[The effect of ion pair formation on the pharmacokinetic properties of drugs. 1. The effect of alpha-methylpalmitic acid on the pharmacokinetics of quinine in rabbits].
The transport of quinine through artificial lipid membranes is significantly increased by use of alpha-methylpalmitinic acid (alpha-MPS). Using rabbits it could be shown that the alpha-MPS causes a significant increase of the mean resistance time (MRT) of quinine. Besides the alpha-MPS causes an increases Cmax and a shorter tmax of the quinine blood levels.
D000818:Animals; D002626:Chemistry, Pharmaceutical; D007700:Kinetics; D008567:Membranes, Artificial; D010169:Palmitic Acids / Q000032:analysis*; D010539:Permeability; D011803:Quinine / Q000097:blood / Q000378:metabolism*; D011817:Rabbits
D008567:Membranes, Artificial; D010169:Palmitic Acids; C034839:2-methylhexadecanoic acid; D011803:Quinine
Einfluss der lonenpaarbildung auf die pharmakokinetischen Eigenschaften von Arzneistoffen. 1. Mitteilung: Einfluss von alpha-Methylpalmitinsäure auf die Pharmakokinetik von Chinin am Kaninchen.