[Possibility of decreasing the anticomplement activity of human immunoglobulin preparations via chemical modification].
The physicochemical and immunological properties of the experimental batches of the preparations of placental immunoglobulin, obtained by some methods of chemical modification of the molecule of IgG, have been studied. The possibility of abolishing the anticomplement properties of the preparations treated with sulfitolytic agents manufactured in the USSR has been shown. The optimum conditions permitting the production of the preparation with faintly pronounced anticomplement properties and the full monomer structure of its molecule have been established.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003169:Complement Inactivator Proteins; D003300:Copper / Q000494:pharmacology; D019327:Copper Sulfate; D006801:Humans; D007120:Immunochemistry; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology*; D007202:Indicators and Reagents; D013329:Structure-Activity Relationship; D013447:Sulfites / Q000494:pharmacology; D013776:Tetrathionic Acid / Q000494:pharmacology
D003169:Complement Inactivator Proteins; C021306:IgG, sulfonated; D007074:Immunoglobulin G; D007202:Indicators and Reagents; D013447:Sulfites; D003300:Copper; D013776:Tetrathionic Acid; D019327:Copper Sulfate; C025026:sodium sulfite
Vozmozhnost' snizheniia antikomplementarnoĭ aktivnosti preparatov immunoglobulina cheloveka s pomoshch'iu khimicheskoĭ modifikatsii.