Interaction between beta-lactam and other antibiotics.
The use of antibiotic combinations remains a necessity in certain clinical circumstances but must be approached with care since the drugs combined may prove antagonistic rather than synergistic. A variety of methods involving different principles are used for the evaluation of drug interactions in vitro; each technique has clear advantages and disadvantages. Information from the literature implies that there is generally a reasonable concordance between in vitro and in vivo results with drug combinations but that discordant results are not uncommon. More specifically, in vitro synergy does not always ensure a successful clinical outcome, but lack of synergy often correlates well with a high rate of therapy failure. A greater knowledge of the mechanisms underlying antibiotic interactions should improve the accuracy of predictions about the in vivo usefulness and safety of drug combinations.
D000617:Aminoglycosides / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000097:blood / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004336:Drug Antagonism; D004347:Drug Interactions; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D008826:Microbial Sensitivity Tests; D047090:beta-Lactams
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D047090:beta-Lactams