Effects of ketoprofen on release of prostaglandin F2 alpha from uterus of rat in perinatal period.
The effects of oral administration of ketoprofen, indomethacin, (0.1, 1.0 and 3.0 mg/kg), naproxen, flurbiprofen, (0.1 and 1.0 mg/kg), and acetylsalicylic acid (10 and 100 mg/kg) on release of prostaglandin F2 alpha (PGF2 alpha) from isolated pregnant Sprague-Dawley rat uterus and on plasma PGF2 alpha' 17 beta-estradiol and progesterone levels were studied comparatively. The plasma PGF2 alpha level and the rate of release of PGF2 alpha from isolated rat uterus increased progressively from day 18 to 20 of gestation. Ketoprofen, indomethacin, flurbiprofen, naproxen and acetylsalicylic acid reduced the release of PGF2 alpha from the isolated rat uterus and the rise in plasma PGF2 alpha level, and the effects seem to be dose-dependent. A comparative study with intramuscular ketoprofen (0.1 and 1.0 mg/kg) was also carried out. The inhibitory effect of ketoprofen on uterine PGF2 alpha release with intramuscular route was 15.9 times more profound than that with oral route. The anti-inflammatory drugs tested except acetylsalicylic acid were also found to hinder the drop of plasma progesterone level in the late stage of pregnancy but not affect the plasma 17 beta-estradiol level. These results suggest that reduction of PGF2 alpha release from the uterus induced by treatment with these nonsteroidal anti-inflammatory drugs might result in the delay of spontaneous delivery.
D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D015237:Dinoprost; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000097:blood; D005260:Female; D066298:In Vitro Techniques; D007273:Injections, Intramuscular; D007660:Ketoprofen / Q000008:administration & dosage / Q000494:pharmacology*; D010666:Phenylpropionates / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D011374:Progesterone / Q000097:blood; D011460:Prostaglandins F / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D010666:Phenylpropionates; D011460:Prostaglandins F; D011374:Progesterone; D004958:Estradiol; D007660:Ketoprofen; D015237:Dinoprost