title: Endoneurial capillary permeability to [14C]sucrose in frog sciatic nerve.
abstract: Using an in situ perfusion technique, we measured the [14C]sucrose permeability-surface area product (PA) in endoneurial capillaries of 48 frog sciatic nerves, as 6.6 +/- 0.6 (S.E.M.) X 10(-5) s-1, and the vascular space as 1.31 +/- 0.10%. Assuming A = 30 cm2/g, P = 2.2 X 10(-6) cm/s. P for sucrose was greater than P in some barrier tissues with tight junctions, but was less than P in all capillaries examined so far except rat cerebral capillaries. These observations demonstrate that endoneurial capillaries are an effective part of the blood-nerve barrier to water-soluble non-electrolytes. The findings are consistent with capillary impermeability to microperoxidase and with capillary ultrastructure.
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D003238:Connective Tissue / Q000033:anatomy & histology / Q000098:blood supply* / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism / Q000502:physiology; D005260:Female; D009929:Organ Size; D010477:Perfusion; D011894:Rana pipiens; D012584:Sciatic Nerve / Q000033:anatomy & histology / Q000098:blood supply* / Q000378:metabolism; D013395:Sucrose / Q000378:metabolism*
chemical_list: D013395:Sucrose