Protective effect of indomethacin against exercise-induced injuries in mouse skeletal muscle fibers.
The role of prostaglandin synthesis was evaluated by indomethacin administration in the pathogenesis of exercise-induced muscle fiber injuries in soleus and quadriceps femoris muscles of mice. The administration of indomethacin before, during, and after 9 h exertion (s.c., 6 mg/kg during and just after exertion and 1.5-3 mg/kg before exertion and later twice a day) caused a significant histologic protection against exercise injuries and considerably reduced the exercise responses of beta-glucuronidase and glucose-6-phosphate dehydrogenase activities (enzymatic indicators of necrotic lesions in skeletal muscles) on the 2nd post-exercise day. The administration of indomethacin before and during the exertion (3 and 10 mg/kg, respectively) but not after exertion caused only a slight histologic protection while the enzymatic indicators showed a nonsignificant effect.
D000818:Animals; D001265:Athletic Injuries / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology*; D007249:Inflammation / Q000517:prevention & control; D008297:Male; D051379:Mice; D009132:Muscles / Q000293:injuries* / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D011453:Prostaglandins / Q000096:biosynthesis*
D011453:Prostaglandins; D005954:Glucosephosphate Dehydrogenase; D005966:Glucuronidase; D007213:Indomethacin