title: Anti-inflammatory property of ranitidine, a specific H2-receptor antagonist.
abstract: The effects of ranitidine (2 mg/kg, po) and phenylbutazone (100 mg/kg po) have been studied in different models of acute and chronic inflammation in rats. Ranitidine showed significant anti-inflammatory activity in the four models used. This observation supports the concept that histamine has a pro-inflammatory role that is mediated via stimulation of H2-receptors.
mesh_terms: D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D002351:Carrageenan; D002908:Chronic Disease; D005260:Female; D006099:Granuloma / Q000188:drug therapy; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D010538:Peritonitis / Q000188:drug therapy; D011899:Ranitidine / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D014425:Turpentine
chemical_list: D000893:Anti-Inflammatory Agents; D011899:Ranitidine; D002351:Carrageenan; D014425:Turpentine