title: Electron microscopic study of Bitot's spots.
abstract: The histological and structural features of Bitot's spots are described. Light microscopy revealed squamous metaplasia with keratinization. Electron microscopy showed severe loss and attenuation in height of microvilli as well as widening of the intercellular spaces. The amorphous material overlying the conjunctiva was composed of cellular debris containing edemetous endoplasmic reticular membranes and lysozomes.
mesh_terms: D000293:Adolescent; D001706:Biopsy; D003229:Conjunctival Diseases / Q000473:pathology*; D004847:Epithelial Cells; D005404:Fixatives; D006801:Humans; D008297:Male; D008679:Metaplasia / Q000473:pathology; D008871:Microvilli / Q000473:pathology; D013666:Tears / Q000378:metabolism; D014792:Visual Acuity
chemical_list: D005404:Fixatives