title: Improved synthetic inactivators of plasmin.
abstract: Synthetic inhibitors for plasmin of the peptidyl chloromethyl ketone type are described which have increased effectiveness due to side-chains which improve affinity to auxiliary binding regions of the active center.
mesh_terms: D000590:Amino Acid Chloromethyl Ketones / Q000494:pharmacology; D000933:Antifibrinolytic Agents / Q000138:chemical synthesis*; D006801:Humans; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000590:Amino Acid Chloromethyl Ketones; D000933:Antifibrinolytic Agents; D011480:Protease Inhibitors