title: Cytoplasmic creatine kinase in normal and pathological human kidney tissue.
abstract: Cytoplasmic creatine kinase (CK) activity was measured in 39 renal cortex samples from various kidney diseases. The highest CK values were observed in normal tissues (507 +/- 71). The mean values of CK enzymatic activity in the other groups decreased in the following order: chronic pyelonephritis (273 +/- 98), hydronephrosis (233 +/- 102), renal tuberculosis (133 +/- 34), pyonephrosis (96 +/- 46), and hypernephroma (45 +/- 33). The decrease in CK activity in kidney tissue paralleled tissue damage, and affects cellular functionality in relation with the processes that use adenosine 5'-triphosphate, such as the ionic pumps.
mesh_terms: D002292:Carcinoma, Renal Cell / Q000201:enzymology; D002908:Chronic Disease; D003402:Creatine Kinase / Q000378:metabolism*; D003593:Cytoplasm / Q000201:enzymology; D006801:Humans; D006869:Hydronephrosis / Q000201:enzymology; D007527:Isoenzymes; D007668:Kidney / Q000201:enzymology*; D007674:Kidney Diseases / Q000201:enzymology*; D007680:Kidney Neoplasms / Q000201:enzymology; D011704:Pyelonephritis / Q000201:enzymology; D014398:Tuberculosis, Renal / Q000201:enzymology
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase