The effect of bilateral kainic acid-induced lateral habenula lesions on dopamine-mediated behaviors.
Bilateral kainic acid-induced lateral habenula lesions produced dose specific alterations in dopamine mediated behaviors in the rat. Intermediate doses of apomorphine and amphetamine produced potentiated stereotypic responsiveness while higher doses produced a behavioral response similar to that observed in sham-operated and virgin controls. Autoreceptor specific doses of apomorphine and its associated behavioral hypoactivity was unaffected by lesions. Animals with lesions did not exhibit the response potentiation normally induced by chronic haloperidol treatment.
D000818:Animals; D001931:Brain Mapping; D004027:Diencephalon / Q000187:drug effects* / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects* / Q000502:physiology
D006220:Haloperidol; D007608:Kainic Acid; D004298:Dopamine