Immunofluorescence studies of florid rheumatic Aschoff lesions.
We studied cardiac tissues of a patient who died of severe rheumatic myocarditis. Multiple Aschoff lesions were present throughout both ventricles and auricles. Immunofluorescence studies showed large monocytoid cells staining with OKM1 and anti-Leu M-3 as well as anti-Ia. Scattered T cells in areas of focal myocarditis stained with OKT3. Parallel staining for cardiac myosin-heavy chain antigens showed patchy dissolution of cardiac muscle fibers and traces of cardiac myosin within large monocytoid Aschoff cells.
D000328:Adult; D000911:Antibodies, Monoclonal; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D009205:Myocarditis / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D012214:Rheumatic Heart Disease / Q000473:pathology*; D012215:Rheumatic Nodule / Q000276:immunology / Q000473:pathology*
D000911:Antibodies, Monoclonal