Topical vancomycin formulation for methicillin-resistant Staphylococcus epidermidis blepharoconjunctivitis.
We successfully treated two patients with severe Staphylococcus epidermidis blepharoconjunctivitis by means of a topical vancomycin hydrochloride solution (50 mg/ml) prepared with sterile water. Aqueous vancomycin preparations, however, cause significant ocular irritation probably because of low pH and osmolality values. Solutions prepared with normal saline (5 mg/ml) and phosphate-buffered artificial tears (5 mg/ml and 50 mg/ml) were significantly less irritating and possessed equivalent in vitro antimicrobial activity. Topical vancomycin should be used only when commercially available antibiotics are inadequate.
D000287:Administration, Topical; D000368:Aged; D001762:Blepharitis / Q000188:drug therapy / Q000209:etiology*; D003231:Conjunctivitis / Q000188:drug therapy / Q000209:etiology*; D004341:Drug Evaluation; D005141:Eyelid Diseases / Q000209:etiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008712:Methicillin; D009883:Ophthalmic Solutions; D009994:Osmolar Concentration; D010403:Penicillin Resistance; D013203:Staphylococcal Infections; D013212:Staphylococcus epidermidis; D014640:Vancomycin / Q000008:administration & dosage* / Q000627:therapeutic use
D009883:Ophthalmic Solutions; D014640:Vancomycin; D008712:Methicillin