[Transplantation of allogeneic bone marrow treated in vitro with Campath-1 monoclonal antibody].
Out of 14 bone marrow transplants, 12 patients received transplantations with allogeneic bone marrow after in vitro T-cell depletion with monoclonal Campath 1. The patients also received short term cyclosporin. This small series is in agreement with the results of larger series using T-depleted marrow as far as the prevention of graft versus host disease is concerned, and with respect to mixed chimerism, slow take, late rejection and, possibly, increased risk of recurrence.
D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D006402:Hematologic Diseases / Q000628:therapy*; D006801:Humans; D008212:Lymphocyte Depletion; D008875:Middle Aged
D000911:Antibodies, Monoclonal
Transplantation de moelle osseuse allogénique traitée in vitro par l'anticorps monoclonal Campath-1.