Targeting of colloidal particles to the bone marrow.
Since intravenously administered colloidal particles are normally removed efficiently by the reticuloendothelial cells of the liver and spleen only a small fraction of these particles will reach the bone marrow. By coating model microspheres with a block co-polymer (poloxamer 407) it has been possible effectively to hinder the liver/spleen uptake and obtain a deposition of the microspheres primarily in the bone marrow. Such a carrier system will have application in radiodiagnosis and for treatment of various diseases in the bone marrow.
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism*; D003102:Colloids; D006207:Half-Life; D008099:Liver / Q000378:metabolism; D008863:Microspheres; D009928:Organ Specificity; D010316:Particle Size; D011060:Poloxalene; D011092:Polyethylene Glycols; D011137:Polystyrenes; D011817:Rabbits; D013154:Spleen / Q000378:metabolism; D013499:Surface Properties
D003102:Colloids; D011137:Polystyrenes; D011092:Polyethylene Glycols; D011060:Poloxalene