[Electrophysiological study of the cardiotropic action of phenothiazine-derivative anti-arrhythmia preparations].
Cardiotropic action of antiarrhythmic agents etmozin and etacizin, phenothiazine derivatives, was studied electrophysiologically in 42 mongrel dogs (using isolated heart and intact body models). Etmozin produced no direct effect on sinus node function, whereas etacizin suppressed it in isolated hearts. Etmozin and etacizin significantly affected the atrial, atrioventricular-node and His-Purkinje conduction time, having no basic effect on the duration of respective refractory periods. Therefore, they can be referred to antiarrhythmic agents, group 1, subclass C. The magnitude and pattern of etmozin-and etacizin-induced electrophysiologic changes in the isolated heart and the integrated system are basically similar, an evidence of cardiotropic effects of these drugs. The model of an isolated dog heart perfused by a donor dog's blood can be used for the assessment of cardiotropic effects of drugs in preclinical trials of new antiarrhythmic agents.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D004285:Dogs; D004594:Electrophysiology; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006329:Heart Conduction System / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D016293:Moricizine / Q000031:analogs & derivatives; D010640:Phenothiazines / Q000494:pharmacology*; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; C027240:diethylamino-ethmozine; D016293:Moricizine
Elektrofiziologicheskoe issledovanie kardiotropnogo deĭstviia antiaritmicheskikh preparatov, proizvodnykh fenotiazina.