title: A comparison of systemic cefuroxime and cefuroxime loaded bone cement in the prevention of early infection after total joint replacement.
abstract: A controlled prospective randomised trial of 295 arthroplasties of the hip and knee joints was carried out to compare the effect of systemic Cefuroxime with Cefuroxime in bone cement in the prevention of early infection. There was no statistical difference in the incidence of early superficial or deep infection between the two groups. Both methods of administering Cefuroxime appear to be satisfactory in the prevention of early infection after total joint replacement.
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001843:Bone Cements; D002444:Cefuroxime / Q000008:administration & dosage* / Q000627:therapeutic use; D002511:Cephalosporins / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007267:Injections; D007595:Joint Prosthesis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011897:Random Allocation; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D001843:Bone Cements; D002511:Cephalosporins; D002444:Cefuroxime