[Follow-up studies of donors and recipients of HIV antibody-positive blood products].
In a retrospective study the rate of HIV (LAV/HTLV-III)-infected recipients of blood units (excluding haemophiliacs) issued before HIV antibody testing became routine in 1985 was investigated. Screening of 200,000 donations yielded 24 seropositive blood donors. Of these 17 were homo- or bisexual, one subsequently known to take drugs by i.v. injection, one had received donor blood, and in five there was no information concerning sexual preference. Ten seropositive multiple blood donors (mean of 17.6 donations) and the 42 potentially infected units donated between 1982 and 1985 were examined in detail. Blood donations from infected first-time donors were discarded. Nine recipients were found to be seropositive (one case of transfusion-associated AIDS), five were seronegative. Both groups were evaluated clinically and immunologically. Ten recipients had died in the intervening time, and in 15 cases it proved impossible to determine whether the donated and incriminated blood had in fact been transfused. It is likely that there will be an increase in transfusion-associated AIDS over the next 3-5 years, before preventive measures of HIV antibody screening and voluntary exclusion of donors at risk will prove to be effective.
D000163:Acquired Immunodeficiency Syndrome / Q000635:transmission; D000914:Antibodies, Viral / Q000302:isolation & purification*; D001782:Blood Donors; D005188:False Negative Reactions; D005260:Female; D006678:HIV / Q000276:immunology*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D065227:Transfusion Reaction
D000914:Antibodies, Viral
Nachuntersuchung von Spendern und Empfängern HIV-Antikörper-positiver Blutkonserven.