title: Modification of the cysteamine side chain of thienamycin. II.
abstract: A new type of thienamycin derivatives (3a-3j, 4a, 4b), having a monothioacetal or a thioacetal side chain at the C-2 position was prepared, and the susceptibility to renal dehydropeptidase-1 (DHP-1) and the antimicrobial activity of these compounds were determined. The structure-activity relationships of these derivatives are also discussed.
mesh_terms: D001419:Bacteria / Q000187:drug effects; D003543:Cysteamine; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013845:Thienamycins / Q000138:chemical synthesis*
chemical_list: D007202:Indicators and Reagents; D013845:Thienamycins; D003543:Cysteamine