[Determination of serum proline iminopeptidase activity using a fluorescent substrate in patients with Paget's disease and prostatic bone metastases. Preliminary results].
Assessment of proline iminopeptidase activity in serum has been performed in 80 control subjects, 14 Paget's diseases and 10 patients with prostatic and osteoblastic bone metastases. In normal subjects, the PIP activity rises with age, mainly (+63%) in women after menopause. In benign or malignant osteoblastic bone diseases PIP activity is elevated and slightly related to urinary hydroxyproline excretion (r = 0.76) which evolution is close to. It is concluded that PIP activity dosage in serum may provide with urinary hydroxyproline, further information for the study of collagen metabolism in osteoblastic bone diseases during treatment.
D000328:Adult; D000626:Aminopeptidases / Q000097:blood*; D001859:Bone Neoplasms / Q000201:enzymology / Q000556:secondary*; D003374:Coumarins; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides; D010001:Osteitis Deformans / Q000201:enzymology*; D011471:Prostatic Neoplasms / Q000201:enzymology*
D003374:Coumarins; D009842:Oligopeptides; C023859:succinylglycyl-prolyl-leucyl-glycyl-prolyl-4-methylcoumaryl-7-amide; D000626:Aminopeptidases; C022450:prolyl aminopeptidase; D006909:Hydroxyproline
Détermination de l'activité proline imino-peptidase dans le sérum à l'aide d'un substrat fluorescent dans la maladie de Paget et les métastases osseuses condensantes prostatiques. Résultats préliminaires.