Effects of magnesium chloride on cardiovascular hemodynamics in the neurally intact dog.
To assess the cardiovascular actions of magnesium in neurally intact animals, magnesium chloride (1-4 mM/min) administered i.v., producing a peak arterial magnesium level between 4.7 and 7.2 mg/dl, was given to alpha-chloralose-anesthetized, open-chest dogs. Magnesium lowered heart rate by 36 +/- 11 beats/min (P less than .05), cardiac output by 0.7 +/- 0.2 liters/min (P less than .05), left ventricular (LV) peak dP/dt by 410 +/- 96 mm Hg/sec (P less than .05) and aortic and pulmonary artery pressures, but it did not change LV end-diastolic pressure, systemic resistance or pulmonary resistance. Coronary blood flow also decreased by 39 +/- 11% (P less than .05), myocardial oxygen consumption by 88 +/- 22% (P less than .05) and myocardial oxygen extraction by 53 +/- 16% (P less than .05). When heart rate was held constant, magnesium still decreased LV systolic pressure, LV peak dP/dt and coronary blood flow. The increase in serum magnesium was accompanied by an increase in serum calcium (by 1.4 +/- 0.2 mg/dl; P less than .05) and a fall in serum potassium (by 0.21 +/- 0.1 mEq/l), but not by a change in serum sodium, myocardial electrolyte arteriovenous differences or arterial pH. Thus, at blood concentrations that are observed in humans after therapeutic dosages of magnesium, a depression of cardiac performance is observed in the anesthetized dog. Although magnesium produces a fall in coronary blood flow, this appears to be due at least in part to a decrease in myocardial oxygen requirements because myocardial oxygen extraction also decreases. Rapid changes in serum electrolytes accompany these hemodynamic effects.
Friedman
H S
HS
Department of Medicine, State University of New York Health Science Center, Brooklyn.
Nguyen
T N
TN
Mokraoui
A M
AM
Barbour
R L
RL
Murakawa
T
T
Altura
B M
BM
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D006329:Heart Conduction System / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007262:Infusions, Intravenous; D008274:Magnesium / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D015636:Magnesium Chloride; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D011652:Pulmonary Circulation / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D015636:Magnesium Chloride; D008274:Magnesium