Avoidance facilitation in adult mice by prenatal administration of the nootropic drug oxiracetam.
CD-1 mice prenatally exposed to saline solution or to the nootropic drug oxiracetam (50 mg/kg during the whole pregnancy) were tested, when adults, for locomotor activity and for shuttle-box avoidance acquisition. Prenatal drug exposure produced long-lasting effects, evident in mature offspring. At the age of two months, mice prenatally exposed to oxiracetam showed a slight but significant reduction in locomotor activity. At the age of three months, these animals exhibited higher performances than control mice in avoidance acquisition.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D005260:Female; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011247:Pregnancy; D011759:Pyrrolidines / Q000494:pharmacology*
D011759:Pyrrolidines; C040619:oxiracetam