Clearance and tissue distribution of functionalized polymeric liposomes from the blood stream of rats.
Polymeric liposomes containing a synthetic porphinato-iron-imidazole complex (hemoglobin or red blood cell model) were labeled by introducing 1,2-di[1-14C]palmitoyl-sn-glycero-3-phosphocholine into their polymerized bilayers. After intravenous injection into rats, their clearance from a blood stream was measured. The apparent half-life time (50% disappearance time) was about 14 +/- 2 h. Their tissue distribution was determined with time by whole autoradiographic measurement.
D000818:Animals; D001345:Autoradiography; D006207:Half-Life; D006418:Heme; D007093:Imidazoles; D008081:Liposomes / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D011108:Polymers; D011663:Pulmonary Surfactants; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D007093:Imidazoles; D008081:Liposomes; D011108:Polymers; D011663:Pulmonary Surfactants; D006418:Heme