Sensory irritation of methylisocyanate vapor.
The respiratory-depression (RD) profile in mice exposed to methylisocyanate (MIC) vapor is reported. The RD50 value calculated from this profile was 2.9 (2.7-3.2) ppm. Concentrations of MIC that have been reported to be unbearable in humans were of approximately the same magnitude as RD50 concentrations in mice for brief exposures.
D000818:Animals; D000986:Antisickling Agents / Q000032:analysis / Q000633:toxicity*; D003485:Cyanates / Q000032:analysis / Q000633:toxicity*; D007509:Irritants; D017953:Isocyanates; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012119:Respiration / Q000187:drug effects
D000986:Antisickling Agents; D003485:Cyanates; D007509:Irritants; D017953:Isocyanates; C008461:methyl isocyanate