7-Ethoxyresorufin deethylase (EROD) in human liver--the effect of alcoholic liver disease.
We have investigated the effect of alcoholic liver disease (ALD) on the metabolism of 7-ethoxycoumarin 0-deethylase in human liver microsomes. EROD activity was significantly reduced in tissue from ALD patients who smoked, compared to smoking controls. A similar trend was seen in non-smokers. These results have implications for the metabolism of environmental carcinogens.
D000328:Adult; D019363:Cytochrome P-450 CYP1A1; D004785:Environmental Pollutants / Q000378:metabolism; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008108:Liver Diseases, Alcoholic / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D010088:Oxidoreductases / Q000032:analysis*
D004785:Environmental Pollutants; D010088:Oxidoreductases; D019363:Cytochrome P-450 CYP1A1