title: Absorption, distribution and excretion of the anthelmintic praziquantel (Droncit) in rainbow trout (Salmo gairdneri R.).
abstract: Prazquantel is an anthelmintic active against trematodes and cestodes. The absorption, distribution and excretion of the drug was studied in serum, muscles, liver, bile fluid and kidneys of rainbow trout at two temperatures, 12 degrees C and 18 degrees C, after a single oral dose of 500 mg/kg body wt. A bioassay, using cercaria larvae of the trematode Diplostomum spathaceum as the test organism, was employed to measure the drug levels in tissues of the fish. The cercariae were very sensitive to praziquantel; their mobility was significantly reduced within 20 min in a 0.01 micrograms/ml solution. Praziquantel was readily absorbed from the gastrointestinal tract of the fish. Absorption was more rapid at 18 degrees C than at 12 degrees C. Only in the liver, however, did the peak values reach significantly higher levels at the higher temperature. The peak values in different tissues (10.2-31.8 micrograms/g) were reached 4-16 h after administration of the drug. The elimination of the drug from the tissues was less dependent on temperature than absorption. By 32 h p.a., 67%-96% of the maximum amounts had been eliminated from the tissues. Praziquantel was excreted partly with bile fluid and partly as water-soluble metabolites through the kidneys.
mesh_terms: D000818:Animals; D001681:Biological Assay; D007408:Intestinal Absorption; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D011223:Praziquantel / Q000378:metabolism* / Q000494:pharmacology; D012487:Salmonidae / Q000378:metabolism*; D013696:Temperature; D014018:Tissue Distribution; D014200:Trematoda / Q000187:drug effects; D014337:Trout / Q000378:metabolism*
chemical_list: D011223:Praziquantel