Recurrent varicella-zoster infection after acyclovir therapy in immunocompromised patients.
Varicella-zoster virus (VZV) infection is a late complication of bone marrow transplantation in almost half of the long-term survivors. We have reported the clinical relapse of VZV infection in two marrow transplant recipients treated with standard regimens of acyclovir, a new antiviral agent with activity against VZV. Since most VZV infections occur after discharge from a transplant center, primary care physicians must be alert to the possibility of relapse of VZV infection after acyclovir therapy.
D000212:Acyclovir / Q000627:therapeutic use*; D000293:Adolescent; D016026:Bone Marrow Transplantation; D006562:Herpes Zoster / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007108:Immune Tolerance; D007951:Leukemia, Myeloid / Q000150:complications; D008297:Male; D011183:Postoperative Complications; D012008:Recurrence
D000212:Acyclovir