Pharmacologic probe with progabide of GABA mechanisms in essential tremor.
Progabide, a gamma-aminobutyric acid agonist, was given to ten patients with essential tremor in a double-blind, placebo-controlled crossover study. The effect of progabide did not differ from that of placebo. Alterations in gamma-aminobutyric acid neurotransmission do not appear to be involved in the pathogenesis of essential tremor.
D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D014202:Tremor / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology*
C017985:progabide; D005680:gamma-Aminobutyric Acid