Corticosteroids-salicylate interaction in a case of juvenile rheumatoid arthritis.
In an 11-year-old child with juvenile rheumatoid arthritis (JRA), the addition of prednisone caused a significant decrease in salicylate serum concentrations. A pharmacokinetic assessment suggested that these changes were not the result of altered compliance or impaired absorption of salicylate but rather an increase in salicylate clearance induced by the corticosteroid.
D001171:Arthritis, Juvenile / Q000188:drug therapy*; D001241:Aspirin / Q000008:administration & dosage / Q000378:metabolism; D002648:Child; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D007700:Kinetics; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000494:pharmacology*; D012459:Salicylates / Q000378:metabolism*
D012459:Salicylates; D001241:Aspirin; D011241:Prednisone