Effects of perinatal exposure of albino rats to chloroquine.
The effects of perinatal exposure of Wistar-derived albino rats to chloroquine were studied. Chronic exposure to 10 mg/kg of chloroquine phosphate during intra-uterine and postnatal life resulted in a marked decrease in neonatal and postweaning body and organ weights. The fasting blood glucose level was significantly elevated at 8 weeks of age in animals exposed to chloroquine. The observed growth retardation suggested transplacental poisoning and poisoning through milk transfer. The elevation in blood sugar level could be a consequence of possible ultrastructural and biochemical alterations of pancreatic B cells.
D000818:Animals; D000831:Animals, Newborn / Q000033:anatomy & histology*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects; D002738:Chloroquine / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006128:Growth / Q000187:drug effects*; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D002738:Chloroquine