Abnormal glial and glycoconjugate dispositions in the somatosensory cortical barrel field of the early postnatal reeler mutant mouse.
During early postnatal development in reeler mutant mice, lectin binding delineates prospective abnormal barrels as they will appear in the adult mutant somatosensory cortex. Glial fibers also may be more condensed within fascicles in developing reeler barrels. These fibers also appear to be misaligned, coursing predominantly in the tangential plane within the abnormal reeler barrel sides as opposed to having a radial orientation as seen in normal mouse barrels. The thalamic barreloid complex, however, reveals a disposition of glycoconjugates that is completely normal in reeler. Thus, there are anomalies in glia and associated glycoconjugates during mainly cortical development in the reeler mutant mouse that might be related to the primary action of the abnormal gene.
D000818:Animals; D050260:Carbohydrate Metabolism; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006824:Hybridization, Genetic; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008818:Mice, Neurologic Mutants / Q000254:growth & development* / Q000378:metabolism; D009457:Neuroglia / Q000166:cytology* / Q000378:metabolism; D013003:Somatosensory Cortex / Q000254:growth & development* / Q000378:metabolism
D005904:Glial Fibrillary Acidic Protein