Search for CEA-like molecules in polymorphonuclear leukocytes of non-human primates using monoclonal antibodies.
The monoclonal anti-CEA antibody ZIK-A42-A/C1 which reacts with NCA of human polymorphonuclear leukocytes was found to bind also to polymorphonuclear blood leukocytes of the following non-human primates tested: hamadryas baboon (Papio hamadryas), stump-tailed monkey (Macaca arctoides), pig-tailed monkey (Macaca nemestrina), and rhesus monkey (Macaca mulata). No binding was observed to mononuclear blood leukocytes. It was concluded that non-human primates contain CEA-like substances in their polymorphonuclear leukocytes as humans do and that these substances carry some identical epitopes.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D002478:Cells, Cultured; D007158:Immunologic Techniques; D008251:Macaca; D008253:Macaca mulatta; D008254:Macaca nemestrina; D009504:Neutrophils / Q000276:immunology*; D010215:Papio; D011323:Primates / Q000276:immunology*
D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen