Genetics of male and female sterility in hybrids of Drosophila pseudoobscura and D. persimilis.
The genetic basis of male and female sterility in hybrids of Drosophila pseudoobscura-Drosophila persimilis was studied using backcross analysis. Previous studies indirectly assessed male fertility by measuring testis size; these studies concluded that male sterility results from an X chromosome-autosome imbalance. By directly scoring for the production of motile sperm, male sterility is shown to be largely due to an incompatibility between genes on the X and Y chromosomes of these two species. These species have diverged at a minimum of nine loci affecting hybrid male fertility. Semisterility of hybrid females appears to result from an X chromosome-cytoplasm interaction; the X chromosome thus has the largest effect on sterility in both male and female hybrids. This is apparently the first analysis of the genetic basis of female sterility, or of sterility/inviability affecting both sexes, in an animal hybridization.
D000818:Animals; D003433:Crosses, Genetic; D004330:Drosophila / Q000235:genetics* / Q000502:physiology; D005260:Female; D006824:Hybridization, Genetic; D007247:Infertility, Female; D007248:Infertility, Male; D008297:Male