High-frequency jet ventilation during pneumothorax in dogs.
Pneumothorax (45 ml of N/kg of body weight insufflated into the pleural space) in anesthetized dogs ventilated with air caused a significant (P less than 0.05) increase in pleural pressure, central venous pressure, capillary wedge pressure, and venous admixture. Cardiac index (CI) and arterial O2 tensions were decreased. Ventilation with 100% O2 increased arterial O2 tensions, but did not affect calculated intrapulmonary shunting of blood or CI. Application of 10 cm of H2O-positive end-expiratory pressure in the presence of pneumothorax during positive-pressure ventilation and high-frequency jet ventilation reduced intrapulmonary shunting of blood, which remained higher than control values, and caused a further decrease in CI. Cardiopulmonary function during pneumothorax in anesthetized dogs was more profoundly affected by the application of positive end-expiratory pressure than by the form of mechanical ventilation.
D000818:Animals; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs; D008297:Male; D011030:Pneumothorax / Q000503:physiopathology / Q000662:veterinary*; D011175:Positive-Pressure Respiration / Q000662:veterinary*; D011652:Pulmonary Circulation; D012121:Respiration, Artificial / Q000662:veterinary