[Cytogenetic effect of natural mutagenesis modifiers in a human lymphocyte culture. The action of caffeine during the induction of chromosome aberrations by gibberellic acid].
Caffeine sensibilization of the cytogenetic activity of gibberellic acid in the culture of human lymphocytes was investigated. A four-five-fold increase in the level of chromosome aberrations by addition of caffeine into the culture with gibberellic acid on the 29th, 46th and 72nd hour of cultivation was revealed. Application of sensitizers of the chemical mutagens' action is recommended to study weak mutagenic activity of chemicals in routine test systems.
D002110:Caffeine / Q000494:pharmacology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005875:Gibberellins / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008677:Metaphase / Q000187:drug effects; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000494:pharmacology*; D013997:Time Factors
D005875:Gibberellins; D009153:Mutagens; D002110:Caffeine; C007842:gibberellic acid
Tsitogeneticheskiĭ éffekt estestvennykh modifikatorov mutageneza v kul'ture limfotsitov cheloveka. Deĭstvie kofeina pri induktsii aberratsiĭ khromosom gibberellovoĭ kislotoĭ.