[Spectrophotometric determination of amikacin and sisomicin in the air using the Hantzsch reaction].
A procedure for determination of amikacin and sisomicin in ambient air of production areas was developed. It is based on the Hantzsch reaction involving formation of dihydrolutidine derivatives on the antibiotic interaction with acetyl acetone and formaldehyde in acid media. The yellow-colored reaction products are subjected to spectrophotometry at 356 nm. The detection limits for amikacin and sisomicin are 0.005 and 0.01 mg respectively. The procedure may be used for routine sanitary inspection of ambient air for every of the above antibiotics in the absence of the other in production of the substances and their dosage forms.
D000395:Air Pollutants, Occupational / Q000032:analysis*; D000583:Amikacin / Q000032:analysis*; D003124:Colorimetry; D012853:Sisomicin / Q000032:analysis*; D013053:Spectrophotometry
D000395:Air Pollutants, Occupational; D000583:Amikacin; D012853:Sisomicin
Spektrofotometricheskiĭ metod opredeleniia amikatsina i sizomitsina v vozdukhe s ipol'zovaniem reaktsii Gancha.