title: Medium chain triglycerides (MCT) in aging and arteriosclerosis.
abstract: Some of the nutritional work with triglycerides consisting mainly of C8 and C10 fatty acids (MCT) lends itself to speculations about their influence on arteriosclerosis. Arteriosclerosis is thought to be part of the normal aging process which is due to age associated molecular biological changes. The lipid theory of arteriosclerosis is rejected. Pertinent studies with MCT include these observations. Feeding of MCT to rats resulted in animals of low body weight, small fat deposits and excellent survival rate. This deserves emphasis because of the beneficial influence of low body weight on aging and arteriosclerosis. MCT feeding was associated with low linoleate and low tocopherol requirements in rats. This may lead to reduced formation of those linoleate derived prostaglandins which favor thrombosis formation. Lower linoleate requirements may also lead to the presence of fewer uncontrolled free radicals in the cells. MCT feeding is associated with low levels of serum and liver cholesterol involving speculations that tissue conditions are such that an adaptive increase of cholesterol is unnecessary. The Demographic Yearbook of the United Nations (1978) reported that Sri Lanka has the lowest death rate from ischemic heart disease. Sri Lanka is the only of the countries giving reliable data where coconut oil (containing over 50% medium chain fatty acids) is the main dietary fat.
mesh_terms: D000375:Aging; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology* / Q000517:prevention & control; D001835:Body Weight; D004041:Dietary Fats / Q000494:pharmacology; D002149:Energy Intake; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism; D013927:Thrombosis / Q000209:etiology; D014280:Triglycerides / Q000494:pharmacology*
chemical_list: D004041:Dietary Fats; D008041:Linoleic Acids; D014280:Triglycerides; D019787:Linoleic Acid