The effect of rapid resuscitation upon cardiac index following thermal trauma in a porcine model.
Minipigs were divided into four experimental groups: nonburned control (C); burn, minimal resuscitation (MR); burn, standard resuscitation (SR); and burn, rapid resuscitation (RR). Resuscitation was begun 30 minutes postburn and hemodynamics were measured through 24 hours postburn. At 30 minutes postburn, the three burn groups demonstrated a significant decrease in cardiac index % (CI%). At 1 1/2 hours postburn, the RR group CI% was significantly greater than for the SR group and not significantly different from that of controls. At 2 hours postburn, fluid was abruptly decreased in the RR group and the salutary effect on CI promptly dissipated. In this model, the early decrement in CI following thermal injury is responsive to rapid resuscitation, concluding that the etiology of decreased CI following thermal trauma is at least partially due to inadequate volumes of fluid administration in the early postburn period.
D000818:Animals; D002056:Burns / Q000503:physiopathology* / Q000628:therapy; D002118:Calcium / Q000097:blood; D002302:Cardiac Output; D004195:Disease Models, Animal; D005440:Fluid Therapy / Q000379:methods*; D006439:Hemodynamics; D006947:Hyperkalemia / Q000378:metabolism; D012964:Sodium / Q000097:blood; D013156:Splenectomy; D013552:Swine; D013556:Swine, Miniature
D012964:Sodium; D002118:Calcium