Analysis of the antibody response developing in an infant with Candida albicans meningitis.
A case of meningitis due to Candida albicans in a neonate is described. This is the first report of an immunoblot analysis of both serial samples of serum and cerebrospinal fluid in relation to C. albicans antigens. The western blot technique demonstrated that the mother had IgM antibody against five candidal antigens, including one of molecular weight 47 kDaltons, but only a small amount of IgG antibody against two antigens of molecular weight 104 kDaltons and 60 kDaltons respectively. The baby produced IgM antibody and then IgG antibody against an antigen of 47 kDaltons molecular weight, and this was associated with recovery.
D000908:Antibodies, Fungal / Q000096:biosynthesis*; D000946:Antigens, Fungal / Q000276:immunology; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007231:Infant, Newborn; D008581:Meningitis / Q000209:etiology / Q000276:immunology*; D008970:Molecular Weight
D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D007074:Immunoglobulin G; D007075:Immunoglobulin M