title: Splicing of messenger RNA precursors.
abstract: A general mechanism for the splicing of nuclear messenger RNA precursors in eukaryotic cells has been widely accepted. This mechanism, which generates lariat RNAs possessing a branch site, seems related to the RNA-catalyzed reactions of self-splicing introns. The splicing of nuclear messenger RNA precursors involves the formation of a multicomponent complex, the spliceosome. This splicing body contains at least three different small nuclear ribonucleoprotein particles (snRNPs), U2, U5, and U4 + U6. A complex containing precursor RNA and the U2 snRNP particle is a likely intermediate in the formation of the spliceosome.
mesh_terms: D000818:Animals; D001483:Base Sequence; D007438:Introns; D009154:Mutation; D009694:Nucleic Acid Precursors / Q000235:genetics*; D014176:Protein Biosynthesis; D012322:RNA Precursors; D012326:RNA Splicing; D016337:RNA, Catalytic; D012333:RNA, Messenger / Q000235:genetics*; D012335:RNA, Ribosomal / Q000235:genetics; D012342:RNA, Small Nuclear / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics; D013768:Tetrahymena / Q000235:genetics
chemical_list: D009694:Nucleic Acid Precursors; D012322:RNA Precursors; D016337:RNA, Catalytic; D012333:RNA, Messenger; D012335:RNA, Ribosomal; D012342:RNA, Small Nuclear