Phenylbutazone-induced myelodysplastic syndrome with Philadelphia translocation.
We present a case of a 69-year-old white male with a 3-year history of a myelodysplastic syndrome probably induced by phenylbutazone, and which developed into an overt leukemic phase. Chromosome analysis in the leukemic phase revealed the bone marrow cells to contain a Philadelphia translocation [46,XY,t(9;22)(q34;q11)]. We discuss the possible association between a prior history of exposure to hemotoxins and myelodysplastic syndromes, and the rarity of a Ph translocation in drug-induced hematologic malignancy.
D000368:Aged; D006801:Humans; D007621:Karyotyping; D008297:Male; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000235:genetics*; D010653:Phenylbutazone / Q000009:adverse effects*; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic
D010653:Phenylbutazone