Sodium retention in response to saline infusion in uncomplicated diabetes mellitus.
The response to a 21 infusion of physiological saline infusion was studied in 7 male uncomplicated insulin-dependent diabetics and in 7 non-diabetic male controls. The urinary sodium excretion in the diabetics in each of the 4 hr following the infusion was approximately half that of the controls. The total induced sodium excretion in controls was 34 +/- 4 mmols (mean +/- SEM) but only 14 +/- 4 mmols in the diabetics (p less than 0.005). The hourly creatinine clearance rate was higher in diabetics than in controls indicating a mechanism of reduced sodium excretion via enhanced tubular reabsorption rather than impaired filtration. This propensity to sodium retention in diabetics may play a role in the tendency to cardiovascular and renal complications.
D001786:Blood Glucose / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D012016:Reference Values; D012964:Sodium / Q000097:blood / Q000652:urine*; D012965:Sodium Chloride / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D012965:Sodium Chloride; D012964:Sodium; D003404:Creatinine