A pilot study of high dose abdominopelvic radiotherapy following surgery and chemotherapy for stage III epithelial carcinoma of the ovary.
Ten patients with FIGO stage III carcinoma of the ovary received abdominopelvic radiotherapy using the abdominal bath technique in combination with surgery and intravenous cyclophosphamide and cis-platinum. The mean midplane dose to the abdominal cavity was 3120 cGy which is significantly higher than other series. Despite this high dose, there was no serious morbidity from radiation hepatitis, enteritis, and nephritis, and the treatment was tolerable. The actuarial survival of the group at 37 months was 30%.
D000206:Actuarial Analysis; D000328:Adult; D002277:Carcinoma / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D002945:Cisplatin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D010865:Pilot Projects; D011446:Prospective Studies
D003520:Cyclophosphamide; D002945:Cisplatin