A stochastic repair--misrepair model for the effects of radiation on cells.
The purpose of this paper is to present a stochastic model for effects of radiation on cells. The model includes provisions for lethal effects and for transformation to malignant status. Empirical findings indicate the presence of some repair mechanism in the cells, and a way to incorporate this idea into the model is discussed. Comparisons of the derived survival and transformation probabilities with actual data are favorable. The interpretation of the estimated values leads to questions to be investigated by the experimenters.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D002477:Cells / Q000528:radiation effects*; D004249:DNA Damage; D004260:DNA Repair; D008954:Models, Biological; D013269:Stochastic Processes