title: Determination of the thermodynamic ionization constants of cefroxadine.
abstract: The values of the thermodynamic ionization constants of the carboxylic (pK = 3.30 +/- 0.02) and amine (pK = 7.00 +/- 0.06) groups of cefroxadine were determined at 35.0 degrees C using potentiometric data. The apparent ionization constants of these groups were also determined at 35.0 degrees C, and at different values of ionic strength.
mesh_terms: D002511:Cephalosporins; D002515:Cephradine / Q000031:analogs & derivatives; D007477:Ions; D008433:Mathematics; D011199:Potentiometry; D013816:Thermodynamics
chemical_list: D002511:Cephalosporins; D007477:Ions; C012671:cefroxadine; D002515:Cephradine