Anticonvulsant role of adenosine.
The effects of 2-chloroadenosine (2-CLA), a metabolically stable analog of adenosine, and aminophylline, an adenosine receptor antagonist, on seizures produced by pilocarpine (PILO) were examined in rats. The effects of 2-CLA on amygdaloid and hippocampal kindled seimres were also examined. In the animals pretreated with aminophylline (25-100 mg/kg), a non-convulsant dose of PILO (100 mg/kg) resulted in severe motor limbic seizures which rapidly evolved to status epilepticus. 2-CLA (5-10 mg/kg) blocked the appearance of behavioral and EEG seizures produced by a convulsant dose of PILO (380 mg/kg) and completely blocked the evolution of hippocampal and amygdaloid kindled seizures. The results indicate that purinergic mechanisms are involved in the modulation of seizure threshold within the limbic system.
D015762:2-Chloroadenosine; D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology*; D000628:Aminophylline / Q000494:pharmacology; D000679:Amygdala / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D000818:Animals; D000927:Anticonvulsants; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology*
D000927:Anticonvulsants; D010862:Pilocarpine; D015762:2-Chloroadenosine; D000628:Aminophylline; D000241:Adenosine