Cerebral arteriovenous malformations, steal, and the hypertensive breakthrough threshold. An experimental study in rats.
An experiment was designed to investigate the effects of arteriovenous (AV) fistula occlusion on cerebral autoregulation. A right carotid-jugular fistula was created in 63 rats in such a way as to produce an intracranial AV fistula with a loop extension into the neck. The fistula was occluded after an 8-week interval with the rats under both normotension and metaraminol-induced hypertension, and evidence of blood-brain barrier disruption was investigated with an Evans blue dye technique. The results indicate that an intracranial AV fistula may cause cerebral steal which is responsible for a reduction in the threshold for hypertensive breakthrough following fistula occlusion.
D000818:Animals; D001794:Blood Pressure; D001812:Blood-Brain Barrier; D001929:Brain Edema / Q000209:etiology; D002545:Brain Ischemia / Q000209:etiology; D002560:Cerebrovascular Circulation; D006706:Homeostasis; D002538:Intracranial Arteriovenous Malformations / Q000503:physiopathology*; D051381:Rats