Diuretic-associated pancreatitis: a collective review and illustrative cases.
Three patients are presented as illustrative examples of severe necrotizing pancreatitis associated with diuretic therapy. The presumed initiating factor was use of a benzothiadiazine (chlorothiazide, hydrochlorothiazide) or phthalimidine (chlorthalidone) diuretic to control hypertension, after the exclusion of other etiologies. We present these illustrative cases and a collective review, emphasizing that pancreatitis associated with these widely prescribed medications can be fatal and may be more common that previously thought.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D002740:Chlorothiazide / Q000009:adverse effects; D002752:Chlorthalidone / Q000009:adverse effects; D004232:Diuretics / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000139:chemically induced*
D004232:Diuretics; D002740:Chlorothiazide; D002752:Chlorthalidone