title: Vitamin E is immunostimulatory in calves.
abstract: Thirty-two Holstein heifer calves, eight per group, were fed 0, 125, 250 or 500 IU/d of supplemental vitamin E/calf, from birth to 24 wk of age, in order to determine the effect on their immune responses. Overall mean lymphocyte blastogenic responses to various T-cell and B-cell mitogens were higher in supplemented calves than in control calves. Mean concentrations of cortisol in serum were lower in all supplemented calves than in control calves. Antibovine herpes-virus type 1 antibody titer (IgG) at 8 and 9 wk, in response to a commercial modified-live intranasal vaccine at 7 wk, was similar in all treatment groups. At 24 wk, in response to a booster at 21 wk, titer was higher in calves given 125 IU of vitamin E/d than in control calves. Based on the concentrations used, it is concluded that supplementation of conventional rations with 125 IU of vitamin E/d may maximize immune responses in calves and may be cost effective.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D000917:Antibody Formation / Q000187:drug effects*; D002417:Cattle / Q000276:immunology*; D005260:Female; D006564:Herpesviridae / Q000276:immunology*; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000914:Antibodies, Viral; D014810:Vitamin E