title: Characterization of tannic acid metabolites formed in vitro by rat liver microsomes and assay of their carcinogenicity by the microsomal degranulation technique.
abstract: Tannic acid is converted to four metabolites on incubation with isolated rat liver microsomes. Bis-(3,4,5-trihydroxyphenyl)methanone (I); 3,4,6,7,9,10-hexahydroxy-2,11-epoxy-1,12-(epoxy-methano)-14H , 16H-benzo[b](1,4)benzodioxepino [3,2-g](1,4)benzodioxepin-14,16,17-trione (II) and 1,1,2-trimethyl-1-ethanyl-2-ylidene tris(3,4,5-trihydroxybenzoate) (III) were isolated from the post-microsomal supernatant of the incubate while 6,12,18,26,27,29,31,33-octahydroxy-22,22-dimethyl-2,8,14,20-tet raoxapentacyclo (22.2.2.2(4,7).2(10,13).2(16,19) tetratriaconta-4,6,10,12,16,18,24,26,27,29,31,33-dodecene-3, 9,15,21,23-pentone (IV) was found attached with the microsomal fraction. Metabolite (III) was found to be a potential carcinogen on the basis of microsomal degranulation technique.
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D055598:Chemical Phenomena; D002621:Chemistry; D047348:Hydrolyzable Tannins / Q000378:metabolism* / Q000633:toxicity; D013058:Mass Spectrometry; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D009152:Mutagenicity Tests; D051381:Rats; D013053:Spectrophotometry; D013634:Tannins / Q000378:metabolism*
chemical_list: D002273:Carcinogens; D047348:Hydrolyzable Tannins; D013634:Tannins