title: [Cholagogic effect of trimethylglycine in normal animals of different ages and in experimental atherosclerosis].
abstract: Trimethylglycine at a dose of 1.5 g/kg was found to produce marked bile secretory effect in young and old rats. In rabbits with experimental atherosclerosis, trimethylglycine increased the content of biliary acids in the bile and normalized the indexes of lipid metabolism in the blood serum. Apparently, the effect on cholesterol transformation into biliary acids and its excretion with the bile is one of the mechanisms of anti-atherosclerotic action of trimethylglycine.
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000378:metabolism; D001622:Betaine / Q000494:pharmacology* / Q000627:therapeutic use; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D002756:Cholagogues and Choleretics / Q000494:pharmacology* / Q000627:therapeutic use; D002793:Cholic Acids / Q000494:pharmacology; D003685:Dehydrocholic Acid / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013997:Time Factors
chemical_list: D002756:Cholagogues and Choleretics; D002793:Cholic Acids; C002001:allocholic acid; D001622:Betaine; D003685:Dehydrocholic Acid
vernacular_title: Zhelchegonnyĭ éffekt trimetilglitsina u zhivotnykh raznogo vozrasta v norme i pri éksperimental'nom ateroskleroze.