Effect of environmental temperature on thermal response to chlorpromazine. II. Simulation of hypothermia in rats.
Thermal response of rats to chlorpromazine (CPZ) was determined at low (15 degrees C) and high (28 degrees C) environmental temperature. Effects of CPZ at ambient temperature of 5-33 degrees C were estimated using a drug disposition-thermoregulation model reported previously. The simulation revealed that the hypothermic effect of CPZ is greater in cold environment and is suppressed in hot environment.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D004781:Environmental Exposure; D008297:Male; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D013696:Temperature
D002746:Chlorpromazine