Increased Con-A-induced thymocyte proliferation and de novo Qa-2 antigen expression in Qa-2-depleted thymocyte cultures.
We have recently shown that thymocyte activation is associated with a strong increase of Qa-2 antigen expression. Contrary to what could be predicted from these results, the initial depletion of Qa-2+ cells from PNA- thymocytes increases the Con-A-induced proliferation. Qa-2+ cells not only reappeared after activation, but were enhanced in Qa-2-depleted PNA- cells compared to the control. The newly formed Qa-2+ population contained a higher percentage of Lyt 1+2- cells and thus seems to be different from the Qa-2+ pool initially present.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects; D000950:Antigens, Ly / Q000032:analysis / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology* / Q000302:isolation & purification; D002478:Cells, Cultured; D003208:Concanavalin A / Q000276:immunology / Q000494:pharmacology*; D005260:Female; D005455:Fluorescent Antibody Technique; D015395:Histocompatibility Antigens Class I; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008212:Lymphocyte Depletion; D051379:Mice; D008815:Mice, Inbred Strains; D019887:Peanut Agglutinin; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000276:immunology
D000950:Antigens, Ly; D000954:Antigens, Surface; D015395:Histocompatibility Antigens Class I; D037102:Lectins; D019887:Peanut Agglutinin; C032907:Q surface antigens; D003208:Concanavalin A