Comparison of N-acetyl-beta-glucosaminidase and albuminuria with clinical finding of microangiopathy in type I diabetes mellitus.
N-acetyl-beta-Glucosaminidase activity in serum and urine and microalbuminuria were measured in 70 type-I diabetics and compared with glycated serum protein as well as with the finding of diabetic retinopathy. A significantly increased N-acetyl-beta-glucosaminidase activity in serum correlated positively with glycated protein but not with the development of retinopathy. Urinary N-acetyl-beta-glucosaminidase activity and albuminuria were significantly increased in diabetics with (p less than 0.001) or without (p less than 0.01) retinopathy as compared to healthy controls. A significant positive correlation was observed between urinary N-acetyl-beta-glucosaminidase activity and albuminuria (r = 0.73, p less than 0.01) as well as between blood pressure and albuminuria (r = 0.51, p less than 0.05).
D000118:Acetylglucosaminidase / Q000378:metabolism*; D000328:Adult; D000419:Albuminuria / Q000150:complications* / Q000201:enzymology / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000201:enzymology* / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000150:complications* / Q000201:enzymology / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000150:complications / Q000175:diagnosis; D003930:Diabetic Retinopathy / Q000150:complications / Q000201:enzymology / Q000378:metabolism; D006596:Hexosaminidases / Q000378:metabolism*; D006801:Humans
D001798:Blood Proteins; D006596:Hexosaminidases; D000118:Acetylglucosaminidase