title: [Synthesis and antiplatelet aggregating activity of several thiopyranylidene ketones and benzylidene indanones].
abstract: Some new aryl thiopyranylidene ketones and benzylidene indanones with various substituents on the benzene ring were synthesized and their inhibitory activities in vitro on human platelet aggregation were assayed. The 2-[(2,5-dimethoxyphenyl)methylene] indan-1-one is the most potent inhibitor (about seventeen times more active than aspirin, against arachidonic acid, and twenty four times against collagen).
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D066298:In Vitro Techniques; D007189:Indans / Q000138:chemical synthesis* / Q000494:pharmacology; D007192:Indenes / Q000138:chemical synthesis*; D007659:Ketones / Q000138:chemical synthesis / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011714:Pyrans / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D007189:Indans; D007192:Indenes; D007659:Ketones; D010975:Platelet Aggregation Inhibitors; D011714:Pyrans
vernacular_title: Synthèse et étude de l'activité antiagrégante plaquettaire de quelques thiopyrannylidène-cétones et benzylidène-indanones.