title: Effects of ingested gossypol on the ultrastructure of rat ovarian follicles.
abstract: Ultrastructural changes were observed in the oocytes and granulosa cells of the ovarian follicles of sexually mature female rats treated daily for 60 days with gossypol acetic acid at a dosage known to induce sterility in male rats (20 mg/kg body weight, orally). The changes included an increased lysosomal population in the ooplasm and a reduced, poorly developed smooth endoplasmic reticulum in the granulosa cells. The latter changes suggest a suppression of the secretory activity of the granulosa cells.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005260:Female; D006072:Gossypol / Q000008:administration & dosage / Q000494:pharmacology*; D006107:Granulosa Cells / Q000187:drug effects / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009865:Oocytes / Q000187:drug effects / Q000648:ultrastructure; D006080:Ovarian Follicle / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure*; D051381:Rats; D012741:Sexual Maturation
chemical_list: D006072:Gossypol