Production of a macrophage chemotactic factor by cultured jaagsiekte tumour cells.
The increase of alveolar macrophages in jaagsiekte sheep lungs is not caused by excessive surfactant production but is due to a chemotactic factor secreted by the tumor cells. This factor has a molecular mass in the region of 13 kilodaltons, is stable at 56 degrees C but labile at 100 degrees C and, being sensitive to proteases, indicates that it is a small protein molecule.
D000818:Animals; D002630:Chemotactic Factors / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology; D011648:Pulmonary Adenomatosis, Ovine / Q000276:immunology* / Q000473:pathology; D011650:Pulmonary Alveoli / Q000276:immunology / Q000473:pathology; D012756:Sheep
D002630:Chemotactic Factors