Decreased survival of experimental critical flaps in rats after sensory denervation with capsaicin.
The role of capsaicin-sensitive primary sensory neurons on the survival of experimental critical flaps was studied in the rat. Pretreatment with capsaicin, which depletes neuropeptide transmitter content from primary sensory neurons, caused a dramatic decrease in flap survival area compared to normal animals. In contrast, pretreatment with reserpine, which depletes catecholamines from adrenergic neurons, including the sympathetic post-ganglionic fibers, resulted in a significant increase in the survival area. It was concluded that both capsaicin-sensitive primary sensory neurons and sympathetic postganglionic adrenergic neurons play a role in systemic vascular regulation and that intact primary sensory neurons are of importance for the survival of ischemic tissue.
D000818:Animals; D001808:Blood Vessels / Q000294:innervation*; D002211:Capsaicin; D005260:Female; D005727:Ganglia, Spinal / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine; D013524:Surgical Flaps; D013536:Suture Techniques; D014945:Wound Healing
D012110:Reserpine; D002211:Capsaicin