Fragile sites are unrelated to reciprocal translocation breakpoints.
In 492 cases of reciprocal translocations in balanced carriers, the 984 breakpoints were studied for a possible relationship to the 45 fragile sites. Random coincidence was predicted at 14% and the observed coincidence was 14.3%, indicating that the two events are unrelated. However, chromosomes 1, 11 and 14 were exceptions and did show a statistically significant relationship.
D000022:Abortion, Spontaneous / Q000235:genetics; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D014178:Translocation, Genetic