Effects of alpha-chlorohydrin on the reproductive organs of the male bandicoot rat (Bandicota bengalensis).
The present study was undertaken to determine the effects of alpha-chlorohydrin at a dosage of 50, 100 or 150 mg/kg body weight and were killed 2 or 10 days later. alpha-chlorohydrin at employed dose levels induced selective damage to the germinal epithelium which seemed to be confined to one "cycle" only. No permanent epididymal lesions were observed in any of the treated bandicoots even following a toxic dose of the drug. Administration of this compound at a dose level of 50 or 100 mg/kg also had no effect on the weight of the testis or sex accessory organs or fructose levels in coagulating glands when compared to controls. These data indicate that the alpha-chlorohydrin possibly acts directly on the testis without influencing the normal endocrine status of the animal.
D000818:Animals; D002728:Chlorohydrins / Q000494:pharmacology*; D004822:Epididymis / Q000033:anatomy & histology / Q000187:drug effects; D005837:Genitalia, Male / Q000187:drug effects*; D008297:Male; D009115:Muridae; D009929:Organ Size; D010572:Pest Control, Biological; D012375:Rodent Control; D013076:Sperm Count; D013090:Spermatocytes; D013093:Spermatogonia; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects; D000517:alpha-Chlorohydrin / Q000494:pharmacology*
D002728:Chlorohydrins; D000517:alpha-Chlorohydrin