Mutagenicity of bithionol sulfoxide and its metabolites in the salmonella/mammalian microsome test.
The mutagenic effects of bithionol sulfoxide and its two major metabolites, bithionol and bithionol sulfone, on 4 Salmonella typhimurium strains (TA97, TA98, TA100 and TA102) were investigated. Bithionol sulfoxide was found to be mutagenic to TA98 and TA100. However, mutagenicity was abolished in the presence of rat-liver S9 fractions.
D000818:Animals; D001711:Biotransformation; D001735:Bithionol / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D008658:Inactivation, Metabolic; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D010636:Phenols / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects*
D010636:Phenols; C030608:oxichloron; C000297:bithionol sulfoxide; D001735:Bithionol