Muscarinic agonist binding in rat brain following chronic nicotine treatment.
Carbamylcholine binding was determined from competition experiments with [3H] quinuclidinyl benzilate in the rat brain chronically treated with nicotine. The nicotine group exhibited about two-fold lower affinity for the agonist binding toward a high-affinity site (or state) in the cerebral cortex, as compared with the control group. However, no alteration in the agonist binding was observed in the hypothalamus/thalamus and brainstem after chronic nicotine treatment.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D001933:Brain Stem / Q000187:drug effects; D002217:Carbachol / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects; D007031:Hypothalamus / Q000187:drug effects; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000187:drug effects* / Q000378:metabolism; D013788:Thalamus / Q000187:drug effects
D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate; D009538:Nicotine; D002217:Carbachol