Hypothermia induced in mice by intracerebroventricular injection of tryptamine: involvement of the 5-HT1 receptor.
The effect on the body temperature of mice of tryptamine administered by intracerebroventricular (i.c.v.) injection was studied. Tryptamine given i.c.v. produced a significant hypothermia above a dosage of 5 nmol. The hypothermic effect of tryptamine was inhibited by methysergide whereas ketanserin and p-chlorophenylalanine did not affect it. These data demonstrate that the hypothermia induced by tryptamine i.c.v. is produced by direct activation of the 5-HT1 receptor.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D014363:Tryptamines / Q000008:administration & dosage / Q000494:pharmacology*
D011985:Receptors, Serotonin; D014363:Tryptamines; C030820:tryptamine