Differences in lymphocyte mitogenic stimulation pattern depending on anaesthesia and operative trauma: I. Halothane-nitrous oxide anaesthesia.
Cell-mediated immunity (investigated by in vitro mitogen/antigen induced lymphocyte proliferation) is known to be depressed in the post-operative period. In the present investigation, performed with halothane/nitrous oxide inhalational anaesthesia in healthy patients without trauma (eye surgery) and with operative tissue trauma (gynaecological operations), only the combination of major surgery with halothane/nitrous oxide anaesthesia was associated with a depression of lymphocyte reactivity to phytohaemagglutin (PHA-P), Concanavalin A (Con A) and pokeweed mitogen (PWM). This lasted for 3-10 days post-operatively.
D000328:Adult; D003208:Concanavalin A / Q000494:pharmacology; D005128:Eye Diseases / Q000601:surgery*; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006221:Halothane / Q000008:administration & dosage*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide / Q000008:administration & dosage*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology
D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A; D009609:Nitrous Oxide; D006221:Halothane