Detection of microalbuminuria in diabetic patients using a simple latex agglutination test.
The adaptation of an immunoturbidimetric assay to quantitatively measure urinary albumin is described and this was used to evaluate a commercial latex agglutination slide test, Albuscreen, with a sensitivity of 25 mg/l. Excellent agreement was observed between the two methods, and in clinical studies an acceptable classification of patients was made using Albuscreen, an albumin: creatinine ratio of less than or equal to 2.5 being used to indicate possible microalbuminuria. A small number of false negative and false positive results occurred in some dilute and concentrated urine samples, respectively.
D000419:Albuminuria / Q000175:diagnosis / Q000652:urine*; D003920:Diabetes Mellitus / Q000652:urine*; D003928:Diabetic Nephropathies / Q000175:diagnosis*; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D007841:Latex Fixation Tests; D009391:Nephelometry and Turbidimetry; D013048:Specimen Handling