Effect of deoxycholic acid on lipoprotein and apolipoprotein levels in patients with familial hypercholesterolemia.
Seventeen patients with familial hypercholesterolemia (9 males and 8 females) were treated with 1000 mg deoxycholic acid or placebo daily during 2 weeks in a double-blind, randomised cross-over fashion. A wash-out period was held between the two periods of therapy. Clinical chemical parameters, lipoprotein cholesterol and apolipoproteins were measured before and after each period. Low density lipoprotein cholesterol was reduced by 7.5% and LDL-apo B by 5.6%. Only the latter change was significantly different from the corresponding changes in the placebo period (P less than 0.05). High density lipoprotein cholesterol did not change. Apolipoprotein A-I decreased by 4% (P less than 0.05). Apolipoprotein A-II did not change. While taking deoxycholic acid, most patients had abdominal discomfort and/or diarrhoea. The serum transaminases increased in 7 patients taking this drug and in none while taking a placebo. We conclude that this therapy is of little value in hypercholesterolemic patients.
D000328:Adult; D001053:Apolipoproteins / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D002986:Clinical Trials as Topic; D003840:Deoxycholic Acid / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000188:drug therapy*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D008074:Lipoproteins; D014280:Triglycerides; D003840:Deoxycholic Acid; D002784:Cholesterol