Sister chromatid exchange and chromosomal breakage in pentachlorophenol (PCP) exposed workers.
A cytogenetic study was performed on 20 healthy workers exposed to pentachlorophenol (PCP) in concentrations ranging from 1.2 to 180 micrograms/m3 (Maximum Concentration at the workplace is 500 micrograms/m3) for 3 to 34 years. PCP was determined in the blood plasma of all probands, yielding concentrations between 23 and 775 micrograms/l (Biological Tolerance Value is 1000 micrograms/l). In vitro PCP up to 90 mg/l was added to phytohaemagglutinin stimulated lymphocytes of normal healthy donors without any effect on sister chromatid exchange (SCE) or chromosomal aberrations (CA), whereas a slowdown of cell proliferation could be detected in the presence of 60 mg PCP/l. In vivo we neither observed a relation between PCP concentrations and the number of SCE nor an increase of CA.
D000328:Adult; D002455:Cell Division / Q000187:drug effects; D002733:Chlorophenols / Q000009:adverse effects*; D002869:Chromosome Aberrations; D004781:Environmental Exposure; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008875:Middle Aged; D010416:Pentachlorophenol / Q000009:adverse effects* / Q000097:blood / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects
D002733:Chlorophenols; D010416:Pentachlorophenol