Effect of some endodontic sealers on cell migration in experimental granulomas.
CRCS or calciobiotic root canal sealer (a calcium hydroxide-based sealer), Proco-sol and Tubliseal (both zinc oxide eugenol-based sealers), and Diaket-A (a polyvinyl-based sealer) were assessed for their relative cytotoxicities by their different cell migration effects by means of glass coverslip granulomas. Cytotoxicity was assessed by means of the influx of mononuclear cells or macrophages and their transformation into multinucleate giant cells. CRCS was shown to be the best sealer, followed by Proco-sol and Tubliseal. Diaket-A was the most cytotoxic of the sealers tested.
D000818:Animals; D001729:Bismuth / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D006099:Granuloma / Q000473:pathology*; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology; D011145:Polyvinyls / Q000494:pharmacology; D051381:Rats; D011917:Rats, Inbred Lew; D012117:Resins, Synthetic / Q000494:pharmacology; D012387:Root Canal Filling Materials / Q000494:pharmacology*; D012871:Skin Diseases / Q000473:pathology*; D015034:Zinc Oxide / Q000494:pharmacology; D015035:Zinc Oxide-Eugenol Cement
D004338:Drug Combinations; D011145:Polyvinyls; D012117:Resins, Synthetic; D012387:Root Canal Filling Materials; D015035:Zinc Oxide-Eugenol Cement; C014457:bismuth phosphate, copolymers of vinyl acetate, dichlorophen, propionyl-acetophenone, triethanolamine, vinyl chloride, vinylisobutyl ether, zinc oxide drug combination; C035615:Proco-Sol; C048769:tubliseal; D015034:Zinc Oxide; D001729:Bismuth