Age-related hearing loss in BDF1 mice as evidenced by the brainstem auditory evoked potential.
Age-related hearing loss was studied in unanesthetized female BDF1 mice using brainstem auditory evoked potential (BAEP) latency-intensity (L-I) profiles and BAEP thresholds. The mice were divided into 5 age-related groups: 3-4 months, 5.5-7 months, 9-10 months, 12 months and 18 months. Relative to the youngest group, BAEP threshold data indicated shifts in auditory sensitivity ranging from +6 dB for the 5.5- to 7-month-old group to +71 dB for the 18-month-old group. The BAEP L-I profiles of older mice were consistent with recruitment-type sensorineural (cochlear) hearing losses. No evidence of retrocochlear involvement was observed.
D000375:Aging; D000818:Animals; D001300:Audiometry, Evoked Response; D001306:Auditory Pathways / Q000503:physiopathology; D001309:Auditory Threshold; D001933:Brain Stem / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology*; D006801:Humans; D006824:Hybridization, Genetic; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D011304:Presbycusis / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology