title: Mutation of Escherichia coli capable of expressing gene(s) for beta-lactamase production of Citrobacter freundii.
abstract: A mutation in a chromosomal gene of Escherichia coli, designated reb, acted in trans to increase the expression of the cloned beta-lactamase gene of Citrobacter freundii. The reb gene was located around 99 min. Deletion mutants in the cloned gene(s) which had lost the regulatory region for induction were also constructed.
mesh_terms: D002954:Citrobacter / Q000201:enzymology* / Q000235:genetics; D003001:Cloning, Molecular; D004926:Escherichia coli / Q000235:genetics; D005786:Gene Expression Regulation; D005798:Genes, Bacterial; D009154:Mutation; D011815:R Factors; D013696:Temperature; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001618:beta-Lactamases