[Importance of morphologic examination of the kidneys of patients with vasorenal hypertension for predicting the results of surgical treatment].
Light-optical, electron microscopic and morphometric studies of biopsy material from kidneys of 24 patients with vasorenal hypertension were performed. It was determined that sclerosis of the arteries and arterioles on the side of the lesion was more marked, than in the contralateral kidney. At a later stage of the disease (more than 3 yr.) there were occasional signs of increased renin-synthesizing activity of the juxtaglomerular apparatus (JGA) with its simultaneous decrease at the stenotic side. JGA activation in the contralateral kidney can be one of the mechanisms supporting hyperrenin arterial hypertension and can prevent the decrease of the blood pressure after surgery. Studying of the biopsy material with the estimation of the sclerosis degree of the arterial tree vessels, as well as JGA activity, is important for prognosing the results of surgical treatment of vasorenal hypertension.
D000328:Adult; D001707:Biopsy, Needle; D006801:Humans; D006978:Hypertension, Renovascular / Q000473:pathology / Q000601:surgery*; D006984:Hypertrophy; D007606:Juxtaglomerular Apparatus / Q000473:pathology; D007668:Kidney / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D012083:Renin / Q000096:biosynthesis; D012598:Sclerosis
D012083:Renin
Znachenie morfologicheskogo issledovaniia pochek bol'nykh vazorenal'noĭ gipertenzieĭ dlia prognoza rezul'tatov khirurgicheskogo lecheniia.