Expression of the c-myc gene in human gastrointestinal malignancies.
We have examined the level of the c-myc transcript in 6 esophageal, 16 gastric, 19 colorectal and 1 anal cancer tissue samples; these included four lymph nodes and six hepatic metastases obtained surgically. The esophageal cancer tissues were without an increase of the c-myc transcript, some of the gastric cancer samples showed a two to three fold increase and most of the colorectal and the one anal cancer samples showed a two to ten fold increase when compared with a normal mucosal layer. Therefore, the level of the c-myc transcript in human gastrointestinal malignancies shows organ dependency. Local, lymphatic, and hepatic metastases showed little difference in the level of c-myc mRNA from that of the primary tumor.
D000199:Actins / Q000235:genetics; D001005:Anus Neoplasms / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics; D004938:Esophageal Neoplasms / Q000235:genetics; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D009857:Oncogenes; D012333:RNA, Messenger / Q000378:metabolism; D012004:Rectal Neoplasms / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics; D014158:Transcription, Genetic
D000199:Actins; D012333:RNA, Messenger