The effect of gluten on HLA-DR in the small intestinal epithelium of patients with coeliac disease.
Frozen sections of control and coeliac jejunal mucosa were examined for HLA-DR staining. In general the staining pattern in the controls and treated coeliac patients was a patchy subapical pattern on villous tips. Untreated coeliac patients gave a different pattern with staining extending to the crypt enterocytes. Gluten challenge in three treated coeliac patients induced an altered staining pattern within 2 h.
D002446:Celiac Disease / Q000276:immunology*; D004848:Epithelium / Q000276:immunology; D005455:Fluorescent Antibody Technique; D005983:Glutens / Q000276:immunology*; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology*; D007583:Jejunum / Q000276:immunology*
D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D005983:Glutens