Control of tubulin gene expression during metacyclogenesis of Trypanosoma cruzi.
During differentiation of the dividing epimastigote to the non-dividing metacyclic trypomastigote form of the parasitic protozoan Trypanosoma cruzi there is a marked reduction in the rate of synthesis of the major proteins alpha- and beta-tubulin. Our results indicate that the control of synthesis of these proteins during the differentiation event is exerted at the level of alpha- and beta-tubulin mRNA accumulation.
D000818:Animals; D002455:Cell Division; D004274:DNA, Recombinant; D005786:Gene Expression Regulation; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000235:genetics; D014349:Trypanosoma cruzi / Q000166:cytology / Q000235:genetics*; D014404:Tubulin / Q000235:genetics*
D004274:DNA, Recombinant; D012333:RNA, Messenger; D014404:Tubulin