Decreased birth weight and femur length in fetuses of patients with the sickle-cell trait.
The mean birth weight in women with the sickle-cell trait (Hb-AS) was less than in a matched population (Hb-AA), and the difference was statistically significant. Ultrasonic fetal biparietal diameter measurements in 30 patients with Hb-AS fell within normal limits, but mean femur lengths were found to be reduced at each gestational period when compared with similar measurements in patients with normal hemoglobin.
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell; D001724:Birth Weight; D002508:Cephalometry; D005314:Embryonic and Fetal Development; D005260:Female; D005269:Femur / Q000196:embryology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011296:Prenatal Diagnosis; D012805:Sickle Cell Trait; D014463:Ultrasonography