Inhibitory effect of the ventral tegmental A10 region on the hypothalamic defence reaction: evidence for a possible dopaminergic mediation.
The influence of A10 region neurons of the ventral tegmental area (VTA) on the defence reaction evoked by stimulation of the ventromedial hypothalamic nucleus (VMH) was studied in the cat. The latency of the hissing in the defence reaction increased when the VTA was stimulated both ipsi- and contralaterally. A sulpiride (50mg/kg i.p.) injection totally abolished the VTA-provoked increase of the hissing latency without affecting the basal response.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002415:Cats; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D004558:Electric Stimulation; D007031:Hypothalamus / Q000502:physiology*; D011930:Reaction Time / Q000187:drug effects; D013469:Sulpiride / Q000494:pharmacology; D013681:Tegmentum Mesencephali / Q000187:drug effects / Q000502:physiology*
D013469:Sulpiride; D004298:Dopamine