title: Volume/pressure curve of total respiratory system in paralysed patients: artefacts and correction factors.
abstract: The volume/pressure (V/P) curve of the total respiratory system in paralysed patients is drawn assuming that volume changes of the respiratory system (delta V resp) equals volume displacement of the measuring apparatus (delta V syr), usually a supersyringe. However, in 93 VP curves we found that O2 removed from the lung-syringe system during the procedure (proportional to the time) largely exceeds the CO2 added to the lung-syringe system (delta V gas). This results in a net loss of volume from the system (delta V resp less than delta V-syr). Deflation compliance, hysteresis area and ratio are significantly affected by this phenomenon. Inflation compliance is less influenced by delta V gas, partially compensated by the intrapulmonary gas expansion due to the temperature changes. We conclude that the parameters computed on the deflation limb of V/P curve are misleading if proper correction of the volume scale is not introduced.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008170:Lung Compliance; D008875:Middle Aged; D010243:Paralysis / Q000150:complications / Q000503:physiopathology*; D011312:Pressure; D011659:Pulmonary Gas Exchange; D012123:Pulmonary Ventilation; D012131:Respiratory Insufficiency / Q000209:etiology / Q000503:physiopathology; D012137:Respiratory System / Q000503:physiopathology*; D013696:Temperature