Jogging causes a significant increase in platelet sensitivity to prostacyclin.
Platelet function and platelet sensitivity to PGI2 was studied before and after jogging in seven males and four females in good health. The ADP-induced (1 microM) aggregation, being always increased after physical activity, showed during the entire follow-up period of 12 months a significant decrease at rest and after exercise compared with baseline values. The change in the aggregation response was significant for t alpha at month 1 and for delta tmax at month 2 after starting the jogging. The platelet sensitivity to PGI2, being always diminished after exercise, also increased significantly during the entire follow-up period compared with baseline levels. In contrast to the ADP-induced changes, the changes in platelet sensitivity were significant already at week 2. Our findings indicate that daily physical activity causes a significant improvement in platelet function and reduces platelet activation.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D011464:Epoprostenol / Q000502:physiology*; D005260:Female; D006487:Hemostasis; D006801:Humans; D007590:Jogging; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011446:Prospective Studies; D012420:Running
D000244:Adenosine Diphosphate; D011464:Epoprostenol