title: Sex differences in the effects of haloperidol, morphine, and their combination on colonic temperature in rats.
abstract: Previously it was found that during the loss of postural support induced by combined administration of haloperidol and morphine, rats became markedly hypothermic. The present work was a more detailed study of this hypothermia. Morphine alone (20 mg/kg) produced a slight hyperthermia (1 degrees C) in female rats and no effect in males. Haloperidol alone (5 mg/kg) elicited a hypothermia of about 3 degrees C in females and no effect in males. The combination of both elicited a greater decrease of temperature (about 5 degrees C) in female rats and, unexpectedly, a decrease of 3 degrees C in males. According to these data, increased endorphinic activity with a concomitant decrease in dopamine in some unidentified regions of the central nervous system causes hypothermia.
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D003106:Colon / Q000187:drug effects; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D012727:Sex Characteristics; D013997:Time Factors
chemical_list: D009020:Morphine; D006220:Haloperidol