Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut.
By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78-107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78-107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78-107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.
D000818:Animals; D005934:Glucagon / Q000378:metabolism* / Q000502:physiology; D007082:Ileum / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism* / Q000502:physiology; D013552:Swine
D007328:Insulin; D010455:Peptides; D005934:Glucagon