Pancreatic beta-cell secretion after oral glucose and intravenous glucagon: different responses to dietary control of plasma glucose in newly diagnosed patients with NIDDM.
Pancreatic beta-cell secretion after oral glucose or intravenous glucagon stimulation was studied in newly diagnosed patients with non-insulin-dependent diabetes mellitus (NIDDM) before and after glycemic control by diet treatment alone. Insulin secretion to oral glucose showed significant improvement, while C-peptide release by glucagon showed no significant difference before and after diet treatment. The finding suggests that pancreatic beta-cell response to oral glucose varies with different metabolic states, but this is not so after glucagon stimulation in NIDDM patients.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002096:C-Peptide / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000178:diet therapy*; D004032:Diet; D005260:Female; D005934:Glucagon; D005947:Glucose; D006801:Humans; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D005934:Glucagon; D005947:Glucose