The influence of lipoproteins (LDL and HDL) on PGI2-formation by isolated aortic preparations of rabbits.
The influence of LDL- and HDL-concentrations of 0.5-2.0 mg/ml and 0.25-1.0 mg/ml respectively, from male and female donors on the formation of PGI2 in isolated aortic preparations was investigated under in vitro conditions. LDL of male donors inhibited endogenous PGI2-formation and the conversion of exogenous PBH2 to PGI2. On the other hand the highest concentration of HDL induced an increase in the basal and in the stimulated PGI2-formation. Lipoproteins of female donors showed no or only a weak stimulating effect on PGI2-formation. Human serum albumin in comparable concentrations of 1-50 mg/ml remained without influence. The importance of the results for cardiovascular diseases is discussed.
D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects / Q000378:metabolism*; D011464:Epoprostenol / Q000378:metabolism*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D008297:Male; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology; D044262:Prostaglandin H2; D011463:Prostaglandins H / Q000494:pharmacology; D011817:Rabbits; D012709:Serum Albumin / Q000494:pharmacology; D012737:Sex Factors
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D011450:Prostaglandin Endoperoxides, Synthetic; D011463:Prostaglandins H; D012709:Serum Albumin; D044262:Prostaglandin H2; D011464:Epoprostenol