title: Human corticoliberin hypothalamic neuroglandular system: comparative immunocytochemical study with anti-rat and anti-ovine corticotropin-releasing factor sera in the early stages of development.
abstract: Development of the paraventriculo-infundibular corticoliberin system was studied by immunocytochemical analysis of human hypothalamic sections using antisera raised against rat or ovine corticotropin-releasing factor (CRF). This comparative study confirms the presence of a significant number of CRF-immunoreactive fibers in the median eminence during the 16th week of fetal development and suggests they may appear as early as the 14th week. Some hypothalamic peri- and paraventricular neurons, observed from the 12th week, are rat-CRF-immunoreactive but not ovine CRF-immunoreactive. There appears to be chronological differences concerning the ability of the two antisera to recognize hypothalamic structures during the early stage of development.
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D003346:Corticotropin-Releasing Hormone / Q000276:immunology / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007031:Hypothalamus / Q000196:embryology / Q000378:metabolism*; D007231:Infant, Newborn; D051381:Rats / Q000276:immunology; D012756:Sheep / Q000276:immunology
chemical_list: D003346:Corticotropin-Releasing Hormone