Effects of puromycin on rat embryos in vitro.
Somite-staged rat embryos were exposed to varying concentrations of puromycin for 48 h in vitro. Medium concentrations below 0.92 microM had no significant effects, while concentrations above 1.84 microM were lethal. Between these extremes, there were concentration dependent increases in the incidence of malformations in a close relationship to growth retardation.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects*; D011691:Puromycin / Q000494:pharmacology / Q000633:toxicity*; D051381:Rats
D011691:Puromycin