Ischemia in aged brain.
A 15-min complete cerebral ischemia, and repetitive ischemic insults of 15-min duration each cause changes in brain cortical glucose and energy metabolism which are similar in quality but different in quantity. Abnormalities in glycolytic flux, lactate production, cessation of oxidation and energy production were found to be more pronounced with advancing age, thus indicating a reduced biological plasticity of the brain to meet emergency conditions. Repeatedly occurring ischemic insults may damage energy metabolism in particular.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005947:Glucose