[Changes in the microflora of the large intestine in rats administered cephalexin and erythromycin orally].
The effect of long-term use of cephalexin and erythromycin (for 17 days) on large intestine microflora was studied on rats. It was found that intragastric administration of cephalexin in a dose of 800 mg/kg and erythromycin in a dose of 400 mg/kg was followed by changes in the quantitative and qualitative composition of the large intestine aerobic and anaerobic microflora. However, it did not induce production of beta-aspartyl glycine which is a biochemical indicator of deep changes in intestinal microflora. The long-term use of the above antibiotics resulted in increased levels and persistence of intestine colonization with facultative pathogenic enterobacteria and staphylococci resistant to the chemotherapeutic agents.
D000284:Administration, Oral; D000818:Animals; D002506:Cephalexin / Q000008:administration & dosage*; D004151:Dipeptides / Q000032:analysis; D004463:Ecology; D004917:Erythromycin / Q000008:administration & dosage*; D005243:Feces / Q000032:analysis / Q000382:microbiology; D005260:Female; D007420:Intestine, Large / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
D004151:Dipeptides; C018459:beta-aspartylglycine; D004917:Erythromycin; D002506:Cephalexin
Izmenenie mikroflory tolstoĭ kishki krys pri oral'nom vvedenii tsefaleksina i éritromitsina.