title: Midtrimester sonographic diagnosis of mandibulofacial dysostosis.
abstract: Two fetuses at risk for mandibulofacial dysostosis (MFD) were monitored sonographically during the midtrimester of pregnancy. Normal facial and auricular structure were identified in one fetus, and a healthy infant was subsequently delivered. Severe microtia and micrognathia were apparent in the second fetus and a diagnosis of MFD was made and confirmed at delivery. These observations indicate that midtrimester sonographic diagnosis of severe MFD is possible.
mesh_terms: D000328:Adult; D003394:Craniofacial Dysostosis / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008334:Mandible / Q000002:abnormalities*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014463:Ultrasonography