In vitro evaluation of the new paulomycin antibiotic paldimycin.
The comparative in vitro activity of paldimycin, a new antibiotic, was evaluated against 215 gram-positive bacteria. Activity of the compound was greater in nutrient agar of pH 6.8 than in Mueller-Hinton agar. All strains of staphylococci, streptococci, enterococci and Listeria monocytogenes were inhibited at concentrations less than or equal to 2 micrograms/ml. Activity of the new drug was generally comparable to that of vancomycin.
D000111:Acetylcysteine / Q000031:analogs & derivatives; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003470:Culture Media; D004187:Disaccharides; D006020:Glycopeptides / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003470:Culture Media; D004187:Disaccharides; D006020:Glycopeptides; C050461:paldimycin; D000111:Acetylcysteine