title: Carbohydrate metabolism of dog skeletal muscle during immobilization.
abstract: The effect of immobilization and the following mobilization on muscle carbohydrate metabolism was investigated in dogs. Total carbohydrate and glycogen content of skeletal muscle fell during immobilization. The glycogen-degrading enzyme phosphorylase was activated 1 week after immobilization (a/b ratio 40.6 +/- 7.6 vs. 27.1 +/- 6.5%). Thereafter, the enzyme activity decreased and remained significantly lowered even 2 weeks after the following mobilization. In contrast, muscle glucose and lactate concentration were unchanged. Our data indicates glycogen breakdown of dog skeletal muscle during immobilization. Even after 2 weeks of mobilization muscle glycogen content has not reached glycogen values of the untreated dogs.
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism; D004285:Dogs; D005260:Female; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007103:Immobilization; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D009132:Muscles / Q000378:metabolism*; D006005:Phosphorylases / Q000378:metabolism; D013997:Time Factors
chemical_list: D007773:Lactates; D019344:Lactic Acid; D006003:Glycogen; D006005:Phosphorylases; D005947:Glucose