title: The effect of lignocaine on nasal resistance and nasal sensation of airflow.
abstract: The effect of lignocaine on nasal sensation of airflow and nasal resistance was assessed in twenty-five subjects. A randomised crossover trial was conducted with lignocaine as the active drug and saline as the placebo. Both substances were delivered to the nasal mucosa as a nasal spray. Lignocaine caused a sensation of increased nasal patency in twenty-two of the twenty-five subjects studied. Saline had no such effect. The difference between this subjective effect of the two substances was highly significant (p less than 0.001). Neither spray had any significant effect on nasal resistance to airflow assessed objectively by rhinomanometry.
mesh_terms: D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008365:Manometry; D009666:Nose / Q000187:drug effects / Q000502:physiology*; D012123:Pulmonary Ventilation; D011897:Random Allocation; D012677:Sensation; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D012965:Sodium Chloride; D008012:Lidocaine