Effects of acute nicotine and ethanol on medial prefrontal cortex self-stimulation in rats.
The acute effects of nicotine and ethanol were studied in low and high rates of intracranial self-stimulation (ICSS) of the medial prefrontal cortex (MPFC) in the rat. Nicotine tended to increase low ICSS rates but did not change or even reduced high ICSS rates. Independent of ICSS rate, ethanol tended to decrease ICSS, but only at high doses (1.0 g/kg). It is suggested that the effects of nicotine and ethanol on ICSS may be mediated by their effects on dopamine.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D005625:Frontal Lobe / Q000502:physiology*; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation / Q000187:drug effects*
D000431:Ethanol; D009538:Nicotine