[Biotransformation and pharmacokinetics of bamipine in rats. 1. biotransformation].
Biotransformation and Pharmacokinetics of Bamipine in Rats/1st Communication: Biotransformation studies. The metabolism of the antihistaminic N-phenyl-N-benzyl-4-amino-1-methylpiperidine (bamipine) was investigated after oral application in Wistar rats. The major metabolites in the urine were the ether glucuronides of N-p-hydroxy-phenyl-N-benzyl-4-amino-1-methylpiperidine and of N-p-hydroxyphenyl-N-benzyl-4-amino-piperidine. Unchanged drug was not detected. In vitro studies showed, in good correlation with in vivo studies, a oxidative demethylation of bamipin.
D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006633:Histamine Antagonists / Q000378:metabolism* / Q000652:urine; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D010880:Piperidines / Q000378:metabolism* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
D006633:Histamine Antagonists; D010880:Piperidines; C020867:bamipine
Biotransformation und Pharmakokinetik von Bamipin an Ratten. 1. Mitteilung: Untersuchungen zur Biotransformation.