title: Intraruminal soluble glass boluses containing melatonin can induce early onset of ovarian activity in ewes.
abstract: Soluble phosphate glass boluses (preparations A, B, and C) have been developed to release melatonin into the reticulo-rumen of ewes at relatively different (fast, medium or slow) rates. A fourth type (preparation D) containing no melatonin was used as a sham control. Four groups of seasonally anoestrous Suffolk-cross ewes were respectively dosed with preparations A, B, C or D on 4 July. Plasma samples were collected twice weekly for melatonin and progesterone assay. In Groups A, B and C, elevated daytime plasma concentrations of melatonin could be detected for about 5 weeks after bolus administration. However, the pattern of hormone release was variable between groups, with Group C animals maintaining higher plasma melatonin concentrations for a longer period. The control animals had undetectable daytime melatonin levels. The onset of cyclic ovarian activity in the animals treated with the 'slow' release bolus (Group C) was significantly (P less than 0.05) advanced compared to the control group. The 'fast' and 'medium' release treatments (Groups A and B) did not significantly alter the onset of ovarian activity. The results indicate the potential of a novel and convenient method of melatonin delivery for induction of early breeding activity in ewes.
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D005260:Female; D008550:Melatonin / Q000008:administration & dosage* / Q000494:pharmacology; D010053:Ovary / Q000187:drug effects*; D012417:Rumen; D012756:Sheep / Q000502:physiology*
chemical_list: D003692:Delayed-Action Preparations; D008550:Melatonin