title: Control of larynx during loaded breathing in normal subjects.
abstract: We examined laryngeal resistance (Rla) in six normal subjects in control and four kinds of loaded breathing: hypercapnia, chest strapping, added external resistance, and inhaled methacholine. Rla was measured with a low-frequency sound methed (Sekizawa et al., J. Appl. Physiol. 55: 591-597, 1983). In control and the four kinds of loaded breathing, changes in Rla were tightly coupled with ventilation and Rla decreased during inspiration and increased during expiration. Hypercapnia and chest strapping significantly decreased Rla in both inspiration and expiration in all subjects. Added external resistance decreased inspiratory Rla in all subjects, but decreased expiratory Rla in three subjects, did not change it in two subjects, and increased it in one subject. Inhaled methacholine increased Rla in both inspiration and expiration in all subjects. The present study suggests that although laryngeal movement is tightly coupled with ventilation, laryngeal aperture may be determined by the complex competition of dilating and constricting mechanisms associated with the activity of the respiratory center and neural reflexes from the airway.
mesh_terms: D000328:Adult; D000336:Aerosols; D003250:Constriction; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology; D007830:Larynx / Q000502:physiology* / Q000503:physiopathology; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000494:pharmacology; D012119:Respiration; D013909:Thorax; D013990:Tidal Volume; D013997:Time Factors; D014939:Work of Breathing / Q000187:drug effects
chemical_list: D000336:Aerosols; D008688:Methacholine Compounds; D016210:Methacholine Chloride