Selection by site-directed antibodies of small regions of peptides which are ordered in water.
High resolution nuclear magnetic resonance has been used to study a short peptide which corresponds to the antigenic region of a larger peptide immunogen. This work shows that there is a strong conformational preference for a Type II beta-turn in solution. This observation has implications for the nature of the immunogenicity and antigenicity of peptide antigens as well as for the more general question of protein-folding mechanisms.
D000911:Antibodies, Monoclonal; D000941:Antigens; D001665:Binding Sites; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides / Q000276:immunology*; D011487:Protein Conformation; D014867:Water
D000911:Antibodies, Monoclonal; D000941:Antigens; D010455:Peptides; D014867:Water