Biosynthesis of the antibiotic actinorhodin. Analysis of blocked mutants of Streptomyces coelicolor.
From two types of class V act mutants of Streptomyces coelicolor two monomeric precursors of actinorhodin have been isolated and their structures determined. One is the known antibiotic kalafungin and the other a new compound. Their relationship to actinorhodin biosynthesis is discussed.
D000880:Anthraquinones / Q000096:biosynthesis / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification; D055598:Chemical Phenomena; D002621:Chemistry; D002942:Circular Dichroism; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D009285:Naphthoquinones / Q000096:biosynthesis / Q000302:isolation & purification; D013302:Streptomyces / Q000378:metabolism*; D000095622:Benzoisochromanequinones
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; C013079:kalafungin; D000095622:Benzoisochromanequinones; C013390:actinorhodin