title: Colonic bacterial proteases to IgA1 and sIgA in patients with ulcerative colitis.
abstract: The colonic faecal and mucosal associated bacterial populations of five patients with ulcerative colitis and four control patients were studied in detail to assess their ability to produce IgA1-proteases. A total of 330 bacterial strains were isolated from the patients with ulcerative colitis and IgA1-protease activity was unable to be reliably shown in any. It is therefore unlikely that such enzyme production by colonic bacteria plays a significant role in the pathogenesis of ulcerative colitis.
mesh_terms: D001419:Bacteria / Q000201:enzymology*; D003093:Colitis, Ulcerative / Q000382:microbiology*; D003106:Colon / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000382:microbiology; D008297:Male; D010447:Peptide Hydrolases / Q000378:metabolism*; D012697:Serine Endopeptidases
chemical_list: D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D010447:Peptide Hydrolases; D012697:Serine Endopeptidases; C021433:IgA-specific serine endopeptidase