title: 2-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) selectively antagonises N-methyl-aspartate (NMA).
abstract: Using electrophoretic application to rat central neurones in vivo, and bath application to frog spinal cord in vitro, 2-methyl-3,3-diphenyl-3-propanolamine was found to be a selective antagonist of N-methyl-DL-aspartate, but not of quisqualate or kainate. In this respect the (-) isomer proved to be about three times more potent than the (+) in both preparations.
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D000778:Anesthetics, Dissociative / Q000494:pharmacology*; D000818:Animals; D001001:Anura; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000494:pharmacology; D007649:Ketamine / Q000494:pharmacology; D008526:Medulla Oblongata / Q000166:cytology; D016202:N-Methylaspartate; D009474:Neurons / Q000187:drug effects*; D010069:Oxadiazoles / Q000037:antagonists & inhibitors; D010665:Phenylpropanolamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D016318:Quisqualic Acid; D051381:Rats; D013116:Spinal Cord / Q000166:cytology
chemical_list: D000777:Anesthetics; D000778:Anesthetics, Dissociative; D010069:Oxadiazoles; D001224:Aspartic Acid; C041058:2-methyl-3,3-diphenyl-3-propanolamine; D010665:Phenylpropanolamine; D016202:N-Methylaspartate; D007649:Ketamine; D016318:Quisqualic Acid; D007608:Kainic Acid