title: A brief history of the influence of trace elements on brain function.
abstract: From this brief review of history it is evident that lead, mercury, iodine, cobalt, iron, copper, manganese, and zinc have important influences on brain development and function. Identity of thresholds at which effects occur is needed for determination of safe and/or essential levels of these elements in diets. Such knowledge will help define human needs for essential elements, and the hazards of toxic elements.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000196:embryology / Q000502:physiology*; D002648:Child; D003035:Cobalt / Q000172:deficiency; D003300:Copper / Q000172:deficiency; D005260:Female; D049669:History, 16th Century; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D006801:Humans; D007223:Infant; D007455:Iodine / Q000172:deficiency; D000090463:Iron Deficiencies; D007855:Lead Poisoning / Q000150:complications; D008345:Manganese / Q000172:deficiency; D020149:Manganese Poisoning; D008431:Maternal-Fetal Exchange; D008630:Mercury Poisoning / Q000150:complications; D009422:Nervous System Diseases / Q000209:etiology / Q000266:history; D009784:Occupational Diseases / Q000209:etiology / Q000266:history; D011247:Pregnancy; D014131:Trace Elements / Q000266:history / Q000494:pharmacology*; D015032:Zinc / Q000172:deficiency
chemical_list: D014131:Trace Elements; D003035:Cobalt; D008345:Manganese; D003300:Copper; D007455:Iodine; D015032:Zinc