Induction of ornithine decarboxylase activity in weanling rat pancreas by an orally administered soy protein isolate.
The induction of ornithine decarboxylase activity in weanling rat pancreas by a trypsin inhibitor-containing soy protein isolate has been studied. Oral administration of the isolate at 0.8, 1.6, 4.0, 6.0, and 8.0 mg/g body wt produced marked elevations in enzyme activity, a response which was proportional to the amount of isolate administered. Ornithine decarboxylase activity was measured at 2, 4, 6, 8, 12, and 24 hr after the isolate was given. A statistically significant increase in enzyme activity was evident as early as 2 hr after treatment; maximal activity occurred at 6 hr and was approximately 140 times greater than the
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D008297:Male; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology; D010190:Pancreatic Neoplasms / Q000139:chemically induced; D014674:Plant Proteins, Dietary / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D030262:Soybean Proteins; D013997:Time Factors; D014886:Weaning
D014674:Plant Proteins, Dietary; D030262:Soybean Proteins; D009955:Ornithine Decarboxylase