Studies on phytohemagglutinin-induced peritonitis of mice: dynamics of inflammatory responses and influence of anticomplementary agents and anti-inflammatory drugs.
The intraperitoneal injection of phytohemagglutinin in the mouse resulted in the marked accumulation of leukocytes, especially macrophages, in the peritoneal cavity between 8 and 36 h after the injection. Parallel to the accumulation of macrophages, exudation of plasma proteins into the peritoneal cavity was observed. When the effect of anticomplementary agents (FUT-175 and K-76 COONa) and anti-inflammatory drugs (indomethacin and dexamethasone) on phytohemagglutinin-induced peritonitis was examined, FUT-175, K-76 COONa and indomethacin suppressed only the plasma protein exudation. On the other hand, dexamethasone suppressed both the accumulation of macrophages and the plasma protein exudation.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001550:Benzamidines; D001798:Blood Proteins / Q000032:analysis; D003169:Complement Inactivator Proteins / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use; D005122:Exudates and Transudates / Q000032:analysis; D006146:Guanidines / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010538:Peritonitis / Q000139:chemically induced*; D010835:Phytohemagglutinins; D012717:Sesquiterpenes / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D001550:Benzamidines; D001798:Blood Proteins; D003169:Complement Inactivator Proteins; D006146:Guanidines; D010835:Phytohemagglutinins; D012717:Sesquiterpenes; C038797:K 76 carboxylic acid; D003907:Dexamethasone; D007213:Indomethacin; C032855:nafamostat