[Vasodilating effect of leukotriene C4 and D4 by stimulation of prostacyclin synthesis].
Since the original discovery and structural characterization of leukotrienes, these substances have attracted considerable interest due to their numerous biological activities. It is known that these substances exert a short lasting vasoconstrictory and a longer lasting vasodilatory response. However, the cause of this biphasic response is not clear as yet. Human coronary artery segments synthesize about 50 pg PGI2/cm2/min in vitro under pressure perfusion. At concentrations ranging from 1 to 100 ng leukotrienes C4 and D4 cause a dose-dependent increase in PGI2 generation. Inhibition by acetylsalicylic acid and 15-hydroxyperoxyarachidonic acid indicates the mechanism to be mediated via the cyclooxygenase. It is, therefore, concluded that the capacity of leukotrienes C4 and D4 to stimulate PGI2 formation might play a key role during acute inflammation at the site of white blood cell accumulation.
D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000096:biosynthesis*; D006801:Humans; D010477:Perfusion; D013189:SRS-A / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects*
D013189:SRS-A; D011464:Epoprostenol
Vasodilatierender Effekt von Leukotrien C4 und D4 durch Stimulation der Prostazyklinsynthese.