Use of the 90Sr applicator for intraoperative radiation therapy in a mouse tumor model.
Intraoperative radiation therapy (IORT) research is limited by the lack of small-animal models. We have implanted B16 melanoma into mouse kidneys, which we subsequently operated upon and irradiated with beta rays from a 90Sr ophthalmic applicator. The IORT has effectively prolonged survival and produced some cures. The strategy should be applicable to other murine tumors and to other internal implantation sites.
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007430:Intraoperative Care / Q000379:methods*; D007680:Kidney Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D008545:Melanoma / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D011879:Radiotherapy Dosage; D013326:Strontium Radioisotopes / Q000008:administration & dosage*
D013326:Strontium Radioisotopes