Antithrombotic effects of sodium salt of 17(R)-methyl-20-isopropylidenecarbacyclin in the arteriole of the hamster cheek pouch.
Antithrombotic effects of sodium salt of 17(R)-methyl-20-isopropylidenecarbacyclin (CS-570), a chemically stable prostaglandin I2 (PGI2, epoprostenol, prostacyclin) derivative, were investigated in the arteriole of the hamster cheek pouch. A microthrombus was produced by a slight mechanical injury followed by iontophoretic application of adenosine diphosphate (ADP) to an arteriole of 70 to 100 micron in diameter. The platelet thrombus size was determined with a video image processor. With this technique, a reproducible and quantitatively measurable periodical thrombus was obtained. CS-570 inhibited the thrombus formation dose-dependently. The potency of CS-570 was about 1/8 that of PGI2 and 6 times that of carbacyclin when infused i.v. CS-570 also decomposed an established thrombus. Alprostadil (PGE1), dipyridamole and ticlopidine failed to show inhibitory effects. The antithrombotic effect of CS-570 was definitely demonstrated.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000187:drug effects*; D002610:Cheek / Q000098:blood supply; D006224:Cricetinae; D004176:Dipyridamole / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology* / Q000031:analogs & derivatives; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D008297:Male; D008647:Mesocricetus; D012039:Regional Blood Flow / Q000187:drug effects; D013876:Thiophenes / Q000494:pharmacology; D013988:Ticlopidine; D013997:Time Factors
D005343:Fibrinolytic Agents; D013876:Thiophenes; D000244:Adenosine Diphosphate; D004176:Dipyridamole; C026678:carboprostacyclin; C038991:R 59274; D011464:Epoprostenol; D013988:Ticlopidine