GABA-immunoreactive neurons in the dorsal lateral geniculate nucleus of the rat: characterisation by combined Golgi-impregnation and immunocytochemistry.
Identified neurons in the dorsal lateral geniculate nucleus (dLGN) of the rat were studied using a Golgi/EM procedure in combination with post-embedding GABA immunocytochemistry. The results of this investigation identify clearly the GABA-immunoreactive nature of the two morphologically distinct neuronal populations found within the rat dLGN--thalamocortical relay cells are GABA-immunonegative whilst the putative 'interneurons' are GABA-immunopositive. This immunocytochemical evidence strongly suggests that 'interneurons' synthesize and use GABA to mediate their local inhibitory synaptic mechanisms within the dLGN of the rat.
D000818:Animals; D005829:Geniculate Bodies / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure; D007124:Immunoenzyme Techniques; D007395:Interneurons / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid