[Action of dibunol, isoptin and their combination in transitory myocardial ischemia in waking rabbits].
Effects of dibunol, isoptin and their combination were studied on 80 conscious rabbits with transient myocardial ischemia. Prophylactic (for 4 days before experiment in a dose of 20 mg/kg) and therapeutic (2 days, 40 mg/kg) intraperitoneal administration of dibunol resulted in a diminution of necrosis size and a decrease of the number of ventricular fibrillations in the period of the coronary artery occlusion. Administration of isoptin (0.4 mg/kg intravenously during transient ischemia) was followed by a restriction of necrotic focus. A combined therapeutic administration of dibunol and isoptin provided a significant diminution of myocardial necrosis size, the number of ventricular fibrillations and stabilized the level of malondialdehyde in the blood plasma. The role of peroxide destruction of membranes and calcium overload of cardiomyocytes in the pathogenesis of irreversible ischemic damage of the myocardium is discussed.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D008297:Male; D011817:Rabbits; D013997:Time Factors; D014700:Verapamil / Q000627:therapeutic use*; D014851:Wakefulness / Q000502:physiology*
D000975:Antioxidants; D002121:Calcium Channel Blockers; D002084:Butylated Hydroxytoluene; D014700:Verapamil
Issledovanie deĭstviia dibunola, izoptina i ikh kombinatsii v usloviiakh tranzitornoĭ ishemii miokarda u bodrstvuiushchikh krolikov.