Effect of PGE2 on regional cortico-endosteal remodeling in beagles with fractured ribs: a histomorphometric study.
A histomorphometric study was done on healing defects in the ribs of Beagles. A transverse fracture was made in the left 9th and 10th ribs. Beagles were given either ethanol vehicle (n = 6) or prostaglandin E2 (PGE2) orally (n = 5) for the 30-day period after surgical manipulation to time of necropsy. Double fluorescent labels were given to measure bone matrix mineralization. Two fluorochrome markers were used: calcein before dogs were surgically manipulated and oxytetracycline HCl before they were killed. The two objectives of the present study were: (1) to determine the effects of fracture on regional cortico-endosteal remodeling 2 cm from a fracture site in the ribs of Beagles; and (2) to determine the effects of orally administered PGE2 on the above condition. The results suggested that the fractured and the non-fractured ribs in either group show a similar static and dynamic remodeling during the first 30 days of healing. The activation frequency in the PGE2 group was increased in both fractured and non-fractured ribs more than in the non-treated group. Therefore, the systemic administration of PGE2 can activate and synchronize remodeling cycles among BMUs.
D000818:Animals; D015232:Dinoprostone / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D005452:Fluoresceins; D007202:Indicators and Reagents; D008297:Male; D012253:Rib Fractures / Q000188:drug therapy* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
D005452:Fluoresceins; D007202:Indicators and Reagents; D015232:Dinoprostone; C007740:fluorexon