An experimental model for the detection and localisation of gastrointestinal bleeding using 99mTc-DTPA.
99mTc-DTPA was successfully used to detect simultaneously gastrointestinal bleeding sites in experimentally created mucosal ulcers in the colon and stomach of rabbits. Unlike the other radiopharmaceuticals that are currently used, 99mTc-DTPA was rapidly cleared from the vascular, hepatic and splenic circulation. The overall background radioactivity was low. 99mTc-DTPA appears to be an ideal agent for detection and localisation of gastrointestinal bleeding sites.
D000818:Animals; D003108:Colonic Diseases / Q000000981:diagnostic imaging; D006471:Gastrointestinal Hemorrhage / Q000000981:diagnostic imaging*; D004369:Pentetic Acid; D010438:Peptic Ulcer Hemorrhage / Q000000981:diagnostic imaging; D011817:Rabbits; D011877:Radionuclide Imaging; D013276:Stomach Ulcer / Q000000981:diagnostic imaging; D013667:Technetium; D016284:Technetium Tc 99m Pentetate
D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate