title: [The use of aminoglutethimide (orimeten) in disseminated breast cancer].
abstract: Administration of orimeten (aminoglutethimide), for disseminated breast cancer in 38 postmenopausal females, in whom other treatment modalities had failed, proved effective in 39%. Patients who had failed on tamoxifen responded to orimeten. Such side-effects as skin rash, drowsiness and cardiovascular disturbances were not pronounced. Limiting toxicity was 6%.
mesh_terms: D000328:Adult; D000616:Aminoglutethimide / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011960:Receptors, Estrogen / Q000187:drug effects
chemical_list: D011960:Receptors, Estrogen; D000616:Aminoglutethimide
vernacular_title: Primenenie aminogliutetimida (orimetena) pri disseminirovannom rake molochnoĭ zhelezy.