Renal effects of tolazoline in newborn and adult rabbits.
The effect of tolazoline on renal function was studied in normoxemic newborn and adult anesthetized rabbits. Adult animals responded to 1 mg/kg + 1 mg/kg/h of tolazoline with a marked increase in systemic blood pressure and renal vascular resistance along with a decrease in urine flow rate, glomerular filtration rate and renal blood flow. Blood pressure also increased in newborn rabbits given a similar dose of tolazoline, but the same renal parameters remained remarkably stable. The renal effect of tolazoline in adult animals probably corresponds to a partial alpha-agonist action of tolazoline. It is suggested that a relative adrenergic renal immaturity present in the newborn rabbit protects him from the deleterious effect of tolazoline.
D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure / Q000187:drug effects; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D051381:Rats; D012079:Renal Circulation / Q000187:drug effects; D014043:Tolazoline / Q000494:pharmacology*
D014043:Tolazoline