title: [D-penicillamine and collagen].
abstract: D-penicillamin is widely used for the treatment of various diseases, such as cystinuria. Wilson's disease or rheumatoid arthritis. It is an osteolathyrogenic agent. This effect may explain some side-effects such as fetal dysplasias, wound healing defects, skin lesions, obliterative bronchiolitis, auto-immune abnormalities. Conversely the collagen effects of D-Penicillamin explain its use in various fibrosis states such as progressive systemic sclerosis, liver or lung fibrosis.
mesh_terms: D000629:Aminopropionitrile / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001323:Autoantibodies / Q000276:immunology; D001980:Bronchi / Q000473:pathology; D002921:Cicatrix / Q000188:drug therapy; D003094:Collagen / Q000378:metabolism*; D003095:Collagen Diseases / Q000188:drug therapy; D006527:Hepatolenticular Degeneration / Q000188:drug therapy; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy; D010396:Penicillamine / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D011347:Procollagen / Q000378:metabolism; D011658:Pulmonary Fibrosis / Q000188:drug therapy; D012595:Scleroderma, Systemic / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy
chemical_list: D001323:Autoantibodies; D011347:Procollagen; D000629:Aminopropionitrile; D003094:Collagen; D010396:Penicillamine
vernacular_title: D-pénicillamine et collagène.