[Experimental and clinical evaluation of the biliary elimination of ceftazidime].
After adding 10 mg of ceftazidime to the circulating blood of five isolated rabbit liver perfusions, total antibiotic excretion over a 3 hours period accounted for 1.4% of the administered dose; only 0.9% was found to be metabolized by the liver. In five healthy subjects given 2 g ceftazidime intravenously, 0.05% (102 +/- 576 micrograms) was recovered in the duodenal fluid over a four-hour period. In 10 patients with a T-tube inserted following cholecystectomy, 0.21% of a 2 g dose of ceftazidime injected intravenously was found in the bile collected over a 12-hour period (4 161 +/- 489 micrograms); a mean biliary peak of 36.3 +/- 4.0 micrograms/ml was recorded during the second hour. In 10 patients in whom serum, choledochal bile and gallbladder bile were sampled simultaneously during surgery 1 hour after IV administration of ceftazidime, the concentrations found were 40.6/e 2.1, 78.3 +/- 12.0 and 17.9 +/- 7.5 micrograms/ml respectively. Our results suggests that ceftazidime may be suitable in the treatment of biliary tract infections.
D000328:Adult; D000818:Animals; D001646:Bile / Q000378:metabolism*; D002442:Ceftazidime / Q000378:metabolism* / Q000627:therapeutic use; D002764:Cholecystitis / Q000188:drug therapy; D003135:Common Bile Duct / Q000378:metabolism; D004386:Duodenum / Q000378:metabolism; D005260:Female; D005704:Gallbladder / Q000378:metabolism; D006801:Humans; D007419:Intestinal Secretions / Q000032:analysis; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D011817:Rabbits
D002442:Ceftazidime
Evaluation expérimentale et clinique de l'élimination biliaire de la ceftazidime.