Electronic considerations in the mutagenesis of some 4,5-bridged chrysenes.
The mutagenic activity of four 4,5-bridged chrysene derivatives, benz(a)aceanthrylene, and 5-methylchrysene was examined using histidine auxotrophic strains TA98 and TA100 of Salmonella typhimurium. All compounds showed a positive mutagenic response with both TA100 and TA98 in the presence of S-9. A correlation between the electronic character of the bridging group and mutagenic activity for the chrysene derivatives is proposed.
D001711:Biotransformation; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002911:Chrysenes / Q000138:chemical synthesis / Q000633:toxicity*; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D010616:Phenanthrenes / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
D002911:Chrysenes; D010616:Phenanthrenes