title: Glycogenolysis and lactogenesis in the ischemic diabetic rat heart.
abstract: The effect of 30 min of myocardial ischemia on cardiac glycogenolysis and lactate accumulation was investigated in streptozotocin (STZ) diabetic and normal rats. In normal rats, ischemia caused a significant reduction in cardiac glycogen and a significant increase in cardiac lactate. STZ rats experienced a similar, but larger, reduction in cardiac glycogen with ischemia but did not accumulate significant quantities of lactic acid suggesting that diabetic rats have a reduced capacity for non-oxidative carbohydrate metabolism in myocardial ischemia.
mesh_terms: D000818:Animals; D003327:Coronary Disease / Q000150:complications / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000378:metabolism; D005215:Fasting; D006003:Glycogen / Q000378:metabolism*; D007773:Lactates / Q000096:biosynthesis*; D019344:Lactic Acid; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming
chemical_list: D007773:Lactates; D019344:Lactic Acid; D006003:Glycogen