[Ultrastructural study of the liver in rabbits treated with diclofenac].
The existence of alterations of common indexes of hepatic function, and the case-reports of acute hepatitis after the use of diclofenac sodium are the rationale for this experimental study, in which 8 rabbits were given 15 mg/kg day of diclofenac, to check ultrastructural modifications with respect to a control group. The analysis showed the typical signs of primary and secondary microcholestasis, indicating the existence of liver distress. This finding, from a clinical standpoint, suggests caution in the administration of this drug, chiefly in the hepatopathic patients.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004008:Diclofenac / Q000633:toxicity*; D008099:Liver / Q000648:ultrastructure*; D008107:Liver Diseases / Q000473:pathology; D008854:Microscopy, Electron; D011817:Rabbits
D004008:Diclofenac
Studio ultrastrutturale epatico in conigli trattati con diclofenac.