Early adventures in drug metabolism: 2. The absorption of drugs.
This paper deals with our experiences in drug metabolism in the Parke-Davis Research Laboratories at a time when good analytical procedures were just starting to make their appearance and pharmacokinetics was an undiscovered territory. Some of our groping efforts to understand the factors influencing absorption are described. These included formulation differences in generic products and their effect upon absorption. Compounds such as p-aminosalicylic acid, chloramphenicol, phenytoin and acedapsone are used as examples. Our intent is to show how our knowledge of drug metabolism developed during this period, and to describe some areas that still need additional investigation.
D000042:Absorption; D010131:Aminosalicylic Acid / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001830:Body Surface Area; D002648:Child; D002701:Chloramphenicol / Q000378:metabolism; D004304:Dosage Forms; D006801:Humans; D007273:Injections, Intramuscular; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D010672:Phenytoin / Q000378:metabolism
D004304:Dosage Forms; D004364:Pharmaceutical Preparations; D010131:Aminosalicylic Acid; D010672:Phenytoin; D002701:Chloramphenicol