The human insulin-like growth factor II gene contains two development-specific promoters.
The insulin-like growth factors (IGF) play an important role in fetal and postnatal development. Recently, the nucleotide sequences of the cDNAs encoding IGF-I and IGF-II and part of the human IGF genes were reported. In this communication we describe two distinct IGF-II cDNAs isolated from a human adult liver and a human hepatoma cDNA library, respectively. Using these two cDNAs, we have established that the human IGF-II gene contains at least 7 exons. Two different IGF-II promoters have been identified, 19 kilobases (kb) apart, which are active in a development-specific manner. The promoter, active in the adult stage, is located only 1.4 kb downstream from the insulin gene.
D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005091:Exons; D005786:Gene Expression Regulation; D006128:Growth; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D011401:Promoter Regions, Genetic; D013002:Somatomedins / Q000235:genetics*; D014158:Transcription, Genetic
D013002:Somatomedins; D007335:Insulin-Like Growth Factor II; D004247:DNA