Effects of combinations of quinoline-containing antimalarials on Plasmodium falciparum in culture.
Combinations of mefloquine, quinine, amodiaquine, chloroquine and 3-methylchloroquine were tested against chloroquine-resistant and -sensitive strains of Plasmodium falciparum in culture. All these drugs had purely additive interactions in both strains, except for mefloquine. Combinations of mefloquine with any of the other drugs always resulted in subadditive or inhibitory action.
D000655:Amodiaquine / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D004347:Drug Interactions; D015767:Mefloquine; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*
D000962:Antimalarials; D011804:Quinolines; D000655:Amodiaquine; C050873:3-methylchloroquine; D002738:Chloroquine; D011803:Quinine; D015767:Mefloquine