title: Muscle proteins related to microtubule associated protein-2 are substrates for an insulin-stimulatable kinase.
abstract: High molecular weight muscle protein(s), present as a "doublet" (approximately 320 and approximately 290 kDa apparent molecular weight) in partially purified preparations of inhibitor-2 from rabbit skeletal muscle, and homogeneous bovine brain microtubule associated protein-2 are both in vitro substrates for a soluble insulin-stimulatable serine/threonine kinase in 3T3-L1 adipocytes. The high molecular weight muscle substrate "doublet" was specifically immunoprecipitated by affinity-purified anti-microtubule associated protein-2 antibody.
mesh_terms: D000818:Animals; D002417:Cattle; D004789:Enzyme Activation / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology*; D051379:Mice; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008970:Molecular Weight; D009124:Muscle Proteins / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D011817:Rabbits
chemical_list: D007328:Insulin; D008869:Microtubule-Associated Proteins; D009124:Muscle Proteins; D010750:Phosphoproteins; D011494:Protein Kinases