Influence of serum lipoproteins and carbohydrate metabolism on erythrocyte membrane composition in children: Bogalusa Heart Study.
The influence of serum lipoprotein profile and measures of carbohydrate metabolism on erythrocyte membrane composition were examined in four groups of children (n = 356, ages 6 to 18 years) from a total biracial population whose earlier very low density (VLDL-C) or low density lipoprotein cholesterol (LDL-C) levels (or both) were in the extreme quintiles or quartiles. Erythrocyte membranes of white children contained significantly increased levels of protein (+2.0%) and phospholipid (+2.7%) and decreased levels of neutral sugars (-4.6%) when compared to black children. Membrane neutral sugars were markedly higher (+4.7%) in girls than in boys. Membrane protein was lowest in children characterized by high LDL-C and low VLDL-C. The phospholipid/protein ratio was consistently higher (+1.9%) in the low VLDL-C strata. The relationships between membrane constituents and plasma/serum variables were explored after controlling for race, sex, and age effects and after combining the four selection groups. Less membrane cholesterol was present in the lowest (v highest) quintile of serum LDL-C/high density lipoprotein cholesterol (HDL-C) ratio (P less than 0.01). Membrane phospholipid levels were lower in the highest (v lowest) quintiles of the apoB/apoA-I ratio (P less than 0.01). With respect to measures of carbohydrate tolerance, membrane hexosamine showed low values in the highest (v lowest) quintile of hemoglobin A1c, while the trend was opposite for plasma insulin response (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008563:Membrane Lipids / Q000097:blood; D008565:Membrane Proteins / Q000097:blood
D001786:Blood Glucose; D002241:Carbohydrates; D007328:Insulin; D008074:Lipoproteins; D008563:Membrane Lipids; D008565:Membrane Proteins