Effect of ionizing radiation on the content of receptors to Fc-fragments of immunoglobulins in peritoneal macrophages of mice.
It has been demonstrated in experiments on 500 F1 (CBS X C57B1) mice that irradiation with 137Cs gamma rays in doses of 700--800 R (6.72--7.68 Gy) provokes initially a slight increase and subsequently progressive decrease in the number of cells with FcR among peritoneal mononuclears of mice, reaching its maximum on day 20 and persisting until the end of the month. Subcutaneous single injection of syngenic serum immunoglobulins in a dose of 10 mg protein per mouse (500 mg/kg) helps to preserve the number of mononuclears with FcR at a level higher than in intact animals, showing a significant increase on days 1, 5, 10 and 25. This phenomenon is more pronounced after administration of immunoglobulins with normal antibodies to tissues obtained by precipitation with ammonium sulphate from the serum of hemostimulated mice.
D000818:Animals; D005260:Female; D005720:Gamma Rays; D007136:Immunoglobulins / Q000502:physiology*; D008264:Macrophages / Q000276:immunology* / Q000528:radiation effects; D051379:Mice; D011961:Receptors, Fc / Q000528:radiation effects*
D007136:Immunoglobulins; D011961:Receptors, Fc