Swedish high-risk study: sample characteristics at age 6.
High-risk offspring of women with a history of nonorganic psychosis and control offspring of women with no history of psychosis were studied from the mother's pregnancy through 2 years of age and followed up at 6 years of age. The mothers tended to be older and have somewhat higher parity than did Swedish mothers in general. Sample attrition during the 6-year longitudinal period was significantly higher in the high-risk than the control sample, and selective in both groups. A limited set of early-life variables, investigated prospectively, was selected for studying the antecedents of mental disturbance in the offspring at 6 years. In the high-risk group, disturbance in the offspring was related to maternal anxiety during pregnancy, negative maternal attitude toward pregnancy, and maternal psychotic condition during the period from 6 months to 2 years post-partum, and tended to be related to low social class, male child, active maternal-mental disturbance during pregnancy, prolonged labor and low Apgar score at delivery, neonatal neurological abnormality, and anxious attachment to the mother at 1 year of age. None of these relationships (except low social class) appeared in the control group, and no significant antecedents of mental disturbance in control offspring were found among the limited set of variables studied in these analyses.
D001714:Bipolar Disorder / Q000235:genetics; D002648:Child; D003866:Depressive Disorder / Q000235:genetics; D005106:Exploratory Behavior; D005500:Follow-Up Studies; D006801:Humans; D009034:Mother-Child Relations; D009769:Object Attachment; D012306:Risk; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D012931:Social Environment; D013548:Sweden