title: Effect of a bacterial extract on cellular and humoral immune responses in humans.
abstract: A lyophilized extract from E. coli (OM-89) was studied for its immunomodulating properties and tolerance in humans. Its oral administration to healthy volunteers produced a selective increase in the active T-cell population without changes in other lymphocyte populations. A significant increase in the proliferative response to concanavalin A and phytohemagglutin was recorded, but not to pokeweed mitogen. No significant changes were observed in the serum levels of IgG, IgA and IgM. The clinical and biological tolerance of OM-89 was excellent, without any adverse side-effects or production of circulating immune complexes or of autoantibodies, while the in vitro investigation showed that it is not a mitogen. Thus in healthy subjects OM-89 seems to act mainly on the cell-mediated immune responses.
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects*; D000942:Antigens, Bacterial; D002478:Cells, Cultured; D004926:Escherichia coli / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007958:Leukocyte Count / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D012016:Reference Values
chemical_list: D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; C050501:OM 89