Tetrasomy of chromosome 8: an interesting and rare cytogenetic phenomenon in acute nonlymphocytic leukemia.
Trisomy of chromosome #8 is a change commonly associated with acute nonlymphocytic leukemia (ANLL). However, tetrasomy of chromosome #8 in ANLL as a single chromosome change without accompanying abnormalities is extremely rare and, to the best of our knowledge, has not been reported to date. We present here a case of acute monocytic leukemia (AMoL, FAB M5b) with four copies of chromosome #8.
D000208:Acute Disease; D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008297:Male