Importance of the dermal-epidermal junction and recent advances.
The zone of human skin between the epidermis and dermis is called the dermal-epidermal junction (DEJ). The importance of the DEJ is outlined and three new areas of research involving the DEJ are reviewed: the intracellular pool of bullous pemphigoid antigen, the interactions between fibronectin and keratinocytes and the epidermolysis bullosa acquisita antigen.
D001324:Autoantigens / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology / Q000502:physiology; D002352:Carrier Proteins; D002463:Cell Membrane Permeability; D003094:Collagen; D003238:Connective Tissue / Q000502:physiology; D003598:Cytoskeletal Proteins; D000071821:Dystonin; D000078404:Epidermal Cells; D004817:Epidermis / Q000276:immunology / Q000502:physiology*; D004820:Epidermolysis Bullosa / Q000276:immunology; D005109:Extracellular Matrix / Q000502:physiology; D005353:Fibronectins / Q000502:physiology; D006801:Humans; D007797:Laminin / Q000502:physiology; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D012867:Skin / Q000166:cytology / Q000276:immunology; D012879:Skin Physiological Phenomena; D000097805:Collagen Type XVII
D001324:Autoantigens; D002352:Carrier Proteins; D003094:Collagen; D003598:Cytoskeletal Proteins; D000071821:Dystonin; D005353:Fibronectins; D007797:Laminin; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII; C486268:DST protein, human; C044589:epidermolysis bullosa acquisita antigen