[Cyclosporin A and hyperlipidemia after kidney transplantation. Prospective study].
Hyperlipidemia is common after renal transplantation and has been attributed, at least in part, to corticosteroid therapy. We therefore studied serum lipids in a group of nondiabetic transplant recipients on conventional immunosuppression with azathioprin and prednisone (Aza/P), in comparison with a transplanted group on cyclosporin A monotherapy (CyA) without steroids. Frequency and degree of hyperlipidemia in the two groups showed no significant difference. Atherogenic hypercholesteremia was found as frequently in patients on CyA as in those on Aza/P. Possible factors preventing normalization are discussed.
D000328:Adult; D001379:Azathioprine / Q000009:adverse effects; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000139:chemically induced; D006949:Hyperlipidemias / Q000139:chemically induced*; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D011241:Prednisone / Q000009:adverse effects; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood
D003524:Cyclosporins; D014280:Triglycerides; D001379:Azathioprine; D011241:Prednisone
Cyclosporin A und Hyperlipidämie nach Nierentransplantation. Eine prospektive Untersuchung.