Denitrosation of N-nitrosodimethylamine and N-nitrosomethylurea by liver microsomes from trout (Salmo gairdneri Rich.).
N-Nitrosodimethylamine and N-nitrosomethylurea are partially metabolized to nitrite and formaldehyde by trout liver microsomes. Results show that the denitrosation pathway of both N-nitroso derivatives is NADPH-dependent, requires molecular oxygen, and is inhibited by common inhibitors of microsomal enzyme activities.
D000693:Anaerobiosis; D000818:Animals; D004128:Dimethylnitrosamine / Q000378:metabolism*; D008770:Methylnitrosourea / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D012487:Salmonidae / Q000378:metabolism*; D014337:Trout / Q000378:metabolism*
D008770:Methylnitrosourea; D004128:Dimethylnitrosamine