title: [Hypolipidemic action of the racemic methyl ester of 16,16-dimethyl-D-homo-8-isoestrone].
abstract: Racemic 16,16-dimethyl-D-homo-8-isoestrone methyl ester (substance 1) was shown to decrease the content of cholesterol in blood serum and liver tissue of animals with induced hyperlipidemia (rats, guinea pigs, rabbits) as well as to decrease the rate of atherosclerotic impairments in rabbit aorta. As distinct from usual estrogen, the substance I did not cause hypertriglyceridemia but normalized triglycerides in blood and liver tissue. Substance I exhibited low toxic effects.
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D004958:Estradiol / Q000494:pharmacology; D004970:Estrone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000378:metabolism; D006168:Guinea Pigs; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008297:Male; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013237:Stereoisomerism; D014280:Triglycerides / Q000097:blood
chemical_list: D005230:Fatty Acids, Nonesterified; D006065:Gonadotropins, Pituitary; D000960:Hypolipidemic Agents; D008055:Lipids; D014280:Triglycerides; C052894:16,16-dimethyl-D-homo-8-isoestrone methyl ester; D004970:Estrone; D004958:Estradiol; D002784:Cholesterol
vernacular_title: Gipolipidemicheskoe deĭstvie ratsemicheskogo metilovogo éfira 16,16-dimetil-D-gomo-8-izoéstrona.