Genetic relationship between a lymphocyte membrane abnormality and blood pressure in spontaneously hypertensive stroke prone and Wistar-Kyoto rats.
The fluxes of sodium and potassium across the lymphocyte membrane in spontaneously hypertensive, stroke prone rats (SHRSP) are greater than those in Wistar-Kyoto rats (WKY). In order to define the relationship of these abnormal membrane traits to arterial pressure elevation, their distributions were studied in F1, F2, and backcross progeny of the cross of SHRSP and WKY rats. In the F1 generation, arterial pressure and potassium efflux values resembled those of the WKY parents suggesting that these traits are dominant in the normotensive rat; sodium influx values resembled those of the SHRSP parents. There was poor correlation (r = 0.45) between blood pressure and sodium influx in the F2 generation. There was a high correlation between blood pressure and potassium efflux (r = 0.86), suggesting that these two traits may be under the control of a common genetic mechanism.
D000818:Animals; D001692:Biological Transport; D001794:Blood Pressure; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D011188:Potassium / Q000097:blood*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012964:Sodium / Q000097:blood*
D012964:Sodium; D011188:Potassium