Comparison of the anti-inflammatory activity of sodium acexamate and zinc acexamate in healing skin wounds in rabbits.
After obtaining an abscess on the inner thigh of rabbits, the resulting inflammatory area was treated with sodium acexamate and zinc acexamate (0.5 ml s.c. of a 7% w/v solution). All animals received labeled leukocytes (111In, 1 mCi, i.v.). The hyperfixation was measured by comparing the inflammatory areas. In the group treated with zinc acexamate, the regression of inflammation was highly significant (p less than 0.001) in comparison with the other groups. These results emphasize the importance of combining zinc with acexamic acid for healing skin wounds.
D000614:Aminocaproates / Q000494:pharmacology*; D015119:Aminocaproic Acid / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
D000614:Aminocaproates; D000893:Anti-Inflammatory Agents; C018802:6-acetylaminocaproic acid; D015119:Aminocaproic Acid