Cochlear neural degeneration without hair cell loss in two patients with aminoglycoside ototoxicity.
The temporal bones of two young adults who developed auditory toxicity during or shortly after a course of aminoglycoside therapy were examined by using light microscopy. Although the organs of Corti were essentially normal, the total number of cochlear ganglion cells was about one-third lower than the number observed in comparable subjects with normal hearing.
D000328:Adult; D003051:Cochlea / Q000187:drug effects / Q000473:pathology*; D005260:Female; D005839:Gentamicins / Q000009:adverse effects*; D006198:Hair Cells, Auditory / Q000473:pathology; D006311:Hearing Disorders / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007759:Labyrinth Diseases / Q000139:chemically induced / Q000473:pathology; D008297:Male; D009410:Nerve Degeneration; D009925:Organ of Corti / Q000473:pathology; D013136:Spiral Ganglion / Q000187:drug effects / Q000473:pathology*; D013307:Streptomycin / Q000009:adverse effects*; D013701:Temporal Bone / Q000473:pathology
D005839:Gentamicins; D013307:Streptomycin