title: [Genetic analysis of mitochondrial rho-mutability in Saccharomyces. III. Comparative analysis of the effect of various nuclear srm mutations and disomy for chromosome IV on rho-mutagenesis].
abstract: Different combinations of modifying genes which enhance the rho- mutability of haploid yeast cells are shown to be suppressible by the srm1, srm2, srm3 mutations and by the disomy for chromosome IV. The srm1 mutation leads to dramatic decrease in both the spontaneous and ethidium-bromide induced rho- mutability. Other srm mutations studied and the disomy appear to cause relatively moderate quantitative changes in the spontaneous rho- mutation rate and to have no significant effect on mutation induction by ethidium bromide. Neither additivity nor synergism was revealed by the analysis of the interaction between the srm mutations. We suggest that in Saccharomyces an efficient mechanism of the rho- mutagenesis operates which can be directly affected by the srm1 mutation and more or less modified by other srm mutations under study and by the disomy for chromosome IV.
mesh_terms: D004271:DNA, Fungal / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D005800:Genes, Fungal; D005809:Genes, Regulator; D009154:Mutation; D012234:Rho Factor / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004271:DNA, Fungal; D004272:DNA, Mitochondrial; D012234:Rho Factor; D014157:Transcription Factors
vernacular_title: Geneticheskiĭ analiz mitokhondrial'noĭ rho-mutabil'nosti drozhzheĭ sakharomitsetov. Soobshchenie III. Sravnitel'nyĭ analiz vliianiia razlichnykh iadernykh mutatsiĭ srm i disomii po khromosome IV na rho-mutagenez.