Acute synovial fluid eosinophilia associated with delayed pressure urticaria: a role for mast cells?
We report a case of exercise induced joint effusion with synovial fluid (SF) eosinophilia of 9,540/mm3 in a patient with delayed pressure urticaria. The SF eosinophilia was an acute but transient event associated with some evidence of local complement activation. Histologic assessment revealed a normal synovial membrane but with no detectable intact mast cells. These observations suggest that mast cells and eosinophils acting in concert can cause joint inflammation.
D000208:Acute Disease; D000328:Adult; D004802:Eosinophilia / Q000150:complications* / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000502:physiology*; D011312:Pressure / Q000009:adverse effects; D013582:Synovial Fluid / Q000166:cytology*; D014581:Urticaria / Q000150:complications* / Q000209:etiology