The protooncogene c-fos is transcriptionally active in normal human granulocytes.
Total cellular RNA of highly purified normal human blood cell populations was analyzed for the expression of the protooncogene c-fos, the cellular counterpart of the transforming FBJ virus. In marked contrast to previous findings based on in vitro studies with permanent leukemic cell lines, c-fos transcription was restricted to granulocytes. Neither blood monocytes nor blood lymphocytes or alveolar macrophages revealed detectable levels of c-fos transcription. Whereas this cellular oncogene is constitutively expressed in granulocytes, the monocytic cell line U-937 showed a transient c-fos transcription only after induction of differentiation. The contradiction between the results found in vivo and in vitro is discussed.
D001773:Blood Cells / Q000502:physiology; D002460:Cell Line; D005786:Gene Expression Regulation; D006098:Granulocytes / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D011519:Proto-Oncogenes; D012016:Reference Values; D014158:Transcription, Genetic; D014760:Viral Fusion Proteins / Q000378:metabolism
D014760:Viral Fusion Proteins