Lack of cytoprotection by acetaminophen against ethanol-, HCl.ethanol- and HCl.aspirin-induced gastric mucosal lesions in rats.
Effects of acetaminophen against gastric mucosal lesions induced by three different necrotizing agents were studied. Acetaminophen (30, 100 mg/kg), given p.o. 0.5 hr before absolute ethanol, HCl . ethanol, or HCl . aspirin administration, afforded no cytoprotection against gastric mucosal lesions induced by the above agents in 24 hr fasted rats. However, 16,16-dimethyl prostaglandin E2 (3 micrograms/kg), given p.o. 0.5 hr before these necrotizing agents, completely prevented development of these lesions.
D015064:16,16-Dimethylprostaglandin E2 / Q000494:pharmacology; D000082:Acetaminophen / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000037:antagonists & inhibitors; D000431:Ethanol / Q000037:antagonists & inhibitors; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D006851:Hydrochloric Acid / Q000037:antagonists & inhibitors; D008297:Male; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains
D000082:Acetaminophen; D000431:Ethanol; D015064:16,16-Dimethylprostaglandin E2; D006851:Hydrochloric Acid; D001241:Aspirin