The concentration and chemical status of arsenic in the early placentas of arsenate-dosed hamsters.
We determined the concentration and chemical status of arsenic in the placentas of hamsters following continuous exposure via the osmotic minipump to minimally and frankly teratogenic doses of arsenate. Close to 70% of the placental arsenic is bound to macromolecules, two-thirds of which is dialyzable. The remaining 30% of arsenic consists of low molecular weight species, predominantly inorganic arsenic. This mix is the same for minimally teratogenic and frankly teratogenic doses of arsenate.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D001149:Arsenates / Q000378:metabolism / Q000633:toxicity; D001151:Arsenic / Q000378:metabolism*; D006224:Cricetinae; D005260:Female; D008970:Molecular Weight; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
D001149:Arsenates; D001151:Arsenic; C025657:arsenic acid