title: Mutagenicity of proanthocyanidins.
abstract: Several procyanidins with different degrees of polymerization (dimers, a trimer and a polymer) and extracted from different natural sources were found to be non-mutagenic in the Salmonella mutagenesis assay system. A mutagenic impurity in procyanidin B-4 was isolated by means of reversed-phase high-performance liquid chromatography (HPLC) and identified as rutin with UV spectrometry, co-chromatography on reversed-phase HPLC and gas chromatography-mass spectrometry.
mesh_terms: D000872:Anthocyanins / Q000032:analysis / Q000633:toxicity*; D044946:Biflavonoids; D002392:Catechin; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D009153:Mutagens; D044945:Proanthocyanidins; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
chemical_list: D000872:Anthocyanins; D044946:Biflavonoids; D009153:Mutagens; D044945:Proanthocyanidins; C479578:procyanidin B; C013221:proanthocyanidin; D002392:Catechin