Oxalate depuration during biofiltration with AN69 and in conventional hemodialysis in chronic renal failure (CRF) patients.
Oxalate (Ox), an end product of amino acid metabolism, accumulates in CRF patients as calcium crystal deposits in many soft tissues such as myocardium, kidney interstitium, etc. Since BF employs AN69, a high efficiency membrane, we tested its depurative efficacy for Ox against a hollow-fiber cuprophan dialyzer. Five CRF patients previously in HD and after six months of BF were studied. End-dialysis and pre-dialysis Ox values and dialyzer clearance were obtained. Predialysis Ox values were: 0.44 +/- 0.15 mg/dl in HD and 0.42 +/- 0.09 mg/dl in BF (NS). End-dialysis Ox values were: 0.30 +/- 0.09 mg/dl in HD and 0.22 +/- 0.04 mg/dl in BF (p less than 0.001). Pre and post dialysis values differed by 31% in HD and 47% in BF (p less than 0.001). Ox clearance was 98.8 +/- 10.3 ml/min in HD and 143 +/- 20.5 ml/min in BF. There was a rebound in Ox values at 48 hours (0.41 +/- 0.08 mg/dl in HD and 0.32 +/- 0.12 mg/dl in BF, (NS). These results indicate that Ox is depurated better during BF than during HD.
D000180:Acrylic Resins; D000181:Acrylonitrile / Q000031:analogs & derivatives; D001769:Blood; D003404:Creatinine / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008567:Membranes, Artificial; D009570:Nitriles; D010070:Oxalates / Q000097:blood*; D006435:Renal Dialysis; D014462:Ultrafiltration / Q000295:instrumentation / Q000379:methods*
D000180:Acrylic Resins; D008567:Membranes, Artificial; D009570:Nitriles; D010070:Oxalates; C016892:AN-69; D003404:Creatinine; D000181:Acrylonitrile