title: [S-100 protein in non-pigmented melanocytic and neuro-ectodermal tumors of the conjunctiva].
abstract: Using an immunoperoxidase method, S-100 protein was localized in 51 nonpigmented or slightly pigmented nevi, eight malignant melanomas, three neurofibromas, and one neurilemmoma of the conjunctiva. Clinico-immunohistochemical correlations are presented. Cells of these neuroectodermal tumors contain S-100 protein. Epithelial invaginations arising from the conjunctival surface and lying between melanocytes are S-100 protein-negative. This facilitates the differential diagnosis of particularly amelanotic lesions of the conjunctiva. Immunohistochemical identification of the S-100 protein represents an improvement in current histochemical differential diagnosis of these tumors.
mesh_terms: D003228:Conjunctiva / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007124:Immunoenzyme Techniques; D008545:Melanoma / Q000473:pathology*; D009442:Neurilemmoma / Q000473:pathology*; D009455:Neurofibroma / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism*
chemical_list: D009418:S100 Proteins
vernacular_title: S-100 Protein in nicht-pigmentierten melanozytären und neuroektodermalen Tumoren der Konjunktiva.