[Lethal effect of formaldehyde on Escherichia coli strains carrying or lacking the plasmid pKM101].
The presence of plasmid pKM101 in Escherichia coli cells results in a slight increase in their sensitivity of lethal effect of formaldehyde. Plasmid ability to sensitize bacterial cells to formaldehyde inactivation is controlled by some chromosomal (uvrE, uvrA, recA) and plasmid-borne (mucAB) genes and depends on SOS-DNA repair activity. Plasmid pKM101 is capable of decreasing the level of repair reliability of DNA damaged by formaldehyde thus causing increased bacterial sensitivity to this agent.
D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D005557:Formaldehyde / Q000633:toxicity*; D010957:Plasmids
D005557:Formaldehyde
Letal'noe deĭstvie formal'degida na shtammy Escherichia coli, soderzhashchie i ne soderzhashchie plazmidu pKM101.