Osteopenia in mice with genetic diabetes.
Bone mass and growth were studied in mice with genetic diabetes (db/db) characterized by obesity, hyperinsulinemia and hyperglycemia, in their lean litter mates (db/+) and in non-diabetic mice of the same strain (+/+). No significant difference was observed between db/+ and +/+ mice. The length, bone mass, bone mineral mass, bone mineral density and content of moisture of the tibia of the db/db mice were significantly decreased compared with the db/+ and +/+ mice. Microradiographs of the distal femur diaphysis of the db/db mice showed a significant reduction of the spongious bone area and of the number and thickness of bone trabeculae with a normal mineralization. The amount of osteoid was significantly increased in the db/db mice. The area of cortical bone of the tibia epiphysis of the db/db mice was significantly decreased compared with the db/+ and +/+ mice. The data suggest the occurrence of osteopenia due to decreased mineralization in mice with genetic diabetes.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D001851:Bone Diseases, Metabolic / Q000150:complications / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology*; D048909:Diabetes Complications; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications* / Q000235:genetics / Q000473:pathology; D005260:Female; D005269:Femur / Q000473:pathology; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity; D009929:Organ Size; D013977:Tibia / Q000473:pathology
D001786:Blood Glucose; D007328:Insulin