Neuroleptic malignant syndrome during perphenazine treatment.
A 50-year old woman developed symptoms of a neuroleptic malignant syndrome with myoglobinuric renal failure during treatment with perphenazine. After discontinuation of perphenazine and repetitive haemodialysis, the patient recovered. Clinical characteristics of the syndrome, differential diagnosis and various therapeutic possibilities are shortly reviewed.
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000628:therapy; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D009212:Myoglobinuria / Q000139:chemically induced; D009459:Neuroleptic Malignant Syndrome / Q000503:physiopathology* / Q000628:therapy; D010546:Perphenazine / Q000009:adverse effects* / Q000627:therapeutic use; D011618:Psychotic Disorders / Q000188:drug therapy; D006435:Renal Dialysis
D003402:Creatine Kinase; D010546:Perphenazine