title: Effect of environmental temperature on thermal response to chlorpromazine. II. Simulation of hypothermia in rats.
abstract: Thermal response of rats to chlorpromazine (CPZ) was determined at low (15 degrees C) and high (28 degrees C) environmental temperature. Effects of CPZ at ambient temperature of 5-33 degrees C were estimated using a drug disposition-thermoregulation model reported previously. The simulation revealed that the hypothermic effect of CPZ is greater in cold environment and is suppressed in hot environment.
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D004781:Environmental Exposure; D008297:Male; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D013696:Temperature
chemical_list: D002746:Chlorpromazine