Antiarrhythmic activity of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid.
Antiarrhythmic effects of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid (BK 129) was studied in pentobarbital anesthetized dogs. The dose of 1 mg kg-1 i.v. suppressed ouabain-induced ventricular tachycardia for approx. 15 min. The minimal effective dosis was 0.72 +/- 0.09 mg kg-1 in comparison with 4.56 +/- 1.90 mg kg-1 of trimecaine and 6.80 +/- 0.86 mg kg-1 of quinidine. The doses of 1 and 2 mg kg-1 decreased ectopic activity 24-48 h after coronary artery ligation without complete suppression of extrasystoles. Epinephrine-induced arrhythmias were not prevented with the dose of 1 mg kg-1. The results demonstrate effectiveness of BK 129 in suppression of some types of arrhythmias.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001381:Azepines / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D008297:Male; D013329:Structure-Activity Relationship; D013610:Tachycardia / Q000188:drug therapy
D000889:Anti-Arrhythmia Agents; D001381:Azepines; C089290:BK 129