title: The efficacy of isosorbide-5-mononitrate on effort-induced electrocardiographic ischemic changes in patients with angina pectoris.
abstract: The efficacy of isosorbide-5-mononitrate 40 mg twice a day was tested in 10 patients suffering from effort-induced angina pectoris. Patients were studied with ergometer testing 6 hours after drug administration on the first treatment day, and again 8 and 12 hours after medication at 3 weeks and 6 months of therapy. At comparable and maximal workloads the patients expressed significantly less ST segment depression on treatment than prior to treatment. No tolerance was observed. Isosorbide-5-mononitrate treatment was demonstrated to have a beneficial effect on exercise tolerance in patients suffering from stable angina in effort.
mesh_terms: D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D004341:Drug Evaluation; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate