Ultrastructural study of ochratoxicosis in quail (Coturnix coturnix japonica).
Ultrathin sections of liver and kidney from 11-week-old quail fed, from day-old, ochratoxin A (OA) (mixed in the diet at levels of 4 and 8 ppm) were examined in the electron microscope. Pathological changes in the kidneys were limited to the proximal convoluted tubules (PCT) and glomeruli. In the PCTs, abnormal mitochondria and excessive numbers of lipid droplets were the principal findings with glomeruli showing thickened basement membranes. Swollen mitochondria and variable glycogen deposition were the chief features present in the livers. It is suggested that OA is more hepatotoxic in quail than in broilers, as well as being nephrotoxic.
D000818:Animals; D003370:Coturnix; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000648:ultrastructure*; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure*; D008112:Liver Glycogen / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D009793:Ochratoxins / Q000633:toxicity*; D011784:Quail
D008112:Liver Glycogen; D009793:Ochratoxins; C025589:ochratoxin A