The susceptibility of Cryptococcus neoformans to an antimycotic agent (G2) from alfalfa.
Compound G2, 2-beta-hydroxy-3-beta-O-(beta-D-glucopyranosyl)-delta 12-oleanene-23,28-dionic acid, isolated from alfalfa roots, demonstrated considerable activity against Cryptococcus neoformans (MIC value of 2 micrograms/ml). Compound G2 exhibited rapid killing of this fungus (MFC value of 4 micrograms/ml) suggesting that it might be a useful active agent in the treatment of cryptococcosis.
D000935:Antifungal Agents / Q000494:pharmacology*; D003454:Cryptococcus / Q000187:drug effects*; D003455:Cryptococcus neoformans / Q000187:drug effects*; D007700:Kinetics; D000455:Medicago sativa; D010936:Plant Extracts / Q000494:pharmacology; D012503:Saponins / Q000494:pharmacology*; D014315:Triterpenes / Q000494:pharmacology*
D000935:Antifungal Agents; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C049077:medicagenic acid-3-O-glucopyranoside