title: GABAergic inhibition increases the neuronal selectivity to natural sounds in the avian auditory forebrain.
abstract: The influence of the iontophoretically applied GABA antagonist bicuculline-methiodide (BIC) on single cell selectivity to natural sounds in the auditory forebrain was studied in awake chickens. Units in the thalamo-recipient lamina showed no clear changes in neuronal selectivity during BIC application, while cells postsynaptic to this layer displayed a clear loss of response selectivity. The results are discussed in regard to the role of GABA-mediated inhibition in auditory processing within the telencephalon.
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001307:Auditory Perception / Q000502:physiology*; D001640:Bicuculline / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D002645:Chickens / Q000502:physiology*; D018756:GABA Antagonists; D007478:Iontophoresis; D009433:Neural Inhibition; D014828:Vocalization, Animal / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D018756:GABA Antagonists; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline