[Effect of adaptation to physical loading on the adrenoreactivity of the isolated rat atrium].
The experiments on the isolated atria of rats, previously adapted to swimming exercises, have established a significant decrease in the heart rate and an increase in positive inotropic effect of noradrenaline (4 X 10(-7) and 6 X 10(-7) M). After beta-adrenoceptor blockade with propranolol (2 X 10(-6) M) the inotropic effect of an alpha-adrenoceptor agonist mezaton on the isolated atrium of the adapted rats was greater than in nonadapted controls.
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D016275:Atrial Function; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D005082:Physical Exertion / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*
D011941:Receptors, Adrenergic; D010656:Phenylephrine; D011433:Propranolol; D009638:Norepinephrine; D010646:Phentolamine
Vliianie adaptatsii k fizicheskim nagruzkam na adrenoreaktivnost' izolirovannogo predserdiia krysy.