Differences in the inhibitory effect of cimetidine on desipramine metabolism between rapid and slow debrisoquin hydroxylators.
The disposition of a 25 mg single oral dose of desipramine was investigated in five rapid and four slow hydroxylators of debrisoquin before and during oral administration of 1200 mg cimetidine daily. AUC and elimination half-life of desipramine increased during cimetidine administration in rapid but not in slow hydroxylators. This was the result of a decrease in overall clearance. The urinary recovery of 2-hydroxydesipramine was significantly decreased in rapid hydroxylators during cimetidine administration. We conclude that cimetidine inhibits the metabolism of desipramine in rapid but not in slow hydroxylators.
D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D003647:Debrisoquin / Q000378:metabolism; D003891:Desipramine / Q000097:blood / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D006900:Hydroxylation; D007546:Isoquinolines; D007700:Kinetics; D008657:Metabolic Clearance Rate
D007546:Isoquinolines; D002927:Cimetidine; D003891:Desipramine; D003647:Debrisoquin