title: [Substitution of RNA-polymerase sigma-subunits and transcription regulation].
abstract: Recent data on regulation of gene activity in bacteria by substitution of RNA polymerase sigma subunits are reviewed. The htpR gene which controls the switch-on of the Escherichia coli heat-shock protein synthesis codes for sigma 32 subunit. sigma 32-containing RNA polymerase transcribes the heat-shock genes in vitro from specific promoters of no use for RNA polymerase containing the major sigma 70 subunit. Several minor sigma subunits have been found in Bacillus subtilis vegetative cells, in addition to the major sigma 55 subunit, differing in the specificity of promoter recognition. Many B. subtilis genes are controlled by tandemly located promoters recognized by RNA polymerases carrying different sigma subunits. sigma 29 subunit is encoded by spoIIG gene and is probably involved in the regulation of sporulation. Specific sigma subunits for transcribing "middle" or "late" genes are encoded by a number of phages.
mesh_terms: D012321:DNA-Directed RNA Polymerases / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D014158:Transcription, Genetic
chemical_list: D006360:Heat-Shock Proteins; D012321:DNA-Directed RNA Polymerases
vernacular_title: Smena sigma-sub''edinits RNK-polimerazy i reguliatsiia transkriptsii.