title: Genetic vulnerability to schizophrenia.
abstract: The genetic contribution to schizophrenia is the most clearly established etiologic factor. This article briefly reviews the evidence for a genetic influence as well as recent challenges to that evidence. It discusses the possible modes of transmission and outlines current efforts to identify more precisely the genetic and environmental factors contributing to schizophrenia and the nature of the gene-environment interaction.
mesh_terms: D000300:Adoption; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D004247:DNA / Q000032:analysis; D004200:Diseases in Twins; D004777:Environment; D005260:Female; D005819:Genetic Markers; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D008995:Monoamine Oxidase / Q000097:blood; D011859:Radiography; D012306:Risk; D012559:Schizophrenia / Q000209:etiology / Q000235:genetics*; D012560:Schizophrenia, Catatonic / Q000235:genetics; D012562:Schizophrenia, Disorganized / Q000235:genetics; D012563:Schizophrenia, Paranoid / Q000235:genetics; D012621:Seasons; D014430:Twins, Monozygotic; D014777:Virus Diseases / Q000150:complications
chemical_list: D005819:Genetic Markers; D006680:HLA Antigens; D004247:DNA; D008995:Monoamine Oxidase