Metabolic disposition of piperine in the rat.
After oral administration of piperine (170 mg/kg) to rats, the metabolites in bile and urine were examined by thin-layer chromatography, high-performance liquid chromatography and combined gas chromatography-mass spectrometry. Four metabolites of piperine, viz. piperonylic acid, piperonyl alcohol, piperonal and vanillic acid were identified in the free form in 0-96 h urine whereas only piperic acid was detected in 0-6 h bile. Based on these results, a pathway for the biotransformation of piperine in rats is proposed.
D000470:Alkaloids; D000818:Animals; D052117:Benzodioxoles; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D008297:Male; D010880:Piperidines / Q000378:metabolism*; D053284:Polyunsaturated Alkamides; D051381:Rats; D011919:Rats, Inbred Strains; D012451:Safrole / Q000378:metabolism
D000470:Alkaloids; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D012451:Safrole; C008922:piperine