Evaluation of the anti-inflammatory drug indomethacin, for its genotoxicity in mice.
Indomethacin, a non-steroidal anti-inflammatory drug was assessed for its genotoxicity in Swiss male mice employing bone marrow micronucleus induction, abnormal sperm formation and the induction of meiotic chromosome anomalies in spermatocytes as the test parameters. The results showed that the test compound was toxic to the genetic material in the dose range of 12-36 mg/kg body weight.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology*; D002273:Carcinogens; D002467:Cell Nucleus / Q000187:drug effects; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D007213:Indomethacin / Q000633:toxicity*; D008297:Male; D051379:Mice; D009153:Mutagens; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects*
D002273:Carcinogens; D009153:Mutagens; D007213:Indomethacin