title: [Treatment of acute symptoms of hemorrhoid disease with high-dose oral O-(beta-hydroxyethyl)-rutosides].
abstract: The pharmacological treatment is widely used in the therapy of haemorrhoids. An efficient treatment is particularly useful in case of haemorrhoids of 2nd, 3rd and 4th degree, when phlogosis, oedema and pain are present. Forty patients were treated with either O-(beta-hydroxyethyl)-rutosides (4 g/day orally) or placebo in a double blind randomized comparative trial. The groups of treatment were homogeneous. O-(beta-hydroxyethyl)-rutosides induced a statistically significant reduction of pain and bleeding; placebo did not induce any significant improvement. Tolerability was good and similar for both treatments. It has never been necessary to stop treatment for side effects. The results obtained in this study confirm the usefulness on administering an oral treatment, and not only a local treatment, to patients with acute symptoms of haemorrhoids, both in case of intermittent treatment and in case it is used to prepare quickly the patient for surgery.
mesh_terms: D000284:Administration, Oral; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006484:Hemorrhoids / Q000188:drug therapy*; D006801:Humans; D006896:Hydroxyethylrutoside / Q000008:administration & dosage*; D008297:Male; D011897:Random Allocation; D012431:Rutin / Q000031:analogs & derivatives*
chemical_list: D006896:Hydroxyethylrutoside; D012431:Rutin
vernacular_title: Trattamento dei sintomi acuti della malattia emorroidaria con O-(beta-idrossietil)-rutosidea ad alte dosi per via orale.