Amino acid sequence and structural repeats in schistosome paramyosin match those of myosin.
The cDNA encoding about half of an antigenic non-surface schistosome parasite protein of Mr 97 K has recently been cloned and sequenced (Lanar, Pearce, James and Sher (1986) Science 234:593-596). Analysis of this sequence, together with the properties of the native protein, reveals that this protein is paramyosin, the hitherto unsequenced core protein of myosin filaments in invertebrate muscle. In this report we analyze in more detail the partial amino acid sequence of schistosome paramyosin and describe electron microscope studies of the native protein and its aggregates. We show a close correspondence between the structures of paramyosin and the myosin rod that is required for these proteins to assemble together in muscle thick filaments.
D000595:Amino Acid Sequence; D000818:Animals; D008854:Microscopy, Electron; D009218:Myosins; D011487:Protein Conformation; D012547:Schistosoma / Q000032:analysis*; D014335:Tropomyosin
D014335:Tropomyosin; D009218:Myosins