Induction of class I and class II transplantation antigens in rat brain during fatal and non-fatal measles virus infection.
Measles virus induced a marked increase in the expression of MHC-coded class I and class II antigens as detected by immunostaining during both fatal and non-fatal brain infections in rats. The distribution of these molecules in the brain was much more widespread than the occurrence of viral antigen suggesting a soluble factor for their induction. In 14-day-old rats with a non-fatal infection there was a marked infiltration of T lymphocytes of 'cytotoxic/suppressor' phenotype in the brain parenchyma, whereas T 'helper' cell phenotypes mainly were located perivascularly. In brains from newborn rats with a fatal infection no or only few lymphocytes were detected.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D006681:HLA-D Antigens / Q000032:analysis*; D008214:Lymphocytes / Q000276:immunology; D008285:Major Histocompatibility Complex; D008457:Measles / Q000276:immunology* / Q000401:mortality; D008459:Measles virus / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D011917:Rats, Inbred Lew
D000956:Antigens, Viral; D006680:HLA Antigens; D006681:HLA-D Antigens