Requirement of extracellular Ca2+ after tetanus for induction of long-term potentiation in guinea pig hippocampal slices.
Long-term potentiation (LTP) is the persistent facilitation of synaptic responses induced by a brief tetanic stimulation (tetanus). Replacement of a standard solution containing 2.0 mM Ca2+ with one containing 1.0 mM Ca2+ for 5 min, either immediately after or during tetanus, significantly inhibited the induction of LTP. Furthermore, similar results were obtained when Verapamil or Loperamide, presumable Ca2+ antagonists, was applied immediately after tetanus. From these results, it was concluded that the induction of LTP requires extracellular Ca2+ after as well as during tetanus.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004558:Electric Stimulation; D004594:Electrophysiology; D005071:Evoked Potentials; D006168:Guinea Pigs; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology*; D008139:Loperamide / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D008139:Loperamide; D014700:Verapamil; D002118:Calcium