Adaptation of the Indochina I/CDC strain of Plasmodium falciparum to the squirrel monkey (Saimiri sciureus).
The Indochina I/CDC strain of Plasmodium falciparum was linearly passaged in squirrel monkeys (Saimiri sciureus) of 3 phenotypes. Splenectomized monkeys of Guyanan and Peruvian type developed high density parasitemias, but considerably lower than the mean peak parasitemia (greater than 10(6)/mm3) in Bolivian phenotype squirrel monkeys. Spleen-intact Bolivian and Peruvian squirrel monkeys all developed potentially lethal infections after linear passage of parasites from Saimiri and Aotus. For the evaluation of induced immunity to P. falciparum, the Indochina I/CDC strain in Saimiri will be a valuable model system.
D000818:Animals; D001029:Aotus trivirgatus / Q000469:parasitology; D002427:Cebidae / Q000469:parasitology*; D002738:Chloroquine / Q000494:pharmacology; D004195:Disease Models, Animal; D004351:Drug Resistance; D008288:Malaria / Q000469:parasitology*; D015767:Mefloquine; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development*; D011739:Pyrimethamine / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D012453:Saimiri / Q000469:parasitology*; D013156:Splenectomy; D013413:Sulfadoxine / Q000494:pharmacology
D011804:Quinolines; D013413:Sulfadoxine; D002738:Chloroquine; D015767:Mefloquine; D011739:Pyrimethamine