In vitro and in vivo kinetics of regulated drug release from polymer matrices by oscillating magnetic fields.
The kinetics of drug release from polymer-drug matrices containing an embedded magnet was continuously monitored in vitro and in vivo. The application of an oscillating magnetic field increased the rate of drug release from the polymer matrices. Within the limits of detection the increase in release occurred immediately, remained stable for as long as the field was applied, and returned exactly to baseline upon withdrawal of the field. The increase in release was directly proportional to field amplitude. The same pattern of results were observed in vivo as in vitro, though higher strength fields were required in vivo to achieve the same effect observed in vitro.
D000818:Animals; D055590:Electromagnetic Phenomena; D007444:Inulin / Q000008:administration & dosage / Q000652:urine; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011108:Polymers; D051381:Rats; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000378:metabolism; D013696:Temperature
D004364:Pharmaceutical Preparations; D011108:Polymers; D012710:Serum Albumin, Bovine; D007444:Inulin