[Thermoinduced radioresistance of Escherichia coli cells and heat shock proteins].
Radioresistance of E. coli cells is slightly increased (dose modification factor (DMF) = 1.2) with temperature elevated from 4 degrees to 43 degrees C at the time of gamma-irradiation. However, an appreciable effect of the thermoinduced radioresistance (DMF = 1.7) was observed when the wild-type cells were exposed to gamma-radiation at 15-43 degrees C (but not at 4 degrees C) after 30-min preincubation at 43 degrees C. This effect was absent in htpR mutants, defective in induction of heat shock proteins, and coupled with the decreased post-irradiation DNA degradation in gamma-irradiated htpR+ cells. It is suggested that heat shock proteins are involved in the thermoinduced radioresistance.
D004269:DNA, Bacterial / Q000378:metabolism / Q000528:radiation effects; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism / Q000528:radiation effects*; D006360:Heat-Shock Proteins / Q000096:biosynthesis* / Q000528:radiation effects; D006358:Hot Temperature; D009154:Mutation; D011836:Radiation Tolerance
D004269:DNA, Bacterial; D006360:Heat-Shock Proteins
Termoindutsirovannaia radiorezistentnost' kletok Escherichia coli i belki teplovogo toka.