[Effect of alcohol on conduction of afferent impulsation from the area of the sinus node of the heart to structures of the central nervous system].
Acute experiments in cats, using the induced potentials technique, showed intraperitoneal 30% alcohol administration (1.5-2 ml per 1 kg body weight) as well as direct application of 2 or 3 ml of similarly concentrated alcohol solution to the sinus node area (SNA) to block afferent impulse conduction from the SNA to central nervous structures, such as cerebral cortex, reticular formation of the midbrain, peri-aqueduct gray matter. The fact that the induced potentials generated within the cerebral cortex and subcortical structures in response to SNA stimulation showed a pattern of change that was similar to the one associated with alcohol administered intraperitoneally or applied directly to SNA has suggested that alcohol may block the cardiac afferent flow directly at the level of SNA structures.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D006321:Heart / Q000294:innervation*; D008636:Mesencephalon / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects; D010487:Periaqueductal Gray / Q000187:drug effects; D012154:Reticular Formation / Q000187:drug effects; D012849:Sinoatrial Node / Q000187:drug effects*
D000431:Ethanol
Vliianie alkogolia na provedenie afferentnoĭ impul'satsii ot zony sinusovogo uzla serdtsa k strukturam tsentral'noĭ nervnoĭ sistemy.