title: Microinjection of kainic acid into the rostral ventrolateral medulla causes hypertension and release of neuropeptide Y-like immunoreactivity from rabbit spinal cord.
abstract: Microinjections of kainic acid were made into the pressor area of the rostral ventrolateral medulla oblongata of anaesthetized rabbits, in the region of the C1 adrenaline-containing neurons. Over the 65 min following the microinjection, there was a significant increase in blood pressure, as well as an increase in the release of neuropeptide Y-like immunoreactivity into the spinal subarachnoid space. These data provide evidence for a functional bulbospinal neuropeptide Y-containing projection which may be responsible for mediating the pressor effects of stimulation of the rostral ventrolateral medulla.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D007608:Kainic Acid / Q000008:administration & dosage*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects* / Q000502:physiology; D008845:Microinjections; D009478:Neuropeptide Y / Q000134:cerebrospinal fluid / Q000378:metabolism*; D011817:Rabbits; D013116:Spinal Cord / Q000378:metabolism*
chemical_list: D009478:Neuropeptide Y; D007608:Kainic Acid