Alteration of erythrocytes by reduced species of oxygen generated in hypoxic rat liver during perfusion.
Activated species of oxygen produced in the hypoxic rat liver leave the cells and attack the membrane of circulating erythrocytes. Therefore the metabolic and structural changes of red blood cells may be appropriate indicators of an oxidative loading in tissues. The circulating erythrocytes exert a profound protective, "radical scavenger effect" on the liver tissue.
D000818:Animals; D004912:Erythrocytes / Q000378:metabolism*; D005609:Free Radicals; D006461:Hemolysis; D000860:Hypoxia / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D009996:Osmotic Fragility; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D005609:Free Radicals; D010100:Oxygen