title: The influence of androgen administration on the structure and function of the brain-pituitary-gonad axis of sexually immature platyfish, Xiphophorus maculatus.
abstract: This report demonstrates that the administration of testosterone (T) or 11-ketotestosterone (11-KT) to sexually immature (8 wks old) male platyfish (Xiphophorus maculatus) of early- and late-maturing genotypes affects the synthesis and/or release of luteinizing hormone-releasing hormone (LHRH), as assessed by immunocytochemical evaluation, increases the number and activity of pituitary gonadotropes, stimulates the production of sperm and, thus, advances the age of sexual maturation over that dictated by the genome. We also show that 11-KT and T affect different LHRH-containing centers in the brain and have differential effects on rate and degree of sexual maturation, regardless of whether the hormones are administered to early or late-maturing genotypes.
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D003532:Cyprinodontiformes; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D012741:Sexual Maturation / Q000187:drug effects*; D013737:Testis / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; C003600:11-ketotestosterone