[Properties of glycoprotein 125, a proliferation-associated cell surface antigen].
A cell surface antigen expressed in association with cell proliferation was detected and identified as a glycoprotein of molecular weight of 125,000 (gp 125) by using monoclonal antibodies against human or rat bladder cancer cells. We have found that appearance of the antigen in stimulated lymphocytes precedes the emergence of interleukin 2 receptor and that it is regulated by Ca ion and protein kinase-C.
D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000302:isolation & purification*; D002118:Calcium / Q000502:physiology; D002453:Cell Cycle; D006023:Glycoproteins / Q000302:isolation & purification*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008970:Molecular Weight; D011494:Protein Kinases / Q000502:physiology; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D006023:Glycoproteins; D011494:Protein Kinases; D002118:Calcium