Increase in chloride ion permeability across the nerve cell membrane after the endogenous antigen S-100 incorporation.
36Cl fluxes through microdissected Deiters' neuronal membranes have been studied in a microchamber device simulating the extra- and intracellular compartments. GABA stimulates Cl- permeability through the membranes by 24%. Also, S-100/Ca2+ incorporation into the Deiters' membrane increases 36Cl- permeation to a similar extent. The two effects do not appear to be additive. This circumstance is interpreted as indicating that S-100/Ca2+ exerts its effects via postsynaptic GABAA receptor complexes.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D011817:Rabbits; D009418:S100 Proteins / Q000378:metabolism* / Q000494:pharmacology; D013997:Time Factors; D003689:Vestibular Nucleus, Lateral / Q000166:cytology / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D002712:Chlorides; D009418:S100 Proteins; D005680:gamma-Aminobutyric Acid