[Effect of central cholinolytics on the process of lipid peroxidation].
The effect of central M- and N-cholinolytics on Fe++-ascorbate-dependent lipid peroxidation (LP) in the rat brain homogenate was studied in vitro. Central N-cholinolytics were shown to inhibit LP. Pediphen was the most active drug. Central M-cholinolytics were not active. Pediphen and an antioxidant ionol equally decreased LP in the rat brain after carbon tetrachloride intoxication (3 ml/kg). Ionol and pediphen had N- and not M-cholinolytic effect. It is suggested that membrane stabilization by N-cholinolytics is dependent on the antioxidant effect of the drugs. These data show an important role of LP in the function of cholinergic system.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000096:biosynthesis*; D010276:Parasympatholytics / Q000494:pharmacology*; D051381:Rats
D000975:Antioxidants; D008054:Lipid Peroxides; D010276:Parasympatholytics
Vliianie tsentral'nykh kholinolitikov na protsess perekisnogo okisleniia lipidov.