title: [Intravenous analgesia with ketamine for emergency patients].
abstract: Twenty traumatized patients suffering from fractures and soft tissue injury were given either 0.25 mg/kg or 0.5 mg/kg ketamine intravenously for analgesia. Within 5 min effective analgesia was present in both groups and lasted for 10-15 min. The higher dose of ketamine led to an impairment in the level of consciousness. These findings were in agreement with plasma levels of ketamine: in the 0.25 mg/kg group the plasma levels (median) were 167 ng/ml after 5 min, 92 ng/ml after 10 min, 82,5 ng/ml after 15 min, and 46 ng/ml after 30 min (n = 4). In the 0.5 mg/kg group the plasma levels (median) were 238 ng/ml after 5 min, 189 ng/ml after 10 min, 135 ng/ml after 15 min, and 118 ng/ml after 30 min. Considering the influence on consciousness, we recommend the administration of 0.25 mg/kg ketamine intravenously for analgesia in traumatized patients without head injury. It may be necessary to repeat the same dose if pain re appears.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004630:Emergencies; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007649:Ketamine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D014947:Wounds and Injuries / Q000150:complications*
chemical_list: D007649:Ketamine
vernacular_title: Intravenöse Analgesie mit Ketamin bei Notfallpatienten.