Metabolic alkalosis following administration of an organophosphorus compound, O,S,S-trimethyl phosphorodithioate.
The oral administration of a single dose of O,S,S-trimethyl phosphorodithioate (OSSMe) to rats was found to result, 24 hours after treatment, in a dose-related metabolic alkalosis. Non-invasive indices of kidney damage revealed that during the first 4 hours after OSSMe administration there was a fourfold increase in urine flow with increases in albumin, beta 2-microglobulin and N-acetyl-glucosaminidase excretion. These results suggest that OSSMe-induced metabolic alkalosis may result from early renal functional disturbances.
D000110:Acetylcholinesterase / Q000378:metabolism; D000471:Alkalosis / Q000139:chemically induced*; D000818:Animals; D001784:Blood Gas Analysis; D001921:Brain / Q000201:enzymology; D004798:Enzymes / Q000652:urine; D063086:Organothiophosphates / Q000633:toxicity*; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains
D004798:Enzymes; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; C033125:O,S,S-trimethyl phosphorodithioate; D000110:Acetylcholinesterase