title: The nonenzymatic glycation of proteins and nucleic acids, their importance for the development of diabetic complications, possible molecular basis of aging and autoimmunological processes.
abstract: The formation of nonenzymatic glycation products of proteins and nucleic acids appears to be a link between chronic hyperglycaemia and long-term diabetic complications and special forms of aging during normoglycaemia. The major effects of extended glycation include cross-linking of glycated proteins, attachment of soluble proteins to extracellular glycated matrices, conformational changes of proteins followed by altered functions and immunogenicity, and abnormalities in nucleic acid functions.
mesh_terms: D000375:Aging / Q000378:metabolism*; D001323:Autoantibodies / Q000096:biosynthesis; D004247:DNA / Q000378:metabolism*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D011506:Proteins / Q000378:metabolism*
chemical_list: D001323:Autoantibodies; D011506:Proteins; D004247:DNA; D005947:Glucose