title: The ergometrine test: effects on esophageal motility in patients with chest pain and normal coronary arteries.
abstract: Ergometrine can evoke coronary spasm in patients with variant angina. The cause of ergometrine-induced chest pain in the absence of coronary spasm is not clear. To determine whether ergometrine produced esophageal dysfunction and chest pain, we evaluated 28 patients by esophageal manometry. Six had chest pain in response to ergometrine during cardiac catheterization (group I) and 22 did not (group II). Results of cardiac catheterization were normal in all patients. Seven volunteers with no history of chest pain formed a control group (group III). Esophageal manometry was performed before and after ergometrine administration (0.4 mg I.V.). Ergometrine provocation during esophageal manometry caused significant deterioration in esophageal motility associated with familiar pain in 5/6 group 1 patients. The motility disorders were characterized by repetitive contracts of high amplitude and long duration in the distal esophagus. No patient from group II or III experienced chest pain after ergometrine and only 2 from group II developed long duration contractions. Thus, we conclude that in patients with normal coronary angiograms, ergometrine-induced chest pain without associated coronary spasm suggests that esophageal motility disorders originate chest pain.
mesh_terms: D000787:Angina Pectoris / Q000175:diagnosis; D002637:Chest Pain / Q000139:chemically induced* / Q000175:diagnosis; D003937:Diagnosis, Differential; D004874:Ergonovine / Q000009:adverse effects*; D004947:Esophagus / Q000187:drug effects / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008365:Manometry; D010528:Peristalsis / Q000187:drug effects*
chemical_list: D004874:Ergonovine