The hepatitis B carrier state--a follow-up study of 100 consecutive cases.
The clinical, demographic, serologic, and histopathologic features of 100 consecutive patients with chronic hepatitis B were studied. The subjects were from diverse racial backgrounds; 59 had emigrated to Canada from geographical areas with high hepatitis B carrier rates. A reduced 5-year survival rate was seen only in those with cirrhosis; death was most commonly related to sepsis. The male to female ratio was 4.0 in the total study group but was higher in those with elevated transaminases (6.0 vs 2.0, p less than 0.05). Those patients with mild-to-heavy alcohol consumption were more likely to have elevated transaminase values than those who drank no alcohol (p less than 0.05). The mean annual sero-conversion rate from HBeAg to Anti-HBe was 8.0%. The HBeAg status did not correlate with the presence of histologic activity or fibrosis.
Kim
Y I
YI
Department of Gastroenterology, Toronto Western Hospital, University of Toronto, Ontario, Canada.
Heathcote
J
J
Wanless
I R
IR
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000502:physiology; D002353:Carrier State; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000201:enzymology / Q000276:immunology / Q000401:mortality* / Q000473:pathology; D006510:Hepatitis B Antibodies / Q000096:biosynthesis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006513:Hepatitis B e Antigens / Q000032:analysis / Q000276:immunology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D000637:Transaminases / Q000097:blood
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D000637:Transaminases