[Immunohistological observation of blood group-related antigens in lung adenocarcinomas using monoclonal antibodies].
The immunohistological distribution of blood group (BG)-related antigens including A, B, H type 2, and sialylated Lex in lung adenocarcinomas was examined using monoclonal antibodies. BG-A, B, and H type 2 compatible with the ABO status in tumor cells were expressed in 60% of the cases. Accumulation of H type 2, associated with loss of BG-A and B, was observed in tumor cells of patients with BG status other than 0. Tumor-associated antigens, Lex and sialylated Lex were detected in 36.0% and 72.0%, respectively. Modification of carbohydrate antigens in cancer may be associated with incomplete synthesis; accumulation of precursor antigen; and activated sialylation.
D000017:ABO Blood-Group System / Q000276:immunology; D000230:Adenocarcinoma / Q000276:immunology*; D000911:Antibodies, Monoclonal; D001789:Blood Group Antigens / Q000276:immunology*; D006801:Humans; D007519:Isoantigens / Q000032:analysis*; D008175:Lung Neoplasms / Q000276:immunology*
D000017:ABO Blood-Group System; D000911:Antibodies, Monoclonal; D001789:Blood Group Antigens; D007519:Isoantigens