Prevention of gastric mucosal lesions following aortic cross-clamping.
Stress ulceration is frequently encountered after cardiovascular surgery. In this study of 32 male baboons, severe gastric ischaemia was used to produce gastric stress lesions. The occurrence of these lesions was reduced by allopurinol (P = 0.03) and completely prevented by the combination of allopurinol with superoxide dismutase (P = 0.004). A shorter ischaemic period also reduced the number of lesions (P = 0.02). Concurrent with the stress lesion formation, there was a fall in mucosal glutathione and oxidized glutathione levels (P less than 0.05).
D000493:Allopurinol / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects; D007511:Ischemia / Q000150:complications; D008297:Male; D010215:Papio; D010437:Peptic Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000209:etiology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000627:therapeutic use
D000493:Allopurinol; D013482:Superoxide Dismutase