Effect of saccharin on the meiotic division of Saccharomyces cerevisiae.
The effect of saccharin on the occurrence of meiotic diploid and disomic products in Saccharomyces cerevisiae was investigated. It was found that this substance inhibits the sporulation process in a dose-dependent manner, is ineffectual on recombination frequency, and slightly increases the occurrence of diploid and disomic meiotic products. It is demonstrated that the formation of diploid meiotic products is a consequence of random nuclear fusions at the end of the meiotic process or of endomitosis preceding meiosis.
D008540:Meiosis / Q000187:drug effects; D012439:Saccharin / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000502:physiology; D013172:Spores, Fungal
D012439:Saccharin