Solution synthesis of antigenic and inhibiting peptides of the human renin prosegment-2. [Tyr40] preprorenin-(40-50) peptide methyl ester.
The [Tyr40] preprorenin (40-50) peptide methyl ester, an undecapeptide related to the human renin prosegment, has been synthesized using a stepwise strategy with hydrogenolisable protections on the side chains. The final deprotection was very difficult as observed by 1H NMR and reversed phase HPLC. 2D 1H NMR spectroscopy of the purified peptide allowed the assignment of all protons.
D000595:Amino Acid Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004792:Enzyme Precursors / Q000276:immunology; D004952:Esters; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000138:chemical synthesis*; D010446:Peptide Fragments / Q000276:immunology; D012083:Renin / Q000276:immunology; D012996:Solutions; D014443:Tyrosine; D000092502:Renin Inhibitors
D004792:Enzyme Precursors; D004952:Esters; D009842:Oligopeptides; D010446:Peptide Fragments; D012083:Renin; D012996:Solutions; D014443:Tyrosine; D000092502:Renin Inhibitors