A fast algorithm for the computation of the plasma concentration time curve and confidence limits in linear pharmacokinetics.
An algorithm is developed for the computation of the plasma concentration time curve for a drug administration regime involving fast injection (bolus) and/or continuous infusion. The effect of the pharmacokinetic model parameter variations on the plasma concentration time curve is analyzed and efficient algorithms for the computation of the parameter-induced first-order variation and confidence bounds of the plasma concentration time curve are also presented. The application of the method is illustrated with pharmacokinetic data for the etomidate.
D000465:Algorithms; D007700:Kinetics; D008432:Mathematical Computing; D004364:Pharmaceutical Preparations / Q000097:blood*
D004364:Pharmaceutical Preparations