Ganglioside treatments reduce locomotor hyperactivity after bilateral lesions of the entorhinal cortex.
The present study evaluated the effects of exogenous gangliosides (membrane glycolipids) on open-field locomotor activity after bilateral lesions of the entorhinal cortex. Saline-treated rats showed a dramatic increase in activity followed by a time-dependent recovery (i.e. return toward control levels). Ganglioside-treated (50 mg/kg total gangliosides; i.m.) rats exhibited a similar pattern of changes in activity, except that their level of hyperactivity at 2-6 days postlesion was reduced. Thus, exogenous gangliosides lessened the severity of the lesion-induced hyperactivity, but did not enhance the total net recovery.
D000818:Animals; D001925:Brain Damage, Chronic / Q000473:pathology; D005732:Gangliosides / Q000627:therapeutic use*; D006948:Hyperkinesis / Q000188:drug therapy* / Q000473:pathology; D008032:Limbic System / Q000473:pathology; D008297:Male; D009473:Neuronal Plasticity; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D005732:Gangliosides