[Functional status of the myocardium of ischemic heart disease patients during long-term treatment with beta blockers].
Propranolol treatment for 6, 12 and 24 months was associated with a pronounced antianginal effect, both subjective and objective, in coronary patients, while the side effects rate was relatively small (3.3-7.3%). As the duration of treatment increases, the negative inotropic effect becomes less marked. Long-term propranolol treatment of coronary patients does not provoke any clinical signs of circulatory insufficiency. The treatment has the best effect in those coronary patients whose "double product" increases by more than 1.0 per 1 W of a standard 50 W load. The drug maximum antianginal effect is retained when this index drops below 1.0 in the course of two-week and six-month treatment.
D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D005080:Exercise Test; D005500:Follow-Up Studies; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology / Q000627:therapeutic use*; D013997:Time Factors
D011433:Propranolol
Funktsional'noe sostoianie miokarda u bol'nykh ishemicheskoĭ bolezn'iu serdtsa pri dlitel'nom lechenii beta-adrenoblokatorami.