[Distribution in the body and functional effects of fluorocarbons used as oxygen carriers].
After the infusion of perfluorochemicals (PFC) given as artificial blood gas carriers a temporary storage of the inert substances in tissues of the organism occurs. The time course of this effect was investigated in longitudinal studies in the rat and compared with changes of different organ functions, expressed as changes in the levels of serum enzymes, in the elimination of indocyanine green and in the duration of pentobarbital sleeping time which are dependent on the excretory and detoxifying functions of the liver. The intensity of the elimination of colloidal carbon was used as a measure of the activity of the reticulo endothelial system. Observation of the time course of these functional tests in comparison with the storage of PFC and changes in organ weight of liver and spleen showed that diminutions in function had a distinctly shorter duration than PFC storage, whereas the longest lasting effects were seen in organ weight increase is regarded as a compensatory effect that is associated without functional loss at the maximum of its appearance.
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D004796:Clinical Enzyme Tests; D005466:Fluorocarbons / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D007208:Indocyanine Green; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D008111:Liver Function Tests; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D013997:Time Factors; D014018:Tissue Distribution
D001802:Blood Substitutes; D005466:Fluorocarbons; C008807:perfluorotributylamine; C008805:perfluorodecalin; D007208:Indocyanine Green
Devenir dans l'organisme et influence fonctionnelle des fluorocarbures utilisés comme transporteurs d'oxygène.