Treatment of LD100 Escherichia coli septic shock with netilmicin and methylprednisolone in baboons.
Treatment efficacy with netilmicin sulphate/methylprednisolone sodium succinate in a severe septic shock baboon model, using an LD100 of live Escherichia coli, was evaluated. All the animals treated with both netilmicin and methylprednisolone were permanent (greater than or equal to 7 days) survivors, whereas none of the untreated baboons lived more than 24 hours. These results indicate that, in a baboon model, netilmicin is an effective alternative to gentamicin (with methylprednisolone) in the treatment of severe septic shock.
D000818:Animals; D004359:Drug Therapy, Combination; D004927:Escherichia coli Infections / Q000188:drug therapy*; D005260:Female; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D009428:Netilmicin / Q000627:therapeutic use*; D010215:Papio; D012772:Shock, Septic / Q000188:drug therapy*
D009428:Netilmicin; D008775:Methylprednisolone