[Effectiveness of antioxidants in a combined carbon tetrachloride and ethanol lesion of the liver].
Carbon tetrachloride administered together with ethanol was found in experiments on male albino rats to cause a severe liver damage. The use of unithiol, flakumin, tocopherol acetate, silymarin and silybor and also their combinations under these conditions not only decreases lipid hyperperoxidation and prevents depletion of the reduced glutathione pool but also retains a functional liver disturbance. Silybor, silymarin and tocopherol acetate in combination with flakumin proved to be the most efficient.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy / Q000378:metabolism; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D051381:Rats
D000975:Antioxidants
Effektivnost' antioksidantov pri kombinirovannom porazhenii pecheni chetyrekhkhloristym uglerodom i étanolom.