title: Search for microbial insect growth regulators. II. Allosamidin, a novel insect chitinase inhibitor.
abstract: Allosamidin, a novel insect chitinase inhibitor, was isolated from the mycelium of Streptomyces sp. It showed strong inhibitory activity against the chitinases of the silkworm, Bombyx mori, in vitro, and also insecticidal activity by preventing its ecdysis in vivo.
mesh_terms: D000117:Acetylglucosamine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D012831:Bombyx / Q000201:enzymology; D002688:Chitinases / Q000037:antagonists & inhibitors*; D005285:Fermentation; D005944:Glucosamine / Q000031:analogs & derivatives*; D007313:Insecta / Q000187:drug effects; D007306:Insecticides / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism; D014312:Trisaccharides
chemical_list: D007306:Insecticides; D014312:Trisaccharides; C054851:allosamidin; D002688:Chitinases; D005944:Glucosamine; D000117:Acetylglucosamine