Regulation of the synthesis of lipoprotein lipase in adipose tissue by dexamethasone.
The incorporation of [3H]leucine into lipoprotein lipase during incubations of rat epididymal fat-bodies in vitro was significantly stimulated by dexamethasone, whereas total protein synthesis was unaffected. The stimulation by dexamethasone required the presence of insulin. The results suggest that dexamethasone, in the presence of insulin, may specifically induce lipoprotein lipase synthesis in adipose tissue.
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel; D007328:Insulin / Q000494:pharmacology; D007930:Leucine / Q000378:metabolism; D008071:Lipoprotein Lipase / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D003907:Dexamethasone; D008071:Lipoprotein Lipase; D007930:Leucine