Splenic haematocrit and the splenic plasma pool.
A method was established for estimation of plasma volume and splenic plasma pool by quantitative scanning using 113mIn labelled transferrin (TF). The method was used in 12 patients with various haematological disorders and degrees of splenomegaly. 113mIn-TF consistently gave about 6% over-estimation of plasma volume by comparison with the standard 125I HSA method. The splenic plasma pool ranged from 1.2% to 11.4% of the total plasma volume. By concurrent measurement of splenic red cell pool the splenic haematocrit (SHct) was obtained: mean 0.51, SD 0.08; the SHct/PCV ratio was 1.21 (SD 0.31) and the SHct/body Hct ratio was 1.30 (SD 0.30). SHct was independent of PCV and body Hct but there was a trend to a lower SHct in cases where splenomegaly was more marked. Direct measurement of splenic plasma pool may help to elucidate the cause of increased total plasma volume in such patients.
D000328:Adult; D000368:Aged; D004911:Erythrocyte Volume; D005240:Feasibility Studies; D005260:Female; D006400:Hematocrit; D006801:Humans; D007204:Indium; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D010953:Plasma Volume; D011868:Radioisotopes; D013154:Spleen / Q000503:physiopathology*; D013163:Splenomegaly / Q000097:blood* / Q000503:physiopathology
D007457:Iodine Radioisotopes; D011868:Radioisotopes; D007204:Indium