title: Effects of triiodothyronine on the development of GFAP-immunoreactivity and CAT-activity in monolayer cultures of embryonal rat forebrain cells.
abstract: Dose-dependent actions of triiodothyronine were studied in serum-containing primary cultures of embryonal rat forebrain cells. Triiodothyronine at concentrations exceeding the normal medium concentration by 2 and 5 nM failed to cause significant changes in the development of CAT-activity and GFAP-immunoreactivity. In the presence of additional 10 and 20 nM T3, however, CAT-activity was increased and GFAP-immunoreactivity was decreased in comparison to cultures maintained with 'normal' (10% FCS-containing) media.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D005625:Frontal Lobe / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014284:Triiodothyronine / Q000494:pharmacology*
chemical_list: D005904:Glial Fibrillary Acidic Protein; D014284:Triiodothyronine; D002795:Choline O-Acetyltransferase