Ultrastructural changes in the respiratory tract of rats following methyl isocyanate inhalation.
The static exposure of rats to 0.25 mg/l methyl isocyanate for 1 h resulted in damage to the epithelium of the proximal bronchioles and upper airways. Bronchiolar cells exhibited both nuclear and cytoplasmic damage; many epithelial cells, particularly in the bronchi and trachea, were killed and/or dislodged from the basement membrane. A "raft" of cell debris and fibrin lined most of the airways during the 1st week after exposure but repair to the underlying epithelium was well advanced within 2-3 days. The majority of airways were lined by a normal epithelium within 3 weeks of exposure, but isolated foci of hyperplasia and occluded airways probably accounted for continued respiratory impairment.
D000818:Animals; D004848:Epithelium / Q000648:ultrastructure; D017879:Isothiocyanates; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D012137:Respiratory System / Q000187:drug effects* / Q000648:ultrastructure; D013861:Thiocyanates / Q000633:toxicity*
D017879:Isothiocyanates; D013861:Thiocyanates; C005227:methyl isothiocyanate