Effect of human urinary trypsin inhibitor on granulocyte elastase activity.
A human urinary trypsin inhibitor preparation, MR-20, strongly inhibited granulocyte elastase activity. The concentration of MR-20 causing 50% inhibition of the hydrolysis of Suc(Ala) 3pNA by granulocyte elastase was estimated to be 6.4 X 10(-8) M (11 U/ml).
D006023:Glycoproteins / Q000494:pharmacology*; D006098:Granulocytes / Q000201:enzymology*; D006801:Humans; D006868:Hydrolysis; D007700:Kinetics; D009842:Oligopeptides; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*
D006023:Glycoproteins; D009842:Oligopeptides; C015516:succinyl-trialanine-4-nitroanilide; D010196:Pancreatic Elastase; C028665:urinastatin