Effect of light deprivation upon the morphology of axon terminals in the dorsal lateral geniculate nucleus of mouse: an electron microscopical study using serial sections.
Two populations of morphologically different large axon terminals have been observed electron microscopically in the dorsal lateral geniculate nucleus of mice raised in complete darkness from birth up to 19 days of age. One population includes larger terminals indistinguishable from the large terminals present in control animals, i.e. they have round synaptic vesicles, rather pale mitochondria, membrane saculae, coated vesicles, and asymmetric contacts with encrusted dendritic spines of portions of dendrites of geniculo-cortical relay neurons. The other population includes large terminals which also have asymmetric contacts with encrusted dendritic spines or portions of dendrites of geniculo-cortical relay neurons, but they show darker mitochondria, absence of both membrane saculae and coated vesicles, and significantly higher synaptic vesicle density and smaller size than the large control ones. We suggest that the latter population of terminals could be inactive due to the absence of visual input.
D000818:Animals; D001369:Axons / Q000502:physiology / Q000648:ultrastructure*; D003624:Darkness; D005829:Geniculate Bodies / Q000502:physiology / Q000648:ultrastructure*; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D009474:Neurons / Q000145:classification / Q000648:ultrastructure; D012683:Sensory Deprivation; D013572:Synaptic Vesicles / Q000648:ultrastructure; D013997:Time Factors