Role of vitamin B12 and folate deficiencies in carcinogenesis.
A significant body of experimental evidence supports the notion that a deficiency of either vitamin B12 or folic acid enhances the activity of various carcinogens. Unifying mechanisms are proposed to explain this cocarcinogenic role.
D000818:Animals; D002273:Carcinogens; D004032:Diet; D005492:Folic Acid / Q000378:metabolism; D005494:Folic Acid Deficiency / Q000150:complications*; D006801:Humans; D008715:Methionine / Q000378:metabolism; D009369:Neoplasms / Q000209:etiology*; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000473:pathology; D014806:Vitamin B 12 Deficiency / Q000150:complications*
D002273:Carcinogens; D005492:Folic Acid; D008715:Methionine