title: Therapeutic activity of lactate 12% lotion in the treatment of ichthyosis. Active versus vehicle and active versus a petrolatum cream.
abstract: Lactate 12% lotion was significantly more effective than both its vehicle and a petrolatum-based cream in the treatment of ichthyosis. The treatment regimen was twice-daily application for 4 weeks with evaluations weekly during the treatment period and for 2 weeks after treatment was stopped. Vulgaris, lamellar, sex-linked, Netherton's, and epidermolytic hyperkeratotic forms of ichthyosis were significantly improved by treatment with lactate 12% lotion. This new therapeutic modality expands the scope and extent of ichthyotic conditions that may now be successfully treated.
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D006801:Humans; D007057:Ichthyosis / Q000188:drug therapy* / Q000235:genetics; D007773:Lactates / Q000627:therapeutic use*; D019344:Lactic Acid; D008875:Middle Aged; D010577:Petrolatum / Q000627:therapeutic use*; D014677:Pharmaceutical Vehicles
chemical_list: D007773:Lactates; D014677:Pharmaceutical Vehicles; D019344:Lactic Acid; D010577:Petrolatum