[Long-term intracardiac electrophysiological research on patients with paroxysmal ventricular tachycardias: a prospective method for the choice and evaluation of the effectiveness of anti-arrhythmia treatment].
Fifteen patients with paroxysmal ventricular tachycardia (PVT) were subjected to prolonged intracardiac electrophysiologic investigation (EPI) combined with tests of a variety of antiarrhythmic agents. One to 4 (2 +/- 0.3) agents were found to be capable of preventing ventricular tachycardia in response to endocardial stimulation in 93.3% of cases. Subsequent antiarrhythmic treatment by a drug thus selected prevented ventricular tachycardia paroxysms in all patients: there were no recurrent paroxysms in 10 (71.4%) patients, while tachycardiac attacks grew much less frequent, as compared to the pretreatment situation, and could be easily controlled by an additional dose of the drug in 4 (28.6%). Prolonged intracardiac EPI is a highly efficient method of individual assessment of drugs' antiarrhythmic effect that allows a timely and correct choice of treatment capable of reliable prevention of paroxysms.
D000293:Adolescent; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D003937:Diagnosis, Differential; D004341:Drug Evaluation / Q000379:methods; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013614:Tachycardia, Paroxysmal / Q000175:diagnosis* / Q000188:drug therapy; D013997:Time Factors
D000889:Anti-Arrhythmia Agents
Dlitel'noe vnutriserdechnoe élektrofiziologicheskoe issledovanie u bol'nykh s paroksizmal'nymi zheludochkovymi takhikardiiami: perspektivnyĭ metod vybora i otsenki éffektivnosti antiaritmicheskogo lecheniia.