Protection of lambs with a purified metabolite of exsheathed third-stage Haemonchus contortus larvae.
Helminth-free lambs (approx 4 months old) were inoculated SC with a purified metabolite of exsheathed third-stage Haemonchus contortus larvae. The metabolite was obtained from in vitro cultivation and was identified as XL3FA1. After 3 periodic XL3FA1 inoculations, lambs were challenge exposed with H contortus. Multiple vaccinations with XL3FA1 did not inhibit the development of worm populations in the lambs; however, worm egg production seemed to be inhibited.
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D005260:Female; D006188:Haemonchiasis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D006189:Haemonchus / Q000276:immunology / Q000378:metabolism*; D007814:Larva / Q000378:metabolism; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000469:parasitology* / Q000517:prevention & control; D014251:Trichostrongyloidea / Q000378:metabolism*; D014252:Trichostrongyloidiasis / Q000662:veterinary*
D000947:Antigens, Helminth