[Isolation and structure of the active component of the antitumor agent blastolysin].
Active principle of blastolysin, comprising ca. 40% of the total weight of Lactobacillus bulgaricus cell wall preparation, has been isolated and structurally studied by chemical and spectral methods. The substance a glycopeptide with Mr aa. 10,000, consists of two tetrasaccharide moieties connected by oligopeptide bridges; glycerophosphate, glucose, and galactose moieties are also attached to N-acetylmuramyl residue of the peptidoglucan core. Tetrasaccharide-containing muramylpeptides were shown to be responsible for the antitumour activity.
D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D002240:Carbohydrate Sequence; D002851:Chromatography, High Pressure Liquid; D006020:Glycopeptides / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D006868:Hydrolysis; D013058:Mass Spectrometry; D051379:Mice; D012510:Sarcoma 180 / Q000473:pathology
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D006020:Glycopeptides; C025182:blastolysin
Vydelenie i struktura aktivnogo komponenta protivoopukholevogo preparata blastolizina.