Anti-inflammatory effect of a selective inhibitor of elastase, cathepsin G and chymotrypsin on carrageenin-induced inflammation in rats.
The anti-inflammatory activity of a proteinase inhibitor on carrageenin-induced inflammation was studied by using N-(2,4-dinitrophenyl)-benzisothiazolinone-1,1-dioxide, a selective inhibitor of elastase, cathepsin G and chymotrypsin. The selective inhibitor suppressed leukocyte chemotaxis in vivo and in vitro, vascular permeability and development of granulation tissue. These results suggest that a selective inhibitor of elastase, cathepsin G and chymotrypsin is an effective agent for suppression of induction and development of carrageenin-induced inflammation in rats.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002351:Carrageenan; D056649:Cathepsin G; D002403:Cathepsins / Q000037:antagonists & inhibitors*; D002463:Cell Membrane Permeability / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D007249:Inflammation / Q000209:etiology / Q000517:prevention & control; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D012697:Serine Endopeptidases
D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D002403:Cathepsins; D012697:Serine Endopeptidases; D002918:Chymotrypsin; D056649:Cathepsin G; C534097:Ctsg protein, rat; D010196:Pancreatic Elastase