Identification of two glucuronide metabolites of doxylamine via thermospray/mass spectrometry and thermospray/mass spectrometry/mass spectrometry.
Analysis of a high-pressure liquid chromatography fraction containing two urinary glucuronide metabolites of doxylamine by thermospray mass spectrometry (TSP/MS) provided [MH]+ ions for each metabolite. TSP/MS/MS of the [MH]+ ions provided a fragment ion characteristic of these metabolites. The results demonstrate the utility of TSP/MS analysis for biologically derived glucuronide metabolites.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004319:Doxylamine / Q000378:metabolism*; D005965:Glucuronates / Q000032:analysis*; D008297:Male; D013058:Mass Spectrometry; D008722:Methods; D011725:Pyridines / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344
D005965:Glucuronates; D011725:Pyridines; D004319:Doxylamine