In vitro and in vivo study of fosfomycin in methicillin-resistant Staphylococcus aureus septicaemia.
Five hundred strains of methicillin-resistant Staphylococcus aureus were tested against various anti-staphylococcal agents. Vancomycin, fusidic acid and fosfomycin were found to be the most effective. Only 1 strain out of 500 was resistant to fosfomycin. Three patients with methicillin-resistant Staphylococcus aureus septicaemia were successfully treated by fosfomycin. We conclude that fosfomycin could be the drug of choice for methicillin-resistant Staphylococcus aureus infection.
D000328:Adult; D005260:Female; D005578:Fosfomycin / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008712:Methicillin / Q000494:pharmacology*; D008875:Middle Aged; D010403:Penicillin Resistance; D018805:Sepsis / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects
D005578:Fosfomycin; D008712:Methicillin