title: Lack of synchrony between feeding activity and pulsatile growth hormone secretion in rats.
abstract: Plasma growth hormone (GH) was determined in blood sampled at 15 minute intervals in undisturbed chronically cannulated adult male rats while continuously monitoring feeding activity. Ten animals were studied; five were optic nerve sectioned from 24 days of age and five were intact. The sampling time was from 15:00 hours to 21:00 hours, which included 5 hours of light and the first hour of dark. Both GH secretion and feeding activity exhibited a pulsatile pattern. There was no consistent coordination of bursts of feeding activity and GH secretion. We conclude that feeding activity and GH secretion may be controlled by central timing mechanisms; however, it appears that these mechanisms are separate and are not synchronized.
mesh_terms: D000818:Animals; D004435:Eating; D013006:Growth Hormone / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D013006:Growth Hormone