title: Molecular evolution of the calmodulin gene.
abstract: On the basis of the intron/exon organization and the intramolecular homology of DNA sequences, I propose a novel model for genesis of the calmodulin gene. A primordial calmodulin gene consisting of 51 base pairs (17 amino acids) was subjected to three-fold duplication to create modern calmodulin with four calcium-binding subdomains. The model elucidates the seemingly enigmatic positions of splice junctions observed in calmodulin genes.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D005075:Biological Evolution; D002147:Calmodulin / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005091:Exons; D005796:Genes; D007438:Introns; D005810:Multigene Family; D011487:Protein Conformation; D012326:RNA Splicing; D012689:Sequence Homology, Nucleic Acid
chemical_list: D002147:Calmodulin; D004247:DNA