An increase in glial fibrillary acidic protein follows brain hyperthermia in rats.
Previously, we have demonstrated that an increase in the astrocyte-associated protein, glial fibrillary acidic protein (GFAP), accompanies brain injury induced by a variety of chemical insults. In the present study we examined the effects of microwave-induced hyperthermia of the CNS on the concentration of GFAP in several brain regions of the Long-Evans rat. Irradiation resulted in a time-related increase in GFAP in olfactory bulbs and cortex, areas of maximum heating. The increase in GFAP following a brain temperature increase suggests that heating of brain tissue may be sufficient to provoke an injury response comparable to that induced by chemical and physical insult.
D000818:Animals; D001923:Brain Chemistry; D002531:Cerebellum / Q000032:analysis; D003342:Corpus Striatum / Q000032:analysis; D005260:Female; D005625:Frontal Lobe / Q000032:analysis; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis*; D006979:Hyperthermia, Induced; D008872:Microwaves / Q000009:adverse effects; D009830:Olfactory Bulb / Q000032:analysis; D051381:Rats
D005904:Glial Fibrillary Acidic Protein