Influence of ketanserin (serotonin antagonist) on bladder and urethral function.
As it is known that serotonin or 5-hydroxytryptamine can enhance bladder activity, we studied urodynamically the effect of ketanserin, a serotonin antagonist, in 17 patients, in the hope that this drug might be useful in treating unstable bladders. However, a relaxant effect on bladder contractility could not be demonstrated. On the contrary, a significant decrease of the urethral pressure was observed, suggesting that ketanserin might still have a possible role in promotion of bladder emptying. The relaxant effect on the urethra suggests some alpha-sympathicolytic activity of ketanserin.
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007650:Ketanserin / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000494:pharmacology; D014521:Urethra / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects*; D001745:Urinary Bladder Diseases / Q000188:drug therapy
D012701:Serotonin; D007650:Ketanserin