title: Inhalation deposition and retention patterns of a U-Pu chain aggregate aerosol.
abstract: Chain aggregate aerosol particles are normally formed during many high-temperature combustion and vaporization processes. The shape of chain aggregate aerosol particles could have an effect on the pattern of inhalation deposition and retention of the particles in the respiratory tract. A chain aggregate aerosol of nuclear reactor fuel could be present as an inhalation hazard if it were released to the atmosphere after a meltdown, core-disruptive accident. Rats were exposed to a chain aggregate U-Pu aerosol made by laser vaporization of mixed-oxide, breeder reactor fuel (20% plutonium dioxide and 80% uranium dioxide), then sacrificed to measure the clearance and retention of the fuel aerosol particles. Deposition of the 0.7-micron (activity median aerodynamic equivalent diameter) aerosol particles resulted in an average initial lung burden of 4140 Bq alpha activity. The chain aggregate particle shape was not a major factor in the total deposition; however, it may have influenced the regional distribution of the activity deposited. Retention of the particles in the upper airways of the tracheobronchial tree was on the order of 1% of the concurrent lung burden, which is consistent with recent data of other investigations. This study indicates that insoluble chain aggregate particles are retained in the tracheobronchial airways to a degree similar to simple spherically shaped particles of equivalent volume diameter.
mesh_terms: D000336:Aerosols; D000818:Animals; D001822:Body Burden; D004064:Digestive System / Q000378:metabolism; D005260:Female; D008168:Lung / Q000378:metabolism; D009688:Nuclear Reactors; D011005:Plutonium / Q000378:metabolism* / Q000493:pharmacokinetics; D051381:Rats; D012137:Respiratory System / Q000378:metabolism*; D014501:Uranium / Q000378:metabolism* / Q000493:pharmacokinetics
chemical_list: D000336:Aerosols; D014501:Uranium; D011005:Plutonium