Specificity of the inhibitory effect of dextropropoxyphene on oxidative drug metabolism in man: effects on theophylline and tolbutamide disposition.
Two groups of six healthy male volunteers were studied to assess the possibility of an interaction between dextropropoxyphene and theophylline or tolbutamide using a randomised, crossover design. Subjects received theophylline 125 mg 8 hourly or tolbutamide 500 mg i.v. with and without dextropropoxyphene hydrochloride 65 mg 8 hourly. Theophylline 8-hydroxylation was reduced by a mean of 17% but there were no changes in theophylline 1-demethylation, theophylline 3-demethylation or tolbutamide hydroxylation.
D000328:Adult; D011431:Dextropropoxyphene / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D008297:Male; D010084:Oxidation-Reduction; D013806:Theophylline / Q000097:blood / Q000378:metabolism* / Q000652:urine; D014044:Tolbutamide / Q000097:blood / Q000378:metabolism*
D014044:Tolbutamide; D013806:Theophylline; D011431:Dextropropoxyphene