Penetration of cefonicid in skin suction blister fluid in healthy volunteers.
A new cephalosporin, cefonicid (1 g) was given intramuscularly to six healthy volunteers 12 h after induction of skin suction blister. Serum and blister fluid were collected during a 24 h period. Antibiotic assay was made by a microbiological method. The data were analysed by a one-compartment kinetic model. Despite the high protein binding, cefonicid penetrated in microbiologically effective concentration into blister fluid. Blister fluid concentrations were higher than the serum concentrations at 24 h.
D000328:Adult; D001768:Blister / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism*; D002435:Cefamandole / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D015790:Cefonicid; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male
D002435:Cefamandole; D015790:Cefonicid