title: Epidemiological evaluation of radiation risk using populations exposed at high doses.
abstract: Reasons are discussed for basing cancer risk estimates of low-dose radiation effects on extrapolations from populations exposed to high doses, rather than directly on studies of low-dose effects. Some of the major studies used for this purpose are described, together with difficulties encountered in extrapolating from them. Some recent statistical work to aid the evaluation of radiation risk from these studies is reviewed.
mesh_terms: D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007953:Leukemia, Radiation-Induced; D008297:Male; D009101:Multiple Myeloma / Q000209:etiology / Q000401:mortality; D009381:Neoplasms, Radiation-Induced; D009689:Nuclear Warfare; D011834:Radiation Monitoring; D012306:Risk; D012907:Smoking; D013167:Spondylitis, Ankylosing / Q000209:etiology