title: Axotomy increases NADPH-diaphorase staining in rat vagal motor neurons.
abstract: Left cervical vagotomy increased NADPH-diaphorase (NADPH-d) histochemical staining in neuronal perikarya of the ipsilateral dorsal motor nucleus of the vagus (dmnX) and the rostral part of the nucleus ambiguus (nAmb). This effect appeared by 2 days, was maximal around 10 days, and declined by 30 days after vagotomy. Light and dark stained perikarya occurred in dmn X ipsilateral to the vagotomy which could not be explained on the basis of the biochemical or transmitter content of these neurons. It is unlikely that the increases of NADPH-d activity resulted from changes in cholinergic transmission since vagotomy is known to decrease cholinergic enzyme function. Since vagotomy increased both the glucose metabolic rate and NADPH-d staining of dmnX and nAmb in these experiments, it is more likely that these effects represent regenerative metabolic responses to axotomy.
mesh_terms: D000818:Animals; D001345:Autoradiography; D001369:Axons / Q000378:metabolism; D003847:Deoxyglucose / Q000378:metabolism; D005260:Female; D006651:Histocytochemistry; D009046:Motor Neurons / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000378:metabolism*
chemical_list: D003847:Deoxyglucose; D009247:NADH, NADPH Oxidoreductases; D009252:NADPH Dehydrogenase