Acquisition of a brief behavioral experience in the presence of neuron-specific and D2-CAM/N-CAM-specific antisera.
The effect of intraventricular infusion of D2-CAM/N-CAM directed antibodies prior to the acquisition of a passive-avoidance paradigm is described. The antisera used in this study were the neuron specific anti-BPM and a D2-CAM/N-CAM specific serum, anti-D2. Anti-BPM reliably inhibited paradigm acquisition when recall was ascertained at 24 and 48 hours and no effect was noted with absorbed anti-BPM or in sham-operated animals. This effect was time-dependent and no inhibition of memory formation was noted when the antiserum was administered at 6 and 10 hours after training. In contrast, infusion of anti-D2 had no effect on paradigm acquisition. These findings are discussed in relation to the potential synaptogenic events associated with memory formation.
D000818:Animals; D000954:Antigens, Surface / Q000502:physiology*; D001362:Avoidance Learning / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D015815:Cell Adhesion Molecules; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009473:Neuronal Plasticity; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000502:physiology*
D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D009419:Nerve Tissue Proteins; C023513:brain-specific protein D2, rat