Prostaglandin production by human myometrium, uterine cervix and leiomyoma.
In order to investigate prostacyclin production by human myometrium, uterine cervix and leiomyoma, slices of each tissue were incubated. The 6-keto prostaglandin F1 alpha concentration of the incubation medium was measured by radioimmunoassay. The serosal and endometrial sides of myometrium produce 6-keto prostaglandin F1 alpha, with no significant difference in production between the two sides. The 6-keto PGF1 alpha production of leiomyoma was significantly higher than that of myometrium. Our results suggest that human myometrium and leiomyoma produce prostacyclin regardless of vascularization.
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis*; D002584:Cervix Uteri / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D007889:Leiomyoma / Q000378:metabolism*; D009092:Mucous Membrane / Q000378:metabolism; D009215:Myometrium / Q000378:metabolism*; D014594:Uterine Neoplasms / Q000378:metabolism*
D015121:6-Ketoprostaglandin F1 alpha