Penetration of imipenem into human aqueous and vitreous humor.
Twenty-five patients about to undergo cataract surgery and ten patients about to undergo vitrectomy received a 1-g intravenous dose of imipenem before surgery. Specimens of aqueous or vitreous humor were then obtained and assayed for antibiotic content with a microbiologic disk agar technique. A mean peak aqueous humor level of 2.99 micrograms/ml was found at approximately two hours after administration, and a mean vitreous level of 2.53 micrograms/ml was found from two hours to three hours 15 minutes after administration. These concentrations were well above the minimum inhibitory concentration of imipenem for 90% (MIC90) of Staphylococcus epidermidis, S. aureus, and the Enterobacteriaceae commonly involved in bacterial endophthalmitis.
D001082:Aqueous Humor / Q000378:metabolism*; D009877:Endophthalmitis / Q000097:blood / Q000378:metabolism; D006801:Humans; D015378:Imipenem; D009325:Nausea / Q000139:chemically induced; D009994:Osmolar Concentration; D013845:Thienamycins / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D014822:Vitreous Body / Q000378:metabolism*
D013845:Thienamycins; D015378:Imipenem