title: Legionnaires' disease--report of Singapore's first local case.
abstract: A previously healthy 27 year-old male plumber presented with six days of fever, nausea, vomiting, malaise and headache. The subsequent development of cough, dyspnoea and pleuritic pain coincided with the simultaneous development of progressive bilateral cavitary pneumonia with pleural effusion. Leucocytosis, thrombocytopenia, hyponatraemia, hypoalbuminaemia, hypophosphataemia and hypoxaemia were the main laboratory abnormalities. Clinical suspicion of Legionnaires' disease was confirmed by the presence of serum antibody to Legionella pneumophila (titre 1:512) by an indirect fluorescent antibody test. Treatment with erythromycin and rifampicin resulted in clinical recovery with minimal residual bilateral pleural effusion six months after presentation. This patient is the first to acquire Legionnaires' disease in Singapore.
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000627:therapeutic use; D005455:Fluorescent Antibody Technique; D006801:Humans; D007875:Legionella / Q000302:isolation & purification; D007877:Legionnaires' Disease / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D012293:Rifampin / Q000627:therapeutic use; D012846:Singapore
chemical_list: D004917:Erythromycin; D012293:Rifampin