title: [Changes in the pharmacodynamic properties of promedol, droperidol and dimedrol in burn shock and combined radiation-thermal injury].
abstract: Toxic and pharmacological properties of promedol, droperidol and dimedrol were studied during burn shock and combined radiation and thermal injury (CRTI). Acute toxicity and analgesic effect of promedol were shown to increase in the given period Droperidol analgesic effect enhanced in burn and CRTI, cataleptic action enhanced only in CRTI. A decrease of antihistaminic activity of dimedrol was more pronounced in CRTI.
mesh_terms: D000818:Animals; D002056:Burns / Q000188:drug therapy*; D004155:Diphenhydramine / Q000494:pharmacology* / Q000633:toxicity; D004329:Droperidol / Q000494:pharmacology* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D008297:Male; D008614:Meperidine / Q000031:analogs & derivatives*; D051379:Mice; D011396:Promedol / Q000494:pharmacology* / Q000633:toxicity; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D012774:Shock, Traumatic / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D011396:Promedol; D004155:Diphenhydramine; D008614:Meperidine; D004329:Droperidol
vernacular_title: Izmeneniia farmakodinamicheskikh svoĭstv promedola, droperidola i dimedrola pri ozhogovom shoke i kombinirovannom radiatsionno-termicheskom porazhenii.