title: [Evaluation of the possibility of using genetic and microbiological research methods for resolving current problems in the epidemiology of salmonellosis].
abstract: S. typhimurium strains isolated in 14 regions of the USSR have, parallel with considerable similarity in their biological characteristics, a number of essential differences. These differences become manifest in the determination of the plasmid spectra of the above organisms. The transfer of R-plasmid PLE518 F1 me fin+ with a molecular weight of 96 Md to strains, sensitive to the action of typing bacteriophages, renders these strains resistant to the lytic action of a number of phages, which leads to the conversion of their phage type. In some cases it may deteriorate the validity of the method of phage typing, used for epidemiological purposes.
mesh_terms: D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors; D001431:Bacteriological Techniques; D001434:Bacteriophage Typing; D003227:Conjugation, Genetic; D004352:Drug Resistance, Microbial; D005821:Genetic Techniques; D006801:Humans; D008826:Microbial Sensitivity Tests; D011815:R Factors; D012107:Research Design; D012480:Salmonella Infections / Q000453:epidemiology* / Q000235:genetics / Q000382:microbiology; D012486:Salmonella typhimurium / Q000145:classification / Q000187:drug effects / Q000235:genetics; D014586:USSR
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Otsenka vozmozhnosti ispol'zovaniia geneticheskikh i mikrobiologicheskikh metodov issledovaniia dlia resheniia aktual'nykh voprosov épidemiologii sal'monellezov.