The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani.
Several alkyl phosphorylcholines and related derivatives were tested against Leishmania donovani amastigotes in mouse peritoneal macrophages in vitro and ED50 values were determined in the range of 1-12 microM. The three alkyl phosphorylcholines tested against L. donovani in BALB/c mice were active, an ED50 of 12.8 mg/kg/day X 5 was ascertained for one compound, but an alkyl phosphorylethanolamine was inactive.
D000478:Alkylation; D000818:Animals; D002794:Choline / Q000031:analogs & derivatives*; D007893:Leishmania donovani / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D010767:Phosphorylcholine; D002794:Choline