[Immunomodulating action of neuropeptides in in vitro systems].
The work presents the data on the immunostimulating properties of neuropeptides. As revealed in this study, the leu-enkephalin level in blood sera (taken from 55 patients) inversely correlates with the intensity of the proliferative response of lymphocytes to phytohemagglutinin. In in vitro systems dalargin promotes the increase or decrease of the proliferative response of lymphocytes to phytohemagglutinin, depending on the proliferative activity of cells in response to this mitogen, and also leads to an increase in the number of rosette-forming cells. Leu-enkephalin in doses of 100, 10, 1, 0.1 micrograms/ml and dalargin in a dose of 0.1 microgram/ml inhibit the migration of leukocytes.
D000276:Adjuvants, Immunologic; D002464:Cell Migration Inhibition; D002478:Cells, Cultured; D003327:Coronary Disease / Q000097:blood; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D009479:Neuropeptides / Q000494:pharmacology*; D012397:Rosette Formation
D000276:Adjuvants, Immunologic; D009479:Neuropeptides; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Immunomoduliruiushchee deĭstvie neĭropeptidov v sistemakh in vitro.