The comparative activity of pefloxacin, enoxacin, ciprofloxacin and 13 other antimicrobial agents against enteropathogenic microorganisms.
In this study, we compared the activity of pefloxacin, enoxacin and ciprofloxacin against 269 enteropathogenic strains (Campylobacter jejuni, enteropathogenic Escherichia coli, Salmonella typhi, Shigella spp., Vibrio cholerae and Yersinia enterocolitica) with that of rosoxacin, flumequin, nifuroxazide, erythromycin, chloramphenicol, ampicillin, cefotaxime, tetracycline, amikacin, netilmicin, sulfamethoxazole, trimethoprim and co-trimoxazole. Pefloxacin, enoxacin and ciprofloxacin were always among the most active compounds. Furthermore, resistant strains or strains with elevated MIC values were not found. The MIC90 value for these three compounds was less than or equal to 0.25 mg/l, except for C. jejuni where it was 0.3 mg/l and 1.4 mg/l for pefloxacin and enoxacin, respectively.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002168:Campylobacter fetus / Q000187:drug effects; D002939:Ciprofloxacin / Q000494:pharmacology*; D015365:Enoxacin; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000494:pharmacology*; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D015366:Pefloxacin; D012485:Salmonella typhi / Q000187:drug effects; D012760:Shigella / Q000187:drug effects; D014734:Vibrio cholerae / Q000187:drug effects; D015008:Yersinia enterocolitica / Q000187:drug effects
D000900:Anti-Bacterial Agents; D009287:Naphthyridines; D015366:Pefloxacin; D015365:Enoxacin; D002939:Ciprofloxacin; D009643:Norfloxacin