[Disulfiram inhibition of aldehyde reductase from the rat liver].
Disulphiram (tetraethylthiuram disulphide teturam, antabus), the known antialcoholic preparation, is studied for its effect on the aldehyde reductase activity (EC 1.1.1.1) in the rats' liver. Apparent Km and V are calculated for acetylaldehyde and NADH as well as Ki of disulphiram relative to the substrate and cofactor of the enzyme. The obtained data permit considering disulphiram a high-specific inhibitor of aldehyde reductase in rats' liver.
D000426:Alcohol Dehydrogenase / Q000037:antagonists & inhibitors*; D000818:Animals; D004221:Disulfiram / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats
D000426:Alcohol Dehydrogenase; D004221:Disulfiram
Ingibirovanie disul'firamom al'degidreduktazy pecheni krys.