Early diagnosis and intrauterine therapy of meconium plug syndrome in the fetus: risks and benefits.
Two cases are reported of patients in the third trimester of pregnancy in whom routine ultrasound examination revealed progressive dilatation of the fetal intestines. Intestinal obstruction was suspected and amniocentesis as well as amniography with Urografin were done. In both cases a regression in dilatation of bowel was noted on ultrasonography. The Urografin swallowed by the fetus was deemed to have relieved the obstruction of the fetal intestine. The babies were delivered in good condition and passed large amounts of watery meconium per rectum. In spite of the risks inherent in the use of Urografin amniography, as well as of amniocentesis, there appear to be a great number of advantages to the treatment of meconium obstruction of the fetus in utero.
D000328:Adult; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000000981:diagnostic imaging; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000627:therapeutic use*; D005069:Evaluation Studies as Topic; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn; D007415:Intestinal Obstruction / Q000175:diagnosis* / Q000188:drug therapy; D008470:Meconium; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011859:Radiography; D012306:Risk; D013577:Syndrome; D014463:Ultrasonography
D003973:Diatrizoate; D003974:Diatrizoate Meglumine