[Diffusion of ceftriaxone in human bone tissue].
Ceftriaxone diffusion into spongious and cortical bone after single 2 g dose by intravenous injection was studied in 40 patients undergoing total hip replacement. Serum and tissue assays were performed by HPLC and microbiological method 2, 4, 12 and 24 hours after administration. Both methods produced similar results. Antibiotic levels (HPLC) were 19.3 +/- 7.3; 16.9 +/- 9.2; 11.2 +/- 4.7 and 5.6 +/- 2.7 micrograms/g in spongious bone at hours 2, 4, 12 and 24, and 6.5 +/- 1.6; 3.1 +/- 0.7; 3.3 +/- 1.1 and 2.2 +/- 0.4 micrograms/g in cortical bone at the same times. The tissue/serum ratios were 14% for spongious bone and 5% for cortical bone after 2 hours. At hour 24 these ratios were 21% and 8% in spongious and cortical bone respectively. These tissue levels remain higher than ceftriaxone MIC for most Enterobacteriaceae strains until hour 24.
D000368:Aged; D001842:Bone and Bones / Q000378:metabolism*; D002443:Ceftriaxone / Q000097:blood / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged
D002443:Ceftriaxone
Diffusion de la ceftriaxone dans le tissu osseux humain.