A role for corticosterone in the in vivo regulation of the extraneuronal uptake of [3H]-isoprenaline into rat atria.
The role of corticosterone, a potent in vitro inhibitor of extraneuronal uptake, in the regulation of the extraneuronal accumulation of [3H]-isoprenaline into rat atria was examined. Procedures which increased plasma corticosterone levels resulted in a decrease in the corticosterone-sensitive component of extraneuronal accumulation of [3H]-isoprenaline (64% after reserpine treatment and 25% after chronic cold exposure). Procedures which decreased levels of plasma corticosterone resulted in an increase in the corticosterone-sensitive component of extraneuronal accumulation of [3H]-isoprenaline (approximately 20% after adrenalectomy and 32% after hypophysectomy). This increase was partially prevented by the in vivo administration of dexamethasone (40 micrograms kg-1). There was a strong inverse correlation between the plasma corticosterone concentration and the level of extraneuronal uptake into atria (P less than 0.01). Corticosterone appears to play a major role in the regulation of extraneuronal uptake into tissues of the rat.
D000315:Adrenalectomy; D000818:Animals; D003080:Cold Temperature; D003345:Corticosterone / Q000097:blood / Q000502:physiology*; D003907:Dexamethasone / Q000494:pharmacology; D006325:Heart Atria / Q000378:metabolism*; D007016:Hypophysectomy; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology
D003907:Dexamethasone; D012110:Reserpine; D007545:Isoproterenol; D003345:Corticosterone