title: [Hematoencephalic barrier function during irradiation under hypo- and hyperoxia].
abstract: The hematoencephalic barrier status was shown to change depending upon radiation dose and time after exposure. Synergism, additivity, and antagonism were observed after the combined effect of radiation and a changed gas medium. On the whole, hypoxic hypoxia, as opposed to air and oxygen, had a slight radioprotective effect, but after 5 h, no variations were virtually found in the groups animals exposed to superlethal radiation doses in different gas media.
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000528:radiation effects*; D001921:Brain / Q000187:drug effects / Q000528:radiation effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D010100:Oxygen / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D010100:Oxygen
vernacular_title: Sostoianie gematoéntsefalicheskogo bar'era pri obluchenii v usloviiakh gipo- i giperoksii.