[Ex vivo study of blood platelet activation in healthy subjects or coronary disease patients after oral intake of molsidomine].
Platelet activation (aggregation, serotonin release, TXB2 synthesis) was studied in 8 normal subjects and 5 patients with unstable angina before and after molsidomine treatment. Serotonin release was the most altered parameter after molsidomine treatment in the group of normal subjects. No significant effect could be detected in patients since platelet reactivity varied in a wide range.
D000284:Administration, Oral; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008981:Molsidomine / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation; D012701:Serotonin / Q000378:metabolism; D013929:Thromboxane B2 / Q000378:metabolism
D012701:Serotonin; D013929:Thromboxane B2; D008981:Molsidomine
Etude ex vivo de l'activation plaquettaire chez le sujet sain ou coronarien, aprés prise orale de molsidomine.