Cisapride in non-ulcer dyspepsia. Results of a placebo-controlled trial.
The effect of cisapride, 10 mg three times daily, was evaluated in a double-blind randomized study in 118 patients with non-ulcer dyspepsia. Peptic ulcer disease was excluded by endoscopy, gallstones by ultrasonography, and chronic pancreatitis by a series of non-invasive tests. Symptomatic improvement was evaluated by interview after 2 and 4 weeks; the patients also kept a diary. Cisapride caused significant improvement compared with placebo with regard to frequency and severity of symptoms and may therefore be useful in the therapy of non-ulcer dyspepsia.
D020117:Cisapride; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004415:Dyspepsia / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D010437:Peptic Ulcer / Q000175:diagnosis; D010880:Piperidines / Q000627:therapeutic use*; D011897:Random Allocation
D010880:Piperidines; D020117:Cisapride