title: [Changes in the levels of soluble HLA antigens and their light chains (beta 2 microglobulin) in rheumatoid arthritis and systemic lupus erythematosus].
abstract: An increase in the level of soluble HLA-A and B antigens in the blood serum of patients with rheumatoid arthritis and systemic lupus erythematosus was observed using IKO-1 monoclonal antibodies and polyspecific alloantisera. This increase was accompanied by the elevation of the concentration of beta 2-microglobulin (the light chain of the molecules of HLA-antigens of the 1st class). A degree of the concentration of soluble HLA-antigens and beta 2-microglobulin depended on a degree of disease activity, a variant of a clinical course and the presence of visceral involvement.
mesh_terms: D000293:Adolescent; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012995:Solubility; D001613:beta 2-Microglobulin / Q000032:analysis*
chemical_list: D006680:HLA Antigens; D001613:beta 2-Microglobulin
vernacular_title: Izmeneniia urovnia rastvorimykh HLA-antigenov i ikh legkikh tsepeĭ (beta 2-mikroglobulina) pri revmatoidnom artrite i sistemnoĭ krasnoĭ volchanke.