title: Colloidal bismuth subcitrate as coated tablets: four times versus twice daily dosage in duodenal ulcer.
abstract: Forty patients with endoscopically proven duodenal ulceration have cooperated in a clinical trial to compare the ulcer healing effect of colloidal bismuth subcitrate (CBS) at standard dosage administered either twice or four times a day. No statistically significant difference was found to exist between ulcer healing in the two groups after 4 weeks (70% and 95%, respectively), and it is concluded that twice daily CBS is an effective treatment for duodenal ulcer with clear advantages as regards patient cooperation.
mesh_terms: D000328:Adult; D001729:Bismuth / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D013607:Tablets
chemical_list: D009942:Organometallic Compounds; D013607:Tablets; C002791:bismuth tripotassium dicitrate; D001729:Bismuth