title: Mean geometry of the thiopeptide unit and conformational features of dithiopeptides and polythiopeptides.
abstract: The mean geometry of the thiopeptide [Ca-N-C(=S)-Ca] unit has been derived from an analysis of X-ray crystal structure data, as well as MM2 and Gaussian 80/82 calculations. The conformational flexibilities of dithiopeptides with glycl- and alanyl-side chains have been investigated by molecular mechanics. Minimum energy conformations were examined using interactive computer graphics molecular modeling techniques. Alanyl-dithiopeptide substitution within an oligopeptide results in considerable restriction of conformational freedom whereas the effect is minimal for glycyl-dithiopeptide substitution. Polyglycyl-thiopeptide adopts a left-handed three or fourfold or right-handed threefold helical structure with favorable interchain C = S...H-N hydrogen bond interactions. A poly-L-alanyl-thiopeptide prefers a left-handed threefold poly-L-proline-like helical structure.
mesh_terms: D000577:Amides; D003198:Computer Simulation; D008958:Models, Molecular; D010455:Peptides; D011487:Protein Conformation; D013854:Thioamides; D014961:X-Ray Diffraction
chemical_list: D000577:Amides; D010455:Peptides; D013854:Thioamides