Hypertension and other complications in human obesity.
Human obesity is characterized by differences in the distribution of excess fat. Only when obesity is mainly located in the abdominal regions are obesity-associated diseases prevalent, including hypertension. It is possible that this is due to an excess production of free fatty acids from these lipolytically active depots. This, in turn, might cause hyperinsulinemia via reduced hepatic insulin uptake, followed by peripheral hyperinsulinemia, insulin resistance and, perhaps, diabetes mellitus and hypertension.
D000886:Anthropometry; D005060:Europe; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008297:Male; D009765:Obesity / Q000145:classification / Q000150:complications* / Q000378:metabolism; D011446:Prospective Studies; D012306:Risk
D005230:Fatty Acids, Nonesterified