title: [Prospective randomized study of the efficacy of adjuvant hormone therapy in patients with breast cancer].
abstract: Tentative results of a randomized controlled evaluation of the effectiveness of adjuvant hormonal therapy of breast cancer are discussed. The data on 118 cases examined in 1981-1984 were considered on the basis of menstrual cycle characteristics and extension of tumor. The results obtained as a result of an average 16.9 month-long examination pointed to a relatively higher recurrence incidence in untreated patients and suggested that such studies should be continued. Tolerance evaluation established a higher incidence of side-effects in cases treated with diethylstilbestrol (33.3%) than with tamoxifen (3.8%).
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000008:administration & dosage; D004054:Diethylstilbestrol / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008593:Menopause; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent; D011446:Prospective Studies; D011897:Random Allocation; D013629:Tamoxifen / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D013629:Tamoxifen; D007980:Levodopa; D004054:Diethylstilbestrol; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
vernacular_title: Prospektivnoe randomizirovannoe izuchenie éffektivnosti ad"iuvantnoĭ gormonoterapii bol'nykh rakom molochnoĭ zhelezy.