Uptake of platinum compounds in human tumors. In vitro study.
The kinetics of intratumoral uptake of cisplatin, carboplatin (CBDCA) and TNO-6 were studied in vitro in fragments of tumors of the head and neck maintained in culture medium under conditions simulating therapeutic conditions of chemo-embolization. Cisplatin and TNO-6 are more rapidly taken up than CBDCA (carboplatin). With each of these compounds, after 24 hours a fraction of the platinum taken up is not irreversibly bound to the tissue. The rate of uptake and the proportion of platinum irreversibly bound depends a great deal on the tumor under study. The characteristics of the diffusion indicate that TNO-6 is better used with chemo-embolization than with systemic injection. The opposite finding is seen with carboplatin. Cisplatin appears to to be about equally well-suited for either method of injection.
D000368:Aged; D000970:Antineoplastic Agents / Q000378:metabolism; D016190:Carboplatin; D002478:Cells, Cultured; D002945:Cisplatin / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism*; D009944:Organoplatinum Compounds / Q000378:metabolism; D010610:Pharyngeal Neoplasms / Q000378:metabolism*; D010984:Platinum / Q000378:metabolism*; D013997:Time Factors
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D010984:Platinum; D016190:Carboplatin; C040757:spiroplatin; D002945:Cisplatin