The effect of a lipid suspension on amitriptyline disposition.
A 5-h infusion of a lipid suspension or saline was given on separate occasions to four healthy volunteers taking amitriptyline. Mean plasma levels of amitriptyline plus nortriptyline were 14% higher at the end of the lipid infusion but the difference was not statistically significant. Infusion of a lipid suspension is unlikely to materially affect the severity of amitriptyline intoxication.
Minton
N A
NA
Poisons Unit, Guy's Hospital, London, UK.
Goode
A G
AG
Henry
J A
JA
D000328:Adult; D000639:Amitriptyline / Q000097:blood / Q000493:pharmacokinetics*; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009661:Nortriptyline / Q000097:blood; D014280:Triglycerides / Q000097:blood
D005217:Fat Emulsions, Intravenous; D014280:Triglycerides; D000639:Amitriptyline; D009661:Nortriptyline