Corresponding spatial gradients of TOP molecules in the developing retina and optic tectum.
The topographic map of cell position in the avian retina is inverted in its projection to the optic tectum. Dorsal retinal ganglion cell axons project to ventral tectum, and ventral retinal ganglion cells project to dorsal tectum. Topographic gradients of toponymic (TOP) cell surface molecules along the dorsoventral axes of retina and tectum also are inverted. TOP molecules are most abundant in dorsal retina and ventral tectum and least abundant in ventral retina and dorsal tectum during the period of initial retinal-tectal interaction. Thus, TOP molecules may be involved in orienting the retinotectal map.
D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis; D002642:Chick Embryo; D011863:Radioimmunoassay; D012160:Retina / Q000166:cytology / Q000196:embryology*; D012165:Retinal Ganglion Cells / Q000166:cytology; D013477:Superior Colliculi / Q000166:cytology / Q000196:embryology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface