Blood concentrations of 2,3-butanedione monoxime and some blood biochemical changes in Bubalus bubalis after intramuscular administration of this cholinesterase reactivator.
The blood levels of cholinesterase reactivator 2,3-butanedione monoxime were determined in buffalo calves following single intramuscular doses of 20 and 50 mg/kg body weight. Blood cholinesterases and other enzymatic activities were monitored at various times. The drug was rapidly absorbed with half-life of 0.09-0.12 h. The peak 2,3-butanedione monoxime blood concentrations of 24.7 +/- 0.3 and 38.9 +/- 1.7 micrograms/ml occurred at 10 min after 20 and 50 mg/kg doses, respectively. The elimination half-life varied between 3.05 +/- 0.12 and 3.80 +/- 0.19 h. Lack of adverse effect of 2,3-butanedione monoxime on blood cholinesterases and other enzymes indicated that intramuscular doses as high as 50 mg/kg may be safely employed in buffaloes.
D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D002020:Buffaloes / Q000097:blood*; D002074:Butanones / Q000097:blood*; D002801:Cholinesterase Reactivators / Q000008:administration & dosage / Q000097:blood*; D002802:Cholinesterases / Q000097:blood; D003931:Diacetyl / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood*; D006207:Half-Life; D007273:Injections, Intramuscular / Q000662:veterinary; D007700:Kinetics; D008297:Male
D001798:Blood Proteins; D002074:Butanones; D002801:Cholinesterase Reactivators; C004717:diacetylmonoxime; D002802:Cholinesterases; D003931:Diacetyl