title: Dose titration in clinical trials. An example using emepronium carrageenate in detrusor instability.
abstract: Seventy-two women with proven detrusor instability completed a novel clinical trial of the new anticholinergic emepronium carrageenate (Cetiprin novum), which allowed for dose titration. The tolerated dose has been shown to correlate with the severity of symptoms. Statistically significant improvement was achieved in symptomatic and urodynamic parameters without serious side effects.
mesh_terms: D000328:Adult; D000368:Aged; D002351:Carrageenan / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D004629:Emepronium / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage*; D014549:Urinary Incontinence / Q000188:drug therapy*; D014563:Urodynamics
chemical_list: D004338:Drug Combinations; D000644:Quaternary Ammonium Compounds; D004629:Emepronium; C046238:emepronium carrageenate; D002351:Carrageenan