Evidence for a signal peptide at the amino-terminal end of human mitochondrial aldehyde dehydrogenase.
A full-length cDNA clone coding for human mitochondrial aldehyde dehydrogenase (ALDH I) was isolated from a human fetal muscle cDNA library. Sequence analysis revealed structural similarities between the amino-terminal end of ALDH I and other known targeting sequences responsible for protein uptake into the mitochondria.
D000444:Aldehyde Dehydrogenase / Q000032:analysis*; D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis; D006801:Humans; D008928:Mitochondria / Q000201:enzymology*; D021382:Protein Sorting Signals / Q000032:analysis*
D021382:Protein Sorting Signals; D004247:DNA; D000444:Aldehyde Dehydrogenase