title: Influence of bile duct occlusion on plasma insulin responses to glucose in rats.
abstract: The plasma insulin and glucose responses to intravenous glucose administration were studied in rats after 1, 3, and 6 weeks of bile duct occlusion. One week after the occlusion the first-phase plasma insulin response to glucose was clearly reduced, whereas the late-phase response was increased. Despite a relative hypoglycemia, a clearly increased glucose-induced elevation of plasma insulin was noted after 3 weeks' bile flow obstruction, at which time the median 15-min plasma insulin response to glucose was 38 microU/ml in duct-occluded rats and 7 microU/ml in control rats (p less than 0.001). At the same time an increased glucose elimination rate of 3.59%/min in duct-occluded rats and 3.08%/min in control rats (median values; p less than 0.05) was observed. Available evidence suggests that the effect on the insulin response may be induced by the trypsin-sensitive branch of the 'enteroinsular axis'.
mesh_terms: D000818:Animals; D001652:Bile Ducts / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose