Pharmacological study of the new mucolytic drug N-guanyl-cysteine.
The pharmacological evaluation of N-guanyl-cysteine (IQB-782) is reported. This new cysteine derivative shows a potent mucolytic-expectorant activity in different test systems. Thus, IQB-782 protects rats against tobacco-smoke-induced respiratory airway obstruction, increases the tracheo-bronchial mucus secretion in rabbits and increases the pulmonary excretion of fluorescein in mice, an index of broncho-secretagogue activity. Like other mucolytics, IQB-782 is also effective in vitro in reducing the viscosity of a suspension of gastric mucin. This new drug is apparently devoid of any cardiovascular or autonomic activity and shows a moderate CNS depressant effect. IQB-782 is consequently a new thiol derivative which may offer some advantages in the treatment of different types of obstructive pulmonary disease.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D001991:Bronchitis / Q000209:etiology / Q000503:physiopathology*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005100:Expectorants / Q000494:pharmacology*; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011597:Psychomotor Performance / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D014783:Viscosity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D005100:Expectorants; C049592:N-guanylcysteine; D003545:Cysteine