title: Concurrent oral surgery and orthopaedic treatment in the multiply injured patient: is there an increased incidence of orthopaedic sepsis?
abstract: Fifty-five patients requiring oral surgery and orthopaedic care were studied prospectively and compared to a control group. Six patients received no antibiotics and one developed an orthopaedic operative site infection due to a mouth organism. Seventeen patients had concurrent surgery and perioperative antibiotic usage and no infections occurred. Twenty-six patients required multiple operations and courses of antibiotic treatment and five developed infections. Enterobacter infections were common and emerge because they are resistant to first-generation cephalosporins. Treatment by a perioperative first-generation cephalosporin is recommended, followed by throat cultures and treatment by antibiotics specific for cultured organisms for patients requiring subsequent operations.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000453:epidemiology*; D002511:Cephalosporins / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D004352:Drug Resistance, Microbial; D004754:Enterobacter / Q000187:drug effects; D004756:Enterobacteriaceae Infections / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009985:Orthopedics / Q000009:adverse effects; D011183:Postoperative Complications / Q000453:epidemiology*; D011292:Premedication; D013203:Staphylococcal Infections / Q000453:epidemiology; D013290:Streptococcal Infections / Q000453:epidemiology; D013515:Surgery, Oral / Q000009:adverse effects*; D013530:Surgical Wound Infection / Q000453:epidemiology*; D014947:Wounds and Injuries / Q000601:surgery*
chemical_list: D002511:Cephalosporins