[Polyethylene oxide-based artificial antigens. An experimental study of the kinetics of the distribution of polyethylene oxide derivatives].
125I-labeled derivatives of iodaryl-polyethylene oxide with mol. wt. equal to 3 X 10(3), containing and not containing dinitrophenyl (DNP) residues (haptens), were obtained. The capacity for anti-DNP response was shown to be unaffected by the presence of the iodaryl group. The pharmacokinetics of both derivatives of polyethylene oxide were studied in experiments on noninbred white rats receiving these derivatives intravenously in doses of 0.53-0.80 mg/kg. These experiments revealed the following differences in the pharmacokinetics of the derivatives under study: the presence of the DNP group led to an increase in the level of polymer fixation in the body of the animals, particularly in their blood, liver and spleen. Differences in the content of radioactive substances in other organs were not statistically significant.
D000818:Animals; D000941:Antigens / Q000378:metabolism*; D005260:Female; D007457:Iodine Radioisotopes; D007700:Kinetics; D008433:Mathematics; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011092:Polyethylene Glycols / Q000378:metabolism*; D051381:Rats; D013329:Structure-Activity Relationship; D013997:Time Factors; D014018:Tissue Distribution; D014614:Vaccines, Synthetic / Q000378:metabolism*
D000941:Antigens; D007457:Iodine Radioisotopes; D014614:Vaccines, Synthetic; D011092:Polyethylene Glycols
Iskusstvennye antigeny na osnove polietilenoksida. Eksperimental'noe izuchenie kinetiki raspredeleniia proizvodnykh polietilenoksida.