[Prospective study of administering a single-dose prophylactic antibiotic in primarily indicated abdominal cesarean section].
A prospective study was carried out with the participation of 60 pregnant women to elucidate the question if a unilateral antibiotic-prophylaxis is also indicated for a primary caesarean section. With the help of a random-list two collectives were formed with 30 pregnant women each. After delivery of the child one collective was given 4 g Mezlocillin (Baypen) i.v., the other collective did not receive an antibiotic. We analyzed the postoperative period of storage, postoperative fever, postoperative quality of healing, endometritis, urinary tract infection and the necessity of a postoperative antibiotic therapy. In addition we investigated swabs of the ear of the newborn, swabs from the cervix of the mother and blood culture of umbilical vein. Significantly less postoperative disorder of healing could be observed in the prophylaxis collective. All other investigated parameters did not show any significant differences in both collectives. Also there were no significant differences of infections in both collectives, therefore there is no indication for an antibiotic prophylaxis at a primary caesarean section.
D002585:Cesarean Section; D004334:Drug Administration Schedule; D004716:Endometritis / Q000517:prevention & control; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008802:Mezlocillin / Q000627:therapeutic use*; D011247:Pregnancy; D011446:Prospective Studies; D011645:Puerperal Infection / Q000517:prevention & control; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014552:Urinary Tract Infections / Q000517:prevention & control; D014945:Wound Healing / Q000187:drug effects
D008802:Mezlocillin
Prospektive Studie zur einzeitigen Antibiotikaprophylaxe bei primär indizierter abdominaler Schnittentbindung.