title: Immunosuppressive properties of new side chain sterol hydroperoxides and of the corresponding alcohols.
abstract: New side chain sterol hydroperoxides derived from stigmastane and their corresponding alcohols could suppress the murine or human cell lymphoproliferation induced by T and B cell mitogens. The suppressive effect is dose and time dependent. Comparison of the activities of the different compounds suggests that the position of the hydrophilic group at C-29 is of greater importance than the hydroxyl or hydroperoxide function itself. Hence a new compound stigmasta-5,24 (28) diene-3,29 diol, appears to be highly effective.
mesh_terms: D000818:Animals; D006801:Humans; D007166:Immunosuppressive Agents; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008809:Mice, Inbred C3H; D008934:Mitogens / Q000494:pharmacology; D010840:Phytosterols / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D007166:Immunosuppressive Agents; D008934:Mitogens; D010840:Phytosterols