HLA phenotypes and bullous cutaneous reactions to drugs.
Drug induced toxic epidermal necrolysis and Stevens-Johnson syndrome are weakly associated with HLA-B12. Among patients reacting to a given drug we observed stronger links, especially for HLA-A29; B12; DR7 and sulphonamides.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002648:Child; D004198:Disease Susceptibility; D005260:Female; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens / Q000235:genetics; D015809:HLA-DR7 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000276:immunology; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced / Q000276:immunology; D013449:Sulfonamides / Q000009:adverse effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006680:HLA Antigens; D015234:HLA-A Antigens; C035524:HLA-A29 antigen; D015235:HLA-B Antigens; C035015:HLA-B12 antigen; D006684:HLA-DR Antigens; D015809:HLA-DR7 Antigen; D013449:Sulfonamides