Metabolism of halothane in children having repeated halothane anaesthetics.
Metabolism of halothane was studied in nine children receiving daily halothane anaesthetics (from 10 up to a maximum of 31) over periods of two to seven weeks. Serum bromide concentrations never exceeded 3.5 mmol/l, a concentration below the toxic threshold. Repeated halothane anaesthetics at short intervals did not induce the reductive metabolism of halothane as assessed by 2-chloro-1,1,1-trifluoroethane (CTF) in the expired breath. One patient developed viral hepatitis A during the course of anaesthetic administration; this patient was the only one whose serum bromide concentrations fell substantially and whose exhaled CTF concentration increased as more anaesthetics were administered.
D000328:Adult; D000769:Anesthesia, Inhalation; D001965:Bromides / Q000097:blood; D002648:Child; D005260:Female; D006221:Halothane / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D013997:Time Factors
D001965:Bromides; C016800:1,1,1-trifluoro-2-chloroethane; D006221:Halothane