[Endothelial cell proliferation in vitro induced by sera of patients with progressive systemic sclerosis and systemic lupus erythematosus].
Endothelial cells from human umbilical cord veins proliferate in vitro up to 35-fold over control values when incubated for prolonged periods of time (up to 144 hrs) in the presence of sera from patients with SLE or PSS. The proliferation inducing capacity of patients' sera was high during remission and low during relapses. Similarly, induction of endothelial cell proliferation increased significantly following plasma separation; however, this effect did only last for a few hours. The in vitro stimulation of endothelial cells observed may be correlated to histological findings of hyperplasia and neoproliferation of vascular intima cells in SLE and PSS.
D002455:Cell Division; D004727:Endothelium / Q000166:cytology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000503:physiopathology; D009103:Multiple Sclerosis / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D012075:Remission, Spontaneous; D014470:Umbilical Cord / Q000166:cytology
Endothelzellproliferation in vitro durch Seren von Patienten mit progressiver Systemsklerose (PSS) und systemischem Lupus erythematodes (SLE).