[The serotoninergic component in the mechanism of the development of neurogenic damage to the stomach].
The involvement of the serotoninergic system in the development of neurogenic gastric lesions induced by the three-hour electrical stimulation of the immobilized rats was shown. Serotonin (0.4 mg/kg) and d,1-5-hydroxytryptophan (50 mg/kg) failed to prevent the development of neurogenic gastric lesions. Deseril (0.5 mg/kg) and BC-105 (1 mg/kg) significantly decreased the formation of hemorrhagic erosions and prevented a decrease of serotonin and norepinephrine levels as well as creatine phosphate content in the stomach tissue.
D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D005753:Gastric Mucosa / Q000378:metabolism; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012149:Restraint, Physical; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects; D013276:Stomach Ulcer / Q000209:etiology* / Q000378:metabolism; D013997:Time Factors
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin; D008995:Monoamine Oxidase
Serotoninergicheskiĭ komponent v mekhanizme razvitiia neĭrogennogo povrezhdeniia zheludka.