Comparison of the effects of corticosteroids and indomethacin on the response of the blood-aqueous barrier to injury.
Aqueous protein content was estimated as a measure of the integrity of the blood-aqueous barrier after paracentesis or argon laser photo-coagulation of the iris in rabbits. Corticosteroid pretreatment topically or by subconjunctival or intramuscular injection exerted only a moderate inhibitory effect on the breakdown of the blood-aqueous barrier. Instillation of 0.1% indomethacin however, strongly inhibited the response in both models. The results are indicative of the potential usefulness of topical administration of prostaglandin synthetase inhibitors in the treatment of non-infectious inflammatory diseases.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D002199:Capillary Permeability / Q000187:drug effects*; D005123:Eye / Q000098:blood supply*; D005131:Eye Injuries / Q000378:metabolism*; D005136:Eye Proteins / Q000378:metabolism; D005451:Fluorescein Angiography; D007213:Indomethacin / Q000494:pharmacology*; D007834:Lasers; D008028:Light Coagulation; D008297:Male; D011817:Rabbits
D000305:Adrenal Cortex Hormones; D005136:Eye Proteins; D007213:Indomethacin