[Optimizing the composition of the medium for the biosynthesis of antibiotic, proteases and pigments by the mycophilic fungus Hypomyces rosellus using a mathematical experimental design method].
Regulation of protease and pigment production in Hypomyces rosellus by the medium components was easier than that of antibiotic production. Medium was developed. The activity of exoproteases and pigment with the use of this medium increased up to 385-800 PU/ml and 0.68-0.83 arbitrary units, respectively. The level of the antibiotic biosynthesis was insignificant.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D003470:Culture Media / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006999:Hypocreales / Q000378:metabolism*; D008433:Mathematics; D008722:Methods; D010447:Peptide Hydrolases / Q000096:biosynthesis*; D010860:Pigments, Biological / Q000096:biosynthesis*; D012107:Research Design
D000900:Anti-Bacterial Agents; D003470:Culture Media; D010860:Pigments, Biological; D010447:Peptide Hydrolases
Optimizatsiia sostava sredy dlia biosinteza antibiotika, proteaz i pigmentov mikofil'nym gribom Hypomyces rosellus s pomoshch'iu metoda matematicheskogo planirovaniia ékpserimenta.