title: Selective hepatic vagotomy does not prevent compensatory feeding in response to body weight changes.
abstract: The effects of selective hepatic vagotomy on compensatory adjustments of feeding in response to experimentally induced changes in body weight were investigated in rats. Repeated injections of slow-acting insulin increased food intake and body weight in vagotomized as well as in sham-vagotomized rats. When the treatment was stopped, the rats of both surgical groups displayed a compensatory hypophagia of similar magnitude and body weight returned to preinjection levels. In turn, after 7 days of restricted feeding (5 g/day) with a concomitant loss of body weight, rats became hyperphagic and body weight approached the normal level. Again, the feeding responses or body weight changes did not differ between vagotomized and sham-vagotomized rats. The results demonstrate that selective hepatic vagotomy does not disrupt the putative feedback-loop between body weight and feeding, and raise questions concerning the role of the liver in the lipostatic control of food intake.
mesh_terms: D000818:Animals; D001835:Body Weight; D005215:Fasting; D005247:Feeding Behavior / Q000502:physiology*; D007328:Insulin / Q000494:pharmacology; D050356:Lipid Metabolism; D008099:Liver / Q000294:innervation*; D008297:Male; D009765:Obesity / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D007328:Insulin