[Comparative evaluation of the anti-arrhythmia effectiveness of mezotrin and izoptin].
Isoptin and mesotrin (a new hypothetical calcium antagonist) were administered to 30 patients with frequent and persistent premature beats (22 patients with premature ventricular beats and 8 patients with premature supraventricular beats). The antiarrhythmic activity of mesotrin was nearly twice as high as that of isoptin, the antiarrhythmic effect being achieved in 63 and 33% of patients, respectively, which was especially distinct in ventricular rhythm disturbances (64 and 27%, respectively). The effective dose of mesotrin was approximately 2.5 mg/kg. Isoptin produced the greatest effect on atrio-ventricular conduction, while mesotrin to a great extent influenced atrial and ventricular conduction. Certain side effects of mesotrin were observed, consisting in slight euphoria, ventigo and heavyheadedness subduing spontaneously 10-15 minutes after administering the drug. Care should be taken when administering the drug to patients with sick sinus syndrome because of the possibility of its arrest.
D000293:Adolescent; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000503:physiopathology; D002986:Clinical Trials as Topic; D003959:Diamines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D008991:Monitoring, Physiologic; D014700:Verapamil / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D003959:Diamines; C051404:mesotrin; D014700:Verapamil
Sravnitel'naia otsenka antiaritmicheskoĭ éffektivnosti mezotrina i izoptina.