title: Research and development on total artificial heart in University of Tokyo.
abstract: The research and development on the total artificial heart (TAH) in the University of Tokyo can be divided chronologically into the three stages, i.e., the first stage (1959-1970); trial and error stage to find appropriate hardwares, the second stage (1970-1985); software stage to find how to control pneumatic TAH and to manage the animals, and the third stage (1985- ); final goal to develop implantable TAH for animal and human. This paper reviews the process of research and development in each stage.
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006354:Heart, Artificial; D006801:Humans; D011474:Prosthesis Design; D012106:Research; D014041:Tokyo; D014495:Universities