[Isolation and study of the biological properties of substances stimulating levorin biosynthesis in a mixed actinomycete and yeast culture].
Active components responsible for increased synthesis levels of levorin, a polyenic antibiotic in mixed cultures of an actinomycete and a yeast-like fungus C. tropicalis were isolated from the fermentation broth. Component I identified as succinic acid increased the levels of the antibiotic production by 40-50 per cent. Component II found to be lactic acid increased the antibiotic production levels by 20 per cent. Component III, a mixture of nonidentified substances of the amine nature stimulated biosynthesis of levorin by 20-25 per cent. Addition of a mixture of succinic acid and N-methyl glucosamine to the nutrient medium provided increase of the antibiotic activity of the fermentation broth up to 175-185 per cent as compared to the control.
D000935:Antifungal Agents / Q000096:biosynthesis*; D001234:Aspergillus niger / Q000378:metabolism; D002174:Candicidin / Q000096:biosynthesis*; D002175:Candida / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003470:Culture Media / Q000378:metabolism; D005944:Glucosamine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D007773:Lactates / Q000378:metabolism / Q000494:pharmacology; D019344:Lactic Acid; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D012505:Sarcina / Q000378:metabolism; D013268:Stimulation, Chemical; D013302:Streptomyces / Q000187:drug effects / Q000378:metabolism*; D013386:Succinates / Q000378:metabolism / Q000494:pharmacology; D019802:Succinic Acid
D000935:Antifungal Agents; D003470:Culture Media; D007773:Lactates; D013386:Succinates; D002174:Candicidin; C047635:N-methylglucosamine; D019344:Lactic Acid; D019802:Succinic Acid; D005944:Glucosamine
Vydelenie i izuchenie biologicheskikh veshchestv, stimuliruiushchikh biosintez levorina v sovmestnoĭ kul'ture aktinomitseta i drozhzheĭ.