title: Antibody that recognizes conformations of calmodulin in the serum from patient with chronic active hepatitis.
abstract: According to the effects of Ca++ on the reactivity, anti-calmodulin antibody in the sera of patients with autoimmune chronic active hepatitis was classified into three types, which were tentatively designated as type 1, 2 and 3. Type 1 antibody reacted with calmodulin only in the presence of free Ca++. Binding of type 2 antibody to calmodulin was inhibited by the presence of free Ca++. Type 3 antibody reacted with calmodulin regardless of the presence or absence of free Ca++. Thus the sera contained the populations of the antibody which recognized the different conformations of calmodulin molecule.
mesh_terms: D001323:Autoantibodies / Q000302:isolation & purification*; D002118:Calcium / Q000378:metabolism; D002147:Calmodulin / Q000276:immunology* / Q000378:metabolism; D006521:Hepatitis, Chronic / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007120:Immunochemistry; D011487:Protein Conformation
chemical_list: D001323:Autoantibodies; D002147:Calmodulin; D002118:Calcium