Differences between muscular receptors and neural receptors for cholecystokinin-octapeptide in the guinea-pig gallbladder.
To investigate the differences between muscular and neural receptors for cholecystokinin-octapeptide (CCK-OP) in the guinea-pig gallbladder, we studied the effects of dibutyryl cyclic GMP (dbc GMP) on CCK-OP-evoked contraction and [3H]acetylcholine (ACh) release. 10(-3) M dbc GMP significantly reduced CCK-OP (10(-8) M)-evoked contractions without affecting the peptide-induced [3H]ACh release. It is suggested that there are two types of CCK-OP receptors in the guinea-pig gallbladder (dbc GMP-sensitive muscular receptors and dbc GMP-insensitive neural receptors).
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D003995:Dibutyryl Cyclic GMP / Q000494:pharmacology; D005260:Female; D005704:Gallbladder / Q000187:drug effects* / Q000294:innervation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011949:Receptors, Cholecystokinin / Q000502:physiology*; D012844:Sincalide / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D011949:Receptors, Cholecystokinin; D003995:Dibutyryl Cyclic GMP; D012844:Sincalide; D000109:Acetylcholine