Immunobiological and antiinflammatory properties of 1-phenylo-2-thioxo-3-diethylo-aminoethylo-4-ox o-7-methylpyrimido- [4,5-c]-pyrimidine hydrochloride (compound I).
Immunological and pharmacological properties of 1-phenylo-2-thioxo-3-diethylo-aminoethylo-4-oxo- 7-methylpyrimido [4,5-c]-pyrimidine hydrochloride were evaluated. The preparation was observed to exert immunotropic, predominantly suppressive effect as well as nonspecific antiinflammatory effect. This was accompanied by hardly perceptible central component and slight, reversible effect on the circulatory system. The trials to elucidate mechanism of activity of the immunotropic preparation revealed that it attacked immunologically committed cells. However, it does not act on suppressor cells.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004285:Dogs; D006087:Graft vs Host Reaction; D006168:Guinea Pigs; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006967:Hypersensitivity; D007165:Immunosuppression Therapy; D007249:Inflammation; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D010587:Phagocytosis / Q000187:drug effects; D011743:Pyrimidines / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012397:Rosette Formation
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011743:Pyrimidines