Immunogenicity of acrylate chemicals as assessed by antibody induction.
The immunogenicities of two acrylate chemicals, trimethylolpropane triacrylate (TMPTA) and methyl acrylate (MeAc), and one related vinyl compound, 4-vinyl pyridine (4VP), were investigated by determining the in vivo induction of IgG antibodies in guinea pigs. The injection of the chemicals emulsified in Freund's complete adjuvant resulted in the induction of serum antibody responses against MeAc and 4VP but not TMPTA. However, antibody with anti-TMPTA activity was produced following immunization of guinea pigs with TMPTA conjugated to protein, which allowed comparisons to be made of the immunogenic structural features of the compounds.
D000179:Acrylates / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation; D005260:Female; D006168:Guinea Pigs; D007074:Immunoglobulin G / Q000096:biosynthesis; D008689:Methacrylates / Q000276:immunology*; D011506:Proteins / Q000378:metabolism; D011863:Radioimmunoassay
D000179:Acrylates; D007074:Immunoglobulin G; D008689:Methacrylates; D011506:Proteins; C028643:trimethylolpropane trimethacrylate; C035956:methyl acrylate