B cells in patients with X-linked and 'common variable' hypogammaglobulinaemia.
E- cells from three patients with X-linked and three patients with non-familial 'common variable' hypogammaglobulinaemia were stained by indirect immunofluorescence with a panel of B cell specific monoclonal antibodies (anti-Bp95, Bp35 and Bp135). The number of B cells detected with the pan-B cell antibodies was variable between patients. One patient in each group was found to have near normal numbers of circulating B cells although those of the X-linked patient were clearly immature.
D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000235:genetics*; D000911:Antibodies, Monoclonal / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D008040:Genetic Linkage; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D014960:X Chromosome
D000911:Antibodies, Monoclonal