The chemistry, mechanism of action and biological properties of CC-1065, a potent antitumor antibiotic.
D000225:Adenine / Q000378:metabolism; D000478:Alkylation; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D002453:Cell Cycle / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair / Q000187:drug effects; D000080890:Duocarmycins; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles; D007928:Lethal Dose 50; D007933:Leucomycins / Q000096:biosynthesis* / Q000378:metabolism / Q000627:therapeutic use / Q000633:toxicity; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D013237:Stereoisomerism
D000080890:Duocarmycins; D007211:Indoles; D007933:Leucomycins; C018782:CC 1065; D004247:DNA; D000225:Adenine