Morphological and immunohistochemical study in Hodgkin's disease.
Histogenesis of different microscopical types of Hodgkin's disease was investigated in a series of 19 patients by morphological and immunohistochemical methods. The main changes affecting the lymphatic system occur in perivascular areas, which contain a great amount of thymic factor. The Hodgkin's and Reed-Sternberg cells appear to arise from the perivascular mesenchyme and some of them have cross-striated cytoplasm.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D006258:Head and Neck Neoplasms / Q000473:pathology; D006651:Histocytochemistry; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology; D008875:Middle Aged