[Clonogenic capacity, radiosensitivity and recovery from potentially lethal damage in individual subpopulations of the murine NKLy ascitic tumor].
Effectiveness of the diffusion chamber cloning of subpopulations of cells isolated by the sedimentation method from intact and exposed (5 Gy) mouse tumors NKLy was determined. It was shown that cells at the G2-M stages were highly radiosensitive. The recovery from potentially lethal damages was maximum at the G0-G1 stages of the cell cycle.
D000818:Animals; D002452:Cell Count / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D002999:Clone Cells / Q000378:metabolism / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair / Q000528:radiation effects*; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000528:radiation effects*; D007399:Interphase / Q000528:radiation effects; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D051379:Mice; D011836:Radiation Tolerance
D004273:DNA, Neoplasm
Klonogennaia sposobnost', radiochuvstvitel'nost' i voostanovlenie ot potentsial'no letal'nykh povrezhdeniĭ otdel'nykh subpopuliatsiĭ astsitnoĭ opukholi NKLy mysheĭ.