Paradoxical effects of amitriptyline on borderline patients.
A paradoxical increase in suicide threats, paranoid ideation, and demanding and assaultive behavior occurred among 15 borderline inpatients receiving amitriptyline in a double-blind study. This pattern differed significantly from that of 14 nonresponding patients receiving placebo.
D000374:Aggression / Q000187:drug effects; D000639:Amitriptyline / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D001883:Borderline Personality Disorder / Q000188:drug therapy* / Q000523:psychology; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D010259:Paranoid Disorders / Q000209:etiology; D010554:Personality Disorders / Q000188:drug therapy*; D010919:Placebos; D011569:Psychiatric Status Rating Scales; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D013405:Suicide / Q000523:psychology*
D010919:Placebos; D000639:Amitriptyline; D006220:Haloperidol