Alpha-thalassemia in blacks: genetic and clinical aspects and interactions with the sickle hemoglobin gene.
Recent advances in molecular genetics have permitted detailed study of the human alpha-globin genes and the causes of alpha-thalassemia. In this review, we examine the causes of alpha-thalassemia in the black population and the consequences of the interactions between alpha-thalassemia and structural hemoglobin variants.
D000755:Anemia, Sickle Cell / Q000235:genetics* / Q000503:physiopathology; D044383:Black People; D004907:Erythrocyte Deformability; D004910:Erythrocyte Membrane / Q000502:physiology; D005914:Globins / Q000235:genetics*; D006451:Hemoglobin, Sickle / Q000235:genetics*; D006801:Humans; D012805:Sickle Cell Trait / Q000235:genetics* / Q000503:physiopathology; D013789:Thalassemia / Q000235:genetics* / Q000503:physiopathology
D006451:Hemoglobin, Sickle; D005914:Globins