Dynamic uptake of radioactive substance in rat salivary gland following 3H-melatonin administration.
Dynamics of radioactive accumulation in rat greater salivary gland following systemic administration of 3H-melatonin was studied to determine a possible action of the hormone in the gland. Progressive decline of 3H-melatonin concentrations was found in the serum, lung, skeletal muscle, liver, kidney, and salivary gland during 60 min following the administration. On the contrary, there was a progressive accumulation of radioactive substance other than 3H-melatonin in the salivary gland but not in other tissues mentioned. The radioactivity was also progressively and preferentially localized in the nuclear fraction of the gland cells. These results suggest a possible direct action of melatonin derivative in rat salivary gland.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012469:Salivary Glands / Q000378:metabolism*; D014018:Tissue Distribution; D014316:Tritium
D014316:Tritium; D008550:Melatonin