WF-3405, a novel antitumor antibiotic. Taxonomy, isolation, structure elucidation and biological properties.
A new antitumor antibiotic, WF-3405 was isolated from the culture of Amauroascus aureus F-3405. The structure has been determined as 1,5-dioxiranyl-1,2,3,4,5-pentanepentanol on the basis of spectroscopic and chemical evidence. WF-3405 exhibits strong inhibitory activity against various murine tumors including leukemia P388, leukemia L1210 and Lewis lung carcinoma.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D004852:Epoxy Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D004988:Ethers, Cyclic / Q000302:isolation & purification*; D005260:Female; D005285:Fermentation; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D000439:Pentanols / Q000302:isolation & purification* / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D000439:Pentanols; C052099:1,5-dioxiranyl-1,2,3,4,5-pentanepentanol