The influence of altered tryptophan availability on ethanol intoxication in normal men.
Because of evidence that altered 5-hydroxytryptamine function may modulate ethanol intoxication, we investigated this in normal social drinkers. Using amino acid mixtures, 5-hydroxytryptamine was influenced by altering levels of its precursor tryptophan. Neither raising nor lowering tryptophan affected alcohol intoxication as measured by a self-report scale and memory and motor tasks. Our data do not support the idea that 5-hydroxytryptamine can modulate alcohol-induced intoxication.
Zacchia
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Department of Psychology, McGill University, Montreal, Canada.
Pihl
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Young
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S
Ervin
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FR
D000293:Adolescent; D000328:Adult; D000339:Affect / Q000187:drug effects*; D000435:Alcoholic Intoxication / Q000097:blood / Q000523:psychology*; D000431:Ethanol / Q000097:blood; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D011597:Psychomotor Performance / Q000187:drug effects*; D014364:Tryptophan / Q000008:administration & dosage* / Q000097:blood; D014706:Verbal Learning / Q000187:drug effects
D000431:Ethanol; D014364:Tryptophan