Effect of long-term administration of manganese on biogenic amine levels in discrete striatal regions of rat brain.
The effect of long-term manganese exposure of rats on biogenic amine levels in striatal brain regions is described. Four groups of male Sprague-Dawley rats received manganese as MnCl2 continuously in the drinking water for 60, 100, 165 and 265 days, respectively. Discrete regions within the caudate-putamen were punched out. Dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, serotonin and 5-hydroxyindoleacetic acid were determined by high performance liquid chromatography with electrochemical detection. Rats exposed for 60 and 165 days showed significantly increased levels of dopamine and 3,4-dihydroxyphenylacetic acid in discrete regions of the dorsal caudate-putamen. The affected regions were possibly not identical in the two age groups but they were adjacently situated. These alterations were not found in rats exposed for 100 or 265 days.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D020149:Manganese Poisoning; D011699:Putamen / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001679:Biogenic Amines