Permanent neurological sequelae due to lithium toxicity.
Lithium intoxication is well known to produce acute and chronic symptoms but development of permanent neurological deficit is a rarity. Six cases of manic depressive psychosis who developed neurological sequelae following treatment with lithium carbonate are described. There were multiple lesions in the central nervous system. However, the main brunt was borne by cerebellum. The serum lithium levels of five patients were within therapeutic range. The value of identifying the precipitating factors, early diagnosis and prompt intervention in the prevention of persistent neurological dysfunction is emphasized.
D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy; D002531:Cerebellum / Q000000981:diagnostic imaging; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008094:Lithium / Q000506:poisoning* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology; D009431:Neural Conduction; D011859:Radiography
D008094:Lithium