Cardiovascular function in obstructive jaundice: experimental observations.
Patients with obstructive jaundice are more susceptible to post-operative shock than are nonjaundiced patients. This paper reviews the presently available experimental information, and concludes that jaundice blunts the contractile response of cardiac and vascular smooth muscle to sympathetic stimulation. Moreover, the experimental studies indicate that altered peripheral catecholamine metabolism may account for these attenuated responses.
D000818:Animals; D001652:Bile Ducts / Q000378:metabolism; D002319:Cardiovascular System / Q000378:metabolism*; D002779:Cholestasis / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007022:Hypotension / Q000209:etiology; D008026:Ligation; D011183:Postoperative Complications; D012769:Shock / Q000209:etiology*