title: [Determination of a factor inhibiting migration of leukocytes to brain antigens, its concentration in serum and spontaneous leukocyte migration in multiple sclerosis].
abstract: The authors examined 58 patients with multiple sclerosis and 56 healthy donors. The patients presented elevated production of the migration inhibition factor (MIF) by lymphoid cells to cerebral tissue antigens, most expressed in the acute period of the disease. The blood serum of patients with multiple sclerosis showed inhibitory activity, lymphocytes spontaneously produced the MIF in vitro. Hyperproduction of lymphokins may serve as one of the pathogenetic factors of generalization of the inflammatory process in the central nervous system in patients with multiple sclerosis and indicates impaired regulation of immunity.
mesh_terms: D001921:Brain / Q000276:immunology*; D002465:Cell Movement; D005260:Female; D006801:Humans; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis / Q000097:blood*; D007962:Leukocytes / Q000276:immunology* / Q000378:metabolism; D008222:Lymphokines / Q000097:blood*; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood / Q000276:immunology*
chemical_list: D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines
vernacular_title: Opredelenie faktora tormozheniia migratsii leĭkotsitov k tkanevym antigenam mozga, soderzhanie ego v syvorotke krovi i spontannaia migratsiia leĭkotsitov pri rasseiannom skleroze.