[Effect of pulmonary lipid peroxidation on the development of arterial hypoxemia in rats in the early posttraumatic period].
In experiments on rats it has been demonstrated that in the early post-traumatic period of chest contusion the appearance of respiratory insufficiency of the arterial-hypoxemia type is followed by increase of free-radical lipid peroxidation products of the lungs. To demonstrate the specific significance of these processes in decrease of PaO2 value is impossible, as submolecular changes in the lungs appear simultaneously with functional disorders. In the first week after trauma the mechanism of these processes in the normal parts of lungs is connected with activation of anabolic processes, but in the injured parts of lungs with activation of catabolic processes.
D000818:Animals; D003288:Contusions / Q000150:complications; D000860:Hypoxia / Q000209:etiology*; D008054:Lipid Peroxides / Q000096:biosynthesis*; D055370:Lung Injury; D008297:Male; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D012131:Respiratory Insufficiency / Q000209:etiology*; D013997:Time Factors
D008054:Lipid Peroxides; D011663:Pulmonary Surfactants
Vliianie perekisnogo okisleniia lipidov legkikh na formirovanie arterial'noĭ gipoksemii u krys v rannem posttravmaticheskom periode.