Evaluation of pefloxacin in experimental Escherichia coli meningitis.
The therapeutic efficacy of the fluoroquinolone pefloxacin mesylate was compared with those of cefotaxime and chloramphenicol in a rabbit model of Escherichia coli meningitis. The mean percent penetration (+/- the standard deviation) of pefloxacin (range, 1 to 30 mg/kg per h) into cerebrospinal fluid of infected rabbits was 51.3 +/- 14.0 compared with 11.1 +/- 1.0 for cefotaxime (100 mg/kg per h) and 22.3 +/- 1.5 for chloramphenicol (60 mg/kg per h). The rate of bacterial killing (delta log10 CFU/ml per h) did not change over a dosage range of 1 to 15 mg/kg per h (-0.37 +/- 0.15, 20% sterile). At 30 mg/kg per h, the rate achieved (-0.77 +/- 0.18, 100% sterile) was comparable to that of cefotaxime (-0.88 +/- 0.23, 100% sterile) and superior to that of chloramphenicol (-0.10 +/- 0.14, 0% sterile).
D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism / Q000627:therapeutic use*; D002439:Cefotaxime / Q000627:therapeutic use; D002701:Chloramphenicol / Q000627:therapeutic use; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008581:Meningitis / Q000188:drug therapy* / Q000209:etiology; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D015366:Pefloxacin; D011817:Rabbits; D013997:Time Factors
D000890:Anti-Infective Agents; D015366:Pefloxacin; D002701:Chloramphenicol; D009643:Norfloxacin; D002439:Cefotaxime