Necrotising haemorrhagic encephalomyelopathy in an adult: Leigh's disease.
A 21 year old male, well-nourished and non-alcoholic, died after five weeks illness. He had suffered epileptic fits, bilateral internuclear ophthalmoplegia, bulbar and pontine paralysis, tetraparesia, ataxia and dystonia. A CT brain scan showed low density lesions of the striatum bilaterally. Post-mortem studies revealed pathological anomalies compatible with Leigh's disease, although the presence of haemorrhages and involvement of the mamillary bodies could also suggest Wernicke's encephalopathy.
D000328:Adult; D001921:Brain / Q000473:pathology; D001928:Brain Diseases, Metabolic / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000473:pathology; D006801:Humans; D007888:Leigh Disease / Q000473:pathology*; D008297:Male; D013116:Spinal Cord / Q000473:pathology; D014057:Tomography, X-Ray Computed