title: Regional variations in the extent and timing of motoneuron cell death in the lumbosacral spinal cord of the chick embryo.
abstract: We have examined the distribution of motoneurons in different segments of the chick lumbosacral spinal cord before and after the period of motoneuron cell death. The extent of cell death was found to be greatest at the boundaries of the lumbosacral cord where over 60% of the motoneurons died and least in the central region where only 30% died. After cell death at stage 40 the number of motoneurons in each segment was linearly correlated with segment length, suggesting that growth of the segment and motoneuron numbers may be regulated by a common factor. The time of completion of motoneuron cell death exhibited a rostrocaudal gradient along the lumbar cord. Cell death was complete in the anterior segments by stage 35 but not until stage 38 in the caudal 4 segments. The regional variations in the extent and timing of motoneuron cell death suggest that the relative importance of the factors mediating cell death vary in different regions of the lumbar cord.
mesh_terms: D000818:Animals; D002470:Cell Survival; D002642:Chick Embryo; D009046:Motor Neurons / Q000166:cytology*; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology*