The antimetastatic activity of enkephalin-like peptides.
[Met5]Enkephalin and [Leu5]enkephalin, two naturally occurring opioid-like peptides were found to decrease the number of spontaneous pulmonary metastases in C57BL/6J mice implanted in the foot pad with the B16-BL6 melanoma. The number of such metastatic nodules were reduced more than 2-fold. This effect was noted after several different injection schedules. In addition to their effect on metastasis the growth rate of the primary tumor was also decreased by these compounds.
D000818:Animals; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin / Q000627:therapeutic use; D004743:Enkephalin, Leucine / Q000627:therapeutic use; D004744:Enkephalin, Methionine / Q000627:therapeutic use; D004745:Enkephalins / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000517:prevention & control* / Q000556:secondary; D008545:Melanoma / Q000517:prevention & control* / Q000556:secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000517:prevention & control
D004745:Enkephalins; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin