title: [Modeling neurosis in the dog and a study of the effects of antidepressants].
abstract: Introduction in tests with positive (alimentary) reinforcement, of elements of uncertainty and of "collision" of motivations, and carrying out of a series of experiments on dogs under such conditions during 2-4 weeks, led to the development of heavy and stable neurotic states. They were characterized by disturbances of emotional-motivational sphere, suppression of conditioned activity, somatovegetative dysfunctions. Preparations of atypical antidepressants (emovit and new benzamine derivate) reduced neurotic manifestations. The rate of reduction depended on the spectrum of neuro-psychotropic activity and properties of pathological states in dogs.
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use; D003214:Conditioning, Classical; D003216:Conditioning, Operant; D004195:Disease Models, Animal; D004285:Dogs; D006339:Heart Rate; D009497:Neurotic Disorders / Q000188:drug therapy / Q000503:physiopathology; D012119:Respiration; D014745:Viloxazine / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D001549:Benzamides; C051916:substance 30; D014745:Viloxazine
vernacular_title: Modelirovanie nevroza u sobak i izuchenie deĭstviia antidepressantov.