title: Determinants of drug disposition in man.
abstract: This article reviews some of the important determinants of variation in drug disposition such as age, gender, body weight, diet, environmental influences, drug - protein interactions, compliance, drug - drug interactions, endogenous substances, disease states, circadian variation and genetics.
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D001835:Body Weight; D002940:Circadian Rhythm; D004077:Digoxin / Q000097:blood; D004347:Drug Interactions; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008019:Life Style; D008297:Male; D010349:Patient Compliance; D004364:Pharmaceutical Preparations / Q000097:blood / Q000378:metabolism*; D011485:Protein Binding; D012737:Sex Factors
chemical_list: D004364:Pharmaceutical Preparations; D004077:Digoxin