Carcinogenicity of extract of airborne particles using newborn mice and comparative study of carcinogenic and mutagenic effect of the extract.
An organic extract of airborne particles collected in Tokyo and its fractions (neutral, acidic, and basic) were investigated in Ames Salmonella assays for mutagenicity and in newborn mice for carcinogenicity. Mutagenicity to TA100 and TA98 strains was detected in the whole extract, the neutral, the acidic and the basic fractions with and without metabolic activation. In the carcinogenicity test, the incidence of lung tumor was as follows: whole extract, 4/25; neutral fraction, 7/25; acidic fraction, 0/20; basic fraction, 1/11; vehicle, 2/39; and uninjected, 3/47. The neutral fraction of the extract of the airborne particles showed highly potent mutagenicity and a high incidence of lung tumors in mice.
D000236:Adenoma / Q000209:etiology; D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D008175:Lung Neoplasms / Q000209:etiology; D008223:Lymphoma / Q000209:etiology; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D010316:Particle Size
D000393:Air Pollutants