[Changes in the level of Krebs cycle metabolites in the brain tissue in the hypoglycemic nervous syndrome].
Different levels of pyruvate, citrate and alpha-ketoglutarate were investigated in the brain tissue of white rats exposed to insulin-induced coma or in various periods following its glucose-cutting. The emergence of pronounced hypoglycemic nervous disorders was followed by a significant decrease in the content of all mentioned acids. Glucose arrest of insulin-caused coma took place in the presence of inactive initial stages of Krebs cycle (citrate synthesis). Restoration of hypoglycemia-affected brain functions had no correlation with the activated citrate synthesis. The levels of citrate and alpha-ketoglutarate normalized 15 minutes after glucose injection and the pyruvate level augmented 30 minutes after the drug administration. It was suggested that the glucose arresting effect demonstrated in insulin coma was conditioned by transformations in glucose carbon lattice regarding pyruvate carboxylising into oxalacetate with further inclusion into brain amino acids and peptides.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002952:Citric Acid Cycle / Q000187:drug effects; D005947:Glucose / Q000627:therapeutic use; D007003:Hypoglycemia / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D051381:Rats; D013577:Syndrome; D013997:Time Factors
D007328:Insulin; D005947:Glucose
Izmeneniia urovnia nekotorykh metabolitov tsikla Krebsa v tkani golovnogo mozga pri gipoglikemicheskom nervnom sindrome.