Carbamazepine-induced acute cholangitis.
We report the case of a patient with carbamazepine-induced cholestasis in whom histologic examination showed acute cholangitis. This type of lesion broadens the spectrum of carbamazepine-induced liver injury which also includes granuloma and hepatocellular necrosis. Its association with marked hypereosinophilia suggests that carbamazepine may cause acute cholangitis through an immunoallergic mechanism.
D000368:Aged; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D001706:Biopsy; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D002761:Cholangitis / Q000139:chemically induced* / Q000473:pathology; D004802:Eosinophilia / Q000139:chemically induced; D005156:Facial Neuralgia / Q000188:drug therapy; D005260:Female; D006801:Humans
D002220:Carbamazepine