Comparative study on the effects of a low molecular weight heparin (CY 216) and standard heparin in low dosage on experimental venous thrombosis.
In a venous thrombosis model in the rat obtained by ligation of the inferior vena cava, the effects of standard heparin and CY 216, a low molecular weight heparin fraction, are compared. At a dosage of less than 2 mg/kg b.w. CY 216 is an effective antithrombotic, whereas standard heparin is not.
D000818:Animals; D004195:Disease Models, Animal; D005170:Factor X / Q000037:antagonists & inhibitors; D015951:Factor Xa; D006493:Heparin / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D010314:Partial Thromboplastin Time; D051381:Rats; D011919:Rats, Inbred Strains; D013918:Thrombin Time; D013924:Thrombophlebitis / Q000188:drug therapy*; D014682:Vena Cava, Inferior
D005170:Factor X; D006493:Heparin; D015951:Factor Xa