title: [Total LDH activity and isoenzyme spectrum in experimental Cysticercus ovis infestation of lambs and kids].
abstract: Investigations were carried out with 10 lambs and 4 kids at the age of two months, divided into three groups. The test animals of the first group (5 lambs) were infected with 7,000 T. ovis eggs each, and those of the second group (5 lambs) and those of the third group (4 kids)--with 20,000 T. ovis eggs each. It was found that following infection the total activity of lactate dehydrogenase (LDH) rose, reaching its peak values on the 12th and 15th day. On the 12th day the strongly enhanced enzyme activity was due to the rise of LDH1, while on the 15th day the enhancement was associated with the rise of LDH5 that was characteristic of the skeletal muscles. In the period of forming the connective tissue capsule around the cysticerci the changes in the total activity and the isoenzyme spectrum were more slightly manifested. After the 30th day both the activity and the spectrum of LDH steadily came back to normal. With a C. ovis infection there was also a strongly expressed response on the part of hemopoietic organs, with a pronounced LDH3 activity.
mesh_terms: D000818:Animals; D003551:Cysticercosis / Q000201:enzymology / Q000662:veterinary*; D004591:Electrophoresis, Polyacrylamide Gel; D006041:Goats / Q000097:blood*; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D012756:Sheep; D012757:Sheep Diseases / Q000201:enzymology*; D013997:Time Factors
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
vernacular_title: Obshta aktivnost i izoenzimen spektŭr na LDKh pri eksperimentalno invazirani s Cysticercus ovis agneta i kozleta.