title: Isolated vaginal recurrences of endometrial adenocarcinoma and their management.
abstract: Eighteen patients with isolated vaginal recurrence of their previously treated endometrial carcinoma were treated with radiation therapy at North Carolina Baptist Hospital, Winston-Salem between 1971 and 1982. Most patients received external beam irradiation which were followed by boost treatments that were delivered with external beam (two patients) or intravaginal ovoid (11 patients). A local control rate of 44.4% with a 3-year minimum follow-up was obtained. Currently 33% are alive without evidence of disease 3 to 10 years following treatment. The most important prognostic indicator of outcome was size of vaginal recurrence. Of seven evaluable patients with tumors smaller than 2 cm there was one local failure. In contrast there were eight local failures in ten patients treated for tumors larger than 2 cm. Close follow-up and prompt diagnosis will enhance the chance of cure in endometrial cancer patients who do have recurrences.
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy; D013997:Time Factors; D014594:Uterine Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D014625:Vaginal Neoplasms / Q000209:etiology* / Q000473:pathology / Q000532:radiotherapy