[Ultrastructural changes in cells of the white pulp of the spleen during experimental salmonella infection].
The electron microscopic investigation of the immuno-competent cells in various zones of the spleen has revealed certain subcellular bases of the organ's reaction to the experimental salmonellosis. Alterations at early stage of the experiment (3-24 h after infection with Salmonella) are predominantly of destructive character: pyknosis of nuclei, dilated cisterns of the karyotheca, lysis of crests in mitochondria of some cells. On the 3d-14th day hyperplasia and hypertrophy of organelles in the immune-competent cells are revealed; it is connected with increasing processes of immunogenesis. At late stages of the investigation, normalization of the spleen cells ultrastructure and increased functional fibroblastic activity are noted.
D000818:Animals; D002196:Capillaries / Q000648:ultrastructure; D008214:Lymphocytes / Q000648:ultrastructure; D008264:Macrophages / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009940:Organoids / Q000648:ultrastructure; D010950:Plasma Cells / Q000648:ultrastructure; D051381:Rats; D012481:Salmonella Infections, Animal / Q000473:pathology*; D012486:Salmonella typhimurium; D013154:Spleen / Q000648:ultrastructure*
Ul'trastrukturnye izmeneniia kletok beloĭ pul'py selezenki pri éksperimental'noĭ sal'monelleznoĭ infektsii.