Modulation of the progesterone receptor in the fetal uterus of the progesterone-primed guinea pig in vivo and in organ culture.
Guinea pig fetuses were treated with progesterone for 7 days before placing fetal uteri in organ culture to see if progesterone pre-treatment of fetuses in utero would permanently inhibit the spontaneous rise in progesterone receptor which occurs in organ culture. The data show that: the basal level of progesterone receptor in fetal uteri was not affected by the progesterone treatment and progesterone receptor concentrations in vitro were also not inhibited. When guinea pig fetuses were treated sequentially with progesterone and estradiol, estradiol failed to provoke an uterotrophic effect but it retained its ability to stimulate progesterone receptor concentrations.
D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D009924:Organ Culture Techniques; D010637:Phenolsulfonphthalein / Q000494:pharmacology; D011374:Progesterone / Q000494:pharmacology*; D011980:Receptors, Progesterone / Q000187:drug effects / Q000378:metabolism*; D014599:Uterus / Q000196:embryology* / Q000378:metabolism
D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol; D010637:Phenolsulfonphthalein