title: Therapeutic concentrations of griseofulvin do not affect yeast cell phagocytosis by monocytes.
abstract: The effect of griseofulvin on monocyte phagocytosis was assessed by studying the uptake of fluorescent yeast cells by glass-adherent monocytes (a fluorescence-quenching technique). In contrast to other microtubule antagonists, griseofulvin did not inhibit monocyte phagocytosis. It is suggested that the lack of griseofulvin interference with essential leukocyte functions is a possible explanation for the fact that the microtubule antagonist griseofulvin serves as a comparatively safe and harmless drug.
mesh_terms: D000268:Adhesiveness; D000328:Adult; D003470:Culture Media; D005260:Female; D005898:Glass; D006118:Griseofulvin / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000276:immunology*
chemical_list: D003470:Culture Media; D006118:Griseofulvin