[Antimicrobial chemoprevention in colorectal interventions: a single parenteral dose at the start of surgery is adequate].
The effectivity in reducing septic complications after colorectal operations of oral 1 g Neomycin plus 0.25 g Metronidazol t.i.d. on the last preoperative day vs. intravenous single dose 5 g Mezlocillin plus 0.5 g Metronidazole was tested by sequential medical plan. There was no statistically significant difference between both chemoprophylaxis groups (p = 0.10). It is concluded that the intravenous chemoprophylaxis should be preferred because of the lowest dosage and therefore the fewest side-effects.
D000284:Administration, Oral; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000517:prevention & control; D001431:Bacteriological Techniques; D003108:Colonic Diseases / Q000601:surgery*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008795:Metronidazole / Q000097:blood / Q000627:therapeutic use; D008802:Mezlocillin / Q000627:therapeutic use; D008875:Middle Aged; D009355:Neomycin / Q000627:therapeutic use; D011292:Premedication; D011897:Random Allocation; D012002:Rectal Diseases / Q000601:surgery*; D013530:Surgical Wound Infection / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D008795:Metronidazole; D009355:Neomycin; D008802:Mezlocillin
Antimikrobielle Chemoprophylaxe bei colorectalen Eingriffen: Parenterale Einmalgabe bei Operationsbeginn ausreichend.