Toxicity of intravitreally administered alpha-interferon.
We studied the toxicity of single doses of intravitreally administered alpha-interferon in albino rabbits. Doses of 420,000, 210,000, 105,000, 52,500, and 26,250 units/0.1 cc showed no significant histologic changes by light microscopy or altered retinal function assessed by photopic and scotopic electroretinography.
D000818:Animals; D004596:Electroretinography; D007249:Inflammation / Q000139:chemically induced; D007267:Injections; D007370:Interferon Type I / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D012160:Retina / Q000187:drug effects; D014822:Vitreous Body / Q000187:drug effects
D007370:Interferon Type I