Tomographic mapping of kinetic rate constants in the fluorodeoxyglucose model using dynamic positron emission tomography.
A quick computing algorithm to calculate the rate constants (k*1, k*2, k*3) in the [18F]2-fluoro-2-deoxy-D-glucose (FDG) model was developed. The algorithm solved for the rate constants pixel by pixel using a conventional least-squares method and two tables consisting of a set of various rate constants, to shorten the computing time. Five planes of rate constant images were obtained. A combined study using the dynamic FDG method and the 15O-labeled gas continuous inhalation method was performed on seven healthy male volunteers aged 26-35 years. Results indicated an apparent discrepancy between CMRglu and CMRO2 in the cerebellum, where the low glucose utilization was correlated with a low FDG phosphorylation rate (k*3) despite a sufficient FDG transportation rate (k*1) from plasma to tissue.
D001345:Autoradiography / Q000379:methods*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008297:Male; D008959:Models, Neurological; D010101:Oxygen Consumption; D014055:Tomography, Emission-Computed
D003837:Deoxy Sugars; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose