[The analgesic action of clofelin administered via the cerebral ventricles and the theca medullaris spinalis].
In experiments on conscious rats it was found that clopheline (10-50 micrograms) administered intracerebroventricularly and intrathecally inhibits nociceptive shifts of arterial blood pressure and predominantly depresses segmental pain reflex in the tail-flick test. Pharmacological analysis showed that the inhibiting effect of clopheline on various manifestations of pain was due to the activation of alpha 1-adrenoceptors of the spinal cord, while in the brain the processes triggered through alpha 2-adrenoceptors play the leading role.
D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D001921:Brain / Q000187:drug effects; D003000:Clonidine / Q000008:administration & dosage*; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D009270:Naloxone / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects; D010146:Pain / Q000503:physiopathology; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012684:Sensory Thresholds / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects; D015016:Yohimbine / Q000494:pharmacology
D000700:Analgesics; D015016:Yohimbine; D009270:Naloxone; D003000:Clonidine; D011224:Prazosin
Boleutoliaiushchee deĭstvie klofelina pri vvedenii v zheludochki golovnogo mozga i pod obolochki spinnogo mozga.