ECG changes during haloperidol and pimozide treatment of Tourette's disorder.
The ECG QTc interval was significantly prolonged by pimozide but not haloperidol or placebo in a randomized clinical trial with 40 patients with Tourette's disorder. However, no adverse cardiac effects or differences in rate, rhythm, or waveform were found.
D000328:Adult; D002986:Clinical Trials as Topic; D004562:Electrocardiography; D005260:Female; D006220:Haloperidol / Q000494:pharmacology / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010868:Pimozide / Q000494:pharmacology / Q000627:therapeutic use*; D010919:Placebos; D011897:Random Allocation; D005879:Tourette Syndrome / Q000188:drug therapy*
D010919:Placebos; D010868:Pimozide; D006220:Haloperidol