[Stimulating effect of cocaine in rats with different levels of blood esterase activity].
It was shown in experiments on male random-bred rats that motor stimulating effect of cocaine (10 mg/kg, intraperitoneally) was dependent on the spectrum of blood serum esterase activity. The determination of esterase spectrum was performed by disc-electrophoresis in 7.5% PAAG (50-75 gamma of protein per gel), with enzyme activity estimated using alpha-naphthylacetate. Proserine (10(-5) M) and butyrylthiocholine controls were used. Motor stimulating effect of cocaine in animals with 3 esterase fractions was 3 times higher than in animals with 4 enzyme fractions.
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004589:Electrophoresis, Disc; D004950:Esterases / Q000097:blood*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D013268:Stimulation, Chemical
D004950:Esterases; D003042:Cocaine
Stimuliruiushchiĭ éffekt kokaina u krys s razlichnym spektrom ésteraznoĭ aktivnosti syvorotki krovi.