Glycerol-induced changes in the cochlear responses of the guinea pig hydropic ear.
Pigmented guinea pigs were chronically implanted with bilateral round-window electrodes. Endolymphatic hydrops was induced by obstruction of the endolymphatic duct on one side. At 1-5 months post-surgery, glycerol was orally administered to each animal and the acute effect on cochlear and eighth nerve responses was investigated. Doses from half to four times the clinical dose of glycerol failed to improve the CAP audiogram in operated ears and were often found to raise the thresholds. Glycerol was found to diminish the amplitude of the summating potential as well as that of the compound action potential. Similar effects were observed for the higher doses in the control ears, although no effect was seen when doses used were equal to or less than the clinical dose. Our data suggest that the cochlear conditions in the guinea pig model of hydrops differ notably from those seen in patients with Ménière's disease.
D000818:Animals; D001300:Audiometry, Evoked Response; D003056:Cochlear Nerve / Q000187:drug effects / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000503:physiopathology; D004711:Endolymphatic Duct / Q000503:physiopathology; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005990:Glycerol / Q000494:pharmacology*; D006168:Guinea Pigs; D007759:Labyrinth Diseases / Q000503:physiopathology; D008575:Meniere Disease / Q000503:physiopathology*
D005990:Glycerol