Unit activity in the nucleus triangularis septi of the rat following blood pressure changes or vasoactive peptides, and electrically stimulated blood pressure decreases.
The nucleus Triangularis Septi (TS) of anesthetized rats was studied using iontophoretic application of various vasoactive peptides (vasopressin and angiotensin) to a small number of the cells in this nucleus and blood pressure recordings during electrical stimulation of the nucleus. In the iontophoretic study 83% of the cells investigated were found to be sensitive to iontophoretic application or intracerebroventricular infusion of angiotensin II and vasopressin and that 40% of these cells were sensitive to spontaneous or induced increases of blood pressure. Electrical stimulation of the nucleus produced a reliable and reproducible decrease in blood pressure without any change in heart rate. Therefore the possible role of the TS in blood pressure regulation is discussed.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure; D004558:Electric Stimulation; D004594:Electrophysiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000187:drug effects / Q000502:physiology*; D013356:Subfornical Organ / Q000502:physiology; D014667:Vasopressins / Q000494:pharmacology; D014882:Water-Electrolyte Balance
D014667:Vasopressins; D000804:Angiotensin II