Association of the heat shock protein hsp90 with steroid hormone receptors and tyrosine kinase oncogene products.
Monospecific, polyclonal rabbit antibody raised against the 90-kd non-hormone binding component of molybdate-stabilized steroid hormone receptor specifically recognises the 90-kd molecular weight heat shock protein (hsp 90) in mink cell extracts. Partial proteolytic digestion experiments indicate that this protein is identical to the 90-kd phosphoprotein found in a highly stable complex with the protein products of at least three members of the tyrosine kinase family of oncogenes (src, fes, fgr).
D000818:Animals; D000918:Antibody Specificity; D002460:Cell Line; D006360:Heat-Shock Proteins / Q000276:immunology / Q000378:metabolism*; D007158:Immunologic Techniques; D046911:Macromolecular Substances; D008907:Mink; D010750:Phosphoproteins / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism*
D006360:Heat-Shock Proteins; D046911:Macromolecular Substances; D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; D011980:Receptors, Progesterone; D011987:Receptors, Steroid; D011505:Protein-Tyrosine Kinases