title: The formation of "compartment replicas" in the lymph nodes of athymic animals.
abstract: This communication describes a new anomaly that can affect the capsule of lymph nodes of athymic animals. Lymphocytes infiltrate a segment of the capsule above the variably atrophied peripheral cortex overlying the center of the deep-cortex unit of a node compartment. Lymphocytes thereafter form a capsular mass. The developing mass of lymphocytes is invaded by outgrowths of the node's subcapsular sinus while it fuses with the parenchyma of the related node compartment. Eventually, this new nodal element acquires structures resembling those of nodes and becomes a more or less exact replica of the original node compartment. Replicas stem from node compartments that are overchallenged by uncontrolled antigens. Aspects of the formation of replicas are explained by recent findings on events occurring in nodes of athymic animals and on the pattern of antigen distribution in the subcapsular sinus of a node. It is concluded that the formation of a compartment replica constitutes a mechanism allowing the organism to compensate somewhat for the partial atrophy or deficiency of a node compartment.
mesh_terms: D000375:Aging; D000818:Animals; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D008198:Lymph Nodes / Q000254:growth & development* / Q000473:pathology; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D051381:Rats; D011922:Rats, Mutant Strains; D011923:Rats, Nude