Genetic, iron status and sex factors of porphyria induced by hexachlorobenzene.
This study explored the influence of genetic strain, sex and iron on the development of hexachlorobenzene (HCB)-induced porphyria in mice and rats. Results are discussed in terms of the mechanism of action and comparison with human exposure to the chemical.
D000818:Animals; D002722:Chlorobenzenes / Q000633:toxicity*; D005260:Female; D006581:Hexachlorobenzene / Q000633:toxicity*; D007501:Iron / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity; D011164:Porphyrias / Q000139:chemically induced*; D051381:Rats; D012737:Sex Factors; D013045:Species Specificity; D014575:Uroporphyrinogen Decarboxylase / Q000037:antagonists & inhibitors
D002722:Chlorobenzenes; D008054:Lipid Peroxides; D000072317:Polychlorinated Dibenzodioxins; D006581:Hexachlorobenzene; D007501:Iron; D014575:Uroporphyrinogen Decarboxylase