title: [Characteristics of 2 clinico-pathogenetic variants of the atopic form of bronchial asthma].
abstract: IgE- and IgG-reagins were investigated in the sera of 120 patients with atopic bronchial asthma. Two clinicopathogenetic variants of disease were defined with relation to the genetic variants of disease were defined with relation to the main immunological mechanism: IgE-dependent (in 78 patients) and IgE-IgG-dependent (in 42 patients). Variations in a clinical picture, the results of specific allergological examination, the level of total serum IgE in different variants of the atopic form of bronchial asthma were established. Specific immunotherapy produced a good effect in the IgE-dependent variant. In the patients with the IgE-IgG-dependent variant specific immunotherapy with a house dust allergen proved to be ineffective in most cases.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis*; D001249:Asthma / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D003937:Diagnosis, Differential; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D007073:Immunoglobulin E / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D008875:Middle Aged; D011935:Reagins / Q000032:analysis*; D012882:Skin Tests
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D011935:Reagins; D007073:Immunoglobulin E
vernacular_title: K kharakteristike dvukh kliniko-patogeneticheskikh variantov atopicheskoĭ formy bronkhial'noĭ astmy.