title: Sex differences in nerve growth factor levels in superior cervical ganglia and pineals.
abstract: The current studies were undertaken to determine whether males or neonatally testosterone-treated rats of either gender have elevated endogenous levels of NGF in the SCG and one of its targets, the pineal gland. The ages studied were 5 days postnatal, which is at the peak of normal neuron death in the SCG but before a significant gender difference is present; 15 days, when normal neuron death is largely complete and males have more SCG neurons than females; and 30 days, when target innervation has matured. At 5 days, while neuron death is occurring, but before there is a significant gender difference in neuron number in the SCG, pineal glands and SCGs of males had higher NGF content than those of females. The increased NGF in the ganglia of males at the time that these neurons are undergoing neuron death may play a role in the development of the sex difference in SCG neuron numbers. At 15 days, females had more NGF in their pineal glands and SCGs than did males, even though males have significantly more SCG neurons at this age than do females. This gender difference in the developmental course of NGF content could promote the survival of different populations of neurons in males and females. By 30 days, SCG and pineal NGF content of males was almost twice that of females. This is consistent with the presence of more neurons in the SCGs of males at this age. Both the pineal gland and the SCG showed a loss of approximately 80% content of NGF during the first postnatal month(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D005260:Female; D005727:Ganglia, Spinal / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D008297:Male; D009414:Nerve Growth Factors / Q000378:metabolism / Q000502:physiology*; D010870:Pineal Gland / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics; D013739:Testosterone / Q000494:pharmacology
chemical_list: D009414:Nerve Growth Factors; D013739:Testosterone