title: Comparison of the in vitro cytotoxicities and acute in vivo toxicities of 59 chemicals.
abstract: The in vitro cytotoxicities of 59 chemicals, expressed as ID50 values (i.e., concentrations of test chemicals that reduced the final cellular protein content of test cultures by 50% in comparison with appropriate solvent control cultures) and obtained using murine 3T3-L1 cells and the FRAME kenacid blue method, have been compared with rat oral and mouse intraperitoneal (ip) LD50 values. A better in vivo/in vitro correlation was obtained for the 59 chemicals with mouse ip LD50 values (r = .80) than with rat oral LD50 values (r = .76), but the best in vivo/in vitro correlation was found when the most toxic of the rat and mouse values were used in the comparison (r = .81).
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002470:Cell Survival / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D051379:Mice; D051381:Rats; D014116:Toxicology / Q000379:methods*