The "second set" phenomenon as first shown in skin allografts. An historical case which shows also the behaviour of cell free collagen.
A 2-year-old girl had granulating areas on her abdomen and thigh following burns. On these were placed two "sets" of homografts from her father at an interval of 13 days. The first set showed extensive growth in all directions, the second set showed little or none. Between dressings on the 23rd and 26th day after the first set was applied (10 and 13 days after applying the second set) all the epithelium of both sets disappeared. This strongly suggested that a reaction to the father's epithelium had reached an intensity where it destroyed all "homograft" epithelium on the body. The collagenous ghosts of the homografts remained, became grown over by host epithelium and remained visible below it until the end of the observation period of 2 months.
D002056:Burns / Q000601:surgery*; D002675:Child, Preschool; D003094:Collagen / Q000276:immunology; D004848:Epithelium / Q000276:immunology; D005260:Female; D006084:Graft Rejection; D006801:Humans; D012867:Skin / Q000276:immunology; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D003094:Collagen