title: [Absorption and distribution of rokitamycin in beagle dogs].
abstract: Tissue distribution of rokitamycin (TMS-19-Q) was studied after oral administration of 50 mg/kg to fasted Beagle dogs. Tissue concentrations of TMS-19-Q reached their peaks at 1-2 hours after the administration. The order of tissue concentrations of TMS-19-Q was liver greater than kidney greater than spleen greater than lung greater than mesenteric lymph node greater than heart greater than tonsil greater than serum greater than prostate gland greater than uterus greater than skin. At the peak time, drug concentrations in tonsil and lung were about 1.1 and 1.4 times higher, respectively, than that in serum.
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D007408:Intestinal Absorption; D007933:Leucomycins / Q000378:metabolism*; D008297:Male; D015644:Miocamycin / Q000031:analogs & derivatives*; D014018:Tissue Distribution
chemical_list: D007933:Leucomycins; D015644:Miocamycin; C033383:rokitamycin