[The adrenal medulla and adrenergic innervation of the ventricles of the heart during the postnatal period of ontogenesis of the white rat (histofluorescent study)].
The sympathetic innervation of the cardiac ventricles and dynamics of catecholamine contents in the adrenal medulla have been investigated in inbred white rats (1-3-week-old, immature, mature and old animals). During 1-3 weeks of age, development of adrenergic innervation of the heart is observed, in 1.5-month-old rats in approaches that in mature animals. In the old rats the arrangement density and fluorescent intensity of the adrenergic terminals of the cardiac ventricles in comparison to those in the mature animals decreases considerably. Catecholamine contents in the adrenal medulla in 3-week-old rats practically reaches those specific for mature animals. In the old animals the amount of catecholamines in the adrenal medulla decreases by 20%, comparing to those in the mature animals. Thus, maturation of the mediator link of the sympatho-adrenomedullary system is performed in it later than the hormonal one, while processes of old age involution are more intensive.
D000313:Adrenal Medulla / Q000378:metabolism*; D000320:Adrenergic Fibers / Q000378:metabolism; D000367:Age Factors; D000375:Aging / Q000378:metabolism / Q000473:pathology; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D006321:Heart / Q000294:innervation*; D006352:Heart Ventricles; D008856:Microscopy, Fluorescence; D051381:Rats; D013564:Sympathetic Nervous System / Q000033:anatomy & histology*
D002395:Catecholamines
Mozgovoe veshchestvo nadpochechnikov i adrenergicheskaia innervatsiia zheludochkov serdtsa v postnatal'nom periode ontogeneza beloĭ krysy (gistofliuorestsentnoe issledovanie).