[Potentiating effect of disodium salt of 2,6-dimethyl-1,4-dihydropyridine-3,5-bis-carbonyl hydroxyacetic acid on the activity of various antitumor agents].
The disodium salt of 2,6-dimethyl-1,4-dihydropyridine-3,5-bis-carbonyl hydroxyacetic acid (I) used in the mg/kg dose decreases the cyclophosphane toxicity in mice and potentiates the cytostatic activity of cyclophosphane, 5-fluorouracil and arabinosyl cytosine against leukemia P388, murine sarcoma 37 and Walker's carcinosarcoma. Administered alone I exhibits no antitumour activity. The potentiation of the antitumour effect of drugs appears independent of the administration schedule. Biochemical evidence indicates that I does not block DNA synthesis in leukemic cells in vitro, but significantly enhances the DNA-blocking effect of cyclophosphane in the same cells in vivo.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D002478:Cells, Cultured; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004095:Dihydropyridines; D004357:Drug Synergism; D007928:Lethal Dose 50; D007941:Leukemia P388 / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D012511:Sarcoma 37 / Q000188:drug therapy / Q000378:metabolism
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D004095:Dihydropyridines; D011725:Pyridines; C052711:2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic hydroxyacetate
Potentsiiruiushchee deĭstvie dinatrievoĭ soli 2,6-dimetil-1,4-digidropiridin-3,5-bis-karboniloksiuksusnoĭ kisloty na aktivnost' nekotorykh protivoopukholevykh preparatov.