Intratympanic injection of sodium arsanilate (atoxyl) solution results in postural changes consistent with changes described for labyrinthectomized rats.
Intratympanic injections of sodium arsanilate (atoxyl) have been shown to produce vestibular dysfunction in the rat. Unilateral and bilateral dysfunction can be distinguished by changes in the animals' postures. These changes are consistent with changes described for unilateral or bilateral labyrinthectomized rats. The intratympanic injection technique offers a simple yet effective alternative to labyrinthectomy.
D000818:Animals; D001147:Arsanilic Acid / Q000008:administration & dosage*; D001152:Arsenicals / Q000008:administration & dosage*; D007758:Ear, Inner / Q000187:drug effects*; D004432:Ear, Middle / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects*; D011187:Posture; D051381:Rats
D001152:Arsenicals; D001147:Arsanilic Acid