Promotion by L-ascorbic acid of urinary bladder carcinogenesis in rats under conditions of increased urinary K ion concentration and pH.
Dietary administration of 5% L-ascorbic acid plus 3% K2CO3 to male F344 rats clearly enhanced the development of preneoplastic and neoplastic lesions of the urinary bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Promotion of carcinogenesis by L-ascorbic acid and K2CO3 was associated with changes in urinary parameters: elevation of pH, increased K+ concentration, and increase in total ascorbic acid.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002085:Butylhydroxybutylnitrosamine; D006863:Hydrogen-Ion Concentration; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011188:Potassium / Q000652:urine*; D051381:Rats; D011916:Rats, Inbred F344; D012964:Sodium / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D002085:Butylhydroxybutylnitrosamine; D012964:Sodium; D001205:Ascorbic Acid; D011188:Potassium