[Esophageal angina: detection by esophageal manometry with the methylergometrin maleate test].
The purpose of this study was to assess the value of methylergonovine maleate administration as challenge test for abnormal oesophageal contractions. Manometric exploration of the oesophagus was performed before and after administration of methylergonovine maleate 0.4 mg in 28 patients suffering from retrosternal pain of proven extracardiac origin. Six patients had unexplainably suffered when receiving the drug during coronary arteriography (group A), while 22 had experienced no pain (group B). A group of 7 control subjects were explored at the same time and with the same procedure (group C). Methylergonovine maleate produced painful oesophageal abnormal contractions in 5 of the 6 patients in group A. The 6th patient in this group and 2 patients in group B had abnormal contractions without pain. Another group B patient developed coronary arterial spasm reversed by sublingual nitroglycerin. In the 2 group A patients who received nitroglycerin, the drug rapidly relieved the retrosternal pain and the abnormal contractions induced by methylergonovine maleate. This study demonstrates the value of oesophageal manometry with methylergonovine maleate test in patients with anginal pain but normal coronary arteriography. It also highlights the need for continuous ECG monitoring during the test, even when the patients had responded negatively to methylergonovine maleate during coronary arteriography.
D004935:Esophageal Diseases / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008755:Methylergonovine; D008875:Middle Aged; D013035:Spasm / Q000175:diagnosis
D008755:Methylergonovine
L' "angor oesophagien": dépistage par manométrie oesophagienne avec test au maléate de méthylergométrine.