title: Oxidation-reduction potential studies: a new method in pharmacology principles, materials, and methods.
abstract: Oxidation-reduction (redox) potential measurement is not used in pharmacology at the present time. However, it represents a physicochemical parameter that may be as important as the other currently used physicochemical parameters, such as pH and pKa. Redox potential variations include conformational modifications that may influence bioavailability of drugs. We report here an original and convenient equilibrium method to determine this potential in biological fluids, especially in blood.
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D010084:Oxidation-Reduction; D010600:Pharmacology; D011199:Potentiometry