Insulin-like effect of dichloroacetic acid on hexose transport in Swiss 3T3 cells.
Hexose transport in Swiss 3T3 cells was increased by treatment with dichloroacetic acid as well as by treatment with insulin. Neither extra- nor intracellular Ca2+ was found to be involved in their stimulatory action. On the other hand, the removal of intracellular Mg2+ resulted in a loss of the stimulation. These results suggest that dichloroacetic acid stimulates the hexose transport in Mg2+-dependent manner, similar to that of insulin.
D019325:3-O-Methylglucose; D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology; D002460:Cell Line; D003999:Dichloroacetic Acid / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D006601:Hexoses / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology; D008757:Methylglucosides / Q000378:metabolism; D051379:Mice
D000085:Acetates; D006601:Hexoses; D007328:Insulin; D008757:Methylglucosides; D019325:3-O-Methylglucose; D003999:Dichloroacetic Acid; D008274:Magnesium; D005947:Glucose; D002118:Calcium