title: Bone and cartilage allotransplantation. A review of 14 years of research and clinical studies.
abstract: The authors review their experience of over 14 years in the field of osteochondral allotransplantation. Experimental studies demonstrated the immunogenicity of bone and cartilage, immunosuppression in skeletal transplantation models, and a subset of myeloid cells within bone marrow with strong immunogenic properties. Clinical results of knee joint resurfacing with fresh small-fragment osteochondral allografts have been best in posttraumatic joints. Experience with allograft reconstructions of skeletal defects after tumor surgery has been gratifying as a limb salvage procedure. Microvascular fibular autografts have been an important adjunct in massive reconstructive osteochondral transplantation.
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000601:surgery; D016025:Bone Transplantation; D001842:Bone and Bones / Q000276:immunology; D002358:Cartilage, Articular / Q000276:immunology / Q000637:transplantation*; D006085:Graft Survival; D006801:Humans; D007592:Joint Diseases / Q000601:surgery; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic