title: [Adverse effects of drugs on the hearing organ].
abstract: Many different classes of drugs are known to produce ototoxicity. They include such commonly used agents as salicylates and diuretics but the most important of them are the ototoxic antibiotics, particularly those of the aminoglycoside group. The toxic effects result from an initial selective damaging to the organ of Corti (hair cells) or the secretory cells of the stria vascularis. Both damaging mechanisms are dose-dependent. The ototoxic risk of the different drugs is described.
mesh_terms: D000617:Aminoglycosides / Q000009:adverse effects; D000700:Analgesics / Q000009:adverse effects; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D000995:Antitubercular Agents / Q000009:adverse effects; D003051:Cochlea / Q000187:drug effects*; D004232:Diuretics / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D006311:Hearing Disorders / Q000139:chemically induced*; D006801:Humans
chemical_list: D000617:Aminoglycosides; D000700:Analgesics; D000889:Anti-Arrhythmia Agents; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000929:Antidepressive Agents, Tricyclic; D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D004232:Diuretics
vernacular_title: Medikament-Nebenwirkungen auf das Hörorgan.