Brain spectrin(240/235) and brain spectrin(240/235E): two distinct spectrin subtypes with different locations within mammalian neural cells.
Adult mouse brain contains at least two distinct spectrin subtypes, both consisting of 240-kD and 235-kD subunits. Brain spectrin(240/235) is found in neuronal axons, but not dendrites, when immunohistochemistry is performed with antibody raised against brain spectrin isolated from enriched synaptic/axonal membranes. A second spectrin subtype, brain spectrin(240/235E), is exclusively recognized by red blood cell spectrin antibody. Brain spectrin(240/235E) is confined to neuronal cell bodies and dendrites, and some glial cells, but is not present in axons or presynaptic terminals.
D000818:Animals; D001369:Axons / Q000032:analysis; D001923:Brain Chemistry; D003712:Dendrites / Q000032:analysis; D007106:Immune Sera / Q000032:analysis; D007124:Immunoenzyme Techniques; D051379:Mice; D009474:Neurons / Q000032:analysis*; D009928:Organ Specificity; D013049:Spectrin / Q000276:immunology / Q000302:isolation & purification*; D013570:Synaptic Membranes / Q000032:analysis
D007106:Immune Sera; D013049:Spectrin