Antimicrobial properties of 2 aliphatic amines and chlorhexidine in vitro and in saliva.
The surfactants tetradecylamine, hexadecylamine and chlorhexidine have been compared with regard to their ability to inhibit microbial growth. Antibacterial activity was assessed by tube dilution methods. Tetradecylamine and chlorhexidine were similar in antibacterial activity, being effective at low concentrations against most organisms tested. Hexadecylamine also inhibited growth but at higher concentrations. Viable counts of salivary organisms were monitored in volunteers over 48 h after one rinse with the agents. The initial reduction in numbers of total viable salivary bacteria and streptococci by tetradecylamine and of streptococci by hexadecylamine had disappeared 3 h after a single mouth rinse, but the reduction in numbers of all salivary bacteria by chlorhexidine was more prolonged.
D000328:Adult; D000588:Amines / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D002176:Candida albicans / Q000187:drug effects; D002710:Chlorhexidine / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006801:Humans; D006838:Hydrocarbons; D007778:Lactobacillus / Q000187:drug effects; D008297:Male; D012463:Saliva / Q000382:microbiology*; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D013295:Streptococcus mutans / Q000187:drug effects; D013997:Time Factors
D000588:Amines; D006838:Hydrocarbons; C020514:N-tetradecylamine; C013553:hexadecylamine; D002710:Chlorhexidine