Demonstration of the release of an epithelium-derived inhibitory factor from a novel preparation of guinea-pig trachea.
Using a novel preparation of guinea-pig trachea, direct evidence was obtained for the release of an epithelium-derived inhibitory factor modulating contractions elicited by antigen. Thus, epithelium removal produced a 6.1-fold leftward shift in ovalbumin concentration-response curves in tracheal strips from ovalbumin-sensitized guinea-pigs. This increase in sensitivity to ovalbumin was not evident when a tracheal portion containing epithelium was positioned in close proximity to the tissue from which tension was recorded.
D000403:Airway Resistance; D000818:Animals; D004848:Epithelium / Q000378:metabolism / Q000502:physiology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000503:physiopathology; D014132:Trachea / Q000378:metabolism* / Q000503:physiopathology
D010047:Ovalbumin