Inactivation of GABA aminotransferase by 3-nitro-1-propanamine.
3-Nitro-1-propanamine is a close structural analog of the neuro-transmitter GABA. The nitro compound is a good substrate for the GABA aminotransferase from porcine brain. However, it inactivates the GABA aminotransferase from GABA-grown Pseudomonas fluorescens in a slowly reversible reaction. Both enzymes are inactivated by the homolog 4-nitro-1-butanamine.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D007700:Kinetics; D011437:Propylamines / Q000494:pharmacology*; D013552:Swine
D011437:Propylamines; C059945:3-nitro-1-propylamine; D000612:4-Aminobutyrate Transaminase