title: N,N'-diallylpentobarbital: antagonism of barbital in mice and rats.
abstract: N,N'-Diallylpentobarbital (DAPB) antagonized barbital (B)-induced sleep in mice and rats. DAPB [80 mg/kg, intraperitoneal (i.p.)] reduced the barbital (350 mg/kg, i.p.)-induced sleeping time to 40% of the control in mice. Twenty, 40 and 80 mg/kg, i.p. of DAPB reduced barbital-induced sleeping time when administered 60 min prior to injection of barbital. DAPB (80 mg/kg, i.p.) also shortened barbital (250 mg/kg, i.p.)-induced sleeping time to about 70% of the control in rats. The result indicates that DAPB is an antagonist against hypnotic activity of barbital.
mesh_terms: D000818:Animals; D001462:Barbital / Q000037:antagonists & inhibitors*; D001463:Barbiturates / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D010424:Pentobarbital / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000187:drug effects; D012890:Sleep / Q000187:drug effects
chemical_list: D001463:Barbiturates; D001462:Barbital; C047654:N,N-diallylpentobarbital; C047655:N-allylpentobarbital; D010424:Pentobarbital