title: Contrast-enhancing properties of Gd-DTPA at 2.0 Tesla.
abstract: The contrast enhancing properties of Gd-DTPA in various tissues, including myocardium, liver, brain, skeletal muscle, and subcutis were investigated in vivo at 2.0 Tesla. Employing T1-weighted short pulse sequences (TR = 300 msec, TE = 14 msec) signal intensity of myocardium increased by 88%, brain by 19%, liver by 61%, skeletal muscle by 50%, and subcutis by 52% at 2 min after intravenous injection of 0.2 mmol/kg Gd-DTPA in rats. Signal intensity was highest at 2 min after injection and was relatively decreased at 20 min. Tissue intensities had returned to baseline at 60 min. In a separate experiment, fast (4 sec), repeated spin-echo image acquisitions allowed for assessment of the initial, dynamic distribution pattern of Gd-DTPA between 4 sec and 72 sec after intravenous injection. Tissue signal intensities peaked between eight and 16 seconds after injection and slowly decreased thereafter. This study shows that the contrast-enhancing properties of Gd-DTPA can be effectively assessed using T1-weighted short pulse sequences at 2.0 Tesla.
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006321:Heart / Q000033:anatomy & histology; D008099:Liver / Q000033:anatomy & histology; D009682:Magnetic Resonance Spectroscopy; D009132:Muscles / Q000033:anatomy & histology; D009942:Organometallic Compounds; D004369:Pentetic Acid; D051381:Rats
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA