Amantadine for levodopa resistant parkinsonism.
A 65-year-old woman with stigmata of Parkinsonism was resistant to therapy with levodopa, bromocriptine and anticholinergics. However, administration of amantadine (Symmetrel), (200 mg/day) produced significant improvement in her motor disability as well as in her mental status. The mechanisms of amantadine's therapeutic effects in this unusual case are discussed.
D000368:Aged; D000547:Amantadine / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D010300:Parkinson Disease / Q000188:drug therapy*
D007980:Levodopa; D000547:Amantadine