Susceptibility of Torulopsis glabrata in the presence of six antifungal agents determined by comparison of growth at several pHs.
We describe a method using an automated system whereby fungistatic activities can be determined in several conditions. The process was adapted to Torulopsis glabrata, and it showed that benzalkonium chloride, chlorhexidine gluconate, and thimerosal preserve fungistatic activities in acidic medium, whereas acidification reduces the activity of povidone iodine and poloxamer.
D000935:Antifungal Agents / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000494:pharmacology; D001550:Benzamidines / Q000494:pharmacology; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D011060:Poloxalene / Q000494:pharmacology; D011206:Povidone-Iodine / Q000494:pharmacology; D013849:Thimerosal / Q000494:pharmacology
D000935:Antifungal Agents; D001548:Benzalkonium Compounds; D001550:Benzamidines; D013849:Thimerosal; C018961:hexamidine; D011206:Povidone-Iodine; D011060:Poloxalene; C010882:chlorhexidine gluconate; D002710:Chlorhexidine