[Stimulation of phagocytic function by factors inhibiting leukocyte and macrophage migration in humans].
Fractions containing macrophage migration inhibition factor (MIF) and leucocyte migration inhibition factor (LIF) were obtained using Sephadex G-200 filtration from supernatant fluids of human lymphocyte cultures stimulated by PHA. The fractions were tested for the ability to affect migration and phagocytic activity of target cells. Peripheral blood leucocyte migration capacity was inhibited by the fraction with the molecular mass of 60,000-70,000 D (LIF), while migration activity of mouse peritoneal exudate cells was suppressed by the fraction with the molecular mass of 20,000-30,000 D (MIF). MIF- and LIF-containing fractions increased almost three-fold Fc-receptor-mediated phagocytic activity of neutrophils.
D006801:Humans; D066298:In Vitro Techniques; D007961:Leukocyte Migration-Inhibitory Factors / Q000494:pharmacology*; D008222:Lymphokines / Q000494:pharmacology*; D008263:Macrophage Migration-Inhibitory Factors / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects*; D013268:Stimulation, Chemical
D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; D008263:Macrophage Migration-Inhibitory Factors
Stimuliatsiia fagotsitarnoĭ funktsii faktorami, ugnetaiushchimi migratsiiu leĭkotsitov i makrofagov u cheloveka.