[Characteristics of hematopoiesis regeneration in subcutaneous bone implants in aging mice].
Femurs from both young and old mice were implanted subcutaneously to young syngeneic recipients. 2-2.5 months after surgery femoral marrow grafts were repopulated with nucleated cells and macrophage-granulocyte precursor cells irrespective of the donor's age. Marrow depletion of femurs prior to implantation caused a sharp decrease in hemopoietic repopulation of implants from old, but not young, donors. It is concluded that age-dependent functional peculiarities of stromal microenvironment can be visualized owing to the extraordinary local regenerative demand.
D000375:Aging / Q000502:physiology*; D000818:Animals; D001853:Bone Marrow / Q000502:physiology*; D016025:Bone Transplantation; D003114:Colony-Forming Units Assay; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA
Osobennosti vosstanovleniia krovetvoreniia v podkozhnykh implantatakh kosti u mysheĭ pri starenii.