Modifications of primaquine as antimalarials. 4. 5-Alkoxy derivatives of primaquine.
Thirty-two 5-alkoxyprimaquines have been synthesized and evaluated as blood schizonticides (Plasmodium berghei, mouse) and tissue schizonticides (Plasmodium cynomolgi, monkey). Several of these compounds were extremely active in both screens. Such a broad spectrum of antimalarial efficacy offers the possibility of a single drug that could cure the various relapsing and nonrelapsing malarias.
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D011319:Primaquine / Q000031:analogs & derivatives*; D013329:Structure-Activity Relationship
D000962:Antimalarials; D011319:Primaquine