[Physicochemical properties of the diabetogenic factor and its complex with heparin].
The diabetogenic factor (DGF) isolated from the human blood and the blood of rats with diabetes mellitus was shown to be a protein homogeneous at electrophoresis in gel of polyacrylamide, with the molecular weight of 60,000 D. The interaction of DGF with heparin results in the formation of a complex in which the factor's properties are blocked and those of heparin as a anticoagulant are preserved.
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003920:Diabetes Mellitus / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004591:Electrophoresis, Polyacrylamide Gel; D006493:Heparin / Q000032:analysis*; D006801:Humans; D010907:Pituitary Hormones / Q000032:analysis* / Q000302:isolation & purification; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
C488867:DGF protein, rat; D010907:Pituitary Hormones; C010912:diabetogenic factor, human; D006493:Heparin
Nekotorye fiziko-khimicheskie svoĭstva diabetogennogo faktora i ego kompleksa s geparinom.