Quantitative analysis of intestinal ulceration induced by indomethacin, in rats.
It has been developed a new simple method for the evaluation of intestinal ulceration induced by indomethacin or other drug in rats. It is well known that the erosion caused by ulcerogenesis leads to the weakening of the strength of the intestinal wall. Simply measuring the tensile strength of intestinal wall, by inflatation, in the experimental animals provides quantitative indices of the severity of ulceration.
D000818:Animals; D005260:Female; D007213:Indomethacin / Q000633:toxicity*; D007410:Intestinal Diseases / Q000139:chemically induced* / Q000473:pathology; D007421:Intestine, Small / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013718:Tensile Strength; D014456:Ulcer / Q000139:chemically induced* / Q000473:pathology
D007213:Indomethacin