The ability of granulocytes from patients with atopy to engulf neutral latex particles and Staphylococcus aureus.
The granulocytes obtained from patients with atopic diseases were investigated for their ability to engulf neutral latex particles and bacteria (S. aureus) in the presence of antigenically compatible sera of healthy subjects. Similar tests were done using the granulocytes of healthy subjects and sera of the patients with atopic diseases, and the granulocytes of these patients in autologous sera. Granulocytes of healthy subjects suspended in autologous sera served as a control. In all patients IgE globulins were determined in the serum. It was observed that only granulocytes from the patients with atopy showed a defect in engulfing latex particles and S. aureus. This defect was independent of the serum in which these granulocytes were suspended, and of the IgE level in the patient's serum.
D000328:Adult; D000941:Antigens / Q000276:immunology; D001249:Asthma / Q000276:immunology; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007840:Latex; D010587:Phagocytosis; D013211:Staphylococcus aureus / Q000276:immunology*
D000941:Antigens; D007840:Latex