Mechanism of hypotensive action of ketanserin in men.
The mechanism of the hypotensive action produced by ketanserin during chronic treatment in humans remains unknown. In contrast to previous reports, recent data show that ex vivo inhibition of the serotonin-induced platelet aggregation can be demonstrated in men during chronic ketanserin administration, provided that the pH is controlled in the in vitro assay. This test could be used as a tool to measure the degree of serotonin inhibition, at least at the platelet level.
D000959:Antihypertensive Agents / Q000494:pharmacology*; D006801:Humans; D007650:Ketanserin / Q000494:pharmacology*
D000959:Antihypertensive Agents; D007650:Ketanserin