title: Dulcin: a centennial perspective.
abstract: The discovery of dulcin, the second synthetic sweetener, has been traced to the work of J. Berlinerblau. Early studies of this sweetener revealed a very effective sweetener that showed toxicity at high doses. Dulcin never achieved great recognition nor usage but was utilized slightly until a long-term study clearly pointed out its toxicity under sustained use with small doses.
mesh_terms: D000818:Animals; D049672:History, 19th Century; D010671:Phenylurea Compounds / Q000266:history* / Q000633:toxicity; D011044:Poland; D013549:Sweetening Agents / Q000266:history*
chemical_list: D010671:Phenylurea Compounds; D013549:Sweetening Agents; C004352:dulcin