title: [Acute leukemia in Fanconi's anemia. Report of a patient and review of the literature].
abstract: A case is reported of a 7 years old boy with Fanconi's Anemia (FA). The aplastic anemia has been treated with androgens. Six years after the confirmation of the diagnosis FA a (pre-)leukemia occurred. Because of the known complications of cytostatics in FA and the bad prognosis, the leukemia has not been treated. The boy died 4 months later. An overview of the literature shows 31 patients with acute non-lymphocytic leukemia in FA, of which the clinical course, chromosomal investigations and therapy are discussed.
mesh_terms: D000208:Acute Disease; D000741:Anemia, Aplastic / Q000150:complications*; D001773:Blood Cells / Q000032:analysis; D001853:Bone Marrow / Q000032:analysis; D002648:Child; D005199:Fanconi Anemia / Q000097:blood / Q000150:complications*; D006801:Humans; D008297:Male; D011289:Preleukemia / Q000097:blood / Q000150:complications*
vernacular_title: Acute leukemie bij Fanconi anemie. Beschrijving van één patiënt en overzicht van de literatuur.