title: Antibiotic usage in surgery in a large teaching hospital.
abstract: A prevalence study of the antibiotic usage in the surgical departments at the Karolinska Hospital, Stockholm, showed that 126/517 hospitalized patients (24%) received antibiotics and that 100/306 operated patients (33%) received antibiotics. 44 (44%) of the operated patients were given their antibiotics as prophylaxis and 46 (37%) of all patients receiving antibiotics were given them as prophylaxis. Antibiotics were administered intravenously to 35 (28%) patients, orally to 75 (60%), and topically to 16 patients (13%) (eye department only). The most commonly used drugs in prophylaxis were isoxazolylpenicillins and trimethoprim-sulphonamide while cephalosporins accounted for a minor part. In therapy the most commonly used drug was isoxazolylpenicillin, followed by ampicillin derivatives, metronidazole, tetracyclines, trimethoprim-sulphonamide and cephalosporins. The pattern of antibiotic usage differed markedly between departments.
mesh_terms: D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004363:Drug Utilization; D005260:Female; D006748:Hospital Departments; D006757:Hospital Units; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D011292:Premedication; D012737:Sex Factors; D013503:Surgery Department, Hospital; D013514:Surgical Procedures, Operative; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000517:prevention & control; D013548:Sweden
chemical_list: D000900:Anti-Bacterial Agents