[In vitro and in vivo photochemical reactivity of quinine- and quinidine-N-oxide].
By irradiation with UV-light quinine- and quinidine-1,1'-dioxide in polar solvents are rearranged to 2'-oxo derivatives and in nonpolar solvents to formylindol derivatives. Rats being exposed to UV-light after oral administration of quinine- or quinidine-1,1'-dioxide showed in blood plasma the 2'-oxo derivates too. In accordance with the results of the different fotochemical reactivity of quinoline-1-oxide-, chlordiazepoxide, methaqualone-1-oxide and some pyrido-pyrimidine-8-oxides a first drafting is developed due to the supposed toxic effects of the exited imino-N-oxides.
D000818:Animals; D003497:Cyclic N-Oxides / Q000032:analysis*; D066298:In Vitro Techniques; D013058:Mass Spectrometry; D010777:Photochemistry; D011802:Quinidine / Q000031:analogs & derivatives* / Q000032:analysis; D011803:Quinine / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D003497:Cyclic N-Oxides; C045112:quinidine-N-oxide; D011803:Quinine; D011802:Quinidine
In-vitro- und in-vivo-Untersuchungen zur fotochemischen Reaktivität der Chinin- und Chinidin-N-Oxide.