Biological studies on indole derivatives. I. Synthesis and pharmacological studies of 2-oxo-3-indolyl derivatives.
Two compounds, 3-hydroxy-3-acetonyl-oxindole (I) and compound 3-acetonylidene-oxindole (II) were synthesized by a convenient method, and their pharmacological/toxicological effects were studied in rabbit. These compounds produced transitory effects on serum enzymes. The cholesterol mobilizing effect is more prominent with compound (I).
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D000078183:Oxindoles; D011817:Rabbits
D001798:Blood Proteins; D006454:Hemoglobins; D007211:Indoles; D000078183:Oxindoles; C052856:3-hydroxy-3-acetonyl-2-oxindole; C052855:3-acetonylidene-2-oxindole; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase