title: EEG, visually evoked and event related potentials in young abstinent alcoholics.
abstract: EEG, visually evoked potentials (VEP), and event related potentials (P300) were recorded from 60 males aged 25-40 (20 abstinent alcoholics, 20 social drinkers, and 20 lifetime nondrinkers). Alcoholics were at least 1 month abstinent, medication free, and neuropsychologically normal. Residual effects of alcohol abuse were not detected in EEG power and cortical coupling analyses, or VEP amplitude, latency, and amplitude/intensity slope measures. Only P300 measures, recorded while subjects were actively engaged in a visual oddball task (20% targets), differentiated alcoholics from nonalcoholics. Alcoholics had reduced N2-P3 amplitude and delayed N2 latencies compared to social drinkers and nondrinkers. Because P300 abnormalities have been reported for individuals with positive family history for alcoholism, it is not clear whether these results reflect familial influence or residual effects of alcohol abuse. Issues relating to age, health and medication status of abstinent alcoholics, and use of social drinkers as comparison groups in studies of brain dysfunction in "recovering" alcoholics are also discussed.
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000503:physiopathology*; D004569:Electroencephalography; D005074:Evoked Potentials, Visual; D006801:Humans; D008297:Male; D011597:Psychomotor Performance; D013695:Temperance