Substrate specificity in the stimulation of intestinal ornithine decarboxylase activity by refeeding after starvation.
Jejunal loops in 3-day-fasted rats were perfused with hexoses and amino acids to test for their ability to stimulate intestinal ornithine decarboxylase activity. Intraluminal L- and D-glucose, galactose and 3-O-methylglucose were potent stimulants, while D-fructose and L-leucine were not. Intravenously infused D-glucose was also without effect. Induction of ornithine decarboxylase therefore appears to involve a receptor-mediated event which is probably located at the luminal cell surface.
D000818:Animals; D005215:Fasting; D005947:Glucose / Q000494:pharmacology; D006601:Hexoses / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000097:blood; D007583:Jejunum / Q000201:enzymology*; D007700:Kinetics; D007930:Leucine / Q000494:pharmacology; D008297:Male; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013379:Substrate Specificity
D006601:Hexoses; D007328:Insulin; D009955:Ornithine Decarboxylase; D007930:Leucine; D005947:Glucose