[Comparative study of the chemotherapeutic effectiveness of mecillinam, ampicillin and their combination in coli bacillary pyelonephritis in rats].
The chemotherapeutic effect of mecillinam and ampicillin was studied comparatively on rats with hematogenic obturation colibacillary pyelonephritis. The antibiotics were administered intragastrically in a dose of 100 mg/kg for 7 days. The treatment was started 24 hours after infection. When the drugs were used in combination their doses were twice as lower. When used alone mecillinam and ampicillin had a significant effect which was practically the same. A marked increase in the therapeutic effect was observed with the use of the antibiotics in combination: sterilization of the tissues of the affected kidney and prevention of development of macroscopic lesions in it in all the animals.
D000560:Amdinocillin / Q000627:therapeutic use*; D000667:Ampicillin / Q000627:therapeutic use*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004926:Escherichia coli / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D005260:Female; D007668:Kidney / Q000382:microbiology / Q000473:pathology; D011704:Pyelonephritis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D051381:Rats
D000667:Ampicillin; D000560:Amdinocillin
Sravnitel'noe izuchenie khimioterapevticheskoĭ éffektivnosti metsillinama, ampitsillina i ikh kombinatsii pri kolibatsilliarnom pielonefrite u krys.