ADCC function in Mycobacterium leprae inoculated normal and immunosuppressed mice.
Normal and immunosuppressed mice were inoculated with Mycobacterium leprae obtained from untreated lepromatous patients. Besides monitoring the AFB counts in the footpads at 3,6 and 9 months post inoculation, antibody dependent cellular cytotoxicity (ADCC) function was studied. The ADCC function seen to be largely unaltered in the M. leprae infected animals, comparable to the observation made in human leprosy.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D006801:Humans; D007108:Immune Tolerance; D007918:Leprosy / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009166:Mycobacterium leprae / Q000276:immunology*