[The role of inflammation in the spontaneous elimination of Strongyloides ratti infestation].
In order to assess the role of inflammation and its components in spontaneous cure of Strongyloides ratti infestation, rats were treated with non-steroid anti-inflammatory agents (indometacin; sodium salicylate) or with antagonists of certain mediators (dexchlorpheniramin; cyproheptadin, promethazin). Results were compared with those obtained in similar treatments of rats infested by other Nematoda which also give rise to spontaneous cure: especially Trichinella spiralis, and Nippostrongylus brasiliensis. Coordinating the various findings made it possible to devise a pattern accounting for the chain of reactions that lead to rejection of the parasite.
D000818:Animals; D002744:Chlorpheniramine / Q000494:pharmacology*; D003533:Cyproheptadine / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology*; D007249:Inflammation; D008297:Male; D009349:Nematode Infections / Q000503:physiopathology; D011398:Promethazine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012980:Sodium Salicylate / Q000494:pharmacology*; D013237:Stereoisomerism; D013321:Strongyloides / Q000187:drug effects / Q000254:growth & development; D013322:Strongyloidiasis / Q000503:physiopathology*
D003533:Cyproheptadine; C018904:dexchlorpheniramine; D002744:Chlorpheniramine; D011398:Promethazine; D012980:Sodium Salicylate; D007213:Indomethacin
Role de l'inflammation dans le déparasitage spontané de Strongyloides ratti.