Tiopronin-nephropathy: clinical, pathological, immunological and immunogenetic characteristics.
Nine patients who developed proteinuria while on Tiopronin (a D-Penicillamine-like drug) have been studied. Nephrotic syndrome was observed in six cases. Immunologic analysis revealed a high frequency of ANA positivity and RF seronegativity by the time nephropathy appeared. Six patients were biopsied. Immunofluorescence, electron and light microscopy studies showed: glomerulonephritis with segmental deposits in the mesangium and along the capillary walls in one patient, mesangioprolipherative glomerulonephritis in one case and stage 1 membranous glomerulonephritis in four cases. Immunogenetic typing disclosed a strong association with B35-Cw4 class I antigens.
D000328:Adult; D000368:Aged; D000603:Amino Acids, Sulfur / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D001707:Biopsy, Needle; D002196:Capillaries / Q000648:ultrastructure; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D011507:Proteinuria; D012079:Renal Circulation; D008625:Tiopronin / Q000009:adverse effects* / Q000627:therapeutic use
D000603:Amino Acids, Sulfur; D003176:Complement C3; D003181:Complement C4; D007136:Immunoglobulins; D008625:Tiopronin