Platelet aggregation induced by cryoprecipitate infusion in platelet-type von Willebrand's disease.
Platelet-type von Willebrand's disease (VWD) is a recently described bleeding disorder characterized by a heightened interaction between platelets and von Willebrand factor (vWF) as the result of an intrinsic platelet-membrane abnormality. Administration of cryoprecipitate into a patient with this disorder was followed by thrombocytopenia in vivo and "spontaneous" platelet aggregation in vitro. However, a prolonged bleeding time was shortened and sufficient haemostasis was achieved without thromboembolic complications. These results provide evidence that human vWF infused with cryoprecipitate directly interacts with platelet-type vWD platelets, causing thrombocytopenia in vivo, and suggest that impaired primary haemostasis is related to the depletion of the high-molecular-weight vWF multimers in the circulating plasma.
D006487:Hemostasis; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation; D010976:Platelet Count; D013921:Thrombocytopenia / Q000209:etiology; D014842:von Willebrand Diseases / Q000097:blood* / Q000145:classification / Q000628:therapy; D014841:von Willebrand Factor / Q000008:administration & dosage*
D014841:von Willebrand Factor