NMR tomography for the visualization of the diffusion of Gd-DTPA in agar-gel and in brain tissue--in vitro studies.
Serial magnetic resonance images of a diffusion model and of brain specimens have been performed to study the diffusion behavior of a paramagnetic complex (Gd-DTPA). The model consisted of solidified agar gel with layered Gd-DTPA solution on top of the gel. Corresponding studies have been performed with the brain specimen to visualize the penetration of the marker through the extracellular space into the brain tissue. Diffusion coefficients for the agar gel and the brain tissue model have been calculated. Magnetic resonance tomography proves to be a promising method for the study of complicated diffusion processes of paramagnetic complexes in biological tissue.
D000362:Agar; D000818:Animals; D001921:Brain; D004058:Diffusion; D005110:Extracellular Space; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D004369:Pentetic Acid; D013552:Swine
D004369:Pentetic Acid; D000362:Agar