[Effect of immunization with K1-antigen of Escherichia coli on the course of experimental urinary tract infection in the rat].
The influence of the vaccination with an immunogenic K1-antigen of Escherichia coli on the course of an experimental pyelonephritis in rats due to Escherichia coli O2:K1:H3 was investigated. K1-antigen is a poor immunogen. Therefore a conjugate of K1-antigen with bovine serum albumin (BSA) was used. This K1-BSA-conjugate was immunogenic in preliminary experiments. The influence of a vaccination on the course of pyelonephritis may be dependent on the route of infection. Rats which are infected by a retrograde route shows significant less inflammated kidneys when they received a vaccination by K1-BSA-conjugate within the first six weeks of infection.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis*; D000942:Antigens, Bacterial; D000954:Antigens, Surface / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D001437:Bacteriuria / Q000276:immunology; D003520:Cyclophosphamide / Q000494:pharmacology; D004926:Escherichia coli / Q000276:immunology; D004927:Escherichia coli Infections / Q000276:immunology*; D005260:Female; D011702:Pyelitis / Q000276:immunology; D011704:Pyelonephritis / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D012710:Serum Albumin, Bovine / Q000276:immunology; D014552:Urinary Tract Infections / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001428:Bacterial Vaccines; C030659:K antigens; D012710:Serum Albumin, Bovine; D003520:Cyclophosphamide
Einfluss einer Immunisierung mit K1-antigen von Escherichia coli auf den Verlauf der experimentellen Harnweginfektion bei der Ratte.