Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.
An activated K-ras oncogene was detected by transfection in NIH 3T3 cells and by Southern blot analysis in 6 of 12 rat skin tumors induced by ionizing radiation. The DNA from 10 of the 12 tumors also showed c-myc gene amplification and restriction polymorphisms. Evidence for tissue specificity was observed in patterns of oncogene activation, with each of three clear cell carcinomas exhibiting activation of both c-myc and K-ras oncogenes.
D000818:Animals; D004273:DNA, Neoplasm / Q000235:genetics; D005784:Gene Amplification; D005786:Gene Expression Regulation / Q000528:radiation effects; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D012333:RNA, Messenger / Q000235:genetics; D011839:Radiation, Ionizing; D051381:Rats; D012878:Skin Neoplasms / Q000235:genetics*
D004273:DNA, Neoplasm; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger