Changes in specialized cognitive function following changes in hormone levels.
Increase of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in men by injection of luteinizing hormone releasing hormone (LHRH) prevented improvement in a spatial orientation test relative to a placebo condition. By contrast, performance on a fluency task was significantly increased after LHRH injection relative to the placebo condition. These data support between-subject results where FSH was negatively correlated with visuospatial skills and positively correlated with fluency. There was no change in cognitive function in males following injection of testosterone. There were also no fluctuations in cognitive function that coincided with hormonal fluctuations of the menstrual cycle in women.
D000293:Adolescent; D000328:Adult; D003071:Cognition / Q000187:drug effects / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D008297:Male; D008597:Menstrual Cycle; D009483:Neuropsychological Tests; D013739:Testosterone / Q000031:analogs & derivatives / Q000494:pharmacology; D014705:Verbal Behavior / Q000502:physiology
D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; C004648:testosterone enanthate