title: Efficacy in turkeys of spray vaccination with a temperature-sensitive mutant of Bordetella avium (Art Vax).
abstract: Broad-breasted white turkeys were vaccinated with a temperature-sensitive mutant of Bordetella avium (Art Vax) at 2 and 15 days of age and challenged at 22 days of age by contact with infected birds. Necropsy was performed at 35 days of age. Two vaccination protocols (eyedrop/oral and spray cabinet/spray bottle) and two challenge isolates (Arkansas 105 and North Carolina [NC] isolates) were used. Neither the spray nor the eyedrop/oral methods of vaccination prevented infection of the anterior trachea with either of the virulent challenge strains. The spray and eyedrop/oral methods of vaccination were equally effective in reducing the severity of gross lesions in the trachea. The vaccine reduced the severity of gross lesions in the tracheas of turkeys challenged with the NC isolate to a level approximately equal to that observed in unchallenged vaccinated controls, but the vaccine only moderately reduced the severity of lesions in birds challenged with the 105 isolate.
mesh_terms: D000284:Administration, Oral; D000336:Aerosols; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D001884:Bordetella / Q000235:genetics / Q000276:immunology*; D001885:Bordetella Infections / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D009154:Mutation; D009883:Ophthalmic Solutions; D011201:Poultry Diseases / Q000517:prevention & control*; D013696:Temperature; D014422:Turkeys; D014611:Vaccination / Q000662:veterinary
chemical_list: D000336:Aerosols; D001428:Bacterial Vaccines; D009883:Ophthalmic Solutions