Regulation of arterial pressure: role of pressure natriuresis and diuresis.
The importance of the renal pressure natriuresis and diuresis mechanisms in long-term control of body fluid volumes and arterial pressure has been controversial and difficult to quantitate experimentally. Recent studies, however, have demonstrated that in several forms of chronic hypertension caused by aldosterone, angiotensin II (AngII), vasopressin, or norepinephrine and adrenocorticotropin, increased renal arterial pressure is essential for maintaining normal excretion of sodium and water in the face of reduced renal excretory capability. When renal arterial pressure was servo-controlled in these models of hypertension, sodium and water retention continued unabated, causing ascites, pulmonary edema, or even complete circulatory collapse within a few days. Apparently, other mechanisms for volume homeostasis, such as the various natriuretic and diuretic factors that have been postulated, are not sufficiently powerful to maintain fluid balance in the absence of increased renal arterial pressure when renal excretory function is reduced in these forms of hypertension. The intrarenal mechanisms responsible for pressure natriuresis and diuresis are not entirely clear, but they seem to involve small increases in glomerular filtration rate and filtered load as well as reductions in fractional reabsorption in proximal and distal tubules. During chronic disturbances of arterial pressure additional factors, especially changes in AngII and aldosterone formation, act to amplify the effectiveness of the basic renal pressure natriuresis and diuresis mechanisms in regulating arterial pressure and body fluid volumes.
D000450:Aldosterone / Q000502:physiology; D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001794:Blood Pressure; D004231:Diuresis; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply / Q000502:physiology; D009318:Natriuresis; D012084:Renin-Angiotensin System; D014667:Vasopressins / Q000502:physiology
D014667:Vasopressins; D000804:Angiotensin II; D000450:Aldosterone