Role of vitamin A in prevention and treatment of sarcoma 180 in mice.
The effect of deficiency of vitamin A and its supplementation on growth of murine sarcoma 180 was evaluated. The efficacy of cyclophosphamide under depleted and supplemented condition of the vitamin was also scrutinized. Supplemental vitamin A helped to check progression of tumour growth and also increased the effectiveness of chemotherapy. The action is possibly mediated through the host immune system.
D000818:Animals; D001201:Ascites / Q000188:drug therapy; D001835:Body Weight / Q000187:drug effects; D003520:Cyclophosphamide / Q000627:therapeutic use; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy*; D014801:Vitamin A / Q000378:metabolism / Q000627:therapeutic use*; D014802:Vitamin A Deficiency / Q000503:physiopathology
D014801:Vitamin A; D003520:Cyclophosphamide