The effect of isoxicam-aspirin combinations on the polyurethane sponge implantation model in the rat.
1 Anti-inflammatory effects of isoxicam alone and in combination with aspirin were studied in rats using the polyurethane sponge implantation model of acute inflammation. 2 Dose-response studies were performed to delineate a suppressive (high) and non-suppressive (low) dose of isoxicam prior to studying these doses in combination with aspirin. 3 The results indicate that a combination of aspirin with isoxicam does not have an additive anti-inflammatory effect. 4 The interference demonstrated by aspirin with the anti-inflammatory effects of other NSAIDs such as indomethacin is also demonstrated with aspirin/isoxicam combinations.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin / Q000627:therapeutic use*; D004338:Drug Combinations; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011140:Polyurethanes; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D011140:Polyurethanes; D010894:Piroxicam; C013580:isoxicam; C028279:polyurethane foam; D001241:Aspirin