[Reduced malignancy of hybrids of tumor cells fused with lymph node lymphocytes of syngeneic rats].
Seven cloned hybrid cell lines were obtained by fusion of OAV2a GFRT cells with lymphocytes of syngeneic rats. Three of the cell lines showed a reduced malignity when injected subcutaneously and were incapable of infiltrative growth when injected intraperitoneally. They were partially or totally devoid of colony forming activity in soft agar. Tumors which formed after injection of clone 2 cells revealed degenerative alterations and were infiltrated with lymphocytes. Separately floating rejected tumor fragments were vigorously attacked by macrophages.
D000818:Animals; D002459:Cell Fusion; D002471:Cell Transformation, Neoplastic / Q000276:immunology* / Q000473:pathology; D005354:Fibrosarcoma / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D007621:Karyotyping; D008198:Lymph Nodes / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology* / Q000648:ultrastructure; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains
Snizhenie zlokachestvennosti gibridov opukholevykh kletok s limfotsitami limfouzlov singennykh krys.