title: [Pathomorphologic aspects of the conservative therapy of arthroses].
abstract: The paper reviews the different ways in which osteoarthrosis can occur. Structural alterations that take place in the subchondral bone or in the collagenous network of the superficial or mid-zone cartilage can be regarded as the initial events leading to injuries of the chondrocytes. Loss of cartilage either due to increased enzymatic degradation and/or reduced synthesis of proteoglycans may follow. The hypothetical influence of pharmacotherapy on several pathogenetic steps is discussed. However, from the viewpoint of a pathologist, it is concluded that there is no pharmacotherapeutic regimen that can significantly influence the natural course of the disease.
mesh_terms: D001847:Bone Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D002357:Cartilage Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007592:Joint Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D007596:Joints / Q000378:metabolism / Q000473:pathology; D010020:Osteonecrosis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D011509:Proteoglycans / Q000378:metabolism
chemical_list: D011509:Proteoglycans
vernacular_title: Pathomorphologische Aspekte zur konservativen Therapie der Arthrose.