title: [Therapeutic possibilities of using phosphocreatine in complicated myocardial infarct].
abstract: A total of 40 patients with complicated myocardial infarction (MI), with life threatening arrhythmias and congestive heart failure. II-IV degree after Walk's classification, with a concomitant pathology were investigated. Phosphocreatine (PC) therapy (i. v. infusions for 3 days at a total dose of 144 g) made a positive effect on a course of disease. A degree of clinical symptoms of heart failure lessened in 26 patients, disturbed cardiac rhythm got stable in 23 patients. A PC positively inotropic effect was observed. The comparison of the results of PC therapy with those of 173 MI patients on routine therapy showed heart contractility preserved at a higher level and the improvement of gas exchange. A conclusion was made of a favorable effect of the drug on a course of complicated MI.
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology; D004341:Drug Evaluation; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy*; D010725:Phosphocreatine / Q000627:therapeutic use*; D012306:Risk; D013997:Time Factors
chemical_list: D010725:Phosphocreatine
vernacular_title: Terapevticheskie vozmozhnosti primeneniia fosfokreatina pri oslozhnennom infarkte miokarda.