[Partial somatotropin deficiency in a case of chronic renal insufficiency with renal transplantation. Efficacy of treatment with human growth hormone].
The authors report a case of chronic renal failure with a -4 SD growth retardation. The patient underwent dialysis and then transplantation. Investigations to determine somatotropin deficiency showed dissociated results of 4 stimulation tests: 2 normal responses and 2 low responses. Treatment with human growth hormone (10 mg/kg/year) induced a dramatic acceleration of the growth velocity, which increased from 2 to 7 cm/year. After 18 months, the gain in height was 10 cm. Data submitted by several authors on Cushing's disease and the interrelations cortisone/somatotropin secretion suggest that continuous and/or alternate corticotherapy may be the cause of this partial somatotropin deficiency.
D000293:Adolescent; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy / Q000209:etiology*; D013006:Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000503:physiopathology; D016030:Kidney Transplantation
D013006:Growth Hormone
Déficit somatotrope partiel dans un cas d'insuffisance rénale chronique avec transplantation rénale. Efficacité du traitement par l'hormone de croissance humaine.