title: [Functional status of the rat insular apparatus and adrenal cortex at early periods after irradiation].
abstract: As early as 0.5-3 h after X-irradiation of rats with a lethal dose of 12 Gy glucocorticoid activity of adrenal cortex was enhanced and 11-oxycorticosteroid level in blood was increased. The increasing of the immunoreactive insulin content of blood was registered at the background of hypercorticoidism and normal function of insular apparatus during the first hours following irradiation. At later times (24-72 h), a stable hypercorticoidism developed, the ability of beta-cells to react adequately to glucose was impaired, and IRI content of blood decreased.
mesh_terms: D015062:11-Hydroxycorticosteroids / Q000097:blood; D000302:Adrenal Cortex / Q000503:physiopathology* / Q000528:radiation effects; D000818:Animals; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000503:physiopathology* / Q000528:radiation effects; D008297:Male; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D051381:Rats; D013997:Time Factors
chemical_list: D015062:11-Hydroxycorticosteroids; D007328:Insulin
vernacular_title: Funktsional'noe sostoianie insuliarnogo apparata i kory nadpochechnikov krys v rannie sroki posle oblucheniia.