[Transport and metabolism of a membrane-active complexon in the mouse body].
Two-phase decrease in content of N-(3H-aminoacetyl)-I-aza-4,7,10,11-tetraoxacyclopentadecane hydrochloride (ATCH) and of its metabolites as well as absence of accumulation were observed in mice tissues. Kinetic parameters of 3H-products elimination estimated by means of sequental logarithmation enabled to suggest that ATCH and its free metabolites were intensively involved in biotransformation of molecules. 3H-glycine was found not to be a product of the ATCH metabolism. High and stable level (from 10 min up to 24 hrs) of water soluble and protein-bound derivatives of ATCH were found in mice liver tissue and blood plasma after intravenous administration of the macroheterocycle.
D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D004988:Ethers, Cyclic / Q000378:metabolism*; D005998:Glycine / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051379:Mice; D014018:Tissue Distribution
D004988:Ethers, Cyclic; C052218:N-(aminoacetyl)-1-aza-4,7,10-13-tetraoxacyclopentadecane; D005998:Glycine
Transport i metabolizm membranoaktivnogo kompleksona v organizme mysheĭ.