Cell surface markers of acute non-lymphocytic leukemias: leukemia type and its expression of C3 and Fc receptors.
Seventeen untreated human acute non-lymphocytic leukemias (ANLL) were classified into four groups according to the presence or the absence of complement receptor and Fc receptor for IgG and IgM: Group I having neither C3 nor Fc receptors, Group II having either C3 or Fc receptor and Group III having both C3 and Fc receptors. ANLL of Group II was further subdivided into two groups: Group IIa having only Fc receptor and Group IIb having only C3 receptor. The morphologic and cytochemical analysis of ANLL in these groups revealed that the most immature type with regard to their myeloid-monocyte lineage was Group IIb followed by Groups I, IIa and III. Two cases of Group IIb were regarded as M1 type by French-American-British (FAB) group classification and one of them had a Ph1-chromosome. The survival rate of patients in each group was investigated and Group IIb patients showed the tendency for the longest period of survival.
D000208:Acute Disease; D002454:Cell Differentiation; D002462:Cell Membrane / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007938:Leukemia / Q000145:classification / Q000276:immunology* / Q000401:mortality; D007951:Leukemia, Myeloid / Q000276:immunology; D016177:Macrophage-1 Antigen; D011951:Receptors, Complement / Q000032:analysis*; D011961:Receptors, Fc / Q000032:analysis*
D016177:Macrophage-1 Antigen; D011951:Receptors, Complement; D011961:Receptors, Fc