The effects of age on carbamazepine pharmacokinetics and adverse effects.
The pharmacokinetics and effect of single oral doses of carbamazepine (400 mg) were compared in a group of six young volunteers aged between 20 and 25 years, and a second group of five elderly volunteers aged between 66 and 84 years. No age related changes in salivary or plasma pharmacokinetics or in psychomotor function were detected.
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000378:metabolism*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects; D011897:Random Allocation; D012463:Saliva / Q000378:metabolism
D002220:Carbamazepine; C012227:carbamazepine epoxide