[Medulloblastoma of the posterior cranial fossa. A second tumor after Hodgkin's disease].
The case of a child presenting with Hodgkin's disease (stage I A, mixed cellular type) at the age of 23 months is reported. Chemotherapy (six treatments with MOPP) enabled a clinical remission, but an in situ relapse with the same histological pattern was observed at the age of 3 years and 9 months. After local irradiation, a second complete remission was observed. At the age of 6, a clinical picture of intraskull hypertension with ataxia, lead to the diagnosis of posterior cavity tumor. Complete excision was performed and the pathological examination showed a typical medulloblastoma. Adjuvant radiotherapy was carried out. Eight months later, a fatal plurifocal medullar relapse was observed. Second tumors in Hodgkin's disease are well known. However, this new case appeared to be the first report of a medulloblastoma after Hodgkin's disease.
D002528:Cerebellar Neoplasms / Q000628:therapy; D003131:Combined Modality Therapy; D003388:Cranial Fossa, Posterior; D006689:Hodgkin Disease; D006801:Humans; D007223:Infant; D008297:Male; D008527:Medulloblastoma / Q000628:therapy; D009364:Neoplasm Recurrence, Local; D009378:Neoplasms, Multiple Primary; D014057:Tomography, X-Ray Computed
Médulloblastome de la fosse postérieure. Deuxième tumeur après une maladie de Hodgkin.