Spontaneous recurrent fetal wastage and autoimmune abnormalities: a study of fourteen cases.
Case records of 14 women with spontaneous recurrent fetal wastage were analyzed. Venous and/or arterial thrombosis developed in nine patients and vasospastic symptoms in eight. Every patient had some kind of autoantibodies: prothrombin activation inhibitor was present in seven cases, anticardiolipin in five, and, antimitochondrial antibodies in two. Antinuclear antibodies were present in seven cases, and significant titer of antibodies to single-stranded DNA in nine cases. With a mean follow up of 6.5 years no patient developed systemic lupus erythematosus. It is suggested that such women have a peculiar form of vasculitis.
D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications*; D002308:Cardiolipins / Q000276:immunology; D002467:Cell Nucleus / Q000276:immunology; D004247:DNA / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011247:Pregnancy; D011516:Prothrombin / Q000037:antagonists & inhibitors; D013927:Thrombosis / Q000150:complications
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D002308:Cardiolipins; D011516:Prothrombin; D004247:DNA