Age-related changes in trimethadione oxidizing capacity.
The metabolism of trimethadione (TMO) following oral administration (4 mg kg-1) has been studied in 11 young male and 11 elderly male patients. The elimination half-life (h) of TMO was 11.8 +/- 1.4 (mean +/- s.e. mean) in the young and 23.5 +/- 2.17 in the elderly (P less than 0.01). Total body clearance (1 h-1 kg-1) was 41.4 +/- 2.8 in the young and 29.0 +/- 2.4 in the elderly (P less than 0.01). The apparent volume of distribution (1 kg-1) was 0.67 +/- 0.03 in the young and 0.65 +/- 0.04 in the elderly. Serum dimethadione (DMO)/TMO ratios at 4 h were 0.65 +/- 0.03 in the young and 0.46 +/- 0.03 in the elderly (P less than 0.01). These results suggest that N-demethylation of TMO is inversely related to age.
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D004114:Dimethadione / Q000097:blood; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010080:Oxazoles / Q000097:blood*; D010084:Oxidation-Reduction; D012709:Serum Albumin / Q000378:metabolism; D014293:Trimethadione / Q000097:blood*
D010080:Oxazoles; D012709:Serum Albumin; D004114:Dimethadione; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D014293:Trimethadione