Preliminary observations on interaction of 14C-metronidazole with macromolecules in vivo and in vitro.
Preliminary studies on the in vivo and in vitro interactions of 14C-metronidazole with macromolecules showed that the agent or its metabolite(s) can interact with nucleic acids and proteins in vivo. In vitro studies suggest that in absence of DNA synthesis trace amount of metronidazole does bind to DNA/protein and addition of metabolic activation system (from mouse liver) generates more reactive species from metronidazole.
D000818:Animals; D002250:Carbon Radioisotopes; D004247:DNA / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008795:Metronidazole / Q000378:metabolism*; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D011247:Pregnancy; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*
D002250:Carbon Radioisotopes; D011506:Proteins; D008795:Metronidazole; D004247:DNA