C6 glioma cells express modified neural-cell adhesion molecule-like glycoproteins.
We have studied the expression of neural-cell adhesion molecule (N-CAM)-like glycoproteins in a C6 glioma cell line. We found that: (a) C6 cells express N-CAM-like proteins on the cell surface, (b) the N-CAM-like proteins in C6 cells have apparent molecular weights of 130,000 and 150,000 kDa which are not seen in rodent brain and (c) deglycosylation of C6 N-CAMs suggest that the modifications are both in the carbohydrate and protein parts of the N-CAM. The expression of modified N-CAM glycoproteins is of interest in relation to the regulation of N-CAM expression.
D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism*; D015815:Cell Adhesion Molecules; D002460:Cell Line; D004586:Electrophoresis; D005910:Glioma / Q000378:metabolism* / Q000473:pathology; D006023:Glycoproteins / Q000378:metabolism*; D008970:Molecular Weight; D009474:Neurons / Q000378:metabolism*
D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D006023:Glycoproteins