title: Elimination of 16-acetyl-gitoxin in patients suffering from impaired liver function.
abstract: In ten patients suffering from moderate to severe disturbances of liver function (hepatic cirrhosis, carcinomatous metastases of the liver) the elimination of 16-acetyl-gitoxin from plasma was measured after a single oral dose of 1.2 mg pengitoxin. In 9 of 10 patients the mean half-life amounted to 67.3 h (SD 14.2 h). In one patient with carcinomatous infiltration of the liver and concomitant cirrhosis, the half-life was prolonged to 165.3 h. The results point to an unchanged elimination of 16-acetyl-gitoxin in patients suffering from liver cirrhosis.
mesh_terms: D000113:Acetyldigoxins / Q000097:blood* / Q000378:metabolism*; D000328:Adult; D000368:Aged; D001711:Biotransformation; D004077:Digoxin / Q000031:analogs & derivatives*; D006207:Half-Life; D006801:Humans; D008107:Liver Diseases / Q000097:blood*; D008875:Middle Aged
chemical_list: D000113:Acetyldigoxins; C016034:pentaacetylgitoxin; C025972:16-acetylgitoxin; D004077:Digoxin