Porphyrins and pentachlorophenol in rat-liver mitochondria in hexachlorobenzene-induced porphyria.
This study investigated the extent of impairment in functional parameters of liver mitochondria from rats treated for 60 days with hexachlorobenzene (HCB). A constant amount of mitochondrial uncoupling was found throughout the treatment period. At the same time a nearly constant amount of pentachlorophenol was detected in these mitochondria. In contrast, the level of mitochondrial porphyrins increased progressively. There was good correlation between the concentration of mitochondrial pentachlorophenol and the degree of uncoupling of oxidative phosphorylation.
D000818:Animals; D002722:Chlorobenzenes / Q000633:toxicity*; D002733:Chlorophenols / Q000032:analysis*; D005260:Female; D006581:Hexachlorobenzene / Q000633:toxicity*; D008930:Mitochondria, Liver / Q000032:analysis / Q000187:drug effects*; D010416:Pentachlorophenol / Q000032:analysis*; D011164:Porphyrias / Q000139:chemically induced / Q000378:metabolism*; D011166:Porphyrins / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D002722:Chlorobenzenes; D002733:Chlorophenols; D011166:Porphyrins; D006581:Hexachlorobenzene; D010416:Pentachlorophenol