title: Tandemly duplicated upstream control sequences mediate copper-induced transcription of the Saccharomyces cerevisiae copper-metallothionein gene.
abstract: Transcription of the Saccharomyces cerevisiae copper-metallothionein gene, CUP1, inducible by copper. By analyzing deletion and fusion mutants in the CUP1 5'-flanking region, we identified two closely related, tandemly arranged copper regulatory elements. A synthetic version of one of these elements conferred efficient copper induction on a heterologous promoter when present in two tandem copies.
mesh_terms: D001483:Base Sequence; D002872:Chromosome Deletion; D003300:Copper / Q000494:pharmacology*; D005796:Genes / Q000187:drug effects*; D005800:Genes, Fungal / Q000187:drug effects*; D005809:Genes, Regulator; D008668:Metallothionein / Q000235:genetics*; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects*
chemical_list: D003300:Copper; D008668:Metallothionein