title: [Chemotherapy of dysgerminoma].
abstract: Two patients with metastases after primary surgery to remove a dysgerminoma were successfully treated by chemotherapy. One received monotherapy with chlorambucil, the other vinblastine, bleomycin and cisplatin followed by irradiation. Both survived 5 years without evidence of disease. Dysgerminomas are highly sensitive not only to irradiation but also to chemotherapy. It is suggested that in younger women, in order to preserve fertility, chemotherapy should be used after primary conservative surgery, and irradiation only as a third-line remedy.
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002699:Chlorambucil / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D004407:Dysgerminoma / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D002699:Chlorambucil; D003609:Dactinomycin; D003520:Cyclophosphamide; D005472:Fluorouracil
vernacular_title: Chemotherapie des Dysgerminoms.