The effect of copper ions in vivo on specific hormonal endometrial receptors.
A comparative randomized study was made of three intrauterine contraceptive devices: the Nova-T, MLCu250 Short and MLCu375. An endometrial biopsy was performed on the 25th day of the menstrual cycle before and after IUD insertion. The tissue obtained was analyzed to determine estrogen and progesterone receptor concentration and endometrial morphology patterns in IUD users. Both estrogen and progesterone receptors decreased proportionally to the increased amount of copper in the IUD. The histologic study showed changes in endometria relative to the amount of copper, but these changes were transitory and disappeared after a year of IUD use.
D000328:Adult; D002986:Clinical Trials as Topic; D003300:Copper / Q000494:pharmacology*; D004717:Endometrium / Q000166:cytology / Q000187:drug effects*; D005260:Female; D006801:Humans; D007435:Intrauterine Devices, Copper; D011897:Random Allocation; D011960:Receptors, Estrogen / Q000187:drug effects*; D011980:Receptors, Progesterone / Q000187:drug effects*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D003300:Copper