[Effects of flunitrazepam on the baroreflex control of heart rate and on adrenergic activity].
The effects of intravenous flunitrazepam (25 micrograms . kg-1) on the baroreflex control of heart rate and plasma catecholamine levels were determined in ten ASA 1 unpremedicated patients. Plasma concentrations of flunitrazepam were also measured. The data was obtained before and 5, 10 and 15 min after flunitrazepam administration. The baroreflex gain was significantly decreased at 5 min, the time of the highest flunitrazepam plasma concentration. Catecholamine plasma levels were decreased at each study time. It was concluded that flunitrazepam induced a transient depression in baroreflex function and a sustained decrease in adrenergic activity.
D000328:Adult; D001784:Blood Gas Analysis; D004837:Epinephrine / Q000097:blood; D005260:Female; D005445:Flunitrazepam / Q000097:blood / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011311:Pressoreceptors / Q000187:drug effects*; D012018:Reflex / Q000187:drug effects*; D013564:Sympathetic Nervous System / Q000187:drug effects*
D005445:Flunitrazepam; D009638:Norepinephrine; D004837:Epinephrine
Effets du flunitrazépam sur le contrôle baroréflexe de la fréquence cardiaque et sur l'activité adrénergique.