Rectal carcinoma in a renal transplant patient. Long-term complication of immunosuppression?
The occurrence of a rectal adenocarcinoma in a 48-year-old man 11 years after he received a cadaveric renal transplant is reported. Since his operation, the patient had been receiving prednisone and azathioprine for immunosuppression. The occurrence of rectal carcinoma in this patient at an early age, after a decade of immunosuppression, suggests an association between the malignancy and his altered immunologic state. Although an increased incidence of skin and reticuloendothelial malignancies in the first five years following renal transplantation has been well documented, few colorectal carcinomas have developed in these patients. Follow-up of transplant patients, however, is only now passing ten years in large numbers of patients. This case suggests that there may be a ten year latency period before transplant patients develop colorectal carcinoma. Such a time course would be similar to that seen in patients with chronic ulcerative colitis, in whom colorectal carcinomas are found. Surveillance colonoscopy for transplant patients beginning ten years after surgery may be necessary.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000000981:diagnostic imaging; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D001466:Barium Sulfate; D003110:Colonic Neoplasms / Q000139:chemically induced; D004733:Enema; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000009:adverse effects / Q000627:therapeutic use; D011859:Radiography; D012004:Rectal Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging; D013997:Time Factors
D007166:Immunosuppressive Agents; D001466:Barium Sulfate; D001379:Azathioprine; D011241:Prednisone