title: Design of alternate substrate inhibitors of serine proteases. Synergistic use of alkyl substitution to impede enzyme-catalyzed deacylation.
mesh_terms: D000478:Alkylation; D055598:Chemical Phenomena; D002621:Chemistry; D010450:Endopeptidases; D006801:Humans; D007962:Leukocytes / Q000201:enzymology; D010078:Oxazines / Q000138:chemical synthesis* / Q000494:pharmacology; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D011480:Protease Inhibitors; D012697:Serine Endopeptidases; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D010078:Oxazines; D011480:Protease Inhibitors; D010450:Endopeptidases; D012697:Serine Endopeptidases; D010196:Pancreatic Elastase