[Evaluation of the efficacy of verapamil and nifedipine as long-term crossover therapy with individually selected doses in ischemic heart disease. Work Group for the Cooperative Study of Antianginal Preparations (SCAP)].
Paired bicycle ergometric tests are an adequate means for the selection of an antianginal agent to be used on a long-term basis in anginal patients. It allows to choose the most effective type of antianginal medication out of three major groups (the nitrates, calcium antagonists and beta-adrenoblockers) and determine the dose and regimen of administration that would be optimum for an individual patient. Teh efficiency of verapamil and nifedipine was similar during long-term treatment with individually-selected doses in those cases where calcium antagonists were found to be preferable. Administration regimens of the two drugs were, however, somewhat different.
D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy*; D003327:Coronary Disease / Q000503:physiopathology; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage / Q000627:therapeutic use*
D014700:Verapamil; D009543:Nifedipine
Otsenka éffektivnosti verapamila i nifedipina pri dlitel'nom perekrestnom primenenii v individual'no podobrannykh dozakh u bol'nykh ishemicheskoĭ bolezn'iu serdtsa. Radochaia gruppa kooperativnogo issledovaniia antianginal'nykh preparatov (KIAP).