Influence of the iron chelating agent desferrioxamine on two rat inflammatory models.
The carrageenin rat paw edema was dose-dependently inhibited by i.v. and i.m. administration of desferrioxamine, a specific iron chelating agent. Therefore, iron-catalyzed formation of free radicals might be involved in this acute inflammatory reaction. In contrast, no antiinflammatory activity of desferrioxamine could be seen in rat adjuvant arthritis, a model of subacute and chronic inflammation.
D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy; D002351:Carrageenan; D003676:Deferoxamine / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy; D007249:Inflammation / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
D002351:Carrageenan; D003676:Deferoxamine