Skin inhibits cartilage proliferation and calcification. Tissue culture of fetal mice bones.
In an in vitro study, fetal mice metatarsal bones were cultured with skin or muscle fragments at some distance. We found that skin fragments inhibit growth in length and progress of calcification. Muscle fragments had no significant effects. Apparently, skin cells may produce factors that inhibit the development of metatarsal bones.
D000818:Animals; D001842:Bone and Bones / Q000166:cytology; D002113:Calcification, Physiologic; D002356:Cartilage / Q000166:cytology*; D002454:Cell Differentiation; D002455:Cell Division; D046508:Culture Techniques; D009132:Muscles / Q000166:cytology; D012867:Skin / Q000166:cytology*; D013997:Time Factors