[Experimental study of the antihypoxic properties of ibuprofen and other nonsteroidal anti-inflammatory preparations].
The antihypoxic properties of ibuprofen, diclofenac sodium, acetylsalicylic acid and phenylbutazone have been studied. Ibuprofen significantly increases survival of mice in the model of hypoxic hypoxia with hypercapnia. In addition, ibuprofen and diclofenac sodium possess antihypoxic protective activity in the models of circulatory and anoxic hypoxia in rats.
D000208:Acute Disease; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001237:Asphyxia / Q000188:drug therapy / Q000401:mortality; D004353:Drug Evaluation, Preclinical; D006935:Hypercapnia / Q000188:drug therapy / Q000401:mortality; D000860:Hypoxia / Q000188:drug therapy* / Q000401:mortality; D007052:Ibuprofen / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen
Eksperimental'noe izuchenie antigipoksicheskikh svoĭstv ibuprofena i drugikh nesteroidnykh protivovospalitel'nykh preparatov.