Ketoconazole and flucytosine alone and in combination against Candida spp. in a neutropenic site in rabbits.
Ketoconazole and flucytosine were administered alone and in combination for ten days to rabbits with four candida isolates growing in subcutaneously implanted semipermeable chambers. The peak concentrations of ketoconazole in serum and in the chamber were 20.3 and 3.8 mg/l, respectively, and the concentrations of flucytosine 47.7 and 37.3 mg/l, respectively. The two drugs combined resulted in better fungistatic activity than either drug alone against all four isolates. Correlation of efficacy in the rabbit model with in-vitro MICs was good for flucytosine, but poor for ketoconazole.
D000818:Animals; D002175:Candida / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005437:Flucytosine / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D007654:Ketoconazole / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D009503:Neutropenia; D011817:Rabbits
D005437:Flucytosine; D007654:Ketoconazole