[Toxicity of rubomycin 13-cyclohexylidene hydrazone].
The systemic effect and toxicity of rubomycin 13-cyclohexylidene hydrazone (RCH) were studied in comparison to those of rubomycin on noninbred albino mice. The drugs were used intravenously in single doses or a course consisting of 5 injections. When used intravenously in a single dose RCH was 2 times less toxic than rubomycin. RCH differed from rubomycin by the character of animal death: the former induced death of the animals immediately after its intravenous administration, while with the use of the latter the animals died within the first 5-10 days after the drug injection. When used during the treatment course including 5 intravenous injections in doses of 0.45 or 0.3 of LD50, the inhibitory effects of the drugs on hemopoiesis were similar by their nature, RCH had a more pronounced cardiotoxic effect than rubomycin.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D013329:Structure-Activity Relationship; D013997:Time Factors
C051959:rubomycin 13-cyclohexylidenehydrazone; D003630:Daunorubicin
Izuchenie toksichnosti 13-tsiklogeksilidengidrazona rubomitsina.