[Inhibition of microsomal oxidation by o-benzoquinone derivatives].
It was found that o-benzoquinone derivatives inhibit the hydroxylation of aniline without any appreciable influence on the spectral changes which are due to cytochrome P-450 binding to the substrate. A comparative kinetic study of inhibition of aniline hydroxylation and NADPH-dependent reduction of o-benzoquinones in liver microsomes revealed that the inhibition is due to the ability of these compounds to shunt microsomal electron transport pathways.
D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D016227:Benzoquinones; D065607:Cytochrome P-450 Enzyme Inhibitors; D004579:Electron Transport; D006900:Hydroxylation; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D010084:Oxidation-Reduction; D011809:Quinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000814:Aniline Compounds; D016227:Benzoquinones; D065607:Cytochrome P-450 Enzyme Inhibitors; D011809:Quinones; C023650:aniline; C025225:2-benzoquinone
Ingibirovanie mikrosomal'nogo okisleniia proizvodnymi o-benzokhinona.