[Stimulation of the immune response during blockade of serotonin receptors by cyproheptadine].
The role of serotonin receptors in the inhibitory effect of serotoninergic system on immunogenesis was studied using cyproheptadine, a specific blocker of 5-HT2 receptors. It was shown that cyproheptadine administration to CBA mice stimulated the immune response, which was dopamine-dependent and was realized via thymus. With the pituitary stalk destruction, the stimulatory effect of cyproheptadine was not observed, which suggests the participation of 5-HT2 brain receptors in immunogenesis.
D000276:Adjuvants, Immunologic; D000818:Animals; D003533:Cyproheptadine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D007114:Immunization; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011985:Receptors, Serotonin / Q000187:drug effects*; D012397:Rosette Formation; D012701:Serotonin / Q000276:immunology*; D013934:Thymectomy
D000276:Adjuvants, Immunologic; D011985:Receptors, Serotonin; D003533:Cyproheptadine; D012701:Serotonin; D006220:Haloperidol
Stimuliatsiia immunnogo otveta pri blokade serotoninovykh retseptorov tsiprogeptadinom.