title: [Ecological and toxicological control over the status of the environment by the methods of physicochemical biology].
abstract: Xenobiotic metabolism in the fish liver has been investigated with a view of developing test-system for biomonitoring based on multienzyme membrane-bound complexes. Extraction methods of xenobiotics from harmful pollutants and some biological tissue have been described using various sorbents and solvents. The own and literary data on the study of mutagenic effect of this contaminants and carcinogens in the Ames test-system in the presence of postmitochondrial fraction S9 from fish liver with 3-methylcholanthrene induced by microsomal oxidation system have been demonstrated.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004347:Drug Interactions; D004463:Ecology; D004784:Environmental Monitoring / Q000379:methods*; D004790:Enzyme Induction / Q000187:drug effects; D005399:Fishes / Q000378:metabolism; D007220:Industrial Waste / Q000009:adverse effects / Q000032:analysis; D008386:Marine Biology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009153:Mutagens / Q000032:analysis / Q000378:metabolism / Q000633:toxicity; D010105:Oxygenases / Q000096:biosynthesis; D012722:Sewage / Q000009:adverse effects / Q000032:analysis; D014586:USSR; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity; D014877:Water Pollution, Chemical / Q000032:analysis
chemical_list: D007220:Industrial Waste; D009153:Mutagens; D012722:Sewage; D014874:Water Pollutants, Chemical; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases
vernacular_title: Ekologo-toksikologicheskiĭ kontrol' za sostoianiem okruzhaiushcheĭ sredy metodami fiziko-khimicheskoĭ biologii.