Rimantadine pharmacokinetics after single and multiple doses.
Twenty-four healthy adult male volunteers were randomly assigned to one of two rimantadine regimens. The 12 volunteers assigned to regimen 1 orally received a single 100-mg rimantadine tablet followed 5 days later by 100 mg of rimantadine twice a day for 10 days. Volunteers assigned to regimen 2 ingested a single 100-mg rimantadine tablet followed 5 days later by 100 mg once a day for 10 days. The results of the study suggest that the pharmacokinetics of rimantadine are linear and accumulation of the drug during repetitive multiple doses is predictable.
D000218:Adamantane / Q000031:analogs & derivatives*; D000293:Adolescent; D000328:Adult; D004334:Drug Administration Schedule; D006801:Humans; D007700:Kinetics; D008297:Male; D011897:Random Allocation; D012299:Rimantadine / Q000008:administration & dosage / Q000378:metabolism*
D012299:Rimantadine; D000218:Adamantane