[Individual differences in the levels of pain sensitivity and analgesic effect of morphine in noninbred mice].
The initial threshold of pain sensitivity and the degree of morphine analgesia (12, 12, 70 mg/kg, i. p.) were assessed during mechanical, thermal and electrical stimulation, respectively, in noninbred white male mice. Two tests were performed, the second a week after the first one. A slight positive correlation (r = +0.39) between the initial threshold of pain reaction and the analgetic effect of morphine was found only during electrical stimulation in the first test, and positive correlation between the first and the second test during electrical and mechanical stimulation (0.34 and 0.27, respectively) was determined. The degree of morphine analgesia in different animals during second testing could either increase or decrease. It is suggested that previous testing of morphine analgetic effect cannot predict the efficacy of analgesia during the second testing and that the initial threshold of pain sensitivity cannot serve as a reliable predictor of morphine analgesia level.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology*; D010812:Physical Stimulation / Q000379:methods; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology
D009020:Morphine
Individual'nye razlichiia v urovniakh bolevoĭ chuvstvitel'nosti i anal'geziruiushchiĭ éffekt morfina u besporodnykh mysheĭ.