[UMP synthase activity of rat tissue extracts in the bone marrow form of radiation sickness].
Whole-body gamma-irradiation of rats with a dose inducing bone marrow radiation syndrome caused phase organospecific changes in UMP-synthase activity. Disturbances of enzymic activity in the bone marrow and spleen well correlated with the dynamics of interphase and reproductive cell death. In brain extracts, UMP biosynthesis from orotic acid did not undergo essential changes.
D000818:Animals; D001853:Bone Marrow / Q000201:enzymology / Q000528:radiation effects; D001921:Brain / Q000201:enzymology / Q000528:radiation effects; D002262:Carboxy-Lyases / Q000378:metabolism*; D002588:Cesium Radioisotopes; D005720:Gamma Rays; D008297:Male; D009097:Multienzyme Complexes / Q000378:metabolism*; D009962:Orotate Phosphoribosyltransferase / Q000378:metabolism*; D009964:Orotidine-5'-Phosphate Decarboxylase / Q000378:metabolism*; D010430:Pentosyltransferases / Q000378:metabolism*; D011833:Radiation Injuries, Experimental / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000201:enzymology / Q000528:radiation effects; D014916:Whole-Body Irradiation
D002588:Cesium Radioisotopes; D009097:Multienzyme Complexes; C027157:uridine 5'-monophosphate synthase; D010430:Pentosyltransferases; D009962:Orotate Phosphoribosyltransferase; D002262:Carboxy-Lyases; D009964:Orotidine-5'-Phosphate Decarboxylase
Aktivnost' UMF-sintazy v ékstraktakh tkaneĭ krys pri kostnomozgovoĭ forme luchevoĭ bolezni.