title: Evaluation of two local anaesthetic sprays for the relief of post-episiotomy pain.
abstract: Aerosol formulations of lignocaine (5%) and cinchocaine (2%) were compared with a water-only placebo spray in a single-dose study in 76 primiparous patients complaining of moderate or severe post-episiotomy pain. In comparison with a water-only placebo, both local anaesthetic formulations gave significant relief when administered to the perineal wound but the lignocaine spray proved to be the more effective. The only side-effect reported was slight stinging occurring immediately after administration of the lignocaine spray in 2 cases. Serum concentrations of local anaesthetic post-administration were negligible. An interesting finding was that breast-feeding patients responded less well to this form of analgesia than patients in whom lactation had been suppressed with frusemide.
mesh_terms: D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000698:Analgesia / Q000379:methods*; D001942:Breast Feeding; D002986:Clinical Trials as Topic; D003992:Dibucaine / Q000008:administration & dosage*; D004841:Episiotomy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D010149:Postoperative Pain / Q000188:drug therapy*; D049590:Postpartum Period; D011247:Pregnancy; D011897:Random Allocation; D013997:Time Factors
chemical_list: D000336:Aerosols; D008012:Lidocaine; D003992:Dibucaine