Formation of diazopeptides by nitrogen oxides.
A versatile synthesis of diazopeptides is reported and several new compounds described. It is shown that diazopeptides form readily from gaseous nitrogen dioxide in both neutral buffers and human blood. In these media, diazopeptides are sufficiently stable (half-time 0.5-30 h) to qualify as potential circulating carcinogens.
Challis
B C
BC
Chemistry Department, Imperial College, London, United Kingdom.
Fernandes
M H
MH
Glover
B R
BR
Latif
F
F
D001769:Blood; D002021:Buffers; D003979:Diazonium Compounds / Q000138:chemical synthesis / Q000378:metabolism*; D006801:Humans; D008970:Molecular Weight; D009589:Nitrogen Oxides / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet
D002021:Buffers; D003979:Diazonium Compounds; D009589:Nitrogen Oxides; D010455:Peptides