Proliferation activity of stromal stem cells (CFU-f) from hemopoietic organs of pre- and postnatal mice.
Stromal stem cells (CFU-f assay) from hemopoietic organs of fetuses, in contrast to adult animals, exhibit a high proliferation activity. This implies that these CFU-f are radiosensitive and potential target cells after radioactive contamination of fetuses. Furthermore, the percentage of CFU-f in DNA synthesis is correlated with the hemopoietic activity in liver, spleen, and bone marrow. As hemopoiesis starts, high numbers of CFU-f are in S phase. In fetal liver, spleen, and bone marrow, values of 70, 43, and 58%, respectively, are reached. As hemopoietic activity decreases in liver and stabilizes in spleen and bone marrow, mitotic activity of these stromal stem cells becomes undetectable.
D000818:Animals; D000831:Animals, Newborn; D001853:Bone Marrow / Q000196:embryology; D001854:Bone Marrow Cells; D002455:Cell Division; D003114:Colony-Forming Units Assay; D005865:Gestational Age; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006413:Hematopoietic System / Q000166:cytology / Q000196:embryology*; D008099:Liver / Q000166:cytology / Q000196:embryology; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology / Q000196:embryology; D013936:Thymidine
D013936:Thymidine