title: Developmental expression of prion protein gene in brain.
abstract: Synthesis of the cellular isoform of the prion protein (PrPC) was found to be regulated during development of the hamster brain. PrP poly A(+) RNA was readily detectable 10 days postpartum; after 20 days of age, no change in its level could be detected through 13 months of age. Low levels of PrP poly A(+) RNA were detectable 1 day after birth. By contrast, myelin basic protein poly A(+) RNA was found at high levels in brain at 30 days of age and thereafter declined steadily. Using monospecific PrP antisera, immunoprecipitable cell-free translation products were detected at low levels 2 days after birth and increased progressively through 10 days of age. How the levels of PrP mRNA participate in brain development and function remains to be established.
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development / Q000502:physiology*; D006224:Cricetinae; D005786:Gene Expression Regulation; D011328:Prions; D012333:RNA, Messenger / Q000235:genetics; D012795:Sialoglycoproteins / Q000235:genetics*
chemical_list: D011328:Prions; D012333:RNA, Messenger; D012795:Sialoglycoproteins