Effect of rifampin and its cyclopentyl analogue, MDL 473, on the expression of delayed type hypersensitivity to oxazolone.
The purpose of this study was to determine the effect of rifampin and its cyclopentyl analogue, MDL 473, on delayed type hypersensitivity (DTH) using a murine model. Neither compound has any significant effect on DTH (as measured by ear swelling) to oxazolone when administered i.p. to BALB/c mice at doses of 1, 10, 50 or 100 mg/kg beginning 3 days before oxazolone sensitization and continuing until hapten challenge 5 days later. In contrast, sex and age matched controls receiving 200 mg hydrocortisone/kg i.p. beginning on the day of oxazolone sensitization and continuing to hapten challenge demonstrate a significant (P less than 0.001) abrogation of DTH.
D000818:Animals; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000188:drug therapy* / Q000209:etiology; D051379:Mice; D008807:Mice, Inbred BALB C; D010081:Oxazolone / Q000276:immunology; D012293:Rifampin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D010081:Oxazolone; D012293:Rifampin; D006854:Hydrocortisone; C018421:rifapentine