title: Treatment of invasive bladder cancer with a neodymium:YAG laser.
abstract: In a controlled setting a neodymium:YAG laser is capable of producing a transmural coagulation of the bladder wall without perforation. A total of 21 patients with known muscle-invading bladder cancer underwent treatment with transurethral endoscopic application of neodymium:YAG laser energy. One patient suffered a sigmoid colon perforation that possibly was treatment-related but no other complications were observed. Four of 5 patients with clinical stage B1 and 3 of 6 with stage B2 lesions have had normal post-treatment biopsies. Local tumor control has been achieved in only 1 of 4 patients with a clinical stage C tumor and none of 6 with metastatic cancer, although palliative debulking was accomplished.
mesh_terms: D002986:Clinical Trials as Topic; D003558:Cystoscopy; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000601:surgery*