Histologic consequences of inferior oblique anastomosis to denervated lateral rectus muscle.
Secondary muscular neurotization has been proposed as a means of restoring contractility to paretic extraocular muscle. We studied this technique by anastomosing healthy inferior oblique muscle to lateral rectus muscle that had been denervated either orbitally or intracranially in 20 dogs. Nerve and muscle fiber growth from the inferior oblique to the lateral rectus was demonstrated but no new neuromuscular junctions were formed. Regeneration of the lesioned sixth nerve occurred frequently and may explain the restoration of function claimed after this procedure.
D000818:Animals; D004285:Dogs; D009121:Muscle Denervation; D009801:Oculomotor Muscles / Q000294:innervation* / Q000601:surgery; D009886:Ophthalmoplegia / Q000601:surgery*; D013285:Strabismus / Q000601:surgery