Time-dependent effects of papaverine on electrically induced seizures in rats.
We tested the effects of papaverine, an adenosine uptake blocker, on hippocampal-elicited afterdischarges in rats. Rats were injected with 35 mg/kg papaverine and tested for seizure responses at 5, 20, and 60 min postinjection. Papaverine produced a potent inhibition of afterdischarge generation, greatly reduced afterdischarge duration, and blocked hippocampal-kindled seizures. This anticonvulsant effect was greatest 5 min postinjection and had largely dissipated by 60 min. Because papaverine also produced a Parkinson-like syndrome involving muscle rigidity, these results are discussed in terms of effects on dopamine and adenosine systems.
D000241:Adenosine / Q000378:metabolism; D000679:Amygdala / Q000187:drug effects; D000818:Animals; D000927:Anticonvulsants; D006624:Hippocampus / Q000187:drug effects; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D010208:Papaverine / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D012640:Seizures / Q000517:prevention & control*
D000927:Anticonvulsants; D011954:Receptors, Dopamine; D010208:Papaverine; D000241:Adenosine