Captopril reduces renal excretion of prostaglandin E2 in the sodium-depleted rabbit.
The effects of captopril on renal function and prostaglandin E2 excretion were investigated in rabbits undergoing chronic sodium depletion. Captopril administered for six days, via rate-controlled osmotic pumps, caused diuresis and marked natriuresis which were accompanied by a significant reduction of urinary prostaglandin E2 excretion and of glomerular filtration rate. It is concluded that captopril reduces the renal excretion of prostaglandin E2 and that its diuretic and natriuretic effects are prostaglandin E2-independent.
D000818:Animals; D002216:Captopril / Q000494:pharmacology*; D004039:Diet, Sodium-Restricted; D015232:Dinoprostone; D007677:Kidney Function Tests; D008297:Male; D011458:Prostaglandins E / Q000652:urine*; D011817:Rabbits; D012964:Sodium / Q000502:physiology* / Q000652:urine
D011458:Prostaglandins E; D002216:Captopril; D012964:Sodium; D015232:Dinoprostone