title: Effects of kallidinogenase on urinary kallikrein excretion and plasma prostanoid concentrations in patients with essential hypertension.
abstract: The effects of kallidinogenase on urinary kallikrein excretion, plasma immunoreactive prostanoids and platelet aggregation were investigated in patients with essential hypertension. Urinary kallikrein excretion and plasma 6-keto PGF1 alpha concentration were significantly decreased in these patients. Significant decreases in blood pressure, as well as significant increases of urinary kallikrein excretion and plasma 6-keto PGF1 alpha concentration after kallidinogenase administration were also observed.
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism*; D007610:Kallikreins / Q000494:pharmacology* / Q000627:therapeutic use / Q000652:urine*; D008297:Male
chemical_list: D015121:6-Ketoprostaglandin F1 alpha; D007610:Kallikreins