title: Changes in chest wall structure and elasticity in elastase-induced emphysema.
abstract: The present study examined the effects of elastase-induced emphysema on the structure and elasticity of the chest wall. Specifically, we examined the passive pressure-volume relationship of the intact chest wall in anesthetized animals and the stress-strain relationship of the isolated rib cage devoid of respiratory musculature. The structure of the isolated rib cage was assessed by measuring its circumferential, anterior-posterior, and transverse dimensions, the angles of articulation of the ribs at the costovertebral and sternochondral joints, and the length of the sternum and individual ribs. Studies were performed in 10 Syrian Golden hamsters, 26-27 wk after intratracheal injection of elastase, and 9 saline-injected hamsters that served as controls. Mean functional residual capacity of emphysematous animals was 239% of the value obtained in control animals. In emphysematous animals, the pressure-volume curve of the chest wall was shifted parallel and to the left of the curve obtained in controls. That is, at any given esophageal pressure, lung volume was significantly greater in emphysematous animals compared with controls, but the slope of the pressure-volume relationship was similar in the two groups. In the relaxed position, the circumference, anterior-posterior, transverse, and rostral-caudal dimensions of the thorax were significantly greater in emphysematous than control animals. Although the length of the thoracic spinal column was the same in both groups, the length of the ribs and sternum were greater in emphysematous animals and the angles of articulation of the ribs with the vertebrae and sternum were altered.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000818:Animals; D006224:Cricetinae; D004548:Elasticity; D004646:Emphysema / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D005652:Functional Residual Capacity; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D010196:Pancreatic Elastase; D011312:Pressure; D012272:Ribs / Q000473:pathology*; D013314:Stress, Mechanical; D013909:Thorax / Q000473:pathology* / Q000503:physiopathology
chemical_list: D010196:Pancreatic Elastase