Antibodies against the paramyxovirus SV5 in the cerebrospinal fluids of some multiple sclerosis patients.
Multiple sclerosis is a demyelinating disease of the central nervous system and although there is little doubt that an infectious agent (or agents) is involved it has not been possible to demonstrate this unequivocally by any direct relationship to a given agent. Here we show that a significant proportion of patients with multiple sclerosis have antibodies against the paramyxovirus SV5 (simian virus 5) in their cerebrospinal fluid and in some of these such antibodies form a major proportion of the total immunoglobulin content. Further, we have been able to demonstrate that the oligoclonal bands displayed on electrophoresis of the cerebrospinal fluid of these patients can be removed by prior absorption with SV5 virus antigen.
D000914:Antibodies, Viral / Q000134:cerebrospinal fluid*; D000956:Antigens, Viral; D002498:Centrifugation; D004591:Electrophoresis, Polyacrylamide Gel; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid; D007163:Immunosorbent Techniques; D008459:Measles virus / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology*; D010252:Paramyxoviridae / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007136:Immunoglobulins