Concentrations of calmodulin in sperm in relation to their motility in fertile euspermic and infertile asthenozoospermic men.
The relationship between calmodulin and sperm motility was assessed in euspermic and asthenozoospermic men using radioimmunoassay and time-lapse photography, respectively. There was a significant decrease in the % sperm motility, mean sperm velocity, motility index and % of progressively motile sperm in the asthenozoospermic group when compared with euspermic men. The former also exhibited a higher % of sperm with erratic or circular motility. Calmodulin concentration in sperm from the asthenozoospermic men was 4.8 +/- 1.4 micrograms/mg protein compared with 12.6 +/- 2.3 in euspermic men (P less than 0.0005). The differences observed in sperm motility characteristics between the two groups may, thus, be due to the observed differences in the concentration of calmodulin.
D000328:Adult; D002147:Calmodulin / Q000032:analysis*; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000378:metabolism*; D011863:Radioimmunoassay; D013081:Sperm Motility; D013094:Spermatozoa / Q000032:analysis*
D002147:Calmodulin