Increased synthesis of poly(ADP-ribose) in isolated liver nuclei from autoimmune NZB/NZW mice.
The synthesis and degradation of poly(ADP-ribose) were investigated in isolated liver nuclei from autoimmune NZB/W mice and four strains of normal mice. Compared to normal mice the maximum levels of incorporation of [3H]NAD into poly(ADP-ribose) were increased about 2-fold in the autoimmune mice. The kinetics of incorporation suggested that this change was due to an increase in the activity of the polymerase rather than a decrease in the level of degradative enzymes. Thus there may be a connection between autoimmunity and poly(ADP-ribose) metabolism.
D000818:Animals; D001327:Autoimmune Diseases / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D005260:Female; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains; D009702:Nucleoside Diphosphate Sugars / Q000096:biosynthesis*; D011064:Poly Adenosine Diphosphate Ribose / Q000096:biosynthesis*
D009702:Nucleoside Diphosphate Sugars; D011064:Poly Adenosine Diphosphate Ribose