title: Experimental Escherichia coli endotoxin-induced sensitisation and abortion in sows.
abstract: Subcutaneous injection of 235 micrograms endotoxin from E coli 08: K87, K88ab into two sows 14 days before the expected farrowing date elicited a toxic shock reaction but the sows recovered and farrowed normally. No reaction was observed in two other sows which had received endotoxin-free 0.9 per cent saline. In a subsequent pregnancy, the same four sows were injected subcutaneously with 23 mg of the same endotoxin preparation. Those which had previously received endotoxin exhibited a severe shock reaction and aborted after 28 and 40 hours, respectively, while the other two sows showed a milder reaction and farrowed normally.
mesh_terms: D000034:Abortion, Veterinary / Q000209:etiology* / Q000382:microbiology; D000818:Animals; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005260:Female; D006968:Hypersensitivity, Delayed / Q000382:microbiology / Q000662:veterinary*; D011247:Pregnancy; D012772:Shock, Septic / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000209:etiology* / Q000382:microbiology
chemical_list: D004731:Endotoxins