Treatment of imported cases of falciparum malaria in France with halofantrine.
Halofantrine is a 9-phenanthrenemethanol which is effective against multi-drug resistant strains of Plasmodium falciparum. It has been shown to be highly effective and extremely well tolerated in the treatment of imported cases of falciparum malaria in France. A total of 1,500 mg administered in three 500 mg doses at six-hour intervals results in a 100% cure rate in semi-immune subjects. This dosage should be repeated after 14 days to obtain the same cure rate in non-immune patients. Minor clinical side effects included epigastric pains, nausea and, in one case, a skin rash.
D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D005260:Female; D005602:France; D006801:Humans; D008288:Malaria / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010616:Phenanthrenes / Q000008:administration & dosage / Q000627:therapeutic use*; D010963:Plasmodium falciparum
D000962:Antimalarials; D010616:Phenanthrenes; C023768:halofantrine