The action of neutrophil elastase on intact and oxidized (met)-enkephalin-arg6-gly7-leu8 peptide.
Neutrophil elastase has been found to cleave met-enkephalin-arg6-gly7-leu8 between met5 and arg6 thereby releasing the active opiate met-enkephalin. Oxidized met-enkephalin octapeptide is not attacked by this enzyme. These data suggest a potential role for neutrophil proteinases and oxidases in the regulation of opiate production in tissues.
D004744:Enkephalin, Methionine / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000201:enzymology*; D010084:Oxidation-Reduction; D010196:Pancreatic Elastase / Q000378:metabolism*; D013997:Time Factors
D004744:Enkephalin, Methionine; D010196:Pancreatic Elastase