Involvement of chromosomal region 9q34 in a case of variant Ph1 translocation t(22;22).
In a patient with chronic myelocytic leukemia chromosome analysis showed a translocation (22;22) (q13;q11). Chromosomes 9 were apparently not involved. Using somatic cell hybrids and a v-abl probe, we demonstrated the translocation of c-abl sequences from chromosome 9 to chromosome 22q-. This confirms the hypothesis that the translocation of c-abl oncogene is essential for the development of Ph1 positive CML.
D002871:Chromosome Banding; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D010677:Philadelphia Chromosome; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D014178:Translocation, Genetic
D011518:Proto-Oncogene Proteins