[Effect of a single dose of Pharmachim cimetidine on the pH of the stomach].
The effect of Cimetidine (Pharmachim), tablets of 200 mg on pH of the stomach was studied in 30 patients with active duodenal ulcer via two-electrode pH-metric probe. The drug effect could be seen from the summed up pH-gram of the patients. pH increase (p less than 0.001) began by 45 min, reaching the maximum by 135 min and lasting for 3.5 hours on the average, the pH maintained over 3.00 in the corpus and over 5.00 in the antrum for 2 h and 45 min. That effect showed a difference depending on the values of the basal pH being significantly stronger in the patients with basal normacidity (8 subjects) and compensated hyperacidity (II subjects) as compared with those with decompensated hyperacidity (II subjects). In the latter, the tested dose was not sufficiently effective--pH in the corpus was maintained over 3.00 only for 1/2 h, and in the antrum over 5.00--I h. In the other 2/3 of the patients, the single dose of Cimetidine (Pharmachim) of 200 mg proved to be sufficient for and effective control of the gastric acid secretion in the course of 3.5 hours.
D002927:Cimetidine / Q000494:pharmacology* / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000378:metabolism; D005745:Gastric Acidity Determination; D006801:Humans
D002927:Cimetidine
Efekt na ednokratna doza simetidin "Farmakhim" vurkhu pH na stomakha.