HMP-shunt and cholesterol metabolism in experimental models involving normal and preneoplastic liver growth.
Previous studies from our laboratories have shown a stimulation of HMP-shunt, cholesterol metabolism and DNA synthesis during cell proliferation. In order to understand the co-ordinated regulation of these pathways during cell growth, the above metabolic pathways were studied in: liver regeneration after partial hepatectomy, lead-induced liver hyperplasia, liver cell proliferation induced by insulin in streptozotocin-diabetic rats, liver cell proliferation in fasted rats after refeeding and, hepatocyte nodules induced by a selection procedure. The results indeed indicate that changes in HMP-shunt and cholesterol metabolism occur at a very early stage during the process of normal as well as preneoplastic cell growth. The coordinated regulation between cell growth and changes in these metabolic pathways needs further study.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism; D004052:Diethylnitrosamine; D005215:Fasting; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006498:Hepatectomy; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D007854:Lead; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism*; D008115:Liver Regeneration; D008297:Male; D009566:Nitrates; D009929:Organ Size / Q000187:drug effects; D010427:Pentose Phosphate Pathway; D011230:Precancerous Conditions / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D009566:Nitrates; D007854:Lead; D004052:Diethylnitrosamine; C017461:lead nitrate; D002784:Cholesterol; D005954:Glucosephosphate Dehydrogenase