Irrelevance of growth phase with respect to the Bay n 7133 and ICI 153,066 susceptibilities of Candida albicans.
Miconazole at 10(-5)-10(-4) M can kill Candida albicans in the logarithmic phase, but ketoconazole, the only established oral antifungal azole, cannot. Lethal potential in relation to growth phase was studied with Bay n 7133 and ICI 153,066, two recently developed oral triazoles. Each was strictly fungistatic regardless of phase of growth and was almost identical in effect to ketoconazole.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development*; D066298:In Vitro Techniques; D007654:Ketoconazole / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D014230:Triazoles / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D014230:Triazoles; C040032:ICI 153066; D008825:Miconazole; C037494:vibunazole; D007654:Ketoconazole