title: The carbohydrate specificity of conglutinin and its homology to proteins in the hepatic lectin family.
abstract: Inhibition experiments with D-mannose oligosaccharides establish that conglutinin recognises terminal alpha 1----2 mannobiosyl units present in the glycopeptide of the alpha-chain of the complement component C3b. On the basis of its three domain structure and the homology of its N-terminal amino-acid sequence to that of the dog pulmonary surfactant protein, it is proposed that conglutinin is a member of the hepatic lectin family.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002240:Carbohydrate Sequence; D002352:Carrier Proteins / Q000378:metabolism*; D002417:Cattle; D037222:Collectins; D003179:Complement C3b / Q000378:metabolism*; D037102:Lectins / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008351:Mannans / Q000378:metabolism*; D005810:Multigene Family; D009844:Oligosaccharides / Q000378:metabolism; D011663:Pulmonary Surfactants / Q000378:metabolism; D012712:Serum Globulins / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D002352:Carrier Proteins; D037222:Collectins; D037102:Lectins; D008351:Mannans; D009844:Oligosaccharides; D011663:Pulmonary Surfactants; D012712:Serum Globulins; C024014:conglutinin; D003179:Complement C3b; D002118:Calcium