Sequelae of induced first-trimester abortion. A prospective study assessing the role of postabortal pelvic inflammatory disease and prophylactic antibiotics.
A follow-up study was undertaken in 493 women who had participated in a clinical, controlled trial with the object of assessing the role of postabortal pelvic inflammatory disease and prophylactic antibiotics in the development of sequelae. Information about dysmenorrhea, dyspareunia, chronic pelvic pain, episodes of pelvic inflammatory disease, infertility, births, induced and spontaneous abortions, and ectopic pregnancies were obtained from 382 of the women and from 38 of 40 women who had contracted postabortal pelvic inflammatory disease during the previous study. Significantly elevated rates in women with postabortal pelvic inflammatory disease compared with women without this disease were found for spontaneous abortion (22% versus 5%, p less than 0.0005), secondary infertility (10% versus 2%, p less than 0.05), dyspareunia (20% versus 5%, p less than 0.005), and chronic pelvic pain (14% versus 2%, p less than 0.001). Nonsignificant differences were observed for ectopic pregnancy and dysmenorrhea. A new episode of pelvic inflammatory disease within the first year after abortion was observed more often in women with postabortal pelvic inflammatory disease than in women without infection (41% versus 5%, p less than 0.0001). Prophylactic antibiotics decreased the rates of spontaneous abortion and dyspareunia (p less than 0.05 in both instances).
D000028:Abortion, Induced / Q000009:adverse effects*; D000022:Abortion, Spontaneous / Q000150:complications; D000667:Ampicillin / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D004414:Dyspareunia / Q000209:etiology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D000292:Pelvic Inflammatory Disease / Q000209:etiology / Q000517:prevention & control*; D010400:Penicillin G / Q000008:administration & dosage*; D010917:Pivampicillin / Q000008:administration & dosage*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011292:Premedication; D011446:Prospective Studies; D012008:Recurrence
D010917:Pivampicillin; D000667:Ampicillin; D010400:Penicillin G