Effects of low dietary intake of methionine, choline or proteins on the biotransformation of arsenite in the rabbit.
The effects of 6 weeks feeding with diets low in methionine, choline, or proteins on the biotransformation and retention of 76As-labelled arsenite (0.4 mg As/kg bw) in rabbits have been studied. All test diets caused a significant decrease in the urinary excretion of dimethyl[76As]-arsinic acid, the main metabolite of inorganic arsenic. This gave rise to an increased retention of arsenic in the tissues, especially liver and lung. The test diets also caused a specific increase of the arsenic concentration in liver microsomes. The results indicate that subjects with a poor nutritional status have a lower capacity of methylating and thereby detoxifying inorganic arsenic.
D000818:Animals; D001151:Arsenic / Q000378:metabolism*; D018053:Arsenites; D001711:Biotransformation; D002794:Choline / Q000008:administration & dosage*; D004032:Diet; D004044:Dietary Proteins / Q000008:administration & dosage*; D008297:Male; D008715:Methionine / Q000008:administration & dosage*; D008745:Methylation; D011817:Rabbits; D014018:Tissue Distribution
D018053:Arsenites; D004044:Dietary Proteins; D008715:Methionine; C015001:arsenite; D001151:Arsenic; D002794:Choline