Platelet monoamine oxidase and plasma dopamine-beta-hydroxylase activities in non-abstinent chronic alcoholics. Relation to clinical parameters.
Platelet monoamine oxidase (MAO) and plasma dopamine-beta-hydroxylase (DBH) activities were determined in 27 male non-abstinent chronic alcoholics. Compared to 24 normals, no significant difference in both enzyme activities was found. Alcoholics with at least one alcoholic first degree relative had a trend toward lower platelet MAO activity compared to those without such a history. Matched pair analysis showed that alcoholics of the former subgroup had significantly lower MAO activity than controls. Demented alcoholics had significantly reduced plasma DBH activity compared with the non-demented subgroup and with age, and sex, matched controls.
D000328:Adult; D000437:Alcoholism / Q000201:enzymology* / Q000523:psychology; D001792:Blood Platelets / Q000201:enzymology*; D003704:Dementia / Q000201:enzymology; D004299:Dopamine beta-Hydroxylase / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D012044:Regression Analysis
D004299:Dopamine beta-Hydroxylase; D008995:Monoamine Oxidase