title: [Cefonicid toxicity. I. Effects on the reactivity of the specific immune system].
abstract: The degree of toxicity of the antibiotic Cefonicid on the cellular reactivity of the immune system was evaluated. The effects on some lymphokine (IL-2 and IFN-gamma) production and the degree of proliferation of splenic lymphocytes following mitogen stimulation have been considered. Our results show that Cefonicid does not impair the immune response, except at very high doses (500 micrograms/ml).
mesh_terms: D000818:Animals; D002435:Cefamandole / Q000031:analogs & derivatives* / Q000633:toxicity; D015790:Cefonicid; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice
chemical_list: D002435:Cefamandole; D015790:Cefonicid
vernacular_title: Analisi della tossicita' del cefonicid. I. Effetti sulla reattivita' del sistema immunitario specifico.