Ventilatory effects of inhaled capsaicin in man.
Nebulised capsaicin (10(-7) M) was inhaled by 8 normal subjects to study its effects on the pattern of breathing. When compared to the diluent alone capsaicin increased mean inspiratory flow, a reflection of central inspiratory drive (mean increase: 25 +/- 6%, SEM, p less than 0.01), with a trend to increasing ventilation through more rapid but not more shallow breathing. If capsaicin selectively stimulates non-myelinated fibres in the lung in man as it does in dogs, these results suggest that such stimulation in man can alter the pattern of breathing.
D000328:Adult; D000336:Aerosols; D001980:Bronchi / Q000187:drug effects; D002211:Capsaicin / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D012119:Respiration / Q000187:drug effects*; D012129:Respiratory Function Tests
D000336:Aerosols; D002211:Capsaicin