Severe acute thrombocytopenia following infusion of plasma containing anti P1A1.
An 18-year-old girl with a preoperative platelet count of 216,000/cmm received 3 units of stored plasma at the time of surgery. Within 6 hours her platelet count had fallen to 5,000/mm3 and hemorrhagic manifestations appeared. One of the plasma donors was found to be P1A1 negative with an anti P1A1 antibody. The recipient, who was P1A1 positive, recovered normal platelet counts by day 8 post plasma infusion.
D000293:Adolescent; D000906:Antibodies / Q000276:immunology*; D016824:Antigens, Human Platelet; D005260:Female; D006801:Humans; D039661:Integrin beta3; D007519:Isoantigens / Q000276:immunology*; D010976:Platelet Count; D013921:Thrombocytopenia / Q000209:etiology* / Q000276:immunology; D065227:Transfusion Reaction
D000906:Antibodies; D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007519:Isoantigens