Synthesis of 7 beta-(4-oxo-3,4-dihydrothieno[2,3-d] pyrimidyl-2-thioacetamido)cephalosporanic acid derivatives.
Synthesis of new cephalosporins possessing thieno [2,3-d]pyrimidine is described in the present paper. Potassium salts of 2-thio-4-oxo-3,4-dihydrothieno [2,3-d]pyrimidines, which gave then 2-carboxymethylmercapto-4-oxo-3,4-dihydrothieno [2,3-d]pyrimidines, were prepared from 2-amino-3-carbethoxythiophene derivatives. These compounds were allowed to react with 7-aminocephalosporamic acid (ACA) benzhydryl esters or with 7 beta-chloroacetamidocephalosporanic acid derivatives to obtain new cephalosporins. Antibacterial activities of these new cephalosporins are summarized in the present paper as well.
D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
D000890:Anti-Infective Agents; D002511:Cephalosporins; D011743:Pyrimidines