[Experimental substantiation of the treatment of patients with rheumatoid arthritis with prednisolone and its combination with retabolil (clinico-experimental study)].
Fifty RA patients receiving prednisolone and prednisolone combined with retabolil were examined. Prednisolone made a negative effect on central hemodynamics, the effect being less with the use of retabolil. A dystrophic action of prednisolone on the myocardium and the weakening of this effect in a combined use of prednisolone and retabolil were shown on a RA model in rabbits.
D000328:Adult; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077603:Nandrolone Decanoate; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits
D009277:Nandrolone; D011239:Prednisolone; D000077603:Nandrolone Decanoate
Eksperimental'noe obosnovanie lecheniia bol'nykh revmatoidnym artritom prednizolonom i sochetaniem ego s retabolilom (kliniko-eksperimental'noe issledovanie).