Effect of neurotropin (NSP) on the in vivo and in vitro antibody responses in mice.
Intraperitoneal administration of neurotropin (NSP) did not modify the antibody response to sheep red blood cells (SRBC) in normal BALB/c mice. However, the suppressed antibody responses to SRBC in restraint-stressed mice were favorably restored to normal level by NSP at a dose of 10 or 25 mg/kg either before or even after the stress loading. The suppressed antibody responses in hydrocortisone-treated mice were restored by NSP when it was administered after cortisone. Moreover, NSP augmented the in vitro antibody response to a T cell-dependent antigen, SRBC, but not to T cell-independent antigens such as dinitrophenylated-Ficoll and trinitrophenylated-lipopolysaccharide.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D005260:Female; D006462:Hemolytic Plaque Technique; D006854:Hydrocortisone / Q000494:pharmacology; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D011134:Polysaccharides / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology; D013312:Stress, Physiological / Q000276:immunology
D000276:Adjuvants, Immunologic; D011134:Polysaccharides; C010491:neurotropin; D006854:Hydrocortisone