Effects of indeloxazine hydrochloride (YM-08054) on anoxia.
Effects of indeloxazine hydrochloride [(+/-)-2-[(inden-7-yloxy)methyl]morpholine hydrochloride, YM-08054] on anoxia were examined. Indeloxazine significantly prolonged survival time of mice subjected to anoxia and improved anoxia-induced impairment of the passive and active avoidance learnings in rats. Indeloxazine at doses inducing anti-anoxic actions showed no effect on cerebral blood flow in cats and pentobarbital sleeping time in mice. Therefore, anti-anoxic actions of indeloxazine are not attributable to cerebral vasodilative or central depressant activities. Calcium hopantenate (cerebral metabolic enhancer) also showed anti-anoxic actions, whereas neither viloxazine, amitriptyline (antidepressant) nor dihydroergotoxine (cerebral vasodilator) showed any effect on anoxia. These results suggest that indeloxazine possesses anti-anoxic activities similar to calcium hopantenate. The mode of anti-anoxic actions of indeloxazine is also discussed.
D000639:Amitriptyline / Q000627:therapeutic use; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004088:Dihydroergotoxine / Q000627:therapeutic use; D005260:Female; D000860:Hypoxia / Q000401:mortality / Q000517:prevention & control* / Q000523:psychology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009025:Morpholines / Q000627:therapeutic use*; D010205:Pantothenic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D010879:Piperazines / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013997:Time Factors; D014745:Viloxazine / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000627:therapeutic use
D009025:Morpholines; D010879:Piperazines; D004088:Dihydroergotoxine; D000639:Amitriptyline; C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid; D014745:Viloxazine; C026896:cinepazide; C020852:indeloxazine