Metoprolol decreases the amount of halothane required to induce hypotension during general anaesthesia.
A double-blind, randomized and placebo-controlled study was undertaken to assess the effects of metoprolol on controlled hypotension during halothane anaesthesia. Nineteen patients under-going middle ear or nasal septum surgery were studied. The aim was to achieve a 25% reduction of the mean arterial pressure in both groups. Metoprolol was given by mouth on two occasions in the 10-12 h before operation. In the group pretreated with metoprolol the halothane concentration was reduced by 35.5%. The duration of bleeding and its degree were reduced significantly. The time to awakening was shorter and of better quality after pretreatment with metoprolol. Rate-pressure product was less after pretreatment with metoprolol, and rebound hypertension was well controlled.
D000328:Adult; D000762:Anesthesia Recovery Period; D000769:Anesthesia, Inhalation; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004341:Drug Evaluation; D006221:Halothane / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D007023:Hypotension, Controlled; D007431:Intraoperative Complications / Q000517:prevention & control; D008790:Metoprolol / Q000494:pharmacology; D008875:Middle Aged; D011229:Preanesthetic Medication
D008790:Metoprolol; D006221:Halothane