Acute trimethyltin limbic-cerebellar syndrome.
An acute limbic-cerebellar syndrome was seen in six industrial workers who inhaled trimethyltin (TMT). Clinical features included hearing loss, disorientation, confabulation, amnesia, aggressiveness, hyperphagia, disturbed sexual behavior, complex partial and tonic-clonic seizures, nystagmus, ataxia, and mild sensory neuropathy. Severity paralleled maximal urinary organotin levels. One patient died and two remained seriously disabled.
D000208:Acute Disease; D000328:Adult; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology; D002526:Cerebellar Diseases / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008032:Limbic System / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D014220:Trialkyltin Compounds / Q000009:adverse effects*; D014298:Trimethyltin Compounds / Q000009:adverse effects*
D014220:Trialkyltin Compounds; D014298:Trimethyltin Compounds; C046488:trimethyltin