title: Combined chronic toxicity and carcinogenicity studies of morpholine oleic acid salt in B6C3F1 mice.
abstract: Morpholine oleic acid salt (MOAS) was administered to groups of 50 male and 50 female B6C3F1 mice in the drinking-water at levels of 0, 0.25 and 1.0%. Both sexes given 1.0% MOAS and females given 0.25% showed growth retardation. Significant increases in blood-urea nitrogen concentrations were only observed in the 1.0% male group. The incidence of squamous-cell hyperplasia of the forestomach epithelium was significantly higher in the males given 1.0% than in the controls. The male mice given 0.25% MOAS had a significantly reduced incidence of hepatocellular carcinoma in comparison with the control group and this trend was indicated also in the 1.0% group. This experiment did not demonstrate any carcinogenic effect of MOAS in mice at levels up to 1.0% in the drinking-water.
mesh_terms: D000818:Animals; D002273:Carcinogens; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D006965:Hyperplasia / Q000139:chemically induced; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D051379:Mice; D009025:Morpholines / Q000633:toxicity*; D009829:Oleic Acids / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects
chemical_list: D002273:Carcinogens; D009025:Morpholines; D009829:Oleic Acids; C037574:morpholine