Abnormally large placenta associated with Beckwith-Wiedemann syndrome.
A 37-year-old G1-P1 was diagnosed by ultrasonography at 26 weeks of gestation as having an abnormally large placenta with hemangiomas and a fetus associated with exomphalos. Placental protein 5 levels were relatively high in placental protein levels in maternal serum. The infant, delivered by cesarean section at 34 weeks, had the typical clinical features associated with Beckwith-Wiedemann syndrome. The abnormally large placenta weighed 1,492 g, measured 25 X 25 X 5.1 cm, and featured multiple hemangiomas. Microscopic placental features included edematous villi, increased fibrin deposition, intervillous thrombi, and multiple angiomatous and cellular chorangiomas.
D000328:Adult; D001506:Beckwith-Wiedemann Syndrome / Q000473:pathology*; D005260:Female; D006391:Hemangioma / Q000097:blood / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000473:pathology*; D008423:Maternal Age; D010920:Placenta / Q000473:pathology*; D010922:Placenta Diseases / Q000473:pathology; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood; D018566:Pregnancy, High-Risk; D014463:Ultrasonography
D011257:Pregnancy Proteins