title: Methyl iodide, a potent inducer of the adaptive response without appreciable mutagenicity in E. coli.
abstract: Methyl iodide (MeI), a very weak mutagen, induced the adaptive response in E. coli to a similar extent to those induced by potently mutagenic methylating agents. MeI potentiated the mutagenicity of a methylating mutagen, N-methyl-N-nitrosourea, by its co-treatment. These results might give indication that MeI directly methylates O6-methylguanine-DNA methyltransferase resulting in induction of the adaptive response and depletion of the repair capacity of enzyme.
mesh_terms: D004260:DNA Repair / Q000187:drug effects*; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D005798:Genes, Bacterial / Q000187:drug effects; D006847:Hydrocarbons, Iodinated / Q000494:pharmacology*; D008745:Methylation; D008770:Methylnitrosourea / Q000494:pharmacology; D008780:Methyltransferases / Q000378:metabolism; D009154:Mutation; D019853:O(6)-Methylguanine-DNA Methyltransferase
chemical_list: D006847:Hydrocarbons, Iodinated; D008770:Methylnitrosourea; C014055:methyl iodide; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase