In vivo and in vitro effect of toxic and radio-detoxified endotoxin preparations on chemiluminescence of peritoneal cells of mice.
Chemiluminescence (CL) of peritoneal cells was investigated one and five days after injection of toxic and radio-detoxified endotoxin. The CL was triggered by toxic and radio-detoxified endotoxin. The radio-detoxified endotoxin has less pronounced in vivo activating effect than the toxic endotoxin. As triggering agent the toxic endotoxin was more effective than the radio-detoxified endotoxin. However, the radio-detoxified endotoxin has preserved some in vivo activating and in vitro triggering effect.
D000276:Adjuvants, Immunologic; D000818:Animals; D004731:Endotoxins / Q000494:pharmacology* / Q000528:radiation effects; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008163:Luminescent Measurements; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D010101:Oxygen Consumption; D010529:Peritoneal Cavity / Q000166:cytology
D000276:Adjuvants, Immunologic; D004731:Endotoxins; D008070:Lipopolysaccharides