title: Neuro-osteoarthropathy (Charcot's joint) in diabetes mellitus following revascularization surgery. Three case reports and a review of the literature.
abstract: The initial primary defect in the development of neuro-osteoarthropathy is neuropathy. Our case reports and a review of the literature strongly implicate a neurally initiated vascular reflex leading to increased blood flow. This may play a pivotal role in the development of Charcot's joint in the neuropathic limb. Mechanical trauma in an insensitive foot is contributory, but it is probably a secondary mechanism.
mesh_terms: D000328:Adult; D001177:Arthropathy, Neurogenic / Q000209:etiology*; D003929:Diabetic Neuropathies / Q000150:complications*; D005260:Female; D005528:Foot / Q000098:blood supply; D005531:Foot Deformities, Acquired / Q000209:etiology*; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology*; D012039:Regional Blood Flow; D014656:Vascular Surgical Procedures