Carbachol-induced EEG 'theta' activity in hippocampal brain slices.
Application of the cholinergic agonist carbachol (50 microM) produced theta-like rhythmical waveforms, recorded in the stratum moleculare of the dentate gyrus. Atropine sulfate (50 microM) antagonized the carbachol-induced theta-like activity, consistent with this action of atropine in vivo. These results provide the first direct evidence that hippocampal neurons are capable of producing synchronized slow-wave activity when isolated from pulsed rhythmic inputs of the medial septum and other brain regions.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001683:Biological Clocks; D002217:Carbachol / Q000494:pharmacology*; D002799:Cholinergic Fibers / Q000502:physiology; D004569:Electroencephalography; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D009434:Neural Pathways / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012688:Septum Pellucidum / Q000502:physiology; D013826:Theta Rhythm
D001285:Atropine; D002217:Carbachol