[Drug-induced pemphigus].
A review of the literature on previous cases of drug-induced pemphigus as well as two case reports of pyritinole-induced pemphigus show a few characteristics: D-penicillamine was responsible in 42 cases, pyritinole in 4 cases, the two case reports included. Superficial pemphigus was seen in about 75% of the cases, most times associated with preexistent autoimmunological disorders. Immunological findings were identical with normal, non-drug-induced pemphigus, while the prognosis was better under mostly necessary immunosuppressive therapy at relatively low doses.
D000368:Aged; D003176:Complement C3 / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D010392:Pemphigus / Q000139:chemically induced* / Q000473:pathology; D010396:Penicillamine / Q000009:adverse effects*; D011725:Pyridines / Q000009:adverse effects*; D011746:Pyrithioxin / Q000009:adverse effects*; D012867:Skin / Q000473:pathology
D003176:Complement C3; D007074:Immunoglobulin G; D011725:Pyridines; D011746:Pyrithioxin; D010396:Penicillamine
Arzneimittelbedingter Pemphigus.