title: Pharmacokinetics of besulpamide in rats and dogs.
abstract: The pharmacokinetics of besulpamide were studied in rats and its urinary excretion in rats and dogs. Kinetic characteristics were the same for both male and female rats according to a two-compartment open model. Biological half-life was 1-4 hr, absorption half-life was approximately 10 min and absolute bioavailability was nearly complete (F = 86.4%). In rats, urinary excretion of unchanged besulpamide was 30% after i.v. administration and 7% after oral administration, whereas in dogs after oral administration it was 54%. Values of the area under the plasma concentration-time curve in rats and percent of urinary excretion in dogs show that the kinetics of besulpamide are not dose-related when the drug is administered at doses of 10-50 mg/kg.
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000378:metabolism*; D001682:Biological Availability; D004232:Diuretics / Q000378:metabolism*; D004285:Dogs; D005260:Female; D007700:Kinetics; D008297:Male; D011726:Pyridinium Compounds / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D011726:Pyridinium Compounds; C052513:besulpamide