title: Cystic fibrosis: a casualty of "detoxification"?
abstract: It is proposed that excessive and/or aberrant function of cytochromes P450, due to a combination of genetic and environmental influences, is the basic defect in cystic fibrosis. Organs that are involved in oxidative detoxification reactions in foetal life are thus at risk: tissue damage is initiated by excessive production of oxygen free radicals which deplete cellular antioxidants and provoke the secretion of mucus.
mesh_terms: D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000209:etiology* / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006801:Humans; D010195:Pancreatitis / Q000150:complications
chemical_list: D003577:Cytochrome P-450 Enzyme System