Beneficial effects of danazol on symptoms and laboratory changes in cholinergic urticaria.
In a double-blind placebo-controlled study, danazol, an attenuated androgen, was effective in reducing exercise-induced weals in cholinergic urticaria. Danazol treatment also caused significant elevations of several protease inhibitors, particularly antichymotrypsin which has been reported previously to be low in cholinergic urticaria.
D000293:Adolescent; D000328:Adult; D002799:Cholinergic Fibers / Q000187:drug effects; D002986:Clinical Trials as Topic; D003613:Danazol / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D011245:Pregnadienes / Q000627:therapeutic use*; D011480:Protease Inhibitors / Q000097:blood; D011897:Random Allocation; D014581:Urticaria / Q000097:blood / Q000188:drug therapy*
D011245:Pregnadienes; D011480:Protease Inhibitors; D003613:Danazol