title: Pathogenesis of early neonatal hypocalcemia: studies of serum calcitonin, gastrin, and plasma glucagon.
abstract: In 64 maternal-infant pairs, we tested the hypotheses that serum calcitonin, serum gastrin, and plasma glucagon concentrations are elevated in infants at risk for early neonatal hypocalcemia, and that elevated serum gastrin and plasma glucagon result in elevated serum calcitonin and low serum calcium values in neonates. Serum Ca declined significantly in neonates at 24 hours of age, and was inversely correlated with serum calcitonin. Cord serum calcitonin, gastrin, and plasma glucagon concentrations rose significantly at 24 hours of age. Cord calcitonin was significantly higher in preterm compared with term infants, and there was no significant difference between asphyxiated and nonasphyxiated preterm neonates; in term neonates cord calcitonin concentration was inversely correlated with Apgar scores at 1 and 5 minutes. Cord calcitonin was not correlated with cord gastrin or glucagon. Cord and 24-hour gastrin and glucagon values were not related to prematurity; cord glucagon, but not gastrin, was related to birth asphyxia. We conclude that (1) serum calcitonin, gastrin, and plasma glucagon values rise postnatally; cord calcitonin is elevated in preterm and in asphyxiated term infants; serum calcitonin concentration does not correlate with the elevated serum gastrin and plasma glucagon values; and at 24 hours of age, decreased serum Ca is correlated with serum calcitonin, and hence calcitonin might play a role in the pathogenesis of early neonatal hypocalcemia.
mesh_terms: D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000097:blood; D002116:Calcitonin / Q000097:blood*; D005312:Fetal Blood; D005755:Gastrins / Q000097:blood*; D005865:Gestational Age; D005934:Glucagon / Q000097:blood*; D006801:Humans; D006996:Hypocalcemia / Q000097:blood / Q000209:etiology*; D007231:Infant, Newborn; D008903:Minerals / Q000097:blood; D011446:Prospective Studies
chemical_list: D005755:Gastrins; D008903:Minerals; D002116:Calcitonin; D005934:Glucagon