title: [Iatrogenic bronchial obstruction: study of 4 atopic children with bronchial obstruction induced by acetyl salicylic acid].
abstract: The authors have studied the modification of the spirometric parameters in four atopic children, during nonallergic diet, after administration of ASA (400 mg). The examination of the respiratory functionality has showed a fall of parameters starting four hours after the challenge and with an increase of respiratory resistance. This bronchospastic reaction persisted for about eighteen hours to diminish 24 h. after administration of 400 mg of ASA. The study of spirometric values has showed a remarkable fall of MMEF, sign of small airways obstruction, but also of FEV1-CV for the involvement of the higher airways. The authors attribute the reaction to the metabolites of arachidonic acid (Leukotrienes) and to their different receptor site on the bronchial mucous membrane target cells. The authors conclude showing the gravity of injury that will induce imprudent administration of ASA in hypersensitive subject.
mesh_terms: D001241:Aspirin; D001249:Asthma / Q000175:diagnosis* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D002000:Bronchospirometry; D002648:Child; D002675:Child, Preschool; D006801:Humans
chemical_list: D001241:Aspirin
vernacular_title: Broncostruzione iatrogena: studio di 4 bambini atopici con broncostruzione scatenata da ASA.