title: Comparison of the effect of antidepressant drugs on arrhythmias in the isolated rat heart subjected to myocardial ischaemia and reperfusion.
abstract: Rat isolated hearts were perfused according to the Langendorff's method. The hearts were prelabelled with 3H-noradrenaline (3H-NA) and the left coronary artery was occluded during 10 min. The liberation of 3H-NA and the development of ventricular arrhythmias were investigated during ischaemia and the following reperfusion period. In control preparations, reperfusion was followed by ventricular fibrillation and a sudden release of radioactivity in the coronary effluent. Antidepressants such as imipramine, metapramine, mianserin and nomifensine prevented reperfusion arrhythmias in a concentration-dependent manner and caused bradycardia. Amineptine, however, was ineffective in preventing reperfusion arrhythmias even in a high concentration, this agent did not decrease heart rate. Nevertheless none of the antidepressants changed the rate of liberation of 3H-NA during the ligation and reperfusion periods. A quinidine like action seems the most appropriate explanation for the cardiac effects of these antidepressant drugs.
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000517:prevention & control*; D003327:Coronary Disease / Q000150:complications*; D003984:Dibenzazepines / Q000627:therapeutic use; D003986:Dibenzocycloheptenes / Q000627:therapeutic use; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D008803:Mianserin / Q000627:therapeutic use; D009627:Nomifensine / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000889:Anti-Arrhythmia Agents; D000928:Antidepressive Agents; D003984:Dibenzazepines; D003986:Dibenzocycloheptenes; D009627:Nomifensine; D008803:Mianserin; C011597:amineptin; C012677:metapramine; D007099:Imipramine