[Effect of lipid peroxidation on the insulin receptor in rat adipocytes].
Lipid peroxidation is studied for its effect on insulin receptors in isolated rat adipocytes. The results suggest that addition of two peroxidants (3 mM cumene hydroperoxide and 0.2 mM Fe2+) leads to malondialdehyde accumulation and binding inhibition through insulin receptors quantity and affinity decrease.
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology; D001667:Binding, Competitive; D005296:Ferrous Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D011972:Receptor, Insulin / Q000378:metabolism*
D001555:Benzene Derivatives; D005296:Ferrous Compounds; D007328:Insulin; D008054:Lipid Peroxides; D008315:Malondialdehyde; D011972:Receptor, Insulin; C007164:cumene hydroperoxide
Vliianie perekisnogo okisleniia lipidov na retseptsiiu insulina adipotsitami krys.