Phenyl-T-butyl-nitrone is active against traumatic shock in rats.
Oxygen free-radicals appear to be involved in the pathogenesis of shock; therefore trapping of these radicals would modify the evolution of experimental shock. Experiments were performed on rats submitted to 100% lethal whole body trauma (rotating drum) and their survival, pathology, acid-base status and hematocrit level observed. The spin trapping agent phenyl-t-butyl-nitrone (PBN) was administered before trauma (50, 100, 150 mg/kg i.p.) or at various intervals (30, 60 minutes) after establishment of a severe traumatic shock. It appeared that PBN administration was highly effective both in prevention and in reversion of traumatic shock in rats.
D000818:Animals; D003497:Cyclic N-Oxides; D005609:Free Radicals; D009589:Nitrogen Oxides / Q000627:therapeutic use*; D051381:Rats; D012774:Shock, Traumatic / Q000188:drug therapy* / Q000517:prevention & control*
D003497:Cyclic N-Oxides; D005609:Free Radicals; D009589:Nitrogen Oxides; C029217:phenyl-N-tert-butylnitrone