title: [Gastric carcinoma with prominent reactive lymphoid hyperplasia; report of two cases with an immunohistological study].
abstract: An immunohistological study using a Leu 7 antibody, which is a marker for human NK and K cells, was carried out in two cases of gastric carcinomas with prominent reactive hyperplasia. The patients were a 72-year-old man and a 55-year-old man who had shown good postoperative courses in spite of the advanced stage of their tumors. There were many scattered Leu 7 positive cells in the lymphoid hyperplasia, predominantly in the germinal centers and the peri-follicles. The number of Leu 7 positive cells were even more pronounced in a patient whose condition was more advanced. These findings suggest that lymphoid hyperplasia, particularly with regard to the NK and K cell response, plays a significant role in the clinical benignity of the tumors.
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology*; D000368:Aged; D006801:Humans; D006965:Hyperplasia; D007694:Killer Cells, Natural / Q000276:immunology; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology*