title: Treatment of depression in chronic cocaine and phencyclidine abuse with desipramine.
abstract: An open field trial was conducted comparing desipramine and an active placebo in separate populations of chronic cocaine and phencyclidine (PCP) abusers, who discontinued their abuse. Subjects who received desipramine showed a decrease in depressive symptoms after a 20-40 day period regardless of whether they abused PCP or cocaine.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D003042:Cocaine; D003863:Depression / Q000188:drug therapy* / Q000209:etiology; D003891:Desipramine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010622:Phencyclidine; D010919:Placebos; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D010919:Placebos; D003042:Cocaine; D010622:Phencyclidine; D003891:Desipramine