Double-blind comparative trial of standard (commercial) and antibody-affinity-purified tetanus toxoid vaccines.
Tetanus toxoid purified by antibody-affinity chromatography, was compared with conventionally purified material in a double-blind trial in 205 healthy blood donors. There was neither any difference in immunogenicity as assessed by enzyme-linked immunoassay nor in side-reactions between the two vaccines. This study confirms that side-reactions to tetanus toxoid are not eliminated by purifying it.
D000293:Adolescent; D000328:Adult; D002846:Chromatography, Affinity; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013743:Tetanus Antitoxin / Q000032:analysis; D013745:Tetanus Toxoid / Q000009:adverse effects / Q000276:immunology / Q000302:isolation & purification*; D014611:Vaccination
D013743:Tetanus Antitoxin; D013745:Tetanus Toxoid