Comparative effects of indomethacin and proglumetacin on 6-oxo-PGF1 alpha released ex vivo by rat gastric mucosa.
The authors compare the effect of indomethacin and proglumetacin on the production of prostacyclin in the rat gastric mucosa, and investigate the potential ulcerogenic effect elicited by the two drugs. The results show that indomethacin and proglumetacin, at doses giving similar inhibition of gastric-protacyclin synthesis, drastically differ in their gastric ulcerogenic effects.
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism*; D000818:Animals; D011464:Epoprostenol / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D007210:Indoleacetic Acids / Q000494:pharmacology* / Q000633:toxicity; D007213:Indomethacin / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced*
D007210:Indoleacetic Acids; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol; C019541:proglumetacin; D007213:Indomethacin