Secondary metabolites by chemical screening. I. Calcium 3-hydroxyquinoline-2-carboxylate from a Streptomyces.
Streptomyces griseoflavus subsp. (Gö 3592) was investigated by chemical screening methods. The mycelium contained gilvocarcin V (1). The culture filtrate contained the calcium salt of 3-hydroxyquinoline-2-carboxylic acid (2) confirmed by spectroscopic methods and by a 5-step partial synthesis of the free acid (3).
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003374:Coumarins; D006027:Glycosides / Q000378:metabolism; D006912:Hydroxyquinolines / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013053:Spectrophotometry; D013302:Streptomyces / Q000378:metabolism*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003374:Coumarins; D006027:Glycosides; D006912:Hydroxyquinolines; C053530:3-hydroxyquinoline-2-carboxylic acid; C031781:gilvocarcin V