Nucleologram variations in circulating lymphocytes after chemotherapy.
The lymphocyte nucleologram of cancer patients was studied before and after chemotherapy. Drug treatment was constantly followed by morphological and numerical changes in lymphocyte nucleolar pattern, characterized by an increase in micropolynucleolated forms. This variation is a non-specific marker of drug cytotoxicity.
D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002466:Cell Nucleolus / Q000473:pathology*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy / Q000473:pathology
D000970:Antineoplastic Agents