Hyperplastic gingivitis during diltiazem therapy.
This report concerns a patient with ischemic heart disease, who developed hyperplastic gingivitis with verapamil. The gingivitis resolved completely when the drug was discontinued, but recurred when another calcium antagonist, diltiazem, was administered. It is suggested that it is the mechanism of action of calcium antagonists which is responsible for the gingival changes.
D002121:Calcium Channel Blockers / Q000009:adverse effects; D004110:Diltiazem / Q000009:adverse effects*; D005881:Gingiva / Q000473:pathology; D005891:Gingivitis / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D014700:Verapamil / Q000009:adverse effects
D002121:Calcium Channel Blockers; D014700:Verapamil; D004110:Diltiazem