Structure-function relationships in radiation-induced cell and tissue lesions: special references to the contributions of scanning electron microscopy and hematopoietic tissue responses.
Contributions of scanning electron microscopy to the field of radiation biology are briefly reviewed and presented in terms of an overall goal to identify and characterize the structural features of radiation-induced lesions in vital cell and tissue targets. In the context of "lesion" production, the major radiation-elicited response sequences, the types and nature of measured end points, and governing temporal and radiobiological parameters are discussed and illustrated by using results derived from both in vitro cell systems and in vivo studies that measured tissue responses from various organ systems (respiratory, digestive, circulatory, and central nervous systems). Work in our laboratory on the nature of early and late hematopathologic tissue responses (aplastic anemia and myeloid leukemia) induced by protracted radiation exposure and the "bridging effect" of repair processes relative to the expression of these pathologies is highlighted.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000528:radiation effects* / Q000648:ultrastructure; D006801:Humans; D007421:Intestine, Small / Q000528:radiation effects / Q000648:ultrastructure; D007953:Leukemia, Radiation-Induced / Q000473:pathology; D008214:Lymphocytes / Q000528:radiation effects / Q000648:ultrastructure; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011832:Radiation Injuries / Q000473:pathology; D011833:Radiation Injuries, Experimental / Q000473:pathology