Anti-ulcer and membrane stabilizing actions of zinc acexamate.
The effects of zinc acexamate on stress and reserpine ulcers as well as on gastric mast cells degranulation and membrane stability were evaluated in the rat. Zinc acexamate (100 mg/kg) has demonstrated an inhibitory effect on cold-restraint stress and reserpine-induced ulcer in a dose-dependent manner. Pretreatment of rats, prior to cold restraint stress, reduced gastric mast cell degranulation. Zinc acexamate (10(-4) M) inhibits Triton X-100 release of beta-glucuronidase in isolated hepatic lysosomes. These observations suggest that ulcer protective actions of zinc acexamate may be exerted in part through enhancing gastric mucosal resistance by stabilizing biological membrane integrity.
D000614:Aminocaproates / Q000494:pharmacology*; D015119:Aminocaproic Acid / Q000494:pharmacology*; D000818:Animals; D000897:Anti-Ulcer Agents; D000933:Antifibrinolytic Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D003080:Cold Temperature; D003594:Cytoplasmic Granules / Q000187:drug effects; D005260:Female; D008247:Lysosomes / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000633:toxicity; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control
D000614:Aminocaproates; D000897:Anti-Ulcer Agents; D000933:Antifibrinolytic Agents; C018802:6-acetylaminocaproic acid; D012110:Reserpine; D015119:Aminocaproic Acid