Incidence of cancer in 98 patients with common varied immunodeficiency.
Ninety-eight patients with common varied immunodeficiency have been observed for periods of 1-13 years. In 1986, 78 were alive, 19 had died, and 1 could not be located. Eleven patients in the group had developed cancer; two patients had had two cancers. Of the total number of neoplastic malignancies, seven were non-Hodgkin's lymphoma, one patient had a Waldenstrom's macroglobulinemia, and nine of the patients who developed cancer were female. Cancer developed in the fifth or sixth decade of life for 10 of the 11 patients. These data show an 8- to 13-fold increase in cancer in general for patients who have this immunodeficiency and a 438-fold increase in lymphoma for females.
D000361:Agammaglobulinemia / Q000150:complications* / Q000276:immunology; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008223:Lymphoma / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology*; D009378:Neoplasms, Multiple Primary / Q000209:etiology; D012306:Risk; D013997:Time Factors