[Detection and significance of serum zona pellucida antibodies in sterile females].
Sera of 100 infertile women and of 100 patients with early pregnancy as control group were investigated for antibodies to zona pellucida by the indirect immunofluorescence. Zonae of oocytes from pigs were used for the procedure. A positive control serum with a high titer was produced by immunization of rabbits with an antigen from pig zonae. The frequency of antibodies to zona pellucida was 29% for infertile patients and 18% in the control group. The titers of these autoantibodies were higher in infertile than in fertile women. There was no increase of these antibodies if the age increased and no relation to the menarche and the ovulation. Antibodies to zona pellucida were demonstrated frequently in patients with disturbances of cycle, free Fallopian tubes, secondary infertility, and ovarian and unknown origin of infertility.
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology; D003251:Constriction, Pathologic / Q000276:immunology; D005184:Fallopian Tube Diseases / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007247:Infertility, Female / Q000276:immunology*; D010063:Ovum / Q000276:immunology*; D011247:Pregnancy; D015044:Zona Pellucida / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens
Nachweis und Bedeutung von Zona-pellucida-Antikörpern im Serum steriler Frauen.