[Development of lung tumors in BALB/c mice in chronic influenza infection and inhalation of metal-containing aerosols].
Intensification of cocarcinogenic effect of chronic influenza infection (10 months after virus instillation) in BALB/c mice was obtained by polymetallic aerosol inhalation 5 or 6 months after infection. An increase of malignant neoplasms incidence was accompanied by a decrease of the cytoproliferative activity in the thymus and spleen. The immunopathogenic and cocarcinogenic effects were maximal when the aerosol treatment was carried out 6 months after infection.
D000336:Aerosols; D000818:Animals; D002908:Chronic Disease; D003043:Cocarcinogenesis; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D008670:Metals / Q000633:toxicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000150:complications*
D000336:Aerosols; D008670:Metals
Vozniknovenie opukholeĭ legkikh u mysheĭ BALB/c pri khronicheskoĭ grippoznoĭ infektsii i ingaliatsii metallosoderzhashchego aérozolia.