title: A comparison of the hemodynamic responses of systematic and uteroplacental vasculature to angiotensin in conscious guinea pigs.
abstract: Hemodynamic studies were performed in 11 conscious pregnant guinea pigs using radioactive microspheres to calculate the effects of angiotensin II (AII) infusion. A dose-dependent increase of the mean arterial pressure and systemic vascular resistance during AII infusion was observed. A significant increase in in uteroplacental flow also occurred without a change in cardiac output or uteroplacental vascular resistance. These data demonstrate that the systemic and uterine vasculatures of the pregnant guinea pig have different responses to AII infusion.
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002395:Catecholamines / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects*; D008863:Microspheres; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood / Q000502:physiology*; D012039:Regional Blood Flow / Q000187:drug effects; D014599:Uterus / Q000098:blood supply*
chemical_list: D002395:Catecholamines; D000804:Angiotensin II