[Effect of surgical exclusion of the terminal segment of the jejunum on plasma lipid level in rabbits after administration of a cholesterol-fat diet].
The examinations have been performed on 10 native albino rabbits in two experimental groups. Before the experiment the content of a total, free and esterified cholesterol, triglycerides, free fatty acids lipoproteids was determined in heparinised blood plasma. The obtained values served as a control. One group of animals was fed for 21 days a standard food enriched with 4.0 g of cholesterol/day and 4.0 g of lard/day, in the second group of animals a surgical disengagement of a 1/3 distal portion of ileum acc. to the method of Buchwald was performed. After 8 days convalescence the animals were fed for 21 days the same diet as group one. After feeding of atherogenic diet the content of lipid constituents analogical to those in control examinations was determined in blood plasma, and the results were analyzed statistically. It was found that: three weeks overburdening of normal rabbits with cholesterol-fat diet causes a remarkable hiperlipidaemia and an increase of the numerical value of LDL:HDL; operative disengagement of a 1/3 distal portion of ileum before overburdening alimentation enables to maintain normolipidaemia and the numerical value of LDL:HDL ratio on the level approximate to that in controls.
D000818:Animals; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D006949:Hyperlipidemias / Q000209:etiology / Q000517:prevention & control; D007583:Jejunum / Q000601:surgery*; D008055:Lipids / Q000097:blood*; D008297:Male; D011817:Rabbits
D002791:Cholesterol, Dietary; D004041:Dietary Fats; D008055:Lipids
Wpływ operacyjnego wyłaczenia końcowego odcinka jelita kretego na stezenie lipidów osocza krwi po zastosowaniu die ty cholesterolowo-tłuszczowej u królików.