uvrC gene function has no specific role in repair of N-2-aminofluorene adducts.
In Escherichia coli, plasmid DNA modified with N-2-aminofluorene adducts survived equally well in wild-type, uvrA, or uvrB strains. Increased sensitivity was found in uvrC and uvrD strains. Moreover, N-2-aminofluorene-mediated toxicity in the uvrC background was reversed when an additional uvrA mutation was introduced into the strain.
D004260:DNA Repair; D004269:DNA, Bacterial / Q000187:drug effects; D004926:Escherichia coli / Q000235:genetics; D005449:Fluorenes / Q000633:toxicity*; D009154:Mutation
D004269:DNA, Bacterial; D005449:Fluorenes; C012177:2-aminofluorene