title: [Manifestations of domain organization of the Staphylococcus aureus protein A during heat denaturation of its structure].
abstract: Melting of protein A from Staphylococcus aureus has been studied in neutral medium by the methods of microcalorimetry and circular dichroism. The melting process of protein A is shown to consist of, at least, 5 independent transitions. The transition with the heat absorption maximum at 38 degrees is ascribed to the melting of the C-terminal domain of protein A. The analysis of amino acid sequences has shown the existence of structural basis for differences in heat stability of the Fc-binding domains of protein A.
mesh_terms: D000595:Amino Acid Sequence; D006358:Hot Temperature; D011487:Protein Conformation; D011489:Protein Denaturation; D013205:Staphylococcal Protein A
chemical_list: D013205:Staphylococcal Protein A
vernacular_title: Proiavlenie domennoĭ organizatsii belka A Staphylococcus aureus pri teplovom razrushenii ego struktury.