[Role of hydatidiform mole in the pathogenesis of choriocarcinoma].
Such pathogenetic patterns of choriocarcinoma (ChC) as development after normal and pathologic gestation are discussed. Clinically-based criteria of vesicular mole progression were established. It was found that 66.4 +/- 4.4% of cases did not need chemotherapy because removal of vesicular mole was invariably followed by cure. Therapy was indicated in 29.2 +/- 4.3% as symptoms continued to increase. Transition of untreated vesicular mole to ChC was recorded in 4.4 +/- 1.9% of cases. Timely adjuvant chemotherapy reduced relative risk of transformation to ChC 17.7 times.
D000328:Adult; D002822:Choriocarcinoma / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000150:complications* / Q000188:drug therapy; D011247:Pregnancy; D012306:Risk; D014594:Uterine Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control
Rol' puzyrnogo zanosa v patogeneze khoriokartsinomy.