title: Drug interactions and incompatibilities.
abstract: The clinical significance of drug interactions in animals is often minor, but, in some cases, they may result in a fatal outcome. In the critically ill patient, the temptation to employ relatively large doses, particularly of antimicrobials or corticosteroids, or to use multiple-drug therapy is enhanced. These two factors, combined with a debilitated state of the patient, increase the probability of severe drug interactions that could mean the difference between recovery or death. It would be prudent to consider the possibility of drug interactions when selecting drugs for concomitant use, evaluating adverse reactions, evaluating laboratory test results, or mixing drugs in vitro.
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D004344:Drug Incompatibility; D004347:Drug Interactions; D004359:Drug Therapy, Combination / Q000662:veterinary*; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses
chemical_list: D000890:Anti-Infective Agents