Selective inhibitory effects of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl) adenine and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil on seal herpesvirus (phocid herpesvirus 1) infection in vitro.
From a selection of 25 antiviral compounds with specific anti-herpes activity or broad-spectrum antiviral properties, two compounds, namely (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil, appeared particularly effective in inhibiting the cytopathogenicity of seal herpesvirus (phocid herpesvirus 1).
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001086:Arabinofuranosyluracil / Q000031:analogs & derivatives* / Q000494:pharmacology; D002478:Cells, Cultured; D006564:Herpesviridae / Q000187:drug effects*; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D046048:Seals, Earless / Q000382:microbiology; D014529:Uridine / Q000031:analogs & derivatives*
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D001086:Arabinofuranosyluracil; C043457:fialuridine; C050127:9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine; D000225:Adenine; D014529:Uridine