[IgG, IgM, IgA, secretory IgA and the complement components C3, C4 and C9 in the large intestine in nonspecific ulcerative colitis and Crohn disease].
The immunohistological study of the large intestines excised from 20 patients with ulcerous colitis and Crohn's disease was made with the use of the indirect immunofluorescence test. A considerable increase in the number of IgG immunocytes has been noted in the lamina propria of the mucous membrane, especially in infiltrations around ulcers. In cases of a highly active inflammatory process accompanied by the pronounced destruction of the epithelium, IgG and C3, C4, C9 were detected in the epithelium of crypts and in blood vessels of the mucous membrane and the submucosa. One-third of the patients showed a decrease in the number of crypts with secretory and serum IgA. The authors suggest that immune complexes take part in maintaining the chronic inflammatory process.
D003093:Colitis, Ulcerative / Q000276:immunology*; D003165:Complement System Proteins / Q000032:analysis*; D003424:Crohn Disease / Q000276:immunology*; D004848:Epithelium / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D007159:Immunologic Tests; D007413:Intestinal Mucosa / Q000098:blood supply / Q000276:immunology; D007420:Intestine, Large / Q000276:immunology*
D007136:Immunoglobulins; D003165:Complement System Proteins
IgG, IgM, IgA, sekretornyĭ IgA i komponenty komplementa C3, C4, C9 v tolstoĭ kishke pri nespetsificheskom iazvennom kolite i bolezni Krona.