Enhanced induction by X-irradiation of DNA double-strand breakage in mitotic as compared with S-phase V79 cells.
A marked enhancement of X-ray-induced DNA double-strand breakage was demonstrated for mitotic Chinese hamster (V79) cells compared with S-phase cells or asynchronous cultures, which can explain the high radiosensitivity of mitotic cells. However, mitotic cells required twice the level of DNA double-strand breakage to produce a lethal lesion of that required for S-phase or asynchronous cells, suggesting that repair in mitotic cells is less error prone.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D007399:Interphase / Q000528:radiation effects*; D008938:Mitosis / Q000528:radiation effects*; D011836:Radiation Tolerance
D004247:DNA