title: The effects of simultaneous atropine and labetalol administration on cardiovascular parameters during anticholinesterase poisoning in anaesthetized cat.
abstract: The effects of atropine administration during anticholinesterase poisoning on heart rate, blood pressure and electrocardiographic changes (ECG) were studied in the cat. Administration of atropine intravenously during anticholinesterase poisoning caused a significant increase in heart rate and blood pressure; ECG changes were also seen. The simultaneous intravenous administration of atropine and labetalol during anticholinesterase poisoning abolished the increase in blood pressure and heart rate; ECG readings remained normal. It is suggested that labetalol may be a useful adjuvant in the treatment of anticholinesterase poisoning especially in patients with compromised heart function.
mesh_terms: D000818:Animals; D001285:Atropine / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D002415:Cats; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007741:Labetalol / Q000627:therapeutic use*; D008297:Male; D009388:Neostigmine / Q000506:poisoning
chemical_list: D002800:Cholinesterase Inhibitors; D009388:Neostigmine; D001285:Atropine; D007741:Labetalol