Influence of saccharin on Polycose, sucrose, and glucose intake and preference in rats.
The effect of adding 0.125% saccharin to 3% or 32% solutions of Polycose, sucrose and glucose on the fluid intake and preference of adult female rats was examined. In Experiment 1, the rats consumed more of a 3% Polycose + 0.125% saccharin solution (P + s) than of either a 3% Polycose or 0.125% saccharin solution; similar results were obtained with sucrose + saccharin (S + s) and glucose + saccharin (G + s) solutions. The polydipsic effects of the P + s, S + s, and G + s solutions were comparable (225 to 278 ml/day). Adding saccharin to 32% Polycose, sucrose, or glucose solutions did not increase solution intake. In two-solution preference tests, though, the rats preferred the 32% Polycose + saccharin and 32% glucose + saccharin solutions to 32% Polycose and 32% glucose solutions, respectively. Saccharin did not reliably affect the preference for the 32% sucrose solution. In Experiment 2, the preference for 3% carbohydrate solutions was assessed using two-solution tests. The rats preferred 3% sucrcose to 3% Polycose or 3% glucose; they also preferred 3% Polycose to 3% glucose. When saccharin was added to the solutions, the rats displayed equal preferences for the S + s and P + s solutions, and for the P + s and G + s solutions but they strongly preferred the S + s to the G + s solution. Recent findings suggest that polysaccharides such as Polycose taste qualitatively different from sucrose and saccharin to rats, i.e., have a "nonsweet" taste.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D005518:Food Preferences; D005936:Glucans; D005947:Glucose; D051381:Rats; D012439:Saccharin / Q000494:pharmacology*; D013395:Sucrose
D005936:Glucans; D013395:Sucrose; D012439:Saccharin; D005947:Glucose