Lysozyme secreting tumor: a case of gastric cancer associated with myelofibrosis due to disseminated bone marrow metastasis.
One patient with gastric carcinoma and secondary myelofibrosis due to disseminated bone marrow metastasis had markedly elevated lysozyme (LZM) levels in serum and urine with the intense presence of LZM within tumor tissues. It is considered to be a case of gastric carcinoma with LZM secreting functional capacities. To date, there were many reported cases to verify the LZM positive cells by LZM staining in the tissue of gastric carcinoma and to demonstrate the elevated serum levels of LZM in malignant tumor bearing patients, whereas no papers to disclose the elevated levels of LZM in serum and urine originated from the productions and secretions of gastric carcinoma cells. So, this report might be the first reported case of LZM secreting tumor verified by LZM staining of carcinoma cells except for haematological malignancies such as acute monocytic leukemia or myelomonocytic leukemia.
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000473:pathology / Q000556:secondary*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000097:blood / Q000378:metabolism* / Q000652:urine; D055728:Primary Myelofibrosis / Q000209:etiology*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
D009113:Muramidase