title: Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human.
abstract: Murine and human cDNAs, related to but distinct from c-raf-1, have been isolated and designated mA-raf and hA-raf, respectively. The mA-raf and hA-raf cDNAs detect the same murine and human fragments in Southern blots of restriction enzyme-cleaved murine and human cellular DNA. The murine restriction enzyme fragments homologous to mA-raf cDNA cosegregate with mouse chromosome X in a panel of Chinese hamster-mouse hybrid cells, thus localizing the mA-raf locus to mouse chromosome X. Two independently segregating loci, detected by the hA-raf cDNA (or mA-raf cDNA), hA-raf-1 and hA-raf-2, are located on human chromosomes X and 7, respectively. The mA-raf locus and the hA-raf-1 locus are actively transcribed in several mouse and human cell lines.
mesh_terms: D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D009693:Nucleic Acid Hybridization; D011518:Proto-Oncogene Proteins; D011519:Proto-Oncogenes; D014158:Transcription, Genetic; D014960:X Chromosome
chemical_list: D011518:Proto-Oncogene Proteins