title: Long-term treatment of hypertension with the calcium channel blocker diltiazem.
abstract: A group of 48 patients with essential mild to moderate hypertension were treated with the calcium-channel blocker diltiazem (90-270 mg/day) for one year. Adequate blood pressure control was achieved in all patients. No tolerance developed during the one-year treatment period. The drug is almost free from side effects. Very few patients develop fluid retention, which can be controlled by adding a diuretic.
mesh_terms: D004110:Diltiazem / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008137:Longitudinal Studies
chemical_list: D004110:Diltiazem