[Mechanism of the anti-tumoral effect of the blastolysin fraction isolated from Lactobacillus bulgaricus].
A blastolysin fraction, isolated from lysosyme lysates of Lactobacillus Bulgaricus strain 51 by gel chromatography, was shown to markedly inhibit the growth of sarcoma S-180. A single administration of the agent was followed by an insignificant decrease in tumor growth rate, while repeated treatment induced a complete regression of tumor in 15% of animals and resulted in a prolonged suppression of tumor growth in the others. Cells isolated from metastases which developed after the withdrawal of the drug retained susceptibility to fraction 2 of blastolysin. The latter fraction showed a similar pattern of inhibition of the growth of Ehrlich ascites tumor but did not affect hemocytoblastosis in mice LA. Histologically, fraction 2 produced tumor cell necrosis which commenced at 24 hours posttreatment. Such signs of hypercorticoidism as lysis of lymphocytes in the cortical layer of the thymus, depletion of T-dependent zones of spleen and lymph nodes and adrenal cortical hyperplasia were registered. Macrophage level in tumor was not increased. A 7-fold rise in murine serum corticosterone level at 1 hour posttreatment was established by the method of competitive protein binding.
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use*; D000302:Adrenal Cortex / Q000503:physiopathology; D000818:Animals; D000900:Anti-Bacterial Agents; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D003345:Corticosterone / Q000097:blood; D006020:Glycopeptides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D007113:Immunity, Innate; D007778:Lactobacillus / Q000276:immunology; D051379:Mice; D009374:Neoplasms, Experimental / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D012510:Sarcoma 180 / Q000276:immunology / Q000503:physiopathology / Q000628:therapy
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D006020:Glycopeptides; C025182:blastolysin; D003345:Corticosterone
K mekhanizmu protivoopukholevogo deĭstviia fraktsii blastolizina, vydelennoĭ iz Lactobacillus bulgaricus.