Topical steroid, cyclosporin A, and the outcome of rat corneal allografts.
The effects of a combination of topical corticosteroid and cyclosporin A on corneal graft survival were tested in a model of penetrating keratoplasty in the inbred rat. Topical medications were applied four times daily to the graft for 28 days postgraft. Neither topical steroid (1% prednisolone acetate) nor topical cyclosporin (1% in chremophor EL/ethanol) was able to modify the overall incidence of rejection, though all steroid-containing medications delayed the onset of rejection significantly. The combined formulation of steroid plus cyclosporin A caused a reduction in the incidence of rejection which did not reach statistical significance and which did not eliminate the response in all animals. The chremophor/ethanol vehicle was reasonably well tolerated but did cause some periocular dermatitis.
D000287:Administration, Topical; D000818:Animals; D016039:Corneal Transplantation; D003524:Cyclosporins / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006084:Graft Rejection / Q000187:drug effects*; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains
D003524:Cyclosporins; C009935:prednisolone acetate; D011239:Prednisolone