The role of group structure in the action of some morpholinium chloride derivatives on model systems.
Effects of morpholinium chlorides, which exhibit fungicidal activity, on model lipid systems is discussed. It was shown by means of DSC and BLM techniques that for different salts possessing alkyl chains of identical length, the interaction with lipids depends strongly on the polar head charge and the structure of the salt. The results obtained and conclusions drawn can be useful in explaining the possible mechanism of the biological effectiveness of the compounds tested; this is suggested by the observation that salts tested showed the same sequence of activity in both biological tests and model experiments.
D000935:Antifungal Agents / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning; D008055:Lipids; D008567:Membranes, Artificial; D009025:Morpholines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D008055:Lipids; D008567:Membranes, Artificial; D009025:Morpholines