title: An investigation of Ki-1 positive large cell lymphoma with antibodies reactive with tissue macrophages.
abstract: The diagnosis of true histiocytic lymphoma (THL) represents one of the most difficult and controversial areas of lymph node pathology. Recently, Stein et al. (1985) have demonstrated that a series of tumours presenting with morphological and immunocytochemical features, previously considered as being indicative of THL, share antigenic markers with Reed-Sternberg and mononuclear Hodgkin's cells and, therefore, may be derived from lymphocytes, rather than histiocytes. In this study we have re-investigated some of these cases with a panel of monoclonal antibodies variously reactive with macrophages. Although all cases contain a heavy infiltrate of reactive histiocytes the tumour populations are negative for histiocyte antigens.
mesh_terms: D000906:Antibodies; D001706:Biopsy; D006644:Histiocytes / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007158:Immunologic Techniques; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000473:pathology*; D008264:Macrophages / Q000276:immunology*
chemical_list: D000906:Antibodies