Antipyrine disposition in calves. I. Effects of some drugs.
The influence of four drugs on antipyrine pharmacokinetic parameters was studied after 3 h, 2 and 6 days in 32 Friesian calves. Dexamethasone phosphate and griseofulvin led to increased antipyrine elimination. The effect of dexamethasone remained significant 2 and 6 days later. The rate of antipyrine elimination was markedly but transiently depressed by chloramphenicol and oxytetracycline. The apparent volume of antipyrine distribution remained unaltered during treatment.
D000818:Animals; D000983:Antipyrine / Q000378:metabolism*; D002417:Cattle / Q000378:metabolism*; D002701:Chloramphenicol / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D006118:Griseofulvin / Q000494:pharmacology; D006207:Half-Life; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D010118:Oxytetracycline / Q000494:pharmacology
D006118:Griseofulvin; D002701:Chloramphenicol; D003907:Dexamethasone; D000983:Antipyrine; D010118:Oxytetracycline