Effect of macrophage stimulation on parasympathetic airway contraction in dogs.
The effect of lung macrophages stimulated with calcium ionophore on parasympathetic contractile response of canine bronchial rings was studied. Macrophages augmented the contraction induced by electrical field stimulation, an effect that was inhibited by indomethacin and by SQ29548, a thromboxane A2 receptor antagonist, but had no effect on the contractile response to exogenous acetylcholine. These results suggest that macrophage-derived thromboxane A2 facilitates cholinergic neurotransmission prejunctionally in airway smooth muscle.
D000818:Animals; D001249:Asthma / Q000209:etiology; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001980:Bronchi / Q000502:physiology*; D004285:Dogs; D004558:Electric Stimulation; D005231:Fatty Acids, Unsaturated; D006834:Hydrazines / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000502:physiology*; D009119:Muscle Contraction; D010275:Parasympathetic Nervous System / Q000502:physiology*; D013928:Thromboxane A2 / Q000502:physiology
D019086:Bridged Bicyclo Compounds, Heterocyclic; D005231:Fatty Acids, Unsaturated; D006834:Hydrazines; D013928:Thromboxane A2; C045749:SQ 29548; D007213:Indomethacin