Perfluorocarbon blood substitutes.
The salient physicochemical properties of the fluorocarbons are briefly reviewed, including their solubility for the physiologically important gases and their properties relevant to formulation (nonmiscibility with water). The preparations used to date are described, including their properties and compositions, with some comment about the available knowledge of the properties of the constituents. A critical review of the biological aspects and the possible uses of fluorocarbon emulsions constitutes the main body of the manuscript. Gas-transporting capabilities are considered quantitatively. The biological effects of these preparations are reviewed in in vivo, whole body systems, with some in vitro evidence where appropriate. The usefulness of these preparations investigated to date are reviewed under the broad headings of cardiovascular system, radiology, intoxications, and organ preservation. Finally, the shortcomings and potential usefulness are discussed, with recommendations for potential modifications.
D001692:Biological Transport; D001802:Blood Substitutes / Q000138:chemical synthesis / Q000276:immunology / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D004334:Drug Administration Schedule; D005466:Fluorocarbons / Q000008:administration & dosage; D005740:Gases / Q000378:metabolism; D006470:Hemorrhage / Q000188:drug therapy; D006801:Humans; D008658:Inactivation, Metabolic; D007263:Infusions, Parenteral; D007511:Ischemia / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy
D001802:Blood Substitutes; D005466:Fluorocarbons; D005740:Gases; C050455:fluosol