Persistence of t(4;11) in cytologically normal bone marrow treated ex vivo with Asta-Z.
The chromosomal anomaly t(4;11) is closely related to a specific type of acute leukemia: occurrence in young children, hyperleukocytosis with a particular immunologic phenotype, and poor response to therapy. Allogeneic bone marrow (BM) transplantation has been done in a few cases. We report a case in which a complete remission was obtained after intensive therapy. Because no donor was available, an autologous BM transplantation was performed after purge ex vivo of the BM collection by Asta-Z. Relapse occurred at day 45.
D001853:Bone Marrow / Q000648:ultrastructure*; D016026:Bone Marrow Transplantation; D002905:Chromosomes, Human, 4-5; D002906:Chromosomes, Human, 6-12 and X; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000235:genetics* / Q000628:therapy; D014178:Translocation, Genetic
C037933:Asta Z 7557; D003520:Cyclophosphamide