Ketone-body metabolism after surgical stress or partial hepatectomy. Evidence for decreased ketogenesis and a site of control distal to carnitine palmitoyltransferase I.
Rats were subjected to laparotomy, or laparotomy and partial hepatectomy, at 0-48 h before administration of water or medium-chain-length triacylglycerol, having been starved post-operatively. Functional hepatectomies were performed at intervals after the intragastric load. Blood ketone-body concentrations after medium-chain triacylglycerol administration and/or functional hepatectomy of these rats were compared with values obtained in starved control rats. Decreased ketonaemia in response to medium-chain triacylglycerol was observed for up to 48 h after partial hepatectomy and at 1 and 2 h after laparotomy, but not at 24 or 48 h after laparotomy. Rates of ketone-body clearance after functional hepatectomy were unaffected by prior laparotomy or partial hepatectomy. Ketonaemia after medium-chain-triacylglycerol administration was only partially blocked by inhibition of CPT I (carnitine palmitoyltransferase I). The results demonstrate sustained effects of partial hepatectomy and short-term effects of surgical stress to decrease ketonaemia via inhibition of ketogenesis at site(s) distal to CPT I.
D000217:Acyltransferases / Q000378:metabolism*; D000818:Animals; D002334:Carnitine O-Palmitoyltransferase / Q000378:metabolism*; D005260:Female; D006498:Hepatectomy; D007657:Ketone Bodies / Q000097:blood*; D008099:Liver / Q000378:metabolism; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000097:blood / Q000378:metabolism; D013312:Stress, Physiological / Q000097:blood / Q000378:metabolism*; D014280:Triglycerides / Q000494:pharmacology
D007657:Ketone Bodies; D014280:Triglycerides; D000217:Acyltransferases; D002334:Carnitine O-Palmitoyltransferase