[Physical dependence liability test of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016) in rats].
An acute administration of MCI-2016 at the doses of 30, 100 and 300 mg/kg (p.o.), and 10, 20 and 30 mg/kg (i.p.) produced a slight CNS depression in rats, such as, sedation, ptosis, decrease in motor activity and systemic muscle relaxation. In a direct physical dependence test, rats were fed the MCI-2016-admixed food together with drinking water ad libitum for 24 hours daily for 51-71 days (mean MCI-2016 intake 29.9-210.7 mg/kg/day), on the gradedly increased dosage schedule with a dosage level of 0.25 and 0.5 mg/g food to 4 mg/g food. In a natural withdrawal following administration of MCI-2016, no significant withdrawal signs were observed in any group. In a naloxone-precipitation test the rats that were treated with MCI-2016-admixed food did not show any withdrawal signs. In a substitution test in either morphine or barbital dependent rats, no suppression of withdrawal signs or maintenance of dependence were observed by cross-administration of MCI-2016. In conclusion, MCI-2016 was considered to have no physical dependence potential.
D000818:Animals; D000928:Antidepressive Agents; D001463:Barbiturates / Q000009:adverse effects; D001559:Benzhydryl Compounds / Q000097:blood / Q000633:toxicity; D001835:Body Weight / Q000187:drug effects; D003061:Codeine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D008297:Male; D009021:Morphine Dependence; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders
D000928:Antidepressive Agents; D001463:Barbiturates; D001559:Benzhydryl Compounds; D003975:Diazepam; D003061:Codeine; C032232:barbituric acid; C031906:bifemelane