High production of type VI collagen in multiple fibromatosis with multiple articular dysplasia.
A patient with multiple fibromatosis occurring at the sites of multiple cartilagenous dysplasia was described. Collagen types solubilized with pepsin from the fibromatous tissue were fractionated by a different salt concentration and analyzed by SDS-polyacrylamide gel electrophoresis, which indicated that the tissue produces predominantly "short-chain" collagen. Western blotting of the subunits indicated a cross reaction with antisera of the type VI collagen. The results of rotatory shadowing electron microscopy confirmed the characteristic short-chain structure.
D000596:Amino Acids / Q000032:analysis; D003094:Collagen / Q000096:biosynthesis*; D005350:Fibroma / Q000378:metabolism*; D006801:Humans; D007592:Joint Diseases / Q000378:metabolism*; D046911:Macromolecular Substances; D008970:Molecular Weight; D011487:Protein Conformation
D000596:Amino Acids; D046911:Macromolecular Substances; D003094:Collagen