title: Interferon-beta can induce the production of plasminogen activator by cultured human cancer cells.
abstract: Three cultured human cell lines, renal cancer cells (ACHN), bladder cancer cells (EJ), and fibroblasts transformed in culture by Co-60 gamma rays (KMST-6), when treated with interferon-beta, produced 1.5 to 4 times as much plasminogen activator as the untreated control cultures. This enhanced production of PA was inhibited by cycloheximide or actinomycin D.
mesh_terms: D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D006801:Humans; D007370:Interferon Type I / Q000502:physiology*; D007680:Kidney Neoplasms / Q000378:metabolism; D007700:Kinetics; D009369:Neoplasms / Q000378:metabolism*; D009381:Neoplasms, Radiation-Induced / Q000378:metabolism; D010960:Plasminogen Activators / Q000096:biosynthesis*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism
chemical_list: D007370:Interferon Type I; D003609:Dactinomycin; D003513:Cycloheximide; D010960:Plasminogen Activators