Focal axonal swellings in rat cerebellar Purkinje cells during normal development.
Focal axonal swellings are characteristic of a wide range of neuropathies. Three neuron-specific monoclonal antibodies have been used to identify focal axonal swellings in the normal developing rat cerebellar cortex. Between 7 and 15 days postnatal, swellings are a common feature of the granular layer and white matter tracts. Using a Purkinje cell-specific antibody, the majority of swellings were shown to occur in Purkinje cell axons. Focal axonal swellings therefore seem to be a normal adjunct of Purkinje cell maturation.
D000818:Animals; D000831:Animals, Newborn; D000911:Antibodies, Monoclonal; D001369:Axons / Q000648:ultrastructure*; D002525:Cerebellar Cortex / Q000254:growth & development*; D007124:Immunoenzyme Techniques; D011689:Purkinje Cells / Q000166:cytology* / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains
D000911:Antibodies, Monoclonal