[Phase-specific protein synthesis in human fibroblasts after synchronization by a double thymidine block].
Kinetics of acid-insoluble non-histone protein synthesis during S and G2 cell cycle phases of diploid human fibroblasts and heteroploid transformed cells was investigated. Two distinct groups of protein with different kinetic pattern depending on the cell culture type were revealed. Export of one group of protein and turnover of the other group of acid-insoluble non-histone protein is arrested in heteroploid transformed cells.
D002453:Cell Cycle / Q000187:drug effects*; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D002868:Chromosomal Proteins, Non-Histone / Q000096:biosynthesis*; D004247:DNA / Q000096:biosynthesis; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D011003:Ploidies; D013936:Thymidine / Q000494:pharmacology
D002868:Chromosomal Proteins, Non-Histone; D004247:DNA; D013936:Thymidine
Fazospetsificheskiĭ sintez belkov v fibroblastakh cheloveka posle sinkhronizatsii dvoĭnym timidinovym blokom.