title: Malignant transformation in oral leukoplakia.
abstract: A retrospective study on the incidence of malignant transformation in oral leukoplakia was performed covering the period from 1970 to 1980. Carcinoma developed in 11 of the 157 patients, and this 7% incidence increased to 8.9% when the same patients were followed prospectively for 6 more years. Dysplasia was found in biopsies from 51 patients (31.8%), and was significantly more frequent in women than men (P less than 0.05). Dysplasia grade and cancer development were related to updated clinical and etiological parameters.
mesh_terms: D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007972:Leukoplakia, Oral / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009664:Norway; D011446:Prospective Studies; D012189:Retrospective Studies