The effect of oral potassium chloride on upper gastrointestinal mucosa in healthy subjects: healing of lesions despite continuing treatment.
The effects of two dosage forms of wax-polymer matrix potassium chloride on the upper gastrointestinal mucosa were compared with placebo in 44 healthy volunteers. After 2 weeks of potassium chloride treatment, mucosal toxicity was observed. There was no correlation between the presence of lesions and symptoms. Six of seven volunteers with lesions healed spontaneously despite continuing treatment with potassium chloride.
D000284:Administration, Oral; D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D007410:Intestinal Diseases / Q000139:chemically induced / Q000628:therapy*; D007413:Intestinal Mucosa / Q000187:drug effects*; D008297:Male; D014677:Pharmaceutical Vehicles; D010919:Placebos; D011108:Polymers; D011189:Potassium Chloride / Q000008:administration & dosage / Q000009:adverse effects*; D013272:Stomach Diseases / Q000139:chemically induced / Q000628:therapy*; D014885:Waxes
D014677:Pharmaceutical Vehicles; D010919:Placebos; D011108:Polymers; D014885:Waxes; D011189:Potassium Chloride