Concentrations of ciprofloxacin in human liver, gallbladder, and bile after oral administration.
We have measured concentrations of ciprofloxacin in serum, hepatic tissue, gallbladder, and bile in 10 patients after a single oral dose of 750 mg given before cholecystectomy. Mean liver and gallbladder tissue concentrations were 12.76 micrograms X g-1 +/- 2.79 (SEM) and 5.94 micrograms X g-1 +/- 1.35, respectively. Concentrations in bile taken from the gallbladder (7 patients) ranged from 68 to 225 micrograms X ml-1, with a mean bile/serum concentration ratio of 49. Concentrations in bile taken from the common bile duct (2 patients) were 17 and 16 micrograms X ml-1.
D000284:Administration, Oral; D000368:Aged; D001646:Bile / Q000378:metabolism*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005704:Gallbladder / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D002939:Ciprofloxacin