Pharmacokinetics and bioavailability of a controlled release amoxicillin formulation.
The pharmacokinetics and bioavailability of an in vitro controlled release amoxicillin formulation were studied in nine healthy volunteers, in comparison with an intravenous injection and a conventional tablet. The experiment was designed in a crossover fashion. The volunteers received the three formulations on separate occasions. The antibiotic was measured in plasma using a microbiological method. The absolute bioavailability of the two solid dosage forms was estimated comparing non-compartmental parameters. The results indicated that there was no correlation between the in vitro dissolution rate and the pharmacokinetic behavior in the body.
D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000378:metabolism*; D001682:Biological Availability; D003692:Delayed-Action Preparations; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D012995:Solubility; D013607:Tablets
D003692:Delayed-Action Preparations; D013607:Tablets; D000658:Amoxicillin