[Effect of reduced fat content of the diet of the rat and a single fat load on the lipopexic function of the lungs and the development of silicosis].
A diet with low fat content did not influence the lipid level in the lungs and fibrinogenesis values in the development of silicosis in rats, due to the intensification of the lung lipopexic function, that was revealed in the prefibrosis period, using single fat load. A direct correlation of the lung lipopexic function degree in the prefibrosis period with the degree of pneumophibrosis developing afterwards was noted. The optimum time for the study of the rat lung lipopexic function was specified (1.5 h) after single fat load. It is recommended that the lung lipopexic function, as an indirect sign of the degree of the development of proliferative-cellular reactions in the lungs, be investigated in subjects engaged in the work associated with the risk of pneumoconiosis.
D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005355:Fibrosis; D006909:Hydroxyproline / Q000032:analysis; D008055:Lipids / Q000032:analysis*; D008099:Liver / Q000032:analysis; D008168:Lung / Q000032:analysis*; D008297:Male; D051381:Rats; D012829:Silicosis / Q000378:metabolism / Q000517:prevention & control*
D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D006909:Hydroxyproline
Vliianie ponizhennogo soderzhaniia zhira v ratsione krys i odnokratnoĭ zhirovoĭ nagruzki na lipopeksicheskuiu funktsiiu legkikh i razvitie silikoza.