Preliminary studies on the inflammatory stimulus induced proteins in mouse resident peritoneal macrophages.
Chemotaxis, release of lysosomal enzymes, synthesis of eicosanoids and phagocytosis are some of the important functions mediated by macrophages. Active protein synthesis have been implicated as an essential step in the mediation of these vital physiological functions. The proteins synthesized during the inflammation with microbial agents have not been identified. In the current investigation, we report the synthesis of five proteins of molecular weights 72,000; 70,000; 40,000; 34,000; and 32,000 in mouse peritoneal macrophages after incubation with inflammatory stimuli derived from microorganisms. A possible role for these proteins in phagocytosis was suggested.
D000818:Animals; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D010529:Peritoneal Cavity / Q000166:cytology; D010587:Phagocytosis / Q000187:drug effects; D014176:Protein Biosynthesis; D013211:Staphylococcus aureus; D015054:Zymosan / Q000494:pharmacology
D008070:Lipopolysaccharides; D015054:Zymosan