Evaluation of the effects of vasoactive drugs on cutaneous microcirculation by laser Doppler velocimetry.
The effects provoked in different points of skin circulation by a vasoactive drug injected in the femoral artery of patients affected by chronic obliterative arterial disease at clinical stage 2, were evaluated using the laser Doppler velocimeter. At the same time, by means of strain gauge plethysmography, measurements were taken of the relative variations of volume and amplitude of the pulse waves in the hallux and of blood flow in the calf. After administration of the drug, a number of phenomena were observed, the most notable of which was a rapid and intense shift of blood from skin to muscle, followed by an increase in the global perfusion of the limb. Considering the physio-pathological importance of regional blood redistribution between skin and muscle and the high frequency rate of skin lesions in vascular diseases of the limbs, the possibility of evaluating, with a practical, non-invasive technique, the effects of drugs at the skin level is of great interest.
D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000188:drug therapy; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D007834:Lasers; D008297:Male; D008875:Middle Aged; D009257:Nafronyl / Q000008:administration & dosage; D012867:Skin / Q000187:drug effects; D014463:Ultrasonography; D014652:Vascular Diseases / Q000188:drug therapy; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents; D009257:Nafronyl