title: Levels of IgE in serum from normal children and allergic children as measured by an enzyme immunoassay.
abstract: Serum IgE levels of 346 nonallergic and 301 allergic children were measured by an enzyme immunoassay. The data are presented as the geometric mean +/- 95% confidence interval for each age from less than 1 to 12 years of age with those 13 to 16 years of age, pooled. The geometric mean for nonallergic patients increases from 0.9 IU/ml at less than 1 year of age to 45.4 IU/ml at 13 to 16 years of age. By use of an IgE value between confidence intervals of allergic and nonallergic subjects, a cutoff value for each age was established to differentiate allergic from nonallergic children. This value increases from 10 IU/ml at less than 1 year to 100 IU/ml at 13 to 16 years of age. The diagnostic sensitivity and specificity of the assay, based on the cutoff values, average 83% and 91%, respectively.
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007124:Immunoenzyme Techniques; D007073:Immunoglobulin E / Q000032:analysis*; D007223:Infant; D008297:Male; D008800:Mexico; D013548:Sweden; D014481:United States; D014687:Venezuela
chemical_list: D007073:Immunoglobulin E