[Effect of organic solvents on streptokinase-initiated fibrinolysis].
Proton-developing (ethanol, I-propanol, I-butanol, I-pentanol) and aproton solvents (dioxane, dimethylsulfoxide, dimethylformamide) at concentrations 1.5-50% activated the streptokinase-initiated fibrinolysis. Methanol and acetone were not effective. The rate of fibrinolysis, studied in presence of glycerol and phenol (used at 0.1-9.3% concentrations), depended on concentrations of these reagents in samples. Efficiency of aliphatic alcohols was increased with elongation of hydrocarbonic chain. The activating effect of ethanol was not removed by epsilon-aminocapronic acid 10(-2) M.
D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D012997:Solvents; D013268:Stimulation, Chemical; D013300:Streptokinase / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D012997:Solvents; D013300:Streptokinase
Vliianie organicheskikh rastvoriteleĭ na initsiiruemyĭ streptokinazoĭ fibrinoliz.