Kinetics and mechanism of the hydrolysis of a 2-substituted imidazoline, cibenzoline (cifenline).
The results of a kinetic and mechanistic study of the hydrolysis of a new antiarrhythmic agent, cibenzoline, are reported. The reaction is subject to specific base catalysis which proceeds via the protonated cibenzolinium ion. No evidence for the existence of a "pseudobase"-type intermediate could be found. The results support only one of two different mechanisms which have been proposed previously for the hydrolysis of this class of compounds.
D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007093:Imidazoles / Q000378:metabolism*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D011199:Potentiometry; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
D007093:Imidazoles; C032151:cifenline