Studies on new antibiotics SF2415. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
A new species of Streptomyces is described for which the name Streptomyces aculeolatus is proposed. The organism produces new antibiotics SF2415A1, A2, A3, B1, B2 and B3 active against Gram-positive bacteria. Empirical molecular formulae of the antibiotics SF2415A1, A2, A3, B1, B2 and B3 were determined to be C26H31N2O5Cl, C26H30N2O5, C26H30N2O5Cl2, C26H33O5Cl, C26H32O5 and C26H32O5Cl2, respectively.
D000818:Animals; D000900:Anti-Bacterial Agents; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007700:Kinetics; D007928:Lethal Dose 50; D013058:Mass Spectrometry; D051379:Mice; D009285:Naphthoquinones / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D013053:Spectrophotometry; D013302:Streptomyces / Q000145:classification / Q000302:isolation & purification / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D009285:Naphthoquinones