Myeloencephalopathy with eosinophilic refractile bodies (Rosenthal fibers) in a Scottish terrier.
Myeloencephalopathy with diffuse Rosenthal fiber formation (Alexander's disease) was detected in a 9-month-old Scottish Terrier with progressive tetraparesis. Additional abnormalities included an electroencephalogram characteristic of an encephalopathy and a narrowed intervertebral disk space at C2-3. The diagnosis of Alexander's disease is uncommon in human and veterinary medicine. Results from this case and previous reports suggest that this disease in the dog may have a congenital or genetic basis.
D000818:Animals; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004802:Eosinophilia / Q000662:veterinary*; D006801:Humans; D008297:Male; D013118:Spinal Cord Diseases / Q000662:veterinary*