[Thrombocyte sensitivity to prostacyclin in myocardial infarct complicated by acute left ventricular failure].
A study of platelet aggregation and platelet sensitivity to prostacyclin in 82 patients with acute myocardial infarction demonstrated a relationship between clinical pattern of the disease and platelet hemostasis. Platelet functional activity was the highest by the end of week 2 in uncomplicated myocardial infarction. In cases where myocardial infarction was complicated by acute left-ventricular insufficiency, platelet function differed depending on the severity and outcome of the complication. Some patients with pulmonary edema showed protracted low-grade, yet irreversible, two-wave platelet aggregation. Platelet sensitivity was significantly lower in pulmonary edema, as compared to cardiac asthma, while the lowest sensitivity was associated with terminal pulmonary edema.
D000208:Acute Disease; D001792:Blood Platelets / Q000502:physiology*; D011464:Epoprostenol; D006333:Heart Failure / Q000097:blood* / Q000209:etiology; D006352:Heart Ventricles; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications; D010974:Platelet Aggregation; D011654:Pulmonary Edema / Q000209:etiology
D011464:Epoprostenol
Chuvstvitel'nost' trombotsitov k prostatsiklinu pri infarkte miokarda, oslozhnennom ostroĭ levozheludochkovoĭ nedostatochnost'iu.