title: Contrasting effects of testicular and ovarian steroids upon muscarinic binding sites in the brain.
abstract: In adult rats, testosterone increases the saturation binding capacity of hypothalamic and amygdaloid membrane fragments for the muscarinic antagonist, N-methyl scopolamine. In contrast, both estradiol and progesterone decrease binding capacity. There are sexual differences in muscarinic binding capacity and these are dependent upon perinatal exposure to androgens.
mesh_terms: D000679:Amygdala / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D008297:Male; D019832:N-Methylscopolamine; D010053:Ovary / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000187:drug effects*; D012602:Scopolamine Derivatives / Q000494:pharmacology; D012737:Sex Factors; D013256:Steroids / Q000494:pharmacology*; D013737:Testis / Q000502:physiology*; D013739:Testosterone / Q000494:pharmacology
chemical_list: D011976:Receptors, Muscarinic; D012602:Scopolamine Derivatives; D013256:Steroids; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D019832:N-Methylscopolamine