title: [Mechanisms of the pathogenetic prevention of acute pancreatitis in an experiment].
abstract: The work was aimed at the elucidation of mechanisms of pathogenetic prevention of acute experimental pancreatitis induced according to the method of Arai. Pathological and biochemical examinations have shown that the application of PNA synthesis inhibitor 5-FU and cellular and intracellular membrane stabilizer-intralipid, infused at the beginning of the experiment, prevented the development of acute purulent pancreatitis.
mesh_terms: D000208:Acute Disease; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D008297:Male; D009336:Necrosis; D010179:Pancreas / Q000187:drug effects / Q000648:ultrastructure; D010195:Pancreatitis / Q000201:enzymology / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D013997:Time Factors
chemical_list: D005217:Fat Emulsions, Intravenous; D005472:Fluorouracil
vernacular_title: Mekhanizmy patogeneticheskoĭ profilaktiki ostrogo pankreatita v éksperimente.