Guinea pig pancreatic polypeptide: structure and pancreatic content.
Guinea pig (GP) pancreatic polypeptide (PP) has been purified from an acid-alcohol extract of 6 GP pancreata by a series of 3 HPLC steps. The sequence for GP PP as compared with that of beef and human is shown: (Sequence: see text). In a single GP pancreas weighing 2.4 g the total PP content was 1.0 nmol and the total glucagon content 61 nmol; in a single dog pancreas weighing 35 g the total PP was 385 nmol and the total glucagon 81 nmol. The relatively low content of PP in GP pancreas is consistent with the fact that the GP lacks a ventral pancreas, the region in which PP is found in highest concentration. The high glucagon content of GP pancreas is consistent with that reported in earlier studies.
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D005934:Glucagon / Q000032:analysis; D006168:Guinea Pigs; D010179:Pancreas / Q000032:analysis*; D010191:Pancreatic Polypeptide / Q000302:isolation & purification*; D011863:Radioimmunoassay
D010191:Pancreatic Polypeptide; D005934:Glucagon