title: The use of Markov chains to detect subtle variation in reproductive cycling.
abstract: Certain reproductive parameters in animals are particularly sensitive endpoints in toxicological experiments. Measured changes in one of these endpoints, estrous cycling in the rat, can reflect aberration in the underlying hormonal environment or end organ response. This article proposes the use of Markov chains to measure subtle changes in estrous cycling not readily detectable by standard methods of analysis.
mesh_terms: D000375:Aging; D000818:Animals; D001713:Biphenyl Compounds / Q000633:toxicity*; D004971:Estrus; D005260:Female; D008390:Markov Chains; D011336:Probability; D051381:Rats
chemical_list: D001713:Biphenyl Compounds