Changes in size and magnetic resonance signal intensity of the cerebral CSF spaces during the cardiac cycle as studied by gated, high-resolution magnetic resonance imaging.
In 1966, du Boulay demonstrated the pulsatile nature of CSF flow in the cerebral aqueduct by using air cineventriculography, which disturbs normal CSF dynamics by replacing part of the incompressible CSF with air. To investigate this phenomenon noninvasively, 35 normal volunteers were studied using high-resolution, cardiac-gated MR imaging. Specifically, we wished to document changes in size and configuration of the CSF spaces and the incidence and magnitude of signal loss (an indication of CSF motion) in these spaces as they related to time in the cardiac cycle. Changes in size and configuration were measurable in the third ventricle only (size increased during systole in seven of the 35 volunteers). Except for the lateral ventricles, some loss in signal intensity was seen in all CSF spaces at least during systole in all 35 volunteers--findings consistent with those of du Boulay. However, contrary to du Boulay's observations, asymmetric loss of signal, consistent with pulsatile CSF flow, was demonstrated at the level of the foramen of Monro in 15 of the 35 volunteers. Based on the pattern of flow void at the level of the foramen of Monro and on the expansion of the third ventricle during systole, we propose a theory of synchronous CSF flow at the foramen of Monro and aqueduct, which unifies our MR findings with du Boulay's cineventriculographic observations.
D000328:Adult; D001921:Brain / Q000033:anatomy & histology*; D002535:Cerebral Aqueduct / Q000033:anatomy & histology; D002552:Cerebral Ventricles / Q000033:anatomy & histology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D009200:Myocardial Contraction