title: Augmented plasma renin levels in dehydrated sheep with periventricular lesions.
abstract: Ablation of tissue in the midline anterior wall of the third ventricle (AV3V) of sheep did not consistently alter baseline plasma renin concentration (PRC) in water replete animals, but caused a greatly augmented increase in PRC in response to water deprivation. PRC might increase in these sheep in order to maintain blood pressure, however it is possible that a central inhibitory influence on renal renin release, operative during dehydration, is disrupted by AV3V-lesions.
mesh_terms: D000818:Animals; D001931:Brain Mapping; D003681:Dehydration / Q000097:blood / Q000503:physiopathology*; D004027:Diencephalon / Q000503:physiopathology*; D004231:Diuresis; D005260:Female; D009318:Natriuresis; D009490:Neurosecretory Systems / Q000503:physiopathology*; D012083:Renin / Q000097:blood*; D012756:Sheep; D014882:Water-Electrolyte Balance
chemical_list: D012083:Renin