title: Right ventricular tissue PO2 in dogs. Effects of hemodilution and acute right coronary artery occlusion.
abstract: Right ventricular (RV) epicardial tissue oxygen pressure (PtO2) was measured polarographically by means of a platinum multiwire surface electrode on the in situ beating heart of ten anesthetized dogs prior to and after moderate (Hct 28%) normovolemic hemodilution (HD) with dextran 60. In five dogs the effect of acute occlusion of the right coronary artery (RCA) on PtO2 was analyzed. The PtO2 histograms at baseline revealed a bell-shaped configuration and a mean PtO2 of 46.2 +/- 7.1 mm Hg which coincides with the PtO2 on the left ventricle (LV) reported by others. After HD mean PtO2 increased to 51.4 +/- 8.5 mm Hg (P = 0.02) without alterations of the histogram's configuration. Hemodynamics and blood gas analyses were unchanged after HD. RCA ligature was followed by non-uniform changes in the PtO2 pattern. Thus, despite marked differences in external work and O2 consumption, the PtO2 in both RV and LV myocardium are similar at rest. The increase of PtO2 in the RV at reduced Hct values, which is not seen in the LV myocardium, can be related to differences in functional capillary density between both ventricles.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D003251:Constriction, Pathologic; D003331:Coronary Vessels / Q000502:physiology*; D004285:Dogs; D005260:Female; D006339:Heart Rate; D006352:Heart Ventricles / Q000378:metabolism; D006438:Hemodilution; D008026:Ligation; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D011048:Polarography; D013318:Stroke Volume
chemical_list: D010100:Oxygen