Clinical and pharmacokinetic concerns of 24-hour dosing with theophylline.
Selection of the dosing interval for oral theophylline must consider the product's absorption rate, the patient's elimination rate, and the tolerated fluctuation in serum concentration. Attempts to produce formulations with ultra-slow absorption for "once daily" marketing have thus far resulted in incomplete and erratic absorption.
D000042:Absorption; D001249:Asthma / Q000188:drug therapy; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000627:therapeutic use; D006801:Humans; D007700:Kinetics; D013806:Theophylline / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use
D003692:Delayed-Action Preparations; D013806:Theophylline; D004837:Epinephrine