[Comparative characteristics of the functioning of brain structures exposed to morphine and D-phenylalanine].
In experiments on rats it was shown that morphine and D-phenylalanine in doses of 5 and 100 mg/kg, respectively, produce a similar by the degree increase of pain reaction thresholds at stimulation of paws through the electrified floor of the chamber. Experiments on rabbits demonstrated that the main factor in morphine action is a decrease of excitability and blood filling of the reticular formation of the midbrain and the central gray matter and an increase of excitability of the dorsal hippocamp without significant changes in the frontal cortex excitability. D-phenylalanine also caused a decrease of excitability of the reticular formation but in contrast to morphine failed to change excitability of the dorsal hippocamp and enhanced excitability of the central gray matter.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D004558:Electric Stimulation; D004569:Electroencephalography; D005260:Female; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology; D010649:Phenylalanine / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects; D013997:Time Factors
D010649:Phenylalanine; D009020:Morphine
Sravnitel'naia kharakteristika funktsionirovaniia struktur mozga pri deĭstvii morfina i D-fenilalanina.