In situ degradation of rapidly transported proteins in nerve terminals of retinal ganglion cells.
The in situ degradation of rapidly transported proteins in nerve terminals of retinal ganglion cells was studied in pieces of the superior colliculus of the rabbit. Proteolytic degradation was found to be dependent upon extracellular calcium and intact calcium channels. Degradation was inhibited by leupeptin and SH-group blocking agents.
D000818:Animals; D001369:Axons / Q000378:metabolism; D001692:Biological Transport; D002118:Calcium / Q000502:physiology; D005260:Female; D008297:Male; D009411:Nerve Endings / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D011817:Rabbits; D012160:Retina / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000378:metabolism*; D013477:Superior Colliculi / Q000378:metabolism
D009419:Nerve Tissue Proteins; D010447:Peptide Hydrolases; D002118:Calcium