Adrenal phenylethanolamine-N-methyltransferase activity in the young rat: influence of thyroid hormones and insulin-induced hypoglycemia.
The postnatal evolution of adrenal phenylethanolamine-N-methyltransferase (PNMT) activity is slightly accelerated by hypothyroidism and slowed by hyperthyroidism. In 14-day-old rats a single stimulation of the adrenals by insulin-induced hypoglycemia does not lead to any change in enzymatic activity. If the stimulation is repeated for 4 days, it leads to a net increase in adrenal PNMT activity in the control rats, while no increase occurs in hypo- or hyperthyroid animals.
D000311:Adrenal Glands / Q000201:enzymology*; D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D005260:Female; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D010625:Phenylethanolamine N-Methyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D013963:Thyroid Hormones / Q000502:physiology*
D007328:Insulin; D013963:Thyroid Hormones; D010625:Phenylethanolamine N-Methyltransferase