Evaluation of fenbendazole for larvacidal effect in experimentally induced Parascaris equorum infections in pony foals.
Fifteen pony foals were inoculated with 1,500 +/- 298.7 infective Parascaris equorum eggs. The foals were assigned to 3 treatment groups. Treatments included 10 mg of fenbendazole/kg given once on postinoculation day (PID) 11, 10 mg of fenbendazole/kg given daily on PID 11 to 15, and no treatment (controls). The foals were euthanatized on PID 25 and examined for P equorum larvae in the small intestine, lungs, and liver. Significantly (P less than 0.05) lower mean numbers of P equorum larvae were found in the small intestine of foals treated on PID 11 to 15 (1.4 [range, 0 to 6]) than in the small intestine of foals treated on PID 11 (428.2 [range, 0 to 777]) and in controls (500 [range, 284 to 802]).
D000818:Animals; D000831:Animals, Newborn; D001199:Ascaridoidea / Q000187:drug effects; D001562:Benzimidazoles / Q000627:therapeutic use*; D005273:Fenbendazole / Q000627:therapeutic use*; D006734:Horse Diseases / Q000188:drug therapy* / Q000469:parasitology; D006736:Horses; D007421:Intestine, Small / Q000469:parasitology; D007814:Larva / Q000187:drug effects; D008099:Liver / Q000469:parasitology; D008168:Lung / Q000469:parasitology; D008174:Lung Diseases, Parasitic / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*
D001562:Benzimidazoles; D005273:Fenbendazole