Effect of zinc and/or pyridoxine deficiency upon oestrogen retention and oestrogen receptor distribution in the rat uterus.
A deficiency of vitamin B6 has been reported to enhance oestrogen responsiveness of the uterus in rats whereas zinc deficiency provokes a syndrome suggestive of a diminution in oestrogen sensitivity. In this study [3H]oestrogen uptake by the uterus was increased in rats deficient in either nutrient and the differences were additive in the dually deficient animals. The total number of oestrogen receptors per g tissue was unaffected by either nutrient but the proportion of the receptors recovered from the nuclear fraction increased from about 6 to 74% when both nutrients were withheld. The results are consistent with the hypothesis that both zinc and pyridoxal phosphate play important metabolic roles in end-organ responsiveness to oestrogen.
D000818:Animals; D001835:Body Weight; D004435:Eating; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D011732:Pyridoxal Phosphate / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D011960:Receptors, Estrogen / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism*; D026681:Vitamin B 6 Deficiency / Q000378:metabolism*; D015032:Zinc / Q000097:blood / Q000172:deficiency*
D011960:Receptors, Estrogen; D004958:Estradiol; D011732:Pyridoxal Phosphate; D015032:Zinc