In vitro study of dactimicin (ST 900) against methicillin-susceptible and -resistant staphylococci.
The current knowledge on the antimicrobial activity of dactimicin is poor and limited to the study of its activity against gram-negative bacilli. The new acquisition about the use of aminoglycoside antibiotics in infections due to Staphylococci, induced us to evaluate the behavior of this drug against methicillin-susceptible and -resistant Staphylococci, in comparison with fortimicin A and amikacin. Dactimicin (ST 900) shows good antibacterial activity and a strong bactericidal effect at MIC concentrations in all strains tested.
D000583:Amikacin / Q000494:pharmacology; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008712:Methicillin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; C023527:dactimicin; C023384:fortimicin A; D000583:Amikacin; D008712:Methicillin