title: Treatment of radiofibrosis with liposomal superoxide dismutase. Preliminary results of 50 cases.
abstract: Well and long established radio-fibroses have been treated successfully with a liposomal encapsulated bovine copper superoxide dismutase. After a short treatment (three weeks intramuscular injection of 5 mg twice a week) regression of the fibrosis is stable. The average size is reduced by one third and significant softening occurs in 82% of the cases. Efficiency is independent of the time between radiotherapy (origin of the fibrosis) and treatment with liposomal SOD. Complete regression even after this limited treatment is seen in cases of chronic prefibrotic inflammatory syndromes and prophylactic action in cases where the probability of fibrosis formation is certain appears to be successful. The roles of superoxide and superoxide dismutase are discussed.
mesh_terms: D003300:Copper / Q000008:administration & dosage / Q000627:therapeutic use; D004337:Drug Carriers; D005355:Fibrosis / Q000188:drug therapy; D006801:Humans; D007273:Injections, Intramuscular; D008081:Liposomes; D009369:Neoplasms / Q000532:radiotherapy; D011832:Radiation Injuries / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D003300:Copper; D013482:Superoxide Dismutase