title: [Characteristics of the immune response of inoculated and intact animals to the administration of toxigenic and nontoxigenic strains of Clostridium tetani].
abstract: In experiments on guinea pigs the immune reactions of the animals immunized and not immunized against tetanus in response to the injection of C. tetani spores were studied. In the immunized animals an increase in the production of tetanus antitoxin, the development of delayed hypersensitivity and the activation of the mechanisms of cell-mediated immunity were observed. The nonimmunized animals showed specific changes in the T-system of immunity without the appearance of the clinical symptoms of tetanus, which is, probably, one of the mechanisms of natural immunity.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003017:Clostridium tetani / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D007958:Leukocyte Count / Q000187:drug effects; D013171:Spores, Bacterial / Q000276:immunology; D013742:Tetanus / Q000276:immunology*; D013743:Tetanus Antitoxin / Q000032:analysis; D013744:Tetanus Toxin / Q000633:toxicity*; D013997:Time Factors
chemical_list: D013743:Tetanus Antitoxin; D013744:Tetanus Toxin
vernacular_title: Kharakteristika immunnogo otveta privitykh i intaktnykh éksperimental'nykh zhivotnykh na vvedenie toksigennogo i netoksigennogo shtammov Clostridium tetani.