On the specificity of human anti-H antibodies.
Anti-H antibodies from 2 homogeneous subgroups of H-deficient individuals (Bombay and Réunion phenotypes) were studied for their specificity with regard to synthetic H oligosaccharides. It appears that Bombay individuals synthesize large amounts of both anti-H type 2 and anti-H type 1 antibodies, whereas Réunion individuals may possess strong anti-H type 1 antibodies, but have only weak anti-H type 2 antibodies in their serum. This can be explained by the presence of small amounts of H-type 2 determinants on the erythrocytes of Réunion individuals contrasting with the complete lack of H determinants on the red cells of Bombay individuals.
D000017:ABO Blood-Group System / Q000235:genetics / Q000276:immunology*; D000918:Antibody Specificity / Q000187:drug effects*; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007163:Immunosorbent Techniques; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000276:immunology; D010641:Phenotype; D011863:Radioimmunoassay / Q000379:methods
D000017:ABO Blood-Group System; D009844:Oligosaccharides