title: [Genetic activity of carbamate herbicides in Escherichia coli and Saccharomyces cerevisiae].
abstract: DNA-damaging activity and herbicide-induction of gene point mutations, and intragenic mitotic recombination were studied in bacteria and the yeast tester strains. Herbicide (eptam, triallate, tillam, surpass) were not effective in DNA-damaging and mitotic recombination tests. Of the 4 chemicals, only eptam was strongly mutagenic. Dose response curves for eptam differed in bacteria and yeast; maximum mutagenic activity was registered in bacteria at 5 mg/l. Maximum yield of prototrophs was observed after 2 h incubation time. Triallate was moderate, tillam and surpass being weak mutagens for the strains used.
mesh_terms: D002219:Carbamates; D004260:DNA Repair / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D006540:Herbicides / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics
chemical_list: D002219:Carbamates; D006540:Herbicides; D009153:Mutagens
vernacular_title: Geneticheskaia aktivnost' gerbitsidov karbamatnoĭ gruppy u bakteriĭ Escherichia coli i drozhzheĭ Saccharomyces cerevisiae.