Temperature-dependent effects of the components of kallikrein-kinin system on sperm motility in vitro.
The effect of kallikrein and bradykinin on sperm motility was studied. For investigation of whether the effect is not temperature dependent, sperm motility and velocity were measured after incubation with kallikrein or bradykinin at different temperatures. The effect of kallikrein on sperm motility and velocity was demonstrated significantly at 22 degrees C. At 37 degrees C, this effect was absent, but with captopril the effect of kallikrein on sperm velocity was observed. Bradykinin stimulated sperm motility and velocity at 22 degrees C and at 33 degrees C. However, it did not stimulate sperm motility at 37 degrees C. With 1.10 phenantroline, the effect of bradykinin on sperm motility was detected. These results indicate that kallikrein and bradykinin stimulate sperm motility and velocity and that their effects are strongly temperature dependent.
D001920:Bradykinin / Q000494:pharmacology*; D002216:Captopril / Q000494:pharmacology; D004357:Drug Synergism; D006801:Humans; D007610:Kallikreins / Q000494:pharmacology*; D008297:Male; D010618:Phenanthrolines / Q000494:pharmacology; D013081:Sperm Motility / Q000187:drug effects; D013268:Stimulation, Chemical; D013696:Temperature
D010618:Phenanthrolines; D002216:Captopril; D007610:Kallikreins; D001920:Bradykinin