Community acquired infections in children on maintenance cyclosporine therapy.
Cyclosporine has profound immunosuppressive properties. We reviewed our experience of community acquired infections in 62 children who received the drug from 2 to 36 months. 36 children received the drug for a renal transplant for a mean of 18 months. There were 3 minor and one major episode of infection in this group. The frequency of both minor and major infections in cyclosporine recipients was significantly lower when compared with a group of renal recipients treated with azathioprine. 26 children received cyclosporine for 2 months for resistant nephrotic syndrome. This group had one major and one minor episode of infection. Despite the relative safety of cyclosporine recipients from infectious complications, a more prolonged follow up is necessary.
D000293:Adolescent; D001379:Azathioprine / Q000009:adverse effects; D001424:Bacterial Infections / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D003524:Cyclosporins / Q000009:adverse effects*; D004927:Escherichia coli Infections / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D014552:Urinary Tract Infections / Q000209:etiology; D014777:Virus Diseases / Q000209:etiology
D003524:Cyclosporins; D001379:Azathioprine