[Influence of prostaglandin synthesis blockade on the immunosuppressive effect of serotonin and haloperidol].
Administration of indomethacin (1.5 and 10 mg/kg) to CBA mice was found to produce a considerable increase of the number of plaque- and rosette-forming cells irrespective of the dose and the interval between its injection and immunization of the mice with ram erythrocytes (5 X 10(6)). The immunogenesis stimulation preserved in the mice after a lesion of the pituitary peduncle. Indomethacin was shown to prevent a decrease of the immune response produced by administration of serotonin (50 mg/kg) and haloperidol (1 mg/kg).
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D006462:Hemolytic Plaque Technique; D007114:Immunization; D007166:Immunosuppressive Agents; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D012397:Rosette Formation; D012701:Serotonin / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D007166:Immunosuppressive Agents; D011448:Prostaglandin Antagonists; D012701:Serotonin; D006220:Haloperidol; D007213:Indomethacin
Vliianie blokady sinteza prostaglandinov na immunosuppressivnyĭ éffekt serotonina i galoperidola.