title: Antibody response to bacteriophage hyaluronidase in acute glomerulonephritis after group A streptococcal infection.
abstract: In a test of the hypothesis that lysogeny of group A streptococci by a temperate bacteriophage might confer nephritogenicity, 283 sera from 69 patients were examined for IgG and IgM antibodies to M 49 streptococcal bacteriophage hyaluronidase. The IgG and IgM response to bacteriophage hyaluronidase was greatest in M 49 streptococci-infected individuals with nephritis, but M 49 streptococci-infected subjects without nephritis also had a greater immune response than did subjects infected with serotypes other than M 49. Although antibody to bacterial hyaluronidase was detected in all Streptococcus-infected groups, antibody to M 49 streptococcal bacteriophage hyaluronidase usually was found in only M 49 streptococci-infected patients. Although the greatest IgG and IgM antibody response to bacteriophage hyaluronidase can be demonstrated in individuals with glomerulonephritis, the antibody response does not indicate a direct relation of lysogeny and nephritis because subjects with and without nephritis after M 49 streptococcal infection all had a significant rise in antibody titer.
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis*; D000989:Antistreptolysin / Q000032:analysis; D001435:Bacteriophages / Q000201:enzymology* / Q000276:immunology; D002648:Child; D003851:Deoxyribonucleases / Q000276:immunology; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008242:Lysogeny; D013290:Streptococcal Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000201:enzymology / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D000989:Antistreptolysin; D003851:Deoxyribonucleases; D006821:Hyaluronoglucosaminidase