Acute administration of chloral hydrate depletes cardiac enzymes in the rat.
The arterioles of the left cardiac ventricle were analyzed histochemically to determine the effects of an acute administration of chloral hydrate on key enzymes of aerobic and anaerobic metabolism, as well as the hexosemonophosphate shunt in rats. Significant changes were noted in three of the 5 enzymes examined. Our data suggest that nontoxic levels of chloral hydrate can cause impaired coronary metabolism.
D000332:Aerobiosis / Q000187:drug effects; D000693:Anaerobiosis / Q000187:drug effects; D000818:Animals; D001160:Arterioles / Q000201:enzymology; D002697:Chloral Hydrate / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects*; D004798:Enzymes / Q000032:analysis; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D010427:Pentose Phosphate Pathway / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D004798:Enzymes; D002697:Chloral Hydrate