Modulation of mitogen-induced lymphoproliferation by cerebral neocortex.
The influence of the cerebral neocortex on the immunological status was studied in groups of C3H/He mice after lesioning the right or left fronto-parietal cortex. In left lesioned mice, mitogenesis induced either by phytohemagglutinin (PHA) or concanavalin A (Con A) was depressed by about 50% compared to controls. On the contrary, in animals with right lesions, T cell mitogenesis was enhanced by about 140% as compared to controls and by 220-300% as compared to that observed in left lesioned animals. Mitogenesis of B cells induced by lipopolysaccharide was modified by cortical lesions in exactly the same way as that of T cell proliferation although not reaching statistical significance. These results confirm the lateralization in the cortical modulation of the immune system.
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology; D002540:Cerebral Cortex / Q000502:physiology*; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D051379:Mice; D008809:Mice, Inbred C3H; D008934:Mitogens / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000166:cytology
D008070:Lipopolysaccharides; D008934:Mitogens; D010835:Phytohemagglutinins; D003208:Concanavalin A