Hepatic effects of acetaminophen. Enhanced toxicity in alcoholics.
Alcoholic patients run an increased risk of developing hepatotoxicity from doses of acetaminophen within or only moderately above the recommended usual therapeutic doses. In this review I examine the scientific evidence and clinical observations that indicate such a heightened susceptibility of the alcoholic to acetaminophen-induced injury.
D000082:Acetaminophen / Q000009:adverse effects* / Q000378:metabolism; D000437:Alcoholism / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008107:Liver Diseases / Q000378:metabolism; D012306:Risk
D000082:Acetaminophen; D000431:Ethanol