[Protective effect of forskolin in acetylcholine provocation in healthy probands. Comparison of 2 doses with fenoterol and placebo].
Forskolin, a potent adenylate cyclase activating diterpene-derivative, isolated from the Indian plant Coleus forskohlii, was tested double-blind and cross-over in 12 healthy volunteers (nonsmokers) by whole body plethysmography. All drugs were administered by metered dose inhalers. The bronchodilating effect (after 5 minutes) was as good as following fenoterol. At the beginning (after 3 and 5 minutes) the protective effect against inhaled acetylcholine was as good as following fenoterol while later on (after 15 and 30 minutes) fenoterol resulted in a stronger action.
D000109:Acetylcholine; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D001985:Bronchial Provocation Tests; D002986:Clinical Trials as Topic; D005576:Colforsin / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D005280:Fenoterol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011897:Random Allocation
D005576:Colforsin; D005280:Fenoterol; D000109:Acetylcholine
Protektiver Effekt von Forskolin gegenüber Acetylcholinprovokation bei gesunden Probanden. Vergleich von 2 Dosen mit Fenoterol und Placebo.