[Duration of the antihypothermic action of the antidepressant ftoratsizin in galanthamine-induced hypothermia].
The presence of m-anticholinergic properties in ftoratsizin was confirmed in experiments of rats. Ftoratsizin was found to possess the ability of preventing galanthamine-induced hypothermia. Unlike ftoratsizin, amizil exhibited an incomplete and transient antagonistic effect towards galanthamine (within an hour) not depending on the dose.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D001535:Benactyzine / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005702:Galantamine; D007035:Hypothermia / Q000139:chemically induced / Q000188:drug therapy*; D010640:Phenothiazines / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors
D000929:Antidepressive Agents, Tricyclic; D010640:Phenothiazines; D005702:Galantamine; C001228:fluoracizine; D001535:Benactyzine
O dlitel'nosti antigipotermicheskogo deĭstviia antidepressanta ftoratsizina pri gipotermii, vyzvannoĭ galantaminom.