The effect of an oral leukotriene antagonist L-649,923 on histamine and leukotriene D4-induced bronchoconstriction in normal man.
We have studied the effect of prior treatment with an oral leukotriene (LT) antagonist L-649,923, on histamine and LTD4-induced bronchoconstriction in 12 normal male subjects in a double-blind, placebo-controlled, randomized, crossover trial. L-649,923 had no effect on histamine-induced bronchoconstriction but antagonized LTD4-induced bronchoconstriction, causing a mean shift to the right of the dose-response curves of 3.8-fold. This study demonstrates that LT antagonism is possible and safe in man and that LTD4-inhalation challenge testing can be used to detect LT antagonism.
D000328:Adult; D001986:Bronchial Spasm / Q000139:chemically induced*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010654:Phenylbutyrates / Q000494:pharmacology*; D011897:Random Allocation; D012129:Respiratory Function Tests; D013189:SRS-A / Q000494:pharmacology
D010654:Phenylbutyrates; D013189:SRS-A; D006632:Histamine; C050033:L 649923