[Carbachol-pentagastrin-induced duodenal ulcer in rats and its relation to gastric acid secretion].
Duodenal ulcers were produced in rats by the subcutaneous infusion of carbachol and pentagastrin in combination. We determined the gastric acid output using a perfusion method, when carbachol or pentagastrin were infused alone or in combination. In combination we saw a maximum acid output. Atropine blocked a carbachol stimulation totally but did not affect pentagastrin stimulation. Infusing rats subcutaneously with carbachol/pentagastrin and applicating atropine I.V. rats did not develop duodenal ulcer. This method of secretagogue produced duodenal ulcer is a model for study of anticholinergic influences of the gastric secretion.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002217:Carbachol; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000503:physiopathology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D007700:Kinetics; D010418:Pentagastrin; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D001285:Atropine; D002217:Carbachol; D010418:Pentagastrin
Das Carbachol-Pentagastrin-induzierte Ulcus duodeni der Ratte und seine Magensekretionsbedingungen.