title: Effect of rifampin and its cyclopentyl analogue, MDL 473, on the expression of delayed type hypersensitivity to oxazolone.
abstract: The purpose of this study was to determine the effect of rifampin and its cyclopentyl analogue, MDL 473, on delayed type hypersensitivity (DTH) using a murine model. Neither compound has any significant effect on DTH (as measured by ear swelling) to oxazolone when administered i.p. to BALB/c mice at doses of 1, 10, 50 or 100 mg/kg beginning 3 days before oxazolone sensitization and continuing until hapten challenge 5 days later. In contrast, sex and age matched controls receiving 200 mg hydrocortisone/kg i.p. beginning on the day of oxazolone sensitization and continuing to hapten challenge demonstrate a significant (P less than 0.001) abrogation of DTH.
mesh_terms: D000818:Animals; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000188:drug therapy* / Q000209:etiology; D051379:Mice; D008807:Mice, Inbred BALB C; D010081:Oxazolone / Q000276:immunology; D012293:Rifampin / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D010081:Oxazolone; D012293:Rifampin; D006854:Hydrocortisone; C018421:rifapentine