Cerebral ischemia-reperfusion injury in the gerbil.
Gerbils subjected to cerebral ischemia (unilateral carotid occlusion for 6 hr) were either asymptomatic or developed increasingly severe neurologic deficits which correlated with degrees of brain swelling (weights of ischemic hemisphere versus the contralateral control hemispheres) following 3 hr of reperfusion. Asymptomatic gerbils or gerbils suffering only mild deficits survived for 1 week following reperfusion while gerbils suffering moderate to severe deficits had a poor survival rate with only 22% remaining alive after 1 week.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001929:Brain Edema / Q000209:etiology*; D002339:Carotid Arteries; D002560:Cerebrovascular Circulation; D003250:Constriction; D005260:Female; D005849:Gerbillinae; D006429:Hemiplegia / Q000209:etiology; D002546:Ischemic Attack, Transient / Q000150:complications / Q000401:mortality / Q000503:physiopathology*; D008297:Male