title: Presence of salicylic acid in standardbred horse urine and plasma after various feed and drug administrations.
abstract: Plasma and urinary levels of salicylic acid were examined in Standardbred mares after administration of various feeds, containing different compositions of hay. In addition, horses were administered acetylsalicylic acid orally and methyl salicylate topically. Elevated salicylic acid levels were observed in horse urine and plasma in animals fed lucerne hay. The plasma and urinary elimination of salicylic acid exhibited a diurnal pattern which was related to the type of feed and the feeding schedule. Within 24 h after oral administration of acetylsalicylic acid, plasma and urine salicylic acid levels were consistent with residual levels observed after feeding lucerne hay. Elimination of salicylic acid was rapid and complete, with a half-life between 5 and 7 h. Topical administration of methyl salicylate (8.4 g) produced elevated urinary salicylic acid levels for 6 h. A smaller dose of methyl salicylate (3.4 g) did not elevate plasma or urine salicylic acid levels above those observed following administration of lucerne hay.
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000821:Animal Feed; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006736:Horses / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006863:Hydrogen-Ion Concentration; D012459:Salicylates / Q000008:administration & dosage* / Q000097:blood* / Q000652:urine
chemical_list: D012459:Salicylates; C033069:methyl salicylate; D001241:Aspirin