Post-proline cleaving enzyme in human cerebrospinal fluid from control patients and parkinsonian patients.
PPCE activity was found in human CSF by using a HPLC-fluorescence method. PPCE activity in CSF from control patients without neurological diseases was 2.19 +/- 0.78 (mean +/- SD) pmole (hr)-1.(ml)-1. PPCE activity in CSF from patients with Parkinson's disease was significantly decreased while PPCE activity in serum did not change significantly.
D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010300:Parkinson Disease / Q000134:cerebrospinal fluid / Q000201:enzymology*; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000134:cerebrospinal fluid*; D013050:Spectrometry, Fluorescence
D012697:Serine Endopeptidases; C000705287:PREPL protein, human; D000085822:Prolyl Oligopeptidases