A new immunomodulator, FR-900494: taxonomy, fermentation, isolation, and physico-chemical and biological characteristics.
FR-900494 is a new type of immunoactive substances produced by an actinomycete named Kitasatosporia kifunense sp. nov. FR-900494 exhibits a competitive action against immunosuppressive factor produced in the serum of tumor bearing mice and has the capacity to restore the depression of lymphocytes.
D000192:Actinomycetales / Q000032:analysis* / Q000166:cytology / Q000502:physiology; D000276:Adjuvants, Immunologic / Q000302:isolation & purification*; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D050260:Carbohydrate Metabolism; D002473:Cell Wall / Q000032:analysis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003470:Culture Media; D003960:Diaminopimelic Acid / Q000032:analysis; D007165:Immunosuppression Therapy; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D013056:Spectrophotometry, Ultraviolet
D000276:Adjuvants, Immunologic; D000596:Amino Acids; D003470:Culture Media; D003960:Diaminopimelic Acid