Dose-response relationship for chromosome aberrations induced by fecapentaene-12 in human lymphocytes.
Chromosome analyses were carried out in human lymphocytes exposed to a synthetic racemic all-trans fecapentaene-12 at 2-24 microM. A dose-dependent increase of the incidences of chromatid-type changes with distinct saturation at higher doses could be observed. The results reveal for the first time that fec-12 is a potent direct-acting mutagen in human lymphocytes.
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects; D011090:Polyenes / Q000008:administration & dosage*
D011090:Polyenes; C037357:1-(1-glycero)dodeca-1,3,5,7,9-pentaene