[Antihypoxic activity of cytochrome c heme peptides].
A comparative study of antihypoxic activity of five and two cytochrome c derivatives was performed during their single prophylactic administration on the model of acute hypobaric hypoxia (AHBH) and during rehabilitation period after AHBH, respectively. Antihypoxic efficiency of cytochrome c derivatives was shown to be dependent on doses, time of drug administration, and type of experimental animal resistance. The heme-nonapeptide of cytochrome c proved to be of maximum efficiency during prophylactic administration and rehabilitation period after AHBH.
D000208:Acute Disease; D000818:Animals; D004198:Disease Susceptibility; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D000860:Hypoxia / Q000188:drug therapy* / Q000517:prevention & control; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010544:Peroxidases / Q000627:therapeutic use*; D013997:Time Factors
D010544:Peroxidases; C021799:microperoxidase
Antigpoksicheskaia aktivnost' gem-peptidov tsitokhroma c.