[Determination of the concentrations of niflumic acid in the plasma and synovial tissue following repeated administration of capsules].
Niflumic acid was assayed in the plasma and synovial tissue of 12 adults about 10 hours following the end of a 1 g niflumic acid daily administration for 2 days; an arthroscopy of the knee had been carried out in these patients with various degenerative infections. The ratio of niflumic acid synovial concentrations to plasmatic concentrations was 1.27, showing the affinity of this drug for the synovial tissue.
D000284:Administration, Oral; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D006801:Humans; D009539:Nicotinic Acids / Q000378:metabolism*; D009544:Niflumic Acid / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D013583:Synovial Membrane / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009539:Nicotinic Acids; D009544:Niflumic Acid
Détermination des concentrations d'acide niflumique dans le plasma et le tissu synovial après administration répétée de gélules.