title: 99mTc-glucoheptonate for quantitation of differential renal function.
abstract: Differential renal function was calculated by using 99mTc-glucoheptonate (Tc-GH) in 51 patients. Computer-acquired background-corrected individual renal function was calculated by using both the 1-3-min uptake counts and the 2-4-hr delayed static counts. The degree of correlation between the two was high (r = .96). An equally high correlation was noted in 16 children who were 12 years old or younger, in 15 patients with renal size disparity greater than 60/40%, and in six patients with abnormal creatinine clearances. Ten patients had a 30-min dynamic 99mTc-DTPA study followed immediately by the injection of Tc-GH and acquisition of delayed static images 2-4 hr later. A high degree of correlation (r = .99) was seen between the 1-3-min differential function obtained by using Tc-DTPA and the 2-4-hr delayed differential function obtained by using Tc-GH. This study shows that Tc-GH is a clinically useful and valid tool for calculation of differential renal function and that Tc-GH combines many of the best aspects of Tc-DTPA and Tc-DMSA.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005069:Evaluation Studies as Topic; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D007674:Kidney Diseases / Q000000981:diagnostic imaging; D008875:Middle Aged; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D011866:Radioisotope Renography / Q000379:methods*; D013400:Sugar Acids; D013667:Technetium; D016284:Technetium Tc 99m Pentetate; D013997:Time Factors
chemical_list: D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D013400:Sugar Acids; D013667:Technetium; D004369:Pentetic Acid; C100014:technetium Tc 99m gluceptate; D016284:Technetium Tc 99m Pentetate