[Aldosterone content and renin activity in the plasma of hypothyroidism patients before and during treatment with thyroid preparations].
A study was made of aldosterone (A) level and plasma renin activity (PRA) in 47 patients with hypothyrosis of various degree of severity prior to and during therapy with thyroid drugs. A normal basal A level in the blood plasma was noted, in some patients it was raised or lowered. The following tendency was revealed during therapy with thyroid drugs: in patients with lowered A and PRA levels a rise of these levels was noted during treatment, in raised levels a significant drop was noted. Normal A and PRA basal levels (in most of the patients) showed in the process of treatment diverse tendencies: toward a decrease in the A level and a rise of the PRA level within normal range. The results obtained indicated independent effect of thyroid hormones on A and PRA synthesis. In case of low level of endogenous thyroid hormones as well as exposure to exogenous thyroid hormones changes in the A level were not directly controlled by PRA.
D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood*; D005260:Female; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008597:Menstrual Cycle; D008875:Middle Aged; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood*; D013963:Thyroid Hormones / Q000627:therapeutic use*; D013997:Time Factors; D014284:Triiodothyronine / Q000627:therapeutic use*
D006728:Hormones; D013963:Thyroid Hormones; D014284:Triiodothyronine; D000450:Aldosterone; C004227:thyroidin; D012083:Renin
Soderzhanie al'dosterona i aktivnost' renina v plazme bol'nykh gipotireozom do i v protsesse lecheniia tireoidnymi preparatami.