Evaluation of drug and chemical toxicity with cell culture systems.
Approaches to the evaluation of drug and other chemical toxicity with mammalian cell culture systems are designed to enhance the predictability of animal models. Identification of toxic agents by in vitro screening tests and studies of mechanisms through which chemicals induce critical lesions at the cellular and subcellular levels help to make those predictions sooner and perhaps single out those target sites and chemicals of most concern.
D000818:Animals; D001681:Biological Assay; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004790:Enzyme Induction / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008954:Models, Biological; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D013347:Subcellular Fractions / Q000187:drug effects