Prostaglandin derivative PGBx improves neurologic recovery after ischemic spinal injury.
Neurological dysfunction resulting from an ischemic insult in the central nervous system (CNS) is believed to be an indirect outcome of impaired energy production. Recent studies suggest that prostaglandin Bx (PGBx), an oligomer of PGB1 and 15-keto-PGB1, may be beneficial in protecting mitochondrial function after ischemic insults by preventing uncoupling of oxidative phosphorylation. In the present study, PGBx had a significant influence on neurological outcome after ischemic injury in the rabbit spinal cord. These findings suggest that PGBx may be beneficial in the treatment of CNS ischemic injuries.
D000818:Animals; D004734:Energy Metabolism; D006614:Hindlimb / Q000294:innervation*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects; D010086:Oxidative Phosphorylation Coupling Factors / Q000378:metabolism; D011108:Polymers / Q000627:therapeutic use*; D011453:Prostaglandins / Q000627:therapeutic use*; D011456:Prostaglandins B / Q000627:therapeutic use*; D011817:Rabbits; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000503:physiopathology
D010086:Oxidative Phosphorylation Coupling Factors; D011108:Polymers; D011453:Prostaglandins; D011456:Prostaglandins B; C024303:prostaglandin Bx