title: Adipose tissue metabolism in sheep: response to season and its modulation by reproductive state.
abstract: Seasonal changes in subcutaneous adipose tissue metabolism and serum metabolite and hormone concentrations are described in virgin ewes fed a fixed amount of a cereal mixture plus hay ad libitum. Body weight, adipocyte mean cell volume, the rates of fatty acid and acylglycerol glycerol synthesis, and lipoprotein lipase activity increased from October to May and then decreased over the following five months. These changes are probably due to an increase in voluntary food intake leading to increased availability of acetate for fatty acid synthesis and also a probable rise in serum insulin concentration. Seasonal changes in adipose tissue metabolism in sheep are modulated by pregnancy and lactation, possibly mediated in part by changes in the serum insulin: growth hormone ratio. Although seasonal changes in adipose tissue metabolism are paralleled by changes in serum prolactin concentration, prolactin probably does not have a direct effect on adipose tissue metabolism.
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D005260:Female; D006728:Hormones / Q000097:blood; D007328:Insulin / Q000097:blood; D007774:Lactation; D008055:Lipids / Q000096:biosynthesis; D011247:Pregnancy; D012098:Reproduction; D012621:Seasons; D012756:Sheep
chemical_list: D006728:Hormones; D007328:Insulin; D008055:Lipids