Sister-chromatid exchanges in newborns after normal and progesterone-treated pregnancies.
Two groups of newborns were selected for SCE analyses, one consisting of infants born after progesterone-treatment during pregnancy (PTP) and a control group. A slight, but statistically significant difference in the number of SCEs was found: in the control group 5.55 +/- 0.62, and in the PTP group 7.99 +/- 0.88. This effect also proved to be true in an in vitro system, where various concentrations of progesterone were tested. The authors offer two possible explanations: one involving the biochemical pathways of progesterone and the influence on the level of excretory products; the other involving a direct relationship between progesterone and DNA.
D004249:DNA Damage; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008214:Lymphocytes / Q000648:ultrastructure; D008431:Maternal-Fetal Exchange; D010197:Pancuronium / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D011374:Progesterone / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D011374:Progesterone; D010197:Pancuronium; C003549:dacuronium