title: Midazolam sedation following open heart surgery.
abstract: Midazolam given as hourly intermittent injections was compared with the same dose given by infusion for postoperative sedation in patients after cardiopulmonary bypass. A stable concentration was rapidly attained with the infusion whereas 6-8 h was required to attain stable plasma (trough) concentrations in the intermittent injection group. Plasma concentrations decreased rapidly to low values within 6 h of discontinuation of therapy. High plasma concentrations and a long (16 h) half-life were noted in one patient who may be a slow metabolizer of the drug.
mesh_terms: D000328:Adult; D006348:Cardiac Surgical Procedures; D006207:Half-Life; D006801:Humans; D006993:Hypnotics and Sedatives; D007700:Kinetics; D008874:Midazolam / Q000378:metabolism; D011182:Postoperative Care
chemical_list: D006993:Hypnotics and Sedatives; D008874:Midazolam