title: [Comparative in-flight study of a scopolamine-containing membrane plaster versus dimenhydrinate under defined acceleration conditions].
abstract: The efficacy and tolerability of Scopoderm TTS (SCOTTS), a transdermal system containing scopolamine, were compared with those of the oral antiemetic dimenhydrinate (double-dummy technique) in a controlled, double-blind, within-patient study including 20 test persons with proven motion sickness. During a 1-h test flight, SCOTTS proved to be as effective as dimenhydrinate. The efficacy and tolerability of both SCOTTS and dimenhydrinate were assessed as to be equally good. Due to its galenic properties, SCOTTS is effective over a 72-h period and therefore is useful in the prevention of motion sickness during long-distance flights, where it is superior to dimenhydrinate.
mesh_terms: D000054:Acceleration; D000279:Administration, Cutaneous; D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004111:Dimenhydrinate / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005079:Excipients; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009041:Motion Sickness / Q000188:drug therapy*; D012601:Scopolamine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000932:Antiemetics; D005079:Excipients; D012601:Scopolamine; D004111:Dimenhydrinate
vernacular_title: Vergleichende Inflight-Untersuchung eines Scopolamin-haltigen Membranpflasters versus Dimenhydrinat unter definierten Beschleunigungsreizen.