title: Effect of chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on sister chromatid exchange levels in peripheral lymphocytes of the rhesus monkey.
abstract: Frequencies of sister chromatid exchanges and chromosomal aberrations were examined in peripheral lymphocytes of Rhesus monkeys which had been fed a diet containing 25 parts per trillion 2,3,7,8-tetrachlorodibenzo-p-dioxin for a period of 4 years. When compared to non-exposed control animals, no significant differences were noted for either of these cytogenetic endpoints. In addition, there was not a significant difference in sister chromatid exchange response to a challenge dose of mitomycin C in cells from 2,3,7,8-tetrachlorodibenzo-p-dioxin exposed animals compared to controls. Our results confirm the lack of genotoxic effects associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure.
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations / Q000187:drug effects; D004147:Dioxins / Q000633:toxicity*; D005260:Female; D008214:Lymphocytes / Q000187:drug effects*; D008253:Macaca mulatta; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
chemical_list: D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins