Frozen maternal platelets for neonatal thrombocytopenia.
A case is reported of an alloimmunized, neonatal, thrombocytopenic patient who was successfully transfused with maternal platelets collected by cytapheresis and cryopreserved 3 months before delivery. Phlebotomy or cytapheresis of the mother immediately before delivery was avoided. Transfusion of maternal platelets over a 7-day period with aliquots containing an average of 7.1 X 10(10) platelets in 50 ml of plasma was possible. Satisfactory increases in platelet counts were sustained after transfusion.
D000328:Adult; D001803:Blood Transfusion; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D006801:Humans; D007231:Infant, Newborn; D017713:Platelet Transfusion; D011247:Pregnancy / Q000097:blood*; D013921:Thrombocytopenia / Q000151:congenital / Q000628:therapy*