Endoscopic sphincter of Oddi manometry in healthy volunteers.
This study evaluates the endoscopic manometric findings within the sphincter of Oddi (SO) in nine healthy volunteers premedicated with atropine 1 h before and with diazepam during the investigation. We measured the bile duct sphincter in seven persons and the pancreatic duct sphincter in two. A hydraulic capillary infusion system and a triple-lumen catheter were used. In all the SO was identified as a zone (median length, 8 mm) with elevated base-line pressure and superimposed phasic activity. Median values for amplitude was 102.9 mm Hg; base-line pressure, 10 mm Hg; wave duration, 4.8 sec; and frequency, 2.6/min. Most waves propagated antegrade or simultaneously, and in no individual were more than one third of the waves retrograde. When peak-to-peak intervals were analyzed in one volunteer with prolonged manometry, a basal mode of 6 sec or an even multiple of this value was disclosed, indicating that the SO is paced.
D000293:Adolescent; D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000502:physiology*; D004724:Endoscopy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods; D008875:Middle Aged; D012016:Reference Values; D009803:Sphincter of Oddi / Q000502:physiology*