Single-dose bromocriptine reverses cocaine craving.
Thirteen hospitalized cocaine addicts complaining of cocaine craving were given a single dose of bromocriptine, a dopamine agonist, in a randomized, double-blind, placebo-controlled study design. Compared to placebo, bromocriptine caused a significant reduction in craving ratings. These data suggest that bromocriptine may be effective as a new, nonaddictive pharmacological treatment for cocaine addicts and support the notion that functional dopamine depletion occurs with chronic cocaine use. Open trials indicate that low-dose bromocriptine may be useful in cocaine detoxification.
D000328:Adult; D001971:Bromocriptine / Q000008:administration & dosage*; D003042:Cocaine; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D011581:Psychological Tests; D019966:Substance-Related Disorders / Q000523:psychology / Q000534:rehabilitation*
D001971:Bromocriptine; D003042:Cocaine