title: [2 or 1 daily doses of ranitidine in the treatment of reflux esophagitis].
abstract: In a randomized multicentre study 96 patients with mild to moderate types of reflux esophagitis (stages I and II according to Savary-Miller) the effect of 150 mg ranitidine b.i.d. (49 patients) was compared to that of 300 mg ranitidine nocte (47 patients). In both patient groups similar healing rates were observed. 81.6% and 74.5%, respectively, of the patients with esophagitis healed within 6 weeks, and 95.9% and 93.6%, respectively, within 12 weeks. Reflux symptoms disappeared in both treatment groups in 91.8% and 80.9%, respectively, within 6 weeks, and 98.0% and 100%, respectively, within 12 weeks. Drug safety was good. Thus, in mild to moderate types of reflux esophagitis treatment with ranitidine can be reduced to one single dose of 300 mg at night.
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004942:Esophagitis, Peptic / Q000188:drug therapy*; D004945:Esophagoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D011899:Ranitidine / Q000627:therapeutic use*
chemical_list: D011899:Ranitidine
vernacular_title: Zwei oder eine Tagesdosis Ranitidin zur Behandlung der Refluxösophagitis?