Increased basal gluconeogenesis in the aged rat.
Post-absorptive gluconeogenesis from lactate measured in vivo increases 3-fold in 24-month-old rats compared to 3-month-old animals. Fractional lactate turnover rates showed no significant differences between the two groups of animals. Lower plasma glucose concentrations and insulin-glucagon ratios may explain the increase in gluconeogenesis observed in aged rats.
D000375:Aging; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005934:Glucagon / Q000097:blood; D005943:Gluconeogenesis; D006003:Glycogen / Q000378:metabolism; D007328:Insulin / Q000097:blood; D007700:Kinetics; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D007328:Insulin; D007773:Lactates; D019344:Lactic Acid; D006003:Glycogen; D005934:Glucagon