The effect of famotidine, a new H2 receptor antagonist, on antipyrine clearance in healthy volunteers.
The salivary clearance of Antipyrine (15 mg/kg p.o.) has been measured in nine healthy volunteers (5 males, 4 females) before and after 7 days treatment with Famotidine (40 mg/day at bedtime). Samples of saliva were collected twenty four hours after each dose of Antipyrine. The post-treatment sample was taken 12 hours after the last dose of Famotidine. The clearance of Antipyrine was measured by Gas-Liquid Chromatography using the simplified formula proposed by Dossing et al. (1982). After treatment with Famotidine, a slight but significant (p less than 0.01) increase of Antipyrine clearance was observed in eight out of the nine subjects, suggesting some interference of Famotidine with Antipyrine metabolism.
D000328:Adult; D000983:Antipyrine / Q000378:metabolism*; D015738:Famotidine; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D012463:Saliva / Q000378:metabolism; D013844:Thiazoles / Q000494:pharmacology*
D011970:Receptors, Histamine H2; D013844:Thiazoles; D015738:Famotidine; D000983:Antipyrine