title: Seroepidemiology of Klebsiella bacteremic isolates and implications for vaccine development.
abstract: The frequencies of capsular serotypes among 703 Klebsiella strains isolated from the blood of hospitalized patients were determined. More than 90% of the isolates were typeable, with 69 of the 77 known serotypes being identified. Serotypes 2, 21, and 55, representing 8.9, 7.8, and 4.8% of all the isolates, respectively, were observed at a frequency significantly higher (P less than 0.05) than that for other capsular serotypes. Approximately 43% of the serotypes appeared at a frequency of less than 0.5%. Differences were found when the seroepidemiology of North American and European isolates was compared. The current findings indicate that a capsular polysaccharide-based vaccine against Klebsiella organisms is feasible and should be multivalent, eliciting antibodies directed against the 25 serotypes which make up approximately 70% of all the bacteremic isolates.
mesh_terms: D001428:Bacterial Vaccines / Q000276:immunology*; D005060:Europe; D006801:Humans; D007709:Klebsiella / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification; D007710:Klebsiella Infections / Q000382:microbiology* / Q000517:prevention & control; D007711:Klebsiella pneumoniae / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification; D009656:North America; D011135:Polysaccharides, Bacterial / Q000276:immunology; D018805:Sepsis / Q000382:microbiology*; D012703:Serotyping
chemical_list: D001428:Bacterial Vaccines; D011135:Polysaccharides, Bacterial