Pulmonary marrow embolism: a dog model simulating dual component cemented arthroplasty.
The cardiopulmonary changes resulting from cemented arthroplasty procedures were monitored in 11 dogs with a single prosthesis implanted and nine dogs with a dual arthroplasty procedure. These changes were characterized by decreased BP, elevated PPA, and elevated PVR, associated with decreases in PaO2, cardiac output and mixed venous oxygen tension. All changes were more pronounced and prolonged in the dual component arthroplasty group. Histologic lung examination and morphometry demonstrated significant degrees of marrow (fat) microembolism in the dual arthroplasty model. Cardiopulmonary collapse has been associated with Guepar dual component arthroplasties clinically and these patients are at increased risk and should be monitored continuously. Prophylactic measures include meticulous lavage of the intramedullary cavity, increased FIO2, and maintenance of intravascular volume and cardiac output. The bilateral arthroplasty model is useful in investigating therapeutic interventions which may detect and prevent the marrow microembolism syndrome intraoperatively.
D000818:Animals; D001843:Bone Cements / Q000009:adverse effects; D001853:Bone Marrow / Q000601:surgery; D004285:Dogs; D004620:Embolism, Fat / Q000209:etiology; D006439:Hemodynamics; D007595:Joint Prosthesis / Q000009:adverse effects*; D010100:Oxygen / Q000097:blood; D011655:Pulmonary Embolism / Q000209:etiology* / Q000517:prevention & control; D011659:Pulmonary Gas Exchange
D001843:Bone Cements; D010100:Oxygen