title: Penetration of norfloxacin into human prostatic tissue following single-dose oral administration.
abstract: Concomitant concentrations of norfloxacin in serum, urine and prostatic tissue were determined in 12 patients following a single oral dose of 400 mg. Tissue levels ranged from 0.3 to 1.73 mg/kg, and therapeutic concentrations were demonstrable for as long as 8 h following dosage. The mean ratio of tissue to serum concentration was 1.01 +/- (SE) 0.13.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D009643:Norfloxacin / Q000378:metabolism* / Q000627:therapeutic use; D011467:Prostate / Q000378:metabolism*; D011472:Prostatitis / Q000188:drug therapy
chemical_list: D009643:Norfloxacin