The effect of cadmium ions on 2,3-bisphosphoglycerate in erythrocytes studied with 31P NMR.
The interaction of cadmium ions with human red blood cell (RBC) 2,3-bisphosphoglycerate (DPG) wasa studied by 31P NMR. 31P NMR spectra and 31P T1 and 31P T2 relaxation times give evidence for cadmium-2,3-bisphosphoglycerate complexation in aqueous solution. 31P NMR spectra indicate the occurrence of a similar complexation in RBC cryolysates. The lag phase (constant polyphosphate level) prior to DPG hydrolysis in incubated red blood cells is lengthened in the presence of cadmium.
D019794:2,3-Diphosphoglycerate; D001793:Blood Preservation; D002104:Cadmium / Q000378:metabolism*; D004163:Diphosphoglyceric Acids / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D005615:Freezing; D006801:Humans; D009682:Magnetic Resonance Spectroscopy
D004163:Diphosphoglyceric Acids; D002104:Cadmium; D019794:2,3-Diphosphoglycerate