title: DNA analysis in human disease.
abstract: The analysis of human DNA using recombinant DNA technology is fast becoming an integral part of the diagnosis, assessment, and prevention of inherited and somatic genetic disease. The rationale underlying these methods of analysis is discussed, and the nature and extent of mutational change in heritable disorders and neoplastic development is outlined.
mesh_terms: D004247:DNA / Q000032:analysis*; D004273:DNA, Neoplasm / Q000032:analysis; D004274:DNA, Recombinant; D030342:Genetic Diseases, Inborn / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*
chemical_list: D004273:DNA, Neoplasm; D004274:DNA, Recombinant; D004247:DNA