Changes in seizure susceptibility in rats following chronic administration of pentylenetetrazol.
Repeated administration of pentylenetetrazol (PTZ) once every 48 h in behaviourally active threshold and suprathreshold doses induces a marked enhancement of seizure behaviour (kindling phenomenon). In contrast, PTZ in initially subconvulsive doses failed to elicit convulsions more complex than stage 1 seizures. With 40 mg/kg PTZ i.p. kindled rats show in the fully kindled state a marked shift of the dose-response curve for PTZ-seizures to the left. The mean stage 4 dose of PTZ is 40 mg/kg in kindled and 75 mg/kg in non-kindled rats.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007696:Kindling, Neurologic / Q000187:drug effects*; D010433:Pentylenetetrazole / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced*
D010433:Pentylenetetrazole