Tc-99m labeled triethelene tetraamine polysterene resin gastric emptying studies in bulimia patients.
To evaluate gastric emptying in patients with bulimia, 20 patients (all women, ranging in age from 12 to 49 years) with upper gastrointestinal symptoms ingested 150-200 microCi 99mTc-triethelene tetraamine polysterene resin in cereal and had scintigraphy in the supine position. Data were accumulated at 5 min intervals to determine the gastric emptying time (GET). The results showed that the gastric emptying time was prolonged in 12 patients and decreased in 8. All 12 patients with prolonged emptying time were given 10 mg metoclopramide intravenously; 9 of these had a good response and 3 had no response. Although all patients had subjective symptoms of gastric dysfunction, the results indicate that about 60% had delayed and 40% had rapid gastric emptying. The findings of two extremes of gastric emptying time remain to be explained, however, this enables (a) objective documentation of gastric emptying as this technique (b) can separate those patients with rapid GET from those with prolonged GET, who might benefit from metoclopramide.
D000293:Adolescent; D000328:Adult; D002032:Bulimia / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying; D006801:Humans; D008787:Metoclopramide / Q000627:therapeutic use; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D011137:Polystyrenes; D011877:Radionuclide Imaging; D013270:Stomach / Q000000981:diagnostic imaging; D013667:Technetium; D013997:Time Factors
D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D011137:Polystyrenes; C029413:technetium Tc 99m triethylenetetramine polystyrene; D013667:Technetium; D008787:Metoclopramide