[Trial of prevention of coronary aneurysm in Kawasaki's disease using plasma exchange or infusion of immunoglobulins].
Coronary aneurysms are present in 15-25% of cases of Kawasaki disease and are responsible for the morbidity and rapid mortality in this disease. We treated 20 children aged 20 +/- 16 months, less than 15 days (8 +/- 3.2) after onset of the disease, either by plasma exchange (7 exchange transfusions and one plasmapheresis) or by high dose intravenous gammaglobulins. No coronary anomalies or cardiac dysfunction prior to or after therapy (mean follow-up 8.3 +/- 4 months) was found. Tolerance to therapy was good and the course of the disease was arrested by exchange transfusions or shortened by gammaglobulin infusion. We conclude as have the Japanese, that this therapy is efficacious and safe, and should be initiated early.
D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003323:Coronary Aneurysm / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage*; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D010951:Plasma Exchange; D013997:Time Factors
D007136:Immunoglobulins
Essai de prévention des anévrismes coronaires de la maladie de Kawasaki par échanges plasmatiques ou perfusion d'immunoglobulines.