title: Scopolamine effects in vestibular defensiveness.
abstract: Disturbed vestibular function secondary to brain stem injury may result in postural gravitational insecurity, and aversion reactions or intolerance to movement. The Transderm scopolamine disc was applied in a double-blind, placebo-controlled study of five post-head-injury patients who underwent provocative vestibular stimulation such as turning in a wheelchair, head shaking, and the log roll. Four of the patients showed improvement in exquisite sensitivity to rotational movement. A surprise finding of improved truncal stability in two of the more severely injured patients indicates a potential usefulness of the scopolamine patch for patients with truncal ataxia.
mesh_terms: D001930:Brain Injuries / Q000150:complications / Q000503:physiopathology*; D002986:Clinical Trials as Topic; D004244:Dizziness / Q000209:etiology / Q000517:prevention & control*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D012399:Rotation; D012601:Scopolamine / Q000008:administration & dosage / Q000627:therapeutic use*; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D012601:Scopolamine