Preparation of microcapsules from complex coacervation of Gantrez-gelatin. II. In vitro dissolution of nitrofurantoin microcapsules.
Nitrofurantoin crystals were encapsulated in a Gantrez-gelatin complex coacervation system. The encapsulation process was reproducible and inexpensive and the microcapsules were free flowing and directly compressible into tablets. In vitro release of nitrofurantoin from Gantrez-gelatin microcapsules was studied as a function of the core:coat ratio, the molecular weight of Gantrez and the particle size of the microcapsules. The release of the drug was significantly reduced using G149-gelatin microcapsules of core:coat ratio of 1:2. Release data were examined kinetically and were found to follow a diffusion-controlled model. In vitro release of the drug from the microcapsules filled in capsules and compressed into tablets confirmed the efficiency of the encapsulation process for preparing prolonged release formulations.
D002214:Capsules; D005780:Gelatin; D007700:Kinetics; D009582:Nitrofurantoin / Q000008:administration & dosage*; D010316:Particle Size; D012995:Solubility; D013607:Tablets
D002214:Capsules; D013607:Tablets; D005780:Gelatin; D009582:Nitrofurantoin