Impact of smoking on the concentration and activity of alpha-1-antitrypsin in serum in relation to the urinary excretion of hydroxyproline.
The impact of active and passive smoking on the serum levels of alpha 1-AT, the trypsin inhibitory capacity (TIC), the trypsin inhibitory activity (TIA) and the urinary hydroxyproline to creatinine ratio (HOP-ratio) was studied. The subjects used in the study on active smoking were 167 healthy adult men and in the study on passive smoking 189 healthy primary school children. Serum levels of alpha 1-AT in active smokers were significantly higher than those in non-smokers. The TIC as well as the TIA in active smokers decreased with increasing number of cigarettes smoked. The urinary HOP-ratio increased significantly with increasing number of cigarettes smoked. On the other hand, in the case of passive smokers a significant difference was obtained only for the HOP-ratio. The correlations between all markers in active smokers were significant. Less significant correlations were found in the case of passive smokers. These results suggest that the urinary excretion of hydroxyproline can be considered as a marker for the imbalance between proteases and anti-proteases as a result of smoking.
D000328:Adult; D002648:Child; D003238:Connective Tissue / Q000473:pathology; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012907:Smoking; D014028:Tobacco Smoke Pollution; D000515:alpha 1-Antitrypsin / Q000097:blood*
D014028:Tobacco Smoke Pollution; D000515:alpha 1-Antitrypsin; D006909:Hydroxyproline