Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in biopsy material.
Linoleic acid (18:2(9,12)) and its diene-conjugated isomer (18:2(9,11)) were measured in 65 cervical biopsy samples. Both the 18:2(9,11) concentration and the 18:2(9,11)/18:2(9,12) molar ratio showed highly significant differences between the normal and precancerous groups. Both showed a further significant increase in 4 invasive carcinomas. The findings in histologically normal areas from organs with precancer correlated significantly with the results in the precancerous lesions.
D001706:Biopsy; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005609:Free Radicals; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000032:analysis*; D044243:Linoleic Acids, Conjugated; D011230:Precancerous Conditions / Q000175:diagnosis*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*
D005609:Free Radicals; D008041:Linoleic Acids; D044243:Linoleic Acids, Conjugated; C046938:9,11-linoleic acid; D019787:Linoleic Acid