Antibody probes in the diagnosis of anaplastic tumours. I. Malignant round cell tumours.
The introduction of hybridoma technology has rapidly expanded the scope of immunohistological analysis in the identification of anaplastic malignant tumours. High affinity antibodies now allow the detection of a wide range of tissue-specific antigens so that anaplastic tumours can be accurately classified without the need for costly and often unrewarding, time-consuming ancillary investigations such as electron microscopy, cell culture and chromosomal studies. This review examines the application of a panel of commercially available antibodies of proven specificity, chosen to allow separation of the various entities considered in the differential diagnosis of anaplastic round cell tumours. The specifications of the antibodies are discussed and details of selected cases are provided to illustrate the role of such tissue-specific antibodies as diagnostic probes.
D000708:Anaplasia / Q000175:diagnosis*; D000906:Antibodies / Q000276:immunology*; D002277:Carcinoma / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D004700:Endocrine System Diseases / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007158:Immunologic Techniques; D008223:Lymphoma / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology; D008875:Middle Aged; D009423:Nervous System Neoplasms / Q000175:diagnosis / Q000473:pathology; D009447:Neuroblastoma / Q000175:diagnosis / Q000473:pathology; D012208:Rhabdomyosarcoma / Q000175:diagnosis / Q000473:pathology
D000906:Antibodies