Effect of indomethacin treatment on prostaglandin excretion and tissue phospholipid fatty acid composition in rats bearing mammotropic pituitary tumor, MtT-F4.
The hypothesis that hormonal changes induced by the mammotropic pituitary tumor, MtT-F4, might accelerate the conversion of n-6 fatty acids to prostaglandins, resulting in a partial depletion of n-6 fatty acids was examined. In tumor-bearing rats, the administration of indomethacin induced a 50% reduction of the urinary prostaglandin levels, but exerted no significant effect on the fatty acid composition of the tissue phospholipids. It is concluded that the observed depletion of n-6 fatty acids in tumor-bearing rats is not caused by an increased production of prostaglandins.
D015121:6-Ketoprostaglandin F1 alpha / Q000031:analogs & derivatives / Q000652:urine; D000818:Animals; D011464:Epoprostenol / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis*; D007213:Indomethacin / Q000494:pharmacology*; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism* / Q000652:urine; D010743:Phospholipids / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000652:urine; D011453:Prostaglandins / Q000652:urine*; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution
D005227:Fatty Acids; D010743:Phospholipids; D011453:Prostaglandins; D015121:6-Ketoprostaglandin F1 alpha; C028290:2,3-dinor-6-ketoprostaglandin F1alpha; D011464:Epoprostenol; D007213:Indomethacin