title: Mucosal pathology of an experimental otitis media with effusion after X-ray irradiation.
abstract: Ten guinea pigs were irradiated with 30 Gy of x-radiation. Five were killed on the eighth day after irradiation, and the remainder were killed at the sixteenth day after irradiation. At the time of death, examination was made of the ciliary activity and the fine structure of the middle ear mucosa. Serous effusion was found in each tympanic cavity of all animals. It was shown also that the guinea pig, when irradiated with 30 Gy of x-radiation, exhibits pathologic abnormalities similar to those in humans with otitis media with effusion: degeneration of cilia or ciliated cells and changes in the vascular system (capillary injury and increased capillary permeability). Functional examinations showed that x-ray irradiation has delayed effects on ciliary activity, and the effects are much greater at the sixteenth day than at the eighth day. We speculate that the accumulation of effusion can be, at least partially, a consequence of ciliary dysfunction. The induction of sterile effusion by the use of x-ray irradiation provides a unique animal model for chronic otitis media with effusion of the serous type.
mesh_terms: D000818:Animals; D002923:Cilia / Q000648:ultrastructure; D002925:Ciliary Motility Disorders / Q000473:pathology; D004195:Disease Models, Animal; D004432:Ear, Middle / Q000473:pathology / Q000528:radiation effects*; D006168:Guinea Pigs; D008854:Microscopy, Electron; D009092:Mucous Membrane / Q000473:pathology / Q000528:radiation effects; D010034:Otitis Media with Effusion / Q000473:pathology*; D011833:Radiation Injuries, Experimental / Q000473:pathology*