[Ultrastructural changes in the sarcolemma in the early stages of immune damage to the heart].
Early ultrastructural alterations were studied in cardiomyocyte sarcolemma on the model of acute local immune injury after the treatment of the dog's heart with anticardiac cytotoxic serum. It has been shown that immunotherapy results in the formation of numerous liposomal structures originating from the membrane material and located in subsarcolemmal space and near cardiomyocyte mitochondria. Depending on the method of fixation liposomes had the form of circular membrane vesicles or multilaminar structures. The structure and location of these liposomes near plasmalemma or mitochondrial membranes and sarcoplasmic reticulum have led to the assumption that they originate from unstable membrane phospholipids. The present data give evidence of the early and rapid phospholipid degradation in cardiomyocyte membranes during immune heart damage.
D000707:Anaphylaxis / Q000276:immunology / Q000473:pathology; D000818:Animals; D000937:Antigen-Antibody Reactions; D002463:Cell Membrane Permeability; D004285:Dogs; D007106:Immune Sera / Q000633:toxicity*; D008563:Membrane Lipids / Q000378:metabolism; D009206:Myocardium / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure*; D010743:Phospholipids / Q000378:metabolism; D012508:Sarcolemma / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure*; D013997:Time Factors
D007106:Immune Sera; D008563:Membrane Lipids; D010743:Phospholipids
Ul'trastrukturnye izmeneniia sarkolemmy na rannikh stadiiakh immunnogo povrezhdeniia serdtsa.