title: [Role of serum pepsinogen I values in primary duodenal ulcer in childhood].
abstract: Serum pepsinogen I (PGI) was measured by radioimmunoassay in the fasting state in three homogeneous family groups composed of parents and their children. Group 1, families, did not suffer from primary duodenal ulcer (PDU). Group 2, 10 families had at least one parent with PDU diagnosed endoscopically. Group 3, 6 families, had at least one child with PDU and one parent with PDU diagnosed endoscopically. The analysis of variance (ANOVA) of PGI in the examined children, showed a significant difference between the three groups (F = 22.83; p = 0.005). In all 3 groups the ANOVA of serum PGI of the fathers and the mothers were significantly different: fathers (F = 4.4; p = 0.241); mothers (F = 3.4; p = 0.05). A correlation was noted between PGI of the fathers and PGI of the children (r = 0.31; p = 0.05); but a more significant correlation was observed between PGI of the mothers and PGI of the children (r = 0.48; p = 0.001). In group 3, the correlation between PGI of the mothers and PGI of the children was striking (r = 0.89; p = 0.025). However, the PGI of the fathers and the PGI of the children were not different in this group (r = 0.27; p = n.s.). The multiple correlation between PGI of the children and PGI of both parents was significant (r2 = 0.316). In group 3, the correlation was very high between the mothers and the children (r2 = 0.81).
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002648:Child; D004381:Duodenal Ulcer / Q000097:blood* / Q000235:genetics; D005220:Fathers; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009035:Mothers; D020116:Pepsinogen A; D010435:Pepsinogens / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012306:Risk
chemical_list: D010435:Pepsinogens; D010446:Peptide Fragments; C037980:pepsinogen (1-12); D020116:Pepsinogen A
vernacular_title: Il ruolo dei valori sierici di pepsinogeno I nell'ulcera duodenale primaria in età pediatrica.