The effect of pyridoxine supplementation on plasma pyridoxal-5'-phosphate levels in children with the nephrotic syndrome.
Nineteen children with low plasma pyridoxal-5'-phosphate (PLP) levels in the nephrotic syndrome due to a variety of histological entities were successfully supplemented with oral pyridoxine hydrochloride. A dose of approximately 2 mg/kg/day of pyridoxine hydrochloride was found to effect adequate plasma PLP levels in most cases. A significant (p less than 0.001) positive correlation (r = 0.83) was found between plasma albumin and PLP levels prior to supplementation and after supplementation both in relapse and remission. Although vitamin B6 repletion led to no demonstrable effect on the clinical course of the syndrome, in view of the possible role which vitamin B6 deficiency may play in defective immune response and thromboembolic phenomena, both being known complications of the nephrotic syndrome, the administration of vitamin B6 supplements is recommended in the active disease state.
D000284:Administration, Oral; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood / Q000188:drug therapy*; D011732:Pyridoxal Phosphate / Q000097:blood*; D011736:Pyridoxine / Q000008:administration & dosage / Q000494:pharmacology*; D012709:Serum Albumin / Q000032:analysis
D012709:Serum Albumin; D011732:Pyridoxal Phosphate; D011736:Pyridoxine