[Specific anosmia to isovaleric acid in the peripheral portion of the olfactory analyzer of the laboratory mouse].
The olfactory mucosa of laboratory male mice of lines C57BL/6 and AKR was stimulated by vapours of isovaleric acid and isoamylacetate of various concentrations. Study of electro-olfactography has demonstrated that mice of line C57BL/6 were insensitive to isovaleric acid of concentrations from 10(-5) to 10(-3) mol/l and remained normally sensitive to isoamylacetate. The mice of line AKR were sensitive to isovaleric acid of the same concentrations. The authors suggest using mice of these line as a model for investigations of the olfactory reception mechanisms.
D000818:Animals; D004594:Electrophysiology; D045782:Hemiterpenes; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D009430:Neural Analyzers / Q000503:physiopathology*; D000857:Olfaction Disorders / Q000235:genetics* / Q000503:physiopathology; D009831:Olfactory Mucosa / Q000503:physiopathology*; D010421:Pentanoic Acids; D000439:Pentanols; D012903:Smell / Q000502:physiology*
D045782:Hemiterpenes; D010421:Pentanoic Acids; D000439:Pentanols; C008216:isovaleric acid; C020377:isoamyl acetate
Spetsificheskaia anosmiia k izovalerianovoĭ kislote v perifericheskom otdele oboniatel'nogo analizatora laboratornoĭ myshi.