A comparison of combined diphtheria, tetanus and pertussis vaccines produced by different manufacturers, in laboratory animals and in infants.
Three DTP vaccines were investigated for potency and toxicity (reactogenicity) both in laboratory animals and in infants. Animal tests were carried out in conformity with the WHO recommendations. Three- to five-month-old infants were investigated for their specific antibody responses and for local and systemic vaccination reactions. No correlation was found between the potency values of the vaccines as expressed in IUs and the antibody titres of the vaccinated infants. The most striking difference between the human and animal responses to vaccination was observed in the case of the tetanus toxoid. The severity of the vaccination reactions in infants correlated with the toxicity of the vaccines as assessed in the mouse weight gain test (MWGT) carried out in CBA mice. No correlation was found, however when conventional or AKR mice were used in the MWGT.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001835:Body Weight / Q000187:drug effects; D004168:Diphtheria Toxoid / Q000009:adverse effects / Q000494:pharmacology* / Q000592:standards; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations / Q000009:adverse effects / Q000494:pharmacology / Q000592:standards; D006168:Guinea Pigs; D006801:Humans; D007223:Infant; D051379:Mice; D008815:Mice, Inbred Strains; D010567:Pertussis Vaccine / Q000009:adverse effects / Q000494:pharmacology* / Q000592:standards; D013045:Species Specificity; D013745:Tetanus Toxoid / Q000009:adverse effects / Q000494:pharmacology* / Q000592:standards
D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations; D010567:Pertussis Vaccine; D013745:Tetanus Toxoid