S-D-lactoylglutathione in resting and activated human neutrophils.
Zymosan particles opsonised with human serum factors functionally activate human neutrophils and induce a substantial modification of the human neutrophil cytosolic glyoxalase system. The activity of glyoxalase I increases and the activity of glyoxalase II decreases by 20-40% of their resting cell activities during the initial 10 min of activation. The cellular concentration of the glyoxalase intermediate S-D-lactoylglutathione increases by ca. 100% of resting cell levels during this period. This modification may be related to the ability of S-D-lactoylglutathione to stimulate the assembly of microtubules.
D004789:Enzyme Activation; D005978:Glutathione / Q000031:analogs & derivatives* / Q000097:blood; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000378:metabolism; D008213:Lymphocyte Activation; D009504:Neutrophils / Q000378:metabolism*; D013869:Thiolester Hydrolases / Q000378:metabolism; D015054:Zymosan / Q000494:pharmacology; D000099301:Hydroxyacylglutathione Hydrolase
D005978:Glutathione; D007791:Lactoylglutathione Lyase; D013869:Thiolester Hydrolases; D015054:Zymosan; D000099301:Hydroxyacylglutathione Hydrolase; C013585:S-lactoylglutathione