Results of peroxisome induction studies on tri(2-ethylhexyl)trimellitate and 2-ethylhexanol.
The results of these studies demonstrate that Tri(2-ethylhexyl)trimellitate (TOTM) produces the sam spectrum of morphological and biochemical changes in the rat liver as di(2-ethylhexyl)phthalate (DEHP). TOTM, however, was much less potent in its action, with a dietary level of 2.0%, causing less peroxisome proliferation and enzyme induction than 0.67% DEHP. Also, these studies show that the level of peroxisome induction in rats given TOTM is less than in those receiving a metabolically equivalent dose of 2-ethylhexanol (2-EH). Furthermore, on a molar basis, effects were lower than with DEHP. A "monoester effect" of the kind attributed to MEHP, a metabolite of DEHP, was not seen with TOTM.
D000818:Animals; D001565:Benzoates / Q000633:toxicity; D004051:Diethylhexyl Phthalate / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005260:Female; D000441:Hexanols / Q000633:toxicity*; D008099:Liver / Q000187:drug effects; D008297:Male; D008830:Microbodies / Q000187:drug effects*; D010968:Plasticizers / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D012737:Sex Factors
D001565:Benzoates; D000441:Hexanols; D010968:Plasticizers; C036101:tri-(2-ethylhexyl)trimellitate; D004051:Diethylhexyl Phthalate; C034017:2-ethylhexanol