[Dissociative state in rats induced by ethanol and possibilities of the pharmacological correction of this phenomenon].
It was shown that a state of dependent learning (SDL) developed in response to ethanol (1.2 g/kg) during experimental learning of rats in conditions of T-maze. Piracetam, lithium hydroxybutyrate, litonit and new oxypyridine derivative 3-OP given in combination with ethanol prevented the development of SDL and reduced an already formed SDL. The above-mentioned combinations made the learning more difficult. It is assumed that changes in the activity of dopaminergic system, as well as membranotropic and antioxidant effects of the investigated drugs play the most important role in the mechanisms of SDL reduction.
D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001245:Association Learning / Q000187:drug effects / Q000502:physiology*; D006885:Hydroxybutyrates / Q000494:pharmacology; D007858:Learning / Q000502:physiology*; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology; D009942:Organometallic Compounds / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D014149:Tranquilizing Agents / Q000494:pharmacology*
D000975:Antioxidants; D006885:Hydroxybutyrates; D009539:Nicotinic Acids; D009942:Organometallic Compounds; D011725:Pyridines; D014149:Tranquilizing Agents; C023500:3-hydroxypyridine; C022826:lithium hydroxybutyrate; C041554:litonit; D010889:Piracetam
"Dissotsiirovannoe sostoianie" u krys, vyzvannoe étanolom, i vozmozhnosti farmakologicheskoĭ korrektsii dannogo fenomena [correction of fermenta].