Silver-induced lipid peroxidation in mice: interactions with selenium and nickel.
Lipid peroxidation in silver-treated mice was assayed by measuring the malondialdehyde (MDA) content of liver, kidney and brain tissue. After a single intraperitoneal injection of 20 mg/kg silver lactate, lipid peroxidation was significantly increased in the liver 3, 12 and 48 h after exposure whereas MDA levels in kidney and brain were not significantly affected. Pretreatment with 2 mg/kg sodium selenite i.p. for 2 days resulted in an increase in silver-induced lipid peroxidation in the liver. Liver from mice treated with 20 mg/kg silver lactate followed by an injection of 35 micrograms/kg nickel chloride had significantly higher contents of MDA than did livers from mice treated with either silver or nickel alone, suggesting a synergism between silver and other lipid peroxidation-inducing compounds.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004357:Drug Synergism; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007773:Lactates / Q000494:pharmacology; D019344:Lactic Acid; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008314:Malonates / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism*; D051379:Mice; D009532:Nickel / Q000494:pharmacology*; D020887:Selenious Acid; D012643:Selenium / Q000494:pharmacology*; D012834:Silver / Q000494:pharmacology*
D007773:Lactates; D008054:Lipid Peroxides; D008314:Malonates; D019344:Lactic Acid; D012834:Silver; D008315:Malondialdehyde; C022838:nickel chloride; D009532:Nickel; D020887:Selenious Acid; D012643:Selenium