title: Glioma of the optic nerve with intraocular and intracranial involvement in a dog.
abstract: An anaplastic glioma of the optic nerve, involving the globe, optic chiasma and brain in a 3 1/2-year-old Labrador Retriever is described. The tumour consisted of lobules of small, dark cells intersected by a delicate fibrovascular stroma. There was a high degree of anaplasia and an average of 19 mitoses per x 200 field. The clinical signs were exophthalmos and mydriasis, followed several months later by blindness and, only terminally, by signs of brain involvement.
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000473:pathology / Q000662:veterinary*; D003390:Cranial Nerve Neoplasms / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005910:Glioma / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009901:Optic Nerve Diseases / Q000473:pathology / Q000662:veterinary*