[Biotransformation of the 14C-hydrogenated analog of phenazepam in inbred mice].
The elimination of 14C-hydrogenated analogue of phenazepam and its metabolites was studied in inbred C57B1/6 (B/6), BALB-c (C) and CBA mice. The kinetics of two-phase elimination of 14C-compounds with urine and feces was similar in all the above mouse strains. The excretion was realized mainly with feces, exceeding elimination with urine 5-6-fold in B6 mice and 10-11-fold in C and CBA mice. Some interstrain quantitative differences in metabolite composition were found. No metabolite was detected whose concentration would indicate a predominating direction of biotransformation of 14C-hydrogenated phenazepam analogue or distinguish it from other mouse strains. In the organism of mice, 14C-hydrogenated phenazepam analogue undergoes active aromatic hydroxylation and methoxylation via heterocycle (and possibly via chlorine-containing ring). At the same time dehydrogenation of 14C-hydrogenated phenazepam analogue molecule was not recorded.
D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000032:analysis / Q000378:metabolism*; D001711:Biotransformation; D002250:Carbon Radioisotopes; D005243:Feces / Q000032:analysis; D007700:Kinetics; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008815:Mice, Inbred Strains / Q000378:metabolism*; D010641:Phenotype; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D002250:Carbon Radioisotopes; D001569:Benzodiazepines; C017928:phenazepam; C052941:7-bromo-5-(2-chloro-6-hydroxyphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Biotransformatsiia 14C-gidrirovannogo analoga fenazepama v organizme mysheĭ inbrednykh liniĭ.