Study of anti-Fya in five black Fy(a-b-) patients.
Fya antibodies were detected in 5 Fy(a-b-) black patients during a 5-year period. The Duffy phenotype was confirmed using anti-Fya, anti-Fyb, and anti-Fy3 by an adsorption-elution technique. These 5 patients had sickle cell disease and had received multiple blood transfusions. The antibodies were all found during the investigation of a hemolytic transfusion reaction or failure to achieve the desired red cell increments after transfusion.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000276:immunology*; D000906:Antibodies / Q000032:analysis*; D044383:Black People; D001789:Blood Group Antigens / Q000276:immunology*; D001803:Blood Transfusion; D004375:Duffy Blood-Group System / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012805:Sickle Cell Trait / Q000097:blood / Q000276:immunology* / Q000628:therapy
D000906:Antibodies; D001789:Blood Group Antigens; D004375:Duffy Blood-Group System