title: [Protein metabolism and lipid balance in dietary treatment of acute enteritis in infants with a defined standardized oligopeptide diet].
abstract: The advantage of a standardized oligopeptide formula (Peptisorb päd) for dietary management of diarrhea was proved in 10 infants aged 1 to 10 months with body weights between 4000 and 8860 g. The nitrogen balance turned to normal already at day 3 to 4 of the treatment due to the rapid increase of food supply. Whole body protein parameters estimated by 15N yeast protein thermitase hydrolyzate as a tracer substance were already normalized at that time. Protein synthesis amounted to 5.0 +/- 1.5 g/kg/day, protein breakdown to 3.7 +/- 1.5 g/kg/day and net protein gain to 1.3 +/- 0.6 g/kg/day, resp. Reutilisation rate of endogenous nitrogen was found to be 83%. This correlates with the relatively high nitrogen supply of the oligopeptide diet in comparison to mother's milk feeding. Approximately 15% of the administered amount of total nitrogen were excreted in the feces in contrast to only 5.8% of the 15N tracer dose, indicating the higher losses of endogenous nitrogen due to enteritis. The absorption of the medium chain triglycerides from the diet was 97.5% at an average and thus extremely high.
mesh_terms: D000208:Acute Disease; D003968:Diarrhea, Infantile / Q000178:diet therapy* / Q000378:metabolism; D004751:Enteritis / Q000178:diet therapy* / Q000378:metabolism; D006801:Humans; D007223:Infant; D050356:Lipid Metabolism; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D009842:Oligopeptides / Q000008:administration & dosage*; D011506:Proteins / Q000378:metabolism*
chemical_list: D009842:Oligopeptides; D011506:Proteins; D009584:Nitrogen
vernacular_title: Eiweissstoffwechsel- und Fettbilanzen unter diätetischer Behandlung der akuten Säuglingsenteritis mit einer definierten, standardisierten Oligopeptid-Nahrung.