Alcohol and dilated cardiomyopathy.
Alcohol has been considered a cardiotoxin for over a century, but the pathogenesis and natural history of alcohol-related heart disease remains obscure. The diagnosis still rests on the coincidence of alcoholism and a dilated hypocontractile heart in the absence of any other cause of dilated cardiomyopathy. Advances have been made in our understanding of the effects of acute and chronic alcohol administration both at a haemodynamic and cellular level, and recent studies have indicated that preclinical changes in LV dimensions and function are common in alcoholics. It is not known whether clinical cardiomyopathy, which develops in only 1-2% of heavy drinkers, occurs because of genetic predisposition, or the presence of synergistic cardiovascular risk factors. Abstinence remains the mainstay of treatment, but the prognosis is poor after development of frank heart failure.
D000199:Actins / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002310:Cardiomyopathy, Alcoholic / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D002462:Cell Membrane / Q000187:drug effects; D004198:Disease Susceptibility; D000431:Ethanol / Q000494:pharmacology; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications; D007070:Immunoglobulin A / Q000097:blood; D007527:Isoenzymes / Q000097:blood; D008929:Mitochondria, Heart / Q000187:drug effects; D009206:Myocardium / Q000473:pathology; D009210:Myofibrils / Q000473:pathology; D009218:Myosins / Q000378:metabolism; D011379:Prognosis; D012737:Sex Factors
D000199:Actins; D007070:Immunoglobulin A; D007527:Isoenzymes; D000431:Ethanol; D009218:Myosins; D002118:Calcium