Tobacco-specific N-nitrosamines in dry snuff.
Case-control studies have shown that the oral use of dry snuff has an aetiological association with cancer of the oral cavity. This communication reports high concentrations of the powerful carcinogen N'-nitrosonornicotine (9.37-55.3 micrograms/g), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (1.98-14.4 micrograms/g) and of N'-nitrosoanatabine (18.8-40.2 micrograms/g) and N'-nitrosoanabasine (0.66-1.17 microgram/g) in three popular brands of dry snuff available in the USA.
D000470:Alkaloids / Q000032:analysis; D009566:Nitrates / Q000032:analysis; D009602:Nitrosamines / Q000032:analysis*; D010947:Plants, Toxic; D014026:Nicotiana / Q000032:analysis*; D014030:Tobacco, Smokeless / Q000032:analysis*; D014867:Water
D000470:Alkaloids; D009566:Nitrates; D009602:Nitrosamines; D014867:Water