Oxidation of ethanol to acetaldehyde by bronchopulmonary washings: role of bacteria.
The synergistic effects of tobacco smoking and alcohol consumption on the incidence of upper respiratory cancer may be linked to their common ability to produce acetaldehyde, an irritant and potential mutagen. Since alcohol consumption in most individuals results in very low concentrations of acetaldehyde in the blood, we determined whether bronchopulmonary cellular components are capable of oxidizing ethanol to acetaldehyde. We found that significant production of acetaldehyde occurred in vitro after incubation of human bronchopulmonary washings with 25 mM ethanol. Acetaldehyde production was increased in active smokers and related to microorganisms in the bronchopulmonary tract. It was abolished by preincubation of the washings with antibiotics and was reproduced in vitro with Streptococcus pneumoniae. Normal pulmonary cells in bronchopulmonary washings did not produce acetaldehyde from ethanol.
D000079:Acetaldehyde / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D001419:Bacteria / Q000378:metabolism*; D001980:Bronchi / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism*; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D011650:Pulmonary Alveoli / Q000378:metabolism; D012907:Smoking
D000431:Ethanol; D000079:Acetaldehyde