Therapy of spontaneously metastatic HSV-2 induced hamster tumours with cortisone acetate administered with or without heparin.
Subcutaneous injection of cortisone acetate administered with or without oral heparin retarded the growth of two HSV-2 induced hamster fibrosarcomas. Histological sections showed no obvious difference between the vasculature of treated and untreated tumours although there were fewer infiltrating lymphocytes in treated tumours. Treatment was, however, found to be ineffective against metastatic development following resection of primary tumours. Natural killer cell activity was found to be greatly reduced in animals receiving heparin and/or cortisone acetate treatment and this may influence the effectiveness of treatment on the metastatic process. We conclude that treatment of tumours with cortisone plus heparin is no different from the response to cortisone used alone.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002460:Cell Line; D003348:Cortisone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006224:Cricetinae; D004359:Drug Therapy, Combination; D005354:Fibrosarcoma / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D006493:Heparin / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000187:drug effects; D008297:Male; D008647:Mesocricetus; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D014412:Tumor Virus Infections / Q000188:drug therapy
D000970:Antineoplastic Agents; D006493:Heparin; D003348:Cortisone