title: Phylogenetic development of myelin glycosphingolipids.
abstract: Myelin is a highly specialized membrane, which enwraps axons and facilitates saltatory nerve conduction in vertebrates. Galactocerebroside and its sulfate ester, sulfatide, are highly localized in myelin. To understand the role played by these galactosphingolipids we investigated the changes of these myelin-specific compounds during the course of the evolution of myelin. We found that urodele nerve myelin lacks alpha-hydroxy fatty acid-containing galactosphingolipids. Our morphological and physiological studies of urodele nerves indicated that these hydroxy fatty acid-containing galactosphingolipids probably contribute to fast nerve conduction. Also it is suspected that they are involved in the regulation of the thickness of myelin in relation to the size of the axon. In another study, we discovered that glucocerebroside, which has glucose instead of galactose as its carbohydrate component, is abundantly present in the myelin-like sheath membrane of crustacean nerves. Subsequently, the phylogenetic study indicated that galactocerebrosides were limited to the nervous system of deuterostomes, while all protostome nerves contain glucocerebrosides. The role of glucocerebrosides in multilayered membranes and in the conduction velocity of the protostome nervous system is discussed.
mesh_terms: D000663:Amphibians; D000818:Animals; D002554:Cerebrosides / Q000378:metabolism; D006028:Glycosphingolipids / Q000378:metabolism*; D007448:Invertebrates; D009186:Myelin Sheath / Q000378:metabolism*; D009420:Nervous System / Q000378:metabolism; D009431:Neural Conduction; D010802:Phylogeny; D014562:Caudata
chemical_list: D002554:Cerebrosides; D006028:Glycosphingolipids