Diethylsuccinate carboxylesterase activity in sheep poisoned by copper.
Plasma diethylsuccinate carboxylesterase activity in plasma was elevated within 7 days in 4 sheep which received 4 mg Cu per kg body weight in gelatin capsules daily for 100 days followed by the same amount of Cu as a drench until the haemolytic crisis commenced. Plasma aspartate amino-transferase and sorbitol dehydrogenase activities in plasma were not elevated in these animals until sixty days after the Cu treatment began. Activities of all 3 enzymes in the liver homogenates from copper-treated sheep were lower (P less than 0.01) than in control animals.
D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D003300:Copper / Q000506:poisoning*; D005260:Female; D007700:Kinetics; D012756:Sheep; D012757:Sheep Diseases
D003300:Copper; D002265:Carboxylic Ester Hydrolases; C053307:diethyl succinate carboxylesterase