Do angiotensin-induced changes in sheep renal venous blood and plasma composition indicate a reversal of glomerular filtration?
Angiotensin II markedly lowers the relative cell content of renal venous blood both with injection into the jugular vein and into the left ventricle of anaesthetised sheep; angiotensin I has a similar effect in this regard when given intravenously but the decreased cellular fraction is much less evident with left ventricular injection when the direct presentation to the kidneys precludes prior intra-pulmonary conversion to angiotensin II. The angiotensins also produce readily demonstrable alterations in renal venous plasma electrolyte, protein, creatinine and urea levels. This pattern of changes is related to associated intra-renal haemodynamics, reverse filtration of proximal tubular fluid, a possible anti-diuretic action of angiotensin I itself on the peritubular capillaries and acute renal failure in man and experimental animals.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001769:Blood / Q000187:drug effects*; D001773:Blood Cells / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D004573:Electrolytes / Q000097:blood; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000502:physiology; D012079:Renal Circulation / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects; D012756:Sheep; D014508:Urea / Q000097:blood
D001798:Blood Proteins; D004573:Electrolytes; D000804:Angiotensin II; D014508:Urea; D003404:Creatinine