title: 2',5'-Oligoadenylate synthetase and interferon in peripheral blood after rubella, measles, or mumps live virus vaccine.
abstract: The temporal activation of the human interferon system by infection with virus was studied by serial measurements of both interferon in serum and activity of 2',5'-oligo adenylate synthetase in peripheral mononuclear leukocytes. A frequency distribution of baseline values of synthetase was established for normal individuals. Following subcutaneous inoculation of rubella vaccine virus, serum interferon rose briefly with a peak on Day 14. The peak concentration of synthetase also occurred on Day 14 but remained elevated for greater than 1 week. After measles virus, serum interferon did not rise above baseline, but synthetase peaked on Day 14 and remained elevated. Subcutaneous inoculation of mumps vaccine virus was associated with a brief period of elevation of the synthetase and no interferon in the serum. Thus, the determination of synthetase levels in tissue may be useful in some situations to reflect a small or transient elevation of endogenous interferon.
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000097:blood*; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology*; D007370:Interferon Type I / Q000097:blood*; D008458:Measles Vaccine / Q000494:pharmacology*; D009108:Mumps Vaccine / Q000494:pharmacology*; D012411:Rubella Vaccine / Q000494:pharmacology*; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000494:pharmacology
chemical_list: D007369:Interferon Inducers; D007370:Interferon Type I; D008458:Measles Vaccine; D009108:Mumps Vaccine; D012411:Rubella Vaccine; D014613:Vaccines, Attenuated; D015088:2',5'-Oligoadenylate Synthetase