Antineoplastic activity of azacarbazoles. III. Synthesis and antitumor evaluation of selected 2-, 3- aza- and diazaanalogues of carbazole.
Preliminary screening of the antitumor properties of selected azacarbazoles revealed that of all the compounds tested only 2,7-diazacarbazole (compound IX) and 3,6-diazacarbazole (compound XI) caused the inhibition of Sarcoma 180 growth up to 70%. beta- and gamma-Carbolines and their derivatives in presented testing system were inactive. None of the tested compounds displayed marked activity against murine leukemias and was active in the cytotoxicity test of KB cells.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007624:KB Cells; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D002227:Carbazoles