Effects of experimental gastroduodenal reflux on density of mast cells and plasmocytes in the fundic mucosa of the rat.
IgA-, IgM-, IgG- and IgE-positive plasmocytes and mast cells were counted in the fundic mucosa of two groups of rats which underwent gastroenteroanastomosis or sham operation 12 months previously. Experimentally induced duodenogastric reflux constitutes a model for biliary gastritis which is characterized by a decrease in the IgA plasmocyte count along with an increase in IgG and IgE plasmocytes and, especially, an increase in mast cells. It is suggested that this allergic-type reaction is responsible for the hyperplasia of gastric crypts seen in biliary gastritis.
D000818:Animals; D004383:Duodenogastric Reflux / Q000276:immunology*; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology*; D005758:Gastritis, Hypertrophic / Q000276:immunology; D007136:Immunoglobulins / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000276:immunology*; D010950:Plasma Cells / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains
D007136:Immunoglobulins