Augmentation of haloperidol by ascorbic acid in phencyclidine intoxication.
The authors studied 40 white men with acute phencyclidine (PCP) intoxication. On a random basis, 10 were treated with ascorbic acid, 10 with placebo, 10 with haloperidol, and 10 with a combination of ascorbic acid and haloperidol. While haloperidol was significantly more effective than ascorbic acid, the combination was significantly more effective than either used alone. This combination may have a specific antipsychotic role in the emergency treatment of PCP psychosis.
D000328:Adult; D001205:Ascorbic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006220:Haloperidol / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010622:Phencyclidine / Q000506:poisoning*; D010623:Phencyclidine Abuse / Q000150:complications; D011569:Psychiatric Status Rating Scales; D011605:Psychoses, Substance-Induced / Q000188:drug therapy* / Q000523:psychology
D010622:Phencyclidine; D006220:Haloperidol; D001205:Ascorbic Acid