[The relationship between dysplasia and squamous cell carcinoma of the esophagus and the consumption of alcohol and tobacco].
Forty-nine cases of esophagectomy and 242 autopsied cases were studied to delineate the pattern of the genesis of esophageal carcinoma. Severe dysplastic lesions found to be commonly associated with carcinoma of the esophagus, but with the exception of one case, these lesions were not associated with other carcinomas. They were more frequent in the cases of multiple primary cancer. This suggests that squamous carcinoma of the esophagus develops from severe dysplasia in a very similar manner to a carcinoma of the cervix uteri. Almost all cases of multiple primary cancers of the oropharynx and the esophagus had a history of heavy smoking and alcoholic drinking habits; so, in some manner, alcohol and tobacco consumption appear to increase the susceptibility of the squamous mucosa to a malignant transformation.
D000368:Aged; D000428:Alcohol Drinking; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000473:pathology*; D004947:Esophagus / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D012907:Smoking