title: Chemotherapeutic agents do not interact with neurotransmitter receptors.
abstract: The interactions of cisplatin, 5-fluorouracil, doxorubicin, mitomycin, carmustine (BCNU), cyclophosphamide, methotrexate and thio-TEPA were assessed at three neurotransmitter receptor binding sites. Each drug was inactive at concentrations as high as 10(-4) M in displacing the specific binding of 3H-spiperone to dopamine D2, 3H-pyrilamine to histamine H1, and 3H-quinuclidinyl benzilate to muscarinic cholinergic receptors. These data suggest that chemotherapy-induced nausea and vomiting are not due to interactions with neurotransmitter receptors.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D009325:Nausea / Q000209:etiology; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism*; D011968:Receptors, Histamine / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D011954:Receptors, Dopamine; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011976:Receptors, Muscarinic