Charge transfer-oxy radical mechanism for anticancer agents: mAMSA derivatives, rhodamine 123, and nickel salicylaldoximate.
The proposal is advanced that many anticancer agents may function via redox reactions resulting in generation of toxic oxy radicals which destroy neoplastic cells. Cyclic voltammetry was performed with some of the main types: iminium ions (protonated mAMSA derivatives), quinone derivatives (rhodamine 123) and metal complexes (nickel(II) salicylaldoximate). In addition, relevant literature data are provided. A rationale is offered that relates electrochemical data to physiological activity.
D000677:Amsacrine / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005609:Free Radicals; D009532:Nickel / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010091:Oximes / Q000494:pharmacology*; D011809:Quinones / Q000494:pharmacology; D020112:Rhodamine 123; D012235:Rhodamines / Q000494:pharmacology*; D014966:Xanthenes / Q000494:pharmacology*
D000970:Antineoplastic Agents; D005609:Free Radicals; D010091:Oximes; D011809:Quinones; D012235:Rhodamines; D014966:Xanthenes; D000677:Amsacrine; D020112:Rhodamine 123; C005704:salicylaldoxime; D009532:Nickel