Intraocular pressure and aqueous humor dynamics in rabbit and primate with d- and 1-adrenergic compounds.
The effects of the d- and 1-isomers of epinephrine and norepinephrine have been determined on intraocular pressure (IOP) in conscious rabbits and rhesus monkeys, and on aqueous humor turnover rate (AHTR) in rabbits. Relatively specific beta-adrenergic antagonists (butoxamine and metoprolol) were used to attempt to modify the responses. The effects on IOP in both species are similar to those of racemic mixtures. The d- and 1-isomers of norepinephrine and epinephrine reduced IOP, and reduced AHTR in rabbits. The d- and 1-isomers of norepinephrine had little effect on IOP in monkeys while d- and 1-epinephrine increased IOP. Metoprolol, a beta 1-antagonist was more effective than butoxamine (beta 2-antagonist) at modifying the effect of the norepinephrine isomers in rabbits.
D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects*; D002078:Butoxamine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology*; D007429:Intraocular Pressure / Q000187:drug effects*; D008253:Macaca mulatta; D008790:Metoprolol / Q000494:pharmacology; D011817:Rabbits; D013045:Species Specificity; D013237:Stereoisomerism
D002078:Butoxamine; D008790:Metoprolol; D004837:Epinephrine