Elevation of bilirubin production in neonatal rats treated with nicardipine hydrochloride.
Administration of nicardipine hydrochloride, a dihydropyridine calcium entry blocker, caused a 30% rise in the rate of bilirubin formation in neonatal rats. Plasma bilirubin concentrations also increased from 0.83 +/- 0.05 to 1.06 +/- 0.10 mg/100 ml (p less than 0.05). We conclude that maternal administration of nicardipine hydrochloride for tocolysis could affect bilirubin production in the neonate.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001663:Bilirubin / Q000097:blood / Q000378:metabolism*; D002248:Carbon Monoxide; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009529:Nicardipine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002248:Carbon Monoxide; D009529:Nicardipine; D006419:Heme Oxygenase (Decyclizing); D001663:Bilirubin