title: Caustic ingestions. Pathophysiology, diagnosis, and treatment.
abstract: More than 5,000 caustic ingestions are estimated to occur each year. Liquid lye is associated with the greatest morbidity. Endoscopy is the only method for evaluating the extent of the injury; clinical signs and symptoms (e.g., vomiting, dysphagia, abdominal pain, oral burns, leukocytosis) are not reliable. In less severe burns (involving only mucosal irritation or ulceration), current therapy with antibiotics and steroids results in a very favorable prognosis. Circumferential or very deep burns have a much poorer outcome, with a greatly increased risk of stricture formation and/or perforation. The risk of developing esophageal carcinoma may be 1,000 times greater for individuals who have had a lye burn than in the general population. It cannot be overemphasized that prevention is still the key to decreasing this morbidity.
mesh_terms: D000667:Ampicillin / Q000627:therapeutic use; D000818:Animals; D002057:Burns, Chemical / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D002424:Caustics / Q000009:adverse effects*; D004938:Esophageal Neoplasms / Q000209:etiology; D004945:Esophagoscopy; D004947:Esophagus / Q000293:injuries*; D006801:Humans; D007223:Infant; D008892:Milk; D011241:Prednisone / Q000627:therapeutic use; D011379:Prognosis; D014481:United States; D014867:Water / Q000627:therapeutic use
chemical_list: D002424:Caustics; D014867:Water; D000667:Ampicillin; D011241:Prednisone