Receptor-independent low-density lipoprotein catabolism.
Cultured cells, animal models, and man all possess mechanisms for LDL degradation that do not require the agency of the high-affinity receptor. In healthy individuals their functional significance can be determined using LDL which has been modified by specific chemical reactions designed to inhibit it receptor binding. Although the precise nature of the pathways has not been defined, there is evidence to implicate the monocyte-macrophage system in the process.
D000818:Animals; D002478:Cells, Cultured; D003512:Cyclohexanones / Q000494:pharmacology; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism; D007202:Indicators and Reagents; D007457:Iodine Radioisotopes; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000302:isolation & purification / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D008745:Methylation; D011865:Radioisotope Dilution Technique; D011973:Receptors, LDL / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D014461:Ultracentrifugation / Q000379:methods
D003512:Cyclohexanones; D007202:Indicators and Reagents; D007457:Iodine Radioisotopes; D008077:Lipoproteins, LDL; D011973:Receptors, LDL; C018031:1,2-cyclohexanedione