[Biochemical and ultrastructural changes in the brain of the rat exposed to the cerebrospinal fluid of schizophrenics].
Using biochemical and ultrastructural methods of examination, the authors studied the brain of rats following the intracysternal injection of spinal fluid from schizophrenic patients. The elicited disorders of the ultrastructure of neurons of the medulla oblongata as well as alterations in the content of lipid peroxidation products, gangliosides and cerebrosides were directly correlated with disorders identified in the brain of schizophrenic patients. It was concluded on the basis of the results obtained that marked neurotoxic properties of schizophrenics' cerebral fluid appeared to be explained by the presence of antibodies to brain antigens.
D000818:Animals; D001323:Autoantibodies / Q000134:cerebrospinal fluid*; D001921:Brain / Q000276:immunology*; D001923:Brain Chemistry; D002554:Cerebrosides / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D005227:Fatty Acids / Q000032:analysis; D005732:Gangliosides / Q000032:analysis; D008054:Lipid Peroxides / Q000032:analysis*; D008297:Male; D008526:Medulla Oblongata / Q000648:ultrastructure*; D051381:Rats; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000276:immunology
D001323:Autoantibodies; D002554:Cerebrosides; D005227:Fatty Acids; D005732:Gangliosides; D008054:Lipid Peroxides
Biokhimicheskie i ul'trastrukturnye izmeneniia v mozge krys pri deĭstvii likvora bol'nykh shizofrenieĭ.