Effect of prostaglandins E2 and 15-methyl F2 alpha on human pregnant and non-pregnant cervix.
Forty-two women of reproductive age were studied in two equal groups (group I, first-trimester pregnant; group II, non-pregnant). Each group included three equal sub-groups; subgroup A received intra-cervical 15-Me PGF2 alpha gel, B received intracervical PGE2 gel and C received intra-cervical gel alone as placebo. Three different staining techniques were employed to study the histological picture and histochemical alterations of cervical biopsies. These showed that PG-treated cervices presented significant changes compared to placebo in terms of more widely dissociated connective tissue bundles that are separated by clear spaces and an increase in the amount of ground substance. Moreover, the observed changes in pregnant sub-groups were more evident than in the corresponding non-pregnant cases.
D000287:Administration, Topical; D000328:Adult; D002260:Carboprost / Q000494:pharmacology*; D002584:Cervix Uteri / Q000033:anatomy & histology / Q000187:drug effects*; D003238:Connective Tissue / Q000033:anatomy & histology / Q000187:drug effects; D015232:Dinoprostone; D005260:Female; D005782:Gels; D006801:Humans; D011247:Pregnancy / Q000187:drug effects*; D011261:Pregnancy Trimester, First; D011458:Prostaglandins E / Q000494:pharmacology*; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*
D005782:Gels; D011458:Prostaglandins E; D011461:Prostaglandins F, Synthetic; D002260:Carboprost; D015232:Dinoprostone