[Ultradian fluctuations in the natural antitumor resistance of mice undergoing transplantation and chemical carcinogenesis].
A study was made of the mouse life span in relation to the time of tumor cell injection on an hourly basis, while the carcinogenic effect was studied in relation to the time of urethan injection. Changes in both the values were shown to vary with ultradian rhythms. It was found that natural killer cell activity against tumor cells, migration index of normal spleen cells in the presence of tumor cells and the activity of carcinogen-metabolising enzyme system of intact animals also exhibited ultradian oscillations. It is assumed that oscillations of natural resistance against transplantable or chemically-induced tumor may be due to the changes of these parameters.
D000204:Activity Cycles; D000818:Animals; D002465:Cell Movement; D002940:Circadian Rhythm; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D005260:Female; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology / Q000276:immunology* / Q000401:mortality; D013154:Spleen / Q000276:immunology; D013997:Time Factors; D014520:Urethane
D014520:Urethane; D003577:Cytochrome P-450 Enzyme System
Ul'tradiannye kolebaniia estestvennoĭ protivoopukholevoĭ rezistentnosti mysheĭ pri transplantatsionnom i khimicheskom kantserogeneze.