Tumor oxygenation using direct injection of oxygenated saline.
Direct injection of oxygen into an in-vivo tumor system was performed using saline lavage through a double-lumen catheter inserted into a Walker 256 carcinoma implanted in the flank of a rat. Ten extremely hypoxic tumors (core pO2 0 to 1 mm Hg) were examined. The mean pO2 in these tumors increased from 66 to 112 mm Hg after 5 minutes of lavage with oxygenated saline. These results indicate a substantial increase in tumor pO2 can be obtained with this system, possibly resulting in improved radioresponsiveness. More general applications of this system may also be feasible.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000532:radiotherapy / Q000628:therapy*; D010100:Oxygen / Q000627:therapeutic use*; D011836:Radiation Tolerance; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000627:therapeutic use*
D012965:Sodium Chloride; D010100:Oxygen