title: [Rational posology and drug dosage].
abstract: Serum level monitoring of drugs allows an optimal drug therapy, because it can take into account individual pharmacokinetic (and metabolic) variations. Some special conditions in drugs and in patients are highly suggestive of drug monitoring. These include mainly physiological but also pharmacological situations and apply to drugs with low therapeutic indices. However, for some drugs, highly bound to proteins or to blood cells, another more specific measurements will take in the future the place of serum level monitoring.
mesh_terms: D000368:Aged; D001682:Biological Availability; D004304:Dosage Forms; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism; D011247:Pregnancy; D011955:Receptors, Drug / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D004304:Dosage Forms; D004364:Pharmaceutical Preparations; D011955:Receptors, Drug
vernacular_title: Posologie rationnelle et dosage des médicaments.