Hypocholesterolemic action of 1-ethoxysilatrane.
Intraperitoneal administration of the organosilicon compound 1-ethoxysilatrane to the rat caused a 25% decrease in the concentration of cholesterol in serum without affecting that of triacylglycerols. The specific activity of 3-hydroxy-3-methylglutaryl CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis, was depressed in hepatic microsomes of silatrane-treated animals.
D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D017646:Organosilicon Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D012825:Silicon / Q000008:administration & dosage / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; D017646:Organosilicon Compounds; D014280:Triglycerides; C042292:1-ethoxysilatrane; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D012825:Silicon