Cyclosporin A in pediatric kidney transplantation and its effect on posttransplantation growth.
Results of cyclosporin A (CyA) treatment following kidney transplantation in 28 children were compared with those of conventional immunosuppression with azathioprine (Aza) in 34 children. CyA was given in combination with low-dose prednisolone. Under CyA the 2-year survival rate of patients and grafts was 96%, under Aza the 2-year survival rate of patients was 94% and of grafts 68% (p less than 0.01). Graft function was slightly lower in the CyA than in the Aza group. Growth after kidney transplantation was evaluated in those patients with a first graft and a function of longer than 1 year. Annual growth velocity for bone age was normal or even accelerated in all children treated with CyA and significantly better than in the children treated with Aza. It is concluded that CyA treatment combined with low-dose prednisolone yields excellent results and allows normal growth rates after kidney transplantation.
D000293:Adolescent; D001379:Azathioprine / Q000627:therapeutic use; D002648:Child; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D003524:Cyclosporins / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use
D003524:Cyclosporins; D004338:Drug Combinations; D011239:Prednisolone; D001379:Azathioprine