Immunoelectron microscopic investigation of HLA-DR-positive dendritic cells at the dermo-epidermal junction in skin disorders associated with the deposition of immune complexes.
HLA-DR-positive dendritic cells present at the dermo-epidermal junction in skin disorders associated with the deposition of immunoglobulins and/or complement factors in the skin biopsy are investigated ultrastructurally. They demonstrate long, slender cytoplasmic processes, an indented nucleus, and strikingly dilated cisternae of the endoplasmic reticulum. HLA-DR antigen is present on the plasma membrane and within some of the dilated cisternae. These findings further support our previously formulated hypothesis that these cells represent a functionally active stage of antigen-presenting cells.
D000936:Antigen-Antibody Complex; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007158:Immunologic Techniques; D007801:Langerhans Cells / Q000276:immunology / Q000648:ultrastructure; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D012867:Skin / Q000276:immunology* / Q000648:ultrastructure; D012871:Skin Diseases / Q000276:immunology*
D000936:Antigen-Antibody Complex; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II