title: Histological analysis of lymphocyte subsets infiltrated into mouse tumor tissue exposed to local irradiation.
abstract: The subsets of lymphocytes infiltrated into mouse tumor tissue exposed to irradiation were analyzed by the avidin-biotin-peroxidase procedure using monoclonal antibodies. The effect of PSK administration was also analyzed. Microscopic observation revealed the intense lymphocytic reactions in the exposed tumor, especially 7 days after irradiation of 20 Gy, which mainly consisted of anti-L3T4 positive cells, whereas the degree of infiltration was lower in the nonexposed tumor. PSK was found to enhance T lymphocyte subset infiltration into the exposed tumor tissue.
mesh_terms: D000818:Animals; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy*; D011509:Proteoglycans / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D013601:T-Lymphocytes / Q000145:classification / Q000473:pathology*
chemical_list: D011509:Proteoglycans; C010770:polysaccharide-K