High-performance liquid chromatographic determination of nafimidone and its major metabolite nafimidone alcohol in human plasma and urine.
A rapid, sensitive and selective method for the determination in plasma and urine of nafimidone, a new antiepileptic drug, and its major metabolite, nafimidone alcohol, has been developed which uses a high-performance liquid chromatographic system and a fluorescence detector for nafimidone or ultraviolet detector for nafimidone alcohol. The detection limits for nafimidone and nafimidone alcohol are 5.0 and 12.5 ng/ml, respectively.
D000927:Anticonvulsants / Q000032:analysis* / Q000097:blood / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007093:Imidazoles / Q000032:analysis*; D007700:Kinetics; D009278:Naphazoline / Q000031:analogs & derivatives / Q000032:analysis* / Q000097:blood / Q000652:urine
D000927:Anticonvulsants; D007093:Imidazoles; C052468:nafimidone alcohol; D009278:Naphazoline; C038671:nafimidone