Differential efficacy of mebendazole and albendazole against Necator americanus but not for Trichuris trichiura infestations.
The effect of single oral doses of albendazole 600 mg and mebendazole 1 g given to 56 and 60 men, respectively, with T. trichiura and/or N. americanus infestation has been studied. Both albendazole and mebendazole cured more than 90% of T. trichiura infestations, but only albendazole (95%) and not mebendazole (21%) had a high cure rate for N. americanus infestations. Thus, albendazole is the preferred benzimidazole derivate for the mass treatment of subjects with T. trichiura and/or N. americanus infestations.
D015766:Albendazole; D001562:Benzimidazoles / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use*; D009332:Necatoriasis / Q000188:drug therapy*; D014257:Trichuriasis / Q000188:drug therapy*
D001562:Benzimidazoles; D008463:Mebendazole; D015766:Albendazole