title: [Idiopathic hypercalciuria--recent pathogenetic and diagnostic aspects].
abstract: The term "hypercalciuria" is not uniformly applied. Recent investigations show that the upper normal limits of 24-hour calciuria are above the originally defined 7.5 mmol in men in 6.25 mmol in women. There is no clear evidence that 24-hour calciuria is more often increased in idiopathic calcium stone formers than in healthy controls with normal calcium metabolism. Because of a disordered regulation of 1,25-dihydroxy-vitamin D3-production, the serum-1,25-dihydroxy-vitamin D3 is increased in idiopathic calcium stone formers. A calcium loading test during undisturbed individual calcium homeostasis reveals increased intestinal calcium absorption in calcium stone formers. Metabolic evaluations are often not performed under the same conditions as those in which the stone formation occurred. As long as the primary metabolic defect has not been identified, classification into "absorptive" and "renal hypercalciuria" does not seem to be justified.
mesh_terms: D002118:Calcium / Q000652:urine*; D002128:Calcium Metabolism Disorders / Q000150:complications; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000378:metabolism; D008297:Male; D014545:Urinary Calculi / Q000378:metabolism
chemical_list: D002118:Calcium
vernacular_title: Idiopathische Hypercalciurie--neuere pathogenetische und diagnostische Aspekte.