Cytotoxicity of Shiga toxin for primary cultures of human colonic and ileal epithelial cells.
Shiga toxin purified from Shigella dysenteriae 1 was cytotoxic to cultured epithelial cells from human colon and ileum. The cytotoxicity, which affected only about 50% of treated cells, was neutralized by rabbit antiserum monospecific for Shiga toxin and mediated by protein synthesis inhibition.
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D002478:Cells, Cultured; D003106:Colon / Q000187:drug effects* / Q000382:microbiology; D004848:Epithelium / Q000187:drug effects / Q000382:microbiology; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007082:Ileum / Q000187:drug effects* / Q000382:microbiology; D007106:Immune Sera / Q000276:immunology; D011817:Rabbits / Q000276:immunology; D022603:Shiga Toxins
D001427:Bacterial Toxins; D007106:Immune Sera; D022603:Shiga Toxins