title: [A formulation of iopamidol for the radiologic examination of the gastrointestinal tract. Preclinical studies].
abstract: Animal studies were carried out using an oral solution of a low osmolality non ionic contrast medium iopamidol, developed for gastrointestinal examinations. The new formulation was evaluated for image quality in studies of the upper and lower gastrointestinal tract. Margins of safety were defined by subjecting the compound to a number of toxicological and pharmacological experiments. The experiments were designed to reveal qualitative and quantitative differences between the formulation of iopamidol and Gastrografin, a conventional ionic contrast medium. The results indicate that the formulation of iopamidol is safer than a conventional hypertonic water soluble contrast medium and diagnostically superior in the gastrointestinal tract examinations.
mesh_terms: D000818:Animals; D004064:Digestive System / Q000000981:diagnostic imaging* / Q000378:metabolism; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004947:Esophagus / Q000000981:diagnostic imaging*; D007479:Iopamidol / Q000009:adverse effects / Q000378:metabolism; D007700:Kinetics; D011817:Rabbits; D011859:Radiography; D051381:Rats
chemical_list: D007479:Iopamidol
vernacular_title: Formulazione di iopamidolo per l'esame radiologico del tratto gastro-intestinale. Studi preclinici.