Aspirin, indomethacin, and tartrazine increase carotid-sinus-nerve activity and arterial blood pressure in guinea pigs.
Acetylsalicylic acid (ASA; 0.1-10 mg/kg), indomethacin (IND; 0.1-1.0 mg/kg), and tartrazine (TZ; 0.1-2.0 mg/kg), given intravenously induced dose-dependent increases in carotid-sinus nerve (CSN) activity, accompanied by increases in mean arterial blood pressure (MABP), but only the IND-induced MABP increases were dose-dependent. The MABP and CSN activity responses to all three drugs were not correlated, suggesting a direct action on CSN afferents that is unrelated to the pressor effects of the drugs. Sodium cromoglycate (10 mg/kg) selectively reduced the increases in CSN response to ASA and IND. Phentolamine (0.2 mg/kg) inhibited the increased CSN activity induced by ASA, IND, and TZ. These findings indicate that ASA, IND, and TZ act directly on carotid baroreceptors to increase their activity.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001391:Azo Compounds / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002346:Carotid Sinus / Q000294:innervation*; D005260:Female; D006168:Guinea Pigs; D007213:Indomethacin / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects; D010656:Phenylephrine / Q000494:pharmacology; D013268:Stimulation, Chemical; D013645:Tartrazine / Q000494:pharmacology*
D001391:Azo Compounds; D010656:Phenylephrine; D013645:Tartrazine; D001241:Aspirin; D007213:Indomethacin