title: [Induction of genetic damage by incorporated 238Pu in the germ cells of male mice].
abstract: Frequency of dominant lethal mutation, occurrence of spermatozoa with abnormal heads, and changes in the testis mass were studied after the administration to mice of 238Pu in doses from 7 to 1850 Bq/g. The frequency of genetic lesions in the testis was not a function of alpha-radiation dose. The rate of the testis mass decrease was a linear function of the dose absorbed. RBE of 238Pu-alpha-radiation, as determined by the incidence of abnormal spermatozoa heads and by the changes in the testis mass, was from 14 to 35 with regard to the chronic effect of gamma-radiation.
mesh_terms: D000042:Absorption; D000512:Alpha Particles; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D005799:Genes, Dominant / Q000528:radiation effects; D005804:Genes, Lethal / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009154:Mutation; D009566:Nitrates; D009929:Organ Size / Q000528:radiation effects; D011005:Plutonium / Q000378:metabolism / Q000633:toxicity*; D012062:Relative Biological Effectiveness; D013077:Sperm Head / Q000002:abnormalities / Q000528:radiation effects; D013094:Spermatozoa / Q000378:metabolism / Q000528:radiation effects*; D013737:Testis / Q000528:radiation effects
chemical_list: D009566:Nitrates; C015459:plutonium nitrate; D011005:Plutonium
vernacular_title: Induktsiia geneticheskikh povrezhdeniĭ inkorporirovannym 238Pu v polovykh kletkakh samtsov myshi.