Transgenic progeny inherit tissue-specific expression of rat elastase I genes.
Six different lines of transgenic mice bearing rat elastase I genes stably inherit both the high-level pancreatic expression and low-level nonpancreatic expression characteristic of each original founding mouse. The high pancreatic expression of the introduced rat genes is transcriptionally determined. In response to high rat elastase I mRNA content in the pancreas, rat elastase I protein is synthesized and secreted at high levels. The stable inheritance of expression of the foreign rat elastase I genes in transgenic mice allows the development of animal lines that synthesize and secrete high levels of foreign protein by the pancreas.
D000818:Animals; D005786:Gene Expression Regulation; D007526:Isoelectric Point; D051379:Mice; D008970:Molecular Weight; D010179:Pancreas / Q000502:physiology*; D010196:Pancreatic Elastase / Q000235:genetics*; D051381:Rats; D014018:Tissue Distribution; D014158:Transcription, Genetic; D014162:Transfection
D010196:Pancreatic Elastase