[Protective effect of dicloguamine maleate (MN-1695) on HCl-induced gastric mucosal damage in rats--histologic studies].
Effect of MN-1695, a new cytoprotective antiulcer agent, on 0.2 N HCl-induced gastric surface epithelial cell damage was investigated by optical and transmission electron microscopy in rats. Tissue examination after five minutes exposure to 0.2 N HCl showed extensive damage of the surface epithelial cells: dilatation of intercellular spaces including marked edema of lamina propria. It was found that MN-1695 (3 mg/kg) pretreatment prevented such 0.2 N HCl-induced damage of the surface epithelial cells, and it reduced the percentage of damaged mucosa, but not significantly.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000473:pathology*; D006851:Hydrochloric Acid; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D014227:Triazines / Q000627:therapeutic use*
D000897:Anti-Ulcer Agents; D014227:Triazines; C041836:irsogladine; D006851:Hydrochloric Acid