title: Prophylactic antibiotics in transurethral resection of bladder tumors: are they necessary?
abstract: In a double-blind study, 30 patients having transurethral surgery for bladder tumors were randomly assigned to receive prophylactic carbenicillin indanyl sodium or a placebo perioperatively. Only one patient in the carbenicillin group had a postoperative urinary infection due to carbenicillin-resistant Klebsiella oxytoca organisms. Thus, no advantage from the prophylactic use of antibiotics was evident in this uninfected group of patients.
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002228:Carbenicillin / Q000031:analogs & derivatives / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D001749:Urinary Bladder Neoplasms / Q000601:surgery*; D014552:Urinary Tract Infections / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D010919:Placebos; C100244:carbenicillin indanyl; D002228:Carbenicillin