title: Lysosomal membrane fragility and catabolism of cytosolic proteins: evidence for a direct relationship.
abstract: A direct relationship was established between the stability of the lysosomal membrane and an estimate of cytosolic protein catabolism, based on loss of radiolabel from prelabeled protein. Lysosomes in the lysosomally-rich digestive cells of the midgut gland of the marine mussel (Mytilus edulis) were destabilized by experimental treatment with phenanthrene.
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D049872:Bivalvia / Q000378:metabolism / Q000648:ultrastructure*; D003600:Cytosol / Q000378:metabolism*; D007425:Intracellular Membranes / Q000187:drug effects / Q000648:ultrastructure; D007700:Kinetics; D008247:Lysosomes / Q000648:ultrastructure*; D010616:Phenanthrenes / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D010616:Phenanthrenes; D011506:Proteins; C031181:phenanthrene