title: Effect of streptozotocin-induced diabetes and insulin treatment on the degradation of hexokinase II in the skeletal muscle of the rat.
abstract: The rate of degradation of hexokinase II and the general pool of cytosolic proteins was measured in the skeletal muscle of normal, streptozotocin-diabetic, and insulin-treated streptozotocin-diabetic rats. The rate constant for hexokinase II degradation increases by a factor of 3 in the diabetic as compared with the normal animal. There were analogous alterations observed for the general pool of cytosolic proteins; however, the changes were much more subtle. Insulin treatment restores the increased degradative rate to normal levels in both classes of muscle proteins.
mesh_terms: D000818:Animals; D003600:Cytosol / Q000201:enzymology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000201:enzymology; D006593:Hexokinase / Q000378:metabolism*; D007328:Insulin / Q000627:therapeutic use*; D007700:Kinetics; D008297:Male; D008433:Mathematics; D009132:Muscles / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007328:Insulin; D006593:Hexokinase