Metabolism and transport of dehydroascorbic acid in erythrocytes of "spontaneous diabetic BB/W" Wistar rats.
Rates of uptake and reduction of dehydroascorbic acid in erythrocytes of "Spontaneous diabetic BB/W" and control Wistar rats were determined. Lysed cells reduced 14C-dehydroascorbic acid more rapidly than intact cells did, suggesting that membrane transport is a rate-limiting step. Diabetic rats had lower plasma levels of ascorbic acid but more rapid reduction of dehydroascorbic acid than control animals. The results indicate more rapid transport of dehydroascorbic acid into erythrocytes of prediabetic "BB/W" rats than Wistar rats.
D000818:Animals; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000097:blood; D001692:Biological Transport; D003683:Dehydroascorbic Acid / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D010084:Oxidation-Reduction; D051381:Rats; D011913:Rats, Inbred BB; D011919:Rats, Inbred Strains
D007328:Insulin; D001205:Ascorbic Acid; D003683:Dehydroascorbic Acid