title: Involvement of sympathetic nervous system inhibition in the hypotensive effect of bromocriptine in spontaneously hypertensive rats.
abstract: The hypotensive effect of bromocriptine in young (6 week old) spontaneously hypertensive rats (SHR) was studied. Blood pressure and plasma norepinephrine level in bromocriptine-treated SHR were significantly lower than those in vehicle-treated SHR after 3 weeks of treatment (5 mg/kg per day, i.p.), while no significant decrease of blood pressure or plasma norepinephrine level was observed after 2 weeks of treatment. These results suggest the involvement of sympathetic nervous system inhibition in the hypotensive effect of bromocriptine in SHR.
mesh_terms: D000375:Aging / Q000097:blood; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004837:Epinephrine / Q000097:blood; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D011918:Rats, Inbred SHR; D013564:Sympathetic Nervous System / Q000187:drug effects*
chemical_list: D001971:Bromocriptine; D009638:Norepinephrine; D004837:Epinephrine