title: Interactions between sucrose, pain and isolation distress.
abstract: Two experiments were conducted that establish an opioid-based, functional-relationship between the taste of sucrose, pain threshold and distress vocalization in isolated 10-day-old albino rats. In the first experiment intraoral infusion of sucrose virtually doubled heat-withdrawal latencies. This elevation was naltrexone (0.5 mg/kg b.wt.) reversible. In the second experiment sucrose infusions caused a rapid and sustained diminution of distress vocalizations in rats totally isolated from dam and siblings. These are the first demonstrations of a causal relationship between a positive affective system and ones mediating pain and stress.
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D009271:Naltrexone / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012684:Sensory Thresholds / Q000187:drug effects; D012934:Social Isolation; D013395:Sucrose / Q000008:administration & dosage*; D013649:Taste / Q000187:drug effects / Q000502:physiology*; D014828:Vocalization, Animal / Q000187:drug effects / Q000502:physiology
chemical_list: D013395:Sucrose; D009271:Naltrexone