Suppression of overt diabetes in NOD mice by anti-thymocyte serum or anti-Thy 1, 2 antibody.
Effects of anti-thymocyte serum (ATS) and anti-Thy 1, 2 monoclonal antibody on the spontaneously occurring diabetes in NOD mice were examined. Spontaneous diabetes in female mice was markedly suppressed by intravenous injection of rabbit anti-mouse thymocyte serum diluted to 1:4 on three consecutive days during the time period from 70 to 100 days after birth; the cumulative incidence of overt diabetes upto 195 days of age was greatly reduced and the onset of diabetes was delayed. Similar effect was observed with anti-Thy 1, 2 antibody treatment. These findings suggest that T lymphocytes play a role in the production of spontaneous diabetes in this mouse strain.
D000818:Animals; D000961:Antilymphocyte Serum / Q000276:immunology*; D003921:Diabetes Mellitus, Experimental / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D007108:Immune Tolerance; D007518:Isoantibodies / Q000276:immunology*; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology
D000961:Antilymphocyte Serum; D007518:Isoantibodies; C035678:anti-Thy antibody