title: Intratumoral doxycycline for skin metastases of human malignancies.
abstract: As soon as its inducibility of lethality via prompt deprivation of heavy metals and HDL-cholesterol was born out, an intratumoral administration of doxycycline, an anti-prokaryotic agent, was undertaken in 7 patients presenting with skin metastases from a variety of malignancies. Complete remission of these lesions was attained in 6. The histological observation of elongated areas of acellularity along with central vessels appeared to suggest doxycycline-mediated cellular disintegration, resulting in empty tumor cords. Specific tumor selectivity of the treatment can be sustained by the intra- and/or peri-tumoral confinement of the agent. The technique may constitute a novel mode of cancer cell elimination.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D004318:Doxycycline / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007271:Injections, Intradermal; D008297:Male; D008875:Middle Aged; D051381:Rats; D012878:Skin Neoplasms / Q000188:drug therapy / Q000556:secondary*
chemical_list: D004318:Doxycycline