title: Pyruvate decarboxylase--potentially inactive in the absence of the substrate.
abstract: Using two independent methods, it was shown that pyruvate decarboxylase of brewer's yeast/EC 4.1.1.1./showing a sigmoidal v/S-shape and a corresponding activation phase in the product formation is potentially inactive in the absence of its substrate-pyruvate.
mesh_terms: D002262:Carboxy-Lyases / Q000378:metabolism*; D004789:Enzyme Activation; D007700:Kinetics; D008433:Mathematics; D011485:Protein Binding; D011767:Pyruvate Decarboxylase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology
chemical_list: D002262:Carboxy-Lyases; D011767:Pyruvate Decarboxylase