title: Cefazolin vs moxalactam? A double-blind randomized trial of cephalosporins in head and neck surgery.
abstract: Cefazolin and moxalactam were compared in a prospective randomized double-blind trial of 118 patients undergoing oncologic head and neck surgery. Both antibiotics were given 2 g every four hours for four doses. Five infections were encountered in the cefazolin group (8.5%) and two infections in the moxalactam group (3.4%); this difference was not statistically significant. This assessment does not indicate, however, that the two regimens are equally efficacious.
mesh_terms: D002437:Cefazolin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D009070:Moxalactam / Q000627:therapeutic use*; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D002437:Cefazolin; D009070:Moxalactam