Aluminemic disturbance of technetium-99m DTPA renal function measurement.
During follow-up study of a patient with surgically corrected unilateral renal ischemia, using computer image generated [99mTc]diethylenethiaminepentaacetic acid (DTPA) glomerular filtration rate (GFR) and [131I]orthoiodohippurate estimated renal plasma flow (ERPF), we observed prominent gastric and intestinal uptake of 99mTc. Profound alteration in the GFR results, but not the ERPF results, was also observed. Radiopharmaceutical breakdown was suspected and shown to be endogenous and due to hyperaluminemia at 28 ng/ml. These case findings add DTPA to the list of 99mTc radiopharmaceuticals that have previously been reported to have altered biodistribution when hyperaluminemia is present. The case findings also reaffirm the benefits of obtaining images to corroborate the validity of quantitative data and demonstrate that quantitative radionuclide renal function data are not independent of renal chemical handling.
D000535:Aluminum / Q000097:blood*; D005919:Glomerular Filtration Rate; D006801:Humans; D006978:Hypertension, Renovascular / Q000097:blood / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D004369:Pentetic Acid / Q000378:metabolism; D011184:Postoperative Period; D011866:Radioisotope Renography; D012079:Renal Circulation; D013667:Technetium / Q000378:metabolism; D016284:Technetium Tc 99m Pentetate; D014018:Tissue Distribution
D013667:Technetium; D004369:Pentetic Acid; D000535:Aluminum; D016284:Technetium Tc 99m Pentetate