Effect of Glyzophrol on fertility of female black rats (Rattus rattus).
Mild degree of fibrosis, dilatation of blood vessels, haemorrhagic reactions in a few places, granulosa cells in stroma and no effect on maturation process of follicles were observed in ovary of 20 mg/kg of Glyzophrol treated rats. After 60 mg/kg of Glyzophrol treatment, ovary revealed reduction in number of follicles, degenerative changes in existing follicles, frequent proliferation of granulosa cells and fibrosis in stroma along with karyorrhexis, karyolysis and pyknosis in nuclei. Haemorrhage and dilated blood vessels in stroma were well marked, suggesting that ovarian vasculature was affected by glyzophrol. Ovary exhibited increase in activity of acid phosphatase after Glyzophrol treatment. Intense alkaline phosphatase activity was observed in entire ovarian tissue after Glyzophrol treatment.
D000135:Acid Phosphatase / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D002066:Busulfan / Q000494:pharmacology*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D009115:Muridae; D010053:Ovary / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D010572:Pest Control, Biological; D051381:Rats; D012375:Rodent Control / Q000379:methods*
D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D002066:Busulfan