Plasma enkephalin-like peptide response to chronic nicotine infusion in guinea pig.
Nicotine administration, using mini-osmotic pumps, to male guinea pigs (31 micrograms/h for 10 days) resulted in a significant elevation of plasma epinephrine and enkephalin-like peptides but not norepinephrine. The increase in plasma epinephrine and enkephalin-like peptides was not accompanied by corresponding alterations in either adrenal medullary synthesis or blood pressure and heart rate. These findings may provide a partial explanation for the observation that chronic smoking does not induce hypertension.
D000313:Adrenal Medulla / Q000187:drug effects*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004745:Enkephalins / Q000097:blood*; D004837:Epinephrine / Q000378:metabolism*; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D008297:Male; D009538:Nicotine / Q000494:pharmacology* / Q000633:toxicity; D013268:Stimulation, Chemical
D004745:Enkephalins; D009538:Nicotine; D004837:Epinephrine