Effect of altrenogest and Lutalyse on parturition control, plasma progesterone, unconjugated estrogen and 13,14-dihydro-15-keto-prostaglandin F2 alpha in sows.
To investigate control of parturition time, 154 sows farrowing 220 litters at three locations were treated with altrenogest and Lutalyse (PG). The four treatment groups were: 1) no treatment (control group); 2) an im injection of 15 mg of PG at 1000 on d 111, 112 or 113 of gestation (d 0 = first day of estrus and gestation); 3) altrenogest (20 mg X sow-1 X d-1) fed twice daily for 4 d starting on d 109, 110 or 111; and 4) altrenogest and an injection of PG at 1000 on the day after the last feeding of altrenogest. Control sows at the University of Delaware (UD), University of Maryland (UM) and USDA, Beltsville Agricultural Research Center (BARC) had mean gestation lengths of 113.5, 114.2 and 115.7 d and live pigs/litter were 10.5, 11.0 and 7.4, respectively. Altrenogest started by d 110 prevented unscheduled early farrowing and increased (P less than .01) gestation length by 1.7 and 1.1 d, respectively, at UD and UM, but had not effect at BARC. The time from PG to parturition was 24.3, 22.6 and 34.4 h, respectively, at UD, UM and BARC. More sows at UD and UM farrowed between 0700 and 1700 on the expected day of parturition after injection of PG (59.3%) than with no PG (20.7%; P less than .05). The high incidence of small litters (less than six pigs) from sows inseminated with frozen semen at BARC resulted in negative correlations of live pigs/litter with gestation length (r = -.533, P = .0001) and with time from PG injection to birth of first pig (r = -.425, P = .017); these correlations were not significant at UD and UM where only natural service was used.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D015237:Dinoprost / Q000031:analogs & derivatives*; D004963:Estrenes / Q000494:pharmacology*; D004967:Estrogens / Q000097:blood*; D005260:Female; D007743:Labor, Obstetric / Q000187:drug effects*; D010120:Oxytocics / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011374:Progesterone / Q000097:blood*; D045167:Progesterone Congeners / Q000494:pharmacology*; D011460:Prostaglandins F / Q000097:blood*; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D013552:Swine / Q000502:physiology*; D014204:Trenbolone Acetate / Q000031:analogs & derivatives / Q000494:pharmacology*
D004963:Estrenes; D004967:Estrogens; D010120:Oxytocics; D045167:Progesterone Congeners; D011460:Prostaglandins F; D011461:Prostaglandins F, Synthetic; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; C023445:altrenogest; D011374:Progesterone; D015237:Dinoprost; C010714:dinoprost tromethamine; D014204:Trenbolone Acetate