title: Further evidence for hepatic control of salt intake in rats.
abstract: We examined the contributions of oral and hepatic factors to the control of salt intake in rats made "salt hungry" by combined dietary sodium restriction and furosemide treatment. A 7.5-ml preload of 0.5 M NaCl, which was either voluntarily ingested or slowly infused (7.5 ml/90 min) into the hepatic portal vein, decreased subsequent 0.5 M NaCl intake by approximately 7.5 ml in both cases. Hepatic portal infusions were probably acting in the liver because slow jugular infusions (7.5 ml/90 min) did not influence salt drinking, although rapid (7.5 ml/5 min) infusions by both routes reduced salt intake. If salt was ingested but drained through a gastric cannula, rats showed little sign of reducing salt in a 2-h test. These results suggest that the quantity of salt ingested by salt-hungry rats is regulated by a postabsorptive mechanism that is probably located in the liver.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002404:Catheterization; D004032:Diet; D005665:Furosemide / Q000494:pharmacology; D008099:Liver / Q000502:physiology*; D008102:Liver Circulation; D051381:Rats; D012964:Sodium / Q000008:administration & dosage / Q000172:deficiency / Q000502:physiology*; D013997:Time Factors; D014882:Water-Electrolyte Balance
chemical_list: D005665:Furosemide; D012964:Sodium