Anorectic effect of ephedrine.
1. Different doses of ephedrine (3.1-50 mg kg-1) were given intraperitoneally to rats and found to decrease food intake dose-dependently. 2. The anorectic effect of ephedrine was decreased by animal pretreatment with pimozide, but phenoxybenzamine, propranolol and methergoline did not decrease the response. 3. The results show that the anorexia produced by ephedrine may be due to indirect dopaminergic mechanism of the drug.
D000818:Animals; D001067:Appetite Depressants / Q000037:antagonists & inhibitors; D004809:Ephedrine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects; D008711:Metergoline / Q000494:pharmacology; D010868:Pimozide / Q000494:pharmacology; D051381:Rats; D013565:Sympatholytics / Q000494:pharmacology
D001067:Appetite Depressants; D013565:Sympatholytics; D008711:Metergoline; D010868:Pimozide; D004809:Ephedrine