title: Mathematical modelling of intra- and extracellular potentials generated by active structures: effects of a step change in structure diameter.
abstract: A mathematical model developed in our laboratory is used to estimate and analyse extracellular potentials generated in a volume conductor by a geometrically inhomogeneous structure with a step increase or a step decrease in its diameter. The transmembrane potentials were calculated using the model of Hodgkin and Huxley (1952) and the method of Joyner et al. (1978). Variations in waveforms of the transmembrane and extracellular potentials were described and discussed. Differences in waveforms of the extracellular potentials and in declines of their components are due to changes in the source which generates these potentials. In case of a propagation block the peak-to-peak amplitude of the extracellular potentials calculated over the area of the block may be higher than that over the area of propagation of action potentials. The possible applications of the results to the analysis of extracellular potentials recorded around actual motoneurons during their orthodromic or antidromic activation are discussed.
mesh_terms: D000200:Action Potentials; D008564:Membrane Potentials; D008954:Models, Biological; D008959:Models, Neurological; D009046:Motor Neurons / Q000502:physiology