Polymorphonuclear leucocyte function and previous yersinia arthritis: enhanced chemokinetic migration and oxygen radical production correlate with the severity of the acute disease.
Polymorphonuclear leucocyte (PMN) functions (migration in vitro, chemiluminescence, O-2 production, binding of chemotactic peptide, and aggregation) were studied in HLA-B27 positive patients with previous yersinia arthritis (YA). PMNs of patients whose disease had been severe showed chemokinetic and chemiluminescence responses significantly higher than the PMNs of those with a mild disease. The results support the view that enhanced PMN function contributes to inflammatory symptoms in patients with YA.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001170:Arthritis, Infectious / Q000097:blood*; D002449:Cell Aggregation; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D005260:Female; D005609:Free Radicals; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000378:metabolism; D009504:Neutrophils / Q000473:pathology*; D010100:Oxygen / Q000097:blood; D015009:Yersinia Infections / Q000097:blood*
D005609:Free Radicals; D009240:N-Formylmethionine Leucyl-Phenylalanine; D010100:Oxygen