title: Lung reflexes affecting the larynx in the pig, and the effect of pulmonary microembolism.
abstract: Laryngeal airflow resistance was measured in anaesthetized pigs during stimulation of lung vagal reflexes by injection of phenylbiguanide and of capsaicin, before and during pulmonary microembolism due to intravenous injection of hardened red blood cells; the microembolism caused pulmonary hypertension. The Breuer-Hering reflex was also assessed before and after pulmonary microembolism. Phenylbiguanide and capsaicin caused apnoea followed by rapid shallow breathing, hypertension, bradycardia and laryngeal constriction in inspiration and expiration. Most of these effects were abolished by bilateral cervical vagotomy. Pulmonary microembolism caused only small changes in breathing pattern, mainly a decrease in inspiratory time. After microembolism the Breuer-Hering reflex was enhanced, and injections of phenylbiguanide and capsaicin caused longer apnoeas by a vagal reflex. The changes in pattern of breathing and in lung reflexes after lung microembolism and during the associated pulmonary hypertension are consistent with an enhancement of pulmonary stretch receptor activity in this condition, but do not indicate any important role for C fibre reflexes.
mesh_terms: D000818:Animals; D001645:Biguanides / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007830:Larynx / Q000502:physiology* / Q000503:physiopathology; D008168:Lung / Q000502:physiology* / Q000503:physiopathology; D011655:Pulmonary Embolism / Q000503:physiopathology*; D012018:Reflex; D013552:Swine; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D001645:Biguanides; D002211:Capsaicin; C008846:phenyl biguanide