Selective retrograde labeling with D-[3H]-aspartate in the monkey olivocerebellar projection.
The specificity of D-[3H]-aspartate as a retrograde marker was investigated following large injections of this tritiated amino acid in the monkey cerebellar cortex. Retrogradely labeled neurons were found exclusively in the inferior olive, a fact which is consistent with previous studies in the rat. These results show that D-[3H]-aspartate is a selective tracer that might also be useful to delineate excitatory pathways using glutamate and/or aspartate as neurotransmitter(s) in the monkey brain.
D000818:Animals; D001224:Aspartic Acid; D001345:Autoradiography; D002525:Cerebellar Cortex / Q000033:anatomy & histology*; D005260:Female; D008252:Macaca fascicularis / Q000033:anatomy & histology; D009434:Neural Pathways / Q000033:anatomy & histology; D009847:Olivary Nucleus / Q000033:anatomy & histology*
D001224:Aspartic Acid