Rapid normalization of the dexamethasone suppression test with mianserin.
Dexamethasone suppression tests (DSTs) were carried out in 6 depressed patients and 2 with schizophrenia before and 48 to 72 hours after starting treatment. All 8 were non-suppressors before treatment but the 5 patients treated with mianserin and 1 treated with chlorpromazine had normal suppression with the repeat DST, unrelated to clinical change. Non-suppression persisted in the 2 patients treated with ECT or haloperidol. Mianserin and chlorpromazine could, therefore, be associated with false negative DST results. Possible mechanisms for this are discussed.
D002746:Chlorpromazine / Q000627:therapeutic use; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D003907:Dexamethasone; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008803:Mianserin / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy
D008803:Mianserin; D003907:Dexamethasone; D006220:Haloperidol; D002746:Chlorpromazine; D006854:Hydrocortisone