[Objectivation of the rheologic and hemodynamic and metabolic effects of ultraviolet irradiation of autologous venous blood in Fontaine type II-IV peripheral arterial occlusive disorders].
72 patients with disturbances of the peripheral arterial blood supply of type II to IV after Fontaine showed characteristic clinical, haemodynamic (first flow, peak flow occlusion-plethysmographically reduced) metabolic (paO2 and pvO2 decreased), plasmatic (fibrinogen and alpha 2-macroglobulin levels increased) and--as far as investigated (37 patients)--haemorheological changes (much increased apparent whole blood viscosity). The latter was found out above all in shear rates occurring in the microcirculation. Ultraviolet irradiation of venous autologous blood (1 ml/kg) during three weeks (nine times) leads the haemorheological and plasmatic parameters to normal levels and decisively improves the metabolic and haemodynamic parameters. This effect is still to be proved after six months, but only in a small extent after one or two years. Because of the weaker therapeutic effects of the common conservative treatment this therapy must be recommended.
D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000532:radiotherapy*; D001798:Blood Proteins / Q000378:metabolism; D001809:Blood Viscosity / Q000528:radiation effects; D005260:Female; D006439:Hemodynamics / Q000528:radiation effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D012212:Rheology; D014467:Ultraviolet Therapy
D001798:Blood Proteins; D010100:Oxygen
Objektivierung rheologisch-hämodynamischer und metabolischer Effekte der Ultraviolett-Bestrahlung venösen Eigenblutes bei peripheren arteriellen Durchblutungsstörungen vom Typ II-IV nach Fontaine.