Diagnostic imaging of gynecologic tumors with the monoclonal antibody 791T/36.
One hundred twenty-three patients with suspected primary or recurrent gynecologic cancer were imaged after infusion with radiolabeled antitumor monoclonal antibody (791T/36). Overall sensitivity of tumor detection was 87% and specificity was 75%. Indium 111- and iodine 131-labeled antibody were compared, the former yielding a higher specificity for tumor detection. This antibody shows potential for routine tumor detection, particularly in cases of suspected recurrent cancer, but the development of antimouse antibodies is a drawback to this technique still to be overcome. The specific targeting of cytotoxic agents with this antibody is in progress.
D000911:Antibodies, Monoclonal; D005260:Female; D005833:Genital Neoplasms, Female / Q000000981:diagnostic imaging*; D006801:Humans; D007204:Indium; D007457:Iodine Radioisotopes; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013997:Time Factors; D014018:Tissue Distribution
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D011868:Radioisotopes; D007204:Indium