Experimental hyperthermic treatment of a human colon carcinoma xenograft. The thermal sensitivity of the tumour microcirculation.
The effect of hyperthermia on the microcirculation of a human colon tumour growing in a 'sandwich' observation chamber in immune-suppressed rats was investigated. Evaluation of the effect was based on microscopic observation, measurement of the relative flow rate of the blood in the capillaries of the tumour and photographic recording. The results indicated that moderate hyperthermia (3 h at 42.5 degrees C) has a destructive effect on the microcirculation of the tumour, followed the next day by severe necrosis. These results indicate that this human colon carcinoma xenograft has--for the endpoints that were investigated--a heat sensitivity that is comparable with rodent tumours.
D000818:Animals; D003110:Colonic Neoplasms / Q000098:blood supply / Q000628:therapy*; D004912:Erythrocytes; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008833:Microcirculation; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D013997:Time Factors