The effect of ultraviolet radiation on humoral immune responses to T-dependent antigens.
Multiple exposures to broadband ultraviolet (uv) radiation resulted in alterations in the ability of BALB/c mice to produce antibodies to the T-dependent antigens ovalbumin and sheep erythrocytes following intraperitoneal, intradermal, and intravenous inoculation. A number of differences were observed in the influence of uv radiation on the specific cells producing antibody, as opposed to pure serological analyses. While both enhancement and reduction of the humoral response occurred, the experiments have suggested that the alterations in antibody responses following uv irradiation appear to be dependent on the nature of the antigen, the route of antigen administration, and the sometimes transient nature of the responses. The intradermal route of antigen inoculation was under the greatest influence of uv radiation.
D000818:Animals; D000917:Antibody Formation / Q000528:radiation effects*; D006462:Hemolytic Plaque Technique; D000949:Histocompatibility Antigens Class II / Q000528:radiation effects*; D007271:Injections, Intradermal; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000008:administration & dosage* / Q000276:immunology; D014466:Ultraviolet Rays / Q000009:adverse effects*
D000949:Histocompatibility Antigens Class II; D010047:Ovalbumin