Hemodynamic characteristics of echocardiographic findings in hypertensive patients with negative U waves and effect of an antihypertensive drug, tripamide.
Twenty-four hypertensive patients were divided into a group A with negative U waves (n = 8, mean age, 50 +/- 11 years) and a group B without negative U waves (n = 16, mean age, 49 +/- 11 years). Echocardiographic findings were compared with a group of 20 age-matched normotensive subjects without cardiovascular disease (mean age, 49 +/- 11 years). In addition, the effects of the antihypertensive agent tripamide were assessed in groups A and B. Although hemodynamic parameters such as left ventricular end-systolic and diastolic dimensions, stroke volume and cardiac output were elevated in group A, group B showed an increase in total peripheral resistance. Thus, group A was characterized by high cardiac output, while group B displayed increased peripheral resistance. Tripamide was administered to 14 patients. In group A (6 patients receiving tripamide), left ventricular end-systolic and end-diastolic dimensions were significantly reduced by tripamide along with stroke volume and cardiac output. However, in group B the only significant change in hemodynamic parameters after tripamide administration was a drop in total peripheral resistance. These findings suggest that both the hemodynamics of hypertensive patients and responses to tripamide vary with the presence of negative U waves.
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004232:Diuretics / Q000627:therapeutic use*; D004341:Drug Evaluation; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013449:Sulfonamides; D013997:Time Factors
D000959:Antihypertensive Agents; D004232:Diuretics; D007211:Indoles; D013449:Sulfonamides; C031282:tripamide