Intestinal absorption of aluminium from antacids: a comparison between hydrotalcite and algeldrate.
The intestinal absorption of aluminium (Al) from the antacid hydrotalcite (Ultacit) was compared with that from algeldrate (Algeldratum des-acidans) in 8 healthy human subjects in a cross-over study. The level of Al in serum (AlS) was increased in 7 out of 8 subjects 7 hr after intake of 6 g algeldrate while AlS did not rise after intake of 8 g hydrotalcite--a dose with at least comparable acid-neutralizing capacity--in any of the subjects.
D000328:Adult; D000535:Aluminum / Q000378:metabolism*; D000536:Aluminum Hydroxide / Q000378:metabolism*; D000863:Antacids / Q000378:metabolism*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008274:Magnesium / Q000378:metabolism*; D008276:Magnesium Hydroxide / Q000378:metabolism*; D008297:Male; D010865:Pilot Projects
D000863:Antacids; C010467:hydrotalcite; D000536:Aluminum Hydroxide; D000535:Aluminum; D008274:Magnesium; D008276:Magnesium Hydroxide