Effect of dietary polyunsaturated fatty acid (PUFA) supplementation on adjuvant induced polyarthritis in rats.
Dietary treatment with fish oil reduced the severity of adjuvant induced polyarthritis in Dark Agouti rats but enhanced disease severity in Wistar-Hooded rats. The difference in effects of fish oil between strains was not related to differences in severity of disease induced in untreated rats. Genetically determined factors may influence the effects of fish oil supplementation on severity of inflammatory diseases.
D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000178:diet therapy* / Q000503:physiopathology; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use*; D004912:Erythrocytes / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D005620:Freund's Adjuvant; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012720:Severity of Illness Index
D004042:Dietary Fats, Unsaturated; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D005620:Freund's Adjuvant