Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.
Humoral hypercalcemia of malignancy is a common paraneoplastic syndrome which is characterized by hypercalcemia resulting from secretion by tumors of a circulating bone-resorbing factor. Evidence suggests that in many instances this factor is an adenylate cyclase-stimulating protein which shares features with, but is distinct from, parathyroid hormone (PTH). The current report describes the purification to homogeneity from a humoral hypercalcemia of malignancy-associated tumor of a novel, basic, highly potent PTH-like adenylate cyclase-stimulating protein. This factor differs from previously described PTH-like factors with respect to size, amino acid composition, and specific activity.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000596:Amino Acids / Q000032:analysis; D001943:Breast Neoplasms / Q000150:complications* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology* / Q000378:metabolism; D007525:Isoelectric Focusing; D008970:Molecular Weight; D010084:Oxidation-Reduction; D010281:Parathyroid Hormone / Q000302:isolation & purification* / Q000494:pharmacology
D000596:Amino Acids; D010281:Parathyroid Hormone; D000262:Adenylyl Cyclases