[Effect pf protease inhibitors on DNA degradation in gamma-irradiated rat thymocytes].
Protease inhibitors, antipain and pepstatin, decrease the postirradiation degradation of DNA in gamma-irradiated rat thymocytes. It is suggested that a protease-dependent process of induction of DNA breaks takes place in irradiated cells.
D000818:Animals; D000976:Antipain / Q000494:pharmacology; D004247:DNA / Q000187:drug effects* / Q000528:radiation effects; D004249:DNA Damage; D004277:DNA, Single-Stranded / Q000187:drug effects / Q000528:radiation effects; D003864:Depression, Chemical; D005720:Gamma Rays; D010436:Pepstatins / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology*; D011837:Radiation-Protective Agents; D051381:Rats; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects
D004277:DNA, Single-Stranded; D010436:Pepstatins; D011480:Protease Inhibitors; D011837:Radiation-Protective Agents; C014195:Streptomyces pepsin inhibitor; D000976:Antipain; D004247:DNA; C031375:pepstatin
Vliianie ingibitorov proteaz na degradatsiiu DNK v gamma-obluchennykh timotsitakh krys.