Factors affecting drug biotransformation.
Biotransformation of drugs to polar metabolites is a key step in the termination of action and the elimination of drugs used in therapeutics. A large number of factors, including infection, alter the basal rates of drug metabolism and cause a number of untoward effects and drug interactions. Although a number of techniques have been attempted, there appears to be no easy way to determine the capacity of an individual to metabolize a specific drug and to tailor drug dosage to that individual.
D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D007239:Infections / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008657:Metabolic Clearance Rate; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System