[Preparation of a cytostatic-containing bone cement].
Local application of cytostatic during therapy of tumors in bones is desirable. In these cases the drugs had to be incorporated in bone glue. Liberation, stability and side-effects have been estimated using methotrexate and doxorubicin (Adriblastin) in vitro. The liberation were determined in combination with auxiliary substances and even solidity of the bone glue was maintained.
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000032:analysis; D001843:Bone Cements; D004317:Doxorubicin / Q000008:administration & dosage; D004355:Drug Stability; D005079:Excipients; D008727:Methotrexate / Q000008:administration & dosage; D011312:Pressure; D012995:Solubility
D000970:Antineoplastic Agents; D001843:Bone Cements; D005079:Excipients; D004317:Doxorubicin; D008727:Methotrexate
Zur Herstellung eines cytostaticahaltigen Knochenzementes.