title: Intra-arterial streptokinase in the treatment of acute arterial thrombosis.
abstract: Streptokinase and catheter thrombectomy were retrospectively compared in 25 patients who presented with acute ischemia to investigate whether the use of intra-arterial streptokinase offers an advantage in the treatment of acute arterial or graft thrombosis. Streptokinase was used in all patients presenting with acute thrombosis unless the ischemic limb would not tolerate the time required for clot lysis. Complete thrombolysis was achieved in 47 per cent of the occlusions treated with streptokinase and initial limb salvage rate in 37 per cent of the patients. Subsequent surgical procedures were required in seven of eight patients with successful thrombolysis. Catheter thrombectomy reestablished vessel or graft patency in 86 per cent of the procedures and achieved initial limb salvage in 67 per cent of the patients. Long term (greater than six months) patency was achieved in 25 per cent of the patients treated with streptokinase and 44 per cent of the patients with catheter thrombectomy. Streptokinase did not prevent the need for further surgical intervention, improve early patency of these vessels or promote limb salvage when compared with that of catheter thrombectomy.
mesh_terms: D000208:Acute Disease; D001157:Arterial Occlusive Diseases / Q000188:drug therapy* / Q000601:surgery; D002404:Catheterization; D005342:Fibrinolysis / Q000187:drug effects; D006083:Graft Occlusion, Vascular / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007261:Infusions, Intra-Arterial; D007866:Leg / Q000098:blood supply; D008875:Middle Aged; D012189:Retrospective Studies; D013300:Streptokinase / Q000008:administration & dosage*; D013927:Thrombosis / Q000188:drug therapy* / Q000601:surgery
chemical_list: D013300:Streptokinase