Selective renal medullary damage and hypertension in the rat: the role of vasopressin.
The induction of selective renal medullary damage by 2-bromoethylamine hydrobromide (BEA) results in polyuria and raised blood pressure. In view of the likely elevation of plasma vasopressin we have investigated the role of vasopressin (AVP) in the elevated blood pressure in this model. Plasma vasopressin levels in BEA pretreated rats were raised significantly (2 +/- 0.6 pg/ml vs 0.8 +/- 0.1 in normal rat, P less than 0.05) but not to pressor levels. In addition, pressor responsiveness was investigated in renal medullary damaged rats. There was a reduced response to vasopressin and noradrenaline but no alteration with angiotensin II. A specific V1, receptor AVP antagonist [d(CH2)5Tyr(Me)AVP] produced no fall in blood pressure but returned the noradrenaline dose-response curve to normal. This suggests an interaction between vasopressin and the sympathetic nervous system in this model. Thus there is no evidence that vasopressin contributes to the rise in blood pressure produced by chemical renal medullectomy and other mechanisms have to be sought.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005021:Ethylamines; D005260:Female; D006977:Hypertension, Renal / Q000097:blood* / Q000139:chemically induced / Q000503:physiopathology; D007679:Kidney Medulla; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D012083:Renin / Q000097:blood; D014667:Vasopressins / Q000097:blood*
D005021:Ethylamines; C004504:2-bromoethylamine; D014667:Vasopressins; D000804:Angiotensin II; D001127:Arginine Vasopressin; D012083:Renin; D009638:Norepinephrine