Allergy to laboratory animals: characterization and source of two major mouse allergens, Ag 1 and Ag 3.
Using quantitative immunoelectrophoretic methods, two major allergenic components, Ag 1 and Ag 3, have been identified in extracts of mouse dust. Both antigens were of similar electrophoretic mobility and molecular weight (20-25 kilodaltons). However, Ag 1 proved to be antigenically identical to mouse urinary prealbumin, whilst Ag 3 was shown immunohistochemically to be present within the hair follicle and on the stratum corneum.
D000485:Allergens / Q000276:immunology / Q000302:isolation & purification*; D000818:Animals; D000830:Animals, Laboratory / Q000276:immunology*; D004391:Dust / Q000032:analysis; D006197:Hair / Q000276:immunology; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D051379:Mice / Q000276:immunology*; D011228:Prealbumin / Q000276:immunology; D011852:Radioallergosorbent Test; D012867:Skin / Q000276:immunology; D012882:Skin Tests
D000485:Allergens; D004391:Dust; D011228:Prealbumin