[Action of hepatoprotective agents in a tetracycline lesion of the liver].
Comparative efficacy of hepatoprotective agents in tetracycline affection of the liver is discussed. The affection was induced by daily intragastric administration of the antibiotic in a dose of 0.5 g/kg body weight to Wistar albino rats. The level of the hepatocyte affection and the efficacy of the hepatoprotective agents were judged by changes in the biligenic, glycogen producing, antitoxic and absorbing-excretory functions of the liver and the activity of lipid peroxidation (LPO) and serum enzymes. In acute tetracycline intoxication there was observed suppression of cholopoiesis, induction of LPO, increased permeability of hepatocyte membranes, lowered stabilizing activity of bile and decreased detoxicating and absorbing-excretory capacity of the liver. The highest correcting effect of the hepatoprotective agents was shown with respect to cholopoiesis, carbohydrate metabolism and lipoperoxidation of hepatocyte membranes. The efficacy of silibor in tetracycline affection of the liver was close to that of Essentiale and legalon and superior to that of LIV-52.
D000818:Animals; D001646:Bile / Q000187:drug effects; D002392:Catechin / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D010713:Phosphatidylcholines / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012838:Silymarin / Q000627:therapeutic use; D013752:Tetracycline / Q000633:toxicity*
D004338:Drug Combinations; D010713:Phosphatidylcholines; D010936:Plant Extracts; D012838:Silymarin; C011246:essential 303 forte; C002614:Liv 52; D002392:Catechin; D013752:Tetracycline
Deĭstvie gepatozashchitnykh sredstv pri tetratsiklinovom porazhenii pecheni.