title: The development of the amphibian trochlear nucleus. An HRP study.
abstract: The quantitative and qualitative development of the trochlear nucleus of salamanders and frogs was studied using horseradish peroxidase (HRP) as a retrograde marker. A higher number of labelled motoneurons significantly declined in later larval stages, presumably by cell death, as in birds and mammals. In agreement with this assumption, HRP-filled apoptotic cells were found in larvae. Many more labelled trochlear motoneurons were found in adult than in larval amphibians, and [3H]thymidine labelling showed postlarval cell production in the area of the trochlear nucleus. Data are discussed in the context of cell death and ongoing cell proliferation.
mesh_terms: D000557:Ambystoma; D000818:Animals; D006651:Histocytochemistry; D006735:Horseradish Peroxidase / Q000378:metabolism; D009046:Motor Neurons / Q000166:cytology; D014319:Triturus; D014321:Trochlear Nerve / Q000166:cytology*; D014982:Xenopus laevis
chemical_list: D006735:Horseradish Peroxidase