Regular stripe-like activation and suppression of metabolic activity in the cerebellar cortex following apomorphine administration to haloperidol-pretreated rats.
Alteration of the pattern of metabolic activity in the cerebellar cortex, as produced by apomorphine in rats given chronic pretreatment with haloperidol was studied by means of the [14C]deoxyglucose method. Apomorphine induced a regular stripe-like activation and suppression of metabolic activity in the caudal paravermal area of the cerebellar hemisphere and in the caudal vermis of the cerebellar cortex. This stripe-like pattern, oriented perpendicularly to the cerebellar fissure, suggests the functional organization of the cerebellar cortex in a direction which is parallel to the longitudinal axis of folia.
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage*; D001345:Autoradiography; D001522:Behavior, Animal / Q000187:drug effects; D002525:Cerebellar Cortex / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006220:Haloperidol / Q000008:administration & dosage*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects
D011954:Receptors, Dopamine; D005947:Glucose; D006220:Haloperidol; D001058:Apomorphine