title: Protection by fentanyl against cardiac dysrhythmias during induction of anaesthesia.
abstract: The effect of fentanyl on electrocardiographic changes during anaesthetic induction was studied in 113 adults and 77 children. The adults were pretreated with fentanyl 1, 2 or 3 micrograms kg-1 and the children received fentanyl 1 or 2 micrograms kg-1 as pretreatment. The control groups received no pretreatment. Two minutes after the pretreatment, thiopentone 5 mg kg-1 was injected followed by succinylcholine 1.5 mg kg-1 before laryngoscopy and intubation. In control adults, ventricular ectopic beats (VEB) occurred in 26% of the patients whereas fentanyl in all doses totally prevented them. In children, the incidence of VEB was 22% in the control group whereas both doses of fentanyl prevented the occurrence of VEB. In any doses, fentanyl did not prevent the prolongation of QT interval after succinylcholine.
mesh_terms: D000328:Adult; D000758:Anesthesia / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D004562:Electrocardiography; D005283:Fentanyl / Q000627:therapeutic use*; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D007442:Intubation, Intratracheal; D008875:Middle Aged; D011897:Random Allocation
chemical_list: D005283:Fentanyl