Interaction between glucose diet and ethanol on rat liver microsomal induction and liver plasma membrane damage in chronic hexachlorobenzene intoxication.
Male Wistar rats fed for 60 days a glucose diet containing 17.5 mmol hexachlorobenzene/kg show a less pronounced increase in serum parameters and microsomal cytochrome P-450 concentration and a lower decrease in liver plasma membrane 5'-nucleotidase, K+, Na+- and Mg++-adenosine triphosphatase activities than the controls fed standard diet + hexachlorobenzene. Addition of 10% ethanol to the drinking water eliminates the "glucose effect". The glucose diet and ethanol exert contrasting effects on microsomal enzyme induction and liver plasma membrane damage in hexachlorobenzene intoxication.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D002722:Chlorobenzenes / Q000633:toxicity*; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D006581:Hexachlorobenzene / Q000633:toxicity*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D002722:Chlorobenzenes; D004040:Dietary Carbohydrates; D000431:Ethanol; D006581:Hexachlorobenzene; D005947:Glucose