Morphometric evidence that the maturation of the eosinophil granules is independent of volume change.
Rat bone marrow cells and peritoneal eosinophils have been used to study by quantitative microscopy the granule morphological maturation. The analysis demonstrated a periodic, multimodal granule volume distribution, in both sources. In addition, by using graph smoothing methodology (moving bin technique) we deduced that the basic volume quanta is equal in both cases, and therefore we suggest that the turning of the vesiculated young eosinophil granules into a mature dense one is dependent on intragranule processes rather than significant volume change.
D000818:Animals; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004804:Eosinophils / Q000648:ultrastructure*; D006410:Hematopoiesis; D008854:Microscopy, Electron; D051381:Rats