title: Colonic hemorrhage produced in mice by a unique vero cell cytotoxin from an Escherichia coli strain that causes hemorrhagic colitis.
abstract: A Vero cell cytotoxin that produces colonic lesions and subsequent colonic hemorrhage in mice has been purified from a strain of Escherichia coli O157:H7 that causes hemorrhagic colitis in humans. This toxin is different in physicochemical properties from the Shiga-like toxin previously associated with this organism and may be responsible for the unique diffuse mucosal hemorrhage in the colon of individuals with E. coli O157:H7 infections.
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000302:isolation & purification / Q000633:toxicity*; D003092:Colitis / Q000382:microbiology; D003106:Colon / Q000473:pathology; D003108:Colonic Diseases / Q000209:etiology* / Q000473:pathology; D003603:Cytotoxins / Q000302:isolation & purification / Q000633:toxicity*; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000382:microbiology; D006471:Gastrointestinal Hemorrhage / Q000209:etiology* / Q000473:pathology; D007526:Isoelectric Point; D007684:Kidney Tubules / Q000473:pathology; D007928:Lethal Dose 50; D008221:Lymphoid Tissue / Q000473:pathology; D051379:Mice; D008813:Mice, Inbred ICR; D008970:Molecular Weight; D022622:Shiga Toxin 1
chemical_list: D001427:Bacterial Toxins; D003603:Cytotoxins; D022622:Shiga Toxin 1