Cultured skin fibroblasts in schizophrenia: acute growth and susceptibility to damage.
The study of cultured fibroblasts derived from skin biopsies of patients with inherited neurodegenerative disorders has aided in the elucidation of their pathological basis. This usefulness might be expected to extend to the study of fibroblast characteristics in schizophrenia in view of recent evidence of neurodegenerative changes in the disorder. In this study, the acute growth characteristics and response to toxic oxygen metabolites of fibroblast cell lines derived from skin biopsies of patients with schizophrenia (n = 9) are compared with those derived from psychiatric patients with various diagnoses not associated with a deteriorating course (controls = 11). No significant differences between the cell lines of the two patient groups are found.
D000328:Adult; D001706:Biopsy; D001925:Brain Damage, Chronic / Q000473:pathology; D002455:Cell Division; D002460:Cell Line; D002470:Cell Survival; D004249:DNA Damage; D005260:Female; D005347:Fibroblasts / Q000473:pathology*; D005609:Free Radicals; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000473:pathology*; D012867:Skin / Q000473:pathology
D005609:Free Radicals