Failure of hyperketonemia to alter basal and insulin-mediated glucose metabolism in man.
The effect of physiologic elevations of plasma hydroxybutyrate induced by the infusion of sodium D,L-beta-hydroxybutyrate (15 mumol X kg-1 X min-1) on carbohydrate metabolism was examined with the euglycemic insulin clamp technique in nine healthy volunteers. Plasma insulin concentration was acutely raised and maintained at 126 +/- 6 microU/ml and plasma glucose was held constant at the fasting level by a variable glucose infusion. Glucose uptake of 6.53 +/- 0.80 mg X kg-1 X min-1 was unchanged by hyperketonemia when compared with an intraindividual control study using saline instead of beta-OH-butyrate infusion (6.26 +/- 0.59 mg X kg-1 X min-1). In studies, in which the degree of metabolic alkalosis accompanying butyrate infusion was mimicked by the continuous administration of bicarbonate, glucose uptake was also unaffected (6.25 +/- 0.45 mg X kg-1 X min-1). Furthermore, hyperketonemia had no effect on basal glucose production or the suppression of hepatic glucose production following hyperinsulinemia. It is concluded that moderate elevations in plasma beta-hydroxy-butyrate do not alter hepatic or peripheral glucose metabolism.
D020155:3-Hydroxybutyric Acid; D000328:Adult; D001639:Bicarbonates / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006885:Hydroxybutyrates / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007657:Ketone Bodies / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D011188:Potassium / Q000097:blood
D001639:Bicarbonates; D001786:Blood Glucose; D006885:Hydroxybutyrates; D007328:Insulin; D007657:Ketone Bodies; D005947:Glucose; D011188:Potassium; D020155:3-Hydroxybutyric Acid