title: Glucose metabolism after pancreas transplantation.
abstract: After pancreas transplantation in type-I diabetics the dependency on exogenous insulin usually vanishes rapidly. In about 50% of patients fasting and postprandial blood glucose concentrations are normal but by oral glucose tolerance tests the glucose metabolism is classified as normal in a minority. Some of the reasons for failure in obtaining good metabolic control are discussed. Attention is focused on the inevitable peripheral hyperinsulinemia and concomitant portal hypoinsulinemia related to the extra-portal administration of insulin.
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism; D016035:Pancreas Transplantation; D012039:Regional Blood Flow
chemical_list: D007328:Insulin; D005947:Glucose