[Response to influenza vaccine in uremic patients: relation to erythrocyte magnesium and the value of a second injection].
Humoral response to influenza vaccination being variable in uremic patients and being negatively correlated to red blood cell magnesium (RBC Mg) in non-uremic subjects, RBC Mg as well as plasma concentration of Mg were measured simultaneously with the antibodies titers after 1 and 2 injections of influenza vaccine in 21 non-uremic subjects and 47 patients on chronic hemodialysis. The RBC Mg and plasma Mg (MgP) were significantly higher in the dialysed patients (74 +/- 12 mg/l; 25 +/- 8 mg/l) than in the non-uremic subjects (54 +/- 5 mg/l; 19.4 +/- 1.5 mg/l). Furthermore, in the uremics RBC Mg was correlated to PMg whereas such a correlation was absent in the non-uremic patients. The humoral response of the uremic patients is depressed and becomes comparable to that of the non-uremic subjects after 1 injection only after 2 injections. In the uremic patients, the depressed humoral response is associated with higher RBC Mg (greater than 70 mg/l). The humoral response to influenza vaccine is depressed in uremic patients who have either the HBs antigen or no response to the hepatitis B vaccine but no link has been found between this immune status against the hepatitis B and RBC Mg. In conclusion, the humoral response of the uremic patients to influenza vaccine is depressed so that a second injection is necessary to give them sufficient protection.
D000328:Adult; D004912:Erythrocytes / Q000032:analysis*; D005260:Female; D006510:Hepatitis B Antibodies; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D007117:Immunization, Secondary; D007252:Influenza Vaccines / Q000008:administration & dosage*; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood; D013054:Spectrophotometry, Atomic; D014511:Uremia / Q000097:blood*; D014613:Vaccines, Attenuated / Q000008:administration & dosage
D006510:Hepatitis B Antibodies; D007252:Influenza Vaccines; D010710:Phosphates; D014613:Vaccines, Attenuated; D008274:Magnesium
Réponse au vaccin grippal chez les urémiques: relation avec le magnésium érythrocytaire et intérêt d'une seconde injection.