Effects of protein intake on blood pressure, sodium metabolism, and urinary kallikrein excretion in salt-loaded rats.
Fifty-five male Wistar rats were divided into four groups and were fed (1) a control diet, (2) a high-salt low-protein (HSLP) diet, (3) a high-salt standard protein (HSSP) diet, or (4) a high-salt high-protein (HSHP) diet for 17 weeks in order to assess the effects of these diets on blood pressure, sodium metabolism, and urinary kallikrein excretion. Mean blood pressure on the 17th week was 156 +/- (SE)3 mm Hg in the HSLP group, and 152 +/- 3 mm Hg in the HSSP group. These values were significantly higher than 126 +/- 4 mm Hg in the HSHP group. Blood pressure showed reciprocal relationships to both urinary sodium and kallikrein excretion. These results suggest that high protein intake suppresses the rise of blood pressure of salt-loaded rats by facilitating sodium excretion and activating the renal kallikrein-kinin system.
D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D003404:Creatinine / Q000652:urine; D004044:Dietary Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D007610:Kallikreins / Q000652:urine*; D008297:Male; D009318:Natriuresis; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000633:toxicity
D004044:Dietary Proteins; D012965:Sodium Chloride; D003404:Creatinine; D007610:Kallikreins; D011188:Potassium