Cytogenetics of bladder cancer: rearrangements of the short arm of chromosome 11.
The presence of nonrandom chromosomal defects has been reported in a number of leukemias, lymphomas, and solid tumors. Primary karyotypic changes have been described in bladder carcinoma. We report the finding of chromosomal derivative markers 11 in three cases of bladder cancer. These markers were observed in all interpretable metaphases obtained by a direct method. The involvement of the short arm of chromosome 11 in the carcinogenetic process is discussed.
D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000235:genetics*