title: Lesions of the renal papilla induced by paracetamol.
abstract: The acute nephrotoxic effects of paracetamol in the uninephrectomized homozygous Gunn rat are different from those of aspirin. Both compounds induce renal papillary necrosis but paracetamol produces accumulation of non-cellular material in the interstitial space, less damage to interstitial cells, more damage to tubular epithelium, and more severe necrosis of proximal convoluted tubules. In both cortex and papilla only a small fraction of the cells at risk are affected. It is concluded that the findings are consistent with a synergistic nephrotoxic effect between the two compounds, but that the lesions are not sufficiently severe for the natural history of analgesic nephropathy to be wholly explicable by such synergism.
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D001241:Aspirin / Q000633:toxicity; D004357:Drug Synergism; D005260:Female; D007672:Kidney Cortex / Q000648:ultrastructure; D007679:Kidney Medulla / Q000648:ultrastructure; D007681:Kidney Papillary Necrosis / Q000139:chemically induced* / Q000473:pathology; D007685:Kidney Tubules, Collecting / Q000648:ultrastructure; D008854:Microscopy, Electron; D051381:Rats; D011911:Rats, Gunn
chemical_list: D000082:Acetaminophen; D001241:Aspirin