[Ascorbigen and its derivatives--depot preparations of ascorbic acid].
New derivatives of 2-C-/(indolyl-3)methyl/-beta-L-threo-L-glycero-3-hexulofuranosono- 1,4-lactone, vis. 1'-ethylascorbigen, 1'-benzylascorbigen and 1',2'-dimethyl-5'-methoxyascorbigen were obtained. In aquous solutions at physiological temperature and pH values ascorbigens disintegrate rather rapidly to yield L-ascorbic acid, the rate of the latter's formation depending on the substituent in the indole nucleus and increasing with growth of pH and temperature. Intraperitoneal injection of 1'-methylascorbigen to mice leads to steady rise of L-ascorbic acid level in blood plasma.
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000097:blood / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003692:Delayed-Action Preparations; D007211:Indoles / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D051379:Mice
D003692:Delayed-Action Preparations; D007211:Indoles; C053152:ascorbigen; D001205:Ascorbic Acid
Askorbigen i ego proizvodnye--depo-formy askorbinoboĭ kisloty.