title: Silver acetate gum as a deterrent to smoking.
abstract: Silver acetate chewing gum, a nonprescription medication, produces an unpleasant metallic taste in the mouth of individuals who consume tobacco products in conjunction with this smoking deterrent. Use of the product leads to self-induced aversive conditioning. In the present double-blind controlled study, subjects using silver acetate for three weeks of treatment had a smoking cessation rate of 15 out of 136 (11 percent, p = 0.02). Placebo subjects had a smoking cessation rate of 6 out of 146 (4 percent, p = .102). Without further treatment, the group using silver acetate demonstrated a 7 percent nonsmoking rate at four months compared with a 3 percent nonsmoking rate for the placebo group. Silver acetate demonstrated a modest benefit over placebo as a smoking deterrent in a minimal intervention and highly cost-effective treatment setting.
mesh_terms: D000085:Acetates / Q000627:therapeutic use*; D000328:Adult; D002638:Chewing Gum; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D004366:Nonprescription Drugs / Q000627:therapeutic use; D010352:Patient Dropouts; D010919:Placebos; D012834:Silver / Q000627:therapeutic use*; D000074606:Smoking Prevention; D013997:Time Factors
chemical_list: D000085:Acetates; D002638:Chewing Gum; D004366:Nonprescription Drugs; D010919:Placebos; D012834:Silver