Normalizing effect of immunoglobulins in the treatment of endogenous infection and intestinal dysbacteriosis in irradiated mice.
It has been demonstrated in experiments on 2160 CBA mice and mice of mixed breed, irradiated by LD90/30, that therapeutical administration (subcutaneous or intraperitoneal) of immunoglobulins - homologous (polyglobulin, IgG, IgM) or heterologous - polyglobulin, IgG (from human, equine, canine blood) repeated three times, i.e., 2, 24 and 48 hours after irradiation, not only induces longer survival, but also shows a normalizing effect on the commonly developing dysbacteriosis and increased amount of intestinal microflora and, in addition, leads to suppression of postirradiation endogenous infection. Enterobacteria, enterococci, staphylococci, yeasts, disappear from the small intestine or their quantity decreases substantially in treated irradiated mice in contrast to untreated irradiated mice. In the large intestine, the amount of these organisms decreases considerably while the content of lactobacteria increases; no microbes can be found in the internal organs and in blood (or their content is small). Other conditions being equal, homologous immunoglobulins are more efficient in comparison with heterologous, this applying also to preparations containing normal antibodies to tissues.
D000818:Animals; D001419:Bacteria / Q000254:growth & development; D001424:Bacterial Infections / Q000209:etiology / Q000628:therapy*; D005260:Female; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000627:therapeutic use; D007075:Immunoglobulin M / Q000627:therapeutic use; D007420:Intestine, Large / Q000382:microbiology; D007421:Intestine, Small / Q000382:microbiology; D007422:Intestines / Q000382:microbiology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000150:complications*; D014916:Whole-Body Irradiation
D007074:Immunoglobulin G; D007075:Immunoglobulin M