Increase of in vitro brain [3H]muscimol binding after L-homocysteine administration to rat.
L-Homocysteine intraperitoneal injections to the rat induced 50-70% inhibition of phosphatidyl-N-methyltransferase activity. A 30-40% increase of muscimol (a gamma-aminobutyric acid (GABA) agonist) binding was observed; Scatchard plot analysis showed an increase of the number of sites. [3H]Diazepam binding was not modified.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism; D006710:Homocysteine / Q000494:pharmacology*; D007700:Kinetics; D009118:Muscimol / Q000378:metabolism*; D051381:Rats
D006710:Homocysteine; D009118:Muscimol; D003975:Diazepam