Serotonin and norepinephrine content in brain structures of rats with experimental and transplantation-compensated diabetes.
The development of alloxan-induced diabetes in rats is shown to be accompanied by a decrease in the norepinephrine (NE) and serotonin (5-OT) content in the neocortex and caudal segment of the brain stem. Simultaneously the intensity of 3H-leucine labelling of the brain tissue was decreased. The attempt to compensate the diabetic syndrome in rats by transplanting the embryonic pancreas (EP) into the anterior chamber of the eye (ACE) was successful. All the animals with the adapted transplant showed a return of the monoamine level to the normal, a decrease in urine glucose, as well as normalization of protein synthesis by the 14th-20th days.
D000496:Alloxan; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000628:therapy; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D016035:Pancreas Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D000496:Alloxan; D009638:Norepinephrine