Studies on liver toxicants. Mixed-function oxidase activities and hemoprotein contents in livers of rats poisoned with bromobenzene.
In liver microsomes of rats 5 h after intraperitoneal administration of bromobenzene, the activities of a series of drug-metabolizing mixed-function oxidases, i.e., ketamine and aminopyrine N-demethylases, methylayapanine and methoxybiphenyl O-demethylases, and ethoxycoumarin O-deethylase, as well as glutathione and cytochrome b5 contents were found to be decreased, whereas the activities of microsomal, NADPH-dependent cytochrome c and neotetrazolium reductases as well as cytochrome P-450 were unchanged.
D000818:Animals; D001969:Bromobenzenes / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology*; D005260:Female; D006420:Hemeproteins / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D001969:Bromobenzenes; D006420:Hemeproteins; D006899:Mixed Function Oxygenases