Galactosemic nephropathy in the rat.
The effect of 30% galactose feeding on kidney function and structure was compared to the effect of streptozotocin-induced diabetes in the rat. In the galactose-fed rats there was increased urine volume (500%), creatinine clearance (40%), urinary albumin excretion (100%), urinary N-acetyl glucosaminidase (600%) and relative kidney weight (21%). These changes were similar to that observed in streptozotocin-induced diabetic animals. Galactitol in the kidney cortex of galactose-fed rats was increased 4 times similar to that observed for sorbitol in the streptozotocin-induced diabetic animals. Glycosylated hemoglobins were also increased in both galactose-fed animals and streptozotocin-treated animals. These data suggest that galactose feeding may be a useful model for investigating some aspects of diabetic nephropathy.
D000118:Acetylglucosaminidase / Q000652:urine; D000419:Albuminuria / Q000209:etiology; D000818:Animals; D003404:Creatinine / Q000652:urine; D003928:Diabetic Nephropathies / Q000503:physiopathology*; D004032:Diet; D004195:Disease Models, Animal; D005693:Galactosemias / Q000503:physiopathology*; D007668:Kidney / Q000473:pathology; D007672:Kidney Cortex / Q000378:metabolism; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains
D003404:Creatinine; D000118:Acetylglucosaminidase