Murine embryonal carcinoma cells express class I MHC-like antigens.
Previous work has concluded that murine embryonal carcinoma (EC) cells, the oncogenic stem cells of teratocarcinomas, do not express class-I, H-2K or D/L gene encoded products. Experiments using cell-mediated lysis, serological and molecular biological approaches show that EC cells do express some major histocompatibility complex (MHC) class I or class I-like molecules.
D000818:Animals; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000235:genetics*; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens / Q000235:genetics*; D006239:Haplotypes; D008297:Male; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D013724:Teratoma / Q000235:genetics / Q000276:immunology*; D013736:Testicular Neoplasms / Q000235:genetics / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D006183:H-2 Antigens