title: [Methodological approaches to evaluating the sensitizing properties of new drug preparations in preclinical trials].
abstract: For testing allergenic activity of 18 drugs with various pharmacological properties the reaction of specific leukocyte agglomeration, specific leukocyte lysis reaction, determination of Mg2+ blood serum content and epicutaneous drug application were used. An attempt was made to establish the relationship between the development of immunological response and the time and duration of allergization, the dosage and routes of allergen administration and also to determine the optimal experimental conditions for appearance of the most pronounced response.
mesh_terms: D000485:Allergens / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004342:Drug Hypersensitivity / Q000276:immunology; D006168:Guinea Pigs; D007158:Immunologic Techniques; D013997:Time Factors
chemical_list: D000485:Allergens
vernacular_title: Metodicheskie podkhody k otsenke sensibiliziruiushchikh svoĭstv novykh lekarstvennykh preparatov na stadii doklinicheskogo ispytaniia.