title: Increased incidence of childhood bacterial meningitis. A 25-year study in a defined population in Sweden.
abstract: In a retrospective study in Orebro, Sweden 1956-1980, 201 cases of bacterial meningitis in children over the age of 1 month were analysed. The aetiology was Haemophilus influenzae in 123 cases, Neisseria meningitidis in 55 cases and Streptococcus pneumoniae in 19 cases. We registered a significant increase in incidence of H. influenzae meningitis from 5.6 (1956-1965) to 13.0 (1971-1980) per 100,000 children and year (p less than 0.01). The mortality decreased from 19% to 4% during the period studied. This decrease was primarily due to a reduced mortality in hospital later than 12 h after admission. Hearing impairment was the most frequent sequel (10%) and no change in frequency was observed during the 25 years studied. Hearing impairment was registered significantly more often in cases with a late admission to hospital (greater than 48 h) as compared to cases with an earlier admission (p less than 0.001).
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006311:Hearing Disorders / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008583:Meningitis, Haemophilus / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D008585:Meningitis, Meningococcal / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D008586:Meningitis, Pneumococcal / Q000150:complications / Q000453:epidemiology* / Q000401:mortality; D012189:Retrospective Studies; D013548:Sweden