[Causes of hyperinsulinemia and decreased sensitivity to insulin in liver damage].
Chronic contamination of rats with heliotrin causing the development of hepatitis or hepatocirrhosis and partial hepatectomy to decrease the amount of liver cellular elements resulted in intolerance to glucose, a decrease in the sensitivity of the body to insulin, hyperinsulinemia after a glucose-tolerance test. The content of glycogen in the liver of the heliotrin contaminated rats was much lower than that in the controls and after glucose-tolerance an absolute increment of glycogen in the controls was 8.8-fold higher than in the heliotrin-contaminated rats. It was concluded that a decrease in glucose-tolerance and hyperinsulinemia in patients with chronic hepatitis and hepatocirrhosis were determined by a decrease in the amount of functionally active liver cellular elements and the development of insulin resistance.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism*; D002908:Chronic Disease; D005951:Glucose Tolerance Test; D006498:Hepatectomy; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D011763:Pyrrolizidine Alkaloids / Q000009:adverse effects; D051381:Rats
D007328:Insulin; D008112:Liver Glycogen; D011763:Pyrrolizidine Alkaloids; C010178:heliotrine
O prichine giperinsulinemii i snizheniia chuvstvitel'nosti k insulinu pri porazheniiakh pecheni.