Cytoprotective agents in experimental small bowel volvulus.
An accepted experimental model for midgut volvulus was used to produce small bowel strangulation obstruction of 48 hours duration in Sprague-Dawley rats. A 93% perioperative mortality rate resulted after release of the volvulus. Treatment with three cytoprotective agents at the time of volvulus release resulted in the following mortality rates: superoxide dismutase, 89%; ibuprofen, 50%; prostaglandin E1 (PGE1, 11%. The predominant cause of death in all treatment groups was bowel infarction, with a smaller number succumbing to either sepsis or circulatory collapse. Concomitant administration of ephedrine or indomethacin to suppress prostaglandin E1's splanchnic vasodilatory activity did not cause any increase in mortality. A trial of aspirin, to simulate PGE's antiplatelet actions, showed no reduction in mortality when compared with detorsion alone. Prostaglandin E1 and, to a lesser extent, ibuprofen, appear to have cytoprotective effects during reperfusion of bowel compromised by volvulus, independent of their influence on the mesenteric vasculature and thrombogenesis.
D000527:Alprostadil / Q000627:therapeutic use; D000818:Animals; D001241:Aspirin / Q000627:therapeutic use; D004809:Ephedrine / Q000627:therapeutic use; D007052:Ibuprofen / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use; D007415:Intestinal Obstruction / Q000188:drug therapy* / Q000473:pathology; D007421:Intestine, Small; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000627:therapeutic use
D013482:Superoxide Dismutase; D000527:Alprostadil; D004809:Ephedrine; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin