Chromosomal and cell kinetic pattern in human transitional cell bladder carcinoma.
Cell kinetics in transitional cancer of the bladder was studied in 35 patients by using the in vitro 3H-thymidine labeling index. The proliferative activity was remarkably lower than that observed for other human histotypes. Analysis of the relation between cell kinetics and histologic grading showed a value for grade III tumors two-fold that of grade I and grade II tumors. Cytogenetic analysis was possible in 15 cases, and different chromosome numbers from 40 to 120 and the presence of various structural aberrations were observed. When cytogenetic features were analyzed in relation to cell kinetics, higher proliferative activities were always associated with a loss of chromosome 13 and, except for one case, with a loss of chromosome 22.
D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000648:ultrastructure*; D002455:Cell Division; D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D007700:Kinetics; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000648:ultrastructure*