Induction of c-fos and c-myc expression in T lymphocytes after treatment with recombinant interleukin 1-alpha.
Our data demonstrate that an early-acting differentiation/growth factor, such as IL 1, can induce the sequential expression of c-fos and c-myc in lymphocytes. Because such a wide variety of agents induces c-onc expression in lymphocytes, we conclude that the expression of these cellular proto-oncogenes represents a common pathway of response of lymphocytes to an exogenous stimulatory signal regardless of the nature of the factor and its receptor.
D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D013601:T-Lymphocytes / Q000502:physiology*
D007375:Interleukin-1; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger