An ovulation inducing agent containing clomiphene citrate causes DNA-strand breaks without SOS responses in Escherichia coli.
Effects of Clomid, an ovulation-inducing drug containing clomiphene citrate, on Escherichia coli were investigated. Radiation-sensitive mutants, uvrA and recA, were more sensitive to Clomid than the parental wild-type strain. DNA synthesis in these two strains was more depressed by Clomid than that in the wild-type strain. Clomid caused DNA-strand breaks, but few SOS responses such as mutation, induction of prophage and expression of the umuC+ gene were induced.
D002996:Clomiphene / Q000009:adverse effects*; D004260:DNA Repair / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D010060:Ovulation / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects
D004269:DNA, Bacterial; D002996:Clomiphene