title: Vascular pathogenesis of unilateral craniofacial defects.
abstract: The term hemifacial microsomia refers to unilateral defects in development of structures derived from the first and second branchial arches. Recently we evaluated three unrelated children who had a similar pattern of unilateral craniofacial defects that was associated with other structural abnormalities having a disruptive vascular pathogenesis. The clinical findings in these patients suggest that one cause of hemifacial microsomia is in utero interruption of blood flow.
mesh_terms: D000293:Adolescent; D001934:Branchial Region / Q000098:blood supply*; D002339:Carotid Arteries / Q000002:abnormalities / Q000000981:diagnostic imaging; D002675:Child, Preschool; D005147:Facial Bones / Q000002:abnormalities*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008850:Microphthalmos / Q000209:etiology; D011859:Radiography; D012886:Skull / Q000002:abnormalities*; D013577:Syndrome