Influence of prostaglandin D2 on hemodynamic effects of group B streptococcus in neonatal lambs.
Infusions of group B streptococci cause pulmonary hypertension in several neonatal animal models. A continuous infusion of prostaglandin D2 reduced the magnitude of this pulmonary hypertensive response; indomethacin completely blocked the response. Prostaglandin D2 or cyclooxygenase inhibitors may be important therapeutic agents for infants with group B streptococcal sepsis who manifest pulmonary hypertension.
D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D007213:Indomethacin / Q000494:pharmacology; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000494:pharmacology*; D011652:Pulmonary Circulation / Q000187:drug effects*; D012756:Sheep; D013290:Streptococcal Infections / Q000503:physiopathology*; D013292:Streptococcus agalactiae; D014655:Vascular Resistance / Q000187:drug effects
D011457:Prostaglandins D; D015230:Prostaglandin D2; D007213:Indomethacin