Reduced apomorphine-induced sedation following chronic stress.
In agreement with previous reports, low doses of apomorphine (10-50 micrograms/kg, 5 min before test) produced a dose-dependent decrease in motor activity of control rats. This effect was markedly attenuated 24 h after a prolonged immobilization stress (2 h daily during 7 days). A single stress session had no effect on motor activity. These behavioral observations suggest a reduced sensitivity of presynaptic dopamine receptors after chronic stress.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D006993:Hypnotics and Sedatives; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000503:physiopathology*
D006993:Hypnotics and Sedatives; D001058:Apomorphine