Allium sativum (garlic) inhibits lipid synthesis by Candida albicans.
The effect of aqueous garlic extract on the macromolecular synthesis of Candida albicans was studied. Protein and nucleic acid syntheses were inhibited to the same extent as growth, but lipid synthesis was completely arrested. Blockage of lipid synthesis is likely an important component of the anticandidal activity of garlic.
D002176:Candida albicans / Q000187:drug effects / Q000378:metabolism*; D005737:Garlic / Q000032:analysis*; D008055:Lipids / Q000096:biosynthesis*; D009696:Nucleic Acids / Q000096:biosynthesis; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal
D008055:Lipids; D009696:Nucleic Acids; D010936:Plant Extracts