Identification of N-carboxyethyl gamma-aminobutyric acid in bovine brain and human cerebrospinal fluid.
The di-carboxylated derivative of spermidine, N-carboxyethyl gamma-aminobutyric acid (CEGABA) has been identified in bovine brain and human cerebrospinal fluid by HPLC. This discovery strongly suggests the existence of a metabolic pathway connecting polyamines and GABA via putreanine and CEGABA through progressive oxidative deamination of the amino terminal groups in spermidine.
D000818:Animals; D001923:Brain Chemistry; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000134:cerebrospinal fluid
C044767:2-carboxyethyl gamma-aminobutyric acid; D005680:gamma-Aminobutyric Acid