Atrial fibrillation in a pregnant mare: treatment with quinidine sulfate.
Atrial fibrillation in a pregnant, lactating, 15-year-old mare nursing a 70-day-old foal was converted to normal sinus rhythm, using quinidine sulfate. The maximum concentration of quinidine was 4.3 mg/L in the mare's milk and was 2.6 mg/L in the mare's serum. Treatment with quinidine did not interrupt the pregnancy. Six months after treatment, the mare developed acute volvulus of the large colon and died. At necropsy, the mare did not have macroscopic or microscopic cardiac lesions. The fetus was macroscopically and histologically normal.
D000818:Animals; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D008892:Milk / Q000032:analysis; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy / Q000662:veterinary*; D011802:Quinidine / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*
D011802:Quinidine