Platinum(IV) chloride complexes with heterocyclic ligands.
Platinum(IV) chloride complexes with heterocyclic ligands have been prepared and characterized by infrared and electronic spectra. The compounds are of general formula Pt(L)nCl4, where L = N-ethylimidazole, N-propylimidazole, isoxazole, 3,5-dimethylisoxazole, benzoxazole, 2-methylbenzoxazole, 2,5-dimethylbenzoxazole, ethylenediamine, n = 2, 4, and also Pt(enEt2)3Cl4 X 2H2O, where enEt2 = N,N-diethylethylenediamine. These complexes are hexacoordinate with cis or trans configuration. The antitumoral activity of some complexes in mice inoculated with leukemia L1210 is reported.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D005029:Ethylenediamines / Q000138:chemical synthesis* / Q000627:therapeutic use; D007093:Imidazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D007202:Indicators and Reagents; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D007939:Leukemia L1210 / Q000188:drug therapy; D008297:Male; D051379:Mice; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use; D010080:Oxazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D013053:Spectrophotometry; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D005029:Ethylenediamines; D007093:Imidazoles; D007202:Indicators and Reagents; D007555:Isoxazoles; D009944:Organoplatinum Compounds; D010080:Oxazoles