[Reversible panmyelopathy following captopril treatment].
In a 46-year-old female patient suffering from renal hypertension due to polycystic kidney degeneration with creatinine values between 3 and 5 mg/dl leucopenia developed 3 weeks after beginning antihypertensive therapy with the angiotensin-converting-enzyme inhibitor captopril. On continuation of treatment signs of haemorrhagic diathesis appeared 7 months later. Cytology and histology led to the diagnosis of panmyelopathy which, from the clinical findings and the close patient follow-up, was to be regarded as captopril-induced. Bone-marrow regeneration could be shown 6 months after discontinuing the drug. In renal insufficiency, captopril treatment should be monitored using regular haematological tests and the drug withdrawn when leuco- or thrombocytopenia occurs.
D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D002216:Captopril / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000188:drug therapy; D008875:Middle Aged; D012038:Regeneration
D002216:Captopril
Reversible Panmyelopathie nach Captopril-Medikation.