Neutrophil chemotaxis in sickle cell anaemia, sickle cell beta zero thalassaemia, and after splenectomy.
Neutrophil chemotaxis was evaluated in 28 patients with sickle cell anaemia, 10 patient with sickle cell beta zero thalassaemia, 25 patients who had undergone splenectomy, and 38 controls. The mean distance migrated by patients' neutrophils was not significantly different from that of neutrophils from controls. Although several immunological variables have been reported to be changed after loss of splenic function, we were unable to show a defect in neutrophil chemotaxis that could account for the increased susceptibility to infection.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000503:physiopathology*; D002634:Chemotaxis, Leukocyte; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000503:physiopathology; D013103:Spherocytosis, Hereditary / Q000601:surgery; D013154:Spleen / Q000503:physiopathology; D013156:Splenectomy; D013161:Splenic Rupture / Q000601:surgery; D013789:Thalassemia / Q000503:physiopathology*