title: Pharmacokinetics of superselective intra-arterial and intravenous [11C]BCNU evaluated by PET.
abstract: The pharmacokinetics of i.v. and superselective intra-arterial carbon-11 1,3-bis-(2-chloroethyl)-1-nitrosourea ([11C]BCNU) were directly compared for the first time in ten patients with recurrent gliomas using positron emission tomography (PET). Intra-arterial administration of [11C]BCNU achieved concentrations of the drug in the tumor that averaged 50 times higher than with a comparable i.v. dose. These preliminary results suggest that the degree of early metabolic trapping of BCNU in tumor correlates with the clinical response to this chemotherapy.
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002250:Carbon Radioisotopes; D002330:Carmustine / Q000008:administration & dosage / Q000097:blood*; D004341:Drug Evaluation; D005260:Female; D005910:Glioma / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006207:Half-Life; D006801:Humans; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D002330:Carmustine