Electron microscopy and HLA expression of a new cell line of retinoblastoma.
A new continuous retinoblastoma cell line (Rb 355-7) derived from a nonfamilial unilaterally-affected child was studied morphologically and with regard to HLA expression. The tumor was compared with two older and widely studied cell lines, the Y-79 and WERI-Rb1 strains. The Rb 355-7 line grew in tissue culture in clusters and chains. Its doubling time was calculated to be 4.4 days. In contrast to the Y-79 and WERI-Rb1 cell lines, the Rb 355-7 showed a paucity of HLA expression.
D002460:Cell Line; D005134:Eye Neoplasms / Q000276:immunology / Q000648:ultrastructure*; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens / Q000032:analysis*; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D012175:Retinoblastoma / Q000276:immunology / Q000648:ultrastructure*
D006680:HLA Antigens