title: A fast algorithm for the computation of the plasma concentration time curve and confidence limits in linear pharmacokinetics.
abstract: An algorithm is developed for the computation of the plasma concentration time curve for a drug administration regime involving fast injection (bolus) and/or continuous infusion. The effect of the pharmacokinetic model parameter variations on the plasma concentration time curve is analyzed and efficient algorithms for the computation of the parameter-induced first-order variation and confidence bounds of the plasma concentration time curve are also presented. The application of the method is illustrated with pharmacokinetic data for the etomidate.
mesh_terms: D000465:Algorithms; D007700:Kinetics; D008432:Mathematical Computing; D004364:Pharmaceutical Preparations / Q000097:blood*
chemical_list: D004364:Pharmaceutical Preparations