Lyme meningoencephalitis: report of a severe, penicillin-resistant case.
Although Lyme disease frequently attacks the central nervous system, this involvement is rarely severe, and high-dose intravenous penicillin usually is adequate treatment. The patient we describe developed severe Lyme meningoencephalitis despite receiving a full course of penicillin, and his condition continued to deteriorate after reinstitution of this treatment. Intravenous chloramphenicol was used successfully and resulted in a substantial improvement.
D000328:Adult; D002701:Chloramphenicol / Q000627:therapeutic use; D006801:Humans; D008193:Lyme Disease / Q000188:drug therapy*; D008297:Male; D008590:Meningoencephalitis / Q000188:drug therapy*; D010400:Penicillin G / Q000627:therapeutic use*; D010403:Penicillin Resistance
D002701:Chloramphenicol; D010400:Penicillin G