Amplification of serotonin-induced contractions of isolated porcine coronary arteries after pretreatment with therapeutic doses of beta-methyldigoxin.
The present experiments demonstrate that after pretreatment of isolated porcine coronary arteries with therapeutic (2.5 X 10(-9) M) was well as with toxic (10(-6) M) doses of beta-methyldigoxin the serotonin-induced contractions were significantly amplified. Since serotonin released from destroyed thrombocytes may be one of the triggering factors eliciting coronary spasms, caution must be taken in the use of digitalis in coronary disease of spastic origin.
D000818:Animals; D002301:Cardiac Glycosides / Q000494:pharmacology*; D003331:Coronary Vessels / Q000187:drug effects; D004077:Digoxin / Q000031:analogs & derivatives*; D066298:In Vitro Techniques; D008520:Medigoxin / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology*; D013552:Swine
D002301:Cardiac Glycosides; D012701:Serotonin; D004077:Digoxin; D008520:Medigoxin