title: Enhancement of DEN-induced hepatocellular nodule development by Opisthorchis viverrini infection in Syrian golden hamsters.
abstract: The influence of Opisthorchis viverrini liver fluke infection on development of diethylnitrosamine (DEN)-induced hepatocellular nodules was investigated in Syrian golden hamsters. Infection with 60 metacercariae, 4 weeks prior to administration of DEN for 12 weeks in the drinking water at dose levels of 10, 20 and 40 p.p.m., resulted in a significantly increased yield of nodular lesions as compared with the group receiving carcinogen treatment alone. The results indicate an importance for parasite-associated liver injury and compensatory regeneration in hepatocarcinogenesis and suggest a possible role for Opisthorchis infestation in the generation of hepatocellular tumours in man.
mesh_terms: D000818:Animals; D003043:Cocarcinogenesis; D006224:Cricetinae; D004052:Diethylnitrosamine; D008114:Liver Neoplasms, Experimental / Q000209:etiology*; D008647:Mesocricetus; D009889:Opisthorchiasis / Q000150:complications*; D011230:Precancerous Conditions / Q000209:etiology*
chemical_list: D004052:Diethylnitrosamine