Comparative study of four wound dressings on epithelization of partial-thickness wounds in pigs.
Sixteen shallow wounds were inflicted in each of five Yorkshire white female piglets, 18-20 kg body weight, by a 2-cm diameter, fast-rotating abrasive disc. The injury is similar to a second-degree burn. The wounds were dressed with one of four dressings: Duoderm (Squibb), Op-Site (Smith & Nephew) [corrected], and collagen sponge, covered with either occlusive or semiocclusive polyurethane film (Datascope Corp.). The last two dressings were moistened with saline before application. The rate of epithelization by planimetric quantitation after 3 to 5 days was the same regardless of the dressing used, although the epithelium layer was thicker in wounds treated with Duoderm. Wounds dressed by either of the collagen sponge materials showed a better appearance when visually scored. Wounds dressed with Duoderm or Op-Site were often macerated; Duoderm's paste-like material remained on the wound and was difficult to remove without inflicting discomfort to the patient. Duoderm, and also Op-Site, adhered much more strongly to the intact skin than either type of collagen sponge dressing.
D000818:Animals; D001458:Bandages; D001684:Biological Dressings; D003094:Collagen / Q000627:therapeutic use; D004848:Epithelium / Q000502:physiology; D011140:Polyurethanes / Q000627:therapeutic use*; D012867:Skin / Q000293:injuries*; D012879:Skin Physiological Phenomena; D013552:Swine; D014945:Wound Healing
C027324:Opsiture; D011140:Polyurethanes; D003094:Collagen