Streptokinase salvage of a free-tissue transfer: case report and review of the literature.
Postoperative thrombosis is a devastating complication after a microvascular free-tissue transfer. We are reporting the case of a clinical free osteomyocutaneous flap (fibula, peroneal, and soleus muscle, and skin) which suffered recalcitrant postoperative venous thrombosis and was salvaged only after isolated selective infusion of streptokinase. The use of a fibrinolytic agent or plasminogen activator for this purpose in humans has not previously been reported.
D000328:Adult; D001134:Arm Injuries / Q000601:surgery; D005542:Forearm / Q000098:blood supply*; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy*; D013300:Streptokinase / Q000627:therapeutic use*; D013524:Surgical Flaps; D013927:Thrombosis / Q000188:drug therapy*; D014680:Veins
D013300:Streptokinase