title: Preoperative use of povidone-iodine. A prospective, randomized study.
abstract: One hundred one adult orthopedic surgical patients were studied in a randomized, prospective clinical trial to compare the effectiveness of the standard povidone-iodine scrub and paint with povidone-iodine painting alone for presurgical skin preparation. No infections occurred in either group. The scrub-plus-paint group showed a 0.601 logarithmic reduction in bacteria counts, compared with 0.622 with painting alone. Further, 36.8% of the patients in the scrub-plus-paint group had skin counts that actually increased after preparation, compared with 13.8% of patients in the paint-only group. The preparation bacterial counts among inpatients, who received preoperative hexachlorophene showers, were significantly lower than that of outpatients, who did not receive preoperative showers. The data support the use of the preoperative hexachlorophene shower and the omission of scrubbing from the surgical skin preparation technique.
mesh_terms: D000553:Ambulatory Care / Q000379:methods; D002986:Clinical Trials as Topic; D006582:Hexachlorophene / Q000008:administration & dosage; D006801:Humans; D009985:Orthopedics / Q000379:methods*; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000008:administration & dosage* / Q000627:therapeutic use; D011300:Preoperative Care; D011897:Random Allocation; D012867:Skin / Q000187:drug effects / Q000382:microbiology*; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D011206:Povidone-Iodine; D011205:Povidone; D006582:Hexachlorophene