Evidence for humoral immunodepression in NO2-exposed mice: influence of food restriction and stress.
The effects of food restriction or 20 ppm NO2 exposure on humoral immunity were investigated in normal and adrenalectomized C57Bl/6 mice. The thymic and splenic weights of sham-operated mice were similarly diminished after 4 days of NO2 exposure or 4 days of food depletion. The responses of corresponding adrenalectomized mice were less depressed. Undernutrition induced lymphoid organ involution and corticosteroids were partly involved. Plaque-forming cells (PFC) per spleen and per 10(6) cells were markedly depressed after 4 days of NO2 exposure, but less so after food deprivation. The same significant suppression of PFC was observed in adrenalectomized groups. Depression of humoral immunity was independent of stress-induced endogenous steroids. Moreover, NO2 had a specific effect on humoral immunodepression, food restriction being an associated factor.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D005260:Female; D005508:Food Deprivation; D051379:Mice; D008810:Mice, Inbred C57BL; D009585:Nitrogen Dioxide / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects; D013312:Stress, Physiological / Q000276:immunology*; D013950:Thymus Gland / Q000187:drug effects
D009585:Nitrogen Dioxide; D003345:Corticosterone