title: Hypothalamo-hypophysial blood flow: a novel control mechanism in pituitary function?
abstract: The flow rate of portal plasma was measured during hypothalamo-hypophysial portal sampling in the rat using a modified Worthington-Fink technique. In rats rendered hypothyroid with propylthiouracil, there was a significant 140% increase in portal plasma flow. Median eminence stimulation also increased portal plasma flow by 41%. Orchidectomy and adrenalectomy had no effects on plasma flow. Modification of flow rate in the hypothalamo-hypophysial vascular bed may represent a further mechanism involved in the control of pituitary function.
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D007030:Hypothalamo-Hypophyseal System / Q000098:blood supply*; D007037:Hypothyroidism / Q000503:physiopathology*; D008297:Male; D009919:Orchiectomy; D010902:Pituitary Gland / Q000503:physiopathology; D011441:Propylthiouracil; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow
chemical_list: D011441:Propylthiouracil