Alveolar hemorrhage associated with a membranoproliferative glomerulonephritis and smooth muscle antibody.
Alveolar hemorrhage along with glomerulonephritis developed in a 31-year-old black man. Renal biopsy demonstrated a granular pattern of immunofluorescence along basement membrane glomeruli, suggesting an immunologically mediated illness; however, light microscopy revealed a pure membranoproliferative glomerulonephritis, which has not been described to date in association with the alveolar hemorrhage syndromes. The patient's immunologic profile revealed a positive antinuclear antibody titer along with the presence of smooth muscle antibodies.
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D005921:Glomerulonephritis / Q000276:immunology*; D006470:Hemorrhage / Q000276:immunology*; D006801:Humans; D008171:Lung Diseases / Q000276:immunology*; D008297:Male; D009130:Muscle, Smooth / Q000276:immunology*; D011650:Pulmonary Alveoli
D000906:Antibodies