Reversible adsorption (desorption) of aspirin from activated charcoal.
The potential desorption of aspirin from activated charcoal was investigated in eight patients in a randomized cross-over study. Despite prebinding of aspirin, systemic absorption did occur. Desorption from activated charcoal was characterized by a peak salicylate concentration that was 16% of control and a time to peak salicylate concentration that was delayed in the study group. Bioavailability of aspirin from activated charcoal described by area under the curve was 19% of control. Elimination half-lives were similar in both groups until 12 hours after ingestion, but after 12 hours the half-life of the study group was prolonged while salicylate concentrations were undetectable in the control group. Fifteen percent to 20% of aspirin prebound to charcoal may desorb leading to systemic absorption. Furthermore, release from activated charcoal is initially delayed then sustained through 30 hours.
D000327:Adsorption; D000328:Adult; D001241:Aspirin / Q000378:metabolism*; D001682:Biological Availability; D002606:Charcoal; D005260:Female; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D011897:Random Allocation; D013997:Time Factors
D002606:Charcoal; D001241:Aspirin