A new peptide boronic acid inhibitor of elastase-induced lung injury in hamsters.
A highly effective, reversible elastase inhibitor, MeOSuc-Ala-Ala-Pro-boroVal-OH, was tested for its ability to prevent emphysema induced by intratracheally administered elastase in hamsters. Anesthetized hamsters were given elastase intratracheally with or without the inhibitor or were given elastase intratracheally and the inhibitor intraperitoneally. Two weeks after administration, lungs were removed, and static air pressure volume curves were performed followed by intratracheal fixation and morphometric determination of mean linear intercepts. The results indicate significant preservation of structure and function whether the inhibitor is given intratracheally or intraperitoneally and suggest that this inhibitor may be useful in controlling diseases arising from aberrant proteolysis by elastolytic enzymes.
D000818:Animals; D001897:Boronic Acids / Q000097:blood / Q000627:therapeutic use*; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D008647:Mesocricetus; D009842:Oligopeptides / Q000097:blood / Q000627:therapeutic use*; D010196:Pancreatic Elastase; D010455:Peptides / Q000627:therapeutic use*; D012129:Respiratory Function Tests
D001897:Boronic Acids; D009842:Oligopeptides; D010455:Peptides; C048437:methyl-O-succinyl-alanyl-alanyl-prolyl-borovaline-pinacol; D010196:Pancreatic Elastase