Lymphocyte immunoglobulin secretion during short-term treatment with cephalosporins in vivo and in vitro: effects on plaque-forming cell response of human peripheral blood lymphocytes.
The influence of 4 cephalosporins on the plaque-forming cell (PFC) generation in mitogen-activated cultures of human lymphocytes (PBL) was assessed. In vitro, suprapharmacological concentrations of the drug resulted in a decreased PFC response, while pharmacological concentrations did not influence the generation of PFC. Cells exposed to drugs for 24 h in vivo and propagated in autologous serum in vitro showed a decreased PFC response.
D000328:Adult; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D002511:Cephalosporins / Q000494:pharmacology*; D005260:Female; D006462:Hemolytic Plaque Technique; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male
D002511:Cephalosporins