Oscillations and multiple steady states in a cyclic gene model with repression.
In this paper we study the cyclic gene model with repression considered by H. T. Banks and J. M. Mahaffy. Roughly, the model describes a biochemical feedback loop consisting of an integer number G of single gene reaction sequences in series. The model leads to a system of functional differential equations. We show that there is a qualitative difference in the dynamics between even and odd G if the feedback repression is sufficiently large. For even G, multiple stable steady states can coexist while for odd G, periodic orbits exist.
D005246:Feedback; D005796:Genes; D008433:Mathematics; D008957:Models, Genetic