Polyamines.
Putrescine, spermidine, spermine and their derivatives are considered to be potential markers of certain diseases. Routine methods have, therefore, been developed in the course of the last decade. Several automated liquid chromatographic and gas chromatographic methods are presently at our disposal, which meet the practical requirements of sensitivity and specificity. They make the routine application of gas chromatographic-mass spectrometric methods dispensable. Very recently the amino acids deriving from polyamines have also been taken into consideration as tumour markers. Their separation by capillary gas chromatography has been reported. Separation of ion pairs on reversed-phase columns may also prove useful in the establishment of complete concentration profiles of polyamines and their derivatives in tissues and body fluids.
D000818:Animals; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D002854:Chromatography, Paper; D002855:Chromatography, Thin Layer; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D011073:Polyamines / Q000032:analysis*
D011073:Polyamines