[Stability and absorption of liposomes with incorporated insulin in the small intestine].
Lecithin-cholesterol liposomes with the incorporated insulin were studied in vitro for their stability to the action of some factors of gastrointestinal tract--hydrochloric acid, gastric juice, pepsin, trypsin, bile. A considerable destructive action of bile on liposomes is established. Modification of the lipid composition of liposomes makes it possible to increase their stability to the bile action. Suction of liposomes from the isolated sites of rat small intestine is studied. Insulin from liposomes is established to be sucked most intensive from the initial parts of small intestine. In this case it penetrates into the blood bed not in a free state but in the composition of liposomes.
D000818:Animals; D001646:Bile / Q000378:metabolism; D004355:Drug Stability; D066298:In Vitro Techniques; D007328:Insulin / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D008081:Liposomes; D010447:Peptide Hydrolases
Stabil'nost' i vsasyvanie liposom s vkliuchennym insulinom v tonkom kishechnike.