Pseudosarcomatous cystadenocarcinoma of the liver.
A case of papillary cystadenocarcinoma with spindle (pseudosarcomatous) metaplasia of the liver is described in a 64-year-old woman. This tumor was solitary, multiloculated, and had a fibrous pseudocapsule. It was composed of undifferentiated malignant epithelial cells, which lined cystic spaces, with sarcomatous cells underneath. Immunohistochemical studies showed no detectable alpha-fetoprotein in the tumor; keratin was present in epithelial and spindle tumor cells, and alpha 1-antitrypsin was present in cytoplasm of many tumor cells. Intracytoplasmic periodic acid--Schiff-positive, diastase-resistant globules, some of them reactive for alpha 1-antitrypsin, were seen. A primary liver tumor with this histology has not been described previously in the literature.
D003536:Cystadenocarcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D008875:Middle Aged; D012509:Sarcoma / Q000473:pathology*