title: A two-stage test for ordered means in the poisson case with an example from mutagenicity testing.
abstract: It is shown how two-stage methods developed for continuous distributions can be used to construct two-stage tests for certain hypotheses pertaining to discrete distributions. Specifically, a two-stage test for ordered means in the Poisson case is presented. An example from mutagenicity testing is discussed and data from it are used to illustrate the methodology. Results of a Monte Carlo power study are presented as well as a brief table of critical values.
mesh_terms: D000818:Animals; D001699:Biometry; D001853:Bone Marrow; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D009010:Monte Carlo Method; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D051381:Rats
chemical_list: D009153:Mutagens