title: Action of calcium-binding proteins in egg maturation and fertilisation.
abstract: There is considerable evidence that calcium acts as a primary trigger for egg maturation and fertilisation in diverse phyla. Calcium regulation has been demonstrated or suggested for numerous specific events in fertilisation, including: sperm motility, the acrosome reaction, sperm-egg binding and fusion, metabolic activation of the egg, etc. However, very little is known concerning the mechanisms whereby calcium exerts its effects. Some calcium-regulated events are mediated through calmodulin and others are likely to be as well. Additionally, protein kinase C has recently been implicated in some processes related to egg maturation and activation, although the evidence presented thus far has been indirect. Other pathways dependent upon calcium but not involving either CaM or PKC have also been identified. Much more research will be required before the multiple involvement of calcium-binding proteins in egg maturation and fertilisation are clarified.
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000502:physiology*; D002147:Calmodulin / Q000502:physiology; D005260:Female; D005306:Fertilization; D009865:Oocytes / Q000166:cytology / Q000502:physiology*; D011493:Protein Kinase C / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology
chemical_list: D002135:Calcium-Binding Proteins; D002147:Calmodulin; D011494:Protein Kinases; D011493:Protein Kinase C