[Effect of euphylline and no-shpa on cerebrovascular resistance and the survivability of animals after cerebral ischemia].
In acute experiments on anesthetized cats with total ischemia of the brain (15-minute arrest of blood autoperfusion of the cerebral vessels by a stable blood volume) it was shown that euphylline and no-shpa administered before ischemia or in the early period after ischemia inhibit or prevent the development of the postischemic phenomenon of non-recovery of the cerebral blood flow. The two drugs contributed to survival of albino rats following the brain ischemia produced by ligation of both carotid arteries.
D000628:Aminophylline / Q000627:therapeutic use*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D005260:Female; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D008297:Male; D010208:Papaverine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010276:Parasympatholytics / Q000627:therapeutic use*; D051381:Rats; D014655:Vascular Resistance / Q000187:drug effects*
D010276:Parasympatholytics; D000628:Aminophylline; C005317:drotaverin; D010208:Papaverine
Vliianie éufillina i no-shpy na tserebrovaskuliarnoe soprotivlenie i vyzhivaemost' zhivotnykh posle ishemii golovnogo mozga.