[Secretory immunoglobulin A (S-IgA) in the amniotic fluid supports the fetal maturity profile].
Amniotic fluid levels of secretory immunoglobulin A(S-IgA) were measured by single radial immunodiffusion according to the method of Mancini using a monospecific antiserum against the human secretory component. 114 amniotic fluid samples were examined. The S-IgA values showed a correlation (r = 0.49) with the phospholipid levels. Additionally, it was observed no correlation between Serum and amniotic fluid S-IgA concentrations estimated as parallel investigations in 20 patients. S-IgA values greater than or equal to 82 mg/l were used to diagnose a sufficient fetal lung maturity. False negative values of S-IgA are possible. In 19 cases of newborns without signs of respiratory distress syndrome amniotic fluid S-IgA estimations were performed up to 32 hours before the delivery. False negative phospholipid levels were estimated in 2 cases, false negative S-IgA levels in 4 cases. The measurement of S-IgA in amniotic fluid will serve as an additional parameter for the estimation of fetal lung maturity.
D000649:Amniocentesis; D000653:Amniotic Fluid / Q000276:immunology*; D005260:Female; D005325:Fetal Organ Maturity; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D008168:Lung / Q000196:embryology*; D010743:Phospholipids / Q000032:analysis; D011247:Pregnancy
D007071:Immunoglobulin A, Secretory; D010743:Phospholipids
Sekretorisches Immunoglobulin A (S-IgA) im Fruchtwasser ergänzt fetales Reifeprofil.