Regulation of insulin-receptor mRNA levels by glucocorticoids.
We found with IM-9 human cultured lymphocytes, that the glucocorticoid dexamethasone increased insulin-receptor mRNA levels. This increase correlated in a time- and dose-dependent manner with the increase in the biosynthesis of the insulin-receptor precursor. In addition, in AR42J cultured rat pancreatic acinar cells, dexamethasone increased insulin-receptor mRNA levels. These studies suggest, therefore, that an increase in mRNA levels is an early step in the regulation of the insulin receptor by glucocorticoids in several cell types.
D003907:Dexamethasone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000032:analysis*; D011972:Receptor, Insulin / Q000235:genetics*
D012333:RNA, Messenger; D003907:Dexamethasone; D011972:Receptor, Insulin