Effect of ranitidine on the absorption of aspirin.
Six healthy male volunteers received 1 week's pretreatment with ranitidine, 150 mg twice daily, and placebo in a double-blind cross-over trial. On the 8th day, each volunteer received 1 g of aspirin in order to study the pharmacokinetics of this nonsteroidal anti-inflammatory drug. The results of this study suggest that ranitidine does not induce clinically significant alterations to the kinetics of a single dose of aspirin in healthy males.
D000328:Adult; D001241:Aspirin / Q000493:pharmacokinetics*; D001682:Biological Availability; D004311:Double-Blind Method; D006207:Half-Life; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D011899:Ranitidine / Q000494:pharmacology*
D011899:Ranitidine; D001241:Aspirin