title: The effect of serial intravenous immunoglobulin infusion on type-specific anti-pneumococcal antibodies in children.
abstract: The effect of a series of five immunoglobulin G infusions--at 3-4 week interval--on serum IgG antibody concentrations against some pneumococcal types commonly associated with acute otitis media (AOM) was studied in 11 children, 1-4 years old, suffering from recurrent AOM. Increase of specific IgG antibody concentrations was observed when the initial concentrations were low. However, once higher antibody concentrations had been achieved as a result of the treatment, subsequent infusions resulted in a decrease of the antibodies. In two children with initially high specific antibody concentrations, antibodies successively decreased in response to repeated immunoglobulin infusions.
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis* / Q000276:immunology; D000918:Antibody Specificity; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007116:Immunization, Passive; D007262:Infusions, Intravenous; D010033:Otitis Media / Q000276:immunology / Q000628:therapy*; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial