Effect of clonidine on plasma cortisol concentrations.
There is a debate whether the fall in plasma cortisol concentrations after the early morning dosing of clonidine represents drug effect or normal diurnal variation. We compared the cortisol patterns of children after a 7:30 AM oral dose of clonidine (0.075 or 0.150 mg/m2) with the cortisol concentrations that resulted from diurnal variation. Some subjects had the diurnal study on day 1 and the clonidine study on day 2, whereas for others the testing sequence was reversed. Our results indicate that clonidine, in either dose, does not cause a fall in plasma cortisol levels greater than that with normal diurnal variation.
D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002940:Circadian Rhythm; D003000:Clonidine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007003:Hypoglycemia / Q000378:metabolism; D007328:Insulin / Q000009:adverse effects; D008297:Male; D011863:Radioimmunoassay
D007328:Insulin; D003000:Clonidine; D006854:Hydrocortisone