title: Enhancement of dissolution rate of hydrochlorothiazide via solid dispersion.
abstract: Solid dispersions of hydrochlorothiazide (1) in mannitol (2) and in dihydroxypropyltheophylline (3) were prepared by melting and solvent methods. For both systems, phase diagrams of simple eutectic type were obtained. A significant increase in dissolution rate was observed for 1/2 and 1/3 physical mixtures and solid dispersion as compared to pure drug. Solubility of 1 in 2 and in 3 solution at 27 degrees C and 37 degrees C was studied. At 37 degrees C the water solubility of the drug increased 3.7 times using 0.4 mol X 1(-1) 3. The solubilization of the drug by 3 in water was due to the formation 1 : 1 soluble complex. 1 tablets from physical mixtures and solid dispersion were prepared. Effect of ageing on the physical properties of the prepared 1 tablets was investigated.
mesh_terms: D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D006852:Hydrochlorothiazide / Q000032:analysis*; D007700:Kinetics; D012995:Solubility; D013607:Tablets
chemical_list: D013607:Tablets; D006852:Hydrochlorothiazide