The duration of contact photosensitivity to TCSA in the mouse.
We examined the course and duration of contact photosensitivity (CPS) to 3,3', 4',5-tetrachlorosalicylanilide (TCSA) in BALB/cJ mice. The doses of TCSA and UVA at sensitization and challenge were kept constant and the time between sensitization and challenge was varied between 4 days and 9 weeks. A small increase in ear swelling was seen at the 4-d challenge with a further increase at 5 d. The peak challenge response was reached at 7 d. Gradually decreased reactions were found at challenges 2,3 and 5 wk after sensitization and, at 7 and 9 wk challenges, sensitization was not detected. Resensitization of the 9-wk group, with challenge a week later, produced a good reaction though not a maximum one, thus the waning of sensitization was not due solely to active suppression.
D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D012457:Salicylamides / Q000633:toxicity*; D012458:Salicylanilides / Q000633:toxicity*; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects
D012457:Salicylamides; D012458:Salicylanilides; C003390:3,3',4',5-tetrachlorosalicylanilide