The newborn rabbit: a model for studying hypoxemia-induced renal changes.
The newborn rabbit was used as an experimental model for studying renal changes during normocapnic hypoxemia. Renal extraction of p-aminohippuric acid (PAH), as assessed in 15 normoxemic and 8 hypoxemic rabbits amounted to 54.6 +/- 3.7 and 45.7 +/- 4.6%, respectively (NS). Changes in glomerular filtration rate (GFR), and renal blood flow (RBF) as assessed by inulin and PAH clearances, respectively, were determined during normoxemia and subsequent hypoxemia in 8 additional anesthetized and mechanically ventilated newborn rabbits. Normocapnic hypoxemia (PaO2 = 38.6 +/- 2.1 mm Hg) induced a significant fall in GFR from 2.10 +/- 0.21 to 1.51 +/- 0.18 ml/kg/min (p less than 0.01), in filtration fraction (p less than 0.01) and U/P inulin ratio (p less than 0.01). RBF, renal vascular resistance and urine flow rate did not change significantly. In comparison with other immature animal species the newborn rabbit appears a valuable and inexpensive model for the study of acute hypoxemia-induced renal changes.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001238:Asphyxia Neonatorum / Q000503:physiopathology*; D004195:Disease Models, Animal / Q000503:physiopathology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D007231:Infant, Newborn; D007668:Kidney / Q000503:physiopathology*; D007677:Kidney Function Tests; D011817:Rabbits / Q000502:physiology*; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology*; D014556:Urine / Q000032:analysis; D010130:p-Aminohippuric Acid / Q000652:urine
D010130:p-Aminohippuric Acid