Insulin-like growth factor-I modulates endothelial cell chemotaxis.
Insulin-like growth factor-I (IGF-I) significantly promoted chemotaxis in three separate endothelial cell lines at concentrations ranging from 4 to 150 ng/ml. When added to minimum essential medium (MEM) supplemented with 1% fetal calf serum, IGF-I augmented chemotaxis to a level equalling the maximal chemotactic effect obtainable with MEM supplemented with 10% fetal calf serum (FCS 10%). The data are compatible with a potential role for IGF-I in neovascularization.
D000818:Animals; D001011:Aorta / Q000187:drug effects; D002196:Capillaries / Q000187:drug effects; D002417:Cattle; D002460:Cell Line; D002633:Chemotaxis / Q000187:drug effects*; D004727:Endothelium / Q000187:drug effects*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D012160:Retina / Q000098:blood supply; D013002:Somatomedins / Q000494:pharmacology*
D013002:Somatomedins; D007334:Insulin-Like Growth Factor I