title: Oncogenes and the pathogenesis of human cancers.
abstract: Proto-oncogenes are phylogenetically ancient genes which are involved in the normal controls of cell proliferation. Under some circumstances, these normal genes may be altered and generate qualitatively or quantitatively abnormal gene products. Under these circumstances the proto-oncogenes may be involved in the pathogenesis of malignant diseases.
mesh_terms: D005784:Gene Amplification; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics; D011519:Proto-Oncogenes; D014178:Translocation, Genetic