Calcium and vitamin D modulate mouse colon epithelial proliferation and growth characteristics of a human colon tumor cell line.
The role of calcium and vitamin D in the prevention of colorectal cancer is only now being investigated at the organismal, cellular, and molecular biologic levels. Recent epidemiologic studies have supported the hypothesis that dietary calcium and vitamin D may be related to a reduced risk for colon cancer. The evidence from laboratory investigations in animals and in cell culture also indicate a possible preventative effect. Addition of calcium and vitamin D to the roster of developmental cancer chemopreventative agents for further research is warranted.
D000818:Animals; D002118:Calcium / Q000502:physiology* / Q000627:therapeutic use; D002455:Cell Division; D002460:Cell Line; D003106:Colon / Q000473:pathology*; D003110:Colonic Neoplasms / Q000473:pathology* / Q000517:prevention & control; D004848:Epithelium / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D051379:Mice; D014807:Vitamin D / Q000502:physiology* / Q000627:therapeutic use
D014807:Vitamin D; D002118:Calcium