Proposal for treatment of cancer micrometastases, in particular of breast cancer.
The proposal deals with: stage I of breast cancer following mastectomy, and stage II up to T2a, N1a, MO following mastectomy with exenteration of the axilla. The mammary glands can be safely surgically removed whole without any unacceptably serious effect on the rest of the organism (naturally apart from the mental trauma, post-operation stress and the accompanying transitory drop in immunological function). The treatment proposed here consists of the timely and strict sequence of several procedures: I. The patient, following a bilateral mastectomy, is immunized intradermally with a homogenate of dissection tissue from an allogeneic breast with Freund's adjuvant in order to achieve active specific sensitization of the lymphocytes and macrophages. II. The patient is given adoptive transfusions of blood obtained from male donors, who are previously immunized by homogenate from allogeneic breast tissue (but not from the patient's own breast). After achieving lymphocyte sensitization in all donors, blood transfusions are administered to the patient, one by one in a precise time sequence. III. The patient receives final immunological treatment in the form of indirect immunocytotoxicity and also of crossed organospecific reactivity with the serum of any suitable male bird previously immunized with homogenate from the mammary gland of the right mammal. IV. The procedure is terminated with pyrotherapy. V. Continuous non-specific auxiliary somatic and psychological treatments.
D001803:Blood Transfusion; D001943:Breast Neoplasms / Q000276:immunology / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D007114:Immunization; D007165:Immunosuppression Therapy; D007167:Immunotherapy; D008297:Male; D009362:Neoplasm Metastasis