[Radioprotective activity of aminoarylthiazoles and various mechanisms of action].
The amino group is shown to be the reaction center that is primarily responsible for the radioprotective effect of the thiazoles under study. A phenyl residue also contributes to the radioprotective effect. The influence of thiazoles on DNA biosynthesis on radiosensitive tissues plays an important role in the biochemical mechanism of their radioprotective action.
D000814:Aniline Compounds / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D004247:DNA / Q000096:biosynthesis; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000494:pharmacology* / Q000633:toxicity
D000814:Aniline Compounds; D011837:Radiation-Protective Agents; D013844:Thiazoles; D004247:DNA
Radiozashchitnaia aktivnost' aminoariltiazolov i nekotorye mekhanizmy ikh deĭstviia.