Pulmonary response to atmospheric pollutants. 3. The role of pulmonary collapse in the induction of aberrations of the type 2 pneumocyte.
Type 2 pneumocyte responses were studied in the rat after experimental right apical lobe collapse induced by surgical occlusion of the apical bronchus. After initial degranulation, type 2 pneumocytes underwent proliferation, and exhibited large numbers of well formed and densely staining intracytoplasmic surfactant lamellar bodies. The proliferative response, which was diffuse in the initial 3 to 25 days, became focal by 50 days and thereafter subsided. These results are discussed in relationship to the responses of the type 2 pneumocyte to toxic injury as previously reported.
D000393:Air Pollutants / Q000009:adverse effects*; D000818:Animals; D005260:Female; D008168:Lung / Q000187:drug effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains
D000393:Air Pollutants