title: Further evidence that stress hyperthermia is a fever.
abstract: Exposure of rats to an open-field results in a rapid rise in body temperature. Fifty-four percent of this rise in body temperature was blocked by intracerebroventricular administration of the antipyretic drug sodium salicylate. Intraperitoneal administration of indomethacin, a potent blocker of prostaglandin production, also attenuated the stress-induced hyperthermia to the same degree. Based on the data presented in this and an earlier study, we conclude that a major component of the rise in body temperature induced by psychological stress in rats is mediated by prostaglandins released by the central nervous system, and may therefore be a fever.
mesh_terms: D000818:Animals; D001831:Body Temperature; D005334:Fever / Q000209:etiology*; D007213:Indomethacin; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D011453:Prostaglandins / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012980:Sodium Salicylate; D013315:Stress, Psychological / Q000150:complications* / Q000503:physiopathology
chemical_list: D011453:Prostaglandins; D012980:Sodium Salicylate; D007213:Indomethacin