Membrane currents in adult rat superior cervical ganglia in dissociated tissue culture.
Intracellular and whole-cell recordings were made from young adult superior cervical ganglion neurones maintained in dissociated tissue culture. The neurones possessed an M-current, A-current and calcium-activated potassium currents in addition to inward sodium and calcium currents. The properties of these currents closely resembled those observed in intact sympathetic ganglia. In contrast to neurones cultured from foetal tissue, these adult cultures exhibited consistent responses to nicotinic agonists.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D046508:Culture Techniques; D004594:Electrophysiology; D005728:Ganglia, Sympathetic / Q000502:physiology*; D008564:Membrane Potentials; D009474:Neurons / Q000502:physiology; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D012964:Sodium; D011188:Potassium; D002118:Calcium