Modification by alpha-tocopherol, propyl gallate and tertiary butylhydroquinone of urinary bladder carcinogenesis in Fischer 344 rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
The promoting activity of 3 antioxidants, alpha-tocopherol (alpha-TP), propyl gallate (PG) and tertiary butylhydroquinone (TBHQ) in urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in male F344 rats was examined. Rats, 6-week-old, were treated with 0.05% BBN in the drinking water for 4 weeks and then administered 1.50, 0.75 or 0.38% alpha-TP, 1.0% PG or 2.0% TBHQ in the diet for 32 weeks. The urinary bladder of all animals was examined histologically after the total 36 experimental weeks. The incidence of papillary or nodular hyperplasia (PN hyperplasia) of the urinary bladder was significantly higher in the rats treated with BBN followed by 2.0% dietary TBHQ that in controls initiated with 0.05% BBN followed by control diet. This result indicates that TBHQ has weak promoting activity in urinary bladder carcinogenesis. alpha-TP and PG did not demonstrate a promoting effect for urinary bladder lesions.
D000818:Animals; D002085:Butylhydroxybutylnitrosamine; D003043:Cocarcinogenesis; D005707:Gallic Acid / Q000031:analogs & derivatives*; D006873:Hydroquinones / Q000494:pharmacology*; D008297:Male; D009602:Nitrosamines; D011435:Propyl Gallate / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*; D014810:Vitamin E / Q000494:pharmacology*
D006873:Hydroquinones; D009602:Nitrosamines; D014810:Vitamin E; D002085:Butylhydroxybutylnitrosamine; D005707:Gallic Acid; D011435:Propyl Gallate; C018855:2-tert-butylhydroquinone