Increased survival with calcium antagonists in antibiotic-treated bacteremia.
This study was done to test the effectiveness of calcium antagonists on survival in a bacteremic model. Swiss albino mice were injected intraperitoneally with live Escherichia coli at an LD90 dose. When antibiotic treatment was delayed for 3 hr after E coli challenge, there was a mortality range of 30-50% for the gentamicin-treated mice and 40-60% for the cefoxitin-treated mice. A calcium antagonist, either nifedipine or verapamil, was added to this model in different dosages and at different time intervals. Nifedipine yielded a significantly lower mortality both with gentamicin and with cefoxitin. Verapamil did not affect mortality with cefoxitin but did improve survival with gentamicin. Effective dosages occur within a narrow range. The results are encouraging and call for further studies with calcium antagonists to ascertain their prospective usefulness as additives to septic shock treatment.
D000818:Animals; D002440:Cefoxitin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000401:mortality; D005839:Gentamicins / Q000627:therapeutic use*; D051379:Mice; D009543:Nifedipine / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy* / Q000401:mortality; D013997:Time Factors; D014700:Verapamil / Q000627:therapeutic use*
D005839:Gentamicins; D002440:Cefoxitin; D014700:Verapamil; D009543:Nifedipine