Blockade of D-1 receptors by SCH 23390 antagonizes morphine- and amphetamine-induced place preference conditioning.
Morphine (0.5 mg/kg s.c.) and amphetamine (1 mg/kg s.c.) used in a two-compartment place preference test induced strong place preference when paired to the non-preferred environments. They did not modify preference under basal conditions but completely reversed morphine- and amphetamine-induced place preference. Pairing of haloperidol (0.2 mg/kg s.c.) to both environments also abolished the morphine-induced place preference.
D000661:Amphetamine / Q000037:antagonists & inhibitors*; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D018492:Dopamine Antagonists; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*
D001552:Benzazepines; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D009020:Morphine; D000661:Amphetamine; D006220:Haloperidol