[Effect of hydrocortisone on the behavior of mediators of the adrenergic system (dopamine, noradrenaline and homovanillic acid) in the liver during experimental endotoxic shock].
The influence of hydrocortisone on the behaviour of the concentration of dopamine (DA), noradrenaline (NA), and homovanillic acid (HVA) were estimated in liver homogenates in the course of the experimental endotoxic shock. The concentration of DA and NA decrease in untreated animals in the 2nd and 4th hour in order to increase significantly in the 6th hour. The concentration of the HVA also increased in the 6th hour after a transitory significant decrease. - The values in the treated animals were in case of DA increased in the 2nd and 4th hour and decreased significantly in the 6th hour. In case of NA they decreased in the 2nd and 4th and increased significantly in the 6th hour and the values for HVA increased significantly in the whole time. The favourable effect of the hydrocortisone in the treated group can be traced back to the increased DA concentration, the decreased NA concentration and the better utilization of the DA by the tissue. This increased HVA could be evidence for them.
D000818:Animals; D004285:Dogs; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D012772:Shock, Septic / Q000378:metabolism*
D004298:Dopamine; D006854:Hydrocortisone; D009638:Norepinephrine; D006719:Homovanillic Acid
Einfluss des Hydrokortisons auf das Verhalten der Mediatoren des adrenergischen Systems (Dopamin, Noradrenalin und Homovanillinsäure) in der Leber im Verlauf des experimentellen Endotoxinschocks.