Adverse effect of 1,25-dihydroxycholecalciferol on erythrocyte precursors in the rat.
Administration of 1,25-dihydroxycholecalciferol (0.5 microgram/d/100 g body weight) to vitamin D repleted rats produced a significant decrease in the number of femoral marrow cells, specially in the erythroid line. Analysis of blood revealed slight anemia with reticulocytopenia. The survival time of 51-Cr-labelled red cells was unaffected by treatment, suggesting that bone marrow became unable to replace cells at a normal rate. The adverse effect on erythropoiesis appeared related to the degree of the concurrent hypercalcemia, which in turn depends upon the calcium content of the diet.
D000740:Anemia / Q000139:chemically induced; D000818:Animals; D001854:Bone Marrow Cells; D002117:Calcitriol / Q000008:administration & dosage / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D004032:Diet; D004920:Erythropoiesis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012156:Reticulocytes / Q000032:analysis*
D002117:Calcitriol; D002118:Calcium