The effect of lincomycin on exoprotein production by Vibrio cholerae.
Lincomycin has a differential effect on exoprotein production by Vibrio cholerae. The production of some proteins, such as cholera toxin and deoxyribonuclease, is stimulated by low concentrations of the drug while production of other proteins, such as protease and alkaline phosphatase, is unaffected. Possible mechanisms of the lincomycin effect are discussed.
D000469:Alkaline Phosphatase / Q000096:biosynthesis; D001426:Bacterial Proteins / Q000096:biosynthesis*; D003851:Deoxyribonucleases / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D004768:Enterotoxins / Q000096:biosynthesis; D008034:Lincomycin / Q000494:pharmacology*; D009154:Mutation; D010447:Peptide Hydrolases / Q000096:biosynthesis; D014734:Vibrio cholerae / Q000187:drug effects* / Q000378:metabolism
D001426:Bacterial Proteins; D004768:Enterotoxins; D008034:Lincomycin; D003851:Deoxyribonucleases; D000469:Alkaline Phosphatase; D010447:Peptide Hydrolases