Intracerebroventricular infusion of insulin alters the behavior of rats not related to food intake.
Intracerebroventricular (i.c.v.) administration of a low dose of insulin strongly increased hot-plate latencies in rats, while no alteration was found in the duration of hexobarbital-induced sleep of the animals. The amount of insulin applied did not significantly change blood glucose and insulin levels and did not evoke any apparent effects on body temperature of animals.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D006591:Hexobarbital / Q000494:pharmacology; D007276:Injections, Intraventricular; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects
D007328:Insulin; D006591:Hexobarbital