Effects of pH and hypoglycemia on bilirubin cytotoxicity in vitro.
In this study the effects of pH and hypoglycemia on bilirubin cytotoxicity in vitro were examined by means of a 51Cr release assay. The bilirubin cytotoxicity, which was dose dependent, was increased at lower pH values. Cells, pre-exposed to the hypoglycemic state, became more resistant on incubation in culture medium containing glucose for 1 h in comparison with those exposed to the hypoglycemic state only.
D001663:Bilirubin / Q000008:administration & dosage / Q000633:toxicity*; D002478:Cells, Cultured; D002860:Chromium Radioisotopes; D005947:Glucose / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007003:Hypoglycemia / Q000150:complications; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000150:complications
D002860:Chromium Radioisotopes; D005947:Glucose; D001663:Bilirubin