Effects of glucocorticoids on the rabbit carotid body.
Weekly intramuscular injections of slow-release, depot methyl prednisolone to 15 adult Dutch rabbits did not bring about an increase in the volume of their carotid bodies. However, they caused swelling of chief cells with discrete areas of pallor in the cytoplasm. Factors responsible for these changes appear to be increased storage of catecholamines and an increased number of swollen mitochondria.
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D002344:Carotid Body / Q000187:drug effects* / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D003692:Delayed-Action Preparations; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D008933:Mitochondrial Swelling; D011239:Prednisolone / Q000633:toxicity*; D011817:Rabbits
D003692:Delayed-Action Preparations; D011239:Prednisolone