Excretion of chloroquine, dapsone and pyrimethamine in human milk.
The concentration of chloroquine (CQ), dapsone (DDS) and pyrimethamine (PYR) in plasma and milk were measured following the coadministration of a single dose of chloroquine and Maloprim to lactating women. The milk to plasma area under the concentration-time curve (AUC) ratio ranged from 1.96 to 4.26 for CQ, 0.22 to 0.45 for DDS and 0.46 to 0.66 for PYR. Assuming a daily milk ingestion of 1 l by the infant, the maximum percentage of the maternal dose for CQ, DDS and PYR in milk was 4.2%, 14.3% and 45.6%, respectively, over a 9 day period.
D000328:Adult; D002738:Chloroquine / Q000097:blood / Q000378:metabolism*; D003622:Dapsone / Q000097:blood / Q000378:metabolism*; D004338:Drug Combinations / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D008288:Malaria / Q000517:prevention & control; D008895:Milk, Human / Q000378:metabolism*; D011247:Pregnancy; D011739:Pyrimethamine / Q000097:blood / Q000378:metabolism*
D004338:Drug Combinations; C001678:Maloprim; D002738:Chloroquine; D003622:Dapsone; D011739:Pyrimethamine