A double-blind gluten-free/gluten-load controlled trial in a secure ward population.
A double-blind control trial of gluten-free versus a gluten-containing diet was carried out in a ward of maximum security hospital: 24 patients were studied for 14 weeks. Most suffered from psychotic disorders, particularly schizophrenia. Various dimensions of behaviour were rated on the Psychotic In-Patient profile (PIP) at different stages. There were beneficial changes in the whole group of patients between pre-trial and gluten-free period in five dimensions of the PIP, maintained during the gluten challenge period; these changes could be attributed to the attention the patients received. Two patients improved during the gluten-free period and relapsed when the gluten diet was reintroduced.
D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005512:Food Hypersensitivity / Q000150:complications; D005983:Glutens / Q000008:administration & dosage* / Q000009:adverse effects; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000178:diet therapy* / Q000209:etiology; D012563:Schizophrenia, Paranoid / Q000178:diet therapy
D005983:Glutens