[Enhancement of the effect of radiotherapy of Guerin's carcinoma by tinidazole].
Tinidazol, an electron-acceptor compound, was studied for its influence on the effectiveness of radiation treatment of Guerin's carcinoma. It was shown in terms of tumour regression, percentage of inhibition, time of tumour volume doubling, rate of the tumour growth renewal and average survival that in the presence of tinidazol, the antitumour effectiveness of radiation treatment is 1.6-2.0 times as high as radiation alone. Morphologic studies confirm the ability of tinidazol to enhance the radiation damage.
D000818:Animals; D009374:Neoplasms, Experimental / Q000473:pathology / Q000532:radiotherapy*; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D051381:Rats; D014011:Tinidazole / Q000627:therapeutic use*
D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; D014011:Tinidazole
Usilenie luchevogo vozdeĭstviia na kartsinomu Gerena s pomoshch'iu tinidazola.