[Activity of enzymes of ethanol metabolism as a test in evaluating the effectiveness of sensitizing alcohol deterrents].
A procedure is developed for determination of the efficiency of the antialcoholic drugs' action on the system of ethanol oxidation in vitro: alcohol dehydrogenase by the direct and reverse reactions and aldehyde dehydrogenase of subcellular fractions of the rat liver. This procedure is also used to determine the antialcoholic activity of a number of new compounds and to compare them with disulphiram (antabus, teturam), the known antialcoholic drug.
D000426:Alcohol Dehydrogenase / Q000037:antagonists & inhibitors*; D000427:Alcohol Deterrents / Q000494:pharmacology* / Q000627:therapeutic use; D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors*; D000818:Animals; D004220:Disulfides / Q000494:pharmacology / Q000627:therapeutic use; D004221:Disulfiram / Q000494:pharmacology / Q000627:therapeutic use; D004341:Drug Evaluation; D000431:Ethanol / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D051381:Rats
D000427:Alcohol Deterrents; D004220:Disulfides; D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase; D004221:Disulfiram
Aktivnost' fermentov obmena étanola kak test dlia opredeleniia éffektivnosti antialkogol'nykh preparatov sensibiliziruiushchego deĭstviia.