title: C-reactive protein in dogs.
abstract: Serum concentrations of C-reactive protein (CRP) in dogs with various diseases or undergoing various procedures were measured by specific immunoassay. In 20 healthy dogs from various sources, values were all less than 5 mg/L, but in 22 healthy dogs from a single source, values ranged from less than 5 mg/L in 14 dogs and from 8 to 67 mg/L in 8 dogs. Increased concentrations of serum CRP were attained 24 hours after injection of casein (n = 9; median 188 mg/L), ovariohysterectomy (n = 11; median, 144 mg/L), or elective, nonacute orthopedic surgery (n = 10; median, 83 mg/L). After inoculation of Leptospira interrogans serovar canicola (n = 5), the behavior of serum CRP as an acute-phase reactant provided a sensitive and precise objective reflection of in vivo response. The CRP concentration in random single-serum samples from 73 dogs with other inflammatory and noninflammatory disorders ranged from normal (less than 5 mg/L) to 246 mg/L and generally correlated with the extent and activity of disease.
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000662:veterinary; D002097:C-Reactive Protein / Q000032:analysis*; D002364:Caseins / Q000494:pharmacology; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs / Q000097:blood* / Q000601:surgery; D010188:Exocrine Pancreatic Insufficiency / Q000097:blood / Q000662:veterinary; D005260:Female; D007922:Leptospirosis / Q000097:blood / Q000662:veterinary; D008286:Malabsorption Syndromes / Q000097:blood / Q000662:veterinary; D008297:Male
chemical_list: D002364:Caseins; D002097:C-Reactive Protein