title: Serial recording of VEPs to different stimuli in multiple sclerosis patients.
abstract: VEPs to different spatial frequencies (1,2,4 cycles per degree) and different stimulus configurations (vertical, horizontal gratings and checkerboard) were recorded in 47 Multiple Sclerosis patients and a corresponding group of control subjects. Serial recordings were performed in periods of 1-6 years. We show that the highest diagnostic yield in MS is for VEPs of higher spatial frequency than 1 cpd, and that vertical gratings give reliable results when high spatial frequencies are used, whereas checkerboard stimuli elicit consistent VEPs only when the check size is 30'-15' of arc of visual angle. The use of fine vertical grating patterns dissipates controversies dependent on "W" shaped VEPs.
mesh_terms: D000328:Adult; D005074:Evoked Potentials, Visual; D006801:Humans; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000503:physiopathology; D010364:Pattern Recognition, Visual; D010775:Photic Stimulation / Q000379:methods; D013997:Time Factors