Lattice dystrophy of the cornea. A clinical and histopathologic study.
Four members of a family were affected with lattice dystrophy of the cornea. One of them showed recurrence of the disease in the corneal graft in one eye 9 years after a keratoplasty, and a very advanced stage of the disease in the fellow eye. Therefore a keratoplasty was done in this eye. The corneal button was thoroughly investigated by means of histochemistry, electron microscopy and X-ray electron microanalysis. Two young members of the family showing early signs of the disease were followed up for 2 years. It has been possible to observe the evolution of their lesions. Histopathological examinations revealed the presence of two different types of abnormal deposits under the epithelium and in the stroma. X-ray electron microanalysis of the stromal deposits revealed a substantial increase in sulphur content.
D000293:Adolescent; D000682:Amyloid / Q000378:metabolism; D002648:Child; D002869:Chromosome Aberrations / Q000235:genetics* / Q000601:surgery; D025063:Chromosome Disorders; D003094:Collagen / Q000378:metabolism; D003315:Cornea / Q000473:pathology; D003317:Corneal Dystrophies, Hereditary / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D003319:Corneal Stroma / Q000473:pathology; D016039:Corneal Transplantation; D004577:Electron Probe Microanalysis; D004848:Epithelium / Q000473:pathology; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010375:Pedigree; D012008:Recurrence
D000682:Amyloid; D003094:Collagen