Myelodysplastic syndrome: identification in the routine hematology laboratory.
The Coulter S+IV electronically generates an automated white blood cell differential which counts 10,000+ cells per sample, separating lymphocytes, mononuclear cells, and granulocytes. In patients with preleukemic or so-called myelodysplastic syndromes, the histograms are consistently abnormal. CBCs of five patients demonstrate the variable features of myelodysplasia involving abnormal monocytosis, neutropenia, thrombocytopenia, and macro-ovalocytic anemias. The histogram analysis of white blood cells is a rapid, economic way of alerting the hematologist to a possible diagnostic problem in the elderly patient population.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001772:Blood Cell Count / Q000295:instrumentation*; D001856:Bone Marrow Examination; D004906:Erythrocyte Count / Q000295:instrumentation; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007958:Leukocyte Count / Q000295:instrumentation; D008297:Male; D009190:Myelodysplastic Syndromes / Q000175:diagnosis*; D010976:Platelet Count / Q000295:instrumentation