Abnormalities of cilia and chronic sinusitis.
An ultrastructural study was performed on 34 biopsy samples of the sinusal mucosa in 28 patients who were investigated for chronic sinusitis. Twelve specimens with normoplastic sinusitis and eighteen with hyperplastic sinusitis were studied. Four normal specimens served as controls. The incidence of ultrastructural ciliary abnormalities was 2%. Morphological changes of dynein arms have not been observed in the present study. Compound cilia were found in approximately 2/3 of the studied cases. Microtubular abnormalities occurred in roughly 50%. The observed abnormalities, also seen in the control group, were independent on the sinusitis type and could not been correlated with mucociliary transport. Their significance is discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D001980:Bronchi / Q000473:pathology; D002648:Child; D002908:Chronic Disease; D002923:Cilia / Q000648:ultrastructure; D002925:Ciliary Motility Disorders / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D009297:Nasal Mucosa / Q000473:pathology; D012852:Sinusitis / Q000473:pathology*