Transfer of the heritable nonhemolytic jaundice trait from the Gunn rat to the Sprague-Dawley rat.
Congenital nonhemolytic jaundice as observed in the Gunn rat was transferred successfully to the Sprague-Dawley rat. This jaundice trait occurs as the result of a deficiency of bilirubin glucuronyltransferase and appeared to transfer by simple Mendelian inheritance. A comparison of jaundiced Gunn with jaundiced Gunn-Sprague-Dawley cross rats for plasma bilirubin level, bilirubin glucuronyltransferase activity and female reproductive performance showed no significant difference between the two jaundiced rat groups. The phenotypic expression of the jaundice trait as viewed by the parameters used in this study appeared to be the same for both the Gunn and Gunn-Sprague-Dawley cross rats. The transfer of the jaundice trait to another rat strain enhances the opportunity to characterize this animal model and to determine the possible influence of a long-term closed mating system.
D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D007565:Jaundice / Q000235:genetics / Q000662:veterinary*; D008297:Male; D051381:Rats; D011911:Rats, Gunn / Q000235:genetics*; D011919:Rats, Inbred Strains / Q000235:genetics*; D011922:Rats, Mutant Strains / Q000235:genetics*