title: Yeast RPO41 gene product is required for transcription and maintenance of the mitochondrial genome.
abstract: A 4-kilobase DNA fragment carried by a recombinant lambda gt11 bacteriophage appears to contain most of the coding information for the 145-kDa subunit of the Saccharomyces cerevisiae mitochondrial RNA polymerase. The RPO41 gene is located on chromosome VI, as determined by hybridization to electrophoretically separated yeast chromosomes. Hybridization and gene disruption/replacement experiments show that the RPO41 gene exists in a single copy and that its product is required for transcription and maintenance of the mitochondrial genome.
mesh_terms: D002467:Cell Nucleus / Q000502:physiology; D002874:Chromosome Mapping; D004261:DNA Replication; D004272:DNA, Mitochondrial / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000235:genetics*; D005796:Genes; D005800:Genes, Fungal; D008928:Mitochondria / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D004272:DNA, Mitochondrial; D012321:DNA-Directed RNA Polymerases