Teratogenic inborn errors of metabolism.
Most children with inborn errors of metabolism are born healthy without malformations as the fetus is protected by the metabolic activity of the placenta. However, certain inborn errors of the fetus have teratogenic effects although the mechanisms responsible for the malformations are not generally understood. Inborn errors in the mother may also be teratogenic. The adverse effects of these may be reduced by improved metabolic control of the biochemical disorder.
D000013:Congenital Abnormalities / Q000209:etiology*; D005260:Female; D005333:Fetus / Q000378:metabolism; D006801:Humans; D008431:Maternal-Fetal Exchange; D008661:Metabolism, Inborn Errors / Q000150:complications* / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications