Activation of c-ras oncogenes by mutations and amplification.
About 15% of all human tumours, including carcinomas, sarcomas, melanomas and leukaemias, contain c-ras oncogenes, which can be detected by a variety of methods. The activating lesion in the c-ras oncogenes is most often a point mutation affecting certain critical amino acid residues of its protein product. The clinical significance of c-ras oncogenes is not yet clear.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D005784:Gene Amplification; D005786:Gene Expression Regulation; D006801:Humans; D009154:Mutation; D009857:Oncogenes; D011519:Proto-Oncogenes