[Markers of hepatitis B virus infection in infants born of mothers who are HBs-antigen carriers with anti-HBe present and the problems of passive immunoprophylaxis].
In December, 1983 to December, 1985, blood sera of 14,603 pregnant women were tested for the detection of HBsAg carriers among them. A low level (1.1%) of HBsAg carrier state was demonstrated. HBeAg was detected in 5.2% of women-carriers of HBsAg, anti-HBe in 68.8%. The follow-up observations involved 59 babies born to the mothers HBsAg-carriers. The babies were divided into an experimental and a control group. The experimental group consisted of 22 babies who were given specific anti-HBs immunoglobulin, 37 babies of the control group did not receive this preparation. In the experimental group, 3 babies were found to be infected, all of them at the age of 9-12 months. In the control group the infection was detected in 9 babies, among them in 5 the markers of hepatitis B virus were detected at the age of 1-2 months. Based on these data, the efficacy of using anti-HBs immunoglobulin for prevention of neonatal hepatitis B is discussed.
D002353:Carrier State / Q000276:immunology*; D002908:Chronic Disease; D005260:Female; D006509:Hepatitis B / Q000276:immunology* / Q000517:prevention & control / Q000635:transmission; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis / Q000276:immunology*; D006801:Humans; D007116:Immunization, Passive; D007159:Immunologic Tests; D007223:Infant; D007231:Infant, Newborn; D049590:Postpartum Period; D011247:Pregnancy; D012306:Risk
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens
Markery HB-virusnoĭ infektsii u deteĭ, rodivshikhsia u matereĭ-nositeleĭ HBs-antigena s nalichiem anti-HBe, i voprosy passivnoĭ immunoprofilaktiki.