Diffuse hepatic uptake of technetium-99m methylene diphosphonate in a patient receiving high dose methotrexate.
A child with diffuse accumulation of [99mTc]MDP in the liver on a bone scan, at the time of study the patient had a severe, but reversible, hepatic dysfunction on the basis of methotrexate toxicity. Visualization of the liver on skeletal scintigrams can be a consequence of high-dose methotrexate therapy, as there was no other explanation for this unusual finding.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001859:Bone Neoplasms / Q000097:blood / Q000000981:diagnostic imaging* / Q000628:therapy; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000000981:diagnostic imaging*; D008727:Methotrexate / Q000009:adverse effects*; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate
D013669:Technetium Tc 99m Medronate; D008727:Methotrexate