Protective effect of theophylline on histamine-induced bronchoconstriction in asthmatic children.
The bronchial responsiveness of a group of asthmatic children was studied using histamine stimulation after a single dose of theophylline and after placebo. Theophylline, when levels were greater than 10 micrograms ml-1 significantly reduced responsiveness but only by just over one doubling concentration of histamine (P less than 0.001).
D000293:Adolescent; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D010366:Peak Expiratory Flow Rate; D013806:Theophylline / Q000097:blood / Q000494:pharmacology*
D006632:Histamine; D013806:Theophylline