title: Extracardiac pressure and ventricular haemodynamics.
abstract: To investigate the relative influence of pericardial and intrathoracic pressures on left and right ventricular diastolic and systolic pressures two experimental groups were studied: group 1-10 open chest dogs with a controlled pericardial effusion; and group 2 - five closed chest dogs with a controlled pneumothorax at constant transpulmonary pressure and lung volume. In both groups right and left ventricular diastolic pressures were linear functions of external pressure with respective slopes of 0.71 and 0.39 for group 1 and 0.80 and 0.78 for group 2. The left ventricular slope of 0.39 indicates that left ventricular volume decreased more with increments in pericardial pressure since a slope of approximately 1.00 would be expected if the filling volume was invariant. Accordingly, the fall in left ventricular systolic pressure that occurred in both groups was two to three times greater in group 1. Right ventricular systolic pressure fell in group 1 whereas it increased in group 2. It is concluded that there are no major differences between the influence of either type of external pressure on right ventricular filing. In contrast, the left ventricle, and in particular the filling pressure gradient between the pulmonary circulation and the left ventricle, is more sensitive to pericardial pressure.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D003971:Diastole; D004285:Dogs; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology*; D006439:Hemodynamics; D010496:Pericardium / Q000502:physiology*; D010994:Pleura / Q000502:physiology; D011312:Pressure; D013909:Thorax / Q000502:physiology*; D016276:Ventricular Function