title: [Degree of stability of metabolic chain with 1 feedback loop].
abstract: Relationship was studied between the stability degree of the metabolic chain with one loop of the negative feedback and force of coupling and values of characteristic times of the chain reactions. For the chain with arbitrary values of characteristic times of individual stages the maximal possible degree of the chain stability and corresponding value of the feedback coefficient are estimated. It has been shown that the increase of the characteristic time of one (no more) reaction and decrease of the sum of characteristic times of other reactions which it is of advantage to make equal makes it possible to combine high degree of dynamic stability and consequently sufficient rate of transitory processes in the chain with a high quality of stabilization of the final product, i.e. with a strong negative feedback.
mesh_terms: D005246:Feedback; D008433:Mathematics; D008660:Metabolism; D008954:Models, Biological
vernacular_title: Stepen' ustoĭchivosti metabolicheskoĭ tsepi s odnoĭ petleĭ obratnoĭ sviazi.