[Effect of enkephalins on various mechanisms regulating glycogen concentration in the liver].
Experiments were staged on 97 outbred albino male rats with the body mass of 180-220 g. The administration of a stable leu-enkephalin analog to the animals did not cause significant changes of the glycogen concentration in the liver but prevented its reduction in response to catecholamines and parathyroid hormone. Simultaneously enkephalin reduced the insulin concentration in the blood. Some mechanisms of the enkephalin effect on the hormonal regulation of carbohydrate metabolism are discussed.
D000818:Animals; D004347:Drug Interactions; D004743:Enkephalin, Leucine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D004837:Epinephrine / Q000008:administration & dosage; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D008099:Liver / Q000187:drug effects*; D008112:Liver Glycogen / Q000032:analysis*; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage; D010281:Parathyroid Hormone / Q000008:administration & dosage; D051381:Rats
D007328:Insulin; D008112:Liver Glycogen; D010281:Parathyroid Hormone; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; D009638:Norepinephrine; D004837:Epinephrine
Vliianie énkefalinov na nekotorye mekhanizmy éndokrinnoĭ reguliatsii soderzhaniia glikogena v pecheni.