Blood-cerebrospinal fluid barrier in schizophrenic patients.
A total of 15 young white male patients newly diagnosed as schizophrenic (DMS III) were examined for signs of blood-cerebrospinal fluid (CSF) barrier alteration and CNS IgG synthesis. Of the 15 patients, 8 exhibited signs of increased blood-CSF barrier permeability. There was a high correlation between the ratio for CSF/serum albumin concentration and the CSF total protein concentration. Local IgG synthesis in the CNS was not detected in any of the patients.
D000328:Adult; D001812:Blood-Brain Barrier; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000134:cerebrospinal fluid; D008297:Male; D010539:Permeability; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D012709:Serum Albumin / Q000032:analysis
D002556:Cerebrospinal Fluid Proteins; D007074:Immunoglobulin G; D012709:Serum Albumin