Membrane activity, antioxidant, antiaggregatory and antihemolytic properties of four calcium channel blockers.
Four calcium channel blockers: nifedipine, fendiline, verapamil and diltiazem have been found to possess different affinity to cytomembranes of platelets and erythrocytes. Nifedipine bound to proteins of the external site of cytomembranes. Verapamil and fendiline possessed affinity to lipids of the cytoplasmic site of the cytomembranes. Diltiazem bound practically neither to erythrocyte nor to platelet membranes. All tested compounds were antioxidants, the strongest being fendiline. Antiaggregatory and antihemolytic properties of tested compounds were roughly correlated with their membrane activity.
D000818:Animals; D000975:Antioxidants; D001792:Blood Platelets / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000378:metabolism / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism; D004110:Diltiazem / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects; D005275:Fendiline / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects*; D066298:In Vitro Techniques; D009543:Nifedipine / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology
D000975:Antioxidants; D002121:Calcium Channel Blockers; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine; D005275:Fendiline