Comparison of some properties of rubidomycine and its four derivatives.
In the experiments performed on Albino-Swiss mice and Wistar rats it was found that newly synthesized anthracyclines were less toxic and possessed similar pharmacological properties as rubidomycine. Only in some tests their activity was weaker or sometimes different.
D000698:Analgesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000633:toxicity; D005106:Exploratory Behavior / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010146:Pain / Q000503:physiopathology; D010528:Peristalsis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D012684:Sensory Thresholds; D013329:Structure-Activity Relationship
D003630:Daunorubicin