[Effect of soybean trypsin inhibitor and chicken ovomucoid on the immunogenic and sensitizing properties of various dietary proteins].
Adult male guinea pigs were sensitized by intragastric administration of bovine serum albumin (BSA) and chick ovalbumin (OA) and their mixtures with soybean Kunitz trypsin inhibitor (SBTI) and chick ovomucoid (OM). Sensitization of the animals was evaluated by the anaphylactic shock reaction and also by the levels of serum specific IgG antibodies against BSA and OA as measured in the solid phase radioimmunoassay. The experiment revealed pronounced desensitizing properties of SBTI combined both with OA and BSA. OM produced no effect on the animal sensitization caused by OA and enhanced the BSA-induced sensitization. The results obtained demonstrate the necessity of differential approach to the evaluation of the action of varying trypsin inhibitors on food sensitization.
D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D000917:Antibody Formation; D004044:Dietary Proteins / Q000008:administration & dosage*; D004527:Egg Proteins / Q000008:administration & dosage*; D005512:Food Hypersensitivity / Q000209:etiology* / Q000276:immunology; D006168:Guinea Pigs; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology*; D010059:Ovomucin / Q000008:administration & dosage*; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000276:immunology*; D014360:Trypsin Inhibitor, Kunitz Soybean / Q000008:administration & dosage*; D014361:Trypsin Inhibitors / Q000008:administration & dosage*
D004044:Dietary Proteins; D004527:Egg Proteins; D007074:Immunoglobulin G; D014361:Trypsin Inhibitors; D012710:Serum Albumin, Bovine; D010059:Ovomucin; D010047:Ovalbumin; D014360:Trypsin Inhibitor, Kunitz Soybean
Vliianie soevogo ingibitora tripsina i kurinogo ovomukoida na immunogennye i sensibiliziruiushchie svoĭstva nekotorykh pishchevykh belkov.