Efficacy of enprofylline, a new bronchodilating xanthine, in acute asthma.
Five different doses of enprofylline, a 3-propylxanthine, were compared with a standard dose of theophylline in 135 episodes of acute asthma in a double-blind study. The drugs were administered intravenously during ten minutes. Enprofylline induced dose-related bronchodilation and the 2.5 mg/kg dose produced significantly better effects than theophylline.
D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D013224:Status Asthmaticus / Q000188:drug therapy*; D013806:Theophylline / Q000097:blood / Q000627:therapeutic use; D014970:Xanthines / Q000097:blood / Q000627:therapeutic use*
D001993:Bronchodilator Agents; D014970:Xanthines; D013806:Theophylline; C034347:enprofylline