Plasma exchange with prostaglandin I2 and ACD solution: comparative effects.
Discontinuous plasma exchange with prostaglandin I2 (5 ng/kg/min) and low dosage heparin (5-6 IU/kg/min) (treatment I), and ACD solution alone (treatment II) was studied. During both treatments the activated partial thromboplastin time remained within the normal range. After treatment I platelet count was not decreased but in vitro platelet aggregation was reduced (p less than 0.001). After treatment II platelet count was reduced and in vitro platelet aggregation unchanged. Prostaglandin I2 at this dosage caused no cardiovascular complications. The physiopathological implications of these differences are discussed.
D000328:Adult; D019343:Citric Acid; D011464:Epoprostenol / Q000627:therapeutic use*; D005947:Glucose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D010951:Plasma Exchange
C002113:acid citrate dextrose; D019343:Citric Acid; D006493:Heparin; D011464:Epoprostenol; D005947:Glucose