title: Effect on blood and plasma cyanide levels and on methaemoglobin levels of cyanide administered with and without previous protection using PAPP.
abstract: Hydrogen cyanide was administered intravenously at doses of 0.67 or 1.34 mg kg-1 to beagle bitches after protection with oral p-aminopropiophenone (0.5 mg kg-1). Hydrogen cyanide was also administered to unprotected bitches at the lower level (0.67 mg kg-1) only. PAPP protection caused sequestration of cyanide inside the red cells. In the case of the lower dose of cyanide this resulted in a lower plasma cyanide in protected than unprotected bitches. In the case of the higher dose it resulted in survival, despite 1.34 mg kg-1 being a known lethal dose. It is concluded that prior administration of PAPP ameliorated the effects of cyanide poisoning.
mesh_terms: D000818:Animals; D003486:Cyanides / Q000037:antagonists & inhibitors / Q000097:blood* / Q000494:pharmacology; D004285:Dogs; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D008706:Methemoglobin / Q000378:metabolism*; D011427:Propiophenones / Q000494:pharmacology*
chemical_list: D003486:Cyanides; D011427:Propiophenones; C029564:4-aminopropiophenone; D008706:Methemoglobin