Antibodies against the insulin receptor in paraneoplastic acanthosis nigricans.
Acanthosis nigricans is a skin disorder associated with endocrine abnormalities, autoimmune disease, and systemic malignancies. Insulin resistance is a common accompaniment of the nonmalignant varieties of acanthosis nigricans. A 44-year-old man is described with a functioning metastatic pheochromocytoma, acanthosis nigricans, and insulin-resistant diabetes mellitus. Studies of insulin action showed a low titer of anti-insulin antibodies and a very high titer of antibodies against the insulin receptor. This case documents for the first time insulin resistance due to anti-insulin receptor antibodies in a paraneoplastic variety of acanthosis nigricans.
D000052:Acanthosis Nigricans / Q000276:immunology* / Q000473:pathology; D000310:Adrenal Gland Neoplasms / Q000276:immunology*; D000328:Adult; D003920:Diabetes Mellitus / Q000276:immunology; D006801:Humans; D007330:Insulin Antibodies / Q000276:immunology*; D007333:Insulin Resistance; D008297:Male; D010257:Paraneoplastic Syndromes / Q000276:immunology*; D010673:Pheochromocytoma / Q000276:immunology*; D011972:Receptor, Insulin / Q000276:immunology*; D012867:Skin / Q000473:pathology
D007330:Insulin Antibodies; D011972:Receptor, Insulin