Tolerance to orally induced anaphylactic sensitisation to cow's milk proteins and patency of the intestinal mucosa in the neonatal guinea pig.
Guinea pigs fed cow's milk within 2 days of birth may acquire tolerance to anaphylactic sensitisation to cow's milk proteins. Appreciable amounts of beta-lactoglobulin may be detected in their blood, in contrast with animals receiving cow's milk later than this age. Uptake of beta-lactoglobulin from the gut to circulation ceases after the 6th postnatal day. These findings could be relevant to cot death in the human infant should the anaphylactic hypothesis be substantiated.
D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D002417:Cattle; D006168:Guinea Pigs; D007108:Immune Tolerance; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000276:immunology / Q000473:pathology; D007782:Lactoglobulins / Q000378:metabolism; D008894:Milk Proteins / Q000276:immunology*; D010323:Passive Cutaneous Anaphylaxis
D007782:Lactoglobulins; D008894:Milk Proteins