Racemization and the origin of optically active organic compounds in living organisms.
The organic compounds synthesized in prebiotic experiments are racemic mixtures. A number of proposals have been offered to explain how asymmetric organic compounds formed on the Earth before life arose, with the influence of chiral weak nuclear interactions being the most frequent proposal. This and other proposed asymmetric syntheses give only slight enantiomeric excess and any slight excess will be degraded by racemization. This applies particularly to amino acids where half-lives of 10(5)-10(6) years are to be expected at temperatures characteristic of the Earth's surface. Since the generation of chiral molecules could not have been a significant process under geological conditions, the origins of this asymmetry must have occurred at the time of the origin of life or shortly thereafter. It is possible that the compounds in the first living organisms were prochiral rather than chiral; this is unlikely for amino acids, but it is possible for the monomers of RNA-like molecules.
D000596:Amino Acids; D000818:Animals; D005075:Biological Evolution; D006801:Humans; D009694:Nucleic Acid Precursors; D009904:Optical Rotation; D013237:Stereoisomerism
D000596:Amino Acids; D009694:Nucleic Acid Precursors