[In vivo study of the protective action of the splenocytes from CBA strain mice immunized with an inactivated nonconcentrated rabies vaccine].
An inactivated unconcentrated rabies vaccine was demonstrated to induce the production of T-killers which in adoptive transfer protect 38-43% of recipients challenged intramuscularly with street rabies virus. The production of T-killers depends on the dose and schedule of the antigen inoculation. T-killers in vivo were strictly specific and manifested their protective effect only in syngeneic but not in allogeneic system.
D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D007116:Immunization, Passive / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA / Q000276:immunology*; D011819:Rabies Vaccines / Q000276:immunology*; D013154:Spleen / Q000276:immunology* / Q000637:transplantation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014613:Vaccines, Attenuated / Q000276:immunology
D011819:Rabies Vaccines; D014613:Vaccines, Attenuated
Izuchenie in vivo zashchitnogo deĭstviia splenotsitov mysheĭ linii CBA, immunizirovannykh inaktivirovannoĭ nekontsentrirovannoĭ antirabicheskoĭ vaktsinoĭ.