[Systemic, cellular and molecular adjustments induced by administration of peptides having different opioid activities].
Comparative study of effects of the peptides with different opiate activity on metabolism and neurophysiological processes in brain structures (cortical-subcortical, brainstem) revealed resemblance and specifics of delta-sleep inducing peptide (DSIP) and tetrapeptideamide (TPA) effects on subcellular (metabolism of neurotransmitters), cellular (bioelectrical activity) and systemic (behaviour) levels. Both peptides activated serotoninergic system and suppressed responses of brain structures to visual and acoustic stimuli. These peptides also reconstructed multi-sensory peculiarities of brain structures, changing the sensory supply of adaptive behaviour. As opposed to the DSIP, systemic effect of TPA included motor function and resulted in changes of cholinergic system activity levels. DSIP can be useful in studies of informational neuroses in clinics.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002682:Chinchilla; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D004285:Dogs; D004569:Electroencephalography; D005071:Evoked Potentials; D005260:Female; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D009842:Oligopeptides / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism
D007527:Isoenzymes; D009842:Oligopeptides; D012701:Serotonin; C037379:tyrosyl alanyl-glycyl-phenylalaninamide; D003701:Delta Sleep-Inducing Peptide; D008995:Monoamine Oxidase; D000110:Acetylcholinesterase
Sistemnye, kletochnye i molekuliarnye perestroĭki, obuslovlennye vozdeĭstviem peptidov s razlichnoĭ opioidnoĭ aktivnost'iu.