Increase of 14C-leucine uptake following stimulation of renal tubular transport processes.
Following treatment with cyclopenthiazide, triiodothyronine or dexamethasone the renal excretion of p-aminohippurate (PAH) as well as the accumulation of PAH in renal cortical slices from adult rats and from rats with immature kidney function are increased. There are differences with respect to the age of the rats as well as in dependence on the substance used for treatment. In 10- and 60-day-old rats the [14C]leucine uptake following such a stimulation of kidney function is increased, that means active tubular transport of amino acids can also be stimulated. Furthermore, the [14C]leucine content in the protein fraction of homogenized kidney tissue is increased, indicating a higher degree of incorporation of amino acids in kidney tissue following treatment with cyclopenthiazide, triiodothyronine or dexamethasone.
D000818:Animals; D001692:Biological Transport; D003518:Cyclopenthiazide / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014284:Triiodothyronine / Q000494:pharmacology; D010130:p-Aminohippuric Acid / Q000378:metabolism
D014284:Triiodothyronine; D003907:Dexamethasone; D007930:Leucine; D003518:Cyclopenthiazide; D010130:p-Aminohippuric Acid