Susceptibility to drug-induced hypotension in post-partum psychosis.
Three consecutive cases of post-partum psychosis, admitted to a specialist unit, developed severe postural hypotension during treatment with standard doses of antipsychotic drugs. Post-partum patients may be particularly vulnerable to this side-effect, and the possible role of alpha-adrenoceptors in mediating this increased susceptibility to hypotension is discussed. It is suggested that antipsychotic drugs with relatively selective dopamine-blocking activity may be specifically indicated in the treatment of post-partum psychosis.
D000328:Adult; D002746:Chlorpromazine / Q000009:adverse effects; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000139:chemically induced*; D010868:Pimozide / Q000627:therapeutic use; D011247:Pregnancy; D011618:Psychotic Disorders / Q000150:complications / Q000188:drug therapy*; D011619:Psychotropic Drugs / Q000009:adverse effects* / Q000627:therapeutic use; D011644:Puerperal Disorders / Q000150:complications / Q000188:drug therapy*; D013881:Thioridazine / Q000009:adverse effects; D014268:Trifluoperazine / Q000009:adverse effects
D011619:Psychotropic Drugs; D010868:Pimozide; D014268:Trifluoperazine; D013881:Thioridazine; D002746:Chlorpromazine