[Search for anti-inflammatory preparations among the derivatives of succinic acid heteryl amides].
The antiinflammatory activity and acute toxicity of 44 derivatives of heteryl amides of succinic acid (acids, esters, amides) were studied. This series of compounds was found to be promising for the search of nonsteroidal, practically nontoxic antiphlogistics. The structural-pharmacological analysis was performed and the dependence of the biological effect on the compound structure was revealed.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005557:Formaldehyde; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D051379:Mice; D013329:Structure-Activity Relationship; D013386:Succinates / Q000627:therapeutic use*; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013386:Succinates; D005557:Formaldehyde
Poisk protivovospalitel'nykh preparatov v riadu proizvodnykh geterilamidov iantarnoĭ kisloty.