Bioavailability of controlled-release metoclopramide. 1st communication: single dose study.
The bioavailability of metoclopramide monochloride hydrate after single dose oral administration of a controlled-release capsule (Gastro-Timelets) was compared with that of oral metoclopramide monochloride hydrate solution in four normal volunteers. 30 mg of each product was administered to each subject in a cross-over manner on two separate occasions and plasma metoclopramide levels were measured using a HPLC method. Although peak plasma metoclopramide concentrations were lower, and occurred later after capsule treatment than after solution, analysis of the area under the plasma concentration-time curve (AUC) values for the two formulations demonstrated that the products were equivalent in terms of the extent of absorption, with the mean AUC value (0-30 h) for the capsule 943.7 ng/h/ml and that for the solution 896.2 ng/h/ml.
D000328:Adult; D001682:Biological Availability; D003692:Delayed-Action Preparations; D004304:Dosage Forms; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000097:blood*
D003692:Delayed-Action Preparations; D004304:Dosage Forms; D008787:Metoclopramide