Group-specific component (Gc): subtypes in the Finnish population. Description of a new allele and an apparent mother-child incompatibility.
The group-specific component (Gc) subtypes were determined in 575 adult Finns by immunoblotting after isoelectric focusing in agarose gel. The gene frequencies were Gc1S = 0.661, Gc1F = 0.139 and Gc2 = 0.200. This material included one rare allele, a more acidically focusing Gc 2 (named Gc 2A18). The phenotypes of 200 mother-child pairs studied were in accordance with the three-allelic mode of inheritance. An apparent mother-child incompatibility observed during routine paternity testing is reported.
D000483:Alleles; D005387:Finland; D005787:Gene Frequency; D006801:Humans; D007163:Immunosorbent Techniques; D010375:Pedigree; D014809:Vitamin D-Binding Protein / Q000235:genetics*
D014809:Vitamin D-Binding Protein