Relative deconvolution. An explicit method for bioavailability comparison not requiring intravenous administration.
A method is presented which enables an explicit evaluation of the relative rate and extent of drug absorption of drug products using an oral drug solution as a reference, thereby avoiding the need for intravenous administration of the drug. The method is demonstrated using data from two sustained release phenylpropanolamine preparations and an oral solution of this drug in a human subject.
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D003692:Delayed-Action Preparations; D006801:Humans; D007700:Kinetics; D008297:Male; D010665:Phenylpropanolamine / Q000008:administration & dosage / Q000378:metabolism*
D003692:Delayed-Action Preparations; D010665:Phenylpropanolamine