title: Synergistic effects of weak-acid preservatives and pH on the growth of Zygosaccharomyces bailii.
abstract: In completely randomised factorial experiments, individual and synergistic effects of pH, benzoic acid and sorbic acid on the growth rate of the yeast Zygosaccharomyces bailii were determined, and expressed in polynomial equations. Synergism between benzoic and sorbic acid was pH dependent. A distinct effect of the anionic form of benzoic acid on doubling time was demonstrated by experiments in which concentrations of benzoic acid and benzoate were varied. The resultant polynomial equation showed that both species act synergistically.
mesh_terms: D001565:Benzoates / Q000494:pharmacology*; D019817:Benzoic Acid; D002455:Cell Division / Q000187:drug effects; D003627:Data Interpretation, Statistical; D004357:Drug Synergism; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005520:Food Preservatives / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D004718:Saccharomycetales / Q000166:cytology* / Q000187:drug effects*; D013011:Sorbic Acid / Q000494:pharmacology*
chemical_list: D001565:Benzoates; D005231:Fatty Acids, Unsaturated; D005520:Food Preservatives; D019817:Benzoic Acid; D013011:Sorbic Acid