title: Fructose 2,6-bisphosphate and glucose 1,6-bisphosphate in rabbit erythroid cells during differentiation.
abstract: Fructose 2,6-bisphosphate concentration and 6-phosphofructo-2-kinase activity markedly decrease during differentiation of rabbit erythroid cells, being higher in erythroblasts (654 +/- 97 pmol/10(9) cells; 238 +/- 81 U mu/10(9) cells) than in reticulocytes (40 +/- 15 pmol/10(9) cells; 11 +/- 3 U mu/10(9) cells) and much higher than in mature erythrocytes (10 +/- 0.8 pmol/10(9) cells; 2 +/- 1 U mu/10(9) cells). The enzymatic activities involved in glucose 1,6-bisphosphate metabolism also decrease, but the levels of aldohexose 1,6-bisphosphates remain essentially constant during differentiation of erythroid cells.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004900:Erythroblasts / Q000166:cytology* / Q000201:enzymology; D004912:Erythrocytes / Q000166:cytology* / Q000201:enzymology; D005635:Fructosediphosphates / Q000097:blood*; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives*; D005958:Glucosephosphates / Q000097:blood*; D006019:Glycolysis; D006598:Hexosediphosphates / Q000097:blood*; D011817:Rabbits; D012156:Reticulocytes / Q000166:cytology* / Q000201:enzymology
chemical_list: D005635:Fructosediphosphates; D005958:Glucosephosphates; D006598:Hexosediphosphates; D019298:Glucose-6-Phosphate; C027652:fructose 2,6-diphosphate; C016473:glucose-1,6-bisphosphate