Dose and time related changes in LDH-X activity, epididymal carnitine levels and fertility, in gossypol-treated male rats.
Gossypol acetic acid could induce total infertility in male Wistar/NIN strain rats at a dose of 30 mg per kg body weight per day, for 52 days. 20 mg for 52 days and 30 mg for 38 days produced partial infertility. Highly significant correlation between parameters of infertility like reduced cauda sperm count, and implantation sites, and reduction in LDH-X activity of cauda epididymal sperm and carnitine levels in cauda epididymal fluid were observed. Testis remained unaffected.
D000818:Animals; D002331:Carnitine / Q000032:analysis*; D004822:Epididymis / Q000032:analysis / Q000187:drug effects*; D005298:Fertility / Q000187:drug effects; D006072:Gossypol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D007248:Infertility, Male / Q000139:chemically induced*; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors*; D008291:Malate Dehydrogenase / Q000032:analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000201:enzymology
D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D006072:Gossypol; C028178:gossypol acetic acid; D002331:Carnitine