A case of panic disorder precipitated by oxymetazoline withdrawal.
Abrupt withdrawal in a healthy man of oxymetazoline nasal spray precipitated a prolonged panic disorder that required hospitalization with extensive evaluations. The pathophysiology of this syndrome is discussed in light of locus ceruleus neuropharmacology. This may be the first report of such a withdrawal syndrome.
D001008:Anxiety Disorders / Q000139:chemically induced*; D005239:Fear; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010109:Oxymetazoline / Q000009:adverse effects*; D010200:Panic; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D007093:Imidazoles; D010109:Oxymetazoline