Effects of cyclosporin A on the activity of mouse natural killer cells and hybrid resistance.
It was found that a single dose of cyclosporin A (CSA) administered intraperitoneally resulted in rapid, but transitory reduction of (C57B1/6 X DBA/2)F1 spleen cell natural killer (NK) activity (on day 1 after CSA), then a return to the normal level (on day 3 after CSA) and finally gradual, but sharp decrease of this activity (the lowest activity on day 9). It was also found that CSA injected 3 days before semi-allogenic bone marrow transplantation (BMT) has no effect on hybrid resistance (HR), but administered 9 days before BMT caused abrogation of HR. So, there was a correlation between changes of NK activity after CSA and effects of CSA on HR, suggesting that NK cells are responsible for HR. In contrast, there was no effect of CSA on the engraftment of syngeneic bone marrow cells.
D000818:Animals; D016026:Bone Marrow Transplantation; D003524:Cyclosporins / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D005260:Female; D006824:Hybridization, Genetic / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007694:Killer Cells, Natural / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL / Q000145:classification; D014185:Transplantation, Isogeneic
D003524:Cyclosporins