The 3'-orf protein of human immunodeficiency virus 2 shows sequence homology with the bel3 gene of the human spumaretrovirus.
The primary amino acid sequence within a domain of 89 residues of the central part of the 3'-orf protein (p27 3'-orf) of human immunodeficiency virus (HIV-2) shares homology with the middle and carboxy-terminal portion of the bel3 gene product of human spumaretrovirus (HSRV). In addition, a limited region of the tat protein of HIV-2 but not HIV-1 shows a 28% degree of homology to the deduced protein sequence of the bel1 gene product of HSRV. Comparison between the viral sequences suggests that the 3'-orf and bel1 gene product of HSRV could serve similar functions to those in HIV-2.
D000595:Amino Acid Sequence; D005796:Genes; D006678:HIV / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D012190:Retroviridae / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics*
D014764:Viral Proteins