title: Morphine selectively suppresses the slow response of tooth pulp-driven neurons in first somatosensory cortex (SI) of the cat.
abstract: Tooth pulp-driven (TPD) neurons are found in the oral area of the first somatosensory cortex (SI) and they have been classified into fast (F-) type, slow (S-) type and fast type accompanied by afterdischarges (Fa). Effects of morphine on single unit responses of the F- and S-type neurons to pulp stimulation were examined by recording the discharges from a single neuron using a microelectrode. Intraperitoneal administration of morphine at 1.5 mg/kg markedly suppressed the response of S-type TPD neurons that fire with a long latency. This effect was completely reversed by naloxone at 0.2 mg/kg. On the other hand, the discharges of F-type neurons that fire with a short latency were not affected by application of morphine at 3 mg/kg. These findings suggest that S-type neurons in SI are concerned with pain perception.
mesh_terms: D000818:Animals; D002415:Cats; D003782:Dental Pulp / Q000187:drug effects / Q000294:innervation*; D004558:Electric Stimulation; D004594:Electrophysiology; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000503:physiopathology; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000502:physiology
chemical_list: D009270:Naloxone; D009020:Morphine