Anabolic and catabolic responses of human articular cells to growth factors.
The responsiveness of human synovial cells and chondrocytes to L-ascorbate, CTAP Ib, III, IV and V was assessed by assays which measured DNA and glycosaminoglycan synthesis and plasminogen activator formation. Differences in behavior were noted between synovial and cartilage derived cells and between normal and OA chondrocytes.
D001205:Ascorbic Acid / Q000494:pharmacology; D002358:Cartilage, Articular / Q000187:drug effects* / Q000378:metabolism; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D006025:Glycosaminoglycans / Q000096:biosynthesis; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D010003:Osteoarthritis / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology; D010960:Plasminogen Activators / Q000096:biosynthesis; D013583:Synovial Membrane / Q000187:drug effects* / Q000378:metabolism
D006025:Glycosaminoglycans; D006133:Growth Substances; D010455:Peptides; C009862:connective tissue-activating peptide; D004247:DNA; D010960:Plasminogen Activators; D001205:Ascorbic Acid