Bilateral subdiaphragmatic vagotomy does not prevent the behavioral effects of systematically administered ceruletide in mice.
To clarify the vagal mediation of behavioral changes following systematically administered CCK-like peptides, we examined the effects of subcutaneously injected ceruletide on several behavioral parameters. Ceruletide at a dose of 100 micrograms/kg reduced the rates of spontaneous locomotor activity and rearing, and also inhibited methylphenidate- and methamphetamine-induced hyperactivity in both sham-operated and vagotomized mice to same extent, whereas bilateral subdiaphragmatic vagotomy attenuated these behavioral parameters. These results indicate that the ascending sensory pathway mediating a peripheral CCK-elicited signal may not be responsible for producing the behavioral effects of systematically administered CCK-like peptides.
D000818:Animals; D002108:Ceruletide / Q000008:administration & dosage / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D008774:Methylphenidate / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects; D014628:Vagotomy
D008774:Methylphenidate; D008694:Methamphetamine; D002108:Ceruletide