Absorption of anticancer drugs through bladder epithelium.
Fundamental and clinical evaluations of ten anticancer drugs were performed. The required qualities of an anticancer drug ideal for bladder instillation therapy are thought to be as follows: (1) a high sensitivity for bladder tumor cells; (2) a pKa which provides a high percentage of nonionized molecules in a pH 6-7 solution; (3) a log P in the range from -0.4 to -1.2 or from -7.5 to -8.0; and (4) a molecular weight over 200.
D000042:Absorption; D000632:Aminopyrine / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D004396:Coloring Agents / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D007474:Ion Exchange; D008970:Molecular Weight; D012995:Solubility; D013419:Sulfamethizole / Q000378:metabolism; D001743:Urinary Bladder / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000378:metabolism
D000970:Antineoplastic Agents; D004396:Coloring Agents; D000632:Aminopyrine; D013419:Sulfamethizole