Analysis of multicomponent formulations containing pseudoephedrine HCl and chlorpheniramine maleate using first-derivative spectroscopy on a diode-array spectrophotometer.
Pseudoephedrine HCl and chlorpheniramine maleate are compounds which have overlapping UV spectra in solutions of phosphate buffer (pH 7.2), water, and 0.1 M HCl. The quantitation of both compounds was achieved by using first-derivative spectroscopy on a diode-array spectrophotometer. The application of this method for the analysis of content uniformity testing and measuring dissolution profiles was demonstrated.
D002214:Capsules / Q000032:analysis; D002744:Chlorpheniramine / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations / Q000032:analysis; D004338:Drug Combinations; D004809:Ephedrine / Q000032:analysis*; D008838:Microcomputers; D013056:Spectrophotometry, Ultraviolet / Q000295:instrumentation / Q000379:methods; D013607:Tablets / Q000032:analysis
D002214:Capsules; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D013607:Tablets; D002744:Chlorpheniramine; D004809:Ephedrine