Recurrent stroke associated with thymoma and anticardiolipin antibodies.
A 44-year-old woman developed recurrent thrombotic cerebral cortical infarctions. IgG and IgM anticardiolipin antibodies were found, as was a thymoma. To our knowledge, these antiphospholipid antibodies, which may inhibit prostacyclin formation and alter platelet function, have not been previously associated with this thymic neoplasm, an association we believe is not coincidental.
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D002308:Cardiolipins / Q000032:analysis*; D002544:Cerebral Infarction / Q000209:etiology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D012008:Recurrence; D013934:Thymectomy; D013945:Thymoma / Q000150:complications* / Q000276:immunology; D013953:Thymus Neoplasms / Q000150:complications* / Q000276:immunology
D001323:Autoantibodies; D002308:Cardiolipins; D007074:Immunoglobulin G; D007075:Immunoglobulin M