Comparison of the urate lowering effects of allopurinol and diflunisal.
The urate lowering effect of diflunisal, a fluorinated salicylate with an antiinflammatory action, was compared with that of allopurinol in a crossover study. When patients took diflunisal the mean serum urate was significantly greater than on allopurinol but still was within the optimal range in 6 of 8 patients studied. This effect was consistent with its uricosuric action. No inhibition of xanthine oxidase activity by diflunisal was found. Diflunisal could be particularly useful in patients who require a drug with both a uricosuric and an antiinflammatory effect.
D000493:Allopurinol / Q000627:therapeutic use*; D004061:Diflunisal / Q000627:therapeutic use*; D006073:Gout / Q000097:blood / Q000188:drug therapy; D006801:Humans; D009994:Osmolar Concentration; D012459:Salicylates / Q000627:therapeutic use*; D014527:Uric Acid / Q000097:blood*; D019820:Xanthine; D014970:Xanthines / Q000097:blood
D012459:Salicylates; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D000493:Allopurinol; D004061:Diflunisal