title: [Double-blind cross-over comparison of flurbiprofen and indomethacin in osteoarthritis of the knee and hip].
abstract: A randomised double blind cross-over study was conducted in order to compare the therapeutic efficacy and tolerability of flurbiprofen and indomethacin in 16 patients with osteoarthrosis of the knee or hip. 300 mg per diem flurbiprofen and 150 mg per diem indomethacin were given for 14 days. Both treatment were very effective against pain whether spontaneous, under pressure or in movement and against functional limitations, joint mobility and on ESR. Undesirable side effects were noted in 4 flurbiprofen and 5 indomethacin cases.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005480:Flurbiprofen / Q000009:adverse effects / Q000627:therapeutic use*; D006621:Hip Joint; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects / Q000627:therapeutic use*; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D011422:Propionates / Q000627:therapeutic use*; D011897:Random Allocation
chemical_list: D011422:Propionates; D005480:Flurbiprofen; D007213:Indomethacin
vernacular_title: Confronto a doppia cecità cross-over tra flurbiprofen e indometacina nelle osteoartrosi del ginocchio e dell'anca.