Antihypertensive effect of dietary sunflowerseed oil and linseed oil in spontaneously hypertensive rats during a multigeneration feeding study.
Semisynthetic diets enriched with polyunsaturated fatty acids (30 en% sunflowerseed oil or linseed oil) reduced hypertension development in spontaneously hypertensive rats (SHR) compared with control SHR fed on a regular rat chow. The effect was most markedly expressed in the 3rd and 4th generations of a four generation feeding period. PGI2-like production from isolated, pulsatingly perfused aorta preparations was reduced in linseed oil but not in sunflowerseed oil fed rats. Effects on blood pressure and PGI2-like production were abolished when the semisynthetic diets were changed for regular chow (5th and 6th generations).
D000818:Animals; D000959:Antihypertensive Agents; D001012:Aorta, Abdominal / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D011464:Epoprostenol / Q000096:biosynthesis; D005260:Female; D006973:Hypertension / Q000178:diet therapy / Q000378:metabolism / Q000517:prevention & control*; D066298:In Vitro Techniques; D008043:Linseed Oil / Q000494:pharmacology; D008297:Male; D008431:Maternal-Fetal Exchange; D010938:Plant Oils / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D011918:Rats, Inbred SHR; D000074242:Sunflower Oil
D000959:Antihypertensive Agents; D004042:Dietary Fats, Unsaturated; D010938:Plant Oils; D000074242:Sunflower Oil; D008043:Linseed Oil; D011464:Epoprostenol