[Dynamic light-evoked pupillometry for the differentiation of psychotropic substances].
In a double-blind placebo-controlled study 100 mg zotepine (neuroleptic) were administered to 15 young healthy volunteers; another 15 volunteers received 200 mg moclobemide (Ro 11-1163) (MAO-inhibitor). At the certain days of investigation the light-evoked pupillary reactions were recorded prior to and 2, 4, 6, and 8 h after medication. Using the dynamic pupillometric method it was possible to differentiate between zotepine and moclobemide in view of autonomous activation.
D000328:Adult; D001549:Benzamides / Q000494:pharmacology; D004311:Double-Blind Method; D006801:Humans; D008027:Light; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects*
D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D011619:Psychotropic Drugs; D020912:Moclobemide
Lichtevozierte dynamische Pupillometrie zur Differenzierung psychotroper Substanzen.