[Development and practical use of new experimental models of the various forms of herpetic infection].
New experimental models of neurological herpes in cotton rats and genital herpes in male guinea pigs have been developed which are more adequate to the corresponding human diseases, and models of ophthalmic herpes in rabbits and guinea pigs have been improved. These models may be used for screening and evaluation of the effectiveness of drugs for herpes. A high activity against herpes of bromovinyldeoxyuridine and acyclovir has been verified, a marked therapeutic effect of Soviet monophosphates ara-A, ara-C, and original silur preparation in some forms of herpes infection has been demonstrated.
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D003411:Arvicolinae; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006561:Herpes Simplex / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007635:Keratitis, Dendritic / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D008297:Male; D008590:Meningoencephalitis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D051379:Mice; D011817:Rabbits; D014776:Virus Cultivation
D000998:Antiviral Agents
Razrabotka i prakticheskoe ispol'zovanie novykh éksperimental'nykh modeleĭ raznykh form gerpeticheskoĭ infektsii.