The effect of amitriptyline on the central nervous system penetration of methotrexate.
The reported ability of amitriptyline to enhance the penetration of diffusion limited substances across the blood brain barrier was investigated. The CSF:plasma ratio of methotrexate in primates was not significantly altered by amitriptyline pretreatment. Nor was methotrexate plasma clearance altered.
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004347:Drug Interactions; D008253:Macaca mulatta; D008727:Methotrexate / Q000097:blood / Q000134:cerebrospinal fluid*
D000639:Amitriptyline; D008727:Methotrexate