title: Accommodation of an endocapsular silicone lens (Phaco-Ersatz) in the nonhuman primate.
abstract: In owl monkeys, as a model of endocapsular cataract extraction, the lens material was removed through a small hole in the capsule and was replaced with a silicone polymeric gel. The ability of this endocapsular implant (Phaco-Ersatz) to accommodate was documented when pilocarpine produced an increase in the curvature of the lens surface and a decrease in the anterior chamber depth, just as occurs with the untouched natural lens. Refinements of the surgical technique are required to achieve a controlled degree of filling of the capsular bag and inhibit postoperative epithelial proliferation on the inner capsular surface.
mesh_terms: D000065:Accommodation, Ocular; D000818:Animals; D000867:Anterior Chamber / Q000033:anatomy & histology; D001029:Aotus trivirgatus; D002387:Cataract Extraction / Q000379:methods; D002924:Ciliary Body / Q000187:drug effects; D007910:Lenses, Intraocular; D010862:Pilocarpine / Q000494:pharmacology; D011817:Rabbits; D012029:Refraction, Ocular; D012828:Silicones
chemical_list: D012828:Silicones; D010862:Pilocarpine