Pharmaceutical availability from oral dosage forms: in vitro release of nitrofurantoin from tablets and capsules.
The pharmaceutical availability of nitrofurantoin in three commercial urinary antiseptic preparations for oral use was assessed by an in vitro determination of drug release into a strongly acidic, a weakly acidic and a weakly basic medium. The following parameters are reported: t87.5%, tdiss, X0 (percentage released immediately on contact with medium), krel (relative dissolution rate constant), and dissolution efficiency (DE).
D001682:Biological Availability; D002214:Capsules; D006863:Hydrogen-Ion Concentration; D009582:Nitrofurantoin / Q000008:administration & dosage* / Q000378:metabolism; D013607:Tablets
D002214:Capsules; D013607:Tablets; D009582:Nitrofurantoin