title: Effect of neurotropin (NSP) on the in vivo and in vitro antibody responses in mice.
abstract: Intraperitoneal administration of neurotropin (NSP) did not modify the antibody response to sheep red blood cells (SRBC) in normal BALB/c mice. However, the suppressed antibody responses to SRBC in restraint-stressed mice were favorably restored to normal level by NSP at a dose of 10 or 25 mg/kg either before or even after the stress loading. The suppressed antibody responses in hydrocortisone-treated mice were restored by NSP when it was administered after cortisone. Moreover, NSP augmented the in vitro antibody response to a T cell-dependent antigen, SRBC, but not to T cell-independent antigens such as dinitrophenylated-Ficoll and trinitrophenylated-lipopolysaccharide.
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D005260:Female; D006462:Hemolytic Plaque Technique; D006854:Hydrocortisone / Q000494:pharmacology; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D011134:Polysaccharides / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology; D013312:Stress, Physiological / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D011134:Polysaccharides; C010491:neurotropin; D006854:Hydrocortisone