Tolerability of a new vitamin K1 preparation for parenteral administration to adults: one case of anaphylactoid reaction.
The efficacy and tolerability of a conventional vitamin K1 preparation containing polyoxyethylated castor oil as solubilizer were compared with those of a new compound containing mixed micelles as solubilizer in 30 patients. A statistically significant increase in the thrombotest was detected after treatment in both groups. No hematological or chemical toxicity was observed during the observation period. One patient had an anaphylactoid reaction after intravenous injection of the mixed micelles preparation. Intradermal testing yielded positive results. The authors conclude that intravenous administration of vitamin K preparations should be reserved for acute emergencies.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000707:Anaphylaxis / Q000139:chemically induced*; D001780:Blood Coagulation Tests; D005079:Excipients; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010837:Vitamin K 1 / Q000008:administration & dosage / Q000009:adverse effects*; D014813:Vitamin K Deficiency / Q000188:drug therapy*
D005079:Excipients; D010837:Vitamin K 1