A Candida albicans rough-type mutant with increased cell surface hydrophobicity and a structural defect in the cell wall mannan.
A Candida albicans rough-type mutant showing increased hydrophobicity of the cell surface was isolated. The mutant cells contained about one-quarter as much mannan as the wild type, and were defective in antigenic factors 1, 4, 5, and 6. Acetolysis fingerprinting demonstrated that the mutant mannan had a structural defect in its carbohydrate skeleton.
D000946:Antigens, Fungal / Q000032:analysis; D002176:Candida albicans / Q000032:analysis* / Q000235:genetics / Q000254:growth & development / Q000276:immunology; D002473:Cell Wall / Q000032:analysis; D003470:Culture Media; D008351:Mannans / Q000032:analysis*; D009154:Mutation
D000946:Antigens, Fungal; D003470:Culture Media; D008351:Mannans