Gas chromatographic analysis of phenylethylmalonamide in human plasma.
A method is described for the analysis of phenylethylmalonamide in human plasma. Analysis of plasma requires only 200 microliter of sample which is extracted with dichloroethane. After filtration and evaporation of the solvent the residue is reconstituted in 50 microliter of chloroform and 5 microliter are injected onto the gas chromatograph. The column used is a mixture of CDMS/WG11 coated on Chromosorb W HP 100-120 mesh. The method is suitable for use in single-dose pharmacokinetic studies.
D000927:Anticonvulsants / Q000097:blood; D002849:Chromatography, Gas; D006801:Humans; D007202:Indicators and Reagents; D008314:Malonates / Q000097:blood*; D010657:Phenylethylmalonamide / Q000097:blood*; D011324:Primidone / Q000097:blood; D011786:Quality Control
D000927:Anticonvulsants; D007202:Indicators and Reagents; D008314:Malonates; D011324:Primidone; D010657:Phenylethylmalonamide