Fosfomycin protects against tubulotoxicity induced by cis-diaminedichloroplatin and cyclosporin A in the rat.
The nephroprotective effect of fosfomycin against tubulotoxicity induced by cis-diaminedichloroplatin (DDP) and cyclosporin A (Cs) was studied in the rat. The parameter of nephrotoxicity was urinary tubular cell excretion. The experiments revealed that fosfomycin, given either concomitantly or in advance was able to reduce the nephrotoxic effect of DDP and Cs significantly. We conclude from these studies that fosfomycin is a broad-spectrum nephroprotective agent.
D000818:Animals; D002945:Cisplatin / Q000633:toxicity*; D003524:Cyclosporins / Q000633:toxicity*; D005260:Female; D005578:Fosfomycin / Q000494:pharmacology*; D007684:Kidney Tubules / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D003524:Cyclosporins; D005578:Fosfomycin; D002945:Cisplatin