title: Pancreatic responses to endogenous and exogenous gastrin in the dog.
abstract: Serum gastrin and pancreatic secretion were measured in conscious Thomas fistula dogs during infusion of increasing doses of porcine gastrin, against a background of secretin. Dose-response relationships were calculated for the effects of gastrin on pancreatic secretion. Gastrin release was also measured after a test meal and after vagal stimulation with 2-deoxyglucose. Peak serum gastrin levels after these stimuli were less than the serum gastrin level associated with the minimal effective dose of gastrin. From the dose-response relationship of serum gastrin and pancreatic protein output, it was possible to calculate the protein output corresponding to the peak gastrin levels after 2-deoxyglucose or a meal. These were equivalent to 20-30% of the observed protein response to these stimuli. We conclude that gastrin plays at most a small part in the stimulation of pancreatic secretion after a meal and in response to 2-deoxyglucose. We also found that truncal vagotomy reduces pancreatic sensitivity to gastrin.
mesh_terms: D000818:Animals; D003847:Deoxyglucose / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005755:Gastrins / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010189:Pancreatic Juice / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D005755:Gastrins; D011506:Proteins; D003847:Deoxyglucose