Fibroblast growth factor enhances the interleukin-1-mediated chondrocytic protease release.
The unfractionated macrophage-conditioned medium stimulates the chondrocytes to produce high levels of proteases. Purified IL-1 preparations exhibit significantly lower activity towards chondrocytes. This IL-1 mediated effect can be enhanced in presence of fibroblast growth factor, suggesting that other factors may collaborate with IL-1, in events leading to the cartilage destruction in vivo.
D000818:Animals; D002356:Cartilage / Q000187:drug effects* / Q000201:enzymology; D002478:Cells, Cultured; D003470:Culture Media; D004357:Drug Synergism; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D006801:Humans; D007375:Interleukin-1; D008264:Macrophages / Q000032:analysis; D010447:Peptide Hydrolases / Q000378:metabolism*; D011817:Rabbits
D003470:Culture Media; D007375:Interleukin-1; D005346:Fibroblast Growth Factors; D010447:Peptide Hydrolases