title: [Treatment with superhigh corticosteroid doses (pulse therapy) of patients with the idiopathic nephrotic syndrome].
abstract: The results from the pulse therapy of 11 patients with severe nephrotic manifestations of idiopathic nephrotic syndrome are summarized, that had failed to respond to the preceding conventional corticosteroid treatment. Rapid improvement was attained in nine of the patients studied. Best were the results in the patients with "minimum" morphological alterations and with diffuse mesangial proliferation. Favourable effect was obtained also in the patients with glomerular sclerosis and hyalinosis. The failure of treatment in one of the female patients with mesangial proliferation is associated with the adverse unfavourable factors, and in one of the male-patients with glomerular sclerosis and hyalinosis--with severe morphological changes and exhausted functional potentialities of kidneys. The authors admit that the fast favourable effect by the therapeutic schedule used, make it a means of choice in forms of idiopathic nephrotic syndrome with a grave course and failing to respond to the routine treatment.
mesh_terms: D003520:Cyclophosphamide / Q000008:administration & dosage; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage*; D012074:Remission Induction; D013997:Time Factors
chemical_list: D003520:Cyclophosphamide; D011239:Prednisolone; D008775:Methylprednisolone
vernacular_title: Lechenie sŭs svrŭkhvisoki dozi kortikosteroidi ("pulsova terapiia") pri bolni s idiopatichen nefrozen sindrom.