title: Effect of i.v. lignocaine on pain and the endocrine metabolic responses after surgery.
abstract: Pain intensity, and blood glucose and plasma cortisol concentrations were measured following abdominal hysterectomy in 18 patients allocated randomly to receive either i.v. lignocaine 1.5 mg kg-1 plus 2 mg kg-1 h-1, or saline. The administration of lignocaine resulted in plasma concentrations between 1.5 and 2.0 micrograms ml-1 during the 2-h study period. However, the administration of lignocaine i.v. had no effect on the intensity of pain after surgery, or on the adrenocortical and hyperglycaemic responses to surgery.
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007044:Hysterectomy; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*
chemical_list: D001786:Blood Glucose; D008012:Lidocaine; D006854:Hydrocortisone