[Direct approximation of plasma concentration time curves of 3-diethylstilbestrol monoglucuronide following oral and intravenous administration of fosfestrol].
Drugs undergoing presystemic elimination, enterohepatic recycling and multiple biotransformation show atypical plasma level curves with considerable deviations. The data are approximated by modified exponential functions, whose "intrinsic" properties anticipate the overall behaviour of the experimental data, even in complicated cases. The initial parameter estimates can be calculated directly from the experimental data.
D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000097:blood*; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood*; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics
D000970:Antineoplastic Agents; D004054:Diethylstilbestrol; C004955:fosfestrol; C029701:diethylstilbestrol monoglucuronide
Direkte Approximation von Plasma-Konzentrations-Zeit-Kurven des E-Diethylstilbestrol-Monoglucuronids nach oraler und i.v. Gabe von Fosfestrol.