title: The value of flunarizine in the treatment of tinnitus.
abstract: The suppressive effect of flunarizine on tinnitus was assessed in a double-blind trial in 50 patients with tinnitus due to various causes. The duration of the study was 6 weeks. Serum levels of the drug were determined. The patient's subjective assessment of the effect was taken as criterion for the evaluation; objective tests were found to be unsuitable for this purpose. Ten of the patients suffered from dizziness as a secondary complaint. For the group as a whole, there was no difference between flunarizine and the placebo with respect to the effect on tinnitus, but in the 10 patients with dizziness as well there was a significant difference in favor of the drug. Conclusions cannot be drawn as to the reason for this divergence, because the number of patients was too small.
mesh_terms: D000328:Adult; D000368:Aged; D002936:Cinnarizine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005444:Flunarizine; D006801:Humans; D008297:Male; D008875:Middle Aged; D014012:Tinnitus / Q000097:blood / Q000188:drug therapy* / Q000209:etiology
chemical_list: D002936:Cinnarizine; D005444:Flunarizine