Liver transplantation in dogs after 30 minutes of warm ischemia.
In order to investigate the applicability of liver transplantation after warm ischemia, a partial auxiliary auto-transplantation of the liver after 30 min of warm ischemia was carried out in 9 mongrel dogs. Among them, 6 dogs survived longer than 7 days. Liver functions, blood coagulability and histological changes were investigated before and after the transplantation. Serum GOT, LDH, and GPT levels were elevated immediately after transplantation, and returned to normal within a few days. Hemostatic tests also showed significant abnormalities after transplantation. Although PT and thrombotest became normal within a week, PTT and antithrombin III remained slightly abnormal for longer periods. Microscopically, vacuolization and degeneration of hepatocytes were observed after transplantation but they recovered completely within 4 weeks. Based on these results, it could be said that the livers subjected to warm ischemia for 30 min ischemia were still acceptable for auxiliary transplantation.
D000818:Animals; D001780:Blood Coagulation Tests; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D004285:Dogs; D004798:Enzymes / Q000097:blood; D006487:Hemostasis; D007511:Ischemia; D008099:Liver / Q000098:blood supply / Q000473:pathology; D008111:Liver Function Tests; D016031:Liver Transplantation; D013696:Temperature; D013997:Time Factors; D014182:Transplantation, Autologous
D004798:Enzymes