title: Enhanced prostaglandin I2-formation of human lymphatics during pulsatile perfusion.
abstract: Previous studies demonstrate that prostacyclin (prostaglandin I2, PGI2) is the main arachidonic acid product in human lymph vessels. Pulsatile perfusion increases and prolongs PGI2-formation as do leukotrienes (LT) such as LTC4. Thus, physical activity besides local mechanical and biochemical influences on lymph pressure and flow also stimulates local lymphatic PGI2 synthesis, a prime counterbalancing factor in lymphatic constriction induced by other eicosanoids.
mesh_terms: D000293:Adolescent; D000328:Adult; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008208:Lymphatic System / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011673:Pulsatile Flow; D013189:SRS-A / Q000494:pharmacology
chemical_list: D013189:SRS-A; D011464:Epoprostenol