title: Ageing changes in the bovine kidney.
abstract: A study of macroscopically normal bovine kidneys from three age groups (neonatal calves, 2.5- to 3-year-old bullocks and cull cows), with no abnormalities on urine analysis, was carried out by light microscopy, immunofluorescence and electron microscopy. There was a slight increase in the proportion of involuted nephrons with increasing age but the proportion of nephrons affected was not greater than 10 per cent in any age group. In contrast to the findings of earlier workers, no evidence of diffuse proliferative glomerulonephritis was found in the material examined. It was concluded that the above techniques should be applied to the investigation of renal disease in cattle, as has already been done in man and small domestic animals.
mesh_terms: D000375:Aging; D000818:Animals; D002417:Cattle; D005260:Female; D005455:Fluorescent Antibody Technique; D007668:Kidney / Q000166:cytology / Q000254:growth & development*; D007672:Kidney Cortex / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron