Primidone-carbamazepine interaction: clinical consequences.
A 15-year old boy, suffering from partial complex seizures, was treated with primidone (PR) and carbamazepine (CBZ). In spite of daily doses in the usual range (PR = 12 mg/kg, CBZ = 30 mg/kg), he was not free from seizures and serum levels of CBZ were remarkably low (4.8 micrograms/ml). A good control of seizures was obtained after gradually stopping treatment with PR. This lead to a substantial increase of CBZ serum levels to a decrease of carbamazepine-10, 11-epoxide levels and a 60% reduction in total CBZ clearance.
D000293:Adolescent; D002220:Carbamazepine / Q000097:blood* / Q000627:therapeutic use; D004347:Drug Interactions; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011324:Primidone / Q000627:therapeutic use*
D011324:Primidone; D002220:Carbamazepine