Suppression of aminoacyladenylate synthesis by methyl mercury in vitro and in vivo.
Methyl mercury (MeHg) at a concentration of 20 microM significantly inhibits the synthesis of aminoacyladenylates (AAA) in vitro from serine and histidine, and fails to inhibit AAA synthesis from phenylalanine, leucine, arginine and aspartate. In vivo administration of MeHg (single i.p. injection of 50 nmol/g body weight) leads to 75-80% suppression of AAA synthesis from serine, histidine, phenylalanine, leucine, arginine and aspartate in rat brain tissue.
D000249:Adenosine Monophosphate / Q000031:analogs & derivatives* / Q000096:biosynthesis; D000255:Adenosine Triphosphate / Q000172:deficiency; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D008767:Methylmercury Compounds / Q000633:toxicity*; D010766:Phosphorylation; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D008767:Methylmercury Compounds; D011506:Proteins; D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate