title: Potential antitumor agents: steroidal amidoesters with an alkylating moiety.
abstract: 17 beta-Acetamido-5-androsten-3 beta-ol-p-bis(2-chloroethyl) aminophenylacetate and 17 beta-acetamido-5 alpha-androstan-3 beta-ol-p-bis(2-chloroethyl)aminophenylacetate, amido steroidal alkylating agents, were investigated in L1210 and P388 leukemias, Ehrlich ascites tumor, and adenocarcinoma CA-755. Both substances were determined to increase the life span of the tumor-bearing animals and to cause several long-term survivors in adenocarcinoma CA-755.
mesh_terms: D000477:Alkylating Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000732:Androstanols / Q000008:administration & dosage / Q000627:therapeutic use*; D000737:Androstenols / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004285:Dogs; D004341:Drug Evaluation; D005260:Female; D007928:Lethal Dose 50; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009588:Nitrogen Mustard Compounds / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000477:Alkylating Agents; D000732:Androstanols; D000737:Androstenols; D000970:Antineoplastic Agents; D009588:Nitrogen Mustard Compounds; C052283:17-acetamido-5-androsten-3-ol-4-bis(2-chloroethyl)aminophenylacetate; C052284:17-acetamido-5-androstan-3-ol-4-bis(2-chloroethyl)aminophenylacetate