[Alcohol and hypertension in sudden cardiac death, features of the status of the renin-angiotensin-aldosterone system].
The activity of blood plasma renin and the renal cortical layer in persons who had suddenly died, was much lower in those with arterial hypertension than in those without it. A more pronounced increase in the activity of blood plasma renin and the renal cortex was noted in persons with hypertension who had died against a background of alcoholic intoxication as compared to persons without hypertension. In sudden cardiac death of persons without hypertension there was a positive correlation between plasma renin activity and alcohol concentration in the blood. Such a correlation was undetectable in the presence of hypertension. In small alcohol concentrations in the blood higher plasma renin activity values were noted in persons with hypertension than in those without it. Aldosterone concentration in the blood of patients with arterial hypertension and without it did not practically differ. The presence of alcohol in persons without hypertension resulted in a significant increase in aldosterone concentration in sudden cardiac death as compared to those with hypertension. A positive correlation between renin activity and aldosterone concentration was noted in all the groups under study.
D000328:Adult; D000435:Alcoholic Intoxication / Q000150:complications*; D003645:Death, Sudden / Q000209:etiology*; D006323:Heart Arrest / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012084:Renin-Angiotensin System
Alkogol' i gipertoniia pri vnezapnoĭ serdechnoĭ smerti, osobennosti sostoianiia renin-angiotenzin-al'dosteronovoĭ sistemy.