HLA-DR2 and narcolepsy.
A positive association between HLA-DR2, DQw1, and narcolepsy was documented in 23 French caucasoid narcoleptic patients, 18 who were heterozygous for DR2 and 5 who were possibly homozygous. An autoimmune mechanism of narcolepsy is proposed with three successive stages, as well as relevant methodology for further investigation. A dominant mode of inheritance of narcolepsy, with an incomplete penetrance, is suggested although not yet evidenced.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases; D005260:Female; D005799:Genes, Dominant; D006683:HLA-DQ Antigens; D015802:HLA-DR2 Antigen; D006579:Heterozygote; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic
D006683:HLA-DQ Antigens; D015802:HLA-DR2 Antigen; D000949:Histocompatibility Antigens Class II