Comparative sensitivities of avian neural esterases to in vitro inhibition by organophosphorus compounds.
The inhibitory power of organophosphorus compounds in vitro was compared against neurotoxic esterase (also known as neuropathy target esterase, NTE), acetylcholinesterase and carboxylesterase activities in brains from chickens, turkeys, quail and rats. Brains from the species most susceptible to clinical signs of organophosphorus-induced delayed neuropathy (chicken, turkey) contained more NTE than did rat and quail. Higher concentrations of organophosphorus compounds were required to inhibit rat NTE and quail acetylcholinesterase than were necessary for inhibition of these enzymes in chicken and turkey brains. Total carboxylesterase and acetylcholinesterase activities were less in rats than in the avian species.
D000818:Animals; D001717:Birds; D001921:Brain / Q000201:enzymology*; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors; D004950:Esterases / Q000037:antagonists & inhibitors*; D005260:Female; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced; D009943:Organophosphorus Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D009943:Organophosphorus Compounds; D004950:Esterases; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase