[Lethal action of accelerated heavy ions on mammalian cells as affected by inhibitors of DNA synthesis. A theoretical analysis].
Günter-Schulz's model and the authors' own model were used to study the dependence of radiosensitivity (D0(-1)) of Chinese hamster cells on linear energy transfer (LET) upon irradiation in standard conditions and in the presence of DNA synthesis inhibitors, arabinosylcytosine and hydroxyurea. A better agreement of the experimental and theoretical results was obtained using Kozubek-Krasavin's model than the model of Günter and Schulz.
D000818:Animals; D006224:Cricetinae; D003412:Cricetulus; D003561:Cytarabine / Q000494:pharmacology; D004247:DNA / Q000037:antagonists & inhibitors* / Q000528:radiation effects; D004601:Elementary Particles; D004735:Energy Transfer; D005720:Gamma Rays; D006918:Hydroxyurea / Q000494:pharmacology; D008433:Mathematics; D008954:Models, Biological; D010315:Particle Accelerators; D011836:Radiation Tolerance
D003561:Cytarabine; D004247:DNA; D006918:Hydroxyurea
Letal'noe deĭstvie uskorennykh tiazhelykh ionov na kletki mlekopitaiushchikh v usloviiakh vliianiia ingibitorov sinteza DNK. Teoreticheskiĭ analiz.