[Effect of the lymphocytosis-stimulating factor from Bordetella pertussis on murine lymphoid and hemopoietic cells].
Effect of B. pertussis lymphocytosis-promoting factor (LPF) on the lympho-hematopoietic system of mice was studied. The injection of LPF was shown to sharply enhance endogenous colony formation and to induce a severe depletion of thymus cells, reaching its maximum of day 4. Thymocytes obtained on day 2 or 3 after the injection of LPF produced a suppressive effect on endogenous colony formation. The proliferative activity of hematopoietic stem cells sharply increased under the influence of LPF, though it had no radioprotective action. On the following day after the injection of LPF a steep rise in the number of hematopoietic stem cells was observed in the blood of mice: their content increased 20-fold in comparison with the control level. These data may be important for the evaluation of the side effects of pertussis vaccine on the lympho-hematopoietic system.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D016026:Bone Marrow Transplantation; D002452:Cell Count / Q000187:drug effects / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000528:radiation effects; D007399:Interphase / Q000187:drug effects / Q000528:radiation effects; D008214:Lymphocytes / Q000187:drug effects* / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D037342:Pertussis Toxin; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects / Q000637:transplantation; D013950:Thymus Gland / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors; D010566:Virulence Factors, Bordetella / Q000302:isolation & purification / Q000494:pharmacology*
D010566:Virulence Factors, Bordetella; D037342:Pertussis Toxin
Vliianie limfotsitozstimuliruiushchego faktora Bordetella pertussis na limfoidnye i krovetvornye kletki mysheĭ.