The effect of 2,4-dihydroxypyridine-N-oxide, a new orally active iron chelator, on iron excretion in mice.
A comparative study of the iron chelating properties of 2,4-dihydroxypyridine-N-oxide with heteroaromatic chelators containing an alpha-ketohydroxy binding site has been performed in iron loaded mice labelled with 59Fe lactoferrin. All the chelators were administered at a dose of 300 mg/kg either intraperitoneally or intragastrically. The pyridine derivatives were the only chelators which caused increased 59Fe excretion following their intragastric administration to mice. 1,2-Dimethyl-3-hydroxypyrid-4-one was the most effective oral chelator of all, followed by 2,4-dihydroxypyridine-N-oxide which caused further increase in 59Fe excretion when it was administered twice a day at a 200 mg/kg dose.
D000818:Animals; D002614:Chelating Agents / Q000494:pharmacology*; D005243:Feces / Q000032:analysis; D007501:Iron / Q000378:metabolism* / Q000652:urine; D008297:Male; D051379:Mice; D011725:Pyridines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D002614:Chelating Agents; D011725:Pyridines; C051679:2,4-dihydroxypyridine N-oxide; D007501:Iron