title: [Local irritation study with isepamicin].
abstract: Local irritative effects of isepamicin (HAPA-B) were studied using muscle and blood vessel of Japanese White rabbits. Muscle irritation experiment was carried out with a single dosage of 100 mg HAPA-B, 100 mg amikacin (AMK), saline, 0.75% acetic acid or 6.0% acetic acid administered into musculus sacrospinalis. Vascular irritation experiment was carried out by allowing HAPA-B to remain in a sealed section of vena retroauricularis for 3 minutes after injection. In result, the muscular irritative activity of HAPA-B was less severe than 0.75% acetic acid but more than saline, and almost equal activity to AMK was observed. The HAPA-B caused very slight inflammation while thrombus was not formed. The vascular irritative activity was very little.
mesh_terms: D000818:Animals; D001284:Atrophy; D001808:Blood Vessels / Q000473:pathology; D004487:Edema / Q000139:chemically induced; D005355:Fibrosis; D005839:Gentamicins / Q000009:adverse effects / Q000494:pharmacology*; D006470:Hemorrhage / Q000139:chemically induced; D007273:Injections, Intramuscular; D008297:Male; D009132:Muscles / Q000473:pathology*; D009336:Necrosis; D011817:Rabbits
chemical_list: D005839:Gentamicins; C016927:isepamicin