title: Wound healing in sarcoma-bearing rats: tumor effects on cutaneous and deep wounds.
abstract: Many surgeons think that cancer causes a higher incidence of wound complications. Wound healing was examined in a cutaneous and deep model in control and sarcoma-bearing rats to evaluate this concept. In a dorsal incisional wound, a significant decrease in wound breaking strength was observed from 19 days after tumor implantation onward. The amount of the breaking strength deficit increased with the size of tumor and the day post-tumor implant. In a deeper wound chamber, hydroxyproline levels, 3H-thymidine incorporation into DNA, histology, and collagen types were examined, and tumor produced no significant change in any parameter. The presence of tumor appeared to inhibit wound healing in cutaneous wounds but had no apparent effect on deeper wounds. This difference in healing in the two wound models is important to surgical oncologists. Because there is no demonstrable tumor-induced healing deficit in deep wounds, cancer-bearing organisms probably still heal these wounds normally.
mesh_terms: D000818:Animals; D003094:Collagen / Q000032:analysis; D004247:DNA / Q000096:biosynthesis; D006909:Hydroxyproline / Q000032:analysis; D008297:Male; D008748:Methylcholanthrene; D051381:Rats; D011916:Rats, Inbred F344; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000503:physiopathology*; D012867:Skin / Q000293:injuries*; D013718:Tensile Strength; D014945:Wound Healing
chemical_list: D008748:Methylcholanthrene; D003094:Collagen; D004247:DNA; D006909:Hydroxyproline