title: [Antibacterial activity of cephem antibiotics against isolates from clinical specimens at the Yokohama City University Hospital].
abstract: Minimum inhibitory concentrations (MICs) of cephem antibiotics against 405 strains belonging to 17 species of clinical isolates were investigated using the standard method of the Japanese Congress of Chemotherapy. The results obtained are summarized below. Cephem antibiotics showed weak antibacterial activities against Enterococcus sp., B. fragilis and S. marcescens. S. pneumoniae, S. agalactiae, E. coli, K. pneumoniae and P. mirabilis were susceptible to cephem antibiotics. Cephem antibiotics of the 1st and the 2nd generations showed weak antibacterial activity against Citrobacter sp. and E. cloacae, while cephem antibiotics of 3rd generation had a good antibacterial activity against these species. Cephem antibiotics of the 2nd and the 3rd generations showed high antibacterial activity against H. influenzae and indole positive Proteus group. Cefoperazone showed high antibacterial activity against P. aeruginosa. Resistance to latamoxef, ceftizoxime and cefoxitin was observed among Staphylococcus sp., while the MICs of other antibiotics against Staphylococcus sp. were fairly low. Number of strains resistant to the 3rd cephem antibiotics seems to be increasing because the 3rd generation of cephem antibiotics have been used frequently. Further investigation will be required on resistant organism to these antibiotics including beta-lactamase producing strains.
mesh_terms: D002511:Cephalosporins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007422:Intestines / Q000382:microbiology; D007709:Klebsiella / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
chemical_list: D002511:Cephalosporins