[The effect of nimodipine on topical distribution of absolute alpha-power in the EEG and the concurrent state of wellbeing in healthy subjects].
A double-blind cross-over comparison between the calcium antagonist nimodipine (Nimotop) and placebo with a group of 14 young, healthy volunteers showed the following: The effect of nimodipine on the EEG consists of changes in the anterior-posterior relations of absolute alpha-power which are considered to be an indicator of the vigilance level. This effect can only be demonstrated when the individual baseline (placebo-EEG) is taken into consideration. The group has been dichotomized into half-groups with higher and lower levels of vigilance. The half-group with higher levels of vigilance (n = 7) showed a decrease, the half-group with lower levels of vigilance (n = 7) showed an increase of vigilance under nimodipine. The decrease of the vigilance level was accompanied by an improvement of self-rated well-being, the increase with a deterioration. These results support earlier findings according to which nimodipine interindividually effects a stabilization of vigilance at a medium level.
D000328:Adult; D000513:Alpha Rhythm; D001143:Arousal / Q000187:drug effects; D004311:Double-Blind Method; D004644:Emotions / Q000187:drug effects*; D005143:Eyelids / Q000502:physiology; D006801:Humans; D008297:Male; D009553:Nimodipine / Q000494:pharmacology*; D011897:Random Allocation
D009553:Nimodipine
Zur Wirkung von Nimodipin auf die topische Verteilung der absoluten Alpha-Leistung im EEG sowie die aktuelle Befindlichkeit gesunder Probanden.