[Genetic analysis of inheritance of Na+, K+-cotransport rate, calcium level in erythrocytes and blood pressure in F2 hybrids of spontaneously hypertensive and normotensive rats].
Positive correlation between Na+, K+-cotransport speed values in platelets and arterial pressure (AP) medium values was disclosed in F2 murine hybrids with spontaneous hypertension (SHT) and in WKY controls as was the correlation between Ca erythrocytic levels and the value of delta AP-AP1-AP2, with AP1--systolic AP measured in alert animals, AP2--medium AP measured directly in anesthetized rats. The data obtained during the aforementioned experimental series together with those obtained in the premorbid stage provided for a conclusion that all the signs considered were inherited in chain with a positive deposit in AP and played an important role in the pathogenesis of primary arterial hypertension.
D000818:Animals; D001692:Biological Transport; D001794:Blood Pressure; D002118:Calcium / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006824:Hybridization, Genetic; D006973:Hypertension / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012964:Sodium / Q000378:metabolism*
D012964:Sodium; D011188:Potassium; D002118:Calcium
Geneticheskiĭ analiz nasledovaniia velichin skorosti Na+, K+- kotransporta, soderzhaniia kal'tsiia v éritrotsitakh i arterial'nogo davleniia u gibridov F2 spontanno gipertenzivnykh i normotenzivnykh krys.