title: Lymphoepithelial lesion and Sjögren's syndrome.
abstract: The lymphoepithelial lesion of salivary glands, which begins with a focal, periductal lymphoreticular reaction and progresses to partial or total replacement of functioning acinar parenchyma, is associated with several clinical disorders. The lesion may be solely a salivary gland disease without systemic manifestations or may be a tissue manifestation of autoimmune disease--primary or secondary Sjögren's syndrome. Besides its own morbidity, the lesion is associated with the development of lymphomas.
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis / Q000473:pathology; D012466:Salivary Gland Diseases / Q000175:diagnosis / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000473:pathology; D012469:Salivary Glands / Q000473:pathology; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000473:pathology*