title: The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani.
abstract: Several alkyl phosphorylcholines and related derivatives were tested against Leishmania donovani amastigotes in mouse peritoneal macrophages in vitro and ED50 values were determined in the range of 1-12 microM. The three alkyl phosphorylcholines tested against L. donovani in BALB/c mice were active, an ED50 of 12.8 mg/kg/day X 5 was ascertained for one compound, but an alkyl phosphorylethanolamine was inactive.
mesh_terms: D000478:Alkylation; D000818:Animals; D002794:Choline / Q000031:analogs & derivatives*; D007893:Leishmania donovani / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D010767:Phosphorylcholine; D002794:Choline