Syntheses and antibacterial activity of new N-halamine compounds.
The syntheses of three new N,N'-dihalamine compounds in the class of tetramethylimidazolidinones are described. The stabilities and disinfection efficacies against Staphylococcus aureus of the compounds in water solution are compared with those for 3-chloro-4,4-dimethyl-2-oxazolidinone which has been studied extensively in recent years in these laboratories and elsewhere. The new compounds exhibit considerable promise as general-purpose disinfectants, particularly in applications for which long-term stability is necessary.
D004202:Disinfectants / Q000138:chemical synthesis*; D004355:Drug Stability; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014871:Water Microbiology
D004202:Disinfectants; D007093:Imidazoles