title: Does the nail bed really regenerate?
abstract: From observations of nail bed injuries, the regeneration of the nail bed seemed evident. The nail bed regenerated well in the presence of the nail matrix and poorly in its absence, suggesting that the nail bed regenerated from the nail matrix. Full-thickness skin graft or flap coverage of nail bed defects resulted in the good nail bed regeneration. The nail bed grew back, pushing the graft or the flap distally. The regenerated nail beds were about 70 percent of normal size in guillotine-type amputations and about 90 percent in the presence of an intact distal phalanx. The difference between full- and split-thickness skin grafts seemed to be adherence to the phalangeal bone, the former giving way to the advancing nail bed and the latter staying in the way. In addition, the destination of the moving nail bed cells was discussed.
mesh_terms: D000328:Adult; D000673:Amputation, Traumatic / Q000503:physiopathology / Q000601:surgery; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009262:Nails / Q000293:injuries / Q000502:physiology* / Q000601:surgery; D012038:Regeneration; D013524:Surgical Flaps