Potent vasoconstrictor responses to endogenous digitalis-like factor of isolated, perfused dog intermediate auricular arteries.
Endogenous digitalis-like factor obtained from urine of hypertensive patients caused a vasoconstriction in a dose-related manner in isolated, perfused dog intermediate auricular arteries. The constriction was not modified by alpha-adrenoceptor blockade.
D000818:Animals; D001158:Arteries; D001798:Blood Proteins / Q000494:pharmacology*; D002298:Cardenolides; D004077:Digoxin; D004285:Dogs; D004423:Ear / Q000098:blood supply; D006801:Humans; D006973:Hypertension / Q000652:urine; D012503:Saponins; D014661:Vasoconstriction / Q000187:drug effects*
D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin