title: The genetic basis of resistance and sensitivity to the meiotic drive gene D in the mosquito Aedes aegypti L.
abstract: A study has been made on the genetic basis of meiotic drive at the Distorter (D) locus which, in coupling with the male-determining gene (or region) M on the Y chromosome, causes production of excess male progeny. Its effect is regulated by the sensitivity/resistance of the X chromosome. This study demonstrates that there are two major loci controlling resistance/sensitivity to MD: (1) the m gene (or region) on the X chromosome (allelic with M) which may be either mR or mS (resistant or sensitive), (2) the t (tolerance) gene (or genes) which recombines with m and, if present, largely counteracts the effect of mS. There is also evidence that MD itself is capable of limited adaptation. The conclusions were derived from using MD males of the T30 or ACCRA strains (from Trinidad and Ghana respectively). The work involved the use of the CHIPEI and RED strains with sensitive X chromosomes, the latter also carrying the t (tolerance) gene which is linked to re (red eye) and m (the sex-determining locus or region) but recombines with both. The implications of these findings for using MD as a method of population control are discussed.
mesh_terms: D000330:Aedes / Q000235:genetics*; D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D005796:Genes; D005838:Genotype; D008297:Male; D008540:Meiosis; D010641:Phenotype; D012732:Sex Determination Analysis; D012744:Sex Ratio; D014960:X Chromosome; D014998:Y Chromosome