title: Effect of added dietary cobalt on metabolism and distribution of radioactive selenium and stable minerals.
abstract: Retention of 75Se following a single oral dose and stable Co, Cu, Zn, and Mg were determined in tissues of calves fed a diet containing 0, 10, or 40 ppm supplemental Co for 21 d. Concentrations of 75Se in tissue were numerically higher with 10 ppm Co than with the other two diets, but the effect was significant only in small intestine tissues of calves fed 40 ppm Co. Dietary Co did not affect fecal 75Se. Average total fecal 75Se excretion was 53, 48, and 51% of the dose over 6 d in calves fed 0, 10, and 40 ppm added Co. Concentrations of Co in tissues increased with increased supplementation. Dietary Co did not significantly affect growth, feed intake, tissue Zn, tissue Cu, blood hemoglobin, packed cell volume, plasma alkaline phosphatase, or plasma glutamic oxaloacetic transaminase. Magnesium in heart and skeletal muscle was increased in calves fed 40 ppm Co. Although high amounts of added dietary Co had some influence on metabolism of Se, the magnitude and extent of the effects appeared to be too small to be of practical concern.
mesh_terms: D000818:Animals; D002417:Cattle / Q000378:metabolism*; D003035:Cobalt / Q000008:administration & dosage / Q000494:pharmacology*; D003300:Copper / Q000378:metabolism*; D004032:Diet; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D012643:Selenium / Q000378:metabolism*; D014018:Tissue Distribution; D015032:Zinc / Q000378:metabolism*
chemical_list: D003035:Cobalt; D003300:Copper; D012643:Selenium; D008274:Magnesium; D015032:Zinc