The influence of insulin on 5-methoxytryptamine-induced wet dog shake behavior in rats.
The administration of insulin intraperitoneally (2 U/kg) and intracerebroventricularly (4 U per rat) caused an increased wet dog shake response to 5-methoxytryptamine, suggesting an increase in reactivity of central serotonergic structures. Glucose, in doses which prevented hypoglycemia virtually did not change the effect of insulin.
D008735:5-Methoxytryptamine / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001786:Blood Glucose / Q000378:metabolism; D004357:Drug Synergism; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D014363:Tryptamines / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D014363:Tryptamines; D012701:Serotonin; D008735:5-Methoxytryptamine