Aneuploidy-inducing chemicals in yeast evaluated by the micronucleus test.
Chinese hamsters were exposed to acetone, methyl ethyl ketone, ethyl acetate and 2-methoxy ethyl acetate, known to be strong inducers of aneuploidy in the yeast Saccharomyces cerevisiae. All solvents yielded negative results in the micronucleus test, whereas the vinca alkaloid vindesine--used as a positive control substance--proved to act as a spindle poison in mammals in vivo.
D000085:Acetates / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D000096:Acetone / Q000494:pharmacology; D000782:Aneuploidy; D000818:Animals; D002074:Butanones / Q000494:pharmacology; D002467:Cell Nucleus / Q000648:ultrastructure; D006224:Cricetinae; D005260:Female; D008297:Male; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics; D012997:Solvents / Q000494:pharmacology*; D014751:Vindesine / Q000494:pharmacology
D000085:Acetates; D002074:Butanones; D009153:Mutagens; D012997:Solvents; D000096:Acetone; C048765:2-methoxy ethyl acetate; C005222:methylethyl ketone; C007650:ethyl acetate; D014751:Vindesine