title: The combined effect of DBE and X-rays on the induction of somatic mutations in Tradescantia.
abstract: The induction of somatic mutations in the stamen hair cells of Tradescantia KU 9 has been used to investigate the effects of combined exposure to 1,2-dibromoethane (DBE) and X-rays. At low radiation doses a synergistic interaction has been found between the two agents for both DBE exposure followed by acute X-rays and chronic simultaneous exposures. The synergism is discussed in terms of an interaction of single strand lesions in the DNA. It is concluded that although this type of interaction should not be too important for radiological protection, it could be of significance in evaluating the effects of chemicals at low exposure rates.
mesh_terms: D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D015946:Ethylene Dibromide / Q000494:pharmacology*; D006842:Hydrocarbons, Brominated / Q000494:pharmacology*; D009154:Mutation; D010944:Plants / Q000187:drug effects / Q000528:radiation effects; D011831:Radiation Genetics; D013997:Time Factors
chemical_list: D006842:Hydrocarbons, Brominated; D015946:Ethylene Dibromide