Enantiomers of warfarin and vitamin K1 metabolism.
The effect of the individual enantiomers of warfarin at steady state (1 mg daily) was investigated in five healthy volunteers. Both enantiomers produced a significant increase in prothrombin time, but the increase with S warfarin (1.8 +/- 0.8 s, mean +/- s.d.) was greater than with R warfarin (1.0 +/- 0.3 s), despite lower steady state plasma concentrations of S warfarin, due to its more rapid clearance. Following the administration of vitamin K1, the maximum plasma concentration and area under the plasma concentration time curve values for the metabolite vitamin K1 2,3-epoxide were greater after S warfarin than after R warfarin. The greater anticoagulant potency of S warfarin is reflected by a greater degree of inhibition of vitamin K1 epoxide reductase.
D006207:Half-Life; D006801:Humans; D011517:Prothrombin Time; D013237:Stereoisomerism; D010837:Vitamin K 1 / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*; D014859:Warfarin / Q000097:blood / Q000494:pharmacology*
C016186:vitamin K1 oxide; D014859:Warfarin; D010837:Vitamin K 1