Hormonal effects on gluconeogenesis from (U-14C)glutamate in rainbow trout (Salmo gairdneri).
Blood glucose was significantly decreased by insulin (4 I.U./kg). Glucagon (1 mg/kg) and Cortisol (5 mg/kg) administration produced a significant hyperglycaemia. Insulin administration did not modify liver glycogen levels. Glucagon showed a marked liver glycogen mobilization. Cortisol stimulated liver glycogen deposition. Insulin and Glucagon showed a significant inverse effect on gluconeogenesis from (U-14C)glutamate, decreasing and increasing 14C-glucose formation respectively. Hormonal treatments did not influence the very low levels of incorporation of (U-14C)glutamate into liver and muscle glycogen.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002250:Carbon Radioisotopes; D004032:Diet; D005934:Glucagon / Q000494:pharmacology*; D005943:Gluconeogenesis / Q000187:drug effects*; D005971:Glutamates / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D012487:Salmonidae / Q000378:metabolism*; D014337:Trout / Q000378:metabolism*
D001786:Blood Glucose; D002250:Carbon Radioisotopes; D005971:Glutamates; D007328:Insulin; D005934:Glucagon; D006854:Hydrocortisone