title: Uncharged tRNA error damping model.
abstract: Uncharged tRNA is known to bind to the ribosome in a codon-specific fashion. In this way, cognate uncharged tRNA competes with non-cognate aminoacyl-tRNA. If uncharged tRNA can be aminoacylated while on the ribosome, this will damp errors due to aminoacyl-tRNA imbalance. Kinetic analysis shows that this scheme reduces errors at 'hungry' codons considerably more effectively than J. Ninio's accuracy tuner model; for example, a 10-fold decrease in cognate aminoacyl-tRNA elicits only a 10% increase in the error frequency.
mesh_terms: D001667:Binding, Competitive; D003062:Codon; D007700:Kinetics; D008954:Models, Biological; D009154:Mutation; D010458:Peptidyl Transferases / Q000378:metabolism; D014176:Protein Biosynthesis; D012333:RNA, Messenger; D012343:RNA, Transfer / Q000378:metabolism*; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism
chemical_list: D003062:Codon; D012333:RNA, Messenger; D012346:RNA, Transfer, Amino Acyl; D012343:RNA, Transfer; D010458:Peptidyl Transferases