High-carbohydrate diet: antinatriuretic and blood pressure response in normal men.
The hypothesis that high-carbohydrate feeding leads to increased insulin secretion, sodium retention, and elevation in blood pressure was examined in seven healthy men. A baseline 7-day balance study on low (13%) or high (52%) carbohydrate was followed by a 2-wk balance on the alternate diet and a 1-wk balance on the baseline diet. Results indicated that changing carbohydrate intake caused a rapid (2-3 day) inverse change in urinary sodium excretion and balance. By the second week, however, urinary-sodium level returned to baseline accompanied by an inverse change in plasma aldosterone. No significant rise in blood pressure was detected throughout the study. High-carbohydrate feeding promotes sodium retention in normal subjects, but the effect is counterregulated by a reduction in plasma aldosterone. A high-carbohydrate diet in healthy subjects does not cause a significant short-term increase in blood pressure.
D000450:Aldosterone / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects*; D002712:Chlorides / Q000652:urine; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D012083:Renin / Q000097:blood; D013997:Time Factors
D002712:Chlorides; D004040:Dietary Carbohydrates; D007328:Insulin; D000450:Aldosterone; D012083:Renin