title: Type 4 renal tubular acidosis (sub-type 2) associated with idiopathic interstitial nephritis.
abstract: An 18-month-old girl presenting with anorexia and failure to thrive, was referred for adenoidectomy. Arterial hypertension was discovered on physical examination. Laboratory results revealed hyperkalaemic, hyperchloraemic, metabolic acidosis, with slight azotemia. Urinary aldosterone excretion and plasma renin were decreased. Renal biopsy showed idiopathic interstitial nephritis. The diagnosis of type 4 renal tubular acidosis, sub-type 2, i.e. primary hyporeninaemic secondary hypoaldosteronism was proposed. According to our knowledge, this disease has not previously been reported in young children, but is well known in azotaemic adults. We therefore propose the inclusion of this uncommon renal disease in the differential diagnosis of failure to thrive in childhood.
mesh_terms: D000141:Acidosis, Renal Tubular / Q000150:complications* / Q000378:metabolism; D000450:Aldosterone / Q000652:urine; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D009395:Nephritis, Interstitial / Q000150:complications* / Q000378:metabolism; D012083:Renin / Q000097:blood
chemical_list: D000450:Aldosterone; D012083:Renin