Thin-layer chromatographic examination of the degradation of centbucridine in aqueous solutions.
Centbucridine (9-n-butylamino-1,2,3,4-tetrahydroacridine) is a new potent local anaesthetic. Its degradation in aqueous solutions has been investigated with the help of thin-layer chromatography. Apart from the degradation products 9-amino-1,2,3,4-tetrahydroacridine and 1,2,3,4-tetrahydroacridone, acridone was also found to be present. It is shown that the acridone is produced not through a dehydrogenation reaction but some other unknown pathway.
D000609:Aminoacridines / Q000032:analysis*; D000779:Anesthetics, Local / Q000032:analysis*; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013619:Tacrine / Q000031:analogs & derivatives / Q000032:analysis*
D000609:Aminoacridines; D000779:Anesthetics, Local; D012996:Solutions; D013619:Tacrine; C037014:centbucridine