title: MR image-guided P-31 MR spectroscopy in the evaluation of brain tumor treatment.
abstract: Magnetic resonance (MR) image-guided phosphorus-31 MR spectra have been obtained from in situ brain tumors. The volumes of interest used for spectroscopy were defined from hydrogen-1 MR images. Direct comparisons were possible between normal and abnormal tissue, since P-31 spectra from different parts of the brain could be measured in a single examination. P-31 MR spectra of the tumors often showed abnormally high concentrations of phosphomonoesters and low concentrations of phosphocreatines. The effects of pharmacotherapy and radiation therapy were studied in three patients; in each of these cases changes were observed in the P-31 spectra of the tumor. The correlation between MR imaging and P-31 MR spectroscopy was essential for the interpretations of these results.
mesh_terms: D001921:Brain / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D010758:Phosphorus / Q000378:metabolism; D010761:Phosphorus Radioisotopes; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods*
chemical_list: D010761:Phosphorus Radioisotopes; D010758:Phosphorus