Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells.
Transgenic mice expressing simian virus 40 T antigen under control of the insulin gene regulatory region vary in their response to this protein. Each lineage is characteristically either tolerant to T antigen, or not, in which case autoantibodies arise with high frequency, and lymphocytes infiltrate and disrupt the pancreatic islets. Both non-tolerance and the autoimmune response appear to result from delayed onset of T antigen expression during beta cell development.
D000818:Animals; D000917:Antibody Formation; D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor / Q000276:immunology; D001323:Autoantibodies; D007108:Immune Tolerance; D007515:Islets of Langerhans / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000276:immunology; D009856:Oncogene Proteins, Viral / Q000276:immunology; D010179:Pancreas / Q000473:pathology
D000952:Antigens, Polyomavirus Transforming; D000957:Antigens, Viral, Tumor; D001323:Autoantibodies; D009856:Oncogene Proteins, Viral