[Analysis of hypotensive and hemodynamic effects of prazosin in patients with hypertension].
The clinical effect of the peripheral vasodilator prazosin (Adwersuten, GDR) was studied in 51 patients with second-stage essential hypertension. A single dose of 1 to 2.5 mg produced hypotensive effect in 48 (94.1%) patients, that lasted between 3 and 4 hours, with the lowest ABP drop occurring 1.5-2.5 hours after the administration. When prazosin was given as a course of monotherapy, its daily dose varied between 3 and 20 mg (6.7 +/- 0.6 mg). A marked hypotensive effect was obtained by the end of the first week in 91.4% of patients. A 28.6% decrease in total peripheral resistance was the principal hemodynamic effect of prazosin. No significant changes of heart rate were recorded on the group basis, while side-effects were noted in 7 (13.7%) patients (orthostatic hypotension and allergic response).
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D011224:Prazosin / Q000008:administration & dosage / Q000627:therapeutic use*; D011433:Propranolol / Q000008:administration & dosage; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D011433:Propranolol; D011224:Prazosin
Analiz gipotenzivnogo i gemodinamicheskogo effekta prazozina u bol'nykh gipertonicheskoĭ bolezn'iu.