Inhibitory effect of human urinary trypsin inhibitor (urinastatin) on lysosomal thiol proteinases.
Effects of human urinary trypsin inhibitor, urinastatin, a compound clinically prescribed for treatment of acute pancreatitis, on lysosomal thiol proteinases were studied. Urinastatin had inhibitory effect on the activities of cathepsins B and H in vitro. In the experimental acute pancreatitis induced by a closed duodenal loop, urinastatin prevented the enhancement of esterolytic activity and the activities of cathepsins B and H. Urinastatin also improved the activities of inhibitors of cathepsins B and H in the case of pancreatitis.
D002401:Cathepsin B / Q000037:antagonists & inhibitors; D056655:Cathepsin H; D002403:Cathepsins / Q000037:antagonists & inhibitors; D003546:Cysteine Endopeptidases; D010450:Endopeptidases; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D008247:Lysosomes / Q000201:enzymology*; D010195:Pancreatitis / Q000201:enzymology; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors / Q000494:pharmacology*
D006023:Glycoproteins; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; D002403:Cathepsins; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; C534126:CTSH protein, human; D056655:Cathepsin H; C028665:urinastatin