title: [Clinical evaluation of aztreonam in the prevention and therapy of infections in patients subjected to neurosurgical intervention].
abstract: Twenty-six neurosurgery patients were given prophylactic treatment with Aztreonam at a dose of 1 g every 8 hours (30 mg/kg every 12 hours in children) for 8-12 days after the operation. In 18 cases 300 mg Clindamycin was also given every 8 hours for 8 days. No local or general infections arose in the postoperative period. Three patients with infections caused by susceptible bacteria were given 1 g Aztreonam every 6 hours (30 mg/kg every 8 hours in children) for 8 days. In all cases all clinical and microbiological signs of the infection had disappeared by the end of treatment. Apart from one episode of mild nausea no side effects were noted. Aztreonam is therefore considered a safe and effective drug for the treatment and prophylaxis of postoperative infections in neurosurgery.
mesh_terms: D000328:Adult; D000368:Aged; D001398:Aztreonam / Q000008:administration & dosage / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009493:Neurosurgery; D011183:Postoperative Complications / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D001398:Aztreonam
vernacular_title: Valutazione clinica dell'aztreonam nella profilassi e terapia delle infezioni in pazienti sottoposti ad intervento neurochirurgico.