[Expression of class I and class II markers on populations of leukemic cells].
The study of class I and class II antigen expression on leukemic cells brought the following conclusions: most of the leukemic cells show a slower number of class I antigenic sites than normal peripheral blood lymphocytes (PBL) but, in most cases, this does not hinder HLA typing; contrarily to normal PBL, leukemic cells seem to carry "non HLA" antigens (and/or non classical HLA antigens) which are probably responsible of the false positive reactions frequently observed at the time of HLA typing; most of the leukemic cell types express DR antigens (except those belonging to the T lineage) but DQ antigen expression (and in some cases MT antigen expression) varies depending on the cell type studied: well defined on mature B hemopathies, DQ expression is often lower than DR expression on acute leukemic cell types.
D006680:HLA Antigens / Q000032:analysis / Q000235:genetics*; D006681:HLA-D Antigens / Q000032:analysis / Q000235:genetics*; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000276:immunology
D006680:HLA Antigens; D006681:HLA-D Antigens; D006684:HLA-DR Antigens
Expression des marqueurs de classe I et II sur des populations de cellules leucémiques.