Effect on experimental palatal candidosis in the Wistar rat of removal and re-insertion of acrylic appliances.
Palatal candidosis was produced by inoculating Candida albicans 3091 (serotype A) under an acrylic appliance. Two weeks was allowed for infection to occur. Removal of the appliance for a further period of 2 weeks resulted in complete resolution of the lesion histologically but Candida organisms could still be recovered from the mucosal surface. Re-fitting these appliances at the end of this recovery period, without subsequent inoculation, produced a recrudescence of palatal candidosis after a further 2 weeks. One possible explanation is that C. albicans was encouraged to change from the commensal to the pathogenic form in the presence of the palatal appliance.
D000818:Animals; D002180:Candidiasis, Oral / Q000209:etiology* / Q000473:pathology; D003778:Dentures / Q000009:adverse effects; D009061:Mouth Mucosa / Q000473:pathology; D010159:Palate; D051381:Rats; D011919:Rats, Inbred Strains