Glycyrrhizin gel as a vehicle for idoxuridine--I. Clinical investigations.
The therapeutic efficacy of a new formulation that incorporates 0.2% IDU in glycyrrhizin gel has been tested on patients who suffer from herpes of the lips and nose. The preparation was significantly more effective than a commercial 0.5% IDU ointment. It reduced the healing time and produced an almost instantaneous relief from pain. The higher efficacy of the new preparation may be ascribed to the reported anti-inflammatory and antiviral activities of glycyrrhizin together with an enhanced permeation of the IDU through the skin.
D005782:Gels; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives*; D019695:Glycyrrhizic Acid; D006560:Herpes Labialis / Q000188:drug therapy; D006801:Humans; D007065:Idoxuridine / Q000008:administration & dosage* / Q000627:therapeutic use; D009824:Ointments; D014677:Pharmaceutical Vehicles
D005782:Gels; D009824:Ointments; D014677:Pharmaceutical Vehicles; D019695:Glycyrrhizic Acid; D007065:Idoxuridine; D006034:Glycyrrhetinic Acid