Factors influencing the caffeine test for cytochrome P 448-dependent liver function.
Liver functions in patients with liver disease can be estimated by caffeine clearance. Our data, however, demonstrate the additional influence of factors other than liver disease on the caffeine test. Smoking enhances caffeine clearance in both healthy volunteers and patients with severe hepatic disorders, whereas co-medication with mexiletine strongly inhibits caffeine elimination.
D002110:Caffeine / Q000652:urine*; D019388:Cytochrome P-450 CYP1A2; D003580:Cytochromes / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008107:Liver Diseases / Q000378:metabolism; D008111:Liver Function Tests; D008801:Mexiletine / Q000494:pharmacology; D012907:Smoking
D003580:Cytochromes; D008801:Mexiletine; D002110:Caffeine; C017170:Cyp1a2 protein, rat; D019388:Cytochrome P-450 CYP1A2