[The study of cell surface antigens in bladder tumors: ABH-isoantigen and Thomsen-Friedenreich antigen].
ABH isoantigen (ABH-ag) and Thomsen-Friedenreich antigen (T-ag) was investigated by the Avidin-Biotin peroxidase Complex (ABC) method in 85 bladder tumors. Furthermore mapping of epitheliums and related expression of ABH-ag and T-ag was studied in 34 bladders surgically removed for cancer. There was a correlation between histological grade, stage and deletion of the antigenicity (ABH-ag and T-ag). The recurrence rate after surgery of the cases with the normal antigenicity (ABH-ag and T-ag) was significantly lower than that of the cases with the abnormal antigenicity. The 5-year survival rates of the cases with the normal antigenicity (ABH-ag and T-ag) was relatively higher than that of the cases with the abnormal antigenicity. Combination of two markers (ABH-ag and T-ag) was significantly more effective than the single marker. The deletion of the antigenicity (ABH-ag and T-ag) was related to the intramural lym hatic invasion, the intramural venous invasion and the intramural histological mode of spread in mapping of 34 bladder tumors. Fourteen cases of 34 mapped bladders had the abnormal ABH-antigenicities in the bladder tumors and the normal ABH-antigenicities in the other epitheliums. Eleven cases of 34 mapped bladders had the abnormal T-antigenicities in the bladder tumors and the normal T-antigenicities in the other epitheliums. The cases that expressed the abnormal antigenicities of the tumors with the normal antigenicities of the other epitheliums had good clinical course after operation. There was no relation between the abnormal epitheliums (dysplasia, hyperplasia and Brunn's nest) and the antigenicity. Therefore the study of expression of ABH-ag and T-ag in bladder epitheliums may be valuable for predicting the malignant potential in bladder tumors.
D000017:ABO Blood-Group System / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate; D004187:Disaccharides / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000401:mortality / Q000601:surgery
D000017:ABO Blood-Group System; D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D004187:Disaccharides; C016467:Thomsen-Friedenreich antigen