Chiral discrimination in the exchange of alpha-tocopherol stereoisomers between plasma and red blood cells.
The transport of 2R,4'R,8'-alpha-tocopherol and 2S,4'R,8'R-alpha-tocopherol from plasma into rat red blood cell membranes occurs with essentially no chiral discrimination. The previously demonstrated (10) preference of red blood cell membranes favoring 2R,4'R,8'R-alpha-tocopherol over the 2S,4'R,8'R stereoisomer is shown to be due to better retention of the former compound, i.e., to preferential retention of natural vitamin E.
D000818:Animals; D003903:Deuterium; D004912:Erythrocytes / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014810:Vitamin E / Q000097:blood*
D014810:Vitamin E; D003903:Deuterium