Effects of systemic glucocorticoids on the degradation of glycosaminoglycans in the mandibular condylar cartilage of newborn mice.
This investigation studied the early in vivo effects of triamcinolone hexacetonide, a potent fluorinated analogue of cortisol, on the degradation of sulfated proteoglycans in condylar cartilage of newborn mice. While determining the rate of [35S]sulfate release in test and control specimens, it became evident that in hormone-treated animals there was a dose-dependent retardation of the isotope clearance. Further, triamcinolone was found to have increased the half-life of condylar glycosaminoglycans (GAGs) from 16 h in control animals to 31.4 h in hormone-treated ones. Dexamethasone, another fluorinated analogue of cortisol, and progesterone evoked a similar effect. On the other hand, hydrocortisone and cortisone induced a much milder effect, whereas the non-glucocorticoid steroid deoxycorticosterone did not affect the turnover of radiosulfate in this tissue. Clearance of the isotope from the serum was faster in the hormone-treated animals. Further, the hormone led to a decrease in the overall content of GAGs, a feature that lasted for 24 h. These data tend to imply that, concomitant with the inhibitory effects of glucocorticoids on proteoglycan synthesis in cartilage, they also induce a transient depressive effect upon the degradation of proteoglycans and thereby interfere with the normal growth and development of this cartilage.
D000818:Animals; D000831:Animals, Newborn; D002356:Cartilage / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D003348:Cortisone / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology*; D006025:Glycosaminoglycans / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology; D008335:Mandibular Condyle / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008813:Mice, Inbred ICR; D011509:Proteoglycans / Q000378:metabolism; D013431:Sulfates / Q000378:metabolism; D014222:Triamcinolone Acetonide / Q000031:analogs & derivatives / Q000494:pharmacology
D005938:Glucocorticoids; D006025:Glycosaminoglycans; D011509:Proteoglycans; D013431:Sulfates; D003907:Dexamethasone; D014222:Triamcinolone Acetonide; C005900:triamcinolone hexacetonide; D003348:Cortisone; D006854:Hydrocortisone