title: Chlorhexidine for prophylaxis against oral infections and associated complications in patients receiving bone marrow transplants.
abstract: Intensive chemoradiotherapy damages the mucosal barrier of the mouth and throat and is often associated with severe oral inflammation and infection. This study examined the use of a 0.12% chlorhexidine gluconate mouthrinse for prophylaxis against oral complications in patients receiving bone marrow transplants. Use of chlorhexidine mouthrinse produced reductions in oral soft tissue disease and oral microbial burden, including a significant decrease in oral mucositis and Candida infections. The advantage for patients undergoing intensive antineoplastic therapy, and potentially for other immunocompromised patients susceptible to oral infections, was studied.
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002180:Candidiasis, Oral / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D002710:Chlorhexidine / Q000008:administration & dosage / Q000627:therapeutic use*; D003773:Dental Plaque / Q000517:prevention & control; D004311:Double-Blind Method; D005891:Gingivitis / Q000517:prevention & control; D006801:Humans; D007165:Immunosuppression Therapy; D008875:Middle Aged; D009059:Mouth Diseases / Q000517:prevention & control*; D009067:Mouthwashes; D011446:Prospective Studies; D011897:Random Allocation; D013280:Stomatitis / Q000517:prevention & control; D013291:Streptococcus / Q000187:drug effects / Q000302:isolation & purification
chemical_list: D009067:Mouthwashes; D002710:Chlorhexidine