Acute, severe, central and peripheral nervous system combined demyelination.
Acute disseminated encephalomyelopathy and Guillain-Barré syndrome are both immunologically mediated para-infectious demyelinating disorders, the former affecting the central nervous system and the latter affecting the peripheral nervous system. The term encephalo-myelo-radiculo-neuropathy was introduced to describe cases in which major involvement of one system, most commonly the peripheral, was associated with mild involvement of the other. We present a case of acute severe demyelination simultaneously affecting both the central and the peripheral nervous systems in a 10-year-old female. This clinical picture combines acute disseminated encephalomyelopathy and Guillain-Barré syndrome, both of which are extremely severe.
D000208:Acute Disease; D002648:Child; D003711:Demyelinating Diseases / Q000175:diagnosis*; D004679:Encephalomyelitis / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009460:Neurologic Examination; D011129:Polyradiculoneuropathy / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed