title: [Ultrastructure of the ovaries of guinea pigs immunized with preparations of purified and unpurified antigens of the zona pellucida of xenogenic ova].
abstract: The state of the guinea pig ovaries has been studied electron microscopically in 8-15 and 30 days after an active immunization course with purified and non-purified antigens of the ovum zona pellucida has been completed. Both antigens produce early total morphofunctional rearrangements in the ovaries: increasing process of follicular atresia and disturbance of folliculogenesis, accompanied with hyperplasia of the interstitial tissue. The non-purified antigen produces more pronounced changes in the cavitary follicles: disturbances of cellular communications, barrier function of the follicular epithelium becomes weak, its respiratory, plastic and secretory function changes with subsequent distension of the follicle and with an enhanced development of connective tissue in its membranes. Injection of the purified antigen results in progressive atresia of the cavitary follicles and in hyperplasia of the interstitial tissue. Reduction of the corpus luteum is not observed.
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology* / Q000302:isolation & purification; D005260:Female; D006168:Guinea Pigs; D007114:Immunization; D008854:Microscopy, Electron; D009940:Organoids / Q000648:ultrastructure; D010053:Ovary / Q000276:immunology* / Q000648:ultrastructure; D010063:Ovum / Q000276:immunology*; D015044:Zona Pellucida / Q000276:immunology*
chemical_list: D000941:Antigens
vernacular_title: Ul'trastruktura iaichnikov morskikh svinok, immunizirovannykh preparatami ochishchennykh i neochishchennykh antigenov prozrachnoĭ zony ksenogennykh iaĭtsekletok.