Twelve hour (trough) plasma nifedipine concentrations during chronic treatment with nifedipine retard.
Variation in plasma nifedipine concentrations have been reported and one study has suggested the existence of a subpopulation of poor metabolisers of this drug. We have studied the variability of 12 h plasma nifedipine concentrations in 64 hypertensive patients on long-term nifedipine Retard 20 mg twice daily. A slightly skewed unimodal distribution with a modal concentration of 15 to 30 ng/ml was obtained. No relationship between 12-h plasma levels and debrisoquine hydroxylation phenotype was found.
D000328:Adult; D000368:Aged; D003647:Debrisoquin / Q000378:metabolism; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000097:blood*
D003692:Delayed-Action Preparations; D009543:Nifedipine; D003647:Debrisoquin