Lipid-A-antibodies--indicators for the risk of renal scarring in children with urinary tract infection.
The levels of IgG- and IgM-antibodies against lipid A were determined by an ultramicro-ELISA in 54 children between 2 months and 13 years of age with non-obstructive urinary tract infections at the onset of the infection and subsequently after 3, 6 and 12 months. Children older than 2 years who later developed renal scarring as shown by intravenous pyelograms had higher levels of IgG antibodies than those without scars. This correlation was not found in children younger than 2 years of age. IgM-antibody levels did not correlate with the risk of scar formation. We conclude that the IgG-antibody level against lipid A is a useful indicator for early recognition of children over the age of two years who will later develop renal scars. The ultramicro-ELISA technique makes screening for children at risk possible at a low cost.
D000293:Adolescent; D001424:Bacterial Infections / Q000150:complications / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007223:Infant; D007674:Kidney Diseases / Q000209:etiology*; D008050:Lipid A / Q000276:immunology*; D008297:Male; D011704:Pyelonephritis / Q000150:complications / Q000276:immunology; D012306:Risk; D014552:Urinary Tract Infections / Q000150:complications / Q000276:immunology*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008050:Lipid A