Analysis of the immunoadjuvant octadecyl tyrosine hydrochloride.
A simple, rapid, high performance liquid chromatographic (HPLC) method for the analysis of the immunoadjuvant octadecyl tyrosine hydrochloride is described. The HPLC procedure can be applied to the direct determination of amino acid reactants present as contaminants in the adjuvant (tyrosine, ethyl tyrosine) and from this information the content of octadecanol reactant can be estimated. Further, these same determinations provide a means of monitoring immunoadjuvant stability in any vaccine preparation.
D000276:Adjuvants, Immunologic / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D011786:Quality Control; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000032:analysis / Q000276:immunology; D014612:Vaccines / Q000032:analysis*
D000276:Adjuvants, Immunologic; D014612:Vaccines; D014443:Tyrosine; C045245:stearyl tyrosine; C051772:ethyl tyrosine ester