Lack of effect of warfarin on L-thyroxine metabolism.
The effect of a single 50 mg dose of warfarin sodium on thyroxine monodeiodination was examined in eight healthy human subjects. There was no evidence that warfarin inhibits 5'-monodeiodination, although such inhibition exists in rats.
D000328:Adult; D005260:Female; D006801:Humans; D007453:Iodide Peroxidase / Q000037:antagonists & inhibitors; D008297:Male; D013963:Thyroid Hormones / Q000097:blood; D013974:Thyroxine / Q000378:metabolism*; D014859:Warfarin / Q000494:pharmacology*
D013963:Thyroid Hormones; D014859:Warfarin; D007453:Iodide Peroxidase; D013974:Thyroxine