Effect of GABAergic treatment on resting and stress-induced adrenocortical activities in the thalamic pigeon.
Muscimol was injected (0.5 mg kg-1) intravenously to either intact or thalamic-lesioned animals through a chronic catheter. Plasma samples were obtained at 7-min intervals and exhibited a moderate and transient increase in corticosterone levels in both groups, together with some symptoms of light discomfort (e.g., ptiloerection or panting). All these signs disappeared within 45 to 60 min. Intraventricular injection of bicuculline (3.5 micrograms) provoked a corticosterone profile quite similar to a stress-induced polyphasic pattern. Acute stress (electrical footshocks for 30 sec) was applied 2 hr after drug treatment. In controls, the stress-induced adrenocortical response appeared to be markedly modified after muscimol injection. The usual polyphasic rebounding profile was replaced by a monophasic one. This effect of muscimol did not occur when bicuculline had been injected in the 3rd ventricle. Bicuculline alone did not alter the stress-induced profile. GABAergic treatment had no effect on the monophasic response of thalamic-lesioned birds.
D000302:Adrenal Cortex / Q000503:physiopathology*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D010856:Columbidae / Q000502:physiology*; D003345:Corticosterone / Q000097:blood; D004558:Electric Stimulation; D005260:Female; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D013315:Stress, Psychological / Q000503:physiopathology*; D013788:Thalamus / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D003345:Corticosterone; D001640:Bicuculline