A double-blind controlled study of chlormethiazole and triazolam as hypnotics in the elderly.
This study compared the hypnotic efficacy and the psychometric effects of treatment with either chlormethiazole or triazolam for 9 weeks in elderly patients with sleep disturbance. Chlormethiazole and triazolam were found to be similarly effective in short-term use. However, evidence of sustained hypnotic efficacy throughout the 9 weeks of treatment was obtained for chlormethiazole but not for triazolam. There were daytime withdrawal effects with triazolam, but none with chlormethiazole.
D000368:Aged; D001143:Arousal / Q000187:drug effects; D002719:Chlormethiazole / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005425:Flicker Fusion / Q000187:drug effects; D006801:Humans; D008297:Male; D011897:Random Allocation; D011930:Reaction Time / Q000187:drug effects; D012684:Sensory Thresholds; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D012894:Sleep Stages / Q000187:drug effects; D014229:Triazolam / Q000009:adverse effects / Q000627:therapeutic use*
D002719:Chlormethiazole; D014229:Triazolam