Gastric epithelial restitution at low luminal pH during influence of pentagastrin or cimetidine in the cat.
This study examines restitution of the gastric surface epithelium at luminal pH 1 after damage to the gastric mucosa by instillation of 2 M NaCl for 10 min. After mucosal damage, potential difference decreased to zero and H+ back-diffusion increased. Gastric blood flow increased after exposure to 2 M NaCl, irrespective of the secretory state of mucosa. Neither pentagastrin nor cimetidine showed any protective effect against mucosal damage produced by 2 M NaCl. Ninety minutes after mucosal exposure to 2 M NaCl there was an almost complete restitution of the gastric surface epithelium in pentagastrin-stimulated and cimetidine-treated animals, whereas about 15% of the gastric surface still showed damage in animals in which acid secretion was not interfered with. These findings show that restitution of the surface epithelium, in vivo, is a rapid and resistant process even at a very low luminal pH. The secretory state of mucosa may have some influence on this process.
D000818:Animals; D002415:Cats; D002927:Cimetidine / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D006439:Hemodynamics; D006863:Hydrogen-Ion Concentration; D008297:Male; D008564:Membrane Potentials; D010418:Pentagastrin / Q000494:pharmacology*; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D013223:Statistics as Topic; D013276:Stomach Ulcer / Q000517:prevention & control*
D012462:Saline Solution, Hypertonic; D002927:Cimetidine; D010418:Pentagastrin