Prevention of histamine-induced cardiovascular reactions during the induction of anaesthesia following premedication with H1- + H2-antagonists i.m.
In a prospective controlled double-blind study, 60 elective surgical patients were randomly assigned to three premedication groups. Twenty patients received promethazine 0.5 mg kg-1 i.m. 45 min before induction of anaesthesia; a further 20 patients received an additional i.m. injection of cimetidine 400 mg 120 min before induction. The third group (n = 20) served as the control group. Following vecuronium 0.02 mg kg-1, anaesthesia was induced with fentanyl, and etomidate. All patients then received suxamethonium 1.5 mg kg-1 i.v. The combined administration of H1- + H2-antagonists as premedication led to a significant reduction in the increase in heart rate when compared with the effects in the other groups.
D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D002927:Cimetidine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004342:Drug Hypersensitivity / Q000517:prevention & control*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000517:prevention & control*; D008875:Middle Aged; D011292:Premedication; D011398:Promethazine / Q000627:therapeutic use; D011446:Prospective Studies; D013390:Succinylcholine / Q000009:adverse effects*
D002927:Cimetidine; D011398:Promethazine; D013390:Succinylcholine