title: [Efficacy of a graded plan for long-term prevention using antihypertensive drugs. Work Group for the Cooperative Study for the Testing of New Preparations for the Prevention of Arterial Hypertension (CSPPAH)].
abstract: Data on the efficiency of stepwise long-term preventive medication with antihypertensive agents are presented. The stepwise regimen of antihypertensive medication produced at least a short-term hypotensive effect (more than month) in 93.5% of patients within 1 year, with complete arterial BP normalization in 67.7% and partial effect in another 25.8%. Stable effect (more than 6 months) was however achieved in 1/5 of patients only. Side effects associated with this regimen were seen in 19.4% of patients. Since the effect persisted for more than 2 months in 52.6% of patients only, and was only stable (over 6 months) in one-fifth, follow-up examination of patients with arterial hypertension should be made at least once a month to allow assessment of the efficiency and safety of medication.
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D003971:Diastole; D004359:Drug Therapy, Combination; D006339:Heart Rate; D006801:Humans; D006830:Hydralazine / Q000627:therapeutic use; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D013599:Systole
chemical_list: D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D006830:Hydralazine; D011433:Propranolol; D011224:Prazosin
vernacular_title: Effektivnost' stupenchatoĭ skhemy dlitel'noĭ medikamentoznoĭ profilaktiki antigipertenzivnymi sredstvami. Rabochania gruppa kooperativnogo issledovaniia po izucheniiu novykh preparatov v profilaktike arterial'noĭ gipertenzii (KIPPAG).