title: [Stabilizing action of heavy water (D20) on the cell].
abstract: Literature data and our own findings show convincingly that heavy water (D2O) stabilizing proteins against denaturants and proteinases increases cell thermostability in plants and animals and that of microorganisms. In Drosophila, along with cell and organism thermostabilities, it enhances thermophilia. Evidence is given in favour of the suggestion that the protein stabilization is responsible for the above biological effects of D2O, although heavy water may increase the melting temperature of nucleic acids and, but slightly, of lipids.
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D002477:Cells / Q000187:drug effects* / Q000378:metabolism; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D003903:Deuterium; D004355:Drug Stability; D005656:Fungal Proteins / Q000378:metabolism; D046911:Macromolecular Substances; D008563:Membrane Lipids / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism; D011487:Protein Conformation / Q000187:drug effects; D011489:Protein Denaturation / Q000187:drug effects; D011506:Proteins / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D005656:Fungal Proteins; D046911:Macromolecular Substances; D008563:Membrane Lipids; D008565:Membrane Proteins; D010940:Plant Proteins; D011506:Proteins; D004247:DNA; D003903:Deuterium
vernacular_title: O stabiliziruiushchem deĭstvii tiazheloĭ vody (D20) na kletku.