title: Ultrastructural changes in the parenchymal liver cells of rats treated with high doses of rifampicin.
abstract: Ultrastructural study of hepatic parenchyma was carried out in female Wistar rats after they had received high doses (400 mg X kg-1) of rifampicin for 1, 2, 4, 6 and 8 days. Morphological changes in the endoplasmic reticulum, Golgi apparatus and mitochondria were observed as early as day 1 of intoxication. These changes corroborate the biochemical data available regarding RFP-induced fatty liver.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005234:Fatty Liver / Q000139:chemically induced*; D005260:Female; D006056:Golgi Apparatus / Q000648:ultrastructure; D008079:Lipoproteins, VLDL / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012270:Ribosomes / Q000648:ultrastructure; D012293:Rifampin / Q000633:toxicity*
chemical_list: D008079:Lipoproteins, VLDL; D012293:Rifampin