title: Effects of hypothalamic stimulation and lesion on adrenal nerve activity.
abstract: Activity changes of efferent adrenal sympathetic nerves in response to bilateral manipulations of the hypothalamus, partly after intra-third cerebroventricular injection of 2-deoxy-D-glucose (2-DG) were investigated in anesthetized rats. Stimulation of the middle part of the lateral hypothalamic area (LHAm) increased adrenal nerve activity, whereas lesion caused rapid and remarkable decrease. Stimulation of the anterior part of the LHA (LHAa) tended to decrease the activity, and lesion produced either rapid decrease or late moderate increase. Stimulation of the ventromedial hypothalamic nucleus (VMH) did not affect the nerve activity, but lesion increased it gradually and then remarkably. Cerebroventricular infusion of 2-DG caused remarkable increase in activity that was suppressed by LHAm lesion. Subsequent infusion of 2-DG during the period of suppressed activity was no longer effective. The increased firing rate after 2-DG was suppressed by stimulation of the VMH, whereas lesion caused no change. These findings indicate that the central regulation of adrenal nerve activity is connected with individual hypothalamic regions and consequently depends on the degree and mode of activation of the sympathoadrenal system.
mesh_terms: D000200:Action Potentials; D000311:Adrenal Glands / Q000294:innervation*; D000818:Animals; D003847:Deoxyglucose / Q000378:metabolism; D004558:Electric Stimulation; D005260:Female; D006339:Heart Rate; D007031:Hypothalamus / Q000502:physiology*; D008297:Male; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology*; D014697:Ventromedial Hypothalamic Nucleus / Q000502:physiology
chemical_list: D003847:Deoxyglucose