Cell-cell interaction and carcinogenesis.
Before carcinogenic stimuli are introduced, a potentially cancerous cell functions normally; growth is controlled and the cell exists in complete harmony with that of surrounding cells in a given tissue. During the process of multi-stage carcinogenesis, such harmony is destroyed and a presumptive initiated cell accomplishes a clonal expansion, neglecting the growth pattern of surrounding normal cells. Recent results from our own laboratory and others strongly suggest that blocked gap-junctional intercellular communication is an important determinant during the process of tumor promotion.
D000818:Animals; D001665:Binding Sites; D002273:Carcinogens / Q000633:toxicity; D002450:Cell Communication / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D006801:Humans; D007365:Intercellular Junctions / Q000187:drug effects / Q000502:physiology; D010703:Phorbol Esters / Q000378:metabolism / Q000633:toxicity; D011493:Protein Kinase C / Q000378:metabolism
D002273:Carcinogens; D010703:Phorbol Esters; D011493:Protein Kinase C