In vivo effect of didemnin B on two tumors of the rat.
Didemnin B administered at a dose of 0.06 mg/kg, highest nontoxic dose for the rat, shows a high antitumor activity against Yoshida ascites tumor only after intraperitoneal injection of the drug; supplied by other routes both against T8 sarcoma of Guérin and Yoshida ascites tumor is ineffective.
D000818:Animals; D002460:Cell Line; D002945:Cisplatin / Q000627:therapeutic use; D047630:Depsipeptides; D005260:Female; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D009369:Neoplasms / Q000188:drug therapy*; D010456:Peptides, Cyclic / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D047630:Depsipeptides; D010456:Peptides, Cyclic; C030051:didemnins; D002945:Cisplatin