Prophylaxis of complications after urological abdominal surgery by substitution of plasma proteins.
A prospective randomized trial on 94 patients undergoing urological-abdominal surgery has been carried out to evaluate the effect of postoperatively administered plasma proteins. A significant difference in the incidence of bronchopulmonary complications has been found between the treatment group and the control group. This may be due to the substitution of alpha 1-antitrypsin as indicated by assaying alpha-antitrypsin activity. A positive trend, but no significant differences, could be demonstrated for wound healing and the need for antibiotics, postoperatively.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001798:Blood Proteins / Q000627:therapeutic use*; D001803:Blood Transfusion; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D011897:Random Allocation; D014570:Urologic Diseases / Q000601:surgery*; D014945:Wound Healing; D000515:alpha 1-Antitrypsin / Q000032:analysis
D000900:Anti-Bacterial Agents; D001798:Blood Proteins; D000515:alpha 1-Antitrypsin