title: The effects of hypertonic salicylate on neutrophil migration and vascularization in the rat cornea.
abstract: Thermal cauterization of the center of the rat cornea results in emigration of neutrophils into the extravascular limbal tissue and blood vessel growth into the cornea. In this study, 1.0 M sodium salicylate, 1.0 M sodium chloride, and ointment vehicle were administered to normal and cauterized rat corneas for periods of 6, 48, and 144 h. When applied to the normal cornea, salicylate resulted in a marked increase in neutrophils in the limbal tissue at 6 h, but an inhibition at 48 h. Similarly, for the cauterized corneas, administration of salicylate increased the extent of neutrophil emigration at 6 h, but this effect was not sustained at 48 h. Neither vehicle nor sodium chloride had any effect on the extravascular neutrophil population. After 6 days, administration of the vehicle resulted in a slight increase in vascular growth into the cornea, whereas sodium salicylate caused a decrease. These findings indicate that hypertonic (1 M) sodium salicylate does not inhibit the emigration of neutrophils from limbal vessels of cauterized rat corneas, but does appear to have a cytotoxic effect on the tissues and on blood vessel endothelial cells.
mesh_terms: D000818:Animals; D002425:Cautery; D003315:Cornea / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D065306:Corneal Injuries; D005126:Eye Burns / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006982:Hypertonic Solutions; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012980:Sodium Salicylate / Q000494:pharmacology*
chemical_list: D006982:Hypertonic Solutions; D012980:Sodium Salicylate