Incorporation of 3-deoxy-3-fluoro-D-glucose into glycogen and trehalose in fat body and flight muscle in Locusta migratoria.
Flight muscle and fat body extracts from Locusta migratoria were incubated with D-[U-14C]-glucose or D-[3-3H]-3-deoxy-3-fluoroglucose and the products were analyzed. In the case of the latter compound, radio-chromatographic analysis yielded glycogen and trehalose fractions that were shown by 19F nuclear magnetic resonance to contain fluorine. Acid hydrolysis of these fractions liberated tritium labelled 3-deoxy-3-fluoro-D-glucose. In addition to the formation of "fluoroglycogen" and "fluorotrehalose" in these tissue extracts, there was an accumulation of tritium labelled fructose.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism*; D004187:Disaccharides / Q000096:biosynthesis*; D005426:Flight, Animal; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000096:biosynthesis*; D006110:Grasshoppers / Q000378:metabolism*; D007700:Kinetics; D009132:Muscles / Q000378:metabolism; D011865:Radioisotope Dilution Technique; D014199:Trehalose / Q000096:biosynthesis*; D014316:Tritium
D002250:Carbon Radioisotopes; D003837:Deoxy Sugars; D004187:Disaccharides; D014316:Tritium; C007253:3-deoxy-3-fluoro-D-glucose; D006003:Glycogen; D003847:Deoxyglucose; D014199:Trehalose; D005947:Glucose