Influence of beta-lactam antibiotics on platelets. I. In vivo effects of latamoxef and related beta-lactam antibiotics on membrane proteins and glycoproteins of rat platelets.
The effects of latamoxef (moxalactam) and the other beta-lactam antibiotics on platelet membrane were studied by intravenous administration of these drugs to rats for 8 d. Blood was taken from the abdominal aorta and washed platelets were prepared by centrifugation. Platelet membrane proteins labeled with 125I and the glycoproteins with 3H were used and analyzed by electrophoresis. Differences of membrane proteins and glycoproteins, compared with the control, were not observed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and two dimensional electrophoresis.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D001797:Blood Protein Electrophoresis / Q000379:methods; D006801:Humans; D008565:Membrane Proteins / Q000097:blood*; D009070:Moxalactam / Q000494:pharmacology; D010980:Platelet Membrane Glycoproteins / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000900:Anti-Bacterial Agents; D008565:Membrane Proteins; D010980:Platelet Membrane Glycoproteins; D009070:Moxalactam