Treatment of nickel dermatitis with Trientine.
23 nickel-sensitive patients with hand eczema were treated with Trientine 300 mg daily and a placebo in a double-blind, crossover trial. No significant improvement occurred in the hand eczema. A surprising finding was that there was no detectable increase in urinary nickel excretion, in contrast to animal studies.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003300:Copper / Q000652:urine; D003877:Dermatitis, Contact / Q000188:drug therapy* / Q000652:urine; D004311:Double-Blind Method; D005029:Ethylenediamines / Q000627:therapeutic use*; D005260:Female; D006229:Hand Dermatoses / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects* / Q000652:urine; D014266:Trientine / Q000627:therapeutic use*
D005029:Ethylenediamines; D003300:Copper; D009532:Nickel; D014266:Trientine