title: Biochemical study of whole saliva from children with chronic renal failure.
abstract: The biochemical composition of unstimulated whole saliva was studied on ten children suffering from chronic renal failure and who, at the same time, displayed a very low caries activity. Various salivary components were studied before (T) and after (To) dialysis and were compared with similar elements of a control group, as well as with blood values. A mean salivary urea concentration of 513 +/- 210 mg/100 ml was found prior to dialysis, whereas after treatment this value dropped to 241 +/- 82 mg/100 ml, about twice as much as in the control group, 110 +/- 48 mg/100 ml. The mean urea concentrations in blood at T and To were respectively 196 +/- 38 mg/100 ml and 53 +/- 22 mg/100 ml. The various free amino acids in the whole saliva of these patients showed different changes in their concentrations as a result of dialysis, with the basic amino acids being considerably increased. Blood electrolytes remained close to the normal range, although calcium was depleted and magnesium lowered by a factor of 10 when compared before and after dialysis, as well as versus the control group.
mesh_terms: D000293:Adolescent; D000596:Amino Acids / Q000032:analysis / Q000097:blood; D002648:Child; D004573:Electrolytes / Q000032:analysis / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000378:metabolism*; D008297:Male; D006435:Renal Dialysis; D012463:Saliva / Q000032:analysis*; D014508:Urea / Q000032:analysis / Q000097:blood
chemical_list: D000596:Amino Acids; D004573:Electrolytes; D014508:Urea