An immunological study of a Pb-thionein like protein in rat liver.
Administration of a sublethal dose of lead acetate to rats induced the simultaneous synthesis of a Pb-thionein like protein (Pb-BP) and Zn-thionein in the liver. To determine of the Pb-BP is a species of metallothionein, immunological properties of this protein were investigated. The results indicate that the Pb-BP is cross-reactive with the antibody against rat Zn-thionein II, strongly suggesting that the Pb-BP is a metallothionein.
D000818:Animals; D000906:Antibodies / Q000276:immunology; D000918:Antibody Specificity; D000941:Antigens / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D007158:Immunologic Techniques; D007854:Lead / Q000378:metabolism / Q000494:pharmacology; D008099:Liver / Q000032:analysis* / Q000187:drug effects; D008297:Male; D008668:Metallothionein / Q000032:analysis* / Q000276:immunology / Q000378:metabolism; D009942:Organometallic Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000378:metabolism
D000906:Antibodies; D000941:Antigens; D009942:Organometallic Compounds; D007854:Lead; D008668:Metallothionein; D015032:Zinc; C008261:lead acetate