Kainic acid lesions of the cat's antero-medial hypothalamus and emotional-defensive response evoked by carbachol injection to the same loci.
Injections of carbachol (CCh) through a chronic cannula into the antero-medial hypothalamus (AMH) of the cat induced the emotional-defensive response (EDR) which was evaluated by time duration and number of growls in a 30-min experimental session. That response was examined before and after injection of kainic acid (KA) to the same loci of hypothalamus. None of KA doses employed (3 micrograms/2 microliter and 6 micrograms/2 microliter of vehicle) brought about statistically significant changes in parameters of the vocal response. The results suggest that either the AMH neuronal perikarya responsible for CCh-induced EDR, are resistant to KA, or muscarinic receptors initiating the EDR are not localized on perikarya.
D000374:Aggression / Q000187:drug effects*; D000378:Agonistic Behavior / Q000187:drug effects*; D000818:Animals; D001931:Brain Mapping; D002217:Carbachol / Q000494:pharmacology*; D002415:Cats; D004644:Emotions / Q000187:drug effects*; D005260:Female; D007032:Hypothalamus, Anterior / Q000187:drug effects*; D007033:Hypothalamus, Middle / Q000187:drug effects*; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects
D002217:Carbachol; D007608:Kainic Acid