Phenotypic profile of major synovial cell populations in longstanding psoriatic arthritis.
Monoclonal antibody investigations showed that the vast majority of cells infiltrating the synovial tissue of 8 patients with longstanding psoriatic arthritis stained for both mononuclear phagocyte and class II major histocompatibility (MHC) antigens and were therefore referred to as type I synoviocytes. A minor though consistent number of cells bore solely class II MHC antigens and were recognized as type II synoviocytes, a subpopulation that has been reported to be characteristically augmented in immune synovitides. In contrast, no immunophenotypically identifiable lymphoid cells were seen. It is suggested that type I and II synoviocytes represent the late phase of the phlogistic process and contribute to maintaining the tissue injury.
D000954:Antigens, Surface / Q000032:analysis*; D001168:Arthritis / Q000235:genetics / Q000276:immunology*; D002454:Cell Differentiation; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D010641:Phenotype; D011565:Psoriasis / Q000235:genetics / Q000276:immunology*; D013583:Synovial Membrane / Q000276:immunology*
D000954:Antigens, Surface