[Laminin: biosynthesis, structure and functions].
Biosynthesized by epithelial, endodermal and Swann type cells, laminin (Lam) is a cross shaped multifunctional glycoprotein formed by the multimeric assembly of subunits which result from the activation of several genes. In vivo, depending on its location, because of its adhesive properties and multivalent affinities, Lam is in association as a part of supramolecular complexes together with compounds of the plasma, the basement membrane and the cell coat. In the basement membrane (MB) Lam has structural and functional roles. It may also be adsorbed on the cell coat or secreted. It is interacting with epithelial cells by the way of a plasma membrane receptor and has a role to play in cellular differentiation and proliferation. Lam is a molecular link of epithelial cells to MB. These features implicate the molecule in organogenesis, embryogenesis and post-traumatic healing. As a structural component of MB and as an attachment factor, Lam is involved: 1 in tumoral invasion which allows metastatic spreading, 2 in homing because metastatic cell display an increased receptivity to the molecule. The study of Lam expression, Lam receptivity and their factors of control should lead to a better understanding of the biochemical and molecular basis of differentiation, embryogenesis, organogenesis and metastasis.
D001485:Basement Membrane / Q000502:physiology; D002465:Cell Movement; D055598:Chemical Phenomena; D002621:Chemistry; D005353:Fibronectins / Q000502:physiology; D006801:Humans; D007797:Laminin / Q000096:biosynthesis / Q000502:physiology*; D009362:Neoplasm Metastasis
D005353:Fibronectins; D007797:Laminin
Laminine: biosynthèse, structure et fonctions.