C3 and Bf complement types in chronic renal failure.
C3 and BF allele frequencies were studied in 55 patients with idiopathic membranous nephropathy (IMN) and unrelated normal individuals from North-East England. Eighteen of these IMN patients progressed to renal failure and C3*S allele showed a significant increase in these patients. A possible mechanism for this increase is briefly discussed.
D000483:Alleles; D003176:Complement C3 / Q000235:genetics*; D011415:Complement Factor B / Q000235:genetics*; D004739:England; D004792:Enzyme Precursors / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007676:Kidney Failure, Chronic / Q000235:genetics* / Q000276:immunology; D008297:Male; D010641:Phenotype
D003176:Complement C3; D004792:Enzyme Precursors; D011415:Complement Factor B