Oligonucleotide synthesis on a cellulose acetate functionalized with a spacer.
4-(2-Hydroxyethylsulfonyl)dihydrocinnamate derivative of cellulose acetate (D.S. 1.77) was used for polymer support synthesis of oligonucleotides bearing a phosphodiester function at the 3'-terminal position, taking into consideration that the cellulose derivative is readily soluble in pyridine, but slightly soluble in a solvent such as ethanol.
D002482:Cellulose / Q000031:analogs & derivatives; D007202:Indicators and Reagents; D009841:Oligonucleotides / Q000138:chemical synthesis*; D012995:Solubility
D007202:Indicators and Reagents; D009841:Oligonucleotides; C005062:acetylcellulose; D002482:Cellulose