Progressive supranuclear palsy and a multi-infarct state.
In 58 patients with progressive supranuclear palsy (PSP), 19 (32.8%) had CT, MRI, or autopsy evidence of a multi-infarct (MI) state. The clinical findings in the infarct syndrome were similar to idiopathic PSP. Five MI-PSP patients had had a stroke, four had focal dystonia, two had hemiparesis, and one had an intention tremor of recent onset. In contrast, only 5.9% (12.9% of those with CT or MRI) of 426 Parkinson's disease patients had evidence of strokes. One case of PSP studied pathologically was attributed to cerebral amyloid angiopathy.
D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000150:complications*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications; D013494:Supranuclear Palsy, Progressive / Q000209:etiology* / Q000473:pathology; D014057:Tomography, X-Ray Computed