title: Effect of saccharin on the meiotic division of Saccharomyces cerevisiae.
abstract: The effect of saccharin on the occurrence of meiotic diploid and disomic products in Saccharomyces cerevisiae was investigated. It was found that this substance inhibits the sporulation process in a dose-dependent manner, is ineffectual on recombination frequency, and slightly increases the occurrence of diploid and disomic meiotic products. It is demonstrated that the formation of diploid meiotic products is a consequence of random nuclear fusions at the end of the meiotic process or of endomitosis preceding meiosis.
mesh_terms: D008540:Meiosis / Q000187:drug effects; D012439:Saccharin / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000502:physiology; D013172:Spores, Fungal
chemical_list: D012439:Saccharin