[Results of a study of new preparations of inactivated whole-virion influenza vaccines for the protection of children in the USSR].
The safety, reactogenic properties and antigenic potency of inactivated whole-virion influenza vaccines produced in the USSR were studied on 1,117 schoolchildren in limited coded clinico-immunological observations. Inactivated chromatographic influenza vaccine obtained from strain A/Texas/1/77 (H3N2) and a variant of this vaccine, developed specially for children and obtained from strains A/Texas/1/77 and B/Leningrad/76, were used for immunization. Both preparations were introduced intradermally in a single injection in a volume of 0.1-0.2 ml by means of bi-3 jet injector. The content of hemagglutinin in this volume varied from 3.0 to 8.0 micrograms. Clinico-laboratory investigations demonstrated the safety of mono- and bivalent inactivated whole-virion influenza vaccine administered intradermally in a single injection to children of school age. The vaccines showed low reactogenicity and high antigenic potency in children aged 7-10 and 11-14 years, and the optimal doses of the preparations were selected for children of different age groups. The distinct prophylactic effectiveness of inactivated chemical chromatographic influenza vaccines in children aged 11-14 years was revealed 11 months after immunization, the index of immunological effectiveness being 1.7.
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D004196:Disease Outbreaks / Q000517:prevention & control; D004341:Drug Evaluation; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D013997:Time Factors; D014586:USSR; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology; D014771:Virion / Q000276:immunology*
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated
Itogi izucheniia novykh preparatov grippoznykh inaktivirionnykh vaktsin dlia zashchity deteĭ v SSSR.