title: Profound hypoglycemia with the addition of a tricyclic antidepressant to maintenance sulfonylurea therapy.
abstract: Cases of profound hypoglycemia after the initiation of tricyclic antidepressant therapy in two patients taking sulfonylureas are described. To the authors' knowledge, this is the first report of a potential drug interaction between tricyclic antidepressants and sulfonylureas.
mesh_terms: D000368:Aged; D002747:Chlorpropamide / Q000009:adverse effects*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy; D004316:Doxepin / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D008875:Middle Aged; D009661:Nortriptyline / Q000009:adverse effects*; D014042:Tolazamide / Q000009:adverse effects*
chemical_list: D004316:Doxepin; D014042:Tolazamide; D009661:Nortriptyline; D002747:Chlorpropamide