title: Increased thromboxane level in experimental spinal cord injury.
abstract: An increased accumulation of tissue thromboxane A2 occurred shortly after spinal cord injury. Prostacyclin formation was not affected. The magnitude of the increase in thromboxane and the extent of post-traumatic vascular damage as determined by extravasation of 125I-labeled human serum albumin were both dependent on the degree of injury. These findings raise the possibility that activation of arachidonic acid metabolism with a preponderance in thromboxane formation may contribute to microvascular injury in experimental spinal cord contusion.
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis*; D000818:Animals; D001808:Blood Vessels / Q000473:pathology; D004487:Edema / Q000473:pathology; D011464:Epoprostenol / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000032:analysis* / Q000098:blood supply; D013119:Spinal Cord Injuries / Q000378:metabolism* / Q000473:pathology; D013928:Thromboxane A2 / Q000096:biosynthesis; D013929:Thromboxane B2 / Q000032:analysis*
chemical_list: D013929:Thromboxane B2; D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol