Effect of prednisolone on theophylline pharmacokinetics in patients with chronic airflow obstruction.
The effect of prednisolone on the elimination kinetics of theophylline was studied in a group of nine patients with chronic airflow obstruction. Volume of distribution, plasma half life, and clearance after a single intravenous dose of aminophylline (5.6 mg/kg) were unchanged by prednisolone treatment (20 mg daily for three weeks). The metabolism of an intravenous bolus of theophylline is not influenced by oral prednisolone.
D000368:Aged; D000628:Aminophylline / Q000627:therapeutic use; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000494:pharmacology*; D013806:Theophylline / Q000378:metabolism* / Q000627:therapeutic use
D000628:Aminophylline; D011239:Prednisolone; D013806:Theophylline