title: Solution synthesis of antigenic and inhibiting peptides of the human renin prosegment-1. [Tyr47, Nle53] preprorenin-(47-60) peptide methyl ester.
abstract: The [Tyr47, Nle53] preprorenin (47-60) peptide methyl ester, a tetradecapeptide related to the human renin prosegment, has been synthesized using a three-segment coupling strategy. Selective deprotection of the segments before coupling allowed an easy removal of the final tetradecapeptide side chain-protecting groups by acidolysis and an easy purification. Antibodies raised against this peptide bound the plasmatic inactive renin.
mesh_terms: D000595:Amino Acid Sequence; D055598:Chemical Phenomena; D002621:Chemistry; D004792:Enzyme Precursors / Q000276:immunology; D006801:Humans; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000276:immunology; D010446:Peptide Fragments / Q000276:immunology; D012083:Renin / Q000276:immunology; D012996:Solutions; D014443:Tyrosine; D000092502:Renin Inhibitors
chemical_list: D004792:Enzyme Precursors; D009842:Oligopeptides; D010446:Peptide Fragments; D012083:Renin; D012996:Solutions; D014443:Tyrosine; D000092502:Renin Inhibitors