title: Nephrotic-range proteinuria and hyperglycemia associated with clonidine therapy.
abstract: Glycosuria, hyperglycemia, and nephrotic-range proteinuria developed in a 68-year-old patient after clonidine was added to a stable antihypertensive regimen, which included metoprolol, of three years' duration. He later became glucose-intolerant with fasting hyperglycemia. Clonidine has been reported to transiently impair glucose tolerance. Persistent diabetes in a previously normoglycemic patient following clonidine has not been reported, and it supports the possibility that clonidine and metoprolol may have additive effects in suppressing endogenous insulin secretion.
mesh_terms: D000368:Aged; D003000:Clonidine / Q000009:adverse effects* / Q000494:pharmacology; D004357:Drug Synergism; D006029:Glycosuria / Q000139:chemically induced*; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D007328:Insulin / Q000378:metabolism; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D011507:Proteinuria / Q000139:chemically induced*
chemical_list: D007328:Insulin; D008790:Metoprolol; D003000:Clonidine