[Mathematical model of stabilization of circadian rhythm in cell energy metabolism].
A mathematical model for circadian self-oscillation in the carbohydrate branch of energy metabolism (CEM) was analysed. The self-oscillations are due to the reciprocal regulation of the activities of 6-phosphofructokinase and fructose-1,6-bisphosphatase by fructose-1,6-bisphosphate. The circadian period was shown to be insensitive to metabolic disturbances because of the presence in CEM of negative feedback mechanisms regulating the activities of the key enzymes 6-phosphofructokinase, fructose-1,6-bisphosphatase, pyruvate kinase and phosphoenolpyruvate carboxykinase. It has been also shown that such mechanisms are largely synergistic in their action.
D000263:Adenylate Kinase / Q000378:metabolism; D002940:Circadian Rhythm; D004734:Energy Metabolism; D004789:Enzyme Activation; D005635:Fructosediphosphates / Q000378:metabolism; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological
D005635:Fructosediphosphates; D000263:Adenylate Kinase; C029063:fructose-1,6-diphosphate
Matematicheskaia model' stabilizatsii tsirkadnogo ritma v kletochnom énergeticheskom metabolizme.