Lipstick dermatitis due to C18 aliphatic compounds.
An 18-year-old girl developed cheilitis. She had a past history of lip cream dermatitis, but the cause was not found. Patch tests with 2 lipsticks were strongly positive. Tests with the ingredients were positive to 2 aliphatic compounds, glyceryl diisostearate and diisostearyl malate. Impurities in the materials were suspected as the cause. Analysis by gas chromatography detected 3 chemicals in glyceryl diisostearate and 1 in diisostearyl malate as impurities. Patch testing with the impurities and glyceryl monoisostearate 0.01% pet in glyceryl diisostearate and isostearyl alcohol 0.25% pet in diisostearyl malate were strongly positive. The characteristics common to the 2 chemicals were liquidity at room temperature, branched C18 aliphatic compound and primary alcohol. Chemicals lacking any of the above 3 features did not react.
D000293:Adolescent; D002613:Cheilitis / Q000209:etiology*; D003358:Cosmetics / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000209:etiology*; D005233:Fatty Alcohols / Q000009:adverse effects*; D005260:Female; D005989:Glycerides / Q000009:adverse effects*; D006801:Humans
D003358:Cosmetics; D005233:Fatty Alcohols; D005989:Glycerides; C048159:glyceryl monostearate; C026199:isostearyl alcohol