[Effect of immunomodulation following allogeneic blood transfusion on tumor neogenesis and growth--experimental studies in rats].
The influence of allogeneic blood transfusions (BT) on experimental tumor growth was investigated in three syngeneic, one allogeneic and one autochthonous tumor model in the rat. Con A induced T-cell response, relative distribution of lymphocyte subsets using flow cytometry and cytotoxic antibodies were determined. No differences in take rate, induction time, incidence and growth rate of tumors were observed in the different models. A significant decrease of cell-mediated immunity and a significant increase of peripheral Ia-positive cells could be observed. The relative distribution of T-cell subsets showed no differences between BT-groups and controls.
D000230:Adenocarcinoma / Q000139:chemically induced; D000276:Adjuvants, Immunologic; D000818:Animals; D001564:Benzo(a)pyrene; D001803:Blood Transfusion / Q000379:methods; D005038:Ethylnitrosourea; D005354:Fibrosarcoma / Q000139:chemically induced; D008769:Methylnitronitrosoguanidine; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D009463:Neuroma / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000139:chemically induced; D014181:Transplantation Immunology
D000276:Adjuvants, Immunologic; D008769:Methylnitronitrosoguanidine; D001564:Benzo(a)pyrene; D005038:Ethylnitrosourea
Einfluss der Immunmodulation nach allogenen Bluttransfusionen auf Neogenese und Wachstum von Tumoren--Experimentelle Studien in der Ratte.