title: [Osteoid induction].
abstract: Osteoinduction is a biological principle. The implantation of tissue with inductive properties results in the proliferation and differentiation of undifferentiated cells to cartilage and bone. This process, which is similar to a cascade-type mechanism, is controlled by a series of humoral and local growth factors. It was possible to isolate a number of macromolecular substances with osteoinductive, mitogenic, or chemotactic properties specifically from the extracellular bone matrix. A deeper understanding of the regulative mechanisms as well as the greater availability of growth factors may lead to new therapeutic approaches in bone surgery.
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins; D001861:Bone Regeneration; D016025:Bone Transplantation; D005615:Freezing; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D007335:Insulin-Like Growth Factor II; D010012:Osteogenesis; D011506:Proteins / Q000502:physiology; D014021:Tissue Preservation / Q000379:methods
chemical_list: D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; C035170:IGF2 protein, human; D011506:Proteins; D007335:Insulin-Like Growth Factor II
vernacular_title: Osteoinduktion.