title: Non-ocular cancer in hereditary retinoblastoma survivors and relatives.
abstract: An epidemiological survey has been carried out to establish the incidence of second malignant neoplasms in hereditary retinoblastoma survivors in The Netherlands and the relative risk of cancer in non-affected relatives. The cumulative incidence of second neoplasms was 19% at the age of 35 years. Fathers, unaffected by retinoblastoma, were at risk for pancreatic cancer, the relative risk being 8.3.
mesh_terms: D005134:Eye Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D012175:Retinoblastoma / Q000235:genetics*