Abnormal respiratory epithelial ion transport in cystic fibrosis.
The respiratory epithelium of cystic fibrosis patients exhibits excessive sodium (and volume) absorption and an absence of chloride (and volume) secretion in response to usual stimuli. These abnormalities likely contribute to the pathophysiology of cystic fibrosis lung disease, and provide a rationale for a novel therapeutic approach to this problem.
D000818:Animals; D001692:Biological Transport; D001980:Bronchi / Q000378:metabolism* / Q000502:physiology; D003550:Cystic Fibrosis / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007477:Ions / Q000378:metabolism*; D013545:Sweat Glands / Q000378:metabolism; D014132:Trachea / Q000378:metabolism* / Q000502:physiology
D007477:Ions