Does nifedipine affect the diurnal variation of asthma in children?
Diurnal variations in airway caliber and in bronchial reactivity have been described. The mechanisms underlying these variations are not known. The hypothesis that these variations can be diminished by calcium channel blockers was tested by giving 22 asthmatic children 10 mg of nifedipine or identical placebo three times a day for 4 weeks in a double-blind, randomized, crossover-designed study. Treatment with nifedipine did not diminish the diurnal variations in airway caliber, judged from peak expiratory flow rates, or in bronchial reactivity, judged from bronchodilator responsiveness. Group mean amplitude of the diurnal variation in airway caliber was 10.5% on nifedipine and 10.6% on placebo. Group mean amplitude of the diurnal variation in bronchodilator responsiveness was 75.4% on nifedipine and 69.5% on placebo. There were no differences in mean peak expiratory flow rate between nifedipine and placebo periods. This study did not find any evidence to support the hypothesis that the diurnal variations in airway caliber and in bronchial reactivity can be diminished by calcium channel blockers.
D000293:Adolescent; D000420:Albuterol / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D002648:Child; D002940:Circadian Rhythm / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010366:Peak Expiratory Flow Rate; D011897:Random Allocation; D013806:Theophylline / Q000627:therapeutic use
D013806:Theophylline; D009543:Nifedipine; D000420:Albuterol