Influence of hydrocortisone acetate on the magnesium metabolism during pregnancy in rats.
The influence of hydrocortisone acetate i.m. administered (4 mg/100 g of body weight and day) to pregnant rats, on magnesium nutritive utilization and bone magnesium content in the mothers and its possible repercussions on newborn Mg content are studied. Hydrocortisone acetate treatment significantly reduces Mg content in the litters, which can be explained on the basis of a significant decrease in both the magnesium absorption and retention by the hormone-treated mothers. The mobilization of femoral magnesium and the increase in the urinary excretion of the cation provoke a reduction in magnesium retention in the treated mothers.
D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005243:Feces / Q000032:analysis; D005260:Female; D005269:Femur / Q000378:metabolism; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D008274:Magnesium / Q000378:metabolism* / Q000652:urine; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
C021650:hydrocortisone acetate; D008274:Magnesium; D006854:Hydrocortisone