Effect of isoprinosine on haemopoietic stem cells (CFU) in bone marrow and spleen of mice.
Peroral application of Isoprinosine for 3, 5 and 10 days increases the number and proliferative activity of haemopoietic stem cells (CFUs) in the bone marrow of mice. Changes in the spleen occur later and are manifested by an increase in CFUs proliferative activity and by a transient decrease in CFUs number.
D000818:Animals; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D004906:Erythrocyte Count; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology
D007545:Isoproterenol