Effects of two organophosphorus insecticides on some biochemical constituents in the nervous system and liver of rabbits.
Male Baladi rabbits were acutely and sub-chronically intoxicated with cyanofenphos and profenophos. The levels of cholesterol, triglycerides, B-lipoproteins and total proteins were determined in the serum, brain, spinal cord and sciatic nerve of rabbits. Moreover, the activities of alkaline phosphatase, acid phosphatase and glutamic-pyruvic transaminase were determined in the liver of the animals. The whole studies revealed that the biochemical constituents were highly affected by the tested insecticides. Also, the liver function suffered from adverse effects of the tested insecticides.
D000284:Administration, Oral; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009498:Neurotoxins / Q000008:administration & dosage / Q000633:toxicity*; D063086:Organothiophosphates / Q000008:administration & dosage / Q000633:toxicity*; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D013116:Spinal Cord / Q000187:drug effects* / Q000378:metabolism; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D001798:Blood Proteins; D008055:Lipids; D008077:Lipoproteins, LDL; D009419:Nerve Tissue Proteins; D009498:Neurotoxins; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; D014280:Triglycerides; C002488:cyanophenphos; C024273:profenofos; D002784:Cholesterol