A new human trophoblast antigen isolated from immune complexes derived from placental blood and membranes.
Immune complexes were prepared from human trophoblast membranes, placental blood serum, non-pregnant female serum and normal male serum by precipitation, gel filtration and affinity chromatography. The purified complexes were subjected to analysis by SDS-PAGE and one common antigenic species was identified. This antigen (mol. wt. 82.8 +/- 2.4 K) was designated the putative trophoblast antigen (TA) and shown to exhibit discrete antigenic homology with human immunoglobulin and HLA molecules.
D000328:Adult; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex / Q000032:analysis; D001769:Blood; D003429:Cross Reactions; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006680:HLA Antigens; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000302:isolation & purification*; D010920:Placenta / Q000276:immunology*; D011247:Pregnancy; D014327:Trophoblasts / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D006680:HLA Antigens; D008565:Membrane Proteins