Efficacy of a substituted methyl benzimidazole carbamate against developing and adult helminth parasites.
The efficacy of a substituted methyl benzimidazole carbamate, methyl 5(6)-[4-N-(2-pyridyl)] piperazino carbamoyl benzimidazole-2-carbamate, was assessed against larval and adult forms of Ancylostoma ceylanicum (hookworm), Nippostrongylus brasiliensis (trichostrongylid), Hymenolepis nana (tapeworm) and Brugia malayi (filariid) in experimentally-infected animals. The compound was found to have high efficacy against the developing stages (L3, L4, L5) of A. ceylanicum in hamsters at a single dose of 12.5 mg kg-1, against larvae of N. brasiliensis at 17.5 mg kg-1 and against cysticercoids of Hymenolepis nana at 100 mg kg-1 daily for 3 days given per os (p.o.) or intraperitoneally (i.p.). All the stages of B. malayi in Mastomys were killed when the compound was given i.p. at a dose of 6.25 mg kg-1 for 5 consecutive days. A dose of 6.25 mg kg-1 eliminated all adult A. ceylanicum from infected hamsters, 100 mg kg-1 resulted in complete removal of Syphacia obvelata adults from 63.6% of infected mice, 25 mg kg-1 X 5 dose eliminated 100% of adult B. malayi from infected Mastomys and a single 50 mg kg-1 dose expelled all H. nana adults from infected rats.
D000722:Ancylostoma / Q000187:drug effects*; D000724:Ancylostomiasis / Q000188:drug therapy / Q000662:veterinary; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D002009:Brugia / Q000187:drug effects*; D002219:Carbamates / Q000494:pharmacology* / Q000627:therapeutic use; D006224:Cricetinae; D005260:Female; D005368:Filariasis / Q000188:drug therapy / Q000662:veterinary; D006925:Hymenolepiasis / Q000188:drug therapy / Q000662:veterinary; D006926:Hymenolepis / Q000187:drug effects*; D007814:Larva / Q000187:drug effects; D008297:Male; D051379:Mice; D009115:Muridae; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary; D009559:Nippostrongylus / Q000187:drug effects*; D051381:Rats
D001562:Benzimidazoles; D002219:Carbamates; C043589:CDRI 81-470