Effect of corticosteroids on the toxic pulmonary oedema induced by nitrogen dioxide inhalation in the rat.
Various corticoid derivatives administered by inhalation or intraperitoneally were investigated for a preventive effect on the pulmonary oedema of the rat induced by the 30-min inhalation of 100-105 ppm NO2. After inhalational administration in the form of an aqueous aerosol, dexamethasone-21-isonicotinate showed a considerably greater efficacy than beclomethasone-17,21-dipropionate or dexamethasone-21-dihydrogen phosphate. With prophylactic intraperitoneal administration dexamethasone (free alcohol), dexamethasone-21-dihydrogen phosphate and 6 alpha-methylprednisolone-21-dihydrogen succinate had to be given in much higher doses than dexamethasone-21-isonicotinate to achieve the same effects on the toxic pulmonary oedema.
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D000336:Aerosols; D000818:Animals; D005260:Female; D007274:Injections, Intraperitoneal; D009585:Nitrogen Dioxide; D011654:Pulmonary Edema / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains
D000305:Adrenal Cortex Hormones; D000336:Aerosols; D009585:Nitrogen Dioxide