Relative contribution of cysteine and methionine to glutathione content and thyroid hormone levels in the rat.
1. For a period of 24 d rats were given diets containing either casein or pea (Pisum sativum) protein at two different concentrations (180 and 120 g/kg) without or with cysteine or cysteine + methionine supplementation. 2. The effects of these diets on levels of blood and liver reduced glutathione (GSH) and serum thyroid hormones were studied. 3. When compared with the 180 g casein/kg diet, the 120 g casein/kg diet decreased liver GSH and serum thyroid hormone concentrations. These changes were related to dietary cysteine supply since supplementation induced an increase in these variables. 4. When compared with 180 g pea protein/kg diet, the 120 g pea protein/kg diet decreased liver GSH and serum thyroid hormone concentrations. These changes could not be corrected by cysteine or cysteine + methionine supplementation.
D000818:Animals; D002364:Caseins / Q000008:administration & dosage; D003545:Cysteine / Q000008:administration & dosage*; D004032:Diet; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008715:Methionine / Q000008:administration & dosage*; D009752:Nutritional Status; D051381:Rats; D011919:Rats, Inbred Strains; D013963:Thyroid Hormones / Q000097:blood*
D002364:Caseins; D013963:Thyroid Hormones; D008715:Methionine; D005978:Glutathione; D003545:Cysteine