title: Study of the amniotic fluid from smokers and non-smokers in the Ames test.
abstract: Amniotic fluid from smokers and non-smokers was tested by the Salmonella/mammalian microsome test. Concentrated amniotic fluid from heavy smokers at term showed an increase in the number of revertants with increasing exposure to tar. However, some of the non-smokers had a higher number of revertants than the smokers. No significant differences were found between second-trimester samples from smokers and non-smokers, but the limited volumes available at this stage of pregnancy may be a source of error.
mesh_terms: D000328:Adult; D000367:Age Factors; D000653:Amniotic Fluid / Q000032:analysis*; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis* / Q000378:metabolism; D010298:Parity; D011247:Pregnancy; D012486:Salmonella typhimurium / Q000187:drug effects; D012907:Smoking
chemical_list: D009153:Mutagens