On the cross-coupling reaction of 1,3-dimethylthymine and thymidine epoxides with nucleophiles.
Solvent effect in reaction of 1,3-dimethylthymine epoxide (1) with amines was investigated. The results are summarized in Table I, indicating that the ratio of formation of the cis product (2) increases as a solvent becomes more polar. Reaction of thymidine epoxide (5) with nucleophiles was also examined.
D000596:Amino Acids; D055598:Chemical Phenomena; D002621:Chemistry; D004852:Epoxy Compounds; D007202:Indicators and Reagents; D011687:Purines; D013329:Structure-Activity Relationship; D013936:Thymidine / Q000031:analogs & derivatives*; D013941:Thymine / Q000031:analogs & derivatives*
D000596:Amino Acids; D004852:Epoxy Compounds; D007202:Indicators and Reagents; D011687:Purines; C047919:1,3-dimethylthymine epoxide; D013941:Thymine; D013936:Thymidine