title: Insulin-like growth factors (IGF I and IGF II) mimic the effect of insulin on plasma protein synthesis and glycogen deposition in cultured hepatocytes.
abstract: Monolayer cultures of chick embryo hepatocytes were used to compare the effects of insulin-like growth factors, IGF I and IGF II, with insulin on two hepatic functions: plasma protein production and glycogen deposition. Just as with exposure of the cells to insulin, addition of either IGF I or IGF II to the otherwise hormone-free medium elicited a dramatic change in the production of secretory proteins as well as the development of glycogen deposits equivalent to in vivo (fed) levels. No major differences between insulin, IGF I or IGF II were observed in terms of the degree of stimulation or potency of the hormones.
mesh_terms: D000418:Albumins / Q000378:metabolism; D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis*; D002478:Cells, Cultured; D002642:Chick Embryo; D006466:Hemopexin / Q000378:metabolism; D007123:Immunoelectrophoresis, Two-Dimensional; D007328:Insulin / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism*; D008854:Microscopy, Electron; D013002:Somatomedins / Q000494:pharmacology*
chemical_list: D000418:Albumins; D001798:Blood Proteins; D007328:Insulin; D008112:Liver Glycogen; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D006466:Hemopexin