H-2 modulation of aryl hydrocarbon hydroxylase induction and the mutagenicity of benzo(a)pyrene after 3-methylcholanthrene treatment.
All strains except the DBA/2J, B10.S and B10.RIII exhibited an increase in hepatic cytochrome P-450 levels following MC treatment; furthermore, the P-450 response of the B10.D2 strains was greater than that seen in the B10 and B6 strains. MC treatment increased BP metabolism in all congenic strains relative to their corn oil controls. Both relative and absolute changes in AHH activity were higher in the B10.D2 than the B6 or B10 reference strains. All congenic strains exhibited an enhanced capacity to produce mutagenic metabolites of BP following treatment with MC; the B10.M, B10.WB and B10.D2 segregated with the B6 and B10 in this regard, while the B10.S and B10.RIII changed least following MC administration.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis*; D001564:Benzo(a)pyrene / Q000378:metabolism / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004790:Enzyme Induction; D005260:Female; D007700:Kinetics; D008748:Methylcholanthrene / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009152:Mutagenicity Tests; D009154:Mutation; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects
D001564:Benzo(a)pyrene; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases