[State of the antioxidant system during corazole kindling in rats].
Antioxidation system was investigated in rats during kindling formation caused by daily administration of corazole in under-threshold doses. No changes have been observed in the activity of superoxide dismutase, glutathione peroxidase, glutathione reductase and alpha-tocopherol content in the rat brain and blood. It is suggested that corazole-induced predisposition to epileptic activity is formed by mechanisms which are not associated with lipid metabolism in nervous tissue.
D000818:Animals; D000975:Antioxidants; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D005980:Glutathione Reductase / Q000097:blood / Q000378:metabolism; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D014810:Vitamin E / Q000097:blood / Q000378:metabolism
D000975:Antioxidants; D014810:Vitamin E; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D010433:Pentylenetetrazole
Sostoianie antioksidantnoĭ sistemy pri korazolovom kindlinge u krys.