Serum protects HeLa cells from antiestrogen effects in culture.
The effect of nafoxidine and tamoxifen on HeLa cells is reported in this study. The two antiestrogens showed no effect on HeLa cells when grown in the presence of fetal calf serum, the cytotoxic effects were observed only under serum-free conditions. BSA also protected the HeLa cells from antiestrogen effects. The effect of nafoxidine and tamoxifen on different established cell lines and a primary culture of rat skin fibroblasts has been studied.
D000818:Animals; D001790:Blood Physiological Phenomena; D002417:Cattle; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003470:Culture Media; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005333:Fetus; D006367:HeLa Cells / Q000187:drug effects*; D006801:Humans; D009256:Nafoxidine / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013629:Tamoxifen / Q000494:pharmacology*
D003470:Culture Media; D004965:Estrogen Antagonists; D011759:Pyrrolidines; D013629:Tamoxifen; D012710:Serum Albumin, Bovine; D009256:Nafoxidine