[Effect of rifampicin, lincomycin and staphylococcal vaccine on the beta-lysin activity of the blood serum of animals infected with Staphylococcus].
Changes in activity of beta-lysins in blood serum were studied in the time course on albino mice infected with staphylococci and treated with rifampicin, lincomycin and inactivated staphylococcal vaccine administered in combination or alone. It was shown that staphylococcal infection lowered activity of the serum beta-lysins in the animals and therapeutic use of inactivated staphylococcal vaccine stimulated beta-lysin activity. Therapeutic use of rifampicin or lincomycin under the same conditions lowered activity of beta-lysins. The inhibitory effect of rifampicin was less pronounced. Combined use of the antibiotics and the vaccine promoted an increase in activity of beta-lysins as compared to the use of the antibiotics alone.
D000818:Animals; D023181:Antimicrobial Cationic Peptides; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D001798:Blood Proteins; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D008034:Lincomycin / Q000627:therapeutic use*; D051379:Mice; D011506:Proteins; D012293:Rifampin / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000097:blood / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000276:immunology*; D013997:Time Factors
D023181:Antimicrobial Cationic Peptides; D001428:Bacterial Vaccines; D001798:Blood Proteins; D011506:Proteins; C011679:beta lysin, human; C475592:beta lysin, mouse; D008034:Lincomycin; D012293:Rifampin
Vliianie rifampitsina, linkomitsina i stafilokokkovoĭ vaktsiny na aktivnost' beta-lizinov v syvorotke krovi zhivotnykh, infitsirovannykh stafilokokkom.