A nonneutralizing human IgM monoclonal antibody inhibiting hemagglutination of H3N2 influenza A strains.
A mouse-human hybridoma has been produced by fusing human splenocytes from a Cooley's anemia patient with the murine myeloma P3-NS1/1-Ag 4-1. The hybridoma is stable after 18 months and secretes human IgM. The antibody reacts with some H3N2 influenza A strains and detects an epitope that is part of the hemagglutinin antigen, but does not affect virus infectivity.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D002459:Cell Fusion; D002460:Cell Line; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006384:Hemagglutination; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology*; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D009500:Neutralization Tests; D013789:Thalassemia / Q000276:immunology
D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M