Crossreactivity of anti Lyt-2.2 monoclonal antibody with some Lyt-2.2-negative mouse strains.
We observed that thymocytes from some Ly-2a (i.e., Lyt-2.2-) mouse strains crossreacted with high concentrations of anti Lyt-2.2 monoclonal antibody HO.2.2, whereas other Ly-2a strains were clearly negative. Inbred strains from two breeding colonies (Wrocław and Bombay) exhibited the same pattern of reactivity with HO.2.2. The nature of crossreacting antigen is discussed.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000950:Antigens, Ly / Q000276:immunology; D003429:Cross Reactions; D005260:Female; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000950:Antigens, Ly; D007518:Isoantibodies; C029805:Lyt antibodies