[Methylation of membrane phospholipids of alveolar macrophages in pulmonary sarcoidosis and diffuse interstitial pulmonary fibrosis].
Alveolar macrophage plays an important role in alveolitis pathogenesis and lung fibrosis process. Macrophages exhibit plasmic membrane biochemical modifications during cell activation. Phospholipid methylation is involved during plasmic membrane stimulation. Phosphatidylethanolamine methyltransferase I was measured in alveolar macrophage membrane from normal subjects and patients presenting with pulmonary sarcoidosis or interstitial lung fibrosis. We observed increased enzyme activity among sarcoidosis subjects with high intensity lung alveolitis and normal subjects receiving immunostimulating treatment (RU 41740). The role of membrane phospholipidic modifications in granulomatous process is discussed.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D008745:Methylation; D008875:Middle Aged; D010743:Phospholipids / Q000378:metabolism*; D011650:Pulmonary Alveoli / Q000166:cytology; D011658:Pulmonary Fibrosis / Q000378:metabolism; D012507:Sarcoidosis / Q000378:metabolism*
D008563:Membrane Lipids; D010743:Phospholipids
La méthylation des phospholipides membranaires du macrophage alvéolaire dans la sarcoïdose pulmonaire et les fibroses pulmonaires interstitielles diffuses.