Specific effect of age on lectin-induced mitogenesis of lymphocytes from diseased patients.
Using several models of multivariate analysis, it is found that age per se is a specific determinant on the in vitro lymphocyte response to phytohemagglutinin A in a random sample of 30 diseased patients. Depending upon the used model, sex and lymphocyte subsets appear as other significant variables. The multiple regression coefficients reach 0.85. A 2% fall per decade is expected for phytohemagglutinin A responsiveness expressed in 1n cpm.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D000818:Animals; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007152:Immunologic Capping; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology*; D012044:Regression Analysis; D012737:Sex Factors; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects*
D010835:Phytohemagglutinins