Bone fracture in elderly female with primary hyperparathyroidism: relationship among renal function, vitamin D status and fracture risk.
Among 12 aged postmenopausal females with primary hyperparathyroidism, 5 had no bone fracture and 7 had fractures. Both serum 1,25 (OH)2D levels and creatinine clearance values in patients with fracture were significantly lower than those without fracture (p less than 0.025). In addition, significant positive correlation was observed between serum 1,25 (OH)2D levels and creatinine clearance values (p less than 0.05). These data suggest that decreased serum 1,25 (OH)2D level due to renal dysfunction may causally correlate to bone fracture in postmenopausal primary hyperparathyroidism.
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology*; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000150:complications*; D007668:Kidney / Q000503:physiopathology*; D008875:Middle Aged; D012306:Risk; D014807:Vitamin D / Q000097:blood*
D014807:Vitamin D