title: Acute selenium toxicosis in sheep.
abstract: Acute selenium (Se) toxicosis was evaluated in 20 female crossbred sheep, 8 to 14 mo of age. Five groups of 4 sheep each were given 0.4, 0.6, 0.7, 0.8, or 1.0 mg Se/kg body weight IM. The LD50 for sodium selenite was 0.7 mg Se/kg body weight with a standard error of 0.035 over a 192 hr observation period. The most evident clinical signs were dyspnea and depression. At necropsy, the most consistent lesions in animals which received 0.7, 0.8, and 1.0 mg Se/kg body weight were edematous lungs and pale mottled hearts. Highest tissue Se concentrations in declining order were found in the liver, kidney and heart.
mesh_terms: D000818:Animals; D005260:Female; D007700:Kinetics; D007928:Lethal Dose 50; D012643:Selenium / Q000097:blood / Q000506:poisoning*; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced* / Q000473:pathology; D014018:Tissue Distribution
chemical_list: D012643:Selenium