title: [Effect of premedication and fentanyl administration on the endocrine stress reaction during halothane anesthesia].
abstract: The influence of two different premedication regimens (diazepam versus pethidine/promethazine with fentanyl substitution before induction) on the endocrine stress-response during halothane anaesthesia was investigated in twenty orthopedic surgery patients. After premedication, the levels of plasma catecholamines, ADH, ACTH and cortisol were lower in the pethidine/promethazine-than in the diazepam-group. The levels of adrenaline remained significantly lower during the whole observation period. Thirty minutes after extubation all endocrine parameters except noradrenaline were lower in the pethidine/promethazine-group than in the diazepam-group.
mesh_terms: D000293:Adolescent; D000328:Adult; D000769:Anesthesia, Inhalation; D001285:Atropine; D003975:Diazepam; D004702:Endocrine Glands / Q000187:drug effects* / Q000503:physiopathology; D005283:Fentanyl; D006221:Halothane; D006801:Humans; D007869:Leg Injuries / Q000601:surgery; D008614:Meperidine; D008875:Middle Aged; D011229:Preanesthetic Medication / Q000379:methods*; D011398:Promethazine; D013312:Stress, Physiological / Q000097:blood / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D001285:Atropine; D008614:Meperidine; D011398:Promethazine; D003975:Diazepam; D005283:Fentanyl; D006221:Halothane
vernacular_title: Der Einfluss von Prämedikation und Fentanylgabe auf die endokrine Stress-Reaktion bei Halothan-Narkosen.