title: On a prezygotic origin of normal/balanced translocation mosaics.
abstract: Based on a theoretical model for the production of some structural mosaicisms, the authors propose a mechanism for the origin of normal/balanced translocation mosaics. Single strand breaks and nonhomologous hemichromatid joining are implicated and, when applied to homologous chromosomes, could explain some instances of nondisjunction independent of centromere function.
mesh_terms: D006801:Humans; D009030:Mosaicism; D009630:Nondisjunction, Genetic; D014178:Translocation, Genetic