The mechanism and structure of thymidylate synthetase.
We have been involved in studies of the mechanism, inhibition and structure of the enzyme thymidylate synthetase. Knowledge of fundamental catalytic features of thymidylate synthetase has accumulated over the past decade, and will be described. Recently, we have been involved in studies of the x-ray crystallography of thymidylate synthetase, the first phase of which has been completed.
D007700:Kinetics; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000378:metabolism*; D014961:X-Ray Diffraction
D013940:Thymidylate Synthase