title: Effect of capsaicin on neurites of cultured dorsal root ganglia and isolated neurons of chick embryos.
abstract: The effects of capsaicin on neurites of cultured chick lumbar dorsal root ganglia and their isolated single neurons were investigated. Capsaicin-treated neurites showed a disappearance of their tips, dumpling-like structures, and retardation as a result of degeneration. However, some of the retarded neurites showed a reextension. By electron microscopy the degeneration appeared similar to that caused by beta,beta'-iminodipropionitrile with respect to segregation of the cytoskeleton. This finding provides support for the idea that capsaicin inhibits axonal transport.
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000648:ultrastructure; D002211:Capsaicin / Q000494:pharmacology*; D002469:Cell Separation; D002478:Cells, Cultured; D002642:Chick Embryo; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects*; D009410:Nerve Degeneration / Q000187:drug effects
chemical_list: D002211:Capsaicin