[Effect of polyunsaturated fatty acids on the functional properties of the thrombocytes and on lipid peroxidation in ischemic heart disease patients].
Platelet function, lipid peroxidation, and levels of cholesterol, triglycerides, high density lipoprotein (HDLP) cholesterol and PGE1 and PGF2 alpha were assessed before and after 28-day administration of polyunsaturated fatty acids (PUFA), contained in olive, corn and cod oil, in 80 coronary patients. The use of PUFA is shown to have a favorable effect on platelet function, decreasing aggregation and increasing disaggregation of platelets. This effect may be due to increased PGE1, producing an antiaggregation effect, while cod oil may also increase HDLP. Additional administration of vitamin E and HDLP prevents unfavorable effects of increased lipid peroxidation.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D002908:Chronic Disease; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy; D010084:Oxidation-Reduction / Q000187:drug effects; D005082:Physical Exertion; D010974:Platelet Aggregation / Q000187:drug effects; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use
D005231:Fatty Acids, Unsaturated; D008054:Lipid Peroxides; D014810:Vitamin E; D000244:Adenosine Diphosphate
Vliianie polinenasyshchennykh zhirnykh kislot na funktsional'nye svoĭstva trombotsitov i perekisnoe okislenie lipidov u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.