[Elimination of Klebsiella pneumoniae and humoral immunity in immunization with the IS-4 immunostimulating mixture].
The present investigation has revealed that in mice, immunized with preparation HC-4 (an immunostimulating agent consisting of water-soluble antigenic complexes obtained from 4 opportunistic microorganisms: Klebsiella pneumoniae, staphylococcus, Proteus and Escherichia coli K-100 having a common antigen with Haemophilus influenzae) and challenged with K. pneumoniae culture on day 7 after immunization, the complete elimination of K. pneumoniae from the blood occurs within 24 hours. The subcutaneous immunization of rabbits with the above preparation leads to a significant increase in antibody titers, determined in the passive hemagglutination test with Klebsiella diagnosticum. The test of the passive protection of mice from Klebsiella sepsis has revealed a rise in the preventive activity of the sera of rabbits immunized with this preparation.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000276:immunology*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000276:immunology; D006386:Hemagglutination Tests; D007116:Immunization, Passive / Q000379:methods*; D007710:Klebsiella Infections / Q000517:prevention & control; D007711:Klebsiella pneumoniae / Q000276:immunology*; D051379:Mice; D011511:Proteus / Q000276:immunology; D011817:Rabbits; D012995:Solubility; D013210:Staphylococcus / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D004338:Drug Combinations
Eliminatsiia klebsielly pnevmonii i gumoral'nyĭ immunitet pri immunizatsii immunostimuliruiushcheĭ smesi IS-4.