On an Mg2+-dependent interaction of actin with glyceraldehyde-phosphate dehydrogenase. The fundamental role of KCl in the organization of F-actin.
In the presence of Mg2+, the formation of actin filaments is hindered by glyceraldehyde-3-phosphate dehydrogenase. This effect, which increases with the square of Mg2+ concentration, is counteracted by 0.15 M KCl. Thus KCl, at concentrations found in the intracellular compartment, appears to be strictly required for the correct formation of actin filaments in all tissues in which the glyceraldehyde-phosphate dehydrogenase concentration is high.
D000199:Actins; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D008274:Magnesium / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology*
D000199:Actins; D011189:Potassium Chloride; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D008274:Magnesium