In vivo interaction of spironolactone and phenobarbital with cholesterol; effect on cholesterol organ concentration.
In this work, the effect of pretreatment with spironolactone or phenobarbital on female Wistar rats after a chronic administration of cholesterol, upon the cholesterol concentration in blood, brain and liver was examined. It was found that the pretreatment reduced cholesterol in all tissues in the order, brain - plasma - liver. The findings were attributed to an increased biodegradation and disposition of cholesterol. It could also be concluded that after the pretreatment we may have a predominance of the catabolic and/or the disposition rather than of the synthetic and/or absorption processes for the steroid.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013148:Spironolactone / Q000494:pharmacology*
D013148:Spironolactone; D002784:Cholesterol; D010634:Phenobarbital