title: Haematological abnormalities induced by feeding a common artificial sweetener, saccharin, in ICR Swiss mice.
abstract: Haematological studies were carried out to investigate the possible deleterious effects of an extensively used artificial sweetener, saccharin, on albino mice, after feeding it for 1 year at the rate of 0.0 (control), 0.5, 1.0 and 1.5 g/kg body weight/day. Feeding of the chemical at 1.0 and 1.5 g/kg/day revealed a marked decrease in total erythrocyte count (TEC), haemoglobin content (Hb) and packed cell volume (PCV), suggesting the occurrence of anaemia. Differential leucocyte count (DLC) showed a marked increase in the number of polymorphonuclear neutrophils. Saccharin toxicity, in terms of induction of haematological abnormalities in albino mice, is discussed.
mesh_terms: D000740:Anemia / Q000139:chemically induced*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004906:Erythrocyte Count; D004909:Erythrocyte Indices; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D051379:Mice; D012439:Saccharin / Q000633:toxicity*
chemical_list: D006454:Hemoglobins; D012439:Saccharin