Prostacyclin synthesis by vascular tissue. Effect of extracellular Ca2+.
Prostacyclin (PGI2) synthesis in vascular tissue is stimulated by free Ca2+. Concentrations in excess of 4 mM result in a sustained release of PGI2, but not other prostanoids, from rat aorta. This effect arises by increased synthesis of PGI2 and not through the inhibition of its metabolism. Physico-chemical examination of serum and plasma extract has indicated that much of the PGI2-stimulating activity reported for human serum derives from the presence of free Ca2+.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001769:Blood; D001808:Blood Vessels / Q000378:metabolism*; D002118:Calcium / Q000494:pharmacology*; D002850:Chromatography, Gel; D011464:Epoprostenol / Q000096:biosynthesis*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats
D011453:Prostaglandins; D011464:Epoprostenol; D002118:Calcium