Alterations of secretory pattern of intestinal lipoproteins by the benzoyl ester derivative of poloxalene surfactant (BEP).
Hydrophobic surfactant BEP was administered intraduodenally as part of lipid emulsion to rats with cannulated mesenteric lymphatic duct. The effect on the size and composition of intestinal triglyceride-rich lipoproteins (TRLp) was assessed by comparing the results with those obtained during infusion of the lipid emulsion alone. Administration of BEP decreased intestinal capacity to transport triglyceride and cholesterol in large TRLp, SF greater than 2000, and resulted in a significant reduction of total triglyceride in lymph. Non-apoB apolipoproteins decreased significantly in large and increased in small TRLp without appreciable change in total content. Contrary to these findings total apoB protein content increased significantly, primarily due to an increase in small TRLp. Changes in lipid and protein content of apolipoproteins produced by BEP resulted in increased ratios of apolipoproteins to lipids in TRLp. It was therefore concluded that inhibition of lipid transport by BEP was not a result of apolipoprotein deficiency. Discontinuation of BEP administration resulted in a prompt recovery of the intestinal lipid transport system.
D000818:Animals; D002914:Chylomicrons / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D008074:Lipoproteins / Q000378:metabolism*; D008297:Male; D011060:Poloxalene / Q000031:analogs & derivatives / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002914:Chylomicrons; D008074:Lipoproteins; D011092:Polyethylene Glycols; C052741:poloxalene benzoyl ester; D011060:Poloxalene