Vasopressin release after enhanced serotonergic transmission is not due to activation of the peripheral renin-angiotensin system.
Pharmacological enhancement of 5-hydroxytryptamine (5-HT) transmission increases plasma vasopressin in rats. To investigate whether this effect is mediated through activation of the peripheral renin-angiotensin system, plasma vasopressin concentrations were measured after 5-HT activation in rats with lesions of the subfornical organ or pretreated with saralasin. The results show that the 5-HT-induced elevation of vasopressin is not due to activation of the peripheral renin-angiotensin system.
D000818:Animals; D008297:Male; D009490:Neurosecretory Systems / Q000502:physiology*; D011814:Quipazine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects; D012504:Saralasin / Q000494:pharmacology*; D012701:Serotonin / Q000502:physiology*; D013356:Subfornical Organ / Q000502:physiology*; D014667:Vasopressins / Q000097:blood / Q000378:metabolism*; D010133:p-Chloroamphetamine / Q000494:pharmacology
D014667:Vasopressins; D012701:Serotonin; D011814:Quipazine; D010133:p-Chloroamphetamine; D012083:Renin; D012504:Saralasin