title: [Multifactorial pathogenesis and immunoendocrine modulation of multiple sclerosis].
abstract: The results of immunogenetic screening of 300 patients with multiple sclerosis (MS) were subjected to factorial analysis. Nine significant factors indicative of secondary immunodeficiency were elucidated. The development and course of the disease were found to be affected by lipid metabolism disorders and endocrine deviations in the thymus-adrenal system. The authors postulate the principle of permanent immunoendocrine modulation in the treatment of MS. They also present data on hemosorption, lympho- and immunostimulation, as well as on correction of the interferon and cytochrome system.
mesh_terms: D000309:Adrenal Insufficiency / Q000150:complications; D001323:Autoantibodies; D001812:Blood-Brain Barrier; D001921:Brain / Q000276:immunology; D006801:Humans; D007958:Leukocyte Count; D008074:Lipoproteins / Q000097:blood; D008214:Lymphocytes / Q000276:immunology; D009103:Multiple Sclerosis / Q000097:blood / Q000209:etiology* / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology / Q000503:physiopathology
chemical_list: D001323:Autoantibodies; D008074:Lipoproteins
vernacular_title: Mul'tifaktorial'nost' patogeneza i immunoéndokrinnaia moduliatsiia rasseiannogo skleroza.