title: Anaesthesia and intra-ocular pressure in young children. A study of three different techniques of anaesthesia.
abstract: This study compares the effects of three anaesthetic techniques on intra-ocular pressure (IOP) in infants and children: spontaneous ventilation using nitrous oxide with halothane (group 1) or isoflurane (group 2) and controlled ventilation with atracurium (group 3). The IOP remained constant in groups 1 and 2 until the administration of suxamethonium when it rose significantly; this rise was maintained during tracheal intubation. In group 3 IOP increased on administering atracurium and a further increase was seen during tracheal intubation. Diagnostic intra-ocular pressure measurements should be made during spontaneous breathing prior to tracheal intubation. The IOP was not directly affected by arterial blood pressure or by expired CO2 tension.
mesh_terms: D000769:Anesthesia, Inhalation / Q000379:methods*; D001279:Atracurium / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D007223:Infant; D007429:Intraocular Pressure / Q000187:drug effects; D007530:Isoflurane / Q000494:pharmacology; D009609:Nitrous Oxide; D012121:Respiration, Artificial
chemical_list: D001279:Atracurium; D007530:Isoflurane; D009609:Nitrous Oxide; D006221:Halothane