Septicemia due to DF-2. Cause of a false-positive cryptococcal latex agglutination result.
A previously healthy 26-year-old man presented with fever, headache, skin rash, and thrombocytopenia. Cultures of blood and cerebrospinal fluid yielded a fastidious gram-negative bacillus, identified as DF-2. A unique feature of this case was the presence of a false-positive latex agglutination result for cryptococcal antigen in the cerebrospinal fluid in the absence of pleocytosis. Additional laboratory studies, which included indirect immunofluorescence and sodium dodecyl sulfate-polyacrylamide gel electrophoresis, however, failed to reveal common antigenic surface components between these organisms.
D000328:Adult; D000942:Antigens, Bacterial / Q000032:analysis; D000946:Antigens, Fungal / Q000134:cerebrospinal fluid*; D002701:Chloramphenicol / Q000627:therapeutic use; D003454:Cryptococcus / Q000276:immunology*; D004359:Drug Therapy, Combination; D005189:False Positive Reactions; D006090:Gram-Negative Bacteria / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007841:Latex Fixation Tests; D008297:Male; D010406:Penicillins / Q000627:therapeutic use; D018805:Sepsis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology
D000942:Antigens, Bacterial; D000946:Antigens, Fungal; D010406:Penicillins; D002701:Chloramphenicol