Naloxone does not influence breathing during isoflurane anaesthesia.
Naloxone influences ventilation, probably by an action on endogenous opioids, in several conditions in which ventilation is reduced or impaired. Ventilatory depression is a feature of anaesthesia; some of the actions of anaesthetic drugs have been attributed to endogenous opioids. Naloxone was given to two groups of patients to investigate the possibility that ventilatory depression might be reversed. Patients breathed isoflurane in oxygen (1.5% end-tidal) or isoflurane in 67% nitrous oxide in oxygen (0.75% end-tidal) which are approximately equivalent MAC values. Naloxone 2 mg, i.v. given during surgery had no influence on ventilation or ventilatory timing in either group.
D000328:Adult; D000769:Anesthesia, Inhalation; D005260:Female; D006801:Humans; D007530:Isoflurane; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology*; D009609:Nitrous Oxide; D012119:Respiration / Q000187:drug effects*
D009270:Naloxone; D007530:Isoflurane; D009609:Nitrous Oxide