Evaluation of mumps antibodies after measles-mumps-rubella (MMR) vaccines.
Mumps antibody titers before and after administration of MMR trivalent combined vaccines from 3 different company were evaluated by mumps IgG Enzyme Linked Immunosorbent Assay (ELISA) and by neutralizing antibody test (NT). Seroconversion rates determined with the ELISA were around 90% in all 3 different vaccines. The seroconversion by NT test ranged from 63% to 77%. The mumps ELISA is more sensitive method of determination of antibodies against mumps virus than NT. Since ELISA is a much simpler and easier method of determining antibodies than NT, it will be a method of choice in many clinical laboratories.
D000914:Antibodies, Viral / Q000096:biosynthesis*; D002675:Child, Preschool; D004338:Drug Combinations / Q000008:administration & dosage / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007223:Infant; D007564:Japan; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology*; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine / Q000008:administration & dosage / Q000276:immunology*; D009109:Mumps virus / Q000276:immunology*; D009500:Neutralization Tests; D012411:Rubella Vaccine / Q000008:administration & dosage / Q000276:immunology*
D000914:Antibodies, Viral; D004338:Drug Combinations; D007074:Immunoglobulin G; D008458:Measles Vaccine; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine; D012411:Rubella Vaccine