[The polymorphism of drugs in powders and tablets. 1. The preparation and characterization of polymorphic modifications of phenobarbital].
The characterisation of three phenobarbital modifications by thermic examination procedures (DSC, DTA) is being described. Modification I was obtained by thermic treatment of the brands (modification II) from Hungary and the GDR. The spray product prepared, consisting of very fine hollow spheres, was identified as modification III. Besides the particle size distribution the form of the particle was determined by scanning electron microscopy (REM). The best results regarding saturation solubility and speed of dissolution were found for the spray product.
D002626:Chemistry, Pharmaceutical; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D010634:Phenobarbital / Q000032:analysis*; D011208:Powders; D013607:Tablets
D011208:Powders; D013607:Tablets; D010634:Phenobarbital
Untersuchungen zur Polymorphie von Arzneistoffen in Pulvern und Tabletten. 1. Mitteilung: Zur Herstellung und Charakterisierung polymorpher Modifikationen des Phenobarbitals.