title: Opossum adrenal medulla: II. Differentiation of the chromaffin cell.
abstract: The ultrastructure of the opossum adrenal medulla was examined in its postnatal development. Maturation of chromaffin cells and genesis of chromaffin vesicles were of particular interest. The primitive sympathetic cell was seen to contain few organelles with no apparent polarity. Initial pheochromoblasts contained more organelles with some polarity. Endoplasmic reticulum and the Golgi complex increased as the pheochromoblasts matured, which suggested increased synthetic activity. Structures resembling Golgi/endoplasmic reticulum/lysosome (GERL) systems were seen in the pheochromoblasts. It is suggested that some of the components of the chromaffin vesicle may be processed by the GERL while others come directly through the Golgi complex. It is stressed that the developing pheochromoblast in the opossum presents an interesting model in which to study the genesis of the chromaffin vesicle.
mesh_terms: D000313:Adrenal Medulla / Q000166:cytology*; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002395:Catecholamines / Q000378:metabolism; D002454:Cell Differentiation; D002837:Chromaffin Granules / Q000378:metabolism / Q000648:ultrastructure; D002838:Chromaffin System / Q000166:cytology*; D008854:Microscopy, Electron; D009893:Opossums / Q000033:anatomy & histology*
chemical_list: D002395:Catecholamines