L&H variants of Reed-Sternberg cells express sialylated Leu M1 antigen.
Anti-Leu M1 generally does not stain the lymphocytic and histiocytic (L&H) variants of Reed-Sternberg cells in the lymphocyte predominant type of Hodgkin's disease. However, the authors found that after neuraminidase treatment for removal of sialic acid, the L&H cells in more than half of the cases studied could be stained by anti-Leu M1. This result strongly suggests that L&H cells differ from the Reed-Sternberg cells in other types of Hodgkin's disease in their unique capacity to sialylate the 150-kd Leu M1 antigen.
D000941:Antigens / Q000276:immunology*; D006644:Histiocytes / Q000276:immunology* / Q000378:metabolism; D006651:Histocytochemistry; D006689:Hodgkin Disease / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D019158:N-Acetylneuraminic Acid; D009439:Neuraminidase / Q000494:pharmacology; D012794:Sialic Acids / Q000378:metabolism*
D000941:Antigens; D012794:Sialic Acids; D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid