title: Determination of 99mTc-DTPA clearance by a single plasma sample method.
abstract: To derive a formula for determination of 99mTc-DTPA clearance (Cl) from the radioactivity in a single plasma sample, the relation Cl = ECV/t was used, where ECV is the extracellular volume and t is the mean transit time of the tracer in the organism. By studying 99mTc-DTPA time activity curves of 45 consecutive patients we found that ECV could be estimated from the body surface area, and that t could be calculated from the radioactivity in a single plasma sample. Cl calculated by the single sample method was almost identical to Cl calculated by a standard multiple sample method (r = 0.987). It is concluded that the single sample method is accurate and that it may prove useful as a routine method provided that the method is not used in patients with 99mTc-DTPA clearance less than 30 ml min-1, since this investigation includes only patients with Cl greater than 30 ml min-1; the method is not used for children, since the test material did not contain any children; the method is only used for plasma samples drawn at 180 less than or equal to t less than or equal to 300 min.
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D008433:Mathematics; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D008954:Models, Biological; D004369:Pentetic Acid / Q000097:blood*; D013667:Technetium / Q000097:blood*; D016284:Technetium Tc 99m Pentetate; D013997:Time Factors
chemical_list: D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate