Animal model: genetic control of the survival of trisomic fetuses in mice: a preliminary report.
Using trisomy 19 produced experimentally in mice, we examined the genetic control of the survival of trisomic fetuses. Data are presented that show clearly that the prevalence of experimentally produced trisomy 19 in mice, observed on day 15 of gestation, is genetically influenced. There appeared to be an inverse relationship between strain differences in frequency of trisomy 19 fetuses and frequency of fetal loss, suggesting that the observed differences in prevalence of trisomy 19 fetuses resulted from differential survival of trisomic fetuses.
D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D005313:Fetal Death; D005865:Gestational Age; D051379:Mice; D008815:Mice, Inbred Strains / Q000196:embryology / Q000235:genetics*; D011247:Pregnancy; D014314:Trisomy