A comparison of regular insulin and vesicle encapsulated insulin on glucose metabolism in diabetic subjects.
In an attempt to preferentially enhance insulin action on the liver, insulin has been encapsulated within lipid vesicles (VEI) bearing a galactosyl unit for which there are high affinity hepatic receptors. To determine whether such a formulation of insulin would have a selective hepatic effect, glucose production and utilization (3(3)H glucose) were measured in IDDM volunteers during infusions of VEI and unencapsulated regular insulin (UI) at rates of 1, 2, 4 and 8 nmol/kg/min (n = 6). Euglycemia was maintained using the glucose clamp technique. Dose-response analysis indicated that VEI insulin was one-third as potent as UI, both on stimulation of glucose utilization and suppression of hepatic glucose production. These results differ from effects of VEI in the dog and do not support the view that in man, insulin incorporation within this preparation of lipid vesicles results in selective hepatic insulinization.
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D008081:Liposomes / Q000008:administration & dosage*; D008099:Liver / Q000378:metabolism; D011897:Random Allocation
D007328:Insulin; D008081:Liposomes; D005947:Glucose