[Advantages of oxythiamine bromide as a specific inhibitor of activity of thiamine-dependent enzymes].
Production of hydrogen bromide salt of hydroxythiamine (Ht. HBr) from thiamine bromide was developed its toxic and inhibitory properties towards transketolase and pyruvate dehydrogenase were studied as compared with commercial preparation hydroxythiamine chloride (HT. HCl). As compared with HT. HCl, synthesis of HT. HBr was more simple, the higher yield and purity of the end product were achieved. At the same time, the preparation was less toxic and exhibited the antivitaminous activity similar to the commercial chloride form.
D000818:Animals; D001921:Brain / Q000201:enzymology; D007928:Lethal Dose 50; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D010119:Oxythiamine / Q000494:pharmacology* / Q000633:toxicity; D011768:Pyruvate Dehydrogenase Complex / Q000037:antagonists & inhibitors*; D013835:Thiamine Pyrophosphate / Q000378:metabolism*; D013844:Thiazoles / Q000494:pharmacology*; D014174:Transketolase / Q000037:antagonists & inhibitors*
D011768:Pyruvate Dehydrogenase Complex; D013844:Thiazoles; D010119:Oxythiamine; D014174:Transketolase; D013835:Thiamine Pyrophosphate
Preimushchestva oksitiaminbromida kak spetsificheskogo ingibitora aktivnosti tiaminzavisimykh fermentov.