Lesions of the posterior septum or of the habenula decrease [3H]hemicholinium-3 binding (as measured by autoradiography) in the interpeduncular nucleus of the rat.
The effects of a bilateral electrolytic lesion of the posterior septum or of the habenula (lateral and medial parts) on [3H]hemicholinium-3 binding sites in the interpeduncular nucleus of the rat were studied through the use of quantitative autoradiography. Lesions of the habenular nuclei or of the posterior septum decreased [3H]hemicholinium-3 binding in the interpeduncular nucleus by 93 and 31%, respectively. These results add further support to the view that the habenula and posterior septum are the major sources of the cholinergic innervation of the interpeduncular nucleus in the rat.
D000818:Animals; D001345:Autoradiography; D001665:Binding Sites; D002799:Cholinergic Fibers / Q000033:anatomy & histology / Q000378:metabolism*; D004027:Diencephalon / Q000033:anatomy & histology / Q000502:physiology*; D006426:Hemicholinium 3 / Q000378:metabolism*; D008032:Limbic System / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012688:Septum Pellucidum / Q000033:anatomy & histology / Q000502:physiology*; D013681:Tegmentum Mesencephali / Q000033:anatomy & histology / Q000378:metabolism*; D013687:Telencephalon / Q000378:metabolism
D006426:Hemicholinium 3