title: International experiences with diclofenac in osteoarthritis.
abstract: Despite a wide range of study designs, a multiplicity of international trials of diclofenac in osteoarthritis have disclosed similar results. These include double-blind comparisons with indomethacin, aspirin, naproxen, ibuprofen, sulindac, and diflunisal, as well as open trials from European field studies. The results of this review document that diclofenac is as effective as other nonsteroidal anti-inflammatory drugs in the treatment of osteoarthritis.
mesh_terms: D001241:Aspirin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004008:Diclofenac / Q000009:adverse effects / Q000627:therapeutic use*; D004061:Diflunisal / Q000627:therapeutic use; D004311:Double-Blind Method; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use; D007213:Indomethacin / Q000009:adverse effects / Q000627:therapeutic use; D009288:Naproxen / Q000627:therapeutic use; D010003:Osteoarthritis / Q000188:drug therapy*; D011897:Random Allocation; D013467:Sulindac / Q000627:therapeutic use
chemical_list: D004008:Diclofenac; D013467:Sulindac; D009288:Naproxen; D004061:Diflunisal; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin