Abdominal heart transplantation: description of a new allograft extrathoracic pump.
This study describes a new kind of abdominal heart transplantation for left ventricular assistance carried out in a series of 12 experiments in pigs weighing 15-25 kg. This was achieved making three connections between the donor's left atrium, aorta and pulmonary artery with the recipient's aorta, still aorta and inferior vena cava, respectively. The hemodynamic data were satisfactory, the best survival rate with a transplanted working heart was 1 month. The low output of the recipient's left ventricle was obtained by ligation of the left anterior descending (LAD) coronary artery. In all animals, the highest peak of the pressure of the transplanted left ventricle was at least 20 mm Hg higher (ranging from 20 to 60 mm Hg) than the pressure in the recipient's left ventricle, and corresponded with the peak of the systemic arterial pressure. The cardiac output of the transplanted hearts showed a good hemodynamic response with support of the circulation after ligation of the LAD coronary artery in the recipient's heart.
D000005:Abdomen; D000818:Animals; D001011:Aorta / Q000601:surgery; D001012:Aorta, Abdominal / Q000601:surgery; D001794:Blood Pressure; D002302:Cardiac Output; D006084:Graft Rejection; D016027:Heart Transplantation; D006439:Hemodynamics; D011183:Postoperative Complications; D011651:Pulmonary Artery / Q000601:surgery; D013552:Swine; D014682:Vena Cava, Inferior / Q000601:surgery; D014693:Ventricular Fibrillation / Q000209:etiology