Effects of methamphetamine administration on brain neurotensin-like immunoreactivity in rats.
The effects of methamphetamine (MAP) administration on neurotensin-like immunoreactivity (NTLI) were investigated in the rat brain. A single administration of MAP induced dose-dependent and reversible increases in NTLI in the caudate-putamen, limbic forebrain and midbrain. NTLI in the caudate-putamen, limbic forebrain and midbrain was also enhanced after repeated administration of MAP. It was assumed that MAP enhanced NTLI in the caudate-putamem, limbic forebrain and midbrain through its action upon the nigrostriatal and mesolimbic dopamine systems.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003342:Corpus Striatum / Q000032:analysis; D008032:Limbic System / Q000032:analysis; D008297:Male; D008636:Mesencephalon / Q000032:analysis; D008694:Methamphetamine / Q000494:pharmacology*; D009496:Neurotensin / Q000032:analysis*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
D009496:Neurotensin; D008694:Methamphetamine