title: Ineffectiveness of clorsulon against Nanophyetus salmincola in coyotes.
abstract: Efficacy of clorsulon against the trematode Nanophyetus salmincola was evaluated in coyotes. Ten 16-week-old coyote pups were fed fish that contained metacercariae of N. salmincola. Twenty-one days later, 5 of the coyotes were given a suspension of clorsulon (approx 16 mg/kg of body weight, orally). Within 30 days after treatment, the numbers of fluke eggs in fecal specimens from the 5 treated coyotes had not decreased, and numbers of fluke eggs and flukes recovered from treated coyotes at necropsy did not differ from numbers of fluke eggs and flukes recovered from 5 untreated coyotes. Therefore, clorsulon at a dosage of 16 mg/kg was not effective against N. salmincola.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D002335:Carnivora / Q000469:parasitology*; D003967:Diarrhea / Q000188:drug therapy / Q000662:veterinary; D005399:Fishes; D010270:Parasite Egg Count / Q000662:veterinary; D013424:Sulfanilamides / Q000627:therapeutic use*; D014201:Trematode Infections / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000871:Anthelmintics; D013424:Sulfanilamides; C015675:clorsulon