Effects of anti-GRP gamma-globulin on gastrin release and gastric secretion in the rat: evidence for the physiologic role of endogenous GRP in the regulation of gastric function.
To assess the effects of endogenous GRP on vagal gastrin release and acid secretion, anti-GRP gamma-globulin was infused in anesthetized rats to bind endogenously released GRP. Anti-GRP gamma-globulin blocked the gastrin-releasing effects caused by 4 micrograms/kg/hr of exogenous GRP infusion and suppressed gastrin release by electrical vagal stimulation. In spite of this suppression, anti-GRP gamma-globulin did not alter basal or vagal-stimulated acid secretion.
D000818:Animals; D004558:Electric Stimulation; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D019886:Gastrin-Releasing Peptide; D005755:Gastrins / Q000378:metabolism*; D007106:Immune Sera / Q000494:pharmacology; D008297:Male; D010455:Peptides / Q000276:immunology / Q000494:pharmacology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000502:physiology
D005755:Gastrins; D007106:Immune Sera; D010455:Peptides; D019886:Gastrin-Releasing Peptide