Effects of starvation and a high-energy diet on rat blood compartmentation of injected radioactive alanine and glucose.
The effects of starvation upon blood compartmentation and differential handling of glucose and alanine have been studied in control and cafeteria-fed rats. The injection of radioactive glucose resulted in higher specific radioactivities in intracellular glucose but lower intracellular amino acid specific radioactivities when compared with the plasma values. The cells/plasma specific radioactivity ratios increased dramatically in cafeteria rats with starvation. The injection of radioactive alanine resulted in higher cell than plasma glucose specific activities, and lower cell amino acid specific activities. All these parameters increased after a 24-hours starvation period. It is concluded that glucose synthetised by the liver is released mainly into the blood intracellular pool, being later liberated into the plasma or directly into the tissues.
D000409:Alanine / Q000378:metabolism*; D000818:Animals; D001773:Blood Cells / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002451:Cell Compartmentation; D004032:Diet; D002149:Energy Intake; D005943:Gluconeogenesis; D005947:Glucose / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism*
D002250:Carbon Radioisotopes; D005947:Glucose; D000409:Alanine