title: [Pharmacokinetic research on theophylline].
abstract: Blood serum theophylline concentrations were studied in 6 volunteers and 8 patients with bronchospastic syndrome by using an enzyme immunological assay with a commercial kit "Fedesim" (USA) at intravenous and oral administration of euphylline in a dose of 5 mg/kg. The maximal concentration at intravenous injection of euphylline was reached in volunteers in 15 minutes, at oral administration--in 90 minutes, and in patients--somewhat later.
mesh_terms: D000328:Adult; D000628:Aminophylline / Q000008:administration & dosage / Q000097:blood; D001986:Bronchial Spasm / Q000097:blood / Q000188:drug therapy; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012907:Smoking; D012996:Solutions; D013607:Tablets; D013806:Theophylline / Q000097:blood*; D013997:Time Factors
chemical_list: D012996:Solutions; D013607:Tablets; D000628:Aminophylline; D013806:Theophylline
vernacular_title: Issledovanie farmakokinetiki teofillina.