title: Partitioning the respiratory effects of airway citric acid and normal saline in lambs.
abstract: Aspiration is common in the intubated human neonate. Thus, the ventilatory and blood gas responses to citric acid and saline instillation into different airway sites were studied in ten awake, unanesthetised lambs, breathing spontaneously via a tracheostomy tube. With a system of balloons, 1 ml of saline or citric acid was placed selectively into the midtrachea, the laryngeal area, or the lower trachea (lower tr). Changes in minute ventilation (VE), after a 30 sec baseline period, were measured 30 sec and 1 and 2 min after the challenge. Arterial blood gas changes were measured at 30 sec and 2 min. Major increases in VE were seen only when saline or citric acid was instilled into the lower tr, the citric acid responses exceeding saline ones. The arterial oxygen tension (PaO2) fell after lower tr saline, whereas the arterial CO2 tension (PaCO2) fell with midtracheal saline instillation. A rise in pH and a fall in PaCO2 accompanied citric acid given into the lower tr. An initial rise in PaO2 after citric acid into the lower tr was followed by a return to baseline despite hyperventilation. The ventilatory and blood gas changes with saline and citric acid depend on the site of airway instillation.
mesh_terms: D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D002951:Citrates / Q000633:toxicity; D019343:Citric Acid; D007830:Larynx / Q000187:drug effects; D011015:Pneumonia, Aspiration / Q000139:chemically induced / Q000503:physiopathology*; D011659:Pulmonary Gas Exchange; D012756:Sheep; D012965:Sodium Chloride / Q000633:toxicity; D014132:Trachea / Q000187:drug effects
chemical_list: D002951:Citrates; D019343:Citric Acid; D012965:Sodium Chloride