title: Tumour invasion and metastasis: therapeutic implications?
abstract: Invasion and metastasis is the hallmark of tumour malignancy. Some aspects of invasion and metastasis with potential implications for tumour therapy are reviewed: the value of laboratory models; the acquisition of invasiveness and metastatic capability during carcinogenesis; the relationship between growth and invasion; clinical and experimental anti-invasive and antimetastatic agents. The value of joint experimental and clinical research is underscored.
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D002642:Chick Embryo; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use; D006801:Humans; D007797:Laminin / Q000502:physiology; D051379:Mice; D008870:Microtubules / Q000187:drug effects / Q000473:pathology; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000473:pathology / Q000517:prevention & control / Q000628:therapy; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D009374:Neoplasms, Experimental / Q000235:genetics / Q000473:pathology / Q000628:therapy; D009857:Oncogenes; D010960:Plasminogen Activators / Q000502:physiology; D051381:Rats
chemical_list: D000911:Antibodies, Monoclonal; D005419:Flavonoids; D007797:Laminin; D010960:Plasminogen Activators