Effect of acrylonitrile on the transcription of specific genes in Saccharomyces cerevisiae.
We have studied the effect of acrylonitrile on the transcription of specific genes of Saccharomyces cerevisiae. The results presented demonstrate that ACN disturbs the coordinated response of ribosomal protein genes and causes a dramatic induction of the LEU2 gene, which might be due to metabolites of ACN.
D050539:3-Isopropylmalate Dehydrogenase; D000181:Acrylonitrile / Q000494:pharmacology*; D000429:Alcohol Oxidoreductases / Q000235:genetics; D005796:Genes / Q000187:drug effects*; D005800:Genes, Fungal / Q000187:drug effects*; D009570:Nitriles / Q000494:pharmacology*; D012269:Ribosomal Proteins / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects*
D009570:Nitriles; D012269:Ribosomal Proteins; D000429:Alcohol Oxidoreductases; D050539:3-Isopropylmalate Dehydrogenase; D000181:Acrylonitrile