Metabolism of hexachlorobenzene by rat-liver microsomes.
Hexachlorobenzene (HCB) was metabolized to dechlorinated and hydroxylated products by the mixed-function oxidase system of rat-liver microsomes (phenobarbital- or 3-methylcholanthrene-induced). Metabolites were identified by gas-liquid chromatography-mass spectrometry. 14C-HCB was bound to microsomal protein. No explanation was found for the sex-dependent hepatotoxicity of HCB in rats.
D000818:Animals; D002722:Chlorobenzenes / Q000378:metabolism*; D005260:Female; D006581:Hexachlorobenzene / Q000378:metabolism*; D006900:Hydroxylation; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344
D002722:Chlorobenzenes; D006581:Hexachlorobenzene