title: Acceptance of a connective tissue equivalent for grafting and capsuloligamentary reconstruction.
abstract: A strip of a connective tissue equivalent prepared by using the patient's fibroblasts cultivated in vitro and calf skin collagen, was used for capsuloligamentary reconstruction of the knee. The study of the humoral and cell-mediated immune responses indicated that there was no cell-mediated immune reaction and only a transient humoral reaction 2 months after implantation. This first assay in human surgery gave a good functional result, and an immunological response was no longer observed 5 months after grafting.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D002417:Cattle; D002478:Cells, Cultured; D003094:Collagen / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use*; D003238:Connective Tissue; D005347:Fibroblasts / Q000637:transplantation; D006085:Graft Survival; D006801:Humans; D007717:Knee / Q000601:surgery*; D008023:Ligaments, Articular / Q000601:surgery*; D012867:Skin / Q000166:cytology / Q000378:metabolism; D016038:Skin Transplantation; D013810:Therapeutic Equivalency
chemical_list: D003094:Collagen