Anaphylaxis after intra-articular injection of orgotein. Detection of an IgE-mediated mechanism.
Orgotein, a recently introduced anti-inflammatory agent, is the generic name accepted in the U.S.A. for the drug version of copper-zinc superoxide dismutase. This metallo-enzyme is obtained from bovine liver and has a molecular weight of about 32,000. We report on a patient to whom an intra-articular injection of orgotein caused an anaphylactic reaction. An IgE-mediated mechanism was suggested by an immediate positive skin test to orgotein and by the finding of specific IgE against orgotein in the patient's serum.
D000328:Adult; D000707:Anaphylaxis / Q000209:etiology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000918:Antibody Specificity; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007270:Injections, Intra-Articular; D008297:Male; D008667:Metalloproteins / Q000008:administration & dosage / Q000009:adverse effects*; D012882:Skin Tests; D013482:Superoxide Dismutase / Q000009:adverse effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008667:Metalloproteins; D007073:Immunoglobulin E; D013482:Superoxide Dismutase; C005180:orgotein