Influence of 5-hydroxytryptamine on the combination effect of lonidamine or gossypol and hyperthermia on Ehrlich tumour in vivo.
An experiment was conducted using lonidamine and gossypol against Ehrlich tumour in the foot pad of CD-1 mice. These compounds alone were mild antitumour agents, but their cytotoxicity increased when they were combined with hyperthermia. The antitumor effect was further increased by 5-hydroxytryptamine, particularly when combined with lonidamine.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000628:therapy*; D003131:Combined Modality Therapy; D006072:Gossypol / Q000008:administration & dosage*; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D007191:Indazoles / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000008:administration & dosage*; D012701:Serotonin / Q000494:pharmacology*
D007191:Indazoles; D011720:Pyrazoles; D012701:Serotonin; D006072:Gossypol; C016371:lonidamine