title: Brachygnathia superior and degenerative joint disease: a new lethal syndrome in Angus calves.
abstract: Brachygnathia superior and generalized diarthrodial degenerative joint disease were seen in 17 related, purebred Angus calves ranging in age from 2 days to 4 months. Craniometrical studies revealed decreased maxillary and palatine bone lengths and increased cranial, skull, and facial indices. Radiological evaluation of major appendicular joints demonstrated lipping of the joint margins with osteophyte formation, sclerosis of subchondral bone, and narrowing of joint spaces. Synovial fluid evaluation indicated joint degeneration but no etiologic agent. Rheumatoid factor analysis of plasma was negative. Grossly, all major appendicular joints were defective including the atlanto-occipital articulation. Lesions ranged from loss of surface luster to erosions and deep ulcers with eburnation of the subchondral bone and secondary proliferative synovitis. Histological changes were degeneration of the articular cartilage matrix, chondrocyte necrosis, flaking and fibrillation, chondrone formation, erosions and ulcers of the articular cartilage with subchondral bone sclerosis, vascular invasion with fibrosis, and chronic, nonsuppurative, proliferative synovitis. Growth plates had defective chondrocyte proliferation and hypertrophy with aberrant ossification of calcified cartilaginous matrix. Histochemical analysis of cartilage and bone failed to incriminate which component was defective, glycosaminoglycan or collagen, but indicated different distribution or absence of one or the other. Genealogic studies revealed a genetic basis for the new defect.
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology; D002417:Cattle; D002418:Cattle Diseases / Q000151:congenital* / Q000235:genetics / Q000473:pathology; D002508:Cephalometry; D005260:Female; D006132:Growth Plate / Q000473:pathology; D006651:Histocytochemistry; D007592:Joint Diseases / Q000151:congenital / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008437:Maxilla / Q000002:abnormalities*; D010375:Pedigree; D012886:Skull / Q000002:abnormalities; D013577:Syndrome / Q000662:veterinary; D013582:Synovial Fluid / Q000032:analysis