Protective immunity to progressive tumors can be induced by antigen presented on regressor tumors.
Immunization of animals with 1591-RE tumor cells, a highly immunogenic UV-induced epithelia cell tumor from C3H/HeN mice, that were haptenated with trinitrophenol (TNP) leads to protective immunity against a challenge of TNP-haptenated 3152-PRO tumor cells, a progressive highly malignant. MCA-induced fibrosarcoma from syngeneic mice. Animals that rejected TNP-1591-RE and subsequently TNP-3152-PRO tumor cells showed increased tumor-specific resistance to another challenge of 3152-PRO tumor cells, even when these fibrosarcoma cells had not been haptenated with TNP. Induction of protection required the presence of TNP-hapten groups on both 1591-RE and 3152-PRO during the initial immunization, and could be induced by immunization with other haptenated syngeneic highly immunogenic regressor tumor lines. In addition, TNP-haptenated progressor variants of the 1591-RE were ineffective in generating protection, suggesting that the immunogenicity of the haptenated tumor used for the initial immunization was a determining factor in whether or not protective immunity against the highly malignant tumor was later generated. Protection required at least two T cell types: a Lyt-1-2+ T cells, and a Lyt-1+2- T cell that also expressed I-J determinants and was Vicia villosa lectin adherent, suggesting it was not a classical helper T cell. These results suggest that presentation of a hapten by highly immunogenic tumor cells can lead to enhanced protective immunity to poorly immunogenic noncross-reactive tumors that co-express the same hapten, and rejection of these haptenated poorly immunogenic tumors leads to enhanced protection against a subsequent challenge of the same, but not noncross-reactive progressor tumors.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D005260:Female; D005354:Fibrosarcoma / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D006084:Graft Rejection; D006241:Haptens / Q000276:immunology; D007114:Immunization; D007116:Immunization, Passive; D037102:Lectins / Q000378:metabolism; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009381:Neoplasms, Radiation-Induced / Q000276:immunology; D037121:Plant Lectins; D014301:Trinitrobenzenes / Q000276:immunology; D014466:Ultraviolet Rays
D000951:Antigens, Neoplasm; D006241:Haptens; D037102:Lectins; D037121:Plant Lectins; D014301:Trinitrobenzenes; C042242:Vicia lectins; D008748:Methylcholanthrene