Mexiletine use in pregnancy and lactation.
Treatment of arrhythmias during pregnancy is complicated by insufficient information on the effects of the drug on the fetus or possible alterations of the drug's pharmacodynamics in the mother. The use of mexiletine, a newly introduced antiarrhythmic agent, during the entire course of pregnancy and subsequent lactation is presented.
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D008801:Mexiletine / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D008895:Milk, Human / Q000378:metabolism*; D011247:Pregnancy / Q000187:drug effects*; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy
D000889:Anti-Arrhythmia Agents; D008801:Mexiletine