Grooming behavior of spontaneously hypertensive rats.
In an open field spontaneously hypertensive rats (SHR) exhibited lower scores for grooming when compared to their normotensive controls, the Wistar-Kyoto rats (WKY). After i.c.v. injection of 1 microgram ACTH cumulative 50-min grooming scores were lower in SHR. Analysis of subscores indicated that the lesser effect of ACTH in SHR was especially prominent for headwashing and anogenital grooming. Moreover, a time course study revealed that the difference between SHR and WKY occurred in the first 6 observation periods of 5 min and thereafter disappeared. The results are discussed in the light of behavioral and central neurochemical differences between SHR and WKY.
D000818:Animals; D001921:Brain / Q000187:drug effects; D003366:Cosyntropin / Q000008:administration & dosage / Q000494:pharmacology; D006120:Grooming / Q000187:drug effects; D007276:Injections, Intraventricular; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D011921:Rats, Inbred WKY
D003366:Cosyntropin