WEHI 164 sarcoma cells rendered resistant to monocyte-released cytotoxin are also resistant to monocyte-induced cytolysis.
WEHI 164 sarcoma cells cultured with monocyte-released cytotoxin (CF) for 4 weeks became resistant to CF-induced cytolysis and were concomitantly rendered resistant to monocyte-induced cytolysis. The resistant cell line (R-WEHI 164) has been stable with respect to resistance to monocyte- and CF-induced lysis for more than 7 months. WEHI 164 and R-WEHI 164 cells adsorbed CF and no significant difference in CF adsorption was observed. The results indicate that CF may be an effector molecule in monocyte-mediated cytolysis.
D000327:Adsorption; D000328:Adult; D000818:Animals; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D003603:Cytotoxins / Q000494:pharmacology*; D006801:Humans; D012513:Sarcoma, Experimental / Q000276:immunology*
D003603:Cytotoxins