Effects of strontium on calcium-dependent hexose transport in muscle.
Hexose transport in isolated perifused rat and guinea pig left atria and in isolated intact rat hemidiaphragms was followed by measuring the tissue/medium distribution of the nonmetabolized glucose analog, 3-O-methyl-D-glucose. Stimulation of 3-methylglucose transport by insulin, hyperosmolar medium, K+-free medium, and ouabain was depressed or absent in Ca2+-free medium. Addition of 2 mM Sr2+ to Ca2+-free media restored the response of transport to the stimulatory factors. Sr2+ also increased basal hexose transport. The Ca2+ dependence and the effect of Sr2 was greatest in guinea pig atria and least in rat hemidiaphragms. It is concluded that Sr2+ plays a Ca2+-like role in the regulation of hexose transport.
D019325:3-O-Methylglucose; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology*; D003964:Diaphragm / Q000378:metabolism; D005711:Gallopamil / Q000494:pharmacology; D006168:Guinea Pigs; D006325:Heart Atria / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D007700:Kinetics; D008757:Methylglucosides / Q000378:metabolism*; D008759:Methylglycosides / Q000378:metabolism*; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D010042:Ouabain / Q000494:pharmacology; D013324:Strontium / Q000494:pharmacology*
D007328:Insulin; D008757:Methylglucosides; D008759:Methylglycosides; D019325:3-O-Methylglucose; D005711:Gallopamil; D010042:Ouabain; D002118:Calcium; D013324:Strontium