Homogeneous interferon-beta-inducing 25K factor (IL-1 beta) has connective tissue cell stimulating activities.
The human interferon-beta-inducing 22K factor has been shown to have structural homologies with interleukin-1 beta (IL-1 beta) and some of the activities attributed to IL-1. We have shown that 22K factor, purified to homogeneity and endotoxin free, has connective tissue cell stimulating activities, indicating that these activities are due to a naturally occurring species of IL-1 beta and not contaminating factors. 22K factor stimulated the production of prostaglandin E, caseinase activity and plasminogen activator activity in human articular chondrocytes in culture. This cell system appears highly sensitive to 22K factor activity. 22K factor also stimulated the resorption of bovine nasal cartilage and neonatal mouse calvaria.
D000818:Animals; D001681:Biological Assay; D001862:Bone Resorption / Q000187:drug effects; D002358:Cartilage, Articular / Q000187:drug effects / Q000378:metabolism; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D003239:Connective Tissue Cells; D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D008666:Metalloendopeptidases; D008970:Molecular Weight; D010447:Peptide Hydrolases / Q000378:metabolism; D010960:Plasminogen Activators / Q000378:metabolism; D011458:Prostaglandins E / Q000096:biosynthesis
D007375:Interleukin-1; D011458:Prostaglandins E; D010450:Endopeptidases; D010447:Peptide Hydrolases; C022474:proteoglycan-degrading metalloendopeptidases; D010960:Plasminogen Activators; D008666:Metalloendopeptidases; C030895:caseinase