A model of hemopoietic stress in a lactate dehydrogenase mouse mutant with hemolytic anemia.
A codominantly inherited mutation of the lactate dehydrogenase (LDH) in the C3H mouse causes a severe hemolytic anemia in homozygous mutants, whereas viability and fertility are close to normal. Investigation of multipotent hemopoietic stem cells (CFU-S), myeloid (GM-CFC) and erythroid progenitors (BFU-E, CFU-E) in femur and spleen indicates a general shift from bone marrow to splenic hemopoiesis. In terms of total body hemopoiesis, however, the BFU-E pool is 1.4- and the CFU-E pool 19-fold enlarged, whereas CFU-S and GM-CFC show little or no deviation from normal. It is concluded that this mouse mutant is an appropriate model of long-term hemopoietic stress showing that compensation in this severe hemolytic anemia is achieved primarily by an increase of the number of the most mature erythroid progenitors.
D000743:Anemia, Hemolytic / Q000503:physiopathology*; D000818:Animals; D002452:Cell Count; D005269:Femur / Q000166:cytology; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells; D006720:Homozygote; D007770:L-Lactate Dehydrogenase / Q000235:genetics*; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics*; D009154:Mutation; D013154:Spleen / Q000166:cytology; D013234:Stem Cells
D007770:L-Lactate Dehydrogenase