title: Synthesis and antinociceptive activity of dezocine degradation products.
abstract: Three degradation products of dezocine were synthesized and tested for possible antinociceptive activity. 13-Amino-5,6,7,8,9,10-hexahydro-5-methyl-5,11-methanobenzocyclodecen+ ++-3-ol demonstrated antinociceptive properties comparable to morphine.
mesh_terms: D000700:Analgesics / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic; D055598:Chemical Phenomena; D002621:Chemistry; D003516:Cycloparaffins / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D013055:Spectrophotometry, Infrared; D013764:Tetrahydronaphthalenes
chemical_list: D000700:Analgesics; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003516:Cycloparaffins; D013764:Tetrahydronaphthalenes; C010827:dezocine