Stimulation of prostaglandin E production in superfused human amnion by human amniotic fluid.
We studied the effects of human amniotic fluid (HAF) on the production of prostaglandin E (PGE) by amnion tissues using a technique of fresh-tissue superfusion. The production of PGE was linear with time for 4.5 h by amnion tissues superfused either with medium alone or with medium plus HAF (30% v/v). Tissues superfused with medium plus HAF produced significantly more PGE than tissues superfused with medium alone. Additionally, amnion tissue obtained at cesarean section, prior to labor, displayed a greater responsiveness to HAF than did amnion obtained after spontaneous labor.
D000650:Amnion / Q000378:metabolism*; D000653:Amniotic Fluid / Q000502:physiology*; D002585:Cesarean Section; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011458:Prostaglandins E / Q000096:biosynthesis*
D011458:Prostaglandins E