title: Peptic ulcer and cancer: an examination of the relationship between chronic peptic ulcer and gastric carcinoma.
abstract: The relationship between peptic ulceration and gastric carcinoma has been examined using data from two large autopsy surveys. The first consisted of over 13,000 autopsies performed in a single hospital over a 20-year period and analysed retrospectively; the second was a prospective series of over 7000 autopsies carried out at 17 centres during a single year. In both, a lower than expected occurrence of coexistent gastric cancer was found in subjects with pathologic evidence of active or past gastric and duodenal ulceration. A statistical association between chronic gastric ulcer and lung cancer was noted. This study has failed to identify an increased risk of gastric carcinoma in patients with chronic gastric ulcer.
mesh_terms: D000368:Aged; D002908:Chronic Disease; D004381:Duodenal Ulcer / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D013276:Stomach Ulcer / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D006113:United Kingdom