Domination of a strong antagonist over a weak one in paradoxical responses to cholinolytics in a parasympathetically denervated human salivary parotid gland: atropine and metacine as agonists, and chlorosyle as partial agonist.
1. Chlorosyle, a modified asymmetric and somewhat heavier cholinolytic, produces a lower, by its level, paradoxical salivary effect in the human denervated parotid gland than atropine and metacine. 2. When chlorosyle acts in combination with atropine and metacine, the former inhibits the effect of the latter two and only the chlorosyle effect dominates. 3. Using atropine and metacine, which are complete agonists, chlorosyle, in this situation, plays the role of a partial agonist.
D001285:Atropine / Q000494:pharmacology; D001561:Benzilates / Q000494:pharmacology; D002794:Choline / Q000031:analogs & derivatives / Q000494:pharmacology; D003714:Denervation; D006801:Humans; D010276:Parasympatholytics / Q000494:pharmacology*; D010306:Parotid Gland / Q000187:drug effects* / Q000294:innervation; D010862:Pilocarpine / Q000037:antagonists & inhibitors; D012472:Salivation / Q000187:drug effects*
D001561:Benzilates; D010276:Parasympatholytics; D010862:Pilocarpine; C053908:metacine; C053909:chlorozil; D001285:Atropine; D002794:Choline