An unusual case of POEMS syndrome.
A 58-year-old woman presented with a history of premature onset of menopause, longstanding hepatosplenomegaly, monoclonal gammopathy, lower limb polyneuropathy of recent onset, diabetes mellitus, excessive perspiration and leg edema. Polyneuropathy and excessive perspiration improved following a course of prednisone and melphalan. The clinical and pathophysiological features fit the rare entity known as POEMS syndrome.
D004359:Drug Therapy, Combination; D005260:Female; D006529:Hepatomegaly / Q000150:complications*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007074:Immunoglobulin G; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications*; D011115:Polyneuropathies / Q000150:complications* / Q000188:drug therapy; D011241:Prednisone / Q000008:administration & dosage; D013577:Syndrome
D007074:Immunoglobulin G; D008558:Melphalan; D011241:Prednisone