[Effect of vinblastine on the proliferative and immune responses of the lymphoid cells of the draining lymph node and spleen in mice undergoing regional immunization with ram erythrocytes].
It was found that vinblastine administered 48 hours after immunization of mice by sheep red cells produced a long-term (for up to 3 days) suppression of 3H-thymidine inclusion into lymphoid cells following a 8-12-hour latent period. This was accompanied with a complete elimination of humoral response of the draining lymph node and a five-fold decrease of the number of antibody-forming cells in the spleen.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004912:Erythrocytes / Q000276:immunology*; D007108:Immune Tolerance / Q000187:drug effects; D007114:Immunization / Q000379:methods*; D008198:Lymph Nodes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D013997:Time Factors; D014747:Vinblastine / Q000494:pharmacology*
D014747:Vinblastine
Vliianie vinblastina na proliferativnyĭ i immunnyĭ otvet limfoidnykh kletok dreniruiushchego limfaticheskogo uzla i selezenki mysheĭ pri regionarnoĭ immunizatsii éritrotsitami barana.