Advanced stage III ovarian carcinoma. Prospective randomized trials comparing radiotherapy and chemotherapy.
A prospective randomized trial was carried out in 128 patients with advanced stage III ovarian tumors of serous and anaplastic type, to compare the effects of radiotherapy, single-drug chemotherapy and combination chemotherapy on operability and survival. The effect on operability was about the same for radiotherapy as for combination chemotherapy, whereas single-drug chemotherapy was less effective. The effect on survival was significantly greater with the combination chemotherapy than with radiotherapy and single-drug chemotherapy, which were roughly similar. This better survival with combination chemotherapy was observed in both poorly and moderately differentiated tumors.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D011300:Preoperative Care; D011446:Prospective Studies; D011897:Random Allocation