Endogenous opioids and post-ictal increase in seizure threshold in Mongolian gerbils.
In gerbils, the convulsive thresholds both for electroconvulsions and for pentetrazole-induced convulsions were increased when determined 15 min after a convulsion elicited by an air blast to the back of the animals. Contrary to a recently offered hypothesis, this sign of post-ictal depression could not be reversed by pretreatment with the morphine antagonists naloxone and naltrexone. This result speaks against a mediation of post-ictal depression by endogenous opioids.
D000818:Animals; D004558:Electric Stimulation; D004723:Endorphins / Q000378:metabolism / Q000502:physiology*; D005849:Gerbillinae / Q000378:metabolism* / Q000502:physiology; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000494:pharmacology; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology
D004723:Endorphins; D009270:Naloxone; D009271:Naltrexone; D009020:Morphine; D010433:Pentylenetetrazole