Effect of ketotifen on the bronchodilating action of aminophylline.
The use of methyl xanthine derivatives for the treatment of bronchospasm is limited by unwanted side-effects which are frequently dose related. Potentiation of the bronchodilating effects of these derivatives would therefore have obvious clinical advantages. This paper reports the results of a trial designed to elucidate whether potentiation occurs between aminophylline and ketotifen.
D000293:Adolescent; D000328:Adult; D000628:Aminophylline / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D001249:Asthma / Q000517:prevention & control; D001980:Bronchi / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007665:Ketotifen / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010919:Placebos; D013806:Theophylline / Q000097:blood
D010919:Placebos; D000628:Aminophylline; D013806:Theophylline; D007665:Ketotifen