Severe arthralgias after wide fluctuation in corticosteroid dosage.
A clinical syndrome consisting of severe acute nocturnal knee arthralgias, absent signs of inflammation, and spontaneous resolution in 12 to 72 h was observed in 3 patients in close temporal relationship to wide swings in corticosteroid dosage. A similar clinical picture has previously been described in several renal transplant recipients. With increasing use of pulse corticosteroid treatment for a variety of medical and surgical conditions, this disorder is likely to be encountered in many different settings and deserves recognition because of its dramatic presentation and self-limited course.
D000328:Adult; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000139:chemically induced*; D007719:Knee Joint; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects*; D013577:Syndrome
D011241:Prednisone; D008775:Methylprednisolone