Failure of a branched chain amino acid-enriched diet to reverse ethanol inhibition of cardiac protein synthesis in the rat.
The fractional rate of protein synthesis was determined in the hearts of rats in vivo fed on diets containing 27% of energy as ethanol or on this diet supplemented with 5% of equimolar amounts of branched chain amino acids (BCAA). Administration of ethanol significantly decreased the fractional synthetic rate of mixed cardiac proteins and this depression was not ameliorated by concomitant feeding of BCAA. These data are discussed in relation to the stimulation of cardiac protein synthesis by BCAA observed in vitro.
D000596:Amino Acids / Q000097:blood; D000597:Amino Acids, Branched-Chain / Q000494:pharmacology*; D000818:Animals; D004044:Dietary Proteins / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects; D007700:Kinetics; D009206:Myocardium / Q000378:metabolism*; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D004044:Dietary Proteins; D000431:Ethanol