Reversibility of graft rejection following a short cyclosporin-A administration 5 days after grafting.
The aim of this research was to investigate whether cyclosporin-A (Cy-A) could exert its action on graft rejection in progress. For this purpose, heart-lung grafting was performed in a strong histoincompatible combination of rats (BN/LEW). In one group of animals, Cy-A was administered at the dose of 15 mg/kg daily for 10 days starting on the 5th day after grafting. In a control group only olive oil was administered. Five of six animals treated with Cy-A showed a graft survival over 4 weeks and in two cases it was over 2 months when they were killed.
D000818:Animals; D003524:Cyclosporins / Q000627:therapeutic use*; D006084:Graft Rejection / Q000187:drug effects*; D006085:Graft Survival / Q000187:drug effects; D016027:Heart Transplantation; D016040:Lung Transplantation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003524:Cyclosporins