Modification of 144Ce tissue deposition by mixed ligand complex treatment in mice.
The individual effect of desferrioxamine-B (DFOA), Na3Ca-diethylene-triaminepentaacetic acid (DTPA), DL-penicillamine (PA) and Na-salicylate (SA) has been examined as well as the effect of mixed-ligand treatment on the retention and elimination of 144Ce in mice. It was found that 144Ce could easily be mobilized by a single dose of DTPA. Mixed-ligand (MLCs) treatment did not change the deposition characteristics and translocation kinetics of 144Ce.
D000818:Animals; D001822:Body Burden; D002588:Cesium Radioisotopes / Q000008:administration & dosage / Q000378:metabolism*; D002614:Chelating Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003676:Deferoxamine / Q000494:pharmacology; D004359:Drug Therapy, Combination; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010396:Penicillamine / Q000494:pharmacology; D004369:Pentetic Acid / Q000494:pharmacology; D012459:Salicylates / Q000494:pharmacology; D020156:Salicylic Acid; D014018:Tissue Distribution
D002588:Cesium Radioisotopes; D002614:Chelating Agents; D012459:Salicylates; D004369:Pentetic Acid; D010396:Penicillamine; D003676:Deferoxamine; D020156:Salicylic Acid