A patient with hereditary spherocytosis and silicosis who developed an IgA(lambda) monoclonal gammopathy.
A patient with hereditary spherocytosis and silicosis who developed an IgA(lambda) monoclonal gammopathy is reported. It was thought that a combination of hereditary factors, a chronic hemolytic stimulus to the reticuloendothelial system and an adjuvant effect provided by presence of diffuse silica might have contributed to the development of monoclonal gammopathy.
D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology*; D007070:Immunoglobulin A; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000209:etiology*; D012829:Silicosis / Q000150:complications*; D013103:Spherocytosis, Hereditary / Q000150:complications*
D007070:Immunoglobulin A