Rational acyclovir therapy in herpetic eye disease.
Acyclovir has been widely used against the various manifestations of eye disease due to herpes simplex since it first became generally available in the UK nearly five years ago. This paper discusses the rational indications for its use, through considerations of its pharmacology and pharmacokinetics, and through results of the many clinical trials that have been carried out to investigate its effects since its clinical efficacy was first demonstrated in 1979.
D000212:Acyclovir / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003236:Conjunctivitis, Viral / Q000188:drug therapy; D003320:Corneal Ulcer / Q000188:drug therapy; D006561:Herpes Simplex / Q000188:drug therapy; D006801:Humans; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D014605:Uveitis / Q000188:drug therapy
D000212:Acyclovir