Endotoxin-induced changes in plasma concentrations of thromboxane and prostacyclin in neonatal calves given antiserum to a mutant Escherichia coli (J-5).
Plasma concentrations of the stable hydrolysis products of thromboxane (Tx) A2, TxB2, and prostacyclin (6-keto-prostaglandin F1 alpha; PGF1 alpha) were evaluated in 22 neonatal calves given endotoxin (0.5 microgram/kg) by slow IV infusion over a 5-hour period. The effect of pretreatment with bovine antiserum to a mutant of Escherichia coli O111:B4 (J-5) on plasma concentrations of these eicosanoids was determined. Plasma concentrations of TxB2 and 6-keto-PGF1 alpha were increased in response to endotoxin infusion. The mean plasma concentrations of TxB2 peaked 1 hour after endotoxin infusion began and was significantly increased from base line through 8 hours. Mean plasma 6-keto-PGF1 alpha concentration increased more slowly and was increased from base line only at 2 hours after endotoxin infusion began. Administration of bovine J-5 antiserum had no significant effect on endotoxin-induced thromboxane and prostacyclin production.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000818:Animals; D000831:Animals, Newborn; D002417:Cattle / Q000097:blood* / Q000276:immunology; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D007116:Immunization, Passive / Q000662:veterinary*; D008297:Male; D013928:Thromboxane A2 / Q000097:blood; D013929:Thromboxane B2 / Q000097:blood; D013931:Thromboxanes / Q000097:blood*
D004731:Endotoxins; D013931:Thromboxanes; D013929:Thromboxane B2; D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha