The metabolism of 2,3,4-trimethylpentane in male Fischer-344 rats.
The urinary metabolites of the potent nephrotoxic hydrocarbon 2,3,4-trimethylpentane (2,3,4-TMP) given Fischer-344 male rats by gavage included 1-hydroxy-2,3,4-trimethylpentane, 2,3,4-trimethyl-1-pentanoic acid and 2,3,4-trimethyl-5-hydroxy-1-pentanoic acid. Analyses were performed by gas-liquid chromatography (GC) and gas-liquid chromatography/mass spectrometry (GC/MS). A comparison of the urinary metabolites of 2,3,4-TMP with those of 2,2,4-trimethylpentane (2,2,4-TMP) showed that more monocarboxylic acid was produced with 2,3,4-TMP.
D000818:Animals; D001711:Biotransformation; D002849:Chromatography, Gas; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D009795:Octanes / Q000652:urine; D010420:Pentanes / Q000652:urine*; D051381:Rats; D011916:Rats, Inbred F344
D009795:Octanes; D010420:Pentanes; C045798:2,2,4-trimethylpentane; C053045:2,3,4-trimethylpentane