title: A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas.
abstract: Deposition of amyloid is the most constantly present alteration in the islets of Langerhans in type 2 diabetes mellitus and is also quite common in insulin-producing tumors of the pancreas and it is very likely that these two amyloids are identical. We have isolated amyloid fibrils from an insulin-secreting human tumour and purified the fibrillar protein. N-terminal amino acid sequence of the protein is unique and does not resemble insulin or its precursors. Instead it has about 50% homology with the neuropeptide CGRP (calcitonin gene related peptide).
mesh_terms: D000595:Amino Acid Sequence; D000682:Amyloid / Q000235:genetics / Q000302:isolation & purification*; D015740:Calcitonin Gene-Related Peptide; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000302:isolation & purification; D009479:Neuropeptides / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000032:analysis / Q000378:metabolism
chemical_list: D000682:Amyloid; D007328:Insulin; D009363:Neoplasm Proteins; D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide