[Effect of radiomodifiers on lipid peroxidation and the structural-functional state of irradiated mitochondria].
SH-Containing radioprotective agents, for instance, cysteine, cystamine, dithiothreitol, exert an antioxidant effect on gamma-radiation-induced lipid peroxidation in mitochondrial membranes and, concurrently, uncouple oxidation from phosphorylation. A radiosensitizer, N-ethylmaleimide, on the contrary, being a pro-oxidant of lipid peroxidation couples oxidation and phosphorylation. At the same time, changes in the lipid peroxidation system and in the energy production processes, observed after irradiation of a mitochondrion suspension containing modifiers, are accompanied by the increased destruction of mitochondrial membranes as compared to irradiated controls.
D000818:Animals; D005720:Gamma Rays; D008054:Lipid Peroxides / Q000378:metabolism* / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D010084:Oxidation-Reduction / Q000187:drug effects / Q000528:radiation effects; D010085:Oxidative Phosphorylation / Q000187:drug effects / Q000528:radiation effects; D010101:Oxygen Consumption / Q000187:drug effects / Q000528:radiation effects; D011837:Radiation-Protective Agents; D013438:Sulfhydryl Compounds / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013997:Time Factors
D008054:Lipid Peroxides; D011837:Radiation-Protective Agents; D013438:Sulfhydryl Compounds
Vliianie radiomodifikatorov na perekisnoe okislenie lipidov i strukturno-funktsional'noe sostoianie obluchennykh mitokhondriĭ.