Differential effects of chronic partial myelotomies on monoamine levels in cat spinal cord.
The concentrations of 5-hydroxytryptamine (5-HT), norepinephrine (NE) and dopamine (DA) were measured in samples of lumbar and cervical spinal cords from 6 cats with chronic (over 2 months) lesions of the thoracic spinal cord and from 7 unoperated cats. Lesions confined to the dorsal thoracic spinal cord significantly lowered lumbar concentrations of NE, but not 5-HT, compared with control lumbar or matched paired cervical samples. Both NE and 5-HT were significantly reduced by dorsal or ventral lesions that involved tissue ventral to the central canal. Only the largest lesion could be shown to reduce lumbar DA concentration.
D000818:Animals; D002415:Cats; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D009638:Norepinephrine / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism / Q000601:surgery*
D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine