title: Methodology of drug trials in migraine.
abstract: Treatment of migraine attacks and prophylactic treatment of migraine are discussed under the four headings: patient selection, trial design, evaluation of results and statistics. Furthermore, based on a previous multicenter prophylactic trial, crossover design was found four times more powerful than group comparison.
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D004311:Double-Blind Method; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000517:prevention & control; D013223:Statistics as Topic