Synergistic activity of rabbit granulocyte peptides against Candida albicans.
Rabbit granulocytes contain six antimicrobial peptides that are structurally homologous to the human neutrophil "defensins." NP-5, a rabbit defensin, lacks significant activity against Candida albicans. Nevertheless, its addition to submicromolar concentrations of rabbit NP-1, NP-2, or NP-3a potentiates their candidacidal effect. Thus, granulocyte defensins can act synergistically against potential pathogens.
D000818:Animals; D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides; D002176:Candida albicans / Q000276:immunology*; D004357:Drug Synergism; D006098:Granulocytes / Q000276:immunology*; D011506:Proteins / Q000633:toxicity*; D011817:Rabbits
D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides; D011506:Proteins