title: Experimental studies in vitro and in vivo on the mutagenicity of flavoxate.
abstract: Flavoxate HCl is a drug with a remarkable smooth muscle relaxant activity, selective for the genito-urinary tract. In order to verify its safety the following mutagenic tests have been effected: gene reversion in S. typhimurium, gene conversion and crossing-over on S. cerevisiae 6117, micronucleus test and DNA-repair on B. subtilis. In our experimental conditions, flavoxate HCl was found to be devoid of potential mutagenic activity.
mesh_terms: D000818:Animals; D005419:Flavonoids / Q000633:toxicity*; D005422:Flavoxate / Q000633:toxicity*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens
chemical_list: D005419:Flavonoids; D009153:Mutagens; D005422:Flavoxate