Improvement of aortocoronary bypass patency by antiplatelet drug administration. Preliminary communication.
Patients with aortocoronary bypass whose peroperatively measured blood flow amounted to 40 ml/min or less were divided into two groups. The treated group was from postoperative day 0 given 2 X 500 mg acetylsalicylic acid and 3 X 75 mg dipyridamole per day; the control group was without this medication. One month and one year after surgery the patients were examined by coronarography. The first follow-up examination revealed in the treated group 34 patent and 7 occluded bypasses, in the control group 17 patent and 20 occluded bypasses. On late follow-up examination there were in the treated group 24 patent and 13 occluded and in the control group 8 patent and 30 occluded bypasses (p less than 0.001).
D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects*; D002986:Clinical Trials as Topic; D001026:Coronary Artery Bypass; D004176:Dipyridamole / Q000494:pharmacology / Q000627:therapeutic use; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000517:prevention & control*; D006801:Humans
D004176:Dipyridamole; D001241:Aspirin