Stereoselectivity of the inhibiting effects of baclofen on the electrogenesis of the rat cortex under ischemia.
Gamma-aminobutyric acid and dl-baclofen decrease the resistance against ischemia appraised by the number of ischemic episodes tolerated before electrocorticographic silence or cardiac arrest. D-enantiomer of baclofen does not exhibit this deleterious result in high doses either; it even counteracts the effect of its racemate and that of GABA. These data suggest that, in the brain, GABA and baclofen act at the same GABA-B receptor. This is in contrast to the existence of two distinct receptors demonstrated for the antinociceptive effects on the spinal cord.
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D002545:Brain Ischemia / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D004562:Electrocardiography; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
D001418:Baclofen