title: Histochemical investigation of cervical intraepithelial neoplasia.
abstract: An enzyme histochemical method and histomorphological examination were applied in the cases of 37 patients with cytological atypia. Good agreement was found between the presence of aberrant glucose-6-phosphate dehydrogenase (G-6-PD) activity (metabolic atypia) and histopathologically demonstrable dysplasia. Only three women with metabolic atypia showed a normal histopathological picture. The results suggest that enzyme histochemistry may also be a valuable supplement to histopathology in the diagnosis of cervical neoplastic changes.
mesh_terms: D000293:Adolescent; D000328:Adult; D002278:Carcinoma in Situ / Q000201:enzymology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D008875:Middle Aged; D009245:NADH Dehydrogenase / Q000378:metabolism; D009252:NADPH Dehydrogenase / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism; D002578:Uterine Cervical Dysplasia / Q000201:enzymology*; D002583:Uterine Cervical Neoplasms / Q000201:enzymology*
chemical_list: D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D009252:NADPH Dehydrogenase; D009245:NADH Dehydrogenase