title: The effect of buflomedilhydrochloride (Loftyl) on temporary hearing threshold shift.
abstract: Buflomedilhydrochloride (Loftyl, Abbott) is a vasodilating agent which has proved not only to influence peripheral blood vessels but also cerebral vascular disease. We tested the ability of Buflomedil to prevent noise-induced temporary threshold shift (TTS). Ten individuals tested the active substance and placebo 5 times each at random. In the individual analysis comparing Buflomedil and placebo sessions, there was a statistically significant decreased TTS after Buflomedil.
mesh_terms: D000328:Adult; D001305:Auditory Fatigue / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D011674:Pulse / Q000187:drug effects; D011759:Pyrrolidines / Q000494:pharmacology*; D011897:Random Allocation; D012044:Regression Analysis; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D011759:Pyrrolidines; D014665:Vasodilator Agents; C010651:buflomedil