[Pharmacokinetics of amikacin in the perilymph and blood serum. An approach to the comparative evaluation of the potential ototoxicity of aminoglycoside antibiotics].
The pharmacokinetics of amikacin in serum and perilymph was studied on guinea pigs treated with its single subcutaneous administrations in doses of 100, 200, 400 and 800 mg/kg. Proportional relation between the values of the areas under the concentration against time curves of the antibiotic in serum and perilymph was shown. It suggested that the level of the antibiotic penetration into the internal ear might be predicted by the area under the concentration against time curve of the aminoglycoside. It was demonstrated that in equitherapeutic doses when D/Deq = 1 aminoglycosides had different areas under the concentration against time curve. Thus, the area under the curve of amikacin was 2.2 times higher than that of sisomicin. It was also demonstrated that the angle coefficient characterizing the relationship between the area under the concentration against time curve in perilymph and the dose standardized with respect to the equitherapeutic value was markedly higher for amikacin than for sisomicin.
D000583:Amikacin / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007758:Ear, Inner / Q000187:drug effects*; D006168:Guinea Pigs; D007761:Labyrinthine Fluids / Q000378:metabolism*; D008722:Methods; D010498:Perilymph / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
D000583:Amikacin
Farmakonietika amikatsina v perilimfe i syvorotke krovi. Podkhod k sravnitel'noĭ otsenke potentsial'noĭ ototoksichnosti antibiotikov-aminoglikozidov.