title: [Use of the hypotensive drug guanfacine in the treatment of patients with hypertension].
abstract: The hypotensive effect of guanfacin was evaluated in 39 essentially hypertensive patients aged 18 to 64 years and treated for 2 months. Their central, and peripheral hemodynamics, intracardiac kinetics and some humoral factors responsible for vascular tonicity control were also examined. The drug can be effective in patients with second- and third-stage essential hypertension, with a good hypotensive effect being obvious within 3-5 days of treatment (3 mg daily was the highest dose). In the course of treatment, general left-ventricular pump function returned to normal in 20 patients exhibiting a good hypotensive effect. Within 2 months of treatment, originally high plasma renin activity returned to normal, and the activity of angiotensin-converting enzyme declined.
mesh_terms: D000293:Adolescent; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D016316:Guanfacine; D006146:Guanidines / Q000008:administration & dosage / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D010648:Phenylacetates / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D006146:Guanidines; D010648:Phenylacetates; D016316:Guanfacine
vernacular_title: Primenenie guanfatsina - gipotenzivnogo preparata dlia lecheniia bol'nykh gipertonicheskoĭ bolezn'iu.