A method for the continuous measurement of respiration and vapor uptake in rats.
A method for determining the uptake of inhaled vapors in rats is described. The method uses gas chromatographic data to enable calculations of vapor concentration differences upstream and downstream from a rat exposed to the vapor by the nose-only route. Respiratory data are recorded simultaneously. The data can be used to determine the rate of uptake, uptake as a fraction of vapor inhaled and the effects of vapor inhalation on respiration.
D000280:Administration, Inhalation / Q000295:instrumentation*; D000818:Animals; D002849:Chromatography, Gas; D008297:Male; D008838:Microcomputers; D010420:Pentanes / Q000378:metabolism / Q000633:toxicity; D010991:Plethysmography; D051381:Rats; D012119:Respiration; D012129:Respiratory Function Tests / Q000295:instrumentation
D010420:Pentanes; C053045:2,3,4-trimethylpentane