Infection-resistant continuous peritoneal dialysis catheters.
The techniques of bonding of anionic antibiotics by treatment with cationic surfactants were applied to continuous ambulatory peritoneal dialysis (CAPD) catheters. The elution of 14C-penicillin from tridodecylmethylammonium chloride (TDMAC) treated silicone elastomer catheters in dialysis solution was biphasic, with 95% dissociated from the catheter by 48 h. Forty percent of the TDMAC left the catheter surface during the initial 2 days. The ability of the surfactant TDMAC to bind antibiotics after incubation in dialysis solution correlated directly with the amount of surfactant remaining. Rats with intraperitoneal dialysis catheters were inoculated with exit site and intraluminal bacterial challenges. Intraperitoneal catheter tips treated with TDMAC-penicillin were rendered more resistant to colonization after exit site and intraluminal bacterial challenges.
D000818:Animals; D002408:Catheters, Indwelling / Q000009:adverse effects; D004353:Drug Evaluation, Preclinical; D004866:Equipment Contamination / Q000517:prevention & control*; D004867:Equipment Design; D008024:Ligands; D008297:Male; D010400:Penicillin G / Q000032:analysis / Q000627:therapeutic use; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects / Q000295:instrumentation*; D010532:Peritoneal Diseases / Q000517:prevention & control*; D000644:Quaternary Ammonium Compounds / Q000032:analysis / Q000627:therapeutic use; D011854:Radiochemistry; D051381:Rats; D011919:Rats, Inbred Strains; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013501:Surface-Active Agents / Q000032:analysis / Q000627:therapeutic use
D008024:Ligands; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; C009543:tridodecylmethylammonium; D010400:Penicillin G