[Partial response of lung metastases from a renal cancer treated with endogenous tumor necrosis factor].
The strong tumor-selective cytocidal action of tumor necrosis factor (TNF) has been observed in vitro and in vivo. Sato et al. have reported that it was possible to induce a primed state of TNF triggering by injection of purified protein derivative (PPD) even a long time after BCG sensitization, suggesting that this treatment could be applied to human patients. In the present study, we achieved a partial response of a metastatic lesion in a patient with renal cancer by the induction of endogenous TNF by PPD and OK-432 (a streptococcal preparation). This study suggested the possible application of this therapy to also patients with malignant tumor which are highly resistant to any conventional antitumor therapy.
D001688:Biological Products / Q000008:administration & dosage*; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D007680:Kidney Neoplasms; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010844:Picibanil / Q000008:administration & dosage*; D014373:Tuberculin / Q000008:administration & dosage*; D014409:Tumor Necrosis Factor-alpha
D001688:Biological Products; D006023:Glycoproteins; D014373:Tuberculin; D014409:Tumor Necrosis Factor-alpha; D010844:Picibanil