title: [Comparative in vitro activity of a new macrolide RU 28965 and of erythromycin against Chlamydia trachomatis].
abstract: Activity of a new macrolide, RU 28965, and erythromycin against 8 Chlamydia trachomatis strains isolated from the human genital tract was studied. Minimal inhibitory concentrations were determined using cycloheximide-treated McCoy cells. Giemsa and immunofluorescence staining with monoclonal antibodies were used to detect Chlamydial inclusions. Immunofluorescence proved more sensitive and easier to read. All the strains were highly susceptible to RU 28965 (MIC = 0.05 mg/l - 0.1 mg/l) and erythromycin (MIC = 0.02 mg/l - 0.2 mg/l).
mesh_terms: D000818:Animals; D002460:Cell Line; D002692:Chlamydia trachomatis / Q000187:drug effects*; D004917:Erythromycin / Q000494:pharmacology*; D007933:Leucomycins / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests / Q000379:methods
chemical_list: D007933:Leucomycins; D004917:Erythromycin
vernacular_title: Activité comparée in vitro d'un nouveau macrolide RU 28965 et de l'érythromycine vis-à-vis de Chlamydia trachomatis.