title: Nuclear medicine and the environment: radiation interactions.
abstract: The effect of radiation interactions on the environment may be considered from the perspective of the purely physical phenomena occurring or from the effects the interactions produce in organized biological systems. The physical processes by which radiation interacts with the environment are quite well defined. Although these processes differ depending upon the nature (either electromagnetic or particulate) of the primary radiation, the ultimate result is the production in the medium of high-speed, secondary charged particles. Some of the energy of these particles is absorbed by the medium, while a portion may be lost as bremsstrahlung. The energy that is absorbed produces excitation and ionization, which can be disruptive to biological systems. The effects produced by ionizing radiations at the biochemical, cellular, and organ level are less well defined. Nevertheless, available data indicate that certain generalizations are possible. For example, given the ubiquitous nature of water in tissues, macromolecules, regardless of their structural types, tend to serve as acceptors of the energy and products of water radiolysis. However, a deeper insight into the consequences of irradiation requires an understanding of the interplay of such parameters as the type and energy of the radiation, and the dose and rate of its application. Furthermore, at the cellular level, the type and age of the irradiated cells, the concentration of oxygen in their environment, and their cell-cycle phase are all important factors in determining the consequences of irradiation.
mesh_terms: D000596:Amino Acids / Q000528:radiation effects; D000818:Animals; D002477:Cells / Q000528:radiation effects; D004247:DNA / Q000528:radiation effects; D004735:Energy Transfer; D004782:Environmental Health; D006801:Humans; D009154:Mutation / Q000528:radiation effects; D011506:Proteins / Q000528:radiation effects; D011827:Radiation; D011830:Radiation Effects; D011853:Radiobiology; D011854:Radiochemistry
chemical_list: D000596:Amino Acids; D011506:Proteins; D004247:DNA