The effects of methylamphetamine on mood and appetite in depressed patients: a placebo-controlled study.
Methylamphetamine given intravenously as a single 15 mg dose led to a pronounced elevation of mood in 7 out of 21 depressed patients compared to a control injection of sterile water administered on another occasion in random order under double-blind conditions. All 7 responders experienced an increase of VAS self-ratings of hunger in contrast to what has been observed in normal subjects who show a decrease in hunger after amphetamine. The implications of these findings are discussed in the light of monoamine theories of depression and appetite control.
D000328:Adult; D000368:Aged; D001066:Appetite / Q000187:drug effects*; D003866:Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000627:therapeutic use*; D008875:Middle Aged; D011897:Random Allocation
D008694:Methamphetamine