Study on pulmonary, prostatic and renal (medulla and cortex) distribution of sagamicin at different time intervals.
In order to assess the therapeutic activity of an antibiotic, not only its serum kinetics but also its kinetics in the peripheral tissues must be determined, thus evaluating the specific power of penetration of the drug. Sagamicin is an aminoglycosidic basic antibiotic closely related to gentamicin and its penetration rate into lungs, kidney and prostate, together with its serum concentrations time-course, were investigated. The findings obtained showed that this antibiotic attained a good distribution in the peripheral tissues, where it easily reached therapeutic levels.
D000617:Aminoglycosides / Q000097:blood / Q000378:metabolism / Q000652:urine; D000900:Anti-Bacterial Agents / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005839:Gentamicins; D006207:Half-Life; D006801:Humans; D007273:Injections, Intramuscular; D007672:Kidney Cortex / Q000378:metabolism*; D007679:Kidney Medulla / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008297:Male; D011467:Prostate / Q000378:metabolism*; D013997:Time Factors
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; C037545:micronomicin