Mutagenic activity of the dacarbazine analog p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt in bacterial cells.
The mutagenic activity of the antimetastatic agent p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt (DM-COOK) was studied in procaryotic cells and compared with that of dacarbazine (DTIC) which is clinically used in the management of human neoplasms. The results indicated that DM-COOK has a very low mutagenic activity on the Salmonella typhimurium strains tested, while it is more effective in inducing trp+ revertants in E. coli B strains. The magnitude of these effects was always less pronounced than that displayed by DTIC. The mutagenic activity of DM-COOK appeared to be independent from the addition of a metabolic activating system and had a different pattern from that displayed by MM-COOK. It is therefore unlikely that DM-COOK acts through conversion into the monomethyl derivative.
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000633:toxicity; D001711:Biotransformation; D003606:Dacarbazine / Q000633:toxicity*; D004926:Escherichia coli / Q000187:drug effects; D008745:Methylation; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship; D014226:Triazenes / Q000378:metabolism / Q000633:toxicity*
D000970:Antineoplastic Agents; D009153:Mutagens; D014226:Triazenes; C030838:1-(4-carboxyphenyl)-3,3-dimethyltriazene; D003606:Dacarbazine