Experimental model for the study of the human appendix.
A simple and reproducible model for the experimental study of the normally functioning human appendix is described. The appendix removed from a human is transplanted into a nude mouse and is kept vital for at least 4 hours. This model is an improvement on previous models. It corresponds well with the working of the normal human appendix as regards tissue type and characteristics. Results are easily quantified and a paired control is possible in the experimental animal. This simplifies the experimental design and statistical calculations. The model can be used to gain additional information about the pathophysiology of the human appendix and the possible influence of drugs on this organ.
D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001065:Appendix / Q000098:blood supply / Q000502:physiology / Q000637:transplantation*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008866:Microsurgery / Q000379:methods*; D014183:Transplantation, Heterologous / Q000379:methods*; D014682:Vena Cava, Inferior / Q000601:surgery