[Effect of diuretics on the activity of the blood kallikrein-kinin system in experimental inflammation].
Experimental inflammatory edema induced by subplantar administration of dextran was shown to activate the blood kallikrein-kinin system in rats. Furosemide, dichlothiazide and ethacyrnic acid (50 mg/kg) prevented this effect. Ethacrynic acid exerted the most pronounced action.
D000818:Animals; D004232:Diuretics / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007249:Inflammation / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D007610:Kallikreins / Q000097:blood*; D007705:Kinins / Q000097:blood*; D008297:Male; D051381:Rats
D004232:Diuretics; D007705:Kinins; D007610:Kallikreins
Vliianie diuretikov na aktivnost' kallikrein-kininovoĭ sistemy krovi v usloviiakh éksperimental'nogo vospaleniia.