title: The effect of peripheral administration of peptides on food intake, glucose and insulin in wolf pups.
abstract: In the studies reported here we demonstrate that bombesin decreases food intake in wolf (Canis lupus) pups without altering glucose or insulin levels. A high dose of cholecystokinin-octapeptide (CCK, 5 micrograms/kg) decreased food intake. CCK produced a transient increase in insulin, without altering glucose. Glucagon (0.5 mg/kg) failed to decrease food intake despite producing a marked hyperglycemia and hyperinsulinemia. Calcitonin was ineffective at decreasing food intake, although it did decrease the time spent feeding. These studies suggest a potential role for peripheral peptides in food regulation in the wolf.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001839:Bombesin / Q000494:pharmacology*; D002116:Calcitonin / Q000494:pharmacology*; D002335:Carnivora / Q000502:physiology*; D005247:Feeding Behavior / Q000187:drug effects*; D005934:Glucagon / Q000494:pharmacology*; D007328:Insulin / Q000097:blood*; D007700:Kinetics; D012844:Sincalide / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D002116:Calcitonin; D005934:Glucagon; D012844:Sincalide; D001839:Bombesin