Multicompartment models of cancer chemotherapy incorporating resistant cell populations.
The pharmacokinetics of antineoplastic drugs based on compartmental models are combined with deterministic exponential growth models of tumors containing drug-resistant and sensitive cells. Model predictions for single-drug therapy are compared with in vivo data obtained by other investigators for L1210 t-cell leukemia in mice treated with BCNU and Ara-C and for in vitro treatment of L1210 with Ara-C. The model and data compare favorably in terms of rate of tumor growth and duration of drug action for both constant infusion and bolus delivery of the drugs.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001682:Biological Availability; D002330:Carmustine / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use; D004351:Drug Resistance; D007700:Kinetics; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008954:Models, Biological
D000970:Antineoplastic Agents; D003561:Cytarabine; D002330:Carmustine