title: Hydrocephalus: increased intracranial pressure and brain stem auditory evoked responses in the hydrocephalic rabbit.
abstract: The auditory evoked response (AER) was used to study the effect of increased intracranial pressure (ICP) on the auditory pathway in normal New Zealand rabbits and in those made hydrocephalic by intracisternal injections of kaolin. AERs were studied: (a) in the normal and then in the hydrocephalic animal; and (b) in the hydrocephalic animal during further ICP elevation by cerebrospinal fluid infusion. The AER was obtained from ongoing electroencephalographic activity after rarefaction auditory clicks presented at 90 dB sound pressure equivalent. In comparing base line normal AERs to those found in hydrocephalic conditions, a statistically significant increase in latency for AER components N2, P2, and P5 was noted in hydrocephalic rabbits. Increased ICP in the hydrocephalic model showed an increase in the latencies of AER components for P0 and P1 at 250 mm H2O, and a prolongation of P3-P5 central conduction time at 700 mm H2O above base line cerebrospinal fluid pressure. In addition, a decrease in the P4/N5 amplitude and an increase in P1-P3 central conduction times at 700 mm H2O was observed. The differences between normal and hydrocephalic rabbit AER base lines may be the result of the chronically increased ICP and presumed chronic anatomical changes within the auditory pathway due to kaolin itself. The differences in the AER from base line hydrocephalus to acute increased ICP may indicate that the hydrocephalic system is more sensitive to acute neuropraxic pressure effects on the brain stem auditory structures than is the normal brain.
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D001933:Brain Stem / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory; D006849:Hydrocephalus / Q000473:pathology / Q000503:physiopathology*; D007427:Intracranial Pressure; D011817:Rabbits; D012016:Reference Values