[Reproduction study of rokitamycin. Teratological study in rabbits].
A teratological study was performed on rokitamycin (TMS-19-Q), a new macrolide antibiotic, using rabbits. TMS-19-Q, at dose levels of 100, 300 and 600 mg/kg, was orally administered from the day 6 to the day 18 of gestation to dams. Diarrhea and decrease in body weight gain and food consumption were observed in dams at or above 300 mg/kg. Decrease in numbers of live fetuses was observed at dose levels of 300 and 600 mg/kg but there was no teratogenicity at any dose levels. The maximum non-toxic dose level for TMS-19-Q in this study was 100 mg/kg.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D005333:Fetus / Q000187:drug effects; D007933:Leucomycins / Q000633:toxicity*; D008297:Male; D015644:Miocamycin / Q000031:analogs & derivatives*; D011247:Pregnancy; D011817:Rabbits; D012098:Reproduction / Q000187:drug effects
D007933:Leucomycins; D015644:Miocamycin; C033383:rokitamycin