title: Inhibition of biosynthesis of Saccharomyces cerevisiae sugar transport system by tunicamycin.
abstract: Tunicamycin apparently inhibited the biosynthesis of glucose, galactose, and maltose transport systems in Saccharomyces cerevisiae. Under the conditions used, the antibiotic also blocked the biosynthesis of invertase, a well-known yeast glycoprotein, as well as the glycosylation of a marker mannoprotein of the yeast cell wall. However, the antibiotic did not affect certain proteins which did not contain carbohydrate. It seems, therefore, that these sugar carriers are glycoproteins.
mesh_terms: D050260:Carbohydrate Metabolism; D002352:Carrier Proteins / Q000096:biosynthesis*; D003864:Depression, Chemical; D005656:Fungal Proteins / Q000096:biosynthesis*; D006023:Glycoproteins / Q000096:biosynthesis; D006026:Glycoside Hydrolases / Q000096:biosynthesis; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism; D014415:Tunicamycin / Q000494:pharmacology*; D043324:beta-Fructofuranosidase
chemical_list: D002352:Carrier Proteins; D005656:Fungal Proteins; D006023:Glycoproteins; D014415:Tunicamycin; D006026:Glycoside Hydrolases; D043324:beta-Fructofuranosidase