title: [Pharmacological analysis of the anticonvulsant action of kavinton].
abstract: In experiments on rats it was found that cavinton administered in doses of 1-30 mg/kg exerted a distinct dose-dependent anticonvulsant effect, according to the test of maximal electroshock, not less than that of phenobarbital, difenin and carbamazepine. Combined use of cavinton and these drugs potentiated its anticonvulsant action. The involvement of noradrenergic systems, in particular, alpha 1-adrenoceptors, in the anticonvulsant effect of cavinton is suggested.
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004597:Electroshock; D005260:Female; D008297:Male; D051381:Rats; D013997:Time Factors; D014748:Vinca Alkaloids / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D014748:Vinca Alkaloids; C013983:vinpocetine
vernacular_title: Farmakologicheskiĭ analiz protivosudorozhnogo deĭstviia kavintona.