title: Depression: the chronophysiological approach.
abstract: The author discusses the different clinical phenomena which stimulate a chronophysiological approach; he illustrates in particular the role of sleep in depression. He then discusses the alternation between sleep and wakefulness and describes a model that has been proposed to explain its regulation.
mesh_terms: D000339:Affect; D001714:Bipolar Disorder / Q000503:physiopathology; D002909:Chronobiology Phenomena; D003863:Depression / Q000503:physiopathology*; D004569:Electroencephalography; D006801:Humans; D012621:Seasons; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000502:physiology; D014851:Wakefulness / Q000502:physiology