title: Port-wine stains: a new hypothesis.
abstract: Port-wine stains have been shown to be derived from a progressive ectasia of the superficial vascular plexus. Recent studies have documented a marked decrease in nerves associated with these abnormal vessels. It is suggested that this nerve loss is primarily of autonomic origin (sympathetic) and the failure to regulate blood flow is the basis for the progressive vascular ectasia that characterizes these lesions.
mesh_terms: D000320:Adrenergic Fibers / Q000503:physiopathology; D001808:Blood Vessels / Q000294:innervation / Q000503:physiopathology; D006391:Hemangioma / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D012867:Skin / Q000098:blood supply / Q000503:physiopathology; D012878:Skin Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D013566:Sympathomimetics / Q000627:therapeutic use; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D013566:Sympathomimetics