Pharmacokinetics and serum concentrations of cephapirin in neonatal foals.
Six healthy foals, from 4 to 6 days of age, were given a single IM injection of sodium cephapirin (250 mg/ml) at a rate of 20 mg/kg of body weight. Serum concentrations of cephapirin were measured serially over an 8-hour period. The mean peak serum concentration was 21.2 micrograms/ml at 10 minutes. The overall elimination rate constant was 1.06/hr and the elimination half-life was 0.70 hour. The apparent volume of distribution at steady state was 1.06 L/kg and plasma clearance was 1,105 ml/hr/kg.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism*; D002514:Cephapirin / Q000097:blood / Q000378:metabolism*; D006736:Horses / Q000378:metabolism*; D007700:Kinetics
D002511:Cephalosporins; D002514:Cephapirin