Serotonin (5-HT) uptake by blood platelets in anorexia nervosa.
Platelet serotonin (5-HT) uptake was determined in 15 underweight anorexia nervosa patients and a control group of 15 healthy individuals. The Vmax (picomoles/10(8) platelets/5 min) was 424 +/- 103 in patients and 424 +/- 69 in controls. The Km was 1.19 +/- 0.2 microM in patients and 1.08 +/- 0.17 microM in controls. The differences between the groups were not significant. These findings do not support the hypothesis that serotonin metabolism is disturbed in anorexia nervosa.
D000856:Anorexia Nervosa / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D003866:Depressive Disorder / Q000097:blood; D005260:Female; D006801:Humans; D007700:Kinetics; D012701:Serotonin / Q000097:blood*
D012701:Serotonin