Dye-mediated photolysis of human neuroblastoma cells: implications for autologous bone marrow transplantation.
Cells from three different human neuroblastoma cell lines and normal human bone marrow cells were exposed to the lipophilic fluorescent dye, merocyanine 540 (MC 540), and white light. In vitro clonogenic tumor cells were inactivated up to 25,000 times more rapidly than multipotent hematopoietic progenitor cells (CFU-GEMM). It is conceivable that this pronounced difference in sensitivity to MC 540-mediated photolysis can be exploited for the selective killing of residual neuroblastoma cells in autologous remission marrow grafts.
D001853:Bone Marrow / Q000473:pathology / Q000528:radiation effects; D016026:Bone Marrow Transplantation; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000473:pathology / Q000528:radiation effects; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology / Q000528:radiation effects; D009447:Neuroblastoma / Q000473:pathology*; D010782:Photolysis; D011744:Pyrimidinones / Q000494:pharmacology*; D014182:Transplantation, Autologous
D011744:Pyrimidinones; C003954:merocyanine dye