Coexistence of calcitonin gene-related peptide and vasoactive intestinal peptide in cholinergic sympathetic innervation of rat sweat glands.
Immunoreactivity for calcitonin gene-related peptide (CGRP) has been localized with indirect immunofluorescence techniques in the cholinergic sympathetic fibers that innervate eccrine sweat glands in the rat. This innervation also contains vasoactive intestinal peptide-like immunoreactivity (VIP-IR). A small proportion of principal neurons in stellate and lumbar sympathetic ganglia which provide innervation to the sweat glands contain detectable CGRP-immunoreactivity. The CGRP-IR neurons are immunoreactive for VIP; however, many VIP-IR neurons in these ganglia do not contain detectable levels of CGRP-IR.
D000818:Animals; D001338:Autonomic Fibers, Postganglionic / Q000378:metabolism; D015740:Calcitonin Gene-Related Peptide; D002799:Cholinergic Fibers / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D005528:Foot; D005728:Ganglia, Sympathetic / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051381:Rats; D013545:Sweat Glands / Q000294:innervation*; D013564:Sympathetic Nervous System / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D014660:Vasoactive Intestinal Peptide; D015740:Calcitonin Gene-Related Peptide