Age- and sex-related induction of excessive grooming and "wet-dog" shakes by the codeinone RX 336-M in the rat.
Peripheral administration of the dihydrocodeinone RX 336-M (6 mg/kg) stimulated vigorous "wet-dog" shakes and excessive grooming in young drug-naive rats. The effects of RX 336-M were greater in younger than in older animals of both sexes, and were greater in 39-day-old male rats than in female rats of the same age. In a second experiment, female rats were pretreated with testosterone benzoate (1 mg/kg/day) for 1 week prior to testing the effects of RX 336-M at 39 days of age. The sex hormone pretreatment enhanced the ability to RX 336-M to induce "wet-dog" shakes and excessive grooming in female rats. The results suggest that both sex- and hormone-dependent developmental status are critical in the display of the so-called "quasi-morphine withdrawal syndrome." The results imply, and are consistent with previous studies which suggest, that different neural mechanisms underlie the behavioral responses induced by ACTH and RX 336-M.
D000367:Age Factors; D000818:Animals; D003061:Codeine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006120:Grooming / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013239:Stereotyped Behavior / Q000187:drug effects*
D009292:Narcotic Antagonists; C006086:RX 336M; D003061:Codeine