Antibody-dependent and -independent cytotoxic activity of spleen cells for Plasmodium berghei from susceptible and resistant rats.
Antibody-dependent cell cytotoxicity (ADCC) mediated by spleen cells from 30- or 50-day old rats against 51Cr-labelled rat erythrocytes parasitized by Plasmodium berghei in the presence of anti-P. berghei antibody showed only slight age differences. However, in the absence of specific antibody, the total cell-mediated cytotoxicy (CMC) per spleen was four times higher in the spleen cells from 50-day-old rats compared with those from 30-day-old rats. CMC accounted for about 50% of total cytotoxic activity in 50-day-old rat spleens. Spleen cells mediating ADCC and CMC are Thy-1.1 positive, and those mediating ADCC are nearly all non-adherent to Sephadex G-10 columns.
D000375:Aging; D000818:Animals; D000917:Antibody Formation; D000920:Antibody-Dependent Cell Cytotoxicity; D003602:Cytotoxicity, Immunologic; D004198:Disease Susceptibility; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007113:Immunity, Innate; D007074:Immunoglobulin G / Q000276:immunology; D008288:Malaria / Q000276:immunology*; D010962:Plasmodium berghei / Q000276:immunology*; D051381:Rats; D013154:Spleen / Q000276:immunology*
D007074:Immunoglobulin G