Recovery of cortical acetylcholine output after ganglioside treatment in rats with lesion of the nucleus basalis.
The changes in acetylcholine release from the cerebral cortex induced by a unilateral electrolytic lesion of the nucleus basalis and by a treatment with GM1 monosialoganglioside (30 mg/kg i.p. for 20 days) were investigated. Acetylcholine release was measured using the cortical cup technique in rats transected at midpontine level. In the lesioned rats treated with saline an ipsilateral 38% decrease in acetylcholine release was observed. GM1 treatment prevented the decrease and brought about a 30% contralateral increase. These results indicate that GM1 induces a functional recovery of the cholinergic neurons ascending to the cortex.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001479:Basal Ganglia; D001925:Brain Damage, Chronic / Q000188:drug therapy*; D002540:Cerebral Cortex / Q000378:metabolism; D005732:Gangliosides / Q000627:therapeutic use*; D008297:Male; D009434:Neural Pathways; D051381:Rats; D011919:Rats, Inbred Strains; D013377:Substantia Innominata
D005732:Gangliosides; C025447:sialogangliosides; D000109:Acetylcholine