Antitumor effect of i.p. dopamine in mice bearing Ehrlich ascites carcinoma.
The cancer chemotherapeutic efficacy of dopamine (DA) was evaluated in female strain A mice bearing transplantable Ehrlich ascites carcinoma. The results demonstrated significant inhibition of tumor growth with appreciable increase in the host survival time following DA treatment. Diminished activity of the growth-related respiratory enzyme succinate dehydrogenase along with stimulated activity of the lysosomal enzyme, beta-glucuronidase in DA-treated tumor cells indicated inhibition of tumor growth as well as active lysis of the tumor cells. The direct effect of this compound on tumor proliferation was demonstrated by marked inhibition of DNA synthesis. RNA synthesis was only marginally inhibited.
D000818:Animals; D000970:Antineoplastic Agents; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D004789:Enzyme Activation; D005260:Female; D005966:Glucuronidase / Q000378:metabolism; D007274:Injections, Intraperitoneal; D051379:Mice; D008805:Mice, Inbred A; D012334:RNA, Neoplasm / Q000096:biosynthesis; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D013385:Succinate Dehydrogenase; D005966:Glucuronidase; D004298:Dopamine