Morphological development of the mouse gonad in tda-1 XY sex reversal.
tda-1 XY sex reversal occurs when the Y chromosome of at least some populations of wild Mus musculus domesticus is placed on the C57BL/6J genomic background. Gross anatomical observations have previously revealed morphological similarities among fetal ovotestes of tda-1 and Tas-inherited XY sex reversals and BALB/cWt mosaic hermaphrodites. We studied the histology of tda-1 XY sex-reversed gonads, ranging in age from day 14 of gestation to adult. The obtained data revealed additional similarities with ovotestes of BALB/cWt mosaic hermaphrodites as well as with ovotestes of hermaphrodites found in XXSxr and XX/XY chimeras. It is proposed that ovotestes occurring in these various hermaphroditic conditions may be formed through a common pathway.
D000375:Aging; D000818:Animals; D003433:Crosses, Genetic; D012734:Disorders of Sex Development; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010053:Ovary / Q000166:cytology / Q000196:embryology / Q000254:growth & development*; D010641:Phenotype; D011247:Pregnancy; D013737:Testis / Q000166:cytology / Q000196:embryology / Q000254:growth & development*; D014960:X Chromosome; D014998:Y Chromosome