Antiarrhythmic effects of a novel diamine derivative, AN-132, on several animal models of cardiac arrhythmias.
The antiarrhythmic activities of AN-132, 3-(diisopropylaminoethylamino)-2',6'-dimethylpropionanilide X 2H3PO4, compared with three reference drugs, were examined in several arrhythmic models of rats, guinea-pigs and dogs. When compared on a weight basis, AN-132 given in oral or i.v. route proved to be more potent and longer-acting than disopyramide, propaphenone and mexiletine against supraventricular and ventricular arrhythmias induced by chloroform, aconitine, ouabain and halothane-adrenaline.
D000157:Aconitine; D000813:Anilides / Q000627:therapeutic use*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D002725:Chloroform; D004206:Disopyramide / Q000627:therapeutic use; D004285:Dogs; D004837:Epinephrine; D005029:Ethylenediamines / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D006221:Halothane; D008297:Male; D008801:Mexiletine / Q000627:therapeutic use; D010042:Ouabain; D011405:Propafenone / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
C053205:3-(diisopropylaminoethylamino)-2',6'-dimethylpropionanilide, diphosphoric acid; D000813:Anilides; D000889:Anti-Arrhythmia Agents; D005029:Ethylenediamines; D008801:Mexiletine; D010042:Ouabain; D011405:Propafenone; D002725:Chloroform; D004206:Disopyramide; D006221:Halothane; D000157:Aconitine; D004837:Epinephrine