title: [Methods of enhancing the radioprotective efficacy of serum immunoglobulin].
abstract: In this work the authors propose three ways of increasing the radioprotective efficiency of immunoglobulin: in vitro irradiation with gamma-quanta (60Co, 20,000 Gy), increasing the time of storage of whole blood (raw material for immunoglobulin production) up to 5-7 days at +4 degrees C, and the application of immunoglobulin with antibiotics. In experiments in vitro it was first shown that a combination of immunoglobulin with gentamicin exerted a pronounced bactericidal effect on E. coli. The effect was absent with immunoglobulin and markedly less pronounced with gentamicin used separately.
mesh_terms: D000818:Animals; D001793:Blood Preservation; D005260:Female; D005720:Gamma Rays; D005839:Gentamicins / Q000627:therapeutic use; D007116:Immunization, Passive / Q000379:methods*; D007136:Immunoglobulins / Q000528:radiation effects*; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000628:therapy*; D014916:Whole-Body Irradiation
chemical_list: D005839:Gentamicins; D007136:Immunoglobulins
vernacular_title: Nekotorye sposoby povysheniia protivoluchevoĭ éffektivnosti immunoglobulina krovi.