Hodgkin disease: malignancy, inflammation and abnormal immunity.
The effect of Hodgkin disease cells on the surrounding environment is complex. In the light of recent findings on growth factors and oncogenes a hypothesis on Hodgkin disease is presented. The interrelation of three main features of Hodgkin disease: malignancy, inflammation and abnormal immunity may be explained by the local secretion of platelet-derived growth factor like substances and interleukin-1 like substances by malignant Hodgkin disease cells.
D002450:Cell Communication; D006689:Hodgkin Disease / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007111:Immunity, Cellular; D007249:Inflammation / Q000150:complications; D009361:Neoplasm Invasiveness; D010982:Platelet-Derived Growth Factor / Q000378:metabolism
D010982:Platelet-Derived Growth Factor