The effect of triphasic and biphasic oral contraceptive preparations on HDL-cholesterol and LDL-cholesterol in young women.
Lipid changes were measured during two consecutive studies on efficacy, side effects, and metabolic changes of oral contraceptive (OC) preparations. The mean lipid values of women on OCs at the start of the two studies were compared to those of women who had not taken OCs for at least 3 months. It was found that LDL-cholesterol (LDL-C) mean values of the women on OCs were higher than the mean values of women who had not taken OCs for at least 3 months. In study #1, women received the OC preparation Triphasil. In study #2, women were randomised to one of 3 OC preparations (Triphasil, Ortho 777 or Ortho 10/11). HDL-cholesterol (HDL-C) and LDL-C were measured over time at six months and at 12 months after receiving the study medications. The results show that HDL-C increased in women on Ortho 777 and 10/11 and decreased in women on Triphasil at six months, and these changes were not found at 12 months. The results showed change over time for the LDL-C mean values, in that women not on OCs at the start of the studies had increased LDL-C mean values, and women on OCs at the start of the studies had decreased LDL-C mean values. Further the LDL-C mean values in women not on OCs at the start of the studies who received Triphasil (containing the gonane progestin dl-norgestrel) increased over time, whereas the combined mean values of those who received Ortho 777 and Ortho 10/11 (containing the estrane progestin norethindrone) did not increase over time.(ABSTRACT TRUNCATED AT 250 WORDS)
D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D006801:Humans; D009644:Norgestrel / Q000494:pharmacology*; D011897:Random Allocation; D012907:Smoking; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003278:Contraceptives, Oral, Hormonal; D014280:Triglycerides; D009644:Norgestrel; D004997:Ethinyl Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination