Inhibition of rat brain monoamine oxidase and succinic dehydrogenase by anticonvulsant pyrazolines.
Substituted 1,5-diaryl-3(4-chlorophenyl)-delta 2-pyrazolines were synthesized and evaluated for anticonvulsant activity. Most pyrazolines (100 mg/kg) provided 20-80% protection against pentylenetetrazol-induced convulsions in mice. All compounds inhibited rat brain mitochondrial monoamine oxidase (MAO) and succinic dehydrogenase (SDH) and exhibited low toxicity as reflected by approximate LD50 values (500 to greater than 1000 mg/kg) in mice.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology*; D066298:In Vitro Techniques; D008928:Mitochondria / Q000201:enzymology; D008996:Monoamine Oxidase Inhibitors; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors*
D000927:Anticonvulsants; D008996:Monoamine Oxidase Inhibitors; D011720:Pyrazoles; D013385:Succinate Dehydrogenase