title: Insulin causes insulin-receptor internalization in human erythrocyte ghosts.
abstract: The effect of incubation with insulin on insulin-receptor internalization by erythrocyte ghosts was investigated. The number of surface insulin receptors decreased by 30-40% after incubation of ghosts with insulin. Total insulin-receptor binding to solubilized ghosts was the same in insulin-incubated and control ghosts, whereas insulin binding to an internal vesicular fraction was substantially increased in insulin-incubated ghosts. Our findings suggest that erythrocyte-ghost insulin receptors are internalized to a vesicular compartment in response to incubation with insulin.
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D011972:Receptor, Insulin / Q000187:drug effects / Q000378:metabolism*
chemical_list: D007328:Insulin; D000255:Adenosine Triphosphate; D011972:Receptor, Insulin