title: Ketotifen and methacholine-induced bronchospasm.
abstract: In a double-blind investigation the aspecific bronchus threshold was estimated by administration of methacholine to 16 young atopic patients with proven airways hyperreactivity (PC20 histamine less than or equal to 2 mg/ml. The influence of prolonged oral administration (12 weeks) of ketotifen (2 mg/day) on the bronchus threshold value has been studied. No significant elevation was found. It could be concluded that administration of ketotifen, even in prolonged administration, has no anticholinergic effects.
mesh_terms: D000293:Adolescent; D000328:Adult; D001986:Bronchial Spasm / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007665:Ketotifen / Q000627:therapeutic use*; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000494:pharmacology; D010366:Peak Expiratory Flow Rate
chemical_list: D008688:Methacholine Compounds; D016210:Methacholine Chloride; D007665:Ketotifen