title: Interaction between adrenergic and cholinergic nerve terminals in the urinary bladder of rabbit, cat and man.
abstract: The influence of muscarinic receptor stimulation (carbachol) and blockade (scopolamine) on the release of 3H-labelled noradrenaline from adrenergic neurons was investigated in isolated detrusor preparations from rabbit, cat and man. A significant influence on the release of 3H from adrenergic nerve terminals was found in the three species with a concentration-dependent decrease and increase induced by carbachol and scopolamine, respectively. Using the alpha 2-adrenoceptor stimulating and blocking agents clonidine and rauwolscine in rabbit and human detrusor preparations, the presence of prejunctionally located inhibitory alpha 2-adrenoceptors could also be demonstrated. The findings indicate the possibility of a functionally important interaction between cholinergic and adrenergic nerves in the urinary bladder mediated via inhibitory muscarinic receptors on adrenergic nerve terminals.
mesh_terms: D000818:Animals; D002415:Cats; D005260:Female; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010275:Parasympathetic Nervous System / Q000502:physiology*; D011817:Rabbits; D011941:Receptors, Adrenergic / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*; D001743:Urinary Bladder / Q000294:innervation*
chemical_list: D011941:Receptors, Adrenergic; D011976:Receptors, Muscarinic; D009638:Norepinephrine