Interferon-beta can induce the production of plasminogen activator by cultured human cancer cells.
Three cultured human cell lines, renal cancer cells (ACHN), bladder cancer cells (EJ), and fibroblasts transformed in culture by Co-60 gamma rays (KMST-6), when treated with interferon-beta, produced 1.5 to 4 times as much plasminogen activator as the untreated control cultures. This enhanced production of PA was inhibited by cycloheximide or actinomycin D.
D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D006801:Humans; D007370:Interferon Type I / Q000502:physiology*; D007680:Kidney Neoplasms / Q000378:metabolism; D007700:Kinetics; D009369:Neoplasms / Q000378:metabolism*; D009381:Neoplasms, Radiation-Induced / Q000378:metabolism; D010960:Plasminogen Activators / Q000096:biosynthesis*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism
D007370:Interferon Type I; D003609:Dactinomycin; D003513:Cycloheximide; D010960:Plasminogen Activators