title: [Clinical experience using streptodecase in the prehospital stage of treatment of acute myocardial infarct].
abstract: The effects of prehospital streptodecase administration on clinical course, pattern of necrosis formation, myocardial contractility and blood coagulation were studied in 15 patients with acute myocardial infarction. Patients to whom thrombolytic and anticoagulant therapy was contraindicated made up the control group. A single intravenous jet injection of the total streptodecase dose (3,000,000 U) is well tolerated by patients with acute myocardial infarction without preliminary testing. Prehospital use of the drug contributes to rapid stabilization and limitation of progressive myocardial necrosis, and improves thereby the clinical course of the disease.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005392:First Aid; D006801:Humans; D007275:Injections, Intravenous; D007277:Injections, Jet; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000188:drug therapy*; D009206:Myocardium / Q000473:pathology; D013300:Streptokinase / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase
vernacular_title: Klinicheskiĭ opyt primeneniia streptodekazy na dogospital'nom étape lecheniia ostrogo infarkta miokarda.