Vasoactive intestinal polypeptide immunopositive neurons in the paraventricular nucleus of homozygous Brattleboro rats.
Colchicine treatment reveals a population of vasoactive intestinal polypeptide (VIP) positive cell bodies in the hypothalamic paraventricular nucleus (PVN) of the vasopressin-deficient Brattleboro rat. These immunoreactive perikarya in the PVN cannot be detected in colchicine-treated Long-Evans animals. When Brattleboro rats are administered vasopressin, there is a significant decrease in the number of VIP-immunopositive cell bodies in the PVN. Evidently, an alteration in the synthesis and/or release of VIP occurs in the absence of the antidiuretic hormone.
D000818:Animals; D007124:Immunoenzyme Techniques; D008297:Male; D009474:Neurons / Q000032:analysis* / Q000145:classification; D010286:Paraventricular Hypothalamic Nucleus / Q000032:analysis*; D051381:Rats; D011910:Rats, Brattleboro; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014660:Vasoactive Intestinal Peptide / Q000032:analysis* / Q000276:immunology
D014660:Vasoactive Intestinal Peptide