title: Malabsorption associated with nonmalignant immunoproliferative small intestinal disease.
abstract: Two cases of nonmalignant immunoproliferative small intestinal disease (IPSID) presenting with severe malabsorption are described. The first patient had a lymphocytic infiltrate of the lamina propria and lymphoid hyperplasia of the mesenteric lymph nodes and responded to oral tetracycline. The second patient had a polyclonal plasmacytic infiltration of the lamina propria and of the mesenteric nodes and responded only to cytotoxic treatment with cyclophosphamide. These cases represent examples of non-alpha-chain disease benign IPSID.
mesh_terms: D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007161:Immunoproliferative Small Intestinal Disease / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D007583:Jejunum / Q000473:pathology; D008286:Malabsorption Syndromes / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013752:Tetracycline / Q000627:therapeutic use
chemical_list: D003520:Cyclophosphamide; D013752:Tetracycline