title: Hypertension in the elderly.
abstract: The incidence of hypertension in the geriatric population is very high and is a significant determinant of cardiovascular risk in this group. The tendency for blood pressure to increase with age in westernized societies such as the United States may depend on environmental factors such as diet, stress, and inactivity. Our population tends to become more obese; to consume relatively greater amounts of sodium and lesser amounts of potassium, calcium, and magnesium; and to decrease exercising with increasing age. Senescent changes in the cardiovascular system leading to decreased vascular compliance and decreased baroreceptor sensitivity contribute not only to rising blood pressure but also to an impairment of postural reflexes and orthostatic hypotension. The hallmark of hypertension in the elderly is increased vascular resistance. Greater vascular reactivity in the elderly hypertensive patients may reflect decreased membrane sodium pump activity and decreased beta-adrenergic receptor activity as well as age-related structural changes. Treatment of diastolic hypertension in the elderly is associated with decreased cardiovascular morbidity and mortality. Although treatment of systolic hypertension may not decrease immediate cardiovascular mortality, it appears to decrease the incidence of stroke. The initial therapeutic approach to the elderly hypertensive patient should generally consist of a reduction in salt and caloric intake and an increase in aerobic exercise, i.e., walking. Drug therapy should be initiated with lower doses of medication with a special concern about orthostatic hypotension.
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001835:Body Weight; D002395:Catecholamines / Q000097:blood; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology* / Q000628:therapy; D008297:Male; D011311:Pressoreceptors / Q000502:physiology; D012083:Renin / Q000097:blood; D012965:Sodium Chloride / Q000378:metabolism
chemical_list: D000959:Antihypertensive Agents; D002395:Catecholamines; D012965:Sodium Chloride; D012083:Renin