Altered estrogen action in the senescent rat uterus: a model for steroid resistance during aging.
The estrogen stimulated rat uterus serves as a useful model to examine steroid resistance during aging. This system exhibits receptor loss, impaired stimulation of RNA polymerase II and defects in nuclear translocation (or enhanced association) of receptor-estradiol complexes. All of these defects appear to contribute in part to decreased estrogen responsiveness of the senescent rodent uterus.
D000375:Aging; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003600:Cytosol / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D004958:Estradiol / Q000378:metabolism; D004967:Estrogens / Q000502:physiology*; D005260:Female; D007700:Kinetics; D010052:Ovariectomy; D012319:RNA Polymerase II / Q000378:metabolism; D051381:Rats; D011960:Receptors, Estrogen / Q000378:metabolism; D014599:Uterus / Q000502:physiology*
D004967:Estrogens; D011960:Receptors, Estrogen; D004958:Estradiol; D012319:RNA Polymerase II