Effect of galactose and isosorbide on cochlear blood flow.
Cochlear blood flow in the rabbit was determined before and after injection of hyperosmotic solutions of galactose and isosorbide. After doses similar to those which can produce hearing improvements in patients with Ménière's disease, cochlear blood flow was increased by 30-60%.
D000818:Animals; D003051:Cochlea / Q000098:blood supply* / Q000187:drug effects; D005260:Female; D005690:Galactose / Q000494:pharmacology*; D007547:Isosorbide / Q000494:pharmacology*; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D013012:Sorbitol / Q000031:analogs & derivatives*
D013012:Sorbitol; D007547:Isosorbide; D005690:Galactose