title: Jogging causes a significant increase in platelet sensitivity to prostacyclin.
abstract: Platelet function and platelet sensitivity to PGI2 was studied before and after jogging in seven males and four females in good health. The ADP-induced (1 microM) aggregation, being always increased after physical activity, showed during the entire follow-up period of 12 months a significant decrease at rest and after exercise compared with baseline values. The change in the aggregation response was significant for t alpha at month 1 and for delta tmax at month 2 after starting the jogging. The platelet sensitivity to PGI2, being always diminished after exercise, also increased significantly during the entire follow-up period compared with baseline levels. In contrast to the ADP-induced changes, the changes in platelet sensitivity were significant already at week 2. Our findings indicate that daily physical activity causes a significant improvement in platelet function and reduces platelet activation.
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D011464:Epoprostenol / Q000502:physiology*; D005260:Female; D006487:Hemostasis; D006801:Humans; D007590:Jogging; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011446:Prospective Studies; D012420:Running
chemical_list: D000244:Adenosine Diphosphate; D011464:Epoprostenol