Evaluation of the in vivo and in vitro calcium-regulating actions of noncalcitonin peptides produced via calcitonin gene expression.
Recent studies of rat and human calcitonin (CT) gene expression have uncovered a diversity of secretory peptides. Here we report the results of testing two such non-CT secretory peptides for CT-like action in live rats and in cultured fetal rat long bone. One peptide, the carboxyl-terminal CT-adjacent peptide that is cosynthesized with CT, has no hypocalcemic effect and no inhibitory action on bone resorption in vitro. The other peptide, CT gene-related peptide, lowers blood calcium and inhibits bone resorption. In vitro experiments are consistent with the idea that CT gene-related peptide is acting at CT receptors in bone.
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects; D001842:Bone and Bones / Q000196:embryology / Q000378:metabolism; D002116:Calcitonin / Q000235:genetics* / Q000494:pharmacology*; D015740:Calcitonin Gene-Related Peptide; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002132:Calcium Radioisotopes; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D010281:Parathyroid Hormone / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D012323:RNA Processing, Post-Transcriptional; D051381:Rats; D011919:Rats, Inbred Strains
D002132:Calcium Radioisotopes; D009419:Nerve Tissue Proteins; D010281:Parathyroid Hormone; D010446:Peptide Fragments; C037553:katacalcin; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide; D002118:Calcium