title: [Experimental therapy in Chinese hamsters and rats infected with larval Echinococcus multilocularis by using mebendazole, albendazole and ivermectin with brief review of chemotherapy of human multilocular echinococcosis].
abstract: The effects of the mebendazole, albendazole and ivermectin on secondary multilocular echinococcosis in Chinese hamsters infected with intraperitoneal inoculation of protoscolices and in rats infected with transportal inoculation of protoscolices were investigated. A reduction in weight of the hydatids greater than 95% was recorded in Chinese hamsters intraperitoneally injected with mebendazole suspension. Oral administration of mebendazole moderately inhibited the development of the hydatids. Albendazole was less effective than mebendazole. Ivermectin was ineffective. The treatment with mebendazole of larval E. multilocularis inhibited the growth of the hydatids but it could not completely kill the parasite tissues. The present status of chemotherapy of the human multilocular echinococcosis was briefly discussed.
mesh_terms: D015766:Albendazole; D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D006224:Cricetinae; D003412:Cricetulus; D004443:Echinococcosis / Q000188:drug therapy*; D006801:Humans; D007559:Ivermectin / Q000627:therapeutic use*; D007814:Larva; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use*; D051381:Rats
chemical_list: D001562:Benzimidazoles; D007559:Ivermectin; D008463:Mebendazole; D015766:Albendazole