[Structural and chemical transformations of heat-processed polyacrylonitrile fibers and characteristic parameters of their interactions with thrombocytes and plasma proteins].
A suitable for analysis of the effect of structural and chemical changes on haemocompatibility of polymers is polyacrylonitrilics (PNA), which, depending on the thermo-processing (temperature, medium), make a number of materials, differing in structure and properties. A comparative analysis of physical and chemical initial properties as well as of thermically processed PNA fibres was made. By the methods of radioisotope and of fluoroscent spectroscopy the kinetics of early stages of adsorption of plasma albumine (AS) and of plasma fibrinogen (FG), the kinetics of desorption of pre-adsorbed plasma albumine in a model solution, and thrombocyte adhesion of the PNA surface were studied. The extreme nature of the irreversability degree in albumine and fibrinogen adsorption, the effective coefficients of the albumine desorption speed, and the number of bound thrombocytes at the temperature increase in thermal processing were found, and better quantitative criteria of haemocompatibility in vitro for PNA, processed thermally in the air. The achieved results can be explained by occurrence of, in a number of studied PNA fibres, an optimum ratio of the dispertion and polar superficial surrounding energy.
D000042:Absorption; D000180:Acrylic Resins / Q000494:pharmacology; D001672:Biocompatible Materials; D005340:Fibrinogen / Q000378:metabolism*; D006358:Hot Temperature; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects*; D012709:Serum Albumin / Q000378:metabolism*; D013499:Surface Properties
D000180:Acrylic Resins; D001672:Biocompatible Materials; D012709:Serum Albumin; C010504:polyacrylonitrile; D005340:Fibrinogen
Strukturno-khimicheskie prevrashcheniia termoobrabotannykh poliakrilonitril'nykh volokon i kharakteristicheskie parametry ikh vzaimodeĭstviias trombotsitami i belkami plazmy krovi.