[Morphologic findings after intracerebral administration of an alcoholic prolamine solution].
Morphological studies were performed after intracerebral injection of Ethibloc (E.), an alcoholic prolamine solution, to prove the usefulness of E. as a drug depot in the local chemotherapy of brain gliomas. Organisation of E. starts 2-3 weeks after injection, but remains incomplete even 24 weeks later. This depot cannot be removed in case of diminished drug concentration because of the extremely close connection with the adjacent brain tissue. Further repeated injection of drug into the E. depot cannot reach the tumours periphery because of the surrounding glial scar and connective tissue.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D003973:Diatrizoate; D004338:Drug Combinations; D005227:Fatty Acids; D007267:Injections; D008297:Male; D011409:Propylene Glycols; D011506:Proteins / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D015028:Zein
D004338:Drug Combinations; D005227:Fatty Acids; D011409:Propylene Glycols; D011506:Proteins; D003973:Diatrizoate; D015028:Zein; C020481:alcoholic prolamine solution
Morphologische Befunde nach intrazerebraler Applikation einer alkoholischen Prolaminsäurelösung.