Growth of spontaneous BALB/c tumours excised from and retransplanted to autochtonous hosts.
Tumours of aged Balb/c mice developed without any conscious experimental interference were excised and retransplanted to the autochtonous hosts. The autotransplantation resulted in tumour take after a prolonged period of latency or in no take for an extended period of observation (more than 80 days) in 6 out of 19 cases. This can be regarded as a sign of antitumoural resistance, although it seems to be ineffective against development of recidives and metastases or second tumours. The sensitivity of the autotransplantation method in detecting antitumoural resistance was compared to that of the transplantation-excision-retransplantation assay using a benzpyrene induced Balb/c fibrosarcoma; the autotransplantation method proved to be less sensitive. According to these data the existence of some kind of resistance against spontaneous tumour cells cannot be excluded.
D000818:Animals; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000276:immunology*; D014182:Transplantation, Autologous