Nephrotoxicity of cyclosporine in spontaneously hypertensive rats: effects on blood pressure and vascular lesions.
Cyclosporine (CSA) caused functional and morphologic renal changes in spontaneously hypertensive rats. The development of hypertensive arterial lesions were accelerated by CSA. Blood pressure was significantly increased especially in young rats. The influence of age of the animals, dose and duration of CSA administration on the development of vascular lesions and blood pressure was investigated.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000633:toxicity*; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000150:complications*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000150:complications; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D012083:Renin / Q000097:blood; D013997:Time Factors; D014508:Urea / Q000097:blood; D014652:Vascular Diseases / Q000150:complications*
D003524:Cyclosporins; D014508:Urea; D003404:Creatinine; D012083:Renin