Premature centromere division (PCD): a dominantly inherited cytogenetic anomaly.
We describe a family with an increased frequency of cells with premature centromere division (PCD) of all chromosomes in four phenotypically normal individuals. This familial PCD phenomenon is apparently different from the well-described PCD of the X chromosome and from the centromere splitting in cells of patients with Roberts syndrome. Implications for genetic counseling are discussed.
D002503:Centromere; D002869:Chromosome Aberrations; D002875:Chromosomes; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D007621:Karyotyping; D008297:Male; D008938:Mitosis; D010375:Pedigree