The inheritance of a Macaca fascicularis red cell antigen detected by CAMPATH-1 antibody.
CAMPATH-1 monoclonal antibody is reactive with human lymphocytes and monocytes and it has been shown to bind to antigens on the red cells of a number of primate species, including Macaca fascicularis. Our study within a closed colony of breeding M. fascicularis monkeys has confirmed this finding, and shown that the antibody identified a single red cell antigen inherited in Mendelian fashion as a dominant character. We have, further, confirmed that the antigen is present on blood lymphocytes, even in animals whose red cells are negative. This CAMPATH-1 antigen can therefore serve as a useful red cell marker in experiments involving bone marrow transplantation or blood transfusion.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006649:Histocompatibility Antigens / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008251:Macaca / Q000276:immunology*; D008252:Macaca fascicularis / Q000097:blood / Q000235:genetics / Q000276:immunology*; D008297:Male
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D006649:Histocompatibility Antigens