Distribution of trimipramine and its major metabolites in a fatal overdose case.
A fatality following ingestion of the tricyclic antidepressant trimipramine (Surmontil) is described. Quantitation was performed by high-performance liquid chromatography. Trimipramine and desmethyltrimipramine concentrations were 4.8 and 2.1 mg/L, respectively, in postmortem blood. The concentration of trimipramine, desmethyltrimipramine, and their respective 2-hydroxy metabolites were also measured in liver and urine. Analysis of gastric contents revealed a tricyclic antidepressant drug. These findings are compared to previously published reports of trimipramine-related fatalities.
D000328:Adult; D003984:Dibenzazepines / Q000378:metabolism*; D006801:Humans; D006900:Hydroxylation; D008297:Male; D014299:Trimipramine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000506:poisoning
D003984:Dibenzazepines; D014299:Trimipramine; C040606:desmethyltrimipramine