Therapeutic profile of the human glioma line D-54 MG in athymic mice.
We treated D-54 MG, an extensively characterized human glioma tumor line, in athymic mice with each of 20 antineoplastic drugs and two radiation doses. PCNU, melphalan, cyclophosphamide, and fludarabine were highly active against sc tumors. A single radiation dose of 2500 cGy produced a growth delay (T-C) of 22.0 days and four of seven tumor regressions (TRs), whereas 1500 cGy produced a T-C of 13.2 days and two of 10 TRs. Several other drugs produced smaller T-Cs and fewer TRs. With this model we can make quantitative determinations of the sensitivities of a human glioma line, permitting detailed studies of drug mechanisms.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D004195:Disease Models, Animal; D005910:Glioma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D012074:Remission Induction
D000970:Antineoplastic Agents