Oxidation of glutathione and reduced pyridine nucleotides by the myotoxic and mutagenic aromatic amine, 1,2,4-triaminobenzene.
The myotoxic and mutagenic aromatic amine, 1,2,4-triaminobenzene, has been shown to oxidise glutathione and reduced pyridine nucleotides in a cyclic reaction which generates both superoxide radical and hydrogen peroxide. It is suggested that the process is initiated by the triaminobenzene radical, formed by autoxidation of the amine. This, by mediating the one-electron oxidation of GSH and NAD(P)H, is able to establish a radical chain-reaction leading to the formation of GSSG and NAD(P)+. This reaction may be of significance in the pathogenesis of the toxic effects of 1,2,4-triaminobenzene, not only by forming reactive free-radicals but also by compromising cellular defences against oxidative attack.
D000814:Aniline Compounds; D002374:Catalase / Q000378:metabolism; D005609:Free Radicals; D005978:Glutathione; D006861:Hydrogen Peroxide; D009243:NAD; D010084:Oxidation-Reduction; D013482:Superoxide Dismutase / Q000378:metabolism
D000814:Aniline Compounds; D005609:Free Radicals; D009243:NAD; C051091:1,2,4-triaminobenzene; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione