A comparison of fine needle aspiration cytology and tru-cut tissue biopsy in the diagnosis of acute renal allograft rejection.
Simultaneous Tru-cut biopsies and fine needle aspirations (FNAs) performed over a 2-year period on patients following renal transplantation were assessed by independent pathologists. When there was histological evidence of rejection, FNAs also demonstrated cellular features of rejection in 83% of cases, and this increased to 92% with repeated sampling. The presence of monocytes and histiocytes in FNAs correlated with vascular features of rejection on biopsy and failure to reverse the rejection process with steroids.
D001706:Biopsy / Q000379:methods*; D001707:Biopsy, Needle / Q000009:adverse effects / Q000295:instrumentation; D005188:False Negative Reactions; D005189:False Positive Reactions; D006084:Graft Rejection; D006417:Hematuria / Q000209:etiology; D006644:Histiocytes; D006801:Humans; D007668:Kidney / Q000473:pathology*; D016030:Kidney Transplantation; D009000:Monocytes