title: Hepatic effects of acetaminophen. Enhanced toxicity in alcoholics.
abstract: Alcoholic patients run an increased risk of developing hepatotoxicity from doses of acetaminophen within or only moderately above the recommended usual therapeutic doses. In this review I examine the scientific evidence and clinical observations that indicate such a heightened susceptibility of the alcoholic to acetaminophen-induced injury.
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects* / Q000378:metabolism; D000437:Alcoholism / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008107:Liver Diseases / Q000378:metabolism; D012306:Risk
chemical_list: D000082:Acetaminophen; D000431:Ethanol