title: Adrenergic and angiotensin II influences on renal vascular tone in chronic sodium depletion.
abstract: To examine the role of adrenergic activity on the reduction in nephron filtration rate during chronic sodium depletion in rats, we have measured all the determinants of glomerular ultrafiltration before and after acute unilateral renal denervation. We also examined whether this adrenergic influence was angiotensin II mediated by performing the same protocol with the addition of systemic infusion of an angiotensin-converting enzyme inhibitor, MK 421. The results indicate that both angiotensin II and adrenergic activity contribute to the maintenance of renal vascular resistance during chronic sodium depletion. Acute renal denervation restored nephron filtration rate in chronic sodium-depleted rats (27 +/- 1 to 32 +/- 2 nl/min, P less than 0.05) to control levels (33 +/- 1 nl/min) via reductions in afferent and efferent arteriolar resistances, which also increased nephron plasma flow (85 +/- 5 to 109 +/- 6 nl/min, P less than 0.05). Infusion of MK 421 also increased plasma flow in chronic sodium-depleted rats (116 +/- 11 nl/min, P less than 0.05) through decreases in both arteriolar resistances. Denervation in MK 421-treated rats further increased nephron plasma flow to 137 +/- 10 nl/min (P less than 0.05) only as a result of decreased afferent resistance. The findings indicate that the glomerular hemodynamic changes that characterize chronic sodium depletion are primarily due to the activity of angiotensin II. However, renal adrenergic activity contributes an independent effect on afferent resistance and an effect on efferent resistance via adrenergic effects on angiotensin II.
mesh_terms: D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000502:physiology*; D000818:Animals; D002908:Chronic Disease; D003714:Denervation; D005919:Glomerular Filtration Rate; D006439:Hemodynamics; D007668:Kidney / Q000294:innervation*; D008297:Male; D009129:Muscle Tonus; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation; D012964:Sodium / Q000172:deficiency*; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D014666:Vasomotor System / Q000503:physiopathology*
chemical_list: D000804:Angiotensin II; D012964:Sodium