Retinal toxicity of trace elements.
Acute toxicity of lead, nickel and cobalt on rabbit retina was studied. It was found that all these metals produced similar photoreceptor degenerative changes, but lead produced extensive degenerative changes at ganglion cell layer also. Electroretinographically nickel group showed statistically (by analysis of variance) significant prolongation of 'b' wave implicit time as seen in autosomal dominant retinitis pigmentosa.
D000818:Animals; D003035:Cobalt / Q000633:toxicity; D007854:Lead / Q000633:toxicity; D009532:Nickel / Q000633:toxicity; D011817:Rabbits; D012160:Retina / Q000187:drug effects*; D014131:Trace Elements / Q000633:toxicity*
D014131:Trace Elements; D007854:Lead; D003035:Cobalt; D009532:Nickel