A new mouse TCR V gamma gene that shows remarkable evolutionary conservation.
We have identified a new mouse T-cell receptor V gamma gene segment, V gamma 4.4, which frequently undergoes rearrangements in AKR thymomas, and at a lower frequency in fetal thymocytes. V gamma 4.4 is the fourth and the most 5' V gene segment in the gamma 4 cluster, being 7.3 kb from V gamma 4.3. Surprisingly, V gamma 4.4 is more homologous to eight human V gamma genes than to the other mouse V gamma genes. It has only a 38% nucleotide and 21% amino acid sequence homology to the most homologous mouse V gamma gene (V gamma 4.1), whereas these homologies to the human V gamma 8 gene are as high as 68% and 48% respectively.
D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D005796:Genes; D006801:Humans; D051379:Mice; D008806:Mice, Inbred AKR; D008969:Molecular Sequence Data; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D013945:Thymoma / Q000276:immunology; D013953:Thymus Neoplasms / Q000276:immunology
D011948:Receptors, Antigen, T-Cell