title: UV-type damage associated with ionizing radiation: a review.
abstract: The induction of UV-type damage by ionizing radiation in repair deficient strains of E. coli is reviewed. Both photoreactivable and non-photoreactivable types of damage can be observed. The induction of UV-type damage is largely independent of the presence of free-radical reactive agents (e.g. oxygen and thiols), but is dependent upon the energy of the photon--or electron--beam used, the radiation geometry and the optical absorbance of the extracellular medium. On the basis of calculations and experimental evidence, it is clear that one mechanism whereby such damage arises is through the generation of Cerenkov emission. However, small yields of UV-type damage can be produced using X-rays whose energy is below the threshold for production of Cerenkov emission. In this instance, the damage induction mechanism is thought to involve a direct excitation process.
mesh_terms: D000042:Absorption; D004260:DNA Repair / Q000528:radiation effects; D004269:DNA, Bacterial / Q000528:radiation effects; D004583:Electrons; D004926:Escherichia coli / Q000378:metabolism / Q000528:radiation effects*; D008027:Light; D009154:Mutation; D010100:Oxygen / Q000378:metabolism; D011827:Radiation; D011831:Radiation Genetics; D011839:Radiation, Ionizing; D014466:Ultraviolet Rays
chemical_list: D004269:DNA, Bacterial; D010100:Oxygen