[Carcinogenic action of soot extracts and the composition of the aromatic polycyclic hydrocarbons in emissions of the coke chemical industry].
Carcinogenicity of the extract of "unorganized" emission of coke-oven batteries of the coke and by-product processes, 15 polycyclic hydrocarbons (PAH), solution of 4 carcinogenic PAH and benz(a)pyrene (BP) was studied in longterm experiments on (CBAXC57Bl/6)F1 hybrid mice. 1.5 ml of olive oil containing 1 mg of BP or the respective amount of PAH proportionally to their content in the extract were administered to each mouse. The sarcomas developed in 46.6% of mice which had received injections of the extract and in 95 to 100% of mice which had received injection of PAH and BP solution. Thus, the results demonstrated that besides carcinogenic PAH the emissions contain substances which inhibit the tumour development. Our data confirm a possibility of using BP as an indicator in the evaluation of carcinogenicity of industrial emission discharges of the coke and by-product processes.
D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D000818:Animals; D002244:Carbon / Q000032:analysis / Q000633:toxicity*; D002617:Chemical Industry; D003031:Coal / Q000009:adverse effects*; D003077:Coke / Q000009:adverse effects* / Q000032:analysis; D004391:Dust / Q000009:adverse effects / Q000032:analysis; D007220:Industrial Waste / Q000009:adverse effects* / Q000032:analysis; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000453:epidemiology; D011083:Polycyclic Compounds / Q000032:analysis / Q000633:toxicity*; D014586:USSR
D000393:Air Pollutants; D003031:Coal; D003077:Coke; D004391:Dust; D007220:Industrial Waste; D011083:Polycyclic Compounds; D002244:Carbon
Kantserogennoe deĭstvie ékstraktov sazhi i sostab politsiklicheskikh aromaticheskikh uglevodorodov v vybrosakh koksokhimicheskogo proizvodstva.