Cadmium stimulates glucose metabolism in rat adipocytes.
Cd2+ caused an increase in CO2 formation from glucose in rat adipocytes. The apparent Km value for glucose was 2.02 mM for control condition, with Cd2+, and with insulin. Cd2+ stimulates glucose metabolism even though specific diffusion of glucose is blocked. A possible site effected by Cd2+ is discussed.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D003571:Cytochalasin B / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects*; D007328:Insulin / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D008345:Manganese / Q000494:pharmacology; D009532:Nickel / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium; D015032:Zinc / Q000494:pharmacology
D002250:Carbon Radioisotopes; D007328:Insulin; D002104:Cadmium; D014316:Tritium; D003571:Cytochalasin B; D008345:Manganese; D009532:Nickel; D005947:Glucose; D015032:Zinc