title: Perioperative antibiotic prophylaxis in bile-duct interventions: results of two prospective randomized studies.
abstract: The success of perioperative prophylaxis in gallbladder surgery was examined in two prospective randomized studies with a total of 326 patients. Postoperative wound-healing impairments did not occur in any of the patients receiving a single preoperative application of an antibiotic with a high biliary elimination rate (ceftriaxone or apalcillin). 11% of a control group without prophylactic antibiotic application evidenced infectious wound-healing disturbances.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000667:Ampicillin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001649:Bile Duct Diseases / Q000601:surgery; D002443:Ceftriaxone / Q000627:therapeutic use*; D002769:Cholelithiasis / Q000601:surgery*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009287:Naphthyridines; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D014945:Wound Healing / Q000187:drug effects
chemical_list: D009287:Naphthyridines; C012122:apalcillin; D002443:Ceftriaxone; D000667:Ampicillin