Withdrawal syndrome with gradual tapering of alprazolam.
The clinical and biological correlates of gradual alprazolam withdrawal were investigated in 10 patients in a double-blind, placebo-controlled trial. During gradual alprazolam withdrawal, anxiety and plasma cortisol levels were higher than during a postwithdrawal medication-free period.
D000328:Adult; D000525:Alprazolam / Q000009:adverse effects*; D001008:Anxiety Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D001714:Bipolar Disorder / Q000188:drug therapy / Q000523:psychology; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010200:Panic; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis* / Q000209:etiology
D006854:Hydrocortisone; D000525:Alprazolam