title: Third generation cephalosporin antibiotics in surgical practice.
abstract: The new third generation cephalosporins have a significantly greater spectrum of action against gram-negative bacteria likely to be encountered in surgical infections. This expanded spectrum may permit these drugs to be used in place of combination therapy in patients with polymicrobial infections; however, current evidence does not indicate superior results with these agents over earlier generation choices for surgical prophylaxis. The toxicity profile of these drugs warrants close monitoring for serious complications.
mesh_terms: D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002493:Central Nervous System Diseases / Q000188:drug therapy; D002511:Cephalosporins / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D055598:Chemical Phenomena; D002621:Chemistry; D002764:Cholecystitis / Q000188:drug therapy; D002986:Clinical Trials as Topic; D003428:Cross Infection / Q000188:drug therapy; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy; D006801:Humans; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D002511:Cephalosporins