title: Impairment of renal slice function following brain death, with reversibility of injury by hormonal therapy.
abstract: The effects of the agonal period and subsequent donor management on renal slice function, using the K+ - Na+ ratio, have been studied in the pig. Brain ischaemia or death resulted in a reduction in renal slice function, whether the pig was maintained normovolemic or hypovolemic by i.v. fluid and dobutamine therapy. This deterioration in function was, however, reversed or prevented by a period of therapy with thyroxine (T3), insulin, and cortisol. A period of 24 hr storage of the kidney slice in a low ionic strength solution in ice resulted in a further deterioration in slice function in all groups studied.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001926:Brain Death / Q000503:physiopathology*; D002545:Brain Ischemia / Q000503:physiopathology; D003080:Cold Temperature; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D011188:Potassium / Q000032:analysis; D012964:Sodium / Q000032:analysis; D013552:Swine; D013974:Thyroxine / Q000494:pharmacology*; D014021:Tissue Preservation / Q000009:adverse effects
chemical_list: D007328:Insulin; D012964:Sodium; D013974:Thyroxine; D011188:Potassium; D006854:Hydrocortisone