Induction of genetic tandem duplications in Salmonella by polycyclic aromatic hydrocarbon and amine carcinogens.
6 polycyclic aromatic hydrocarbon or similar amine carcinogens were tested as inducers of genetic tandem duplications in a rough strain of Salmonella typhimurium. When metabolically activated by rat-liver microsomes, all 6 were active in inducing genetic tandem duplications, yielding from over 3 times to almost 14 times as many tandem duplicants per viable bacterium as did concurrent uninduced control cultures. These results extend the number and chemical diversity of carcinogens shown to induce genetic duplications in bacterial tester systems. We suggest that polycyclic hydrocarbon carcinogens may act in carcinogenesis by inducing genetic duplications or other genetic rearrangements. Duplication induction may be a useful genetic endpoint for screening potential carcinogens.
D015073:2-Acetylaminofluorene / Q000494:pharmacology; D000640:Amitrole / Q000494:pharmacology; D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000633:toxicity*; D004249:DNA Damage; D004269:DNA, Bacterial / Q000187:drug effects; D004352:Drug Resistance, Microbial; D005796:Genes; D005798:Genes, Bacterial; D008862:Microsomes, Liver / Q000378:metabolism; D005810:Multigene Family / Q000187:drug effects*; D011083:Polycyclic Compounds / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium
D002273:Carcinogens; D004269:DNA, Bacterial; D011083:Polycyclic Compounds; D015073:2-Acetylaminofluorene; D000640:Amitrole