Topographic aspects of prostacyclin-like and fibrinolytic activity and of biogenic amines in the arterial system of the mini-pig.
Although arteriosclerosis is a systemic disease, it nevertheless exhibits noticeable topographical preference and particularities. The reason for this could be lie with certain biochemical features of the arterial wall. We therefore examined prostacyclin-like and fibrinolytic activity in mini-pigs, as well as the concentration of various biogenic amines in the thoracic and abdominal aorta, in coronary arteries and in the carotid and femoral artery. There was a similar behaviour between PG I2-like release and biogenic amines in the different arteries, whereas fibrinolytic activity behaved differently in some cases. In the femoral artery particularly low fibrinolytic activity was confronted by a particularly high level of PG I2-like activity and biogenic amines, while the reverse was the case in the abdominal aorta. In older animals PG I2-like activity considerably decreased.
D000818:Animals; D001158:Arteries / Q000378:metabolism; D001161:Arteriosclerosis / Q000097:blood*; D001679:Biogenic Amines / Q000097:blood*; D004298:Dopamine / Q000097:blood; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D005342:Fibrinolysis; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D009638:Norepinephrine / Q000097:blood; D012701:Serotonin / Q000097:blood; D013552:Swine; D013556:Swine, Miniature
D001679:Biogenic Amines; D012701:Serotonin; D011464:Epoprostenol; D004298:Dopamine; D009638:Norepinephrine