T cell factors involved in the regulation of the IgE synthesis.
The IgE-potentiating and IgE-suppressive factors share a common structural gene and therefore a common polypeptide chain, and their biologic activities are decided by a post-translational glycosylation process. Under physiological conditions, this process is controlled by two T cell factors, i.e., the glycosylation-enhancing factor (GEF) and glycosylation-inhibiting factor (GIF). GIF is a fragment of phosphorylated lipocortin and has immunosuppressive effects. Repeated injections of this lymphokine into antigen-primed mice switched their T cells from the formation of IgE-potentiating factor to the formation of IgE-suppressive factor and facilitated the generation of antigen-specific suppressor T cells, which form antigen-specific GIF upon antigenic stimulation. The antigen-specific GIF suppressed the antibody response in a carrier-specific manner and has properties similar to antigen-specific suppressor T cell factors.
D000818:Animals; D000917:Antibody Formation; D004247:DNA / Q000032:analysis; D006801:Humans; D007108:Immune Tolerance; D007073:Immunoglobulin E / Q000096:biosynthesis*; D008222:Lymphokines / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D051379:Mice; D008815:Mice, Inbred Strains; D029584:Prostatic Secretory Proteins; D013601:T-Lymphocytes / Q000502:physiology*
D008222:Lymphokines; D029584:Prostatic Secretory Proteins; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors; D007073:Immunoglobulin E; D004247:DNA