Ability of cimetidine to increase intestinal pH of chicks.
Cimetidine was tested for its ability to increase the pH of intestinal contents of chicks. In Experiment 1, 18 mg cimetidine injected i.m. per kilogram body weight (BW) increased (P less than .05) proventricular pH within 1 hr, but proventricular pH began to decrease 4 hr postinjection. The pH of the contents of the duodenum was increased (P less than .05) 4 hr postinjection, whereas the pH of the contents of the jejunum was unaffected. In Experiment 2, 36 mg cimetidine injected i.m. per kilogram BW increased (P less than .05) the pH of the contents in the proventriculus and duodenum, but did not alter the pH in the jejunum and ileum. These results show that cimetidine can be used for experimental purposes to increase the pH of the proventricular and duodenal contents in chickens.
D000818:Animals; D002645:Chickens / Q000502:physiology*; D002927:Cimetidine / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007421:Intestine, Small / Q000187:drug effects* / Q000502:physiology; D011531:Proventriculus / Q000187:drug effects* / Q000502:physiology
D002927:Cimetidine