Complement dependent in vitro neutralization of Chlamydia trachomatis by a subspecies-specific monoclonal antibody.
Three murine monoclonal antibodies which combined specifically with Chlamydia trachomatis strain HAR-13 (Serotype A) were characterized. All antibodies cross-reacted with subspecies-specific epitopes in previously undescribed patterns. One of the antibodies showed a complement-dependent partial neutralization of strain HAR-13 in vitro, whereas the remaining two antibodies did not neutralize under any experimental conditions tested. The significance of subspecies-specific antibodies in neutralizing chlamydial infectivity in vivo remains to be determined.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D002692:Chlamydia trachomatis / Q000145:classification / Q000276:immunology*; D003165:Complement System Proteins / Q000276:immunology*; D003429:Cross Reactions; D051379:Mice; D009500:Neutralization Tests; D012703:Serotyping; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D003165:Complement System Proteins