title: Target regions enhance the outgrowth and survival of ganglion cells in embryonic retina transplanted to cerebral cortex in neonatal rats.
abstract: In embryonic mouse retina transplanted to occipital cortex of neonatal rats, ganglion cells do not project axons into the host cortex, although they may survive up to but not beyond 6 weeks post-transplantation. By contrast, if embryonic tectum or diencephalon is transplanted along with the retina, ganglion cells exhibit vigorous outgrowth to specific regions of the co-transplant and are able to survive for at least 14 weeks.
mesh_terms: D000367:Age Factors; D000818:Animals; D001369:Axons / Q000502:physiology; D002454:Cell Differentiation; D004027:Diencephalon / Q000502:physiology / Q000637:transplantation; D051379:Mice; D009473:Neuronal Plasticity; D009778:Occipital Lobe / Q000502:physiology* / Q000601:surgery; D051381:Rats; D012160:Retina / Q000196:embryology / Q000502:physiology* / Q000637:transplantation*; D012165:Retinal Ganglion Cells / Q000502:physiology*; D013477:Superior Colliculi / Q000502:physiology / Q000637:transplantation; D014183:Transplantation, Heterologous