Effect of bombesin and gastrin-releasing peptide on the release of gastric inhibitory polypeptide and insulin in rats.
The objective of this study was to determine whether bombesin- or gastrin-releasing peptide-induced release of insulin occurs before or after the release of gastric inhibitory polypeptide (GIP) in rats. The present results demonstrate that GIP release occurs before insulin release and suggest that bombesin-like peptides and GIP interact to stimulate insulin secretion.
D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D005749:Gastric Inhibitory Polypeptide / Q000097:blood / Q000378:metabolism*; D019886:Gastrin-Releasing Peptide; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D007328:Insulin; D010455:Peptides; D005749:Gastric Inhibitory Polypeptide; D019886:Gastrin-Releasing Peptide; D001839:Bombesin