Renal lesions following administration of calcitonin. A consideration on the morphological similarities to IgA nephropathy.
In previous papers angiolysis of mesenteric arteries and mesangiolytic changes of renal arteries following administration of a vast amount of Na2EDTA were reported. In this study the effect of the calcium depressor calcitonin is investigated experimentally in the kidney. Long-term observation over 6 months demonstrates early stages of mesangiolysis in the renal glomeruli, morphological changes of the basement membrane and mesangial cell proliferation. Moreover, paramesangial dense deposits, probably consisting of IgA were visualized. The variable intensities of the lesions in different glomeruli and segments are very similar to those observed in IgA nephropathy.
D000818:Animals; D002116:Calcitonin / Q000633:toxicity*; D005260:Female; D005920:Glomerular Mesangium / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000473:pathology*; D006168:Guinea Pigs; D006996:Hypocalcemia / Q000473:pathology; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008297:Male; D013997:Time Factors
D002116:Calcitonin