Cerebral glycogenolysis and glycolysis in malathion-treated hyperglycaemic animals.
Treatment with malathion resulted in an increase in the level of blood glucose and lactate and reduced cerebral glycogen, 2 hr after its administration. The blood pyruvate level was not changed. The activities of glycogenolytic enzymes (glycogen phosphorylase and phosphoglucomutase) were increased significantly in the brain, whereas that of glucose-6-phosphatase remained unchanged. The activity of the glycolytic enzyme-hexokinase was increased significantly in malathion-treated animals, whereas those of the glucose-6-phosphate and lactate dehydrogenases were not significantly changed. The changes in enzyme activities may be a compensatory mechanism to provide energy in the form of glucose to cerebral tissue on account of stimulatory effects in malathion-treated animals.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006003:Glycogen / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects*; D006943:Hyperglycemia / Q000139:chemically induced* / Q000378:metabolism; D007773:Lactates / Q000097:blood; D008294:Malathion / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood; D051381:Rats
D001786:Blood Glucose; D007773:Lactates; D011773:Pyruvates; D006003:Glycogen; D008294:Malathion