Evidence for a role of the plasma kallikrein-kinin system in acute inflammation: reduced exudation during carrageenin- and kaolin-pleurisies in kininogen-deficient rats.
Experimental pleurisy was induced by intrapleural injection of carrageenin or kaolin in three strains of rat: Brown Norway-Katholiek (B/N-Ka), Brown Norway-Kitasato (B/N-Ki) and Sprague-Dawley (SD). B/N-Ka rats (kininogen-deficient) showed significantly less pleural fluid accumulation and exudation rate than SD rats or than B/N-Ki rats (normal). The result indicates the involvement of the plasma kallikrein-kinin system in these pleurisies and a role of high-molecular-weight kininogen is suggested.
D000208:Acute Disease; D000375:Aging; D000818:Animals; D001835:Body Weight; D002351:Carrageenan; D007249:Inflammation / Q000201:enzymology / Q000503:physiopathology*; D007610:Kallikreins / Q000378:metabolism*; D007616:Kaolin; D007704:Kininogens / Q000378:metabolism*; D007705:Kinins / Q000378:metabolism*; D009929:Organ Size; D010998:Pleurisy / Q000201:enzymology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013755:Tetradecanoylphorbol Acetate
D007704:Kininogens; D007705:Kinins; D007616:Kaolin; D002351:Carrageenan; D007610:Kallikreins; D013755:Tetradecanoylphorbol Acetate