Parvodicin, a novel glycopeptide from a new species, Actinomadura parvosata: discovery, taxonomy, activity and structure elucidation.
An extensive taxonomic investigation identified strain SK&F-AAJ-271 as a new species, designated Actinomadura parvosata. Fermentations of this organism produce a complex of acidic, lipophilic glycopeptide antibiotics, the parvodicins. Structures for seven of the isolated components were derived from a combination of mass spectral, high-field NMR and chemical techniques. The O-acetyl functionality present in two of the isolated components is a structural feature unique among the known members of this class of antibiotics. The parvodicins are active in vitro against a range of Gram-positive bacteria. The most active parvodicin, C1, produces high serum levels in vivo and has the potential for a long duration of action.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000302:isolation & purification*; D005285:Fermentation; D006020:Glycopeptides / Q000097:blood / Q000302:isolation & purification; D006207:Half-Life; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009618:Nocardiaceae / Q000032:analysis*; D012310:Ristocetin / Q000031:analogs & derivatives*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D012310:Ristocetin; C053532:parvodicin A