title: Peptic ulceration in leukaemia.
abstract: Two children with leukaemia are described who successfully underwent oversewing of perforated duodenal ulcers which probably were secondary to immunosuppression and steroid therapy. This is only the second report of ulceration in childhood leukaemia. Stress ulceration in children responds favourably to conservative surgery and removal of the insult. Ulcer prophylaxis with antacids or Cimetidine should be initiated in patients being subjected to combined immunosuppression and high-dose steroids, particularly during bone marrow transplantation.
mesh_terms: D000293:Adolescent; D002648:Child; D004381:Duodenal Ulcer / Q000150:complications*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007938:Leukemia / Q000150:complications* / Q000628:therapy; D008297:Male; D010439:Peptic Ulcer Perforation / Q000209:etiology*; D011239:Prednisolone / Q000009:adverse effects
chemical_list: D007166:Immunosuppressive Agents; D011239:Prednisolone