title: Pancreatic proteases and oxygen-derived free radicals in acute ischemic enteropathy.
abstract: The specific susceptibility of the intestinal mucosa to low blood flow states is related to the "physiologic" makeup of the intestinal milieu. Pancreatic proteases appear to play a crucial role in the ischemic autodigestion of the intestinal mucosa. Moreover, trypsin can activate the conversion of xanthine dehydrogenase into superoxide radicals producing xanthine oxidase. Oxygen-derived free radicals account for at least part of the damage to the postischemic intestinal mucosa.
mesh_terms: D000818:Animals; D005609:Free Radicals; D006801:Humans; D007413:Intestinal Mucosa / Q000098:blood supply*; D007511:Ischemia; D010100:Oxygen / Q000633:toxicity; D010179:Pancreas / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000494:pharmacology*; D014357:Trypsin / Q000494:pharmacology*
chemical_list: D005609:Free Radicals; D010447:Peptide Hydrolases; D014357:Trypsin; D010100:Oxygen