Effect of phencyclidine and two monohydroxy metabolites on 3H QNB binding in vivo in rats.
The purpose of these investigations was to determine if phencyclidine (PCP) and/or two of its major monohydroxy metabolites [1-(1-phenylcyclohexyl)4-hydroxy piperidine (4-OH-pip PCP) and 1-(1-phenyl-4-hydroxycyclohexyl) piperidine (4-OH-cyclo PCP)] influence 3H quinuclidinyl benzilate (QNB) binding in rat brain after in vivo administration. PCP and 4-OH-pip PCP but not 4-OH-cyclo PCP enhanced QNB binding. The effect was blocked by atropine. Since the dose of 4-OH-pip PCP necessary to alter QNB binding in rat brain is substantially higher than that required for PCP, this metabolite probably does not play a major role in the PCP effect on QNB binding in rat brain.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010622:Phencyclidine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D011812:Quinuclidines / Q000378:metabolism*; D011813:Quinuclidinyl Benzilate / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D011812:Quinuclidines; C031107:4-phenyl-4-piperidinocyclohexanol; D011813:Quinuclidinyl Benzilate; C042378:1-(1-phenylcyclohexyl)-4-phenyl-4-piperidinol; D001285:Atropine; D010622:Phencyclidine