Effect of mannozym on the chemiluminescence of phagocytes.
Mannozym (zymosan) induces chemiluminescence (CL) in human neutrophils, monocytes and in the cells of C4M phi murine macrophage cell line. The CL enhancing effect of Mannozym opsonized in human serum is higher than that of non-opsonized material. This may be due to the capacity of Mannozym to bind complement components and immunoglobulins from serum and to activate the phagocytes via their C3b and Fc receptors. Besides, Mannozym can be phagocytosed both in opsonized and non-opsonized forms.
D000818:Animals; D002460:Cell Line; D006801:Humans; D008163:Luminescent Measurements; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D008351:Mannans / Q000494:pharmacology*; D051379:Mice; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D009895:Opsonin Proteins
D008351:Mannans; D009895:Opsonin Proteins; C035480:mannozym