The effect of aminophylline on renin release from human chorio-decidua.
The effect of aminophylline on renin release from human chorion was investigated by perfusing the tissue with various concentrations of the drug. Buffer containing aminophylline (2 X 10(-6) mol/l) doubled the rate of active and total renin secretion, but a more concentrated solution (10(-5) mol/l) released proportionately less active and total renin although the result was statistically significant. Renin secretion was not altered by aminophylline (5 X 10(-5) mol/l). The pattern of renin release was modulated by concentrations of aminophylline which were at least a 100-fold lower than those required to inhibit cyclic adenosine 3',5'-monophosphate phosphodiesterase. However, as the methylxanthines are potent adenosine receptor antagonists, we suggest that in the human chorion adenosine is a mediator of renin release.
D000628:Aminophylline / Q000494:pharmacology*; D002823:Chorion / Q000201:enzymology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D011247:Pregnancy; D012083:Renin / Q000378:metabolism*
D000628:Aminophylline; D012083:Renin