Involvement of the central nervous system in malignant lymphomas of mice.
19% of the male and 49% of the female AKR mice with spontaneously developed lymphomas show an involvement of the central nervous system (CNS) in the form of a tumor cell infiltration of the leptomeninx. A significantly higher rate of lymphomas was achieved by syngeneic transplantation of lymphoma cells (intraperitoneal inoculation) in the CNS with 87% in both sexes. Morphologically, there were no differences between the leptomeningeal infiltrations in spontaneously developed and transplanted lymphomas. Spontaneous and induced lymphomas of the AKR mouse may be suitable as a simple model for investigations on CNS lymphomas in experimental oncology.
D000367:Age Factors; D000818:Animals; D005260:Female; D008207:Lymphatic Metastasis; D008223:Lymphoma / Q000473:pathology* / Q000556:secondary; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D009368:Neoplasm Transplantation; D009423:Nervous System Neoplasms / Q000556:secondary*; D012737:Sex Factors; D013953:Thymus Neoplasms / Q000556:secondary