PUVA-induced pigmented macules: a case involving palmoplantar skin.
A patient with palmoplantar psoriasis received a local treatment regimen of psoralens with long-wave ultraviolet A radiation (PUVA). After approximately 12 months of treatment, she developed hyperpigmented macules on her palms and soles. A biopsy showed changes consistent with PUVA-induced pigmented macules, as well as pronounced pigmentary incontinence. No cytologic atypia was noted. PUVA-induced pigmented macules should now be included in the differential diagnosis of palmoplantar hyperpigmented macules.
D005260:Female; D005533:Foot Dermatoses / Q000209:etiology / Q000473:pathology; D006229:Hand Dermatoses / Q000209:etiology / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D011701:PUVA Therapy / Q000009:adverse effects*; D010859:Pigmentation Disorders / Q000209:etiology* / Q000473:pathology; D012867:Skin / Q000473:pathology