title: [An excess of mental retardation and/or congenital malformations in carriers of reciprocal translocations. A difficult and delicate problem in genetic counseling].
abstract: Excess of mental retardation and/or congenital malformations in reciprocal translocations in man. A difficult problem in genetic counselling: In this report the Leuven experience (1970-1984) on reciprocal translocations is summarized. A total number of 154 unrelated index-patients, carriers of different types of reciprocal translocations, and their families were investigated. The excess of MR/CM in de novo and familial balanced translocation carriers is illustrated and discussed.
mesh_terms: D000013:Congenital Abnormalities / Q000235:genetics*; D005817:Genetic Counseling; D006579:Heterozygote; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D014178:Translocation, Genetic
vernacular_title: Excès de retard mental et/ou malformations congénitales chez les porteurs de translocations réciproques. Un problème difficile et délicat dans le conseil génétique.