Pharmacokinetics of diacetoxyscirpenol in cattle and swine: effects of halothane.
In swine and cattle given 0, 0.1, or 0.5 and 0, 0.5 mg of diacetoxyscirpenol (DAS)/kg of body weight, IV, respectively; DAS had a large volume of distribution and total body clearance. The shortness of the interval between halothane and DAS exposures significantly (P greater than 0.05) decreased DAS biotransformation. Urinary excretion of DAS as a parent compound was not an important route of elimination. In swine and cattle, DAS was transformed by sequential deacetylation to monoacetoxyscirpenol and scirpentriol.
D000768:Anesthesia, General / Q000662:veterinary; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000378:metabolism* / Q000633:toxicity; D001711:Biotransformation; D002417:Cattle / Q000378:metabolism*; D005260:Female; D006221:Halothane / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009183:Mycotoxins / Q000378:metabolism / Q000633:toxicity; D012717:Sesquiterpenes / Q000378:metabolism*; D013552:Swine / Q000378:metabolism*; D014255:Trichothecenes / Q000378:metabolism* / Q000633:toxicity
D000972:Antineoplastic Agents, Phytogenic; D009183:Mycotoxins; D012717:Sesquiterpenes; D014255:Trichothecenes; D006221:Halothane; C001809:diacetoxyscirpenol