Corticotropin-releasing factor (CRF) inhibits gonadotropin-releasing hormone (GnRH) release from superfused rat hypothalami in vitro.
A dose-dependent suppression of basal gonadotropin-releasing hormone (GnRH) release was observed when rat hypothalamic slices were superfused with human/rat corticotropin-releasing factor (CRF) (10(-12) to 10(-8) M). CRF was also found to significantly reduce the amount of GnRH released in response to 56 mM KCl. These in vitro results demonstrate that the CRF inhibition of GnRH secretion observed in vivo occurs within the hypothalamus and independently of the CRF activation of the pituitary-adrenal-gonadal axis.
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D003864:Depression, Chemical; D007031:Hypothalamus / Q000378:metabolism*; D066298:In Vitro Techniques; D010906:Pituitary Hormone-Releasing Hormones / Q000378:metabolism*; D051381:Rats
D010906:Pituitary Hormone-Releasing Hormones; D003346:Corticotropin-Releasing Hormone