Role of arginine vasopressin in regulation of systemic arterial pressure.
Arginine vasopressin (AVP) not only influences renal water metabolism but also has profound cardiovascular effects. Physiologic levels of the hormone produce a pressor response in the basal state when vasoregulatory reflex mechanisms are interrupted. During hypovolemia, vasopressin affects systemic blood pressure independent of the renin-angiotensin system and efferent sympathetic pathways. Many studies implicate AVP in the pathogenesis of hypertension, but the actual mechanism and relative importance of vasopressin's role remain a matter of intense investigation.
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000494:pharmacology / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume; D004285:Dogs; D006439:Hemodynamics; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D006978:Hypertension, Renovascular / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D011311:Pressoreceptors / Q000502:physiology; D051381:Rats; D011910:Rats, Brattleboro; D011919:Rats, Inbred Strains; D012084:Renin-Angiotensin System
D001127:Arginine Vasopressin