title: Transferrin variants in Japan and New Zealand. Report of an unusually sialyzed TF variant.
abstract: The genetic polymorphism of transferrin (TF) was studied in 2,167 Japanese individuals and in 448 New Zealanders. The three TF C subtypes were identified, but TF C3 was absent from Japanese populations. In addition, three TF B and six TF D variants were observed, each of which occurred either in Japanese or in New Zealanders. Stepwise removal of N-acetyl-neuraminic acid (NANA) with neuraminidase revealed that the most cathodal variant TF DShinnanyo found in a Japanese family was characterized by having only two NANA residues.
mesh_terms: D005787:Gene Frequency; D006801:Humans; D007564:Japan; D009520:New Zealand; D011110:Polymorphism, Genetic; D012794:Sialic Acids / Q000097:blood; D012795:Sialoglycoproteins / Q000235:genetics*; D014168:Transferrin / Q000235:genetics*
chemical_list: D012794:Sialic Acids; D012795:Sialoglycoproteins; D014168:Transferrin