Diisopropanolnitrosamine (DIPN) induced rat thyroid lesions. I. A histological classification.
DIPN induced localized lesions of the rat thyroid gland are described histologically and classified into three major types: type 1, foci of cellular alteration; type 2, proliferative nodules; and type 3, overt carcinomas. Follicular, papillary and mixed papillofollicular subtypes are recognized in the type 2 lesions, and follicular, papillary, anaplastic and mixed subtypes in the type 3 lesions. The nature of the individual lesions is discussed.
D000818:Animals; D006965:Hyperplasia; D008297:Male; D009602:Nitrosamines; D051381:Rats; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000139:chemically induced / Q000145:classification / Q000473:pathology*
D009602:Nitrosamines; C012457:diisopropanolnitrosamine