title: Lack of inhibitory effect of metronidazole on theophylline disposition in healthy subjects.
abstract: The effect of metronidazole, at a dose of 1.2 g daily, on theophylline disposition was studied in 10 healthy adult volunteers. Neither theophylline half-life, volume of distribution nor total body clearance was altered by the anti-microbial. It is concluded that metronidazole does not impair theophylline metabolism despite the fact that it is a substituted imidazole.
mesh_terms: D000328:Adult; D004347:Drug Interactions; D006801:Humans; D007700:Kinetics; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D013806:Theophylline / Q000097:blood / Q000378:metabolism*
chemical_list: D008795:Metronidazole; D013806:Theophylline