title: Humoral and cellular immunologic aspects of adjuvant and collagen arthritis in rats.
abstract: Systemic and local immunological responses of rats sensitized with either M. butyricum or native type II collagen have been evaluated. In rats exhibiting adjuvant-induced arthritis no antibodies to collagen could be detected. In animals exhibiting collagen-induced arthritis, high antibody titers developed by day 14, and could be correlated with the severity of the arthritis. Delayed type hypersensitivity (DTH) responses were measured by a 5-iodo-2'-deoxyuridine 125-I (125-IUdR) uptake assay. Arthritic scores in rats immunized with collagen were not accompanied by a positive DTH response, whereas adjuvant arthritic rats showed a positive response. T-lymphocyte cellular responses in both adjuvant- and collagen-induced arthritic rats were measured. In neither syndrome were major alterations observed in T-lymphocyte subpopulations. These results provide evidence that adjuvant-induced arthritis and type II collagen-induced arthritis are distinct entities, and that they may be discriminated by the nature of the humoral response.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology*; D003094:Collagen; D005260:Female; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D013154:Spleen / Q000276:immunology
chemical_list: D003094:Collagen