The metabolism of 14C-labelled trimethylamine and its N-oxide in man.
The metabolism and elimination of 14C-labelled trimethylamine and its N-oxide (100 mg orally) were studied in three male volunteers. For both compounds the urine was the major route of elimination, with 95% of the administered 14C being voided in the first 24 h. No radioactivity was found in expired air. The majority (greater than 95%) of the urinary 14C from both compounds was excreted as trimethylamine N-oxide.
D001711:Biotransformation; D002855:Chromatography, Thin Layer; D006801:Humans; D007700:Kinetics; D008297:Male; D013058:Mass Spectrometry; D008744:Methylamines / Q000378:metabolism* / Q000652:urine
D008744:Methylamines; C005855:trimethyloxamine; C023336:trimethylamine