Comparison of adjuvants for an inactivated infectious coryza vaccine.
Differently formulated inactivated infectious coryza vaccines were administered to 6-week-old chickens as a single dose of 10(8) colony-forming units of Haemophilus paragallinarum HP31. After 3 weeks, all chickens were challenged by intrasinus inoculation of HP31. Two vaccines, one containing an aluminum-hydroxide adjuvant and the other a combined aluminum-hydroxide + mineral-oil adjuvant, gave the best protection (means of 80% and 90%, respectively). Two vaccines that contained mineral oil as the sole adjuvant gave less protection (50% and 35%). The Quil A vaccine gave no significant protection. Granulomatous swellings developed at the site of injection in birds given mineral-oil adjuvant but not in those that received other adjuvants.
D000276:Adjuvants, Immunologic; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D002645:Chickens / Q000276:immunology*; D004655:Emulsions; D006192:Haemophilus Infections / Q000276:immunology / Q000662:veterinary*; D008899:Mineral Oil; D011201:Poultry Diseases / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000276:immunology / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000276:immunology
D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D004655:Emulsions; D014613:Vaccines, Attenuated; D008899:Mineral Oil