Gastrin in pituitary tumours.
Twelve of 87 pituitary adenomas from patients with acromegaly, Cushing's syndrome. Nelson's syndrome, hyperprolactinaemia and without symptoms of hormone hypersecretion contained gastrin in concentrations from 0.5 to 166 pmol/g. Only ACTH-producing tumours contained gastrin, which occurred in forms smaller than those present in the normal adenohypophysis. The results indicate that corticotropic tumours may synthesize gastrin in moderate amounts.
D000236:Adenoma / Q000032:analysis*; D002850:Chromatography, Gel; D005755:Gastrins / Q000032:analysis*; D006801:Humans; D008968:Molecular Conformation; D010903:Pituitary Gland, Anterior / Q000032:analysis; D010911:Pituitary Neoplasms / Q000032:analysis*; D011863:Radioimmunoassay
D005755:Gastrins