title: [Coronary thrombolysis after intracoronary and intravenous administration of streptokinase to myocardial infarct patients].
abstract: Coronary thrombolysis by intracoronary and intravenous streptokinase (SK) is reported in myocardial infarction patients. Forty-two patients were examined within the first 6 hours of infarction: they were subjected to coronary-angiography on admission and 24 hours later, and their plasma fibrinogen levels were measured repeatedly for 2 days. SK administration was intracoronary in 24 patients and intravenous in 18. Rapid intravenous SK injection was not inferior to intracoronary administration in terms of efficiency. Although coronary reperfusion takes a somewhat longer time in cases of intravenous SK treatment, its technical simplicity and relative safety, as well as the fact that it can be started early suggest that it is a promising method of treatment for myocardial infarction.
mesh_terms: D000328:Adult; D000368:Aged; D003331:Coronary Vessels; D005340:Fibrinogen / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D013300:Streptokinase / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D005340:Fibrinogen; D013300:Streptokinase
vernacular_title: Koronarnyĭ trombolizis pri vnutrikoronarnom i vnutrivennom vvedenii streptokinazy u bol'nykh infarktom miokarda.