title: Insulin-like effect of dichloroacetic acid on hexose transport in Swiss 3T3 cells.
abstract: Hexose transport in Swiss 3T3 cells was increased by treatment with dichloroacetic acid as well as by treatment with insulin. Neither extra- nor intracellular Ca2+ was found to be involved in their stimulatory action. On the other hand, the removal of intracellular Mg2+ resulted in a loss of the stimulation. These results suggest that dichloroacetic acid stimulates the hexose transport in Mg2+-dependent manner, similar to that of insulin.
mesh_terms: D019325:3-O-Methylglucose; D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology; D002460:Cell Line; D003999:Dichloroacetic Acid / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D006601:Hexoses / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology; D008757:Methylglucosides / Q000378:metabolism; D051379:Mice
chemical_list: D000085:Acetates; D006601:Hexoses; D007328:Insulin; D008757:Methylglucosides; D019325:3-O-Methylglucose; D003999:Dichloroacetic Acid; D008274:Magnesium; D005947:Glucose; D002118:Calcium