title: Myelopeptides--bone marrow mediators with immunostimulating and endorphin-like activity.
abstract: Bone marrow cells produce soluble mediators with structural and functional heterogeneity. They were found to stimulate antibody production at the peak of the immune response, owing to compounds of a peptide nature (Mr 2000-1300). Active material was isolated by means of gel chromatography and electrophoresis. This material positively reacts with ninhydrin, and has maximum absorption close to 278 nm. Its antibody-stimulating activity decreased or stopped completely after treatment with proteolytic enzymes. Apart from the immunostimulating activity, bone marrow mediators have opiate-like activity. They have an analgetic effect, and interact with the opiate receptors of brain nerve cells. After a physicochemical and functional analysis, we conclude that bone marrow produces regulatory peptides that were previously unknown. We called them myelopeptides.
mesh_terms: D000700:Analgesics / Q000302:isolation & purification; D000818:Animals; D000917:Antibody Formation; D001853:Bone Marrow / Q000502:physiology*; D002415:Cats; D002850:Chromatography, Gel; D004723:Endorphins / Q000302:isolation & purification; D005260:Female; D008297:Male; D051379:Mice; D010447:Peptide Hydrolases; D010455:Peptides / Q000302:isolation & purification / Q000502:physiology*; D013552:Swine
chemical_list: D000700:Analgesics; D004723:Endorphins; D010455:Peptides; D010447:Peptide Hydrolases