Human pharmacology of 5-epi-sisomicin (Sch 22591) following intramuscular administration.
5-epi-sisomicin was given as a single intramuscular injection of 1 mg/kg to six healthy male adults. Serum peak concentrations averaged 3.07 mg/l, the mean elimination half life was 179 min and the mean 24 h urinary recovery was 85.3%. Local and systemic tolerance was good.
D000328:Adult; D006207:Half-Life; D006801:Humans; D007273:Injections, Intramuscular; D007700:Kinetics; D008297:Male; D012853:Sisomicin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism
C015852:pentisomicin; D012853:Sisomicin