Intracellular free calcium and inositol polyphosphate action as potential targets in the ageing process.
The concentration of free Ca2+ in the cell cytoplasm is likely to be the most important parameter which should be considered in assessing the contribution of Ca2+ to regulation of neurotransmitter release, memory development and cell growth. Quantitative measurement of the free Ca2+ concentration and elucidation of the membrane transduction systems which control this parameter in aged neuronal cells may make a significant contribution to further define the role of Ca2+ in the ageing nervous system.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006706:Homeostasis; D007295:Inositol Phosphates / Q000378:metabolism / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D013403:Sugar Phosphates / Q000502:physiology*
D007295:Inositol Phosphates; D013403:Sugar Phosphates; D002118:Calcium