title: Induction of seizures by air blast in gerbils: stimulus duration/effect relationship.
abstract: In air blast-induced seizures in gerbils, there is a relationship between the duration of the air blast and the incidence of 'major' convulsions. An ET50 of 9.6 sec was determined in untreated controls; pretreatment with anticonvulsant drugs shifted the stimulus/effect curve to the right. This 'stimulus summation' phenomenon makes a clearly defined challenge necessary when drug effects are to be evaluated.
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use; D004195:Disease Models, Animal; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology*; D005849:Gerbillinae / Q000502:physiology*
chemical_list: D000927:Anticonvulsants