The effect of di- and trivalent iron on the intestinal absorption of aluminum in rats.
The effect of iron (Fe) on the intestinal absorption of aluminum (A1) was studied in an in situ perfusion system of rat small intestine in combination with systemic and portal blood sampling. The gut was perfused with media containing 0.0, 10.0, 15.0, 20.0, and 25.0 mmol/liter Al chloride and 5 mmol/liter Fe(II) or Fe(III) chloride at pH 3.0. Neither luminal disappearance nor intestinal absorption of A1 were affected by Fe(III). Fe(II), however, enhanced luminal disappearance and reduced absorption of Al.
D000535:Aluminum / Q000378:metabolism*; D000818:Animals; D005260:Female; D005290:Ferric Compounds / Q000378:metabolism / Q000494:pharmacology*; D005296:Ferrous Compounds / Q000378:metabolism / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D005290:Ferric Compounds; D005296:Ferrous Compounds; D000535:Aluminum