title: Evaluation of explanted polyurethane trileaflet cardiac valve prostheses.
abstract: Morphologic, chemical, and hemodynamic studies were made of eight prototype polyurethane trileaflet cardiac valve prostheses that had been implanted in juvenile sheep for 17 to 21 weeks in the mitral position. Calcification of the polyurethane leaflet surfaces was the principal finding. Quantitative chemical analyses revealed calcium values with a mean of 42.7 +/- 21 mg/gm dry weight of leaflet. Morphologically, two distinct types of calcification were observed: One was associated with the polyurethane surface or the interface between the leaflet surface and microthrombi or fibrous sheaths; the other was characterized by calcification associated with degenerated cells within thrombotic material and the fibrous sheath. These morphologic findings were in accord with the results of hemodynamic performance studies indicating that these heart valve prostheses had become both stenotic and regurgitant.
mesh_terms: D000818:Animals; D002114:Calcinosis / Q000209:etiology; D005069:Evaluation Studies as Topic; D005260:Female; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D008297:Male; D008943:Mitral Valve / Q000601:surgery; D011140:Polyurethanes; D011475:Prosthesis Failure; D012756:Sheep
chemical_list: D011140:Polyurethanes