title: Wagner resurfacing arthroplasty of the canine hip.
abstract: Twelve surface replacement arthroplasties were performed on the hips of ten mongrel dogs using scaled-down replicas of the Wagner prosthesis. The contralateral hips and two further animals served as nonoperated controls. Animals were killed 5 months postoperatively. Clinical, radiological, histological and fluorochrome-labelling studies were employed to assess the bony and soft tissue reaction to resurfacing arthroplasty. There was no clinical or radiographic evidence of prosthetic loosening. Histological examination disclosed a thick foreign body and chronic inflammatory membrane containing acrylic cement and polyethylene wear particles at the bone-cement interface of both components. Generally, the bone marrow and trabecula were viable. There was evidence of increased bony remodelling and new bone formation in the subchondral area. The similarity between the above findings and those of aseptic component loosening in man suggests a mechanism whereby wear debris initiate a biological foreign body reaction culminating in component loosening.
mesh_terms: D000077:Acetabulum / Q000473:pathology; D000818:Animals; D001843:Bone Cements / Q000633:toxicity; D004285:Dogs; D005270:Femur Head / Q000473:pathology; D005549:Foreign-Body Reaction / Q000473:pathology*; D006621:Hip Joint / Q000000981:diagnostic imaging; D006622:Hip Prosthesis; D011095:Polyethylenes / Q000633:toxicity; D011474:Prosthesis Design; D011475:Prosthesis Failure; D011859:Radiography
chemical_list: D001843:Bone Cements; D011095:Polyethylenes