title: Clinical evaluation of endocervical prostaglandin E2-triacetin-gel for preinduction cervical softening in pregnant women at term.
abstract: In an open randomized clinical trial 100 pregnant women with low Bishop Scores at term were treated either with intracervical Prostaglandin (PG) E2 (0.5 mg in 2.5 ml triacetin-gel) 12 hours before labor induction with intravenous oxytocin or with oxytocin infusion alone. In 46 of the 50 pretreated patients (92%) the Bishop Score progressed at least 3 points, in four cases only 2 points. The mean Bishop score in the untreated patients increased insignificantly. After PGE2-gel administration 16 patients delivered during the 12 hour interval compared to 3 in the group without pretreatment. The first induction attempt was successful in 14 (64%) of the 22 patients that were left to be induced after cervical softening and in 26 (57%) of the 47 women without cervical priming. The Cesarean section rate was 10% (n = 5) in the PGE2-gel group and 12% (n = 6) in the control group. Dosage of oxytocin required for labor induction was significantly lower after cervical softening. No serious fetal or maternal side effects were observed after PGE2 pretreatment.
mesh_terms: D002584:Cervix Uteri / Q000187:drug effects* / Q000502:physiology; D002585:Cesarean Section; D002986:Clinical Trials as Topic; D004106:Dilatation / Q000379:methods; D015232:Dinoprostone; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D005782:Gels; D006801:Humans; D007751:Labor, Induced; D010121:Oxytocin / Q000627:therapeutic use*; D011247:Pregnancy; D011458:Prostaglandins E / Q000627:therapeutic use*; D014215:Triacetin / Q000627:therapeutic use*; D014280:Triglycerides / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D005782:Gels; D011458:Prostaglandins E; D014280:Triglycerides; D010121:Oxytocin; D015232:Dinoprostone; D014215:Triacetin