title: Correlation of choline acetyltransferase activity between the nucleus basalis of Meynert and the cerebral cortex.
abstract: Choline acetyltransferase (ChAT) activities were measured in the cerebral cortex and the nucleus basalis of Meynert (nbM) of post-mortem human brains from 8 cases with Alzheimer type dementia (ATD) and 5 age-matched control subjects. The lowest ChAT activity was detected in the temporal cortex (Brodmann's area 22) and the nbM in ATD. A significant correlation was found between ChAT activities in the nbM and those in Brodmann's areas 4, 7, 10, 17 and 22. Present results provide evidence of a cholinergic projection from the nbM to the cerebral cortex observed by retrograde or anterograde degeneration studies in animals.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology*; D001479:Basal Ganglia / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013377:Substantia Innominata / Q000201:enzymology*
chemical_list: D002795:Choline O-Acetyltransferase