Effect of irradiation on ethyl nitrosourea induced neural tumours in Wistar rat.
Wistar rats received 2 Gy whole body irradiation followed immediately by 10 mg/kg of ethyl nitrosourea (ENU) on the day of birth. Out of 33 rats which were given ENU alone 14 developed 22 tumours of the nervous system, out of which 15 (68.2%) were gliomas and 7 (31.8%) were Schwannomas. Out of 34 rats which were given both irradiation and ENU 12 were found to harbour 15 neural tumours out of which 14 (93.3%) were gliomas and 1 (7.1%) was a Schwannoma. The pretreatment with irradiation seems to have resulted in selective suppression of Schwannoma induction.
D000818:Animals; D000831:Animals, Newborn; D003043:Cocarcinogenesis; D005038:Ethylnitrosourea; D005910:Glioma / Q000139:chemically induced; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D009423:Nervous System Neoplasms / Q000139:chemically induced*; D009442:Neurilemmoma / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D014916:Whole-Body Irradiation
D005038:Ethylnitrosourea