[Pharmacological study of TJ-8007 (Tsumura-Zokumeito) (I): Protective effects of TJ-8007 against anoxic brain damage].
The protective effects of TJ-8007 (Tsumura-Zokumeito, Traditional chinese medicine) against cerebral anoxia were investigated with various experimental models in mice and rats. 1) In histotoxic anoxia, TJ-8007 (0.3-3.0 g/kg, p.o.) dose-dependently demonstrated a protective effect on coma induced by a sublethal dose of KCN (1.8 mg/kg, i.v.) in mice. Ifenprodil (30 mg/kg, p.o.) tended to reduce the coma time, but papaverine (100 mg/kg, p.o.) showed a negative effect. 2) TJ-8007 (0.3-3.0 g/kg, p.o.) dose-dependently tended to prolong the survival time of mice subjected to a lethal dose of KCN (3.0 mg/kg, i.v.), TJ-8007 also improved the survival rate at the dose of 3.0 g/kg. Ifenprodil (30 mg/kg, p.o.) or papaverine (100 mg/kg, p.o.) exerted a similar effect on the survival time, but did not affect the mortality. 3) In the normobaric hypoxia with a gas mixture of 96% N2 and 4% O2, TJ-8007 (0.3-3.0 g/kg, p.o.) did not affect the survival time of mice. On the other hand, papaverine (100 mg/kg, p.o.) prolonged the survival time, and phenytoin (100 mg/kg, p.o.) showed a marked protective effect, but ifenprodil (30 mg/kg, p.o.) produced an adverse effect. 4) In the asphyxic anoxia induced by stopping artificial respiration of immovable rats, TJ-8007 (1.0, 3.0 g/kg, p.o.) showed a protective effect on the fall of systemic blood pressure and on the decline of heart rate; furthermore, it dose-dependently prolonged the disappearance time of cortical activity. Also, phenytoin (100 mg/kg, p.o.) tended to protect against the fall of blood pressure and prolonged the cortical resistance time.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D001925:Brain Damage, Chronic / Q000517:prevention & control*; D003128:Coma / Q000139:chemically induced / Q000188:drug therapy; D004365:Drugs, Chinese Herbal; D002534:Hypoxia, Brain / Q000188:drug therapy*; D008297:Male; D008516:Medicine, Chinese Traditional; D008518:Medicine, East Asian Traditional; D051379:Mice; D010208:Papaverine / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use*; D011190:Potassium Cyanide / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains
D004365:Drugs, Chinese Herbal; D010880:Piperidines; D010936:Plant Extracts; C053241:Tsumura-Zokumeito; D010672:Phenytoin; D010208:Papaverine; D011190:Potassium Cyanide; C010739:ifenprodil