Serum prolactin levels after buspirone in man.
The acute effects of buspirone, an anxiolytic with mixed dopamine (DA) agonist-antagonist properties (achieved by blocking pre- and postsynaptic receptors) on serum prolactin (PRL) were studied in cross-over and double-blind trials in ten healthy young males. Sulpiride (200 mg) was used as a control drug; it raised PRL by almost 800%. Buspirone (25, 50 and 100 mg) raised serum PRL dose-dependently; the greatest increases (30, 70, and 320% from baseline, respectively) were seen 1 h after each dose. The results suggest that buspirone blocks postsynaptic DA receptors only at doses higher than those needed for anxiolysis.
D000328:Adult; D002065:Buspirone; D004311:Double-Blind Method; D004341:Drug Evaluation; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood*; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D011954:Receptors, Dopamine / Q000187:drug effects
D011743:Pyrimidines; D011954:Receptors, Dopamine; D011388:Prolactin; D002065:Buspirone