Effect of a stable prostacyclin analogue on canine renal allograft rejection.
The effect of OP-41483 (Ono Pharmaceutical Co., Osaka, Japan), a stable prostacyclin analogue, on canine renal allograft rejection was investigated. Administration for 4 days after transplantation significantly increased renal cortical blood flow and urine output when compared with untreated dogs with renal allografts. Serum creatinine levels remained relatively low during postoperative days 1-4. Mean animal survival time was prolonged. Vascular lesions and mononuclear cell infiltration were greatly diminished in biopsy specimens removed on day 4. This stable prostacyclin analogue provided a degree of protection against canine renal allograft rejection.
D000818:Animals; D004285:Dogs; D011464:Epoprostenol / Q000627:therapeutic use* / Q000031:analogs & derivatives; D005260:Female; D006084:Graft Rejection / Q000187:drug effects*; D016030:Kidney Transplantation; D008297:Male; D011182:Postoperative Care; D011465:Prostaglandins, Synthetic / Q000627:therapeutic use*; D012079:Renal Circulation / Q000187:drug effects; D013997:Time Factors; D014556:Urine
D011465:Prostaglandins, Synthetic; D011464:Epoprostenol; C035847:ataprost