Adrenal androgens, sex-hormone binding globulin and bone density in osteoporotic menopausal women: is there a relationship?
The relationships among sex steroids, sex hormone binding globulin (SHBG) and vertebral bone density as measured by computerized tomography were studied in 18 post-menopausal women. A significant negative correlation was found between SHBG binding capacity (SHBG-BC) and bone density. Bone density and the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) declined with age, and SHBG-BC was correlated significantly with DHEAS concentrations. The relationship between SHBG-BC and bone density may be affected by adrenal androgen output.
D000305:Adrenal Cortex Hormones / Q000097:blood*; D000368:Aged; D000728:Androgens / Q000097:blood*; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D005260:Female; D006801:Humans; D008593:Menopause / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000209:etiology*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*
D000305:Adrenal Cortex Hormones; D000728:Androgens; D012738:Sex Hormone-Binding Globulin; D002118:Calcium