[Systolic and diastolic blood flow velocities in the left coronary artery before and following i.v. dipyridamole. Comparative measurements using a digital image processing in 2 unstenosed vessel branches].
The hemodynamic significance of coronary artery stenoses cannot be assessed by presently-used methods. Especially stenoses of small and moderate degree only reveal hemodynamic relevance during augmentation of coronary flow. It can be expected that the increase in flow is limited in a stenotic branch, compared with an unstenosed branch of the same vessel. The increase in coronary blood flow in two unstenosed branches of the same vessel, however, should be nearly identical. To prove this hypothesis, the relative increase in coronary flow was measured in two unstenosed branches of the left coronary artery by means of digital subtraction angiocardiography. Ten patients were examined before and after intravenous administration of 20 mg (on average 0.29 mg/kg body weight) dipyridamole. Dipyridamole resulted in an increase in the diameter of the left anterior descending branch (LAD) of 11% (p less than 0.005) and of the circumflex artery (RCx) of 13% (p less than 0.005). The increase in flow velocity during systole amounted to 49% in the LAD (p less than 0.001) and to 58% in the RCx (p less than 0.005); during diastole to 60% in the LAD (p less than 0.005) and 83% in the RCx (p less than 0.005). The increase in volume flow during systole amounted to 78% in the LAD (p less than 0.005) and to 89% in the RCx (p less than 0.005), during diastole to 84% in the LAD (p less than 0.005) and to 113% in the RCx (p less than 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)
D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects*; D002932:Cineangiography; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000175:diagnosis*; D003971:Diastole / Q000187:drug effects; D004176:Dipyridamole; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D012212:Rheology; D013382:Subtraction Technique; D013599:Systole / Q000187:drug effects
D004176:Dipyridamole
Systolische und diastolische Flussgeschwindigkeiten in der linken Koronararterie vor und nach Dipyridamol i.v. Vergleichende Messungen mittels digitaler Bildverarbeitung in zwei nichtstenosierten Gefässästen.