Mutagenicity of the Alternaria metabolites altertoxins I, II, and III.
The Ames Salmonella typhimurium assay was used to demonstrate that an extract of the mold Alternaria alternata was mutagenic. The mutagenic extract was fractionated, and the Ames test was used to determine which fractions were mutagenic. Subsequently, altertoxins I and II and a new compound referred to as altertoxin III were isolated by liquid chromatography and shown to be hydroxyperylenequinone compounds by mass spectrometry and infrared, ultraviolet, and proton magnetic resonance spectroscopy. Altertoxins I, II, and III were mutagenic to S. typhimurium TA98, TA100, and TA1537 with and without metabolic activation.
D000528:Alternaria / Q000378:metabolism*; D001551:Benz(a)Anthracenes / Q000032:analysis / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003904:Mitosporic Fungi / Q000378:metabolism*; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D009183:Mycotoxins / Q000032:analysis / Q000494:pharmacology*; D010569:Perylene / Q000031:analogs & derivatives; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D001551:Benz(a)Anthracenes; D009183:Mycotoxins; C050235:altertoxin III; C050234:altertoxin II; C050233:altertoxin I; D010569:Perylene