title: Controversies in the treatment of cancer of the breast.
abstract: There are many important controversial areas in the management of breast cancer. This chapter focuses on adjuvant hormonal and chemotherapy for early-stage breast cancer. Standard care for node-positive premenopausal women is chemotherapy. However, there are still unanswered questions revolving around the administration of the treatment such as optimal timing, treatment duration, specific drugs, and dose intensity. Also, the questions of adjuvant chemotherapy for postmenopausal women, adjuvant endocrine therapy, and therapy for node-negative women are reviewed.
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008593:Menopause; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D010053:Ovary / Q000601:surgery; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D003520:Cyclophosphamide; D005472:Fluorouracil; D011241:Prednisone; D008727:Methotrexate