title: alpha-Methyldopa for climacteric hot flushes. A double-blind, randomized, cross-over study.
abstract: The effects of single evening doses of alpha-methyldopa and placebo have been compared in 40 women with climacteric hot flushes. The study was designed as a double-blind, randomized and cross-over investigation. Of the 24 patients who completed the study, 15 reported that they preferred the alpha-methyldopa treatment (p greater than 0.05). alpha-methyldopa seemed to affect both the severity (p less than 0.05) and the frequency of climacteric hot flushes (p greater than 0.05). It is concluded that alpha-methyldopa is efficacious against climacteric hot flushes when given as single evening doses, but further study is required to answer whether this dosage is as effective as a twice daily regimen.
mesh_terms: D002979:Climacteric / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005483:Flushing / Q000188:drug therapy*; D006801:Humans; D008750:Methyldopa / Q000008:administration & dosage*; D008875:Middle Aged; D011897:Random Allocation
chemical_list: D008750:Methyldopa