title: Effect on experimental palatal candidosis in the Wistar rat of removal and re-insertion of acrylic appliances.
abstract: Palatal candidosis was produced by inoculating Candida albicans 3091 (serotype A) under an acrylic appliance. Two weeks was allowed for infection to occur. Removal of the appliance for a further period of 2 weeks resulted in complete resolution of the lesion histologically but Candida organisms could still be recovered from the mucosal surface. Re-fitting these appliances at the end of this recovery period, without subsequent inoculation, produced a recrudescence of palatal candidosis after a further 2 weeks. One possible explanation is that C. albicans was encouraged to change from the commensal to the pathogenic form in the presence of the palatal appliance.
mesh_terms: D000818:Animals; D002180:Candidiasis, Oral / Q000209:etiology* / Q000473:pathology; D003778:Dentures / Q000009:adverse effects; D009061:Mouth Mucosa / Q000473:pathology; D010159:Palate; D051381:Rats; D011919:Rats, Inbred Strains