[Effect of an analog of vasopressin on the fixation of temporary connections in the intact rat and after destruction of the locus coeruleus].
Subcutaneous injection to intact rats and rats with destroyed locus coeruleus of 10 mcg of triglycide-glycinamide-lysinevasopressin (TGDGA-LVP) immediately after elaboration of labyrinth defensive conditioned reflex improves consolidation of temporary connections and raises its resistance to extinction. Improved consolidation of temporary connection is retained in animals with destroyed locus coeruleus for a shorter time than in intact animals. At the same time according to some characteristics, TGDGA-LVP has a more expressed influence of positive character on animals with destroyed locus coeruleus than on intact rats.
D000320:Adrenergic Fibers / Q000187:drug effects; D000818:Animals; D001931:Brain Mapping; D003214:Conditioning, Classical / Q000187:drug effects*; D004597:Electroshock; D005108:Extinction, Psychological / Q000187:drug effects; D008027:Light; D008125:Locus Coeruleus / Q000187:drug effects*; D008236:Lypressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D009434:Neural Pathways / Q000187:drug effects; D051381:Rats; D013687:Telencephalon / Q000187:drug effects*
C003645:vasopressin, N-(N-Gly-Gly)-8-Lys-; D008236:Lypressin
Deĭstvie analoga vazopressina na fiksatsiiu vremennykh sviazeĭ u intaktnykh krys i posle razrusheniia golubogo piatna.