[Magnesium hydroxide treatment of hyperphosphatemia in chronic hemodialysis patients with an aluminum overload].
The control of hyperphosphatemia in dialysis patients is frequently achieved using aluminium hydroxide (A1(OH)3) and/or calcium carbonate (Ca CO3). However, this effect is counterbalanced by risk of aluminium intoxication and hypercalcemia. An alternative to the use of these phosphate binders is the prescription of magnesium hydroxide (Mg(OH)2) in association with a magnesium free dialysate. 19 patients with subtoxic plasma aluminium concentration received such a therapy. 9 months after starting the essay 4 patients had been excluded for digestive intolerance (3 cases) and neuro-psychic symptoms related to hypermagnesemia (1 case) after therapy with maximal doses of 6 to 12 g/d. Plasma inorganic phosphorus was decreased from 2.47 +/- 0.32 to 1.86 +/- 0.40 mmol/l (P less than 0.05) and plasma aluminium from 3.03 +/- 0.93 to 1.52 +/- 0.15 mumol/l (P less than 0.05). The results have been obtained without any significant increase in plasma and red cell magnesium levels. Metabolic alkalosis has been observed in association with the increase of ion exchange resin (sodium polystyrene sulfonate: Kayexalate) to treat progressive hyperkalemia. With the exception of possible metabolic effects occurring on a long term basis, Mg(OH)2 in association with magnesium-free dialysate seems of value to treat dialysis hyperphosphatemia.
D000328:Adult; D000368:Aged; D000536:Aluminum Hydroxide / Q000097:blood / Q000506:poisoning*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D008274:Magnesium / Q000627:therapeutic use*; D008276:Magnesium Hydroxide / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood* / Q000378:metabolism; D006435:Renal Dialysis / Q000009:adverse effects*
D010710:Phosphates; D000536:Aluminum Hydroxide; D008274:Magnesium; D008276:Magnesium Hydroxide
Traitement par l'hydroxyde de magnésium de l'hyperphosphorémie des hémodialysés chroniques ayant une surcharge en aluminium.