Effects of sexual steroid hormones treatment on Ca2+ sensitivity of chemically skinned uterine muscle fibers from ovariectomized rats.
We considered the possible relationship between the serum levels of progesterone and estradiol-17 beta, which were controlled to that of several stages in normal pregnant rats, and the Ca2+ sensitivity, defined as the pCa required for half maximum activation of force production, of chemically skinned uterine muscle fibers from ovariectomized rats. The Ca2+ sensitivity was negligibly influenced by the levels of these hormones.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D004958:Estradiol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D009215:Myometrium / Q000502:physiology*; D010052:Ovariectomy; D011247:Pregnancy; D011270:Pregnancy, Animal; D011374:Progesterone / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects*
D011374:Progesterone; D004958:Estradiol; D002118:Calcium