Effect of saliva and serum on the adherence of Candida species to chlorhexidine-treated denture acrylic.
The effect of saliva and serum on the adherence of five strains of Candida albicans and one each of C. tropicalis and C. glabrata to chlorhexidine-pretreated acrylic was measured in vitro. A four-fold dilution of saliva or serum significantly inactivated the fungicidal effect of chlorhexidine gluconate. Pretreatment of the acrylic with unstimulated mixed saliva for 30 min led to a reduced adherence for all the Candida strains tested, whilst a similar pretreatment with serum slightly increased adhesion. Moreover treatment of saliva- or serum-coated acrylic with chlorhexidine gluconate 2% reduced adherence by between 19% and 86%. The inhibition of yeast adherence by chlorhexidine persisted for up to 19 days after the exposure of the acrylic strips to the disinfectant.
D000268:Adhesiveness; D001790:Blood Physiological Phenomena; D002175:Candida / Q000187:drug effects / Q000502:physiology*; D002176:Candida albicans / Q000187:drug effects / Q000502:physiology; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003819:Denture Bases; D006801:Humans; D020366:Methylmethacrylate; D008768:Methylmethacrylates; D012463:Saliva / Q000502:physiology*; D013997:Time Factors
D008768:Methylmethacrylates; D020366:Methylmethacrylate; C010882:chlorhexidine gluconate; D002710:Chlorhexidine