title: A biophysical and histological analysis of factors that lead to aortic rupture in normal and lathyritic turkeys.
abstract: These experiments were designed to determine if local differences in elastic properties or wall structure contributed to the development of aortic rupture in turkeys. Static elastic properties were measured from pressure-volume curves of cylindrical segments of upper and lower thoracic aorta and innominate artery in two groups of lathyritic birds and two age-matched control groups. The biggest changes were in the young lathyritic group that was on 0.04% beta-aminoproprionitrile at 3 weeks of age and continued for 2, 3, or 4 weeks. Much smaller changes were seen in the older group that started on 0.05% beta-aminoproprionitrile at 6 weeks of age for 10 days and then 0.02% beta-aminoproprionitrile for the next 9-12 weeks. The biggest changes were seen in the abdominal aorta, which ruptured spontaneously in 50% of the young lathyritic group. The birds had a marked decrease in the number of elastin layers per unit wall thickness. Analysis of the elastic diagrams showed that the elastance of both elastin and collagen were altered in the young lathyritic group. Rupture appeared to follow partial dissection of plaques, but true longitudinal dissection did not occur.
mesh_terms: D000629:Aminopropionitrile / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D001019:Aortic Rupture / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D016122:Brachiocephalic Trunk / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D003094:Collagen / Q000502:physiology; D004548:Elasticity; D004549:Elastin / Q000502:physiology; D007842:Lathyrism / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D011201:Poultry Diseases / Q000473:pathology / Q000503:physiopathology*; D014422:Turkeys
chemical_list: D000629:Aminopropionitrile; D003094:Collagen; D004549:Elastin