Calcitonin as a feeding suppressant: localization of central action to the cerebral III ventricle.
Calcitonin suppresses food and water intake. To further study this effect of calcitonin, rats were subjected to various intra-cerebroventricular (ICV) applications of calcitonin. The results show: (1) Intra-third ventricular (III-ICV) infusion of calcitonin dose-dependently decreased food intake with short- and long-term effects; (2) Potency was decreased by using non-siliconized materials; (3) Potency decreased with age of rats; (4) Infusion into the aqueduct and cisterna magna decreased short- and long-term food intake less than III-ICV administration; (5) Aqueduct obstruction did not affect feeding suppression by III-ICV calcitonin. Aqueduct obstruction did not affect dipsogenic response to III-ICV infusion of angiotensin II; (6) Results of water intake and food to water intake ratios suggest a greater calcitonin effect on food intake than on water intake. The evidence suggests that the hypothalamus is a main locus for suppression of food intake by ICV administered calcitonin.
D000818:Animals; D001931:Brain Mapping; D002116:Calcitonin / Q000031:analogs & derivatives / Q000494:pharmacology*; D002552:Cerebral Ventricles / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002116:Calcitonin; C012755:elcatonin