Effects of flunarizine on Metrazol-induced seizures in developing rats.
Antimetrazol action of flunarizine (5, 10, 20 and 40 mg/kg i.p.) was tested during ontogenesis on male Wistar rats aged 7, 12, 18, 25 and 90 days. The latencies and incidences of jerks, minimal Metrazol seizures and major Metrazol seizures remained unchanged by flunarizine in all age groups. A specific action (an abolition of the tonic phase of major seizures) was seen throughout the development and was reflected in lower scores of seizures.
D000375:Aging / Q000502:physiology*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005444:Flunarizine / Q000627:therapeutic use*; D008297:Male; D010433:Pentylenetetrazole / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology
D000927:Anticonvulsants; D005444:Flunarizine; D010433:Pentylenetetrazole