Serotoninergic neurons: long-lasting activation by a possible antidepressant dihydroergosine.
The duration of the stimulating effect of one single i.p. injection of a possible antidepressant dihydroergosine (50 mg/kg) on the 5-HT syndrome was studied in rats. Dihydroergosine produced a very pronounced stimulation of the 5-HT syndrome which was still present after 1-144 h (6 days). The results suggest that dihydroergosine produces a long-lasting stimulation of serotoninergic neurons.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D004879:Ergotamines / Q000494:pharmacology*; D008297:Male; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D013577:Syndrome
D000928:Antidepressive Agents; D004879:Ergotamines; D011985:Receptors, Serotonin; C037580:9,10-dihydroergosine; D010293:Pargyline