title: Plasticity in the hypothalamic magnocellular neurosecretory system.
abstract: Over the past decade or so, plasticity has emerged as an important, quantifiable property of the mammalian hypothalamic magnocellular neurosecretory system. This plasticity has turned out to be genuinely related to normal function in the sense that it is a set of responses to physiological stimulation rather than only the sequelae of insult or injury, and it is generally completely reversible. This latter property, of course, distinguishes it further from the plasticity observed after injury. Four features of this magnocellular system that have been shown to display predictable and reversible intercellular plasticity are reviewed: the relationships between neurons and their associated astrocytic glia at various levels (dendritic somatic and terminal) of the magnocellular elements; the extent of terminal and glial contact with the basement lamina in the neurohypophysis; the type and possible efficacy of synaptic input, and the extent of electrotonic coupling among the magnocellular neurons.
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000502:physiology; D006801:Humans; D007395:Interneurons / Q000502:physiology; D009457:Neuroglia / Q000502:physiology; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology; D009490:Neurosecretory Systems / Q000502:physiology*; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D010904:Pituitary Gland, Posterior / Q000502:physiology; D011188:Potassium / Q000378:metabolism; D013495:Supraoptic Nucleus / Q000502:physiology*; D013569:Synapses / Q000502:physiology
chemical_list: D011188:Potassium