Assessment of antimicrobial penetrance into the pancreatic juice in humans.
The penetrance of mezlocillin, metronidazole and trimethoprim-sulfamethoxazole into the pancreatic juice of humans was measured in ten patients convalescing from acute pancreatitis at the time of endoscopic retrograde cholangiopancreatography. Therapeutic levels were obtained in the serum for all three antimicrobial agents; simultaneously aspirated nonbile stained pancreatic juice contained therapeutic levels of metronidazole and trimethoprim-sulfamethoxazole. Mezlocillin was not present in a therapeutic level in any patient with nonbile stained pancreatic fluid.
D000208:Acute Disease; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004338:Drug Combinations / Q000032:analysis; D004341:Drug Evaluation; D006801:Humans; D008795:Metronidazole / Q000032:analysis*; D008802:Mezlocillin / Q000032:analysis*; D010182:Pancreatic Diseases / Q000000981:diagnostic imaging; D010183:Pancreatic Ducts / Q000000981:diagnostic imaging; D010189:Pancreatic Juice / Q000032:analysis*; D010192:Pancreatic Pseudocyst / Q000000981:diagnostic imaging; D010195:Pancreatitis / Q000188:drug therapy; D013420:Sulfamethoxazole / Q000032:analysis*; D014295:Trimethoprim / Q000032:analysis*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; D008795:Metronidazole; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D008802:Mezlocillin