title: Streptomycin sulphate microspheres: formulation and in vivo distribution.
abstract: Albumin and gelatin microspheres of streptomycin sulphate were formulated and their potential as a drug delivery system for a tuberculostatic agent in vivo was evaluated. Biodistribution was determined by i.v. administration of a 99mTc-labelled microsphere suspension to mice. The radioactivity of the lungs was compared with the radioactivity of the liver, spleen, kidney and heart at 10 min, 60 min, 4 h and 24 h post-injection. The percentage accumulated was higher in the lungs than in the other organs for both albumin and gelatin microspheres.
mesh_terms: D000418:Albumins; D000818:Animals; D002214:Capsules; D004337:Drug Carriers; D004339:Drug Compounding; D005780:Gelatin; D051379:Mice; D013307:Streptomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000418:Albumins; D002214:Capsules; D004337:Drug Carriers; D005780:Gelatin; D013307:Streptomycin