Partition coefficients for sevoflurane in human blood, saline, and olive oil.
The purpose of this study was to determine partition coefficients for a new, rapid-acting inhaled anesthetic, sevoflurane. Blood samples were taken from 19 ASA physical status I-III patients ranging in age from 21 to 77 yr who were scheduled for elective surgery. At 37 degrees C, we found a blood/gas partition coefficient of 0.686 +/- 0.047 (mean +/- SD), a saline/gas partition coefficient of 0.370 +/- 0.016; and an oil/gas partition coefficient of 47.2 +/- 2.7. These values are consistent with the clinical observation that sevoflurane is a potent inhaled anesthetic that produces a rapid induction of and recovery from anesthesia.
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood; D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000097:blood*; D002849:Chromatography, Gas / Q000379:methods; D004987:Ethers / Q000097:blood*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008738:Methyl Ethers; D008875:Middle Aged; D000069463:Olive Oil; D010938:Plant Oils; D012044:Regression Analysis; D000077149:Sevoflurane; D012965:Sodium Chloride; D012995:Solubility
D000777:Anesthetics; D004987:Ethers; D006454:Hemoglobins; D008738:Methyl Ethers; D000069463:Olive Oil; D010938:Plant Oils; D000077149:Sevoflurane; D012965:Sodium Chloride