Allogeneic bone marrow transplantation as primary therapy for chronic myelomonocytic leukemia.
This is the first report of a successful bone marrow transplantation for chronic myelomonocytic leukemia. A 41-year-old woman with chronic myelomonocytic leukemia received, as primary treatment, a novel preparatory regimen consisting of high dose fractionated total body irradiation and high dose VP-16 chemotherapy followed by allogeneic marrow transplantation from her histocompatible brother. The patient is now more than two years after marrow transplantation with normal blood counts and a normal bone marrow which is of donor type. For younger patients with this disease who have a histocompatible sibling donor, bone marrow transplantation may represent a valid therapeutic option with curative potential.
D000328:Adult; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000628:therapy*; D011034:Podophyllotoxin / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D012074:Remission Induction; D013997:Time Factors; D014184:Transplantation, Homologous
D011034:Podophyllotoxin