title: The effects of haem arginate and haematin upon the allylisopropylacetamide induced experimental porphyria in rats.
abstract: Biochemical disorders caused by allylisopropylacetamide in various animal species resemble human acute intermittent porphyria. The antiporphyrogenic efficacy and potency of haem arginate, a new haem compound, were compared with those of haematin in experimental porphyria of rats. Both haem arginate and haematin dose-dependently decreased the urinary excretions of porphyrin precursors. They inhibited significantly the induction of hepatic delta-aminola-evulinic acid synthase. Haem arginate and haematin could restore the activity of haem oxygenase and after higher doses they increased the activity. The dose-effect relationships of the two haem compounds were demonstrated.
mesh_terms: D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000502:Allylisopropylacetamide; D000818:Animals; D001120:Arginine / Q000627:therapeutic use*; D006418:Heme / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006427:Hemin / Q000627:therapeutic use*; D008099:Liver / Q000201:enzymology; D008297:Male; D011162:Porphobilinogen / Q000652:urine; D011164:Porphyrias / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000502:Allylisopropylacetamide; D006418:Heme; D006427:Hemin; D011162:Porphobilinogen; D001120:Arginine; D000624:5-Aminolevulinate Synthetase; C048849:heme arginate