Chronic arthritis in two children with partial deletion of chromosome 18.
We describe 2 children with a partial deletion of chromosome 18 and chronic arthritis. A boy with r(18)(p11.3; q23) lacked serum IgA and had arthritis affecting both knees. A girl with del (18)(q21.2; q22) had arthritis in 5 joints. Her serum IgA was normal. In both children, the arthritis responded to nonsteroidal antiinflammatory drugs.
D001168:Arthritis / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002887:Chromosomes, Human, Pair 18; D002908:Chronic Disease; D004406:Dysgammaglobulinemia / Q000235:genetics; D005260:Female; D006801:Humans; D017098:IgA Deficiency; D008297:Male; D012303:Ring Chromosomes