Effect of glucan on Leishmania major infection in BALB/c mice.
The effect of glucan on Leishmania major infection was studied in BALB/c mice, which are highly susceptible to leishmania infection. Glucan (0.45 mg), or isovolumetric dextrose, was administered intraperitoneally 7, 5, 3 and 1 day before infection with L. major promastigotes. At 3, 5, 6, 8 and 10 weeks after infection, animals were killed; the liver and spleen of each animal were weighed and the parasite burden was calculated. A significant (p less than 0.01) reduction in amastigote proliferation in liver and spleen of animals pretreated with glucan was demonstrated 4, 6 and 8 weeks after infection.
D000818:Animals; D005936:Glucans / Q000494:pharmacology*; D007895:Leishmania tropica / Q000254:growth & development*; D007896:Leishmaniasis / Q000469:parasitology* / Q000473:pathology; D008099:Liver / Q000469:parasitology* / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size; D013154:Spleen / Q000469:parasitology* / Q000473:pathology; D013997:Time Factors
D005936:Glucans