[C-alkylpiperazines. XII. Synthesis and diuretic activity of compounds structurally related to clopamide].
The synthesis and diuretic activity were reported of a series of N1-(4-chloro-3-sulfamoylbenzamide)-N4-alkylpiperazines, 2-methyl- and cis-2,6-dimethyl substituted, structurally related to clopamide, as well as of two N4-alkyl-N1-(4-chloro-3-sulfamoylbenzoyl)-2-methyl-1,2,3, 4-tetrahydroquinoxalines. In the piperazine series the presence of methyl group in position 2 and 6 of the piperazinic ring was found to increase the diuretic potency of the C-unmethylated compound.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003005:Clopamide / Q000031:analogs & derivatives*; D004232:Diuretics / Q000138:chemical synthesis*; D008297:Male; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D004232:Diuretics; D010879:Piperazines; D003005:Clopamide
C-alchilpiperazine. Nota XII--Sintesi ed attività di composti strutturalmente correlabili alla clopamide.