Immunological and haematological changes during high-dose immunoglobulin therapy in an infant with autoimmune neutropenia.
High-dose immunoglobulin (HD-Ig) therapy was given to an infant with autoimmune neutropenia (AIN), and antineutrophil autoantibodies (ANAA). The patient's absolute neutrophil count in peripheral blood increased from 300/mm3 to 3000-4000/mm3 7 days after treatment. Although the neutrophil count gradually decreased thereafter, transient increases were observed after each single booster infusion repeated at 3-week intervals. By continuing this treatment, clinical symptoms were markedly alleviated, and the patient's susceptibility to infection was reduced. The increase in neutrophils showed a positive correlation with the increase in serum IgG, and with the increase in the ratio of the T helper/T suppressor cells. The neutrophil-bound IgG level and serum lysozyme level were decreased after HD-Ig therapy.
D000380:Agranulocytosis / Q000628:therapy*; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D009503:Neutropenia / Q000276:immunology / Q000628:therapy*; D009504:Neutrophils / Q000276:immunology*
D001323:Autoantibodies; D007074:Immunoglobulin G