Effects of flunixin meglumine and dexamethasone on aqueous protein values after intraocular surgery in the dog.
Effects of flunixin meglumine and/or dexamethasone on aqueous protein concentrations were evaluated in dogs during and after intraocular surgery. Flunixin meglumine plus dexamethasone had the greatest inhibitory effect on postoperative aqueous protein increases with 64.2% inhibition over base-line aqueous protein values 24 hours after surgery. Dexamethasone alone had a 45.6% inhibition and flunixin meglumine alone had a 22.4% inhibition. Treatment with these drugs separately or in combination had a marked effect in decreasing postoperative inflammation.
D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000378:metabolism; D003002:Clonixin / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D003907:Dexamethasone / Q000494:pharmacology* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy; D004285:Dogs / Q000378:metabolism / Q000601:surgery*; D004359:Drug Therapy, Combination; D005136:Eye Proteins / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy / Q000662:veterinary; D009539:Nicotinic Acids / Q000494:pharmacology*; D013508:Ophthalmologic Surgical Procedures; D011183:Postoperative Complications / Q000188:drug therapy / Q000662:veterinary; D011897:Random Allocation
D005136:Eye Proteins; D009539:Nicotinic Acids; D003907:Dexamethasone; C014558:flunixin meglumine; D003002:Clonixin