title: A long-term prospective clinical study of orofacial herpes simplex virus infection in acute leukemia.
abstract: Orofacial mucocutaneous infections resulting from herpes simplex virus (HSV) were detected in 40% of patients with acute leukemia. Of the 34 separate episodes, oral mucosal sites were involved in 22 cases. Evidence to support dissemination of HSV was found in 3 patients on 4 separate occasions. The relationship of neutrophil levels to the onset and resolution of lesions is examined. The value of acyclovir for treatment of these HSV-induced lesions is reported, and the question of administering this agent for routine prophylaxis against HSV in these patients is addressed.
mesh_terms: D000208:Acute Disease; D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D002986:Clinical Trials as Topic; D006560:Herpes Labialis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications*; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D011446:Prospective Studies; D013283:Stomatitis, Herpetic / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000212:Acyclovir