[Effect of thiamine and its antimetabolite oxythiamine on the proliferative activity of carcinosarcoma Walker 256 cells].
The microscopic studies of tumours from rats injected with thiamine at a dose of 20 mg/kg for 5 days have shown that sites of hemorrhages and necrosis are considerably more extensive than in tumours of control animals. Injections of the same doses of oxythiamine increase the rate of pathologic mitoses in tumour cells and decrease the tumour weight by 45%, limit the synthesis of thiamine diphosphate and inhibit the transketolase activity in tissues.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D005260:Female; D010119:Oxythiamine / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D013831:Thiamine / Q000378:metabolism / Q000494:pharmacology*; D013835:Thiamine Pyrophosphate / Q000097:blood / Q000378:metabolism; D013844:Thiazoles / Q000494:pharmacology*; D014174:Transketolase / Q000097:blood / Q000378:metabolism
D013844:Thiazoles; D010119:Oxythiamine; D014174:Transketolase; D013835:Thiamine Pyrophosphate; D013831:Thiamine
Vliianie tiamina i ego antimetabolita oksitiamina na proliferatsiiu kletok kartsinosarkomy Uoker 256.