Rigidity in rats due to radio frequency decerebration and effects of chlorpromazine and mephenesin.
Bilateral radio frequency (RF) lesions of the midbrain were produced in an attempt to establish a non-bleeding method of producing decerebrate rigidity in rats. Marked extensor rigidity occurred with a high reproducibility in hindlimbs without the appearance of voluntary movement. Stretch reflex tension induced by repetitive dorsiflexion of the hindfeet was employed as a measure of the intensity of rigidity. Chlorpromazine-HCl (0.1-1 mg/kg, i.v.) and mephenesin (10-50 mg/kg, i.v.) which depress intercollicular decerebrate rigidity, reduced the RF decerebrate rigidity. These results suggest that RF decerebrate rigidity can be used instead of intercollicular transection rigidity in the pharmacological and physiological studies.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D003655:Decerebrate State / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008615:Mephenesin / Q000494:pharmacology*; D009127:Muscle Rigidity / Q000209:etiology / Q000503:physiopathology*; D011846:Radio Waves; D051381:Rats; D011919:Rats, Inbred Strains; D012026:Reflex, Stretch / Q000187:drug effects
D008615:Mephenesin; D002746:Chlorpromazine