title: Therapeutic effects of pindolol on behavioral disturbances associated with organic brain disease: a double-blind study.
abstract: A double-blind, placebo-controlled crossover study was conducted to examine the effects of pindolol for the treatment of 11 patients with impulsive, explosive behaviors and other emotional-behavioral abnormalities as a consequence of brain disease or injury. Pindolol treatment was associated with significant therapeutic benefits without sedation and without the use-limiting side effects that occur with propranolol.
mesh_terms: D000328:Adult; D000368:Aged; D000374:Aggression / Q000187:drug effects* / Q000523:psychology; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006760:Hospitalization; D006801:Humans; D007175:Impulsive Behavior / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000188:drug therapy / Q000523:psychology*; D010869:Pindolol / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011433:Propranolol / Q000009:adverse effects; D011889:Rage / Q000187:drug effects; D012894:Sleep Stages; D014754:Violence
chemical_list: D011433:Propranolol; D010869:Pindolol