Is the purinergic system involved in the control of pathological movements?
The EEG and behavioral effects of caffeine, carbamazepine and haloperidol were assessed in adult male rabbits. Caffeine (50 mg/kg i.v.) induced a long-lasting EEG desynchronization (45.6/60 min in mean) which was not modified by pretreatment of the rabbits with carbamazepine or haloperidol. All these drugs, administered alone, failed to induce stereotypy in rabbits. The administration of caffeine in combination with carbamazepine and/or haloperidol induced stereotyped behavior.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002220:Carbamazepine / Q000494:pharmacology; D004569:Electroencephalography; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D011687:Purines / Q000502:physiology*; D011817:Rabbits; D013239:Stereotyped Behavior / Q000187:drug effects / Q000502:physiology*
D011687:Purines; D002220:Carbamazepine; D002110:Caffeine; D006220:Haloperidol