[Effect of dibunol and isoptin on the creatine kinase and myoglobin content of the blood serum in dogs undergoing postischemic coronary reperfusion].
The effect of an antioxidant dibunol and calcium antagonist verapamil on postperfusion release of myoglobin (Mb) and MB-creatine kinase (MB-CK) has been assessed in 30 dogs with experimental coronary occlusive myocardial infarction. It has been shown that reperfusion after 3-hour ischemia does not only accelerate the release of intracellular proteins, but also leads to pronounced myoglobinemia and blood enzymes. In postischemic blood flow recovery with combined dibunol and verapamil preliminary injections, an almost threefold decrease in MB-CK and Mb blood content, as compared to "reperfusion" indexes, was observed by the 10th minute of reperfusion.
Golikov
A P
AP
Avilova
O A
OA
Polumiskov
V Iu
VIu
Berestov
A A
AA
Konorev
E A
EA
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy*; D003402:Creatine Kinase / Q000097:blood*; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D007527:Isoenzymes; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy; D009211:Myoglobin / Q000097:blood*; D013997:Time Factors; D014700:Verapamil / Q000627:therapeutic use*
D000975:Antioxidants; D002121:Calcium Channel Blockers; D007527:Isoenzymes; D009211:Myoglobin; D002084:Butylated Hydroxytoluene; D014700:Verapamil; D003402:Creatine Kinase
Vliianie dibunola i izoptina na soderzhanie kreatinkinazy i mioglobina v syvorotke krovi sobak pri postishemicheskoĭ koronarnoĭ reperfuzii.