Thermic effect of medium-chain and long-chain triglycerides in man.
The thermic effects of 400 kcal meals of medium-chain triglycerides (MCT) and long-chain triglycerides (LCT) were compared in seven healthy men. Metabolic rate was measured before the meals and for 6 h after the meals by indirect calorimetry. Mean postprandial oxygen consumption was 12% higher than basal oxygen consumption after the MCT meal but was only 4% higher than the basal oxygen consumption after the LCT meal. There was a 25-fold increase in plasma beta-hydroxybutyrate concentration and a slight increase in serum insulin concentration after MCT ingestion but not after LCT ingestion. Plasma triglyceride concentrations increased 68% after the LCT meal and did not change after the MCT meal. These data raise the possibility that long-term substitution of MCT for LCT would produce weight loss if energy intake remained constant.
D020155:3-Hydroxybutyric Acid; D000293:Adolescent; D000328:Adult; D001833:Body Temperature Regulation / Q000187:drug effects*; D002153:Calorimetry, Indirect; D004041:Dietary Fats / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D005990:Glycerol / Q000097:blood; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D014280:Triglycerides / Q000097:blood / Q000494:pharmacology*
D004041:Dietary Fats; D006885:Hydroxybutyrates; D007328:Insulin; D014280:Triglycerides; D005990:Glycerol; D020155:3-Hydroxybutyric Acid