Immunohistochemical analysis of the distribution of cathepsin D throughout human nervous system with reference to developmental aspects.
The aspartic endopeptidase cathepsin D was demonstrated in post mortem human brain by means of the peroxidase-antiperoxidase technique. The enzyme protein was found to be present in multiple neurons as well as in some glial cells. In embryonic nervous tissue cathepsin D was detected as early as at the 12th gestational week. During neuroontogenesis there was a continuous increase in cathepsin D immunoreactivity.
D000368:Aged; D000375:Aging / Q000502:physiology; D002402:Cathepsin D / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism; D005865:Gestational Age; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D008875:Middle Aged; D009420:Nervous System / Q000201:enzymology* / Q000254:growth & development; D011247:Pregnancy
D002402:Cathepsin D