title: Hibiclens keratitis.
abstract: Presumed accidental corneal exposure to Hibiclens (chlorhexidine 4% and detergent) in two patients resulted in severe and permanent corneal opacification. We investigated the corneal toxicity of Hibiclens by gross, biomicroscopic, and histopathologic studies of rabbit eyes exposed to Hibiclens for varying time intervals ranging from five to 15 minutes. Severe, irreversible, and progressive corneal damage resulted in all eyes studied.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002710:Chlorhexidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D003318:Corneal Opacity / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007634:Keratitis / Q000139:chemically induced* / Q000473:pathology; D011817:Rabbits
chemical_list: C010882:chlorhexidine gluconate; D002710:Chlorhexidine