title: High frequency positive pressure ventilation in experimental meconium aspiration syndrome.
abstract: To compare high frequency positive pressure ventilation (HFV) to conventional ventilation (CV) in experimental meconium aspiration syndrome (MAS) adult rabbits were randomly assigned to one of four groups: sham (G1) n = 10, control (G2) n = 12, CV (G3) n = 6, and HFV (G4) n = 6. All animals were stabilized on an FI O2 of 0.70 after a tracheostomy and arterial line were placed. The alveolar-arterial oxygen difference (A-aDO2) was calculated for each blood gas measurement and mean airway pressure (MAP) measured in CV and HFV at the time of each blood gas. Human meconium (2 ml/kg of 25% solution) was instilled intratracheally (MI) in groups 2-4. Group 3 was then placed on conventional ventilation with a rate of 40 BPM while Group 4 with a rate of 400 BPM. Analysis of variance was used to compare A-aDO2 and MAP. There was no significant difference between group 4 and group 2, while there was a significant difference between group 3 and groups 2 and 4. Sustained inflation of 25 cm H2O as used for 20 seconds was used before HFV in a fifth group (n = 6) that was added to the study and was otherwise identical to HFV. There was no significant difference between the fifth group and group 2 or group 4. Our findings indicate HFV is not efficacious in experimental MAS whether or not sustained inflation is used.
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy*; D001239:Inhalation; D007385:Intermittent Positive-Pressure Ventilation; D008171:Lung Diseases / Q000503:physiopathology / Q000628:therapy*; D008470:Meconium / Q000502:physiology*; D010100:Oxygen / Q000378:metabolism; D011175:Positive-Pressure Respiration; D011817:Rabbits; D013577:Syndrome
chemical_list: D010100:Oxygen