Effect of bromocriptine on the ovarian cycle of two inbred strains of mice.
Mice of the C3H/Sy (high incidence of spontaneous mammary cancer) and AKR/Sy (low incidence of spontaneous mammary cancer) inbred strains, which have different hormonal profiles, were injected daily with bromocriptine for 1 month. The treatment increased the duration of the ovarian cycle of the AKR/Sy mice, whereas that of the C3H/Sy mice was not affected. It is suggested that the effect of bromocriptine on the ovarian cycle depends on the concentrations of plasma progesterone reached in each strain of mouse.
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D010053:Ovary / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D013045:Species Specificity
D001971:Bromocriptine