Prevention of cysteamine-induced myoclonus blocks the long-term inhibition of kindled seizures.
In kindled rats, the administration of cysteamine (CSH, 200 mg/kg, i.p.) 4 h prior to a kindled seizure leads to long-term (up to 10 days) inhibition of kindled seizures. CSH (200 mg/kg, i.p.) also induces myoclonic seizures in kindled rats. We suggest that the long-term inhibition of kindled seizures might be the result of the myoclonus, not the somatostatin depletion as previously suggested. Prior administration of the short-acting benzodiazepine midazolam (5 mg/kg, i.p.) eliminated the CSH-induced myoclonus and prevented the long-term inhibition of kindled seizures. These results suggest that the CSH-induced long-term inhibition of kindled seizures is the result of an interaction between the myoclonic seizure and a subsequent kindled seizure.
D000818:Animals; D003543:Cysteamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007696:Kindling, Neurologic; D008297:Male; D008874:Midazolam / Q000494:pharmacology; D009207:Myoclonus / Q000139:chemically induced / Q000517:prevention & control*; D009433:Neural Inhibition; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000209:etiology*
D003543:Cysteamine; D008874:Midazolam