title: Fetal brain transplants induce recuperation of taste aversion learning.
abstract: Rats showing disrupted taste aversion due to gustatory neocortex or amygdala lesions were transplanted into the lesioned area with homologous brain tissue obtained from 17-day-old fetuses. Comparisons of taste aversions scores before and after the graft, revealed that the grafted animals significantly recuperated taste aversions, whereas cortical lesioned animals without grafts did not. Surprisingly, however, amygdala-lesioned animals without graft presented spontaneous recovery. These results not only support the hypothesis that fetal brain transplants can restore cognitive functions, but also that there are some fundamental functional differences between the gustatory neocortex and the amygdala in the regulation of the processes involved in the acquisition and retention of taste aversion.
mesh_terms: D000679:Amygdala / Q000196:embryology / Q000502:physiology / Q000637:transplantation*; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D002540:Cerebral Cortex / Q000196:embryology / Q000502:physiology / Q000637:transplantation*; D003214:Conditioning, Classical / Q000502:physiology; D005333:Fetus; D006735:Horseradish Peroxidase; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009473:Neuronal Plasticity; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000502:physiology*
chemical_list: D006735:Horseradish Peroxidase