title: Evaluation of the usefulness of a sensitive immunoradiometric assay for thyroid stimulating hormone as a first-line thyroid function test in an unselected patient population.
abstract: A new sensitive immunoradiometric assay for serum thyroid stimulating hormone (TSH) was applied to 1627 consecutive patients from four large clinics at Malmö General Hospital, in whom a thyroid function disorder was suspected. The final diagnoses were taken from the patients' charts at a follow-up 1-2 years after the primary evaluation. If only those patients without thyroid disease were used as a reference population, the 5th percentile was 0.8 mIU/l. When this cutoff limit was applied to the unselected patient population, the TSH assay had a high sensitivity for the diagnosis of hyperthyroidism (96%), a lower specificity (64%) and a very low predictive value (10%). Therefore, in the majority of the patients (72%) the sensitive TSH assay cannot be used alone to define thyroid function.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008297:Male; D008875:Middle Aged; D013959:Thyroid Diseases / Q000097:blood* / Q000175:diagnosis; D013960:Thyroid Function Tests / Q000379:methods*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine