[Effect of different glucocorticoids on the in vitro cell kinetics of human hematopoiesis represented by a bone marrow culture and by phytohemagglutinin- and pokeweed mitogen-stimulated blood cultures].
The effect of nine glucocorticoids, DHEA, cyclohexanol and dextran sulphate on the hematopoietic proliferation was investigated. Three glucocorticoids inhibited the proliferation of normal bone marrow cells, the others enhanced it. The T-cell stimulation was not inhibited by fluorcortolone contrary to prednisolone. Specially the proliferation of acute myeloid leukemic blasts was inhibited by fluorcortolone hemisulfate, which significantly stimulated the proliferation of normal bone cells.
D001773:Blood Cells / Q000187:drug effects*; D001853:Bone Marrow / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005938:Glucocorticoids / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000097:blood; D015470:Leukemia, Myeloid, Acute / Q000097:blood; D010835:Phytohemagglutinins / Q000494:pharmacology*; D011043:Pokeweed Mitogens / Q000494:pharmacology*; D013268:Stimulation, Chemical
D005938:Glucocorticoids; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens
Die Wirkung verschiedener Glukokortikoide auf die Zellkinetik der menschlichen Hämatopoese in vitro, dargestellt an der Knochenmarkkultur und an der mit Phytohämagglutinin und Pokeweed Mitogen stimulierten Blutkultur.