Analysis of serum concentration of phenobarbital, phenytoin, carbamazepine and carbamazepine 10,11-epoxide by solvent-recycled liquid chromatography.
A rapid and precise low cost method for analysing phenobarbital, phenytoin, carbamazepine and carbamazepine 10,11-epoxide using liquid chromatography is described. Recycling reduced the mobile phase consumption by 75%. Recovery was 97.7-101.4% and between days CV was 1.3-1.7%. The retention times of potentially interfering substances are listed.
D002220:Carbamazepine / Q000031:analogs & derivatives / Q000097:blood*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D010634:Phenobarbital / Q000097:blood*; D010672:Phenytoin / Q000097:blood*
D002220:Carbamazepine; D010672:Phenytoin; C012227:carbamazepine epoxide; D010634:Phenobarbital