Immotile cilia syndrome in an aged dog.
An 11-year-old Dalmatian was examined and treated for bilateral nasal discharge and cough of 6 months' duration. Response to medical treatment and surgical intervention was unsatisfactory. Histologic examination of lung tissue revealed chronic severe catarrhal bronchitis and bronchiolitis with bronchiectasis. Histologic findings and barium sulfate bronchography indicated abnormal mucociliary clearance in the respiratory tract. Electron microscopy revealed abnormalities or deletions of outer and/or inner dynein arms in 26% of the ciliary profiles from the affected dog. Similar abnormalities were not found in 500 ciliary profiles from age- and gender-matched control dogs.
D000818:Animals; D001995:Bronchography / Q000662:veterinary; D002923:Cilia / Q000648:ultrastructure; D002925:Ciliary Motility Disorders / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D003371:Cough / Q000209:etiology / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D004285:Dogs; D005260:Female; D008168:Lung / Q000503:physiopathology / Q000648:ultrastructure; D008854:Microscopy, Electron