Fatal disseminated intravascular coagulation following a monoamine oxidase inhibitor/tricyclic interaction.
In spite of intensive therapy, an otherwise fit 34-year-old man died following the hyperpyrexial reaction to an interaction between tranylcypromine and clomipramine. There was no evidence of drug overdose, but severe disseminated intravascular coagulation developed which proved fatal.
D000328:Adult; D002997:Clomipramine / Q000009:adverse effects*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced*; D004347:Drug Interactions; D005334:Fever / Q000139:chemically induced; D006801:Humans; D008297:Male; D014191:Tranylcypromine / Q000009:adverse effects*
D014191:Tranylcypromine; D002997:Clomipramine