Methylglyoxal in beverages and foods: its mutagenicity and carcinogenicity.
Methylglyoxal was found to induce mutations in Salmonella typhimurium strains TA100, TA102 and TA104, gene conversion in Saccharomyces cerevisiae strain D7, and diphtheria toxin resistance mutation in Chinese hamster lung cells. Methylglyoxal was detected in coffee, whiskey, a soft drink, toasted bread and soy sauce. The mutagenicity of methylglyoxal was suppressed by sulfite, cysteine, glutathione and dithiothreitol, and enhanced by hydrogen peroxide. Methylglyoxal induced sarcomas in rats at the site of its subcutaneous injection.
D000447:Aldehydes / Q000633:toxicity*; D000818:Animals; D002478:Cells, Cultured; D003069:Coffee / Q000633:toxicity*; D006224:Cricetinae; D005504:Food Analysis; D005785:Gene Conversion / Q000187:drug effects; D009152:Mutagenicity Tests; D009374:Neoplasms, Experimental / Q000139:chemically induced; D011765:Pyruvaldehyde / Q000032:analysis / Q000633:toxicity*; D051381:Rats; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects; D013438:Sulfhydryl Compounds
D000447:Aldehydes; D003069:Coffee; D013438:Sulfhydryl Compounds; D011765:Pyruvaldehyde