Seminal fluid antisperm antibodies do not reflect those present on the sperm surface.
Given the increasing evidence that head-directed antibodies can impair fertilization in vitro, as well as play a role in the impaired entry of sperm into cervical mucus, our findings provide strong support for the direct analysis of immunoglobulins bound to the sperm surface, rather than by indirect analysis through the study of seminal fluid.
D000328:Adult; D000954:Antigens, Surface / Q000032:analysis* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D006801:Humans; D007248:Infertility, Male / Q000276:immunology; D008297:Male; D012661:Semen / Q000276:immunology*; D013094:Spermatozoa / Q000276:immunology*
D000954:Antigens, Surface; D001323:Autoantibodies