The effect of platelet homogenate fractions on megakaryocytopoiesis in the mouse.
Platelet homogenate suppresses megakaryocytopoiesis more effectively than intact platelets do. In mouse experiments mitochondrial, lysosomal, and microsome fractions separated by ultracentrifugation from platelet homogenate did not influence megakaryocytopoiesis, while the cytosol fraction inhibited it similarly as platelet homogenate. Besides thrombopoietin, the substance released from the platelets also takes part in the regulation of thrombocytopoiesis and this substance passes into the cytosol fraction on separation by ultracentrifugation.
D000818:Animals; D001792:Blood Platelets / Q000502:physiology* / Q000528:radiation effects; D006410:Hematopoiesis / Q000528:radiation effects; D008297:Male; D008533:Megakaryocytes / Q000166:cytology*; D051379:Mice; D008815:Mice, Inbred Strains; D013347:Subcellular Fractions / Q000502:physiology; D014916:Whole-Body Irradiation