Prevalence of ras gene mutations in human colorectal cancers.
A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.
D000236:Adenoma / Q000235:genetics / Q000473:pathology; D002277:Carcinoma / Q000235:genetics / Q000473:pathology; D003062:Codon; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology; D004247:DNA / Q000235:genetics; D006801:Humans; D009154:Mutation; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D012004:Rectal Neoplasms / Q000235:genetics* / Q000473:pathology
D003062:Codon; D004247:DNA