Method of lesioning brainstem determines seizure probability.
We examined 3 different methods of brainstem lesioning to assess their propensities to evoke seizures in the early postoperative period. Lesioning by electrolysis or microinjection of the neurotoxin, N-methyl-D,L-aspartate, caused seizures, but lesioning by thermocoagulation (radiofrequency current) did not. In paradigms in which postoperative lesion-induced seizures could confound interpretation of experimental results, the thermocoagulative method offers an important advantage.
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives; D001522:Behavior, Animal / Q000502:physiology; D001933:Brain Stem / Q000502:physiology*; D004556:Electric Injuries / Q000150:complications; D006358:Hot Temperature; D008297:Male; D016202:N-Methylaspartate; D009462:Neurology / Q000379:methods*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology
D001224:Aspartic Acid; D016202:N-Methylaspartate