title: The cholecystohepatic circulation of trichloroethylene and its metabolites in dogs.
abstract: In order to examine the cholecystohepatic circulation of trichloroethylene (TRI) and its metabolites, we injected the gallbladder with TRI and its metabolites, i.e. chloral hydrate (CH), free-trichloroethanol (F-TCE), trichloroacetic acid (TCA) and conjugated-trichloroethanol (Conj-TCE), using anesthetized dogs. The absorption rates of water from the gallbladder were 25-30% 2 h after administration for all substances. The absorption rates of substances were 65-70% in the CH, F-TCE and TRI groups, and 40-50% in the Conj-TCE and TCA groups 2 h after the administration. Conj-TCE in the blood absorbed from the gallbladder has a tendency to be directly transported to the venous system rather than to be taken into hepatocytes in the liver. All of the administered substances, in particular, F-TCE might be metabolized to other substances in the gallbladder.
mesh_terms: D000042:Absorption; D000818:Animals; D001646:Bile / Q000378:metabolism; D002697:Chloral Hydrate / Q000378:metabolism; D004285:Dogs; D005023:Ethylene Chlorohydrin / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D005704:Gallbladder / Q000378:metabolism*; D008658:Inactivation, Metabolic; D008099:Liver / Q000378:metabolism*; D008297:Male; D014238:Trichloroacetic Acid / Q000378:metabolism; D014241:Trichloroethylene / Q000378:metabolism*
chemical_list: C044588:1,1,2-trichloroethanol; D014241:Trichloroethylene; D002697:Chloral Hydrate; D014238:Trichloroacetic Acid; D005023:Ethylene Chlorohydrin