The use of povidone iodine in neonatal bowel surgery.
The ostomy sites of four premature infants undergoing bowel reanastomosis were lavaged with a 10% solution of povidone iodine to reduce local bacterial contamination and the risk of anastomosis dehiscence. There was a significant decrease in serum thyroxin from 112 (+/- 11) mumol/L to 90 (+/- 33) mumol/L 24 hours following surgery (P less than .05), but no change in serum thyroid stimulating hormone (TSH). The total serum iodine rose from 1.5 (+/- 0.05) mumol/L before surgery to 61.6 (+/- 46.4) mumol/L 24 hours later and urinary iodine excretion was 60 times the preoperative value in the second 24 hours following surgery. Both the hormonal and biochemical indices returned to normal 2 weeks following surgery except for total serum iodine, which remained slightly elevated. Povidone iodine is a safe and effective antiseptic agent. However, as it may cause transient suppression of thyroid function in neonates, thyroid status should be tested in all such infants at approximately 2 weeks following repeated or widespread use.
D006801:Humans; D007081:Ileostomy; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000601:surgery*; D007455:Iodine / Q000097:blood; D011184:Postoperative Period; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000627:therapeutic use* / Q000633:toxicity; D012306:Risk; D013530:Surgical Wound Infection / Q000517:prevention & control*; D007507:Therapeutic Irrigation; D013961:Thyroid Gland / Q000187:drug effects*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
D011206:Povidone-Iodine; D013972:Thyrotropin; D007455:Iodine; D011205:Povidone; D013974:Thyroxine