title: Experimental proctitis due to rectal infection with Chlamydia trachomatis in nonhuman primates.
abstract: To serially examine the immunopathogenesis and histopathology of rectal infection with Chlamydia trachomatis, we inoculated five cynomolgus monkeys with C. trachomatis serovar E (non-LGV) and five with serovar L2 (LGV). After inoculation, C. trachomatis was isolated from rectal cultures in three of five non-LGV-infected monkeys and in all five LGV-infected monkeys for a period of 10 weeks. LGV-infected monkeys developed a severe hemorrhagic ulcerative proctitis, in contrast to a mild proctitis in the non-LGV-infected monkeys. Hyperplasia of lymphoid follicles and a mucosal polymorphonuclear leukocyte and mononuclear cell infiltrate were evident in all infected monkeys. Crypt abscesses with giant cells and a rare granuloma formation were present in two of five LGV-infected monkeys. C. trachomatis inclusions were initially present in epithelial cells and later in tissue histiocytes. Experimental primate infection with C. trachomatis appears to clinically and histopathologically mimic rectal infection in humans and provides a model for immunopathogenesis studies in chlamydial proctitis and granulomatous proctitis.
mesh_terms: D000818:Animals; D001706:Biopsy; D002692:Chlamydia trachomatis; D004195:Disease Models, Animal; D005260:Female; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D008219:Lymphogranuloma Venereum / Q000382:microbiology* / Q000473:pathology; D008252:Macaca fascicularis; D008297:Male; D011349:Proctitis / Q000382:microbiology* / Q000473:pathology; D012007:Rectum / Q000473:pathology