In vitro activity of paldimycin (U-70138F) against gram-positive bacteria isolated from patients with cancer.
The in vitro activity of paldimycin, a novel antimicrobial agent, was compared with that of vancomycin against 306 gram-positive isolates (representing 12 bacterial species) obtained from patients with cancer. Paldimycin had lower MICs for 90% of isolates than vancomycin did against most isolates tested. Its activity, however, was medium and pH dependent, being greatest in Nutrient broth at a pH of 6.8.
D000111:Acetylcysteine / Q000031:analogs & derivatives; D001424:Bacterial Infections / Q000209:etiology / Q000382:microbiology*; D004187:Disaccharides; D006020:Glycopeptides / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D009369:Neoplasms / Q000150:complications*; D014640:Vancomycin / Q000494:pharmacology
D004187:Disaccharides; D006020:Glycopeptides; D014640:Vancomycin; C050461:paldimycin; D000111:Acetylcysteine