[Characteristics of the action of extracts of pink-stained grain of fusarial and nonfusarial origin on the structure of the organs in growing rat pups].
The characteristics of the toxic effect of rose-stained grain of fusarial and non-fusarial nature, as well as the grain experimentally challenged with the toxic strain Fusarium sporotrichiella 53315, were studied basing on the analysis of morphological changes in the internal organs of young rat given orally extracts from the samples studied. The tissue aging processes under the effect of the extract doses producing no irreversible pathologic changes were investigated. It was shown that the extracts of rose-stained natural grain, fusarial and without signs of fusaridiosis, produced similar pathological changes in the morphological structures of the organs in the young rats, the toxicity grew with the increase of the per cent of rose-stained grain. Dystrophic changes in the parenchymatous organs and impairment of the structure of the immunogenesis organs were recorded with a low content of rose-stained grain (3-3.5%), the changes in some organs at the structural and cellular level were also revealed, however, they were less manifest and evidenced a regional antigenic stimulation.
D000375:Aging / Q000187:drug effects / Q000473:pathology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D002523:Edible Grain / Q000633:toxicity*; D005506:Food Contamination; D005670:Fusarium; D006128:Growth / Q000187:drug effects*; D008297:Male; D009183:Mycotoxins / Q000633:toxicity; D010935:Plant Diseases; D010936:Plant Extracts / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D009183:Mycotoxins; D010936:Plant Extracts
Osobennosti deĭstviia ékstraktov iz rozovookrashennogo zerna fuzarioznoĭ i nefuzarioznoĭ prirody na strukturu organov rastushchikh krysiat.