Enhanced percutaneous absorption of homogenized tolnaftate/beta-cyclodextrin polymer ground mixture.
The absorption of tolnaftate after external application of tolnaftate-cyclodextrin polymer homogenized ground mixtures was investigated in comparison with that of tolnaftate alone and non-homogenized mixtures. To evaluate their percutaneous absorption, samples were applied to the shaved back skin of mice. It was found that homogenized ground mixture samples showed the highest level of percutaneous absorption, and also resulted in the highest blood level concentrations.
D000818:Animals; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011108:Polymers; D012869:Skin Absorption; D012995:Solubility; D014047:Tolnaftate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D011108:Polymers; D047392:beta-Cyclodextrins; D014047:Tolnaftate; C031215:betadex