title: [Influence of drugs on the effect of antitumor preparations in experiments and in clinic medicine].
abstract: Experimental and clinical data concerning the interaction of cytostatics with diuretics, anticoagulants, neurotropic drugs, prostaglandin inhibitors, etc. are reviewed. It is considered necessary to take into account the possible clinical effect when applying different drugs for treatment of the tumour patients. Side by side with intensification of the antitumour activity of the cytostatic or with a decrease of its toxic effect on haemopoiesis and on the function of parenchymatous organs some undesirable effects such as an increase of the toxicity or a decrease of the antitumour effect are possible. Interaction of cytostatics with different groups of drugs demands further study taking into account the "medicinal background" of the modern population.
mesh_terms: D000493:Allopurinol / Q000627:therapeutic use; D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001463:Barbiturates / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D004347:Drug Interactions; D006801:Humans; D008070:Lipopolysaccharides / Q000627:therapeutic use; D011448:Prostaglandin Antagonists / Q000627:therapeutic use; D011749:Pyrogens / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D000970:Antineoplastic Agents; D001463:Barbiturates; D004232:Diuretics; D008070:Lipopolysaccharides; D011448:Prostaglandin Antagonists; D011749:Pyrogens; C009136:pyrogenal; D000493:Allopurinol
vernacular_title: Vliianie nekotorykh lekarstvennykh sredstv na éffekt protivoopukholevykh preparatov v éksperimente i klinike.