title: Anticonvulsant activity of the volatile oil from the fruit of Tetrapleura tetraptera.
abstract: The anticonvulsant effect of the volatile oil extracted from the fresh fruits of Tetrapleura tetraptera was investigated in mice. The results obtained show that the fresh oil given intraperitoneally offers some protection against leptazol-induced convulsions. A dose of 0.4 ml of the oil per mouse protected 78% of the animals when administered 30 min prior to leptazol. While 0.6 ml offered no protection from death, the onset of convulsions and the average time of death was prolonged.
mesh_terms: D000354:Africa, Western; D000818:Animals; D000927:Anticonvulsants; D005260:Female; D005638:Fruit; D008297:Male; D051379:Mice; D009822:Oils, Volatile / Q000627:therapeutic use*; D010433:Pentylenetetrazole / Q000494:pharmacology; D010938:Plant Oils / Q000627:therapeutic use*; D010946:Plants, Medicinal; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D000927:Anticonvulsants; D009822:Oils, Volatile; D010938:Plant Oils; D010433:Pentylenetetrazole