Kinetic description of proteolysis. Part 1. Peptic hydrolysis of proteins isolated from chicken heart: optimization in terms of time and substrate concentration.
Simple equation for the total rate of proteolysis is proposed. The equation, based on the renal mechanism of proteolysis includes the substrate concentration and some functions of the degree of hydrolysis. These functions are experimentally determined in the case of peptic hydrolysis of chicken heart proteins. The integration of differential equation made it possible to describe the kinetics of the proteolysis in terms of substrate concentration, degree of proteolysis and reaction time. The kinetics of proteolysis does not obey the Michaelis-Menten law. The proposed way for mathematical modelling permits the optimization by productivity.
D000818:Animals; D002645:Chickens; D006868:Hydrolysis; D007700:Kinetics; D009124:Muscle Proteins / Q000032:analysis*; D009206:Myocardium / Q000032:analysis*; D010447:Peptide Hydrolases; D014020:Tissue Extracts / Q000032:analysis
D009124:Muscle Proteins; D014020:Tissue Extracts; D010447:Peptide Hydrolases