Allergic contact dermatitis from proprietary topical analgesic sprays containing 3-(aminomethyl)-pyridyl salicylate.
Eleven cases of allergic contact dermatitis following the use of proprietary topical analgesic sprays (Algiospray and Pangesic) are described. Patch testing revealed that the adverse reactions were attributable to 3-(aminomethyl)-pyridine, which is present in these products as an ion pair with salicylic acid. The similarity between the two products investigated is not immediately apparent from the chemical nomenclature used by the manufacturers to describe the ingredients of their sprays.
D000287:Administration, Topical; D000328:Adult; D000336:Aerosols; D000368:Aged; D000631:Aminopyridines / Q000009:adverse effects*; D000700:Analgesics / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D012459:Salicylates / Q000009:adverse effects*
D000336:Aerosols; D000631:Aminopyridines; D000700:Analgesics; D012459:Salicylates; C053225:3-(methylamino)pyridyl salicylate; C053224:3-(aminomethyl)pyridyl salicylate