Genetic toxicology evaluation of the novel semi-synthetic antibiotic piperacillin.
Piperacillin (T-1220, Pipracil) a semi-synthetic antibiotic was evaluated in a battery of genetic toxicology assays. The assays employed were: the microbial assay, the host mediated assay, the microbial assay incorporating urine samples from mice dosed with piperacillin, the in vivo cytogenetic assay, and the dominant lethal assay. In all assays, piperacillin produced consistent negative results indicating that piperacillin does not have mutagenic potential.
D000818:Animals; D002869:Chromosome Aberrations / Q000187:drug effects; D005260:Female; D005799:Genes, Dominant / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D010878:Piperacillin / Q000633:toxicity* / Q000652:urine; D011247:Pregnancy; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics
D009153:Mutagens; D010878:Piperacillin