title: [Purification of a corpuscular influenza vaccine by means of immunoaffinity chromatography].
abstract: Two immunoaffinity chromatographic methods for the purification of corpuscular influenza vaccine from the admixture of chick embryo components have been examined. The isolation of the virus on immobilized antiviral antibodies has proved to be unsuitable for preparative purposes. The method for the purification of the vaccine from ovalbumin with the use of immobilized anti-ovalbumin antibodies has proved to be highly effective. When introduced into guinea pigs in 3 injections, the vaccine purified by immunosorption has been found to produce no anaphylactic reactions.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000302:isolation & purification; D002645:Chickens; D002846:Chromatography, Affinity / Q000379:methods; D007106:Immune Sera / Q000302:isolation & purification; D007114:Immunization / Q000379:methods; D007163:Immunosorbent Techniques; D007252:Influenza Vaccines / Q000302:isolation & purification*; D010047:Ovalbumin / Q000276:immunology / Q000302:isolation & purification; D012756:Sheep
chemical_list: D000956:Antigens, Viral; D007106:Immune Sera; D007252:Influenza Vaccines; D010047:Ovalbumin
vernacular_title: Ochistka korpuskuliarnoĭ grippoznoĭ vaktsiny metodami immunoaffinnoĭ khromatografii.