Molecular and cellular mechanisms of porphyrin photosensitization.
Mechanisms of porphyrin-sensitized photochemistry involving biomolecular substrates have been studied in a diverse array of in vitro and in vivo experimental protocols. Porphyrin-sensitized, singlet oxygen-mediated photooxidative damage has been implicated in peroxidation of cell membrane lipids; cross-linking of cell membrane and intracellular proteins; inhibition of cell membrane associated, cytosolic, mitochondrial and microsomal enzymes; disruption of intracellular organelles with release of inflammatory mediators and hydrolases; damage to DNA with retarded protein synthesis and delay in cell cycle; and activation of complement-generated inflammatory events leading to cell injury or death.
D002462:Cell Membrane / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism; D003167:Complement Activation / Q000528:radiation effects; D004247:DNA / Q000378:metabolism; D006414:Hematoporphyrin Photoradiation; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008563:Membrane Lipids / Q000378:metabolism; D010100:Oxygen / Q000502:physiology; D010777:Photochemistry; D010787:Photosensitivity Disorders / Q000473:pathology; D011166:Porphyrins / Q000378:metabolism / Q000528:radiation effects*
D008563:Membrane Lipids; D011166:Porphyrins; D004247:DNA; D002784:Cholesterol; D010100:Oxygen