Skin graft and kidney transplantation in rats. Relation between circulatory condition of the transplanted organ and histocompatibility.
To determine the relationship between histocompatibility and circulation in the transplanted graft, which are the major factors influencing graft survival, the survival of the skin grafts and kidney transplants were compared between strong (ACI to Lewis) and weak (Fisher to Lewis) histocompatible strains, because rats given skin graft receive poor blood supply from a recipient, and the rats given kidney transplants receive immediate blood supply after transplant. In the group with a weak histocompatibility barrier circulation of the engrafted organ was better and the survival period longer. In the group with a strong histocompatibility barrier graft survival was little influenced by the circulatory disorder, and the degree of histocompatibility overwhelmed the circulatory condition.
D000818:Animals; D006084:Graft Rejection; D006648:Histocompatibility; D007668:Kidney / Q000098:blood supply; D016030:Kidney Transplantation; D008297:Male; D051381:Rats; D011912:Rats, Inbred ACI; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D012079:Renal Circulation; D012867:Skin / Q000098:blood supply; D016038:Skin Transplantation