Sister-chromatid exchange in spleenic lymphocytes of mice after exposure to nifurtimox or benznidazole.
The induction of sister-chromatid exchange (SCE) was analyzed in spleenic lymphocytes of mouse after exposure to nifurtimox (NFX) or benznidazole (BZ). Lymphocytes from Swiss mice treated "in vivo" with 1200 and 2000 mg/kg NFX (p.o.) and then incubated "in vitro" with bromo-2'-deoxyuridine showed an increased frequency of SCE. No significant differences were observed in mice treated with 2000 mg/kg BZ (p.o.). The present and previous results obtained in this and other laboratories suggest that the effects observed should warn against the potential risk of NFX treatment in humans receiving this chemotherapeutic agent as a treatment for Chagas' disease.
D000818:Animals; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009547:Nifurtimox / Q000494:pharmacology*; D009581:Nitrofurans / Q000494:pharmacology*; D009593:Nitroimidazoles / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013154:Spleen / Q000166:cytology
D009581:Nitrofurans; D009593:Nitroimidazoles; D009547:Nifurtimox; C009999:benzonidazole