title: Qualitative study of chromosomal lesions induced by neutrons and neon ions in human lymphocytes at G0 phase.
abstract: Chromosomal lesions, mitotic index and cell cycle progression delay induced by neutron (protons 34 MeV on beryllium) and neon (250 MeV/i) particles are studied in human lymphocytes. The cell cycle progression is slightly decreased at a dose of 1 Gy. Mitotic indexes are significantly decreased after irradiation by the different particles, except neon in 52-h cultures. By comparison to chromosome damages caused by gamma-rays, previously published, it is found that the lesions observed here are frequently more complex: the number of breaks is higher per abnormal mitosis and higher per rearrangement on the average. This complexity is higher for neon ions than for neutron beams.
mesh_terms: D002453:Cell Cycle / Q000187:drug effects*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D066298:In Vitro Techniques; D007399:Interphase / Q000528:radiation effects; D007477:Ions; D008940:Mitotic Index / Q000187:drug effects; D009356:Neon; D009502:Neutrons
chemical_list: D007477:Ions; D009356:Neon