Tetrodotoxin enhances initial neurite outgrowth from fetal rat cerebral cortex cells in vitro.
The effect of two different concentrations of the sodium channel blocker tetrodotoxin on neurite outgrowth from fetal rat cerebral cortex neurons was studied in vitro. A concentration of 10(-6) M tetrodotoxin enhanced after two days in vitro: the percentage of isolated cells and reaggregates which formed neurites, the number of neurites per cell soma, and neurite elongation and subsequent branching. The effects observed after treatment with 10(-7) M tetrodotoxin were on the whole intermediate between control and 10(-6) M tetrodotoxin.
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology*; D002449:Cell Aggregation / Q000187:drug effects; D002478:Cells, Cultured; D009778:Occipital Lobe / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013779:Tetrodotoxin / Q000494:pharmacology*
D013779:Tetrodotoxin