[The drug combination amoxicillin-clavulanic acid compared to the triple combination ampicillin-gentamicin-metronidazole in the treatment of severe adnexal infections].
Forty-four patients with severe pelvic inflammatory disease were randomly divided into two groups. Single drug therapy with the amoxicillin-clavulanic acid was used in 22 patients (group A). The other 22 patients (group B) were given a combination of ampicillin, gentamicin and metronidazole. Clinical results were comparable in both groups with 91% successes and 9% improvements in group A, against 86% successes, 9% failures, and 5% non-interpretable results in group B. The difference between the two groups was not statistically significant (p = 11.6%). 30% of patients in each group had positive serologic tests for Chlamydiae. This had no influence on therapeutic results but led to secondary prescription of a cycline. Because amoxicillin-clavulanic acid is active against aerobic and anaerobic pathogens, including beta-lactamase-producing microorganisms, it is a satisfactory alternative to the ampicillin-gentamicin-metronidazole combination, especially as it is simpler to use, less toxic and less expensive.
D000658:Amoxicillin / Q000008:administration & dosage*; D000667:Ampicillin / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000188:drug therapy*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage*; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy*; D011897:Random Allocation
D002969:Clavulanic Acids; D004338:Drug Combinations; D005839:Gentamicins; D008795:Metronidazole; D019818:Clavulanic Acid; D000667:Ampicillin; D000658:Amoxicillin
L'association amoxicilline-acide clavulanique comparée à la triple association ampicilline-gentamicine-métronidazole dans le traitement des infections utéro-annexielles sévères.