title: Specific immunoglobulin M and G antibodies in the rapid diagnosis of human treponemal infections.
abstract: The serological response to treponemal infections in men before and after specific treatment is analyzed. From the described observations several consequences and possibilities for a specific immunological diagnosis are discussed. In particular, it is shown that early diagnosis of syphilis in need of treatment can be achieved by demonstration of T pallidum-specific IgM antibodies. Finally, new insights into the role of antibody correlations between serum and cerebrospinal fluid are mentioned that have established the detection of asymptomatic neurosyphilis.
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis* / Q000096:biosynthesis; D000918:Antibody Specificity; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000032:analysis / Q000096:biosynthesis; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009494:Neurosyphilis / Q000175:diagnosis / Q000276:immunology; D010406:Penicillins / Q000627:therapeutic use; D013587:Syphilis / Q000188:drug therapy / Q000276:immunology; D013588:Syphilis Serodiagnosis / Q000379:methods*; D013590:Syphilis, Congenital / Q000175:diagnosis; D014210:Treponema pallidum / Q000276:immunology; D014211:Treponemal Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010406:Penicillins