[Benzoyl-kallikrein: kallikrein activity and kinin generation in plasma].
The inactive acyl-derivative benzoyl-kallikrein was prepared from porcine pancreatic kallikrein. By deacylation the enzymatically active kallikrein was generated in plasma from benzoyl-kallikrein demonstrated by means of its amidolytic activity. Benzoyl-kallikrein was protected from being inactivated by plasma inhibitors. Therefore, the kallikrein activity in plasma was higher following incubation of benzoyl-kallikrein than following incubation of the free enzyme. A comparatively high kinin activity was found in rabbit plasma. In human plasma, this effect was prevented by rapid degradation of kinin.
D000818:Animals; D007610:Kallikreins / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D007705:Kinins / Q000097:blood*; D010179:Pancreas / Q000201:enzymology; D013552:Swine
D007705:Kinins; C050271:benzoylkallikrein; D007610:Kallikreins
Benzoyl-Kallikrein: Kallikreinaktivität und Kininbildung im Plasma.