Pharmacokinetic parameters of 1-beta-D-arabinofuranosylcytosine (ara-C) and their relationship to intracellular metabolism of ara-C, toxicity, and response of patients with acute nonlymphocytic leukemia treated with conventional and high-dose ara-C.
D000208:Acute Disease; D000818:Animals; D001085:Arabinofuranosylcytosine Triphosphate / Q000378:metabolism; D001086:Arabinofuranosyluracil / Q000378:metabolism; D003561:Cytarabine / Q000378:metabolism* / Q000627:therapeutic use / Q000633:toxicity; D004334:Drug Administration Schedule; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D007939:Leukemia L1210 / Q000378:metabolism; D008657:Metabolic Clearance Rate; D051379:Mice; D014541:Uridine Kinase / Q000378:metabolism
D003561:Cytarabine; D001085:Arabinofuranosylcytosine Triphosphate; D001086:Arabinofuranosyluracil; D014541:Uridine Kinase