title: Influence of minor plant constituents on porcine hepatic lipid metabolism. Impact on serum lipids.
abstract: The effects of plant constituents on lipid metabolism were examined in swine that had been fed for 4 weeks a standard diet containing, in addition, (per kg diet) 3.15 g of the methanol serial solvent fraction garlic bulbs or 3.5 g of the petroleum ether solubles high-protein barley flour or 5 mg of the plant growth regulator, AMO 1618. All treatments suppressed 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and cholesterol 7 alpha-hydroxylase activities. Modest increases in serum triglycerides were associated with significantly increased hepatic lipogenic activities in response to all treatments except that of the barley extract. The methanol solubles of a second lot of garlic were fractionated by HPLC and tested in an avian hepatocyte system. One component, an isoprenoid metabolite, MW 358, suppressed HMG-CoA reductase.
mesh_terms: D000821:Animal Feed; D000818:Animals; D002523:Edible Grain; D005737:Garlic; D001467:Hordeum; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010940:Plant Proteins / Q000494:pharmacology; D010946:Plants, Medicinal; D013552:Swine / Q000378:metabolism*
chemical_list: D008055:Lipids; D010940:Plant Proteins