Some parameters of conditioned immunosuppression: species difference and CS-US delay.
Three experiments were conducted in which an illness-inducing immunosuppressant, cyclophosphamide (an unconditioned stimulus, US) was associated with a previously presented saccharin solution conditioned stimulus (CS). In each experiment, reexposure to the CS produced a conditioned suppression of the plaque-forming-cell response in the experimental groups. Experiment I demonstrated this result with Fisher 344 rats. Experiment II replicated the effect with Balb/c mice. In Experiment III conditioned immunosuppression was demonstrated when mice received CS-US delays as long as 6 hours. No evidence of a delay gradient was present in either the behavioral or the immunologic data. These parallel findings offer no support for the idea of a dissociation between the taste aversion and conditioned immunosuppression processes.
D000704:Analysis of Variance; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D004327:Drinking Behavior; D005260:Female; D006462:Hemolytic Plaque Technique; D007165:Immunosuppression Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D011916:Rats, Inbred F344; D012439:Saccharin / Q000494:pharmacology*; D013045:Species Specificity
D003520:Cyclophosphamide; D012439:Saccharin