Filipin-sterol complexes at Schmidt-Lanterman incisures.
Employing the freeze-fracture technique, the distribution of filipin-sterol complexes was determined for membranes of peripheral nerve myelin. A heterogeneous distribution of complexes was observed with the greatest abundance on membranes associated with the cytoplasmic channels of Schmidt-Lanterman and longitudinal incisures. In addition there was an irregular network of well-labelled membrane bands in compact myelin. The results are related to a possible role for these channels and bands in the biochemical turnover of cholesterol in myelin.
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D005372:Filipin / Q000378:metabolism*; D005614:Freeze Fracturing; D008297:Male; D009186:Myelin Sheath / Q000378:metabolism* / Q000648:ultrastructure; D011090:Polyenes / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013261:Sterols / Q000378:metabolism*
D011090:Polyenes; D013261:Sterols; D005372:Filipin; D002784:Cholesterol