[Analysis of the choline-sensitizing action of haloperidol on mollusk neurons].
It was shown on identified neurons of freshwater mollusk Lymnaea stagnalis that depending on the concentration haloperidol enhanced chlorine-induced depolarizing effect of carbacholine. A shift of the concentration-effect curve for carbacholine against the background of the neuroleptic action to the left on the axis of abscissae with the preservation of its maximum indicates the allosteric interaction of haloperidol with that part of the choline receptor structure which is territorially isolated from its recognizing centre.
D000494:Allosteric Regulation / Q000187:drug effects; D000818:Animals; D002794:Choline / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology*; D008195:Lymnaea; D009474:Neurons / Q000187:drug effects*; D011950:Receptors, Cholinergic / Q000187:drug effects
D011950:Receptors, Cholinergic; D006220:Haloperidol; D002794:Choline
Analiz kholinsensibiliziruiushchego deĭstviia galoperidola na neĭrony molliuska.