Chromosomal changes in a documented case of malignant histiocytosis: significance of polyploidy.
A case of malignant histiocytosis was studied by cytology, cytochemistry, electron microscopy, and cytogenetics. It was shown that the malignant cells expressed a fully differentiated histiocytic pattern with high macrophagic activity. This correlated with the presence of polyploid metaphases. The significance of polyploid cells in the definition of malignant histiocytosis is discussed.
D000368:Aged; D006801:Humans; D007621:Karyotyping; D008206:Lymphatic Diseases / Q000235:genetics*; D008297:Male; D008854:Microscopy, Electron; D011123:Polyploidy