Performance and biocompatibility of a new hemodialysis membrane.
Performance studies and investigations of the biocompatibility of a new hemodialysis membrane were conducted in patients being chronically hemodialyzed. The investigated polycarbonate membrane revealed a very satisfying performance with regard to clearance values and the ultrafiltration rate. The biocompatibility studies showed a significant leukopenia and an increase of C5a, platelet factor 4 and granulocyte elastase. Thrombocytes and C3d remained unchanged. Long-term studies have to confirm whether or not the new membrane is more biocompatible, a suggestion which could be advanced, as no febrile episodes were observed during any treatment, a finding which is not typical for Cuprophan hemodialysis.
D001672:Biocompatible Materials; D001794:Blood Pressure; D001831:Body Temperature; D003167:Complement Activation; D003182:Complement C5 / Q000032:analysis; D015936:Complement C5a; D003404:Creatinine / Q000097:blood; D003738:Dental Cements; D006098:Granulocytes / Q000201:enzymology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D007958:Leukocyte Count; D010196:Pancreatic Elastase / Q000097:blood; D010710:Phosphates / Q000097:blood; D010976:Platelet Count; D011076:Polycarboxylate Cement; D011674:Pulse; D006435:Renal Dialysis / Q000379:methods*; D014508:Urea / Q000097:blood
D001672:Biocompatible Materials; D003182:Complement C5; D003738:Dental Cements; D010710:Phosphates; D011076:Polycarboxylate Cement; C005506:polycarbonate; D015936:Complement C5a; D014508:Urea; D003404:Creatinine; D010196:Pancreatic Elastase