Beneficial effects of sodium salt of 17(R)-methyl-20-isopropylidenecarbacyclin on experimentally-induced ischemic hind limb lesions and blood viscosity.
The occlusion of the femoral artery of rats induced reproducible hind limb lesions resembling thromboangiitis and obliterative arteriosclerosis. 17(R)-Methyl-20-isopropylidenecarbacyclin (CS-570), as well as alprostadil (PGE1), ticlopidine and pentoxifylline, inhibited the lesions. The occlusion of the femoral artery of rabbits caused elevation of the viscosity of the returning venous blood and echinocytic shape changes of erythrocytes. CS-570, as well as PGE1, also inhibited these changes. The decreased deformability of erythrocytes of rats under acidic conditions was improved by CS-570 and PGE1. The usefulness of CS-570 for the treatment of periferal arterial diseases was suggested.
D000818:Animals; D011464:Epoprostenol / Q000627:therapeutic use* / Q000031:analogs & derivatives; D004907:Erythrocyte Deformability / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006400:Hematocrit; D006614:Hindlimb / Q000098:blood supply*; D066298:In Vitro Techniques; D007511:Ischemia / Q000188:drug therapy*; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects
D005343:Fibrinolytic Agents; C038991:R 59274; D011464:Epoprostenol