Lectin binding to normal human endometrium.
Avidin-biotin-peroxidase labelling technique was used to localize the binding sites of peanut agglutinin (PNA), Ulex europaeus (UEA-I), wheat germ agglutinin (WGA), concanavalin A (Con A), and Ricinus communis (RCA-I) in 30 samples of endometrium at different stages of the menstrual cycle and in early pregnancy. PNA and UEA-I exhibit weak binding to the apical portions of epithelial cells in proliferative and secretory phases, but become strongly positive in pregnancy. WGA and RCA-I show weak binding to glandular epithelium in the proliferative phase, but increase their affinity in the secretory phase. Con A demonstrates strong affinity to decidual cells.
D003208:Concanavalin A / Q000378:metabolism; D004717:Endometrium / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D037102:Lectins / Q000378:metabolism; D008593:Menopause; D008597:Menstrual Cycle; D019887:Peanut Agglutinin; D037121:Plant Lectins; D011247:Pregnancy; D011975:Receptors, Mitogen / Q000378:metabolism*; D014909:Wheat Germ Agglutinins
D037102:Lectins; D019887:Peanut Agglutinin; D037121:Plant Lectins; D011975:Receptors, Mitogen; C017707:Ricinus communis agglutinin-1; C036850:Ulex europaeus lectins; D014909:Wheat Germ Agglutinins; D003208:Concanavalin A