An investigation of the angry back syndrome using Trafuril.
The angry back syndrome (ABS) was investigated using Trafuril cream and prostaglandin synthetase inhibitors. Trafuril produced an increase in the numbers and intensity of patch test reactions which was partly abrogated by aspirin and indomethacin. Irritant reactions were not affected. We suggest that Trafuril may increase the sensitivity of the patch testing system and that this may have useful clinical applications.
D001241:Aspirin / Q000494:pharmacology; D004890:Erythema / Q000139:chemically induced; D005189:False Positive Reactions; D005663:Furans / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D009539:Nicotinic Acids / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D010328:Patch Tests; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests
D005663:Furans; D009539:Nicotinic Acids; C005813:thurfyl nicotinate; D001241:Aspirin; D007213:Indomethacin