A case of acute interstitial nephritis induced by flurbiprofen.
Recently, acute interstitial nephritis (AIN) presenting nephrotic syndrome and renal failure induced by nonsteroidal anti-inflammatory drug (NSAID) has been recognized with increasing frequency. We described here a 43-year-old woman who developed this type of nephropathy after taking NSAID for rheumatoid arthritis. Flurbiprofen (Froben) was assumed to be a causal drug based on a clinical course and a positive result of lymphocyte transformation test. Withdrawal of flurbiprofen therapy led no sufficient improvement, and high-dose steroid therapy done 15 months after the onset resulted in only a minor improvement. So far as we know, this was the second case of AIN associated with flurbiprofen and the youngest in NSAID-induced AIN with irreversible chronic renal insufficiency.
D000208:Acute Disease; D058186:Acute Kidney Injury / Q000139:chemically induced; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D005260:Female; D005480:Flurbiprofen / Q000009:adverse effects*; D006801:Humans; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D011422:Propionates / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; D005480:Flurbiprofen