Glycopyrrolate compared with atropine in association with ketamine anaesthesia.
Atropine and glycopyrrolate given intravenously before the induction of a ketamine anaesthesia to diminish salivary secretion were compared for their effect on psychotomimetic side-effects, awakening time and heart rate. Though atropine is a tertiary amine that crosses the blood-brain barrier, which glycopyrrolate as a quaternary ammonium compound does not, it did not increase the incidence of psychotomimetic side-effects nor did it significantly prolong the awakening time after ketamine anaesthesia. During intubation the increase in heart rate was significantly higher following atropine than following glycopyrrolate.
D000758:Anesthesia; D001285:Atropine / Q000009:adverse effects / Q000627:therapeutic use*; D001999:Bronchoscopy; D006024:Glycopyrrolate / Q000009:adverse effects / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007649:Ketamine; D011759:Pyrrolidines / Q000627:therapeutic use*; D012463:Saliva / Q000378:metabolism; D013997:Time Factors
D011759:Pyrrolidines; D007649:Ketamine; D001285:Atropine; D006024:Glycopyrrolate