Lymphatics in the aorta of rats treated with a soy-bean oil extract (lipofundin).
Lipofundin-S 20% (a soy-bean oil extract) when administered intravenously to rats resulted in dilation of aortic lymphatics at the media-adventitia junction. Increased endothelial permeability as demonstrated by intraaortic colloidal iron uptake with dynamic insufficiency of lymphatic drainage is suggested as the basis for dilatation of intraaortic adventitial lymphatics.
D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000473:pathology; D004108:Dilatation, Pathologic / Q000139:chemically induced; D004338:Drug Combinations / Q000633:toxicity; D004727:Endothelium / Q000473:pathology; D005990:Glycerol / Q000633:toxicity*; D008208:Lymphatic System / Q000187:drug effects* / Q000473:pathology; D008854:Microscopy, Electron; D010539:Permeability; D010743:Phospholipids / Q000633:toxicity*; D010938:Plant Oils / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013024:Soybean Oil / Q000633:toxicity*
D004338:Drug Combinations; D010743:Phospholipids; D010938:Plant Oils; C046535:Lipofundin S; D013024:Soybean Oil; D005990:Glycerol