Activation and inhibition of yeast aldehyde dehydrogenase activity by pantethine and its metabolites.
D-Pantethine-related metabolites, such as taurine, D-pantetheine, coenzyme A and D-pantothenate, activated yeast aldehyde dehydrogenase in vitro. D-Pantethine and cysteamine hydrochloride, however, strongly inhibited the activity of this enzyme.
D000105:Acetyl Coenzyme A / Q000494:pharmacology; D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003065:Coenzyme A / Q000494:pharmacology; D003543:Cysteamine / Q000494:pharmacology; D004789:Enzyme Activation; D010204:Pantetheine / Q000031:analogs & derivatives / Q000494:pharmacology*; D010205:Pantothenic Acid / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013654:Taurine / Q000494:pharmacology
D013438:Sulfhydryl Compounds; D010205:Pantothenic Acid; D013654:Taurine; D010204:Pantetheine; D003543:Cysteamine; D000105:Acetyl Coenzyme A; C005425:pantethine; D000444:Aldehyde Dehydrogenase; D003065:Coenzyme A