Blood levels and distribution of talampicillin and bacampicillin in NZW rabbits.
Parameters for blood concentrations of the peroral antibiotics talampicil in and bacampicillin, in NZW rabbits were determined using a two compartment model. On the basis of these pharmacokinetic parameters, a three compartment model was prepared for the concentrations of these drugs in the tongue, gingiva, submandibular gland, parotid gland, cervical lymph-node and mandibular bone. Simulation curves based on the parameters of tissue concentrations revealed visual conformity to the measured values.
D000667:Ampicillin / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D000818:Animals; D007700:Kinetics; D011817:Rabbits; D013626:Talampicillin / Q000097:blood / Q000378:metabolism*; D014018:Tissue Distribution
D013626:Talampicillin; D000667:Ampicillin; C011674:bacampicillin