Dependence of food intake on acute and chronic ventricular administration of insulin.
Several lines of evidences indicate that insulin affords short- and long-term neuroendocrine signals to modulate ingestive behavior. To further study a possible role of insulin in the control of food intake, male Wistar rats were subjected to various intra-third cerebro-ventricular applications of saline and insulin. Infusion of 2.0 mIU/rat of insulin at 1100 and 1900 decreased food intake in a 23.5 hr test period. Infusion of 0.5 mIU/rat of insulin between 1100 and 1200 decreased nighttime food intake during the 1st and 2nd days. Infusion of 2.0 mIU/rat/24 hr of insulin from osmotic minipumps decreased nighttime food intake throughout the active pump period and the effect persisted into the post-pump period. The results support the notion that insulin is involved in the regulation of food intake in the rat.
D000367:Age Factors; D000818:Animals; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D007276:Injections, Intraventricular; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D007328:Insulin