Early intimal lesions in the common carotid artery.
Histological sections of the common carotid arteries from 259 children who were stillborn or died under 16 years of age were examined for intimal thickening, lamellar irregularities and ruptures, foam cells, and fat. Lesions were present at birth in approximately half the children examined, and the incidence increased rapidly in the first two months after birth. All the children had the early features of the prodroma of atheroma by 8 months of age. Compared with the findings of previous studies of the coronary arteries and aorta the histological findings appeared in the carotid arteries at an earlier age. The prevalence of intimal lesions in infant cot deaths, chronic diseases, and congenital heart disease was compared with that in all other children in the study. There was no difference in the cot death group, but in children under 2 years in both the chronic disease and heart deformity group there was a lower incidence of intimal thickening and visible fat.
D000208:Acute Disease / Q000473:pathology; D000293:Adolescent; D001161:Arteriosclerosis / Q000473:pathology; D002339:Carotid Arteries / Q000196:embryology / Q000473:pathology*; D002340:Carotid Artery Diseases / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease / Q000473:pathology; D005260:Female; D005313:Fetal Death / Q000473:pathology*; D006330:Heart Defects, Congenital / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D013398:Sudden Infant Death / Q000473:pathology