Effect of chronic maternal hyperkalaemia on plasma, cerebrospinal fluid and brain interstitial fluid potassium in developing rats.
Plasma hyperkalaemia was induced in pregnant and lactating rats using a high potassium diet. Fetuses of high-K-diet mothers showed no increase in the potassium concentration [( K+]) of plasma, cerebrospinal fluid (CSF) and brain interstitial fluid, presumably due to placental control. Neonates from high-K-diet rats did show an increase in plasma [K+] but this increase was very small and there was no increase in CSF or interstitial fluid [K+]. Maternal milk [K+] was not affected by plasma hyperkalaemia. Weanling rats fed the high-K diet directly showed marked plasma hyperkalaemia but no increase in CSF or interstitial fluid [K+]. Thus, prior to weaning, a relatively stable plasma [K+] is maintained by maternal influence reducing the need for direct brain fluid K+ regulation.
D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D001921:Brain; D002908:Chronic Disease; D004032:Diet; D005110:Extracellular Space / Q000032:analysis; D005260:Female; D006947:Hyperkalemia / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D007774:Lactation / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D008892:Milk / Q000032:analysis; D011188:Potassium / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D051381:Rats
D011188:Potassium