The action of the tumour promoter, TPA, on mutagenesis induced by different agents (UV light, chemical and viral mutagens).
The present paper deals with effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the frequency of induced mutations to 6-mercaptopurine (6MP) and ouabain resistance in Chinese hamster and mouse cells. UV light, bovine adenovirus 3(BAV-3) and 5-bromodeoxyuridine (BrdU) were used as mutagens. TPA was shown to raise the frequency of gene mutations induced by UV light and BAV-3 but it did not enhance the mutagenic effect of BrdU. We also examined the ability of BAV-3 and BrdU to induce tumours in mice. BrdU was shown to have no carcinogenic effect. The results suggest that TPA enhances the mutagenic effect only for carcinogenic mutagens.
D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002460:Cell Line; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D015122:Mercaptopurine / Q000494:pharmacology*; D051379:Mice; D009153:Mutagens; D009154:Mutation; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014466:Ultraviolet Rays
D009153:Mutagens; D015122:Mercaptopurine; D001973:Bromodeoxyuridine; D013755:Tetradecanoylphorbol Acetate