Synthesis of 8-(2"-hydroxyethoxy)adenosine-5',2"-phosphate derivative.
Reaction of 8-bromo-2',3'-O-isopropylidene-5'-O-(tetrahydropyran-2-yl) adenosine (Ib) with lithium 2-(tetrahydropyran-2-yloxy) ethoxide, followed by removal of the tetrahydropyran-2-yl groups, afforded 8-(2''-hydroxyethoxy)-2',3'-O-isopropylideneadenosine (II). Successive treatment of II with n-butyllithium and with methyl dichlorophosphate provided the 5',2''-(methyl phosphate) derivative (IIIa and IIIb).
D000227:Adenine Nucleotides / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009712:Nucleotides, Cyclic / Q000138:chemical synthesis*; D013056:Spectrophotometry, Ultraviolet
D000227:Adenine Nucleotides; D007202:Indicators and Reagents; D009712:Nucleotides, Cyclic; C051670:methyl 8-(2''-hydroxyethoxy)-2',3'-O-isopropylideneadenosine-5',2''-phosphate