title: [Efficacy of the simultaneous aerosol administration of fenoterol and 2(alpha-thenoylthio)propionylglycine].
abstract: The aim of the present study was to investigate the effect of a new mucolytic drug 2-alpha-tenoiltium-propionylglycine (2-alpha-TPG) administered in spray form together with a selective beta 2 stimulant, fenoterol. A double blind test was conducted on 26 patients to whom 2-alpha-TPG-fenoterol and placebo-fenoterol were given in spray form in two daily doses for 15 days at 10 day intervals. The data suggest the existence of an additive effect between the mucolytic drug (2-alpha-TPG) and the beta 2 stimulant (fenoterol) that would justify the use of the combination in the treatment of such patients.
mesh_terms: D000336:Aerosols; D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005100:Expectorants / Q000008:administration & dosage*; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage*; D005541:Forced Expiratory Volume; D005998:Glycine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013183:Sputum / Q000187:drug effects; D013440:Sulfides; D013876:Thiophenes; D013997:Time Factors; D014783:Viscosity
chemical_list: D000336:Aerosols; D005100:Expectorants; D013440:Sulfides; D013876:Thiophenes; C035227:stepronin; D005280:Fenoterol; D005998:Glycine
vernacular_title: Efficacia della somministrazione aerosolica contemporanea del fenoterolo e della 2(alfa-tenoiltio)propionilglicina.