[Immunohistochemical and ultrastructural characteristics of the bronchial mucosa in chronic inflammation].
The local immunity was studied using 31 biopsy samples obtained during bronchoscopy from patients with various forms of chronic bronchitis. Attenuated IgA synthesis by plasmatic cells of bronchial mucosa lamina propria and increased LgG synthesis were established. Enhanced IgG production and penetration of various agents into bronchial mucosa lamina propria cause local immunocomplex reaction involving microcirculatory bed and resulting in perivascular sclerosis. Repeated damaging and sclerotic processes lead to disconnection of epithelial-stromal links and altered cover epithelium differentiation. The role of immunopathologic reactions in the formation of vicious circle underlying morphogenesis of chronic bronchitis is suggested.
D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D001706:Biopsy; D001980:Bronchi / Q000276:immunology* / Q000378:metabolism / Q000648:ultrastructure; D001991:Bronchitis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D002908:Chronic Disease; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008854:Microscopy, Electron; D008875:Middle Aged; D009092:Mucous Membrane / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure
D000936:Antigen-Antibody Complex; D007136:Immunoglobulins
Immunogistokhimicheskaia i ul'trastrukturnaia kharakteristika slizistoĭ obolochki bronkhov pri khronicheskom vospalenii.