Target regions enhance the outgrowth and survival of ganglion cells in embryonic retina transplanted to cerebral cortex in neonatal rats.
In embryonic mouse retina transplanted to occipital cortex of neonatal rats, ganglion cells do not project axons into the host cortex, although they may survive up to but not beyond 6 weeks post-transplantation. By contrast, if embryonic tectum or diencephalon is transplanted along with the retina, ganglion cells exhibit vigorous outgrowth to specific regions of the co-transplant and are able to survive for at least 14 weeks.
D000367:Age Factors; D000818:Animals; D001369:Axons / Q000502:physiology; D002454:Cell Differentiation; D004027:Diencephalon / Q000502:physiology / Q000637:transplantation; D051379:Mice; D009473:Neuronal Plasticity; D009778:Occipital Lobe / Q000502:physiology* / Q000601:surgery; D051381:Rats; D012160:Retina / Q000196:embryology / Q000502:physiology* / Q000637:transplantation*; D012165:Retinal Ganglion Cells / Q000502:physiology*; D013477:Superior Colliculi / Q000502:physiology / Q000637:transplantation; D014183:Transplantation, Heterologous