Inhibition of biosynthesis of Saccharomyces cerevisiae sugar transport system by tunicamycin.
Tunicamycin apparently inhibited the biosynthesis of glucose, galactose, and maltose transport systems in Saccharomyces cerevisiae. Under the conditions used, the antibiotic also blocked the biosynthesis of invertase, a well-known yeast glycoprotein, as well as the glycosylation of a marker mannoprotein of the yeast cell wall. However, the antibiotic did not affect certain proteins which did not contain carbohydrate. It seems, therefore, that these sugar carriers are glycoproteins.
D050260:Carbohydrate Metabolism; D002352:Carrier Proteins / Q000096:biosynthesis*; D003864:Depression, Chemical; D005656:Fungal Proteins / Q000096:biosynthesis*; D006023:Glycoproteins / Q000096:biosynthesis; D006026:Glycoside Hydrolases / Q000096:biosynthesis; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism; D014415:Tunicamycin / Q000494:pharmacology*; D043324:beta-Fructofuranosidase
D002352:Carrier Proteins; D005656:Fungal Proteins; D006023:Glycoproteins; D014415:Tunicamycin; D006026:Glycoside Hydrolases; D043324:beta-Fructofuranosidase