Acute effects of short-term subcutaneous terbutaline on theophylline disposition.
Theophylline and subcutaneous terbutaline are frequently used concurrently in the management of acute asthma. Recent evidence demonstrating a reduction in theophylline serum concentrations during concomitant oral terbutaline therapy prompted our evaluation of subcutaneous terbutaline's effect on theophylline pharmacokinetics. Using a randomized, placebo controlled, crossover design, the disposition of a single oral theophylline dose (7 mg/kg) was studied in eight healthy, adult males before and after repeated subcutaneous administration of terbutaline (0.25 mg). Two-way analysis of variance revealed no significant difference in elimination rate constant (ke), area under the concentration-time curve (AUC), or apparent oral clearance (CL/F) of theophylline following terbutaline administration. These results indicate that subcutaneous administration of terbutaline does not alter the pharmacokinetics of single, oral doses of theophylline in adults.
D000328:Adult; D006801:Humans; D007279:Injections, Subcutaneous; D007700:Kinetics; D008297:Male; D013726:Terbutaline / Q000008:administration & dosage / Q000494:pharmacology*; D013806:Theophylline / Q000378:metabolism*
D013806:Theophylline; D013726:Terbutaline