title: Chemotaxis of rat retinal glia to growth factors found in repairing wounds.
abstract: Retinal glia migrate to sites in the vitreous body and on the inner and outer surfaces of the retina during a wide variety of pathological processes. Using in vitro cultures of rat retinal glia, we have evaluated an extensive list of homogeneous, well-characterized growth factors as chemoattractants for these cells. Humoral growth factors, fibroblast growth factors, extracellular matrix proteins and immune system cytokines all were without activity except for the platelet-derived growth factor (PDGF). Extracts of bovine ocular tissues including vitreous body and retina yielded significant activity.
mesh_terms: D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects; D005123:Eye / Q000032:analysis; D006133:Growth Substances / Q000494:pharmacology / Q000502:physiology*; D009457:Neuroglia / Q000502:physiology*; D051381:Rats; D011917:Rats, Inbred Lew; D012160:Retina / Q000166:cytology*; D014020:Tissue Extracts / Q000494:pharmacology; D014945:Wound Healing
chemical_list: D006133:Growth Substances; D014020:Tissue Extracts