Reactions of theophylline, theobromine and caffeine with Fenton's reagent--simulation of hepatic metabolism.
Theophylline and caffeine undergo N-demethylation and hydroxylation by Fenton's reagent to give uric acid derivatives; theophylline is oxidized mainly to 1-methyluric acid, and 1,3-dimethyluric acid and 1-methyluric acid are the major products obtained from caffeine. Theobromine undergoes predominantly N-demethylation to give 7-methylxanthine. The nature of the products indicate that these reactions simulate hepatic drug metabolism.
D002110:Caffeine / Q000378:metabolism*; D006861:Hydrogen Peroxide; D006900:Hydroxylation; D007501:Iron; D008099:Liver / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013805:Theobromine / Q000378:metabolism*; D013806:Theophylline / Q000378:metabolism*
C045076:Fenton's reagent; D002110:Caffeine; D006861:Hydrogen Peroxide; D013806:Theophylline; D007501:Iron; D013805:Theobromine