Aerosolized gadolinium-DTPA enhances the magnetic resonance signal of extravascular lung water.
Gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA), a contrast agent for magnetic resonance imaging, was administered by either aerosol or intravenous injection to rats. Proton relaxation times in excised lungs and kidneys were then measured. With increasing concentrations of aerosolized Gd-DTPA, the spin-lattice relaxation time (T1) of lungs decreased (enhanced) significantly (P less than .001), an effect that persisted for at least 80 minutes; there was no change in kidney T1. After intravenous injection of Gd-DTPA, lung T1 did not change, but kidney T1 decreased significantly (P less than .001), confirming previous observations of renal clearance. It is concluded that aerosolized Gd-DTPA is a more efficacious method of delivery of paramagnetic contrast agent to the lungs than intravenous injection, and that the lack of systemic effect after aerosolization indicates that enhancement was limited to the extravascular compartment.
D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D003287:Contrast Media; D005110:Extracellular Space / Q000378:metabolism*; D005682:Gadolinium / Q000008:administration & dosage; D019786:Gadolinium DTPA; D007668:Kidney / Q000033:anatomy & histology; D008168:Lung / Q000033:anatomy & histology / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000008:administration & dosage; D004369:Pentetic Acid / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains
D000336:Aerosols; D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA