Selective mutagenic activity of 2-bromo-propanamides on Salmonella typhimurium. A structure-activity study.
Nineteen 2-halogeno-acetamides, -propanamides, and -iso-butyramides and four related epoxyamides were tested as mutagens for Salmonella typhimurium TA100. Mutagenic activity was observed in strictly selected 2-halogenoamides and in all epoxyamides. The effectiveness of 2-halogenoamides depends upon: the character of the carbon carrying the halogen (1 degree, 2 degrees, 3 degrees); the nature of the halogen (Br, Cl); the substitution at nitrogen. Some considerations concerning the selectivity observed are presented.
D000477:Alkylating Agents; D000577:Amides / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D001966:Bromine / Q000633:toxicity; D004852:Epoxy Compounds; D009682:Magnetic Resonance Spectroscopy; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D011422:Propionates / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000477:Alkylating Agents; D000577:Amides; D004852:Epoxy Compounds; D009153:Mutagens; D011422:Propionates; D001966:Bromine