Cytoprotective effect of pirenzepine and palm wine on rats gastric mucosa.
Pirenzepine (Gastrozepin--Boechringer Ingelheim) is selective antimuscarinic blocker (MI-blocker) which has been used in the treatment of peptic ulcer because of its ability to reduce gastric acid secretion. But pirenzepine has also been found to have a cytoprotective effect on gastric mucosa in rats. The aim of the present investigation was to find out if palm wine also has any cytoprotective effect on rat gastric mucosa. Gastric mucosal ulcerations were induced with absolute ethanol. It was found that Pirenzepine induced 57% cytoprotection while palm wine induced 24% cytoprotection in rat gastric mucosa. The protection with the latter substance was not statistically significant, while the effect with pirenzepine was significant.
D000818:Animals; D000431:Ethanol / Q000633:toxicity; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D010890:Pirenzepine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control; D014920:Wine
D010890:Pirenzepine; D000431:Ethanol