title: [Clinical picture and various questions concerning the pathogenesis and prevention of complications of teturam therapy of alcoholic patients].
abstract: A comprehensive clinical, therapeutical, laboratory, and follow-up examination of 239 patients with chronic alcoholism has made it possible not only to specify the structure and proportion of complications associated with teturam therapy but also to validate an important role of disorders of the acid-base and water-electrolyte balance (levels of potassium and sodium in the plasma and red blood cells and the volume of the circulating blood and its components) in the pathogenesis of chronic alcoholism and in complications of teturam therapy. The results of examination have evidenced that the initial parameters of the acid-base equilibrium, the volume of the circulating blood and electrolyte balance may serve as prognostic signs indicating the possibility of the development of teturam therapy complications. The authors validate an important role of correction of pathological changes in hemostatic parameters for the prevention of teturam therapy complications, and outline differential routes of prophylaxis depending on the severity of the above pathological shifts determined by biochemical, pathophysical, and clinical parameters of the disease.
mesh_terms: D000137:Acid-Base Imbalance / Q000139:chemically induced*; D000328:Adult; D000437:Alcoholism / Q000188:drug therapy*; D000787:Angina Pectoris / Q000139:chemically induced; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced; D001810:Blood Volume; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D004221:Disulfiram / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008875:Middle Aged; D012769:Shock / Q000139:chemically induced*; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced*
chemical_list: D004221:Disulfiram
vernacular_title: Klinika, nekotorye voprosy patogeneza i profilaktika oslozhneniĭ teturamoterapii bol'nykh alkogolizmom.