An outbreak of Candida parapsilosis endophthalmitis: analysis of strains by enzyme profile and antifungal susceptibility.
Twenty-two isolates from patients with postsurgical endophthalmitis due to infection with Candida parapsilosis as a result of exposure to a contaminated ocular irrigating solution were classified by enzyme profile analysis and antifungal susceptibility. These isolates were identical to a single isolate obtained from a contaminated vial but could be differentiated, on the basis of enzyme profile and antifungal susceptibility, from randomly selected stock isolates. The combination of these tests appears to have value in discriminating epidemic from non-epidemic strains.
D000666:Amphotericin B / Q000494:pharmacology; D002175:Candida / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification*; D002177:Candidiasis / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology*; D004196:Disease Outbreaks; D004340:Drug Contamination; D009877:Endophthalmitis / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology*; D005437:Flucytosine / Q000494:pharmacology; D006801:Humans; D007654:Ketoconazole / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011183:Postoperative Complications / Q000382:microbiology*
D008825:Miconazole; D000666:Amphotericin B; D005437:Flucytosine; D007654:Ketoconazole