[Growth and metastasis of Lewis' lung carcinoma in mice under the pharmacological action on metabolism and the effects of kinins].
In experiments on C57 Bl mice the effects of growth and metastatic proliferation of Lewis lung carcinoma inoculated intramuscularly on metabolism and kinin activity have been studied during the application of pharmacologic agents (parmidin, cellulose sulphate, unithiol). Causing a weak inhibition of the primary tumour growth, parmidin if administered repeatedly in given doses, inhibits partially metastatic process, which is manifested in an essential decrease of the quantity, size and weight of lung metastases. Parmidin also inhibits an adverse effect of cellulose sulphate and unithiol on metastatic process. It is believed that the action of parmidin is of an indirect character and is mainly associated with the elimination of the kinin component of microcirculatory disorders in the lungs.
D000818:Animals; D002219:Carbamates / Q000627:therapeutic use*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004112:Dimercaprol / Q000031:analogs & derivatives*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007705:Kinins / Q000037:antagonists & inhibitors / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D011727:Pyridinolcarbamate / Q000627:therapeutic use*; D013997:Time Factors; D014494:Unithiol / Q000627:therapeutic use*
D002219:Carbamates; D007705:Kinins; D004112:Dimercaprol; D014494:Unithiol; D011727:Pyridinolcarbamate; D002482:Cellulose; C020254:cellulose sulfate
Rost i metastazirovanie kartsinomy legkikh L'iuis u mysheĭ pri farmakologicheskikh vozdeĭstviiakh na metabolizm i éffekty kininov.