title: [Radionuclide evaluation of liver function in breast cancer based on mathematical modelling].
abstract: The paper is concerned with a clinico-diagnostic follow-up of 78 breast cancer patients: stages IIA (8), IIB (12), IIIA (39), IIIB (39), IIIC (10) and IV (9). The results of radionuclide investigations were interpreted using mathematical simulation of 131-I-rose bengal permitting separate assessment of the phases of absorption, excretion and passage via the biliary tracts. Indices of hepatocytic absorptive capacity were as follows: normal function in 41%, accelerated one in 48% and retarded in 11% of the patients. Excretory function was normal in 64%, accelerated in 26% and retarded in 10% of the patients. The indicator return from hepatocytes into the blood was normal in 47%, accelerated in 35% and retarded in 18% of the patients. Kinetics of the agent via the biliary tracts was normal in 80%, accelerated in 35% and retarded in 5% of the patients. Generalized assessment of the liver status has shown that in breast cancer patients normal function is noted in 12%, intensive function in 63% and suppressed function in 25%. A stage of disease has been also shown to influence the liver status; liver function deteriorates with disease spreading.
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008099:Liver / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008111:Liver Function Tests / Q000379:methods; D008433:Mathematics; D008954:Models, Biological; D009367:Neoplasm Staging; D011877:Radionuclide Imaging; D012395:Rose Bengal
chemical_list: D007457:Iodine Radioisotopes; D012395:Rose Bengal
vernacular_title: Radionuklidnaia otsenka funktsii pecheni pri rake molochnoĭ zhelezy na osnove matematicheskogo modelirovaniia.