title: Precluding coccidiosis with an anti-coprophagia drug.
abstract: Floor-pen studies were conducted to ascertain whether coccidiosis could be prevented by using a drug added to the litter to preclude coprophagia and ingestion of infective oocysts. An experimental drug (1-pyrrolidinebutyramide, 2-methyl-alpha,alpha-diphenyl) was added to litter contaminated with sporulated Eimeria tenella oocysts. Thereafter 7-day-old broiler chicks were reared on the litter for a nine-day period. Mortality, lesion scores and dropping scores were the criteria selected to determine efficacy. Treatment of the litter at the lowest level (2.3 g kg-1) did not reduce the incidence or severity of the disease, whereas treatment at two higher levels (11.5 and 23.0 g kg-1) significantly reduced both (incidence and severity). The highest level was the most efficacious; however, drug toxicity was also encountered at this level.
mesh_terms: D000818:Animals; D002645:Chickens / Q000469:parasitology*; D003048:Coccidiosis / Q000517:prevention & control / Q000662:veterinary*; D003303:Coprophagia / Q000517:prevention & control*; D005260:Female; D006799:Housing, Animal; D008297:Male; D011201:Poultry Diseases / Q000517:prevention & control*; D011759:Pyrrolidines / Q000627:therapeutic use*; D011897:Random Allocation
chemical_list: D011759:Pyrrolidines; C051747:1-pyrrolidinebutyramide-2-methyl-alpha,alpha-diphenyl