title: [Fosfomycin levels in the cerebrospinal fluid of patients with and without meningitis].
abstract: 18 neurosurgical patients were given 15 g fosfomycin at 8-hour intervals. Simultaneously serum and cerebrospinal fluid (CSF) concentrations were determined periodically over 8 hrs. In patients with noninflamed meninges the CSF-concentrations ranged between 6.48 and 8.98 micrograms/ml. In patients with meningitis the CSF-levels amounted to 20.28 and 39.80 micrograms/ml. For perioperative short-time prophylaxis and postoperative infections in neurosurgical patients therapeutically relevant fosfomycin levels against Staph. aureus und Staph. epidermidis can be achieved.
mesh_terms: D000293:Adolescent; D000328:Adult; D001812:Blood-Brain Barrier; D004351:Drug Resistance; D005260:Female; D005578:Fosfomycin / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D008875:Middle Aged
chemical_list: D005578:Fosfomycin
vernacular_title: Fosfomycinspiegel im Liquor bei Patienten mit und ohne Meningitis.