Noninvasive delivery of a novel inotropic catecholamine: iontophoretic versus intravenous infusion in dogs.
Using a newly developed iontophoretic delivery device, a novel inotropic catecholamine, pharmacologically similar to dobutamine, has been successfully administered to dogs by noninvasive transdermal infusion for periods of up to 1.5 h. The technique was compared with intravenous infusion and shown to be capable of achieving the same degree of cardiac contractility and steady-state plasma concentrations of the inotrope. There was also a good linear relationship between the applied current and the resulting steady-state plasma concentrations of the inotrope. Approximately 2 mA of applied current during transdermal iontophoresis produced a response equivalent to an intravenous infusion of 1 micrograms/kg/min of the drug.
D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage* / Q000097:blood; D004280:Dobutamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood; D004285:Dogs; D007262:Infusions, Intravenous; D007478:Iontophoresis; D009200:Myocardial Contraction / Q000187:drug effects
D002316:Cardiotonic Agents; D004280:Dobutamine; C046155:4-(2-((3-(3-benzenecarboxamide)-1-methylpropyl)amino)ethyl)-1,2-benzenediol