title: Long-term effects of a linoleic acid-enriched diet, changes in body weight and alcohol consumption on serum total and HDL-cholesterol.
abstract: Investigations on diet, body weight, and lipoproteins were carried out in 28 patients with stable angina pectoris. They consumed a linoleic acid-enriched diet (P/S ratio = 2) for a period of 2 years. The total fat content remained constant before and during intervention, contributing 34% to energy intake. During intervention serum total cholesterol and the total/HDL cholesterol ratio decreased significantly, but HDL cholesterol did not change. Changes in body weight were significantly inversely related to changes in HDL cholesterol and positively to the total/HDL cholesterol ratio. Changes in alcohol intake were significantly positively related to both total and HDL cholesterol but unrelated to the total/HDL cholesterol ratio. From the results of this long-term study it can be concluded that a moderate fat diet with a P/S ratio of 2 can lower total cholesterol effectively without affecting HDL cholesterol.
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D000787:Angina Pectoris / Q000097:blood / Q000473:pathology; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D002788:Cholesterol Esters / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D004032:Diet; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D002788:Cholesterol Esters; D008076:Cholesterol, HDL; D005227:Fatty Acids; D008041:Linoleic Acids; D002784:Cholesterol; D019787:Linoleic Acid