Effects of retinoids in N-nitrosobis(2-oxopropyl)amine-treated hamsters.
The effect of feeding four synthetic retinoids was evaluated in carcinogen-treated hamsters. Syrian golden hamsters were injected with 20 mg/kg of N-nitrosobis(2-oxopropyl)amine (BOP) and then fed retinoid-supplemented diets for 39 weeks. All retinoid-treated groups grew more slowly than controls, and average survival was shorter in female retinoid-treated groups. A significant incidence of testicular atrophy was noted in male hamsters fed 2-hydroxyethylretinamide or 4-carboxyphenylretinamide. The incidence of pancreatic carcinomas was lower in 12 of 14 retinoid-fed groups than in the corresponding control groups, although the differences approached significance only in groups fed two of the retinoids--male hamsters fed N-4-propionyloxyphenylretinamide and those fed retinylidene dimedone. A low incidence of carcinoma in the control groups limits the conclusions that can be drawn from this study, but it is of note that there was no evidence of promotion.
D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D001284:Atrophy / Q000139:chemically induced; D002273:Carcinogens; D002278:Carcinoma in Situ / Q000473:pathology; D006224:Cricetinae; D004195:Disease Models, Animal; D005260:Female; D006965:Hyperplasia / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D012176:Retinoids / Q000627:therapeutic use*; D012737:Sex Factors; D013737:Testis / Q000473:pathology
D002273:Carcinogens; D009602:Nitrosamines; D012176:Retinoids; C013622:nitrosobis(2-oxopropyl)amine