The oral retention and antiplaque efficacy of triclosan in human volunteers.
An antiplaque toothpaste containing 0.2% (w/w) triclosan significantly inhibited overnight plaque growth in 12 human volunteers. After use of a 1 g quantity of the toothpaste containing 0.2% (w/w) [3H]-triclosan, 36.3 +/- 1.4% of the triclosan was retained. The mean concentration (+/- s.d.) achieved in saliva 5 min after toothpaste use was 8.16 +/- 2.50 micrograms g-1. The saliva decay curve for triclosan was consistent with a two phase model with t1/2 values of 0.45 h and 2.42 h, respectively. Triclosan was present in bacterial plaque for at least 8 h after dosage and in the oral mucosa for at least 3 h.
D000328:Adult; D003773:Dental Plaque / Q000188:drug therapy*; D006207:Half-Life; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000378:metabolism; D010647:Phenyl Ethers / Q000627:therapeutic use*; D012463:Saliva / Q000378:metabolism; D014100:Toothpastes; D014260:Triclosan / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*
D010647:Phenyl Ethers; D014100:Toothpastes; D014260:Triclosan