Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats.
Congenitally jaundiced (jj) Gunn rats had a greater hepatic microsomal content of a cytochrome P-450 isoenzyme, P-450c, than did the non-jaundiced (Jj) rats. No differences in content of P-450b, P-450d and pregnenolone-16 alpha-carbonitrile-induced (PCN) P-450 were found between jj and Jj rats. This is the first demonstration of a constitutive increase in a specific cytochrome P-450 isoenzyme in association with a genetic defect.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005260:Female; D007122:Immunoelectrophoresis; D007527:Isoenzymes / Q000378:metabolism*; D007565:Jaundice / Q000151:congenital / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology*; D011863:Radioimmunoassay; D051381:Rats; D011911:Rats, Gunn
D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System