The effects of ethanol on embryonic actin: a possible role in teratogenesis.
When the neural crest is cultured in the long or short term presence of ethanol, monoclonal anti-actin reveals the development of a disorganized actin cytoskeleton. In the long term, many cells fail to differentiate morphologically, whereas in the short term already differentiated cells rapidly alter their shape and their cell-to-cell contacts.
D000014:Abnormalities, Drug-Induced; D000199:Actins / Q000378:metabolism*; D000557:Ambystoma / Q000196:embryology; D000818:Animals; D002450:Cell Communication / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000648:ultrastructure; D004247:DNA / Q000096:biosynthesis; D000431:Ethanol / Q000494:pharmacology* / Q000633:toxicity; D005455:Fluorescent Antibody Technique; D009432:Neural Crest / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D014176:Protein Biosynthesis
D000199:Actins; D000431:Ethanol; D004247:DNA