title: The influence of social isolation, hypoxia and immobilization on potassium-stimulated dopamine release from telencephalon slices of mice.
abstract: Dopamine release from mice telencephalon slices was investigated following immobilization or hypobaric hypoxia exposure during periods of social isolation of different length which itself affects dopamine release in a characteristic manner. Isolation initially results in a decreasing release, which is compensated at the end by adaptive processes. The decrease of dopamine release induced by immobilization is highly dependent on the foregoing isolation. On the other hand, a hypoxia-induced decrease of release always dominates the results. Adaptive processes in consequence of social isolation are supposed to be important in relation to immobilization effects but not to hypoxia-induced changes.
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D000860:Hypoxia / Q000150:complications*; D008297:Male; D051379:Mice; D011188:Potassium / Q000494:pharmacology*; D012149:Restraint, Physical; D012934:Social Isolation; D013312:Stress, Physiological / Q000503:physiopathology*; D013687:Telencephalon / Q000378:metabolism*
chemical_list: D011188:Potassium; D004298:Dopamine