Serum phenytoin during pregnancy, labor and puerperium.
111 pregnancies of epileptic women on phenytoin therapy were observed in a prospective study. Maternal serum phenytoin concentrations were measured monthly or bi-weekly during pregnancy, labor and puerperium. The concentration decreased towards the end of pregnancy and was lowest at delivery. In 48% of the patients the drug dosage had to be increased to combat the increased seizure frequency.
D000328:Adult; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000097:blood*; D009994:Osmolar Concentration; D010672:Phenytoin / Q000097:blood* / Q000627:therapeutic use; D049590:Postpartum Period / Q000097:blood*; D011247:Pregnancy / Q000097:blood*
D010672:Phenytoin