Defibrotide protects rabbit myocardium from ischemia: relationship with the eicosanoid system.
In the isolated rabbit heart preparation we studied the action of defibrotide--a natural polydesoxyribonucleotide from mammalian lungs--on the ischemic myocardial injury and on concentration of prostaglandin-like material in the perfusate. Defibrotide counteracted the ischemic myocardial contracture and significantly improved the recovery of cardiac contractibility and normalization of the rhythm in the postischemic period. This effect seems to be correlated with the concentration of the prostaglandin-like material in the cardiac perfusate. A simultaneous infusion of indomethacin inhibited both the protective effect of defibrotide and the prostaglandin-like material release from the cardiac muscle.
D000818:Animals; D003327:Coronary Disease / Q000517:prevention & control*; D004195:Disease Models, Animal; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011089:Polydeoxyribonucleotides / Q000494:pharmacology / Q000627:therapeutic use*; D011453:Prostaglandins / Q000378:metabolism*; D011817:Rabbits
D005343:Fibrinolytic Agents; D011089:Polydeoxyribonucleotides; D011453:Prostaglandins; C036901:defibrotide; D007213:Indomethacin