[Effect of the bacterial polysaccharide pyrogenal on embryogenesis in noninbred white rats].
Pyrogenal was administered intramuscularly to albino rats in different terms of pregnancy in a single dose of 1000-1250 MTD/kg, twice with a 24-hour interval in a dose of 500-625 MTD/kg and repeatedly on 3rd-18th days of pregnancy in doses of 1.0-1.2, 5.0-6.3, 50.0-63.0 MTD/kg. Fetuses were studied on 20th day of pregnancy. Pyrogenal produced in embryos depending on the time of administration and dose congenital developmental defects, a decrease of body weight, thrombohemorrhagic syndrome, and erythrocytic hemolysis.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology*; D011247:Pregnancy; D011749:Pyrogens / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D008070:Lipopolysaccharides; D011749:Pyrogens; C009136:pyrogenal
Vliianie bakterial'nogo lipopolisakharida pirogenala na émbriogenez besporodnykh belykh krys.