Platelet dysplasia associated with megakaryoblastic leukemia in a dog.
In a case of megakaryoblastic leukemia in a dog, definitive diagnosis was made through use of specific cytochemical stains of circulating and bone marrow blast cells. Morphologic and functional abnormalities of platelets were revealed through transmission electron microscopy and in vitro aggregation of platelets after addition of adenosine diphosphate.
D000818:Animals; D001792:Blood Platelets / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D007953:Leukemia, Radiation-Induced / Q000473:pathology*; D008533:Megakaryocytes / Q000473:pathology; D008854:Microscopy, Electron; D013920:Thrombocythemia, Essential / Q000473:pathology / Q000662:veterinary*; D014916:Whole-Body Irradiation