A pilot study of combined trazodone and tryptophan in obsessive-compulsive disorder.
An open pilot trial of combined trazodone and tryptophan for 11 patients with Obsessive-Compulsive Disorder was conducted to test the hypothesis that increasing serotonin activity is therapeutic for this condition. Results were not encouraging; several patients tolerated the combination poorly, but even among patients completing 2 weeks' treatment benefit was marginal.
D000293:Adolescent; D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D014196:Trazodone / Q000009:adverse effects / Q000627:therapeutic use*; D014364:Tryptophan / Q000009:adverse effects / Q000627:therapeutic use*
D012701:Serotonin; D014364:Tryptophan; D014196:Trazodone