Human retroviral sequences on the Y chromosome.
Novel endogenous human retroviral sequences were cloned by low-stringency hybridization, using the pol gene of endogenous human retrovirus 51-1. One clone, lambda NP-2, contained gag, pol, env, and long terminal repeat sequences related to the corresponding portions of clone 51-1 and the closely related full-length endogenous human retrovirus 4-1. The sequence of the env gene of NP-2 was 73% homologous to that of 4-1. Genomic Southern blots of male and female DNAs showed that NP-2 is located on the Y chromosome and that the Y chromosome also contains one other sequence closely related to the env and 3' flanking regions of NP-2. Conservation of flanking DNA suggests that the second Y chromosome copy of the NP-2 env sequence arose by gene duplication rather than provirus insertion.
D001483:Base Sequence; D003001:Cloning, Molecular; D005796:Genes; D005814:Genes, Viral; D006801:Humans; D009693:Nucleic Acid Hybridization; D012190:Retroviridae / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics; D014998:Y Chromosome
D014764:Viral Proteins