[AHH activity and life environmental factors].
To investigate life environmental factors which affect aryl hydrocarbon hydroxylase (AHH) activity, basal and 3-methylcholanthrene(3-MC)-induced AHH activities were determined by the formation of 3-hydroxybenzo(a)pyrene in cultured lymphocytes obtained from 111 healthy male subjects who lived in Fukuoka Prefecture, Japan. Fold induction (3-MC-induced/basal) was calculated. Relationship between the absolute activities and the fold induction of AHH and life environmental factors was statistically examined. Study of simple correlation indicated the following: Basal AHH activity was positively correlated with age and habitual intake of drugs. Induced AHH activity was positively correlated with coffee intake, smoking and habitual intake of drugs. Fold induction was positively correlated with coffee intake and smoking, and negatively with age. Using multiple regression analysis, habitual intake of drugs showed positive relation to both basal and induced enzyme activity, and age showed positive relation to the basal activity and negative relation to the fold induction.
D000328:Adult; D000368:Aged; D000375:Aging; D001189:Aryl Hydrocarbon Hydroxylases / Q000097:blood*; D004777:Environment; D005247:Feeding Behavior; D006801:Humans; D008019:Life Style; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D012907:Smoking
D001189:Aryl Hydrocarbon Hydroxylases