[Transcutaneous measures of oxygen partial pressure and capillaroscopic parameters as affected by naftidrofuryl in patients with obliterative arteriopathies, Fontaine stages II-IV].
Transcutaneous partial oxygen pressure on dorsum of foot was determined and capillaroscopy of big toes performed before and after infusions of naftidrofuryl (200 mg/l/h) and of 5% levulose to 30 patients with obliterative arterial disease of lower limbs, stages II to IV (10 patients in each stage). Naftidrofuryl provoked an increase in cutaneous partial oxygen pressure of 26.8 to 36.4 mm Hg (p less than 0.001) whereas no significant change was noted after 5% levulose. In addition, density of visible capillaries increased from 23.5 to 26.1/mm2 with naftidrofuryl. Severe stages of ischemia, evaluated as described by Fagrell, were improved by naftidrofuryl treatment. These findings suggest a favorable action of naftidrofuryl on cutaneous microcirculation distal to arterial obliteration at all Fontaine's stages.
D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000188:drug therapy* / Q000503:physiopathology; D002196:Capillaries / Q000187:drug effects; D005260:Female; D005663:Furans / Q000627:therapeutic use*; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D009257:Nafronyl / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D012867:Skin / Q000098:blood supply; D014665:Vasodilator Agents / Q000627:therapeutic use*
D005663:Furans; D014665:Vasodilator Agents; D009257:Nafronyl; D010100:Oxygen
Mesures transcutanées de la pression partielle d'oxygène (Tc PO2) et paramètres capillaroscopiques sous naftidrofuryl dans les artériopathies oblitérantes de stade II-IV de Fontaine.