[Anaerobic shift of energy metabolism in the mouse brain during the recovery period in acute radiation sickness].
Three months after whole-body irradiation of mice with a sublethal dose of 5 Gy a study was made of some indices of energy metabolism like tissue respiration, oxidative phosphorylation, and formation of lactic acid in the survived brain homogenate. Revealed were the diminution of coupling of tissue respiration of oxidative phosphorylation, the rate of oxygen consumption and the level of cyano-resistant respiration being constant, the increase in the rate of glycolysis in anaerobic and particularly, in aerobic conditions, and reduction of the Pasteur and Crabtree effects. The above mentioned changes in the brain energy metabolism seem to be a manifestation of the process of the reduced metabolism formation in the nervous tissue at the remote times after irradiation.
D000208:Acute Disease; D000693:Anaerobiosis / Q000528:radiation effects; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000528:radiation effects; D004734:Energy Metabolism / Q000528:radiation effects*; D007773:Lactates / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010085:Oxidative Phosphorylation / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D013997:Time Factors; D014916:Whole-Body Irradiation
D007773:Lactates
Anaérobnyĭ sdvig énergeticheskogo obmena v golovnom mozge mysheĭ v vosstanovitel'nom periode ostroĭ luchevoĭ bolezni.