Glutamic acid decarboxylase activity in discrete hypothalamic nuclei during the development of rats.
We have assessed the activity (nmol/mg protein/h) of glutamic acid decarboxylase (GAD) in discrete hypothalamic nuclei before and after sexual maturation in the developing female rat. Activity in other brain regions including the cortex, septum and caudate-putamen was also assessed. While there appears to be a general rise (approximately 30%), with age, in GAD activity, the rise is most marked, and highly significant (P less than 0.001), in the anterior portion of the hypothalamus (56%). In contrast, no significant increase of GAD activity was found in the medical basal hypothalamus.
D000818:Animals; D002421:Caudate Nucleus / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology; D005260:Female; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D007031:Hypothalamus / Q000201:enzymology* / Q000254:growth & development; D011699:Putamen / Q000201:enzymology; D051381:Rats; D012688:Septum Pellucidum / Q000201:enzymology
D005968:Glutamate Decarboxylase