Phenylcyclohexylamine: effect of a metabolite of phencyclidine on the efflux of dopamine in the rat.
The effect of phenylcyclohexylamine (PCA) on the efflux of dopamine (DA) in the neostriatum was examined using in vivo electrochemical techniques. Phenylcyclohexylamine produced a long-lasting dose-dependent biphasic effect on the efflux of DA in the rat. This response, to one of the major metabolites of phencyclidine, was similar in duration to but less potent than that seen with phencyclidine.
D000818:Animals; D003514:Cyclohexylamines / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D004563:Electrochemistry; D008297:Male; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D003514:Cyclohexylamines; C037320:1-phenylcyclohexylamine; D010622:Phencyclidine; D004298:Dopamine