The metabolism of aromatic amines.
Aromatic amines are of general interest in drug metabolism and some are a health hazard, particularly as bladder carcinogens. Conditions for the biological ring- and N-oxidation of aniline and its derivatives are reviewed. The metabolism of 2-naphthylamine and aminobiphenyls and the involvement of metabolites of aromatic amines in bladder cancer is discussed.
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism*; D006801:Humans; D011083:Polycyclic Compounds / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D002273:Carcinogens; D011083:Polycyclic Compounds