Ruthenium ammine complexes as electron acceptors for growth stimulation by plasma membrane electron transport.
Ammineruthenium(III) complexes have been found to act as electron acceptors for the transplasmalemma electron transport system of animal cells. The active complexes hexaammineruthenium(III), pyridine pentammineruthenium(III), and chloropentaammineruthenium(III) range in redox potential (E'0) from 305 to -42 mV. These compounds also act as electron acceptors for the NADH dehydrogenase of isolated plasma membranes. Stimulation of HeLa cell growth, in the absence of calf serum, by these compounds provides evidence that growth stimulation by the transplasma membrane electron transport system is not entirely based on reduction and uptake of iron.
D000631:Aminopyridines / Q000378:metabolism*; D000818:Animals; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism*; D004563:Electrochemistry; D004579:Electron Transport; D007700:Kinetics; D009942:Organometallic Compounds / Q000378:metabolism*; D010084:Oxidation-Reduction; D012428:Ruthenium / Q000378:metabolism*; D017975:Ruthenium Compounds
D000631:Aminopyridines; D009942:Organometallic Compounds; D017975:Ruthenium Compounds; C039420:pentaamminechlororuthenium; D012428:Ruthenium; C052438:pyridine pentaamineruthenium(III)