title: Suppression of antipyretic response in rabbits by intraventricular protein synthesis inhibitor, anisomycin.
abstract: Fevers induced by intravenous injection of endogenous pyrogen (EP) and intraventricular prostaglandin E2 (PGE2) were significantly prolonged when protein synthesis inhibitor, anisomycin was administrated intraventricularly 30 min before or 1 hr after injection of EP or PGE2. The present results show that protein synthesis in the central nervous system is involved in the development of antipyresis.
mesh_terms: D000818:Animals; D000841:Anisomycin / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000037:antagonists & inhibitors*; D015232:Dinoprostone; D007276:Injections, Intraventricular; D008297:Male; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011458:Prostaglandins E; D011759:Pyrrolidines; D000841:Anisomycin; D015232:Dinoprostone