[Animal experiment studies of combined suture and glue microanastomoses using a fibrin glue based on the Cohn I human plasma fraction].
A total of 48 end-to-side microvascular anastomoses between the A. and the V. femoralis of Albino Wistar rats were established with and without an additional gluing using the human plasma fraction Cohn I (Cohn-I adhesive) and clinically and histologically examined after 3-4 weeks--group 1 with 4 single button sutures and gluing, group 2 with 8 single button sutures and gluing as well as a control group with the usual suture technique with 12-14 single knob sutures (in each case 16 anastomoses). The time required for anastomosing could not be considerably reduced by the suture-gluing technique. In group 1 the thrombotic occlusion due to vascular wall dehiscences with penetration of the adhesive material into the lumen could not be prevented in eight anastomoses. Owing to the exact vascular wall adaptation with 8 single button (group 2) 14 anastomoses were free just as in the control group. Histologically the tissue-preserving influence of the gluing could be confirmed by the reduction of the number of sutures. Summarising it can be said that the perfectly performed suture technique should continue to play the dominating role, but that the combined suture-gluing technique can be a great help for the surgeon in special cases.
D000818:Animals; D001798:Blood Proteins / Q000627:therapeutic use*; D005263:Femoral Artery / Q000601:surgery; D005268:Femoral Vein / Q000601:surgery; D008297:Male; D008866:Microsurgery / Q000379:methods*; D051381:Rats; D011919:Rats, Inbred Strains; D013536:Suture Techniques; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects
D001798:Blood Proteins; C047487:Cohn fraction I; D014014:Tissue Adhesives
Tierexperimentelle Untersuchungen an kombinierten Naht-Klebe-Mikrogefässanastomosen unter Verwendung eines Fibrinklebers auf der Basis der Humanplasmafraktion Cohn I.