[Diagnosis of mosaic forms of karyotype anomalies in clinical cytogenetic research].
Mosaicism cases have been statistically analyzed with the aim to develop a general scheme of the cytogenetic study. Using the Bernoulli formula it is shown that when P = 0.95 and proportion of clones is 10:90% and more 29 cells should be initially analyzed. If all the cells are of the same chromosomal constitution (m = 0) the mosaicism is rejected. Mosaicism is highly probable when m = 4 and more among n = 29. When m = 1, 2 or 3 the number of cells should be increased to 44 in accordance with calculations by the formula: 1--Cnm.pm.(1--p)n-m = P.
D000568:Amenorrhea / Q000175:diagnosis / Q000235:genetics; D000782:Aneuploidy; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D005260:Female; D005821:Genetic Techniques; D006801:Humans; D007621:Karyotyping; D009030:Mosaicism
Diagnostika mozaichnykh form anomaliĭ kariotipa v kliniko-tsitogeneticheskikh issledovaniiakh.