Consumption of platelets in decompression sickness of rabbits.
Platelet behavior was studied in rabbit decompression sickness which was brought about by the exposure to 6 ATA for 40 min (bottom time) followed by rapid decompression. Platelet counts significantly decreased after the decompression. Kinetic studies with 111In-oxine-labeled platelets revealed shortened survivals of circulating platelets, and audioradiograms indicated the accumulation of radioactivity in the lungs after the decompression. Although there was no change in the mode volume of platelets after the decompression, the transient appearance of circulating smaller or fragmented platelets suggested a random overdestruction of platelets. Whole and releasable adenine nucleotide contents of platelets were decreased significantly after the decompression. There were no significant changes in cytoplasmic adenine nucleotide contents. Therefore, in decompression sickness, the circulating platelets behaved similarly to those in acquired storage pool disease. Platelet thrombi were found in the pulmonary arteries, compatible with the accumulation of 111In-oxine-labeled platelets. These findings suggest that circulating air bubbles interact with platelets, causing the platelet release reaction, and these activated platelets participate in the formation of thrombi in experimental decompression sickness.
D000227:Adenine Nucleotides / Q000097:blood; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism / Q000473:pathology*; D002470:Cell Survival; D003665:Decompression Sickness / Q000097:blood* / Q000150:complications / Q000473:pathology; D007700:Kinetics; D008297:Male; D010976:Platelet Count; D011655:Pulmonary Embolism / Q000209:etiology / Q000473:pathology; D011817:Rabbits
D000227:Adenine Nucleotides