Floxacillin-induced cholestatic hepatitis with evidence of lymphocyte sensitization.
A severe and prolonged form of biopsy-proved cholestatic hepatitis occurred in a 45-year-old man who had received floxacillin for two weeks preceding the episode of drug-related cholestatic injury. Immunologic tests revealed evidence of in vitro sensitization to the drug as well as to the serum of a normal subject collected after ingestion of floxacillin. Floxacillin should be added to the list of drugs causing cholestatic hepatitis, most likely by an immunologic mechanism.
D000328:Adult; D002455:Cell Division / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000276:immunology; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000276:immunology; D003023:Cloxacillin / Q000031:analogs & derivatives*; D005436:Floxacillin / Q000009:adverse effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male
D005436:Floxacillin; D003023:Cloxacillin