In-vitro activity of coumermycin against methicillin-resistant staphylococci: a comparison with six other agents.
The in-vitro activity of coumermycin was compared with that of vancomycin, rifampicin, fusidic acid, trimethoprim-sulphamethoxazole, norfloxacin and cefamandole against seven isolates of methicillin-resistant Staphylococcus aureus and 97 isolates of methicillin-resistant coagulase negative staphylococci. Apart from one strain of methicillin-resistant S. aureus all isolates were inhibited by less than or equal to 0.06 mg/l of coumermycin. Cefamandole was more active against strains of S. epidermidis than against other coagulase negative staphylococci.
D049933:Aminocoumarins; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003030:Coagulase / Q000032:analysis; D003374:Coumarins / Q000494:pharmacology; D008712:Methicillin / Q000494:pharmacology*; D010403:Penicillin Resistance; D013210:Staphylococcus / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects
D049933:Aminocoumarins; D000900:Anti-Bacterial Agents; D003030:Coagulase; D003374:Coumarins; C004628:coumermycin; D008712:Methicillin