[Attempt at preventive treatment of esophagitis caused by intubation during intensive care].
A randomized prospective trial was designed to evaluate the preventive treatment of esophagitis in 31 intensive care patients who had a nasogastric feeding tube for at least 10 days. Fourteen patients (group B) received no preventive treatment while 17 patients (group A) received 300 mg of cimetidine every 6 h intravenously and 11 g of colloidal aluminium phosphate every 4 h per os. All patients were fed a standard diet through their nasogastric tube at a constant rate of 30 Kcal/kg/day. Endoscopic controls at day 1 and 10 showed that the number of initial and final esophagitis was not different in groups B and A: 7 and 8 at day 1, 11 and 10 at day 10, respectively. The inefficiency of this preventive treatment suggested that acid gastroesophageal reflux is not a major factor in the occurrence of nasogastric feeding tube-induced esophagitis. However as esophagitis is associated with a more severe Knaus index and a greater number of gastric stress ulcer risk factors, it is suggested that decreased defense of the mucosa may be a key factor in the occurrence of this type of esophagitis.
D000328:Adult; D000368:Aged; D000535:Aluminum / Q000627:therapeutic use*; D017607:Aluminum Compounds; D000863:Antacids / Q000627:therapeutic use*; D002927:Cimetidine / Q000627:therapeutic use*; D004941:Esophagitis / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007441:Intubation, Gastrointestinal / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation; D012151:Resuscitation
D017607:Aluminum Compounds; D000863:Antacids; D010710:Phosphates; D002927:Cimetidine; D000535:Aluminum; C012714:aluminum phosphate
Tentative de traitement préventif des oesophagites sur sonde en réanimation.