Reducing the hemorrhagic complications of hemodialysis: a controlled comparison of low-dose heparin and citrate anticoagulation.
We report a randomized prospective study comparing the results of anticoagulation using hypertonic trisodium citrate and low-dose controlled heparin during 45 hemodialysis treatments performed on patients determined to be at high or very high risk for bleeding. Dialysis-associated bleeding was more frequent following low-dose controlled heparin anticoagulation than during hypertonic citrate therapy (P less than .05). Dialysis effectiveness measured by postdialysis chemistries and weight loss was equivalent in the two groups.
D000925:Anticoagulants / Q000009:adverse effects*; D002951:Citrates / Q000009:adverse effects*; D019343:Citric Acid; D002986:Clinical Trials as Topic; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D011446:Prospective Studies; D011897:Random Allocation; D006435:Renal Dialysis
D000925:Anticoagulants; D002951:Citrates; D019343:Citric Acid; D006493:Heparin