Lipid alterations induced by nifurtimox in Trypanosoma cruzi.
The influence of growth in the presence of nifurtimox on total lipids of Trypanosoma cruzi epimastigotes was determined. Nifurtimox-treated organisms showed greater amounts of unsaturated fatty acids as compared with control cells. 18:2 was the major component in the total esterified lipid fraction. Similar results were observed on the free fatty acid composition as detected by trimethylsilyl derivatization of the total lipids.
D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D050356:Lipid Metabolism; D009547:Nifurtimox / Q000494:pharmacology*; D009581:Nitrofurans / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D005231:Fatty Acids, Unsaturated; D009581:Nitrofurans; D009547:Nifurtimox