A comparison of X-irradiation and ferrous ion-ascorbate on oxidation of phosphatidylglycerols in multilamellar liposomes.
The effect of ferrous ion-ascorbate and X-radiation on multilamellar liposomes, composed of either completely saturated, unsaturated or a mixture of saturated and unsaturated fatty acids, is reported. Lipid composition is shown to be of critical importance in determining the extent to which peroxidation occurs. Liposomes composed of the mixture of saturated and unsaturated fatty acids are peroxidized to a lesser extent by ferrous ion-ascorbate. The reduced peroxidation is apparently the result of an inhibition mechanism shown by the saturated lipid component. In contrast, liposomes composed of mixed lipids do not reduce the level of peroxidation induced by ionizing radiation. These results show that the composition of liposomes plays a role in determining the extent to which peroxidation occurs when a chemical oxidant is employed, but composition is a negligible factor when ionizing radiation is the oxidant.
D001205:Ascorbic Acid; D007700:Kinetics; D008081:Liposomes; D010084:Oxidation-Reduction; D010715:Phosphatidylglycerols / Q000528:radiation effects; D013329:Structure-Activity Relationship; D014965:X-Rays
D008081:Liposomes; D010715:Phosphatidylglycerols; D001205:Ascorbic Acid