[5-Iododeoxyuridine as well as 5-bromodeoxyuridine induce the formation of specific dicentric chromosomes in cells with micronuclei].
5-iododeoxyuridine used instead of 5-bromodeoxyuridine for the induction of delayed disruption of telomeric links between chromosomes in polykaryocytes consisting of micronuclei was studied. It has been shown that treatment with 5-iododeoxyuridine (20 micrograms/ml) and colcemide (0.1 microgram/ml) for 42 hours induced the dicentric formation. Dicentrics were tested in 27% of all metaphases. This index was lower in comparison with 5-bromodeoxyuridine used for the same purpose.
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002467:Cell Nucleus / Q000187:drug effects*; D002503:Centromere / Q000187:drug effects*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D002999:Clone Cells / Q000187:drug effects; D003703:Demecolcine / Q000494:pharmacology; D007065:Idoxuridine / Q000494:pharmacology*; D008677:Metaphase / Q000187:drug effects; D013997:Time Factors
D001973:Bromodeoxyuridine; D007065:Idoxuridine; D003703:Demecolcine
5-Ioddezoksiuridin, tak zhe kak i 5-bromdezoksiuridin, indutsiruet obrazovanie spetsificheskikh ditsentricheskikh khromosom v kletkakh s mikroiadrami.