Post-antibiotic effect and killing activity of ciprofloxacin against Staphylococcus aureus.
The effect of ciprofloxacin on eight strains of Staphylococcus aureus were examined. A post-antibiotic effect was observed in all strains, varying between 1.65 and 2.75 hours, with concentration of ciprofloxacin at 5 times the Minimum Inhibitory Concentration (MIC) exposed for 1 hour. Killing-kinetic studies at 5 times the MIC showed a decrease in the numbers of organisms by approximately 2.1 log10 after 6 hours, independent of the growth phase. A significantly increased susceptibility of S. aureus to the bactericidal activity of ciprofloxacin during recovery from the PAE-phase was demonstrated.
D002939:Ciprofloxacin / Q000008:administration & dosage*; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013997:Time Factors
D002939:Ciprofloxacin