The 20,000 dalton structural variant of recombinant DNA-derived methionyl human growth hormone has early insulin-like effects in hypophysectomized rats.
The 20,000 dalton variant of recombinant DNA-derived methionyl human growth hormone (20K-Met-hGH) induced decreases in blood glucose and free fatty acid concentrations one hour after intraperitoneal injection into fasted, hypophysectomized rats. Similar results were obtained using the 22,000 dalton form of recombinant DNA-derived methionyl human growth hormone (22K-Met-hGH). The data reported show that 20K-Met-hGH induces early insulin-like effects similar to the responses produced by 22K-Met-hGH in fasted hypophysectomized rats.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004274:DNA, Recombinant / Q000032:analysis*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000031:analogs & derivatives* / Q000235:genetics / Q000494:pharmacology; D019382:Human Growth Hormone; D007016:Hypophysectomy; D007328:Insulin / Q000494:pharmacology*; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000235:genetics* / Q000494:pharmacology; D013997:Time Factors
D001786:Blood Glucose; D004274:DNA, Recombinant; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D011994:Recombinant Proteins; D019382:Human Growth Hormone; D013006:Growth Hormone