Are the metabolic characteristics of congenital intraspinal lipoma cells identical to, or different from normal adipocytes?
Congenital intraspinal lipomas are frequently responsible for progressive neurological deficits caused by distortion or compression of the nervous system. Since fat metabolism in these lesions has not been previously studied, the aim of this study was to determine whether intraspinal lipoma cells behave like lipomas or like normal adipocytes. In 11 patients, intraspinal lipoma cells were compared with normal adipocytes isolated from adjacent subcutaneous adipose tissue for the following parameters: lipoprotein lipase (LPL), lipogenesis from U14C glucose, beta-receptor number, adenylate cyclase activity, cyclic AMP production, and lipolysis in response to beta- and alpha 2-adrenergic agonists. No significant difference between these two cell populations was found, suggesting that intraspinal lipomas are not lipomatous tumors, but hamartomatous lesions capable of growth and regression along with the changes in the rest of the fatty pool. This emphasizes the danger of an abnormal weight gain, as well as the possible usefulness of an hypocaloric diet in patients who worsen in spite of previous surgery.
D000273:Adipose Tissue / Q000378:metabolism; D002648:Child; D006801:Humans; D050356:Lipid Metabolism; D008066:Lipolysis; D008067:Lipoma / Q000151:congenital* / Q000378:metabolism; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D016136:Spina Bifida Occulta / Q000150:complications*; D013117:Spinal Cord Compression / Q000209:etiology*; D013125:Spinal Neoplasms / Q000151:congenital* / Q000378:metabolism
D008071:Lipoprotein Lipase