title: Prevention of prolonged voiding problems after unexpected postoperative urinary retention: comparison of phenoxybenzamine and carbachol.
abstract: The efficacy of phenoxybenzamine and carbachol for the prevention of prolonged micturition problems was investigated in 160 consecutive patients with postoperative urinary retention. The patients were randomized into 3 groups: group 1-52 patients given 10 mg. phenoxybenzamine, group 2-55 who received 2 mg. carbachol and group 3-53 given a placebo. The drug was given orally twice daily for 3 days beginning immediately after the first catheterization. Only 17 per cent of the patients in group 1 had recurrent retention after the first catheterization compared to 49 per cent in group 2 and 57 per cent in group 3. Phenoxybenzamine is significantly more effective than carbachol or a placebo for the prevention of prolonged micturition problems in patients with unexpected urinary retention postoperatively.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002217:Carbachol / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010643:Phenoxybenzamine / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D012008:Recurrence; D014546:Urinary Catheterization; D014555:Urination Disorders / Q000209:etiology / Q000517:prevention & control* / Q000628:therapy
chemical_list: D010643:Phenoxybenzamine; D002217:Carbachol