Synthesis and pharmacological evaluation of thiophene analogs of lotucaine.
The syntheses of the three possible thiophene analogs of lotucaine, and of other structurally related derivatives, are described. Preliminary data on their local anesthetic as well as antiplatelet aggregation activities are given.
D000779:Anesthetics, Local / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D051379:Mice; D010974:Platelet Aggregation / Q000187:drug effects; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
D000779:Anesthetics, Local; D011759:Pyrrolidines; C003612:lotucaine