Qualitative study of chromosomal lesions induced by neutrons and neon ions in human lymphocytes at G0 phase.
Chromosomal lesions, mitotic index and cell cycle progression delay induced by neutron (protons 34 MeV on beryllium) and neon (250 MeV/i) particles are studied in human lymphocytes. The cell cycle progression is slightly decreased at a dose of 1 Gy. Mitotic indexes are significantly decreased after irradiation by the different particles, except neon in 52-h cultures. By comparison to chromosome damages caused by gamma-rays, previously published, it is found that the lesions observed here are frequently more complex: the number of breaks is higher per abnormal mitosis and higher per rearrangement on the average. This complexity is higher for neon ions than for neutron beams.
D002453:Cell Cycle / Q000187:drug effects*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D066298:In Vitro Techniques; D007399:Interphase / Q000528:radiation effects; D007477:Ions; D008940:Mitotic Index / Q000187:drug effects; D009356:Neon; D009502:Neutrons
D007477:Ions; D009356:Neon