Functional effects of splenin32-34 on antibody formation in immunosuppressed mice.
Sublethally irradiated AB/Bln mice (500 cGy) were treated with splenotritin (fragment 32-34 of the splenic hormone splenin) and tested for their capability of producing antibodies against target sheep red blood cells. In x-ray plus splenotritin treated mice antibody forming cells were found earlier and in a higher frequency than in mice treated with x-rays alone.
D000276:Adjuvants, Immunologic / Q000502:physiology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects* / Q000528:radiation effects; D004912:Erythrocytes / Q000276:immunology; D007108:Immune Tolerance; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000528:radiation effects; D010446:Peptide Fragments / Q000276:immunology / Q000502:physiology*; D012756:Sheep / Q000097:blood; D016305:Thymopentin; D013946:Thymopoietins / Q000276:immunology / Q000502:physiology*; D013951:Thymus Hormones / Q000502:physiology*; D014916:Whole-Body Irradiation
D000276:Adjuvants, Immunologic; D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; C051920:splenotritin; D016305:Thymopentin