Effect of class I HLA matching on graft survival in sensitized patients.
First, the proportion of highly sensitized transplant candidates grows in the absence of organ sharing. The unsensitized patient is transplanted readily; the sensitized patient has restricted access because of the need for a well-matched kidney to permit a negative cross-match. Second, well-matched grafts are equally successful in sensitized and unsensitized recipients. Finally, emphasis on organ sharing would reverse the trend of accumulation of sensitized candidates without decreasing graft survival.
D005500:Follow-Up Studies; D006085:Graft Survival; D006680:HLA Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007114:Immunization; D016030:Kidney Transplantation
D006680:HLA Antigens