Skin cancer in the elderly.
This article discusses the relation between aging and development of nonmelanoma skin cancer. Possible age-related risk factors for development of such cancers are cumulative exposure to ultraviolet irradiation from the sun, decreased DNA repair capacity, decreased immunosurveillance, reduced melanocyte density, and altered dermal matrix. Clinical features of basal-cell carcinoma, squamous-cell carcinoma, and keratoacanthoma are discussed.
D000368:Aged; D000375:Aging; D002280:Basal Cell Carcinoma / Q000209:etiology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology; D004260:DNA Repair / Q000528:radiation effects; D006801:Humans; D007636:Keratoacanthoma / Q000209:etiology / Q000473:pathology; D008875:Middle Aged; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects