Identification of novel erythromycin derivatives in mother liquor concentrates of Streptomyces erythraeus.
The identification of five novel compounds, pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-N-demethylerythromycin A-6,9-hemiketal, 5-O-beta-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13----C11 trans-lactonization. The five compounds have very little antimicrobial activity.
D001419:Bacteria / Q000187:drug effects; D003470:Culture Media; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000032:analysis*; D013329:Structure-Activity Relationship
D003470:Culture Media; D004917:Erythromycin