title: Inactivation of sarin and soman by cyclodextrins in vitro.
abstract: Cyclodextrins catalyzed the inactivation of sarin and soman but did not inactivate tabun and VX. Furthermore, sarin and soman showed greater affinity for beta-cyclodextrin than for alpha- or gamma-cyclodextrins. Thus beta-cyclodextrin appears to be an attractive starting material for the preparation of a catalyst able to inactivate sarin and soman more effectively. Such a catalyst might contribute to improving the therapy of poisoning caused by these two nerve agents.
mesh_terms: D003505:Cyclodextrins / Q000494:pharmacology*; D003912:Dextrins / Q000494:pharmacology*; D007700:Kinetics; D010755:Organophosphates / Q000037:antagonists & inhibitors; D009943:Organophosphorus Compounds / Q000037:antagonists & inhibitors*; D009946:Organothiophosphorus Compounds / Q000037:antagonists & inhibitors; D012524:Sarin / Q000037:antagonists & inhibitors*; D012999:Soman / Q000037:antagonists & inhibitors*; D013213:Starch / Q000494:pharmacology*; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; D047408:gamma-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D003912:Dextrins; D010755:Organophosphates; D009943:Organophosphorus Compounds; D009946:Organothiophosphorus Compounds; D012524:Sarin; D012999:Soman; D013213:Starch; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; D047408:gamma-Cyclodextrins; C009680:VX-agent; C031215:betadex; C023792:gamma-cyclodextrin; C009374:tabun; C032613:alpha-cyclodextrin