Urinary trace amine excretion and platelet monoamine oxidase activity in schizophrenia.
The relationship between subtypes of schizophrenia classified by ICD-9 and 24-hour urinary beta-phenylethylamine (PEA) and phenylacetic acid (PAA) excretion has been studied. Schizophrenia was divided into two types: paranoid and nonparanoid. Increased urinary PEA excretion was found in paranoid schizophrenics, but urinary PAA excretion did not show any significant difference between schizophrenics and normal subjects. A relationship between platelet monoamine oxidase (MAO) activity and urinary PEA excretion was found. These findings offer some indication that PEA may play a role in the pathogenesis of schizophrenia.
D000328:Adult; D001792:Blood Platelets / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D010627:Phenethylamines / Q000652:urine*; D010648:Phenylacetates / Q000652:urine*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000201:enzymology*; D012563:Schizophrenia, Paranoid / Q000201:enzymology; D012565:Schizophrenic Psychology
D010627:Phenethylamines; D010648:Phenylacetates; C029261:phenethylamine; D008995:Monoamine Oxidase; C025136:phenylacetic acid