title: Vitamin E kinetics in sheep.
abstract: 1. Kinetics of physiological doses of D-alpha-[5-Me-3H]tocopherol (200 microCi) administered to twenty-four sheep were studied using one of four routes: intravenous, oral (capsules), intraruminal and intramuscular. 2. Blood samples were withdrawn from the jugular vein periodically for 96 h after the intravenous and oral administrations, for 168 h after the intraruminal administration and for 216 h after the intramuscular administration. 3. The study indicated that the biological availability of alpha-tocopherol followed the order intravenous greater than intramuscular greater than oral greater than intraruminal. 4. The rate of elimination was in the order intravenous greater than oral greater than intraruminal approximately intramuscular. 5. The intravenous route was fitted with a three-compartment model, whereas the other routes exhibited a good fit for either a one- or two-compartment model.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D012417:Rumen; D012756:Sheep / Q000378:metabolism*; D014810:Vitamin E / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D014810:Vitamin E