Effect of hormones on seizure activity during pregnancy.
Increased seizure activity during pregnancy may result from two different effects: a dominant estrogenic effect early in pregnancy that directly affects the central nervous system lowering seizure threshold and a decrease of 50% or more in the plasma level of anticonvulsant drugs in some individuals late in pregnancy, resulting in loss of seizure control.
D004827:Epilepsy / Q000097:blood / Q000503:physiopathology*; D004958:Estradiol / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000503:physiopathology*; D011374:Progesterone / Q000097:blood
D012739:Gonadal Steroid Hormones; D011374:Progesterone; D004958:Estradiol