[Immunodiagnostic studies in ovarian cancer using the leukocyte adherence inhibition test (LAI test). 1. Detection of cellular sensitization of peripheral blood lymphocytes using the LAI test].
34 patients with histological assured ovarian cancer were investigated with the direct chamber LAI-assay according to Halliday and Miller. As antigens we used KCl-extracts of ovarian cancer, fetal tissue and four other tumor associated antigens, A sensitivity of lymphocytes to ovarian cancer antigens (OCA) and fetal antigens (FA) was detected in the malignant group with significant differences p less than 0.0005 to the control group. The accuracy for OCA was 86% respectively 82% for FA. The LAI-assay has additional value for diagnosing of ovarian cancer. Difficulties in interpreting the individual LAI-assays results as well as false positive tests in the control group are discussed.
D000328:Adult; D000951:Antigens, Neoplasm / Q000276:immunology; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007158:Immunologic Techniques; D007957:Leukocyte Adherence Inhibition Test; D007958:Leukocyte Count; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000951:Antigens, Neoplasm; C017589:ovarian tumor associated antigen
Immundiagnostische Untersuchungen beim Ovarialkarzinom mit dem Leukozytenadhärenzinhibitionstest (LAI-Test). 1. Mitteilung: Nachweis einer zellulären Sensibilisierung an Lymphozyten des peripheren Blutes mit Hilfe des LAI-Tests.