The deoxygenations of tosylated adenosine derivatives with Grignard reagents.
The reactions of 2'-O- or 3'-O-tosylated adenosines with Grignard reagents resulted in the formation of various products, which were deoxy or branched-chain deoxy sugar nucleosides, 1',2'-unsaturated nucleosides, 3'-deoxy-2'-keto sugar nucleosides, and so on. The convenient method for the synthesis of the 3'-deoxy-2'-keto adenine nucleoside is described.
D000241:Adenosine / Q000031:analogs & derivatives*; D000473:Alkanes; D055598:Chemical Phenomena; D002621:Chemistry; D006219:Halogens; D008274:Magnesium; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship; D014105:Tosyl Compounds
D000473:Alkanes; D006219:Halogens; D014105:Tosyl Compounds; D008274:Magnesium; D000241:Adenosine