New benzofuran-imidazoles as antimycotic agents. II. In vitro studies.
Ten new imidazole derivatives, benzofuran-imidazoles, were studied in vitro to establish their antimycotic activity against 70 fungal strains, in comparison with three known imidazoles and, for the dermatophytes only, griseofulvin. A very high inhibitory activity against dermatophytes was shown by five of the new substances. The other filamentous fungi and yeasts showed a more marked variation in their susceptibility. However a good sensitivity of some isolates of Candida albicans and other yeasts was seen.
D000935:Antifungal Agents; D003883:Arthrodermataceae / Q000187:drug effects; D001572:Benzofurans / Q000494:pharmacology*; D003022:Clotrimazole / Q000494:pharmacology; D004464:Econazole / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006118:Griseofulvin / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015003:Yeasts / Q000187:drug effects
D000935:Antifungal Agents; D001572:Benzofurans; D007093:Imidazoles; D006118:Griseofulvin; D004464:Econazole; D003022:Clotrimazole; C036596:bifonazole