Visualization of adenosine A1 receptors in the human and the guinea-pig kidney.
Adenosine A1 receptors were localized in sections of human and guinea-pig kidney with quantitative receptor autoradiography and [3H]cyclohexyladenosine [( 3H]CHA) used as ligand. The binding sites had the characteristics of an A1 receptor. In the human kidney a high density of receptor sites was measured over the glomeruli. In the guinea-pig kidney the receptor sites were localized in the inner and outer medulla although a low density of binding was also seen over the glomeruli. The functional significance of the findings is discussed.
D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D000368:Aged; D000369:Aged, 80 and over; D001345:Autoradiography; D006801:Humans; D007668:Kidney / Q000033:anatomy & histology / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D008297:Male; D011983:Receptors, Purinergic / Q000378:metabolism*; D013045:Species Specificity
D011983:Receptors, Purinergic; C027513:N(6)-cyclohexyladenosine; D000241:Adenosine