Effect of streptozotocin-induced diabetes and insulin treatment on the degradation of hexokinase II in the skeletal muscle of the rat.
The rate of degradation of hexokinase II and the general pool of cytosolic proteins was measured in the skeletal muscle of normal, streptozotocin-diabetic, and insulin-treated streptozotocin-diabetic rats. The rate constant for hexokinase II degradation increases by a factor of 3 in the diabetic as compared with the normal animal. There were analogous alterations observed for the general pool of cytosolic proteins; however, the changes were much more subtle. Insulin treatment restores the increased degradative rate to normal levels in both classes of muscle proteins.
D000818:Animals; D003600:Cytosol / Q000201:enzymology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000201:enzymology; D006593:Hexokinase / Q000378:metabolism*; D007328:Insulin / Q000627:therapeutic use*; D007700:Kinetics; D008297:Male; D008433:Mathematics; D009132:Muscles / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D006593:Hexokinase