The prophylactic use of ticarcillin/clavulanate in the neonate.
A combination of ticarcillin and clavulanic acid (ratio 15:1) was given prophylactically to 24 newborn infants at risk of infection. Serum and urine concentrations of ticarcillin and clavulanic acid were measured after the first parenteral dose. Fifteen of 22 organisms isolated from the infants were sensitive to the drug. The pharmacokinetic profile was satisfactory and the combination was well tolerated.
D001424:Bacterial Infections / Q000517:prevention & control*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000378:metabolism / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000517:prevention & control*; D007700:Kinetics; D008297:Male; D010406:Penicillins / Q000627:therapeutic use*; D013982:Ticarcillin / Q000378:metabolism / Q000627:therapeutic use*
D002969:Clavulanic Acids; D004338:Drug Combinations; D010406:Penicillins; D019818:Clavulanic Acid; D013982:Ticarcillin