title: The effect of amitriptyline on the central nervous system penetration of methotrexate.
abstract: The reported ability of amitriptyline to enhance the penetration of diffusion limited substances across the blood brain barrier was investigated. The CSF:plasma ratio of methotrexate in primates was not significantly altered by amitriptyline pretreatment. Nor was methotrexate plasma clearance altered.
mesh_terms: D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004347:Drug Interactions; D008253:Macaca mulatta; D008727:Methotrexate / Q000097:blood / Q000134:cerebrospinal fluid*
chemical_list: D000639:Amitriptyline; D008727:Methotrexate