Pitfalls in diagnosing brain death in infancy.
A 3-year-old child with phenotypic trisomy 18 syndrome survived 26 days after a cardiopulmonary arrest, secondary to an acute viral illness. The child was deeply comatose. No barbiturates, other sedatives, or aminoglycoside antibiotics had been recently administered. The child was normothermic with adequate cardiovascular function. Brain stem function was absent, as assessed by testing of brain stem reflexes. Serial cerebral radionuclide angiograms (CRAG) documented intact cerebral blood flow while electrocerebral silence (ECS) was present on two consecutive EEG recordings within 24 hours. Preservation of intracranial circulation was confirmed by rapid rotational computed tomographic (CT) scans. Cranial CT scans also revealed communicating hydrocephalus, and bilateral basal ganglia hemorrhages. This unusual case illustrates discordance between apparent irreversible loss of cortical function as indicated by electrocerebral silence with preserved cerebral blood flow. The implications of these apparent paradoxical events will be discussed in the context of defining brain death in children.
D001926:Brain Death; D002560:Cerebrovascular Circulation; D002675:Child, Preschool; D002887:Chromosomes, Human, Pair 18; D004569:Electroencephalography; D005071:Evoked Potentials; D006323:Heart Arrest / Q000150:complications*; D006801:Humans; D008297:Male; D015609:Organotechnetium Compounds; D013400:Sugar Acids; D013667:Technetium; D014314:Trisomy
D015609:Organotechnetium Compounds; D013400:Sugar Acids; D013667:Technetium; C100014:technetium Tc 99m gluceptate