[Modelling of the parkinsonian syndrome by the administration of kainic acid into the caudate nucleus].
The experiments on rats have shown that bilateral administration of kainic acid (0.1-0.15 microgram) into the rostral parts of caudate nuclei led to the development of hypokinesia and rigidity. An increase in the electrical activity--the formation of the generator of pathologically increased excitement (GPIE) was noted in a zone of kainic acid injection. Rigidity and hypokinesia were attenuated and the GPIE activity was depressed after cyclodol (1-10 mg/kg) or L-DOPA (100-200 mg/kg) administration. Combined administration of cyclodol (2 mg/kg) and L-DOPA (50 mg/kg) induced potentiated antiparkinsonian effect. Dopamine microinjections into the GPIE area depressed its activity and abolished rigidity and hypokinesia. These data suggest that the Parkinson syndrome develops under the influence of GPIE induced by kainic acid administration into caudate nuclei.
D000818:Animals; D002421:Caudate Nucleus; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004567:Electrodes, Implanted; D004569:Electroencephalography; D005260:Female; D007267:Injections; D007608:Kainic Acid / Q000494:pharmacology*; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000188:drug therapy; D051381:Rats; D013997:Time Factors; D014282:Trihexyphenidyl / Q000627:therapeutic use
D007980:Levodopa; D014282:Trihexyphenidyl; D007608:Kainic Acid
Modelirovanie parkinsonicheskogo sindroma putem vvedeniia kainovoĭ kisloty v khvostatye iadra mozga.