title: Detection of propionic acid vapor by rats with lesions of olfactory bulb areas associated with high 2-DG uptake.
abstract: This study tested the functional significance of recent 2-deoxyglucose (2-DG) results demonstrating a discrete focus of activity in the olfactory bulb of rats exposed to the vapor of propionic acid. Rats with lesions that destroyed this area of the olfactory bulb performed as well as did sham operated and lesioned controls in detection of amyl acetate, butanol, geraniol, propionic acid, and on a test for propionic acid threshold. Our results demonstrate that an area of the olfactory bulb containing a major focus of metabolic activity induced by exposure to an odor can be removed without producing a deficit in the detection of that odor.
mesh_terms: D000818:Animals; D001345:Autoradiography; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D008297:Male; D009812:Odorants; D009830:Olfactory Bulb / Q000378:metabolism / Q000502:physiology*; D009833:Olfactory Pathways / Q000502:physiology; D011422:Propionates; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003837:Deoxy Sugars; D011422:Propionates; D003847:Deoxyglucose; C029658:propionic acid