[Pharmacological effects of combinations of psychotropic preparations used in combined pharmacotherapy].
It was shown in experiments on mice that inhibition of the exploratory activity by ftoracizin, phenazepam, scopolamine hydrobromide and their combinations predominates in comparison with muscle relaxation. Phenazepam administered at the low dose (0.025 mg/kg) by its depressive effect on the central nervous system was an antagonist of ftoracizin and a synergist of scopolamine. Ftoracizin and scopolamine show a mutual dose-effects-dependent antagonism in the inhibitory action and acute toxicity (LD50).
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009126:Muscle Relaxation / Q000187:drug effects; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000633:toxicity
D011619:Psychotropic Drugs
Farmakologicheskie éffekty kombinatsiĭ nekotorykh piskhotropnykh preparatov, primeniaemykh v kompleksnoĭ farmakoterapii.