title: Digoxin--issues and controversies.
abstract: This review deals briefly with the clinical pharmacology of digoxin and reviews in some depth the problems inherent in methods of digoxin measurement. Digoxin-like factors (materials that cross react in digoxin immunoassays) are discussed, and some current evidence suggesting the existence of a new hormone, endoxin (endogenous digoxin), is summarized.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000918:Antibody Specificity; D001682:Biological Availability; D001798:Blood Proteins / Q000032:analysis; D002298:Cardenolides; D004077:Digoxin / Q000276:immunology / Q000378:metabolism* / Q000506:poisoning / Q000627:therapeutic use; D005189:False Positive Reactions; D006801:Humans; D007118:Immunoassay; D007140:Immunoglobulin Fab Fragments; D007275:Injections, Intravenous; D007700:Kinetics; D008657:Metabolic Clearance Rate; D012503:Saponins; D014018:Tissue Distribution
chemical_list: D001798:Blood Proteins; D002298:Cardenolides; D007140:Immunoglobulin Fab Fragments; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin