Cholecystokinin affects water intake as well as neurohypophysial storage of vasopressin and oxytocin in the rat.
Intracerebroventricular injections of CCK were followed by a decrease of vasopressin and oxytocin content in the neurohypophysis. Water intake and body weight were diminished: serum osmolality and haematocrit index increased. These results suggest a possible regulatory role of CCK in water metabolism and release of neurohypophysial hormones.
D000818:Animals; D002766:Cholecystokinin / Q000008:administration & dosage / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D010121:Oxytocin / Q000378:metabolism; D010904:Pituitary Gland, Posterior / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014667:Vasopressins / Q000378:metabolism
D014667:Vasopressins; D010121:Oxytocin; D002766:Cholecystokinin