Linkage of the preimplantation-embryo-development (Ped) gene to the mouse major histocompatibility complex (MHC).
The preimplantation-embryo-development (Ped) gene influences the rate of cleavage division of preimplantation mouse embryos. The location of the Ped gene in the mouse major histocompatibility complex (MHC), the H-2 complex, has been inferred from the analysis of cleavage rates of embryos from mouse strains congenic at the H-2 complex. In this paper, formal genetic linkage studies were undertaken to evaluate linkage of the Ped gene to the H-2 complex. Co-segregation of Ped gene phenotype and H-2 haplotype was found in back-cross embryos. These data support the hypothesis that the Ped gene is linked to the H-2 complex.
D000818:Animals; D001755:Blastocyst / Q000166:cytology / Q000276:immunology*; D004624:Embryo Transfer; D005314:Embryonic and Fetal Development; D005260:Female; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics; D006239:Haplotypes; D008285:Major Histocompatibility Complex; D051379:Mice; D008810:Mice, Inbred C57BL; D010641:Phenotype; D011247:Pregnancy
D006183:H-2 Antigens