Antigenic profiles of human, bovine and canine articular chondrocytes.
Human, bovine and canine articular chondrocytes have been shown to bear cartilage matrix, chondrocyte-specific and histocompatibility antigens. These cell-surface antigens of chondrocytes were demonstrated both simultaneously and separately either by complement-mediated cytotoxicity or by immunohistochemical reactions. The chondrocyte-specific antigens involve subsets of species-common and species-specific determinants, which are also present on the surfaces of rib and laryngeal chondrocytes. In addition to these antigens, human and calf articular chondrocytes also express unique cell-surface components that are capable of producing a blastogenic stimulation of autologous T-lymphocytes in vitro. These putative autoantigens segregated from lymphocytes in vivo could be released in trauma and in inflammatory joint diseases triggering the immune system of the host.
D000818:Animals; D002356:Cartilage / Q000166:cytology / Q000276:immunology*; D002358:Cartilage, Articular / Q000166:cytology / Q000276:immunology; D002417:Cattle / Q000276:immunology*; D003429:Cross Reactions; D004285:Dogs / Q000276:immunology*; D005109:Extracellular Matrix / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D007106:Immune Sera; D007231:Infant, Newborn; D007830:Larynx / Q000166:cytology / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D013045:Species Specificity
D006649:Histocompatibility Antigens; D007106:Immune Sera