title: On the clinical value of thallium-201 washout analysis in the detection of multiple jeopardized myocardial regions.
abstract: In this study the relative importance of visual assessment and quantitative analysis myocardial stress perfusion scintigraphy in 72 patients with a 40% incidence of triple-vessel coronary disease was tested. The quantitative analysis of the uptake scintigram in combination with a washout rate study of thallium-201 was not superior to the visual analysis with regard to the overall detection of significant coronary disease (obstructions of at least 50%). The sensitivity of the quantitative analysis was 0.85 for the entire population and 0.90 for the triple-vessel disease group (specificity 0.90). Detection of jeopardized myocardial flow regions in patients with triple-vessel disease, however, resulted in a significantly better identification by quantitative analysis. Of the 87 jeopardized flow regions in the 29 patients with triple-vessel disease, 62 regions were detected by the quantitative analysis whereas 48 regions were noted by the visual evaluation. The post-test likelihood of this regional quantitative analysis with respect to the triple-vessel disease was 66%. The incidence of global ischemia as detected by washout abnormalities in cases with no or a maximum of one regional uptake defect was 7%.
mesh_terms: D000787:Angina Pectoris / Q000000981:diagnostic imaging; D000788:Angina Pectoris, Variant / Q000000981:diagnostic imaging; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D003936:Diagnosis, Computer-Assisted; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013793:Thallium
chemical_list: D011868:Radioisotopes; D013793:Thallium