Reduction of cis-dichlorodiammineplatinum(II) caused nephrotoxicity by indazolone carboxylic acid.
To reduce the nephrotoxicity of cis-dichlorodiammineplatinum (cis-DDP) we have used tetrahydroindazolonedicarboxylic acid (HIDA) in doses of 200, 100 or 50 mg/kg 4, 2 and 1 h before or 1, 2 and 4 h after cis-DDP treatment (10 mg/kg). At any dose, given 2 or 1 h before or 1 h after cis-DDP, HIDA reduced the kidney damage as judged by the blood urea nitrogen (BUN) levels in blood. No protective effect was seen when HIDA was given 4 h before cis-DDP injection. Studies in vitro on L1210 cells have revealed that HIDA does not directly interact with cis-DDP.
D000818:Animals; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000009:adverse effects*; D007191:Indazoles / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced*; D007939:Leukemia L1210 / Q000473:pathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009336:Necrosis / Q000473:pathology; D011720:Pyrazoles / Q000494:pharmacology*
D007191:Indazoles; D011720:Pyrazoles; C051797:4,5,6,7-tetrahydro-3-oxo-2H-indazole-5,5-dicarboxylic acid; D002945:Cisplatin