title: Clinical manifestation of glioma before computed tomographic appearance: the dilemma of a negative scan.
abstract: Eight cases are presented to summarize our experience with patients initially evaluated for the new onset of either seizure activity or focal transient neurological deficits. Each was found to have a normal computed tomographic (CT) scan with and without iodinated contrast infusion. All subsequently returned with a CT scan indicative of a glioma 2 weeks to 39 months later. The apparent reasons for the difficulty in early diagnosis of glioma in certain instances are discussed. A review of the literature with an analysis of the conglomerate data is presented. These cases probably represent a subset of gliomas undergoing anaplastic dedifferentiation from relatively benign to more malignant forms. Recommendations for clinical and radiographic follow-up are outlined.
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D002533:Cerebral Angiography; D003937:Diagnosis, Differential; D004569:Electroencephalography; D005260:Female; D005910:Glioma / Q000000981:diagnostic imaging* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed