Antibodies to normal and Alzheimer human brain structures from non-immunised mice of various ages.
Supernatants from mouse spleen hybridoma lines established without previous immunisation were screened immunohistochemically against cryostat sections of human temporal cortex and found to stain a variety of brain structures, including Alzheimer plaques and tangles. The age of the mice had no effect on antibody production.
D000367:Age Factors; D000544:Alzheimer Disease / Q000276:immunology* / Q000473:pathology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D006801:Humans; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D009454:Neurofibrils / Q000276:immunology; D013702:Temporal Lobe / Q000276:immunology* / Q000648:ultrastructure
D000911:Antibodies, Monoclonal; D000941:Antigens