Calcium and magnesium content of skeletal muscle. Studies in subjects undergoing diagnostic testing for malignant hyperthermia.
Ca2+ and Mg2+ contents were measured and compared among three different malignant hyperthermia susceptible (MHS) diagnostic groups. No difference was found among mean values for Ca2+ content, whereas Mg2+ content was greater in MHS muscle. Variance of measured values was unequal and greatest among MHS muscles, suggesting a possible abnormal distribution associated with MHS. Although more muscle fibres with Ca2+ less than or equal to 12 mumol g-1 were observed in MHS muscle, this difference was not statistically significant. In contrast, non-parametric analysis showed that the population of Mg2+ values was significantly greater in the MHS muscle. This study suggests that the distribution of Ca2+ and Mg2+ values is different in MHS muscle as a result of unknown genetic factors associated with the disease.
D002118:Calcium / Q000032:analysis*; D004198:Disease Susceptibility / Q000378:metabolism; D006801:Humans; D008274:Magnesium / Q000032:analysis*; D008305:Malignant Hyperthermia / Q000175:diagnosis / Q000378:metabolism*; D009132:Muscles / Q000032:analysis*
D008274:Magnesium; D002118:Calcium