title: [Primary Gougerot-Sjögren syndrome with necrotizing polymyositis: favorable effect of hydroxychloroquine].
abstract: A 61-year-old woman was admitted for acute arthralgias and proximal weakness in all four limbs. Clinical examination found xerostomia, xerophthalmia, enlarged parotid glands. The Schirmer test was positive and the salivary gland biopsy showed a mononuclear, lymphoid, sometimes nodular infiltrate. A muscle biopsy showed necrotizing myopathy with perifascicular atrophy. The patient refused steroids and was given hydroxychloroquine (600 mg daily). She improved gradually, and one year later there were no further complications. The favorable course both of Sjögren's syndrome and polymyositis with hydroxychloroquine treatment is unexpected. This led us to suppose that both could have had a common cause.
mesh_terms: D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use*; D008875:Middle Aged; D009220:Myositis / Q000188:drug therapy* / Q000209:etiology; D012859:Sjogren's Syndrome / Q000150:complications / Q000188:drug therapy*
chemical_list: D006886:Hydroxychloroquine
vernacular_title: Syndrome de Gougerot-Sjögren primitif avec polymyosite necrosante: effet favorable de l'hydroxychloroquine.