Effect of thiamine on the excretion of subcutaneously injected lead in rats.
The effect of thiamine on the excretion of lead in feces was investigated using rats injected subcutaneously with lead acetate and thiamine pyrophosphate. The amount of lead excreted increased with the amounts of thiamine administered, while lead concentrations in blood, liver and femur also increased. The amount of lead excreted in feces decreased, however, with administration of oxythiamine and vanadium. These results suggest that excretion of lead in feces is enhanced by thiamine and that it promotes evacuation of lead from the body.
D000818:Animals; D001835:Body Weight; D001842:Bone and Bones / Q000378:metabolism; D005243:Feces / Q000378:metabolism; D007279:Injections, Subcutaneous; D008099:Liver / Q000378:metabolism; D008297:Male; D009942:Organometallic Compounds / Q000378:metabolism*; D010119:Oxythiamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013831:Thiamine / Q000494:pharmacology*; D014639:Vanadium / Q000494:pharmacology
D009942:Organometallic Compounds; D014639:Vanadium; D010119:Oxythiamine; C008261:lead acetate; D013831:Thiamine