Evidence for lipid peroxidation in endotoxin-poisoned mice.
Ethane has been identified and quantitated in air exhaled by mice following intraperitoneal injection of 20, 40, or 200 mg of Escherichia coli O111:B4 lipopolysaccharide (LPS) per kg. Significant increases in ethane concentration occurred within 1 to 5 h after LPS administration. In addition, increased concentrations of malondialdehyde were found in crude homogenates of livers obtained from mice 16 h after administration of 20 mg of LPS per kg. These results suggest that lipid peroxidation may be an important mechanism responsible for LPS toxicity.
D000818:Animals; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D004980:Ethane / Q000378:metabolism; D005260:Female; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008099:Liver / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice
D004731:Endotoxins; D008054:Lipid Peroxides; D008070:Lipopolysaccharides; D008315:Malondialdehyde; D004980:Ethane