The role of interleukin-1 in neutrophil leukocyte emigration induced by endotoxin.
Chemotactic factors induce neutrophil emigration into tissues. Interleukin-1 (IL-1) was found to be several log times more potent in this respect than C5a des Arg, leukotriene B4, and f-Met-Leu-Phe and of comparable potency to endotoxin. Kinetic studies revealed a rapid and transient neutrophil influx, with the peak rate at 30-90 minutes. Cross tachyphylaxis was observed between IL-1 and endotoxin; and this, together with its high potency and rapid onset of action, suggest that IL-1 mediates endotoxin-induced neutrophil emigration.
D000818:Animals; D002630:Chemotactic Factors / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D007375:Interleukin-1 / Q000502:physiology*; D007700:Kinetics; D011817:Rabbits; D013618:Tachyphylaxis
D002630:Chemotactic Factors; D004731:Endotoxins; D007375:Interleukin-1