[Chronopharmacological and pharmacokinetic evaluation of the therapeutic effect of naproxen in rheumatoid arthritis].
Patients with exacerbation of rheumatoid arthritis without antiinflammatory therapy demonstrated no regular circadian variations in clinical-laboratory indices of disease activity. A study of the therapeutic effect of 3 schemes with naproxen has shown that one should consider the time of development of maximum arthralgia in each individual patient and administer the drug 1 hour before it at quite a large single dose. The drug concentration in the blood plasma of the rheumatoid arthritis patients corresponded, on an average, to an administered dose showing no parallelism with a clinical effect of the drug.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000097:blood / Q000627:therapeutic use*
D009288:Naproxen
Opyt khronofarmakologicheskoĭ i farmakokineticheskoĭ otsenki lechebnogo éffekta naproksena pri revmatoidnom artrite.