title: Similarities and differences in acute cardiovascular responses to alcohol among normal men of European, Japanese, and Chinese ancestry: a univariate and multivariate analysis.
abstract: Normal young adult males residing in Hawaii (46 of European ancestry, 30 Japanese, 27 Chinese) were tested for changes in heart rate and blood pressure following a dose of 0.59 g of ethanol/kg. The two Oriental groups did not differ in mean changes but, when pooled, differed from Europeans, having increased heart rate and decreased blood pressure. Within-race analyses showed that, contrary to the literature, all three groups have great interindividual differences in cardiovascular responses. In addition, the three races show a basically similar multivariate response: blood pressure more variable than heart rate and blood pressure changes uncorrelated with heart rate changes.
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D044466:Asian People; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D000431:Ethanol / Q000009:adverse effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D044465:White People
chemical_list: D007527:Isoenzymes; D000431:Ethanol; D000444:Aldehyde Dehydrogenase