The effect of purified aminoaldehydes produced by polyamine oxidation on the development in vitro of Plasmodium falciparum in normal and glucose-6-phosphate-dehydrogenase-deficient erythrocytes.
Purified aminoaldehydes produced by polyamine oxidation were toxic to the malarial parasite, Plasmodium falciparum, cultured in human erythrocytes. There was a profound effect on young ring forms, and, during maturation, parasites became more sensitive to the aldehydes. Oxidation of the aldehydes abolished the lethal effect. The plasmodia within glucose-6-phosphate-dehydrogenase (G6PD)-deficient erythrocytes were more sensitive to mono- and di-aldehydes than were parasites in normal erythrocytes. G6PD-deficient erythrocytes were also more sensitive to pretreatment with the dialdehyde produced by the oxidation of spermine. Pretreatment prevented further invasion by the parasites.
D000447:Aldehydes / Q000494:pharmacology*; D003959:Diamines / Q000494:pharmacology*; D004912:Erythrocytes / Q000469:parasitology*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000469:parasitology*; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D011437:Propylamines / Q000494:pharmacology*; D013096:Spermine / Q000031:analogs & derivatives*
D000447:Aldehydes; D003959:Diamines; D007042:Hypoxanthines; D011437:Propylamines; C050864:N,N'-bis(3-propionaldehyde)-1,4-diaminobutane; D013096:Spermine; D019271:Hypoxanthine; C050863:N'-(4-aminobutyl)-3-aminopropionaldehyde; C050862:3-aminopropionaldehyde