[Immunological and morphological properties of in vitro transformed fibroblasts. III. Recognition by macrophages and activated lymphocytes of mouse and rat cells of various degrees of tumorigenicity].
Data are provided on the development of tumorigenicity in cells of 6 independently produced lines of mouse and rat embryonic fibroblasts during their prolonged passage in vitro. The data on the development of lysis of these cells by macrophages and activated lymphocytes during the same passage indicate that enhanced cell lysis of cells by natural effectors and, hence, cell recognition by them may be regarded as an obligatory manifestation of cell malignization.
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000276:immunology* / Q000473:pathology; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000276:immunology; D007157:Immunologic Surveillance; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains
Immunologicheskie i morfologicheskie svoĭstva fibroblastov, transformirovannykh in vitro. III. Raspoznavanie makrofagami i aktivirovannymi limfotsitami myshinykh i krysinykh kletok raznoĭ stepeni opukholerodnosti.