[Inhibition of the formation of platelet thrombus by molsidomine and SIN-1 in the mesenteric vessels rats].
Molsidomine and SIN-1 were tested in a thrombosis model in which thrombi are produced in small mesenteric vessels. An interference contrast system based on a Leitz Orthoplan microscope was used to visualize thrombus formation. Vascular lesions were produced with a Coherent CR-Z supergraphite ion laser (Argon laser) in vessel of 20-30 micron diameter. Molsidomine and SIN-1 i.v. at doses of 0.1 and 0.5 mg/kg had a marked and significant antithrombotic effect in arterioles and in venules. Molsidomine at doses of 0.1 and 0.5 mg/kg had no antithrombotic effect 90 min following intravenous injection.
D000818:Animals; D001160:Arterioles; D008297:Male; D008641:Mesenteric Vascular Occlusion / Q000517:prevention & control*; D008981:Molsidomine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D013927:Thrombosis / Q000517:prevention & control*; D014699:Venules
C002385:linsidomine; D008981:Molsidomine
Inhibition de la formation du thrombus plaquettaire par la molsidomine et le SIN-1 dans les vaisseaux mésentériques du rat.