Anticonvulsant activity of indanylspirosuccinimide Mannich bases.
A series of Mannich bases derived from spiro [indan-1,3'pyrrolidine-2',5'-dione] were evaluated for anticonvulsant activity. This activity varied as a function of the amine substituent and several compounds showed protective effects in both the maximal electroshock (MES) and subcutaneous pentylenetetrazol (scMet) assays. In addition, fluorenyl- and cyclopentyl-derived spirosuccinimides, as well as extended chain analogues, were tested and proved to be inactive. A time versus effect study was conducted employing the MES assay and the hydroxyethylpiperazine-derived Mannich base of spiro [indan-1,3 pyrrolidine-2',5',dione]. This compound acted rapidly and its protective half-life was increased as larger doses were administered.
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D007189:Indans / Q000494:pharmacology*; D007192:Indenes / Q000494:pharmacology*; D008352:Mannich Bases / Q000494:pharmacology*; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors
D000588:Amines; D000927:Anticonvulsants; D007189:Indans; D007192:Indenes; D008352:Mannich Bases; D010433:Pentylenetetrazole