title: Cutaneous insulin reaction resembling acanthosis nigricans.
abstract: We describe a patient who developed hyperkeratotic, verrucous plaques at sites of repeated insulin injections. One similar case has previously been reported. This phenomenon may be an unusual manifestation of the trophic actions of insulin.
mesh_terms: D000052:Acanthosis Nigricans / Q000175:diagnosis*; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced*
chemical_list: D007328:Insulin