[Induced hyperglycemia as a factor of modification of sarcoma 45 sensitivity to chemotherapy].
The injection of sarcolysine, methotrexate, thiophosphamide, cyclophosphamide, adryamycin and platidinum during glucose infusion is shown to increase their antitumour activity. The antitumour effectiveness of 5-FU did not increase under conditions of artificial hyperglycemia, while that of vincristine decreased. Intensification of the activity of some chemotherapeutic drugs in combination with hyperglycemia was observed against the background of their increased general toxic effects.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001786:Blood Glucose / Q000502:physiology*; D004351:Drug Resistance; D004357:Drug Synergism; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D008297:Male; D051381:Rats; D012513:Sarcoma, Experimental / Q000097:blood / Q000188:drug therapy*
D000970:Antineoplastic Agents; D001786:Blood Glucose; D005947:Glucose
Iskusstvennaia giperglikemiia kak faktor modifikatsii chuvstvitel'nosti sarkomy 45 k khimioterapii.