title: Changes in catecholamine levels in discrete regions of rat brain during aging.
abstract: The effect of aging on the levels of dopamine (DA) in striatum and noradrenaline (NA) in cerebral cortex, cerebellum, hypothalamus, midbrain and pons-medulla from young adult and five groups of aging rats was evaluated. Determinations of the levels of these amines were conducted. Age-related changes which commenced at 12 months were observed in specific brain regions. The endogenous content of NA decreased significantly in hypothalamus, midbrain, and pons-medulla when compared with the same regions from young adult animals. These results show that central noradrenergic system is markedly vulnerable to the aging process in rats.
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001923:Brain Chemistry; D002531:Cerebellum / Q000032:analysis; D002540:Cerebral Cortex / Q000032:analysis; D003342:Corpus Striatum / Q000032:analysis; D004298:Dopamine / Q000032:analysis*; D007031:Hypothalamus / Q000032:analysis; D008297:Male; D008526:Medulla Oblongata / Q000032:analysis; D008636:Mesencephalon / Q000032:analysis; D009638:Norepinephrine / Q000032:analysis*; D011149:Pons / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004298:Dopamine; D009638:Norepinephrine