Effects of clonidine on the dermal inflammatory cell response of experimental toxic and allergic contact reactions and intradermal hypersensitivity.
In previous studies, the alpha 2-adrenoceptor agonist clonidine has been shown to suppress the wheal and flare reaction in guinea pigs sensitized to ovalbumin. This phenomenon has been further studied with special reference to effects on the dermal inflammatory cell infiltrate and mast cells. Clonidine lessens the degranulation of mast cells seen in control untreated immediate hypersensitivity reactions. Less neutrophils and eosinophils arrive to the treated reactions. Basophils and mononuclear cells (chiefly lymphocytes) which characterize the late phase of the wheal and flare reaction were not influenced by clonidine. Clonidine had a possible minimal effect on allergic contact (delayed hypersensitivity) reactions. The toxic contact reaction to croton oil (nonspecific cutaneous inflammation) was not affected.
D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology*; D003436:Croton Oil / Q000009:adverse effects; D003877:Dermatitis, Contact / Q000139:chemically induced / Q000276:immunology*; D004342:Drug Hypersensitivity / Q000276:immunology*; D005260:Female; D006098:Granulocytes / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D006168:Guinea Pigs; D006632:Histamine / Q000032:analysis / Q000378:metabolism; D006968:Hypersensitivity, Delayed / Q000188:drug therapy / Q000276:immunology*; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology*; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D010047:Ovalbumin / Q000276:immunology; D010081:Oxazolone / Q000009:adverse effects; D012867:Skin / Q000032:analysis; D012882:Skin Tests / Q000379:methods
D010081:Oxazolone; D003436:Croton Oil; D006632:Histamine; D010047:Ovalbumin; D003000:Clonidine