Mechanism of oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+).
Oxidase electrode measurements have shown that the neurotoxin metabolite 1-methyl-4-phenyl-2,3-dihydropyridinium autoxidizes to hydrogen peroxide and 1-methyl-4-phenylpyridinium in a reaction promoted by iron chelates. The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity is discussed in the light of these findings.
D003676:Deferoxamine; D006861:Hydrogen Peroxide; D007700:Kinetics; D010084:Oxidation-Reduction; D011726:Pyridinium Compounds; D013056:Spectrophotometry, Ultraviolet
D011726:Pyridinium Compounds; C044755:1-methyl-4-phenyl-2,3-dihydropyridinium; D006861:Hydrogen Peroxide; D003676:Deferoxamine