title: [Induction of sarcomas by the tissue-binding substance Histoacryl-blau in the rat].
abstract: The substance Butyl-2-Cyanoacrylate (Firm Braun-Dexon) which is known by the trade name Histoacryl-blau was implanted in rats for the purpose of testing its cancer-producing properties. Of 44 animals evaluated eleven cases of sarcomas developed at the implantation site, that were apparently directly caused by the tissue binding substance. Therefore the use of this preparation in humans should be strongly restrained and employed under strict regulation especially in patients under the age of thirty.
mesh_terms: D000818:Animals; D002273:Carcinogens; D004659:Enbucrilate / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000473:pathology*; D014014:Tissue Adhesives / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D014014:Tissue Adhesives; D004659:Enbucrilate
vernacular_title: Sarkomerzeugende Wirkung des Gewebeklebers Histoacryl-blau an der Ratte.