The influence of a block copolymer on the efficiency of interfacial microencapsulation.
Both the presence of poloxamer in concentrations from 1 to 100 per cent w/v and variation in non-aqueous phase ratio in the range 0.2 to 2.0 influence the extent to which acetanilide is incorporated into piperazine arabate microcapsules compared to acetanilide encapsulation without polymer. Low poloxamer concentrations and phase ratios nearly double the amount of acetanilide encapsulated, but high concentrations or phase ratios or both decrease the efficiency of incorporation.
D000083:Acetanilides / Q000008:administration & dosage; D004339:Drug Compounding; D011060:Poloxalene / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology*
D000083:Acetanilides; D011092:Polyethylene Glycols; D011060:Poloxalene