Cartilage proteoglycans in degenerative joint disease.
Cartilage content of proteoglycans decreases early in induced degenerative hip joint disease. Remaining molecules show structural changes indicating fragmentation. Fragments lost from the articular cartilage are released to the synovial fluid, where they can be quantified by enzyme linked immunosorbent assay. Their amounts are related to the activity of the disease process.
D000818:Animals; D002358:Cartilage, Articular / Q000378:metabolism*; D004195:Disease Models, Animal; D004285:Dogs; D010003:Osteoarthritis / Q000378:metabolism*; D011509:Proteoglycans / Q000378:metabolism*; D013582:Synovial Fluid / Q000378:metabolism
D011509:Proteoglycans