title: Clinical pharmacologic implications in diuretic selection.
abstract: Logical and comprehensive diuretic therapy is based on a sound knowledge of renal physiologic principles. Knowledge of the sites within the nephron at which the currently available diuretics work and their modes of action provide the clinician with a basis upon which to arrive at therapeutic decisions. True diuretic resistance is uncommon, but when it occurs, sequential nephron blockade can frequently reverse the refractoriness initially exhibited by the patient.
mesh_terms: D001639:Bicarbonates / Q000378:metabolism; D004232:Diuretics / Q000494:pharmacology*; D005919:Glomerular Filtration Rate; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D007671:Kidney Concentrating Ability / Q000187:drug effects; D007686:Kidney Tubules, Distal / Q000187:drug effects / Q000502:physiology; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000502:physiology; D008138:Loop of Henle / Q000187:drug effects / Q000502:physiology; D010710:Phosphates / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D001639:Bicarbonates; D004232:Diuretics; D010710:Phosphates; D012964:Sodium