Regeneration of the sciatic nerve in mice and rats exposed to trichloroethylene.
The effects of trichloroethylene (TCE) on regeneration of the sciatic nerve after a crush lesion was tested in mice and rats. A lesion was made on nerves in unexposed animals and in animals pre-exposed to TCE for 20 days. Experimental animals were then exposed to TCE for an additional 4 days. Exposures were continuous at 150 or 300 ppm. Regeneration was measured by pinching the outgrowing nerve fibers. Regeneration was retarded in the TCE-exposed animals compared to the air-exposed controls. Mice were more sensitive to TCE exposure than rats. Liver weight increased in TCE-exposed mice but there was no correlation between this effect and that on nerve regeneration.
D000280:Administration, Inhalation; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D009416:Nerve Regeneration / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects / Q000293:injuries; D014241:Trichloroethylene / Q000494:pharmacology / Q000633:toxicity*
D014241:Trichloroethylene