Why does a sucrose choice reduce the consumption of alcohol in C57BL/6J mice?
To determine why animals reject alcohol when offered palatable solutions of sucrose, male C57BL/6J mice were challenged first with 5% sucrose then with 10% sucrose, while given continuous free-access to alcohol and water. The 5% sucrose dramatically reduced the intake of alcohol and increased the intake of total fluid by an average of 7.3 ml/day. The suppression of alcohol intake could not be attributed to a volumetric ceiling since access to 10% sucrose produced a further large increase in total intake (8.8 ml/day). The results support the interpretation that animals consume alcohol for characteristics it shares with sucrose.
D000428:Alcohol Drinking / Q000502:physiology*; D000818:Animals; D002755:Choice Behavior / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013395:Sucrose
D013395:Sucrose