title: Relationship between hepatic levels of glutathione and sulphobromophthalein retention in hyperthyroidism.
abstract: 1. Sulphobromophthalein (BSP) retention and liver glutathione levels were studied in uncomplicated hyperthyroid patients. 2. BSP retention was increased in 52.5% of the subjects at admission (n = 40) and in 28% of the cases after 3 months of propylthiouracil treatment (300-400 mg/day) (n = 25). 3. Hepatic levels of glutathione were measured in six patients and significant inversed power correlation with BSP retention was observed (r = 0.968, P less than 0.001). 4. These data support the contention that the alteration of the BSP retention observed in hyperthyroidism could be due to a decreased availability of hepatic glutathione for conjugation.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013448:Sulfobromophthalein / Q000378:metabolism*
chemical_list: D013448:Sulfobromophthalein; D005978:Glutathione