Eosinophil chemotactic activity in allergic patients during the birch pollen season: the effect of immunotherapy.
Recently, heat-labile eosinophil chemotactic activity (ECA) has been found in serum after challenge of allergic asthmatic patients. In this study, we investigated changes in ECA in 40 birch-allergic patients during the birch pollen season; 20 of them had been treated with immunotherapy of birch pollen extract before the season. ECA raised significantly (p less than 0.001) in the untreated birch pollen-allergic patients during the season. Immunotherapy completely abolished this activity.
D000293:Adolescent; D000328:Adult; D002630:Chemotactic Factors / Q000097:blood*; D002631:Chemotactic Factors, Eosinophil / Q000097:blood*; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood* / Q000628:therapy; D012621:Seasons; D014197:Trees
D002630:Chemotactic Factors; D002631:Chemotactic Factors, Eosinophil