Combined immunostimulation (Propionibacterium avidum KP 40) and anticoagulation (heparin) prevents metastatic lung and liver colonization in mice.
The antineoplastic activity of Propionibacterium avidum KP-40 and its enhancement by anticoagulation with heparin was studied. In Balb/c mice syngeneic sarcoma L-1 exclusively caused tumor colonization of the lungs. After neuraminidase treatment the organotropism of this tumor was changed, with tumor nodules developing in lung and liver. After single systemic application of Propionibacterium avidum KP-40 the number of lung and liver colonies decreased evidently. Combination of this immunomodulating therapy with temporary anticoagulation resulted in further reduction of tumor colonies in lung and liver.
D000276:Adjuvants, Immunologic; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology; D008113:Liver Neoplasms / Q000517:prevention & control / Q000556:secondary; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009362:Neoplasm Metastasis / Q000276:immunology* / Q000473:pathology; D011424:Propionibacterium / Q000276:immunology*; D012513:Sarcoma, Experimental / Q000097:blood / Q000276:immunology / Q000473:pathology
D000276:Adjuvants, Immunologic; D006493:Heparin