Increased lactate dehydrogenase in serum in measles infection.
We determined lactate dehydrogenase (LD; EC 1.1.1.27) in serum from 75 sequential measles patients and 105 control patients. In the measles patients, LD was increased to 1147.9 +/- 43.8 (mean +/- SE) U/L, markedly more than in the control group (517.2 +/- 15.0 U/L, p less than 0.001). Both LD-3 and LD-4 isoenzymes were increased, but the concentration of LD-5 was normal. Patients with high LD values (greater than 1500 U/L) had longer hospital stays than did those with lower values (p less than 0.01). Our results suggest that increased LD in serum is a common finding in measles infection and presumably originates from lymphocytes.
D001991:Bronchitis / Q000150:complications; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007527:Isoenzymes; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D007827:Laryngitis / Q000150:complications; D008457:Measles / Q000150:complications / Q000201:enzymology*; D011014:Pneumonia / Q000150:complications
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase