A complex balanced chromosomal rearrangement in repeated abortions.
A double balanced reciprocal translocation involving four chromosomes, t(1;19;6;14) (1p11; 19p11; 6q25; 14q21), was found in the phenotypically normal husband in a couple referred because of repeated abortions. Reciprocal translocations, t(6;14), had been transmitted by his mother, his father being apparently homozygous for a translocation comprising pairs 1 and 19--t(1;19)(1;19). The genetic consequences of this complex chromosomal rearrangement are analyzed.
D000026:Abortion, Habitual / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D002888:Chromosomes, Human, Pair 19; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D010375:Pedigree; D011247:Pregnancy; D014178:Translocation, Genetic