Antiasthmatic effects of onions. Inhibition of platelet-activating factor-induced bronchial obstruction by onion oils.
Lyophilized onion extract and ether extracts of onions were separated by chromatographic methods into several subfractions and tested for their effects on asthmatic reactions of guinea pigs to allergen, histamine, acetylcholine and platelet-activating factor (PAF) inhalation as well as on thromboxane biosynthesis of human platelets and lung fibroblasts. Onion oils are counteracting the bronchial obstruction due to PAF inhalation.
D000490:Allium / Q000032:analysis*; D000818:Animals; D001249:Asthma / Q000503:physiopathology / Q000517:prevention & control*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D001985:Bronchial Provocation Tests; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D010938:Plant Oils / Q000494:pharmacology / Q000627:therapeutic use*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D013929:Thromboxane B2 / Q000096:biosynthesis
D010938:Plant Oils; D010972:Platelet Activating Factor; D013929:Thromboxane B2