Oral rehydration therapy in malnourished infants with infectious diarrhoea.
The clinical response and changes in water and salt homeostasis was studied for 36 hours during oral rehydration therapy with a rehydration solution containing 60 mmol sodium/l (ORS60) in 14 malnourished 3- to 15-month-old Turkish infants with acute infectious diarrhoea. All patients were successfully rehydrated with this treatment. Sodium was efficiently absorbed from the gut and water balance was rapidly restored. Because of excess fluid retention following the initial rehydration period about 50% of the patients became oedematous. Urine volume and urinary sodium excretion were found to be much lower than in well-nourished patients of the same age with acute diarrhoea who were treated in the same way. In all of the malnourished infants the serum sodium level remained within the normal range during treatment. The results show that malnourished infants retain much more fluid and sodium than infants who are in a normal nutritional state. Excessive retention of water and salt seem to be due to an inability of the kidneys to control sodium and fluid homeostasis while orally administered sodium and fluid are being absorbed from the gut. The results show that ORT is safe and efficient in the treatment of malnourished infants with acute diarrhoea. But since these infants run a high risk of developing a severe retention of fluid and salt, and consequently may develop circulatory failure due to hypervolaemia during oral rehydration therapy, it is important to carefully monitor the volume of fluid that is given.
D000284:Administration, Oral; D001639:Bicarbonates / Q000008:administration & dosage; D003968:Diarrhea, Infantile / Q000150:complications / Q000628:therapy*; D004573:Electrolytes / Q000008:administration & dosage; D004927:Escherichia coli Infections / Q000628:therapy; D005440:Fluid Therapy; D005947:Glucose / Q000008:administration & dosage; D006706:Homeostasis; D006801:Humans; D007223:Infant; D008297:Male; D009748:Nutrition Disorders / Q000150:complications / Q000628:therapy*; D012400:Rotavirus Infections / Q000628:therapy; D012480:Salmonella Infections / Q000628:therapy; D014882:Water-Electrolyte Balance
D001639:Bicarbonates; D004573:Electrolytes; D005947:Glucose