title: Adenosine deaminase and histidine decarboxylase coexist in certain neurons of the rat brain.
abstract: The enzymes adenosine deaminase (ADA) and histidine decarboxylase (HDC) were immunocytochemically detected in rat brain. The gross distributions of ADA- and HDC-immunoreactive neurons in the basal hypothalamus were very similar. The superficial layers of the superior colliculus showed only ADA-containing neurons. Using adjacent thin-sections of basal hypothalamus, stained alternately for ADA and HDC immunoreactivity, it was possible to show the two labels localized within the same neurons. These observations imply a relationship between two neurochemically distinct putative neurotransmitter/modulator systems, that of histamine and adenosine.
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002262:Carboxy-Lyases / Q000378:metabolism*; D006640:Histidine Decarboxylase / Q000378:metabolism*; D007031:Hypothalamus / Q000201:enzymology; D007124:Immunoenzyme Techniques; D008297:Male; D009700:Nucleoside Deaminases / Q000378:metabolism*; D051381:Rats; D012688:Septum Pellucidum / Q000201:enzymology; D013477:Superior Colliculi / Q000201:enzymology
chemical_list: D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase; D002262:Carboxy-Lyases; D006640:Histidine Decarboxylase