title: [Experimental fetal hydrocephalus. Ventriculo-amniotic shunt].
abstract: When the original idea was conceived 8 years ago to develop a surgical technique for the treatment of fetal hydrocephalus, the pathway towards prenatal surgery for this affection was totally unexplored. The operation appeared to be feasible because of the possibility of a ventriculo-amniotic shunt. The most important steps in our experimental studies in the ewe were creation of a fetal hydrocephalus by injection of a suspension of kaolin powder into cisterna magna; the treatment of the hydrocephalus by a mini-ventriculo-amniotic shunt, by cutting the cardiac end of a low pressure Pudenz pediatric catheter. Lambs were delivered by Cesarean two weeks before end of gestation. Coronal sections of brains of control and treated lambs showed reduction in hydrocephalus in the latter. These findings were the basis for the application of the method to treatment of human fetal hydrocephalus.
mesh_terms: D000650:Amnion; D000818:Animals; D002557:Cerebrospinal Fluid Shunts; D005333:Fetus / Q000601:surgery*; D006849:Hydrocephalus / Q000601:surgery*; D012756:Sheep
vernacular_title: Hydrocéphalie foetale expérimentale. Shunt ventriculo-amniotique.