Bacteria-phagocyte interactions: Fusobacterium-induced secretion of a neutrophil self-regulatory factor.
Direct interaction between Fusobacterium nucleatum and human neutrophils resulted in the secretion of a neutrophil self-regulatory factor(s). The secretion of this factor was bacteria specific, and depended on the integrity of the bacteria cell surface. Factor secretion occurred within 15 min of bacteria--neutrophil interaction. Pre-treatment of neutrophils with cytochalasin B but not sodium fluoride inhibited factor secretion. The factor was sensitive to trypsin and heat treatment. Ultrafiltration experiments showed that it has a molecular weight between 10,000 and 30,000 daltons. Its biologic role may be that of a molecular mediator for the recruitment of resting neutrophils so as to amplify the immunological and inflammatory response.
D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins / Q000378:metabolism*; D001770:Blood Bactericidal Activity; D002634:Chemotaxis, Leukocyte; D003571:Cytochalasin B / Q000494:pharmacology; D005557:Formaldehyde / Q000494:pharmacology; D005673:Fusobacterium / Q000276:immunology*; D006358:Hot Temperature; D006801:Humans; D007700:Kinetics; D008970:Molecular Weight; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism; D010518:Periodontitis / Q000209:etiology; D010587:Phagocytosis; D012969:Sodium Fluoride / Q000494:pharmacology; D014357:Trypsin / Q000494:pharmacology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D005557:Formaldehyde; D003571:Cytochalasin B; D012969:Sodium Fluoride; D014357:Trypsin