title: Randomized phase III trial of single versus multiple chemotherapeutic treatment following surgery and during radiotherapy for patients with anaplastic gliomas.
abstract: In 81 patients with anaplastic supratentorial gliomas, single versus multiple chemotherapeutic agents were selected for treatment following surgery and during radiotherapy in a prospective randomized study. Time to treatment failure and survival were not significantly enhanced by multiple agent chemotherapy, as administered in this study.
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D002330:Carmustine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005910:Glioma / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D008936:Mitolactol / Q000627:therapeutic use; D011344:Procarbazine / Q000627:therapeutic use; D011897:Random Allocation; D013713:Teniposide / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D011344:Procarbazine; D013713:Teniposide; D008936:Mitolactol; D002330:Carmustine; D008775:Methylprednisolone; D006918:Hydroxyurea