title: [Significance of hepatitis B virus markers in children with acute and chronic hepatitis B in the familial spread of the infection].
abstract: Clinical, laboratory, and epidemiological examinations were carried out in 331 family members of 93 children with acute hepatitis B and 85 with chronic hepatitis B. Sensitive methods (passive hemagglutination test, radioimmunoassay, enzyme-immunoassay) were used for the detection of markers of hepatitis B virus: HBsAg, anti-HBs, HBeAg, and anti-HBe. Patients with chronic hepatitis B with prolonged HBs- and HBe-antigenemia were shown to play the main role in formation of the familial foci of HB virus infection, whereas the children with acute hepatitis B who, as a rule, had a short-time HBe-antigenemia, were of no great epidemiological importance for their family members. In the families of children suffering from chronic hepatitis B, infection with hepatitis B virus occurred most frequently in their mothers.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003289:Convalescence; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000235:genetics / Q000276:immunology* / Q000635:transmission; D006510:Hepatitis B Antibodies / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006513:Hepatitis B e Antigens / Q000032:analysis*; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens
vernacular_title: Znachenie markerov virusa gepatita B u deteĭ, bol'nykh ostrym i khronicheskim gepatitom B, v semeĭnom rasprostranenii infektsii.