Inhibition of induced acute lung edema by a novel protein kinase C inhibitor.
The effect of the protein kinase C enzyme inhibitor H-7 on the noncardiogenic lung edema induced by phorbol myristate acetate (PMA) in mice was examined. Lung edema was assessed by measurement of 125I-labeled albumin leak into the lung. The results showed that pretreatment of mice with H-7 nearly prevents the albumin leak induced by PMA, whereas post-PMA treatment with H-7 had less of an effect on the albumin leak, although it was still significant.
D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D000418:Albumins / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal / Q000378:metabolism; D004789:Enzyme Activation; D007546:Isoquinolines / Q000494:pharmacology / Q000627:therapeutic use*; D008168:Lung / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D011654:Pulmonary Edema / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D012128:Respiratory Distress Syndrome / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
D000418:Albumins; D007546:Isoquinolines; D010879:Piperazines; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate