Pharmacological properties of musk.
The general pharmacological properties of musk were studied. After the application of musk, inhibition of acetic acid-induced writhing, hemolytic effect and excitation of spontaneous uterine motility of rats, inhibition of spontaneous motility in isolated ileum of rabbits, and anti-inflammatory effects and potentiation of beta-adrenergic action in isolated preparations of guinea pig trachea were observed. These effects were not observed after application of muscone or allantoin, constituents of musk.
D000481:Allantoin / Q000494:pharmacology; D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants; D003516:Cycloparaffins / Q000494:pharmacology; D004064:Digestive System / Q000187:drug effects; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009132:Muscles / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D000700:Analgesics; D000927:Anticonvulsants; D003516:Cycloparaffins; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; C008563:musk; D000481:Allantoin; C031021:muscone