title: [Treatment by prostaglandin E1 of isolated coarctations in newborn infants with acute cardiac failure].
abstract: In neonates with isolated coarctation of the aorta presenting with acute neonatal heart failure refractory to classical treatment, emergency surgery is associated with a 30% death-rate. We rather suggest to add to treatment a perfusion of prostaglandin E1 in order to dilate the ductus arteriosus and thereby the aortic isthmus. This was performed successfully in 9 of 12 neonates aged 5 to 16 days: coarctation was relieved and heart failure disappeared. As soon as the left ventricle became hyperkinetic again (2 to 6 days later), prostaglandin was discontinued. Coarctation reappeared with either chronic heart failure (3 cases) or severe arterial hypertension (5 cases). Eventually one child recovered without surgery and the other 11 were operated on at an average age of 24 days, with only one death.
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage*; D001017:Aortic Coarctation / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010477:Perfusion
chemical_list: D000527:Alprostadil
vernacular_title: Traitement par la prostaglandine E1 des coarctations isolées du nouveau-né en défaillance cardiaque aiguë.