Lymphoproliferative disorder of large granular lymphocytes: reversal of lymphocyte proliferation, anemia and neutropenia with chlorambucil.
A 54-year-old woman presented with hepatosplenomegaly, anemia, neutropenia and lymphocytosis. Most peripheral blood lymphocytes had the surface antigens T3+, Leu11+ and were morphologically large granular lymphocytes. Bone marrow presented 60% lymphoid infiltration. Treatment with chlorambucil produced complete reversal of hepatosplenomegaly, anemia, neutropenia and lymphocytosis, and reduction of marrow infiltration. The patient is well 12 months after discontinuation of therapy.
D000740:Anemia / Q000188:drug therapy / Q000209:etiology; D001853:Bone Marrow / Q000473:pathology; D002455:Cell Division; D002699:Chlorambucil / Q000008:administration & dosage / Q000627:therapeutic use*; D003613:Danazol / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000473:pathology*; D008232:Lymphoproliferative Disorders / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy / Q000209:etiology
D002699:Chlorambucil; D003613:Danazol