Unusual treatment response of a severe dystonia to diphenhydramine.
A 27-year-old man was admitted to the emergency department with a fluphenazine decanoate-induced dystonia. He was treated with 125 mg diphenhydramine IV in four doses and 2 mg benztropine IM. A fluctuating response was observed before continued remission of the dystonia. Possible reasons for variable patient responses to diphenhydramine are discussed.
D000328:Adult; D001590:Benztropine / Q000627:therapeutic use; D003692:Delayed-Action Preparations / Q000009:adverse effects; D004155:Diphenhydramine / Q000627:therapeutic use*; D004421:Dystonia / Q000139:chemically induced / Q000188:drug therapy*; D005476:Fluphenazine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy
D003692:Delayed-Action Preparations; D001590:Benztropine; D004155:Diphenhydramine; C011825:fluphenazine depot; D005476:Fluphenazine