title: [Mid C regional parathyroid hormone in the clinical workup: diagnostic value in extrarenal (primary) and renal (secondary) hyperparathyroidism].
abstract: The selective determination of mid-C-regional parathyroid hormone (mid-C-PTH) in combination with other laboratory parameters is a reliable tool for diagnosis and treatment of extra-renal (primary) and renal (secondary) hyperparathyroidism. Early stages, which show either high-to-normal serum calcium and elevated mid-C-PTH or increased serum calcium but normal mid-C-PTH, can be distinguished from overt hyperparathyroidism. Alkaline phosphatase (AP) activity and mid-C-regional PTH provide biochemical confirmation of histologically classified renal osteodystrophy. Since the index AP X PTH signifies osseous changes in dialysis patients at an early stage, therapeutic regimens may be altered without additional invasive procedures. After renal transplantation mid-C-PTH normalizes and serum creatinine decreases. Increased mid-C-PTH in patients with normal renal graft function reflects autonomous PTH secretion, which requires careful monitoring to prevent PTH-induced hypercalciuria.
mesh_terms: D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000175:diagnosis* / Q000201:enzymology; D003404:Creatinine / Q000097:blood; D006084:Graft Rejection; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis* / Q000201:enzymology; D006962:Hyperparathyroidism, Secondary / Q000175:diagnosis* / Q000201:enzymology; D007676:Kidney Failure, Chronic / Q000175:diagnosis; D016030:Kidney Transplantation; D010281:Parathyroid Hormone / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011183:Postoperative Complications / Q000175:diagnosis
chemical_list: D010281:Parathyroid Hormone; D010446:Peptide Fragments; D003404:Creatinine
vernacular_title: Mitt-C-regionales Parathormon in der klinischen Routine: Diagnostische Wertigkeit beim extrarenalen (primären) und renalen (sekundären) Hyperparathyreodismus.