Polyclonal response of human lymphocytes to Chlamydia trachomatis.
The mitogenicity of Chlamydia trachomatis was investigated. Umbilical cord blood cells from healthy newborns were used. These cells were stimulated in cultures with partially purified C. trachomatis elementary bodies. Proliferation of cultured lymphocytes and secreted immunoglobulins and leukocyte migration inhibitory factor were measured in the culture supernatants. Our results showed that C. trachomatis is able to elicit polyclonal antibody, lymphokine, and DNA synthesis.
D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000917:Antibody Formation; D002478:Cells, Cultured; D002692:Chlamydia trachomatis / Q000276:immunology*; D005312:Fetal Blood; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D007231:Infant, Newborn; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*
D000907:Antibodies, Bacterial; D007075:Immunoglobulin M; D007961:Leukocyte Migration-Inhibitory Factors