Mechanisms of the angiotensin II effects on the exploratory behavior of rats in open field. I. Interaction of angiotensin II with saralasin and catecholaminergic drugs.
The effects of the octapeptide angiotensin II (AT II) and its possible interaction with catecholaminergic (mainly dopaminergic) neurotransmission on the exploratory behavior of male rats in open field were studied. AT II changed exploratory behavior in a nonlinear dose-effect manner. The stimulant effects of AT II were antagonized by the AT II receptor antagonist saralasin. The AT II effects were increased by the DAergic agonists apomorphine and nomifensine and were decreased by the DAergic antagonist haloperidol and by the inhibitor of catecholamine synthesis alpha-methyl-para-tyrosine. It is suggested that the effects of AT II on open field behavior are realized through specific AT II receptors and through interactions with catecholaminergic (mainly dopaminergic) neurotransmission in the brain.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002395:Catecholamines / Q000502:physiology*; D004347:Drug Interactions; D005106:Exploratory Behavior / Q000187:drug effects*; D006120:Grooming / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009627:Nomifensine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012504:Saralasin / Q000494:pharmacology*; D014363:Tryptamines / Q000494:pharmacology
D002395:Catecholamines; D014363:Tryptamines; D000804:Angiotensin II; D009627:Nomifensine; C015293:indopan; D012504:Saralasin; D006220:Haloperidol; D001058:Apomorphine