Nephropathy induced in a nephritis-resistant inbred mouse strain with the use of a cationized antigen.
C3H/HeN mice produce small amounts of antibody when challenged daily with 4 mg horse spleen apoferritin and fail to develop significant renal histologic and immunohistologic lesions. When the same dose of antigen is given in cationized form, glomerular deposits of both antigen and IgG, often accompanied by C3, are uniformly found in all animals. Thus it appears that cationized antigens can induce the formation of potentially damaging immune complexes in low-antibody-producing individuals that are not ordinarily susceptible to this kind of immune injury.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D001052:Apoferritins / Q000008:administration & dosage* / Q000276:immunology / Q000494:pharmacology; D002196:Capillaries / Q000378:metabolism; D002412:Cations; D003176:Complement C3 / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005293:Ferritins / Q000031:analogs & derivatives*; D005455:Fluorescent Antibody Technique; D005920:Glomerular Mesangium / Q000378:metabolism; D005921:Glomerulonephritis / Q000209:etiology*; D006651:Histocytochemistry; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H
D000906:Antibodies; D000936:Antigen-Antibody Complex; D002412:Cations; D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005293:Ferritins; D001052:Apoferritins