[Progressive multifocal leukoencephalopathy. Late complication in chronic lymphatic leukemia].
In a 44 year old patient with chronic lymphatic leukemia and secondary antibody deficiency syndrome, a disorder of articulation and a left hemiparesis developed during a thrombocytopenic phase. Computer tomography of the cranium, CSF diagnostics and the electroencephalogram did not provide any indication for the cause of the rapidly progressive cerebral symptoms. In the NMR tomogram, a diffusedly increasing intensity in the T2-weighted tomograms were shown around the central region in the right brain. The patient died of a Pseudomonas septicemia. At autopsy, a typical finding of progressive multifocal leukoencephalopathy was found in the areas altered in the NMR tomography. Papova-like virions could be demonstrated in glial cells by electron microscopy.
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D004569:Electroencephalography; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007945:Leukemia, Lymphoid / Q000150:complications*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009457:Neuroglia / Q000648:ultrastructure; D027383:Papillomaviridae / Q000648:ultrastructure; D027382:Polyomaviridae; D014057:Tomography, X-Ray Computed; D014771:Virion / Q000648:ultrastructure
Progressive multifokale Leukoenzephalopathie. Spätkomplikation bei chronischer lymphatischer Leukämie.