title: Proton magnetic resonance (PMR) spectroscopic determination of mechlorethamine hydrochloride for injection in commercial unit doses.
abstract: A simple PMR spectroscopic method was developed for the quantitative determination of mechlorethamine hydrochloride for injection in commercial unit doses. Deuterium oxide was used as the PMR solvent and tert-butyl alcohol served as the internal standard. The mean +/- SD% recovery value of mechlorethamine hydrochloride from synthetic formulations was 99.5 +/- 0.83, with a coefficient of variation of 0.83%. The mean content of mechlorethamine hydrochloride in a group of ten commercial unit doses was 99.3% by the PMR method and 99.4% by the titrimetric method of U. S. P. XX.
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007275:Injections, Intravenous; D009682:Magnetic Resonance Spectroscopy; D008466:Mechlorethamine / Q000008:administration & dosage / Q000032:analysis*; D012996:Solutions
chemical_list: D012996:Solutions; D008466:Mechlorethamine