Immunohistochemical evidence of progestin target cells in the pituitary gland of ovariectomized rat.
Progestin (P) target cells were identified in the pituitary gland of gonadectomized female rats which had been primed with estrogen (E). P staining was localized using the immunohistochemical avidin-biotin-peroxidase (ABP) complex method. Dark brown precipitates were primarily found over the cytoplasm of cells in the pars distalis, but not in the pars intermedia nor in the pars nervosa. The majority of P-sensitive cells in the pars distalis were identical with luteotrophs, a few being lactotrophs. These observations suggest a role of P in the regulation of production and secretion of gonadotrophins in the pituitary glands of female rats.
D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007124:Immunoenzyme Techniques; D007986:Luteinizing Hormone / Q000378:metabolism; D010052:Ovariectomy; D010902:Pituitary Gland / Q000166:cytology / Q000378:metabolism*; D011372:Progestins / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D011980:Receptors, Progesterone / Q000378:metabolism*
D011372:Progestins; D011980:Receptors, Progesterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone