Pharmacokinetic profile of indoprofen in elderly subjects.
Multiple dosing four times daily for 7 days of indoprofen 200 mg, a non-steroidal anti-inflammatory drug with a short half-life (t1/2), revealed drug accumulation in eight elderly subjects. This indicates a substantially longer t1/2 (11 h) than that reported in young persons (3 h). A reduction in dose compared to younger subjects is recommended in elderly patients with osteoarthritis.
D000368:Aged; D005260:Female; D006207:Half-Life; D006801:Humans; D007216:Indoprofen / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy; D010666:Phenylpropionates / Q000378:metabolism*
D010666:Phenylpropionates; D007216:Indoprofen