title: The ionic requirements for the production of action potential in Achatina fulica Ferussac neuron.
abstract: The ionic requirement for the production of directly elicited action potentials of a tonically auto-active neuron (TAN) in the subesophageal ganglia of the giant African snail, Achatina fulica Ferussac, was studied electrophysiologically. Calcium free Ringer solution containing 1 mM EDTA reversibly abolished the directly elicited action potential. Verapamil (10 micrograms/ml) or cocaine (4 mg/ml) decreased both amplitude and Vmax of the action potentials. The amplitude of the action potential was also slightly decreased in sodium free choline Ringer. However, tetrodotoxin did not significantly affect either the amplitude or Vmax of the directly elicited action potentials. The results suggest that the ionic requirement for generating action potential in snail neuron is not an ordinary sodium spike. Both calcium and sodium ions may participate in carrying charges across the membrane of the action potential.
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000349:Africa; D002118:Calcium / Q000494:pharmacology*; D004594:Electrophysiology; D009474:Neurons / Q000187:drug effects*; D012908:Snails / Q000502:physiology*; D012964:Sodium / Q000494:pharmacology*
chemical_list: D012964:Sodium; D002118:Calcium