Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains.
1,2,3,4-Tetrahydroisoquinoline (TIQ) and 2-methyl-1,2,3,4-tetrahydroquinoline (2-Me-TQ) were identified for the first time by gas chromatography-mass spectrometry in the parkinsonian and normal human brains. TIQ, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), was markedly increased in the parkinsonian brain and could be an endogenous neurotoxin to induce Parkinson's disease.
D001344:Autopsy; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D007546:Isoquinolines / Q000032:analysis*; D010300:Parkinson Disease / Q000378:metabolism*; D011804:Quinolines / Q000032:analysis*; D012016:Reference Values; D044005:Tetrahydroisoquinolines
D007546:Isoquinolines; D011804:Quinolines; D044005:Tetrahydroisoquinolines; C052355:2-methyl-1,2,3,4-tetrahydroquinoline; C014843:1,2,3,4-tetrahydroisoquinoline