Effects of adrenoceptor agonists and antagonists on sulfobromophthalein disposition in mice.
The effects of alpha 2-adrenoceptor agonists on sulfobromophthalein (BSP) disposition in mice were studied. It was found that agents with both central and peripheral activities (clonidine, guanabenz, B-HT 920 and methyldopa) as well as peripherally acting alpha 2-adrenoceptor agonists (para amino-clonidine and St 91) inhibited sulfobromophthalein disposition in the mouse, and also caused substantial hypothermia. The effects of these agonists were inhibited by yohimbine, a specific alpha 2-antagonist, except for those of para amino-clonidine where only partial reversal was achieved. The effects of clonidine on BSP disposition were also reversed by piperoxan but not by the alpha 1-adrenoceptor antagonists, prazosin and phenoxybenzamine, nor by the beta-blocker, propranolol. These results suggest that, in mice, peripheral alpha 2-adrenoceptors are involved in the effects of the alpha-agonists on BSP disposition.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D003864:Depression, Chemical; D004347:Drug Interactions; D008297:Male; D051379:Mice; D013448:Sulfobromophthalein / Q000378:metabolism*; D013565:Sympatholytics / Q000494:pharmacology*; D013566:Sympathomimetics / Q000494:pharmacology*
D013565:Sympatholytics; D013566:Sympathomimetics; D013448:Sulfobromophthalein