Vasoactive intestinal polypeptide and carbachol act synergistically to induce the hydrolysis of inositol containing phospholipids in the rat superior cervical ganglion.
The effects of vasoactive intestinal polypeptide (VIP) and carbachol on inositol lipid breakdown were assayed in isolated rat superior cervical ganglia. We report here that VIP and carbachol act synergistically to stimulate the formation of inositol phosphates. This synergistic interaction may explain the modulatory effect of VIP on the muscarinic transmission in the sympathetic ganglia.
D000818:Animals; D002217:Carbachol / Q000008:administration & dosage*; D004357:Drug Synergism; D005727:Ganglia, Spinal / Q000187:drug effects / Q000378:metabolism*; D006868:Hydrolysis; D007295:Inositol Phosphates / Q000096:biosynthesis*; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013403:Sugar Phosphates / Q000096:biosynthesis*; D014660:Vasoactive Intestinal Peptide / Q000008:administration & dosage*
D007295:Inositol Phosphates; D010743:Phospholipids; D013403:Sugar Phosphates; D014660:Vasoactive Intestinal Peptide; D002217:Carbachol