[Sensitivity to influenza infection of X-ray-irradiated animals and the protective effect of a thymus extract].
The A 2/Romania 1/73 (H3N2) strain of influenza virus at the 15th passage on chick embryos was compared to the mouse adapted A0/PR8/34 (H0N1) strain, as regards pathogenicity for X-ray irradiated mice. Irradiated mice showed a greater sensitivity to influenza infection than nonirradiated controls, irrespective of the strain used: hemagglutinating (HA) titers were constantly higher in the first group of animals. Administration of a polypeptidic thymus extract to irradiated mice inoculated with the A0/PR8 strain had a protective effect and was followed by a decrease in mean HA titer from 1/3077 to 1/164. The authors discuss the possible mechanisms of the viral multiplication rate increase in irradiated animals and of the higher resistance against influenza infection noted in thymus-extract treated animals.
D000818:Animals; D002642:Chick Embryo; D004198:Disease Susceptibility; D004307:Dose-Response Relationship, Radiation; D009980:Influenza A virus / Q000472:pathogenicity; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000209:etiology* / Q000517:prevention & control; D013950:Thymus Gland; D014020:Tissue Extracts / Q000627:therapeutic use*; D014916:Whole-Body Irradiation
D014020:Tissue Extracts
Sensibilité à l'infection grippale des animaux irradiés par des rayons X et effet protecteur d'un extrait de thymus.