title: Interdependent regional lung emptying during forced expiration: a transistor model.
abstract: We recognized similarities between isovolume pressure-flow curves of the lung and emitter-collector voltage-current characteristics of bipolar transistors, and used this analogy to model expiratory flow limitation in a two-generation branching network with parallel nonhomogeneity. In this model, each of two bronchi empty parenchymal compliances through a common trachea, and each branch includes resistances upstream and downstream of a flow-limiting site. Properties of each airway are specified independently, allowing simulation of differences between the tracheal and bronchial generations and between the parallel bronchial paths. Simulations of four types of parallel asymmetry were performed: unilateral peripheral bronchoconstriction; unilateral central bronchoconstriction; asymmetric redistribution of parenchymal compliance; and unilateral alteration of the bronchial area-transmural pressure characteristic. Our results indicate that multiple axial choke points can exist simultaneously in a symmetric lung when large airway opening-pleural pressure gradients exist; despite severe nonhomogeneity of regional lung emptying, flow interdependence among parallel branches tends to maintain a near normal configuration of the overall maximal expiratory flow-volume (MEFV) curve throughout a large fraction of the vital capacity; and sudden changes of slope of the MEFV curve ("knees" or "bumps") may reflect choking in one branch in a nonuniform lung, but need not be obvious even when severe heterogeneity of lung emptying exists.
mesh_terms: D000403:Airway Resistance; D000818:Animals; D001980:Bronchi / Q000473:pathology / Q000503:physiopathology; D003198:Computer Simulation; D003251:Constriction, Pathologic; D004582:Electronics, Medical; D005540:Forced Expiratory Flow Rates; D006801:Humans; D008168:Lung / Q000502:physiology*; D008449:Maximal Expiratory Flow-Volume Curves; D008954:Models, Biological; D012119:Respiration