Mutation in the VP-1 gene is responsible for the extended host range of a monkey B-lymphotropic papovavirus mutant capable of growing in T-lymphoblastoid cells.
Monkey B-lymphotropic papovavirus (LPV) replicates only in B-lymphoblastoid cells, whereas the LPV mutant 76 (LPV-76) can grow in either B- or T-lymphoblastoid cells. The nucleotide sequence of the wild-type LPV PstI B segment was compared with that of LPV-76 PstI-B, within which the mutation responsible for the extended host range had been located. The VP-1 coding region of LPV-76 was found to have mutations, single-base substitutions causing three amino acid substitutions.
D000818:Animals; D001402:B-Lymphocytes / Q000382:microbiology*; D001483:Base Sequence; D002213:Capsid / Q000235:genetics*; D002522:Chlorocebus aethiops; D004742:Enhancer Elements, Genetic; D005814:Genes, Viral; D009154:Mutation; D027383:Papillomaviridae / Q000235:genetics* / Q000254:growth & development; D027382:Polyomaviridae; D011991:Receptors, Virus / Q000502:physiology; D013601:T-Lymphocytes / Q000382:microbiology*; D014779:Virus Replication
D011991:Receptors, Virus