title: The nature of the antigen-antibody bond and the factors affecting its association and dissociation.
abstract: Considering that generally both Coulombic and van der Waals' bonds occur in AG-AB interactions, for AG-AB dissociation both interactions have to be made repulsive simultaneously. The theory and practice of repulsive van der Waals' interactions are outlined. Also treated are the hysteresis of AG-AB dissociation contrasted with the inhibition of association; dissociation of hydrogen bonds; dissociation by haptens; dissociation by alteration of tertiary and secondary configurations; and physical methods of dissociation.
mesh_terms: D000818:Animals; D000915:Antibody Affinity; D000936:Antigen-Antibody Complex; D000937:Antigen-Antibody Reactions; D001666:Binding Sites, Antibody; D001667:Binding, Competitive; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006241:Haptens; D006801:Humans; D006860:Hydrogen Bonding; D006863:Hydrogen-Ion Concentration; D007477:Ions; D007700:Kinetics; D009994:Osmolar Concentration; D011485:Protein Binding; D011487:Protein Conformation; D011489:Protein Denaturation; D012995:Solubility; D012997:Solvents; D013010:Sonication; D013329:Structure-Activity Relationship; D013696:Temperature; D013816:Thermodynamics; D014867:Water
chemical_list: D000936:Antigen-Antibody Complex; D006241:Haptens; D007477:Ions; D012997:Solvents; D014867:Water