Hypomania related to phenelzine and isoetharine interaction in one patient.
A case is reported of a man with apparent unipolar depression that was responsive to treatment with phenelzine who became hypomanic when isoetharine was added to treat his chronic obstructive pulmonary disease. The role of beta-adrenergic receptors in affective illness is reviewed in light of this case.
D000368:Aged; D000605:Amino Alcohols / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000139:chemically induced*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D007528:Isoetharine / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D008173:Lung Diseases, Obstructive / Q000150:complications / Q000188:drug therapy; D008297:Male; D010624:Phenelzine / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use
D000605:Amino Alcohols; D010624:Phenelzine; D007528:Isoetharine