Extensive metabolizers of debrisoquine become poor metabolizers during quinidine treatment.
Seven male patients (age 55-75 years) were debrisoquine-tested immediately before and after one week of treatment with quinidine sulphate (200 mg X 3-4 day-1). Before quinidine all patients were classified as extensive metabolizers (metabolic ratio 0.1-3.6). During quinidine the formation of 4-OH-debrisoquine was practically abolished and the phenotype of the patients was altered to PM (metabolic ratio 15-51). This is probably due to an inhibition of debrisoquine hydroxylation by quinidine. Inhibition of 4-OH-debrisoquine formation was associated with a disproportionate increase in debrisoquine excretion.
D000368:Aged; D003647:Debrisoquin / Q000378:metabolism*; D003864:Depression, Chemical; D006801:Humans; D006900:Hydroxylation; D007546:Isoquinolines / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011802:Quinidine / Q000494:pharmacology*
D007546:Isoquinolines; D011802:Quinidine; D003647:Debrisoquin