[Effect of vicasol and protamine sulfate on the indices of the blood kallikrein-kinin system and of aortic carbohydrate metabolism in nicotine poisoning].
The experiments on rats showed that 6-day nicotine intoxication was followed by an increase of the initial esterase activity (IEA) of the blood, a decrease of oxygen uptake by the aorta tissue. Vicasol produced an activation of kininogenesis in control rats and a reduction of IEA in animals under nicotine intoxication; irrespective of the background, the drug stimulated the aorta tissue respiration. Acute administration of protamine sulfate increased IEA and against the background of nicotine intoxication it increased oxygen uptake by the vessel tissue.
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005947:Glucose / Q000378:metabolism*; D007610:Kallikreins / Q000097:blood*; D007705:Kinins / Q000097:blood*; D008297:Male; D009538:Nicotine / Q000506:poisoning*; D010101:Oxygen Consumption / Q000187:drug effects; D011479:Protamines / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors; D014812:Vitamin K / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024483:Vitamin K 3
D000931:Antidotes; D007705:Kinins; D011479:Protamines; D014812:Vitamin K; D009538:Nicotine; D024483:Vitamin K 3; D007610:Kallikreins; D005947:Glucose
Vliianie vikasola i protamina sul'fata na nekotorye pokazateli kallikrein-kininovoĭ sistemy krovi i uglevodnogo obmena aorty pri nikotinovoĭ intoksikatsii.