Hepatic intra-arterial adriamycin in metastatic leiomyosarcoma: exploiting the steep dose-response curve.
We report a case of extensive leiomyosarcoma of the liver that failed on systemic Adriamycin. Hepatic intra-arterial chemotherapy with Adriamycin has resulted in a lasting clinical remission. This report illustrates the importance of the dose-response curve of drug to tumor in regional chemotherapy as with Adriamycin used in sarcoma, and the need to further explore such therapy in moderately chemosensitive tumors that are surgically unresectable for anatomic reasons.
D000328:Adult; D004317:Doxorubicin / Q000008:administration & dosage*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D007890:Leiomyosarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D013274:Stomach Neoplasms / Q000473:pathology; D014057:Tomography, X-Ray Computed
D004317:Doxorubicin