Spontaneous formation of an anti-S alloantibody in association with mixed connective tissue disease.
A spontaneous anti-S alloantibody developed without prior transfusion in a 33-year-old male with mixed connective tissue disease. It was detectable by indirect antiglobulin testing using anti-IgG specific, as well as polyspecific anti-human globulin. All previously reported naturally occurring anti-S antibodies had been cold reactive agglutinins, presumably IgMs.
D000328:Adult; D000941:Antigens / Q000097:blood / Q000276:immunology*; D019393:Arrestin; D005136:Eye Proteins / Q000097:blood / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000097:blood / Q000276:immunology*; D008297:Male; D008947:Mixed Connective Tissue Disease / Q000097:blood / Q000276:immunology*
D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins; D007518:Isoantibodies