Adhesion reduction in the rabbit uterine horn model using an absorbable barrier, TC-7.
Use of a resorbable barrier (TC-7) to reduce adhesion formation was examined in the rabbit uterine horn model. Early evaluation (four days) established that the material remained where initially placed. Examination at two, four and eight weeks postoperatively in both control and treated groups revealed that the extent of adhesion formation did not change as a function of time. When compared to control animals without TC-7, the treated rabbits has a significant reduction (P less than .01) in postoperative adhesion formation. No complications from use of this fabric were noted, and no gross remnants were noted at the two-week time point. TC-7 appears to be an efficacious barrier for reducing adhesion formation in the rabbit uterine horn model.
D000818:Animals; D002482:Cellulose / Q000031:analogs & derivatives*; D002483:Cellulose, Oxidized / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D011183:Postoperative Complications / Q000517:prevention & control; D011817:Rabbits; D013997:Time Factors; D000267:Tissue Adhesions / Q000517:prevention & control; D014591:Uterine Diseases / Q000517:prevention & control*
D002483:Cellulose, Oxidized; D002482:Cellulose