Short and long term effects of ethanol on glycerolipid synthesis from palmitate in fasted rat hepatocytes.
Prolonged ethanol administration to rats increased the rates of glycerolipid synthesis from added [U-14C]palmitate in fasted hepatocytes; this increase was more than 2-fold in triglyceride synthesis. Prolonged ethanol administration to rats completely eliminated the acute ethanol-induced increase in triglyceride synthesis from palmitate in hepatocytes from fasted rats. This adaptive change occurred in a short initial period of about 10 days of ethanol feeding. In hepatocytes from fasted control rats, addition of ethanol produced a rapid and strong increase in the concentration of glycerol 3-phosphate. By contrast, this acute effect of ethanol disappeared in hepatocytes from fasted alcoholic rats after a prolonged--5 weeks--administration of ethanol in a liquid diet.
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D005989:Glycerides / Q000096:biosynthesis*; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism*; D010743:Phospholipids / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000096:biosynthesis
D005989:Glycerides; D010169:Palmitic Acids; D010743:Phospholipids; D014280:Triglycerides; D019308:Palmitic Acid; D000431:Ethanol