[Determination of the neurotoxic esterase in neurologic pathology of toxic origin. Measurement in human lymphocytes in poisoning by organophosphates, ciguatera and ethyl alcohol].
Lymphocytic NTE activity was measured after intoxication by organo phosphorus compounds and in chronic alcoholics at the beginning of alcohol withdrawal. The results showed a rapid fall in lymphocytic NTE activity; neuropathy developed when the inhibition was 75 p. 100 or more. In chronic alcoholics, the fall in NTE activity is a new concept which must be taken into account when considering the causal factors of neurotoxicity in exposed professions and in patients taking potentially neurotoxic drugs. The NTE may be a useful parameter to demonstrate the toxic origin of chronic neuropathies, especially those caused by drugs. The capacity for lymphocytic NTE activity to return to normal seems to be different in acute, compared with chronic, intoxications.
D000208:Acute Disease; D000328:Adult; D000437:Alcoholism / Q000201:enzymology*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D002908:Chronic Disease; D036841:Ciguatera Poisoning; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D008387:Marine Toxins / Q000506:poisoning*; D009422:Nervous System Diseases / Q000139:chemically induced; D062025:Organophosphate Poisoning
D008387:Marine Toxins; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase
Détermination de la neurotoxic-estérase en pathologie neurologique d'origine toxique. Mesure sur lymphocytes humains au cours d'intoxications par organophosphates, ciguatera, alcool éthylique.