[Effect of disulfiram on the free amino acid pool of the brain tissue of rats].
Disulfiram (DS) (200 mg/kg for 3 days) decreases contents of GABA, phenylalanine, histidine, cystathionine, methionine, ornithine, leucine and lysine. The effect of DS is potentiated by ethanol (1 g/kg). In this case concentrations of alanine, valine, isoleucine and tyrosine additionally fall. Probable roles of GABA-ergic system and amino acids--precursors, neurotransmitters in the realization of therapeutic and, perhaps, side effects of DS are discussed. Additive effects of DS and its combination with ethanol indicates a significant contribution of acetaldehyde to the mentioned changes.
D000079:Acetaldehyde / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D004221:Disulfiram / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology; D008297:Male; D051381:Rats
D000596:Amino Acids; D000431:Ethanol; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde; D004221:Disulfiram
Vliianie disul'firama na fond svobodnykh aminokislot tkani golovnogo mozga krys.