Effects of dietary supplementation on autoimmunity in the MRL/lpr mouse: a preliminary investigation.
The effects of dietary fatty acid supplementation on various disease parameters in the spontaneously autoimmune MRL-mp-lpr/lpr mouse model of systemic lupus erythematosus before onset of disease were investigated. A fat deficient diet was supplemented with the following oils: olive oil, sunflower oil, evening primrose oil (EPO), fish oil, and a fish oil/EPO mixture. The mice receiving a diet enriched with EPO showed an increase in survival, as did those receiving the fish oil/EPO mixture. These results, taken together with those of the other parameters monitored, suggest that EPO may be of benefit in alleviating the murine form of the disease.
D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D004247:DNA / Q000276:immunology; D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use; D008041:Linoleic Acids; D008180:Lupus Erythematosus, Systemic / Q000178:diet therapy* / Q000276:immunology / Q000401:mortality; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D031665:Oenothera biennis; D009821:Oils / Q000627:therapeutic use*; D000069463:Olive Oil; D010938:Plant Oils / Q000627:therapeutic use; D012217:Rheumatoid Factor / Q000032:analysis; D000074242:Sunflower Oil; D017965:gamma-Linolenic Acid
D000974:Antibodies, Antinuclear; D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D008041:Linoleic Acids; D009821:Oils; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil; C028498:evening primrose oil; D017965:gamma-Linolenic Acid; D004247:DNA; D012217:Rheumatoid Factor