title: [The effect of ratibol, retabolil and solasodin on the blood coagulation system].
abstract: It has been established that ratibol, retabolil and solasodin in doses 5 and 10 mg/kg proved to have a slight anticoagulative effect. The same effect has been observed during 20 days of oral retabolil and solasodin intake. Ratibol was characterized by a two-step action. All three steroids activated factors II, VII, XIII and diminished factor I concentration. These changes were accomplished with the fall of antithrombin activity and decrease in resistance to streptokinase. The fibrinolysis level has been raised under the effect of the steroids studied.
mesh_terms: D000737:Androstenols / Q000494:pharmacology*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077603:Nandrolone Decanoate; D011517:Prothrombin Time; D011817:Rabbits; D012991:Solanaceous Alkaloids / Q000494:pharmacology*
chemical_list: D000737:Androstenols; D012991:Solanaceous Alkaloids; C052440:ratibol; D009277:Nandrolone; D000077603:Nandrolone Decanoate; C012037:solasodine
vernacular_title: Vliianie ratibola, retabolila i solasodina na sistemu svertyvaniia krovi.