Intra blood-cerebrospinal fluid-barrier detection of hepatitis B virus.
Hepatitis B, a major public health concern worldwide, is caused by hepatitis type B virus, a hepdnavirus that infects only human and certain nonhuman primates, and replicates strictly in hepatocytes. By using the techniques of slot and Southern blot DNA hybridization, and electron microscopy, the presence of HBV was identified in the cerebrospinal fluid of three affected individuals.
D001812:Blood-Brain Barrier; D004279:DNA, Viral / Q000032:analysis; D006509:Hepatitis B / Q000134:cerebrospinal fluid*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000032:analysis* / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008722:Methods; D008854:Microscopy, Electron; D008875:Middle Aged; D009693:Nucleic Acid Hybridization
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens