Effects of capsaicin pretreatment on the inflammatory response to scalding injury in the rat.
The oedema formation after scalding injury to the rat paw was studied by means of the Evans blue exudation technique. An early and a delayed oedema formation were demonstrated after severe and light scalding, respectively. It was shown that the delayed, but not the early, form was reduced by capsaicin pretreatment, suggesting an involvement of chemosensitive primary sensory neurons in this reaction.
D000818:Animals; D002056:Burns / Q000150:complications*; D002211:Capsaicin / Q000494:pharmacology*; D004487:Edema / Q000209:etiology*; D005260:Female; D009475:Neurons, Afferent / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects; D013997:Time Factors
D002211:Capsaicin