[Effect of hydrocortisone on the osteogenetic function of the bone marrow of the mouse].
Bone marrow cells were implanted into the capsule of the kidney of mice which were then given intraperitoneal injections of hydrocortisone in the dose of 5 mg per animal. The drug influenced different stages of bone histogenesis in a different manner. The stage of the onset of bone formation proved to be most sensitive, whereas the earlier and later stages were less sensitive to hydrocortisone. It is concluded that the target cells for hydrocortisone are osteoblasts at the stage of active synthesis of bone proteins rather than cells-precursors of osteogenesis.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D016026:Bone Marrow Transplantation; D006824:Hybridization, Genetic; D006854:Hydrocortisone / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010006:Osteoblasts / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects*
D006854:Hydrocortisone
Vliianie gidrokortizona na kosteobrazovatel'nuiu funktsiiu kostnogo mozga mysheĭ.