Effect of L-acetyl carnitine HCl on rat steady-state visual evoked potentials. Comparison with L-carnitine.
L-acetyl carnitine administration increases the amplitude of the steady-state visual evoked potentials (VEPs) obtained with sinusoidal luminance stimulation at 8.4 Hz. This effect was studied with three different doses of L-acetyl carnitine (50, 25, 5 mg/kg) and was compared with the results of injection of similar doses of L-carnitine. The effect is most evident when 50 mg/kg L-acetyl carnitine are administered and has two different time peaks. The second peak of activity showed a dose dependency when 25 mg/kg and 5 mg/kg doses were tested. The effects of L-acetyl carnitine could be depressed by the simultaneous administration of atropine sulfate.
D000108:Acetylcarnitine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002331:Carnitine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D008297:Male; D010775:Photic Stimulation; D051381:Rats; D011919:Rats, Inbred Strains
D000108:Acetylcarnitine; D001285:Atropine; D002331:Carnitine