title: Technetium-1,2-dihydroxy-1,2-bis(dihydroxyphosphinyl)ethane (99mTc-DHPE). A promising new skeletal imaging agent.
abstract: 99mTc-sodium pertechnetate was reduced and complexed with 1,2-dihydroxy-1,2-bis(dihydroxyphosphinyl)ethane (DHPE) with a yield higher than 95%. When administered to rats, 99mTc-DHPE demonstrated very good skeletal uptake, a high clearance from blood to the bones a low concentration in muscles and other organs, satisfactory biological stability and a clearance mainly through the kidneys. The biodistribution of 99mTc-DHPE in rats compared to that of 99mTc-methylenediphosphonate (99mTc-MDP) at 2 and 24 h post injection, showed higher skeletal uptake, substantially higher blood clearance, but also higher concentration in muscles which, however, caused no significant degradation in image quality. These characteristics suggest that 99mTc-DHPE is a promising new skeletal imaging agent.
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000000981:diagnostic imaging*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D004164:Diphosphonates; D005260:Female; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D011829:Radiation Dosage; D011854:Radiochemistry; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium; D013669:Technetium Tc 99m Medronate
chemical_list: D004164:Diphosphonates; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; C048432:technetium Tc 99m 1,2-diphosphonoethylene glycol; D013667:Technetium; D013669:Technetium Tc 99m Medronate