24-h catecholamine excretion: relationships with age and weight.
24-hour urines were obtained from groups of volunteer subjects recruited from populations in the UK, USA, Nigeria and the South Pacific. Urines were collected during the course of normal daily activities. HPLC/electrochemical detection was used to measure concentrations of adrenaline and noradrenaline in each urine. Calculated 24-h output of catecholamines was tested for significant linear regression relationships with age, weight and 24-h urine volume in each population. Noradrenaline excretion tended to be positively related to age and to body wt. Adrenaline excretion tended to show little or no relationship with either age or body wt. Relationships based on catecholamine excretion/U creatinine were notably different to those based on absolute catecholamine excretion. Differences were observed in the nature and strength of the relationships in the different populations, indicating the likely importance of interactions with other factors.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000652:urine*; D001213:Asian; D001835:Body Weight; D002940:Circadian Rhythm; D003404:Creatinine / Q000652:urine; D004739:England; D004837:Epinephrine / Q000652:urine*; D005260:Female; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D009638:Norepinephrine / Q000652:urine*; D010139:Pacific Islands
D003404:Creatinine; D009638:Norepinephrine; D004837:Epinephrine