title: Species differences in regenerative hyperplasia of bladder urothelium after transurethral cauterization.
abstract: The early histological changes in bladder urothelium following transurethral cauterization were sequentially studied in female rats, mice, hamsters and guinea pigs. The changes differed markedly between species: papillary hyperplasia or papilloma in the rats and simple hyperplasia in the mice, hamsters and guinea pigs. The regenerative response to the fulgurative ulcer within a given species was similar to the early response previously observed by others following administration of known bladder carcinogens. This suggests that there may be a regulatory mechanism in the urothelium which is common to urothelial proliferations induced by both carcinogenic and non-carcinogenic stimulations, though differing between animal species.
mesh_terms: D000818:Animals; D006224:Cricetinae; D004564:Electrocoagulation / Q000379:methods; D004848:Epithelium / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D006965:Hyperplasia; D008647:Mesocricetus; D051379:Mice; D008809:Mice, Inbred C3H; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013997:Time Factors; D014521:Urethra; D001743:Urinary Bladder / Q000473:pathology* / Q000503:physiopathology