title: Effects of systemic and intracranial amphetamine injections on behavior in the open field: a detailed analysis.
abstract: Systemic injections of amphetamine result in profound changes in the behavior of animals in an open field. There is an increase in activity, certain species-typical behaviors are produced, and there is a tendency for any elicited behavior to be repeated in a stereotyped way. The present study examined the contributions of dopamine terminal regions to these effects in rats by microinjecting amphetamine directly into one of six discrete sites (medial frontal cortex, nucleus accumbens, anteromedial caudate nucleus, ventrolateral caudate nucleus, amygdala, or the region surrounding the area postrema) and making detailed behavioral observations. This data was compared with the behavior of systemically injected rats that were also observed in the open field. An observer recorded the occurrence of twelve categories of behavior and recorded photocell beam interruptions during five post-injection observation periods. The results confirmed and extended previous accounts of the behavior of systemically injected rats, adding increased snout contact with the environment as an additional effect of amphetamine. Intracranial injections produced changes in activity level from several of the injection sites but there was no increase in the species-typical behaviors associated with stereotypy. Changes in the occurrence of some recorded behaviors were produced by injections into most of the sites and these data are presented in detail.
mesh_terms: D000661:Amphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D002421:Caudate Nucleus / Q000187:drug effects; D005625:Frontal Lobe / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009714:Nucleus Accumbens / Q000187:drug effects; D051381:Rats
chemical_list: D000661:Amphetamine