The dopaminergic inhibition of the gonadotropin-releasing hormone-induced gonadotropin release: an in vitro study with fragments and cell suspensions from pituitaries of the African catfish, Clarias gariepinus (Burchell).
Pituitary fragments and pituitary cell suspensions of the African catfish in a perifusion system released gonadotropic hormone (GTH) spontaneously. After a few hours of perifusion a baseline of GTH release was established. The dopamine (DA) agonist apomorphine (APO) caused a decreased in the release from pituitary fragments but not from pituitary cell suspensions. APO abolished the luteinizing hormone-releasing hormone analog (LH-RHa)-induced GTH release from both pituitary fragments and cell suspensions. It was concluded that DA inhibits the GTH release induced by gonadotropin-releasing hormone.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002397:Catfishes / Q000378:metabolism*; D004298:Dopamine / Q000502:physiology*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D066298:In Vitro Techniques; D010902:Pituitary Gland / Q000378:metabolism*; D011863:Radioimmunoassay
D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone; C010661:surfagon; D001058:Apomorphine; D004298:Dopamine