Complications of subconjunctival 5-fluorouracil following glaucoma filtering surgery.
The antimetabolite 5-fluorouracil (5-FU) has been used to inhibit fibroblastic growth to increase the success rate in glaucoma filtration surgery. Subconjunctival 5-FU can have adverse side effects. This paper describes two cases in detail of the ocular side effects of 5-FU. The first case is representative of the ocular surface problems. The second case deals with bleb leaks. Relative contraindications to 5-FU treatment are pre-existing ocular surface problems, early postoperative bleb leaks and fornix-based conjunctival flaps in filtering procedures. New drug delivery methods are presently being investigated to help decrease the adverse side effects and increase the efficacy of 5-FU.
D000368:Aged; D000369:Aged, 80 and over; D003228:Conjunctiva; D003229:Conjunctival Diseases / Q000139:chemically induced*; D003316:Corneal Diseases / Q000139:chemically induced*; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care
D005472:Fluorouracil