[The polymorphism of drugs in powders and tablets. 4. The effect of the polymorphism of drugs on the physical properties and drug release of phenobarbital tablets].
Four products of phenobarbital (I, II1, II2, III) are manufactured into tablets with the dry binders Avicel PH 101 or Heweten 40 using different pressures by direct tabletting. The physical properties of the resulting tablets are different according to the modification of phenobarbital, the binders used and the pressure during tabletting. The dissolution behaviour of the drug may be changed by the different technological and physical parameters.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D010634:Phenobarbital / Q000008:administration & dosage; D011208:Powders; D012995:Solubility; D013607:Tablets
D011208:Powders; D013607:Tablets; D010634:Phenobarbital
Untersuchungen zur Polymorphie von Arzneistoffen in Pulvern und Tabletten. 4. Mitteilung, Einfluss der Polymorphie des Wirkstoffes auf die physikalischen Eigenschaften und die Wirkstofffreigabe aus Phenobarbitaltabletten.