Effect of food deprivation on survival after hemorrhage in the rat.
The changes in plasma glucose concentration and hematocrit during, and 7-day survival after, 60-min hemorrhagic hypotension (55 mmHg MAP) were investigated in postprandial and 6- or 24-h food-deprived rats. During hemorrhage, postprandial rats developed hyperglycemia, 30% greater than 6-h and 150% higher than 24-h food-deprived rats. Blood loss and plasma refill were greater in postprandial rats compared to 24-h food-deprived rats. Food deprivation for 24 h resulted in significantly increased mortality (6/13) posthemorrhage. All postprandial rats survived (13/13). A further three groups of animals deprived of food for 24 h were submitted to hemorrhage volume similar to that of postprandial rats. When no infusion was given during hemorrhage all rats died after hemorrhage (10/10). Saline infusion did not increase survival. Infusion of a similar volume of hypertonic glucose resulted in improved survival (not significant vs postprandial). Short-term food deprivation alters responses to stress and influences the outcome after standardized hemorrhage. Induction of hyperglycemia during hemorrhage was associated with survival.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005508:Food Deprivation / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006400:Hematocrit; D006470:Hemorrhage / Q000378:metabolism / Q000503:physiopathology*; D007022:Hypotension / Q000503:physiopathology; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D005947:Glucose