Reduced platelet phenylalanine hydroxylating activity in a subgroup of untreated schizophrenics.
Considering that platelet phenylalanine hydroxylase represents a rather high percentage of the total body hydroxylating activity, the encountered deficiency may very well be considered as one of the exacerbing factors of psychosis of this type. Further biochemical and clinical characterization of the described subgroup is in progress.
D001792:Blood Platelets / Q000378:metabolism*; D003866:Depressive Disorder / Q000097:blood; D006801:Humans; D010651:Phenylalanine Hydroxylase / Q000097:blood*; D012563:Schizophrenia, Paranoid / Q000097:blood*; D014443:Tyrosine / Q000097:blood*
D014443:Tyrosine; D010651:Phenylalanine Hydroxylase