Thermal death potentiation by amphotericin B in Cryptococcus neoformans and its dependence on pre-incubation temperature.
Thermal death of Cryptococcus neoformans in the presence of amphotericin B was strongly dependent upon the temperature of pre-incubation. The entropy coefficient, that is, the increase in entropy of activation of thermal death per square unit concentration of the drug in the medium, was 35 times higher after pre-incubation at 25 degrees C than at 39 degrees C. This means that C. neoformans cells grown at lower temperatures were much more sensitive to the temperature-dependent fungicidal effect of amphotericin B.
D000666:Amphotericin B / Q000494:pharmacology*; D003454:Cryptococcus / Q000254:growth & development*; D003455:Cryptococcus neoformans / Q000187:drug effects / Q000254:growth & development*; D013696:Temperature
D000666:Amphotericin B