[Cytoprotection of gastric mucosa induced by tripotassium-dicitrato bismuthate against ethanol stress. Dependent mechanisms of sulfhydryl, dopaminergic and endogenous prostaglandin].
In groups of white Wistar rats, the cytoprotective effect induced by TDB on the gastric mucosa against the ethanol injury, was studied; where macroscopic protection and histologic cytoprotection in gastric corpus was found, and no in antrum mucosa. The cytoprotective mechanism give by TDB, were studied by the test of Indomethacin, Cl2Hg, Domperidone, Chlorpromazine and Acetazolamide, where each drug was given as pretreatment. Was conclude that TDB give gastric cytoprotection by the mechanism of the nonprotein sulfhydryl, by to be one peripheral agonist of the neuronal dopamine receptors, by increase of endogenous prostaglandin, by little increment of cAMP and no participate the gastric bicarbonate secretion.
D000086:Acetazolamide / Q000494:pharmacology; D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology; D004294:Domperidone / Q000494:pharmacology; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008627:Mercuric Chloride / Q000494:pharmacology; D009336:Necrosis; D009942:Organometallic Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009942:Organometallic Compounds; D000431:Ethanol; D008627:Mercuric Chloride; D004294:Domperidone; C002791:bismuth tripotassium dicitrate; D000086:Acetazolamide; D002746:Chlorpromazine; D007213:Indomethacin
Citoprotección de la mucosa gástrica inducida por T.D.B. ante la agresión del etanol. Mecanismos sulfidrilo, dopaminérgico y prostaglandino endógeno dependientes.