title: Some effects of prolonged treatment with nicardipine in chronic bronchial asthma.
abstract: A study was carried out in 10 patients with chronic non-severe asthma to investigate the effects of prolonged treatment with the calcium blocker, nicardipine. Patients received 60 mg nicardipine daily for 3 months. Measurements were taken before and after treatment of FEV1, PaO2 and PD20 his. The results showed no statistically significant effect on FEV1. Although there was a statistically significant decrease in PaO2 this was not important clinically. There was a statistically significant increase in PD20 his, demonstrating the protective effect of nicardipine on histamine-induced bronchoconstriction. Breathlessness was reduced in 70% of the patients and the drug was well tolerated throughout the study.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D004341:Drug Evaluation; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000008:administration & dosage / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D013997:Time Factors
chemical_list: D009529:Nicardipine; D010100:Oxygen