Acute effects of isopropyl alcohol exposure on the middle ear mucosa.
Guinea pigs were exposed to 400 ppm or 5500 ppm of isopropyl alcohol (IPA) for 24 successive hours, and then middle ear mucosal samples in both proximal and distal sites to the eustachian tube were obtained for functional and morphological examinations. The ciliary activity was examined according to the photoelectric method of Ohashi and Nakai. The morphology of the middle ear lining was examined by transmission electron microscopy. The results showed that IPA at the allowable level of 400 ppm has an acute effect on the mucociliary system of the middle ear mucosa. Recovery from damage occurs within two weeks. At higher levels of exposure to IPA (more than 10 times the allowable level) moderate deterioration of the ciliary activity and severe damage of epithelial cells were observed and recovery within two weeks was not seen. It is concluded that IPA at the allowable level of 400 ppm does not cause significant middle ear disorders, but workers exposed to higher levels of IPA should be given careful otolaryngological examinations and follow-up observations.
D000433:1-Propanol / Q000633:toxicity*; D000395:Air Pollutants, Occupational / Q000633:toxicity; D000818:Animals; D002923:Cilia / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D004432:Ear, Middle / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D006168:Guinea Pigs; D008297:Male; D008854:Microscopy, Electron; D009092:Mucous Membrane / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D014835:Volatilization
D000395:Air Pollutants, Occupational; D000433:1-Propanol