Clinical aspects of glomerular diseases.
This article discusses the current concepts of the pathophysiology of disturbed glomerular structure and/or function that lead to the cardinal clinical manifestations of glomerular disease, ie, alterations in glomerular filtration rate, disturbances in sodium homeostasis, proteinuria, and hematuria. The functional and anatomic bases of these alterations include changes in filtering surface area, filtration pressure and/or nephron mass, primary and secondary renal sodium and water retention, defects in size and/or charge-selective barriers to filtration of plasma proteins, and defects in capillary wall integrity. Longitudinal evaluation of albuminuria/gamma globulinuria and the investigation of dysmorphic hematuria may be helpful approaches to the study of glomerular disease.
D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000175:diagnosis*; D006417:Hematuria / Q000175:diagnosis; D006801:Humans; D007678:Kidney Glomerulus / Q000503:physiopathology; D009318:Natriuresis; D011507:Proteinuria / Q000175:diagnosis