title: The pathogenesis of benzimidazole-resistant and benzimidazole-susceptible strains of Trichostrongylus colubriformis in the Mongolian gerbil (Meriones unguiculatus).
abstract: Mongolian gerbils were infected with either a benzimidazole-susceptible or a benzimidazole-resistant strain of Trichostrongylus colubriformis larvae. The comparative pathogenesis of both strains of T. colubriformis was investigated for 50 days post-infection. The gerbils infected with the drug-susceptible strain of the parasite showed lower survival rates, reduced body weights, higher parasite egg output and higher worm burdens than animals infected with the drug-resistant strain of parasite. There was also evidence of an enhanced hypoalbuminaemia and a more marked gastrointestinal plasma leak in the gerbils infected with the drug-susceptible strain of parasite. Scanning electron microscope examination of the small intestine showed signs of villus atrophy in both groups of infected gerbils.
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D004351:Drug Resistance; D005243:Feces / Q000469:parasitology; D005260:Female; D005849:Gerbillinae; D007411:Intestinal Diseases, Parasitic / Q000469:parasitology* / Q000473:pathology; D007421:Intestine, Small / Q000469:parasitology / Q000648:ultrastructure; D008297:Male; D008855:Microscopy, Electron, Scanning; D010270:Parasite Egg Count; D014252:Trichostrongyloidiasis / Q000469:parasitology*; D014253:Trichostrongylosis / Q000469:parasitology* / Q000473:pathology; D014254:Trichostrongylus / Q000187:drug effects* / Q000502:physiology
chemical_list: D001562:Benzimidazoles