title: Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties.
abstract: A review of physicochemical and analytical properties of anthracycline antitumour agents is presented. The following subjects are discussed: protolytic equilibria, partition and partition coefficients, self-association, adsorptive properties, metal complexation, spectroscopy and chromatography. Furthermore, the stability of anthracyclines in solutions, in pharmaceutical preparations and in biological media is discussed.
mesh_terms: D000327:Adsorption; D000903:Antibiotics, Antineoplastic / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D008670:Metals / Q000032:analysis; D009279:Naphthacenes / Q000032:analysis; D012995:Solubility; D013053:Spectrophotometry
chemical_list: D000903:Antibiotics, Antineoplastic; D008670:Metals; D009279:Naphthacenes