Moxalactam as single-agent prophylaxis in the prevention of wound infection following colon surgery.
A single agent systemic antibiotic (moxalactam) when used prophylactically in patients undergoing colon surgery was associated with a wound infection rate comparable to that achieved by a combination of oral neomycin and intravenous metronidazole. The data obtained demonstrated that the reduced infection rate was not the result of a reduction in the bacterial content of the colon alone but due to the prophylactic agents used for elective colon surgery.
D000368:Aged; D002986:Clinical Trials as Topic; D003106:Colon / Q000382:microbiology / Q000601:surgery*; D004359:Drug Therapy, Combination; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use; D009070:Moxalactam / Q000627:therapeutic use*; D009355:Neomycin / Q000627:therapeutic use; D011446:Prospective Studies; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*
D008795:Metronidazole; D009355:Neomycin; D009070:Moxalactam