title: [Use of intrapleural doxycycline via lavage-drainage in recurrent effusions of neoplastic origin].
abstract: 27 patients (17 F, 10 M) with a mean age of 65 +/- 11 years and suffering from recurrent pleural effusions were treated with locally administered Doxycycline by lavage-drainage to achieve pleural symphysis (17 adeno-carcinomas, 3 large cell carcinomas; 3 epidermoid cancers; 3 non-Hodgkin's lymphoma; 1 small cell carcinoma). The solution used was a dilution of 50 ml doxycycline in 250 cc of isotonic saline. 22 of the 27 patients could be evaluated long term, 5 were lost to follow up, of whom two had recurred straight away despite local treatment. An immediate response was obtained in 23 out of the 28 patients (85%). Later the absence of recurrence was seen in 90% of the patients evaluated. The incidence of antimitotic therapy did not seem to be the determining factor in the 7 patients who received this in parallel. The duration of drainage was 11 +/- 6 days, the local treatment was well tolerated in the majority of cases. The use of the technique of lavage-drainage of doxycycline could be an alternative in those patients with a malignant pleural effusion whose general condition contra-indicates a symphysis under pleuroscopy.
mesh_terms: D000368:Aged; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D004322:Drainage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010994:Pleura; D010996:Pleural Effusion / Q000188:drug therapy / Q000209:etiology; D010997:Pleural Neoplasms / Q000150:complications / Q000188:drug therapy*; D012008:Recurrence; D007507:Therapeutic Irrigation
chemical_list: D004318:Doxycycline
vernacular_title: Utilisation de la doxycycline intrapleurale par lavage-drainage dans les épanchements récidivants d'origine néoplasique.