Frontonasal dysplasia associated with tetralogy of Fallot.
Three children with frontonasal dysplasia associated with tetralogy of Fallot are reported. All cases had true hypertelorism and a median nasal groove with absence of the nasal tip. There was no mental deficiency. The facial anomaly is a sporadic, non-genetic interference of the normal development of the face. This is the first report of frontonasal dysplasia associated with a cardiac defect. Multifactorial inheritance of this syndrome is proposed.
D000015:Abnormalities, Multiple / Q000473:pathology*; D001848:Bone Diseases, Developmental / Q000150:complications*; D002648:Child; D005260:Female; D006801:Humans; D006972:Hypertelorism / Q000150:complications*; D007223:Infant; D008297:Male; D009666:Nose / Q000002:abnormalities*; D013771:Tetralogy of Fallot / Q000150:complications*