Comparison of subacute toxicity of rubidomycine and its four derivatives.
In experiments carried out on Albino-Swiss mice we tried to compare some pharmacological properties of standard compound-rubidomycin with its 4 newly synthetized derivatives. DR-16 appeared to be more toxic compound than rubidomycin and DR-19 was found to possess the lowest toxicity.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000633:toxicity*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013329:Structure-Activity Relationship
D001798:Blood Proteins; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003630:Daunorubicin