title: A cytosolic protein contains a cryptic mitochondrial targeting signal.
abstract: Cytosolic dihydrofolate reductase from mouse contains a cryptic mitochondrial targeting sequence. If this sequence is attached to the amino terminus of 'passenger' proteins which by themselves cannot enter mitochondria, the resulting fusion proteins are transported into yeast mitochondria.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport; D002645:Chickens / Q000235:genetics; D003600:Cytosol / Q000201:enzymology; D051379:Mice / Q000235:genetics; D008928:Mitochondria / Q000378:metabolism*; D011487:Protein Conformation; D011993:Recombinant Fusion Proteins / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics* / Q000378:metabolism
chemical_list: D011993:Recombinant Fusion Proteins; D011994:Recombinant Proteins; D013762:Tetrahydrofolate Dehydrogenase