A new diuretic that does not reduce renal handling of uric acid in rats, S-8666.
The uric acid-retaining effects of diuretics were studied using sodium-restricted spontaneously hypertensive rats. Test agents were administered orally once a day for two weeks. Diuretic thiazides such as trichlormethiazide and hydrochlorothiazide and loop diuretics such as furosemide and indacrinone clearly reduced the renal function for uric acid excretion in treatment which produced major effects such as diuresis, saluresis and hypotension. However, a new diuretic with uricosuric activity, S-8666, developed in our laboratories, had no effect on the renal handling of uric acid at doses which showed major effects similar to those of other diuretics. The results should aid the understanding of the utility of S-8666 as a new diuretic antihypertensive which does not cause hyperuricemia during therapy.
D000818:Animals; D000959:Antihypertensive Agents; D004232:Diuretics / Q000009:adverse effects / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology; D006852:Hydrochlorothiazide / Q000494:pharmacology; D007189:Indans / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000652:urine; D051381:Rats; D011918:Rats, Inbred SHR; D013449:Sulfonamides / Q000494:pharmacology*; D014527:Uric Acid / Q000378:metabolism*
D000959:Antihypertensive Agents; D004232:Diuretics; D007189:Indans; D013449:Sulfonamides; D006852:Hydrochlorothiazide; C052960:S 8666; D014527:Uric Acid; D005665:Furosemide; C013352:indacrinone; D011188:Potassium