title: Abolition of the orthodromically evoked IPSP of CA1 pyramidal cells before the EPSP during washout of calcium from hippocampal slices.
abstract: The complex EPSP-IPSP response of CA1 pyramidal cells to orthodromic activation of Schaffer collaterals-commissural afferent fibres was monitored during washout of Ca from hippocampal slices. The IPSP was clearly abolished before the EPSP and this occurred when the extracellular Ca([Ca2+]o) had fallen to between 1.03 and 0.7 mM. The loss of the IPSP was usually associated with a temporary increase in size of the EPSP and sometimes a membrane depolarization and the appearance of spontaneous activity. As [Ca2+]o fell further these effects were reversed and eventually the EPSP was abolished when [Ca2+]o had reached between 0.78 and 0.26 mM.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D005071:Evoked Potentials; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D008564:Membrane Potentials; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D010477:Perfusion; D051381:Rats
chemical_list: D002118:Calcium