title: In vitro antimutagenicity of curcumin against environmental mutagens.
abstract: The effects of curcumin, the yellow pigment of the spice, turmeric (Curcuma longa) on the mutagenicity of several environmental mutagens were investigated in the Salmonella/microsome test with or without Aroclor 1254-induced rat-liver homogenate (S-9 mix). With Salmonella typhimurium strain TA98 in the presence of S-9 mix, curcumin inhibited the mutagenicity of bidi and cigarette smoke condensates, tobacco and masheri extracts, benzo[a]pyrne and dimethyl benzo[a]anthracene in a dose-dependent manner. Curcumin did not influence the mutagenicity without S-9 mix of sodium azide, monoacetylhydrazine and streptozocin in strain TA100 nor of 4-nitrophenylenediamine in strain TA98. Our observations indicate that curcumin may alter the metabolic activation and detoxification of mutagens.
mesh_terms: D000818:Animals; D001711:Biotransformation; D002274:Carcinogens, Environmental / Q000037:antagonists & inhibitors*; D002396:Catechols / Q000494:pharmacology*; D003474:Curcumin / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism; D009154:Mutation; D010936:Plant Extracts; D010947:Plants, Toxic; D051381:Rats; D011919:Rats, Inbred Strains; D012906:Smoke / Q000009:adverse effects; D014026:Nicotiana
chemical_list: D002274:Carcinogens, Environmental; D002396:Catechols; D009153:Mutagens; D010936:Plant Extracts; D012906:Smoke; C057607:masheri; D003474:Curcumin