[Studies on the drug permeability of vesical walls. The permeability of mecillinam from the bladder].
When a drug is instilled into the bladder provided with experimental cystitis, the drug could be transferred into the serum. We studied the transfer of mecillinam into the serum, and found that the extent of transfer varied with the method to cause experimental cystitis and also occurred even in the normal bladder. It was suspected that in the inflamed bladder, a part of mecillinam excreted into the urine would possibly be transferred again into the serum through bladder wall.
D000560:Amdinocillin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D000818:Animals; D002463:Cell Membrane Permeability; D003556:Cystitis / Q000378:metabolism; D007322:Instillation, Drug; D008297:Male; D011817:Rabbits; D001743:Urinary Bladder / Q000378:metabolism*
D000560:Amdinocillin