Effects of CDP-choline on platelet aggregation and the antiaggregatory activity of arterial wall in the rat.
The effects of the acute (250 mg/kg) and chronic (250 mg/kg for two weeks) treatments with CDP-choline on platelet aggregation and thromboxane formation and on the platelet antiaggregatory activity of thoracic aorta, have been studied in the rat. The acute administration resulted mainly in reduced platelet reactivity to aggregating agents, with no change of platelet thromboxane formation. The antiaggregatory activity of aortic walls was also concomitantly reduced. After chronic treatment, the major effect was a greater antiaggregatory activity of the vessel wall in respect of the control values, whereas platelet function was not affected. CDP-choline treatment, thus exerts favourable effects especially in the acute treatment, by reducing platelet reactivity.
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism; D001158:Arteries / Q000187:drug effects / Q000378:metabolism*; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D011464:Epoprostenol / Q000096:biosynthesis; D066298:In Vitro Techniques; D008297:Male; D010477:Perfusion; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D013929:Thromboxane B2 / Q000096:biosynthesis; D013997:Time Factors
D003566:Cytidine Diphosphate Choline; D013929:Thromboxane B2; D011464:Epoprostenol; D002794:Choline