A new look at the haemopoietic response to cytotoxic agents and stem cell regulation.
A re-evaluation of the response of haemopoietic stem cells, in mice, to radiation and anticancer drugs suggests a precise mechanism for the regulation of the number of stem cells through a control of their rate of differentiation. This analysis which has some counter-intuitive aspects, appears to be the first attempt to obtain a unified explanation for various effects of cytotoxic agents and has some important biological and clinical implications.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000528:radiation effects; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D005246:Feedback; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D014916:Whole-Body Irradiation