title: Imidazo[2,1-b]benzothiazoles. 2. New immunosuppressive agents.
abstract: A series of 2-phenylimidazo[2,1-b]benzothiazole derivatives was prepared and tested for immunological activities. Some of the compounds showed significant suppressive activity of delayed type hypersensitivity (DTH) without inhibition of humoral immunity in mice by oral administration. The most active compound was 2-(m-hydroxyphenyl)imidazo[2,1-b]benzothiazole (20).
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D052160:Benzothiazoles; D005260:Female; D006462:Hemolytic Plaque Technique; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000138:chemical synthesis*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D052160:Benzothiazoles; D007093:Imidazoles; D007166:Immunosuppressive Agents; D013844:Thiazoles; C005465:benzothiazole