title: In vitro inhibitory effect of onion extract on hamster buccal pouch carcinogenesis.
abstract: In vitro studies were performed that used varying concentrations of onion extract added to cell cultures of an epidermoid carcinoma cell line derived from hamster buccal pouch carcinoma (HCPC-1). The studies demonstrated tumor growth inhibition beginning after 24 hours of incubation at an onion extract concentration of 25% and above in culture media. After 4 days and 10 days of incubation, there was a noted decrease in tumor proliferation. The plating efficiency for 24 hours was observed to produce a 54-89% inhibition in plating density. The results indicated here provide in vitro evidence of the inhibitory and cytotoxic activity on an oral carcinoma cell line.
mesh_terms: D000490:Allium; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002610:Cheek; D006224:Cricetinae; D007700:Kinetics; D009062:Mouth Neoplasms / Q000473:pathology*; D010936:Plant Extracts / Q000494:pharmacology
chemical_list: D010936:Plant Extracts