Regulatory effect of pig heart phospholipids on heart muscle AMP-deaminase.
AMP-deaminase purified from pig heart has been found to be activated by liposomes prepared from phospholipids extracted from pig heart mitochondria, microsomes and cytoplasm, as well as by intact microsomes. The activation by phospholipids occurred only in the presence of ATP and after the enzyme had been preincubated with liposomes for 30 min. Liposomes prepared from cardiolipin displayed an inhibitory effect on pig heart AMP-deaminase.
D000659:AMP Deaminase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002308:Cardiolipins / Q000494:pharmacology; D003600:Cytosol / Q000032:analysis; D004789:Enzyme Activation / Q000187:drug effects; D007700:Kinetics; D008081:Liposomes / Q000494:pharmacology; D008563:Membrane Lipids / Q000494:pharmacology; D008861:Microsomes / Q000032:analysis; D008929:Mitochondria, Heart / Q000032:analysis; D009206:Myocardium / Q000032:analysis / Q000201:enzymology*; D009709:Nucleotide Deaminases / Q000378:metabolism*; D010743:Phospholipids / Q000494:pharmacology*; D013552:Swine
D002308:Cardiolipins; D008081:Liposomes; D008563:Membrane Lipids; D010743:Phospholipids; D000255:Adenosine Triphosphate; D009709:Nucleotide Deaminases; D000659:AMP Deaminase