title: [Hemodynamic effects of intranasal nifedipine during clamping of the abdominal aorta].
abstract: The haemodynamic changes due to cross-clamping of the abdominal aorta below the renal arteries were studied in ten patients. Anaesthesia was induced with thiopentone and maintained with fentanyl and vecuronium and inhalation of 60% nitrous oxide in oxygen. At the fifth minute, clamping increased mean arterial pressure (Pa) by 11%, systemic vascular resistance (Rsa) by 26% and decreased cardiac output (CO) by 20%. Nifedipine was administered intranasally at this time. Heart rate remained unchanged; mean pulmonary arterial and mean pulmonary wedge pressures were slightly decreased. Pa and Rsa fell to significantly lower levels between the fifth and fifteenth minutes (24 and 43% respectively). Although CO increased by 28%, this was not significant. The administration of intranasal nifedipine during anaesthesia was well tolerated. This study demonstrated that intranasal nifedipine prevented adverse haemodynamic effects of cross-clamping of the aorta below the renal arteries.
mesh_terms: D000281:Administration, Intranasal; D000768:Anesthesia, General; D001012:Aorta, Abdominal / Q000601:surgery*; D003250:Constriction; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D009543:Nifedipine
vernacular_title: Effets hémodynamiques de la nifédipine utilisée par voie nasale au cours du clampage de l'aorte abdominale.