Inhibition of gastric secretion and stress-induced ulcers by intravenous Asu(1,7)eel-calcitonin independent of vasopressin.
The effects of different doses of Asu(1,7) eel-calcitonin, peripherally injected, on gastric secretion were studied in conscious Brattleboro rats, which are genetically deficient in vasopressin. Moreover, we evaluated the activity of this analogue on gastric ulcer formation by restraint stress. We found that 5 IU/kg Asu(1,7) eel-calcitonin decreased gastric secretion and inhibited the development of stress-induced ulcers in Brattleboro rats. These data suggest that vasopressin does not play a role in the gastrointestinal activity of Asu(1,7) eel-calcitonin.
D000818:Animals; D002116:Calcitonin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004524:Eels; D005753:Gastric Mucosa / Q000378:metabolism*; D006579:Heterozygote; D006720:Homozygote; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D011910:Rats, Brattleboro; D012016:Reference Values; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*; D014667:Vasopressins / Q000172:deficiency*
D014667:Vasopressins; D002116:Calcitonin; C012755:elcatonin