Diagnostic problems of leptomeningeal lymphoma. A report of 3 cases.
Three cases are presented in which occult lymphoreticular malignant tumour spread to the spinal and cranial subarachnoid spaces inducing a problematic neurological illness characterised by poorly localised neuralgic pain, slowly progressive paresis and, in 2 patients, papilloedema with computed tomographic evidence of ventricular dilatation. Despite intensive investigations, diagnosis was only achieved at autopsy. A progressive disturbance of spinal and cranial nerve function should direct the attention of the clinician to the possibility of diffuse meningeal involvement by a malignant or inflammatory process.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001099:Arachnoid; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis*; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis*; D009362:Neoplasm Metastasis; D010841:Pia Mater