Stimulatory effect of mevinolin on rat liver phosphatidic acid phosphatase.
The activity of the soluble form of phosphatidic acid phosphatase in rat liver was stimulated about 2.5-fold by inclusion of mevinolin, a competitive hydroxymethylglutaryl-CoA reductase inhibitor, in the diet (0.1%). The stimulatory effect of mevinolin was present also after dietary addition of cholestyramine (5%) or intraperitoneal administration of ethanol. Addition of cholesterol (2%) to the diet totally abolished the stimulation by mevinolin on phosphatidic acid phosphatase. The results support a correlation between the synthesis of the rate-limiting enzyme in cholesterol biosynthesis and the activity of the apparent rate-limiting enzyme in triacylglycerol biosynthesis.
D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D002792:Cholestyramine Resin / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D007700:Kinetics; D008148:Lovastatin; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009281:Naphthalenes / Q000494:pharmacology*; D010712:Phosphatidic Acids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D009281:Naphthalenes; D010712:Phosphatidic Acids; D002792:Cholestyramine Resin; D000431:Ethanol; D008148:Lovastatin; D006903:Hydroxymethylglutaryl CoA Reductases; D002790:Cholesterol 7-alpha-Hydroxylase; D000135:Acid Phosphatase