Amyloid P component is not present in the glomerular basement membrane in Alport-type hereditary nephritis.
Serum amyloid P component (SAP) is a normal plasma glycoprotein immunochemically indistinguishable from amyloid P, a glycoprotein found in all tissue amyloid deposits. SAP has also been shown to be a constituent of normal glomerular basement membrane (GBM). In this study the authors discovered a unique association between SAP and Goodpasture (GP) antigen. In those patients whose GBM lack GP antigen (those with Alport-type hereditary nephritis) SAP is also uniformly absent. Although the relationship between these two components is unknown, this association may provide clues to the abnormality of GBM in Alport-type hereditary nephritis.
D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology; D000941:Antigens / Q000032:analysis; D001485:Basement Membrane / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007668:Kidney / Q000032:analysis; D007678:Kidney Glomerulus / Q000032:analysis*; D008297:Male; D009394:Nephritis, Hereditary / Q000378:metabolism*; D000683:Serum Amyloid P-Component / Q000032:analysis*
D000941:Antigens; D000683:Serum Amyloid P-Component