Demonstration of growth-inhibitory as well as growth-stimulatory factors in medium conditioned by lung lavage cells stimulated with a chemotactic factor secreted by jaagsiekte tumour cells.
Both growth-inhibitory and growth-stimulatory factors were detected in vitro in medium from chemotactically stimulated cultures of lung lavage cells. The macrophage component of the lavage cells was found to produce a growth stimulatory factor that was replaced by a growth inhibitory factor following chemotactic factor stimulation.
D000818:Animals; D002478:Cells, Cultured; D002630:Chemotactic Factors / Q000378:metabolism*; D006131:Growth Inhibitors / Q000378:metabolism*; D006133:Growth Substances / Q000096:biosynthesis*; D008264:Macrophages; D011648:Pulmonary Adenomatosis, Ovine / Q000378:metabolism*; D011650:Pulmonary Alveoli / Q000473:pathology; D012756:Sheep
D002630:Chemotactic Factors; D006131:Growth Inhibitors; D006133:Growth Substances