Prolongation of the action potential and reduction of the delayed outward K+ current by halothane in single frog atrial cells.
Halothane has been shown to produce significant changes in heart rate and strength of contraction. We have studied the mechanism(s) of these effects by recording action potentials and transmembrane ionic currents in single cardiac cells from bullfrog atrium. Our results show that the action potential was prolonged and its plateau was depressed; and that there was a significant inhibition of a potassium current, Ik, and a Ca2+ current, Isi, following halothane (2%) application.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D016275:Atrial Function; D006221:Halothane / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D011188:Potassium / Q000378:metabolism*; D011892:Rana catesbeiana
D011188:Potassium; D006221:Halothane