title: Cardiovascular effects of chronic naloxone infusion in normal dogs.
abstract: It has now been established that there is an interaction between the cardiovascular control systems and opiate substances. To assess the role of endogenous opiates in the long-term control of blood pressure, the opiate antagonist naloxone (0.5 mg/kg/24 h) was infused intravenously for 7 days. Chronic blockade of endogenous opiates resulted in an elevation in arterial blood pressure which averaged 11% and was sustained throughout the infusion period. This was accompanied by a significant decrease in plasma renin activity averaging -59%. These data provide support for a tonic role of opioids in the long-term control of the cardiovascular system which may involve baroreceptor function.
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D004285:Dogs; D004837:Epinephrine / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D009638:Norepinephrine / Q000097:blood; D012083:Renin / Q000097:blood
chemical_list: D001127:Arginine Vasopressin; D009270:Naloxone; D012083:Renin; D009638:Norepinephrine; D004837:Epinephrine