Effect of Candida morphology on amphotericin B susceptibility.
We showed that brief exposures to amphotericin B (AmB) inhibited the induction of new Candida germ tubes and the lengthening of partially induced germ tubes. Blastoconidia with germ tubes were more susceptible to AmB killing, and this varied directly with the induction period and the AmB exposure period. AmB did not preferentially affect germ tube adherence to fibrin matrices.
D000666:Amphotericin B / Q000494:pharmacology*; D000704:Analysis of Variance; D002176:Candida albicans / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development
D000666:Amphotericin B