Neonatal treatment with capsaicin influences hormonal regulation of blood pressure in adult, water-deprived Long-Evans but not Brattleboro rats.
Conscious, adult, water-deprived Brattleboro rats treated neonatally with capsaicin or vehicle showed similar hypotensive responses to sequential inhibition of the renin-angiotensin system (with captopril) and antagonism of ganglionic transmission (with pentolinium). Following a comparable experimental protocol, Long-Evans rats treated neonatally with capsaicin showed a more marked hypotensive response to captopril administration than did vehicle-injected animals. Furthermore, following administration of captopril and pentolinium, the capsaicin-treated animals showed marked impairment of the vasopressin-dependent recovery of blood pressure. These results indicate that the greater hypotensive response to captopril in water-deprived. Long-Evans rats treated neonatally with capsaicin may be due to less effective compensation for inhibition of the renin-angiotensin system when vasopressin release is impaired.
D000818:Animals; D000831:Animals, Newborn; D001127:Arginine Vasopressin / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects*; D002211:Capsaicin / Q000494:pharmacology*; D002216:Captopril / Q000494:pharmacology*; D004347:Drug Interactions; D010425:Pentolinium Tartrate / Q000494:pharmacology; D051381:Rats; D011910:Rats, Brattleboro; D012084:Renin-Angiotensin System / Q000187:drug effects; D014868:Water Deprivation
D001127:Arginine Vasopressin; D010425:Pentolinium Tartrate; D002216:Captopril; D002211:Capsaicin