Comparison of stimulants and hallucinogens on shuttle avoidance in rats.
Rats were trained to a high level of performance of a conditioned avoidance response in a shuttlebox to test effects of several classical stimulants in comparison to a variety of hallucinogens. A previously-reported biphasic pattern of effects of mescaline on shuttle avoidance was replicated and extended to 12 other hallucinogens of both phenylethylamine and indolealkylamine classes. Response patterns of hallucinogens could be differentiated from 3 stimulants and from a methoxyamphetamine compound that lacks hallucinogenic activity.
D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002491:Central Nervous System Agents / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects*; D006213:Hallucinogens / Q000494:pharmacology*; D008297:Male; D008635:Mescaline / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical; D014363:Tryptamines / Q000494:pharmacology
D000662:Amphetamines; D002491:Central Nervous System Agents; D006213:Hallucinogens; D011619:Psychotropic Drugs; D014363:Tryptamines; D008635:Mescaline