Canine lymphoma-associated antigens defined by murine monoclonal antibodies.
Lymphoma in dogs resembles human non-Hodgkin's lymphoma in pathological presentation, immunophenotype, and response to therapy, thus representing a good model for comparative studies with human disease. Monoclonal antibodies (MAbs) were derived from mice immunized with a dog lymphoma cell line. Three MAbs were selected for further application in immunophenotyping and immunotherapy. The binding specificities, antigen characterization, and isotypes for these MAbs are described.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000912:Antibodies, Neoplasm / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D002051:Burkitt Lymphoma / Q000276:immunology; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D005434:Flow Cytometry; D006017:Glycolipids / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008223:Lymphoma / Q000276:immunology / Q000662:veterinary*; D008970:Molecular Weight
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D006017:Glycolipids