Fluorouracil (5-FU) induced acute immune haemolytic anaemia.
A female patient on Fluorouracil (5-FU) therapy for rectal carcinoma developed acute intravascular haemolysis with her fifteenth drug injection; a similar episode occurred later after a controlled challenge with the drug. A 5-FU-dependent complement-activating IgM antibody, which reacted with RBC in an indirect antiglobulin test, was detected in her serum. The antibody did not react with cord RBC, but a blood group specificity could not be determined. An excess of 5-FU in the indirect antiglobulin tests resulted in inhibition of these reactions.
D000208:Acute Disease; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000139:chemically induced* / Q000276:immunology; D003298:Coombs Test; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008875:Middle Aged
D007075:Immunoglobulin M; D005472:Fluorouracil