title: Overfeeding during early pregnancy reduces peripheral progesterone concentration and pregnancy rate in sheep.
abstract: The 330 Merino ewes used in the study were placed with rams at a synchronized oestrus and, on Days 2-14 after mating, the ewes were placed in a feed lot and fed daily a low, medium or high ration (25%, 100% or 200% of maintenance respectively). Progesterone supplement was given to some ewes on Days 8-14 after mating by using a device containing 340 mg progesterone. Blood samples were taken from all ewes on Day 12 for measurement of plasma progesterone concentrations. On Day 14 after mating all ewes were returned to pasture. Pregnancy rate was determined by returns to oestrus and was later confirmed using ultrasound. There was a decline in the peripheral progesterone concentrations with increasing ration. The pregnancy rate in ewes fed a high ration was significantly reduced when compared with those of ewes fed a medium or low ration (48% vs 68 and 67% respectively; P less than 0.05). In ewes fed the high ration exogenous progesterone increased the pregnancy rate from 48 to 76% (P less than 0.01). Progesterone treatment did not influence pregnancy rates in ewes fed medium or low rations. The number of fetuses per ewe pregnant was not influenced by level of nutrition or progesterone treatment.
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D005260:Female; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood*; D011374:Progesterone / Q000097:blood* / Q000494:pharmacology; D012756:Sheep / Q000502:physiology*
chemical_list: D011374:Progesterone