Immunocytochemical study of glutathione peroxidase in normal rat kidney.
In the normal rat kidney, immunohistochemical localization of glutathione peroxidase (GSH-Po) was mainly in the proximal tubules (PTs), where the proximal portions (S1 + S2) were more intensely stained than the distal portion (S3). Immunocytochemically, GSH-Po was localized in cytosol including the core of microvilli and lysosomes of the epithelial cells in the PTs. Since albumin and IgG were not found in cytosol, it is suggested that cytosolic GSH-Po may be generated in situ, but is not derived from the serum.
D000418:Albumins / Q000032:analysis; D000818:Animals; D005979:Glutathione Peroxidase / Q000032:analysis*; D006651:Histocytochemistry; D007074:Immunoglobulin G / Q000032:analysis; D007158:Immunologic Techniques; D007668:Kidney / Q000201:enzymology*; D007687:Kidney Tubules, Proximal / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000418:Albumins; D007074:Immunoglobulin G; D005979:Glutathione Peroxidase