Effects of oxamniquine on chick isolated esophagus.
The effects of oxamniquine, a potent schistosomicide, on chick isolated esophagus have been examined. Oxamniquine (2.5 X 10(-8)-5 X 10(-5) M) caused rhythmic and tonic contractions of the chick isolated esophagus. The concentration of oxamniquine required to produce 50% of the maximal contractile response (EC50) was 4.2 X 10(-5) M. Pre-incubation of the muscle preparation with procaine (40-120, microM), scopolamine (0.40 microM) or indomethacin (10 microM) attenuated oxamniquine-induced myogenic contractions of the muscle preparation. It is suggested that inhibition of oxamniquine-induced contractions by indomethacin, scopolamine or procaine probably indicates that oxamniquine-induced contractions of the muscle preparation is due to the release of a prostaglandin-like substance and/or a yet unknown contractile compound from the muscle.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002645:Chickens; D004947:Esophagus / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009600:Nitroquinolines / Q000494:pharmacology*; D010073:Oxamniquine / Q000494:pharmacology*
D009600:Nitroquinolines; D010073:Oxamniquine; D002118:Calcium