title: [Effects of horse-chestnut seed extract on transcapillary filtration in chronic venous insufficiency].
abstract: The effect of horse-chestnut seed extract (standardized on aescin; Venostasin retard) was assessed in a randomized placebo-controlled crossover double-blind trial of 22 patients with proven chronic venous insufficiency by measuring the capillary filtration coefficient and the intravascular volume of the lower leg by venous-occlusion plethysmography. Three hours after taking two capsules of Venostasin (600 mg; each capsule containing 50 mg aescin) the capillary filtration coefficient had decreased by 22%, whereas after administration of an identical-looking placebo capsule it rose but slightly over three hours. The difference in the effect of Venostasin and placebo is statistically significant (P = 0.006). The intravascular volume was reduced 5% more after Venostasin than the placebo, but this is not statistically significant. It is concluded that Venostasin has an inhibitory effect on oedema formation via a decrease in transcapillary filtration and thus improves oedema-related symptoms in venous diseases of the legs.
mesh_terms: D002199:Capillary Permeability / Q000187:drug effects; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations / Q000494:pharmacology / Q000627:therapeutic use; D004928:Escin / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D012503:Saponins / Q000627:therapeutic use*; D014689:Venous Insufficiency / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D004338:Drug Combinations; D010936:Plant Extracts; D012503:Saponins; C039661:venostasin; D004928:Escin
vernacular_title: Wirkung von Rosskastaniensamenextrakt auf die transkapilläre Filtration bei chronischer venöser Insuffizienz.