title: Diethylstilbestrol-related clear-cell adenocarcinoma in women with initial examinations demonstrating no malignant disease.
abstract: The DES Screening Center of Queens, Nassau, and Suffolk counties has screened approximately 2000 diethylstilbestrol (DES)-exposed women since its inception in 1979. Four women, who at their initial visit were noted to have only nonmalignant DES-related changes, subsequently developed clear-cell adenocarcinoma while under observation, between 18-81 months after their first colposcopy. The age at diagnosis ranged from 16-31. Three patients had been receiving close follow-up; one had not. These cases emphasize the need for frequent follow-up for these patients using careful inspection and palpation, vaginal and cervical cytology, colposcopy, and colposcopically directed biopsy of suspicious areas.
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D000328:Adult; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D014621:Vagina / Q000601:surgery
chemical_list: D004054:Diethylstilbestrol