Influence of SLO4 on the leucocyte migration inhibiting factor and on the DTH response.
This phase I study demonstrates the immunostimulating properties of SLO4 administered by the oral route in the healthy volunteer. Responses to the test of DTH (delayed type hypersensitivity) were enhanced by SLO4 and the production of MIF (migration inhibiting factor) involved in this response was stimulated. These properties could be correlated with the previously demonstrated induction of interferon by SLO4.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000284:Administration, Oral; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007700:Kinetics; D007711:Klebsiella pneumoniae; D007961:Leukocyte Migration-Inhibitory Factors / Q000097:blood*; D008222:Lymphokines / Q000097:blood*; D012882:Skin Tests
D000276:Adjuvants, Immunologic; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines