Elimination of and heart rate response to atropine in the elderly are independent of sex.
Sex-related changes in the pharmacokinetics and pharmacodynamics (heart rate) of atropine were studied in female (n = 9) and male (n = 9) elderly patients after a single 0.02 mg/kg i.v. injection of the drug at the beginning of a combination anaesthesia. No significant differences were found between the sexes, which indicates that there are no sex-related alterations in the response to this anticholinergic agent.
D000368:Aged; D000375:Aging; D001285:Atropine / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D008297:Male; D011863:Radioimmunoassay; D012737:Sex Factors
D001285:Atropine