Acetylcholinesterase activity rises in rat cerebrospinal fluid post-ictally; effect of a substantia nigra lesion on this rise and on seizure threshold.
The activity of acetylcholinesterase (AChE) in the cerebrospinal fluid (CSF) of rats increased by 53% following an electroconvulsive shock (ECS) while non-specific cholinesterase (nsChE) activity was unchanged. A flurothyl-induced seizure failed to elicit a change in the AChE activity of CSF. A bilateral lesion of the substantia nigra pars reticulata abolished the rise in AChE activity in the CSF but did not diminish the increase of seizure threshold which follows a convulsion. These data suggest that AChE is released from the substantia nigra following a seizure but indicate that the change is not associated with the rise in seizure threshold which occurs.
D000110:Acetylcholinesterase / Q000134:cerebrospinal fluid*; D000818:Animals; D002946:Cisterna Magna / Q000503:physiopathology; D004597:Electroshock; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000134:cerebrospinal fluid / Q000503:physiopathology*; D013378:Substantia Nigra / Q000033:anatomy & histology / Q000502:physiology*
D000110:Acetylcholinesterase