[Lethal action of accelerated heavy ions on mammalian cells as affected by inhibitors of DNA synthesis. Results of experimental research].
Radiosensitivity of Chinese hamster cells exposed to 137Cs-gamma-radiation and accelerated heavy ions of 4He (L = 22 and 60 keV/micron), 12C (L = 231 keV/micron), and 20Ne (L = 690 keV/micron) was studied in standard conditions and in the presence of arabinosylcytosine and hydroxyurea. These agents were shown to exert a radiosensitizing effect in the case of gamma-radiation. The effect was less pronounced with 4He ion-radiation and was absent upon irradiation with 12C and 20Ne ions. The radiosensitivity was maximum upon irradiation with 4He ions at L = 60 keV/micron. The RBE coefficients of heavy ions under study decreased in the presence of DNA synthesis inhibitors.
D000818:Animals; D006224:Cricetinae; D003412:Cricetulus; D003561:Cytarabine / Q000494:pharmacology; D004247:DNA / Q000037:antagonists & inhibitors* / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004601:Elementary Particles; D004735:Energy Transfer; D005720:Gamma Rays; D006918:Hydroxyurea / Q000494:pharmacology; D010315:Particle Accelerators; D011836:Radiation Tolerance; D012062:Relative Biological Effectiveness; D013997:Time Factors
D003561:Cytarabine; D004247:DNA; D006918:Hydroxyurea
Letal'noe deĭstvie uskorennykh tiazhelykh ionov na kletki mlekopitaiushchikh v usloviiakh vliianiia ingibitorov sinteza DNK. Rezul'taty éksperimental'nykh issledovaniĭ.