Therapeutic concentrations of griseofulvin do not affect yeast cell phagocytosis by monocytes.
The effect of griseofulvin on monocyte phagocytosis was assessed by studying the uptake of fluorescent yeast cells by glass-adherent monocytes (a fluorescence-quenching technique). In contrast to other microtubule antagonists, griseofulvin did not inhibit monocyte phagocytosis. It is suggested that the lack of griseofulvin interference with essential leukocyte functions is a possible explanation for the fact that the microtubule antagonist griseofulvin serves as a comparatively safe and harmless drug.
D000268:Adhesiveness; D000328:Adult; D003470:Culture Media; D005260:Female; D005898:Glass; D006118:Griseofulvin / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000276:immunology*
D003470:Culture Media; D006118:Griseofulvin