Hypothesis on the regulation of cytosol calcium concentration and the aging brain.
This commentary proposes that neurobiology of aging must look beyond the issue of age related changes in calcium concentrations within the cytosol. The more important question is what causes these changes. Studies of structure, function, and dynamics of membranes may begin to give a better clue about underlying mechanisms of these changes.
D000375:Aging / Q000378:metabolism*; D000544:Alzheimer Disease / Q000209:etiology; D001921:Brain / Q000378:metabolism*; D002128:Calcium Metabolism Disorders / Q000209:etiology*; D003600:Cytosol / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D009474:Neurons / Q000378:metabolism