[Analysis and stability of propiverine hydrochloride (Mictonorm)].
In acid, neutral and alkaline solution the hydrolytic degradation of the spasmolytic agent Mictonorm (1) was determined. As degradation products ester- and/or ether fragments (2-5), benzophenone (6) and a compound X (7) were identified. In comparison N-Methylpiperidinyl(4)-benzilate (2) and benzilic acid (3) were also investigated in the isothermal quick-assay test. The test showed that the ether bound in 1 was hydrolyzed before the ester group. The compounds 5-7 are formed also direct from 3.
D001561:Benzilates / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D003460:Crystallization; D004355:Drug Stability; D006868:Hydrolysis; D013056:Spectrophotometry, Ultraviolet
D001561:Benzilates; C015586:propiverine
Zur Analytik und Stabilität von Propiverinhydrochlorid (Mictonorm).