title: Chromosomal aberrations in early stages of development of methotrexate resistance in HeLa cells.
abstract: High incidence of dicentrics, rings, double rings, acentric rod-like fragments and double minutes in polyploid cells during the early stages of development of methotrexate resistance in HeLa cells suggests that hypertetraploid cells are precursors of cells with higher resistance levels.
mesh_terms: D002869:Chromosome Aberrations; D004351:Drug Resistance; D006367:HeLa Cells; D006801:Humans; D008727:Methotrexate / Q000494:pharmacology*
chemical_list: D008727:Methotrexate