[Changes in amoxicillin pharmacokinetics in white rats with experimentally damaged kidneys and liver].
The blood level and the basic pharmacokinetic parameters (kel, Cop, T 1/2, AUC) of amoxicillin trihydrate were studied following its oral application to albino rats with experimentally injured kidneys (potassium chromate) and liver (tetrachloromethane). It was found that the impairment of these organs changed the extent of absorption, distribution, and excretion of the antibiotic.
D000658:Amoxicillin / Q000378:metabolism*; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D002840:Chromates / Q000633:toxicity; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D017680:Potassium Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002840:Chromates; D017680:Potassium Compounds; C027373:potassium chromate(VI); D000658:Amoxicillin; D002251:Carbon Tetrachloride
Promeni vŭv farmakokinetikata na amoksitsilina pri beli plŭkhove s eksperimentalno uvredeni bŭbretsi i cheren drob.