A strategy for reaching therapeutic salicylate levels in patients with rheumatoid arthritis using standardized dosing regimens.
After one to 2 weeks of 45 mg/kg/day choline magnesium trisalicylate (CMT) in 2 divided doses, 51 of 71 patients with rheumatoid arthritis (72%) had observed steady state serum salicylate concentrations between 150 and 300 mg/l (mean salicylate: 213 +/- 10 mg/l), although 17 later required dose adjustment. CMT dosing was changed in 37 cases by using the formula: dosing rate = total clearance X concentration. The expected and observed concentrations were not different (p = 0.31); thus, this formula can help calculate salicylate dosing changes to bring the serum salicylate level to within the therapeutic range.
D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000188:drug therapy; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012459:Salicylates / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D020156:Salicylic Acid
D012459:Salicylates; D020156:Salicylic Acid