title: [Effect of antioxidants on the synthesis of prostaglandins, prostacyclin and thromboxane in different layers of the kidneys of old rats].
abstract: The effects of L-tocopherol and synthetic antioxidants on synthesis of prostaglandins, thromboxane B2 and prostacyclin in different layers of the kidney against the background of chronic administration of polyene antibiotics (amphotericin B, levorin, nystatin) were studied in the experiments on aged rats. It was concluded that synthetic antioxidants regulate synthesis of these biologically active substances and also are able to protect the organ from the damaging effect of polyene antibiotics.
mesh_terms: D000375:Aging / Q000187:drug effects*; D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002174:Candicidin / Q000494:pharmacology; D004347:Drug Interactions; D011464:Epoprostenol / Q000032:analysis / Q000096:biosynthesis*; D007668:Kidney / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009761:Nystatin / Q000494:pharmacology; D011453:Prostaglandins / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D013931:Thromboxanes / Q000032:analysis / Q000096:biosynthesis*; D013997:Time Factors
chemical_list: D000975:Antioxidants; D011453:Prostaglandins; D013931:Thromboxanes; D009761:Nystatin; D002174:Candicidin; D000666:Amphotericin B; D011464:Epoprostenol
vernacular_title: Vliianie antioksidantov na sintez prostaglandinov, prostatsiklina i tromboksana v raznykh sloiakh pochek starykh krys.