title: Changes of endogenous prostacyclin-level in different experimental gastroduodenal ulcer models of rat.
abstract: It seems that the gastric antral mucosa either in normal, physiological circumstances, or in IND or STR induced gastric ulcer models, contains significantly more endogenous PG-I2 than that of gastric fundic mucosa, while the duodenal mucosa contains significantly lower endogenous PG-I2-level compared to the gastric antral or fundic level. Either in gastric or in duodenal ulceration the endogenous PG-I2 level basically decreased proportionally to the degree of ulceration - therefore it is tempting to speculate that the endogenous PG-I2 is most probably one of the natural protective substances in the gastrointestinal mucosa.
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D003543:Cysteamine; D011464:Epoprostenol / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D007213:Indomethacin / Q000633:toxicity*; D010437:Peptic Ulcer / Q000139:chemically induced / Q000209:etiology / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000150:complications
chemical_list: D011453:Prostaglandins; D015121:6-Ketoprostaglandin F1 alpha; D003543:Cysteamine; D011464:Epoprostenol; D007213:Indomethacin