Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in exfoliated cells.
The molar ratio between a diene-conjugated linoleic-acid isomer (18:2(9,11)) and the parent linoleic acid (18:2(9,12)), both esterified as phospholipids, was significantly different in exfoliated cells from normal cervices and from cervices with colposcopic and cytological evidence of precancer. The measurement may provide a simple and perhaps improved alternative to cytological screening.
D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D005609:Free Radicals; D006801:Humans; D008041:Linoleic Acids / Q000032:analysis*; D044243:Linoleic Acids, Conjugated; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D005609:Free Radicals; D008041:Linoleic Acids; D044243:Linoleic Acids, Conjugated; C046938:9,11-linoleic acid