Two different quadruplicated alpha globin gene arrangements.
The discovery of two different types of alpha globin gene quadruplication is reported. One with the alpha alpha alpha alpha (anti 3.7)/haplotype was present in four members of a Black family from Georgia, while a second with the alpha alpha alpha alpha (anti 4.2)/haplotype was observed in two members of an Indonesian family. Consistent clinical and haematological manifestations could be observed in these heterozygotes.
D000328:Adult; D002675:Child, Preschool; D002874:Chromosome Mapping; D003434:Crossing Over, Genetic; D005260:Female; D005914:Globins / Q000235:genetics*; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D013789:Thalassemia / Q000235:genetics
D005914:Globins