Effect of experimental shock conditions on the serum T4 level of rats and response of their thyroid gland to exogenous TSH.
150 min ligature of the superior (cranial) mesenteric artery (intestinal ischemia) significantly decreases serum T4 level and completely inhibits the response of the thyroid gland to exogenous TSH in rats. 300 min ligature of the hind limbs (tourniquet shock) decreases serum T4 level and the T4 response of thyroid gland to exogenous TSH in rats. The probable reasons for altered function of the thyroid gland in enteroendotoxemic shock conditions are discussed.
D000818:Animals; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D012769:Shock / Q000097:blood / Q000503:physiopathology*; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*; D013972:Thyrotropin / Q000494:pharmacology*; D013974:Thyroxine / Q000097:blood*
D013972:Thyrotropin; D013974:Thyroxine