title: Urinary mutagenicity after controlled exposure to environmental tobacco smoke (ETS).
abstract: 20 non-smokers on a defined diet low in polycyclic aromatic hydrocarbons (PAH) were exposed to environmental tobacco smoke (ETS) in an unventilated room for 8 h. The urinary mutagenicity in the 24-h urine samples as tested with the Salmonella (TA98) microsome assay did not significantly increase after exposure to either 10 ppm CO or 20-25 ppm CO. We conclude that exposure of non-smokers to ETS does not lead to an increase in their urinary mutagenicity, provided the exposure conditions are within a realistic range.
mesh_terms: D000328:Adult; D002263:Carboxyhemoglobin / Q000378:metabolism; D003367:Cotinine / Q000378:metabolism; D004032:Diet; D004780:Environment, Controlled; D006801:Humans; D009152:Mutagenicity Tests; D009153:Mutagens / Q000652:urine*; D012486:Salmonella typhimurium / Q000187:drug effects; D012907:Smoking; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D009153:Mutagens; D014028:Tobacco Smoke Pollution; D002263:Carboxyhemoglobin; D003367:Cotinine