Pirenperone effects on temperature preference and body temperature in maturing mice.
Thermoregulatory effects of the selective 5-HT2 antagonist pirenperone were studied 1 hr after IP injection in mice aged 1, 3, 5, 7 and 10 days postpartum. Compared with vehicle injected littermates, a dose of 0.16 mg/kg decreased temperature preference (T pref) on a thermal gradient at all ages. No significant effects were observed on body temperature (Tb) at any of the ages. An increased dose (0.48 mg/kg) caused no greater effect on T pref and no significant effect on Tb. These results indicate that Tb and T pref are separable on the basis of receptor pharmacology, and are discussed in relation to drug effects on 5-HT2 receptors.
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001831:Body Temperature / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D010880:Piperidines / Q000494:pharmacology*; D013697:Thermosensing
D010880:Piperidines; C034177:pirenperone