Platelet aggregation is not essential for xenograft rejection.
Five rabbit kidneys were perfused at 80 mm Hg with heparinized human blood, five with platelet poor human blood, and five with human blood added prostacyclin. Time until blood flow decreased to 2 ml/min was significantly delayed by removal of platelets or addition of prostacyclin. Histological examination did not reveal any difference between the groups. It is concluded that platelets play an enhancing role, but they are not essential for xenograft rejection.
D000818:Animals; D011464:Epoprostenol / Q000097:blood; D005455:Fluorescent Antibody Technique; D006084:Graft Rejection; D006801:Humans; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D016030:Kidney Transplantation; D010477:Perfusion / Q000379:methods*; D010974:Platelet Aggregation; D010976:Platelet Count; D011817:Rabbits; D014183:Transplantation, Heterologous
D011464:Epoprostenol