[Effect of the proteolysis of low-density serum lipoproteins on their interaction with macrophages].
125I-labelled human serum low density lipoproteins (LDL) were incubated with cultured mouse peritoneal macrophages at 37 degrees C, with the following study of cellular uptake and 125I-LDL degradation by measuring the content of TCA-soluble products of LDL hydrolysis in the cultural medium. It was shown that limited pepsin proteolysis of LDL (10%) led to a more effective LDL uptake and degradation by macrophages. The data suggest that enzyme-induced modification of LDL may increase their atherogenicity.
D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D010447:Peptide Hydrolases / Q000378:metabolism*; D010529:Peritoneal Cavity / Q000166:cytology
D008077:Lipoproteins, LDL; D010447:Peptide Hydrolases
Vliianie proteoliza syvorotochnykh lipoproteidov nizkoĭ plotnosti na ikh vzaimodeĭstvie s makrofagami.