Effects of plant-derived flavonoids and polyphenolic acids on the activity of mutagens from cooked food.
The ability of 3 plant flavonoids (morin, myricetin and quercetin) and 4 polyphenolic acids (caffeic acid, chlorogenic acid, ellagic acid and ferulic acid) to inhibit the genotoxic effects of a number of cooked-food mutagens (IQ, MeIQ, MeIQx, Trp-P-1 and Trp-P-2), was investigated in a bacterial mutation assay using Salmonella typhimurium TA98 as indicator and hepatic S9 mixes from either SWR mice or Syrian hamsters as metabolic activating systems. Although the polyphenolic acids failed to have an effect, the flavonoids generally inhibited IQ, MeIQ, MeIQx and Trp-P-1 induced mutagenesis in a dose-dependent manner, irrespective of the source of S9. This was not the case with Trp-P-2 where the flavonoids were only observed to inhibit when SWR mouse S9 but not Syrian hamster S9 was used. Of the 3 compounds, myricetin and quercetin were superior to morin in their inhibitory capacity.
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D001711:Biotransformation; D002109:Caffeic Acids / Q000494:pharmacology*; D002726:Chlorogenic Acid / Q000494:pharmacology*; D002934:Cinnamates / Q000494:pharmacology*; D003373:Coumaric Acids / Q000494:pharmacology*; D006224:Cricetinae; D004347:Drug Interactions; D004610:Ellagic Acid / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D005511:Food Handling; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens / Q000494:pharmacology; D009154:Mutation; D011794:Quercetin / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects*; D047309:Flavones
D001578:Benzopyrans; D002109:Caffeic Acids; D002726:Chlorogenic Acid; D002934:Cinnamates; D003373:Coumaric Acids; D004610:Ellagic Acid; D005419:Flavonoids; D009153:Mutagens; D011794:Quercetin; C040015:myricetin; C008548:morin; D047309:Flavones; C004999:ferulic acid; C040048:caffeic acid