Gastrointestinal infections--dietary interactions.
Considerable progress has been made in understanding the complexities involved in the production of bacterial diarrheal diseases. The general mechanisms of disease that have been recognized include enterotoxigenicity, enteroadherence, and invasiveness. The interplay of epithelial cell surface receptors with the surface components of the various bacterial pathogens or their toxins will be reviewed. Knowledge of the stereospecific interactions of bacterial ligands with the eukaryotic receptors has led to the development of new strategies for prevention and therapy. The presence of foodstuffs in the intestinal lumen can contribute by a number of mechanisms to interference with the invading organism's attack on the intestinal cell surfaces. The effects of milk fat and plant lectins on the colonization of the bowel by enteric organisms is discussed.
D000818:Animals; D001424:Bacterial Infections / Q000503:physiopathology*; D002417:Cattle; D002630:Chemotactic Factors / Q000378:metabolism; D002772:Cholera Toxin / Q000378:metabolism; D003967:Diarrhea / Q000382:microbiology / Q000503:physiopathology*; D004032:Diet; D004768:Enterotoxins / Q000378:metabolism; D004926:Escherichia coli; D006162:Guanylate Cyclase; D006801:Humans; D037102:Lectins / Q000378:metabolism; D008892:Milk / Q000378:metabolism; D008970:Molecular Weight; D011956:Receptors, Cell Surface; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled; D011971:Receptors, Immunologic / Q000378:metabolism; D018000:Receptors, Peptide
D002630:Chemotactic Factors; D004768:Enterotoxins; D037102:Lectins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D018000:Receptors, Peptide; C045390:shigella toxin receptor; D002772:Cholera Toxin; D006162:Guanylate Cyclase; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled