Effect of housing in an enriched environment on the size of the cerebral cortex in young and old rats.
To assess whether or not environmental changes may continue to affect measures relating to cortical size, the size of the cerebral cortex of young adult (7 to 8 months) and old (32 to 33 months) "standard" and "enriched" rats were compared. Enriched rats were housed in large cages during 10 weeks and had access to many different objects; age-matched controls remained in standard laboratory cages. Effects on the cerebral cortex were small; a significant increase in cortical thickness at one, albeit different, site in both age groups was observed. Significant correlations were not present between environmentally induced changes in sleep parameters (recorded in the same rats prior to the present experiment) and the small change in cortical size. The results do, however, support the hypothesis that a certain amount of plasticity of the cerebral cortex is preserved in old age.
D000367:Age Factors; D000818:Animals; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D004777:Environment; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN