Arylbiguanides and dihydro-s-triazines as potential hypotensive agents.
Series of dihydrotriazines and arylbiguanides were synthetized and tested for their hypotensive effect. Compounds I and II in doses corresponding to 0.2 of their LD50 produced small hypotension. The biguanides exerted the hypotensive effect when given in a dose of 0.05 of their LD50, but the effect was weaker than that of aminophylline.
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001645:Biguanides / Q000138:chemical synthesis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000959:Antihypertensive Agents; D001645:Biguanides; D014227:Triazines