Differential effects of cadmium on cytosolic and mitochondrial glutathione levels in the rat heart.
In rats fed a low-selenium diet, cytosolic GSH levels in the heart were significantly elevated when compared to rats fed a selenium-supplemented diet. Similar results were obtained in cardiac cytosol from rats treated with either parenteral or dietary Cd. Mitochondrial GSH was not affected by cadmium in selenium-deficient rats. However, significant elevations of mitochondrial GSH were seen in cadmium-treated rats fed either 0.1 or 0.5 ppm selenium. The alterations in cytosolic GSH levels correlate with reductions in GSH-Px activity reported earlier [(1987) Toxicol. Appl. Pharmacol. 87, in press]. However, levels of mitochondrial GSH did not correlate with GSH-Px activity.
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D003600:Cytosol / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000008:administration & dosage
D002104:Cadmium; D005979:Glutathione Peroxidase; D005978:Glutathione; D012643:Selenium