In vitro activity of cefpirome (HR810) against antibiotic-resistant gram-positive and gram-negative bacteria including organisms with inducible resistance.
The activity of cefpirome (HR810) was compared with seven beta-lactam antibiotics against selected gram-positive and gram-negative bacteria. Cefpirome was the most active antibiotic tested against all groups of Enterobacteriaceae; 46% of the isolates of Pseudomonas aeruginosa were inhibited by less than or equal to 8 micrograms/ml of cefpirome. Fifty percent of the oxacillin-resistant Staphylococcus aureus isolates and 82% of the Streptococcus faecalis isolates were inhibited by less than or equal to 8 micrograms/ml of cefpirome. All Enterobacteriaceae and two of five P. aeruginosa isolates that were induced to produce beta-lactamase by prior exposure to cefoxitin remained susceptibile to cefpirome.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects*; D005839:Gentamicins / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D011549:Pseudomonas / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D000097572:Cefpirome
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005839:Gentamicins; D010406:Penicillins; D000097572:Cefpirome