title: [Immunosuppressive therapy in clinical practice].
abstract: In clinical practice immunosuppressive therapy is performed by means of glucocorticoids in most patients. In addition, some patients are given alkylating agents (cytoxan, chlorambucil) or purine analogues (azathioprine). Recently a new immunosuppressive drug, cyclosporine A, has been developed. The mechanisms of action of these four compounds are discussed, for which purpose a simple model of the immunological network is presented. The present indications for the use of cyclosporine A in clinical practice are discussed.
mesh_terms: D000477:Alkylating Agents / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D002699:Chlorambucil / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D003524:Cyclosporins / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000477:Alkylating Agents; D003524:Cyclosporins; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D002699:Chlorambucil; D003520:Cyclophosphamide; D001379:Azathioprine
vernacular_title: Immunosuppressive Therapie in der Praxis.