Isotype responses of mice to tetanus-toxoid preparations.
The development of anti-tetanus antibodies in CBA/Ca and Balb/c mice immunised with two tetanus-toxoid preparations has been investigated by sensitive enzyme-linked immunoassays. These studies revealed the presence in both strains of mice of naturally occurring antibodies to tetanus toxoid. These were of the IgM, IgA and, to a lesser extent, the IgG3 isotypes. Differences in the responses of mice to the two toxoid preparations were noted; the purer preparation elicited a more rapid and pronounced response. Both strains of mice exhibited similar isotype responses.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D003017:Clostridium tetani / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D013745:Tetanus Toxoid / Q000276:immunology*
D000907:Antibodies, Bacterial; D007132:Immunoglobulin Isotypes; D013745:Tetanus Toxoid