[Biotransformation and pharmacokinetics of bamipine in rats. 2. Pharmacokinetics (P 2)].
After oral application pharmacokinetic parameters of N-phenyl-N-benzyl-4-amino-1-methylpiperidin (bamipine) were investigated. The curve of the plasma level is characterized by two maxima. If the first maximum is neglected, the calculated elimination half-life is 9.52 h, the invasion half-life 1.03 h. The first maximum is calculated as a lag-time (1.62 h). By whole-body radiography of the animal an accumulation of activity was determined in the glandular tissues behind the eye--beside the usual accumulation of activity in liver, spleen, kidney and lung.
D000284:Administration, Oral; D000818:Animals; D001345:Autoradiography; D001711:Biotransformation; D007700:Kinetics; D008297:Male; D010880:Piperidines / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D010880:Piperidines; C020867:bamipine
Biotransformation und Pharmakokinetik von Bamipin an Ratten. 2. Mitteilung: Untersuchungen zur Pharmakokinetik (2. Teil).