Obesity, overeating, and rapid gastric emptying in rats with ventromedial hypothalamic lesions.
Measurements confirm the quantitative theoretical prediction that the autonomic nonendocrine abnormality of rapid daytime gastric emptying is the major primary cause of the obesity resulting from ventromedial hypothalamic lesions in rats. Therapy for obesity could include slowing of stomach emptying.
D000818:Animals; D001068:Feeding and Eating Disorders / Q000503:physiopathology*; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D006963:Hyperphagia / Q000209:etiology / Q000503:physiopathology*; D007328:Insulin / Q000494:pharmacology; D009765:Obesity / Q000209:etiology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014697:Ventromedial Hypothalamic Nucleus / Q000502:physiology*
D007328:Insulin