title: Mitochondrial mutagenesis in yeast: mutagenic specificity of EMS and the effects of RAD9 and REV3 gene products.
abstract: EMS is capable of inducing point mutations in mitochondrial genomes of yeast. It induces efficiently the mitochondrial suppressor mutation of the mitochondrial ochre mutation oxi 1-V25. The base changes leading to the suppression effect have not been identified. AT----GC base substitutions in mitochondrial genomes are inefficiently induced by EMS. The RAD9 and REV3 gene products participate in EMS mutagenesis in nuclear, as well as mitochondrial genomes of yeast.
mesh_terms: D005020:Ethyl Methanesulfonate / Q000494:pharmacology*; D005800:Genes, Fungal / Q000187:drug effects*; D005838:Genotype; D008928:Mitochondria / Q000187:drug effects*; D009154:Mutation; D013045:Species Specificity; D013489:Suppression, Genetic / Q000187:drug effects
chemical_list: D005020:Ethyl Methanesulfonate