Propylthiouracil-induced cholestatic jaundice.
The typical propylthiouracil (PTU)-linked hepatotoxicity, is known to manifest itself by hepatocellular injury with greatly increased serum transaminase values and evidence of hepatic necrosis on liver biopsy. Herewith presented is a 33-year old, thyrotoxic woman who developed cholestatic jaundice two weeks after initiation of PTU therapy. The diagnosis was confirmed by liver biopsy. A causal link between PTU treatment and the cholestatic jaundice was suggested by: the time of onset, typical skin rash and a positive migration inhibition factor (MIF) test to PTU. Awareness of this rare complication of PTU treatment may prevent the performance of unnecessary, expensive and possibly harmful diagnostic procedures.
D000328:Adult; D002779:Cholestasis / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D008263:Macrophage Migration-Inhibitory Factors / Q000032:analysis; D008713:Methimazole / Q000633:toxicity; D011441:Propylthiouracil / Q000009:adverse effects*
D008263:Macrophage Migration-Inhibitory Factors; D008713:Methimazole; D011441:Propylthiouracil