Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats.
Lesion formation due to oral administration of absolute ethanol could be prevented by parenteral pretreatment with antiperoxidative drugs such as butylated hydroxytoluene (BHT), quercetin and quinacrine. Also effective were allopurinol and oxypurinol, inhibitors of xanthine oxidase, but not superoxide dismutase (SOD) and hydroxyl radical scavengers, such as sodium benzoate and dimethyl sulfoxide (DMSO). BHT, quercetin, quinacrine and sulfhydryl compounds such as reduced glutathione and cysteamine which offer gastroprotection in vivo against ethanol inhibited lipid peroxidation induced in vitro by ferrous ion in porcine gastric mucosal homogenate, but SOD, sodium benzoate, DMSO, allopurinol and oxypurinol did not. These results suggest the possibility that an active species, probably derived from free iron mobilized by the xanthine oxidase system, other than oxygen radicals such as hydroxyl radicals, contributes to lipid peroxidation and lesion formation in the gastric mucosa after absolute ethanol administration.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D000431:Ethanol / Q000633:toxicity*; D005609:Free Radicals; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D011794:Quercetin / Q000494:pharmacology; D011796:Quinacrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013272:Stomach Diseases / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D013438:Sulfhydryl Compounds; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D013438:Sulfhydryl Compounds; D002084:Butylated Hydroxytoluene; D000431:Ethanol; D011794:Quercetin; D007501:Iron; D014969:Xanthine Oxidase; D011796:Quinacrine