Positive intravenous secretin test in patients with achlorhydria-related hypergastrinemia.
The intravenous secretin test is widely used to distinguish gastrinoma (Zollinger-Ellison syndrome) from other causes of fasting hypergastrinemia. We report 2 patients with fasting hypergastrinemia and a rise of greater than 200 pg/ml in serum gastrin concentration after intravenous injection of 2 CU/kg body wt of pure natural secretin. Both patients had pentagastrin-fast achlorhydria. Thus, the intravenous secretin test may be positive in patients with achlorhydria-related hypergastrinemia. Gastric acid secretion should be measured in hypergastrinemic patients before embarking on a secretin test.
D000126:Achlorhydria / Q000097:blood*; D003429:Cross Reactions; D005189:False Positive Reactions; D005260:Female; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D012633:Secretin; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000175:diagnosis*
D005755:Gastrins; D012633:Secretin