title: Clinical pharmacology of nicotine.
abstract: Nicotine is the primary reason why people consume tobacco products and it may contribute to causation of tobacco-related diseases. This chapter reviews the human pharmacology of nicotine, the evidence for a role of nicotine in human disease, and the use of nicotine (gum) as a therapeutic agent in smoking cessation therapy.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000209:etiology; D002319:Cardiovascular System / Q000187:drug effects; D002638:Chewing Gum; D004702:Endocrine Glands / Q000187:drug effects; D006801:Humans; D008171:Lung Diseases / Q000209:etiology; D051379:Mice; D009132:Muscles / Q000187:drug effects; D009374:Neoplasms, Experimental / Q000209:etiology; D009420:Nervous System / Q000187:drug effects; D009538:Nicotine / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000209:etiology; D012306:Risk; D012878:Skin Neoplasms / Q000209:etiology; D012907:Smoking; D014029:Tobacco Use Disorder / Q000517:prevention & control
chemical_list: D002638:Chewing Gum; D009538:Nicotine