In vivo effect of indobufen and ticlopidine hydrochloride on aortic endothelial integrity of normo- or hyper-cholesterolemic rats.
Rats fed a normo- or hyper-cholesterolic diet were treated for 7 days with indobufen or ticlopidine hydrochloride (Ticl.HCl) orally, 20 mg/kg/day. At the end of treatment, the animals were perfused in vivo to fix the cell and to dye the intracellular junctions of the endothelial reticulum of the arterial wall. The integrity of the aortic endothelial layer was evaluated microscopically. Rats fed a normo- or hyper-cholesterolic diet, treated with indobufen, did not differ from the control group as regards the parameters in question. The animals treated with Ticl.HCl presented a reticulo-endothelial injury when fed a normo-lipidic diet and smooth muscle cell infiltration, an indicator of more advanced lesion, when fed a hypercholesterolic diet.
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology; D004727:Endothelium / Q000187:drug effects / Q000473:pathology; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000473:pathology; D054833:Isoindoles; D008297:Male; D010654:Phenylbutyrates / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D013988:Ticlopidine / Q000494:pharmacology*
D054833:Isoindoles; D010654:Phenylbutyrates; C020371:indobufen; D013988:Ticlopidine