[Interdependence of the cell cycles of mammalian sister cells in monolayer cultures detected through their desynchronization by UV microirradiation].
The duration and variability of cell cycles in epithelial and fibroblast-like mammalian sister cells with different types of intercellular contacts were estimated using time-lapse cinemicrographic technique. To study a possible interrelation between cell cycles of the sister cells, one cell in each pair of sister cells was inactivated by selective UV microbeam irradiation at the beginning of its cell cycle. It is shown that this action may delay the cycle of the intact cell as well. Such an interrelation of sister cells was found only at the G1 phase of the cell cycle and only in epithelial cells.
D000818:Animals; D002450:Cell Communication / Q000528:radiation effects*; D002453:Cell Cycle / Q000528:radiation effects*; D002460:Cell Line; D002478:Cells, Cultured; D004847:Epithelial Cells; D004848:Epithelium / Q000528:radiation effects; D005347:Fibroblasts / Q000166:cytology / Q000528:radiation effects; D007399:Interphase / Q000528:radiation effects; D051379:Mice; D013552:Swine; D013997:Time Factors; D014466:Ultraviolet Rays
Vzaimozavisimost' kletochnykh tsiklov sestrinskikh kletok mlekopitaiushchikh v monosloĭnoĭ kul'ture, vyiavliaemaia pri ikh desinkhronizatsii UF-mikrooblucheniem.