Effect of experimental uremia upon the estrous cycle in rats.
By daily vaginal smears, uremic rats showed significantly greater prevalence of irregular estrous cycles compared with sham-operated controls (p less than 0.02). There seems to be a correlation between the degree of renal failure and estrous cycle abnormalities. The lack of LH surge on the afternoon of proestrus, found in uremic animals, suggests a defect in the positive hypothalamic steroid feedback.
D000818:Animals; D004971:Estrus; D005260:Female; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000097:blood; D009392:Nephrectomy; D051381:Rats; D014508:Urea / Q000097:blood; D014626:Vaginal Smears
D014508:Urea; D007986:Luteinizing Hormone