[Metronidazole content of normal and tumor tissues in the combined treatment of patients with osteogenic sarcoma].
A study was made of the time course of the level of metronidazole in the blood and tissues of 97 patients with localized osteogenic sarcoma in several modes of the drug administration (per os, using an enema and their combinations). The maximum drug concentration in the blood was achieved with the combined mode of the drug administration at a dose of 8 g/m2, enhancing local and general effects on a tumor, manifesting themselves in the reduction of sizes of a tumor, its morphological changes and an increase in the average period of metastasis detection. The 3-year survival rates showed no significant differences between groups of patients receiving and not receiving metronidazole.
D000293:Adolescent; D000328:Adult; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D007700:Kinetics; D008795:Metronidazole / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism; D008875:Middle Aged; D012516:Osteosarcoma / Q000032:analysis* / Q000378:metabolism / Q000401:mortality / Q000628:therapy; D011300:Preoperative Care; D011879:Radiotherapy Dosage; D013997:Time Factors; D014018:Tissue Distribution
D008795:Metronidazole
Soderzhanie metronidazola v normal'nykh i opukholevykh tkaniakh pri kombinirovannom lechenii bol'nykh s osteogennoĭ sarkomoĭ.