[Toxic properties of the double-stranded RNA of virus-like particles from Saccharomyces cerevisiae killer yeasts].
The toxic properties of dsRNA isolated from S. cerevisiae were studied on noninbred albino mice. The preparation was administered intraperitoneally. The lots of the yeast dsRNA consisted of highly and moderately toxic compounds. The toxicity level was directly associated with the content of the dsRNA in the preparation. Administration of the preparation in doses equal to the maximum tolerance dose and 1/5 of LD50 had no significant effect on the motor activity, temperature and weight of the animals. However, it induced marked morphological impairments in the gastrointestinal tract, liver and kidneys and pronounced shifts in the hematological indices. 1/50 of LD50 had no significant effect on the physiological, hematological and morphological indices of the organs. No capacity for the yeast dsRNA cumulation in the host was observed.
D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D004271:DNA, Fungal / Q000633:toxicity*; D004064:Digestive System / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D012330:RNA, Double-Stranded / Q000633:toxicity*; D012441:Saccharomyces cerevisiae / Q000472:pathogenicity*; D013997:Time Factors
D004271:DNA, Fungal; D012330:RNA, Double-Stranded
Toksicheskie svoĭstva dvuspiral'noĭ RNK virusopodobnykh chastits killernykh drozhzheĭ Saccharomyces cerevisiae.