title: O-carbamoylsalicylates: agents for modification of hemoglobins.
abstract: To combine the attractive features of cyanate and of O-acetylsalicylate as hemoglobin-modifying agents we have prepared carbamoylsalicylate. This compound is a close analogue of aspirin and also resembles a masked cyanate. O-Carbamoylsalicylate and some related carbamates modify hemoglobin substantially, even at 5 mM concentration.
mesh_terms: D000986:Antisickling Agents; D002219:Carbamates / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006454:Hemoglobins / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D012459:Salicylates / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000986:Antisickling Agents; D002219:Carbamates; D006454:Hemoglobins; D012459:Salicylates; D010100:Oxygen