New perspectives on the function of coronary artery spasm in acute myocardial infarction: the thromboischemic reentry mechanism. A review of 10 years research on the pathophysiology of AMI.
Research during the last ten years into the pathophysiology of acute myocardial infarction (AMI) has made it gradually clearer that this is a phasic event. A number of independent authors have made this conclusion quite obvious. The authors of this review suggest that the alternating sequence of coronary spasm and dilatation should be described as the "thromboischemic reentry mechanism," which itself leads to waves of reperfusion, producing characteristic episodic changes in some of the parameters of AMI. The spasms are brought about by substances let loose from aggregating platelets. Metabolites released during the concomitant ischemia lead the vessel from spasm to dilatation. Following thrombolytic treatment, the 'staccato' signs of myoglobinemia disappear, because of the withdrawal of the spasmogenic products of the platelets. It could also be shown that the concentration of myoglobin in the serum as a result of the dilating effect of calcium antagonists is twice the mean maximum value that the myoglobin time curve would show without such treatment.
D000818:Animals; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use; D003329:Coronary Vasospasm / Q000097:blood / Q000503:physiopathology*; D003331:Coronary Vessels; D004359:Drug Therapy, Combination; D006801:Humans; D007262:Infusions, Intravenous; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D009211:Myoglobin / Q000097:blood; D009543:Nifedipine / Q000008:administration & dosage / Q000627:therapeutic use; D010974:Platelet Aggregation; D013300:Streptokinase / Q000008:administration & dosage / Q000627:therapeutic use; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors; D014664:Vasodilation
D002121:Calcium Channel Blockers; D009211:Myoglobin; D013300:Streptokinase; D009543:Nifedipine