title: Higher eukaryotic aminoacyl-tRNA synthetases in physiologic and pathologic states.
abstract: The aminoacyl-tRNA synthetases play a dual role in cell metabolism by synthesizing aminoacyl-tRNAs and an odd dinucleotide diadenosine-5', 5''-P1, P4-tetraphosphate which appears to be involved in DNA replication and the control of cell proliferation. This review is a synthesis of recent results on the structure, genetics, cell biology, physiology, role in neoplasia, and role in autoimmune myositis of the higher eukaryotic aminoacyl-tRNA synthetases.
mesh_terms: D000375:Aging / Q000502:physiology; D000596:Amino Acids / Q000378:metabolism; D000604:Amino Acyl-tRNA Synthetases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001692:Biological Transport; D002455:Cell Division; D002477:Cells / Q000201:enzymology*; D005057:Eukaryotic Cells / Q000201:enzymology* / Q000648:ultrastructure; D006728:Hormones / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000473:pathology; D013217:Starvation / Q000201:enzymology; D013347:Subcellular Fractions / Q000201:enzymology
chemical_list: D000596:Amino Acids; D001323:Autoantibodies; D006728:Hormones; D000604:Amino Acyl-tRNA Synthetases