title: Effects of norgestomet on follicular development in postpartum beef cows.
abstract: To examine effects of norgestomet pretreatment on development of follicles and their response to administration of gonadotropin releasing hormone (GnRH), 45 pluriparous suckled beef cows were assigned at random to receive a 6-mg implant of norgestomet for 9 d (inserted 24 d postpartum) or serve as untreated controls. Ovaries were obtained 48 h after removal of implants or 10 to 11 or 20 to 22 h after im administration of 150 micrograms GnRH at 48 h after removal of the implant. The largest follicle (F1) and all follicles within 3 mm in diameter of the F1 were dissected from the ovaries. Theca, granulosa and follicular fluid were separated and assayed for steroids and prostaglandins. Diameters and weights of F1 and weights of follicular components remained unchanged in control cows, but increased by 10 h and declined by 20 h in norgestomet-pretreated cows (treatment X time, quadratic, P less than .05). Ovarian volume and numbers of follicles at the surface of the ovary did not differ with treatment, but the diameter of the second-largest follicle (F2) was smaller (P less than .05) in norgestomet-pretreated cows than in controls (6.0 +/- .9 vs 8.2 +/- .7 mm). The F1 were embedded in the ovary in fewer norgestomet-pretreated than control cows (2/22 vs 8/23; P less than .05). Changes in steroids in F1 paralleled those in size (treatment X time, quadratic, P less than .05). Overall, F1 from norgestomet-pretreated cows had higher (P less than .05) contents of estradiol. Contents of prostaglandins in F1 follicles did not differ with treatment, but increased (P less than .05) following treatment with GnRH. The F2 had lower contents of estradiol than F1. It is suggested that norgestomet effected the maturation of a single follicle which produced more estradiol.
mesh_terms: D000780:Anestrus / Q000502:physiology; D000818:Animals; D002417:Cattle / Q000502:physiology*; D005260:Female; D006080:Ovarian Follicle / Q000187:drug effects* / Q000502:physiology; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology; D049590:Postpartum Period / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D011282:Pregnenediones / Q000494:pharmacology*; D045167:Progesterone Congeners / Q000494:pharmacology*
chemical_list: D010906:Pituitary Hormone-Releasing Hormones; D011282:Pregnenediones; D045167:Progesterone Congeners; C100284:norgestomet