title: Receptor binding of corticosterone in some rat brain structures following neonatal blockade of the hypophyseoadrenal system.
abstract: Administration of hydrocortisone to rats during the first five postnatal days leads to the blockade of the hypophyseoadrenal system and results in a decrease in the number of corticosterone receptors in the hypophysis, hypothalamus, and hippocampus. Such a decrease in the receptor binding of corticosterone in the brain structures involved in the regulation of the hypophyseoadrenal system by a feedback mechanism is due to a change in the number of true glucocorticoid receptors.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003345:Corticosterone / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology; D007031:Hypothalamus / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D011987:Receptors, Steroid
chemical_list: D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; C024357:corticosterone receptor; D003345:Corticosterone; D006854:Hydrocortisone