Detection of pancreas pretumoral stage by means of organ transplantation.
Syrian golden hamsters were treated at monthly intervals for three months with N-nitrosobis (2-oxopropyl) amine (BOP) at doses of 20 mg/kg. During the treatment program individual pancreases were analysed by histology and transplanted into syngeneic recipients. Within the first 20 weeks following BOP administration, only a few alterations in the acinar cells were detected histologically. Nevertheless, pancreases taken as early as 10 weeks following the initiation of the chemical treatment produced local tumors at the site of subcutaneous implantation. Tumors thus obtained by graft were noted to be carcinomas of ductal type. Organ transplantation was thus observed to be a good method of detecting early neoplastic transformations in the pancreas which were not seen by conventional histology.
D000818:Animals; D006224:Cricetinae; D008647:Mesocricetus; D009602:Nitrosamines; D016035:Pancreas Transplantation; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000175:diagnosis*; D011230:Precancerous Conditions / Q000139:chemically induced / Q000175:diagnosis*; D013997:Time Factors
D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine