title: Pharmaceutical availability from oral dosage forms: in vitro release of nitrofurantoin from tablets and capsules.
abstract: The pharmaceutical availability of nitrofurantoin in three commercial urinary antiseptic preparations for oral use was assessed by an in vitro determination of drug release into a strongly acidic, a weakly acidic and a weakly basic medium. The following parameters are reported: t87.5%, tdiss, X0 (percentage released immediately on contact with medium), krel (relative dissolution rate constant), and dissolution efficiency (DE).
mesh_terms: D001682:Biological Availability; D002214:Capsules; D006863:Hydrogen-Ion Concentration; D009582:Nitrofurantoin / Q000008:administration & dosage* / Q000378:metabolism; D013607:Tablets
chemical_list: D002214:Capsules; D013607:Tablets; D009582:Nitrofurantoin