Antioxidants do not prevent the in vitro induction of Plasmodium falciparum crisis forms by human malaria-immune, TB or rabbit TNF serum.
Cultured Plasmodium falciparum was retarded in intraerythrocytic development by serum from malaria-immune adults, by human TB serum, and by rabbit tumor necrosis serum. Neither the potency nor efficacy of any of these sera was altered by a variety of antioxidants or oxygen-free radial scavengers, including ascorbate, alpha-tocopherol, BHT, cystine or cysteine, glutathione, histidine, phenylalanine, tryptophan, tyrosine, superoxide dismutase, catalase (or combination of the two enzymes), or by reducing the ambient O2 tension to 1%. It is thus unlikely that the antiparasitic activity of these inhibitory sera can be attributed to oxidative mechanisms.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004912:Erythrocytes / Q000469:parasitology; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D007106:Immune Sera / Q000276:immunology*; D008288:Malaria / Q000276:immunology*; D010100:Oxygen / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000254:growth & development* / Q000276:immunology; D011817:Rabbits; D014376:Tuberculosis / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha
D000975:Antioxidants; D006023:Glycoproteins; D007106:Immune Sera; D014409:Tumor Necrosis Factor-alpha; D010100:Oxygen