[Bombesin reduces body temperature chiefly by increasing peripheral blood flow].
Bombesin, some of its fragments and analogues, being injected intracerebroventricularly, induce rapid decline in body temperature. The active fragment of bombesin--C-terminal nonapeptide--induced a 25% depression of oxygen consumption in cold-exposed rabbits, no changes in the shivering thermogenesis, and a 3.5--5.0-fold increase of ear blood vessels section area accompanied by a gain in linear velocity of blood flow. The peripheral blood flow seems to be the main effector of the bombesin-induced hypothermia.
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects*; D001839:Bombesin / Q000494:pharmacology*; D002682:Chinchilla; D003080:Cold Temperature; D004431:Ear, External / Q000098:blood supply; D004576:Electromyography; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D014665:Vasodilator Agents
D010446:Peptide Fragments; D014665:Vasodilator Agents; C030475:bombesin nonapeptide; D001839:Bombesin
Bombezin snizhaet temperaturu tela glavnym obrazom putem uvelicheniia perifericheskogo krovotoka.