Effect of echinomycin on DNA methylation.
Although echinomycin is reported to intercalate and to bind to DNA at CG dinucleotides, the effects of the drug on DNA methylation in vitro and in vivo are much less apparent than are the effects on DNA synthesis and cell growth.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis / Q000378:metabolism*; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000037:antagonists & inhibitors; D004448:Echinomycin / Q000494:pharmacology*; D007739:L Cells / Q000187:drug effects; D008745:Methylation; D051379:Mice; D011810:Quinoxalines / Q000494:pharmacology*
D011810:Quinoxalines; D004448:Echinomycin; D004247:DNA; D004248:DNA (Cytosine-5-)-Methyltransferases