[Effect of the administration of large doses of iron on the morphologic picture of various internal organs of piglets].
Iron overload lesions were described in various cells and tissues. Piglets of the group I were given 3.5 ml irondextrandaily (Ferrodex-Polfa) containing 250 mg Fe intraperitoneally during 14 consecutive days. Piglets of this group were sacrificed and examined: I A--just after last injection, I B--after 5 weeks since the last injection, I C--after 6 weeks since the last injection. The II group were control animals. The examined organs were: kidney, spleen, lymph nodes, lung, liver, muscles, heart, jejunum and brain. The following conclusions were drawn: 1) Ferrodex overload caused deposition of iron in reticulo--macrophage system, but not in parenchymal cells. 2) Ferrodex excess caused minimal risk to animal health, as seen as a slight damage, or lack of it, in liver, heart, muscles, lung, brain and jejunum. 3) The only significant lesion were observed in the glomeruli, where due to iron overload focal chronic glomerulonephritis were found.
D000818:Animals; D007501:Iron / Q000008:administration & dosage* / Q000378:metabolism; D008854:Microscopy, Electron; D013552:Swine / Q000033:anatomy & histology* / Q000378:metabolism
D007501:Iron
Wpływ podawania duzych dawek zelaza na obraz morfologiczny niektórych narzadów wewnetrznych u prosiat.