Ontogeny of the bovine neurohypophysial hormone precursors. III. Identification of neurohormones, neurophysins and copeptin in the early bovine fetus.
Neurohypophysial hormone precursors are small proteins processed into several fragments during axonal transport from hypothalamus to neurohypophysis. From 3-month-old fetal bovine pituitaries the three fragments of vasopressin precursor, arginine vasopressin, MSEL-neurophysin and copeptin, and the two fragments of oxytocin precursor, oxytocin and VLDV-neurophysin, have been isolated and characterized. These polypeptides are identical to those previously identified in the late fetus (7-9 months old) and in the adult. It is concluded that the same genes are expressed during fetal and adult lives, the vasopressin gene appearing roughly four times more active than the oxytocin gene in the early fetus. Vasotocin, mesotocin and additional neurophysin have not been detected in the early fetus.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001127:Arginine Vasopressin / Q000032:analysis; D002417:Cattle; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005333:Fetus; D006020:Glycopeptides / Q000032:analysis*; D009481:Neurophysins / Q000032:analysis*; D010121:Oxytocin / Q000032:analysis; D010446:Peptide Fragments / Q000032:analysis; D010903:Pituitary Gland, Anterior / Q000196:embryology*; D010908:Pituitary Hormones, Anterior / Q000032:analysis*; D011498:Protein Precursors / Q000032:analysis*
D000596:Amino Acids; D006020:Glycopeptides; D009481:Neurophysins; D010446:Peptide Fragments; D010908:Pituitary Hormones, Anterior; D011498:Protein Precursors; C048197:copeptins; D001127:Arginine Vasopressin; D010121:Oxytocin