Sodium-independent synaptosomal uptake of leucine.
The uptake of leucine by rat brain synaptosomes was investigated in a Na+-free medium. It was found that leucine was transported into synaptosomes by 2 uptake processes which were both extremely sensitive to inhibition by 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid. These 2 components were distinguishable from each other by kinetic analysis and by their relative sensitivity to inhibition by selected amino acids.
D000596:Amino Acids / Q000494:pharmacology; D000598:Amino Acids, Cyclic; D000818:Animals; D001921:Brain / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D007930:Leucine / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000494:pharmacology*; D013574:Synaptosomes / Q000378:metabolism*
D000596:Amino Acids; D000598:Amino Acids, Cyclic; C006504:2-aminobicyclo(2,2,1)heptane-2-carboxylic acid; D012964:Sodium; D007930:Leucine