[Pharyngeal viral population in 3- to 6-year-old children before and after influenza immunization using the NIVGRIP vaccine administered orally].
Immunofluorescence techniques were used to investigate the incidence of viral antigens in exfoliated pharyngeal cells collected from 94 3-6-year-old children living in a collectivity, vaccinated by oral route with NIVGRIP inactivated influenza vaccine. The vaccination resulted in a significant decrease of IF-positive subjects from 80% before to 39% after immunization, indicating a fall in the virus carriage level. The percentage of children in which two or more viral antigens were found also decreased from 72% to 33%. As regards the incidence of different viruses, the complete disappearance of influenza antigens and a marked decrease of the other investigated viral agents were recorded.
D000284:Administration, Oral; D000956:Antigens, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005455:Fluorescent Antibody Technique; D006801:Humans; D007114:Immunization; D009980:Influenza A virus / Q000276:immunology / Q000302:isolation & purification*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D007251:Influenza, Human / Q000382:microbiology / Q000517:prevention & control*; D010614:Pharynx / Q000382:microbiology*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
D000956:Antigens, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated
Etude de la population virale du pharynx chez des enfants âgés de 3 à 6 ans avant et après l'immunisation contre la grippe à l'aide du vaccin NIVGRIP administré par voie orale.