Haematological abnormalities induced by feeding a common artificial sweetener, saccharin, in ICR Swiss mice.
Haematological studies were carried out to investigate the possible deleterious effects of an extensively used artificial sweetener, saccharin, on albino mice, after feeding it for 1 year at the rate of 0.0 (control), 0.5, 1.0 and 1.5 g/kg body weight/day. Feeding of the chemical at 1.0 and 1.5 g/kg/day revealed a marked decrease in total erythrocyte count (TEC), haemoglobin content (Hb) and packed cell volume (PCV), suggesting the occurrence of anaemia. Differential leucocyte count (DLC) showed a marked increase in the number of polymorphonuclear neutrophils. Saccharin toxicity, in terms of induction of haematological abnormalities in albino mice, is discussed.
D000740:Anemia / Q000139:chemically induced*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004906:Erythrocyte Count; D004909:Erythrocyte Indices; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D051379:Mice; D012439:Saccharin / Q000633:toxicity*
D006454:Hemoglobins; D012439:Saccharin