Five-year survey of changing patterns of susceptibility of bacterial uropathogens to trimethoprim-sulfamethoxazole and other antimicrobial agents.
We analyzed the antibiotic susceptibility of 5,348 urinary isolates of Escherichia coli, "Klebsiella aerogenes," and Proteus mirabilis grown in three laboratories from 1980 to 1985. A continuous rise in resistance to trimethoprim-sulfamethoxazole was observed; 63% of the strains from inpatients in 1984 and 51% of those from outpatients in 1985 were resistant to this drug. Isolates from outpatients in 1985 were mostly susceptible to nitrofurantoin (mean susceptibility, 92%) and to oral cephalosporins (mean susceptibility, 84%). As for isolates from inpatients, none of the antimicrobial agents now used was satisfactory for initial chemotherapy, indicating a need for new antibacterial strategies.
D000667:Ampicillin / Q000494:pharmacology; D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology*; D001437:Bacteriuria / Q000382:microbiology*; D002511:Cephalosporins / Q000494:pharmacology; D004338:Drug Combinations / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D007709:Klebsiella / Q000187:drug effects / Q000302:isolation & purification; D009582:Nitrofurantoin / Q000494:pharmacology; D010403:Penicillin Resistance; D011513:Proteus mirabilis / Q000187:drug effects / Q000302:isolation & purification; D013420:Sulfamethoxazole / Q000494:pharmacology*; D013997:Time Factors; D014295:Trimethoprim / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000892:Anti-Infective Agents, Urinary; D002511:Cephalosporins; D004338:Drug Combinations; D000667:Ampicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D009582:Nitrofurantoin; D014295:Trimethoprim; D013420:Sulfamethoxazole