Age-related changes in neurotensin content and receptors in various rat brain areas.
Neurotensin immunoreactivity (NT-IR) is significantly reduced in striatum, nucleus accumbens and hippocampus but not in frontal cortex, hypothalamus and septum of 24-month-old male Sprague Dawley rats. Neurotensin binding in cortex, striatum, hypothalamus and hippocampus shows a rather uniform decline with age. The changes in NT-IR content in striatum and nucleus accumbens are of particular interest in view of the existence of a functional relationship between dopamine and neurotensin.
D000375:Aging / Q000502:physiology*; D000818:Animals; D001923:Brain Chemistry; D003342:Corpus Striatum / Q000032:analysis; D004298:Dopamine / Q000502:physiology; D005625:Frontal Lobe / Q000032:analysis; D006624:Hippocampus / Q000032:analysis; D007031:Hypothalamus / Q000032:analysis; D008297:Male; D009496:Neurotensin / Q000032:analysis* / Q000276:immunology / Q000378:metabolism; D009714:Nucleus Accumbens / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D009496:Neurotensin; D004298:Dopamine