Effect of Piracetam on electrocorticogram and local cerebral glucose utilization in the rat.
The effect of Piracetam on hypoxia-induced alterations of cerebral cortex electrogenesis is studied. The results showed protection. As this anti-hypoxidotic property could be linked to Piracetam influence on energy-metabolic processes in the brain, we studied the effect of this nootropic drug on local cerebral glucose utilization (LCGU) by means of a variant of the Sokoloff's technique. Our results showed that Piracetam enhances LCGU. We suggest that both effects, the functional and the metabolic one, are related.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology*; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D004569:Electroencephalography; D004734:Energy Metabolism / Q000187:drug effects; D000860:Hypoxia / Q000503:physiopathology* / Q000517:prevention & control; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology* / Q000627:therapeutic use; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D003837:Deoxy Sugars; D011760:Pyrrolidinones; D003847:Deoxyglucose; D010424:Pentobarbital; D010889:Piracetam