Chloramphenicol-resistant Salmonella typhi in Durban, South Africa.
A retrospective survey was undertaken to determine the incidence of chloramphenicol-resistant Salmonella typhi in Durban, South Africa. Of the 3313 strains tested over a 7 year period 20 (0.6%) showed intermediate resistance to chloramphenicol and 19 (0.6%) were fully resistant. Resistance to chloramphenicol was found to fluctuate over the period studied (0-2%). Resistance to ampicillin/amoxycillin was encountered less frequently (0-0.9%). For the present we would still recommend chloramphenicol or amoxycillin for the initial treatment of typhoid fever in this region.
D000667:Ampicillin / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology*; D006801:Humans; D010403:Penicillin Resistance; D012189:Retrospective Studies; D012485:Salmonella typhi / Q000187:drug effects* / Q000302:isolation & purification; D013019:South Africa
D002701:Chloramphenicol; D000667:Ampicillin