Metoclopramide as prophylaxis for nausea and vomiting induced by fluorescein.
Fluorescein angiography carries with it a variable incidence of nausea and vomiting. We investigated a method of prophylaxis against this side effect. One hundred patients undergoing fluorescein angiography were pretreated in a double-masked, randomized fashion with either 20 mg of intravenous metoclopramide hydrochloride or an equal volume of normal saline solution. The metoclopramide-treated group demonstrated a statistically significant decrease in the incidence of nausea and vomiting. Eleven (22%) of the control group and three (6%) of the metoclopramide-treated group had this complication. Metoclopramide is an effective drug when used prophylactically in selected patients undergoing fluorescein angiography.
D005260:Female; D005451:Fluorescein Angiography / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009325:Nausea / Q000209:etiology / Q000517:prevention & control*; D014839:Vomiting / Q000209:etiology / Q000517:prevention & control*
D008787:Metoclopramide