Calcitonin induces ornithine decarboxylase in various rat tissues.
A single dose of synthetic salmon calcitonin administered to rats (20 MRC U/kg body weight) stimulated the activity of ornithine decarboxylase in the brain, liver, kidney, testis and ovaries by 3-, 15-, 5-, 2- and 2-fold respectively after 4 h of the treatment. The increase in the enzyme activity in the brain, testis and ovaries was accompanied by a comparable increase in the enzyme protein content. Hepatic and renal ornithine decarboxylase concentration increased only by 2-fold. These results suggest that calcitonin influences polyamine biosynthesis through a tissue-specific regulation of the activity and/or the number of ornithine decarboxylase molecules.
D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D007700:Kinetics; D008297:Male; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D002116:Calcitonin; D009955:Ornithine Decarboxylase; D002118:Calcium