Aldehyde dehydrogenase activities and NAD+-dependent formaldehyde oxidation in perivenous and periportal hepatocytes: effect of induction by beta-naphthoflavone.
The acinar distribution of aldehyde oxidizing capacity was studied by direct assay of rat hepatocytes prepared from either the periportal or the perivenous region. No significant zonation of low- or high-Km aldehyde dehydrogenase or formaldehyde oxidation was discerned. The induction of cytosolic aldehyde dehydrogenase by pretreatment with beta-naphthoflavone occurred to the same extent in both periportal and perivenous hepatocytes.
D000444:Aldehyde Dehydrogenase / Q000096:biosynthesis / Q000378:metabolism*; D000818:Animals; D001571:Benzoflavones / Q000494:pharmacology*; D003600:Cytosol / Q000201:enzymology; D004790:Enzyme Induction; D005419:Flavonoids / Q000494:pharmacology*; D005557:Formaldehyde / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008297:Male; D009243:NAD / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D019324:beta-Naphthoflavone
D001571:Benzoflavones; D005419:Flavonoids; D009243:NAD; D005557:Formaldehyde; D019324:beta-Naphthoflavone; D000444:Aldehyde Dehydrogenase