title: 2,3-Bisphosphoglycerate protects mitochondrial and cytosolic proteins from proteolytic inactivation.
abstract: 2,3-bisphosphoglycerate at physiological concentration similar to that found in many tissues protects effectively ornithine transcarbamoylase (OTC) from proteolytic inactivation by broken lysosomes. 2,3-bisphosphoglycerate protects also many other mitochondrial and cytosolic proteins, such as glutamate dehydrogenase (GDH) an glyceraldehyde-3-phosphate dehydrogenase (GAPDH), from proteolysis by broken lysosomes and other proteases. It is, thus, suggested that 2,3-bisphosphoglycerate may play an important role in the control of the degradative rates of some proteins, which may explain its high concentration in certain cells.
mesh_terms: D019794:2,3-Diphosphoglycerate; D000818:Animals; D003600:Cytosol / Q000187:drug effects / Q000201:enzymology*; D004163:Diphosphoglyceric Acids / Q000494:pharmacology*; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D009954:Ornithine Carbamoyltransferase / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004163:Diphosphoglyceric Acids; D019794:2,3-Diphosphoglycerate; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D005969:Glutamate Dehydrogenase; D009954:Ornithine Carbamoyltransferase; D010447:Peptide Hydrolases