Autoantibodies and antibodies to microorganisms in rheumatoid arthritis: comparison of histocompatible siblings.
A selection of antibodies to microorganisms were assayed on sera from a group of 12 pairs of HLA identical rheumatoid arthritis (RA) discordant siblings. Our results did not show any consistent quantitative or qualitative differences between RA and non-RA. However, autoantibodies were commoner and of higher titer in the subjects with RA. There was a difference in the antibodies to intrinsic antigens in RA which was not reflected in the antibodies to extrinsic antigens.
D000907:Antibodies, Bacterial / Q000032:analysis*; D000914:Antibodies, Viral / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D006680:HLA Antigens / Q000032:analysis; D006801:Humans
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D001323:Autoantibodies; D006680:HLA Antigens