Cardiac electrophysiologic actions of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid in the anesthetized dog.
Cardiac electrophysiologic effects of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid (BK 129) were studied in pentobarbital anesthetized dogs. Doses of 0.5, 1 and 2 mg kg-1 i.v. produced a dose dependent slowing down of S-A and idioventricular pacemakers, increase in atrioventricular (A-V), atrial and ventricular refractoriness, and decrease in intra-atrial, A-V and intra-ventricular conduction. Retrograde ventriculoatrial conduction was affected only slightly. In dogs with A-V blockade BK 129 suppressed norepinephrine-induced acceleration of S-A and idioventricular rhythm and intra-ventricular conductivity. These results suggest that BK 129 may be an effective agent for treating cardiac arrhythmias.
D000758:Anesthesia; D000818:Animals; D001283:Atrioventricular Node / Q000187:drug effects; D001381:Azepines / Q000494:pharmacology*; D002219:Carbamates / Q000494:pharmacology*; D004285:Dogs; D004594:Electrophysiology; D005260:Female; D006321:Heart / Q000187:drug effects*; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D012849:Sinoatrial Node / Q000187:drug effects
D001381:Azepines; D002219:Carbamates; C089290:BK 129; D009638:Norepinephrine