The pyrogallol related compounds reduce UV-induced mutations in Escherichia coli B/r WP2.
Plant components with bio-antimutagenic activity were screened on UVC (254 nm)-induced mutagenesis using E. coli B/r WP2. The components with a pyrogallol moiety including gallic acid, (-)-epicatechin gallate (ECG), (-)-epigallocatechin (EGC) and (-)-epigallocatechin gallate (EGCG) reduced the mutation induction, but other components such as caffeic acid, chlorogenic acid and quercetin did not. The above compounds with a pyrogallol moiety were also effective on UVAB (295-400 nm)-induced mutagenesis, while they showed little effect on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced mutagenesis. As this bio-antimutagenic effect was not seen in the DNA excision-repair-deficient strains WP2s and ZA159, the activity by the above plant components might be based on the promotion of the excision-repair system in E. coli B/r WP2.
D004926:Escherichia coli / Q000235:genetics*; D005707:Gallic Acid / Q000494:pharmacology; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D009152:Mutagenicity Tests; D009154:Mutation; D011748:Pyrogallol / Q000031:analogs & derivatives / Q000494:pharmacology*; D014466:Ultraviolet Rays
D011748:Pyrogallol; D008769:Methylnitronitrosoguanidine; D005707:Gallic Acid