Relationships between chemical structure and adverse effects of antibacterial and antifungal agents.
Chemical structure and adverse effects are presented, including the side chains responsible for platelet inhibitory effects, hypoprothrombinemic effects, the disulfiram effect of some betalactams as well as the structures responsible for the hemotoxic effects of chloramphenicol, the digestive intolerance and hepatotoxic effect of some macrolides, the neurotoxic effects of quinolones, the nephrotoxicity of amphotericin, aminoglycosides, and polymyxin B - colistin. The conclusions to be derived by the prescribing physician are discussed in relation with these aspects.
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000890:Anti-Infective Agents / Q000009:adverse effects*; D000935:Antifungal Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents