Quantitative study of various factors influencing the migration of lymphocytes in vitro: glucocortico-steroid, PHA, cyclosporin A and heparin.
Various agents known to influence the lymphocyte recirculation in vivo were investigated for their effect on the migration of lymphocytes in 3-D collagen gel. Both glucocortico-steroid and cyclosporin A were shown to inhibit the migration in a dose dependent manner. In contrast heparin and PHA treated lymphocytes migrated at a significantly faster rate.
D002465:Cell Movement / Q000187:drug effects; D003524:Cyclosporins / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D007700:Kinetics; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D010835:Phytohemagglutinins / Q000494:pharmacology*
D003524:Cyclosporins; D010835:Phytohemagglutinins; D006493:Heparin; D006854:Hydrocortisone