title: Systemic lupus erythematosus presenting with hyporeninemic hypoaldosteronism in a 10-year-old girl.
abstract: Hyperkalemia has been noted to occur spontaneously in patients with long-standing systemic lupus erythematosus who did not have advanced renal insufficiency. The patients previously described all had relatively normal renin-aldosterone systems, and the hyperkalemia was thus presumed to be secondary to a primary defect in renal tubular potassium secretion. We describe at 10-year-old girl with lupus nephritis, without significant renal insufficiency, who had hyperkalemia from hyporeninemic hypoaldosteronism postulated to be due to vasculitis involving the afferent/efferent arterioles and juxtaglomerular apparatus.
mesh_terms: D000450:Aldosterone / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D008181:Lupus Nephritis / Q000097:blood / Q000150:complications; D012083:Renin / Q000097:blood*; D014657:Vasculitis / Q000150:complications
chemical_list: D000450:Aldosterone; D012083:Renin