title: Secretory component-dependent binding of immunoglobulin A in the rat, monkey and human: a comparison of intestine and liver.
abstract: The source and significance of immunoglobulin A in bile remains controversial. In the rat, and several other species, immunoglobulin A is transported through hepatocytes by a specific receptor, secretory component. In humans, immunohistochemical methods have indicated a distinct lack of receptors for immunoglobulin A on hepatocytes. Binding assays with 125I-immunoglobulin A and membranes from hepatocytes and intestinal cells of the rat display secretory component-dependent binding. Primate intestinal cells also show secretory component-specific binding of immunoglobulin A. Primate liver, on the other hand, does not show immunoglobulin A binding mediated by the polymeric immunoglobulin receptor.
mesh_terms: D000818:Animals; D001665:Binding Sites; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D007128:Immunoglobulin Fragments / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008253:Macaca mulatta; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012635:Secretory Component / Q000276:immunology / Q000378:metabolism*
chemical_list: D007071:Immunoglobulin A, Secretory; D007128:Immunoglobulin Fragments; D012635:Secretory Component