Toxicity of n-hexane and 2,5-hexanediol to the haemopoietic system: a preliminary report.
The effect of n-hexane and its metabolite, 2,5-hexanediol, on the haemopoietic system has been investigated in the rat. 59Fe uptake was decreased in the bone marrow of n-hexane-treated animals. Spleen and bone marrow were the target sites for the metabolite 2,5-hexanediol, whereas n-hexane as such does not affect these organs.
D000818:Animals; D006018:Glycols / Q000633:toxicity*; D006413:Hematopoietic System / Q000187:drug effects*; D006586:Hexanes / Q000633:toxicity*; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism; D007504:Iron Radioisotopes; D008297:Male; D000623:Porphobilinogen Synthase / Q000378:metabolism; D051381:Rats
D006018:Glycols; D006586:Hexanes; D007504:Iron Radioisotopes; C007938:2,5-hexanediol; C026385:n-hexane; D007501:Iron; D000623:Porphobilinogen Synthase