Posologic evaluation of clindamycin, using a canine model of posttraumatic osteomyelitis.
Posttraumatic osteomyelitis attributable to Staphylococcus aureus infection was experimentally induced in 30 dogs, after which the dogs were treated with clindamycin at various dosage regimens. Of the regimens evaluated, oral administration of 11 mg of clindamycin/kg of body weight twice daily for 28 days was the most effective treatment for the osteomyelitis.
D000818:Animals; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000188:drug therapy / Q000382:microbiology*; D004285:Dogs; D005260:Female; D007869:Leg Injuries / Q000150:complications / Q000382:microbiology / Q000662:veterinary*; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology / Q000662:veterinary*; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000662:veterinary*
D002981:Clindamycin