title: Analysis of formulations containing pralidoxime mesylate by liquid chromatography.
abstract: An improved liquid chromatography procedure has been devised for the analysis of pralidoxime mesylate (P2S) and its degradation products in solution. An additional degradation product, 2-hydroxyaminoiminomethyl-1-methylpyridinium, has been positively identified and its route of formation and that of another recently identified product, 2-hydroxymethyl-1-methylpyridinium, has been established. Previous problems with the chromatography of 2-formyl-1-methylpyridinium have been resolved and the new method will resolve P2S and eight of its degradation products.
mesh_terms: D000438:Alcohols; D002853:Chromatography, Liquid; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D011220:Pralidoxime Compounds / Q000032:analysis*; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000438:Alcohols; D007202:Indicators and Reagents; D011220:Pralidoxime Compounds; D012997:Solvents; C028797:pralidoxime