Effects of dobutamine on renal function in normal man.
The effects of graded doses of dobutamine on renal function were studied in eight male volunteers. The infusion rates were 2.5, 5 and 10 micrograms/kg/min. Systolic blood pressure increased by 19% (P less than 0.01), 31% (P less than 0.01), and 44% (P less than 0.01), respectively, while diastolic blood pressure decreased by 17% (P less than 0.02), 17% (P less than 0.02) and 25% (P less than 0.01), respectively. Heart rate increased at the highest dosage by 32% (P less than 0.01). Glomerular filtration rate (GFR) diminished at all three infusion speeds by 10% (P less than 0.02), 9% (P less than 0.05) and 14% (P less than 0.02), respectively, while renal blood flow (RBF) was unchanged. Urine flow rate (UF) decreased by 36% (P less than 0.05) and fractional free water clearance (CH2O/CIn) diminished by 37% (P less than 0.05) at the rate of 10 micrograms/kg/min. Fractional potassium excretion (CK/CIn) decreased by 34% (P less than 0.01) and 44% (P less than 0.01) at the two highest rates. Fractional sodium excretion (CNa/CIn) and fractional chloride excretion (CCl/CIn) were unchanged. Catecholamine levels were unaltered. Plasma renin activity (PRA) rose significantly (P less than 0.05) at the highest infusion rate of dobutamine. It is concluded that dobutamine influences GFR, the clinical significance of which, however, is difficult to evaluate.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000097:blood; D004280:Dobutamine / Q000008:administration & dosage / Q000494:pharmacology*; D004573:Electrolytes / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007263:Infusions, Parenteral; D007444:Inulin; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D008297:Male; D012083:Renin / Q000097:blood; D010130:p-Aminohippuric Acid
D002395:Catecholamines; D004573:Electrolytes; D004280:Dobutamine; D007444:Inulin; D012083:Renin; D010130:p-Aminohippuric Acid