Molecular mechanisms underlying age-dependent alterations in calcium homeostasis: the need for more information and new tools.
The picture that emerges from the numerous studies on altered calcium regulation in the nervous system as a function of aging does not permit the formulation of a scheme that accounts for available data. The solution to this dilemma requires a more complete understanding of the calcium regulating systems and new tools with which to probe the molecular events responsible for physiological and behavioral alterations in the aging organism.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*
D002118:Calcium