Localization of interleukin-1 in normal or reactive lymphoid tissues and skin: abundance of IL-1 in interdigitating reticulum cells.
The distribution of interleukin 1 producing cells was determined in the human lymphoid tissues and skin using immunohistochemical staining and a rabbit anti-interleukin-1 antibody. Interleukin-1 was detected mainly in the interdigitating reticulum cells localized in the T cell zone. Approximately, 10-30% of the histiocytes were also positively stained by anti-interleukin-1. The results suggests that interdigitating reticulum cells may play an important role in the initiation and amplification of T-cell immunity.
D000818:Animals; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000032:analysis; D003713:Dendritic Cells / Q000032:analysis*; D006644:Histiocytes / Q000032:analysis*; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007375:Interleukin-1 / Q000032:analysis* / Q000276:immunology; D008221:Lymphoid Tissue / Q000032:analysis; D008223:Lymphoma / Q000032:analysis*; D011817:Rabbits; D013601:T-Lymphocytes / Q000032:analysis
D000911:Antibodies, Monoclonal; D007375:Interleukin-1