Immune-mediated hemolytic anemia and thrombocytopenia in a foal.
A one-month-old Quarter Horse filly had unilateral epistaxis, hyphema, icterus, petechial hemorrhages in the oral, nasal, conjunctival, and vulvar mucous membranes, anemia, thrombocytopenia, negative antinuclear test result, and a positive direct Coombs' test result. Megakaryocytes or cell-associated IgG (fluorescent antibody and immunoperoxidase stains) were not found in bone marrow biopsy specimens. Treatment consisted of glucocorticoids, antibiotics, and a single whole blood transfusion. The foal responded well to treatment, did not develop relapses of the disease, and was clinically normal one year after treatment.
D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000662:veterinary*; D000818:Animals; D005260:Female; D006734:Horse Diseases; D006736:Horses; D013921:Thrombocytopenia / Q000150:complications / Q000662:veterinary*