title: Erythrocyte sodium transport in normotensive and hypertensive patients on chronic hemodialysis, acute effect of treatment.
abstract: Patients on chronic hemodialysis were divided into two groups: normotensive patients (group I) and renal hypertensive patients treated with antihypertensives (group II). The sodium and potassium contents in red blood cells ([Na+]i, [K+]i), ouabain-resistant net sodium uptake (ORNa+ uptake, phi Na), the relative ORNa+ uptake (k), the mean cell hemoglobin concentration (MCHC), and acid-base status were examined just before and after dialysis. The results indicate that in treated renal hypertensive patients k is stimulated and causes lower red blood cell sodium content. The reason for this increase remains obscure: the pattern of alterations of the sodium transport components during dialysis is similar in all patients: [Na+]i and phi Na increase significantly during dialysis, and the increases in [Na+]i are closely related to increases in pH and bicarbonate.
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001692:Biological Transport; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood* / Q000628:therapy; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008297:Male; D011188:Potassium / Q000097:blood; D006435:Renal Dialysis; D012964:Sodium / Q000097:blood*
chemical_list: D000959:Antihypertensive Agents; D012964:Sodium; D011188:Potassium