Some clarifications regarding moments of residence times with pharmacokinetic models.
The stochastic formulation of linear kinetic models is elaborated in order to introduce some new concepts and help clarify the meaning and role of residence time moments. Certain conditional moments are introduced. Multicompartment and steady-state dosing within the stochastic context are considered. A general model-independent formula for steady state volume of distribution and a new concept of steady-state moments are presented. A technique for constructing a model of a given topology from its moments is also given.
D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011336:Probability
D004364:Pharmaceutical Preparations