[Age-related characteristics of the pharmacokinetics of acetylsalicylic acid].
Acetylsalicylic acid pharmacokinetics was studied in young, elderly and old patients after a single oral administration in a dose of 14 mg/kg. The pharmacokinetics data may be formalized by means of the one-compartment model with absorption. Constants of absorption and elimination, total clearance value are decreased with age. The half-life in elderly patients was 6.19 hrs, in old patients 12.2 hrs and in young patients 4.47 hrs. In elderly and old patients the area under the pharmacokinetic curve increased. The ability of serum proteins to bind salicylates reduced during ageing. The pharmacokinetic model was used for optimization of treatment with acetylsalicylic acid of elderly and old patients.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D001241:Aspirin / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D011485:Protein Binding; D012459:Salicylates / Q000378:metabolism; D020156:Salicylic Acid; D013997:Time Factors
D001798:Blood Proteins; D012459:Salicylates; D020156:Salicylic Acid; D001241:Aspirin
Vozrastnye osobennosti farmakokinetiki atsetilsalitsilovoĭ kisloty.