[Mechanisms of retinal damage in chloroquine retinopathy].
The paper presents the results of comparative electron microscopic, electrophysiological and biochemical studies of chloroquine effect on lipid peroxidation (LPO) both in vitro and in vivo (rabbits and rats). It has been shown that the progress of chloroquine retinopathy was not accompanied by the increment of the initial LPO level, and the use of ionol antioxidant did not protect the retina from the adverse effect of chloroquine. Besides, chloroquine was shown to suppress LPO in vitro. The results obtained substantiate the idea that LPO is not the primary mechanism in chloroquine retinopathy.
D000818:Animals; D002738:Chloroquine / Q000506:poisoning*; D008054:Lipid Peroxides / Q000096:biosynthesis; D011817:Rabbits; D051381:Rats; D012160:Retina / Q000187:drug effects* / Q000378:metabolism; D012164:Retinal Diseases / Q000139:chemically induced* / Q000378:metabolism
D008054:Lipid Peroxides; D002738:Chloroquine
Mekhanizmy povrezhdeniia setchatki pri khlorokhinovoĭ retinopatii.