[Apramycin blood concentrations and distribution in the body of calves after different methods of administration].
The serum concentrations of apramycin in calves were studied after i/v application at the rate of 20 mg/kg body mass, after i/m injection at 20-40 mg/kg b. m., and after oral administration (with milk) at 40 mg/kg b. m. in terms of establishing certain pharmacokinetic parameters. It was found that at i/v route of application the concentrations of the antibiotic ranged above 2 micrograms/cm3 within the interval from the 15th min up to the 8h hour. The time of half-distribution (t1/2 alpha) was 0.28 h, while the biologic half-life of half-elimination (t1/2 beta) was 2.31 h. After muscular application of apramycin at 20 and 40 mg/kg it was rapidly adsorbed at the site of injection; the maximum concentrations were 99 micrograms/cm3 and 202 micrograms/cm3, resp., from the first to the second hour. Levels above 2 micrograms/cm3 were found in the blood serum in the course of 8 to 10 hours when the antibiotic was applied at 20 mg/kg b. m., and they have persisted for more than 12 hours when it was administered at the rate of 40 mg/kg. The biologic half-life (t1/2 beta) was 1.63 h and 1.97 h, respectively. Following the oral administration of the antibiotic at 40 mg/kg subtherapeutic levels were established up to the 24 th hour, with the exception of the interval of the 6 th to 8 th when the concentrations were below the minimum therapeutic one (2 micrograms/cm3).(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001822:Body Burden; D002417:Cattle / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D008297:Male; D008460:Meat / Q000032:analysis; D009328:Nebramycin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D009328:Nebramycin; C011666:apramycin
Krŭvni kontsentratsii i razpredelenie na apramitsina v organizma na teleta sled razlichni nachini na prilagane.