Growth failure associated with medullary sponge kidney, due to incomplete renal tubular acidosis type 1.
A girl, 12 years of age, was referred for short stature. Clinical examination and laboratory investigations currently performed in a case of growth failure gave normal results. Renal echography revealed a hyper-echogenic renal medulla. An excretory urogram showed medullary sponge kidney with bilateral renal calculi. An ammonium chloride loading test revealed a defect in acid excretion and led to the diagnosis of incomplete renal tubular acidosis. Treatment with oral bicarbonate was associated with an increase in growth velocity.
D000141:Acidosis, Renal Tubular / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D001639:Bicarbonates / Q000627:therapeutic use; D002648:Child; D005260:Female; D006130:Growth Disorders / Q000209:etiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007669:Kidney Calculi / Q000150:complications / Q000175:diagnosis; D007691:Medullary Sponge Kidney / Q000150:complications* / Q000175:diagnosis; D009397:Nephrocalcinosis / Q000150:complications / Q000175:diagnosis; D014463:Ultrasonography; D014556:Urine
D001639:Bicarbonates