Anti-myelin antibodies in cerebrospinal fluid and serum of patients with meningopolyneuritis Garin-Bujadoux-Bannwarth and other neurological diseases.
Anti-myelin antibodies (AMA) of IgG, IgM, and IgA class were investigated by ELISA in CSF and serum from patients with meningopolyneuritis Garin-Bujadoux-Bannwarth (GBB), other inflammatory diseases of the nervous system (ID) comprising meningoencephalitis (ME), multiple sclerosis (MS), and Guillain-Barré syndrome (GBS), and various noninflammatory neurological diseases (NID). Anti-Borrelia antibodies (ABA) were determined by ELISA in GBB patients. In CSF, a high incidence of IgG-AMA, IgM-AMA, and IgA-AMA was found in GBB as compared with ID and NID. On average, positive AMA titers were higher in GBB than in ID and NID, IgM-AMA titers in GBB being most prominent. In serum, AMA were found in all but 2 patients investigated. On average, IgM-AMA titers were higher in GBB and MS than in other diseases; IgG-AMA titers in GBB and ME were relatively low. Antibody indices, calculated from titer values and Ig concentrations in CSF and serum, indicate intrathecal synthesis mainly of IgG- and IgA-AMA, and of IgG- and IgM-ABA. Participation of AMA in the pathogenesis of GBB may be envisaged, but needs further confirmation.
D000907:Antibodies, Bacterial / Q000032:analysis / Q000096:biosynthesis; D001323:Autoantibodies / Q000032:analysis* / Q000134:cerebrospinal fluid; D001898:Borrelia / Q000276:immunology; D003711:Demyelinating Diseases / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D007075:Immunoglobulin M / Q000032:analysis / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D007136:Immunoglobulins / Q000032:analysis / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D008193:Lyme Disease / Q000150:complications* / Q000276:immunology; D008581:Meningitis / Q000150:complications / Q000276:immunology*; D008590:Meningoencephalitis / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology; D009186:Myelin Sheath / Q000276:immunology*; D009422:Nervous System Diseases / Q000276:immunology*; D011115:Polyneuropathies / Q000150:complications / Q000276:immunology*; D011129:Polyradiculoneuropathy / Q000276:immunology
D000907:Antibodies, Bacterial; D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins