Identification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genes.
A serine esterase called granzyme A, which is specifically expressed in cytolytic lymphocytes has been characterized. It is a disulfide-linked dimer and exhibits a trypsin-like specificity cleaving best after Arg. N-terminal sequence analysis revealed that granzyme A is identical to a protease recently predicted from a cloned CTL-specific gene.
D000595:Amino Acid Sequence; D004591:Electrophoresis, Polyacrylamide Gel; D010450:Endopeptidases / Q000097:blood* / Q000235:genetics; D005796:Genes; D053804:Granzymes; D012697:Serine Endopeptidases; D013602:T-Lymphocytes, Cytotoxic / Q000201:enzymology*
D010450:Endopeptidases; D053804:Granzymes; D012697:Serine Endopeptidases