Evidence for a central muscarinic action by 1-(2-methyl-3-hydroxy-5-hydroxymethyl-4-pyridyl)-6,7-dihydroxy-1,2, 3,4-tetrahydroisoquinoline in regulating blood pressure in the anesthetized dog.
Anesthetized dogs injected with 1-(2-methyl-3-hydroxy-5-hydroxymethyl-4-pyridyl)-6,7-dihydroxy-1,2, 3,4-tetrahydroisoquinoline (PTIQ) into the common carotid artery, showed an immediate fall in blood pressure, whereas injection into the femoral vein produced a fall in blood pressure after a lapse of approximately 8 sec. Anesthetized dogs pretreated with atropine showed a decrease in mean blood pressure of 22% of control (PTIQ alone) after PTIQ was injected. In contrast, dogs pretreated with methylatropine showed a decrease of 41% of control after PTIQ was injected. Our data suggest that PTIQ may act centrally and peripherally by activation of muscarinic receptors.
D000758:Anesthesia; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002339:Carotid Arteries; D004285:Dogs; D005260:Female; D005268:Femoral Vein; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D011976:Receptors, Muscarinic / Q000187:drug effects*; D044005:Tetrahydroisoquinolines; D013764:Tetrahydronaphthalenes / Q000008:administration & dosage / Q000494:pharmacology*
D000959:Antihypertensive Agents; D009281:Naphthalenes; D011976:Receptors, Muscarinic; D044005:Tetrahydroisoquinolines; D013764:Tetrahydronaphthalenes; C046152:1-(2-methyl-3-hydroxy-5-hydroxymethyl-4-pyridyl)-6,7-dihydroxy-1,2-3,4-tetrahydroisoquinoline