Serotonin uptake in blood platelets of Duchenne muscular dystrophy patients.
Serotonin (5-HT) uptake was studied in the blood platelets of 10 patients with Duchenne-type muscular dystrophy (DMD) and 7 age-matched controls. Vmax (maximum number of uptake sites) of platelet 5-HT uptake in the DMD patients was significantly less than that of the normal controls. There was no difference in the affinity for 5-HT (Km) between the two groups. There was a significant negative correlation between serum creatine kinase activity and Km of 5-HT uptake in blood platelets of these patients. However, no correlation was found between Km or Vmax and ambulatory status of DMD.
D000293:Adolescent; D001792:Blood Platelets / Q000378:metabolism*; D002648:Child; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D009136:Muscular Dystrophies / Q000097:blood*; D012016:Reference Values; D012701:Serotonin / Q000097:blood*
D012701:Serotonin; D003402:Creatine Kinase