[A trial of polychemotherapy of leprosy in the Dakar region. Initial observations on the acceptability of the protocols used].
Since 1982, in Dakar, a controlled essay tests the suitability of several short protocols of multidrug therapy (MDT), some of them being close to those advised by the WHO, others showing a starter stage of a two month daily MDT. In three years, 198 paucibacillary and 123 multibacillary patients have been treated. The short duration of these treatments leads to an important decrease in the load of the Department. The total rate of those who have not attended for the treatment is of 15.2% whereas it was of 52% with DDS monotherapy for a similar treatment duration. Those who gave up don't seem to live in Dakar. To judge by the diligence of the patients, the compliance seems excellent even for the protocols requiring a daily dose of ethionamide: 95% of paucibacillary, 76% of multibacillary patients have maximal attendance. The authors think that any MDT program: must be preceded by a retraining of staffs; must give a priority to the health education of the patients; must involve a home patient search for system.
D000293:Adolescent; D000328:Adult; D002648:Child; D002991:Clofazimine / Q000008:administration & dosage; D003622:Dapsone / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005000:Ethionamide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007917:Leprostatic Agents / Q000627:therapeutic use*; D007918:Leprosy / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D010349:Patient Compliance; D012293:Rifampin / Q000008:administration & dosage; D012675:Senegal
D007917:Leprostatic Agents; D003622:Dapsone; D002991:Clofazimine; D005000:Ethionamide; D012293:Rifampin
Présentation d'un essai de polychimiothérapie de la lèpre dans la région de Dakar. Premières observations sur l'acceptabilité des protocoles utilisés.