Combined clofazimine- and dapsone-resistant leprosy. A case report.
A preliminary report is presented on the finding in a patient with lepromatous leprosy relapsing after maintaining clinical inactivity and bacterial negativity with dapsone monotherapy for a period of 23 years. Interestingly, Mycobacterium leprae from the fresh skin lesions revealed resistance to both clofazimine and dapsone by standard mouse foot pad testing.
D000328:Adult; D000818:Animals; D002991:Clofazimine / Q000494:pharmacology*; D003622:Dapsone / Q000494:pharmacology* / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D006801:Humans; D007918:Leprosy / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D051379:Mice; D009166:Mycobacterium leprae / Q000187:drug effects*
D003622:Dapsone; D002991:Clofazimine