Identification of HLA-B44 subtypes associated with extended MHC haplotypes.
The HLA class I antigen B44 is found in each of two different extended major histocompatibility haplotypes (allele combinations of HLA-B, HLA-DR, and complement genes BF, C2, C4A, and C4B in linkage disequilibrium). Using isoelectric focusing, two variants of HLA-B44 were identified. The basic variant was found in all cell lines with the extended haplotype HLA-B44, DR7, FC31, and the acidic variant in all cell lines with the extended haplotype HLA-B44, DR4, SC30. The occurrence of each antigen variant with a unique extended haplotype explains previous observations concerning the nonrandom association of B44 variants with DR antigens.
D002460:Cell Line; D014644:Genetic Variation; D006680:HLA Antigens / Q000145:classification* / Q000235:genetics; D015235:HLA-B Antigens; D059948:HLA-B44 Antigen; D006239:Haplotypes; D006801:Humans; D007525:Isoelectric Focusing; D008285:Major Histocompatibility Complex
D006680:HLA Antigens; D015235:HLA-B Antigens; D059948:HLA-B44 Antigen