title: [Pharmacological effect of exogenous histones on muscles].
abstract: Different histone fractions contain sequences homologous to those of several regulatory peptides. All the histone fractions demonstrated dose-dependent positive chronotropic effect in spontaneously contracting rat atrial preparations. The range of their activity was as follows: H4 greater than H1 greater than H2a much greater than H3. Synthetic COOH-terminal histone H4 pentapeptide (historphin) Tyr-Gly-Phe-Gly-Gly demonstrated opioid activity by inhibiting electrostimulated guinea-pig ileal contractions. It is suggested that some biological activities of histones are related to the presence of regulatory peptide sequences in their structure.
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D006657:Histones / Q000302:isolation & purification / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006657:Histones
vernacular_title: Farmakologicheskoe vliianie ékzogennykh gistonov na myshtsy.