Hypercalcaemia in "non-secretory" myeloma.
A patient is described with hypercalcaemia due to myelomatosis without paraproteinaemia or Bence-Jones proteinuria. Immunological investigations yielded some evidence of intra-cellular immunoglobulin production. Histological features suggested the secretion of osteoclast activating factor. Relevant experimental work in support of this interpretation is reviewed.
D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008222:Lymphokines / Q000378:metabolism; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*
D008222:Lymphokines; C008718:osteoclast activating factor