Complementary DNA cloning of complement C8 beta and its sequence homology to C9.
The complete amino acid sequence of mature C8 beta has been derived from the DNA sequence of a cDNA clone identified by expression screening of a human liver cDNA library. Comparison with the amino acid sequence of C9 shows an overall homology with few deletions and insertions. In particular, the cysteine-rich domains and membrane-inserting regions of C9 are well conserved. These findings are discussed in relation to a possible mechanism of membrane attack complex formation.
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D003185:Complement C8 / Q000235:genetics*; D003186:Complement C9 / Q000235:genetics*; D004247:DNA / Q000032:analysis*; D006801:Humans; D008099:Liver / Q000378:metabolism; D046911:Macromolecular Substances; D012689:Sequence Homology, Nucleic Acid
D003185:Complement C8; D003186:Complement C9; D046911:Macromolecular Substances; D004247:DNA