Bacteremia caused by a lactose-fermenting, multiply resistant Salmonella typhi strain in a patient recovering from typhoid fever.
A female patient suffered a typical attack of typhoid fever due to a lactose-negative, fully susceptible Salmonella typhi strain. During convalescence she became febrile, and a lactose-fermenting S. typhi strain resistant to ampicillin, chloramphenicol, tetracycline, and trimethoprim was isolated from blood culture. This isolated was shown to harbor a plasmid which cotransferred lactose fermentation and antibiotic resistance.
D000293:Adolescent; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001434:Bacteriophage Typing; D002701:Chloramphenicol / Q000494:pharmacology; D004269:DNA, Bacterial / Q000032:analysis; D005260:Female; D005285:Fermentation; D006801:Humans; D007785:Lactose / Q000378:metabolism; D010403:Penicillin Resistance / Q000235:genetics; D011815:R Factors; D012485:Salmonella typhi / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D018805:Sepsis / Q000382:microbiology*; D012703:Serotyping; D013752:Tetracycline / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology; D014435:Typhoid Fever / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D002701:Chloramphenicol; D000667:Ampicillin; D014295:Trimethoprim; D013752:Tetracycline; D007785:Lactose