Modifying action of vegetable juice on the mutagenicity of beef extract and nitrosated beef extract.
The effect of juices of different vegetables on the mutagenicity of beef extract (with S-9 mix) and nitrosated beef extract (with and without S-9 mix) was examined using the Ames test. All the juices affected the induced mutagenicity of beef extract and nitrosated beef extract in the presence of S-9 mix, but not the mutagenicity of nitrosated beef extract in the absence of S-9 mix. As the vegetable juices appear to affect mutagenicity only in the presence of S-9 mix, it is concluded that the constituents of vegetables do not act directly on the mutagens; the effects are apparently caused by an interaction with the metabolic activation system.
D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D002417:Cattle; D008460:Meat / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000037:antagonists & inhibitors*; D009603:Nitroso Compounds / Q000378:metabolism; D012486:Salmonella typhimurium / Q000235:genetics; D014020:Tissue Extracts / Q000037:antagonists & inhibitors* / Q000633:toxicity; D014675:Vegetables
D009153:Mutagens; D009603:Nitroso Compounds; D014020:Tissue Extracts