Multilocular renal cyst. A hamartoma with potential for neoplastic transformation?
Multilocular renal cyst is a pathologically distinctive lesion of uncertain pathogenesis that usually presents as a large abdominal mass in male infants or middle-aged women. We performed detailed light and electron microscopic studies of three nephrectomy specimens that contained multilocular cysts and attempted to correlate their morphology with various theories of pathogenesis. In one of our cases, a microscopic focus of clear cells that resembled renal cell adenocarcinoma was observed in the wall of one locule. Although such a finding has been reported previously, the lack of well-documented cases with metastases suggests that the prognosis for patients with this lesion remains uniformly excellent.
D000328:Adult; D002292:Carcinoma, Renal Cell / Q000473:pathology; D005260:Female; D006222:Hamartoma / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D052177:Kidney Diseases, Cystic / Q000473:pathology*; D007680:Kidney Neoplasms / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D011379:Prognosis