Treatment of relapsing Clostridium difficile diarrhoea by administration of a non-toxigenic strain.
Two patients with relapsing Clostridium difficile diarrhoea following metronidazole and vancomycin therapy were colonised with a non-toxigenic avirulent Clostridium difficile strain given orally in three doses. Both patients appeared to respond without side-effects. Oral bacteriotherapy with a defined nontoxigenic strain of Clostridium difficile would appear to represent an acceptable, alternative and novel way to treat hospitalised patients who relapse with Clostridium difficile diarrhoea after specific antibiotic therapy.
D000368:Aged; D000369:Aged, 80 and over; D003013:Clostridium / Q000254:growth & development*; D003967:Diarrhea / Q000628:therapy; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology / Q000628:therapy*; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000009:adverse effects; D012008:Recurrence; D014640:Vancomycin / Q000009:adverse effects
D008795:Metronidazole; D014640:Vancomycin