Kaluresis independent K homeostasis in dogs: activity after ureter ligation and pancreatectomy.
In ureter ligated dogs intravenous administration of KCl stimulates both insulin secretion and activity of a kaluresis independent K homeostatic mechanism (K transfer capacity) that retards the development of hyperkalemia by transferring K to intracellular fluid. If the preparation is K loaded by infusion with 2 mEq KCl/kg/hr until prelethal ECG changes of hyperkalemic cardiotoxicity appear, about 50% of administered K is transferred. An increased proportion--70%--is transferred if the animal is K loaded 70 minutes after pancreatectomy--when serum immunoreactive insulin is fixed at less than 4 uU/ml. That proportion (70%) is unchanged by simultaneous adrenalectomy, but is reduced to less than 40% by propranolol blockade of B receptors. Increased post pancreatectomy K transfer capacity apparently involves K transfer mediated by B receptors that are activated by an extra-adrenomedullary B agonist(s). Findings also indicate that residual post pancreatectomy insulin biological activity mediates K transfer.
D000818:Animals; D001693:Biological Transport, Active; D004285:Dogs; D005260:Female; D006706:Homeostasis; D008297:Male; D010179:Pancreas / Q000502:physiology*; D010180:Pancreatectomy; D011188:Potassium / Q000378:metabolism*; D014513:Ureter / Q000502:physiology*
D011188:Potassium