Profound hypoglycemia with the addition of a tricyclic antidepressant to maintenance sulfonylurea therapy.
Cases of profound hypoglycemia after the initiation of tricyclic antidepressant therapy in two patients taking sulfonylureas are described. To the authors' knowledge, this is the first report of a potential drug interaction between tricyclic antidepressants and sulfonylureas.
D000368:Aged; D002747:Chlorpropamide / Q000009:adverse effects*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy; D004316:Doxepin / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D008875:Middle Aged; D009661:Nortriptyline / Q000009:adverse effects*; D014042:Tolazamide / Q000009:adverse effects*
D004316:Doxepin; D014042:Tolazamide; D009661:Nortriptyline; D002747:Chlorpropamide