title: [Solitary lesions of the rectum caused by suppositories combining acetylsalicylic acid and paracetamol].
abstract: The reports of 8 female patients who, because of recurrent headache, were using analgesic suppositories containing acetylsalicylic acid and paracetamol (Perdolan) for more than two years are analyzed. Symptoms were nonspecific: anal pain, rectal tenesmus or bleeding. The lesions were located within 8 cm from the anal verge and consisted of superficial ulcerations, fibrotic scar tissue and rectal stenosis. Biopsies showed non-specific inflammation, limited to the rectum. Rectal prolapse or intussusception was not associated. By discontinuing the use of suppositories, symptoms usually resolved; rectal stenoses required anorectal dilatations and in 2 cases surgical resection. When solitary rectal lesions are observed in the absence of rectal prolapse, chemical aggression of the rectal mucosa by use of suppositories containing acetylsalicylic acid should be considered.
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008875:Middle Aged; D012002:Rectal Diseases / Q000139:chemically induced*; D012007:Rectum / Q000187:drug effects* / Q000473:pathology; D013488:Suppositories; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D013488:Suppositories; D000082:Acetaminophen; D001241:Aspirin
vernacular_title: Lésions solitaires du rectum dues à des suppositoires associant acide acétylsalicylique et paracétamol.