title: Local necrosis and interstitial nephritis due to topical methyl salicylate and menthol.
abstract: Excessive percutaneous absorption of potentially toxic substances such as menthol and methyl salicylate may occur through local application of heat, such as the use of a heating pad. Menthol and methyl salicylate are found in nonprescription items and used for muscular and arthritic pains. This patient experienced full-thickness skin and muscle necrosis as well as persistent interstitial nephritis as a result of topical application of methyl salicylate and menthol followed by use of a heating pad, despite the manufacturer's warning against the use of heating pads.
mesh_terms: D000279:Administration, Cutaneous; D004338:Drug Combinations; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D008297:Male; D008610:Menthol / Q000009:adverse effects*; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced*; D009336:Necrosis / Q000139:chemically induced*; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D012459:Salicylates / Q000008:administration & dosage / Q000009:adverse effects*; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*
chemical_list: D004338:Drug Combinations; D012459:Salicylates; D008610:Menthol; C033069:methyl salicylate