Chlordiazepoxide and stress tolerance in rats.
Intraperitoneal injections of chlordiazepoxide in rats attenuated the severity of stomach ulcers induced by a single restraint session. However, when the drug was withheld during the last session of a series of repeated restraint treatments, stomach erosions developed in the animals. Vehicle-controls, on the other hand, had adapted to the chronic stress, as indexed by a decline in gastric pathology. The results were discussed in reference to stress adaptation and drug withdrawal effects.
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000209:etiology / Q000503:physiopathology*; D013312:Stress, Physiological / Q000503:physiopathology*
D002707:Chlordiazepoxide