Intestinalization of pancreatic fragments in dogs: improvement in survival rate after acute segmental pancreatitis.
Intestinalization, a new method of pancreatic preservation in which vascularized pancreatic fragments are placed inside a jejunal pouch, has been tested for its effectiveness in the prevention of shock and death due to segmental pancreatitis. Intestinalization of the fragment resulted in the survival of eight of nine animals (89 percent) in which recovery was uneventful, whereas animals with pancreatitis in situ or in a mobilized fragment without intestinalization had a mortality rate of 100 percent within 2 days. We conclude that intestinalization ameliorates the outcome of hemorrhagic pancreatitis in the pancreatic fragment by effectively draining toxic products. The procedure may also be useful in pancreatic transplantation since no reintervention is necessary if graft failure or rejection occurs because the pancreas is accessible by endoscopy.
D000818:Animals; D004285:Dogs; D005260:Female; D006085:Graft Survival; D007583:Jejunum / Q000601:surgery*; D008297:Male; D008954:Models, Biological; D016035:Pancreas Transplantation; D010180:Pancreatectomy; D010195:Pancreatitis / Q000601:surgery*