Statistical analysis of statural growth following kidney transplantation.
Factors affecting the growth rates of 59 children and adolescents for the first 2 years following kidney transplantation were evaluated. The factors assessed were age at transplantation, renal function, prednisone dosage, donor source, and prior history of transplantation. The observed growth velocity was expressed as the percentage of the growth velocity predicted by bone age. Normal growth (greater than or equal to 80%) was exhibited by 37% of the patients and 22% had accelerated growth (greater than or equal to 100%). The chronological age at transplantation did not correlate significantly with growth when bone age was used as the reference for expected velocity. Males grew better than did females. There was a unique sex/race interaction with black males growing most rapidly. Better renal function, the ability to lower prednisone dosage, alternate day prednisone, and a decreasing diastolic blood pressure were positively correlated with better growth rates after transplantation. Donor source and prior history of transplantation did not significantly influence growth rate.
D000293:Adolescent; D000365:Age Determination by Skeleton; D000367:Age Factors; D001794:Blood Pressure; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000187:drug effects; D006128:Growth; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D012737:Sex Factors; D013997:Time Factors
D011241:Prednisone