title: Multistage model interpretation of additive and multiplicative carcinogenic effects.
abstract: Under the assumption of multistage carcinogenesis, a multiplicative carcinogenic effect would be produced by the action of different carcinogens in a mixture on different stages of the carcinogenic process. An additive effect would be produced by the effect of different carcinogens on the same stage. A mathematical argument for these hypotheses is presented here.
mesh_terms: D002273:Carcinogens; D004347:Drug Interactions; D006801:Humans; D008962:Models, Theoretical; D009369:Neoplasms / Q000139:chemically induced; D012306:Risk
chemical_list: D002273:Carcinogens