title: Micronucleus formation induced in rat liver and esophagus by nitrosamines.
abstract: The rat hepatocarcinogen nitrosodimethylamine and the esophageal carcinogens nitrosomethylbenzylamine and nitrosomethylamylamine were shown to produce chromosomal damage, as manifested by micronucleus formation, in their target tissues. There was cross-reactivity in the two tissues, however, at high dose levels. Nitrosodiethylamine, which produces tumors in both the liver and esophagus in the rat, also produced micronuclei in both tissues.
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects; D002869:Chromosome Aberrations; D004052:Diethylnitrosamine / Q000633:toxicity; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives / Q000633:toxicity; D004947:Esophagus / Q000187:drug effects* / Q000648:ultrastructure; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009602:Nitrosamines / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009153:Mutagens; D009602:Nitrosamines; D004052:Diethylnitrosamine; C014707:nitrosobenzylmethylamine; D004128:Dimethylnitrosamine