Bactericidal properties of an organic N-chloramine formed in situ.
Agent I (3-chloro-4,4-dimethyl-2-oxazolidinone) formed in situ was compared with pre-formed agent I as a disinfectant against Staphylococcus aureus. In situ formation involved combining the non-chlorinated oxazolidinone precursor with calcium hypochlorite to form 5 and 10 mg/l total chlorine concentrations of agent I. The variables included in the study were temperature, pH and concentration. Overall the bacteria were killed more rapidly at 22 degrees than at 4 degrees C. The in situ formation appeared to occur most rapidly at pH 7.0, slightly slower at pH 9.5, and very slowly at pH 4.5 as evidenced by the presence of residual free chlorine. In the in situ experimental runs the 5 and 10 mg/l concentrations were equally effective in obtaining a six log decline in cfu/ml. This study indicates the potential for using the organic N-chloramine as a general purpose disinfectant while omitting the laboratory synthesis of the final product.
D055598:Chemical Phenomena; D002621:Chemistry; D004202:Disinfectants / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D010080:Oxazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D023303:Oxazolidinones; D013211:Staphylococcus aureus / Q000187:drug effects*; D013696:Temperature
D004202:Disinfectants; D010080:Oxazoles; D023303:Oxazolidinones; C036350:3-chloro-4,4-dimethyl-2-oxazolidinone