Corneal allograft rejection in rabbits.
We performed a phase I study to assess the therapeutic efficacy of an anti-T cell monoclonal antibody conjugated with ricin A-chain in a corneal graft rejection model. Corneal allografts were exchanged between Dutch and New Zealand rabbits. Rejections occurred within 16-22 days in untreated animals. Graft rejection was delayed by topical or retrobulbar cyclosporine, but not by subconjunctival injections of a murine anti-rabbit T cell monoclonal antibody, nor by either subconjunctival or intravenous F(ab')2-ricin conjugate.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D016039:Corneal Transplantation; D003524:Cyclosporins / Q000627:therapeutic use; D006084:Graft Rejection / Q000187:drug effects; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use; D011817:Rabbits; D012276:Ricin / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D003524:Cyclosporins; D007140:Immunoglobulin Fab Fragments; D012276:Ricin