Comparative anti-fertility effects of gossypol enantiomers in male hamsters.
The enantiomers of gossypol have been tested as male oral anti-fertility agents in hamsters. As determined by fertility tests the (-) isomer was fully active at half the effective dose of the racemate, whereas the (+) isomer exerted no anti-fertility effect.
D000818:Animals; D006224:Cricetinae; D005298:Fertility / Q000187:drug effects*; D006072:Gossypol / Q000494:pharmacology*; D007536:Isomerism; D008297:Male; D008647:Mesocricetus
D006072:Gossypol