title: Nomenclature for enkephalin degrading peptidases.
abstract: The use of trivial names for enkephalin degrading peptidases such as "aminoenkephalinase" and "carboxyenkephalinase" imply a specificity and cellular localization which is not inherent in any of the peptidases implicated in the degradation of endogenous enkephalins. Rather than name these enzymes on the basis of one of their many substrates, it is proposed that they be named according to their general reaction type. Such a nomenclature has already been proposed for the enkephalin degrading endopeptidase 24.11 given the trivial name "enkephalinase".
mesh_terms: D000626:Aminopeptidases / Q000378:metabolism; D000803:Angiotensin I / Q000378:metabolism; D001920:Bradykinin / Q000378:metabolism; D001921:Brain / Q000201:enzymology; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D004745:Enkephalins / Q000378:metabolism*; D015260:Neprilysin; D010447:Peptide Hydrolases / Q000378:metabolism*; D013379:Substrate Specificity; D009626:Terminology as Topic; D014018:Tissue Distribution
chemical_list: D004745:Enkephalins; D000803:Angiotensin I; D010450:Endopeptidases; D010447:Peptide Hydrolases; D000626:Aminopeptidases; C025579:enkephalin degrading enzyme; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; C100152:dipeptidyl peptidase III; D015260:Neprilysin; D001920:Bradykinin