Effect of a non-hygroscopic surfactant coating upon fluorescein absorption from the respiratory tract.
The influence of a hydrophobic coating upon the absorption of fluorescein from the canine respiratory tract has been evaluated. Lauric acid was adsorbed onto the surface of micronized disodium fluorescein powder suspended in non-aqueous solutions of the fatty acid. A 0.24 g lauric acid coating for each gram of dye was sufficient to prevent hygroscopic growth in a 40 sec period at 37 C at 97% relative humidity. When this powder was aerosolized and administered by inhalation to Beagle dogs, fluorescein absorption proceeded at similar rates to that of the uncoated dye.
D000042:Absorption; D000818:Animals; D004285:Dogs; D005452:Fluoresceins; D006207:Half-Life; D007700:Kinetics; D007850:Lauric Acids / Q000494:pharmacology*; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000187:drug effects; D013501:Surface-Active Agents
D005452:Fluoresceins; D007850:Lauric Acids; D013501:Surface-Active Agents; C030358:lauric acid