Pancreatic glucagon and bombesin inhibit meal size in ventromedial hypothalamus-lesioned rats.
The effects of intraperitoneal injections of pancreatic glucagon and bombesin on meal size were tested in female rats in the dynamic phase of ventromedial hypothalamic (VMH) hyperphagia. Both pancreatic glucagon (100-2500 micrograms/kg) and bombesin (4-16 micrograms/kg) inhibited meal size in a dose-related manner. Percent inhibitions of meal size in VMH-lesioned and control rats did not differ significantly. These results suggest that the VMH is not necessary for peripheral administration of either pancreatic glucagon or bombesin to elicit postprandial satiety.
D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001839:Bombesin / Q000494:pharmacology*; D002149:Energy Intake; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D014697:Ventromedial Hypothalamic Nucleus / Q000502:physiology*
D005934:Glucagon; D001839:Bombesin