[Cortexolone as a modulator of diazepam activity].
The influence of ACTH (200 micrograms/kg), corticosterone (20 mg/kg) and cortexolone (20 mg/kg) on the anxiolytic activity of diazepam was studied. ACTH partly and corticosterone completely blocked the action of diazepam. Cortexolone injection 30 min before the administration of diazepam induced a 100% anxiolytic effect of diazepam in the range of doses from 0.1 to 0.3 mg/kg (ED50 of anxiolytic diazepam effect is 0.2 mg/kg). The role of stress hormones in the regulation of psychotropic drug activity is discussed.
D015065:17-Hydroxycorticosteroids / Q000494:pharmacology*; D000374:Aggression / Q000187:drug effects; D000818:Animals; D003220:Conflict, Psychological; D003345:Corticosterone / Q000494:pharmacology; D003350:Cortodoxone / Q000494:pharmacology*; D003366:Cosyntropin / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology
D015065:17-Hydroxycorticosteroids; D003366:Cosyntropin; D003975:Diazepam; D003345:Corticosterone; D003350:Cortodoxone
Korteksolon kak moduliator aktivnosti diazepama.