Rapid decrease in amino acid metabolism in prolactin-secreting pituitary adenomas after bromocriptine treatment: a PET study.
Four patients with prolactin-secreting pituitary adenomas were examined with positron emission tomography using L-[11C]methionine to monitor the effect of dopamine agonist treatment on the amino acid metabolism in the tumors. Within the first few hours after intramuscular injection of bromocriptine retard (50 mg) the amino acid metabolism decreased by 40%. Two of the patients were reexamined 7 and 9 days later and showed a 70% reduction in the metabolism of the adenomas. This metabolic effect was later accompanied by significant tumor shrinkage in all adenomas. It is suggested that bromocriptine has a general and rapid effect on the protein synthesis of the prolactin-secreting pituitary adenoma cells.
D000236:Adenoma / Q000097:blood / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D000596:Amino Acids / Q000097:blood*; D001971:Bromocriptine / Q000627:therapeutic use*; D002250:Carbon Radioisotopes; D006801:Humans; D008279:Magnetic Resonance Imaging; D008715:Methionine; D010911:Pituitary Neoplasms / Q000097:blood / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D013997:Time Factors; D014055:Tomography, Emission-Computed
D000596:Amino Acids; D002250:Carbon Radioisotopes; D001971:Bromocriptine; D011388:Prolactin; D008715:Methionine