From king to culprit: tobacco.
D004739:England; D049669:History, 16th Century; D049670:History, 17th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D006801:Humans; D008800:Mexico; D012907:Smoking / Q000266:history; D000074606:Smoking Prevention; D014481:United States