Barbiturate narcosis and estrogen levels in women.
Pregnant women with high estrogen levels were more sensitive to barbiturate-induced narcosis and hypothermia than nonpregnant and postmenopausal women. Within each group, there was a negative correlation between estrogen level and decreased sensitivity to barbiturates. It appears that estrogen alters resistance to barbiturates through its effect on the activity of dopamine receptors.
D000328:Adult; D000771:Anesthesia, Intravenous; D002490:Central Nervous System / Q000187:drug effects*; D004107:Dilatation and Curettage; D004967:Estrogens / Q000097:blood*; D005260:Female; D006801:Humans; D008593:Menopause; D008723:Methohexital / Q000494:pharmacology*; D008875:Middle Aged; D011247:Pregnancy; D011374:Progesterone / Q000097:blood
D004967:Estrogens; D011374:Progesterone; D008723:Methohexital