[Antibodies against ds-DNA in systemic lupus erythematosus--value for diagnosis and determination of activity].
The specificities and sensitivities of 3 methods for detection of anti-ds-DNA-antibodies were investigated in 32 SLE-patients and 95 control patients with ANA greater than or equal to 1:100. The sensitivities of CL-IF-assay, filter-RIA and EIA were 47%, 78% and 87%, respectively. The according specificities were 96%, 88% and 84%. In contrast to the CL-IF-assay, the filter-RIA as well as the EIA are of major clinical importance in monitoring SLE-patients.
D000974:Antibodies, Antinuclear / Q000032:analysis*; D004247:DNA / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology*; D011863:Radioimmunoassay
D000974:Antibodies, Antinuclear; C026904:deoxyribonucleoprotein antibodies; D004247:DNA
Antikörper gegen ds-DNS bei systemischem Lupus erythematodes--Wertigkeit für Diagnose und Aktivitätsbestimmung.