title: [Occurrence of the alcoholic tolerance phenomenon and its relation to the daily frequency of ethanol doses and with the presence of a withdrawal interval, in an experimental model of alcoholism in rats].
abstract: In this paper we present the effects of the number of daily toxic doses of alcohol and of the duration of withdrawal period on alcohol tolerance in rats submitted to cycles of 21 doses each. It was observed that alcohol tolerance was increased in animals which received less number of alcohol doses by day and that some degree of tolerance can be detected even after a withdrawal interval of 15 days.
mesh_terms: D000435:Alcoholic Intoxication; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D000431:Ethanol / Q000008:administration & dosage* / Q000378:metabolism; D007408:Intestinal Absorption; D007441:Intubation, Gastrointestinal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome
chemical_list: D000431:Ethanol
vernacular_title: Ocorrência do fenômeno de tolerância alcoólica e suas relações com a freqüência diária das doses de etanol e com a presença de um intervalo de abstinência, em um modelo experimental de alcoolismo em ratos.