More on the need for circadian, circaseptan and circannual optimization of cyclosporine therapy.
Cyclosporine chronotherapy of pancreas-allotransplanted rats revealed, beyond a circadian stage-dependence of equal daily doses, further gain in graft function from doses varying from day to day with an about 7-day periodicity, the first highest dose being given on the 3rd or 5th day after surgery.
D000818:Animals; D002940:Circadian Rhythm; D003524:Cyclosporins / Q000008:administration & dosage* / Q000627:therapeutic use; D006084:Graft Rejection; D006085:Graft Survival; D016027:Heart Transplantation; D016030:Kidney Transplantation; D008297:Male; D016035:Pancreas Transplantation; D010507:Periodicity; D051381:Rats; D011917:Rats, Inbred Lew
D003524:Cyclosporins