A new case of Hb Little Rock [beta 143(H21)His----Gln], a high affinity variant. Study during pregnancy.
A new case of Hb Little Rock [beta 143(H21)His----Gln] is described. This high affinity variant (P50 = 15 mm Hg in whole cells) has a nearly normal cooperativity. The abnormal beta chain is readily detectable using urea-Triton X-100 electrophoresis. The altered beta T-14 peptide was separated by high performance liquid chromatography. The proposita was followed during a pregnancy. Oxygen unloading was reduced, but normal oxygen loading was maintained in the fetus. There were neither placental abnormalities, nor intrauterine growth retardation.
D000328:Adult; D000596:Amino Acids / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D010100:Oxygen / Q000378:metabolism; D011247:Pregnancy / Q000097:blood*
D000596:Amino Acids; D006455:Hemoglobins, Abnormal; C029233:hemoglobin Little Rock; D010100:Oxygen