Effects of a new pyrazolo [3, 4-d]pyrimidine on growth and morphology of Candida albicans.
A new pyrazolo [3, 4-d]pyrimidine derivative was synthesized and its antifungal activity evaluated in vitro against mycelial and yeast cells of Candida albicans. The most striking ultrastructural changes following treatment with 10-30 micrograms/ml (mycelia) and 25-75 micrograms/ml (yeasts) consisted in the deterioration of the organelle membranes and in aberrant thickenings of the cell wall. The complete disorganization of the cytoplasmic structures seemed to be the final event.
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D002473:Cell Wall / Q000187:drug effects; D006801:Humans; D007425:Intracellular Membranes / Q000187:drug effects; D008854:Microscopy, Electron; D011743:Pyrimidines / Q000494:pharmacology*
D000935:Antifungal Agents; D011743:Pyrimidines; C048934:1-phenyl-3-methyl-6-trifluoromethyl-pyrazolo(3,4-d)pyrimidine-4(5H)thione