title: Dose-proportional absorption of etretinate after doses of 25, 50, 75, and 100 mg.
abstract: Twelve healthy male subjects received single oral doses of etretinate, ranging from 25 to 100 mg (1 to 4 x 25-mg capsules) in an open-label, four-way randomized crossover design. Plasma concentrations of etretinate and two active metabolites were determined by a specific high-performance liquid chromatographic (HPLC) method. Analysis of variance and orthogonal contrasts were used to assess dose proportionality. Mean (+/- %CV) maximum concentrations after 25- to 100-mg doses were 133 (50), 195 (33), 261 (53), and 446 (65) ng/ml, whereas AUC0-12 values were 581 (46), 1090 (39), 1500 (52), and 2440 (63) ng.hr/ml, respectively. The test for proportionality indicated that Cmax and AUC0-12 increased proportionally with an increase in dose (P greater than 0.05).
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D005050:Etretinate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male
chemical_list: D005050:Etretinate