[Prostacyclin- and thromboxane synthesis in the vascular wall after gammatron irradiation].
One year aged rabbits were exposed to a single dose of 100, 500 or 1000 rd (1.0, 5.0 or 10 Gy) to the abdominal aorta. The non-irradiated thoracic aortic segment served as control. The animals were killed between one and 336 hours after the irradiation. Four animals were examined in each group. The prostacyclin formation was assessed by means of a radioimmunoassay against its stable breakdown 6-oxo-PGF1 alpha, the thromboxane A2-formation using a radioimmunoassay for thromboxane B2. Local irradiation causes a temporary increase of both the compounds. In contrast to thromboxane B2, the 6-oxo-PGF1 alpha exhibits a long-lasting depression. The higher the radiation dose, the more intensive the increase and the long-lasting depression of 6-oxo-PGF1 alpha. The liberation of eicosanoids and subsequent hemostatic dysregulation at different intervals after irradiation might contribute to an important extent to the radiation induced vasculopathy.
D000818:Animals; D001012:Aorta, Abdominal / Q000378:metabolism / Q000528:radiation effects; D001808:Blood Vessels / Q000378:metabolism / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D011464:Epoprostenol / Q000096:biosynthesis* / Q000528:radiation effects; D008297:Male; D011460:Prostaglandins F / Q000096:biosynthesis / Q000528:radiation effects; D011817:Rabbits; D011833:Radiation Injuries, Experimental; D013928:Thromboxane A2 / Q000096:biosynthesis* / Q000528:radiation effects; D013929:Thromboxane B2 / Q000096:biosynthesis* / Q000528:radiation effects; D014652:Vascular Diseases / Q000209:etiology
D011460:Prostaglandins F; D013929:Thromboxane B2; D013928:Thromboxane A2; D011464:Epoprostenol
Prostacyclin- und Thromboxansynthese der Gefässwand nach Gammatronbestrahlung.