Accumulation of ceroid in smooth muscle indicates severe malabsorption and vitamin E deficiency.
Four patients had accumulation of ceroid in smooth muscle (lipofuscinosis), which indicated severe or uncontrolled malabsorption, with confirmed vitamin E deficiency in three cases. The distribution of the pigment was systematic, and there seemed to be an association between malabsorption syndrome and vitamin E deficiency. Vitamin E supplementation seems to be indicated in such patients, and it is suggested that studies of smooth muscle function should be made in cases of heavy accumulation of ceroid.
D000328:Adult; D000368:Aged; D002566:Ceroid / Q000378:metabolism*; D004947:Esophagus / Q000473:pathology; D006801:Humans; D007583:Jejunum / Q000473:pathology; D008286:Malabsorption Syndromes / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000378:metabolism* / Q000473:pathology; D010860:Pigments, Biological / Q000378:metabolism*; D014811:Vitamin E Deficiency / Q000175:diagnosis / Q000473:pathology*
D002566:Ceroid; D010860:Pigments, Biological