Glutamine protects neuronal function against cerebral hypoxia: a study using the in vitro hippocampal slice preparation.
Pretreatment of hippocampal slices with glutamine doubled the recovery rate of the synaptic function (electrically evoked population spike) from a standardized hypoxic insult in CA1 pyramidal neurons. This protective effect of glutamine was dose-dependent and biphasic; recovery of synaptic function was observed in 44% of the control slices and in 55%, 90%, 92% and 0% of slices pretreated with 0.1, 1.0, 5.0 and 10.0 mM glutamine, respectively. The synaptic function did not recover after hypoxia in slices pretreated with glutamic acid (1.0 mM).
D000818:Animals; D001927:Brain Diseases / Q000503:physiopathology*; D005973:Glutamine / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D013569:Synapses / Q000502:physiology
D005973:Glutamine