A new antitumor antibiotic, FR-900482. II. Production, isolation, characterization and biological activity.
FR-900482 is a new antitumor antibiotic produced by a new actinomyces named Streptomyces sandaensis No. 6897. It exhibits potent cytotoxic activity against various tumor cells in vitro. Furthermore, it has weak antimicrobial activity against some Gram-positive or Gram-negative bacteria.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D001643:Bridged Bicyclo Compounds / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D010078:Oxazines; D013055:Spectrophotometry, Infrared; D013057:Spectrum Analysis; D013302:Streptomyces / Q000032:analysis*
D000903:Antibiotics, Antineoplastic; D001643:Bridged Bicyclo Compounds; D010078:Oxazines; C053335:FR 900482