[Extraction and determination of prednisolone in drugs and excipients in ointments and creams and the uniformity of distribution in prednisolone ointment].
For the purpose of measuring the contents of prednisolone in low concentrated ointments and creams an instruction was elaborated that includes several steps of extraction, in the resulting solution of which the assay of the steroid by Blue Tetrazolium reaction will be done. The procedure permits the determination of prednisolone in presence of most of usual ingredients of ointment bases except wool alcohols. Also no influence is given by some remedies combined with prednisolone for topical application except coal tar solution. The results confirm a correct reflection of the steroid contents declared respectively the recovery of the steroid added to various ointment bases. Introducing discussion to content uniformity concerning low concentrated ointments is made, and some deviations are shown.
D004339:Drug Compounding; D004356:Drug Storage; D004655:Emulsions; D005079:Excipients; D009823:Ointment Bases; D009824:Ointments; D011239:Prednisolone / Q000032:analysis*
D004655:Emulsions; D005079:Excipients; D009823:Ointment Bases; D009824:Ointments; D011239:Prednisolone
Beitrag zur Extraktion und Bestimmung von Prednisolon neben Arznei- und Hilfsstoffen aus L/W- und W/L-Grundlagen sowie zur Gehaltsgleichförmigkeit bei Prednisolon-Salben.