title: Use of plasmapheresis and chemotherapy for treatment of monoclonal gammopathy associated with Ehrlichia canis infection in a dog.
abstract: Monoclonal gammopathy associated with Ehrlichia canis infection was diagnosed in a German Shepherd Dog. The dog was treated by use of chemotherapy and tetracycline and by plasmapheresis. The dog tolerated plasmapheresis and long-term drug therapy well, and clinical signs resolved over a 90-day period. The monoclonal gammopathy resolved after treatment, but specific antibody to E canis indicated suppression followed by a rebound to the initial high titer.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000628:therapy; D004285:Dogs; D004536:Ehrlichia; D005260:Female; D006942:Hypergammaglobulinemia / Q000662:veterinary*; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications / Q000188:drug therapy / Q000628:therapy / Q000662:veterinary*; D010956:Plasmapheresis / Q000662:veterinary*; D012288:Rickettsiaceae Infections / Q000150:complications / Q000188:drug therapy / Q000628:therapy / Q000662:veterinary*; D013752:Tetracycline / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D013752:Tetracycline