[Effect of opioid receptor ligands on cell division processes in the corneal epithelium of the white rat].
The effects of the application of synthetic leu-enkephalin analogue--dalargin and naloxone on DNA synthesis and cell division in corneal epithelium were studied with the drugs injected once or five times. The influence of one and five intraperitoneal injections of the drugs in question at a dose of 10 micrograms/kg body weight was also investigated. In both cases the opioid receptor ligands examined activated DNA synthesis with the following adequate increase in mitotic index.
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D003315:Cornea / Q000187:drug effects*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D004848:Epithelium / Q000187:drug effects; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats
D009270:Naloxone; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie ligandov opioidnykh retseptorov na protsessy kletochnogo deleniia épiteliia rogovitsy belykh krys.