Antibacterial and antitumor activity of platinum complexes of hydrazinopyrimidines and amidrazones.
Antibacterial and antitumor activity of 10 platinum complexes of N3-phenylsubstituted amidrazones and hydrazinopyrimidines has been studied. It has been found that the platinum complexes of amidrazones, containing substituents in the benzene nuclear or in the NH2-group, exhibit a better antibacterial activity while those without substituents in their benzene nuclears have a pronounced antibacterial activity mostly on bacterial test-systems used in the prescreening of antitumor agents (S. lutea and UV-2). Most of the studid platinum complexes of hydrazinopyrimidines show inhibitory effect on the bacterial strains used in the prescreening of antitumor agents. The antitumor activity of platinum complexes has been tested on L1210 leukemia, adenocarcinoma 755 and Lewis carcinoma. An inhibitory effect is observed in the case of adenocarcinoma 755 with the cis-isomer of the platinum complex of N3-p-tolylbenzamidrazone (the tumor growth was 60% suppressed).
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D011725:Pyridines; D011743:Pyrimidines