Toxicity of chloroform and bromodichloromethane when administered over a lifetime in rats.
Chloroform (CHCl3) and bromodichloromethane (CHBrCl2) are the two most common haloorganic contaminants of chlorinated drinking water. A significantly increased incidence of hepatic neoplastic nodules was found in female rats when either of these compounds was administered in drinking water to Wistar rats throughout their life-span. Hepatic adenofibrosis was also produced by chronic ingestion of these two halomethanes.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D002460:Cell Line; D002725:Chloroform / Q000633:toxicity*; D005260:Female; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D008297:Male; D009374:Neoplasms, Experimental / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D022882:Trihalomethanes
D002273:Carcinogens; D006846:Hydrocarbons, Halogenated; D022882:Trihalomethanes; C025191:bromodichloromethane; D002725:Chloroform