Familial occurrence of big-big prolactin as the predominant immunoreactive human prolactin species in blood.
The occurrence of big-big prolactin (PRL) as the major form of circulating immunoactive PRL has been described in ovulatory hyperprolactinemia. In this study, we have analyzed the heterogeneity of circulating human PRL in 17 members of three families in which one member, bearing galactorrhea-hyperprolactinemic syndrome, was known to have serum big-big PRL as the predominant circulating species. Gel filtration patterns of serum samples of all subjects revealed the presence of significant proportions of big-big PRL in more than one member of the same family, thus suggesting the familial occurrence of big-big as the predominant immunoreactive PRL species in blood.
D000328:Adult; D005260:Female; D005838:Genotype; D006680:HLA Antigens / Q000032:analysis; D006238:Haploidy; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000235:genetics; D008285:Major Histocompatibility Complex; D008297:Male; D008787:Metoclopramide; D008970:Molecular Weight; D011388:Prolactin / Q000097:blood / Q000235:genetics*
D006680:HLA Antigens; D011388:Prolactin; D008787:Metoclopramide