Pyrroxamycin, a new antibiotic taxonomy, fermentation, isolation, structure determination and biological properties.
A strain of streptomycete was found to produce a new antibiotic pyrroxamycin. This compound was isolated from the culture broth of Streptomyces sp. S46506. The chemical structure was determined to be 4,5-dichloro-2-(6',8'-dichloro-4'H-1',3'-benzodioxin-4'-yl)-3-nitr opyrrole by its chemical character and 1H and 13C NMR spectral analysis. Pyrroxamycin was active against Gram-positive bacteria and dermatophytes.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D011758:Pyrroles / Q000302:isolation & purification / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000032:analysis
D000900:Anti-Bacterial Agents; D011758:Pyrroles; C053531:pyrroxamycin