Can dietary fat influence hormone-induced growth responsiveness of the mammary gland?
Hormone-induced mammary gland growth responsiveness was examined in female Balb/c mice fed three different dietary levels (0, 5, and 20%) of fat (corn oil). Increasing the quantity of dietary fat enhanced hormone-induced mammary gland developmental growth processes both in vivo and in vitro. The effect of dietary fat was quite striking when comparing mice fed 0 and 5% fat diets and was less pronounced but still present when comparing mice fed 5 and 20% fat diets.
D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000254:growth & development; D051379:Mice; D008807:Mice, Inbred BALB C; D011374:Progesterone / Q000494:pharmacology*
D004041:Dietary Fats; D011374:Progesterone; D004958:Estradiol