[Stomach tolerance of indomethacin derivatives: an endoscopic comparative study in healthy probands].
The effect of 5 days' treatment with indomethacin, acemethacin and proglumethacin on the gastroduodenal mucosa was endoscopically evaluated in healthy volunteers. In a randomised double-blind crossover system 16 subjects received 50 mg t.i.d. indomethacin and 60 mg t.i.d. acemethacin, and a further 16 volunteers received 50 mg t.i.d. indomethacin and 150 mg t.i.d. proglumethacin. After 5 days both proglumethacin and acemethacin caused significantly less gastroduodenal lesions than indomethacin. Possible reasons for the apparently better gastro-duodenal tolerability of both indomethacin derivatives are discussed.
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005753:Gastric Mucosa / Q000187:drug effects*; D005773:Gastroscopy; D006801:Humans; D007210:Indoleacetic Acids / Q000633:toxicity*; D007213:Indomethacin / Q000031:analogs & derivatives* / Q000633:toxicity*; D011897:Random Allocation
D000893:Anti-Inflammatory Agents; D007210:Indoleacetic Acids; C026784:acemetacin; C019541:proglumetacin; D007213:Indomethacin
Magenverträglichkeit von Indometacin und Indometacin-Derivaten: eine endoskopische Vergleichsstudie an gesunden Probanden.