[Fibronectin level of the blood plasma of patients with congenital heart defects].
Enzyme immunoassays have shown mean fibronectin (FN) level to be 241.0 +/- 15.1 micrograms/ml in normal children between 2 and 15 years of age. Similar assays in 57 patients with congenital heart diseases (CHD) before and after surgery demonstrated preoperative FN decrease in 56% of patients, that was directly related to the extent of hemodynamic disorders, while postoperative FN level depended on the range and type of surgical trauma and the presence of inflammatory or suppurative-septic complications. Within 3 postoperative days, FN drops below normal level in 95% of patients. In spite of therapeutic use of blood and blood components, FN deficiency was not compensated for until day 10 after surgical correction of the valvular defect.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005353:Fibronectins / Q000097:blood*; D006330:Heart Defects, Congenital / Q000097:blood* / Q000601:surgery; D006801:Humans; D011183:Postoperative Complications / Q000175:diagnosis; D011184:Postoperative Period; D011379:Prognosis; D013997:Time Factors
D005353:Fibronectins
Uroven' fibronektina v plazme krovi bol'nykh vrozhdennymi porokami serdtsa.