[Effect of steroid aromatase inhibitors on the catecholamine content of the hypothalamus of neonatally androgenized rats].
Administration of 50 micrograms of testosterone propionate to newborn female rats on the 5th day of life provoked a reliable increase in noradrenaline and dopamine concentrations in the hypothalamus of 10-day-old rats. Neonatal administration of aromatase inhibitors on the 5th and 7th days of life prevented testosterone-induced increase in catecholamine concentrations. The data obtained prove the integration of the processes of testosterone aromatization and catecholamine accumulation in androgen-dependent brain differentiation.
D000733:Androstatrienes / Q000494:pharmacology; D000736:Androstenes / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D047072:Aromatase Inhibitors; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012727:Sex Characteristics; D013739:Testosterone / Q000494:pharmacology*
D000733:Androstatrienes; D000736:Androstenes; D047072:Aromatase Inhibitors; D002395:Catecholamines; C011658:androsta-1,4,6-triene-3,17-dione; D013739:Testosterone; C018213:androst-4-ene-3,6,17-trione; D004298:Dopamine; D009638:Norepinephrine
Vliianie ingibitorov aromatazy steroidov na soderzhanie katekholaminov v gipotalamuse neonatal'no androgenizirovannykh krys.