[Treatment of congestive heart failure: new concepts].
In the past, hemodynamic factors, in congestive heart failure were considered as being of major importance in the production of the major symptoms and signs of the disease: peripheral (increased oxygen extraction, flow redistribution) or central (Starling's law, myocardial contractility). More recently, excessive hormonal compensation has been felt to be more important such as: The renine-angiotensin-aldosterone axis, Circulating catecholamines, Arginin-vasopressin. These hormones are responsible for water and sodium retention, tachycardia and increase in peripheral resistance. Newer agents such as Captopril are effective in blocking the action of these endocrine factors.
D001127:Arginine Vasopressin / Q000378:metabolism; D002216:Captopril / Q000627:therapeutic use*; D002395:Catecholamines / Q000378:metabolism; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D012084:Renin-Angiotensin System; D014655:Vascular Resistance; D014882:Water-Electrolyte Balance
D002395:Catecholamines; D001127:Arginine Vasopressin; D002216:Captopril
Le traitement de l'insuffisance cardiaque: nouveaux concepts.