Motor abnormalities in weaver mutant mice.
Weaver mutant mice lose mainly cerebellar granule cells. Motor abnormalities included less activity in a hole-board test and a loss of balance in two equilibrium tests. It was noted that the weaver mutants also displayed paw clasping responses when held by the tail of a sort never seen in normal mice. The role of the cerebellum in these abnormalities is discussed.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D005121:Extremities / Q000502:physiology; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000502:physiology*; D009068:Movement; D004856:Postural Balance