[Effect of lymphocytes on the differentiation of in vitro transformed L-line mouse fibroblasts].
Possible participation of immune system cells in the differentiation of non-lymphoid tissues has been examined. Lymphocytes were tested on transformed fibroblasts of L mouse strain. The presence of lymphocytes in L cell culture enhanced their differentiation, assessed by morphological, proliferative and biophysical criteria. The induction of L-cell differentiation took place during contact and short-distant interaction both with mouse and human lymphocytes. The phenomenon had a stable character, as it was revealed in L cells separated from lymphocytes during passaging. The results obtained indicate real and potential abilities of the immune system to affect differentiation of proliferating non-lymphoid tissues.
D000818:Animals; D002448:Cell Adhesion; D002450:Cell Communication; D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D007739:L Cells / Q000166:cytology* / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H
Vliianie limfotsitov na differentsirovku in vitro transformirovannykh myshinykh fibroblastov linii L.