HLA antigens in 88 cases of rheumatic fever observed in Martinique.
HLA-A, B, C and DR antigens were studied in 88 patients from Martinique. A modest but significant reduction of B14 and Bw42 antigens was noted as well as an increase in B35 (p less than 0.05) and DR1 antigens (corrected p less than 0.05), two antigens known to be in linkage disequilibrium. These data, which corroborate a previous study for B35, suggest that the unusual antistreptococcal response mounted by rheumatic fever patients is under HLA control.
D005602:France; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens; D059909:HLA-B14 Antigen; D015797:HLA-B35 Antigen; D006681:HLA-D Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D015798:HLA-DR1 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D012213:Rheumatic Fever / Q000276:immunology*
D006680:HLA Antigens; D015235:HLA-B Antigens; D059909:HLA-B14 Antigen; D015797:HLA-B35 Antigen; C489636:HLA-B42 antigen; D006681:HLA-D Antigens; D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D000949:Histocompatibility Antigens Class II