title: [Pharmacokinetics of dipyroxime in the body of rats and dogs].
abstract: Pharmacokinetics of dipyroxime was studied following intravenous injection to noninbred albino male rats. Dipyroxime is a cholinesterase reactivating drug now widely used as an antidote in poisonings caused by organophosphorus pesticides. Dipyroxime pharmacokinetics analysis made it possible to propose a formula for approximation of the data on another animal species (dogs). The drug concentration in the dog blood plasma is in a good correlation with the predicted level.
mesh_terms: D000818:Animals; D002801:Cholinesterase Reactivators / Q000378:metabolism*; D004285:Dogs; D007273:Injections, Intramuscular; D007700:Kinetics; D008297:Male; D008433:Mathematics; D010091:Oximes / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014289:Trimedoxime / Q000378:metabolism*
chemical_list: D002801:Cholinesterase Reactivators; D010091:Oximes; D014289:Trimedoxime
vernacular_title: Farmakokinetika dipiroksima v organizme krys i sobak.