[Comparative evaluation of the hypoglycemic activity of the vegetal complex of Phaseolus vulgaris and chlorpropamide in experimental diabetes].
Experiments on rabbits with alloxan diabetes showed that the plant complex (PC) reduced the level of glycemia after single administration for 6-8 h by 27-32%. A similar effect was demonstrated with chlorpropamide. However the PC produced a longer hypoglycemic effect. In course treatment the PC returned the blood level of glucose (5.14 +/- 0.62 mmol/l) to normal on the 11th day whereas with chlorpropamide this indicator was almost normal (6.6 +/- 1.1 mmol/l) on the 15th day only. A rapid decrease in the blood glucose concentration caused by the PC was observed in AIS induced hyperglycemia. The PC demonstrated its sugar reducing action by extrapancreatic means.
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002682:Chinchilla; D002747:Chlorpropamide / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D007887:Fabaceae; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan; D002747:Chlorpropamide
Sravnitel'naia otsenka gipoglikemicheskoĭ aktivnosti rastitel'nogo kompleksa iz fasoli obyknovennoĭ i khlorpropamida pri éksperimental'nom diabete.