title: [Antigen-specific and antigen-nonspecific reactions of the immunity system in vaccination with a purified concentrated staphylococcal anatoxin].
abstract: Immunization with purified and concentrated staphylococcal toxoid leads to the rapid 12-fold rise of the level of anti-alpha-toxin and to the 17-fold rise of the titres of antibodies to extracellular staphylococcal products. At the period of immunization phasic changes in cell-mediated and humoral immunity characteristics, indicative of the state of the nonspecific resistance system, can be observed. These changes consist in the transient suppression of phagocytosis, including a decrease in the activity of intraleukocytic bactericidal systems (myeloperoxidase and cation protein), a decrease in the activity of the complement and the bactericidal activity of the blood serum, which should be taken into account when using this immune preparation for therapy.
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D000942:Antigens, Bacterial / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007114:Immunization; D013203:Staphylococcal Infections / Q000276:immunology / Q000517:prevention & control; D013208:Staphylococcal Toxoid / Q000276:immunology* / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000276:immunology*; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D013208:Staphylococcal Toxoid
vernacular_title: Antigenspetsificheskie i antigennespetsificheskie reaktsii sistemy immuniteta pri vaktsinatsii ochishchennym kontsentrirovannym stafilokokkovym anatoksinom.