Effect of indomethacin on glucose absorption and insulin release in patients with impaired glucose tolerance.
Determinations of the levels of blood glucose and of serum insulin-like activity were made in 12 patients with impaired glucose absorption treated with indomethacin 4 x 25 mg for a day. By comparing the results with untreated control patients, it was found that the peak blood level of glucose, and the serum level of insulin-like activity, could be significantly decreased by this oral administration of indomethacin. The decrease of blood level of glucose appeared 0.5 h before the decrease of insulin-like activity in these patients with impaired glucose tolerance.
D000284:Administration, Oral; D001786:Blood Glucose / Q000032:analysis; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D007328:Insulin / Q000097:blood*; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D005947:Glucose; D007213:Indomethacin