Localization of cholecystokinin receptors in relation to the nigrostriatal and mesolimbic dopaminergic pathways.
The anatomical distribution of cholecystokinin (CCK)-dopamine (DA) neurons suggests that CCK could modulate dopaminergic activity. To further investigate that hypothesis, the cellular localization of CCK receptors was ascertained in relation to mesolimbic and nigrostriatal DA pathways after a series of chemical lesions induced with ibotenic acid and 6-hydroxydopamine. The results suggest that CCK receptors are not localized on dopaminergic neurons of the nigrostriatal and mesolimbic pathways.
D000818:Animals; D003342:Corpus Striatum / Q000166:cytology / Q000378:metabolism*; D004298:Dopamine / Q000502:physiology*; D008032:Limbic System / Q000166:cytology / Q000378:metabolism*; D008297:Male; D009434:Neural Pathways / Q000166:cytology / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011949:Receptors, Cholecystokinin / Q000378:metabolism*; D013378:Substantia Nigra / Q000166:cytology / Q000378:metabolism*
D011949:Receptors, Cholecystokinin; D004298:Dopamine