[Biopsy findings in kidney transplants after treatment with cyclosporin A].
51 renal transplant biopsies of 37 patients immunosuppressed with Cyclosporin A were histologically reevaluated. Lesions related as well as unrelated to Cyclosporin A treatment were found. Cyclosporin A related findings corresponding to the so-called Cyclosporin A nephropathy were divided into early postoperative (diffuse fibrosis), acute (toxic tubulopathy and others) and chronic changes (arteriolopathy, striped fibrosis with tubular atrophy). Since there is often a combination of Cyclosporin A related and unrelated lesions, it is necessary to define the main lesion in the individual case. Accordingly, the following diagnostic groups were present in the biopsies: Cyclosporin A nephropathy (19 cases), rejection nephropathy (18), rejection and Cyclosporin A nephropathy (9), acute renal failure (3) and other diagnoses (2 cases). For the further management of the patients, the exact diagnosis of Cyclosporin A related and unrelated pathology is important in renal biopsies.
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000473:pathology; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003524:Cyclosporins / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged
D003524:Cyclosporins
Biopsiebefunde an Nierentransplantaten bei Behandlung mit Cyclosporin A.