title: Influence of 5-hydroxytryptamine on the combination effect of lonidamine or gossypol and hyperthermia on Ehrlich tumour in vivo.
abstract: An experiment was conducted using lonidamine and gossypol against Ehrlich tumour in the foot pad of CD-1 mice. These compounds alone were mild antitumour agents, but their cytotoxicity increased when they were combined with hyperthermia. The antitumor effect was further increased by 5-hydroxytryptamine, particularly when combined with lonidamine.
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000628:therapy*; D003131:Combined Modality Therapy; D006072:Gossypol / Q000008:administration & dosage*; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D007191:Indazoles / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000008:administration & dosage*; D012701:Serotonin / Q000494:pharmacology*
chemical_list: D007191:Indazoles; D011720:Pyrazoles; D012701:Serotonin; D006072:Gossypol; C016371:lonidamine