title: B.C.L. and immune response in mice.
abstract: The effects of Korean herbal medicine (B.C.L.) on some parameters of immunological response were studied in mice. B.C.L. pretreatment given either intraperitoneally or subcutaneously in a dose of 0.75 mg/mouse did not significantly inhibit lymphocyte transformation induced by concanavalin A. However, B.C.L. pretreatment in a dose of 2.25 mg/mouse was found to reduce significantly both the plaque-forming cells to sheep red blood cells immunisation as well as total spleen cell population. Thus, B.C.L. pretreatment with a higher dose (2.25 mg/mouse) can selectively depress the humoral immune response. It is unclear, however, whether this action is mediated by the parent compound or its metabolites.
mesh_terms: D000818:Animals; D005260:Female; D006462:Hemolytic Plaque Technique; D007109:Immunity / Q000187:drug effects*; D007166:Immunosuppressive Agents; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D008211:Lymphocyte Cooperation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D010946:Plants, Medicinal; D013154:Spleen / Q000187:drug effects*
chemical_list: D007166:Immunosuppressive Agents