[Comparative analysis of the subpopulation of immunocompetent cells and the secretory IgA system in neonatal and maternal milk].
To examine the local immunity of the newborn and maternal mammary glands the distribution of regulatory lymphocyte subsets, Ia-positive cells, free secretory component (Sc) and secretory IgA (SIgA) has been studied in maternal and neonatal milk. In the maternal milk there was a positive correlation between the relative number of Ia-positive cells and the level of SIgA, and a reverse correlation between the percentage of cytotoxic (suppressor) cells and free Sc level. No such correlations were observed on the neonatal milk. A high level of It-positive cells in the neonatal milk suggests a high functional activity of the local immunity in the mammary gland of the newborn. A high Sc level and a very low SIgA level were found in the neonatal milk. The relative immaturity and autonomy of the local immunity were observed in the neonatal mammary gland.
D003126:Colostrum / Q000276:immunology*; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D007231:Infant, Newborn; D008895:Milk, Human / Q000276:immunology*; D011247:Pregnancy; D012635:Secretory Component / Q000032:analysis; D013601:T-Lymphocytes / Q000145:classification*
D007071:Immunoglobulin A, Secretory; D012635:Secretory Component
Sravnitel'naia analiz subpopuliatsii immunokompetentnykh kletok i sistemy sekretornogo IgA neonatal'nogo i materinskogo moloka.