Reduction of body fat stores by inhibition of prolactin secretion.
Reductions of prolactin secretion by bromocriptine treatment for 24 days reduced fat stores (abdominal and epididymal fat depots) in hamsters by 25-49% compared with control animals. However, body weights and food consumption were not affected. These results further substantiate an important role for prolactin in regulation of fat metabolism and indicate that bromocriptine might be used to decrease fat stores.
D000273:Adipose Tissue / Q000033:anatomy & histology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001971:Bromocriptine / Q000494:pharmacology*; D006224:Cricetinae; D004435:Eating / Q000187:drug effects; D008055:Lipids / Q000096:biosynthesis; D008297:Male; D008647:Mesocricetus; D009929:Organ Size / Q000187:drug effects; D011388:Prolactin / Q000037:antagonists & inhibitors / Q000378:metabolism*
D008055:Lipids; D001971:Bromocriptine; D011388:Prolactin