[Correction of arterial pressure in rats with hereditary hypertension by altering catecholamine metabolism in early ontogeny].
In a newly developed rat strain with inherited stress-sensitive arterial hypertension (ISSAH) an attempt was made to reduce arterial blood pressure by L-DOPA injections during a short time period of the early ontogenesis. It was shown that L-DOPA injections to rats on days 7-9 or 14-16 of life had no effect. The same procedure performed on 21-23 or 21-25-day-old rats was followed by a decrease in the basal and stress-induced arterial blood pressure levels, measured in adulthood. Injections of dopamine-beta-hydroxylase inhibitor (FLA-59) with parallel L-DOPA administration completely blocked the blood pressure decreasing effect. It can be suggested that injections of L-DOPA in the 4th week of post-natal life reduce the blood pressure level in ISSAH rats by enhancing the rate of brain noradrenaline biosynthesis.
Naumenko
E V
EV
Maslova
L N
LN
Markel'
A L
AL
Gordienko
N I
NI
D000375:Aging / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism*; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors; D006973:Hypertension / Q000503:physiopathology*; D007980:Levodopa / Q000493:pharmacokinetics; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*
D002395:Catecholamines; D007980:Levodopa; D004299:Dopamine beta-Hydroxylase
Korrektsiia arterial'nogo davleniia u krys s nasledstvennoĭ gipertenzieĭ putem izmeneniia metabolizma katekholaminov v rannem ontogeneze.