title: Effect of cimetidine on prognosis after simple closure of perforated duodenal ulcer.
abstract: A prospective controlled study in 60 patients undergoing simple closure of perforated duodenal ulcer demonstrated a significant (P less than 0.05) benefit following postoperative cimetidine treatment, in terms of avoiding subsequent dyspeptic symptoms and complications of peptic ulcer disease. Thus cimetidine is recommended in the follow-up management of perforated duodenal ulcers.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000517:prevention & control / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D012008:Recurrence
chemical_list: D002927:Cimetidine