Pulsed Doppler ultrasound compared with thermodilution for monitoring cardiac output responses to changing left ventricular function.
To determine the responsiveness of the pulsed Doppler technique to pacing and drug induced changes in left ventricular function 125 simultaneous cardiac output measurements by pulsed Doppler ultrasound and thermodilution were compared in 12 patients. The Doppler velocity frequencies were analysed using a signal averaging process and the validity of this method first tested in vitro. This showed almost perfect linearity of pulsed Doppler and electromagnetic flow determinations in a test rig. Although data points showed greater scatter in the clinical study, a highly significant linear relation between cardiac output measurements by pulsed Doppler and thermodilution was confirmed by regression analysis (r = 0.88, p less than 0.001). Certain mean values for cardiac output by the two techniques differed, however, by up to 0.9 litre.min-1. Despite this, changes in cardiac output in response to pacing, inotropic stimulation with dobutamine, and vasodilatation with nitrates were directionally similar, indicating a useful role for the pulsed Doppler technique in monitoring responses to treatment in the intensive care unit. Pulsed Doppler also provided a simple measure of left ventricular contractile function. Thus the inotropic response to dobutamine produced a significant rise in peak aortic flow velocity, and this variable was unaffected by either pacing or nitrate induced vasodilatation.
D002302:Cardiac Output / Q000187:drug effects; D002304:Cardiac Pacing, Artificial; D004280:Dobutamine / Q000494:pharmacology; D004452:Echocardiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D009566:Nitrates / Q000494:pharmacology; D012044:Regression Analysis; D013815:Thermodilution; D016276:Ventricular Function
D009566:Nitrates; D004280:Dobutamine