Antibiotic penetration into rabbit nucleus pulposus.
A rabbit model was used to determine the penetration of four commonly used antibiotics (clindamycin, tobramycin, cephalothin, and oxacillin) into the nucleus pulposus after receiving an 8-hour course of intramuscular antibiotic injections. Clindamycin and tobramycin achieved therapeutic levels in the nucleus pulposus and both were present in greater than 50% of serum levels. Cephalothin was not detected in the nucleus pulposus and penetrated at less than 4% of serum levels at 1 hour after injection. The data were inconclusive regarding oxacillin penetration.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002512:Cephalothin / Q000378:metabolism; D002981:Clindamycin / Q000378:metabolism; D007273:Injections, Intramuscular; D007403:Intervertebral Disc; D010068:Oxacillin / Q000378:metabolism; D011817:Rabbits; D014031:Tobramycin / Q000378:metabolism
D000900:Anti-Bacterial Agents; D002981:Clindamycin; D002512:Cephalothin; D010068:Oxacillin; D014031:Tobramycin