Isoxicam vs ketoprofen in ankylosing spondylitis.
1 Isoxicam, 200 mg once daily, was compared to ketoprofen, 100 mg three times daily, in 19 patients (16 males, three females) with ankylosing spondylitis in a 30-day, double-blind study conducted in two centres. 2 Improvements from baseline to final assessment were noted after both isoxicam and ketoprofen in most clinical variables, with isoxicam, in general, being more effective than ketoprofen. 3 Isoxicam was significantly superior to ketoprofen in reducing pain and was judged by both patients and physicians to be superior overall to ketoprofen. 4 Of the 13 patients who expressed a preference, 10 preferred isoxicam. 5 Typical NSAID side effects were encountered with both drugs.
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010666:Phenylpropionates / Q000627:therapeutic use*; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011897:Random Allocation; D012890:Sleep / Q000187:drug effects; D013167:Spondylitis, Ankylosing / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates; D010894:Piroxicam; C013580:isoxicam; D007660:Ketoprofen