DNA binding studies on 1OH-pyrrolizino[1,2-b]quinolines.
1OH-Pyrrolizino [1,2-b]quinolines exhibited intercalation when tested by the following methods: effect of DNA on spectral properties, spectrophotometric titration, fluorescence enhancement of homidium bromide (ethidium bromide), thermal denaturation of DNA, effect on covalently closed circular double stranded PM-2 (Col E 1 plasmid) DNA. Some of the compounds showed antiproliferative activity in HeLa cells.
D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D007364:Intercalating Agents / Q000494:pharmacology*; D009691:Nucleic Acid Denaturation; D011804:Quinolines / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence
D007364:Intercalating Agents; D011804:Quinolines; D004247:DNA