title: Extracellular products of Staphylococcus aureus reversibly inhibit the terminal differentiation of cultured mouse epidermal cells.
abstract: The effect of extracellular products from Staphylococcus aureus on the differentiation of mouse epidermal cells was studied using an in vitro cell culture system. The extracellular products from a clinical strain of S. aureus isolated from human skin lesions reversibly inhibited the Ca++-induced terminal differentiation of epidermal cells, as determined by their morphology and the extent of cornified envelope formation. This suggests that a similar modification of cell differentiation is involved in the pathogenesis of S. aureus-induced skin disease.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001427:Bacterial Toxins / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D007169:Impetigo / Q000382:microbiology; D051379:Mice; D012867:Skin / Q000166:cytology*; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000502:physiology*
chemical_list: D001427:Bacterial Toxins; D002118:Calcium