[Pharmacokinetic, biochemical and histological study of the carbamazepine-josamycin interaction in the rat following chronic administration].
The determination of possible modifications of pharmacokinetic parameters of carbamazepine by josamycin in an experimental study after chronic administration of the drugs in the rat was undertaken to assay, or not, the enzymatic inhibition hypothesis which is supported in human clinical studies. Our data do not show any alteration in the Cmax, Tmax and AUC parameters of carbamazepine (total and unbound fraction) in case of conjunction with josamycin, but an earlier increase of plasmatic concentrations. The biochemical parameters are not modified, but a significant decrease of total bilirubin compared with controls and carbamazepine alone. The histological study does not show any liver lesion.
D000818:Animals; D002220:Carbamazepine / Q000097:blood / Q000494:pharmacology*; D004347:Drug Interactions; D007700:Kinetics; D007933:Leucomycins / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007933:Leucomycins; D002220:Carbamazepine
Etude pharmacocinétique, biochimique et histologique de l'interaction carbamazépine-josamycine chez le rat aprés administration chronique.