[Electron factors in the properties of cytochrome P-450 and mechanism of activation of molecular oxygen].
A quantum-chemical calculation was carried out for the electronic structures of coordination compounds of general formula: FeP(L1)(L2) (P--porphin; L1 = SHCH3, [SCH3]-, [SC6F4H]-; L2 = CO, NO, O2), modeling the active site of cytochrome P450. It was shown that Coulomb repulsion between the electrons of the sulfur lone pair leads to the transfer of the electronic density from the ligands L1 = [SCH3]- or [SC6F4H]- to the porphyrin of/and to the L2 ligand. This explains the origin of the band at 450 nm in the absorption spectra of the complexes of cytochrome P450 with CO, the absence of such a band in those with O2, and the strong activation of dioxygen by cytochrome P450.
D003577:Cytochrome P-450 Enzyme System / Q000032:analysis*; D004579:Electron Transport; D008024:Ligands; D008956:Models, Chemical; D010100:Oxygen
D008024:Ligands; D003577:Cytochrome P-450 Enzyme System; D010100:Oxygen
Elektronnye faktory v svoĭstvakh tsitokhroma P-450 i mekhanizmy aktivatsii molekuliarnogo kisloroda.