Combined mutagenicity of cobalt(II) salt and heteroaromatic compounds in Salmonella typhimurium.
Mutagenic activities of 4-aminopyridine (4AP), 4-aminoquinoline (4AQ), 9-aminoacridine (9AA) and harman (HM) were examined by the Salmonella test system in the presence of cobalt(II) chloride (CoCl2), which itself is non-mutagenic in this system. Mutagenic activity of the mixture of 9AA and CoCl2 was found to be much higher than that of 9AA alone in strains TA1537 and TA2637. A similar enhancing phenomenon was observed in 4AQ-CoCl2 and HM-CoCl2 mixtures but not in that of 4AP-CoCl2. Judging from visible and nuclear magnetic resonance spectral data, this increased mutagenicity may be attributable to the formation of moderate to weak complexes between these chemicals and the Co(II) cation. A survey of the mutagenicity of several Co(II) complexes supported this interpretation.
D003035:Cobalt / Q000494:pharmacology*; D004357:Drug Synergism; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012486:Salmonella typhimurium / Q000187:drug effects*
D006571:Heterocyclic Compounds; D003035:Cobalt; C018021:cobaltous chloride