COTA (colon-ovarian tumor antigen). An immunohistochemical study.
A goat anti-serum was prepared against mucinous ovarian cyst fluid and absorbed with normal colon and a variety of normal tissues until the only residual immunoreactivity was directed against colon cancer and ovarian tumor mucin. The set of antigenic determinants defined by this anti-serum has been called COTA, standing for colon-ovarian-tumor-antigen. This highly absorbed anti-serum (anti-COTA) was used for immunohistochemical staining of 42 different tissues in parallel with staining with a goat anti-CEA, which was also highly absorbed. The results suggest that COTA is a highly sensitive and specific antigen for colon carcinoma and may have potential for the early detection of malignant changes predictive of cancer of the colon.
D000230:Adenocarcinoma / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D000236:Adenoma / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D000818:Animals; D000918:Antibody Specificity; D000951:Antigens, Neoplasm / Q000032:analysis* / Q000276:immunology; D002272:Carcinoembryonic Antigen / Q000032:analysis* / Q000276:immunology; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D003106:Colon / Q000276:immunology / Q000473:pathology; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; C045043:colon-ovarian tumor antigen, human