Trypsin-sensitive plasmodia in the liver of post-infection rats and rhesus monkeys.
Kupffer cells from the liver and erythrocytes from peripheral blood were collected at the post-patent period from albino rats infected earlier with Plasmodium berghei and rhesus monkeys infected earlier with P. cynomolgi var. bastianelli or P. knowlesi. The cells were subinoculated into individual normal recipients. These recipients subsequently showed parasitaemia in their circulation. The parasites present in Kupffer cell preparations were found to be sensitive to trypsin treatment, while those in erythrocytes were found to be resistant to trypsin treatment. This differential sensitivity of parasites to trypsin was observed in all the three species of plasmodia studied so far.
D000818:Animals; D004912:Erythrocytes / Q000469:parasitology*; D007728:Kupffer Cells / Q000469:parasitology*; D008253:Macaca mulatta; D008288:Malaria / Q000469:parasitology*; D008297:Male; D010961:Plasmodium / Q000187:drug effects*; D010962:Plasmodium berghei / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014357:Trypsin / Q000494:pharmacology*
D014357:Trypsin