The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro.
Clostridium difficile toxins A and B inhibited protein synthesis in McCoy tissue-culture cells but not in intestinal cells in vitro or in vivo. Toxins A and B had no effect on membrane permeability of either intestinal cells or McCoy cells.
D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000633:toxicity*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002478:Cells, Cultured; D003013:Clostridium / Q000472:pathogenicity*; D004768:Enterotoxins / Q000633:toxicity*; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D014176:Protein Biosynthesis; D011817:Rabbits
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004768:Enterotoxins; C041348:tcdA protein, Clostridium difficile; C031815:toxB protein, Clostridium difficile; D000469:Alkaline Phosphatase