[Pharmacokinetics of anti-hypertensive drugs in renal failure].
Anti-hypertensive drugs which are mainly eliminated by the kidney can accumulate in renal failure. Posology of hydrosoluble beta-blockers, converting enzyme inhibitors and central anti-hypertensive drugs should therefore be reduced. Anti-hypertensive drugs whose metabolism is predominantly or exclusively hepatic, such as liposoluble beta-blockers, calcium antagonists and prazosin, can be used at usual posologies. At end-stage renal failure posology of diuretics may have to be increased in order to attain a pharmacodynamic effect.
D000959:Antihypertensive Agents / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D007700:Kinetics
D000959:Antihypertensive Agents
Pharmacocinétique des médicaments anti-hypertenseurs au cours de l'insuffisance rénale.