Severe aplastic anemia associated with chronic mucocutaneous candidiasis. Immunologic and hematologic reconstitution after allogeneic bone marrow transplantation.
Chronic mucocutaneous candidiasis (CMC) is typically associated with the inability of T lymphocytes to proliferate and produce lymphokines in response to Candida antigen. A 7-year-old girl with CMC developed severe aplastic anemia and, after conditioning with cyclophosphamide, 200 mg/kg, underwent bone marrow transplantation from her HLA-identical sister. Engraftment was prompt and complete. The patient is surviving more than 3 years after transplantation with normal donor-derived hemopoiesis and immune function. Manifestations of CMC have resolved completely and she has not received antifungal therapy for more than 2 years.
D000741:Anemia, Aplastic / Q000150:complications* / Q000276:immunology / Q000628:therapy; D000917:Antibody Formation; D016026:Bone Marrow Transplantation; D002177:Candidiasis / Q000150:complications*; D002178:Candidiasis, Chronic Mucocutaneous / Q000150:complications* / Q000276:immunology / Q000628:therapy; D002648:Child; D005260:Female; D006410:Hematopoiesis; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008213:Lymphocyte Activation