Effects of preoperative glucose-insulin-potassium on myocardial glycogen levels and on complications of mitral valve replacement.
Myocardial glycogen content was increased from a mean of 25.8 +/- 3.7 to 40.3 +/- 4.2 mumol/gm (p less than 0.0001) by an infusion of glucose, insulin, and potassium before mitral valve replacement. Patients who had received such an infusion and who had a higher myocardial glycogen content had a lower incidence of postoperative hypotension, less serious postoperative arrhythmias, and fewer serious complications after elective mitral valve replacement.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006003:Glycogen / Q000032:analysis*; D006350:Heart Valve Prosthesis; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D009206:Myocardium / Q000032:analysis*; D011183:Postoperative Complications / Q000209:etiology*; D011188:Potassium / Q000008:administration & dosage*; D011300:Preoperative Care; D011446:Prospective Studies; D012306:Risk
D007328:Insulin; C030396:glucose-insulin-potassium cardioplegic solution; D006003:Glycogen; D005947:Glucose; D011188:Potassium