Suppression of kindled seizures by cysteamine: dependence on injection-to-kindled seizure interval.
A single injection of cysteamine, 200 mg/kg i.p., administered 4 h before a kindling session induces long-term suppression of kindled seizures. Injection of cysteamine 2, 4 or 6 h after or 24 h before the kindling session is either less effective or ineffective. The present series of experiments shows that the injection-to-kindled seizure interval is critically important for the long-term inhibition. We propose that the anticonvulsant effect is caused by an interaction of the cysteamine and the kindled seizure.
D000679:Amygdala / Q000502:physiology; D000818:Animals; D000927:Anticonvulsants; D003543:Cysteamine / Q000494:pharmacology*; D006624:Hippocampus / Q000502:physiology; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000927:Anticonvulsants; D003543:Cysteamine