title: Pathogenesis of neurological signs associated with bovine enteric coccidiosis: a prospective study and review.
abstract: Various hypotheses have been proposed for the pathogenesis of the neurological signs associated with bovine enteric coccidiosis. We undertook a prospective study of cases of bovine enteric coccidiosis with and without nervous signs to test the validity of these hypotheses and explore other possible pathophysiological mechanisms. Clinical, pathological and toxicological data from 12 calves with, and 15 calves without, neurological signs were compared. Calves with neurological signs had a lower liver Cu concentration (p less than 0.01) and a higher plasma glucose concentration (p less than 0.05) than did calves without neurological signs. Hyperglycemia and Cu deficiency may increase the susceptibility to central nervous system damage, but are not likely to account for the onset of neurological signs in calves with enteric coccidiosis. The results of the study suggest that the following are not involved in the pathogenesis of "nervous coccidiosis": disturbance of serum Na, K, Ca, P, or Mg concentration, vitamin A deficiency, thiamine deficiency, anemia, lead intoxication, uremia, Haemophilus somnus meningoencephalitis, severity of coccidial infection, gross alterations in intestinal bacterial flora and hepatopathy.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases; D003044:Coccidia / Q000302:isolation & purification; D003048:Coccidiosis / Q000150:complications / Q000662:veterinary*; D003300:Copper / Q000032:analysis / Q000172:deficiency; D004573:Electrolytes / Q000097:blood; D005260:Female; D006943:Hyperglycemia / Q000150:complications / Q000662:veterinary; D007411:Intestinal Diseases, Parasitic / Q000150:complications / Q000662:veterinary*; D007422:Intestines / Q000469:parasitology / Q000473:pathology; D007501:Iron / Q000032:analysis; D008099:Liver / Q000032:analysis; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology / Q000662:veterinary*; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose; D004573:Electrolytes; D003300:Copper; D007501:Iron