Gonadotoxicity and kinetics of dibromochloropropane in male rats.
Adult male rats were injected with [3H]dibromochloropropane dissolved in dimethylsulfoxide containing about 10 X 10(6) dpm. Blood from the tail and 24-h urine samples were collected up to 2 days post-injection. Tissue samples were further taken from the kidneys, liver, spleen, adrenals, epididymis, seminal vesicles and testes 7 h and 7 days post-injection. The results demonstrate that there is no preference in labelling of the testes compared with other organs, and the kidney and liver may have an important role in the elimination of DBCP.
D000818:Animals; D007700:Kinetics; D008297:Male; D011407:Propane / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D014018:Tissue Distribution; D014316:Tritium
D014316:Tritium; C007318:1,2-dibromo-3-chloropropane; D011407:Propane