Impaired cutaneous delayed-type hypersensitivity in autoimmune MRL lpr/lpr mice.
A number of phenotypic and functional T-cell abnormalities have been reported in autoimmune MRL lpr/lpr (MRL/l) mice. We examined hapten-specific delayed-type hypersensitivity (DTH) responses in male and female MRL/l mice and compared them to age- and sex-matched congeneic MRL +/+ (MRL/n) mice and outbred Swiss controls. Profound defects in DTH reactivity were demonstrated in female MRL/l mice at all ages tested. In contrast MRL/l males displayed only partly impaired and selective DTH defect toward one of the two haptens used. Congeneic MRL/n females expressed lower DTH reactivity than their male littermates. We conclude that DTH responses in autoimmune MRL/l mice are defective and sex hormone related.
D000367:Age Factors; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D010081:Oxazolone / Q000276:immunology; D010853:Picryl Chloride / Q000276:immunology; D012867:Skin / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D010081:Oxazolone; D010853:Picryl Chloride