Expression of interleukin-1 in Reed-Sternberg cells and neoplastic cells from true histiocytic malignancies.
Interleukin-1, a peptide produced by monocytes, histiocytes, and interdigitating reticulum cells, plays an important role in the regulation of immune function. In this styde, we examined the production of interleukin-1 in 115 patients with a variety of human lymphomas by using a rabbit anti-interleukin-1 antibody and the immunoperoxidase technique. Interleukin-1 was detected in Reed-Sternberg cells from 20 patients with Hodgkin's disease as well as in neoplastic cells from 9 patients with true histiocytic lymphoma or malignant histiocytosis. In the other 86 cases, which included T- and B-cell lymphomas, no interleukin-1 could be detected. This result indicates a close relationship between Hodgkin's disease and true histiocytic malignancies and provides additional evidence to support our hypothesis that Reed-Sternberg cells are related to interdigitating reticulum cells.
D000818:Animals; D006644:Histiocytes / Q000473:pathology*; D006651:Histocytochemistry; D006689:Hodgkin Disease / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007375:Interleukin-1 / Q000096:biosynthesis*; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000473:pathology*; D011817:Rabbits
D007375:Interleukin-1