[The liver and aging. The effect of age on liver function and drug metabolism].
Theophylline (oxidative phase I metabolism) is biotransformed by the liver at an increasingly delayed rate with advancing age. Hymecromone (phase II metabolism) does not display any dependence of glucuronidisation on age. The indocyanine green half-life and the galactose elimination capacity show a highly significant dependence on age. Drugs with flow-limited elimination or mainly oxidative phase I biotransformation should be administered with reduced dosage level while monitoring the serum concentration levels. Drugs that are transformed via phase II reactions usually do not require dosage adjustment.
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D001711:Biotransformation; D005260:Female; D005693:Galactosemias / Q000097:blood; D006207:Half-Life; D006801:Humans; D006923:Hymecromone / Q000097:blood; D007208:Indocyanine Green / Q000097:blood; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D004364:Pharmaceutical Preparations / Q000097:blood*; D013806:Theophylline / Q000097:blood; D013997:Time Factors
D004364:Pharmaceutical Preparations; D006923:Hymecromone; D013806:Theophylline; D007208:Indocyanine Green
Leber und Alter. Einfluss des Lebensalters auf Leberfunktion und Arzneimittelmetabolismus.