title: Interaction of ethanol and acute hypoxia (7620 m) on vitamin A distribution in rat organs.
abstract: The effect of a moderate dose of ethanol (3 g/kg body weight) and acute hypoxia (282 mmHg pressure) for 6 h on vitamin A content of rat tissue has been investigated. In addition, to find the effect of ethanol administration and hypoxic exposure on freshly absorbed vitamin A, a tracer dose of 3H-retinyl acetate was administered prior to hypoxic exposure. The results indicate that ethanol and hypoxia interfere in the transfer of vitamin A stored as well as freshly absorbed, from intestine to liver. When ethanol administered rats were exposed to hypoxia, the secretion of vitamin A from liver is also disturbed. The vitamin A metabolism in the tissues like kidney and lung are affected adversely on ethanol administration and/or hypoxic exposure. This could be due to interference in the transfer of vitamin A from intestine to liver and secretion of vitamin A from liver into plasma.
mesh_terms: D000042:Absorption; D000818:Animals; D004224:Diterpenes; D000431:Ethanol / Q000494:pharmacology*; D000860:Hypoxia / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000084562:Retinyl Esters; D014018:Tissue Distribution; D014801:Vitamin A / Q000031:analogs & derivatives / Q000378:metabolism*
chemical_list: D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; D000431:Ethanol; C009166:retinol acetate