[Mechanism of action of piracetam on cerebral circulation].
The experimental data show that piracetam exerts a marked effect on cerebral hemodynamics producing a lowering of cerebral artery tonus and an increase of local blood flow. In addition, an increase of GABA content is noted, particularly following an experimentally-induced disorder of cerebral blood circulation. A stable dilatation of the mean capillary diameter, a decrease of the number of non-functioning capillaries in the brain cortex after piracetam administration indicate an important role of piracetam as a cyclic analogue of GABA in regulation and compensation of disordered cerebral hemodynamics.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000503:physiopathology; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D011760:Pyrrolidinones; D005680:gamma-Aminobutyric Acid; D010889:Piracetam
O nekotorykh mekhanizmakh deĭstviia piratsetama na mozgovoe krovoobrashchenie.