Intersubject variability in corneal swelling response to anoxia.
A controlled, double-masked, randomized experiment was conducted on 9 human subjects, to determine whether there is an intersubject difference in the corneal swelling response to anoxia. A statistically significant intersubject variability was observed (P less than 0.001), with oedema ranging from a mean of 3.6% to 7.3% following 3 h exposure to humidified nitrogen gas (anoxia). This result supports the hypothesis of previous workers that the intersubject difference in the corneal oedema response to a thick HEMA "stress lens" is due to oxygen deprivation and not some other physiological variable resulting from lens wear.
D000328:Adult; D002986:Clinical Trials as Topic; D003261:Contact Lenses / Q000009:adverse effects; D003316:Corneal Diseases / Q000209:etiology*; D004311:Double-Blind Method; D004487:Edema / Q000209:etiology*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D009584:Nitrogen; D011897:Random Allocation; D013045:Species Specificity
D009584:Nitrogen