Amino-sugars inhibit the in vitro cytoadherence of Plasmodium falciparum-infected erythrocytes to melanoma cells.
Twenty-two sugars and related compounds, nine neoglycoproteins, dopamine, four polyamines and oligomers of glucosamine were examined for their effect on the cytoadherence of Plasmodium falciparum-infected erythrocytes to melanoma cells. Inhibition of cytoadherence was high in the presence of the amino-sugars, glucosamine, galactosamine and mannosamine, and dopamine, and significant, although lower, in the presence of the polyamines, spermine, spermidine and putrescine. N-acetylated amino-sugars and the other compounds were not significant inhibitors of cytoadherence.
D000606:Amino Sugars / Q000494:pharmacology*; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D004912:Erythrocytes / Q000187:drug effects / Q000469:parasitology* / Q000502:physiology; D005260:Female; D005944:Glucosamine / Q000494:pharmacology; D006801:Humans; D008545:Melanoma; D010963:Plasmodium falciparum / Q000502:physiology*; D011073:Polyamines / Q000494:pharmacology; D012453:Saimiri
D000606:Amino Sugars; D011073:Polyamines; D005944:Glucosamine