Brown adipose tissue metabolism in ob/ob mice: effects of a high-fat diet and adrenalectomy.
Adrenalectomy prevents development of obesity in ob/ob mice fed high-carbohydrate stock diets partly by stimulating the low thermogenic capacity of their brown adipose tissue (BAT). Adrenalectomy, however, fails to prevent development of obesity in ob/ob mice fed a high-fat diet. Effects of adrenalectomy on BAT metabolism in ob/ob mice fed a high-fat diet were thus examined. ob/ob mice fed the high-fat diet developed gross obesity despite normal BAT metabolism, as assessed by rates of norepinephrine turnover in BAT, GDP binding to BAT mitochondria, and GDP-inhibitable, chloride-induced mitochondrial swelling. Adrenalectomy failed to arrest the development of obesity or to influence BAT metabolism in ob/ob mice fed the high-fat diet. Development of obesity in ob/ob mice fed a high-fat diet is not associated with low thermogenic capacity of BAT or with adrenal secretions, as it is in ob/ob mice fed high-carbohydrate stock diets.
D002001:Adipose Tissue, Brown / Q000378:metabolism* / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D001833:Body Temperature Regulation; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D006153:Guanosine Diphosphate; D051379:Mice; D008810:Mice, Inbred C57BL; D009638:Norepinephrine / Q000378:metabolism; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology
D004041:Dietary Fats; D006153:Guanosine Diphosphate; D009638:Norepinephrine