[Neurospecific and neuron-specific enolase levels in human nerve tissue at early stages of embryogenesis].
Neurospecific and neuro-nonspecific isozymes of glycolytic enzyme enolase known to be molecular markers of neuronal and glial cells respectively were isolated from human brain. Using immunoenzyme assay, the content of these proteins was measured in the brain of 7-13-week human embryos and adult subjects. The content of both isoenzymes gradually increases attaining constant level in 10-13-week embryos. Relative content of neuro-nonspecific enolase in the brain of 10-13-week embryos is 1 1/2 times higher than that in adults, whereas the content of neurospecific enolase amounts only to 2% of its level in the adult brain.
D001921:Brain / Q000196:embryology* / Q000201:enzymology; D002852:Chromatography, Ion Exchange; D004622:Embryo, Mammalian / Q000201:enzymology*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*
D007527:Isoenzymes; D010751:Phosphopyruvate Hydratase
Soderzhanie neĭrospetsificheskoĭ i neĭronspetsificheskoĭ enolazy v nervnoĭ tkani cheloveka na rannikh stadiiakh émbriogeneza.