Effect of apomorphine on melatonin secretion in normal subjects.
There is some evidence in animals that dopamine (DA) affects melatonin secretion. The effect of apomorphine (Apo), a selective DA receptor agonist, and placebo on day-time melatonin secretion was studied in six normal men. Apo HCl in a dose (0.5 mg sc) which increased growth hormone secretion in all subjects had no effect on day-time melatonin concentrations in plasma. In keeping with other clinical studies these data suggest that melatonin secretion is not regulated by a DA mechanism in man.
D000293:Adolescent; D000328:Adult; D001058:Apomorphine / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D008297:Male; D008550:Melatonin / Q000097:blood*; D011954:Receptors, Dopamine / Q000187:drug effects
D011954:Receptors, Dopamine; D013006:Growth Hormone; D008550:Melatonin; D001058:Apomorphine