A derivative of an ataxia-telangiectasia (A-T) cell line with normal radiosensitivity but A-T-like inhibition of DNA synthesis.
Ataxia-telangiectasia (A-T) cells are hypersensitive to the lethal effects of ionizing radiation and fail to inhibit DNA synthesis following radiation exposure. A cell line derived from an A-T line following DNA-mediated gene transfer has normal radiation sensitivity, but the kinetics of DNA synthesis after gamma-irradiation are similar to those of A-T cells.
D001260:Ataxia Telangiectasia / Q000235:genetics*; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D004247:DNA / Q000096:biosynthesis*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D010641:Phenotype; D011836:Radiation Tolerance
D003037:Cobalt Radioisotopes; D004247:DNA