[Effect of oxaloacetic acid on hydrogen-calcium metabolism in mitochondria].
It has been shown by using o-phthalic acid--a concurrent inhibitor of the transport of oxalacetic acid in mitochondria that the effect of the latter on the mechanism of 2H+/Ca2+-metabolism is realized at the inner side of the inner mitochondrial membrane. Oxalacetic acid was shown to induce not only the release of Ca2+ ions but also those of strontium and manganese accumulated in the mitochondria (100-150 nmol/mg of protein). Mechanism of the effect of oxalacetic acid on permeability of the mitochondria membranes are discussed.
D000818:Animals; D001667:Binding, Competitive; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D006859:Hydrogen / Q000378:metabolism*; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000378:metabolism; D007700:Kinetics; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010071:Oxaloacetates / Q000378:metabolism / Q000494:pharmacology*; D010539:Permeability; D010795:Phthalic Acids / Q000494:pharmacology; D051381:Rats
D010071:Oxaloacetates; D010795:Phthalic Acids; C032279:phthalic acid; D006859:Hydrogen; D002118:Calcium
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