title: A randomized double-blind placebo-controlled study of dipyrone and aspirin in post-operative orthopaedic patients.
abstract: Two hundred and fifty-four patients with post-operative pain following closed reduction of fractured long bones completed a double-blind study of dipyrone and aspirin. Compared with placebo both active treatments produced significant relief of pain, which was apparent 30 minutes after ingestion and was maintained for the 6-hour duration of the study. Dipyrone 500 mg produced significantly greater pain relief than aspirin 500 mg. Both drugs were generally well tolerated.
mesh_terms: D000328:Adult; D000632:Aminopyrine / Q000031:analogs & derivatives*; D001241:Aspirin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004177:Dipyrone / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D050723:Fractures, Bone / Q000601:surgery; D006801:Humans; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy*; D010919:Placebos; D011897:Random Allocation; D013997:Time Factors
chemical_list: D010919:Placebos; D000632:Aminopyrine; D004177:Dipyrone; D001241:Aspirin