Evaluation of ivermectin paste in the treatment of ponies for Parascaris equorum infections.
Twenty ponies less than 18 months of age and infected with Parascaris equorum were treated with either 0.2 mg of ivermectin/kg of body weight (n = 10) or a placebo (n = 10; controls). Five control and 5 ivermectin-treated ponies were euthanatized 14 and 35 days after treatment, respectively. At necropsy, the small intestinal contents, lungs, and liver were examined for larvae and/or adult P equorum. Significantly (P less than 0.02) higher mean total numbers of P equorum were found in the small intestinal contents of the controls on day 14 (51) and on day 35 (21) than in the ivermectin-treated ponies on days 14 (0) and 35 (3). The efficacy of ivermectin in removing adult and intestinal larvae of P equorum at 14 days after treatment was 100%. The efficacies of ivermectin in removing adults and intestinal larvae of P equorum at 35 days after treatment were 100% and 76.9%, respectively. Gross examination of liver and lung tissues revealed damage as a result of P equorum infections in all ponies. The Baermann technique used on liver and lung tissues did not yield any P equorum larvae. Adverse reactions attributable to treatment were not observed.
D000818:Animals; D001199:Ascaridoidea; D006734:Horse Diseases / Q000188:drug therapy / Q000469:parasitology*; D006736:Horses; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D007421:Intestine, Small / Q000469:parasitology*; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D009824:Ointments
D009824:Ointments; D007559:Ivermectin