High plasma concentrations of desmethylclomipramine after chronic administration of clomipramine to a poor metabolizer.
A patient showed excessive concentrations of desmethylclomipramine after receiving normal daily doses of clomipramine (Anafranil) and the elimination kinetics of the desmethylated metabolite was zero-order/saturable. Investigation showed that she was a poor metabolizer of debrisoquine and that, in addition, she had been treated with allopurinol, an inhibitor of hepatic drug metabolism.
D000493:Allopurinol / Q000009:adverse effects; D002997:Clomipramine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*; D003647:Debrisoquin / Q000378:metabolism; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D006900:Hydroxylation; D007700:Kinetics; D008875:Middle Aged
C012273:desmethylclomipramine; D000493:Allopurinol; D002997:Clomipramine; D003647:Debrisoquin