Duration of morning stiffness in rheumatic patients after medication with enteric-coated and plain naproxen tablets.
Twenty-nine adult rheumatic patients who were taking 500 mg naproxen at bedtime and had a certain degree of morning stiffness despite this medication took part in a randomized double-blind cross-over study in which the duration of morning stiffness after evening doses of 500 mg enteric-coated naproxen tablets was compared with that after identical doses of plain naproxen tablets. The duration of morning stiffness was significantly shorter after taking enteric-coated tablets (p less than 0.01), and the mean plasma naproxen morning concentration was 34% higher (p = 0.01). Since the results were unambiguous in such a small group of patients, they are judged to be of considerable clinical value.
D000328:Adult; D000368:Aged; D016918:Arthritis, Reactive / Q000503:physiopathology; D001172:Arthritis, Rheumatoid / Q000503:physiopathology*; D002940:Circadian Rhythm; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004548:Elasticity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000008:administration & dosage* / Q000097:blood; D010349:Patient Compliance; D011897:Random Allocation; D013607:Tablets; D013608:Tablets, Enteric-Coated; D013995:Time; D013997:Time Factors
D013607:Tablets; D013608:Tablets, Enteric-Coated; D009288:Naproxen