Lack of regression of preestablished gallstones in mice.
Feeding a high cholesterol, high cholic acid diet to mice for 28 days caused increased concentrations of plasma and liver cholesterol and formation of gallstones. Removal of cholesterol and cholic acid from the diet led to normalization of plasma and liver cholesterol within 28 days. Regression of the preestablished gallstones did not occur within 107 days.
D000818:Animals; D002769:Cholelithiasis / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D002791:Cholesterol, Dietary; D019826:Cholic Acid; D002793:Cholic Acids; D004032:Diet; D005260:Female; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D002791:Cholesterol, Dietary; D002793:Cholic Acids; D002784:Cholesterol; D019826:Cholic Acid