[Use of fibrin glue in tracheal surgery. Experimental studies].
The experimental studies were undertaken in order to estimate the suitability of fibrin sealant in tracheal surgery and the compare tissue reactivity after using cyanoacrylic and fibrin adhesives. 14 piglets of the Poland white breed, weighing up to 25 kg, were used in the study. Under general tracheal anesthesis the tracheal wall was cut open by incision on the mid-line on the neck between the III-IV tubular cartilages along 3/4 of its circumference. The lips of the incision were closed by one atraumatic suture and tightened by fibrin sealant. Piglets dissecting examinations were carried out after 24 hours, 3, 7, 14, 30, 60 and 90 days after the operation. The results were estimated by macro- and microscopic studies. Comparative studies were carried out on the basis of our own similar experimental studies by means of cyanoacrylates. It was found that the Immuno fibrin adhesive is a very useful new material for tightening the tracheal wounds. The Immuno fibrin adhesive, in comparison with cyanoacrylates, has very good biological qualities, does not cause marginal tissue necrosis and increased chronic inflammatory changes. Fibrin sealant undergoes complete elimination from the wound after 7-10 days and is replaced by connective tissue.
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D003487:Cyanoacrylates / Q000494:pharmacology; D005337:Fibrin / Q000494:pharmacology*; D013536:Suture Techniques; D013552:Swine; D014014:Tissue Adhesives / Q000494:pharmacology*; D014132:Trachea / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*
D001672:Biocompatible Materials; D003487:Cyanoacrylates; D014014:Tissue Adhesives; D005337:Fibrin
Zastosowanie kleju fibrynowego w chirurgii tchawicy. Badania doświadczalne.