Differences in lymphocyte mitogenic stimulation pattern depending on anaesthesia and operative trauma: II. Combined neuroleptanaesthesia.
In this study, neuroleptanaesthesia reduced the reactivity of lymphocytes to phytohaemagglutin (PHA-P) and pokeweed mitogen (PWM) in patients in a manner similar to that seen with halothane/nitrous oxide and enflurane/nitrous oxide inhalational anaesthesia. These findings began 4 h post-operatively, lasted throughout the first post-operative day and were similar in both operative trauma groups (eye surgery/gynaecological surgery). However, unlike the situation with the inhalational agent, Concanavalin A (Con A)-induced proliferation did not alter. It was also noted that, on the third post-operative day in both trauma groups, PHA-P- and PWM-induced proliferation ratios were significantly higher than were the pre-operative values. These findings could be the result of a specific effect of neuroleptanaesthesia.
D000328:Adult; D003208:Concanavalin A / Q000494:pharmacology; D005128:Eye Diseases / Q000601:surgery*; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009458:Neuroleptanalgesia; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013997:Time Factors
D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A