Comparison of two formulations of lignocaine spray with mefenamic acid in the relief of post-episiotomy pain: a placebo-controlled study.
The analgesic effectiveness of aqueous and alcoholic formulations of lignocaine (5%) spray was compared with that of mefenamic acid (500 mg) or placebo in a double-blind study in 103 primiparous patients complaining of moderate or severe perineal pain associated with episiotomy. The results, assessed after a single dose, showed that the aqueous lignocaine formulation provided a level of pain relief superior to that obtained with the alcoholic formulation or placebo, and similar to that obtained with mefenamic acid.
D000328:Adult; D000336:Aerosols; D000698:Analgesia / Q000379:methods*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004841:Episiotomy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008528:Mefenamic Acid / Q000008:administration & dosage*; D010149:Postoperative Pain / Q000188:drug therapy*; D049590:Postpartum Period; D011247:Pregnancy; D011897:Random Allocation; D013607:Tablets; D013997:Time Factors
D000336:Aerosols; D013607:Tablets; D008528:Mefenamic Acid; D008012:Lidocaine