[Additional pathway of the metabolic activation of N-nitrosodiethylamine in the rat liver].
A cytosolic enzyme, aldehyde oxidase (AO), was shown to be involved in metabolic activation of carcinogenic diethylamine (DENA). DENA was reduced to corresponding hydrazines by AO in the presence of benzaldehyde. Products of DENA reduction by AO possessed mutagenic activity for Salmonella typhimurium TA 1950. Pretreatment of rats by antioxidant butylhydroxytoluene had no effect on this process of DNA bioactivation.
D042931:Aldehyde Oxidase; D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D000818:Animals; D001711:Biotransformation; D004052:Diethylnitrosamine / Q000378:metabolism* / Q000633:toxicity; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D009153:Mutagens; D004052:Diethylnitrosamine; D000445:Aldehyde Oxidoreductases; D042931:Aldehyde Oxidase
Dopolnitel'nyĭ put' metabolicheskoĭ aktivatsii N-nitrozodiétilaminav pecheni krys.