Urinary tract infection after vaginal surgery. Effect of prophylactic treatment with methenamine hippurate.
One hundred and nine consecutive patients undergoing surgery for uterovaginal prolapse followed by indwelling urinary catheter for 3 days were randomized for prophylactic treatment with methenamine hippurate (MH) or no MH prophylaxis. Significantly less bacteriuria occurred in the MH-treated patient group. In particular, the opportunistic hospital flora appeared to be suppressed by MH treatment. It is suggested that MH prophylaxis, 1 g three times daily, be used in gynecological surgery followed by short-term urinary catheterization.
D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use*; D002408:Catheters, Indwelling; D002986:Clinical Trials as Topic; D005260:Female; D006626:Hippurates / Q000627:therapeutic use*; D006801:Humans; D008709:Methenamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D011897:Random Allocation; D014552:Urinary Tract Infections / Q000517:prevention & control*; D014596:Uterine Prolapse / Q000601:surgery; D014621:Vagina / Q000601:surgery*
D000892:Anti-Infective Agents, Urinary; D006626:Hippurates; D008709:Methenamine; C011481:methenamine hippurate