Clozapine in the treatment of tremor.
In an open trial 25 tremor patients were treated with clozapine in small doses (18-75 mg per day). The effect was measured with a new movement analyzer. Nine of 12 essential tremor patients were greatly improved. In six of nine patients with Parkinson tremor and in two combined essential tremor/Parkinson tremor patients tremor almost disappeared. Sedation is a major side effect, but decreases in most patients with time. The risk of agranulocytosis makes blood control necessary.
D000437:Alcoholism / Q000503:physiopathology; D002986:Clinical Trials as Topic; D003024:Clozapine / Q000627:therapeutic use*; D003984:Dibenzazepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology; D014202:Tremor / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
D003984:Dibenzazepines; D003024:Clozapine