Relation of serum antibody to glycoproteins of respiratory syncytial virus with immunity to infection in children.
Immunity in relation to passively transferred maternal and naturally-induced serum antibody to the viral proteins was determined in 34 children who were followed from birth through three years of age for respiratory syncytial virus infection (RSV). Sera were tested by immunoglobulin class-specific enzyme-linked immunosorbent assay using the attachment and fusion proteins of the Long strain. The basis for immunity for maternal antibody in primary infection was assessed by a comparison of the distribution of antibody titers in a) 7 children who had an upper respiratory illness to 12 whose illness was accompanied by lower respiratory disease and of b) 13 children with an RSV-associated illness in the first 6 months of life who were age-matched as to month and approximate day of birth with 11 not infected in the same period. Infection induced immunity was evaluated by a comparison of antibody titers in 19 children who were reinfected with RSV in the year following their primary infection to 15 in whom reinfection was not documented. A statistical analysis of titers revealed that antibody to the fusion protein is an important correlate of immunity. In all three comparisons, the children with less RSV disease had significantly higher IgG anti-F titers prior to infection. No differences were observed between IgA anti-F or IgG and IgA anti-G titers.
D000917:Antibody Formation; D002675:Child, Preschool; D006801:Humans; D007113:Immunity, Innate; D007112:Immunity, Maternally-Acquired; D007132:Immunoglobulin Isotypes / Q000032:analysis; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D010253:Respirovirus Infections / Q000097:blood / Q000276:immunology*; D013997:Time Factors; D014760:Viral Fusion Proteins / Q000097:blood / Q000276:immunology*
D007132:Immunoglobulin Isotypes; D014760:Viral Fusion Proteins