title: Cephalic phase insulin secretion in relation to food presentation in normal and overweight subjects.
abstract: The existence of a preabsorptive insulin reflex is well known in animals but remains controversial in humans. Glycemia and insulin variations following olfactive and visual presentation of a standard meal were studied in 25 subjects, 10 of them (5 men and 5 women) of normal weight and 15 overweight (7 men and 8 women), after a 15 hour fast. Blood samples were collected continuously, every minute for 16 minutes after the meal was presented. The presentation produced an early blood insulin increment, variable in magnitude and time course and occurring between the 3rd and 9th minute, in both normal and overweight subjects. Glycemia variations were not significant. Our study demonstrated a positive correlation between the reflex insulin release, body weight and a conscious effort to maintain current body weight. However, the differences between overweight and normal subjects remained small. The physiological and psychological determinants of the cephalic phase of insulin secretion are discussed.
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D005215:Fasting; D005260:Female; D005502:Food; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007700:Kinetics; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin