title: The isolation and nucleotide sequence of the complex AROM locus of Aspergillus nidulans.
abstract: The AROM locus of A. nidulans, which governs five consecutive steps in pre-chorismate aromatic amino acid biosynthesis, has been cloned in a bacteriophage vector. The nucleotide sequence of the locus reveals a single, open reading-frame of 4,812 base-pairs, apparently without introns. An internal segment of the A. nidulans AROM sequence has extensive homology with the E. coli aroA gene that encodes the 5-enolpyruvylshikimate 3-phosphate synthase.
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000235:genetics*; D001233:Aspergillus nidulans / Q000235:genetics*; D001483:Base Sequence; D005075:Biological Evolution; D002827:Chorismic Acid / Q000096:biosynthesis*; D003001:Cloning, Molecular; D003062:Codon; D003509:Cyclohexanecarboxylic Acids / Q000096:biosynthesis*; D004271:DNA, Fungal / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics; D005800:Genes, Fungal
chemical_list: D000596:Amino Acids; D003062:Codon; D003509:Cyclohexanecarboxylic Acids; D004271:DNA, Fungal; D002827:Chorismic Acid