Dermal absorption of the antioxidant 4,4'-thiobis(6-tert-butyl-m-cresol) in Sencar mice and Fischer rats.
The dermal absorption of 14C-labeled 4,4'-thiobis(6-tert-butyl-m-cresol) (TBBC) was studied in female Sencar mice and male Fischer rats. Dermal application resulted in about 20% absorption in mice with more than 70% of the initial body burden (IBB) remaining on the treated skin site 3 days after treatment. In rats, less than 2% of a dermal dose was absorbed. This is in agreement with previous in vitro percutaneous absorption studies which have demonstrated that mouse skin is more permeable than rat skin to certain chemicals. Absorption did not increase linearly as the dose increased. Oral and i.v. exposures were conducted in the Sencar mice and compared to previously published rat oral and i.v. data. The disposition was similar between rats and mice after these routes of exposures, and the major route of elimination of absorbed TBBC was the feces in both species.
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism*; D001822:Body Burden; D003408:Cresols / Q000008:administration & dosage / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000032:analysis; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D051381:Rats; D011916:Rats, Inbred F344; D012869:Skin Absorption; D013045:Species Specificity
D000975:Antioxidants; D003408:Cresols; C040020:4,4'-thiobis(6-tert-butyl-3-cresol)