Early diagnosis and management of renovascular hypertension.
Renovascular hypertension is more common in hypertensive children than in hypertensive adults, and renal artery stenosis is second only to coarctation of the thoracic aorta as a cause of surgically correctable hypertension. Three infants presented with uncontrollable hypertension secondary to renal artery thrombosis due to umbilical artery catheterization for respiratory distress in the neonatal period. They all responded to nephrectomy. A fourth infant had stenosis of a polar vessel secondary to umbilical artery catheterization and was cured by partial nephrectomy. Two infants with renal artery stenosis secondary to fibromuscular dysplasia benefited from revascularization and, at last follow-up, were normotensive and off all blood pressure medication. Ultrasonography, isotope scanning, angiography and selective renal vein renin assays should be used to identify patients with surgically correctable lesions. The use of fine suture material and microvascular surgical techniques, including ex vivo revascularization and autotransplantation, can salvage renal parenchyma and relieve hypertension. Infants with less than 10 percent renal function on the involved side should have a nephrectomy. The infant with an umbilical arterial catheterization line needs blood pressure monitoring and aggressive evaluation and treatment of persistent hypertension.
D005352:Fibromuscular Dysplasia / Q000150:complications; D006801:Humans; D006978:Hypertension, Renovascular / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D007231:Infant, Newborn; D007234:Infant, Premature; D009392:Nephrectomy; D012077:Renal Artery / Q000601:surgery; D012078:Renal Artery Obstruction / Q000150:complications; D013927:Thrombosis / Q000150:complications; D014463:Ultrasonography