Effect of four serum components on survival of Treponema pallidum and its attachment to rabbit cells in vitro.
Transferrin and, to a lesser extent, insulin were two components of serum that enhanced the survival of Treponema pallidum in microaerophilic, acellular medium. These two components also enhanced the attachment of T pallidum to baby rabbit genital organ (BRGO) cells in both aerobic and microaerophilic tissue culture systems. Growth hormone and epidermal growth factor marginally enhanced the attachment of T pallidum to BRGO cells.
D000818:Animals; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005835:Genitalia / Q000166:cytology; D013006:Growth Hormone / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D014168:Transferrin / Q000494:pharmacology*; D014210:Treponema pallidum / Q000187:drug effects* / Q000502:physiology
D007328:Insulin; D014168:Transferrin; D004815:Epidermal Growth Factor; D013006:Growth Hormone