Erythroblast multinuclearity in bone marrow and spleen. Congenital dyserythropoietic anemia-like abnormalities without functional evidence of dyserythropoiesis.
A dyserythropoietic syndrome with coincidental immune thrombocytopenia seen during pregnancy is discussed. The morphological and serological results in this case most resemble type II congenital dyserythropoietic anemia. However, functional evidence of dyserythropoiesis was absent and the patient was not anemic. Splenectomy was performed for the resistant thrombocytopenia and microscopic examination of the spleen showed evidence of extramedullary dyserythropoiesis. The significance of these findings is discussed with regard to the spectrum of recognized dyserythropoietic disorders and the unusual discrepancy between the abnormal morphology and the absence of functional dyserythropoiesis.
D000328:Adult; D000742:Anemia, Dyserythropoietic, Congenital / Q000097:blood / Q000175:diagnosis / Q000473:pathology*; D000745:Anemia, Hemolytic, Congenital / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology*; D002467:Cell Nucleus / Q000648:ultrastructure; D003937:Diagnosis, Differential; D004900:Erythroblasts / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000175:diagnosis / Q000473:pathology*; D013154:Spleen / Q000473:pathology*