title: Guaifenesin alone or in combination with ketamine or sodium pentobarbital as an anesthetic in rabbits.
abstract: Guaifenesin was administered alone and in combination with ketamine or sodium pentobarbital to adult New Zealand white rabbits. A solution of 5% guaifenesin in 5% dextrose given intravenously at a dosage of 200 mg/kg, abolished the pedal, palpebral and corneal reflexes for up to 15 minutes with little influence on cardiopulmonary function. Guaifenesin (200 mg/kg, intravenously) and ketamine (50 mg/kg, intramuscularly) produced effective and safe surgical anesthesia for over 30 minutes. This combination mildly depressed respiratory rate but heart rate and arterial blood pressure were not significantly affected. Guaifenesin (200 mg/kg, intravenously) was combined with sodium pentobarbital (20 mg/kg, intravenously) to produce surgical anesthesia for a period of more than 30 minutes. This combination depressed respiratory rate, produced a tachycardia and decreased arterial blood pressure.
mesh_terms: D000771:Anesthesia, Intravenous / Q000662:veterinary*; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects*; D004338:Drug Combinations; D005260:Female; D006140:Guaifenesin / Q000494:pharmacology*; D007649:Ketamine / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology*; D011817:Rabbits; D012119:Respiration / Q000187:drug effects*
chemical_list: D004338:Drug Combinations; D006140:Guaifenesin; D007649:Ketamine; D010424:Pentobarbital