The idiotypy of auto anti-allotype antibody induced in immunoglobulin allotype suppressed rabbits.
Rabbit anti-rabbit idiotype antibody was raised to both clonally heterogeneous and restricted auto anti-b6 antibodies induced in b6 allotype-suppressed (b6)/(b6) homozygous and b4/(b6) heterozygous rabbits. In every case the anti-idiotypic antibodies were specific only for the inducing antibody as shown by direct binding solid-phase RIA. Anti-idiotypes directed to the same antibody preparation had a similar but not identical specificity. It was demonstrated by IEF that the same idiotype specificity (spectrotype) was present throughout the anti-b6 response in individual rabbits.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000918:Antibody Specificity; D001323:Autoantibodies / Q000276:immunology*; D006384:Hemagglutination; D007126:Immunoglobulin Allotypes / Q000276:immunology*; D007130:Immunoglobulin Idiotypes / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains; D007525:Isoelectric Focusing; D011817:Rabbits; D013489:Suppression, Genetic
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D007126:Immunoglobulin Allotypes; D007130:Immunoglobulin Idiotypes; D007145:Immunoglobulin kappa-Chains; C496591:kappa allotype b4, rabbits