Contraction-associated translocation of protein kinase C in rat skeletal muscle.
Electrical stimulation of the sciatic nerve of the anaesthetized rat in vivo led to a time-dependent translocation of protein kinase C from the muscle cytosol to the particulate fraction. Maximum activity of protein kinase C in the particulate fraction occurred after 2 min of intermittent short tetanic contractions of the gastrocnemius-plantaris-soleus muscle group and coincided with the loss of activity from the cytosol. Translocation of protein kinase C may imply a role for this kinase in contraction-initiated changes in muscle metabolism.
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000494:pharmacology; D003600:Cytosol / Q000201:enzymology; D007700:Kinetics; D008297:Male; D009119:Muscle Contraction; D009132:Muscles / Q000201:enzymology*; D010743:Phospholipids / Q000494:pharmacology; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000201:enzymology
D010743:Phospholipids; D011493:Protein Kinase C; D002118:Calcium