title: Long-term prognosis in addiction on sedative and hypnotic drugs analyzed with the Cox regression model.
abstract: The prognosis of 221 patients first admitted in 1941-1954 for dependence on sedative-hypnotic drugs was determined in a record-linkage and interview study concluded in 1984. Different outcomes were related to admission characteristics by means of the Cox proportional hazards regression model. An excess of unnatural deaths was noted; suicides in 11% of the men and 23% of the women. Of those with primary sedative-hypnotic dependence, 46% continued to abuse drugs till death or follow-up, and of those with a primary or concomitant alcohol abuse 72%. An unfavorable outcome was significantly related to primary psychiatric symptoms before the first admission, concomitant alcohol abuse, familial drug and alcohol abuse and health care occupation.
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012044:Regression Analysis; D019966:Substance-Related Disorders / Q000150:complications / Q000401:mortality / Q000523:psychology*; D013405:Suicide / Q000453:epidemiology; D013548:Sweden
chemical_list: D006993:Hypnotics and Sedatives