Water soluble high molecular weight components from plants with potent intraocular pressure lowering activity [corrected and republished ariticle originally printed in Curr Eye Res 1987 May;6(5):733-4].
Previous work in our laboratory has shown that Cannabis sativa (marijuana) contains water-soluble, high molecular weight components that have extremely potent intraocular pressure (IOP) lowering activity. Aqueous extraction of other plants has now shown that a number of them also contain components with potent IOP lowering activity in rabbits. These include tobacco, cabbage, lettuce, several greens, Senecio anonymus, Erigeron philadelphicus, and several others. Not all plants tested were active, however, indicating that while more ubiquitous than originally thought, these materials are not apparently extractable from all plants. The chemical composition of the active fraction from tobacco was found to be different from that derived from Cannabis sativa.
D000818:Animals; D002188:Cannabis / Q000032:analysis; D002241:Carbohydrates / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D007429:Intraocular Pressure / Q000187:drug effects*; D008970:Molecular Weight; D010936:Plant Extracts / Q000494:pharmacology*; D010944:Plants / Q000032:analysis; D010947:Plants, Toxic; D011817:Rabbits; D014026:Nicotiana / Q000032:analysis; D014675:Vegetables / Q000032:analysis
D002241:Carbohydrates; D010936:Plant Extracts