[Radiomodifying effect of methandrostenolone on laryngeal cancer cells].
The property of methandrostenolone, a synthetic male hormone, as a stimulator of proliferative activity of tumour cells was studied in experimental analyses, conducted on the transplanted culture of HEP-2 cells and on xenografts of the human larynx cancer cultured in diffusive chambers. This property of the hormone was used to increase the sensitivity of human laryngeal tumour, to ionizing emission. The morphological study of histological specimens prepared from xenografts and histological specimens of patients with laryngeal tumour, who received preoperative distant gamma-therapy against a background of the methadrostenolone use, gave the results which allow recommending this hormone to be used during radiotherapy of patients with the laryngeal cancer.
D000328:Adult; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008297:Male; D008696:Methandrostenolone / Q000494:pharmacology*; D008875:Middle Aged; D009368:Neoplasm Transplantation; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D051381:Rats
D011838:Radiation-Sensitizing Agents; D008696:Methandrostenolone
Radiomodifitsiruiushchee deĭstvie metandrostenolona na kletki raka gortani.