Haemodynamic, radionuclide ventriculography and ergometric evaluation of captopril treatment in congestive heart failure.
Eight patients with NYHA Class II congestive heart failure were studied before and after captopril with right heart catheterization, cycloergometric stress tests and radionuclide 99Tc cineventriculography. Acute administration of captopril increased stroke volume and cardiac index and reduced left ventricular filling pressure. Similar changes though less marked were seen after 30 days of captopril therapy. Functional aerobic capacity and left ventricular performance improved over 15 and 30 days of captopril respectively. We therefore suggest that captopril can be effective also in patients with moderate congestive heart failure.
D000293:Adolescent; D000328:Adult; D002216:Captopril / Q000494:pharmacology / Q000627:therapeutic use*; D006328:Cardiac Catheterization; D005080:Exercise Test; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging
D002216:Captopril