title: Energy status in HeLa cells after treatment with an arresting anticancer drug.
abstract: The energy status of HeLa cells arrested in the G2 phase of the cell cycle by the antineoplastic agent cis-acid was compared with that of normal G2-phase-synchronized cells. The results showed that treatment with the drug has significantly decreased the adenylate pool, adenylate energy charge and phosphorylation potential.
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism; D004734:Energy Metabolism; D005260:Female; D006367:HeLa Cells / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007399:Interphase; D008130:Lomustine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010710:Phosphates / Q000378:metabolism; D010766:Phosphorylation
chemical_list: D000227:Adenine Nucleotides; D010710:Phosphates; C013792:NSC 153174; D008130:Lomustine