Identification of a human erythroid cell surface antigen by monoclonal antibody HAE9.
A noncytotoxic monoclonal antibody (IgM) HAE9 that selectively binds to 36% CFU-E and more than 90% nucleated erythroid cells in human bone marrow is described. This antibody recognizes a 70-kDa-membrane protein. It is suggested that HAE9 is directed to a human epitope of Ag-Eb, an interspecies mammalian erythroid-specific cell surface marker.
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D002454:Cell Differentiation; D002460:Cell Line; D004910:Erythrocyte Membrane / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D004920:Erythropoiesis; D005434:Flow Cytometry; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D008099:Liver / Q000196:embryology / Q000276:immunology; D008970:Molecular Weight
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface