The synthesis of benzindene prostacyclin analogs as potential antiulcer agents.
Two new diastereomeric benzindene prostacyclin analogs (U-72,382 and U-72,383) related to the potent antiulcer agent U-68,215 have been synthesized. These cyclohexyl ring modified analogs of U-68,215 were prepared to determine how the gastrointestinal and hypotensive endpoints observed for U-68,215 would be affected.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis*; D004064:Digestive System / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D011464:Epoprostenol / Q000138:chemical synthesis* / Q000494:pharmacology / Q000031:analogs & derivatives; D007022:Hypotension / Q000139:chemically induced; D051381:Rats; D013329:Structure-Activity Relationship; D014456:Ulcer / Q000188:drug therapy
D000897:Anti-Ulcer Agents; C051823:U 72382; D011464:Epoprostenol