Drug-specific Fab therapy in drug overdose.
The use of digoxin-specific fragments, antigen-binding (Fab) for antidotal therapy of severe digitalis intoxication is rapidly becoming a treatment of choice. Furthermore, studies with this mode of drug-specific therapy using Fab specific for desipramine and for phencyclidine suggest that this treatment may be applicable to a variety of other drugs or drug classes. As Fab technology has advanced, so have laboratory methods for monitoring the efficacy of treatment.
D000931:Antidotes / Q000627:therapeutic use*; D003891:Desipramine / Q000506:poisoning; D004077:Digoxin / Q000506:poisoning; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use; D010622:Phencyclidine / Q000506:poisoning; D011041:Poisoning / Q000628:therapy*
D000931:Antidotes; D007140:Immunoglobulin Fab Fragments; C050199:digoxin antibodies Fab fragments; D004077:Digoxin; D010622:Phencyclidine; D003891:Desipramine