Bursting pressure of experimental aneurysms.
The laser-sealed arteriotomy (LSA) technique was used to create experimental aneurysms in the rat carotid artery. Animals were reexplored 2, 4, and 8 weeks following LSA, at which time the aneurysms were measured and subjected to a bursting strength pressure. In addition, a group of hypertensive rats with LSA was also tested 2 weeks after surgery. The LSA procedure produced aneurysms of a stable size and bursting pressure over the time studied. The bursting pressure technique may be applicable for assessing aneurysm therapy in an experimental setting.
D000818:Animals; D001794:Blood Pressure; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D002532:Intracranial Aneurysm / Q000150:complications / Q000503:physiopathology*; D007834:Lasers; D051381:Rats; D011919:Rats, Inbred Strains; D012422:Rupture, Spontaneous