[Diffusion of fosfomycin into the human and rabbit eye (aqueous humor and vitreous body)].
The intraocular distribution of fosfomycin was studied in 32 patients undergoing cataract surgery and in 8 rabbits after experimental infection of one eye by Staphylococcus aureus. Concentrations found 1 to 6 hours after termination of a 4 g fosfomycin infusion ranged from 14 to 18.8 mg/l in the aqueous humor and 8 to 12.5 mg/l in the vitreous body. These levels are higher than the MICs for 80 to 90% of the bacteria responsible for endophthalmitis. In each rabbit, the fosfomycin concentration in the infected eye as compared to the healthy eye was increased 2.5 to 5--fold for the aqueous humor and 4.9 to 19.2--fold for the vitreous body. Fosfomycin, in association with a third generation cephalosporin (ceftriaxone) or one of the new quinolones (pefloxacin) can be recommended for the prevention or early treatment of endophthalmitis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D004058:Diffusion; D009877:Endophthalmitis / Q000188:drug therapy; D005578:Fosfomycin / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000378:metabolism; D013997:Time Factors; D014822:Vitreous Body / Q000378:metabolism*
D005578:Fosfomycin
Etude du passage de la fosfomycine dans l'ceil de l'homme et du lapin (humeur aqueuse et vitré).