title: Reactivity of essential histidine residues in EF-Tu.GDP and EF-Tu.GTP from Escherichia coli.
abstract: The microenvironment of histidine residues located in the binding site of elongation factor EF-Tu from Escherichia coli for the 3' terminus of aminoacyl-tRNA is altered during transition of EF-Tu.GDP to EF-Tu.GTP.
mesh_terms: D001665:Binding Sites; D004926:Escherichia coli / Q000378:metabolism*; D006150:Guanine Nucleotides / Q000378:metabolism*; D006153:Guanosine Diphosphate / Q000378:metabolism*; D006160:Guanosine Triphosphate / Q000378:metabolism*; D006639:Histidine / Q000378:metabolism*; D010444:Peptide Elongation Factor Tu / Q000378:metabolism*; D011487:Protein Conformation; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D006150:Guanine Nucleotides; D012346:RNA, Transfer, Amino Acyl; D006153:Guanosine Diphosphate; D006639:Histidine; D006160:Guanosine Triphosphate; D010444:Peptide Elongation Factor Tu