Impaired contractile motility of the gallbladder after gastrectomy.
Contractile motility of the gallbladder was compared using a real-time ultrasonography in 13 patients with gastric ulcer and 31 patients with gastric cancer who had undergone either subtotal or total gastrectomy within 1 month previously. Contractile motility of the gallbladder after oral administration of dried egg yolk (Daiyan, Maruishi, Osaka), which was slightly but not significantly reduced in patients with gastric ulcer, was remarkedly impaired in patients with gastric cancer who had either subtotal or total gastrectomy including radical lymph node dissection. Especially, maximum contractile rate after Daiyan in Billroth II patients was significantly reduced than that of Billroth I patients. Intramuscular injection of naloxone (0.4 mg), which had no effects on contractions after Daiyan in healthy subjects, significantly improved the hypomotility in response to Daiyan in these gastric cancer patients. It was suggested, therefore, that the possible roles of various anatomical and mechanical changes resulting from gastrectomy including vagotomy and sympathectomy, and in particular exclusion of duodenum from digestive circuits and relative or absolute excess of endogenous opioids, were involved in the control of the gallbladder motility within 1 month after gastrectomy including lymphadenectomy.
D003082:Colectomy / Q000009:adverse effects; D004530:Egg Yolk; D005704:Gallbladder / Q000187:drug effects / Q000503:physiopathology*; D005743:Gastrectomy / Q000009:adverse effects*; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology; D013274:Stomach Neoplasms / Q000503:physiopathology / Q000601:surgery; D013276:Stomach Ulcer / Q000503:physiopathology / Q000601:surgery; D013562:Sympathectomy / Q000009:adverse effects; D014463:Ultrasonography; D014628:Vagotomy / Q000009:adverse effects
D009270:Naloxone