Comparison of selected pharmacological properties of trofosfamide and its enantiomeric derivatives.
Comparison of pharmacological properties of commercial, racemic trofosfamide (Ixoten) and its dextrorotatory and levorotatory derivatives was performed in experiments on mice. Acute and cumulative toxicity, behavioral screening tests and effects of subchronic treatment (growth of body mass, mortality, blood morphology, proteins level, enzymes activity, microscopic evaluation of liver slices) were taken into account. Summarized data revealed more pronounced toxicity of enantiomers, particularly D-form, as compared with racemate.
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001831:Body Temperature / Q000187:drug effects; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D010528:Peristalsis / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D003520:Cyclophosphamide; C003726:trofosfamide