Molecular interaction of nonsteroidal compounds with uterine progesterone receptor (Part I).
Progesterone-receptor binding affinity of some nonsteroidal molecules was assessed by competitive protein binding assay in rabbit as well as human uterine cytosol in vitro. Of 40 compounds belonging to 5 different series tested, 3-(p-anisoyl)-2-chloro-6, 7-dimethoxy-quinoline exhibited around 50% inhibition whereas 2-(p-anisoyl) naphthalene and 3-substituted phenyl-1-(3-(2-chloro-6, 7-dialkoxy) quinolinyl)prop-2-en-1-one showed around 20% inhibition in 3H-progesterone binding for rabbit and human uterine progesterone receptor.
D000818:Animals; D001667:Binding, Competitive; D002599:Chalcone / Q000031:analogs & derivatives / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D005260:Female; D006571:Heterocyclic Compounds / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007659:Ketones / Q000378:metabolism; D011817:Rabbits; D011980:Receptors, Progesterone / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism*
D006571:Heterocyclic Compounds; D007659:Ketones; D011980:Receptors, Progesterone; D002599:Chalcone