[Immunoglobulins for the prevention of radiation pneumonitis following large-volume irradiation in bronchial carcinoma].
In a randomized study 20 patients with non small cell lung cancer were treated for cure at a linear accelerator. Before, during and after treatment levels of immunoglobulins were measured. At the end of radiation therapy levels of IgA, IgG and IgM decreased. After therapy they increased slowly. 3 months after irradiation the average immunoglobulin levels showed a reduction of 16%. After substitution of immunoglobulins no decrease of the levels was seen. After substitution of immunoglobulins the Karnofsky index was significantly higher. Substituted patients showed a lower rate of radiation pneumonitis.
D002283:Carcinoma, Bronchogenic / Q000150:complications / Q000276:immunology / Q000532:radiotherapy*; D006801:Humans; D007116:Immunization, Passive; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008175:Lung Neoplasms / Q000150:complications / Q000276:immunology / Q000532:radiotherapy*; D008875:Middle Aged; D009367:Neoplasm Staging; D010315:Particle Accelerators; D011014:Pneumonia / Q000517:prevention & control*; D011832:Radiation Injuries / Q000517:prevention & control*; D011879:Radiotherapy Dosage; D011897:Random Allocation; D013997:Time Factors
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Immunglobuline zur Prophylaxe der Strahlenpneumonitis nach grossvolumiger Bestrahlung beim Bronchialkarzinom.