[Methodologic problems in studying cardiologic drugs].
Methodological difficulties arising on studying clinical efficacy of novel antiarrhythmic and antianginal drugs are discussed. Combined data on the evaluation of the action of the drugs are presented. The comparison of the results obtained in an acute drug test and during course treatment indicates the agreement of the data on efficacy of the absolute majority of antianginal and antiarrhythmic drugs. The interaction of propranolol and nifedipine was taken as an example to show that despite an opposite character of the pharmacodynamic action potentiation of the effect is observed. The author believes that the final determination of the drug value can be given only following the assessment of its effect on long-term outcomes.
D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000379:methods; D004562:Electrocardiography; D006801:Humans; D010919:Placebos
D002317:Cardiovascular Agents; D010919:Placebos
Metodicheskie voprosy izucheniia kardiologicheskikh lekarstvennykh sredstv.