Effects of d,l-propranolol on apomorphine induced stereotyped behavior in rats.
The effects of d,l propranolol on stereotyped behavior induced by apomorphine administration was studied quantitatively. d,l Propranolol caused a 2.5 leftward displacement of the control dose-response curve constructed to apomorphine-induced stereotypy; the ED50 for apomorphine was reduced from 1.87 +/- 0.38 to 0.74 +/- 0.17. The potentiation was dependent on both d,l-propranolol and apomorphine doses. Results are discussed in the light of a possible interference of the central noradrenergic systems with the expression of dopaminergic-induced stereotyped behavior.
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*
D011433:Propranolol; D001058:Apomorphine