title: Animal models for schizophrenia: the hippocampally lesioned animal.
abstract: Animals with hippocampal lesions are evaluated as models for schizophrenia according to the criteria of McKinney and Bunney (1969). They seem to comply adequately with the following requirements: similarity of inducing conditions; similarity of behavioral states; similarity of underlying neurobiological mechanisms; and reversibility by usual pharmacological treatment. The model seems adequate to reproduce several symptoms of the disorder, offering a good experimental tool for the analysis of its inducing conditions, affected neurobiological mechanisms, and clinical treatment.
mesh_terms: D000818:Animals; D001288:Attention / Q000502:physiology; D004195:Disease Models, Animal; D018492:Dopamine Antagonists; D005712:Galvanic Skin Response; D006220:Haloperidol / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D007858:Learning / Q000502:physiology; D008568:Memory / Q000502:physiology; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D013028:Space Perception / Q000502:physiology; D013239:Stereotyped Behavior / Q000502:physiology
chemical_list: D018492:Dopamine Antagonists; D006220:Haloperidol