[Comparison of changes in succinate dehydrogenase activity in blood lymphocytes and modification of radiosensitivity by exogenous hypoxia].
Radioprotective efficiency of gas hypoxic mixtures (GHM) containing 5-12% of oxygen and the rate of the reaction of succinate dehydrogenase (VSDG) activity in peripheral blood lymphocytes upon breathing GHM were comparatively studied in rats and dogs. VSDG was 4393.5 (%O2)-2.58 and 130.76 (%O2)-1.42 in dogs and rats respectively. Taking into account that DMF in rats is a function of oxygen concentration in the mixture one can obtain a formula for determining a dose modifying factor (DMF) as a function of the rate of SDG activity reaction.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008214:Lymphocytes / Q000201:enzymology*; D010100:Oxygen / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000201:enzymology / Q000517:prevention & control; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents; D051381:Rats; D013385:Succinate Dehydrogenase / Q000097:blood*
D011837:Radiation-Protective Agents; D013385:Succinate Dehydrogenase; D010100:Oxygen
Sopostavlenie izmeneniia aktivnosti suktsinatdegidrogenazy v limfotsitakh krovi i modifitsiruemoĭ radiochuvstvitel'nosti pod vliianiem ékzogennoĭ gipoksii.