title: Randomized comparison of different prostaglandin analogues and laminaria tent for preoperative cervical dilatation. World Health Organization Special Programme of Research, Development and Research Training in Human Reproduction: Task Force on Prostaglandins for Fertility Regulation.
abstract: In an eleven-centre study, 627 nulliparous subjects in the 8th to 12th week of gestation admitted for termination of pregnancy were allocated to one of five treatments to induce pre-operative cervical dilatation. The treatments were: 0.5 mg PGE2 methyl sulphonylamide; 1.0 mg PGE1 methyl ester; 30 mg 9-methylene PGE2 free acid, 0.5 mg 15-methyl PGF2 alpha; a single medium-sized laminaria tent. The results indicate that the three PGE analogues are at least equally effective as one medium sized laminaria tent and more effective than 0.5 mg 15-methyl PGF2 alpha in producing adequate pre-operative cervical dilatation prior to vacuum aspiration. It is concluded that both pre-treatment with prostaglandin analogues and laminaria tent are effective methods for preoperative cervical dilatation and both types of treatment are associated with a low incidence of side effects. Prostaglandin analogue treatment can be administered by paramedical personnel but laminaria tent insertion has to be performed by medical staff.
mesh_terms: D015064:16,16-Dimethylprostaglandin E2 / Q000009:adverse effects / Q000031:analogs & derivatives; D000019:Abortifacient Agents; D000293:Adolescent; D000328:Adult; D000527:Alprostadil / Q000009:adverse effects / Q000031:analogs & derivatives; D002260:Carboprost / Q000009:adverse effects; D002986:Clinical Trials as Topic; D004107:Dilatation and Curettage; D015232:Dinoprostone / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007795:Laminaria; D011453:Prostaglandins / Q000008:administration & dosage / Q000009:adverse effects; D011459:Prostaglandins E, Synthetic / Q000009:adverse effects; D011897:Random Allocation; D012624:Seaweed; D014619:Vacuum Curettage
chemical_list: D000019:Abortifacient Agents; D011453:Prostaglandins; D011459:Prostaglandins E, Synthetic; C025505:meteneprost; C021182:gemeprost; C016767:sulprostone; D002260:Carboprost; D000527:Alprostadil; D015232:Dinoprostone; D015064:16,16-Dimethylprostaglandin E2