Sorption of 5-fluorouracil from aqueous solutions onto methyl methacrylate nanoparticles.
The sorption of 5-fluorouracil from aqueous solutions onto poly(methyl methacrylate) was investigated. Linear sorption isotherms were obtained and no crystallinity of the nanoparticles after sorption was detectable by X-ray analysis indicating a partitioning of the drug into the polymer particles-forming a solid solution. Standard enthalpy, standard entropy and standard free energy of sorption were -36.9 kJ mol-1, -85.0 J mol-1 K-1 and -12.0 kJ mol-1, respectively.
D004339:Drug Compounding / Q000379:methods*; D005472:Fluorouracil / Q000008:administration & dosage*; D020366:Methylmethacrylate; D008768:Methylmethacrylates
D008768:Methylmethacrylates; D020366:Methylmethacrylate; D005472:Fluorouracil