[Inhibiting effect of (sarcosine-1-isoleucine-8)-angiotensin II in anesthesized rats].
The peptidic sequence (Sarcosine-1-Isoleucine-8)-Angiotensin II has been demonstrated to be an in vitro specific and competitive antagonist of the Angiotensin II action. The present results show it to be a competitive antagonist also in vivo since pA2 values are similar, always reaches a 100% response on increasing the Angiotensin II dose, and when relating log (DR-1) and log dose of agonist, the slope is very near to one (0.925).
D000758:Anesthesia; D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D001667:Binding, Competitive; D001794:Blood Pressure / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000804:Angiotensin II; C032651:angiotensin II, Sar(1)-Ile(5)-
Acción inhibidora de la (sarcosina-1-isoleucina-8)-angiotensina II en rata anestesiada.