Ultrastructural changes in the parenchymal liver cells of rats treated with high doses of rifampicin.
Ultrastructural study of hepatic parenchyma was carried out in female Wistar rats after they had received high doses (400 mg X kg-1) of rifampicin for 1, 2, 4, 6 and 8 days. Morphological changes in the endoplasmic reticulum, Golgi apparatus and mitochondria were observed as early as day 1 of intoxication. These changes corroborate the biochemical data available regarding RFP-induced fatty liver.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005234:Fatty Liver / Q000139:chemically induced*; D005260:Female; D006056:Golgi Apparatus / Q000648:ultrastructure; D008079:Lipoproteins, VLDL / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012270:Ribosomes / Q000648:ultrastructure; D012293:Rifampin / Q000633:toxicity*
D008079:Lipoproteins, VLDL; D012293:Rifampin