Effects of captopril on the sleep EEG of spontaneously hypertensive rats.
Intracerebroventricular captopril produces significantly different effects on the sleep electroencephalogram (EEG) of normotensive Wistar-Kyoto (WK) and spontaneously hypertensive rats (SHR). The compound produces a definite pattern of decrease in the percentage and power of the lower frequency EEG of the SHR. Corresponding action on the WK was confined to a general decrease in the power of the EEG. These findings suggest that certain components of the central renin-angiotensin system in the SHR are abnormal.
D000818:Animals; D002216:Captopril / Q000627:therapeutic use*; D004569:Electroencephalography; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007276:Injections, Intraventricular; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012084:Renin-Angiotensin System; D012890:Sleep / Q000502:physiology*
D002216:Captopril