[Effect of synthetic phenol antioxidants on the parietal pH value of the gastrointestinal tract in intact and vagotomized rats].
The influence of synthetic phenol antioxidants dibunol and BH-3 on the value of parietal pH has been studied in the stomach, duodenum, jejunum, ileum, caecum and rectum of intact and vagotomized rats 1, 7, 14, 30 and 60 days after treatment. It was shown that vagotomy leads to an increase in the stomach pH and to a decrease in pH in other parts of the gastrointestinal tract. Maximum BH-3 doses lead to pH increase in the stomach of intact rats. Chronic administration of therapeutic drug doses does not change pH value in control and vagotomized animals.
D000818:Animals; D000975:Antioxidants; D004064:Digestive System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006863:Hydrogen-Ion Concentration; D008297:Male; D010636:Phenols / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D000975:Antioxidants; D010636:Phenols
Vliianie sinteticheskikh fenol'nykh antioksidantov na velichinu pristenochnogo pH zheludochno-kishechnogo trakta intaktnykh i vagotomirovannykh krys.