[Dilution of the toxic action of 5-fluorouracil on the mucosa of the small intestine in mice using the sap of plantain].
The study was concerned with an attempt at reducing the acute toxic effect of 5-fluorouracil (5-FU) on gut mucosa in mice with Ehrlich ascites tumors. An official preparation of plantain sap was shown to ward off this effect and to contribute to the normalising of certain parameters of epithelial cells. The DNA level of tumor cells showed a more drastic decline after combined treatment with 5-FU and the preparation than after the cytostatic drug alone.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D005472:Fluorouracil / Q000627:therapeutic use / Q000633:toxicity*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D007583:Jejunum / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009368:Neoplasm Transplantation; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D010943:Plantago; D010946:Plants, Medicinal; D013997:Time Factors
D010936:Plant Extracts; D005472:Fluorouracil
Oslablenie toksicheskogo deĭstviia 5-ftoruratsila na slizistuiu obolochku tonkoĭ kishki mysheĭ sokom podorozhnika.