title: [Tolerance of different cell types for hypotonic action].
abstract: The behavior of cells with different structure of cytoskeleton was studied in the hypotonic media: protoplasts, embryonal mouse fibroblasts and transformed mouse fibroblasts (L-line). Protoplasts were most sensitive to the hypotonic media. They began to disrupt in the hypotonic medium 4:1, and in the hypotonic medium 1:7 a complete lysis of cells was observed. Transformed mouse fibroblasts were disrupted in the medium diluted 1:15, while embryonal mouse fibroblasts were not disrupted in the medium diluted 1:31. Moreover, in the hypotonic conditions an essential difference was observed between the cells studied. Embryonal mouse fibroblasts are more tolerant to the hypotonic conditions than L-cells and protoplasts. It is suggested that the cytoskeleton may define the cell tolerance in hypotonic media.
mesh_terms: D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects; D003599:Cytoskeleton / Q000187:drug effects; D004361:Drug Tolerance; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure; D007038:Hypotonic Solutions / Q000494:pharmacology*; D007739:L Cells / Q000187:drug effects / Q000648:ultrastructure; D010945:Plants, Edible; D011523:Protoplasts / Q000187:drug effects / Q000648:ultrastructure; D013997:Time Factors
chemical_list: D007038:Hypotonic Solutions
vernacular_title: Ustoĭchivost' raznykh tipov kletok k deĭstviiu gipotonii.