Noradrenaline content and release in the mesenteric artery of stroke-prone spontaneously hypertensive rats (SHRSP) and a new strain of SHRSP (M-SHRSP).
Adrenergic innervation in the main trunk of the mesenteric artery was studied in stroke-prone spontaneously hypertensive rats (SHRSP) as well as in a new strain of SHRSP (M-SHRSP) and was compared with that of normotensive Wistar Kyoto rats (WKY). Noradrenaline (NA) content and high K-induced NA release in the artery of 6-week-old SHRSP and M-SHRSP were greater than those in the artery of WKY. These results suggest that a higher adrenergic innervation of the artery might be involved in the development of hypertension in SHRSP and M-SHRSP.
D000818:Animals; D002561:Cerebrovascular Disorders / Q000378:metabolism*; D004198:Disease Susceptibility; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism; D011919:Rats, Inbred Strains / Q000378:metabolism*; D011921:Rats, Inbred WKY / Q000378:metabolism; D011922:Rats, Mutant Strains / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
D012964:Sodium; D011188:Potassium; D009638:Norepinephrine