In vivo nutrient uptake by head and neck cancers.
The arteriovenous uptake differences for glucose, lactate, pyruvate, beta-hydroxybutyrate, and acetoacetate were measured in vessels across squamous cell carcinomas in ten selected patients with tumors of the head and neck. All tumors measured took up glucose, pyruvate, beta-hydroxybutyrate, and acetoacetate. They could either produce, take up, or maintain a constant level of lactate. These tumors demonstrate a heterogeneous affinity for various metabolites, including ketone bodies which are elevated in the nutritionally depleted, tumor-burdened patient.
D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006258:Head and Neck Neoplasms / Q000378:metabolism*; D006801:Humans; D006885:Hydroxybutyrates / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009747:Nutritional Physiological Phenomena; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid
D000090:Acetoacetates; D006885:Hydroxybutyrates; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; C016635:acetoacetic acid; D019289:Pyruvic Acid; D005947:Glucose; D020155:3-Hydroxybutyric Acid