WEB 2086. A potent PAF antagonist exerts protective effect toward PAF-induced gastric damage.
Single intravenous administration of platelet activating factor (PAF; 4 micrograms/kg) induced reproducible gastric damage in the conscious rat which was prevented by WEB 2086, a potent and specific PAF-antagonist. Intravenous and oral ED50s in protecting rats from gastric damage were 61 and 633 micrograms/kg, respectively. Because of the reported association between septic shock and gastrointestinal ulceration, the therapeutic potential of PAF-antagonists might be broader than previously thought.
D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced*; D014227:Triazines / Q000494:pharmacology*; D014230:Triazoles
D001381:Azepines; D010972:Platelet Activating Factor; D014227:Triazines; D014230:Triazoles; C052518:WEB 2086