[Free calcium concentrations in the nerve endings in the brain of rats with spontaneous hypertension].
Fluorescent indicator Quin-2 was used for the determination of free calcium (Ca2+in) in synaptosomes incubated in the normal medium and media where sodium is replaced by potassium or choline. At external calcium concentration of 1 mM, Ca2+in in all three media was 20-30% higher in synaptosomes of spontaneously hypertensive rats (SHR) than in control animals. At external calcium concentration of 5 mM, the increase in Ca2+in values induced by K+-depolarization in sodium- or choline-containing media was 50-80% higher in synaptosomes of SHR. These differences are suggested to be the basis for the mechanism of increased peripheral chain activity in the sympathetic nervous system in primary hypertension.
D000634:Aminoquinolines; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D005456:Fluorescent Dyes; D006973:Hypertension / Q000378:metabolism; D008297:Male; D009411:Nerve Endings / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism*; D011919:Rats, Inbred Strains / Q000378:metabolism*; D011921:Rats, Inbred WKY; D013574:Synaptosomes / Q000378:metabolism
D000634:Aminoquinolines; D005456:Fluorescent Dyes; C035739:Quin2; D002118:Calcium
Kontsentratsiia svobodnogo kal'tsiia v nervnykh okonchaniiakh golovnogo mozga krys so spontannoĭ gipertenzieĭ.