Current approaches to measurement of insulin secretion.
The studies reviewed in this article have indicated that C-peptide and insulin are cosecreted from the beta cell in equimolar concentration, that C-peptide does not undergo significant hepatic extraction, and that its MCR remains constant over the physiologic range of concentrations. Furthermore, the peripheral kinetics of distribution of C-peptide can be described by a two-compartment mathematical model. If model parameters are derived in individual subjects by analysis of C-peptide decay curves, this information can subsequently be used to derive insulin secretion rates with a great degree of accuracy from endogenously secreted C-peptide concentrations. The application of this approach to clinical research studies should greatly enhance our understanding of insulin secretion.
D000818:Animals; D002096:C-Peptide / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D012636:Secretory Rate
D002096:C-Peptide; D007328:Insulin