Isolation and structure of an epidermal mitosis inhibiting pentapeptide.
A mitosis inhibiting peptide pyroGlu-Glu-Asp-Ser-GlyOH has been isolated from mouse skin extracts. Both the biological and a synthetic peptide with the same structure reversibly inhibit epidermal mitoses in a curvilinear fashion after intraperitoneal injection. The two compounds are chromatographically identical.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D051379:Mice; D008812:Mice, Hairless; D008938:Mitosis / Q000187:drug effects; D009842:Oligopeptides / Q000302:isolation & purification* / Q000494:pharmacology; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D012867:Skin / Q000032:analysis* / Q000166:cytology / Q000187:drug effects
D009842:Oligopeptides; C050550:epidermal pentapeptide; D011761:Pyrrolidonecarboxylic Acid