Coexistent Wegener's granulomatosis and anti-glomerular basement membrane disease.
Wegener's granulomatosis and Goodpasture's syndrome represent two major causes of a pulmonary-renal syndrome. We describe the clinical course and morphologic features of a patient in whom pulmonary manifestations of Wegener's granulomatosis developed and were followed six months later by anti-glomerular basement membrane disease. Although we regard this as a unique and probably fortuitous association, a genetic predisposition or a secondary form of anti-GBM disease cannot be excluded.
D000368:Aged; D001485:Basement Membrane / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D014890:Granulomatosis with Polyangiitis / Q000150:complications*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D008171:Lung Diseases / Q000150:complications* / Q000473:pathology; D008297:Male