Chemoprevention by antineoplaston A10 of benzo(a)pyrene-induced pulmonary neoplasia.
The effect of Antineoplaston A10 (AA10), an amino acid derivative isolated from human urine, has been studied on pulmonary adenoma formation resulting from intragastric administration of benzo(a)pyrene(BP) to A/HeJ mice. Two doses of BP, 3 mg each, administered two weeks apart, induced an average of 6.86 tumours within 157 days in the control animals (Tumorigenic Index 437). One per cent of AA10 (w/w) given in mouse food for one week prior to, and then continued after the administration of BP, produced a 70% reduction in the total number of tumours in the test groups.
D000236:Adenoma / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D044482:Benzeneacetamides; D001564:Benzo(a)pyrene; D001835:Body Weight / Q000187:drug effects; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D008805:Mice, Inbred A; D010880:Piperidines / Q000627:therapeutic use*; D010881:Piperidones
D000970:Antineoplastic Agents; D044482:Benzeneacetamides; D010880:Piperidines; D010881:Piperidones; C052091:antineoplaston A10; D001564:Benzo(a)pyrene