Fragile sites and chromosomal structural rearrangements in human leukemia and cancer.
Information on chromosomal structural rearrangements in leukemia and solid tumors was retracted from a computerized databank and the literature. A binomial test procedure was used to determine the statistical significance of the observed numbers of breaks. The results showed that breakage occurred preferentially in bands known to contain a fragile site and that some of them were associated with specific chromosomal structural changes in specific types of leukemia and cancer. The hypothesis of a possible relation with proto-oncogenes is also raised.
D002869:Chromosome Aberrations; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D011519:Proto-Oncogenes