Computer-assisted predictive mathematical relationship among metrazol dose and time and mortality in mice.
A microcomputer program in BASIC for predicting mortality in mice administered metrazol is designed. A formula published by the author to express the mathematical relationship among the drug dose, the time after administration, and the biological response was used in this program. Analysis of the actual and the computer-assisted predicted mortalities has shown that the program is fairly accurate and reliable in expressing tolerance of mice as a function of the dose and the time.
D000818:Animals; D001699:Biometry; D003201:Computers; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D007928:Lethal Dose 50; D051379:Mice; D010433:Pentylenetetrazole / Q000008:administration & dosage / Q000633:toxicity*; D012984:Software; D013997:Time Factors
D010433:Pentylenetetrazole