Screening Azadirachta indica and Pisum sativum for possible antimalarial activities.
Solvent-free extracts obtained from the leaves of Azadirachta indica and Pisum sativum were screened for antimalarial action using Plasmodium berghei in mice. Four days of oral dosing with 500 mg/kg and 125 mg/kg of the methanol extract of A. indica showed a parasite suppression which was statistically significant although all test animals died after 5 days, just 1 day longer than the untreated control group. A 50 mg/kg oral dose of the aqueous extract of P. sativum was found to have significant prophylactic activity by producing a parasite suppression of 31.9%.
D000818:Animals; D000962:Antimalarials; D002738:Chloroquine / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D007887:Fabaceae; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D010962:Plasmodium berghei / Q000187:drug effects; D013045:Species Specificity
D000962:Antimalarials; D010936:Plant Extracts; D002738:Chloroquine