title: Time-dose relationships for local tumor control and complications following irradiation of squamous cell carcinoma of the base of tongue.
abstract: Between October 1964 and September 1981, 114 previously untreated patients with squamous cell carcinoma of the base of the tongue were treated with curative intent by a radical course of irradiation at the University of Florida. With a minimum 2-year follow-up, local control was achieved in 78, 65, 76, and 17% of T1, T2, T3, and T4 lesions, respectively. Control results could be correlated with time-dose factors and treatment techniques. No patient required mandibulectomy for osteoradionecrosis following radiation therapy. Complications of bone and soft tissue could not be related to time-dose factors.
mesh_terms: D001842:Bone and Bones / Q000528:radiation effects; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D009061:Mouth Mucosa / Q000528:radiation effects; D011878:Radiotherapy / Q000009:adverse effects*; D014062:Tongue Neoplasms / Q000532:radiotherapy*