Autoconditioning factor relieves ethanol-induced growth inhibition of Saccharomyces cerevisiae.
Viable Saccharomyces cerevisiae suspended in medium containing growth-inhibiting concentrations of ethanol produce a metabolite that relieves growth inhibition. This autoconditioning of the medium by yeasts is due to the formation of small amounts (0.01%, vol/vol) of acetaldehyde. The effect is duplicated precisely in fresh medium by the addition of acetaldehyde. Acetaldehyde does not increase the yield of or accelerate ethanol production by the organism. Ethanol-induced modifications of membrane order in the plasma membranes, as measured by steady-state fluorescence anisotropy of 1,6-diphenyl-1,3,5-hexatriene, were not resolved by exogenously added acetaldehyde.
D000079:Acetaldehyde / Q000378:metabolism; D002462:Cell Membrane / Q000648:ultrastructure; D003470:Culture Media; D000431:Ethanol / Q000378:metabolism*; D005285:Fermentation; D012441:Saccharomyces cerevisiae / Q000254:growth & development* / Q000378:metabolism / Q000648:ultrastructure
D003470:Culture Media; D000431:Ethanol; D000079:Acetaldehyde