Properdin factor B polymorphism in four Sardinian villages.
A sample of healthy unrelated individuals was typed for properdin factor B (Bf) polymorphism in four Sardinian villages. Two villages, Desulo and Tonara, are located in the highlands; the other two, Orosei and Galtellì, are located in the lowlands. No heterogeneity was found between the highland and the lowland villages, whereas a significant difference was found between the Sardinian villages and continental Italy. The allele Bf-F1 shows the highest gene frequency so far observed. Typically Sardinian is the gametic association (haplotype) HLA-A30, Cw5, B18, BfF1, DR3.
D000483:Alleles; D011415:Complement Factor B / Q000235:genetics*; D004792:Enzyme Precursors / Q000235:genetics*; D005787:Gene Frequency; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics; D006681:HLA-D Antigens / Q000235:genetics; D006801:Humans; D007558:Italy; D011110:Polymorphism, Genetic
D004792:Enzyme Precursors; D006680:HLA Antigens; D006681:HLA-D Antigens; D011415:Complement Factor B