Antibody isotype produced by pregnant mice immunised with fetal allogeneic lymphocytes is mainly IgG1.
Virgin and Pregnant BALB/c mice were immunized three times with (BALB/c X CBA)F1 fetal or adult lymphocytes. An enzyme linked immunosorbent assay (ELISA) was developed for analysing the isotypes and specificities of the alloantibody produced. Pregnant mice immunized with fetal lymphocytes showed an immunodeviation towards IgG1 production compared with other groups.
D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis; D007518:Isoantibodies / Q000276:immunology*; D007519:Isoantigens / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011270:Pregnancy, Animal
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007518:Isoantibodies; D007519:Isoantigens