title: The liver is the main organ to clear plasma and tissue kallikreins from rat plasma, in vivo.
abstract: We report observations regarding the in vivo distribution of labelled kallikreins in plasma, liver and some other organs, twenty minutes following their intravenous injection in the rat. The kallikreins used were: tritiated homogeneous human plasma (HuPK) and horse urinary (HoUK) as well as highly purified iodinated rat plasma kallikrein (RPK). The main findings were: the liver cleared 15% of HuPK, 38% of RPK and 69% HoUK; with both types (plasma and tissue) of native kallikreins the liver was the main clearing organ.
mesh_terms: D000818:Animals; D006736:Horses; D006801:Humans; D007610:Kallikreins / Q000097:blood / Q000302:isolation & purification / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D014018:Tissue Distribution
chemical_list: D007610:Kallikreins