Dissolution of gallstones using cholecystostomy tube in the pig.
Cholecystostomy catheters and human cholesterol gallstones were implanted surgically in the gallbladders of eight pigs. Through the catheters, mono-octanoin or sterile water (H2O) was infused from two to seven days. The mono-octanoin dissolved pure cholesterol gallstones smaller than 200 g. There was no stone dissolution with infusion of sterile water and only one stone larger than 250 g was dissolved with mono-octanoin. Side effects included moderate-to-severe inflammation and ulceration of the gallbladder with mono-octanoin instillation, which precludes its widespread use with the present treatment regimen. Infusion of water caused little gallbladder irritation.
D000818:Animals; D002210:Caprylates; D002408:Catheters, Indwelling; D002769:Cholelithiasis / Q000473:pathology / Q000628:therapy*; D005704:Gallbladder / Q000473:pathology / Q000601:surgery; D005989:Glycerides / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D011677:Punctures; D012995:Solubility; D013552:Swine
D002210:Caprylates; D005989:Glycerides; C025343:monooctanoin