Experimental colorectal cancer as a model of human disease.
Colorectal cancer may now be induced consistently in experimental animals by the carcinogen 1,2-dimethylhydrazine (DMH). Adenomas and adenocarcinomas are produced in the large bowel and these resemble human colorectal cancer both macroscopically, and in their clinical behaviour. They are a close model of human disease and may be used for the evaluation of anti-cancer therapies and for the development of a diagnostic test for colorectal cancer.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D000236:Adenoma / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D004127:Dimethylhydrazines; D004195:Disease Models, Animal; D006801:Humans; D051381:Rats; D011919:Rats, Inbred Strains; D012004:Rectal Neoplasms / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy
D004127:Dimethylhydrazines