Human leukocyte antigen associated with endometrial carcinoma with a new classification of endometrial carcinoma based on its etiology.
To elucidate the relationship between endometrial carcinoma and the constitution, HLA antigen typing (A-locus, 13; B-locus, 20; C-locus, 6; DR-locus, 9) was investigated in 74 patients with endometrial carcinoma. A significant increase in two HLA antigens, Cw7 and DRw8, was demonstrated, but there was no intimate correlation between Cw7 or DRw8 and the three complications commonly associated with endometrial carcinoma--diabetes mellitus, obesity, and hypertensive disease. On the basis of these results, a new classification of endometrial carcinoma was proposed as follows: type A is positive Cw7 or DRw8 group; type B is negative for Cw7 and DRw8 and positive for the complications mentioned; type C is negative for Cw7 and DRw8, negative for the complications mentioned, and positive for DR 5; type D is a non-A, non-B, and non-C type.
D000328:Adult; D000368:Aged; D048909:Diabetes Complications; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015236:HLA-C Antigens; D006684:HLA-DR Antigens / Q000032:analysis; D059810:HLA-DR Serological Subtypes; D006801:Humans; D006973:Hypertension / Q000150:complications; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D014594:Uterine Neoplasms / Q000145:classification / Q000209:etiology / Q000276:immunology*
D006680:HLA Antigens; D015236:HLA-C Antigens; C040178:HLA-C*70 antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C041559:HLA-DR8 antigen