Comparison of Duchenne and normal myoblasts from a heterozygote.
To test the hypothesis that the Duchenne muscular dystrophy gene limits the proliferation of myoblasts, we studied myoblasts from a woman who was a carrier of the Duchenne gene and also heterozygous for glucose-6-phosphate dehydrogenase (G6PD), an X-linked enzyme. G6PD-A and G6PD-B cells did not differ in proliferative capacity, implying no difference in proliferative capacity of cells bearing the Duchenne gene or the normal allele.
D002469:Cell Separation; D002478:Cells, Cultured; D002999:Clone Cells / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005434:Flow Cytometry; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D009132:Muscles / Q000473:pathology*; D009136:Muscular Dystrophies / Q000235:genetics / Q000473:pathology*
D005954:Glucosephosphate Dehydrogenase