[Reception of sucrose in the small intestine after monoamine oxidase and beta-adrenoreceptor block].
In anesthetized cats, potentials of longitudinal muscles of the middle small intestine and impulses of afferent fibers of mesenteric nerves were recorded. Effects of 1-M sucrose solution prior to and after i.v. administration of the MAO blockers and obsidan (beta-adrenoceptor blocker) were compared. After simultaneous blockade of the MAO and the beta-adrenoreceptors, the duration of excitatory effect on smooth muscles induced by intraluminal sucrose administration increased. The pulse rate of mesenteric nerves, with a declining initial background observed as a result of the MAO and the beta-adrenoreceptor blockers action, increased within 25 min after sucrose administration. A hypothesis of the involvement of serotonin of the small intestine mucose entero-chromaffin cells in the primary perception of sugars, is suggested.
D000818:Animals; D002415:Cats; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004594:Electrophysiology; D005260:Female; D007421:Intestine, Small / Q000187:drug effects*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D009130:Muscle, Smooth / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology*; D013153:Splanchnic Nerves / Q000502:physiology*; D013395:Sucrose / Q000494:pharmacology*
D004040:Dietary Carbohydrates; D012701:Serotonin; D013395:Sucrose; D011433:Propranolol; D008995:Monoamine Oxidase; D009638:Norepinephrine
Retseptsiia sakharozy v tonkoĭ kishke posle bloka monoaminoksidazy i beta-adrenoretseptorov.