Effect of arginine vasopressin on arterial oxygen partial pressure in the chronically catheterized fetal lamb.
Fetal plasma 2,3-Diphosphoglycerate (2,3-DPG) and glucose levels were observed during infusion of arginine vasopressin into 6 chronically catheterized fetal lambs. Low dose infusion of arginine vasopressin (5-10 mIU/min.) did not change fetal arterial blood gases significantly. At a high concentration of vasopressin (20-40 mIU/min.), infusion for 60 minutes increased fetal arterial pO2 by approximately 5 mmHg (p less than 0.005 by paired t-test), and decreased pCO2 by approximately 2 mmHg (p less than 0.005 by paired t-test) without significant changes in pH. Neither low nor high dose infusion of arginine vasopressin was accompanied by significant changes in 2,3-DPG or the glucose level.
D019794:2,3-Diphosphoglycerate; D000818:Animals; D001127:Arginine Vasopressin / Q000502:physiology*; D001784:Blood Gas Analysis; D001786:Blood Glucose / Q000032:analysis; D002404:Catheterization; D004163:Diphosphoglyceric Acids / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D011247:Pregnancy; D012756:Sheep
D001786:Blood Glucose; D004163:Diphosphoglyceric Acids; D001127:Arginine Vasopressin; D019794:2,3-Diphosphoglycerate; D010100:Oxygen