Efficacies of trimethoprim-sulfadiazine and gentamicin sulfate in the treatment of fibrinous peritonitis in rats.
Trimethoprim-sulfadiazine and gentamicin sulfate decreased early mortality in an established model of fibrinous peritonitis in the rat. Both drugs failed to prevent abscess formation, indicating that there was poor penetration of fibrin; however, they significantly decreased (P less than 0.01) bacterial numbers in residual abscesses. The colony count per abscess in the gentamicin sulfate-treated group was significantly lower (P less than 0.01) than that in the trimethoprim-sulfadiazine-treated group.
D000818:Animals; D004195:Disease Models, Animal; D004338:Drug Combinations / Q000627:therapeutic use; D005839:Gentamicins / Q000627:therapeutic use*; D008297:Male; D010538:Peritonitis / Q000188:drug therapy / Q000662:veterinary*; D051381:Rats; D011919:Rats, Inbred Strains; D013411:Sulfadiazine / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D000096926:Benzenesulfonamides
D004338:Drug Combinations; D005839:Gentamicins; D013411:Sulfadiazine; D014295:Trimethoprim; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides