The effect of a single oral dose of ethanol on hepatic blood flow in man.
The magnitude and time course of changes in hepatic blood flow following oral ingestion of a single (0.6 g/kg) dose of ethanol was studied using the model compound indocyanine green (ICG). Hepatic blood flow was not significantly different at 40, 90, 150 and 210 minutes following ethanol as compared to baseline values measured 20 and 70 min prior to alcohol ingestion. These results suggest that ethanol, at concentrations commonly associated with social drinking, has minimal effects on liver blood flow and would be expected to contribute little to changes in either the bioavailability or clearance of drugs highly extracted by the liver.
D000284:Administration, Oral; D000328:Adult; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007208:Indocyanine Green; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male; D013997:Time Factors
D000431:Ethanol; D007208:Indocyanine Green