Co-encapsulation of cyclosporin and insulin by liposomes.
Evidence for an association of both hydrophilic insulin and hydrophobic cyclosporin with liposomes prepared from egg yolk lecithin, cholesterol, and stearylamine (7:2:2.25 molar ratio) was obtained by Sepharose-4B gel filtration. The method used to prepare unilamellar liposomes containing 29.7 nmol cyclosporin and 2.3 nmol insulin per mu mol of liposomal lecithin is described.
D015060:1,2-Dipalmitoylphosphatidylcholine; D000588:Amines; D002250:Carbon Radioisotopes; D002784:Cholesterol; D003524:Cyclosporins; D007328:Insulin; D008081:Liposomes; D008722:Methods; D010713:Phosphatidylcholines
D000588:Amines; D002250:Carbon Radioisotopes; D003524:Cyclosporins; D007328:Insulin; D008081:Liposomes; D010713:Phosphatidylcholines; D015060:1,2-Dipalmitoylphosphatidylcholine; D002784:Cholesterol; C009317:stearylamine