[The role of major histocompatibility complex genes in the reaction of macrophages and thymocytes during induction of T-effectors of the graft vs host reaction. III. Effect of antisera against H-2 complex antigens on the realization of the process].
The data are presented on the influence of antisera to different products of the histocompatibility gene complex on the interaction between macrophages and thymocytes during the formation of T-cell GVH effectors. The intensity of the local GVH reaction was evaluated by the index of the lymph nodes enlargement. The close physical contact between cells was necessary for the induction of T-effectors GVH. Treatment of macrophages or thymocytes with anti-H-2 and anti-H-2K antibodies, prior to the beginning of combined incubation, or addition of these antisera to the cultural media suppressed the formation of T-cell inducing GVH. Anti-H-2 I and anti-H-2 D sera did not affect the formation of GVH T-effectors.
D000818:Animals; D006087:Graft vs Host Reaction; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology*; D007106:Immune Sera / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology*; D008285:Major Histocompatibility Complex; D051379:Mice; D008808:Mice, Inbred CBA
D006183:H-2 Antigens; D007106:Immune Sera
Uchastie genov glavnogo kompleksa gistosovmestimosti v reaktsii vzaimodeĭstviia makrofagov s timotsitami pri induktsii T-éffektorov reaktsii transplantat protiv khoziaina. Soobshchenie III. Vliianie antisyvorotok k antigenam H-2 kompleksa na realizatsiiu protsessa.