Management of inflammation: the parametrical system, its practical and methodological position.
Since individual cases of inflammation differ one from another, and it is necessary to distinguish between adequate and inadequate inflammatory responses, the proper Management of Inflammation demands the simultaneous assessment of the various component processes. The parameters chosen for such diagnosis should be of broad specificity and show unequivocal and consistent changes wherever the inflammatory response is inadequate. Our long-term studies of carrageenin-induced inflammation in variously conditioned rats have led to a singling out of a set of parameters which satisfy the above three conditions, some fully and some partly: lipid peroxide, proamidase and lysosomal enzymes in exudate, sialoglycoproteins in serum and alkaline phosphatase, elastase in granuloma pouch tissue. Use of this system affords a broad reliable observation of inflammatory processes which an interpretation of isolated components alone could not provide, and determines the position and significance of other components in the inflammatory system. Moreover, it permits the discovery of correlations which would hardly be realized if single mechanisms were considered, and helps to form new hypotheses and to outline fields for further study.
D000469:Alkaline Phosphatase / Q000502:physiology; D000581:Amidohydrolases / Q000502:physiology; D000818:Animals; D001777:Blood Coagulation; D002351:Carrageenan; D004195:Disease Models, Animal; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D008054:Lipid Peroxides / Q000502:physiology; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D019158:N-Acetylneuraminic Acid; D010196:Pancreatic Elastase / Q000502:physiology; D010587:Phagocytosis; D051381:Rats; D011919:Rats, Inbred Strains; D012794:Sialic Acids / Q000502:physiology
D008054:Lipid Peroxides; D012794:Sialic Acids; D002351:Carrageenan; D000469:Alkaline Phosphatase; D010196:Pancreatic Elastase; D000581:Amidohydrolases; D019158:N-Acetylneuraminic Acid