title: [Metabolism of the inhibitor of fibrin self-assembly in rats].
abstract: It has been shown that the application of the labelled preparation in physiologically normal white rats and in animals with experimental hyper- and hypothrombinemia leads to the rapid exchange of the peptide self-assembly inhibitor between the blood and extravascular space. The constant level of the inhibitor in the blood is maintained due to continuous supply from tissues and its excretion with the urine. The role and mechanisms of the inhibitor involvement into the maintenance of the liquid state of the blood as a factor limiting the speed of nonenzymatic stage of fibrinogen conversions are suggested.
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D005017:Ethyl Biscoumacetate / Q000494:pharmacology; D005337:Fibrin / Q000037:antagonists & inhibitors*; D006801:Humans; D007457:Iodine Radioisotopes; D008970:Molecular Weight; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D013917:Thrombin / Q000378:metabolism / Q000494:pharmacology; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D010455:Peptides; D005017:Ethyl Biscoumacetate; D005337:Fibrin; C052940:fibrin self-assembly inhibitor; D013917:Thrombin
vernacular_title: Obmen ingibitora samosborki fibrina u krys.