title: Urinary trehalase activity and renal brush-border damage in inhabitants of a cadmium-polluted area (Jinzu River basin).
abstract: Elevated urinary trehalase activity was observed in the inhabitants of the Jinzu River basin. Urinary trehalase activity was correlated with other urinalysis components, such as beta 2-microglobulin, glucose, amino nitrogen, and cadmium, of which a high level was observed in cadmium-polluted areas as compared with the reference area. Renal trehalase is specifically localized in tubular brush borders [M. Nakano, J. Histochem. Cytochem., 30 (1982) 1243-1248]. From these results it is inferred that tubular brush-border damage occurs in inhabitants of the Jinzu River basin.
mesh_terms: D000368:Aged; D002105:Cadmium Poisoning / Q000652:urine*; D004187:Disaccharides / Q000652:urine*; D004785:Environmental Pollutants / Q000506:poisoning*; D006029:Glycosuria / Q000139:chemically induced; D006801:Humans; D007564:Japan; D007684:Kidney Tubules / Q000187:drug effects* / Q000648:ultrastructure; D008871:Microvilli / Q000187:drug effects; D008875:Middle Aged; D014199:Trehalose / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D004187:Disaccharides; D004785:Environmental Pollutants; D001613:beta 2-Microglobulin; D014199:Trehalose