title: About the porcine TSH receptor.
abstract: Using a number of immunologic and biochemical approaches, we have identified a number of [125I]bTSH binding peptides with Mr approximately 45,000, 66,000-70,000, approximately 95,000; larger conjugates capable of binding the hormone have not been excluded. A conservative interpretation of the data suggest a basic receptor unit of Mr approximately 95,000 of which Mr 45,000 and 66,000-70,000 are proteolytic products of membrane-bound proteases. The association of two intact subunits by strong noncovalent forces may generate more than 3 TSH binding sites.
mesh_terms: D000818:Animals; D000906:Antibodies; D000936:Antigen-Antibody Complex / Q000032:analysis; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D008854:Microscopy, Electron; D008970:Molecular Weight; D011989:Receptors, Thyrotropin / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism*; D013552:Swine; D013961:Thyroid Gland / Q000166:cytology / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D000906:Antibodies; D000936:Antigen-Antibody Complex; D011989:Receptors, Thyrotropin