Cyclophosphamide in allergic encephalomyelitis in chickens.
The studies concerned the effect of cyclophosphamide on immunological and biochemical indices of MBP-induced encephalomyelitis. Unlike isoprinosine, cyclophosphamide was observed to exert irregular effect. Contrary to the expected, the results obtained in some experimental systems show increased level of the parameters tested-IgG, antitrypsin and sialic acid. A suggestion has been put forward that the reason of the above phenomenon may be attributed not only to the type of drug applied but also to different course of treatment with regard to various affinity of the drug (different doses) to functionally different lymphocytes (suppressor, helper).
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002645:Chickens; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003520:Cyclophosphamide