Kinetic resolution in the oxidation of iminium ion to lactam catalysed by aldehyde oxidase.
A rabbit liver enzyme preparation oxidised racemic iminium ions 1 and 2 to optically active lactams 3 and 4 with enantiomer ratios ER/S = 5.5 and 0.14, respectively.
D042931:Aldehyde Oxidase; D000445:Aldehyde Oxidoreductases / Q000378:metabolism*; D000818:Animals; D002412:Cations; D007097:Imines / Q000378:metabolism*; D007202:Indicators and Reagents; D007700:Kinetics; D007769:Lactams; D008099:Liver / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D011760:Pyrrolidinones / Q000138:chemical synthesis; D011817:Rabbits; D013237:Stereoisomerism
D002412:Cations; D007097:Imines; D007202:Indicators and Reagents; D007769:Lactams; D011760:Pyrrolidinones; D000445:Aldehyde Oxidoreductases; D042931:Aldehyde Oxidase