title: Bony ossicular fixation using 2-cyano-butyl-acrylate adhesive.
abstract: We investigated the effects of 2-cyano-butyl-acrylate (Histoacryl) on the ossicles of 11 of 12 adult guinea pigs. A small amount of the adhesive, placed precisely between the incus and its bony fossa in each middle ear, fixed the ossicles. Light microscopic investigation of the ears of animals killed at 3, 6, 9, and 12 months after surgery showed a bony union of the ossicle to its surrounding niche in 11 of 12 operated-on ears. Negligible inflammatory reaction was seen in areas of the middle ear not in contact with the adhesive. These observations suggest that 2-cyano-butyl-acrylate may be used to achieve a durable bony union in ossiculoplastic surgery with minimal side effects in the middle ear.
mesh_terms: D000818:Animals; D004429:Ear Ossicles / Q000473:pathology / Q000601:surgery; D004659:Enbucrilate; D006168:Guinea Pigs; D007249:Inflammation / Q000473:pathology; D014014:Tissue Adhesives
chemical_list: D014014:Tissue Adhesives; D004659:Enbucrilate