Spontaneous alternation and habituation in Purkinje cell degeneration mutant mice.
Purkinje cell degeneration (pcd) mutant mice were found to be as active as normal mice in a T-maze. The pcd mutants, contrary to normal mice, did not alternate spontaneously in either a 2-trial or a 4-trial test. Results are discussed in terms of a role for the cerebellum in behavioral inhibition and visuo-spatial organization.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D051379:Mice; D008818:Mice, Neurologic Mutants; D009043:Motor Activity / Q000502:physiology; D011689:Purkinje Cells / Q000502:physiology*; D013037:Spatial Behavior / Q000502:physiology