Acute toxicity of the major alkaloids of cultivated Lupinus angustifolius seed to rats.
The seed of modern cultivars of Lupinus angustifolius normally contain less than 0.03% alkaloids. The acute oral LD50 to rats of a pro rata mixture of the alkaloids of L. angustifolius seed was found to be 2279 mg/kg. For lupanine the LD50 by oral administration was 1464 mg/kg and by intraperitoneal injection 177 mg/kg. For 13-hydroxylupanine the LD50 by intraperitoneal injection was 199 mg/kg. Since these two alkaloids comprise about 85% of the total and are known to be rapidly cleared from the body it is suggested that the alkaloids in this species do not pose a health problem for man.
D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D006863:Hydrogen-Ion Concentration; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012639:Seeds; D013034:Sparteine / Q000031:analogs & derivatives
D000470:Alkaloids; C008298:lupanine; D013034:Sparteine