T cell subsets in idiopathic glomerulonephritis.
Determination of T lymphocyte subsets using monoclonal antibodies revealed a deficiency of suppressor cells and an elevated helper:suppressor T cell ratio in 7 patients with untreated idiopathic immune complex glomerulonephritis and nephrotic syndrome. Possible pathogenetic mechanisms of immunoregulatory cell imbalance and their implications specifically in reference to idiopathic glomerulonephritis are discussed.
D000328:Adult; D000911:Antibodies, Monoclonal; D003602:Cytotoxicity, Immunologic; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification*; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology
D000911:Antibodies, Monoclonal