Cyclosporine administration decreases liver vitamin A stores in normal and vitamin A-deficient rats.
Thirty-four Wistar rats were fed a marginal or normal vitamin A diet and received daily for 14 days an intragastric intubation of oil supplemented with 0, 20, or 60 mg X kg-1 of cyclosporine A. The hepatic content and concentration of vitamin A were significantly decreased by cyclosporine treatment, whereas no modification occurred in kidney or serum vitamin A levels. No induction of hepatic cytochrome P-450 was observed in treated animals. These results suggest that cyclosporine interferes with vitamin A stores; thus, vitamin A supplementation may be useful in patients receiving cyclosporine therapy. Drug-metabolizing enzymes, which are cytochrome P-450 dependent, did not seem to be involved in the hepatic vitamin A decrease observed.
D000818:Animals; D001361:Avitaminosis / Q000378:metabolism*; D003524:Cyclosporins / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D008099:Liver / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D014801:Vitamin A / Q000097:blood / Q000378:metabolism*
D003524:Cyclosporins; D014801:Vitamin A; D003577:Cytochrome P-450 Enzyme System