Analysis of intraocularly applied silicone oils of various origins.
Complications during the intraocular use of silicone oil can be caused by two factors: first, mechanical interaction with the surrounding tissue and, second, the physiochemical properties of the oil itself. The properties of 14 oils of various origins in clinical use were investigated: 12 of the 14 oils contained various amounts of low-molecular-weight components (cyclosiloxanes and molecules with a molecular weight of less than 2,400), which are able to diffuse into the surrounding tissue and may incite toxic or inflammatory reactions. Some of the samples had a ten-fold lower volume resistivity than others, an indicator of the presence of ionic impurities, such as catalyst remnants, which may also be responsible for adverse reactions.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004340:Drug Contamination; D005123:Eye; D006801:Humans; D007267:Injections; D007477:Ions; D008970:Molecular Weight; D012827:Silicone Oils; D014783:Viscosity; D014835:Volatilization
D007477:Ions; D012827:Silicone Oils