[Treatment of typhoid fever using ofloxacin. Clinical experience and determination of antibiotic diffusion into the mesenteric lymph nodes].
Nine patients with typhoid fever were given ofloxacin in a daily dosage of 400 mg for ten days. All patients recovered with no relapses. No case of Salmonella typhi carriage was recorded. Diffusion of ofloxacin into mesenteric lymph nodes was studied in four patients. Mean concentration was 1.46 micrograms/g after four 200 mg doses. According to our results, ofloxacin could be considered as one of the alternatives for treating typhoid fever.
D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004058:Diffusion; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism; D008297:Male; D008643:Mesentery; D008875:Middle Aged; D015242:Ofloxacin; D010078:Oxazines / Q000378:metabolism / Q000627:therapeutic use*; D014435:Typhoid Fever / Q000188:drug therapy*
D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin
Traitement des fièvres typhoïdes par ofloxacine. Expérience clinique et détermination de la diffusion ganglionnaire mésentérique de l'antibiotique.