title: HLA antigens in Behçet's disease with refractory ocular attacks.
abstract: HLA class I, II, and III antigens were studied in Japanese patients with Behçet's disease with refractory ocular attacks. In addition to the increased frequency of B51, DQw3, especially TA10-negative DQw3, was increased and DQw1 was decreased significantly in this subgroup of Behçet's disease. As for complement markers, C4A Q0 was increased. A rare variant of BF S07 was first observed in Japanese. Although the mechanism for the DQw3 association is obscure, a possible hypothesis is that an immune-response or immune-suppression gene linked to the DQ antigens modulates the disease severity and the efficacy of treatments.
mesh_terms: D001528:Behcet Syndrome / Q000276:immunology* / Q000503:physiopathology; D002825:Chorioretinitis / Q000188:drug therapy / Q000276:immunology*; D004351:Drug Resistance; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006681:HLA-D Antigens / Q000032:analysis*; D006683:HLA-DQ Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D012008:Recurrence
chemical_list: D006680:HLA Antigens; D006681:HLA-D Antigens; D006683:HLA-DQ Antigens