title: [Severe laryngeal dysplasia and synthetic retinoids].
abstract: Nine patients with "severe" laryngeal dysplasia as shown by multiple microbiopsies during laryngoscopy were treated with a synthetic derivative of retinol (Etretinate 0.5 to 1 mg/kg/day) over one or two months. Follow up histology after 8 to 18 months surveillance showed histologic improvement with respect to dyskeratosis, atypical cells and to a lesser extent epithelial hyperplasia. The use of synthetic vitamin A derivatives for "severe" laryngeal dysplasia is discussed.
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005050:Etretinate / Q000627:therapeutic use*; D006801:Humans; D006965:Hyperplasia; D007830:Larynx / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000188:drug therapy / Q000473:pathology
chemical_list: D005050:Etretinate
vernacular_title: Dysplasies laryngées sévères et rétinoïde de synthèse.