Cytogenetic effects of trifluoperazine in mice.
The cytogenetic effects of trifluoperazine have been studied in male Swiss albino mice using the micronucleus test, chromosomal analysis in germ cells and a sperm morphology assay. The mice were treated by gavage with 80, 120 or 160 micrograms trifluoperazine/kg, divided in each case into two equal doses given 24 hr apart. The dose levels were selected on the basis of standard human therapeutic dosage. Compared with the findings in control mice dosed with distilled water, there were significant increases in the frequency of micronuclei, of chromosomal aberrations in the spermatocytes and of abnormal sperms, at all the levels of trifluoperazine treatment.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects; D002869:Chromosome Aberrations; D004912:Erythrocytes / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D051379:Mice; D009153:Mutagens; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects; D014268:Trifluoperazine / Q000633:toxicity*
D009153:Mutagens; D014268:Trifluoperazine