[Discovery of a placental variant of human growth hormone: biochemistry, physiology and implication in the secretion of hypophyseal forms].
Using two monoclonal antibodies (Mabs), each specific of two distinct hGH epitopes, we evidenced a decrease in serum 22K hGH in pregnant women and increasing levels of a GH-related factor, different from hPL. This factor was extracted from the placenta and partially characterized. Because of its binding to GH hepatic receptors with at least the potency of 22K hGH, it was named human placental growth hormone (hPGH). This hormone alone or together with hPL could therefore take over the role of the lacking pituitary GH in the mother during the last half of pregnancy.
D005260:Female; D013006:Growth Hormone / Q000502:physiology*; D006801:Humans; D008970:Molecular Weight; D010902:Pituitary Gland / Q000378:metabolism*; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy
D013006:Growth Hormone
Découverte d'un variant placentaire de l'hormone de croissance humaine: biochimie, physiologie et implication dans la sécrétion des formes hypophysaires.