title: Effects of hormone deprivation on the karyometric development of the medial and lateral preoptic area of the male mouse. I. Neonatal castration.
abstract: We have analysed the karyometric development of the nuclear neuronal sizes in the medial and lateral preoptic area of male albino mice castrated within 24 hours of birth. We have analysed six different age groups of animals: 10th, 20th, 35th, 45th, 55th and 85th postnatal day, and we have compared our results to those of a control group of male mice. Both hypothalamic areas respond to neonatal castration showing lower values of the nuclear sizes than those of the control group. The reaction of these areas to gonadal hormone deprivation at birth is more striking than that obtained after prepuberal castration of the animals, studied in a previous report. Neonatal gonadal hormone deprivation also produces changes of the nuclear shape of the nuclei towards sphericity.
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D002369:Castration; D002467:Cell Nucleus / Q000502:physiology*; D007620:Karyometry; D008297:Male; D051379:Mice; D011301:Preoptic Area / Q000166:cytology / Q000254:growth & development*; D013735:Testicular Hormones / Q000502:physiology*
chemical_list: D013735:Testicular Hormones