On the mechanism of the smooth-muscle action of rosanol.
In vivo and in vitro experiments were performed to clarify some aspects of the mechanism of the smooth-muscle action of rosanol prepared from rose oil. On dogs (in vivo) and on isolated segments from guinea-pig ileum (in vitro) rosanol at high doses exerted a slight inhibitory effect on the activated gastrointestinal motility. The cholinolytic rosanol action proved in in vitro experiments, was found to play an essential role in the mechanism of its gastrointestinal motility-inhibiting effect. The present studies showed a pronounced antagonistic effect of rosanol on the KCl-increased Ca2+ level in rabbit aorta. It might be suggested that this effect of rosanol is also involved in the inhibitory action of rosanol on the activated gastrointestinal motility.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D004285:Dogs; D004338:Drug Combinations / Q000494:pharmacology; D004558:Electric Stimulation; D005769:Gastrointestinal Motility / Q000187:drug effects; D006168:Guinea Pigs; D009130:Muscle, Smooth / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D011817:Rabbits; D013729:Terpenes / Q000494:pharmacology*
D004338:Drug Combinations; D010936:Plant Extracts; D013729:Terpenes; D011189:Potassium Chloride; D002118:Calcium; C012026:rosanol