[Intra-individual polymorphism of human Y chromosome as a result of deletion in the heterochromatin region].
Two equal cell populations with Y-heterochromatin of different lengths were found in a sterile male with azoospermia. There was no evidence for translocation of the heterochromatic material to other chromosomes. Both cell lines have the same Q-, C- and Ag-NOR patterns of chromosomal differential staining. The Y-chromosomes of both the father and brother were as long as the longest of the two populations in the proband. This intraindividual heteromorphism of Y-chromosome is, probably, a result of Y-heterochromatin deletion during the first mitotic division of the zygote, with the loss of a fragment as long as the difference between the long and the short Y populations in the proband. Intraindividual chromosomal heteromorphism is a convenient model to study reasons for variability in the heterochromatin regions of chromosomes.
D000328:Adult; D002871:Chromosome Banding; D002872:Chromosome Deletion; D006570:Heterochromatin / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D011110:Polymorphism, Genetic; D014998:Y Chromosome
D006570:Heterochromatin
Vnutriindividual'nyĭ polimorfizm Y-khromosomy cheloveka kak sledstvie deletsii geterokhromatinovogo bloka.