[HLA antigens and different clinical forms of 21-hydroxylase deficiency in the French population].
HLA associations with 21-OH deficiency were studied on respectively 109 and 60 congenital and late onset French index cases. Significant negative associations were found with antigens B8: congenital forms; B5, DR3: late onset. Significant positive associations were observed with A3, Bw47 (A3 Cw6 Bw47 DR7): congenital forms; B40: salt-wasting form; B5: simple virilizing form; Aw33, B14, DR1, DR2, DRw6 (Aw33 B14 DR1): late onset form. Among late onset patients not bearing B14 antigens significant positive associations were observed with B12 and B35.
D000312:Adrenal Hyperplasia, Congenital / Q000235:genetics; D000483:Alleles; D003937:Diagnosis, Differential; D005602:France; D006680:HLA Antigens / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008285:Major Histocompatibility Complex; D009154:Mutation; D010375:Pedigree; D011627:Puberty; D013250:Steroid Hydroxylases / Q000172:deficiency*
D006680:HLA Antigens; D013250:Steroid Hydroxylases
Les antigènes HLA et les différentes formes cliniques du déficit en 21-hydroxylase dans la population française.