The use of N-acetylcysteine long after an acetaminophen overdose in mice.
N-Acetylcysteine (NAC), given to mice 5 h after an LD50 dose of acetaminophen, decreased 24-h survival to 33%. The reduction in survival observed for late NAC is significantly lower than the survival observed for the LD50 dose alone (53%), and is in sharp contrast to the 100% survival reported for the early use of NAC.
D000082:Acetaminophen / Q000633:toxicity*; D000111:Acetylcysteine / Q000633:toxicity*; D000818:Animals; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D013997:Time Factors
D000082:Acetaminophen; D000111:Acetylcysteine