Dissolution of pancreatic stones by oral trimethadione in a dog experimental model.
Experiments were conducted to develop a dissolution therapy for human pancreatic calculi in a dog experimental model of pancreatic calculi surgically prepared. On plain x-ray films of the abdomen, pancreatic calculi appeared in 19 of 39 dogs within 12 mo after operation. The antiepileptic agent trimethadione was given orally to 13 dogs at a dose of 1.0-1.5 g daily. Pancreatic calculi disappeared in 13 of 15 observations. The scanning electron microscopy, the elemental analysis, and the powder x-ray diffractometry of pancreatic calculi in this model revealed that the calculi closely resembled human pancreatic calculi, consisting mainly of a calcite of calcium carbonate. There was no histologic finding suggesting drug toxicity in the liver, the kidney, and the blood. Pancreatic calculi in 6 control dogs without the treatment neither disappeared nor diminished spontaneously. The oral treatment with trimethadione may have potential for dissolving human pancreatic calculi.
D000284:Administration, Oral; D000818:Animals; D002137:Calculi / Q000628:therapy* / Q000648:ultrastructure; D004285:Dogs; D010080:Oxazoles / Q000627:therapeutic use*; D010182:Pancreatic Diseases / Q000628:therapy*; D013997:Time Factors; D014293:Trimethadione / Q000008:administration & dosage / Q000627:therapeutic use*
D010080:Oxazoles; D014293:Trimethadione