title: Spinal block, after dantrolene pretreatment, for resection of a thigh muscle herniation in a young malignant hyperthermia susceptible man.
abstract: We describe a young man who experienced malignant hyperpyrexia, probably triggered by suxamethonium and/or enflurane during his second operation for an epigastric hernia. His malignant hyperthermia susceptibility was later verified using the caffeine/halothane contracture test in vitro. Subsequently, a tumorous mass, consisting of herniated and hypertrophied muscle grew in his thigh, and was resected under spinal anaesthesia. Whereas dantrolene (2.5 mg/kg i.v.) pretreatment produced impaired swallowing, the subsequent high spinal block, in addition, resulted in laboured breathing. It is stressed that respiratory power should be monitored when patients pretreated with dantrolene are given spinal anaesthesia. The muscular symptoms and test results in the patient's relatives are also discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000775:Anesthesia, Spinal; D002648:Child; D003620:Dantrolene / Q000627:therapeutic use*; D004198:Disease Susceptibility; D059685:Herniorrhaphy; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000517:prevention & control*; D009135:Muscular Diseases / Q000601:surgery*; D011229:Preanesthetic Medication; D013848:Thigh
chemical_list: D003620:Dantrolene