Localized cutaneous cryptococcosis successfully treated with ketoconazole.
A 27-year-old female recipient of a renal allograft, treated with systemic steroids and azathioprine, developed progressive cutaneous lesions (an ulcer, a nodule, and an abscess). Histopathologic and tissue-culture examination of the skin lesions led to the diagnosis of cutaneous cryptococcosis. A description of the light and electron microscopic features of the cutaneous lesions is reported. A thorough visceral investigation failed to detect systemic involvement. The patient was treated with oral ketoconazole (400 mg daily) for 6 months. A gradual healing of the lesions was obtained, and cultures performed 3 months after the onset of treatment failed to show Cryptococcus neoformans. No relapse or dissemination has so far been observed.
D000328:Adult; D003453:Cryptococcosis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D003881:Dermatomycoses / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D016030:Kidney Transplantation; D011183:Postoperative Complications; D012867:Skin / Q000473:pathology
D007654:Ketoconazole