Pathogenesis of adenocarcinoma complicating ureterosigmoidostomy. Experimental observations.
Columnar metaplasia, dysplasia, and adenocarcinoma occurred in patches of bladder epithelium exposed to the fecal stream in rats. This suggests that such tumors complicating ureterosigmoidostomy may arise from ureteric epithelium, and that urine is not essential for their development.
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D012809:Colon, Sigmoid / Q000601:surgery; D003125:Colostomy / Q000009:adverse effects* / Q000379:methods; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D005243:Feces; D008297:Male; D008679:Metaplasia / Q000473:pathology; D051381:Rats; D014513:Ureter / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000473:pathology*