Antenatal assessment of fetal outcome in pregnant diabetics.
The predictive value of three parameters (amniotic fluid insulin and C-peptide, and HbA1) in prognosticating major neonatal symptomatology was investigated in 57 pregnancies of diabetic women. The prediction of a healthy neonate can be achieved with a 90% accuracy by measurement of the amniotic fluid insulin alone. The correct prognosis for a child with major neonatal problems due to maternal diabetes can be made with 70% certainty using the same method. All other parameters can be judged less valuable based on our results. By using more than one of those parameters mentioned, the prediction of a healthy child can be made more correctly with a certainty of almost 100%. The accuracy in predicting a child with major symptoms cannot be increased any further.
D000653:Amniotic Fluid / Q000032:analysis; D002096:C-Peptide / Q000032:analysis; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis*; D007328:Insulin / Q000032:analysis; D011247:Pregnancy; D011254:Pregnancy in Diabetics; D011296:Prenatal Diagnosis; D011379:Prognosis
D002096:C-Peptide; D006442:Glycated Hemoglobin; D007328:Insulin