title: [Epidermolysis bullosa hereditaria dystrophica (Hallopeau-Siemens). Case report and therapy trial with (+)-cyanidanol-3 in 3 patients].
abstract: The diagnosis of hereditary epidermolysis bullosa dystrophica (Hallopeau-Siemens) in three patients was confirmed by clinical and histological means as well as by electron microscopy. The clinical course was followed for many years. Since (+)-cyanidanol-3 has been shown to reduce the susceptibility of collagen to mammalian collagenase under in vitro conditions, (+)-cyanidanol-3 was used to treat the three patients for a period of 27 weeks. A decrease in the amount of blistering was observed in all three patients.
authors: Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
authors: V
authors: V
authors: Schurig
authors: T
authors: T
authors: Krieg
authors: M
authors: M
authors: Landthaler
authors: O
authors: O
authors: Braun-Falco
mesh_terms: D000328:Adult; D002392:Catechin / Q000008:administration & dosage*; D002648:Child; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004820:Epidermolysis Bullosa / Q000188:drug therapy* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D002392:Catechin
vernacular_title: Epidermolysis bullosa hereditaria dystrophica (Hallopeau-Siemens). Fallbericht und Therapieversuch mit (+)-Cyanidanol-3 bei drei Patienten.