Measurement of beta-2-microglobulin in human cerebrospinal fluid by ELISA technique.
This study introduces an enzyme-linked immunosorbent assay for measurement of beta-2-microglobulin in human cerebrospinal fluid. The concentration of beta-2-microglobulin in cerebrospinal fluid correlated with the age (p less than 0.001) of a control group of 40 subjects, probably reflecting age-related processes in the central nervous system. The reference interval of beta-2-microglobulin was considered to be 0.62-3.28 mg/1. Results obtained with various CNS disorders demonstrated that estimation of beta-2-microglobulin in cerebrospinal fluid add diagnostic information. The concentration of beta-2-microglobulin may increase without simultaneous aberrations in the content of protein, glucose and white blood cells.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000134:cerebrospinal fluid; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid*; D002544:Cerebral Infarction / Q000134:cerebrospinal fluid; D004660:Encephalitis / Q000134:cerebrospinal fluid; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000134:cerebrospinal fluid; D008228:Lymphoma, Non-Hodgkin / Q000134:cerebrospinal fluid; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid; D008875:Middle Aged; D013577:Syndrome; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid*
D001613:beta 2-Microglobulin