Ultrastructural aspects of cynomolgus atherosclerotic carotid artery lesions on cholestyramine 'regression' treatment.
The carotid artery lesions of atherosclerotic cynomolgus monkeys treated with cholestyramine and studied with scanning electron microscopy appeared to be less bulging and largely covered by endothelial cells. With transmission electron microscopy these lesions showed an evident disappearance of cells and of extra- and intracellular lipid; a marked relative increase of fibrous material in the intercellular matrix, chiefly collagen and elastin fibers, was noted.
D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000473:pathology; D002339:Carotid Arteries / Q000648:ultrastructure*; D002792:Cholestyramine Resin / Q000494:pharmacology / Q000627:therapeutic use*; D003094:Collagen / Q000378:metabolism; D004036:Diet, Atherogenic; D004549:Elastin / Q000378:metabolism; D008251:Macaca / Q000502:physiology*; D008252:Macaca fascicularis / Q000502:physiology*; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D013997:Time Factors
D002792:Cholestyramine Resin; D003094:Collagen; D004549:Elastin