title: Valorization of rapeseed meal. 3. Effects of glucosinolate content on food intake, weight gain, liver weight and plasma thyroid hormone levels in growing rats.
abstract: Seven groups of 10 growing rats each were fed a control diet or rapeseed diets with glucosinolate contents ranging from 4.4 to 36.6 mM/kg DM. After a 5-day adaptation period, the rats were fed ad libitum for 17 days. The food intake of the experimental groups was maximal after 11 days and was, on an average, 4 to 45% lower than that of the control group. The differences were still greater during the last 7 days. Daily weight gain was also maximal after 8 days and began to decrease, dropping to 1 g during the last days. There were negative curvilinear relationships between food intake or weight gain and diet glucosinolate content. Liver weight (g/100 g of body weight) was not significantly altered by glucosinolate intakes between 0.08 and 0.39 mM/day. However, in the groups fed the diets with the lowest glucosinolate contents, plasma triiodothyronine (T3) and thyroxine (T4) levels were 50% lower than in the control group and 70 or 80% lower, respectively, with the diets having the highest glucosinolate contents.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D001937:Brassica; D004435:Eating / Q000187:drug effects*; D005961:Glucosinolates / Q000494:pharmacology*; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013865:Thioglycosides / Q000494:pharmacology*; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D005961:Glucosinolates; D013865:Thioglycosides; D013963:Thyroid Hormones; D014284:Triiodothyronine; D013974:Thyroxine