[Hepatotropic action of benzobamil in CCl4 poisoning].
The administration of an antiepileptic drug--benzobamilum-to rats with CCl4-induced hepatitis prevents the development of liver parenchyma necrosis, promotes the retention of normal enzyme activity in hepatocytes, stimulates the excretory and antitoxic liver functions. The drug has antioxidant properties, inhibits the production of lysophosphatidylcholine and the reduction in phosphatidylcholine content in the liver homogenates but fails to intensify CCl4-induced steatosis.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D010424:Pentobarbital / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051381:Rats
C055631:benzobamil; D010424:Pentobarbital
Gepatotropnoe deĭstvie benzobamila pri intoksikatsii CCl4.