[Gliotrophic effect of the total peptide fraction isolated from the urine of healthy subjects and patients with manic-depressive psychosis].
The authors studied the effect of the total peptide fraction of the urine of healthy donors and patients with manic-depressive psychosis on the development of glioneuronal aggregates of the cerebral cortex cultivated in collagen gel. Urine peptides from the patients dramatically increased the migration and differentiation of glioblasts while the action of healthy donors' peptides was less marked. The growth of neurites under the effect of peptides significantly differed from the control values.
D000818:Animals; D001714:Bipolar Disorder / Q000652:urine*; D002454:Cell Differentiation / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000187:drug effects*; D004622:Embryo, Mammalian; D006133:Growth Substances / Q000652:urine*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D009457:Neuroglia / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology / Q000652:urine*
D006133:Growth Substances; D010455:Peptides
Gliotroficheskoe vliianie summarnoĭ peptidnoĭ fraktsii, vydelennoĭ iz mochi zdorovykh liudeĭ i bol'nykh maniakal'no-depressivnym psikhozom.