title: [Pharmacokinetics of cefmenoxime in the aged subject (60 to 90 years of age) after an intravenous injection of 1 g].
abstract: A pharmacokinetic study of Cefmenoxime (CMX) has been carried out in 17 patients, 60 to 90 years old, following IV injection of 1 gram. Plasma concentrations of CMX were determined in 15 blood samples drawn between 0.25-12th hour by a specific high pressure liquid chromatography. The apparent terminal half lives calculated by regression analysis ranged from 0.94 to 3.8 h. We observed an increase of apparent elimination half life and a decrease of total clearance with aging as compared to that of healthy young subjects. Apparent volume of distribution seemed not to differ from those observed in young adults. There is a correlation between renal function and elimination kinetics of Cefmenoxime. In spite of kinetics modifications, it seems that it is not necessary to modify the dosage regimen in elderly.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015281:Cefmenoxime; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged
chemical_list: D015281:Cefmenoxime; D002439:Cefotaxime
vernacular_title: Pharmacocinétique de la cefménoxime chez le sujet âge (60 à 90 ans) après une injection intraveineuse de 1 g.