[Absorption of 5-FU orally administered in a patient with postoperative gastric cancer under artificial dialysis].
A patient under artificial dialysis due to chronic renal failure suffered from gastric cancer concurrently. This patient underwent subtotal gastrectomy followed by consecutive oral administration of 5-FU (tablets) as a postoperative adjuvant chemotherapy. The 5-FU level in the peripheral blood on oral administration at 50 mg remained at 0.007-0.01 microgram/ml over 2 hours. This feature of 5-FU blood level is not seen in gastric cancer patients with normal renal functions on administration of 5-FU tablets, and it seems to approximate the features of a 5-FU prodrug level in the blood upon oral administration. Neither the influence of dialysis on the absorption of orally administered 5-FU nor side effects caused by 5-FU were observed. The above findings suggest that it may be possible to maintain a certain blood level of 5-FU and to perform adjuvant chemotherapy even in cancer patients under artificial dialysis, as long as the dose is controlled carefully.
D000284:Administration, Oral; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage* / Q000097:blood; D005743:Gastrectomy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D006435:Renal Dialysis; D013274:Stomach Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000601:surgery
D005472:Fluorouracil