[Functional changes in the state of the insular system of animals after intravenous administration of diabetogenic factor].
Natural diabetogenic factor, which is albumin with molecular mass 60,000 Da, occurring in blood plasma of rats impaired with alloxan diabetes, caused a stable hyperglycemia, distinct decrease of insulin in blood and increased the body resistance to insulin in healthy animals. Activity of the diabetogenic factor was neutralized by heparin.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000503:physiopathology*; D006493:Heparin / Q000097:blood; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood* / Q000494:pharmacology; D007333:Insulin Resistance; D008297:Male; D010907:Pituitary Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D001786:Blood Glucose; C488867:DGF protein, rat; D007328:Insulin; D010907:Pituitary Hormones; D006493:Heparin
Funktsional'nye izmeneniia v sostoianii insuliarnoĭ sistemy u zhivotnykh posle vnutrivennogo vvedeniia diabetogennogo faktora.