Polylactic acid microspheres containing quinidine base and quinidine sulphate prepared by the solvent evaporation technique. I. Methods and morphology.
D,1-polylactic acid (PLA) microspheres containing the antiarrhythmic drug, quinidine, were prepared by the solvent evaporation method. The drug was present as either the base or as the sulphate salt. A slight modification in the process resulted in high yields of free-flowing, non-aggregated microspheres. The successful entrapment of drug within the microspheres was highly dependent on drug solubility in the aqueous phase. Diffusion and drug loss to the aqueous phase was minimized by adjusting the pH of the aqueous phase to minimal drug solubility. Saturation of the aqueous phase with drug further improved the payload of the microspheres. The appearance of the microsphere surface depended on the pH of the aqueous phase, the electrolyte concentration, and the type and amount of drug present. Structural changes and erosion of the polymer were observed at high pH-values.
D006863:Hydrogen-Ion Concentration; D007773:Lactates; D019344:Lactic Acid; D008863:Microspheres; D011091:Polyesters; D011108:Polymers; D011802:Quinidine / Q000008:administration & dosage*; D012995:Solubility; D013431:Sulfates; D014835:Volatilization
D007773:Lactates; D011091:Polyesters; D011108:Polymers; D013431:Sulfates; D019344:Lactic Acid; C033616:poly(lactide); D011802:Quinidine