title: Chemoprevention by antineoplaston A10 of benzo(a)pyrene-induced pulmonary neoplasia.
abstract: The effect of Antineoplaston A10 (AA10), an amino acid derivative isolated from human urine, has been studied on pulmonary adenoma formation resulting from intragastric administration of benzo(a)pyrene(BP) to A/HeJ mice. Two doses of BP, 3 mg each, administered two weeks apart, induced an average of 6.86 tumours within 157 days in the control animals (Tumorigenic Index 437). One per cent of AA10 (w/w) given in mouse food for one week prior to, and then continued after the administration of BP, produced a 70% reduction in the total number of tumours in the test groups.
mesh_terms: D000236:Adenoma / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D044482:Benzeneacetamides; D001564:Benzo(a)pyrene; D001835:Body Weight / Q000187:drug effects; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D008805:Mice, Inbred A; D010880:Piperidines / Q000627:therapeutic use*; D010881:Piperidones
chemical_list: D000970:Antineoplastic Agents; D044482:Benzeneacetamides; D010880:Piperidines; D010881:Piperidones; C052091:antineoplaston A10; D001564:Benzo(a)pyrene