[Cyclosporin A as a diabetogenic cofactor].
Two kidney transplanted patients are reported, who developed an insulin dependent diabetes mellitus after crossing therapeutic Cyclosporine A levels. After stabilisation of the Cyclosporine A levels the insulin dependent diabetes mellitus was completely reversible. The results are indicating Cyclosporine A as the insulin dependent diabetes mellitus initiator.
D000328:Adult; D003524:Cyclosporins / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced*; D005921:Glomerulonephritis / Q000601:surgery*; D006680:HLA Antigens / Q000235:genetics; D015235:HLA-B Antigens; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000601:surgery*; D012306:Risk
D003524:Cyclosporins; D006680:HLA Antigens; D015235:HLA-B Antigens
Cyclosporin A als diabetogener Kofaktor.