[In vitro study of the cytotoxicity and selectivity of 7 beta-hydroxycholesterol].
Since the mid seventies different groups of scientists have reported unanimously a cytotoxic effect of 7 beta-OH-cholesterol on tumor cell cultures. The effect on normal soma cells and a therewith associated possible tumor-specific selectivity however, is contrarily described. The present results confirm the cytotoxic effect of the substance against tumor cells. Further a high suppression in cell function of dividing soma cells by 7 beta-OH-cholesterol could be found. Thus the substance does not fulfill the hope for a selective drug in tumor therapy.
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006888:Hydroxycholesterols / Q000494:pharmacology*; D009369:Neoplasms
D006888:Hydroxycholesterols; C011724:cholest-5-en-3 beta,7 alpha-diol
In-vitro-Untersuchung der Zytotoxizität und Selektivität von 7 beta-OH-Cholesterol.