Growth of human B cell colonies from peripheral blood of patients with systemic lupus erythematosus.
Human B cell colonies were grown from peripheral blood of 12 patients with systemic lupus erythematosus (SLE) and from 12 healthy control subjects. The SLE group showed a large increase (p less than 0.001) in the number of colony forming cells (CFC) present in peripheral blood as compared with controls. The CFC were of the pre-B cell type. There was also a loss of OKT8+ cell inhibition of B cell colony growth in the SLE group compared with control subjects.
D000328:Adult; D000368:Aged; D001402:B-Lymphocytes; D002478:Cells, Cultured; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D008875:Middle Aged; D013234:Stem Cells; D013601:T-Lymphocytes