Induction of plasma cell tumours with 2,6,10,14-tetramethylpentadecane (pristane) and paraffin oil (paraffinum perliquidum) in BALB/c mice simultaneously exposed to sustained antigenic stimulation with bovine serum albumin (BSA).
Plasmacytomas were readily induced in BALB/c mice by three bimonthly i.p. injections of 0.5 ml pristane or paraffin oil. Additionally, two groups of mice were simultaneously given a prolonged antigenic stimulation with bovine serum albumin (BSA). The tumour incidence found in mice treated with pristane and BSA (75%) was higher than the plasmacytoma incidence in mice subjected to paraffin oil and BSA inoculations (53.7%, p = 0.05). The sustained antigenic stimulation with BSA had no effect on cumulative plasmacytoma incidence.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D007114:Immunization / Q000379:methods; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D008899:Mineral Oil / Q000633:toxicity*; D009821:Oils / Q000633:toxicity*; D010232:Paraffin; D010954:Plasmacytoma / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D012710:Serum Albumin, Bovine / Q000276:immunology*; D013729:Terpenes / Q000633:toxicity*; D013997:Time Factors
D000941:Antigens; D002273:Carcinogens; D009821:Oils; D013729:Terpenes; C009042:pristane; D012710:Serum Albumin, Bovine; D010232:Paraffin; C015418:paraffin oils; D008899:Mineral Oil