title: Complement and anaphylatoxin responses to cross-clamping of the aorta. Studies during general anaesthesia with or without extradural blockade.
abstract: Complement activation and anaphylatoxin formation were studied in 28 patients undergoing aortic reconstructive surgery under general anaesthesia. In 12 of the patients an extradural catheter was placed in the L1-2 space and 2% mepivacaine was injected until blockade reached the T4 level. The remaining 16 patients were operated upon under general anaesthesia alone. Complement activation was not obvious until aortic cross-clamping. The release of anaphylatoxin was less pronounced during cross-clamping in the extradural group.
mesh_terms: D000368:Aged; D000706:Anaphylatoxins / Q000032:analysis*; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D001011:Aorta / Q000502:physiology*; D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis; D015926:Complement C3a; D003182:Complement C5 / Q000032:analysis; D015936:Complement C5a; D003250:Constriction; D005260:Female; D006801:Humans; D008297:Male; D010455:Peptides / Q000032:analysis*; D011446:Prospective Studies
chemical_list: D000706:Anaphylatoxins; D003176:Complement C3; D003182:Complement C5; D010455:Peptides; D015926:Complement C3a; D015936:Complement C5a