[Biochemico-pharmacological mechanisms and the relation between the anticalorigenic, hypothermic and antihypoxic effects of adenosine].
Administration of adenosine into mice induced a decrease in oxygen consumption (anticalorigenic effect), body temperature (hypothermal effect) and protected against acute hypoxia (antihypoxic action); all these effects are closely correlated. Isopropyl noradrenaline and theophylline prevented but propranolol and dipiridamol increased these effects of adenosine. Being administered into mice adenosine decreased both cAMP content (in skeletal muscles and kidney) and respiration in kidney homogenates. These adenosine effects appear to be realized via the following chain: A1-receptors----decrease in cellular cAMP content----inhibition of tissue oxygen consumption----development of anticalorigenic reactions----hypothermal effects----antihypoxic actions.
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004176:Dipyridamole / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D000860:Hypoxia / Q000517:prevention & control*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D051379:Mice; D010101:Oxygen Consumption / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D011983:Receptors, Purinergic / Q000187:drug effects* / Q000502:physiology; D013806:Theophylline / Q000494:pharmacology; D013997:Time Factors
D011983:Receptors, Purinergic; D004176:Dipyridamole; D011433:Propranolol; D013806:Theophylline; D000241:Adenosine; D007545:Isoproterenol
Issledovanie biokhimiko-farmakologicheskikh mekhanizmov i vzaimosviazi antikalorigennogo, gipotermicheskogo i antigipoksicheskogo éffektov adenozina.