Delayed memory dysfunction by transient hypoxia, and its prevention with forskolin.
Rats exposed to 40 min hypoxia 3 h before a one-trial learning passive avoidance task showed impaired memory retention 24 h later. this model was used to assess the ability of forskolin to restore the delayed memory dysfunction. Significant amelioration of memory retention was observed when forskolin (500 micrograms/kg, i.p.) was injected just after hypoxia. Forskolin is suggested to enhance cerebral blood flow and to facilitate memory function through the action of increased cyclic adenosine monophosphate (cAMP).
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D005576:Colforsin / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D000860:Hypoxia / Q000523:psychology*; D008568:Memory / Q000187:drug effects*; D051381:Rats; D011916:Rats, Inbred F344; D012153:Retention, Psychology / Q000187:drug effects*; D013997:Time Factors
D005576:Colforsin