M-cholinergic receptors in mice B-lymphocytes in the process of immune response.
With the help of the radioactive blocker of M-cholinergic receptors 3H-Quinuclidinil benzylate their quantity was determined on B-lymphocytes of CBA mice spleen. On the 3rd and 4th day after immunization with ovalbumin the number of M-cholinergic receptors became somewhat higher. The specific antigen decreased the expression of M-cholinergic receptors on B-lymphocytes most of all on the 4th day after immunization, and did not have any effect on this indicator in control animals. This testifies to the possibility of steric interaction between the antigen binding immunoglobulin and M-cholinergic receptors on B-lymphocytes during the immune reaction.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000032:analysis*; D007114:Immunization; D007958:Leukocyte Count; D051379:Mice; D008808:Mice, Inbred CBA; D011950:Receptors, Cholinergic / Q000032:analysis*
D011950:Receptors, Cholinergic