A study of erythrocyte insulin receptors in normal Indian and African volunteers.
125I-insulin binding to erythrocytes were compared between 19 Indian and African healthy volunteers matched for age, sex and body mass index. There were no significant differences in 125I-insulin binding between Indians and Africans (maximum specific binding 9.13 +/- 0.52% and 8.74 +/- 0.51% respectively, p = 0.29). However, when 125I-insulin binding was compared between 16 males and females matched for age and body mass index, the males had significantly higher specific binding than the females (maximum specific binding 9.8 +/- 0.6% and 7.9 +/- 0.4% respectively, p less than 0.01). This difference in binding was due to a lower receptor number in females as evidence by Scatchard analysis; ID50 values revealed similar receptor affinities. In conclusion, while there is no difference in receptor binding between Indians and Africans, males have significantly higher specific binding than females.
D000328:Adult; D000349:Africa; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000208:ethnology; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007194:India / Q000208:ethnology; D008297:Male; D011972:Receptor, Insulin / Q000378:metabolism*
D011972:Receptor, Insulin