Dysproteinuria induced in rats by O,O,S-trimethyl phosphorothioate.
Administration of a single oral dose of 60 mg/kg O,O,S-trimethyl phosphorothioate (OOS-Me), a malathion impurity, resulted in a substantial increase in the amounts of amino acids along with a change in the nature of proteins excreted in the urine of treated rats. In contrast to control rats, a small increase in albumin and a small decrease in alpha 1-globulin were observed. However, alpha2-, beta- and gamma 1-globulin, which were not detected in the urine of control rats, were found in substantial amounts in the urine of OOS-Me-treated rats. These findings, coupled with observed increases in urinary glucose levels and consistent specific gravity readings of 1.01 even though treated rats were experiencing oliguria, provide evidence for OOS-Me-induced kidney tubule damage.
D000419:Albuminuria / Q000139:chemically induced; D000596:Amino Acids / Q000652:urine; D000818:Animals; D004587:Electrophoresis, Agar Gel; D005916:Globulins / Q000652:urine; D008297:Male; D063086:Organothiophosphates / Q000494:pharmacology / Q000633:toxicity*; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D011507:Proteinuria / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D005916:Globulins; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; C023890:O,O,O-trimethyl phosphorothioate; C019123:O,O,S-trimethyl phosphorothioate