title: Alteration of gentamicin and cefazolin kinetics with control of the hypothyroid state in humans.
abstract: We studied the effect of the control of the hypothyroid state in humans on the pharmacokinetic parameters of cefazolin and gentamicin after a single intravenous injection. These two antibiotics were chosen because of their different patterns of binding to serum albumin (0% for gentamicin and 82% for cefazolin). In hypothyroidism, the behavior of cefazolin only was altered, with a decrease in the total body clearance, possibly due to reduced urinary excretion, and a decrease in the volume of distribution without a significant alteration of cefazolin binding to serum protein.
mesh_terms: D002437:Cefazolin / Q000378:metabolism*; D005839:Gentamicins / Q000378:metabolism*; D006801:Humans; D007037:Hypothyroidism / Q000378:metabolism*; D007700:Kinetics; D008657:Metabolic Clearance Rate; D012709:Serum Albumin / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D005839:Gentamicins; D012709:Serum Albumin; D002437:Cefazolin