[Comparative characteristics of the composition and degree of sulfation of glycosaminoglycans in resting and actively proliferating tissues].
A comparative study of the composition and degree of sulfation of glycosaminoglycans (GAG) in proteoglycans isolated from normal animal tissues and from actively proliferating embryonic, tumour and regenerating tissues was carried out. Significant differences in the ratios of various types of sulfated GAG were revealed. The relative content of chondroitin sulfate AC in actively proliferating tissues was considerably increased. It was found that all types of sulfated GAG in actively proliferating tissues, with the exception of regenerating tissue, are characterized by a lower degree of sulfation as compared to GAG from resting tissues. The experimental results are discussed in terms of the role of proteoglycans in the organization of extracellular matrix and in control of cell proliferation.
D000818:Animals; D002455:Cell Division; D004588:Electrophoresis, Cellulose Acetate; D006025:Glycosaminoglycans / Q000032:analysis*; D008099:Liver / Q000032:analysis / Q000166:cytology; D008114:Liver Neoplasms, Experimental / Q000032:analysis / Q000473:pathology; D008115:Liver Regeneration; D051379:Mice; D008809:Mice, Inbred C3H; D051381:Rats; D011919:Rats, Inbred Strains
D006025:Glycosaminoglycans; C013786:A73025
Sravnitel'naia kharakteristika sostava i stepeni sul'fatirovaniia glikozaminoglikanov pokoiashchikhsia a aktivno proliferiruiushchikh tkaneĭ.