Sustained release tablets based on chitosan and carboxymethylcellulose sodium.
Chitosan and mixtures of chitosan with carboxymethylcellulose sodium (CMC-Na) were examined as vehicles for sustained release tablets of water-insoluble drugs. Prednisolone (PDS) was selected as a model of a water-insoluble drug for this study. Sustained release of PDS from tablets prepared by direct compression of chitosan and CMC-Na was demonstrated in model JP X fluids. Furthermore, the release rate of PDS could be controlled by changing the relative amounts of chitosan and CMC-Na, or the amount of PDS in the tablets, and by certain extra additives. Such chitosan/CMC-Na mixtures are a promising basis in the design of sustained release dosage forms of water-insoluble drugs.
D002266:Carboxymethylcellulose Sodium; D002626:Chemistry, Pharmaceutical; D002686:Chitin / Q000031:analogs & derivatives*; D048271:Chitosan; D003692:Delayed-Action Preparations; D007785:Lactose; D008747:Methylcellulose / Q000031:analogs & derivatives; D011239:Prednisolone / Q000008:administration & dosage; D012995:Solubility; D013607:Tablets
D003692:Delayed-Action Preparations; D013607:Tablets; D002686:Chitin; D008747:Methylcellulose; D048271:Chitosan; D011239:Prednisolone; D007785:Lactose; D002266:Carboxymethylcellulose Sodium