[Effects of SIN-1 on the activation of phospholipase C and calcium mobilization induced by thrombin in blood platelets].
Ca2+ influx, Ca2+ mobilization and phospholipase C activation have been determined in human platelets stimulated by thrombin in the presence of increasing concentrations of SIN-1. Preliminary data indicate a major inhibitory effect of SIN-1 on Ca2+ influx, but also a significant inhibition of phospholipase C. However, the decrease of serotonin secretion by SIN-1 seems to be more related to phospholipase C inhibition. These data are discussed in relation to the known effects of SIN-1 on cGMP content of platelets.
D001792:Blood Platelets / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D008981:Molsidomine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013917:Thrombin / Q000494:pharmacology; D010738:Type C Phospholipases / Q000378:metabolism*
C002385:linsidomine; D008981:Molsidomine; D010738:Type C Phospholipases; D013917:Thrombin; D002118:Calcium
Effets du SIN-1 sur l'activation de la phospholipase C et les mouvements calciques induits par la thrombine dans les plaquettes sanguines.