c-Ha-ras gene products are potent inhibitors of cathepsins B and L.
c-Ha-ras proteins produced by Escherichia coli inhibited the activities of cathepsins B and L which had been partially purified from rat kidney. Furthermore, amino acid sequence homology between c-Ha-ras proteins and thiol proteinase inhibitors has been found.
D000595:Amino Acid Sequence; D000818:Animals; D002401:Cathepsin B / Q000037:antagonists & inhibitors* / Q000302:isolation & purification; D056668:Cathepsin L; D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000302:isolation & purification; D003546:Cysteine Endopeptidases; D010450:Endopeptidases; D007668:Kidney / Q000201:enzymology; D007700:Kinetics; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000494:pharmacology*; D016283:Proto-Oncogene Proteins p21(ras); D051381:Rats; D012689:Sequence Homology, Nucleic Acid; D013329:Structure-Activity Relationship
D011518:Proto-Oncogene Proteins; D002403:Cathepsins; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; D056668:Cathepsin L; C534280:Ctsl protein, rat; D016283:Proto-Oncogene Proteins p21(ras)