Autoimmune oophoritis: a histopathologic study of involved ovaries with immunologic characterization of the mononuclear cell infiltrate.
The ovaries from a patient with autoimmune oophoritis and premature ovarian failure were extensively evaluated by light microscopy and immunohistochemistry. A marked infiltrate of plasma cells and lymphocytes affected developing, cystic and atretic follicles but spared primordial follicles. Immunotyping of the ovarian mononuclear cell infiltrate revealed a mixture of B cells (including plasma cells) and T cells (both T4+ and T8+), as well as numerous macrophages and a few natural killer cells. These findings suggest that a complex immune process with an interplay of humoral and cellular mechanisms is involved in the pathogenesis of autoimmune oophoritis.
D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D005260:Female; D006107:Granulosa Cells / Q000473:pathology; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D009869:Oophoritis / Q000276:immunology* / Q000473:pathology; D010048:Ovarian Cysts / Q000276:immunology / Q000473:pathology; D010053:Ovary / Q000276:immunology / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology