title: Peroxisomal localization and activation by bivalent metal ions of ureidoglycolate lyase, the enzyme involved in urate degradation in Candida tropicalis.
abstract: Ureiodoglycolate lyase (EC 4.3.2.3) was found only in the peroxisomes in urate-induced Candida tropicalis. The enzyme was markedly activated by the bivalent metal ions Mn2+, Fe2+, and Ni2+. The activation by Mn2+ was suggested to be the result of its binding to the apoenzyme.
mesh_terms: D019760:Amidine-Lyases; D002175:Candida / Q000201:enzymology*; D002413:Cations, Divalent; D004789:Enzyme Activation / Q000187:drug effects; D008190:Lyases / Q000378:metabolism*; D008830:Microbodies / Q000201:enzymology; D014503:Urate Oxidase / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism*
chemical_list: D002413:Cations, Divalent; D014527:Uric Acid; D014503:Urate Oxidase; D008190:Lyases; D019760:Amidine-Lyases; C033757:ureidoglycollate lyase