100 with nimorazole and 98 with tinidazole. The cure rates were 79%, 88% and 92% with metronidazole, nimorazole and tinidazole respectively. Therefore we recommend a single dose of 2 g of any of these three drugs in the treatment of such infection.
D005260:Female; D006194:Gardnerella vaginalis / Q000187:drug effects; D006192:Haemophilus Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D009554:Nimorazole / Q000627:therapeutic use*; D009593:Nitroimidazoles / Q000627:therapeutic use*; D012008:Recurrence; D014011:Tinidazole / Q000627:therapeutic use*; D014627:Vaginitis / Q000188:drug therapy*
D009593:Nitroimidazoles; D014011:Tinidazole; D008795:Metronidazole; D009554:Nimorazole