The effect of tick-borne fever on metabolism and renal clearance of sulfadimidine in goats.
The tick-borne fever (TBF) model was used to study the effect of fever on the metabolism of sulfadimidine in goats. During TBF the elimination half-lives were prolonged, and the renal clearance values of sulfadimidine and the majority of its metabolites were markedly diminished compared with those in the uninfected state. During TBF the steady-state levels of the hydroxy metabolites were markedly increased. TBF reduced the extent of hydroxymethylation of the pyrimidine side chain; TBF did not affect acetylation of sulfadimidine. In one goat a progressive accumulation of the metabolites was noticed.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D004536:Ehrlichia; D006041:Goats / Q000378:metabolism*; D007700:Kinetics; D012288:Rickettsiaceae Infections / Q000378:metabolism / Q000662:veterinary*; D013418:Sulfamethazine / Q000009:adverse effects / Q000378:metabolism* / Q000652:urine
D013418:Sulfamethazine; D003404:Creatinine