Studies on improvement of pharmaceutical preparations prescribed in hospitals. II: Study on pharmaceutical manufacturing of dibekacin sulfate gauze tampon.
A gauze tampon, which contains an ointment incorporating dibekacin sulfate, was prepared and investigated as a device to prevent bacterial infection after operation of chronic sinusitis. It was proved that no loss of potency occurred upon heat sterilization and that it was stable even after storage for a long period. This gauze tampon was easy to insert into the paranasal sinuses, achieving satisfactory therapeutic efficacy in terms of hemostasis and disinfection. No adverse reactions have been observed.
D000328:Adult; D002626:Chemistry, Pharmaceutical; D003982:Dibekacin / Q000008:administration & dosage* / Q000032:analysis / Q000627:therapeutic use; D004355:Drug Stability; D004356:Drug Storage; D006761:Hospitals; D006801:Humans; D007612:Kanamycin / Q000031:analogs & derivatives*; D008297:Male; D009824:Ointments; D012852:Sinusitis / Q000601:surgery; D013242:Sterilization; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013630:Tampons, Surgical; D013696:Temperature
D009824:Ointments; D003982:Dibekacin; D007612:Kanamycin