title: Motility in auditory sensory cells.
abstract: Three different procedures were employed to induce contraction of isolated cochlear outer hair cells. When cells were permeabilized and exposed to calcium and ATP both a shortening of cell length (14%) and a decrease in cell diameter (12-16%) was observed indicating a longitudinal and a circumferential contraction. When intact cells were treated with positively charged ferritin a shortening of about 10% was observed together with an increase in cell diameter. Application of solutions containing high potassium concentrations gave similar but more rapid results as compared with positively charged ferritin. The observed responses of inner ear sensory cells together with their morphological and immunohistochemical characteristics further support the idea that the hearing organ acts as a motile system.
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects; D003056:Cochlear Nerve / Q000187:drug effects* / Q000502:physiology; D005293:Ferritins / Q000494:pharmacology; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects* / Q000502:physiology; D011188:Potassium / Q000494:pharmacology
chemical_list: D000255:Adenosine Triphosphate; D005293:Ferritins; D011188:Potassium; D002118:Calcium