Tissue metal shifts by a single exposure to metals in rats.
Intraperitoneal pretreatment with a large dose of Cd, Zn, Hg, Mn or Ag remarkably depressed the lethal effects of X-ray. The CHX pretreatment before metal challenge depressed the lethal effects of X-ray more remarkably. Therefore, metal-binding protein may not play an important role in protective effects of metal pretreatment on the lethal effects of X-ray, but quantum mechanical characters of metals may do so.
D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D002352:Carrier Proteins / Q000502:physiology; D003300:Copper / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D007854:Lead / Q000494:pharmacology; D008297:Male; D008628:Mercury / Q000494:pharmacology; D008670:Metals / Q000378:metabolism*; D011835:Radiation Protection; D051381:Rats; D011919:Rats, Inbred Strains; D012834:Silver / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology
D002352:Carrier Proteins; D008670:Metals; D002104:Cadmium; D007854:Lead; D012834:Silver; D003300:Copper; D003907:Dexamethasone; D003513:Cycloheximide; D008628:Mercury; D015032:Zinc