title: [Characteristics of the surface topography of Swiss 3T3 cells with altered proliferative activity].
abstract: A scanning electron microscope study of the Swiss 3T3 cell surface topography was made in association with changes in proliferative activity. On the phase of logarithmic growth the cell shape is similar to that of an actively migrating fibroblast. When the growth promoting factors are depleted, the cells are seen spread and forming numerous cell-to-cell contacts. The stimulation of cell proliferation induced by a 10% serum or by epidermal growth factor is associated with a disturbance of cell interaction because of the centripetal cell contraction.
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure*; D007106:Immune Sera / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D051379:Mice; D008855:Microscopy, Electron, Scanning; D013499:Surface Properties
chemical_list: D007106:Immune Sera; D007328:Insulin; D004815:Epidermal Growth Factor
vernacular_title: Osobennosti topografii poverkhnosti kletok Swiss 3T3 pri izmenenii proliferativnoĭ aktivonosti.