Treatment of clue cell-positive discharge with 200 mg povidone-iodine pessaries. A double-blind and placebo-controlled trial.
In a double-blind randomized study we evaluated the efficacy of povidone-iodine in the treatment of clue cell-positive discharge (CCPD). Vaginal pessaries (200 mg povidone-iodine or placebo) were taken twice daily for five consecutive days. Although the regimen was reasonably well accepted, 'messiness' was reported by 13 of 33 women (39%). Of 44 women enrolled, treatment efficacy was evaluated in 28 women who had both follow-up visits. There was no significant difference in the efficacy of povidone-iodine and placebo pessaries, at either the first or the second follow-up visit (p values 0.46 and 1 respectively). It is concluded that the use of povidone-iodine pessaries, at least in the regimen described, cannot be regarded as an effective therapy for CCPD.
D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006194:Gardnerella vaginalis; D006192:Haemophilus Infections / Q000188:drug therapy*; D006801:Humans; D010570:Pessaries; D010919:Placebos; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000627:therapeutic use*; D014627:Vaginitis / Q000188:drug therapy*
D010919:Placebos; D011206:Povidone-Iodine; D011205:Povidone