[Experimental verification of the use of lithium oxybutyrate for the drug prevention of alcoholism relapses].
It was found that lithium oxybutyrate suppresses voluntary consumption of 5% ethanol solution in rats with preliminarily formed alcohol motivation, slows down the formation of alcohol addiction under conditions of forced consumption of 5% ethanol solution and exerts a positive effect on general state of the animals subjected to a long-term action of ethanol by improving the conditioned reflex activity of the central nervous system and stimulating defensive-adaptational mechanisms of the organism.
D000428:Alcohol Drinking / Q000187:drug effects; D000437:Alcoholism / Q000517:prevention & control*; D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D008297:Male; D009942:Organometallic Compounds / Q000627:therapeutic use*; D051381:Rats; D012008:Recurrence; D013997:Time Factors
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; C022826:lithium hydroxybutyrate
Eksperimental'noe obosnovanie primeneniia litiia oksibutirata dlia farmakoprofilaktiki retsidivov alkogolizma.