Desensitization of dopamine receptors observed in Aplysia ganglion cells.
The time course of the current response produced by a prolonged application of dopamine (DA) was studied in Aplysia ganglion cells with different types of DA receptors. The Na+-dependent fast excitatory receptors were found to be more readily desensitized than K+-dependent inhibitory ones, whereas Na+-dependent slow excitatory ones showed little sign of desensitization.
D000818:Animals; D001048:Aplysia; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000494:pharmacology*; D005724:Ganglia / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008564:Membrane Potentials; D008839:Microelectrodes; D011188:Potassium / Q000378:metabolism; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D011954:Receptors, Dopamine; D012964:Sodium; D011188:Potassium; D004298:Dopamine