[Estimate of the penetrance of genotypes in a monolocus model taking into account environmental factors].
Based on ITO matrices, a method for parameter estimation of the monolocus diallele model (MDM) of qualitative trait is described, taking account of non-genetic (environmental) factors. The model parameters, probabilities of relatives' affection, constructing the likelihood function and testing hypotheses of the effect of environmental factors on the penetrations of MDM genotypes are outlined. Examples are given, concerning estimation of epilepsy MDM parameters, taking account of two factors-harmfulness of antenatal ontogenesis period and harmfulness which provokes paroxysms.
D000483:Alleles; D004777:Environment; D005826:Genetics, Medical; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D011336:Probability
Otsenivanie penetrantnosteĭ genotipov monolokusnoĭ modeli s uchetom faktorov sredy.