Angiotensin evokes in polyploid rat glioma cells hyperpolarization-depolarization responses and cross-desensitization with bradykinin.
Angiotensins I, II and III induced a hyperpolarizing response of up to 1 min duration followed by a depolarizing response of up to 4 min when applied by pressure pulses or iontophoresis to polyploid rat glioma cells C6-4-2. The hyperpolarization (depolarization) was associated with a 50% decrease (no measurable change) in membrane resistance. The reversal potential (ca.-90 mV) of the hyperpolarization most likely points to an increase K+ conductance. Cells desensitized to angiotensins on application of high doses of either angiotensins or bradykinin.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002460:Cell Line; D004351:Drug Resistance; D004594:Electrophysiology; D005910:Glioma / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D009474:Neurons / Q000187:drug effects*; D011123:Polyploidy; D051381:Rats
D000804:Angiotensin II; D001920:Bradykinin