title: Methotrexate resistance and gene amplification. Mechanisms and implications.
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002873:Chromosome Fragility; D004261:DNA Replication; D004351:Drug Resistance; D005784:Gene Amplification; D006801:Humans; D008727:Methotrexate / Q000494:pharmacology*; D009369:Neoplasms / Q000188:drug therapy; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics*
chemical_list: D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate