[Immunocytochemistry of steroid hormone receptors. New aspects of cellular and endocrine physiology].
Recent immunohistochemical data challenge the concept of nuclear translocation of steroid hormone-receptor complexes proposed initially by Jensen et al. and Gorski et al. The detection of estrogen and progesterone receptors exclusively in the nucleus of target cells is at variance with the presence of the free receptor in the cytoplasm. In this review, we discuss how our concept of the mechanism of action of steroid hormone ought to be revised in the light of the new data.
D000818:Animals; D000906:Antibodies / Q000276:immunology; D000918:Antibody Specificity; D002467:Cell Nucleus / Q000378:metabolism; D002468:Cell Physiological Phenomena; D002843:Chromatin / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005260:Female; D006651:Histocytochemistry; D007158:Immunologic Techniques; D008297:Male; D008954:Models, Biological; D011960:Receptors, Estrogen / Q000276:immunology / Q000502:physiology; D011980:Receptors, Progesterone / Q000276:immunology / Q000502:physiology; D011987:Receptors, Steroid / Q000502:physiology*; D014018:Tissue Distribution
D000906:Antibodies; D002843:Chromatin; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid; D004247:DNA
Immunocytochimie des récepteurs des hormones stéroïdes. Aspects nouveaux de physiologie cellulaire et endocrinienne.