title: Stereometabolism of styrene in man. Urinary excretion of chiral styrene metabolites.
abstract: Chiral styrene metabolites obtained during initial styrene exposure of test persons were determined in urine samples using capillary gas chromatography. A typical time-dependent urinary concentration profile of one person over a 49-h period is presented and compared with the results of a previous study of occupationally exposed workers and an unexposed control group. Maximum levels of excretion of all styrene metabolites were observed at about the end of a 9-h workshift. Forty hours after exposure, the L/D-ratio of mandelic acid had subsided to the initial value, and the L/D-ratio of phenylethylene glycol to a value equal or slightly above the initial value.
mesh_terms: D001711:Biotransformation; D002849:Chromatography, Gas; D006801:Humans; D013237:Stereoisomerism; D013343:Styrenes / Q000633:toxicity / Q000652:urine*; D013997:Time Factors
chemical_list: D013343:Styrenes