Duodenal G- and D-cell changes following corticosteroid administration. Immunocytochemical long-term study in guinea pigs.
Prednisolone administration in guinea pigs for 20 days induces significant hypergastrinemia and duodenal G-cell hyperplasia. Hypergastrinemia and duodenal G-cell hyperplasia are less prominent following 40 days of prednisolone administration and this could be partly attributed to the duodenal D-cell increased activity, which represents an adaptive response to the alterations of gastric secretory functions induced by corticosteroids.
D000818:Animals; D004386:Duodenum / Q000187:drug effects*; D005755:Gastrins / Q000097:blood*; D006168:Guinea Pigs; D006965:Hyperplasia; D007413:Intestinal Mucosa / Q000187:drug effects*; D008297:Male; D011239:Prednisolone / Q000633:toxicity*; D013997:Time Factors
D005755:Gastrins; D011239:Prednisolone