Effects of cholinesterase reactivators and atropine on fenitrothion-induced hypothermia in Bubalus bubalis.
Oral administration of fenitrothion (435 mg/kg) produced a pronounced fall in rectal temperature and erythrocyte AChE activity in buffalo calves. Treatment with DAM alone or in conjunction with atropine at the time of severe toxicity (within 1 h) significantly (P less than 0.01) reversed fenitrothion-induced hypothermia and AChE inhibition. The temperature decrease and AChE inhibition were not significantly (P greater than 0.05) altered by either 2-PAM or atropine. It is concluded that DAM may be more effective than either 2-PAM or atropine in reversing hypothermic effect of OP insecticides.
D000110:Acetylcholinesterase / Q000097:blood*; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D002020:Buffaloes; D002074:Butanones / Q000494:pharmacology*; D002801:Cholinesterase Reactivators; D003931:Diacetyl / Q000031:analogs & derivatives / Q000494:pharmacology*; D004912:Erythrocytes / Q000201:enzymology*; D005278:Fenitrothion / Q000633:toxicity*; D007035:Hypothermia / Q000139:chemically induced*; D011220:Pralidoxime Compounds / Q000494:pharmacology*
D002074:Butanones; D002801:Cholinesterase Reactivators; D011220:Pralidoxime Compounds; C004717:diacetylmonoxime; D001285:Atropine; D000110:Acetylcholinesterase; D003931:Diacetyl; C028797:pralidoxime; D005278:Fenitrothion