title: A myeloproliferative disease in two infants associated with eosinophilia and chromosome t(1;5) translocation.
abstract: Two children are described who presented at the age of 5 and 7 months with anaemia, a high white cell count with eosinophilia and thrombocytopenia. Both children had an identical balanced translocation t(1;5)(q23;q33) and no evidence of a constitutional abnormality. The response to treatment of one child was poor, the other remains well on therapy. This translocation has not been previously reported and is likely to represent a subclass of myeloproliferative disorder analogous to the monosomy 7 syndrome, although less common. The previous literature of acquired chromosome abnormalities involving chromosomes 1 and 5 is reviewed.
authors: Department of Haematology/Oncology, Hospital for Sick Children, London.
authors: P J
authors: PJ
authors: Darbyshire
authors: D
authors: D
authors: Shortland
authors: G J
authors: GJ
authors: Swansbury
authors: J
authors: J
authors: Sadler
authors: S D
authors: SD
authors: Lawler
authors: J M
authors: JM
authors: Chessells
mesh_terms: D002878:Chromosomes, Human, Pair 1 / Q000648:ultrastructure*; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure*; D004802:Eosinophilia / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D009196:Myeloproliferative Disorders / Q000235:genetics*; D014178:Translocation, Genetic