Direct assessment of brown adipose tissue as a site of systemic tri-iodothyronine production in the rat.
Tri-iodothyronine (T3)production by interscapular brown fat was studied by measurements of arterio-venous differences and blood flow across the tissue in rats exposed to the following situations: controls, acute cold, chronic cold and starvation. Results demonstrate that brown adipose tissue is a source of systemic T3 in the rat and that the T3 release is modulated according to the physiological situation of the animal: increased in cold exposure and inhibited in starvation.
D002001:Adipose Tissue, Brown / Q000098:blood supply / Q000201:enzymology / Q000378:metabolism*; D000818:Animals; D003080:Cold Temperature; D007453:Iodide Peroxidase / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism; D014284:Triiodothyronine / Q000096:biosynthesis*
D014284:Triiodothyronine; D007453:Iodide Peroxidase