Action of T-2 toxin on gastrointestinal transit in mice: protective effect of an argillaceous compound.
Using sodium [51Cr]chromate as radiolabeled marker, gastrointestinal transit of a milk test meal was determined in mice receiving for 4 days T-2 toxin (1 mg/kg per day per os) alone or with a clay, smectite (2 g/kg per day), given according to four different procedures. Gastric emptying and small intestinal transit were significantly accelerated after the 1st T-2 administration and during the 4 days of treatment. When smectite was given together with the toxin with or without pretreatment by smectite alone for 2 days, the T-2 induced disturbances in gastrointestinal transit remained unchanged. A pretreatment by smectite for 4 days abolished the T-2 induced acceleration of gastric emptying but not of small intestinal transit. When T-2 was incubated with smectite for 24 h before oral administration, gastric emptying and small intestinal transit were not significantly accelerated.
D000818:Animals; D002840:Chromates; D002860:Chromium Radioisotopes; D004063:Digestion / Q000187:drug effects*; D005746:Gastric Emptying / Q000187:drug effects; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008892:Milk; D012717:Sesquiterpenes / Q000494:pharmacology*; D017640:Silicates; D017670:Sodium Compounds; D013605:T-2 Toxin / Q000494:pharmacology*
D002840:Chromates; D002860:Chromium Radioisotopes; D005765:Gastrointestinal Agents; D012717:Sesquiterpenes; D017640:Silicates; D017670:Sodium Compounds; C028982:sodium chromate(VI); C033214:Smectite; D013605:T-2 Toxin