Pharmacological evaluation of ifosfamide and its enantiomers in laboratory animals.
Some pharmacological properties of commercial racemic ifosfamide (Holoxan) and its D- and L-enantiomers were compared in experiments on mice and rats. Although values of acute toxicity and some results of subchronic treatment revealed better parameters of L-form in comparison to racemic mixture, distinct hepatotoxic effects and thrombocytopenia noted in the course of prolonged treatment seem to be the important factors limiting therapeutic usefulness of levorotatory form.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007069:Ifosfamide / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D010528:Peristalsis / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D007069:Ifosfamide