Effect of peritoneal dialysis fluid and pH on bactericidal activity of ciprofloxacin.
Ciprofloxacin is active in vitro against most bacteria that cause peritonitis associated with peritoneal dialysis. We compared the effects of pH (5.5 and 7.4) and medium (dialysis fluid) on the bactericidal activity of ciprofloxacin, tobramycin, vancomycin plus rifampin, and rifampin against Pseudomonas aeruginosa, Escherichia coli, and three strains of staphylococci. The bactericidal activity of ciprofloxacin was not significantly affected by pH or medium, in contrast to the activity of tobramycin, which was decreased by low pH.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001202:Ascitic Fluid / Q000032:analysis*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000209:etiology / Q000382:microbiology; D002939:Ciprofloxacin / Q000494:pharmacology*; D004357:Drug Synergism; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D010538:Peritonitis / Q000209:etiology / Q000382:microbiology; D012996:Solutions / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D012996:Solutions; D002939:Ciprofloxacin