[Correction of proteolysis disturbances and erythrocyte resistance in experimental burns by the antioxidant carbaton].
The total proteolytic activity in blood and tissues and peroxide resistance of erythrocytes were studied in animals at different stages of burn disease. Carbaton, an antioxidant of a pyridine series, is analyzed for its effect on these indices. Considerable activation of proteolysis in tissues and a decrease of the erythrocyte resistance at burn shock and septicotoxemia stages are established. Carbaton being applied as a drug, influences positively the studied processes; a degree of the shift correction depends on the preparation dose.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D002056:Burns / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D010450:Endopeptidases / Q000097:blood* / Q000378:metabolism; D005609:Free Radicals; D006168:Guinea Pigs; D006461:Hemolysis / Q000187:drug effects*; D006868:Hydrolysis; D011725:Pyridines / Q000494:pharmacology* / Q000627:therapeutic use
D000975:Antioxidants; D005609:Free Radicals; D011725:Pyridines; C049414:carbaton; D010450:Endopeptidases
Korrektsiia narusheniĭ proteoliza i rezistentnosti éritrotsitov pri éksperimental'noĭ ozhogovoĭ bolezni antioksidantom karbatonom.