title: Oxygen free radicals and duodenal ulcer pain. Preliminary data.
abstract: Starting from the hypothesis that duodenal ulcer pain is induced by oxygen free radicals, a process demonstrated in other types of bacterial or nonbacterial inflammations, we used a powerful scavenger of human origin in local periulcerous injections performed through endoscope in 12 patients with duodenal ulcer and active lasting pain. Pain subsided in all patients for a variable period of time. The results obtained plead for the involvement of oxygen free radicals in the mechanism of ulcer pain.
mesh_terms: D000328:Adult; D002374:Catalase / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D005609:Free Radicals; D006801:Humans; D008297:Male; D010146:Pain / Q000209:etiology; D013482:Superoxide Dismutase / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D005609:Free Radicals; D002374:Catalase; D013482:Superoxide Dismutase; C050165:epurox