Energy status in HeLa cells after treatment with an arresting anticancer drug.
The energy status of HeLa cells arrested in the G2 phase of the cell cycle by the antineoplastic agent cis-acid was compared with that of normal G2-phase-synchronized cells. The results showed that treatment with the drug has significantly decreased the adenylate pool, adenylate energy charge and phosphorylation potential.
D000227:Adenine Nucleotides / Q000378:metabolism; D004734:Energy Metabolism; D005260:Female; D006367:HeLa Cells / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007399:Interphase; D008130:Lomustine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010710:Phosphates / Q000378:metabolism; D010766:Phosphorylation
D000227:Adenine Nucleotides; D010710:Phosphates; C013792:NSC 153174; D008130:Lomustine