Aggregation of unilamellar lecithin liposomes induced by cyclosporin.
Small unilamellar [14C]lecithin liposomes prepared in the presence of cyclosporin sedimented at 12,000 g. Sepharose 4B gel filtration of the resuspended pellet and supernatant yielded identical peaks consisting of small unilamellar liposomes containing cyclosporin. The column retained 40-50 per cent of 14C-labelled liposomes prepared in the presence of cyclosporin as liposome aggregates.
D003524:Cyclosporins / Q000008:administration & dosage* / Q000378:metabolism; D004337:Drug Carriers; D008081:Liposomes
D003524:Cyclosporins; D004337:Drug Carriers; D008081:Liposomes