title: What's new in transplacental carcinogenesis?
abstract: The discovery that a non-steroidal oestrogen may cause malformations and neoplasia following transplacental administration in man has led to a considerable amount of experimental work on this type of carcinogenesis. In general, there are a number of features which suggest that this is unlikely to be a commonly occurring mode of carcinogenesis in man and the reasons for this are discussed and considered here together with some experimental justification for this position.
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
chemical_list: D002273:Carcinogens