title: [Immunohistochemical methods in the diagnosis and differential diagnosis of mesenchymal skin tumors].
abstract: TNM classification, including staging and grading, cannot replace histogenetic classification of mesenchymal skin tumors; moreover, histogenetic classification is the basis for correct interpretation of the morphological criteria of malignancy. Histogenetic tumor classification can be improved by special methods, such as immunohistochemical studies of routinely formalin-fixed, paraffin-embedded material; such studies are especially advantageous in tumor diagnosis. Immunohistochemical methods are also useful in classifying less well differentiated mesenchymal tumors, which otherwise would be descriptively designated as round-celled, spindle-celled, pleomorphic, myxoid, epitheloid or pericytomalike sarcomas. Moreover, further knowledge can also be acquired about tumors with characteristic structure, but uncertain histogenesis. A prerequisite for optimal results is careful comparison of the morphological findings with routine (H&E) strains and immunohistochemical reactions. Thus, overinterpretation and misinterpretation can also be avoided in artefacts which, if misinterpreted, could have grave consequences.
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D007124:Immunoenzyme Techniques; D009363:Neoplasm Proteins / Q000378:metabolism; D012509:Sarcoma / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D009363:Neoplasm Proteins
vernacular_title: Immunhistochemische Methoden bei der Diagnose und Differentialdiagnose mesenchymaler Hauttumoren.