[Role of mitochondrial peroxidation of lipids in their hydrolysis by endogenous phospholipase A2].
The analysis of lipids (18 compounds all in all) obtained from mitochondria and incubated for two hours was carried out. It has been shown that hydrolysis of individual phospholipids by endogenous phospholipase of these organelles depends on the intensity of lipid peroxidation (LPO). Thus, with the low level of this process the content of phosphatidylethanolamine, cardiolipin and phosphatidylcholine decreased by 25%, 33% and 18%, respectively of the initial level. However, with LPO activation, their content reduced by 63%, 19% and 4%.
D000818:Animals; D006868:Hydrolysis; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D008930:Mitochondria, Liver / Q000201:enzymology*; D010084:Oxidation-Reduction; D010740:Phospholipases / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D008054:Lipid Peroxides; D010743:Phospholipids; D008315:Malondialdehyde; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2
Rol' perekisnogo okisleniia lipidov mitokhondriĭ v ikh gidrolize éndogennoĭ fosfolipazoĭ A2.