[Studies on the anti-tumor effect of the E2 carrier drug and its mechanism].
In this study, the anti-tumor effect of E2 carrier drug on MM2 cells transplanted to C3H/He mice and its mechanism were observed. The results were as follows. The estrogen receptor on cytosol in MM2 cell and nuclei were positively confirmed, but the progesterone receptor was not. When the effect of this drug on MM2 cells was measured by the ratio of inhibition to the growth of the tumor, the effect on the group treated with a high dose of E2 carrier drug (100mg/kg) was found to be significantly higher than found with physiological saline (p less than 0.05). The main route of action is considered to be not related to the steroid receptor but to the retention of Estramustine (EM-2), Estromustine (EM-1), and Estradiol (E2) in tumor tissues. Histomorphological findings on the MM2 cells treated with E2 carrier drug revealed nuclear pyknosis and giant cell transformation. The strength of these effects seemed to depend on the size of the dose of E2 carrier drug.
D000818:Animals; D004958:Estradiol / Q000097:blood; D004961:Estramustine / Q000032:analysis / Q000627:therapeutic use*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D009588:Nitrogen Mustard Compounds / Q000627:therapeutic use*; D011960:Receptors, Estrogen / Q000032:analysis
D009588:Nitrogen Mustard Compounds; D011960:Receptors, Estrogen; D004961:Estramustine; D004958:Estradiol