[Induction of unscheduled DNA synthesis in the nuclear matrix of rat hepatocytes after whole-body gamma irradiation of the animals].
DNA synthesis in hepatocytes was studied by incorporation of [3H]thymidine administered to portal vein of gamma-irradiated (80 Gy) rats. It was shown that the rate of replicative DNA synthesis decreased in hepatocytes of the regenerating liver and unscheduled DNA synthesis was induced at the nuclear matrix of resting cells of the intact liver. In addition to repair synthesis, DNA synthesis resembling replicative one ("aberrant" DNA synthesis) accounts for a considerable fraction of gamma-radiation-induced synthesis of DNA at the nuclear matrix.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism / Q000528:radiation effects*; D002843:Chromatin / Q000378:metabolism / Q000528:radiation effects; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects*; D004249:DNA Damage; D005720:Gamma Rays; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism / Q000528:radiation effects*; D008115:Liver Regeneration / Q000528:radiation effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014916:Whole-Body Irradiation
D002843:Chromatin; D004247:DNA; D013936:Thymidine
Induktsiia vneplanovogo sinteza DNK na iadernom matrikse gepatotsitov krys posle obshchego gamma-oblucheniia zhivotnykh.