Increased drug sensitivity in Candida albicans cells accumulating 14-methylated sterols.
Multiple increases in drug sensitivity were observed in Candida albicans cells that were accumulating 14-methylated sterols as a result of a mutation or clotrimazole treatment. The possibility was suggested that a change in membrane permeability caused by the alteration in sterol composition was responsible for the increased susceptibility.
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D002463:Cell Membrane Permeability; D003022:Clotrimazole / Q000494:pharmacology; D009154:Mutation; D013261:Sterols / Q000378:metabolism*
D000935:Antifungal Agents; D013261:Sterols; D003022:Clotrimazole