Calcium entry blockers in the treatment of vertebrobasilar insufficiency.
The influence of different calcium entry blockers on the vestibular system was investigated. The paper reports results from animal experiments and also from clinical studies with flunarizine and nimodipine. An animal experimental model of vertebrobasilar insufficiency was developed. The effect of the two drugs on the vestibular nystagmus was studied in Alsatian dogs before and after occluding one vertebral artery. In order to analyze the influence of the drugs on the vestibular nystagmus and on the clinical symptoms in patients with vertebrobasilar insufficiency, different open and double-blind studies were performed.
D000818:Animals; D002986:Clinical Trials as Topic; D004285:Dogs; D005444:Flunarizine / Q000627:therapeutic use*; D006801:Humans; D009553:Nimodipine / Q000627:therapeutic use*; D009759:Nystagmus, Pathologic / Q000188:drug therapy / Q000209:etiology; D010431:Pentoxifylline / Q000627:therapeutic use; D014715:Vertebrobasilar Insufficiency / Q000150:complications / Q000188:drug therapy*; D014717:Vertigo / Q000188:drug therapy / Q000209:etiology
D009553:Nimodipine; D005444:Flunarizine; D010431:Pentoxifylline