[Effect of sodium selenite, vitamin E and retabolil alone and in combination on certain parameters of protein metabolism in experimentally hypotrophic rats of different ages].
Two types of hypotrophy (complete starvation and aurantin administration) were simulated in experimental rats. Significant changes were revealed in certain parameters of protein metabolism (decreased content of total protein, RNA and DNA in the blood, liver and skeletal muscles, dysproteinemia) leading to the drop in the mass of the body and internal organs of the test animals. The degree of these disorders expression was studied in relation to the hypotrophy genesis and the animals age. It was shown that the shift in the protein metabolism taking place in hypotrophy could be corrected with the use of sodium selenite, vitamin E, retabolil and their varying combinations.
D000818:Animals; D001835:Body Weight; D004359:Drug Therapy, Combination; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077603:Nandrolone Decanoate; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D020887:Selenious Acid; D012643:Selenium / Q000008:administration & dosage / Q000627:therapeutic use*; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*
D011506:Proteins; D014810:Vitamin E; D009277:Nandrolone; D020887:Selenious Acid; D000077603:Nandrolone Decanoate; D012643:Selenium
Vliianie selenita natriia, vitamina E, retabolila i ikh kombinatsiĭ na nekotorye pokazateli belkovogo obmena krys raznogo vozrasta pri éksperimental'noĭ gipotrofii.