Non-Hodgkin's lymphoma following Hodgkin's disease. A case report and immunohistochemical corroboration.
Two non-Hodgkin's lymphomas, one a follicular mixed cell type and the other a diffuse large cell type (Working Formulation), appeared 7 and 12 years, respectively, after the initial histopathologic diagnosis of Hodgkin's disease (nodular sclerosis) in an elderly male. The clinicopathologic implications of non-Hodgkin's lymphoma complicating Hodgkin's disease as a second malignant neoplasm are discussed on the basis of immunohistochemical studies performed on the sequentially biopsied lymph nodes using various monoclonal antibodies, in particular, anti-Leu-M1, which is known as a valuable marker of the neoplastic cells of Hodgkin's disease.
D000911:Antibodies, Monoclonal; D006689:Hodgkin Disease / Q000150:complications* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D000911:Antibodies, Monoclonal