Neurotensin in the human fallopian tube: immunohistochemical localization and effects of synthetic neurotensin on motor activity in vitro.
With the use of different region-specific antisera and the peroxidase-antiperoxidase (PAP) technique, neurotensin-immunoreactivity was found in nerve fibers of the human fallopian tube. Neurotensin-immunoreactive fibers occurred at blood vessels and in contact with smooth muscle cells of the muscular stratum. In vitro experiments with helical strips of the myometrium revealed dose-dependent excitatory actions of neurotensin on resting tension as well as on amplitude and frequency of spontaneous contractions. The results may suggest a neurotransmitter function of neurotensin in the regulation of human oviductal smooth muscle activity. Thus, neurotensin may be essential in the transport of the eggs through the fallopian tube.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D005187:Fallopian Tubes / Q000187:drug effects / Q000294:innervation* / Q000502:physiology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D009412:Nerve Fibers / Q000378:metabolism*; D009496:Neurotensin / Q000378:metabolism* / Q000494:pharmacology
D009496:Neurotensin