Efficacies of LICAM(C) and DTPA for the decorporation of inhaled transportable forms of plutonium and americium from the rat.
The efficacies of N1, N5, N10, N14-tetrakis (2,3-dihydroxy-4-carboxybenzoyl)-tetra-azatetradecane [LICAM(C)] and diethylenetriaminepenta-acetic acid (DTPA) (30 mumol/kg body wt.) have been investigated for plutonium (Pu) decorporation after inhalation as the nitrate or tributyl phosphate (TBP) complexes and the data compared with those obtained after its intravenous injection as the citrate. The efficacy of removal of americium (Am) inhaled as the nitrate has also been examined. The results show that: whereas LICAM(C) and DTPA were similarly effective for removing Pu from the blood, LICAM(C) was considerably inferior to DTPA when transportable forms of Pu were inhaled; LICAM(C) is ineffective for the decorporation of Am; the optimum treatment regimen for both Pu and Am involved the prompt and repeated administration of DTPA.
D000336:Aerosols; D000576:Americium / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002614:Chelating Agents / Q000627:therapeutic use*; D002951:Citrates; D006224:Cricetinae; D005260:Female; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D009942:Organometallic Compounds; D010755:Organophosphates / Q000378:metabolism; D004369:Pentetic Acid / Q000627:therapeutic use; D011005:Plutonium / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D013095:Spermidine / Q000031:analogs & derivatives / Q000627:therapeutic use
D000336:Aerosols; D002614:Chelating Agents; D002951:Citrates; D009942:Organometallic Compounds; D010755:Organophosphates; C038503:plutonium tri-n-butylphosphate complex; C041805:americium nitrate; D011005:Plutonium; C034834:LICAM-C; D004369:Pentetic Acid; D013095:Spermidine; D000576:Americium