title: Psoriasis specific chromosomal proteins, antibodies against them and disease activity.
abstract: It has been demonstrated recently that the lymphoid cells of patients with psoriasis have antibodies directed against the psoriasis specific non-histone proteins. A conceptual hypothesis for the role of these antibodies in the pathogenesis of psoriasis presented in this communication, is as follows. Perhaps the psoriasis specific non-histone proteins following phosphorylation bind to histone which keeps psoriasis gene(s) repressed. This may result in the displacement of histone from the DNA. Antibodies against psoriasis specific non-histone proteins may facilitate the displacement of histone. DNA set free, possibly containing psoriasis gene(s), can then be transcribed into RNA causing a shift of the resting pool of keratinocytes in the symptom-free skin of psoriasis patients to the proliferating pool of keratinocytes in the psoriasis lesions.
mesh_terms: D000918:Antibody Specificity; D001323:Autoantibodies / Q000276:immunology*; D002455:Cell Division; D002467:Cell Nucleus / Q000276:immunology; D002868:Chromosomal Proteins, Non-Histone / Q000276:immunology*; D006801:Humans; D010750:Phosphoproteins / Q000276:immunology / Q000502:physiology; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000276:immunology / Q000473:pathology
chemical_list: D001323:Autoantibodies; D002868:Chromosomal Proteins, Non-Histone; D010750:Phosphoproteins