Interleukin-1 derived from human monocytic leukemia cell line JOSK-I acts as an autocrine growth factor.
Interleukin-1 (IL-1) enhances the growth of human monocytic leukemia cell line JOSK-I cells, which were recently established in our laboratory and which were demonstrated to produce a high level of IL-1 constitutively, in liquid as well as semisolid culture systems. Concomitantly, IL-1 stimulated the prostaglandin E2 synthesis and nitroblue tetrazolium dye-reducing capacity of JOSK-I cells. This indicates that IL-1 may act as autocrine growth factor for monocytes, and also suggests the possibility that this autocrine stimulation may play an important role in the pathophysiology of monocytic leukemia in vivo.
D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis; D015232:Dinoprostone; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D007951:Leukemia, Myeloid / Q000473:pathology / Q000503:physiopathology*; D009000:Monocytes / Q000502:physiology*; D011458:Prostaglandins E / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000494:pharmacology
D006133:Growth Substances; D007375:Interleukin-1; D011458:Prostaglandins E; D011994:Recombinant Proteins; D004247:DNA; D015232:Dinoprostone