[Complex formation of heparin with the inhibitor of non-enzymatic fibrinolysis isolated from the spleen].
Formation of complexes between heparin and protein inhibitor of non-enzymatic fibrinolysis, isolated from spleen tissue of healthy animals, was demonstrated by means of cross electrophoresis, UV- and IR-spectrophotometries. Suppression of the spleen inhibitor activity towards non-enzymatic fibrinolysis occurred via its complex-formation with heparin, where the inhibitor aminogroups reacted with sulfo- or carboxyl groups of heparin.
D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000032:analysis* / Q000494:pharmacology; D011506:Proteins / Q000032:analysis / Q000494:pharmacology; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013154:Spleen / Q000032:analysis*; D014020:Tissue Extracts / Q000032:analysis* / Q000494:pharmacology
D011506:Proteins; D014020:Tissue Extracts; D006493:Heparin
Kompleksobrazovanie geparina s ingibitorom nefermentativnogo fibrinoliza, vydelennym iz tkani selezenki.