Essential fatty acids in serum lecithin of children with atopic dermatitis and in umbilical cord serum of infants with high or low IgE levels.
The fatty acid composition of serum lecithin from children with atopic dermatitis (AD) was found to be abnormal, characterized by significantly increased proportion of linoleic acid and reduced levels of metabolites of this fatty acid. The levels of linoleic acid in umbilical cord serum lecithin were significantly higher in babies with high serum IgE than in those with low or non-demonstrable serum IgE. Since elevated cord serum IgE is strongly associated with development of atopic disease the results suggest that fatty acid changes may be a basic feature of AD. Immunologic dysfunction in patients with AD may possibly partly be a consequence of the fatty acid abnormality.
D002648:Child; D003876:Dermatitis, Atopic / Q000097:blood*; D005228:Fatty Acids, Essential / Q000097:blood*; D005312:Fetal Blood / Q000032:analysis*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007231:Infant, Newborn; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000032:analysis; D010713:Phosphatidylcholines / Q000097:blood*
D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D010713:Phosphatidylcholines; D007073:Immunoglobulin E; D019787:Linoleic Acid