Mechanism of inhibition of junctional communication between animal cells by phorbol ester.
The tumour promotor 4 beta-phorbol 12-myristate 13-acetate (TPA) reduces the rate of junction formation between V79 Chinese hamster lung cells in culture but not between BHK21/13 Syrian hamster fibroblasts. TPA may act on all cells but only affect junction formation in those situations where the rate of junction formation is already low.
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D005347:Fibroblasts / Q000648:ultrastructure; D005561:Formates / Q000378:metabolism; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism; D007365:Intercellular Junctions / Q000187:drug effects*; D007668:Kidney / Q000648:ultrastructure; D008168:Lung / Q000648:ultrastructure; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014529:Uridine / Q000378:metabolism
D005561:Formates; D007042:Hypoxanthines; C030544:formic acid; D019271:Hypoxanthine; D013755:Tetradecanoylphorbol Acetate; D014529:Uridine