title: Biventricular function during volume loading in porcine E. coli septic shock, with emphasis on right ventricular function.
abstract: In 14 anesthesized pigs, the effect of E. coli (2 X 10(8)/kg) and volume loading on hemodynamics and right and left ventricular performance were studied. Autologous red cells were labeled in vitro with 99mTC (15-20 mCi). Gated blood pool studies and hemodynamics were performed simultaneously. E. coli infusion resulted in an abrupt increase in pulmonary artery pressure, whereas systemic blood pressure fell gradually. Gated studies showed a transient increase in right ventricular end-diastolic volume (RVEDV) after 1 hour; left ventricular end-diastolic volume (LVEDV) declined gradually during sepsis. During volume loading, RVEDV and LVEDV both increased. As estimated from the altered Frank Starling relation between preload and SW, a depressed performance of both left and right ventricle was found. We conclude that volume expansion in porcine E. coli septic shock results in a uniform increase of left and right preload despite a substantial increase in pulmonary vascular resistance.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D002302:Cardiac Output; D002306:Cardiac Volume; D003971:Diastole; D004926:Escherichia coli; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D011669:Pulmonary Wedge Pressure; D012772:Shock, Septic / Q000503:physiopathology*; D013318:Stroke Volume; D013552:Swine; D014690:Venous Pressure