title: Reconstruction of the mandible with autogenous bone following treatment for squamous carcinoma.
abstract: In a series of 24 patients treated for squamous carcinoma of the oral cavity and oropharynx, 26 mandibular reconstructions using 27 grafts or flaps were performed. Reconstruction was immediate in 23 cases and delayed in three. There were five 'simple' bone grafts, 10 pedicled compound myocutaneous flaps, and 12 vascularized free compound flaps. Operative mortality was 12% and complication rate 65%, but 70% of the grafts survived till death or follow-up of the patients. Three 'simple' bone grafts failed and were removed. Three of five compound pectoralis major flaps failed along with one of five pedicled compound latissimus dorsi flaps. Only one vascularized free compound flap was lost. The major cause of graft failure was intra-oral suture line dehiscence exposing the bone to saliva. Under these circumstances, bone graft necrosis occurred when blood supply to the bone was poor--viz. 'simple' grafts and compound pectoralis major flaps. The vascularized free compound flaps were most reliable but the need for jaw preservation where possible and better patient selection are recognized.
mesh_terms: D000328:Adult; D000368:Aged; D016025:Bone Transplantation; D002294:Carcinoma, Squamous Cell / Q000534:rehabilitation* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000601:surgery*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000534:rehabilitation* / Q000601:surgery; D009959:Oropharyngeal Neoplasms / Q000534:rehabilitation* / Q000601:surgery; D010610:Pharyngeal Neoplasms / Q000534:rehabilitation*; D011183:Postoperative Complications; D011859:Radiography; D011877:Radionuclide Imaging; D013524:Surgical Flaps