T-lymphocyte involvement in abscess formation in nonimmune mice.
Athymic mice formed significantly smaller abscesses than euthymic mice in response to the intraperitoneal inoculation of an abscess-inducing mixture of Escherichia coli, Bacteroides fragilis, and autoclaved colonic contents, an abscess-potentiating agent. Adoptive transfer of nonimmune, Thy-1-positive spleen cells to athymic mice restored their ability to make abscesses of sizes similar to those in controls, indicating that T lymphocytes contribute to abscess formation in normal mice.
D000038:Abscess / Q000276:immunology*; D000818:Animals; D001439:Bacteroides / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D007111:Immunity, Cellular; D007116:Immunization, Passive; D051379:Mice; D010529:Peritoneal Cavity / Q000382:microbiology; D013601:T-Lymphocytes / Q000276:immunology*