Age-related susceptibility to dibromochloropropane.
To compare the acute toxic responses of weanling and adult rats to dibromochloropropane (DBCP), male 4- and 9-week-old rats were given subcutaneously 250 mg/kg DBCP. As compared to 4-week-old rats, 9-week-old rats showed higher mortality, more progressive weight loss and severer tissue injuries in the testis, kidney, intestine and lymphoid organs. These results indicated that weanling rats were less susceptible to DBCP toxicity.
D000375:Aging; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D007422:Intestines / Q000187:drug effects / Q000473:pathology; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008221:Lymphoid Tissue / Q000187:drug effects / Q000473:pathology; D008297:Male; D011407:Propane / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000473:pathology; D014886:Weaning
C007318:1,2-dibromo-3-chloropropane; D011407:Propane