title: Familial glioma: occurrence within the "familial cancer syndrome" and systemic malformations.
abstract: The family pedigree across eight generations is presented with an association of osteochondrodysplasia, other skeletal abnormalities, familial glial tumours in a father and his son, colonic and other adenomatous disease, and pigment changes. This family cluster of diseases is considered to be a dysontogenetic process with blastomatous features and grouped within the phakomastoses. A review of the literature indicates that some "familial gliomas" show additional malformations, thus resembling phakomatoses. Others are found to be members within a "familial cancer syndrome". A trait of "hereditary glioma" apart from these syndromes is difficult to identify, especially if only sibships are considered which are likely to share common environmental factors.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000002:abnormalities; D001932:Brain Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000150:complications / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009386:Neoplastic Syndromes, Hereditary / Q000473:pathology; D010009:Osteochondrodysplasias / Q000150:complications / Q000235:genetics*; D010375:Pedigree