[Peroxidation of biomembrane lipids and its enzymatic regulation during aging in the rat].
Measurement of the intensity of chemiluminescence and accumulation of the peroxidation products detected in the reaction with thiobarbituric acid (TBA-active products) has shown that with the ageing of rats the intensity of peroxidation of biomembranes' lipids gets lower in the liver and heart homogenates and tends to decrease in the brain homogenates. A strict correlation is established to exist between the level of TBA-active products and the chemiluminescence intensity independent of the age, organ and the method of initiation of lipids' peroxidation and its intensity. Considerable age changes in the rate of lipids' peroxidation in the liver and heart homogenates may be associated with an increase in the activity of a number of such antioxidant enzymes as superoxide dismutase, glutathione peroxidase, glutathione transferase and catalase in the postnatal ontogenesis of rats.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D049449:Luminescence; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism
D008054:Lipid Peroxides; D008563:Membrane Lipids; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase
Perekisnoe okislenie lipidov biomembran i ego fermentativnaia reguliatsiia pri starenii krys.