Influenza specific antibodies in the female genital tract of mice after oral administration of live influenza vaccine.
In order to investigate the possible stimulation of antibodies in the genital tract by immunization female NMRI-mice were given orally a live influenza vaccine (A/PR/8/34, H1N1) on two occasions which were 10 days apart. Subsequently, virus specific IgA antibodies measured by an enzyme immunoassay in homogenates of urinary bladder, uterus and vagina and also in uterine washings. Specific IgA antibodies were not detectable in the sera of immunized mice. The high IgA titer in uterine washings, and in the homogenates suggests enhancement by vaccine of IgA antibody production in the genital tract.
D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D005260:Female; D007070:Immunoglobulin A / Q000032:analysis; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D051379:Mice; D014566:Urogenital System / Q000276:immunology*
D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007252:Influenza Vaccines