The short and long term effect of gastric partitioning surgery on serum protein levels.
The morbidly obese who undergo elective gastric partitioning surgery serve as models of surgical stress and subsequent severe protein calorie restriction. The short and long term effects of gastric partitioning surgery on circulating proteins and the specific micronutrients carried by the proteins were studied in 22 such patients (ages 23-56 years). Serum micronutrient values paralleled the levels of their carrier proteins. Mean concentrations of both short and long turnover proteins decreased significantly in the early postoperative period, whereas the acute phase reactant ceruloplasmin reached preoperative levels by the seventh postoperative day. Transthyretin and retinol binding protein remained depressed with long term reductions in protein and calorie intake, whereas ceruloplasmin and transferrin were somewhat less sensitive to prolonged protein-calorie restriction. Mean serum albumin, after an initial postoperative fall, rose to the baseline level by 1 month after surgery. Serum albumin levels remained within the normal range despite low protein and calorie intakes.
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000097:blood; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000628:therapy*; D011228:Prealbumin / Q000097:blood; D012177:Retinol-Binding Proteins / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D013270:Stomach / Q000601:surgery*; D013312:Stress, Physiological / Q000097:blood; D014168:Transferrin / Q000378:metabolism; D014801:Vitamin A / Q000097:blood
D001798:Blood Proteins; D004044:Dietary Proteins; D011228:Prealbumin; D012177:Retinol-Binding Proteins; D012709:Serum Albumin; D014168:Transferrin; D014801:Vitamin A; D003300:Copper; D007501:Iron; D002570:Ceruloplasmin