Blockade of ovulation by prostaglandins synthesis inhibitor in medial preoptic area.
Indomethacin, a known inhibitor of prostaglandins synthesis, injected into the medial preoptic area on the day of proestrus blocked ovulation in regularly cycling female rats. This finding provides evidence for a facilitatory role of endogenous prostaglandin synthesis, in the medial preoptic area, in the process of ovulation.
D000818:Animals; D001931:Brain Mapping; D003864:Depression, Chemical; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000378:metabolism; D010060:Ovulation / Q000187:drug effects; D011301:Preoptic Area / Q000187:drug effects / Q000502:physiology*; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D011453:Prostaglandins; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D007213:Indomethacin