Association between HLA-A9 and rapidly progressive periodontitis.
HLA-A, B, C, DR antigen frequencies and Properdin factor B (Bf) allotypes were studied in a group of 44 patients with rapidly progressive periodontitis. HLA-A9 (A24) was the only antigen with a frequency statistically significantly different from the control population. An increased frequency of HLA-A9 was previously reported in periodontal diseases. Our results in a well characterised group of patients adds to the evidence that HLA-A9 plays a role in the susceptibility to severe periodontitis.
D011415:Complement Factor B / Q000235:genetics; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens; D006801:Humans; D010518:Periodontitis / Q000235:genetics* / Q000276:immunology; D044465:White People
D006680:HLA Antigens; D015234:HLA-A Antigens; C037709:HLA-A9 antigen; D011415:Complement Factor B