Immunosuppressive properties of new side chain sterol hydroperoxides and of the corresponding alcohols.
New side chain sterol hydroperoxides derived from stigmastane and their corresponding alcohols could suppress the murine or human cell lymphoproliferation induced by T and B cell mitogens. The suppressive effect is dose and time dependent. Comparison of the activities of the different compounds suggests that the position of the hydrophilic group at C-29 is of greater importance than the hydroxyl or hydroperoxide function itself. Hence a new compound stigmasta-5,24 (28) diene-3,29 diol, appears to be highly effective.
D000818:Animals; D006801:Humans; D007166:Immunosuppressive Agents; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008809:Mice, Inbred C3H; D008934:Mitogens / Q000494:pharmacology; D010840:Phytosterols / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D007166:Immunosuppressive Agents; D008934:Mitogens; D010840:Phytosterols