Inhibitors of sterol synthesis. Dietary administration of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one inhibits the intestinal absorption of cholesterol in lymph-cannulated rats.
The effect of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of cholesterol synthesis with marked hypocholesterolemic activity, on the intestinal absorption of exogenous cholesterol has been studied in lymph-cannulated rats. Administration of the 15-ketosterol at a level of 0.05% in a rat chow diet for 10 days was associated with a marked decrease (-64%) in the absorption of cholesterol.
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002782:Cholestenes / Q000494:pharmacology*; D002783:Cholestenones / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism*; D004435:Eating / Q000187:drug effects; D007408:Intestinal Absorption / Q000187:drug effects*; D007700:Kinetics; D008196:Lymph / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000924:Anticholesteremic Agents; D002782:Cholestenes; D002783:Cholestenones; C015073:cholest-8(14)-en-3-ol-15-one; D002784:Cholesterol