Mutagenic activity of four furocoumarins: angelicin, 4,5'-dimethyl-angelicin, psoralen and 8-methyl-psoralen on V79 Chinese hamster cells.
Four furocoumarins, two having a linear structure (psoralen and 8-methyl-psoralen) and two having an angular structure (angelicin and 4,5'-dimethyl-angelicin), were studied for their mutagenic activity in the HGPRT system on V79 chinese hamster cells in culture (V79/HGPRT system). All the four drugs, when activated by near-ultraviolet (NUV) light, were effective in inducing HGPRT mutants. Their efficiency ranked in the following order: 8-methyl-psoralen greater than psoralen = 4,5-dimethylangelicin greater than angelicin.
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004351:Drug Resistance; D005363:Ficusin / Q000633:toxicity*; D011564:Furocoumarins / Q000633:toxicity*; D009154:Mutation
D011564:Furocoumarins; C051039:8-methylpsoralen; C021665:4,5'-dimethylangelicin; C011659:angelicin; D005363:Ficusin