The significance of calcium antagonists in rat experimental tympanosclerosis.
The effect of calcium antagonists in experimental tympanosclerosis following infection with Streptococcus pyogenes and vitamin D3 intoxication has been analyzed in a rat animal model. Compared with untreated animals, calcium antagonists exert a positive effect on the degenerative process and on secondary calcification in the subepithelial layer. This effect could be substantiated planimetrically.
D000818:Animals; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004110:Diltiazem / Q000627:therapeutic use; D004432:Ear, Middle / Q000473:pathology*; D008854:Microscopy, Electron; D010033:Otitis Media / Q000188:drug therapy* / Q000209:etiology; D051381:Rats; D012598:Sclerosis; D013290:Streptococcal Infections / Q000188:drug therapy*; D013297:Streptococcus pyogenes
D002121:Calcium Channel Blockers; D004110:Diltiazem