Adrenal schwannoma with apparent uptake of immunoglobulins.
Schwannoma, a rare tumor of the adrenal gland, was an incidental finding in a 63-year-old woman who had no endocrine symptoms. In addition to the usual light and electron microscopic and immunohistochemical features of a schwannoma, the tumor contained large granular cells and a stroma rich in lymphocytes and plasma cells. The tumor cells appeared on ultrastructural examination to incorporate proteinaceous material by endocytosis into large lysosomal bodies and on immunocytologic studies; the presence of immunoglobulins was noted within the cytoplasm. The apparent massive uptake of immunoglobulins by tumor cells suggests a direct interaction between host and the tumor.
D000310:Adrenal Gland Neoplasms / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure*; D004705:Endocytosis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000378:metabolism*; D008854:Microscopy, Electron; D008875:Middle Aged; D009442:Neurilemmoma / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure*
D007136:Immunoglobulins