Indomethacin pretreatment inhibits fever after anodal, but not cathodal, medial preoptic lesions in rats.
Pretreatment with indomethacin (15 mg/kg) prevented the fever occurring in unanesthetized rats immediately after unilateral anodal electrolytic lesions of the medial preoptic area. The drug had no effect on the fever if given before cathodal lesions. If given after the lesions, when the fever had begun to develop, indomethacin lowered anodal body temperature back to baseline for varied lengths of time and attenuated cathodal fever.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004558:Electric Stimulation; D004566:Electrodes; D006979:Hyperthermia, Induced; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011301:Preoptic Area / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D013997:Time Factors
D007213:Indomethacin