Cholinergic manipulations in the rat basolateral amygdaloid nucleus on locomotor activity induced by amphetamine.
Microinjections of cholinergic antagonists in the vicinity of the basolateral amygdaloid nucleus produced a marked reduction of amphetamine-induced hyperactivity when amphetamine was administered i.p. in relatively large doses (1.5 mg/kg). Cholinergic agonists enhanced locomotor activity induced by relatively small doses of amphetamine (0.5 mg/kg). These observations suggest that cholinergic activity in the amygdala modulates the locomotor response to amphetamine.
D000661:Amphetamine / Q000494:pharmacology*; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010095:Oxotremorine / Q000494:pharmacology; D010275:Parasympathetic Nervous System / Q000502:physiology*; D010830:Physostigmine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012601:Scopolamine / Q000494:pharmacology
D010095:Oxotremorine; D001285:Atropine; D010830:Physostigmine; D000661:Amphetamine; D012601:Scopolamine