[Comparison of the verapamil concentration of human blood serum and saliva].
Verapamil concentrations were measured in the samples of blood serum and saliva taken at the same time in patients with angina of effort within 0.5-24 hr after administration of a single dose of the drug (14 persons) or the last dose of the course (10 persons). A mean ratio of saliva verapamil concentration to blood serum concentration was 0.85 +/- 0.09 (from 0.19 to 2.69) after a single administration and 0.77 +/- 0.04 (from 0.29 to 1.09) after the course treatment. A statistically significant (p less than 0.001) positive correlation was revealed between verapamil concentrations in blood serum and saliva after a single administration (r = 0.69) and course treatment (r = 0.80). It is suggested that determination of verapamil concentration in the saliva of patients on long-term verapamil medication should be used for a reference estimation of its level in the blood.
D000787:Angina Pectoris / Q000188:drug therapy / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D005082:Physical Exertion; D011485:Protein Binding / Q000187:drug effects; D012463:Saliva / Q000032:analysis* / Q000378:metabolism; D012471:Salivary Proteins and Peptides / Q000378:metabolism; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism
D012471:Salivary Proteins and Peptides; D014700:Verapamil
Sopostavlenie kontsentratsii verapamila v syvorotke krovi i sliune u cheloveka.