title: The eosinophilic variant of acute myelomonocytic leukemia developing as a secondary leukemia in a patient with mycosis fungoides.
abstract: The eosinophilic variant of acute myelomonocytic leukemia (AMML) is highly associated with characteristic abnormalities of chromosome 16. Leukemias developing secondary to chemotherapy frequently show abnormalities of chromosomes 5 and 7. This report describes a secondary AMML, eosinophilic variant (M4Eo), developing in a patient with coexistent mycosis fungoides who had received chemotherapy, including an alkylating agent, and showing characteristic abnormalities of both chromosomes 7 and 16. This is the first reported case of the M4Eo arising secondarily in a patient treated for another hematopoietic malignancy, and the second case of treatment-induced M4Eo to show coexistent abnormalities of chromosomes 7 and 16. Additional cytochemical, ultrastructural, and cell surface marker findings are described supporting malignant transformation of the eosinophilic cell line.
mesh_terms: D000328:Adult; D000954:Antigens, Surface / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology / Q000648:ultrastructure; D002885:Chromosomes, Human, Pair 16; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D015472:Leukemia, Eosinophilic, Acute / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications / Q000235:genetics / Q000473:pathology*; D009182:Mycosis Fungoides / Q000150:complications*
chemical_list: D000954:Antigens, Surface