Congenital cataract with microcornea and Peters' anomaly as expressions of one autosomal dominant gene.
Hereditary congenital cataract is a well recognized but heterogeneous group of disorders; the cataracts may occur alone, or with other ocular or systemic abnormalities, and with all three common modes of inheritance. Peters' anomaly has usually been regarded as a sporadic condition with an insignificant risk of recurrence. A family is described in which congenital cataracts with microcornea, and Peters' anomaly, appear to be variable expressions of a generalized anterior segment disorder inherited as an autosomal dominant condition.
D002386:Cataract / Q000235:genetics* / Q000473:pathology; D002648:Child; D002869:Chromosome Aberrations / Q000235:genetics* / Q000473:pathology; D025063:Chromosome Disorders; D003315:Cornea / Q000002:abnormalities* / Q000473:pathology; D003318:Corneal Opacity / Q000235:genetics* / Q000473:pathology; D016039:Corneal Transplantation; D005786:Gene Expression Regulation; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D010375:Pedigree; D000267:Tissue Adhesions