[Effect of a phosphatidylcholine-enriched diet on the structural and functional parameters of rat liver microsomes].
The authors studied the influence of the diet enriched with phosphatidylcholine on the structural-functional parameters of microsomes: lipid peroxidation activity, the levels of cytochromes b5 and P-450, microviscosity of the lipid phase of the membrane. In experiments in vivo it was found that phosphatidylcholine per se, not combined with antioxidants, did not show antioxidant properties. Biological effects of lecithin could be explained by its role as a catalyst of the monooxygenase system in the liver, based on the correlation (r = +0.8) between the high level of cytochrome b5 and the degree of eximerization of the fluorescent probe pyrene in the microsomes.
D000818:Animals; D000975:Antioxidants; D005527:Food, Fortified; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D010084:Oxidation-Reduction / Q000187:drug effects; D010713:Phosphatidylcholines / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000008:administration & dosage
D000975:Antioxidants; D008054:Lipid Peroxides; D010713:Phosphatidylcholines; D014810:Vitamin E
Vliianie diety, obogashchennoĭ fosfatidilkholinom, na strukturno-funktsional'nye parametry mikrosom pecheni krys.