Attempted isolation of viruses from myasthenia gravis thymus.
A systematic study of thymus homogenates and cell suspensions from 13 patients with myasthenia gravis (MG) of recent onset, and 6 non-myasthenic controls, has failed to detect or isolate virus by cell culture with 'rescue techniques', electron microscopy, or intracerebral inoculation into neonatal mice. These results do not support the case for persistent viral infection in the thymus, and impose constraints on hypotheses of a viral aetiology of MG.
D000293:Adolescent; D000328:Adult; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000382:microbiology; D002460:Cell Line; D002648:Child; D002522:Chlorocebus aethiops; D003168:Complement Fixation Tests; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D009157:Myasthenia Gravis / Q000209:etiology / Q000382:microbiology*; D010215:Papio; D011817:Rabbits; D013950:Thymus Gland / Q000382:microbiology* / Q000648:ultrastructure; D014777:Virus Diseases / Q000150:complications*
D000956:Antigens, Viral