[Neurohormonal factors in congestive heart failure].
Congestive heart failure is characterized by peripheral circulatory abnormalities including arterial and venous vasoconstriction and redistribution of regional blood flow. These peripheral factors are consecutive to a neurohumoral activation of sympathetic, renin-angiotensin-aldosterone and arginine-vasopressin systems. Clinical consequences of these neurohumoral changes are: excessive increase of aortic impedance and myocardial work, salt and water retention a processus which is angiotensin II-dependent, and eventually, hyponatremia. A growing body of evidences suggests that pharmacological blockade of this neurohumoral activation improves clinical and hemodynamic status in patients with congestive heart failure.
D001127:Arginine Vasopressin / Q000502:physiology; D001775:Blood Circulation; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D009490:Neurosecretory Systems / Q000502:physiology*; D012084:Renin-Angiotensin System; D013564:Sympathetic Nervous System / Q000502:physiology
D001127:Arginine Vasopressin
Facteurs neurohormonaux au cours de l'insuffisance cardiaque congestive.