title: Osteoporosis, calcium requirement, and factors causing calcium loss.
abstract: A large percentage of subjects receiving a normal calcium intake of 800 mg per day was in negative calcium balance and increasing the calcium intake to various levels up to 2200 mg per day showed a plateau of the calcium balance at the 1200 mg per day intake, indicating a threshold of calcium absorption at this intake level. Dietary factors, such as a phosphorus intake up to 2000 mg per day and complex proteins, such as red meat, do not cause calcium loss. Several commonly used drugs induce significant calcium loss, particularly aluminum-containing antacids, and, if used for prolonged periods of time, can contribute to the development of osteoporosis.
mesh_terms: D000328:Adult; D000368:Aged; D000863:Antacids / Q000009:adverse effects; D002118:Calcium / Q000378:metabolism*; D002136:Calcium, Dietary / Q000008:administration & dosage*; D004032:Diet; D004044:Dietary Proteins / Q000008:administration & dosage; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism; D009751:Nutritional Requirements; D010024:Osteoporosis / Q000209:etiology*; D010758:Phosphorus / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D000863:Antacids; D002136:Calcium, Dietary; D004044:Dietary Proteins; D008903:Minerals; D010758:Phosphorus; D000431:Ethanol; D002118:Calcium