[Monoclonal antibodies to NP protein and their use in studying influenza A viruses].
Monoclonal antibodies to NP-proteins of influenza A/sea gull/Kazakhstan/470/79 (H1N1) virus have been prepared. Each clone interacted with spatially non-overlapping antigenic sites of NP-protein. The clones differed in their capacity to inhibit the polymerase activity of different influenza A virus strains. F-81 clone was shown to interact actively with NP of human influenza A viruses, clone H12 reacted with both human and animal influenza viruses.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis* / Q000302:isolation & purification; D006801:Humans; D007124:Immunoenzyme Techniques; D009980:Influenza A virus / Q000276:immunology*; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D012367:RNA, Viral / Q000037:antagonists & inhibitors; D012261:Ribonucleoproteins / Q000037:antagonists & inhibitors; D014158:Transcription, Genetic; D014758:Viral Core Proteins / Q000037:antagonists & inhibitors / Q000276:immunology*
D000911:Antibodies, Monoclonal; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D012367:RNA, Viral; D012261:Ribonucleoproteins; D014758:Viral Core Proteins
Monoklonal'nye antitela k NP-belku i ikh ispol'zovanie dlia izucheniia virusov grippa A.