Foetal distribution of inhaled mercury vapor in normal and acatalasaemic mice.
Levels of mercury distribution in placenta, amniotic sac and foetus and those in brain and liver of maternal acatasaemic mice were higher than those of normal, respectively. The levels of mercury distribution in the blood and lungs of maternal acatalasaemic mice exposed to metallic mercury vapor were also lower than those of normal. Mercury concentrations in placenta and foetus of acatalasaemic mice following exposure to metallic mercury vapor were higher than those of normal. Maternal acatalasaemic mice had decreased levels of mercury in the blood than those of normal mice. Thus, the placenta/blood or foetus/blood ratio of mercury concentration in acatalasaemic mice was significantly higher than that in normal mice. Similarly the brain/blood or liver/blood ratio of maternal acatalasaemic mice was higher than that of normal mice. These results suggest that metallic mercury in the blood readily passed through the blood-brain, blood-foetus barriers. In contrast to the results on exposures of mice to metallic mercury, the foetus/maternal blood ratio of mercuric concentration in the acatalasaemic mice following injection of mercuric chloride was similar to that in the normal mice. Moreover, the foetus/maternal blood ratio of mercury concentration in acatalasaemic or normal mice injected with mercuric chloride was lower than those in acatalasaemic or normal mice exposed to metallic mercury.
D020642:Acatalasia; D000336:Aerosols; D000818:Animals; D002374:Catalase / Q000097:blood; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D008627:Mercuric Chloride / Q000633:toxicity; D008628:Mercury / Q000097:blood / Q000378:metabolism*; D008631:Mercury Radioisotopes; D051379:Mice; D008809:Mice, Inbred C3H; D011247:Pregnancy
D000336:Aerosols; D008631:Mercury Radioisotopes; D008627:Mercuric Chloride; D002374:Catalase; D008628:Mercury