Radioiodinated Rhodamine-123: a potential cationic hepatobiliary imaging agent.
The labelling of the cationic dye Rhodamine-123 with 125I is described. The biodistribution of the iodinated Rhodamine-123 has been determined at different time intervals after intravenous injection into fasted rats. It turned out that the dye is predominantly cleared by the liver and discharged into the bile. The bile acid taurocholate did not enhance the rate of excretion of 125I-Rhodamine-123.
D000818:Animals; D001659:Biliary Tract / Q000000981:diagnostic imaging*; D055598:Chemical Phenomena; D002621:Chemistry; D004064:Digestive System / Q000378:metabolism; D019793:Fluorescein; D005452:Fluoresceins / Q000378:metabolism / Q000652:urine; D007457:Iodine Radioisotopes / Q000097:blood / Q000652:urine; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging*; D009994:Osmolar Concentration; D011859:Radiography; D051381:Rats; D020112:Rhodamine 123; D012235:Rhodamines / Q000097:blood / Q000652:urine; D013656:Taurocholic Acid / Q000494:pharmacology; D013997:Time Factors; D014966:Xanthenes
D005452:Fluoresceins; D007457:Iodine Radioisotopes; D012235:Rhodamines; D014966:Xanthenes; D020112:Rhodamine 123; D013656:Taurocholic Acid; D019793:Fluorescein