Oral Zn-DTPA therapy for reducing 141Ce retention in suckling rats.
In neonatal rats DTPA reduced the intestinal retention of cerium ingested as an additive in its chloride form to milk. It also reduced retention of absorbed cerium. A similar decrease of cerium retention in gut and whole body was obtained after simultaneous or 24 hours' delayed DTPA administration.
D000818:Animals; D000833:Animals, Suckling; D001822:Body Burden; D002563:Cerium / Q000378:metabolism* / Q000493:pharmacokinetics; D007413:Intestinal Mucosa / Q000378:metabolism; D004369:Pentetic Acid / Q000627:therapeutic use*; D051381:Rats; D014018:Tissue Distribution; D015032:Zinc
D002563:Cerium; D004369:Pentetic Acid; D015032:Zinc