Double-blind comparison of lidocaine, tubocurarine and diazepam pretreatment in modifying intraocular pressure increases.
One hundred and sixty patients, divided randomly into four groups received normal saline (5 ml), d-tubocurarine (0.05 mg X kg-1), diazepam (0.1 mg X kg-1) or lidocaine (1 mg X kg-1) as pretreatment, in a double blind manner, five minutes before anaesthetic induction with thiopentone and succinylcholine (1 mg X kg-1). Succinylcholine caused a significant increase in IOP in all groups. However, in the lidocaine group, this increase was significantly less than that observed in the control group. The post-succinylcholine increase in IOP was further aggravated by tracheal intubation in all except the lidocaine group. A further clinical trial with higher doses of lidocaine is suggested to assess its ability to obtund the succinylcholine-induced increase in IOP. Lidocaine in a dose of 1 mg X kg-1 IV prevents the rise in IOP which follows intubation.
D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007442:Intubation, Intratracheal / Q000009:adverse effects; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D013390:Succinylcholine / Q000009:adverse effects; D014403:Tubocurarine / Q000494:pharmacology*
D008012:Lidocaine; D013390:Succinylcholine; D003975:Diazepam; D014403:Tubocurarine