[Vitamin A status and the carcinogenic action of N-nitrosobenzyl methylamine on the esophagus in the rat].
A state of pure vitamin A deficiency, without any clinical manifestations, rapidly induces a stimulation of ornithine decarboxylase (ODC) activity and some oesophageal mucosal abnormalities (hyperkeratosis, dyskeratosis, cytonuclear abnormalities) in rats treated with N-nitrosobenzylmethylamine (NBMA). Retinol deficient rats fed with retinoïc acid (all-trans) show a mucosal ODC induction, but no morphological lesion. The association of retinoïc acid + retinol, as does retinol alone, prevents simultaneously histological lesions and enzymatic induction. In the liver of vitamin A deficient rats treated with NBMA, a stimulation of the ODC system, without any macroscopical lesions, has been observed.
D000818:Animals; D004128:Dimethylnitrosamine / Q000009:adverse effects / Q000031:analogs & derivatives*; D004790:Enzyme Induction / Q000187:drug effects; D004938:Esophageal Neoplasms / Q000139:chemically induced*; D007642:Keratosis / Q000209:etiology; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009955:Ornithine Decarboxylase / Q000378:metabolism; D051381:Rats; D014212:Tretinoin / Q000008:administration & dosage / Q000494:pharmacology; D014801:Vitamin A / Q000008:administration & dosage / Q000494:pharmacology; D014802:Vitamin A Deficiency / Q000188:drug therapy*
D014801:Vitamin A; D014212:Tretinoin; C014707:nitrosobenzylmethylamine; D009955:Ornithine Decarboxylase; D004128:Dimethylnitrosamine
Statut vitaminique A et action cancérigène oesophagienne de la N-nitrosobenzylméthylamine chez le rat.