title: Cytostatic activity of naturally isolated isomers of secalonic acids and their chemically rearranged dimers.
abstract: Six different secalonic acids were tested for cytostatic activity against cultured mouse leukaemia L1210 cells. Secalonic acids B and E showed rather weak activity but the other four isomers showed quite strong activity, especially secalonic acids A and D which were slightly more active than adriamycin. The chemically rearranged 2,4'-dimer of secalonic acid A showed almost the same activity as the naturally isolated 2,2'-dimer, but the activity of the 4,4'-dimer was much stronger than that of both the 2,2'-dimer and adriamycin. Interestingly, in a mouse bone marrow stem cell assay, secalonic acids F and G showed almost the same toxicity as adriamycin, but secalonic acids A and D showed rather weak toxicity. Similarly, the 2,2'-dimer of secalonic acid A showed almost the same toxicity as adriamycin, but the toxicity of the 2,4'- and 4,4'-dimers was weaker than that of the 2,2'-dimer and also that of adriamycin.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects*; D003114:Colony-Forming Units Assay; D007536:Isomerism; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000494:pharmacology*; D044004:Xanthones
chemical_list: D014966:Xanthenes; D044004:Xanthones; C009218:secalonic acid