title: Regulation of dopamine function in the prefrontal cortex of the rat by the thalamic mediodorsal nucleus.
abstract: Dopamine (DA) utilisation has been assessed in the medial bank of the prefrontal cortex (FCx) and the agranular insular cortex (AgCx) of the rat in response to unilateral manipulations of the thalamic mediodorsal nucleus (MD). The ratios of 3,4-dihydroxyphenylacetic acid (DOPAC):DA and 4-hydroxy-3-methoxyphenylacetic acid (homovanillic acid, HVA):DA are used as indices of DA utilisation and were shown to increase in the ipsilateral FCx following electrical stimulation of lateral MD. A similar response was observed 1 hr after an infusion of the excitotoxin sodium ibotenate into lateral MD, although in this case the increase in DA utilisation in FCx was bilateral. Longer periods of recovery after ibotenate treatment (2 day and 1 week) produced DA utilisation ratios that had returned to near control values and by 1 week a significant decrease was detected in HVA:DA of the contralateral FCx. All treatments had little effect on DA utilisation in AgCx, although there was a tendency towards enhanced ratios after electrical stimulation and short-term ibotenate injection. These findings suggest that stimulation of MD neurones may tend to activate the DA system in their convergent terminal regions of cortex. It is argued that these influences result from interactions at the level of the DA terminal rather than at the cell bodies of mesocortical DA neurones.
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D005625:Frontal Lobe / Q000378:metabolism* / Q000502:physiology; D006719:Homovanillic Acid / Q000378:metabolism; D007051:Ibotenic Acid; D008297:Male; D011846:Radio Waves; D051381:Rats; D011919:Rats, Inbred Strains; D013787:Thalamic Nuclei / Q000473:pathology / Q000502:physiology*; D013997:Time Factors
chemical_list: D015102:3,4-Dihydroxyphenylacetic Acid; D007051:Ibotenic Acid; D004298:Dopamine; D006719:Homovanillic Acid