title: [Changes in urinary NAG activity in patients with climacteric syndrome treated with estrogens].
abstract: The behaviour of urinary NAG activity was studied in patients during menopause, some of whom were given estrogen therapy due to severe vasomotor symptoms (hot flushes etc.). One group of these patients revealed slightly higher than normal blood pressure. A second group had slight arterial hypertension and pancreatic diabetes. The third group consisted of apparently healthy menopausal women. The significant increase in enzymuria in the first two groups suggests that blood pressure should be carefully checked before starting estrogen therapy. Furthermore this treatment should be given very cautiously and under constant surveillance in the presence of slight hypertension. In patients with diabetes or more severe hypertension, estrogens should never be given.
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine*; D002979:Climacteric / Q000187:drug effects / Q000652:urine*; D003920:Diabetes Mellitus / Q000652:urine; D004967:Estrogens / Q000627:therapeutic use*; D005260:Female; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D006973:Hypertension / Q000652:urine; D008875:Middle Aged
chemical_list: D004967:Estrogens; D006596:Hexosaminidases; D000118:Acetylglucosaminidase
vernacular_title: Variazioni dell'attività NAG-urinaria in pazienti con sindrome climaterica trattate con estrogeni.