title: Response of the growth plates to tibial osteotomy in rats.
abstract: The parameters of cellular proliferation and growth in the growth plates of immature rats were measured after unilateral tibial osteotomy and used to calculate growth rates. Distal osteotomy of one tibia was followed by a bilateral increase in the calculated growth rate of the distal growth plates. However, the ipsilateral distal growth plate grew faster than the contralateral between 12 and 18 days after operation, which appeared to be related to increased cell proliferation and height. Proximal osteotomy led to an increase in growth rates proximally which was more marked on the contralateral side. The lesser response of the ipsilateral growth plate may have been due to local impairment of blood supply, or to greater local release of metabolites after bony damage. Distal tibial osteotomy gave similar results to circumferential release of the distal tibial periosteum. Proximal osteotomy, however, produced a relative impairment of growth on the operated side. This may be of importance in the correction of childhood deformities associated with inequality of leg length.
mesh_terms: D000818:Animals; D002455:Cell Division; D006132:Growth Plate / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D008297:Male; D010027:Osteotomy / Q000379:methods*; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D013977:Tibia / Q000601:surgery*; D014316:Tritium
chemical_list: D014316:Tritium; D013936:Thymidine