[Different effects of diclofenac and ketoprofen on the bactericidal action of polynuclear neutrophils in rheumatoid polyarthritis].
The bactericidal action of neutrophil polynuclear cells (NP) is significantly lower in the presence of diclofenac than in the presence of ketoprofen in patients with rheumatoid polyarthritis. This effect perhaps takes place through a serum factor, since the bactericidal action of normal NPs is diminished when the cells are incubated in the serum of patients treated with diclofenac or in the serum of healthy individuals after ingestion of diclofenac, but it is not decreased when the cells are incubated in the serum of patients treated with ketoprofen or the serum of healthy volunteers after ingestion of ketoprofen.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D001770:Blood Bactericidal Activity / Q000187:drug effects*; D004008:Diclofenac / Q000627:therapeutic use*; D006801:Humans; D007660:Ketoprofen / Q000627:therapeutic use*; D009504:Neutrophils / Q000187:drug effects*; D010666:Phenylpropionates / Q000627:therapeutic use*
D010666:Phenylpropionates; D004008:Diclofenac; D007660:Ketoprofen
Effets différents du diclofénac et du kétoprofène sur la bactéricidie des polynucléaires neutrophiles au cours de la polyarthrite rhumatoïde.