title: Comparative choleretic and hepatoprotective properties of young sprouts and total plant extracts of Rosmarinus officinalis in rats.
abstract: Lyophilised ethanol and aqueous extracts of Rosmarinus officinalis young sprouts and total plant have been evaluated for choleretic and hepatoprotective activities in the rat. R. officinalis ethanol extracts prepared from young sprouts show a significant dose-related choleretic activity and are more active than the total plant extract. Aqueous extracts of young sprouts show a significant hepatoprotective effect on plasma GPT levels when given as pretreatment before carbon tetrachloride intoxication while the whole plant extract was inactive. Both sprouts and whole plant aqueous extracts were ineffective when given after carbon tetrachloride administration.
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001646:Bile / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D002756:Cholagogues and Choleretics; D004305:Dose-Response Relationship, Drug; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012838:Silymarin / Q000494:pharmacology
chemical_list: D002756:Cholagogues and Choleretics; D010936:Plant Extracts; D012838:Silymarin; D000410:Alanine Transaminase