Increased sister chromatid exchange frequency at Xq27 site in affected fragile X males.
Sister chromatid exchange (SCE) was evaluated in peripheral blood lymphocytes cultured from normal subjects, fragile X carrier females, and fragile X affected males and in general did not differ among all subjects whether cells were grown in thymidine-deficient or complete medium. However, at the Xq27 site, SCE was significantly increased for fragile X affected males, particularly in cells grown in thymidine-deficient medium.
D002478:Cells, Cultured; D003470:Culture Media; D005600:Fragile X Syndrome / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008297:Male; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D012854:Sister Chromatid Exchange
D003470:Culture Media