The extracellular matrix of stratum corneum: role of lipids in normal and pathological function.
The mammalian stratum corneum, formerly treated as a homogeneous film, is now more properly viewed as a two-compartment system. The cornified cell is protein-enriched and lipid-depleted, lying embedded in an expanded extracellular matrix of highly nonpolar lipids. Because of its strategic location between the cornified layer, this lipid matrix is responsible for many phenomena related to the permeability barrier, as well as cohesion and desquamation. Thus, manipulation of this compartment could lead to enhanced drug delivery and improved lubrication, as well.
D000473:Alkanes / Q000502:physiology; D000818:Animals; D001692:Biological Transport; D002454:Cell Differentiation; D002788:Cholesterol Esters / Q000378:metabolism; D004817:Epidermis / Q000033:anatomy & histology / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D005227:Fatty Acids / Q000502:physiology; D005614:Freeze Fracturing; D005989:Glycerides / Q000502:physiology; D006651:Histocytochemistry; D006801:Humans; D007057:Ichthyosis / Q000503:physiopathology; D008055:Lipids / Q000502:physiology*; D013107:Sphingolipids / Q000502:physiology; D013256:Steroids / Q000378:metabolism
D000473:Alkanes; D002788:Cholesterol Esters; D005227:Fatty Acids; D005989:Glycerides; D008055:Lipids; D013107:Sphingolipids; D013256:Steroids; C007045:cholesteryl sulfate