Mechanism of the potentiation of thrombolysis by pentoxifylline (Trental).
Streptokinase induced thrombolysis of radioactive labeled human fibrin clots was potentiated by simultaneous treatment with pentoxifylline (Trental). This appears to be due in part to the prevention of platelet aggregation on the clot. In addition, release of t-PA and PgI2 from the endothelium and increases in red cell deformability may also play a role.
D000818:Animals; D004357:Drug Synergism; D005342:Fibrinolysis; D005343:Fibrinolytic Agents; D006801:Humans; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D008251:Macaca; D010431:Pentoxifylline / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D013300:Streptokinase / Q000494:pharmacology; D013805:Theobromine / Q000031:analogs & derivatives*
D005343:Fibrinolytic Agents; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D013300:Streptokinase; D013805:Theobromine; D010431:Pentoxifylline