title: Cellular immune mechanisms in thermally injured mice.
abstract: An attempt was made to establish an animal model for analysing the cellular immune alterations following thermal injury and to correlate the results with those obtained in humans. A standard burn involving 20 per cent of the body surface area was established in C57 black mice (b1). The results revealed a loss of total T cells until post-burn day 10 and an increase in B cells only during post-burn day 1. The lymphocyte proliferative response to PHA was elevated with the appearance of null cells on post-burn day 10. This observation revealed a generalized depression in the immune responses which was significant until post-burn day 10. However, the results were not comparable with the human studies.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002056:Burns / Q000276:immunology*; D004195:Disease Models, Animal; D006462:Hemolytic Plaque Technique; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology