[Use of germ-free mice in experimental transplantation].
A comparative study of skin allografts was performed in germ-free A/Ola mice kept in boxes and in A/Ola and BALB mice raised in ordinary conditions. Skin graft (of C57B1/6 mice) in A/Ola and BALB mice raised in ordinary conditions was shown to reject 16-21 and 12-18 days after the transplantation, respectively without cyclophosphamide (CP) use. CP application in BALB mice, grown in ordinary conditions, prolonged the lifespan of grafts to 12-29 days. The use of CP in germ-free A/Ola mice prolonged the lifespan of grafts to 19-39 days. In germ-free mice kept in boxes the use of an immunodepressant was not accompanied by infectious complications, while the animals kept in the vivarium often died of infectious diseases.
D000818:Animals; D005856:Germ-Free Life; D006799:Housing, Animal; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D016038:Skin Transplantation; D014181:Transplantation Immunology
Ispol'zovanie mysheĭ, svobodnykh ot patogennoĭ flory, v éksperimental'noĭ transplantologii.