[Biochemical and ultrastructural changes in animal brain after intracisternal administration of the cerebrospinal fluid from patients with schizophrenia].
After intracisternal administration of liquor from patients with schizophrenia into rabbits and rats content of catecholamines, gangliosides and cerebrosides was decreased, while acid proteinase was activated in brain tissue. At the same time, ultrastructural impairments occurred in nervous cells. These data suggest that cytotoxic antibrain antibodies are present in liquor of schizophrenic patients.
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D002395:Catecholamines / Q000378:metabolism; D002555:Cerebrospinal Fluid / Q000276:immunology*; D002946:Cisterna Magna; D006017:Glycolipids / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000134:cerebrospinal fluid*; D007267:Injections; D010447:Peptide Hydrolases / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000276:immunology
D002395:Catecholamines; D006017:Glycolipids; D007074:Immunoglobulin G; D010447:Peptide Hydrolases
Biokhimicheskie i ul'trastrukturnye izmeneniia v mozge zhivotnykh pri intratsisternal'nom vvedenii likvora bol'nykh shizofrenieĭ.