title: [Successful treatment of a brain abscess with antibiotics and drainage puncture in an 11-year-old boy with a complex cyanotic heart defect].
abstract: A Blalock-Taussig-anastomosis was performed at the age of 2 years in a boy with transposition of the great arteries, ventricular septal defect, and pulmonary atresia. Nine years later he developed a transient aphasia. Cranial computed tomography (CT-scan) revealed a structure compatible with brain abscess. The boy was conscious and no neurological deficit was found. Initial therapy consisted of Ampicillin, Tobramycin, and Metronidazole, 12 days later an acute hemiplegia developed. 30 ml of pus were aspirated from the brain abscess, and the boy's condition dramatically improved. Streptococcus milleri was found bacteriologically and antibiotic therapy was continued over six weeks. Serial CT-scans during and after therapy demonstrated disappearance of the brain abscess. The presented case shows that after a shunt procedure in cyanotic heart disease right-to-left-shunting and therefore chronic oxygen desaturation and polycythemia are still present as facilitating factors for focal encephalomalacia, cerebritis, and brain abscess. In case of short duration of neurological symptoms and a size of abscess less than 4 cm in diameter antibiotic therapy without total excision may eliminate the infection.
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001922:Brain Abscess / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D003907:Dexamethasone / Q000627:therapeutic use; D004322:Drainage; D004359:Drug Therapy, Combination; D006330:Heart Defects, Congenital / Q000150:complications*; D006801:Humans; D008297:Male; D013290:Streptococcal Infections / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D003907:Dexamethasone
vernacular_title: Erfolgreiche Behandlung eines Hirnabszesses mit Antibiotika und einer Entlastungspunktion bei einem 11 Jahre alten Jungen mit einem komplexen zyanotischen Herzfehler.