Reexamination of the relationship between alcohol preference and brain monoamines in inbred strains of mice including senescence-accelerated mice.
The relationship between voluntary alcohol consumption and brain monoamine levels was studied in the inbred strains of C57BL/6N, C57BL/6J, A/J, BALB/cA, CBA/N, C3H/He and DBA/2cr mice; the congeneric mouse strain, B10.Br/Sg, and the senescence accelerated mouse (SAM P1, SAM P2). The C57BL strains exhibited a high alcohol preference whereas the other strains exhibited a low alcohol preference. A clear positive relationship was found between alcohol intake (g/kg/day) and brain norepinephrine level (r = 0.683, p less than 0.05), and a clear negative relationship between alcohol intake and brain serotonin level (r = -0.628, p less than 0.05). The content of brain dopamine was not clearly correlated with alcohol intake (r = -0.206, p greater than 0.05). These findings suggest that in mice voluntary alcohol preference is influenced by brain norepinephrine and serotonin levels genetically.
D000428:Alcohol Drinking; D000818:Animals; D001923:Brain Chemistry; D004298:Dopamine / Q000032:analysis*; D005518:Food Preferences; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D009638:Norepinephrine / Q000032:analysis*; D012701:Serotonin / Q000032:analysis*
D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine