Cyclosporin neurotoxicity in patients treated with allogeneic bone marrow transplantation.
Toxicity to the central nervous system was observed in 3 out of 15 patients receiving cyclosporin prophylaxis for graft-versus-host-disease after allogeneic bone marrow transplantation. Neurological clinical features included grand mal seizures, dysarthria and vestibular and cochlear toxicity. In all three patients, cyclosporin plasma levels were increased at the time of overt clinical neurological signs. The symptoms resolved quickly with the reduction of the cyclosporin dose.
D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D003524:Cyclosporins / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced*
D003524:Cyclosporins; D006680:HLA Antigens