title: Alpha-ecdysone, a new bracken fern factor responsible for neoplasm induction in the Egyptian toad (Bufo regularis).
abstract: Neoplastic lesions were induced in 10 out of 58 experimental toads (Bufo regularis) force-fed with alpha-ecdysone, which naturally occurs in the leaves of bracken fern (Pteris aquilina). The results of this study prove that alpha-ecdysone may be one of the factors responsible for the carcinogenicity of bracken fern plant fed to cattle and other experimental animals.
mesh_terms: D000818:Animals; D002025:Bufonidae; D004440:Ecdysone / Q000633:toxicity*; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010947:Plants, Toxic / Q000032:analysis*
chemical_list: D004440:Ecdysone