title: [The influence of method/apparatus conditions on the in vitro liberation of drugs from suppositories].
abstract: The examination and evaluation of three experimental designs for the registration of the in-vitro availability of drugs from suppositories--evaluated by using four suppository preparations--showed the special aptitude of a modified model with a large membrane. This model which considers the spreading of the suppository under load, enables one to characterize the in-vitro drug release even for preparations with a low rate of liberation and it provides correct references to bioavailability.
mesh_terms: D000983:Antipyrine / Q000031:analogs & derivatives; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation; D004364:Pharmaceutical Preparations; D013488:Suppositories; D014192:Trapidil
chemical_list: D004364:Pharmaceutical Preparations; D013488:Suppositories; D014192:Trapidil; C009077:propyphenazone; D000983:Antipyrine
vernacular_title: Zum Einfluss methodisch-apparativer Bedingungen auf die in-vitro-Liberation von Arzneistoffen aus Suppositorien.