Age-related differences in lymphocyte adherence to myelinated tissue in multiple sclerosis.
Human peripheral blood lymphocytes were obtained from patients with MS and from healthy controls. Comparisons were made between the adherence of lymphocytes from donors of varying ages to myelin from donors of different age groups at the time of death. The adherence of control lymphocytes was maximum with lymphocytes from donors in their 30s. No obvious maximum for lymphocyte age was found for adherence of MS lymphocytes. However, MS adherence levels were significantly higher than control levels at most ages tested. Maximum adherence levels were observed for both MS and control cells with myelin from donors who were 20 to 45 years of age at the time of death. No significant difference between MS and control adherence to myelin from elderly donors was observed. Possible age-related changes in myelin and the relationship of maximum adherence to the peak age of onset of MS discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000276:immunology / Q000502:physiology*; D001921:Brain / Q000276:immunology / Q000502:physiology*; D002448:Cell Adhesion; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000502:physiology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology / Q000503:physiopathology*; D009186:Myelin Sheath / Q000276:immunology / Q000502:physiology*