title: [Endoscopic evaluation of the effects of diacerhein and naproxen on the gastroduodenal mucosa].
abstract: The potential capacity of diacerheine (DAR), a new drug known to have no anti-prostaglandin effect and therefore a different action mechanism from the standard non-steroid anti-inflammatory drugs, to cause damage to the gastroduodenal mucosa was compared with that of a well-known NSAID, naproxene. Gastroscopic examination of 10 + 10 patients before and 4 weeks after treatment showed that DAR produced endoscopic lesions without subjective symptoms in 10% of the patients whereas naproxene produced lesions of varying size in 50%, with or without symptoms.
mesh_terms: D000880:Anthraquinones / Q000009:adverse effects*; D004384:Duodenoscopy; D004386:Duodenum; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D005773:Gastroscopy; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects*; D008297:Male; D009288:Naproxen / Q000009:adverse effects*
chemical_list: D000880:Anthraquinones; C025292:diacerein; D009288:Naproxen
vernacular_title: Valutazione endoscopica degli effetti della diacereina e del naprossene sulla mucosa gastroduodenale.