title: Congenital retinoblastoma: a case report.
abstract: Retinoblastoma is usually diagnosed during the first three years of life, with an average age of diagnosis of 18 months. It is almost never found at birth except when there is a positive family history which prompts an early fundus examination. We report a case of unilateral nonfamilial retinoblastoma which was so advanced at birth that it had already produced a perforated globe. Despite enucleation, radiation, and chemotherapy, massive orbital recurrence developed which necessitated a modified orbital exenteration. In spite of this aggressive therapy the child died of metastatic retinoblastoma at age eight months.
mesh_terms: D003131:Combined Modality Therapy; D005134:Eye Neoplasms / Q000151:congenital* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009364:Neoplasm Recurrence, Local; D012175:Retinoblastoma / Q000151:congenital* / Q000175:diagnosis / Q000628:therapy