title: [The detrimental effect of iodine as an intra-uterine instillation in mares].
abstract: Fifty ml of a 0.2% iodine solution were instilled into the uteri of six mares selected for culling. Biopsy specimens were taken for microscopic examination before the commencement of the experiment and at various times over the course of a year after the single instillation. Severe oedema and haemorrhage was present in the lamina propria of all the post-instillation biopsy specimens. The epithelium showed vacuolisation and necrosis, as well as focal areas of epithelial loss. In some cases hyperplasia or metaplasia was seen. Cell infiltration was characterized by the presence of neutrophils, eosinophils and mild lymphocyte infiltration around the blood vessels. Leukostasis was present around the blood vessels in some specimens. Blood vessel changes were characterized in the early stages by oedema of the tunica media of the medium-sized arteries and later by arteriosclerosis with the complete obliteration of the lumen of the particular vessels in some cases. The endometrial glands showed hyperplasia and mitotic figures were more often seen in these glands than normal. The most pronounced lesion in the later stage of the experiment was fibrosis of the lamina propria with the resultant collapse of the stratum compactum and contraction of the stratum spongiosum. The severe fibrosis of the endometrium is the most probable reason for infertility in mares treated with iodine.
mesh_terms: D000818:Animals; D004717:Endometrium / Q000473:pathology; D005260:Female; D006734:Horse Diseases / Q000139:chemically induced*; D006736:Horses; D007247:Infertility, Female / Q000139:chemically induced / Q000662:veterinary*; D007455:Iodine / Q000009:adverse effects*; D008297:Male; D013997:Time Factors
chemical_list: D007455:Iodine
vernacular_title: Die skadelike gevolg van intra-uterine toediening van jodium by merries.