title: Absorption of anticancer drugs through bladder epithelium.
abstract: Fundamental and clinical evaluations of ten anticancer drugs were performed. The required qualities of an anticancer drug ideal for bladder instillation therapy are thought to be as follows: (1) a high sensitivity for bladder tumor cells; (2) a pKa which provides a high percentage of nonionized molecules in a pH 6-7 solution; (3) a log P in the range from -0.4 to -1.2 or from -7.5 to -8.0; and (4) a molecular weight over 200.
mesh_terms: D000042:Absorption; D000632:Aminopyrine / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D004396:Coloring Agents / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D007474:Ion Exchange; D008970:Molecular Weight; D012995:Solubility; D013419:Sulfamethizole / Q000378:metabolism; D001743:Urinary Bladder / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004396:Coloring Agents; D000632:Aminopyrine; D013419:Sulfamethizole