Infertility in spinal-cord injured male.
Sterility in spinal-cord injured (SCI) men is believed to be caused by ejaculatory dysfunction, genital ductal blockage secondary to infection, and/or impaired spermatogenesis. Semen from SCI men demonstrates diminished numbers of motile, morphologically normal sperm. Testicular biopsies demonstrate impaired spermatogenesis. Leydig and Sertoli cells appear to be normal. Endocrine evaluations reveal normal testosterone levels with an adequate Leydig cell reserve. Luteinizing hormone (LD) and follicle-stimulating hormone (FSH) levels are normal or high with normal or exaggerated stimulation responses. Acute depressions in testosterone, FSH, and LH levels can be seen following SCI, most markedly in quadriplegics. A normal hypothalamic-pituitary-testicular axis is implied by these findings, indicating a primary hypogonadism. Causes of impaired spermatogenesis may include local testicular temperature elevations, nondrainage of the reproductive tract, antisperm antibodies, and recurrent genitourinary infections. Treatment of infertility involves removal of these offending factors, and research is needed to correlate the impaired spermatogenesis with these factors.
D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007248:Infertility, Male / Q000209:etiology*; D008297:Male; D012661:Semen / Q000032:analysis; D013091:Spermatogenesis; D013119:Spinal Cord Injuries / Q000150:complications* / Q000503:physiopathology; D013737:Testis / Q000503:physiopathology; D014552:Urinary Tract Infections / Q000150:complications