title: The effect of cyclosporine in chlamydial eye infection.
abstract: The effect of cyclosporine (CsA) treatment in both primary and secondary Chlamydia trachomatis ocular infection in cynomolgus monkeys was studied. Following primary infection, CsA-treated animals developed severe clinical symptoms which persisted for up to 12 weeks compared to control animals which developed less severe inflammation lasting only 4 to 6 weeks. CsA treatment had no effect on the clinical course of a second ocular infection. Antigen-specific antibodies developed normally in the serum and tears of all animals, but the titer of IgM in serum and secreted IgA in tears of CsA-treated animals was significantly lower than control animals. Chlamydia-specific cell-mediated immunity, as determined by in vitro lymphoproliferation assays of peripheral blood, did not develop in either group of animals.
mesh_terms: D000818:Animals; D003524:Cyclosporins / Q000627:therapeutic use*; D007111:Immunity, Cellular; D007114:Immunization; D007136:Immunoglobulins / Q000145:classification / Q000378:metabolism; D008252:Macaca fascicularis; D013666:Tears / Q000378:metabolism; D014141:Trachoma / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism
chemical_list: D003524:Cyclosporins; D007136:Immunoglobulins