Mycotic vaginitis in pregnancy: a double evaluation of the susceptibility to the main antimycotic drugs of isolated species.
The authors examined 160 non-selected patients between the 28th and 40th weeks of gestational age with mycotic vaginitis. The chemosusceptibility of the isolated yeast to the main antimycotic drugs was evaluated through the Kirby-Bauer method as well as the determination of MIC. The antimycotic drugs tested were Nystatin, Miconazole, Ketoconazole, Clotrimazole, Amphotericin B, Econazole and 5-Fluorocytosine. The obtained data indicate a lacking effectiveness of Clotrimazole in contrast with the high percentage of therapeutical success reported in the literature. Better results were found with Econazole and the other antimycotic drugs tested. Nystatin is the most effective drug "in vitro". The authors furthermore highlight the utility of MIC determination, above all in the cases of recurrent vaginitis and when systemic therapy is undertaken.
D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third