Comparison of effects of ingested medium- and long-chain triglyceride on gallbladder volume and release of cholecystokinin and other gut peptides.
In a double-blind, crossover study of the effect of ingested medium-chain triglyceride (MCT) and long-chain triglyceride (LCT) in six normal subjects, the gallbladder did not contract after ingestion of MCT but instead had significantly increased in volume at 2 hr after the meal. Plasma cholecystokinin (CCK) increased after the MCT meal, but gastrin, motilin, pancreatic polypeptide (PP), and GIP were unaffected. The long-chain triglyceride meal evoked a brisk and sustained gallbladder contraction, higher levels of CCK, and a significant increase in plasma PP and GIP levels.
D000328:Adult; D002766:Cholecystokinin / Q000378:metabolism*; D004311:Double-Blind Method; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology; D005260:Female; D005704:Gallbladder / Q000502:physiology*; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D006801:Humans; D008297:Male; D009119:Muscle Contraction; D010191:Pancreatic Polypeptide / Q000378:metabolism; D014280:Triglycerides / Q000494:pharmacology*
D005217:Fat Emulsions, Intravenous; D005768:Gastrointestinal Hormones; D014280:Triglycerides; D010191:Pancreatic Polypeptide; D002766:Cholecystokinin