Histaminergic projections from the premammillary and posterior hypothalamic region to the caudate-putamen complex in the rat.
Immunofluorescence, using antibodies to histamine and to histidine decarboxylase, was combined with retrograde axonal tracing by injecting Granular Blue into the caudate-putamen complex. Evidence is presented for the existence of histaminergic as well as non-histaminergic projections from the posterior hypothalamus and the premammillary region to the caudate-putamen complex. The majority of the histaminergic neurons projecting to this brain region are localized in the nuclei caudalis magnocellularis and caudalis magnocellularis postmammillaris. Roughly 20-25% of the histaminergic neurons in these cell groups innervate the caudate-putamen complex.
D000818:Animals; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000166:cytology*; D002452:Cell Count; D005260:Female; D005455:Fluorescent Antibody Technique; D006632:Histamine / Q000032:analysis*; D006640:Histidine Decarboxylase / Q000032:analysis; D007031:Hypothalamus / Q000166:cytology*; D007211:Indoles; D009434:Neural Pathways / Q000032:analysis / Q000166:cytology; D009474:Neurons / Q000032:analysis; D011699:Putamen / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains
D007211:Indoles; C043991:granular blue; D006632:Histamine; D006640:Histidine Decarboxylase