Effects of chemical combinations on the induction of aneuploidy in Saccharomyces cerevisiae.
Nocodazole, ethyl acetate, acetone and methyl ethyl ketone all are known to induce aneuploidy. Treatment of yeast strain D61.M with mixtures containing ineffective low levels of nocodazole and ineffective low levels of these solvents was highly effective in inducing aneuploidy. Ineffective low levels of nocodazole mixed with ineffective low levels of methyl 2-benzimidazolecarbamate also gave elevated frequencies of aneuploidy. Dimethyl formamide, a solvent that does not induce aneuploidy, mixed with low levels of nocodazole gave no increase in aneuploidy frequency above those levels seen in controls.
D000085:Acetates / Q000494:pharmacology; D000096:Acetone / Q000494:pharmacology; D000782:Aneuploidy; D001562:Benzimidazoles / Q000494:pharmacology; D002074:Butanones / Q000494:pharmacology; D002219:Carbamates; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004126:Dimethylformamide / Q000494:pharmacology; D004357:Drug Synergism; D009153:Mutagens / Q000494:pharmacology*; D015739:Nocodazole; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics
D000085:Acetates; D001562:Benzimidazoles; D002074:Butanones; D002219:Carbamates; D009153:Mutagens; D000096:Acetone; C005222:methylethyl ketone; C007650:ethyl acetate; D004126:Dimethylformamide; C006698:carbendazim; D015739:Nocodazole; D004121:Dimethyl Sulfoxide