title: A study of the drop-outs in psychopharmacological research with bulimics.
abstract: Given the high drop-out rates frequently noted in drug trials with bulimic subjects, we have attempted to correlate drop-out status with a greater level of psychopathology as measured by a thorough standardized psychological assessment battery (NIMH-DIS, EDI, POMS and SCL-90). Despite a trend toward higher scores on the Paranoid Ideation Subscale of the SCL-90 among drop-outs compared to completers, there were no significant differences found between the two groups participating in a fifteen week double blind crossover study on the effectiveness of desipramine in bulimia.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002032:Bulimia / Q000188:drug therapy* / Q000523:psychology; D002986:Clinical Trials as Topic; D003891:Desipramine / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008875:Middle Aged; D010352:Patient Dropouts / Q000523:psychology*
chemical_list: D003891:Desipramine