Reduction of cephamycin concentrations at the infection site in mice with experimental peritoneal infection caused by cephalosporinase-producing bacteria.
In an experimental model of peritoneal infection by cephalosporinase- (Ia and Ic) producing bacteria in mice, the reduction of cefoxitin, cefmetazole, and cefazolin concentrations in peritoneal fluid was observed in the mice infected with the Ia enzyme producer, whereas cefbuperazone concentrations were not reduced.
D000818:Animals; D001202:Ascitic Fluid / Q000378:metabolism*; D002437:Cefazolin / Q000378:metabolism; D015311:Cefmetazole; D002440:Cefoxitin / Q000378:metabolism; D002510:Cephalosporinase / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism*; D002513:Cephamycins / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004754:Enterobacter / Q000201:enzymology; D004756:Enterobacteriaceae Infections / Q000378:metabolism / Q000382:microbiology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010538:Peritonitis / Q000378:metabolism / Q000382:microbiology; D011512:Proteus Infections / Q000378:metabolism / Q000382:microbiology*; D011514:Proteus vulgaris / Q000201:enzymology; D001618:beta-Lactamases / Q000378:metabolism*
D002511:Cephalosporins; D002513:Cephamycins; D015311:Cefmetazole; D002440:Cefoxitin; D002510:Cephalosporinase; D001618:beta-Lactamases; D002437:Cefazolin; C035978:cefbuperazone