Impaired acquired resistance of mice to Klebsiella pneumoniae infection induced by acute NO2 exposure.
The natural resistance of nonimmunized C57Bl/6 mice to an intraperitoneal Klebsiella pneumoniae challenge was not significantly affected by prior continuous exposure to 20 ppm NO2 for 4 days. In contrast, the acquired resistance of mice immunized just before and infected just after NO2 exposure was seriously impaired. This could not be explained by the loss of appetite (about 30%) observed in NO2 treated mice, for neither the natural nor acquired resistance of control air exposed mice given approximately 70% ad libitum food and water were significantly modified.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects; D007114:Immunization; D007710:Klebsiella Infections / Q000276:immunology*; D007711:Klebsiella pneumoniae; D051379:Mice; D008810:Mice, Inbred C57BL; D009585:Nitrogen Dioxide / Q000633:toxicity*
D009585:Nitrogen Dioxide