title: A comparison of ICRP Publication 30 lung model-based predictions with measured bioassay data for airborne natural UO2 exposure.
abstract: In this paper a comparison is made between the build-up of U thorax burdens and the predicted total lung (lung and lymph) burden, based on the lung model provided in ICRP Publication 30 for a group of 29 atomic radiation workers at a Canadian fuel fabrication facility. A similar comparison is made between the predicted ratio of the total lung burden to urinary excretion and the ratio obtained from bioassay data. The study period for the comparison is 5 y. The inhalation input for the lung model calculations was derived from air-sampling data and the choice of particle size activity median aerodynamic diameter (AMAD) was guided by particle size measurements made at representative work locations. The pulmonary clearance half-times studied were 100, 250 and 500 d. For the purpose of this comparison, averaged exposure and averaged bioassay data for the group were used. This comparison indicates that for the conditions of this facility, the assumption of a 500-d pulmonary clearance half-time and a particle size of 1 micron (AMAD) may be too conservative. It is suggested that measurements of air concentrations and particle size used as input parameters for the ICRP Publication 30 lung model may be used to calculate bioassay parameters which may then be tested against bioassay data obtained as part of an operational health physics program, thereby giving a useful step towards defining a derived air concentration value for U in the workplace.
mesh_terms: D000393:Air Pollutants / Q000032:analysis*; D000395:Air Pollutants, Occupational / Q000032:analysis*; D000396:Air Pollutants, Radioactive / Q000032:analysis*; D001681:Biological Assay; D001822:Body Burden; D002170:Canada; D006801:Humans; D008168:Lung / Q000032:analysis; D008196:Lymph / Q000032:analysis; D008954:Models, Biological; D010316:Particle Size; D013909:Thorax / Q000032:analysis*; D014501:Uranium / Q000032:analysis*; D017974:Uranium Compounds; D014556:Urine / Q000032:analysis
chemical_list: D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D000396:Air Pollutants, Radioactive; D017974:Uranium Compounds; D014501:Uranium; C047385:uranium oxide