14C-desferrioxamine B: uptake into erythrocytes infected with Plasmodium falciparum.
Plasmodium falciparum-infected human erythrocytes (early trophozoite stages) and non-infected erythrocytes were incubated in 1.7 mM 14C-desferrioxamine B (specific activity 1 microCi/2.6 mg desferrioxamine B). After 270 min the cells were washed and the radioactivity was measured in the cell pellet and, after lysis, in cytoplasm and membranes. The results indicate that Desferrioxamine B can the red blood cell and pass through the parasite membrane and that the parasites are killed by the intracellular action of the chelator.
D000818:Animals; D002478:Cells, Cultured; D003676:Deferoxamine / Q000378:metabolism* / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism* / Q000469:parasitology; D006801:Humans; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
D003676:Deferoxamine