title: Synthesis and biological activity of isodithiobiurets, dithiobiurets, and dithiazoles.
abstract: A series of isodithiobiurets, dithiobiurets, and dithiazoles was synthesized and tested for biological activity. Generally, the compounds potentiated the hypnosis induced by pentobarbitone (50 mg/kg ip) in albino mice and exhibited antifungal and insecticidal activity against Fusarium oxysporum and Periplanata americana, respectively. Some compounds showed anticonvulsant and analgesic activity in albino rats.
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis*; D001737:Biuret / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D005670:Fusarium / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis; D007306:Insecticides / Q000494:pharmacology; D008297:Male; D051379:Mice; D010526:Periplaneta / Q000187:drug effects; D051381:Rats; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014508:Urea / Q000031:analogs & derivatives
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D000935:Antifungal Agents; D006993:Hypnotics and Sedatives; D007306:Insecticides; D013844:Thiazoles; D001737:Biuret; D014508:Urea