Tissue-specific expression and structure of a divergent member of a class I MHC gene family.
The class I gene family of the major histocompatibility complex (MHC) of the miniature swine (SLA) contains seven members. Six of these are highly homologous, whereas the seventh, PD6, is only distantly related. A genomic clone containing PD6 has been isolated and characterized. The PD6 SLA gene, although only 55% homologous to the other SLA class I sequences, is still a member of the family; its size and exon/intron organization are similar to other class I genes. When aligned with other SLA genes, exons 1 to 6 of PD6 have open reading frames; exon 7 contains a termination codon. PD6 is transcribed in transfected mouse L cells where its expression is enhanced by interferon. In vivo expression of PD6 is observed in a variety of tissues, with the highest levels in mature lymphoid tissues. Peripheral T cells contain high levels of PD6-specific RNA relative to B cells, whereas no PD6 transcripts are detectable in thymocytes.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D005796:Genes; D006649:Histocompatibility Antigens / Q000235:genetics*; D008214:Lymphocytes / Q000502:physiology; D008285:Major Histocompatibility Complex; D012689:Sequence Homology, Nucleic Acid; D013552:Swine / Q000235:genetics* / Q000276:immunology; D014018:Tissue Distribution
D006649:Histocompatibility Antigens