Methacholine inhalation challenge after rapid saline infusion in healthy subjects.
Five healthy subjects were challenged with methacholine on 2 different days, 1 week apart, the second day after acute intravenous 30 ml/kg 0.9% saline infusion. After infusion, we observed a significant reduction in vital capacity (VC), maximal expiratory volume in 1 s (FEV1), provocation dose producing a 35% fall in SGaw (PD35SGaw) and in 25% of maximal expiratory flow (MEF25), and an increase in the slopes of log dose-response curves. Our results suggest an increased bronchial reactivity in acute minimal interstitial lung edema.
D000328:Adult; D000336:Aerosols; D000403:Airway Resistance / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects / Q000502:physiology; D001985:Bronchial Provocation Tests; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000008:administration & dosage; D011654:Pulmonary Edema / Q000175:diagnosis* / Q000503:physiopathology; D012129:Respiratory Function Tests; D012965:Sodium Chloride / Q000008:administration & dosage
D000336:Aerosols; D008688:Methacholine Compounds; D016210:Methacholine Chloride; D012965:Sodium Chloride