[The problem of peroxidation in radiobiology].
A hypothesis is validated concerning the products of free radical oxidation of lipids and the phenol compounds as a mediator unit of the stress-syndrome. The data are reviewed on activation of peroxidation under the effect of radiation, cytochemical agents, etc., secondarily stimulating the neurohumoral system function of homeostasis regulation. With the emotional-algesic and cold-stresses, the regulatory system stimulation is of primary, reflex, nature, but it secondarily promotes the peroxidation activation. The radiotoxins (of the quinoid and lipid nature) appearing in tissues under the effect of ionizing radiation, are similar in structure and mechanism of action to peroxidation activation products formed under the effect of other stress-agents.
D000818:Animals; D005609:Free Radicals; D010545:Peroxides / Q000096:biosynthesis*; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D014118:Toxins, Biological / Q000096:biosynthesis
D005609:Free Radicals; D010545:Peroxides; D014118:Toxins, Biological
Problema perekisnogo okisleniia v radiobiologii.