title: Antibiotic tetaine--a selective inhibitor of chitin and mannoprotein biosynthesis in Candida albicans.
abstract: The antibiotic tetaine inhibits in Candida albicans the biosynthesis of two important cell wall constituents, chitin and mannoprotein. This effect is a consequence of inactivation of the enzyme glucosamine-6-phosphate synthetase. Due to the lack of glucosamine-6-phosphate the effective secretion of mannoprotein enzymes, acid phosphatase and invertase, by Candida albicans spheroplasts is inhibited. In the presence of tetaine, probably a modified mannoprotein, lacking a branched polymannan, is synthesized. The antibiotic action decreases the viability of Candida albicans cells, especially that of mycelial forms of this fungus.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D002686:Chitin / Q000096:biosynthesis*; D004151:Dipeptides / Q000494:pharmacology; D005656:Fungal Proteins / Q000096:biosynthesis; D005944:Glucosamine / Q000031:analogs & derivatives / Q000378:metabolism; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives*; D005958:Glucosephosphates / Q000378:metabolism; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000037:antagonists & inhibitors; D006023:Glycoproteins / Q000096:biosynthesis*; D008562:Membrane Glycoproteins
chemical_list: D000900:Anti-Bacterial Agents; D004151:Dipeptides; D005656:Fungal Proteins; D005958:Glucosephosphates; D006023:Glycoproteins; D008562:Membrane Glycoproteins; C025363:mannoproteins; D002686:Chitin; C001293:glucosamine 6-phosphate; D019298:Glucose-6-Phosphate; C006674:bacilysin; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); D005944:Glucosamine