title: Mammalian motoneuron cell death: development of the lateral motor column of a wallaby (Macropus eugenii).
abstract: We have investigated the development of the lumbar lateral motor column of the tammar as a model of mammalian motoneuron cell death that is accessible to experimental manipulation. The tammar is an Australian marsupial, belonging to the subfamily of wallabies and kangaroos. After a gestational period of 26-28 days, the pup crawls to its mother's pouch using its forelimbs. The major morphometric events that shape the formation of the hindlimb occurred between 21 days gestation and birth. At birth the premuscle masses had divided and motor nerves had begun to penetrate the muscles of the thigh and shank. The period of motoneuron cell death was biphasic and occurred entirely postnatally. During phase I, between birth and 40 days, 59% of motoneurons were lost. Cell numbers then stabilised before falling a further 24%, to give an overall loss of 70%. Most of phase II cell loss occurred between 90 and 150 days. The possibility that a second period of motoneuron cell death may be a common feature of mammals is discussed.
mesh_terms: D000818:Animals; D002452:Cell Count; D002470:Cell Survival; D005333:Fetus; D006614:Hindlimb / Q000294:innervation; D006735:Horseradish Peroxidase; D008394:Marsupialia / Q000502:physiology*; D009046:Motor Neurons / Q000502:physiology*; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology / Q000254:growth & development*
chemical_list: D006735:Horseradish Peroxidase