title: Effects of co-administration of monomethylaminoantipyrine and cobaltous chloride on hepatic glutathione level and glutathione-related enzyme activities in rats.
abstract: Concurrent administration of monomethylaminoantipyrine (MAA) and CoCl2 caused a significant decrease of hepatic reduced glutathione and oxidized glutathione levels. Furthermore, the increase of glutathione S-transferase activity by combined treatment resulted in the decrease of Se-dependent glutathione peroxidase activity.
mesh_terms: D000632:Aminopyrine / Q000031:analogs & derivatives*; D000818:Animals; D003035:Cobalt / Q000494:pharmacology*; D004177:Dipyrone / Q000031:analogs & derivatives* / Q000494:pharmacology; D004326:Drinking / Q000187:drug effects; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D047069:Pyrazolones; D051381:Rats; D011919:Rats, Inbred Strains; D014166:Transferases / Q000378:metabolism
chemical_list: D047069:Pyrazolones; D000632:Aminopyrine; D003035:Cobalt; D004177:Dipyrone; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D014166:Transferases; C018021:cobaltous chloride; D005978:Glutathione; C008667:noramidopyrine