Evidence for the one-electron oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+).
Optical data have shown that the neurotoxin metabolite 1-methyl-4-phenyl-2,3-dihydropyridinium undergoes one-electron oxidation/reduction in the presence of iron chelates. The activation energy for one-electron oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium is less than that for two-electron oxidation. Horseradish peroxidase catalyzes the oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium. Reactivity of 1-methyl-4-phenylpyridinyl radical is discussed in relation to the well-known pyridinyl radicals.
D005609:Free Radicals; D006735:Horseradish Peroxidase; D006861:Hydrogen Peroxide; D007502:Iron Chelating Agents; D010084:Oxidation-Reduction; D010618:Phenanthrolines; D011726:Pyridinium Compounds; D013057:Spectrum Analysis
D005609:Free Radicals; D007502:Iron Chelating Agents; D010618:Phenanthrolines; D011726:Pyridinium Compounds; C044755:1-methyl-4-phenyl-2,3-dihydropyridinium; D006861:Hydrogen Peroxide; D006735:Horseradish Peroxidase; C025205:1,10-phenanthroline