[Contemporaneous presentation of plasma cell leukemia and multiple myeloma. Description of a clinical case with a biclonal component].
A case of simultaneous evidence of plasma cell leukaemia and multiple myeloma is reported. Plasma cell leukaemia doesn't represent an evolution of multiple myeloma, but a primitive disease, because the two forms of plasma cell dyscrasia arose from two different neoplastic plasma cell populations. In fact, leukaemic plasma cell produced IgA and were PAS-positive, while myelomatous plasma cells produced IgG and were PAS-negative. From this case, some hypothesis on simultaneous development of the two types of plasma cell neoplasias are discussed.
D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007952:Leukemia, Plasma Cell / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000276:immunology / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology
D007070:Immunoglobulin A; D007074:Immunoglobulin G
Contemporanea presentazione di leucemia plasmacellulare e mieloma multiplo. Descrizione di un caso clinico con componente biclonale.