Vitamin E status in normocholesterolemic and hypercholesterolemic diabetic patients.
The close relationship between vitamin E, lipid and prostaglandin metabolism stresses the need for an accurate definition of the status of vitamin E in a diabetic population. Plasma vitamin E and plasma lipids were determined in 34 type I and 21 type II normocholesterolemic and in 7 hypercholesterolemic diabetics. They were also measured in 62 age- and sex-matched controls, 34 normocholesterolemic controls for type I, 21 normocholesterolemic controls for type II and 7 hypercholesterolemic individuals. Plasma vitamin E levels were not significantly different in type I and type II diabetics as compared to their respective control groups. Vitamin E levels were significantly increased (p less than 0.001) in hypercholesterolemic individuals, both in diabetics and in non-diabetics. The vitamin E/cholesterol ratio in these subjects was, however, not different from that of normocholesterolemic. Plasma vitamin E was correlated with plasma lipids, especially with total and LDL-cholesterol (p less than 0.001). Since vitamin E is mainly transported by plasma lipoproteins, these strong correlations suggest that changes in plasma vitamin E should be considered as an epiphenomenon of altered plasma transport capacity.
D000328:Adult; D002784:Cholesterol / Q000097:blood*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000150:complications; D008055:Lipids / Q000097:blood; D008297:Male; D014810:Vitamin E / Q000097:blood*
D008055:Lipids; D014810:Vitamin E; D002784:Cholesterol