Immunoperoxidase confirmation of parathyroid origin of ultrasound-guided fine needle aspirates of the parathyroid glands.
It may be difficult to differentiate between cells of parathyroid and thyroid origin in ultrasound-guided fine needle aspirations of the neck region, even in patients with a clinical history of hyperparathyroidism. A parathyroid hormone antibody was used in an immunohistochemical system to confirm a parathyroid origin in fine needle aspirate smears from nine patients with hyperparathyroidism. Immunoperoxidase positivity for parathyroid hormone confirmed a parathyroid origin in six of nine cases and was strongly suggestive, although equivocal, in the remaining three cases. Technical problems included nonuniform staining and background staining.
D000236:Adenoma / Q000473:pathology; D001707:Biopsy, Needle / Q000379:methods; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis* / Q000473:pathology; D006965:Hyperplasia; D007124:Immunoenzyme Techniques; D010279:Parathyroid Diseases / Q000175:diagnosis* / Q000473:pathology; D010281:Parathyroid Hormone / Q000032:analysis; D014463:Ultrasonography
D010281:Parathyroid Hormone