Pulmonary barotrauma in congenital diaphragmatic hernia: experimental study in lambs.
A left diaphragmatic hernia was created surgically in 20 fetal lambs between 93 and 110 days of gestation. Ten animals were alive with defects at cesarean section near term (135 to 140 days). These animals and two controls were submitted to various transpulmonary pressure gradients (inspiratory pressure minus pleural pressure). Hemodynamic and ventilatory studies were performed after the correction of the hernia. Morphometric analysis of the lung was carried out in all cases. The results showed a highly significant linear correlation between the transpulmonary pressure gradient employed and the pulmonary interstitial emphysema found at morphometry. Our data suggest that using low ventilatory pressures and not draining the pleural cavity results in less trauma to both lungs and may prevent one of the components of the pulmonary hypertension so often seen in newborns with congenital diaphragmatic hernia.
D000818:Animals; D001469:Barotrauma / Q000209:etiology*; D005260:Female; D006548:Hernia, Diaphragmatic / Q000628:therapy; D065630:Hernias, Diaphragmatic, Congenital; D008168:Lung / Q000503:physiopathology; D055370:Lung Injury; D011247:Pregnancy; D011312:Pressure; D012121:Respiration, Artificial / Q000009:adverse effects; D012756:Sheep