Effect of low-dose dopamine on kidney function and vasoactive hormones in pediatric patients with advanced renal failure.
Dopamine (DA) was infused in a dose of 2 micrograms/kg/min in 12 children and adolescents with chronic renal failure to test the vasodilatory reserve capacity of the kidney. Mean basal GFR and ERPF were 17.8 and 93.1 ml/min/1.73 m2, respectively. DA infusion had no significant influence on GFR but effective renal plasma flow (ERPF) increased by 14% (p less than 0.05). After DA, GFR did not correlate with ERPF. There was a significant increase in urinary sodium excretion (+22%). Sodium excretion correlated with osmotic clearance and urine flow rate with free water clearance. Plasma prolactin concentration was decreased (p less than 0.01), whereas noradrenaline, adrenaline and free dopamine increased significantly after DA. Plasma renin activity, aldosterone, arginine vasopressin and atrial natriuretic peptide levels remained unchanged. The data indicate that in pediatric patients with advanced renal failure DA fails to increase filtration capacity, whereas effective renal plasma flow and sodium excretion are stimulated. It is speculated that in this situation preglomerular and tubular renal functions regulated by dopamine receptors are better conserved than those affecting glomerular microcirculation.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004298:Dopamine / Q000627:therapeutic use*; D005919:Glomerular Filtration Rate; D006439:Hemodynamics / Q000187:drug effects; D006728:Hormones / Q000097:blood*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000503:physiopathology; D009318:Natriuresis / Q000187:drug effects; D012079:Renal Circulation / Q000187:drug effects
D006728:Hormones; D004298:Dopamine