Opioid self-administration in rats: pharmacodynamics and pharmacokinetics.
This article provides comparative data obtained during opioid self-administration in rats, using our EEG-EMG rat model of addiction. This model allows continuous recording of EEG and EMG activities and programming of intravenous drug injections. Comparative data on opioid self-administration patterns are presented. These studies on the association between EEG and behavioral correlates of opioid self-administration have contributed to the delineation of similarities and differences in pharmacodynamic and pharmacokinetic characteristics of opioids.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004195:Disease Models, Animal; D004569:Electroencephalography; D007700:Kinetics; D009294:Narcotics / Q000008:administration & dosage* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012646:Self Administration; D019966:Substance-Related Disorders / Q000209:etiology
D009294:Narcotics