Renal functional relationships in dogs with glomerulopathies.
Glomerular filtration rate, effective renal plasma flow, and filtration fraction were determined by measuring plasma disappearance of [14C] inulin and [3H]tetraethylammonium bromide after a single IV bolus injection was given to 8 dogs with membranous nephropathy, renal glomerulosclerosis, or renal amyloidosis. Glomerular filtration rate was decreased in the 8 dogs. Effective renal plasma flow was within reference values in 1 dog, increased in 1 dog, and decreased in 6 dogs. Filtration fraction was within reference values in 2 dogs and decreased in 6 dogs. The glomerular filtration rate also was estimated by the endogenous creatinine clearance technique and was decreased in the 8 dogs with glomerulopathies.
D000818:Animals; D001783:Blood Flow Velocity; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate; D007444:Inulin; D007674:Kidney Diseases / Q000503:physiopathology / Q000662:veterinary*; D007678:Kidney Glomerulus / Q000503:physiopathology*; D008297:Male; D012079:Renal Circulation; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds
D013757:Tetraethylammonium Compounds; D019789:Tetraethylammonium; D007444:Inulin