Tumor-associated antigen is expressed on lymphocytes from patients with acquired immunodeficiency syndrome.
Monoclonal antibody BE2 recognizes an antigen found on malignant T4+ lymphocytes from cutaneous T-cell lymphoma patients (CTCL). Normal peripheral blood lymphocytes do not express detectable levels of BE2 antigen. Forty-eight percent of patients with the acquired immunodeficiency syndrome (AIDS) had lymphocyte populations that were reactive with monoclonal antibody BE2. Peripheral blood lymphocytes from healthy homosexuals, patients with classical Kaposi's sarcoma or viral syndromes, and healthy normal controls were BE2-. Double-labeling studies demonstrated that BE2+ cells were T lymphocytes. This observation demonstrates that some AIDS patients as well as CTCL patients have circulating cells that express a common lymphocyte abnormality.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000368:Aged; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D005260:Female; D006716:Homosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012514:Sarcoma, Kaposi / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm