[Inhibition of natural killer and interleukin 2-activated natural killer cell cytotoxicity by monosaccharides and lectins].
NK cell receptors may be saturated and inhibited by a serial monosaccharides and lectins. Subsequently, NK cytotoxicity diminished in different ratios. Phosphorylated mannose and galactose were the major inhibitors. Also, the most of the lectins have NK cell inhibitory capacity. Normal lymphocyte may be activated by IL-2 within 72 hours culture. Those activated lymphocytes exerts high cytotoxicity and wide recognition capacity for the tumor targets. Besides, their receptors are less sensitive for the sugar inhibition. Lectins, have strong inhibition capacity even the lymphocytes are activated by IL-2.
D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D005690:Galactose / Q000494:pharmacology; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology*; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D037102:Lectins / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008358:Mannose / Q000494:pharmacology; D009005:Monosaccharides / Q000494:pharmacology*
D007376:Interleukin-2; D037102:Lectins; D009005:Monosaccharides; D008358:Mannose; D005690:Galactose
Natural killer (doğal öldürücü) ve interleukin-2 ile uyarilmiş natural killer hücre sitotoksisitelerinin monosakkaritler ve lektinlerle önlenmesi.