[Production in vivo of macrophage migration inhibition and stimulation factors in the inductive phase of the alloimmune response].
Macrophage migration inhibition and stimulation factors were revealed in the serum of alloimmune mice by polyacrylamide gel electrophoresis. CBA mice were primed intravenously with 90 X 10(6) and challenged subsequently intravenously with 20 X 10(6) spleen cells of BALB/c mice. Macrophage migration inhibition and stimulation factors were revealed in pre- and post-albumin fractions, respectively, already on days 1 and 6 after alloimmunization. It is suggested that at an early phase of immune response the immunomediators with alternative functions whose local activity gradients predetermined the macrophage behaviour, are released into the serum of alloimmune animals.
D000818:Animals; D007518:Isoantibodies / Q000096:biosynthesis*; D008262:Macrophage Activation; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA
D007518:Isoantibodies; D008263:Macrophage Migration-Inhibitory Factors
Produktsiia in vivo faktorov podavleniia i stimuliatsii migratsii makrofagov v induktovnoĭ faze alloimmunnogo otveta.