title: Tropomyosin co-localizes with actin microfilaments and microtubules within supporting cells of the inner ear.
abstract: The distribution of tropomyosin, actin and tubulin in the supporting cells of the organ of Corti was studied by immunofluorescent localization of antibodies to these proteins. Tropomyosin colocalizes with actin and tubulin in the regions of the tunnel pillar and Deiters cells where actin microfilaments and microtubules had previously been observed ultrastructurally. Despite the implications of the presence of antiparallel actin filaments in the supporting cells, the presence of tropomyosin and the absence of myosin suggest that the role of tropomyosin may be to confer rigidity to the actin filaments. Thus the primary function of the cytoskeletal proteins in the supporting cells may be structural.
mesh_terms: D008841:Actin Cytoskeleton / Q000648:ultrastructure*; D000199:Actins / Q000032:analysis*; D000818:Animals; D000906:Antibodies; D002682:Chinchilla; D003599:Cytoskeleton / Q000648:ultrastructure*; D005455:Fluorescent Antibody Technique; D008870:Microtubules / Q000648:ultrastructure*; D009925:Organ of Corti / Q000033:anatomy & histology / Q000166:cytology*; D014335:Tropomyosin / Q000032:analysis*
chemical_list: D000199:Actins; D000906:Antibodies; D014335:Tropomyosin