title: [Activation of the complement system during hemodialysis].
abstract: One of the adverse effects of haemodialysis is activation of the complement system occurring at the contact of blood with the dialyser membrane. In vitro conditions it was found by means of a modified method of registering haemolitic complement activity pre- and post-incubation with the membrane that the activation of complement in a given blood donor depends both on the inherent complement reactivity and on the surface physico-chemical qualities. The contribution of each component was estimated by means of the coefficient of spontaneous speed (kspont) and of induced speed (kind) of complement activation. The comparison of the results of the complement system activation in vivo (in 9 dialysed patients) with the in vitro results made it possible to use the designed kinetic model in prognostication of the complement system of a given patient subjected to haemodialysis.
mesh_terms: D002476:Cellophane; D003167:Complement Activation; D006801:Humans; D066298:In Vitro Techniques; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000628:therapy; D008567:Membranes, Artificial; D008768:Methylmethacrylates; D011379:Prognosis; D006435:Renal Dialysis / Q000009:adverse effects
chemical_list: D008567:Membranes, Artificial; D008768:Methylmethacrylates; D002476:Cellophane
vernacular_title: Aktivatsiia sistemy komplementa pri gemodialize i vozmozhnost' ee prognozirovaniia.