title: Genotype-influenced changes in serum HDL cholesterol after short-term overfeeding in man: association with plasma insulin and triglyceride levels.
abstract: Six pairs of male monozygotic (MZ) twins were submitted to a 22-day overfeeding period during which they ingested a daily surplus of 1,000 kcal above their individual daily energy needs in the form of a mixed diet. Serum lipids, lipoproteins, and apoprotein A and B concentrations were measured before and after the overfeeding period. Percentage of body fat, fasting plasma glucose, and insulin levels as well as plasma glucose and insulin concentrations after a glucose challenge were also measured before and after overfeeding. Results showed that before overfeeding, MZ twins exhibited a significant intrapair resemblance for total serum cholesterol (CHOL), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), and for the high density lipoprotein-cholesterol/total cholesterol ratio (HDL-C/CHOL) (8.2 less than or equal to F ratios less than or equal to 32.7, P less than .01). The overfeeding experiment induced significant increases only in serum CHOL (P less than .01) and in serum LDL-C (P less than .05). However, although mean group values of serum TG, HDL-C, and HDL-C/CHOL ratio were not significantly modified by overfeeding, there were large interindividual variations in the response of these variables to the experiment. Results suggest that changes in serum TG, HDL-C, and in the HDL-C/CHOL ratio were significantly associated with the genotype of the subjects as a significant intrapair resemblance in the response to overfeeding was observed for these variables (0.69 less than or equal to r less than or equal to .85, P less than .05).(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D001068:Feeding and Eating Disorders / Q000097:blood*; D005838:Genotype; D005951:Glucose Tolerance Test; D006801:Humans; D006963:Hyperphagia / Q000097:blood*; D007328:Insulin / Q000097:blood*; D008297:Male; D014280:Triglycerides / Q000097:blood*; D014430:Twins, Monozygotic
chemical_list: D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D014280:Triglycerides