Analysis of formulations containing pralidoxime mesylate by liquid chromatography.
An improved liquid chromatography procedure has been devised for the analysis of pralidoxime mesylate (P2S) and its degradation products in solution. An additional degradation product, 2-hydroxyaminoiminomethyl-1-methylpyridinium, has been positively identified and its route of formation and that of another recently identified product, 2-hydroxymethyl-1-methylpyridinium, has been established. Previous problems with the chromatography of 2-formyl-1-methylpyridinium have been resolved and the new method will resolve P2S and eight of its degradation products.
D000438:Alcohols; D002853:Chromatography, Liquid; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D011220:Pralidoxime Compounds / Q000032:analysis*; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet
D000438:Alcohols; D007202:Indicators and Reagents; D011220:Pralidoxime Compounds; D012997:Solvents; C028797:pralidoxime