Protection of mice against lethal endotoxemia by a lipid A precursor.
Lipid X, the major biosynthetic precursor of lipid A, has recently been described. Although lipid X is a mitogen and coagulates the Limulus amebocyte lysate, we found that it is not lethal for mice, even when given in large doses (2 X 10(6) micrograms/kg). Furthermore, lipid X was found to give partial protection against a 100% lethal dose of endotoxin, even if the lipid X was given as late as 6 h after endotoxin challenge.
D000818:Animals; D004334:Drug Administration Schedule; D004731:Endotoxins / Q000037:antagonists & inhibitors*; D004926:Escherichia coli; D006017:Glycolipids / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D008050:Lipid A / Q000031:analogs & derivatives*; D051379:Mice; D012772:Shock, Septic / Q000188:drug therapy / Q000517:prevention & control*; D013329:Structure-Activity Relationship
D004731:Endotoxins; D006017:Glycolipids; D008050:Lipid A; C044283:lipid X