title: The neuroendocrine mechanism responsible for sexual inversion of the gonad in the protandrous hermaphroditic mollusc, Crepidula fornicata L.
abstract: An in vitro investigation has clarified the neuroendocrine mechanism responsible for the differentiation of the female gonad in the protandrous hermaphrodite Crepidula fornicata. The male gonads were used as target organs; in some experiments they were brought to a uniform resting state by prior decerebration of donor animals. When isolated in culture, most of the male gonad degenerates, leaving only the stem cells lining the wall of the acini. No ovarian autodifferentiation has been observed. A masculinizing factor, released by the nervous ganglia during the male phase, controls spermatogonial mitosis and maintenance of male differentiation. A feminizing factor, secreted by the nervous ganglia during sex inversion and the female phase and present in the hemolymph, initiates oogonial mitosis and female differentiation in the male phase gonad.
mesh_terms: D000818:Animals; D004702:Endocrine Glands / Q000502:physiology; D005724:Ganglia / Q000502:physiology; D006066:Gonads / Q000502:physiology; D057850:Hermaphroditic Organisms; D008297:Male; D008974:Mollusca / Q000502:physiology*; D009424:Nervous System Physiological Phenomena; D009865:Oocytes / Q000254:growth & development; D009867:Oogonia / Q000254:growth & development; D019849:Sex Determination Processes; D013091:Spermatogenesis