title: Are health care workers at risk for infection during an outbreak of nosocomial Legionnaires' disease?
abstract: We studied data from 500 health care workers to answer the question: Are health care workers at risk for infection during an outbreak of nosocomial Legionnaires' disease? These workers were employed at a hospital where eight cases of nosocomial Legionella pneumophila serogroup 1 pneumonia occurred over a 4-week period. The source was potable water. Acute-phase blood samples were collected on the day the water supply was decontaminated, convalescent samples were collected 4 to 6 weeks later from 373 subjects, and a single serum sample was obtained from an additional 127 subjects. Antibody titers to L. pneumophila were determined by an indirect immunofluorescent antibody (IFA) technique and by a microagglutination assay with the epidemic strain as the test antigen. Subjects who had an IFA titer of greater than or equal to 1:256 were retested with an anti-human IgM conjugate. None of the 373 health care workers had a fourfold rise in antibody titer. The geometric mean antibody titer of 73.8 for the 500 health care workers was significantly higher than that of 68.1 for 976 blood donors (p less than 0.01). Only 2.4% had recent infection as evidenced by a microagglutination test, despite the fact that 84% were susceptible. We conclude that in the setting of a short-term outbreak of Legionnaires' disease caused by contaminated potable water the risk of infection among health care workers is low: 2.4% or less.
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000906:Antibodies / Q000032:analysis; D003428:Cross Infection / Q000097:blood / Q000276:immunology / Q000635:transmission*; D006745:Hospital Bed Capacity, 300 to 499; D006801:Humans; D007877:Legionnaires' Disease / Q000097:blood / Q000276:immunology / Q000635:transmission*; D009674:Nova Scotia; D010564:Personnel, Hospital; D012306:Risk
chemical_list: D000906:Antibodies