Antibiotic prophylaxis in cesarean section. Comparison of intrauterine lavage and intravenous administration.
Intrauterine irrigation with a cefazolin solution at cesarean section was compared with intravenous cefazolin administration for prophylaxis against post-cesarean-section endomyometritis in a randomized, controlled, prospective fashion. There were no statistically significant differences in the incidence of infection between the lavage and intravenous groups. The incidence of endomyometritis was 37% in the lavage group and 29% in the intravenous (P = NS). Intrauterine cefazolin lavage is safe, effective, time saving and more cost effective than intravenous cefazolin in preventing post-cesarean-section endomyometritis.
D000328:Adult; D002437:Cefazolin / Q000008:administration & dosage* / Q000627:therapeutic use; D002585:Cesarean Section; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D011247:Pregnancy; D013530:Surgical Wound Infection / Q000517:prevention & control*; D007507:Therapeutic Irrigation; D014599:Uterus
D002437:Cefazolin