The effect of L-2-oxothiazolidine on glutathione levels in cultured mammalian cells.
Chinese hamster ovary cells were cultured with increasing concentrations (7 X 10(-8) M-7 X 10(-2) M) of L-2-oxothiazolidine in an attempt to increase intracellular glutathione levels in these multiply-passaged mammalian cells. In a series of 7 Expts., intracellular glutathione levels increased significantly at the highest concentrations tested and were protective against oxygen radical-induced genetic toxicity.
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism*; D010100:Oxygen / Q000633:toxicity; D011761:Pyrrolidonecarboxylic Acid; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013844:Thiazoles / Q000494:pharmacology*; D053778:Thiazolidines
D005609:Free Radicals; D013844:Thiazoles; D053778:Thiazolidines; D005978:Glutathione; D010100:Oxygen; D011761:Pyrrolidonecarboxylic Acid; C029536:2-oxothiazolidine-4-carboxylic acid