title: Simultaneous vaccination by three living attenuated strains of Brucella, Salmonella and Chlamydia in mice.
abstract: Associations of vaccines for simultaneous administration were successfully developed long ago, in particular in human medicine, although there have been very few attempts to associate living bacterial vaccines. Unfortunately, living vaccines can interact with one another resulting in either a virulent infection or an exclusion of one by the other. Having developed two new low virulence vaccinal strains of Chlamydia psittaci var. ovis and Salmonella abortus ovis for use in veterinary medicine, we studied associations of both and with the Brucella melitensis Rev1 vaccine in mice. There was no interaction between the Chlamydia and the Salmonella vaccines and between the Salmonella and the Brucella vaccines from the point of view of immunogenicity. In contrast, anti-Chlamydia immunity was decreased by about 15-19% when the Chlamydia vaccine was associated with the Brucella vaccine in double or triple association. Surprisingly, the Chlamydia vaccinal strain infection was slightly extended when administered in association. The simultaneous vaccination we tested could be of great interest in veterinary medicine, but special attention must be devoted to anti-Chlamydia immunity and would have to be studied in a ewe model.
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D002004:Brucella Vaccine / Q000276:immunology*; D002006:Brucellosis / Q000276:immunology; D002691:Chlamydophila psittaci / Q000276:immunology*; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D051379:Mice; D009956:Psittacosis / Q000276:immunology; D012475:Salmonella / Q000276:immunology*; D012481:Salmonella Infections, Animal / Q000276:immunology; D013154:Spleen / Q000382:microbiology; D014611:Vaccination; D014613:Vaccines, Attenuated
chemical_list: D001428:Bacterial Vaccines; D002004:Brucella Vaccine; D004338:Drug Combinations; D014613:Vaccines, Attenuated