Vasospastic phenomena on the luminal replica of rat brain vessels.
Strikingly localized ring-like constrictions (other than sphincters, cushions and offshoot furrows) have appeared on the casted vessels of some of our preparations. Morphology of the phenomena reveals diverse degree of active contraction of the vessel wall, ranging from corrugation of the luminal surface to near severance of the acrylic cast. Distribution of the vasospastic phenomena reveals as particularly affected the arteries in the diameter range between 25 and 75 micron, that belong either to intra-arterial anastomoses between the branches of each of the three major cerebral arteries or to their terminal junctions in the border zones (inter-arterial anastomoses). Among the possible causes for the occurrence of the observed vasospasms, we indicate the susceptibility to raised intraluminal pressure during injection, producing contraction of the smooth muscle cell. Reactivity appears heightened in the anastomotic districts of the circulation. The evidence of so-called "plastic strips" clinging to constricted sections of affected vessels prompts re-examination of their proposed origin as "plastic wrapping". Rather, they appear to be remnants of dynamic elements of the vascular wall (smooth muscle cells) that resisted corrosion.
D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D002560:Cerebrovascular Circulation; D004727:Endothelium / Q000648:ultrastructure; D005260:Female; D002546:Ischemic Attack, Transient / Q000473:pathology*; D008297:Male; D008833:Microcirculation / Q000648:ultrastructure*; D008855:Microscopy, Electron, Scanning; D008953:Models, Anatomic; D051381:Rats; D011919:Rats, Inbred Strains