The role of the renin-angiotensin system in normotensive and hypertensive rats with varying renin status.
We have investigated the relationship between the acute blood pressure lowering effect of captopril and renin status. Differences in renin status were induced by unilateral artery clipping combined with unilateral or bilateral nephrectomy in rats. The blood pressure lowering effect of captopril correlated very closely with plasma or aortic renin across a very wide range of renin levels.
D000758:Anesthesia; D000803:Angiotensin I / Q000502:physiology; D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology; D006973:Hypertension / Q000097:blood*; D006977:Hypertension, Renal / Q000097:blood; D007672:Kidney Cortex / Q000378:metabolism; D008297:Male; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012077:Renal Artery / Q000502:physiology; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System / Q000187:drug effects; D014520:Urethane
D000804:Angiotensin II; D014520:Urethane; D000803:Angiotensin I; D002216:Captopril; D012083:Renin