title: [Analysis of the damaging action of different doses of nicotine on the female germ cells of rat fetuses].
abstract: The conducted studies have shown the gametotropic dose-dependent nicotine effect revealed both at the light-optic and ultrastructural levels. The revealed disturbances in oocytes may be regarded as a nonspecific response of the sex cells which is observed mainly in damage of the membrane oocyte components and specific (for sex cells) structure, a synaptonemal complex. Disturbances in the somatic ovary cells manifest only with a high nicotine dose.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005333:Fetus; D005865:Gestational Age; D008540:Meiosis / Q000187:drug effects; D009538:Nicotine / Q000008:administration & dosage / Q000633:toxicity*; D009865:Oocytes / Q000187:drug effects* / Q000648:ultrastructure; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009538:Nicotine
vernacular_title: Analiz povrezhdaiushchego deĭstviia razlichnykh doz nikotina na zhenskie polovye kletki plodov krys.