[Effect of chemical sympathectomy on the age dynamics of the heart rate and sensitivity of the heart to adrenaline and acetylcholine].
The guanethidine sympathectomy in 4- and 8-week old white rats increased cardiac sensitivity to acetylcholine. An increase of sensitivity to adrenaline was observed in 8 to 20 weeks of postnatal period. The significance of the changes of extracardiac effects and the cardiac sensitivity to acetylcholine and adrenaline for its chronotropic control in sympathectomized 10-14 week old rats is discussed.
D000109:Acetylcholine / Q000494:pharmacology*; D000375:Aging / Q000502:physiology*; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology*; D006145:Guanethidine; D006321:Heart / Q000294:innervation*; D006339:Heart Rate; D051381:Rats; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000502:physiology*
D000109:Acetylcholine; D004837:Epinephrine; D006145:Guanethidine
Vliianie khimicheskoĭ desimpatizatsii na vozrastnuiu dinamiku serdechnogo ritma i chuvstvitel'nost' serdtsa k adrenalinu i atsetilkholinu.