Effect of aluminum phosphate on the bioavailability of ranitidine.
The effect of aluminum phosphate on the bioavailability of ranitidine has been investigated in 10 young, healthy volunteers. Following a random cross over design, each subject took at a 1 week interval 150 mg ranitidine alone or with 11 g aluminum phosphate. Plasma and urine ranitidine levels were measured by HPLC. The antacid reduced both the maximum plasma ranitidine concentration by 40% and the area under the curve by 30%. Elimination of ranitidine was not changed. The results indicate that aluminum phosphate significantly diminished the bioavailability of ranitidine.
D000328:Adult; D000535:Aluminum / Q000494:pharmacology*; D017607:Aluminum Compounds; D000863:Antacids / Q000494:pharmacology*; D001682:Biological Availability; D005260:Female; D005782:Gels; D006801:Humans; D007700:Kinetics; D008297:Male; D010710:Phosphates / Q000494:pharmacology*; D011899:Ranitidine / Q000378:metabolism* / Q000652:urine
D017607:Aluminum Compounds; D000863:Antacids; D005782:Gels; D010710:Phosphates; D011899:Ranitidine; D000535:Aluminum; C012714:aluminum phosphate