Isolation of Inoue-Melnick virus from human meningioma-derived cell cultures and detection of antibody in patients with meningioma.
Inoue-Melnick virus (IMV) was isolated from six of seven human meningioma-derived cell cultures, while the virus was not isolated from six other brain tumor cell cultures. Sera of 145 consecutive neurosurgical inpatients were tested for IMV-neutralizing antibody. Of 26 patients with meningioma, 22 were positive for IMV antibody (84.6%). Of the remaining 119 patients, 16 were positive.
D000914:Antibodies, Viral / Q000032:analysis*; D002478:Cells, Cultured; D005260:Female; D006564:Herpesviridae / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000382:microbiology*; D008579:Meningioma / Q000276:immunology / Q000382:microbiology*
D000914:Antibodies, Viral