Polymorphonuclear leukocyte function in psoriasis vulgaris.
Polymorphonuclear leukocyte (PMN) migration was assessed in vitro using the agarose plate method in patients with psoriasis vulgaris, and compared with an age- and sex-matched control group. No significant difference was found between the two groups in the PMN response to the chemotactic substances F-Met-Leu-Phe (FMLP) or zymosan activated serum (ZAS). Equally, the chemokinetic or chemotactic potential of psoriatic serum did not differ from control serum. Our results do not support a primary abnormality of PMN function in psoriasis.
D001168:Arthritis / Q000097:blood; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D011565:Psoriasis / Q000097:blood*