[Characteristics of the antihypoxic properties of 3-hydroxypyridine-class antioxidants].
It was found during experiments using three models of hypoxia (hypobaric, normobaric, hemic) in mice that derivatives of 3-hydroxypyridine possess an antihypoxic effect. They are as active as sodium hydroxybutyrate but less active than gutimine. A clear-cut dependence of the antihypoxic activity on the radical character in the 2nd position of 3 hydroxypyridine was revealed. The presence of a hydroxy group in the 3rd position of pyridine ring was shown to be very important for the antihypoxic properties. The data suggesting different degrees of involvement of GABA and benzodiazepine receptors in realization of the antihypoxic effect were obtained.
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006935:Hypercapnia / Q000188:drug therapy / Q000401:mortality; D000860:Hypoxia / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D051379:Mice; D011725:Pyridines / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
D000975:Antioxidants; D011725:Pyridines; C023500:3-hydroxypyridine
Kharakteristika protivogipoksicheskikh svoĭstv antioksidantov iz klassa 3-oksipiridina.