title: The effect of segmental epidural analgesia on the neurobehavioural responses of newborn infants.
abstract: The effects of maternal segmental epidural analgesia on neonatal neurobehavioural responses were studied at the ages of 3 h, 1 day, 2 days and 4-5 days. Subjects were healthy, term neonates born vaginally to 14 mothers with an epidural block and to 15 mothers without analgesia. The only statistically significant differences were found at the age of 1 day, when the epidural group infants habituated and oriented better to inanimate auditory stimuli. It is concluded that segmental epidural analgesia with a low dose of bupivacaine can be regarded as being a safe obstetric analgesic method as regards neonatal behavioural responses.
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D002045:Bupivacaine / Q000008:administration & dosage / Q000494:pharmacology; D002652:Child Behavior / Q000187:drug effects*; D005260:Female; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology*; D009460:Neurologic Examination; D009949:Orientation / Q000187:drug effects; D011247:Pregnancy
chemical_list: D002045:Bupivacaine