Inactivation of synchronized mammalian cells with low-energy X rays--results and significance.
Results for inactivation of hydroxyurea-synchronized V-79 cells by ultrasoft aluminum characteristic X rays of energy 1.5 keV are presented. Limiting RBEs at low doses, relative to 137Cs gamma rays, of 1.8 and 6.4 are, respectively, found for cells at the G1/S and late S stages of the cell cycle. The late-S data are analyzed in the light of previous experiments carried out under similar conditions, also designed to probe the effects of energy deposition in nanometer-sized sites, in which cells were irradiated with correlated pairs of ions. Within the framework of the theory of dual radiation action, the results for ultrasoft X rays and gamma rays can be deduced solely from track simulations and the results of the high-LET molecular ion experiment.
D000818:Animals; D002453:Cell Cycle / Q000528:radiation effects; D002455:Cell Division; D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured / Q000528:radiation effects*; D012062:Relative Biological Effectiveness; D014965:X-Rays