title: [Therapeutic effect and residues of a Gentavet preparation in chicks, piglets and calves].
abstract: Studied were the therapeutic and prophylactic effects of the preparation Gentavet (containing gentamycin complex II) with pigs, birds and calves affected with colibacteriosis. It was found that in conc. 80,000 IU (0.08 g or 0.8 g) with the drinking water (1 lit.) given 14 days to birds lowered the mortality rate to a higher extent than Avimycin (containing oxitetracycline and neomycin). At the rate of 10,000 IU (0.01 g or 0.1 g) per kg body mass, orally, split in two for 24 h with newborn pigs Gentavet produced a very good prophylactic effect, and when used at a higher rate--16,000 IU (0.016 g or 0.16 g) per kg under the same conditions up to 90 per cent of the pigs with polyenteritis recovered. At 10,000 IU (0.01 g or 0.1 g) per kg body mass, orally, split in two for 24 h with newborn calves with colibacteriosis produced therapeutic and prophylactic effects. Gentamycin complex II residual amounts remained longest in the parenchymal tissue of the kidneys and liver. The withdrawal times in slaughtering birds, pigs, and calves treated with Gentavet should last from 30 to 46 days (31 days for birds, 46 days for pigs and calves of up to 100 kg, and 30 days for heifers of up to 400-500 kg). This period could be shortened 4 to 5 days if both kidneys and liver are to be eliminated after slaughter.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001822:Body Burden; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000662:veterinary; D005839:Gentamicins / Q000378:metabolism / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000188:drug therapy; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy
chemical_list: D005839:Gentamicins
vernacular_title: Lecheben efekt i ostatŭchni veshtestva na preparata Gentavet pri pileta, praseta i teleta.