Neuroanatomical evidence of reinnervation in primate allografted (transplanted) skin during cyclosporine immunosuppression.
Histological evidence is presented documenting the reinnervation of sensory mechanoreceptors across major histocompatibility barriers in allografted primate (baboon) skin. Meissner and pacinian corpuscles, as well as hair follicles, showed a spectrum of reinnervation by host axons. Our light and electron microscopic evidence to date has suggested that allografted Merkel cells did not survive transplantation. This, and other instances of tissue and receptor destruction resulting from histoincompatibility, indicated marked differences when skin allografts were compared to autografts with respect to the ability of host axons to locate and reinnervate sensory mechanoreceptors.
D000818:Animals; D008465:Mechanoreceptors / Q000502:physiology*; D009416:Nerve Regeneration; D010141:Pacinian Corpuscles / Q000502:physiology; D010215:Papio; D012867:Skin / Q000294:innervation; D016038:Skin Transplantation