A prospective study of histocompatibility testing for keratoplasty in high-risk patients.
Forty high-risk patients awaiting corneal grafting were randomly selected from a 7-year cumulative list. Twenty were grafted with HLA-A and HLA-B antigen matched material. The other 20 patients were used as controls. Graft survival at two years was 60% (12/20) in the control group and 90% (18/20) in the study group; at five years it was 55% (11/20) in the control group and 85% (17/20) in the study group.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003315:Cornea / Q000098:blood supply; D016039:Corneal Transplantation; D005260:Female; D006085:Graft Survival; D006680:HLA Antigens / Q000032:analysis; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012306:Risk; D013997:Time Factors; D014021:Tissue Preservation
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens