Vestibular morphological analysis of the effects of cisplatin vs. platinum analogs, CBDCA (JM-8) and CHIP (JM-9).
Synthetic second generation chemotherapeutic platinum analogs are presently being tested to identify an analog with greater antitumor activity, but less ototoxicity and nephrotoxicity than cisplatin. The objective of this study was to analyze potential vestibular effects of cisplatin and of the two platinum analogs, CBDCA (cis-diammine 1,1-cyclobutane dicarboxylato [2]-0,0(1) platinum or JM-8) and CHIP (cis-dichlorotrans-dihydroxy-bis(isopropylamine) platinum [IV] or JM-9) using scanning and transmission electron microscopy of vestibular neuroepithelium from the albino guinea pig. Vestibular neuroepithelial damage was not demonstrated in either cisplatin- or the analog-treated animals when administered at equitoxic doses.
D000818:Animals; D016190:Carboplatin; D002945:Cisplatin / Q000633:toxicity*; D006168:Guinea Pigs; D008855:Microscopy, Electron, Scanning; D009944:Organoplatinum Compounds / Q000633:toxicity*; D012444:Saccule and Utricle / Q000187:drug effects / Q000648:ultrastructure; D014722:Vestibule, Labyrinth / Q000187:drug effects* / Q000648:ultrastructure
D009944:Organoplatinum Compounds; C023359:iproplatin; D016190:Carboplatin; D002945:Cisplatin