Current ideas on the pathophysiology and treatment of lantana poisoning of ruminants.
Lantana poisoning in ruminants results from the ingestion of toxic varieties of the plant Lantana camara, which contain the triterpene acids lantadene A and lantadene B. Poisoning results in intrahepatic cholestasis and the consequences of the liver injury include jaundice, photosensitisation and ruminal stasis. The decreased ruminal motility causes toxic material to be retained in the rumen and continuous absorption of toxins from the rumen maintains the disease. Lantana poisoning can best be treated by preventing further absorption of toxins. This can be achieved by giving a large quantity of activated charcoal into the rumen together with a large volume of a multiple electrolyte solution to stimulate ruminal motility and rehydrate the animal. Treatment for photosensitive dermatitis should also be given.
D000818:Animals; D002417:Cattle; D006041:Goats; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000506:poisoning; D010939:Plant Poisoning / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*; D012418:Ruminants; D012756:Sheep; D014315:Triterpenes / Q000506:poisoning
D014315:Triterpenes; C017004:22 beta-angeloyloxy-oleanolic acid; D009828:Oleanolic Acid; C019074:rehmannic acid