title: Three-hour volume of distribution method: an accurate simplified method of glomerular filtration rate measurement.
abstract: Eight hundred studies of glomerular filtration rate (GFR) measurements were performed by the standard slope-intercept method using [99mTc]DTPA and results were compared with a simultaneous measurement of the 3-hr tracer volume of distribution. A wide range of human renal function was studied and a nonlinear relationship between GFR and the volume of distribution resulted with an excellent correlation (r = 0.989). Agreement between the two measured parameters was not constant for all levels of renal function with the greatest accuracy being found for GFR = 60 to 100 ml/min.
mesh_terms: D001810:Blood Volume; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D016030:Kidney Transplantation; D008657:Metabolic Clearance Rate; D009942:Organometallic Compounds / Q000378:metabolism; D004369:Pentetic Acid / Q000378:metabolism; D012044:Regression Analysis; D012189:Retrospective Studies; D016284:Technetium Tc 99m Pentetate
chemical_list: D009942:Organometallic Compounds; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate