Arizonins, a new complex of antibiotics related to kalafungin. II. Isolation and characterization.
A new complex of anti-Gram-positive antibiotics was produced by the fermentation of Actinoplanes arizonaensis sp. nov. The antibiotics were recovered from the fermentation broth with Amberlite XAD-7 resin and from the mycelium by acetone lysis. UV, IR, MS and NMR spectral studies characterized these compounds as kalafungin-type antibiotics. They differ from other known members by an unusual oxidation pattern on the aromatic ring. They vary from one another by the degree and position of O-methylation on the aromatic ring and in the aliphatic portion of the molecules. The structure of one component was confirmed by X-ray diffraction analysis.
D000192:Actinomycetales / Q000254:growth & development*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D009285:Naphthoquinones / Q000302:isolation & purification*; D009904:Optical Rotation; D013329:Structure-Activity Relationship; D000095622:Benzoisochromanequinones
D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; C013079:kalafungin; D000095622:Benzoisochromanequinones