[Clinical long-term studies on cefuzoname in patients with complicated urinary tract infections].
Cefuzoname (CZON), a new semisynthetic cephalospolin antibiotic, was administered intravenously at a dose of 1.0 g twice a day for 14 days to 20 patients with complicated urinary tract infections and the therapeutic efficacy of the drug and safety were evaluated. The results obtained were summarized as follows: 1. After 5 days, clinical results were excellent in 7, moderate in 3 and poor in 9 cases. The overall effectiveness rate was 52.6%. Bacteriologically, 24 out of 32 isolated strains were susceptible to this drug, but 8 strains were found to be resistant. 2. After treatment, clinical results were excellent in 6, moderate in 3 and poor in 10 cases. The overall effectiveness was 47.4%. In bacteriological results of 32 isolated strains, 26 strains were eradicated and 6 strains persisted. 3. Among 20 cases treated none showed subjective or objective symptoms of side effects. Noted as clinical laboratory test abnormalities were eosinophilia in 1 case after 5 days, increase of S-GOT, gamma-GTP, and K in 1 case, and increase of S-creatinine in 1 case at the termination of treatment. All of these abnormalities were mild and normal values were restored soon after at the termination of the treatment.
D000328:Adult; D000368:Aged; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification; D015296:Ceftizoxime / Q000031:analogs & derivatives*; D002511:Cephalosporins / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
D002511:Cephalosporins; C049934:cefuzonam; D015296:Ceftizoxime