title: Age-related changes in testicular development and reproductive endocrinology associated with aflatoxicosis in the male chicken.
abstract: A study was conducted to investigate endocrine and testicular changes in the male chicken associated with the ingestion of 10 or 20 ppm aflatoxin at 3 different stages of development. Weekly body weight gain, absolute and relative combined testes weights, and plasma testosterone concentrations were reduced in aflatoxin-fed males as compared to controls, with the greatest differences seen at 12 wk of age. The effect of dietary aflatoxin on levels of plasma luteinizing hormone (LH) was dependent on age at exposure. Concentrations of plasma LH in 6-wk-old control males were significantly higher than in aflatoxin-fed birds, whereas no treatment differences were observed in older males. Additionally, few changes were observed in static levels of monoamines in any of the brain regions assayed, regardless of age at exposure. The delay in peak levels of LH, as well as the suppression of plasma testosterone and testicular weight, indicate a possible delay in the onset of sexual maturation associated with aflatoxicosis in this species.
mesh_terms: D000348:Aflatoxins / Q000494:pharmacology* / Q000633:toxicity; D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002645:Chickens / Q000254:growth & development*; D004298:Dopamine / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D012098:Reproduction / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism; D012741:Sexual Maturation / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000254:growth & development*; D013739:Testosterone / Q000097:blood
chemical_list: D000348:Aflatoxins; D012701:Serotonin; D013739:Testosterone; D007986:Luteinizing Hormone; D004298:Dopamine; D009638:Norepinephrine