Statistical evaluation of prognostic factors in ALL and treatment results.
Prognostic factor evaluation is a frequent and desirable investigative activity in clinical trials. Nevertheless, a number of errors in the evaluation of such factors occur quite commonly. Many of these problems are due to inappropriate statistical interpretation of the analyses that are conducted. A detailed discussion of several problem areas is given. In the area of childhood ALL trials, issues related to the appropriate choice of disease end-points for analysis of prognostic factors are discussed.
D000704:Analysis of Variance; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D007945:Leukemia, Lymphoid / Q000401:mortality* / Q000628:therapy; D007958:Leukocyte Count; D011379:Prognosis; D012044:Regression Analysis; D013223:Statistics as Topic