Stimulation of human fibroblast collagen synthesis in vitro by gamma-aminobutyric acid.
Human buccal mucosa fibroblasts were exposed in culture to gamma-aminobutyric acid (GABA) and the areca alkaloid arecaidine. Both GABA and arecaidine stimulated collagen synthesis and proliferation in a concentration-dependent manner, with arecaidine consistently producing the greater stimulation. Prior exposure to GABA or arecaidine for 5 days caused the cells to become insensitive when challenged with either drug.
D001115:Arecoline / Q000031:analogs & derivatives / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
C015688:arecaidine; D001115:Arecoline; D005680:gamma-Aminobutyric Acid; D003094:Collagen