title: Lack of evidence that the XqYq pairing tips at meiosis in the mouse show hypersensitivity to DNAse I.
abstract: In situ nick translation procedures have been applied to meiotic metaphase I divisions of the normal and XY, Sxr mouse. Unlike in man, where the pairing tips of the XY bivalent show a special sensitivity to DNAse I nicking, no such sensitivity can be detected for either of these types of mouse. Hypersensitivity in the D-band equivalent region of the X chromosome does, however, exist, this site being early replicating in somatic cells and housing the X inactivation centre (Xce).
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D003850:Deoxyribonuclease I; D007621:Karyotyping; D008297:Male; D008540:Meiosis; D008677:Metaphase; D051379:Mice; D009928:Organ Specificity; D014176:Protein Biosynthesis; D012730:Sex Chromosomes / Q000648:ultrastructure*; D013093:Spermatogonia / Q000166:cytology; D013154:Spleen / Q000166:cytology
chemical_list: D003850:Deoxyribonuclease I