Adenosine receptor agonists inhibit inositol phosphate accumulation in rat striatal slices.
The accumulation of inositol-1-phosphate in rat striatal slices was inhibited by the adenosine analogues 5'-N-ethylcarboxamide-adenosine and N6-phenylisopropyladenosine. Maximal inhibition (approximately 20%) was achieved by micromolar concentrations of either compound. Both basal and stimulated values could be inhibited, and the inhibition was reversible by the adenosine receptor antagonist 8-phenyltheophylline (10 microM). The results suggest that adenosine may exert a tonic inhibitory influence on inositol phospholipid-derived second messenger production in the striatum in vivo.
D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D019830:Adenosine-5'-(N-ethylcarboxamide); D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007295:Inositol Phosphates / Q000378:metabolism*; D008297:Male; D010660:Phenylisopropyladenosine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011983:Receptors, Purinergic / Q000502:physiology*; D013403:Sugar Phosphates / Q000378:metabolism*
D007295:Inositol Phosphates; D011983:Receptors, Purinergic; D013403:Sugar Phosphates; D010660:Phenylisopropyladenosine; D019830:Adenosine-5'-(N-ethylcarboxamide); D006632:Histamine; D000241:Adenosine; D004298:Dopamine