Evaluation of the renal clearance of technetium-99m PAHIDA in dogs.
The renal clearance of the technetium-99m complex of para[(biscarboxylmethyl)-aminomethylcarboxyamino]hippuric acid ([99mTc]PAHIDA), has been previously studied in rodents and falls between that of [99mTc]DTPA (diethylenetriaminepentaacetic acid) and iodine-131 (131I) orthoiodohippuran (OIH). To investigate the effect of species variation, the plasma clearance of [99mTc]PAHIDA was investigated in dogs. The plasma disappearance of the renal agent approached that of [99mTc]DTPA and was significantly less than that of OIH. Despite the structural similarities of the PAHIDA ligand and aminohippurate, the [99mTc]PAHIDA complex undergoes little, if any, tubular secretion in the canine kidney.
D000618:Aminohippuric Acids / Q000378:metabolism*; D000818:Animals; D004285:Dogs; D007465:Iodohippuric Acid / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D009942:Organometallic Compounds / Q000378:metabolism; D004369:Pentetic Acid / Q000378:metabolism; D013667:Technetium / Q000378:metabolism; D016284:Technetium Tc 99m Pentetate; D010130:p-Aminohippuric Acid / Q000378:metabolism*
D000618:Aminohippuric Acids; D009942:Organometallic Compounds; D007465:Iodohippuric Acid; D013667:Technetium; D004369:Pentetic Acid; C042972:4-((bis(carboxymethyl)aminomethyl)carbamino)hippuric acid; D016284:Technetium Tc 99m Pentetate; D010130:p-Aminohippuric Acid