Side effects of positive pressure ventilation on hepatic function and splanchnic circulation.
Positive pressure ventilation is associated with a reduction and redistribution of cardiac output. Splanchnic blood flow is decreased. Blood supply of the liver is reduced exceeding the fall in cardiac output. As a result oxygen transport to the mesenteric bed and liver is curtailed. There is a concomitant impairment of hepatic venous outflow. These hemodynamic changes may cause functional, structural and metabolic disturbances in organs whose blood supply arises from splanchnic circulation.
D001652:Bile Ducts / Q000503:physiopathology; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation / Q000009:adverse effects*; D007511:Ischemia / Q000209:etiology; D008099:Liver / Q000098:blood supply / Q000378:metabolism; D008102:Liver Circulation; D008107:Liver Diseases / Q000209:etiology / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration / Q000009:adverse effects*; D013152:Splanchnic Circulation; D014655:Vascular Resistance
D010100:Oxygen