title: Mutagenicity of 4-nitrodiphenyl ether and its metabolites.
abstract: The mutagenic potential of 4-nitrodiphenyl ether (NDE) an intermediate of herbicides and an anthelmintic drug, and its reduced products (-NO, -NHOH) were investigated in the Ames test. All the three compounds were potent direct-acting base-pair and frameshift mutagens with activity order -NHOH greater than -NO greater than -NO2. The -NHOH compound has been considered to be the penultimate/ultimate mutagen.
mesh_terms: D009152:Mutagenicity Tests; D009153:Mutagens; D010647:Phenyl Ethers / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D009153:Mutagens; D010647:Phenyl Ethers; C050826:4-hydroxylaminodiphenyl ether; C050825:4-nitrosodiphenyl ether; C042446:4-nitrobiphenyl ether