Local treatment of candidal vaginitis with a mepartricin-sodium lauryl sulfate complex.
44 patients with candidal vaginitis participated in a trial using a new formulation of a mepartricin-sodium lauryl sulfate complex for local administration (dosage schedule: one 25,000-unit vaginal tablet (SPA-S-222) daily for 6 days). Microbiological examination revealed an 88.6% cure rate (samples tested negative) at the end of treatment and a 90.9% cure rate 30 days after cessation of treatment. In addition, the clinical symptoms observed at the beginning of treatment disappeared rapidly and the patients showed great clinical improvement under the present therapy. Both local and systemic tolerance of the preparation used were excellent.
D000282:Administration, Intravaginal; D000328:Adult; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D008613:Mepartricin / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011090:Polyenes / Q000627:therapeutic use*; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage / Q000627:therapeutic use*
D011090:Polyenes; D008613:Mepartricin; D012967:Sodium Dodecyl Sulfate