Energy requirements of erythrocytes under mechanical stress.
Factors influencing an increase of glucose consumption in erythrocytes under mechanical stress were studied. Under the shear stress of 2000-5000 s-1 the glucose consumption goes up 20-50%. This effect disappears in protein-free media, in Ca2+-free media and in resealed red ghosts; in all these cases certain morphological deviations were observed in the stressed cells. These results confirm the vital role of energy-consuming contractile apparatus of erythrocyte membrane in restoration of the smooth biconcave shape after deformation.
D001786:Blood Glucose / Q000378:metabolism; D004734:Energy Metabolism; D004907:Erythrocyte Deformability; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D011770:Pyruvate Kinase / Q000172:deficiency; D013314:Stress, Mechanical
D001786:Blood Glucose; D011770:Pyruvate Kinase