Changes in ovarian function associated with oxytocin injection to immature rats.
The effects of oxytocin on ovarian function have been studied in immature rats of 25 days of age. The hormone was injected subcutaneously daily for 5 days in two doses: 50 and 250 millimicrons per animal, to intact females, hysterectomized or injected simultaneously with indomethacin (2 mg/kg). Ovarian and uterine weights increased in all treated animals. Plasma estradiol 17 beta levels increased, while plasma progesterone level did not change. The relevance of this study was to precise the trophic role of oxytocin on ovary and uterus. The changes observed did not seem to be associated with prostaglandin E secretion.
D000818:Animals; D004958:Estradiol / Q000097:blood; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007279:Injections, Subcutaneous; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects* / Q000502:physiology; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000187:drug effects
D004958:Estradiol; D010121:Oxytocin; D007213:Indomethacin