[Dissociation of the anti-amnesic and antihypoxic effects of nootropic and antihypoxic preparations].
In experimental studies on mice it was shown that piracetam, Cleregil, centrophenoxine, pyritinol possessed the most pronounced anti-amnestic activity. A close effect was noted with Euclidan, 3-hydroxypyridine and ionol. GABAergic agents (sodium oxybutyrate, phenibut, pantogam), gutimine, nicotinoyl-GABA eliminated amnesia to a lesser extent. The antihypoxic effect on the model of hypobaric hypoxia was exerted by typical antihypoxic agents (gutimine, sodium oxybutyrate, 3-hydroxypyridine). The antihypoxic activity of nootropic drugs (centrophenoxine, pyritinol, phenibut) could be determined only at a significant increase of doses. No interrelationship and the presence of dissociation in manifestation of anti-amnestic and antihypoxic effects were revealed.
D000647:Amnesia / Q000188:drug therapy*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003214:Conditioning, Classical / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D004924:Escape Reaction / Q000187:drug effects; D000860:Hypoxia / Q000188:drug therapy*; D008297:Male; D051379:Mice; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
D000975:Antioxidants; D011619:Psychotropic Drugs
Dissotsiatsiia antiamnesticheskogo i protivogipoksicheskogo éffektov u nootropnykh i protivogipoksicheskikh preparatov.