T cell subsets and Ia-positive cells in the sciatic nerve during the course of experimental allergic neuritis.
The changes of T cell subsets and Ia-positive cells in the sciatic nerve during the course of experimental allergic neuritis (EAN) in Lewis rats were studied using immunohistochemical techniques. OX-6+ Ia-positive cells and W3/13+ total T cells were found at the clinical onset of EAN. OX-6+ cells were more numerous than W3/13+ cells during all phases of the disease. In the acute phase, more W3/25+ helper T cells were found than OX-8+ suppressor/cytotoxic T cells in the sciatic nerve. In the recovery phase, W3/25+ cells were slightly fewer than OX-8+ cells. It is suggested that these changes in T cell subsets and Ia-positive cells are related to the self-limiting monophasic course of EAN.
D000818:Animals; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006651:Histocytochemistry; D007124:Immunoenzyme Techniques; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000145:classification*
D000949:Histocompatibility Antigens Class II