title: Projections of nucleus paragigantocellularis lateralis to locus coeruleus and other structures in rat.
abstract: The projections of the retrofacial portion of nucleus paragigantocellularis lateralis (retrofacial PGCL) were mapped in the rat with the Phaseolus vulgaris leucoagglutinin anterograde tracing technique. This structure projects to a restricted number of bulbar or spinal nuclei involved in autonomic regulation, principally the intermediolateral cell column of the spinal cord, the nucleus tractus solitarius complex, the lateral parabrachial and Kolliker-Fuse nuclei and the ventrolateral medulla. Retrofacial PGCL also densely innervates the locus coeruleus. This projection originates in large part from phenylethanolamine-N-methyltransferase-immunoreactive cells (C1 adrenergic cluster) as demonstrated by immunohistochemistry combined with the retrograde transport of rhodamine-tagged microbeads. A very small suprabulbar projection of retrofacial PGCL was also detected in some cases.
mesh_terms: D000818:Animals; D004525:Efferent Pathways / Q000033:anatomy & histology; D005455:Fluorescent Antibody Technique; D008125:Locus Coeruleus / Q000033:anatomy & histology*; D008297:Male; D008526:Medulla Oblongata / Q000033:anatomy & histology* / Q000201:enzymology; D010625:Phenylethanolamine N-Methyltransferase / Q000378:metabolism*; D051381:Rats; D013116:Spinal Cord / Q000033:anatomy & histology*; D014666:Vasomotor System / Q000033:anatomy & histology* / Q000201:enzymology
chemical_list: D010625:Phenylethanolamine N-Methyltransferase