Specificity of ethylcholine mustard aziridinium as an irreversible inhibitor of choline transport in cholinergic and noncholinergic tissue.
The sensitivity of choline transport to inhibition by ethylcholine mustard aziridinium (ECMA) was studied in several tissues. Choline transport was found to be inhibited irreversibly by ECMA in guinea pig and rat synaptosomes but not inhibited in erythrocytes or kidney slices. If this finding can be extended to other tissues ECMA sensitivity may provide a simple criterion for identifying the choline carrier associated with cholinergic tissue.
D000818:Animals; D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D002794:Choline / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects; D006168:Guinea Pigs; D006801:Humans; D007668:Kidney / Q000187:drug effects; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism
D001388:Aziridines; D001389:Azirines; C044894:ethylcholine aziridinium; D002794:Choline