title: Natural history of chronic hepatitis B virus-related liver disease and its relationship to serum markers of viral replication.
abstract: Our understanding of the process whereby replicating Hepatitis B virus is eradicated has been substantially modified by the development of highly sensitive assays of viral replication, such as the detection of HBV-DNA in serum. The implications of these developments on our therapeutic approach in terms of both timing and expectations is discussed.
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D004279:DNA, Viral / Q000097:blood*; D006509:Hepatitis B / Q000175:diagnosis* / Q000188:drug therapy; D006515:Hepatitis B virus / Q000235:genetics*; D006521:Hepatitis, Chronic / Q000175:diagnosis*; D006801:Humans; D013997:Time Factors; D014779:Virus Replication
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral