Chemical modifications of bafilomycin-type 16-membered dienlactone macrolides.
Derivatives of the 16-membered dienlactone bafilomycins were prepared in order to study the structure-activity relationship of these compounds. Some derivatives formed by hydrolysis, O-alkylation, O-acylation, trans-esterification and epoxidation were isolated and their structures determined by two-dimensional (2D) NMR studies and mass spectroscopy.
D000215:Acylation; D000478:Alkylation; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000302:isolation & purification; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006868:Hydrolysis; D007783:Lactones / Q000138:chemical synthesis / Q000302:isolation & purification; D018942:Macrolides; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D007783:Lactones; D018942:Macrolides; C040929:bafilomycin A1; C052501:bafilomycin B1; C052502:bafilomycin C1