Genetic and anti-tubulin effects induced by pyridine derivatives.
A series of pyridine derivatives, 2-methyl-, 2-chloro-, 2-acetyl-, 3-acetyl-, 4-acetyl, 2-phenyl-, 2,4-dimethyl-, 2,6-dimethyl- and 2-methyl-5-ethyl-pyridine, were shown to induce mitotic aneuploidy in strain D61.M of Saccharomyces cerevisiae. Induction of mitotic recombination was also observed with 3- and 4-acetylpyridine and 2-phenylpyridine in strain D61.M. 4-Acetylpyridine and 2-phenylpyridine were found to induce mitotic gene conversion and 2-phenyl-pyridine also induced reverse mutation in strain D7 of Saccharomyces cerevisiae. These two agents also inhibited the GTP-mediated assembly of porcine brain tubulin in vitro.
D000782:Aneuploidy; D005785:Gene Conversion / Q000187:drug effects; D008870:Microtubules / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects*; D009154:Mutation / Q000187:drug effects*; D011485:Protein Binding / Q000187:drug effects; D011725:Pyridines / Q000633:toxicity*; D011995:Recombination, Genetic / Q000187:drug effects; D012441:Saccharomyces cerevisiae; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000502:physiology
D011725:Pyridines; D014404:Tubulin