Efficacy of medical treatment as an adjunct to surgery in the treatment of secretory otitis media.
In a pilot controlled randomised trial of 38 children who had bilateral secretory otitis media, with effusion demonstrated at operation, we compared the efficacy of a six-week course of an oral decongestant--antihistamine combination and a mucolytic preparation with a control group in preventing the presence of middle-ear effusion six weeks after myringotomy and adenoidectomy. The mucolytic preparation decreased the presence of middle-ear effusion when compared to the decongestant-antihistamine combination and the control group (p = 0.06).
D000233:Adenoidectomy; D002233:Carbocysteine / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002744:Chlorpheniramine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003545:Cysteine / Q000031:analogs & derivatives*; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D057985:Multi-Ingredient Cold, Flu, and Allergy Medications; D010034:Otitis Media with Effusion / Q000188:drug therapy* / Q000601:surgery; D010656:Phenylephrine / Q000627:therapeutic use*; D010665:Phenylpropanolamine / Q000627:therapeutic use*; D011184:Postoperative Period; D011897:Random Allocation; D014432:Tympanic Membrane / Q000601:surgery
D004338:Drug Combinations; D057985:Multi-Ingredient Cold, Flu, and Allergy Medications; C037668:chlorpheniramine, phenylephrine, phenylpropanolamine drug combination; D010656:Phenylephrine; D010665:Phenylpropanolamine; D002744:Chlorpheniramine; D002233:Carbocysteine; D003545:Cysteine