Impairment of colour vision associated with amiodarone keratopathy.
Objective changes in colour vision have not been demonstrated previously in patients on long-term amiodarone therapy, although the occurrence of blurring of vision and seeing coloured haloes around lights has been widely reported. In a masked study, colour vision was assessed in 15 patients who had been treated with amiodarone for 16-72 months. Subjects with extensive corneal microdeposits (Miller stage 3) had worse colour vision than subjects with mild or moderate corneal changes (Miller stages 1 and 2) (P = 0.02), and higher serum concentrations of the metabolite desethlyamiodarone (P = 0.008). The only subject with marked asymmetry of corneal changes had a long-standing unilateral ptosis, suggesting that exposure to light might influence the development of corneal changes.
D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D003118:Color Perception / Q000187:drug effects*; D003315:Cornea / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000638:Amiodarone