title: Vascular changes in popliteal lymph nodes due to antigen challenge in normal and lethally irradiated mice.
abstract: The microvascular system of the murine popliteal lymph node was investigated using scanning electron microscopy of microcorrosion casts. Time-dependent changes in the microvasculature following regional antigen challenge in normal and lymphocyte-depleted mice were studied. Normal lymph node microvasculature exhibited a significant increase in both the vascular bed and post-capillary venules containing high-endothelium in response to antigen challenge. Lymph nodes of lymphocyte-depleted mice showed no microvascular size increase following antigen challenge and a reduction in the amount of high-endothelium was observed.
mesh_terms: D000818:Animals; D002196:Capillaries / Q000528:radiation effects / Q000648:ultrastructure; D004727:Endothelium / Q000528:radiation effects / Q000648:ultrastructure; D005260:Female; D008198:Lymph Nodes / Q000098:blood supply* / Q000528:radiation effects / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008833:Microcirculation / Q000528:radiation effects / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning / Q000379:methods; D013997:Time Factors; D014699:Venules / Q000528:radiation effects / Q000648:ultrastructure