Human renin inhibiting dipeptide.
KRI-1177, a dipeptide containing nor-statine inhibited renin activity in human and Japanese monkey plasma to a markedly greater extent than that in dog, rabbit and rat plasma. The systemic blood pressure of anesthetized monkeys was lowered by intravenous injections of this compound which also reduced plasma renin activity and concentration of angiotensins. KRI-1177 appears to selectively inhibit primate renin activity, thereby producing hypotension.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004151:Dipeptides / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008251:Macaca; D008297:Male; D011817:Rabbits; D051381:Rats; D012083:Renin / Q000097:blood; D000092502:Renin Inhibitors
D004151:Dipeptides; D012083:Renin; D000092502:Renin Inhibitors; C051028:KRI 1177