Bone marrow transplantation in a patient with myelodysplasia associated with diffuse eosinophilic fasciitis.
A 34-year-old man with diffuse eosinophilic fasciitis and a hypocellular myelodysplastic syndrome underwent marrow transplantation from an HLA-identical brother. Prompt hematopoietic reconstitution was observed, strongly suggesting that the marrow hypocellularity was caused by neither a serum inhibitory factor nor a microenvironmental disorder. The patient died of disseminated cytomegalovirus infection too early to evaluate the impact of hematopoietic reconstitution on the eosinophilic fasciitis. Nevertheless, marrow transplantation may offer a therapeutic option for those patients with this disorder who develop severe hematopoietic dysfunction and who have a suitable marrow donor.
D000328:Adult; D016026:Bone Marrow Transplantation; D004802:Eosinophilia / Q000150:complications* / Q000473:pathology / Q000601:surgery; D005190:Family; D005208:Fasciitis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications*; D014019:Tissue Donors
D006680:HLA Antigens