Impairment of renal slice function following brain death, with reversibility of injury by hormonal therapy.
The effects of the agonal period and subsequent donor management on renal slice function, using the K+ - Na+ ratio, have been studied in the pig. Brain ischaemia or death resulted in a reduction in renal slice function, whether the pig was maintained normovolemic or hypovolemic by i.v. fluid and dobutamine therapy. This deterioration in function was, however, reversed or prevented by a period of therapy with thyroxine (T3), insulin, and cortisol. A period of 24 hr storage of the kidney slice in a low ionic strength solution in ice resulted in a further deterioration in slice function in all groups studied.
D000818:Animals; D001794:Blood Pressure; D001926:Brain Death / Q000503:physiopathology*; D002545:Brain Ischemia / Q000503:physiopathology; D003080:Cold Temperature; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D011188:Potassium / Q000032:analysis; D012964:Sodium / Q000032:analysis; D013552:Swine; D013974:Thyroxine / Q000494:pharmacology*; D014021:Tissue Preservation / Q000009:adverse effects
D007328:Insulin; D012964:Sodium; D013974:Thyroxine; D011188:Potassium; D006854:Hydrocortisone