[Effect of antioxidants and miscleron on destabilization of cell membranes during nephritis in children].
Effects of alpha-tocopherol, unithiol and mysclerone on lipid peroxidation, activity of phospholipases and the state of a body antioxidant systems were studied in 115 patients with glomerulonephritis. Administration of these drugs caused a decrease in the content of peroxides in blood and urine, a decrease in activity of endogenous phospholipases, an increase in the content of antioxidants as well as in the activity of antioxidant enzymes. Different effects of the preparations on various steps of lipid peroxidation as well as on the activity of phospholipases and antioxidant enzymes were shown.
D000293:Adolescent; D000975:Antioxidants / Q000627:therapeutic use*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D002994:Clofibrate / Q000627:therapeutic use*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D005921:Glomerulonephritis / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D009399:Nephrons / Q000187:drug effects / Q000378:metabolism; D014494:Unithiol / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
D000975:Antioxidants; D008054:Lipid Peroxides; D008563:Membrane Lipids; D014810:Vitamin E; D014494:Unithiol; D002994:Clofibrate
Vliianie antioksidantov i misklerona na protsessy destabilizatsii kletochnykh membran pri nefritakh u deteĭ.