title: Pharmacokinetic factors and their implication in the induction of mouse liver tumors by halogenated hydrocarbons.
abstract: The presently available data on pharmacokinetics of halogenated solvents which produce hepatic tumors in B6C3F1 mice, but not in rats, are reviewed. Such compounds are trichloroethylene, perchloroethylene, 1,1,2-trichloroethane, 1,1,2,2-tetrachloroethane, and dichloromethane. It seems likely that higher metabolic rates in mice (compared with other species) may lead to a species-selective toxicity of such compounds. Recurrent cytotoxicity which leads to stimulation of cell replication seems to be a contributing factor in the pathogenesis of mouse liver tumors. However, it is likely that more than one factor contributes to the unique tumor response of the B6C3F1 mouse.
mesh_terms: D000818:Animals; D004980:Ethane / Q000031:analogs & derivatives / Q000378:metabolism; D006843:Hydrocarbons, Chlorinated / Q000378:metabolism; D006846:Hydrocarbons, Halogenated / Q000378:metabolism* / Q000633:toxicity; D007700:Kinetics; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008752:Methylene Chloride / Q000378:metabolism; D051379:Mice; D013045:Species Specificity; D013750:Tetrachloroethylene / Q000378:metabolism; D014240:Trichloroethanes / Q000378:metabolism; D014241:Trichloroethylene / Q000378:metabolism
chemical_list: D006843:Hydrocarbons, Chlorinated; D006846:Hydrocarbons, Halogenated; D014240:Trichloroethanes; C015530:1,1,2,2-tetrachloroethane; C024567:1,1,2-trichloroethane; D014241:Trichloroethylene; D008752:Methylene Chloride; D004980:Ethane; D013750:Tetrachloroethylene