Kazusamycin B, a novel antitumor antibiotic.
A novel antibiotic, kazusamycin B (C32H46O7, MW 542), was isolated from the fermentation broth of Streptomyces sp. No. 81-484 and the structure was established mainly on the basis of its physico-chemical properties. Unambiguous 13C NMR spectral analysis of kazusamycin B has been also accomplished. Kazusamycin B possesses potent cytocidal activities against L1210 (IC50 0.0018 micrograms/ml) and P388 (IC100 0.0016 micrograms/ml) leukemia cells in vitro.
D000818:Animals; D000903:Antibiotics, Antineoplastic; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D013053:Spectrophotometry; D013302:Streptomyces / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D005231:Fatty Acids, Unsaturated; C051484:PD 124895