title: Biologically motivated cancer risk models.
abstract: A two-stage dose response model is proposed for use in cancer risk assessment. The model assumes that transformation probabilities and cellular dynamics are exposure- and time-dependent.
mesh_terms: D000818:Animals; D001681:Biological Assay; D002273:Carcinogens / Q000009:adverse effects / Q000145:classification; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced* / Q000235:genetics; D003043:Cocarcinogenesis; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D008954:Models, Biological; D009154:Mutation; D009929:Organ Size; D011230:Precancerous Conditions / Q000139:chemically induced / Q000235:genetics; D051381:Rats; D012306:Risk
chemical_list: D002273:Carcinogens