Interference by goat-derived anti-lymphocyte globulin in a double-antibody radioimmunoassay of digoxin.
Therapy with anti-lymphocyte and anti-thymocyte globulins, two animal-derived preparations used as immunosuppressive agents, results in high concentrations of foreign immunoglobulin circulating in plasma. We describe a case that illustrates how the presence of these immunoglobulins can interfere with double-antibody radioimmunoassay procedures.
D000818:Animals; D002675:Child, Preschool; D004077:Digoxin / Q000097:blood*; D005189:False Positive Reactions; D005260:Female; D006041:Goats; D016027:Heart Transplantation; D006736:Horses; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000276:immunology*; D011863:Radioimmunoassay
D007136:Immunoglobulins; D004077:Digoxin