[Experimental research on the action of isoptin and alkylenediamine derivatives on the aggregation capacity and the membrane-bound calcium level of thrombocytes].
It was found in experiments on rabbit platelets that isoptin and derivatives of N,N'-di(beta-phenylisopropyl)polymethylene diamines produce a dose-dependent decrease of the platelet aggregation activity. The effect correlates with a lowering of membrane-bound calcium level in platelets as shown by the fluorescent technique with the use of chlortetracycline probe. The results obtained demonstrate that the derivatives of alkylenediamines significantly suppress platelet aggregation and block membrane-bound calcium at the lower concentrations than those of isoptin.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000097:blood*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003959:Diamines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D013050:Spectrometry, Fluorescence; D014700:Verapamil / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D003959:Diamines; D000244:Adenosine Diphosphate; D014700:Verapamil; D002118:Calcium
Eksperimental'noe issledovanie deĭstviia izoptina i proizvodnykh alkilendiaminov na agregatsionnuiu sposobnost' i uroven' membranosviazannogo kal'tsiia trombotstiov.