[Participation of neutrophils in the cytotoxic reaction against lymphatic leukemia cells in mice].
The studies were performed on the mice, male, at the age 10 weeks, with the high-leukaemia content strains (AKR and BALB/Mo) and low-leukaemia strains (BALB/c and DBA/2) in which were observed the development of lymphatic leukaemia of virus-derivative and the stimulation of lead acetate and cadmium acetate also. Were performed: sectional and histopathological examinations, and also examined the neutrophils amount in the blood, the activity of beta-glucoronidase in these cells and the magnesium level (the roentgen microanalysis method-MAR). The investigations were conducted after 8, 16 and 35 weeks of experiment. It was found, that the strong progressive granulopenia with the simultaneous lower level of magnesium and the decrease of the beta-glucoronidase activity in these cells, accompanied the leukemia. The obtained results manifest about the increase of the inertia in the cytotoxicity of blood granulocytes in relationship to leukaemia cells moderately of the development of the neoplastic process.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D007942:Leukemia, Experimental / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009504:Neutrophils / Q000276:immunology*
Udział granulocytów obojetnochłonnych w reakcji cytotoksycznej przeciwko komórkom białaczek limfatycznych u myszy.