Assay of ambroxol in biological fluids by capillary gas-liquid chromatography.
A sensitive and rapid method for the determination of ambroxol in biological fluids is described. It comprises a single extraction step, derivatization and selective determination with capillary gas-liquid chromatography (in split-mode) and electron-capture detection. The limit of quantification in plasma is ca. 3 ng/ml. The method is applied to the pharmacokinetics of ambroxol in humans.
D000551:Ambroxol / Q000032:analysis* / Q000097:blood / Q000652:urine; D001964:Bromhexine / Q000031:analogs & derivatives*; D002849:Chromatography, Gas; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D007700:Kinetics
D007202:Indicators and Reagents; D000551:Ambroxol; D001964:Bromhexine