title: Influence of antisera to pancreatic acinar cells on rat pancreas in situ.
abstract: For investigations of cell injury during pathogenesis of acute pancreatitis antisera to pancreatic acinar cells were used as experimental tool. Within one hour after intraductal injection of antiserum a strong pancreatic edema was developed. Within 24 h this edema receded to a large extent but at this time there were inflammatory cells scattered in the intra- and periductal region. As a sequel of application of antiserum pancreatic enzymes were released. At 24 h after this application serum activities of alpha-amylase and lipase were significantly increased in comparison to the control and reached that level which was found in a model of acute pancreatitis provoked by pancreatic edema plus short-term ischemia.
mesh_terms: D000208:Acute Disease; D000818:Animals; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D005260:Female; D005455:Fluorescent Antibody Technique; D007106:Immune Sera / Q000276:immunology*; D010179:Pancreas / Q000276:immunology*; D010186:Pancreatic Function Tests; D010195:Pancreatitis / Q000276:immunology*; D051381:Rats
chemical_list: D007106:Immune Sera