[In vitro and in vivo photochemical reactivity of methaqualone-1-oxide].
Methaqualone-1-oxide (1) exhibits photochemical reactivity. By irradiation of 1 with solar light the oxaziridin 3 is formed at first, which reacts in vitro (human proteins) and in vivo (rats) with macromolecules. As result of the photochemical in vitro and in vivo reactions of 1 the photoproduct 2-acetamidobenzoic acid-2'-methylanilide (6), involved in oxidation of protic compounds, was detected and after hydrolysis of proteins it appears that the short-lived 3 was adding to proteins.
D000818:Animals; D004048:Diethylamines; D006868:Hydrolysis; D008297:Male; D008702:Methaqualone / Q000031:analogs & derivatives* / Q000032:analysis; D010084:Oxidation-Reduction; D010777:Photochemistry; D051381:Rats; D011919:Rats, Inbred Strains
D004048:Diethylamines; C046511:methaqualone-1-oxide; D008702:Methaqualone
In-vitro- und in-vivo-Untersuchungen zur fotochemischen Reaktivität von Methaqualon-1-oxid.