The response of humans to surface and secreted antigens of Trichinella spiralis.
Biochemically characterised surface and secreted stage specific antigens were used to analyse the response of humans to infection with Trichinella spiralis. Immuno-coprecipitation and SDS-PAGE of labelled proteins were used to dissect the humoral response of Mexican and European infected sera to each component antigen. The results demonstrate that in man, like laboratory rodents, the response to each protein varies independently. In addition, they permit a more rational approach to the development of improved immuno-diagnostic techniques.
D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D000947:Antigens, Helminth / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D001345:Autoradiography; D004591:Electrophoresis, Polyacrylamide Gel; D004739:England; D006801:Humans; D008800:Mexico; D014234:Trichinella / Q000276:immunology*; D014235:Trichinellosis / Q000276:immunology*
D000947:Antigens, Helminth; D000954:Antigens, Surface