A single blind randomized endoscopic study comparing the effects of diflunisal and naproxen in patients with osteoarthritis.
A single blind randomized endoscopic study comparing the effects of diflunisal and naproxen on the gastric and duodenal mucosa of 34 patients with osteoarthritis was performed over a 2-week period. At the dosages utilized in the study, diflunisal produced significantly less gastric injury than naproxen, as assessed by mean gastric injury scores (p = 0.0002). Sixty-five percent of the diflunisal treated group had no evidence of gastric mucosal injury compared with 13% in the naproxen group. Moreover, treatment with diflunisal resulted in a significantly lower incidence of severe gastric injury than naproxen (p less than 0.01).
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D004061:Diflunisal / Q000009:adverse effects*; D004064:Digestive System / Q000187:drug effects*; D004361:Drug Tolerance; D004724:Endoscopy; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects; D008875:Middle Aged; D009288:Naproxen / Q000009:adverse effects*; D010003:Osteoarthritis / Q000188:drug therapy*; D011897:Random Allocation; D012459:Salicylates / Q000009:adverse effects*
D012459:Salicylates; D009288:Naproxen; D004061:Diflunisal