title: Stable isotopes of lithium: dissimilar biochemical and behavioral effects.
abstract: Lithium, which is used routinely in the treatment of mania, is composed of two stable isotopes, lithium-7 (92.58%) and lithium-6 (7.42%). Usually there is minimal physiological or biochemical differentiation between isotopes of an element, but lithium is an exception. Data derived from a variety of biochemical and behavioral experiments are reviewed to support this idea. Additionally, the clinical implications of this work are presented.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001714:Bipolar Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D007554:Isotopes; D007700:Kinetics; D008094:Lithium / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D011247:Pregnancy
chemical_list: D007554:Isotopes; D008094:Lithium