Effect of ipriflavone on accessory sexual organs and bone metabolism in male rats.
Ipriflavone administered for 10 days to orchiectomized rats did not show androgenic or androgen-augmenting activities. The wet weight of the accessory sexual organs, and dry weight, ash content and calcium content of the femur were decreased by orchiectomy and were restored by androgen administration, but were not influenced by ipriflavone administered alone or in combination with androgen for 21 days. In intact rats, ipriflavone increased these variables slightly or definitely. Basal and calcium-stimulated calcitonin levels in orchiectomized rats were not influenced by pretreatment with estrone (0.25, 0.5 and 1 microgram/kg body weight/day) or ipriflavone (100 mg/kg body weight/day) for 42 days but were increased significantly by simultaneous pretreatment with these compounds. Therefore, it might be concluded that the increase in bone variables in intact rats that received ipriflavone resulted, at least in part, from the augmentation by ipriflavone of estrogen, which exists in the peripheral blood of male rats, in addition to intrinsic androgen, which maintains bone mineral content.
D000818:Animals; D001842:Bone and Bones / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000378:metabolism; D004970:Estrone / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology*; D005837:Genitalia, Male / Q000033:anatomy & histology / Q000187:drug effects*; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000033:anatomy & histology; D051381:Rats; D011919:Rats, Inbred Strains; D012669:Seminal Vesicles / Q000033:anatomy & histology; D013739:Testosterone / Q000494:pharmacology
D005419:Flavonoids; D007529:Isoflavones; D004970:Estrone; D013739:Testosterone; C018986:ipriflavone; D002116:Calcitonin; D002118:Calcium