Participation of lymphoid cells in the withdrawal syndrome of opiate dependent rats.
Treatment of rats with 500 Rads whole-body ionizing irradiation prior to chronic administration of morphine reduced the severity of the naloxone induced withdrawal signs. In contrast, adoptive transfer of 2-6 X 10(8) lymphoid cells to irradiated rats prior to chronic morphine treatment completely restored the ability to manifest the withdrawal signs precipitated by naloxone. These observations offer the possibility that the immune system participates in opiate addiction.
D000818:Animals; D007116:Immunization, Passive; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D009021:Morphine Dependence / Q000276:immunology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D013375:Substance Withdrawal Syndrome / Q000139:chemically induced / Q000276:immunology*; D014916:Whole-Body Irradiation
D009270:Naloxone