title: Observations on the migratory behaviour of Schwann cells from adult peripheral nerve explant cultures.
abstract: The migration of Schwann cells from adult sciatic nerve explant cultures has been examined by time-lapse photomicrography. Analysis of Schwann cell migratory behaviour indicates that the initial outwandering by individual Schwann cells was random. Although chance cell-cell contacts resulted in temporary immobilization of pairs of cells, stable multicellular structures did not form during this initial phase. As local cell densities increased, Schwann cells assembled networks within which Schwann cell movement continued to be observed. A second form of Schwann cell outgrowth was observed from degenerating fibres in which arrays of highly oriented Schwann cells migrated away from their basal lamina tubes onto the culture dish. These observations of Schwann cell random migration, network self-assembly and coordinated extratubal migration are considered to highlight aspects of Schwann cell behaviour, independent of axonal influences, which may have relevance to their role in peripheral nerve repair following nerve section.
mesh_terms: D000818:Animals; D001369:Axons / Q000648:ultrastructure; D002415:Cats; D002465:Cell Movement; D046508:Culture Techniques; D009416:Nerve Regeneration; D012583:Schwann Cells / Q000648:ultrastructure*; D012584:Sciatic Nerve / Q000033:anatomy & histology*