Leukocyte protease activities in myotonic dystrophy: studies on effects of protease inhibitors.
Neutral and acid protease activities inhibited by chymostatin, leupeptin, pepstatin and HgCl2 in mononuclear cells and granulocytes showed no significant differences between myotonic dystrophy patients and controls. These results suggest that chymotrypsin and cathepsin B and D activities are probably normal in leukocytes in myotonic dystrophy.
D016282:Aspartic Acid Endopeptidases; D010450:Endopeptidases / Q000097:blood*; D006098:Granulocytes / Q000201:enzymology; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000201:enzymology*; D007976:Leupeptins / Q000494:pharmacology; D008627:Mercuric Chloride / Q000494:pharmacology; D009000:Monocytes / Q000201:enzymology; D009223:Myotonic Dystrophy / Q000097:blood / Q000201:enzymology*; D015260:Neprilysin; D009842:Oligopeptides / Q000494:pharmacology; D010436:Pepstatins / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology*
D007976:Leupeptins; D009842:Oligopeptides; D010436:Pepstatins; D011480:Protease Inhibitors; C014195:Streptomyces pepsin inhibitor; D008627:Mercuric Chloride; C002101:chymostatin; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; D015260:Neprilysin; C032854:leupeptin; C031375:pepstatin