cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.
Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is very similar to human plasminogen. It contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is present in 37 copies.
McLean
J W
JW
Department of Cardiovascular Research, Genentech, Inc., South San Francisco, California 94080.
Tomlinson
J E
JE
Kuang
W J
WJ
Eaton
D L
DL
Chen
E Y
EY
Fless
G M
GM
Scanu
A M
AM
Lawn
R M
RM
D000595:Amino Acid Sequence; D001054:Apolipoproteins A / Q000235:genetics*; D001483:Base Sequence; D005075:Biological Evolution; D004247:DNA / Q000302:isolation & purification*; D006801:Humans; D008969:Molecular Sequence Data; D010958:Plasminogen / Q000235:genetics*; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid
D001054:Apolipoproteins A; D010958:Plasminogen; D004247:DNA