A hypoglycemic factor from the corpus cardiacum of the American cockroach Periplaneta americana.
Thin-layer chromatography of cockroach corpora cardiaca (cc) extracts revealed a fraction (F1 in solvent system 1) which had hyperlipemic activity in locusts and which differed in mobility from synthetic locust adipokinetic hormone I (AKH I). Fractions 4 and 5 exhibited hypolipemic activity when injected into locusts. Pooled samples of these fractions caused a diminution of carbohydrate levels in the cockroach. Bovine insulin mimicked both these effects. No change in hemolymph lipid was evident in the cockroach after injection of either CC fractions 4 and 5 or bovine insulin. Both the active fraction from the cockroach CC and bovine insulin caused a decrease in hemolymph carbohydrate in neck-ligated locusts. Injection of locust hypolipemic hormone, separated from locust CC storage lobes by TLC, into neck-ligated locusts also caused a decrease in hemolymph carbohydrate concentration. Normal locusts showed no change in hemolymph carbohydrate.
D000818:Animals; D002241:Carbohydrates / Q000097:blood*; D003058:Cockroaches / Q000378:metabolism*; D006110:Grasshoppers / Q000378:metabolism; D006458:Hemolymph / Q000187:drug effects / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D008055:Lipids / Q000097:blood; D008297:Male; D009490:Neurosecretory Systems / Q000032:analysis; D010526:Periplaneta / Q000378:metabolism*; D014020:Tissue Extracts / Q000302:isolation & purification / Q000494:pharmacology*
D002241:Carbohydrates; D007328:Insulin; D008055:Lipids; D014020:Tissue Extracts