title: Effect of albendazole sulphoxide on viability of hydatid protoscoleces in vitro.
abstract: Hydatid protoscoleces obtained from sheep (infected with Echinococcus granulosus) were treated in culture medium with albendazole sulphoxide at final concentrations of 100, 500 and 1000 micrograms/l and the viability was assessed at regular intervals. Over a period of up to 31 days concentrations of 500 and 1000 micrograms/l of sulphoxide significantly reduced the viability in treated groups, as compared with appropriate controls, whilst 100 micrograms/l of sulphoxide had no effect.
mesh_terms: D015766:Albendazole / Q000031:analogs & derivatives*; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004446:Echinococcus / Q000187:drug effects*; D005849:Gerbillinae; D066298:In Vitro Techniques
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D015766:Albendazole; C027186:albendazole sulfoxide