Blood coagulation abnormalities in Fischer strain rats bearing tumors.
This study reports an unusual subpopulation of rats bearing transplanted tumors approximately 50% of the total and apparently unrelated to the presence of metastases, that exhibited shortened bleeding times despite reduced platelet numbers and/or fibrinogen levels. The remaining rats exhibited the expected inverse relationships between bleeding time and platelet numbers and/or fibrinogen level. Tumors were hepatomas and squamous cell carcinomas initially induced in the Fischer strain of rats and carried by passage through tissue culture or syngenic recipient animals.
D000818:Animals; D001778:Blood Coagulation Disorders / Q000097:blood / Q000150:complications*; D002118:Calcium / Q000097:blood; D005340:Fibrinogen / Q000097:blood; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000150:complications; D009374:Neoplasms, Experimental / Q000097:blood / Q000150:complications*; D010976:Platelet Count; D011517:Prothrombin Time; D051381:Rats
D005340:Fibrinogen; D002118:Calcium