title: Cervical dilation before first-trimester elective abortion: a controlled comparison of meteneprost, laminaria, and hypan.
abstract: Preoperative cervical dilation makes first-trimester abortion safer, but increases costs and inconvenience to patients if extra visits are required. Eighty-four pregnant primigravid volunteers who requested first-trimester abortion were assigned randomly to one of four study groups: placebo, 16 dimethyl prostaglandin E2 (PGE2) vaginal suppository, 4-mm hypan plastic dilator, or small Laminaria japonica tent. This grouping was done to determine which of three modalities is most effective for cervical dilation within three hours before abortion. After three to four hours of treatment, hypan achieved greater cervical dilation among primigravid women and only modestly increased side effects, as compared with 16 dimethyl PGE2 suppositories or laminaria tents.
mesh_terms: D015064:16,16-Dimethylprostaglandin E2 / Q000031:analogs & derivatives; D000028:Abortion, Induced; D000180:Acrylic Resins; D000282:Administration, Intravaginal; D000328:Adult; D002584:Cervix Uteri / Q000502:physiology; D005260:Female; D006801:Humans; D007795:Laminaria; D011459:Prostaglandins E, Synthetic; D012624:Seaweed; D013488:Suppositories
chemical_list: D000180:Acrylic Resins; D011459:Prostaglandins E, Synthetic; D013488:Suppositories; C025505:meteneprost; C036441:Hypan; D015064:16,16-Dimethylprostaglandin E2