Ultraviolet excimer laser ablation: the effect of wavelength and repetition rate on in vivo guinea pig skin.
Multiple dermatologic conditions that are currently treated with traditional cold-knife surgery are amenable to laser therapy. The ideal surgical treatment would be precise and total removal of abnormal tissue with maximal sparing of remaining structures. The ultraviolet (UV) excimer laser is capable of such precise tissue removal due to the penetration depth of 193 nm and 248 nm irradiation of 1 micron per pulse. This type of ablative tissue removal requires a high repetition rate for efficient lesional destruction. Excimer laser radiation at 193 nm is capable of high repetition rates, which are necessary while 248 nm radiation causes increasing nonspecific thermal injury as the laser repetition rate is increased.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006168:Guinea Pigs; D053685:Laser Therapy; D012867:Skin / Q000473:pathology / Q000528:radiation effects*; D014467:Ultraviolet Therapy