Brain tumors after cranial irradiation for childhood acute lymphoblastic leukemia. A 13-year experience from the Dana-Farber Cancer Institute and the Children's Hospital.
Brain tumors developed in two children after they had received cranial irradiation as central nervous system therapy for acute lymphoblastic leukemia. A review of the literature demonstrated an increased incidence of brain tumors in survivors of acute lymphoblastic leukemia who received central nervous system irradiation. Most of the brain tumors occurred within a decade after radiotherapy. Further data will be required to determine whether early post-radiation brain tumors in patients with acute lymphoblastic leukemia are due to the central nervous system irradiation or to a genetic predisposition.
D000293:Adolescent; D001932:Brain Neoplasms / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006801:Humans; D007945:Leukemia, Lymphoid / Q000532:radiotherapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*