title: Fragile sites, chromosome evolution, and human neoplasia.
abstract: In a study of the possible relationship between human fragile sites, chromosomal rearrangements related to neoplasia, and chromosome regions involved in evolutionary changes, we have found that 17 fragile sites related to cancer, 15 fragile sites not related to cancer, and 17 non-fragile regions also related to human malignancy correspond or are close to bands involved in rearrangements that have taken place during chromosomal evolution in primates.
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002869:Chromosome Aberrations; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D011323:Primates / Q000235:genetics*