A radiosensitive T-lymphocyte associated with resistance of DBA/2 mice harboring Friend leukemia virus-dormant infections to transplantable Friend leukemia virus-erythroleukemia cells.
The immunobiology of Friend erythroleukemia virus (FLV) has been the focal point of much research into immunological control of leukemia. We have been studying a murine model in which a rapidly fatal FLV infection of DBA/2 mice is suppressed to a dormant state by treatment with statolon, a double stranded RNA extract of Mycoplasma stoloniferum. We report here that mice with FLV-dormant infections resist the accumulation of transplanted FLV-transformed erythroleukemia cells (FLC-745) and that FLC-745 cells persist in the spleen for a prolonged period. Winn assays revealed that the spleen of FLV-dormant mice contain radiosensitive T-lymphocytes with anti-FLC-745 cell activity. Whole body irradiation of FLV-dormant mice abrogated their resistance to transplanted FLC-745 cells and confirmed the radiosensitivity of the protective immune response.
D000818:Animals; D002460:Cell Line; D002472:Cell Transformation, Viral; D005260:Female; D005622:Friend murine leukemia virus; D007111:Immunity, Cellular / Q000528:radiation effects; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D013154:Spleen / Q000382:microbiology; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D014018:Tissue Distribution; D014916:Whole-Body Irradiation