Decreased skin superoxide dismutase activity by a single exposure of ultraviolet radiation is reduced by liposomal superoxide dismutase pretreatment.
The effect of a single exposure to UV radiation on skin superoxide dismutase (SOD) activity was examined in mice. A significant decrease in SOD activity was observed 24 and 48 h after UV irradiation, returning to the normal level by 72 h after irradiation. Decreased SOD activity after UV exposure was reduced by pretreatment with liposomal SOD (L-SOD). This protective effect of L-SOD may have potential clinical application for photodermatologic reactions.
D000818:Animals; D008081:Liposomes / Q000008:administration & dosage; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012867:Skin / Q000201:enzymology* / Q000528:radiation effects; D013482:Superoxide Dismutase / Q000378:metabolism* / Q000494:pharmacology; D014466:Ultraviolet Rays
D008081:Liposomes; D013482:Superoxide Dismutase