title: Study of the morphological, electrophysiological and behavioral effects of unilateral kainic acid injection into the cat's substantia nigra.
abstract: Morphological, electrophysiological and behavioral studies were carried out in cats after unilateral kainic acid injection in the substantia nigra. A forced contralateral head turning and compulsive circling was observed after surgery. Fifteen days after, when asymmetry disappeared, apomorphine induced an ipsilateral head and body turning, that was blocked by haloperidol. The percentage of turning, after electrical stimulation in the superior colliculus or pulvinar-lateralis posterior complex, was affected by substantia nigra lesion. This work demonstrates that the nigro-pulvinar-lateral posterior and the nigrotectal projection modulate the capability of electrical stimulation of the target structures to elicit turning, and after unilateral substantia nigra lesion, two opposite directions of asymmetry appear, which are time-dependent and modulated by different neurotransmitters.
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001931:Brain Mapping; D002415:Cats; D004298:Dopamine / Q000502:physiology; D006220:Haloperidol / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D009434:Neural Pathways / Q000187:drug effects; D013378:Substantia Nigra / Q000187:drug effects*; D013477:Superior Colliculi / Q000187:drug effects; D013787:Thalamic Nuclei / Q000187:drug effects
chemical_list: D006220:Haloperidol; D001058:Apomorphine; D007608:Kainic Acid; D004298:Dopamine