Effect of acute administration of bromocriptine on isoproterenol- and angiotensin II-induced water intake in estrogen-treated rats.
Chronic administration of an estrogenic agent is well known to attenuate the drinking response of rats to treatment with a variety of dipsogenic agents, and to increase plasma concentration of prolactin. Treatment with prolactin is also known to reduce the drinking response to administration of the dipsogenic agent, isoproterenol. Hence, a possibility existed that the antidipsogenic effect of chronic treatment with estrogen was mediated by an increased plasma prolactin concentration. Since bromocriptine, a dopaminergic agonist, is known to reduce plasma prolactin concentration in estrogen-treated rats, it was administered (1.0 mg/kg, IP) 15 min prior to treatment with either isoproterenol (25 micrograms/kg, SC) or angiotensin II (200 micrograms/kg, SC). The results suggest that the antidipsogenic effect of chronic treatment of rats with estradiol benzoate (30.4 and 45.7 micrograms/kg/day) can be reversed, at least partially, by acute administration of bromocriptine.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D004965:Estrogen Antagonists / Q000494:pharmacology; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D004965:Estrogen Antagonists; D000804:Angiotensin II; D001971:Bromocriptine; D004958:Estradiol; D007545:Isoproterenol