Effect of reserpine on the differentiation of the external granular layer of the cerebellum in the chick embryo.
In this work we analyse the effect produced by reserpine on the development of thickness and cell number in the external granular layer in the cerebellum of chick embryo. A striking 48-hour histogenetic delay is observed in the treated embryos relative to controls, as show by greater thickness and cell density of this layer in the former, as well as by retarded appearance of a typical radial morphological organization of the external granular layer.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002531:Cerebellum / Q000187:drug effects* / Q000196:embryology; D002642:Chick Embryo; D009024:Morphogenesis / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology*
D012110:Reserpine