[Competitive interaction of serotonin and the dye acridine orange with DNA].
The interaction of serotonin and acridine orange dye with DNA isolated from bacterium Escherichia coli and the yeast Candida utilis has been analysed by spectrofluorimetric method. Using data on competitive binding to DNA of serotonin and acridine orange, known as DNA intercalator, a conclusion concerning the formation of intercalated complex between serotonin and DNA has been made. It is shown that for yeast DNA the constant of intercalated binding of serotonin is 3,5-fold smaller than for the bacterial one.
D000165:Acridine Orange / Q000378:metabolism*; D001667:Binding, Competitive; D002175:Candida; D004269:DNA, Bacterial / Q000378:metabolism*; D004271:DNA, Fungal / Q000378:metabolism*; D004926:Escherichia coli; D007364:Intercalating Agents; D012701:Serotonin / Q000378:metabolism*; D012996:Solutions; D013050:Spectrometry, Fluorescence
D004269:DNA, Bacterial; D004271:DNA, Fungal; D007364:Intercalating Agents; D012996:Solutions; D012701:Serotonin; D000165:Acridine Orange
Konkurentnoe vzaimodeĭstvie serotonina i krasitelia akridinovogo oranzhevogo s DNK.