Post-transfusion purpura associated with anti-Baka and anti-PIA2 platelet antibodies and delayed haemolytic transfusion reaction.
The occurrence of post-transfusion purpura (PTP) in a 16-year-old girl with sickle/beta-thalassaemia is described. Clinically this was a typical case of PTP, but it was unusual serologically. Anti-Baka and anti-PIA2 platelet-specific antibodies were identified and the patient's platelets were typed as homozygous PIA1-positive and Baka-negative. The patient also developed red-cell, granulocyte and lymphocytotoxic antibodies in response to the blood transfusion and had a delayed haemolytic transfusion reaction.
D000293:Adolescent; D000906:Antibodies / Q000276:immunology*; D016824:Antigens, Human Platelet; D001792:Blood Platelets / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006098:Granulocytes / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis / Q000276:immunology; D006461:Hemolysis; D006801:Humans; D039661:Integrin beta3; D007519:Isoantigens / Q000276:immunology*; D011693:Purpura / Q000209:etiology / Q000276:immunology*; D013789:Thalassemia / Q000628:therapy; D065227:Transfusion Reaction
C044561:3a alloantigen, human; D000906:Antibodies; D016824:Antigens, Human Platelet; D006680:HLA Antigens; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007519:Isoantigens