Evaluation of Thimet 10-G for mutagenicity by 4 different genetic systems.
The insecticide Thimet 10-G was tested for mutagenic activity by 4 different genetic systems. It was unable to induce gene mutation in Salmonella, transfection inhibition in Mycobacterium, micronuclei formation in mice, and sister-chromatid exchange (SCE) in human lymphocytes were evaluated. It caused in mice an increase in the ratio of normochromatic to polychromatic erythrocytes and in human lymphocytes a decrease in mitotic index and delay in cell cycle. The results indicate that the insecticide is not mutagenic in the 4 test systems used at present.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects; D004912:Erythrocytes / Q000648:ultrastructure; D006801:Humans; D066298:In Vitro Techniques; D007306:Insecticides / Q000633:toxicity*; D008214:Lymphocytes / Q000648:ultrastructure; D051379:Mice; D008940:Mitotic Index / Q000187:drug effects; D009152:Mutagenicity Tests; D009153:Mutagens; D009161:Mycobacterium / Q000235:genetics; D010702:Phorate / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects; D012854:Sister Chromatid Exchange / Q000187:drug effects; D014162:Transfection / Q000187:drug effects
D007306:Insecticides; D009153:Mutagens; D010702:Phorate