title: Simple and rapid GLC method for the determination of orphenadrine in human plasma.
abstract: A rapid and specific method has been developed for the determination of orphenadrine concentration in plasma. It involves a one-step sample preparation using n-hexane/isopropyl alcohol (98:2) extraction, and analysis by gas chromatography on a wide bore capillary column using nitrogen/phosphorus detection. This procedure considerably simplifies previously reported assays and is specific and sensitive enough for the determination of orphenadrine in plasma of patients on chronic therapy.
mesh_terms: D002849:Chromatography, Gas / Q000379:methods*; D006801:Humans; D009966:Orphenadrine / Q000031:analogs & derivatives* / Q000097:blood*
chemical_list: D009966:Orphenadrine; C005834:tofenacin