Enhanced integumental and ocular amelanosis following the termination of cyclosporine administration.
The Smyth delayed amelanotic line of chickens display symptoms commonly associated with human vitiligo. Administration of the immunosuppressive compound, cyclosporine, significantly delayed the mean age of onset and incidence of integumental pigment losses in this mutant line of vitiliginous chickens. Associated ocular pathology was also less severe in treated chicks. Termination of cyclosporine administration resulted in enhanced integumental and choroidal amelanosis, choroidal inflammation, and chorioretinal damage beyond that observed in nontreated controls. These results suggest that withdrawal of cyclosporine in treatment of this spontaneous autoimmune disease may exacerbate associated symptoms.
D000818:Animals; D002645:Chickens; D003524:Cyclosporins / Q000008:administration & dosage / Q000009:adverse effects*; D005128:Eye Diseases / Q000378:metabolism* / Q000473:pathology; D010859:Pigmentation Disorders / Q000378:metabolism* / Q000517:prevention & control; D012867:Skin / Q000378:metabolism*; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D014820:Vitiligo / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
D003524:Cyclosporins