Transport of p-aminohippurate in renal cortical slices of rats of different ages following treatment with thyroid hormones.
Following treatment with thyroid hormones PAH accumulation is increased in renal cortical slices of 5-, 10-, 20-, 30-, 50- and 105-day-old rats. Both thyroid hormones are more effective in young than in adult rats. A single dose of T3 or T4 (20 micrograms/100 g b.m.) administered 24 h before measurement is effective whereas acute effects of T3 or T4 on PAH transport could not be demonstrated. Treatment with thyroid hormones (20 micrograms/100 g b.m., 3 days, once a day) is without any influence on body mass; there is a tendency to an increase of kidney mass following treatment with T3 or T4. Simultaneous administration of an inhibitor of protein biosynthesis (neomycin, 1 or 5 mg/100 g b.m.) reduces the effect of T3 treatment. An additional low dose of T3, 24 h before measurement of PAH transport can restore the effect of T3 treatment which was performed 9 days before.
D000618:Aminohippuric Acids / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D004305:Dose-Response Relationship, Drug; D005260:Female; D007672:Kidney Cortex / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013963:Thyroid Hormones / Q000494:pharmacology*; D013974:Thyroxine / Q000494:pharmacology; D014284:Triiodothyronine / Q000494:pharmacology; D010130:p-Aminohippuric Acid / Q000378:metabolism*
D000618:Aminohippuric Acids; D013963:Thyroid Hormones; D014284:Triiodothyronine; D013974:Thyroxine; D010130:p-Aminohippuric Acid