Peripheral nerve fibres regenerate through myenteric plexus.
The ability of myenteric glia and neurons to support peripheral nerve regeneration was tested by grafting pieces of muscularis externa 5 mm long from the distal colon of inbred CBA mice adjacent to the proximal stump of cut common peroneal nerves. By two weeks after operation many axons had invaded the plexus and after 3 weeks regeneration common peroneal nerve fibres could be identified in all parts of the plexus throughout the grafts. Some axonal profiles within the plexus appeared to be in the early stages of myelination by enteric glia. Axons surrounded by compact myelin were found at the periphery of ganglia, but the cells involved resembled Schwann cells and could not be positively identified as enteric glia. Profiles similar to those of regenerating axons were only very rarely seen in control experiments in which grafts were placed adjacent to intact common peroneal nerves. It is suggested that the cellular elements of the myenteric plexus can support peripheral nerve regeneration.
D000818:Animals; D003106:Colon / Q000294:innervation; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008854:Microscopy, Electron; D009197:Myenteric Plexus / Q000502:physiology* / Q000637:transplantation; D009416:Nerve Regeneration; D010525:Peripheral Nerves / Q000502:physiology* / Q000648:ultrastructure