title: Developmental-stage-specific expression of the hsp70 gene family during differentiation of the mammalian male germ line.
abstract: Mouse somatic tissues contain low levels of transcripts homologous to the heat shock-inducible and cognate members of the heat shock protein 70 (hsp70) gene family. An abundant, unique sized hsp70 mRNA of 2.7 kilobases (kb) is present in testes in the absence of exogenous stress. Its expression is restricted to germ cells and is developmentally regulated. The 2.7-kb transcript first appears during the haploid phase of spermatogenesis and is stable throughout the morphogenic stages of spermiogenesis. A 2.7-kb hsp70 mRNA is present in rat and human testes. These observations suggest that a member of the hsp70 gene family plays a role in the development of the mammalian male germ cell lineage.
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D007739:L Cells; D008297:Male; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D013087:Spermatids / Q000502:physiology*; D013091:Spermatogenesis; D013737:Testis / Q000166:cytology / Q000502:physiology*
chemical_list: D006360:Heat-Shock Proteins; D012333:RNA, Messenger