[Serum level of antibiotics in burn patients].
Antibiotic serum levels were recorded from 100 patients with burns. Antibiotic doses to ensure effective serum levels were found to be in excess of maximum values quoted as necessary by manufacturers, provided that serum creatinine was normal. These findings were in agreement with literature data. This was the first instance to check on serum levels, following oral administration of antibiotics. Differences between individual patients may be considerable, probably due to variable renal blood supply and other factors. Individual dosage with control of serum levels is, therefore, recommended. Specific dosage recommendation for patients with burns would be desirable for hospital practice.
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000097:blood* / Q000627:therapeutic use; D002056:Burns / Q000097:blood* / Q000188:drug therapy; D002442:Ceftazidime / Q000097:blood; D002506:Cephalexin / Q000097:blood; D005839:Gentamicins / Q000097:blood; D006801:Humans; D007700:Kinetics; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010068:Oxacillin / Q000097:blood; D014031:Tobramycin / Q000097:blood
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002442:Ceftazidime; D002506:Cephalexin; D010068:Oxacillin; D014031:Tobramycin
Der Serumspiegel von Antibiotika bei Brandverletzten.