Synthesis of O2'-methyluridine, O2'-methylcytidine, N4,O2'-dimethylcytidine and N4,N4,O2'-trimethylcytidine from a common intermediate.
A facile synthesis of the title compounds from a readily accessible precursor, 3',5'-O-bis-protected O4-(2-nitrophenyl)uridine, is described.
D055598:Chemical Phenomena; D002621:Chemistry; D003562:Cytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D009682:Magnetic Resonance Spectroscopy; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
C052204:N(4), O(2')-dimethylcytidine; C052205:N(4), N(4), O(2')-trimethylcytidine; C052202:2'-O-methyluridine; C052203:2'-O-methylcytidine; D003562:Cytidine; D014529:Uridine