Histochemical investigation of cervical intraepithelial neoplasia.
An enzyme histochemical method and histomorphological examination were applied in the cases of 37 patients with cytological atypia. Good agreement was found between the presence of aberrant glucose-6-phosphate dehydrogenase (G-6-PD) activity (metabolic atypia) and histopathologically demonstrable dysplasia. Only three women with metabolic atypia showed a normal histopathological picture. The results suggest that enzyme histochemistry may also be a valuable supplement to histopathology in the diagnosis of cervical neoplastic changes.
D000293:Adolescent; D000328:Adult; D002278:Carcinoma in Situ / Q000201:enzymology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D008875:Middle Aged; D009245:NADH Dehydrogenase / Q000378:metabolism; D009252:NADPH Dehydrogenase / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism; D002578:Uterine Cervical Dysplasia / Q000201:enzymology*; D002583:Uterine Cervical Neoplasms / Q000201:enzymology*
D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D009252:NADPH Dehydrogenase; D009245:NADH Dehydrogenase