[Morphological manifestations of anthracycline cardiomyopathy in the ventricular myocardium of the rat].
Cardiomyopathy and plastic contractile myocardial insufficiency were simulated in Wistar rats by an anthracycline antibiotic rubomycin. The myocardium in conditions of DNA-dependent RNA synthesis suppression was studied using polarization, electron microscopy and the method of cardiomyocyte isolation. During anthracycline cardiomyopathy in the absence of necrotic and necrobiotic myocardial injuries there was a smaller depression of cardiomyocyte population and their nuclei in the right ventricle (23 and 22% respectively) than in the left ventricle (38 and 39% respectively). It was concluded that a smaller amount of cardiomyocyte population was in the phase of intensive protein synthesis in the right than in the left ventricular myocardium.
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000473:pathology*; D003630:Daunorubicin / Q000633:toxicity*; D004195:Disease Models, Animal; D006352:Heart Ventricles / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008859:Microscopy, Polarization; D009206:Myocardium / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003630:Daunorubicin
Morfologicheskie proiavleniia antratsiklinovoĭ kardiomiopatii v miokarde zheludochkov serdtsa krys.