title: Clear cell chondrosarcoma. A report of two cases and review of literature.
abstract: Two cases of clear cell chondrosarcoma located in the distal femur and proximal humerus are reported. Both patients were men aged 35 and 51 years. Their initial symptom was a pathologic fracture. Roentgenographically, one patient showed a purely lytic lesion and another lytic with centrally radiodensity. Microscopic examination revealed that the tumor cells have a centrally placed vesicular nucleus surrounded by a clear cytoplasm, with distinct boundaries. Their cytoplasm stained with S-100 protein by the peroxidase-antiperoxidase method. We found 36 reported cases (including the two reported here), and delineated the clinico-pathologic characteristics of the disease.
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000032:analysis* / Q000000981:diagnostic imaging / Q000473:pathology; D002813:Chondrosarcoma / Q000032:analysis* / Q000000981:diagnostic imaging / Q000473:pathology; D005266:Femoral Neoplasms / Q000032:analysis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006811:Humerus; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D011859:Radiography; D009418:S100 Proteins / Q000032:analysis*
chemical_list: D009418:S100 Proteins