Cardiovascular effects of mycotoxin T-2 after topical application in rats.
Evidence has been mounting that trichothecenes cause cardiac lesions and cardiovascular effects in general. T-2 toxin, dissolved in dimethyl sulfoxide, was applied in doses of 0, 1.0, 2.0 mg/kg to the skin of Sprague-Dawley rats. Twenty-four hours later, the cardiac function of the animals was assessed, followed by killing and histological examination. It was found that the arterial blood pressure values were lower in the 2.0 mg/kg group, the peak intraventricular pressure was lower in both the 1.0 and 2.0 mg/kg groups, and the resting systolic and diastolic blood pressure values of the 2.0 mg/kg group were lower than the 0 and 1.0 mg/kg groups. The 1.0 and 2.0 mg/kg groups had significantly lower epinephrine-stimulated intraventricular pressure values, indicating reduced contractility. Extended Q-T intervals in electrocardiograms of the 1.0 and 2.0 mg/kg groups suggested also impaired contractility. The histological examination gave equivocal results. It is concluded that topical applications of small doses of T-2 toxin have a noticeable negative effect on cardiovascular function.
D000279:Administration, Cutaneous; D000818:Animals; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009205:Myocarditis / Q000139:chemically induced; D051381:Rats; D012717:Sesquiterpenes / Q000008:administration & dosage*; D013605:T-2 Toxin / Q000008:administration & dosage*
D012717:Sesquiterpenes; D013605:T-2 Toxin