Platelet factor 4 enhances fibrin fiber polymerization.
In order to further examine the role of platelet secretory products on fibrin assembly, we have examined the effects of purified platelet factor 4 (PF4) on fibrin formation in vitro. The kinetics of fibrin formation and the structural properties of the resulting fibrin gel are strongly affected by PF4. In the presence of 7.6 ng/mL PF4, the fibrin fiber mass-length ratio increases from 3.5 X 10(12) daltons/cm. These results emphasize the importance of the local microenvironment in clot structure and its subsequent fate at the site of vascular injury.
D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D009391:Nephelometry and Turbidimetry; D010978:Platelet Factor 4 / Q000502:physiology*; D011108:Polymers / Q000378:metabolism*; D013917:Thrombin / Q000494:pharmacology
D011108:Polymers; D010978:Platelet Factor 4; D005337:Fibrin; D005340:Fibrinogen; D013917:Thrombin