Contracture caused by sodium removal in the pregnant rat myometrium.
The contracture produced by removal of the external Na was studied in the pregnant rat myometrium and this was compared with that of the non-pregnant myometrium. The Na-free contracture was small compared with spontaneous phasic contractions in the circular muscle of non-pregnant rat, but the contracture increased during pregnancy. On the other hand, in the longitudinal muscle, the contracture was large in both non-pregnant and pregnant myometria. The change in circular muscle did not seem to result from an increased sensitivity to the external Ca. Since the contracture induced by 40 mM K had properties similar to those of the Na-free contracture, it is likely that weak tension development in non-pregnant circular muscle is either due to a limited Ca influx or due to a low efficiency of the excitation-contraction coupling for the sustained contraction compared with the phasic contraction. A small contraction which was independent of the external Ca was observed in Na-free solution in the both layers of non-pregnant myometrium, but this was not observed in the longitudinal muscle of pregnant myometrium.
D000818:Animals; D005260:Female; D009215:Myometrium / Q000502:physiology; D011188:Potassium / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D051381:Rats; D012964:Sodium / Q000502:physiology*; D012996:Solutions; D014590:Uterine Contraction / Q000187:drug effects
D012996:Solutions; D012964:Sodium; D011188:Potassium