[Determination of the amount of somatic cell glucocorticoid receptors as one of the prospective approaches to the individual prognosis of glucocorticosteroid therapy].
The authors discuss the importance of the content of receptors to glucocorticosteroid hormones in somatic cells to predict the effectiveness of glucocorticosteroid therapy. Prognostically important is the detection of a relatively low amount of receptors in cells when administration of corticosteroids at high doses might be most probably ineffective. Any human somatic cells are representative (with respect to the receptor content) for other cell types therefore investigation of the number of glucocorticoid receptors in lymphocytes (the quickest result) or in skin biopsy specimens (less traumatic for a patient) seems most effective.
D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation / Q000379:methods; D004351:Drug Resistance; D005921:Glomerulonephritis / Q000188:drug therapy / Q000378:metabolism; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D011379:Prognosis; D011965:Receptors, Glucocorticoid / Q000032:analysis* / Q000378:metabolism
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid
Opredelenie kolichestva gliukokortikoidnykh retseptorov somaticheskikh kletok--odin iz perspektivnykh podkhodov k individual'nomu prognozirovaniiu gliukokortikosteroidnoĭ terapii.