Methylprednisolone treatment in aplastic anaemia.
Twenty patients with aplastic anaemia were treated with a short term bolus of methylprednisolone. Seven patients were refractory to anabolic steroids and were observed in very long follow-up periods of 14-104 months. Thirteen patients had never been treated. The latter group also received anabolic steroids. Five out of 20 patients responded to the treatment while the remaining patients did not or died. Responders among patients refractory to anabolic steroids had shorter duration of disease compared to non-responders. No recurrence of aplasia was observed in all responders.
D000293:Adolescent; D000328:Adult; D000368:Aged; D045930:Anabolic Agents / Q000627:therapeutic use; D000741:Anemia, Aplastic / Q000188:drug therapy*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged
D045930:Anabolic Agents; D008775:Methylprednisolone