IgA nephropathy and membranous nephropathy associated with hepatitis B surface antigenemia.
This is the first report of glomerular disease in a 13-year-old boy who was a carrier of hepatitis B virus both mesangial IgA and subepithelial IgG deposits in the glomeruli at the same time. The clinical findings resembled those of IgA nephropathy. On electron microscopy, electron-dense deposits were identified not only in the mesangium but also on the epithelial side of the glomerular basement membrane. Immunofluorescence and immunoperoxidase staining demonstrated hepatitis B surface antigen and hepatitis B core antigen in the glomeruli but hepatitis B e antigen was not detected. Our findings suggest hepatitis B virus antigens have a pathogenetic role in the simultaneous development of these two glomerulopathies.
D000293:Adolescent; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006509:Hepatitis B / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology; D008297:Male
D006514:Hepatitis B Surface Antigens