Atypical Histoplasma capsulatum infection in a dog.
Disseminated histoplasmosis was diagnosed in a 10-year-old dog suspected of having hepatic carcinoma. Clinical abnormalities included diffuse hepatomegaly, gastrointestinal bleeding, thoracic and abdominal effusion, anemia, leukocytosis, and thrombocytopenia. Histoplasmosis characteristically is a disease of the mononuclear phagocyte system, but in this case was diagnosed by finding Histoplasma capsulatum organisms in neutrophils on the blood smear.
D000309:Adrenal Insufficiency / Q000175:diagnosis / Q000662:veterinary; D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy; D004285:Dogs; D005260:Female; D005455:Fluorescent Antibody Technique; D006658:Histoplasma / Q000648:ultrastructure; D006660:Histoplasmosis / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D009504:Neutrophils / Q000382:microbiology
D000666:Amphotericin B