Studies on immunological effects of pyran. 1. Enhancement of antibody production in mice.
Pyran, when administered intravenously, enhanced antibody production in mice. The optimal dose seemed to be about 10 mg/kg body weight. Antibody titers of normal mice inoculated with pyran are usually 2 to 8 times higher than those of mice inoculated with normal saline. However, pyran does not affect antibody production significantly by oral administration or intraperitoneal inoculation. When mice are immunologically suppressed by cyclophosphamide and then receive antigen together with pyran, their antibody titers are as high as non-immunologically suppressed ones'. In other words, Pyran can relieve the immunosuppression exerted by cyclophosphamide. The finding suggests that Pyran may be of value in reducing microbial infection in patients who received immunosuppressive antineoplastic agents.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003520:Cyclophosphamide / Q000494:pharmacology; D004365:Drugs, Chinese Herbal; D006460:Hemolysin Proteins / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D006460:Hemolysin Proteins; D010936:Plant Extracts; C052895:pyran, Pyrus pyrofolia Nak; D003520:Cyclophosphamide