Effect of lidocaine treatment on acute spinal cord injury.
The effect of continuous infusion of lidocaine on acute spinal cord trauma in cats was studied. Intravenous and subarachnoid administration of lidocaine did not alter generation and conduction of the spinal evoked responses (SERs) in intact animals. The cortical somatosensory evoked responses and SERs were abolished after weight drop injuries of 120 and 400 g-cm. No return of the evoked responses occurred within 4 hours after trauma in either the lidocaine- or the saline-treated groups. Loss of SERs and appearance of an evoked injury potential were sensitive determinants of spinal cord injury. We concluded that lidocaine treatment did not facilitate the return of spinal cord function in this model of acute spinal cord injury.
D000818:Animals; D002415:Cats; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D008012:Lidocaine / Q000627:therapeutic use*; D009431:Neural Conduction / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000503:physiopathology
D008012:Lidocaine