title: Prevention of amphetamine-induced behavioral hypersensitivity by concomitant treatment with microgram doses of apomorphine.
abstract: Behavioral hypersensitivity induced by subchronic administration of amphetamine in mice was inhibited by concomitant administration of apomorphine in microgram doses. Acutely, amphetamine followed in 15 min by apomorphine, produces a normal rise in locomotor activity subsequent to the action of amphetamine and an inhibition of that activity by the modulatory action of apomorphine. We suggest that apomorphine acts at a presynaptic neuronal site to interrupt the process(es) responsible for the development of stimulant-induced sensitization.
mesh_terms: D000661:Amphetamine / Q000037:antagonists & inhibitors*; D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*
chemical_list: D000661:Amphetamine; D001058:Apomorphine