Biologically active lipids. Semi-synthesis of 3H-labeled ether glycerophospholipids and ether glyceroglycolipids from ratfish liver oil.
1-O-Alkyl-2,3-diacyl-sn-glycerols, the major constituents of ratfish (Chimaera monstrosa) liver oil, serve as starting material for the preparation of 1-O-alkyl-sn-glycero-3-phosphocholines, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholines, 1-O-alkyl-2-O-methyl-sn-glycero-3-phosphocholines, and 1-O-alkyl-2-O-methyl-sn-glycero-3-beta-D-glucopyranosides. Catalytic tritiation of the unsaturated alkyl moieties in these biologically active ether lipids affords the corresponding 3H-labeled substances.
D000818:Animals; D004987:Ethers / Q000032:analysis*; D005395:Fish Oils / Q000032:analysis*; D005399:Fishes; D010713:Phosphatidylcholines / Q000032:analysis*; D010972:Platelet Activating Factor / Q000031:analogs & derivatives / Q000302:isolation & purification
D004987:Ethers; D005395:Fish Oils; C029271:O-deacetyl platelet activating factor; D010713:Phosphatidylcholines; D010972:Platelet Activating Factor