Calcium-binding proteins in rat skin.
Skin Ca2+-binding protein (SCaBP) was reported to be distinct from the Ca2+-binding parvalbumin (PV), however, more recently its amino acid sequence was shown to be identical to PV. We purified a protein (Mr 12,000; pI4.5) from isolated epidermis (free of other cell layers) of adult rats and whole skin (containing no PV) of newborn rats. This protein is referred to as epidermal protein (EP-12), distinct from PV in its hydrophobicity, amino acid composition and immunological properties. Previously isolated SCaBP was shown to be a mixture of EP-12 and PV. The localization and possible functions of EP-12 and of PV in skin of adult and newborn rat are discussed.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000831:Animals, Newborn; D002135:Calcium-Binding Proteins / Q000302:isolation & purification* / Q000378:metabolism; D006651:Histocytochemistry; D007526:Isoelectric Point; D008297:Male; D008970:Molecular Weight; D051381:Rats; D012867:Skin / Q000378:metabolism*
D000596:Amino Acids; D002135:Calcium-Binding Proteins