Concentration of norfloxacin in human gallbladder tissue and bile after single-dose oral administration.
Concomitant concentrations of norfloxacin in serum and in gallbladder tissue and bile were determined in 10 patients after a single oral dose of 400 mg given before cholecystectomy. Concentrations in gallbladder bile ranged from 0.6 to 15.6 micrograms/ml, with a mean bile/serum ratio of 7.0. The mean concentration in gallbladder tissue was 1.8 +/- 0.8 (standard error) micrograms/g.
D000328:Adult; D000368:Aged; D001646:Bile / Q000378:metabolism*; D005260:Female; D005704:Gallbladder / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009643:Norfloxacin / Q000378:metabolism*; D014018:Tissue Distribution
D009643:Norfloxacin