title: Non-interaction of ketotifen and theophylline in children with asthma--an acute study.
abstract: Six asthmatic children participated in an acute crossover randomized study. They received a single dose of aminophylline syrup 6 mg/kg after having received ketotifen syrup 1 mg b.i.d. or placebo for 8 days. Ketotifen did not significantly affect the heart rate, pulse pressure or such pharmacokinetic parameters of theophylline as peak serum level, time to peak, half life and AUC. Thus, ketotifen had no significant effect on the disposition of theophylline.
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D004347:Drug Interactions; D006207:Half-Life; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007665:Ketotifen / Q000009:adverse effects* / Q000627:therapeutic use; D012129:Respiratory Function Tests; D013806:Theophylline / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D013806:Theophylline; D007665:Ketotifen