Tumor cells stimulate in vivo periosteal bone formation.
It was demonstrated that in mice a variety of tumor cells of both viral (XC, MSVC) and non-viral origin (rat ameloblasts, Ehrlich ascites carcinoma, KB, WAMIB, WISH cell lines) produce, on transplantation in the adjacent bones, periosteal osteogenesis, and in addition can stimulate osteoclastic and tumor-mediated bone resorption. The production by the tumor cells of an osteoblast-activating factor, besides the osteoclast-activating factor described earlier by others, is postulated.
D000818:Animals; D001859:Bone Neoplasms / Q000503:physiopathology*; D051379:Mice; D010012:Osteogenesis