[Characteristics of prostanoid synthesis in patients with duodenal ulcer complicated by a history of hemorrhage].
After inhibition of the cyclooxygenase pathway of arachidonic acid metabolism by means of indomethacin or aspirin the initially low aggregation activity of thrombocytes was not distinctly decreased, the antiaggregatory function of the blood vessels endothelium was not suppressed, secretion of bicarbonates was 1.5-2-fold less distinctly inhibited as well as secretion of acid and pepsin with gastric juice was less distinctly stimulated in patients with duodenal ulcer accompanied by hemorrhage as compared with healthy persons or the patients with non-complicated form of duodenal ulcer. At the same time, inhibition of bicarbonate secretion correlated with the antiaggregative activity of the blood vessel wall. The data obtained suggest that cyclooxygenase pathway of prostaglandin synthesis was distinctly impaired in the patients with hemorrhagic complications. Alterations in hemostatic and secretory parameters, caused by indomethacin or aspirin, should be considered in prognostic evaluation of the patients with duodenal ulcer, which had an increased risk of hemorrhagic complications.
D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000494:pharmacology; D004381:Duodenal Ulcer / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000097:blood* / Q000209:etiology; D010974:Platelet Aggregation / Q000187:drug effects*; D011453:Prostaglandins / Q000096:biosynthesis* / Q000097:blood
D011453:Prostaglandins; D001241:Aspirin; D007213:Indomethacin
Osobennosti sinteza prostanoidov u bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki s gemorragicheskimi oslozhneniiami v anamneze.