[Effect of the serum of alcoholics on the growth of primary cultures human fetal liver cells].
The study has aimed at ascertaining the role of the "serum factor" of alcoholism, the mechanism of its action on the development of liver lesions and morpho-functional properties of liver cells in alcoholics. The results obtained point to significant qualitative peculiarities of the growth of hepatocyte culture in the presence of alcoholics' serum which are expressed in suppression of liver cells and stimulation of white blood cells. The development of alcohol-related hepatic lesion (AHL) is known to be attended by mobilization of immunological mechanisms which is confirmed by the high lymphocytic activity in the considered model. Other leading signs of AHL is dystrophy of hepatocytes and proliferation of connective tissue which also manifests in a scissors-like difference in the growth of epithelium-like and fibroblast-like cells.
D000328:Adult; D000437:Alcoholism / Q000097:blood*; D002465:Cell Movement / Q000187:drug effects; D046508:Culture Techniques; D005333:Fetus; D006801:Humans; D008099:Liver / Q000187:drug effects*; D014118:Toxins, Biological / Q000097:blood* / Q000633:toxicity
D014118:Toxins, Biological
Vliianie syvorotki krovi bol'nykh alkogolizmom na rost pervichnykh kul'tur pechenochnykh kletok plodov cheloveka.