title: Effect of corticosterone on the incidence of amelanosis in Smyth delayed amelanotic line chickens.
abstract: The Smyth Delayed Amelanotic (SDA) line chicken exhibits a postnatal loss of pigment in feathers and choroid presumably due to an autoimmune reaction triggered by a basic pigment cell defect. The present study was designed to determine if the incidence and severity of amelanosis would be affected by administration of corticosterone (CS) in feed. The SDA line chickens were given 0, 20, 30, 40, and 50 ppm CS from 4 to 12 weeks of age. Body weight and incidence of amelanosis were determined weekly and immune response to sheep red blood cells was determined at the end of the trials. Body weight and immune response levels were significantly lower in treated groups than in controls (P less than .001), but no significant differences were found between treated groups on measures of amelanosis or immune response. Incidence of amelanosis in controls (60%) was significantly greater than in treated groups: 20 ppm, 14.2%; 30 ppm, 17.9%; 40 ppm, 12.9%; and 50 ppm, 16.7%. Six weeks posttreatment, treated groups were no longer significantly different from controls in terms of the incidence of amelanosis. It is proposed that the reduction in amelanosis during CS treatment is attributable to suppression of antibody response to the pigment cell antigen by the CS.
mesh_terms: D000818:Animals; D002645:Chickens / Q000235:genetics*; D003345:Corticosterone / Q000494:pharmacology*; D005241:Feathers; D005260:Female; D008297:Male; D010858:Pigmentation / Q000187:drug effects*; D010859:Pigmentation Disorders / Q000662:veterinary*; D011201:Poultry Diseases / Q000276:immunology*
chemical_list: D003345:Corticosterone