title: Effect of intratracheal instillation of cadmium chloride on phospholipids in alveolar wash fluid.
abstract: The effect of cadmium chloride on phospholipids in the alveolar wash fluid was investigated by instilling the chemical (2.5 micrograms Cd/0.4 ml saline per rat) into rat trachea. Two days later the phospholipid content of the wash fluid increased markedly in the cadmium-treated group to about 2.4 times that in the control (saline-treated) group. The relative amount of phosphatidylcholine and the fatty acid composition of phosphatidylcholine were not altered by the cadmium treatment, and retained a composition typical of lung surfactant. These findings suggest that cadmium induces a marked increase in surfactant phospholipids in the lung at a very low dose.
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride; D005227:Fatty Acids / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010713:Phosphatidylcholines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000378:metabolism; D011663:Pulmonary Surfactants / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D007507:Therapeutic Irrigation; D014132:Trachea
chemical_list: D005227:Fatty Acids; D010713:Phosphatidylcholines; D010743:Phospholipids; D011663:Pulmonary Surfactants; D002104:Cadmium; D019256:Cadmium Chloride