Evidence for a relationship between amphetamine sensitization and electrical kindling of the amygdala.
Several schedules of long-term amphetamine administration were evaluated on the development of kindling from the amygdala. Consistent with earlier work involving the effects of chronic exposure to stimulant drugs, withdrawal from chronic amphetamine treatment had little or no effect on kindling. Facilitation of kindling was observed, however, under several schedules of drug treatment. The synergism between amphetamine and kindling was evident during drug schedules in which animals were maintained on drug treatment during the kindling procedure. Under these conditions, the facilitating effects of repeated amphetamine treatment varied as a function of prior experience with the drug. Our findings indicate a relationship between processes involved in amphetamine sensitization and kindling. These data have implications in relation to behavioral observations involving the development of postamphetamine depression during drug withdrawal, and amphetamine sensitization after drug challenge.
D000679:Amygdala / Q000187:drug effects* / Q000503:physiopathology; D000818:Animals; D003913:Dextroamphetamine / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004558:Electric Stimulation; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003913:Dextroamphetamine