Therapeutic efficacy of superactive charcoal in rats exposed to oral lethal doses of T-2 toxin.
Superactive charcoal, a compound known to complex with many toxins, was evaluated in this study for its effectiveness in preventing death in rats given an oral lethal dose of 8 mg/kg body weight of T-2 toxin. The median effective dose of oral superactive charcoal in preventing deaths in rats was 0.175 g/kg body weight. Concurrent use of cathartics, such as sorbitol, magnesium sulfate and sodium sulfate, to facilitate removal of the superactive charcoal:T-2 toxin complex formed in vivo did not enhance the survival rates of rats. One gram per kilogram body weight oral superactive charcoal enhanced survival times and survival rates in rats given 8 mg/kg of T-2 toxin as late as 3 hr after the T-2 toxin was administered. Some benefit in survival rate may be derived from giving the superactive charcoal as late as 5 hr after the T-2 toxin.
D000284:Administration, Oral; D000818:Animals; D002400:Cathartics / Q000627:therapeutic use*; D002606:Charcoal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D009145:Mushroom Poisoning / Q000188:drug therapy*; D051381:Rats; D012717:Sesquiterpenes / Q000037:antagonists & inhibitors*; D013605:T-2 Toxin / Q000037:antagonists & inhibitors*
D002400:Cathartics; D012717:Sesquiterpenes; D002606:Charcoal; D013605:T-2 Toxin