Biological activity in vivo of insulin analogues modified in the N-terminal region of the B-chain.
[AlaB5]Insulin as well as a hybrid analogue of insulin and "insulin-like growth factor" (IGF-I), in which the N-terminal amino-acid sequence H-Phe-Val-Asn-Gln- of the B-chain has been replaced by the tripeptide H-Gly-Pro-Glu-of IGF-I, have been prepared by the partial-synthetic route. Their biological activity in vivo has been compared with that of other analogues in rabbits, mice and rats as far as data are available. These rodents respond differently, rats being less sensitive to modifications than rabbits and mice. The results explain unexpected discrepancies discussed in previous papers.
D000595:Amino Acid Sequence; D000818:Animals; D007328:Insulin / Q000031:analogs & derivatives* / Q000502:physiology; D051379:Mice; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship; D013552:Swine
D007328:Insulin