title: The pathophysiologies of substance abuse and affective disorders: an integrative model?
abstract: Substance abuse and affective disorders involve overlapping symptom complexes. The author suggests that the neurobiologies of these conditions could be related and presents a model useful in studying the pharmacologies of some of the drugs of abuse and the pathophysiology of affective disorders. This model may bridge two disciplines and render them mutually useful.
mesh_terms: D000818:Animals; D006801:Humans; D008959:Models, Neurological; D019964:Mood Disorders / Q000503:physiopathology*; D019966:Substance-Related Disorders / Q000503:physiopathology*