title: An industry wide mortality study of chemical workers occupationally exposed to benzene. II. Dose response analyses.
abstract: The data presented in this paper show statistically significant dose response relations between cumulative exposure to benzene (ppm-months) and mortality from both all lymphopoietic cancer combined and leukaemia. Chemical workers with a cumulative exposure to benzene of at least 720 ppm-months experienced a relative risk of 3.93 for lymphatic and haematopoietic cancer when compared with workers with no occupational exposure. The dose response relation between cumulative exposure and non-Hodgkin's lymphopoietic cancer was of borderline statistical significance (p = 0.06). No dose response relation was detected for any other causes of death.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001554:Benzene / Q000009:adverse effects*; D002617:Chemical Industry; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007938:Leukemia / Q000139:chemically induced / Q000401:mortality; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000401:mortality*; D013997:Time Factors; D014481:United States
chemical_list: D001554:Benzene