High plasma cholecystokinin levels in patients with chronic pancreatitis having abdominal pain.
Plasma cholecystokinin (CCK) responses after ingestion of a test meal in patients with mild chronic pancreatitis having abdominal pain were studied with a radioimmunoassay using the CCK specific antiserum (OAL-656) produced by a novel immunization procedure. Mean concentration of the fasting plasma CCK determined using CCK-8 as a standard was 31.5 +/- 5.8 pg/ml in six patients who had mild impaired exocrine function with pain, and was significantly higher than 10 healthy subjects (9.8 +/- 1.8 pg/ml). In those patients, the ingestion of a liquid test meal led to a peak of 75.1 +/- 25.4 pg/ml at 30 min, and the 120-min integrated CCK response (5427 +/- 1217.3 pg X min/ml) was significantly higher than in healthy subjects (1538 +/- 110.1 pg X min/ml).
D000005:Abdomen; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002766:Cholecystokinin / Q000097:blood*; D002908:Chronic Disease; D005215:Fasting; D005246:Feedback; D005260:Female; D005502:Food; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology*; D010179:Pancreas / Q000503:physiopathology; D010182:Pancreatic Diseases / Q000097:blood* / Q000150:complications; D010191:Pancreatic Polypeptide / Q000097:blood; D011863:Radioimmunoassay
D001786:Blood Glucose; D007328:Insulin; D010191:Pancreatic Polypeptide; D002766:Cholecystokinin