title: Cyclosporin-induced gingival overgrowth: correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva.
abstract: Gingival overgrowth, dental plaque, and gingivitis were assessed by means of standardized semiquantitative indices in thirty renal transplant patients undergoing immunosuppression with cyclosporin-A (Cy-A). Radioimmunoassay techniques were used to determine Cy-A in serum samples and in parotid, submandibular, and whole saliva samples from each patient. A significant positive correlation was found between gingival overgrowth scores and both dental plaque and gingivitis scores. A significant positive correlation was found between whole-saliva Cy-A and both plaque and gingival overgrowth scores. No such correlation was found when parotid Cy-A or submandibular Cy-A was considered. This was attributed to differences in saliva-collection methods, and a possible role of dental plaque as a local reservoir of Cy-A is proposed.
mesh_terms: D000328:Adult; D003524:Cyclosporins / Q000009:adverse effects / Q000032:analysis* / Q000097:blood; D003773:Dental Plaque / Q000175:diagnosis*; D003774:Dental Plaque Index; D005260:Female; D005885:Gingival Hyperplasia / Q000139:chemically induced*; D005891:Gingivitis / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D012463:Saliva / Q000032:analysis*
chemical_list: D003524:Cyclosporins