[Detection of endotoxins in radiopharmaceutical preparations--I. Comparison of rabbit hyperthermia after intravenous or intrathecal administration of reference endotoxin preparations].
The rise of the rabbit internal temperature after endotoxin injection is related to the route of administration. A rise of 1.71 +/- 0.411 degrees C is obtained after i.v. injection of 1 ng/kg Escherichia coli 0111.B.4 endotoxin. An increase of 1.93 +/- 0.236 degrees C is obtained after suboccipital intrathecal injection of 0.1 ng/kg of the same endotoxin; with the intrathecal route, the hyperthermia is induced by E. coli endotoxin after a dose ten times lower than with i.v. injection as shown by statistical analysis.
D000818:Animals; D004340:Drug Contamination; D004731:Endotoxins / Q000008:administration & dosage / Q000633:toxicity*; D004926:Escherichia coli; D005334:Fever / Q000139:chemically induced*; D007275:Injections, Intravenous; D007278:Injections, Spinal; D011817:Rabbits; D011868:Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects*; D012015:Reference Standards
D004731:Endotoxins; D011868:Radioisotopes
La recherche des endotoxines dans les préparations radiopharmaceutiques--I. Comparaison de l'hyperthermie du lapin après administration intraveineuse ou intrathécale d'endotoxine de référence.