Protective effect(s) of rIL-2 modulation. I. The effects of chemotherapeutic/cytotoxic agents on human natural killer cells and lymphokine-activated killer cells.
This study investigated whether in vitro immunotherapy with rIL-2 which augments human natural cytotoxicity and generation of lymphokine-activated killer cells diminished or inhibits the severity of therapeutically induced human in vitro NK immunosuppression. We demonstrate that rIL-2 induces a rapid and potent enhancement of cytolytic killing and that pretreatment of effector cells for one hour with rIL-2 yields effector cells which are more resistant to drug-induced immunosuppression. Additionally, we demonstrate cells pretreated for 24 hours with rIL-2 were less sensitive to drug inhibitory effects than rIL-2 non-treated or one hour pretreated effector cells. Our data suggest prophylactic treatment with IL-2 for drug induced immunosuppression is feasible.
D000970:Antineoplastic Agents / Q000009:adverse effects*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D006801:Humans; D007165:Immunosuppression Therapy; D007167:Immunotherapy; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000276:immunology* / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008222:Lymphokines / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000628:therapy
D000970:Antineoplastic Agents; D007376:Interleukin-2; D008222:Lymphokines