Mechanism of resistance to silver ions in Klebsiella pneumoniae.
The uptake of silver by an experimentally derived silver-resistant Klebsiella pneumoniae strain was three to four times lower than the uptake by a susceptible strain. Spheroplasts of the two strains showed no difference in uptake. AgNO3 at a concentration of 40 micrograms/ml decreased the succinate dehydrogenase activity in susceptible and resistant strains by 100 and 18%, respectively. More than one resistance mechanism may be involved.
D004352:Drug Resistance, Microbial; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000378:metabolism; D012834:Silver / Q000378:metabolism / Q000494:pharmacology*; D013104:Spheroplasts / Q000187:drug effects; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors
D012834:Silver; D013385:Succinate Dehydrogenase