title: Distribution of 46Sc and 51Cr in tumor-bearing animals and the mechanism for accumulation in tumor and liver.
abstract: Tumor uptake rates, concentrations in mitochondrial fraction (containing lysosome) of liver and tumors, avid accumulations in connective tissue (especially inflammatory tissue) and binding substances in these tissues for 46Sc3+ and 51Cr3+ were essentially similar to those for 67Ga3+, 111In3+, 169Yb3+, 167Tm3+, 95Zr4+ and 181Hf4+. However, the main binding substance of 46Sc3+ and 51Cr3+ in tumor and liver was the acid mucopolysaccharide (as described concerning 95Zr and 181Hf) whose molecular weight exceeded 40,000, although the main binding substance of 67Ga3+, 111In3+, 169Yb3+ and 167Tm3+ was the acid mucopolysaccharide with a molecular weight of about 10,000.
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000000981:diagnostic imaging* / Q000378:metabolism; D002860:Chromium Radioisotopes / Q000378:metabolism*; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011868:Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D012517:Sarcoma, Yoshida / Q000000981:diagnostic imaging* / Q000378:metabolism; D012538:Scandium / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D002860:Chromium Radioisotopes; D011868:Radioisotopes; D012538:Scandium