title: [Local cholinergic agonists and paradoxal systemic reactions].
abstract: In relation to two cases of paradoxal systemic reaction following instillation of pilocarpine and acetylcholine, we discuss risk factors which promote these reactions and propose an etio-pathogenical hypothesis. Furthermore, as one of the patients presented also a hypersensitivity to epinephrine; he associated two manifestations which, to our knowledge, have not yet been reported in the same patient.
mesh_terms: D000109:Acetylcholine / Q000009:adverse effects*; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D004342:Drug Hypersensitivity / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D010277:Parasympathomimetics / Q000009:adverse effects / Q000494:pharmacology; D010656:Phenylephrine / Q000009:adverse effects; D010862:Pilocarpine / Q000009:adverse effects*
chemical_list: D010277:Parasympathomimetics; D010862:Pilocarpine; D010656:Phenylephrine; D000109:Acetylcholine
vernacular_title: Agonistes cholinergiques locaux et réactions systémiques paradoxales.