MHC-linked genetic factors (HLA-B35) influencing recurrent circumoral herpetic lesions.
The frequencies of HLA-A, B, C, DR, and DQ lymphocyte alloantigens were determined in 31 Sicilian patients with recurrent herpetic lesions (RHL) and compared to frequencies observed in normal individuals. A significant negative association was found for HLA-B35 (pc = 0.049). The relationships between HLA and immune responses to viral infections are discussed in light of the results revealed by the present investigation suggesting that HLA-linked genetic factors may play a role in the pathogenesis of RHL. The results seem to indicate that genes in the major histocompatibility complex (MHC) are influential against developing RHL.
D000328:Adult; D005260:Female; D005787:Gene Frequency; D005805:Genes, MHC Class I; D008040:Genetic Linkage; D015235:HLA-B Antigens / Q000235:genetics*; D015797:HLA-B35 Antigen; D006560:Herpes Labialis / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D012008:Recurrence; D012802:Sicily
D015235:HLA-B Antigens; D015797:HLA-B35 Antigen