Contact allergy to the active ingredients of Kathon CG.
The preservative Kathon CG is a commercial preparation, consisting of 2 active ingredients and other components. 28 patients with contact allergy to Kathon CG participated in a study in which patch testing was performed with serial dilutions, and with 5 chromatographically separated fractions. All reacted to fraction IV, and 2 patients also to fraction II. Mass spectrometry and nuclear magnetic resonance spectrometry identified fraction II and IV to be the active ingredients; 2-methyl-4-isothiazolin-3-one and 5-chloro-2-methyl-4-isothiazolin-3-one.
D003877:Dermatitis, Contact / Q000209:etiology*; D006801:Humans; D010592:Pharmaceutic Aids / Q000009:adverse effects*; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D013844:Thiazoles / Q000009:adverse effects* / Q000302:isolation & purification / Q000633:toxicity
D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical; D013844:Thiazoles; C011506:2-methyl-4-isothiazolin-3-one; C037057:Kathon 886; C011421:5-chloro-2-methyl-4-isothiazolin-3-one