Kidney function in rats with corticomedullary nephrocalcinosis: effects of alterations in dietary calcium and magnesium.
Single-nephron and whole-kidney function were studied in female rats with corticomedullary nephrocalcinosis, and in animals where the lesion had been prevented either by a dietary magnesium supplement or by using a diet with a calcium:phosphorus ratio in excess of 1. At the single-nephron level, rats with nephrocalcinosis had prolonged tubular fluid transit times. Proximal transit time was 19.42 +/- 1.98 (mean +/- S.E. of mean) vs. 11.58 +/- 0.19 s for controls; distal transit time was 62.64 +/- 9.16 vs. 31.50 +/- 1.03 s for controls. Although single-nephron function is altered in nephrocalcinosis, data obtained from rats in metabolism cages indicate that whole-kidney function is largely unaffected by the lesion.
D000818:Animals; D002136:Calcium, Dietary / Q000627:therapeutic use*; D004032:Diet; D005260:Female; D007668:Kidney / Q000473:pathology / Q000503:physiopathology*; D008274:Magnesium / Q000008:administration & dosage*; D009397:Nephrocalcinosis / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control; D009399:Nephrons / Q000503:physiopathology; D010758:Phosphorus / Q000627:therapeutic use; D051381:Rats
D002136:Calcium, Dietary; D010758:Phosphorus; D008274:Magnesium