title: Solubility properties in biological media 9: prediction of solubility and partition of organic nonelectrolytes in blood and tissues from solvatochromic parameters.
abstract: Solubilities in and partition among human blood, brain, lung, kidney, muscle, and fat tissue are well correlated by linear solvation energy relationships of the form: XYZ = XYZo + mVI/100 + s pi + b beta m where XYZ is the logarithm of the solubility property, VI is the intrinsic (van der Waals') molar volume, pi and beta are the solvatochromic parameters that measure solute dipolarity/polarizability and hydrogen-bond acceptor basicity, respectively, and the subscript m indicates that for self-associating compounds, the parameter applies to the non-self-associated "monomer" solute. The equation for log K(brain--blood) indicates that increasing molar volume favors, whereas increasing dipolarity and hydrogen-bond acceptor basicity oppose, solute transfer from blood into brain.
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005223:Fats / Q000032:analysis; D006801:Humans; D004364:Pharmaceutical Preparations / Q000097:blood / Q000378:metabolism*; D012995:Solubility; D012997:Solvents
chemical_list: D005223:Fats; D004364:Pharmaceutical Preparations; D012997:Solvents