An investigation of Ki-1 positive large cell lymphoma with antibodies reactive with tissue macrophages.
The diagnosis of true histiocytic lymphoma (THL) represents one of the most difficult and controversial areas of lymph node pathology. Recently, Stein et al. (1985) have demonstrated that a series of tumours presenting with morphological and immunocytochemical features, previously considered as being indicative of THL, share antigenic markers with Reed-Sternberg and mononuclear Hodgkin's cells and, therefore, may be derived from lymphocytes, rather than histiocytes. In this study we have re-investigated some of these cases with a panel of monoclonal antibodies variously reactive with macrophages. Although all cases contain a heavy infiltrate of reactive histiocytes the tumour populations are negative for histiocyte antigens.
D000906:Antibodies; D001706:Biopsy; D006644:Histiocytes / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007158:Immunologic Techniques; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000473:pathology*; D008264:Macrophages / Q000276:immunology*
D000906:Antibodies