Experimental irradiation of the rat ureter: the effects of field size and the presence of contrast medium on incidence and latency of hydronephrosis.
Following X-irradiation of a 1.5 cm length of rat ureter, hydronephrosis developed after doses down to 10 Gy. The estimated ED50 was 11.8 Gy. In the dose range 37.4 Gy to 17.5 Gy there was a significant increase in latency with decreasing dose, but at lower doses the latency did not increase further. Reducing the length of ureter irradiated to 0.5 cm or 0.8 cm caused a decrease in incidence of hydronephrosis and longer latency periods. The ED50 for rats irradiated to 0.5 cm of ureter was 29.6 Gy. The possibility that secondary radiation produced as a result of interaction between X-radiation and iodinated contrast medium might affect the radiation induction of hydronephrosis was investigated. No difference was found between groups of rats irradiated with or without injection of contrast media.
Knowles
J F
JF
Medical College of St. Bartholomews Hospital, London, U.K.
Trott
K R
KR
D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006869:Hydronephrosis / Q000209:etiology*; D007472:Iohexol / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000209:etiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014513:Ureter / Q000528:radiation effects*; D014567:Urography
D003287:Contrast Media; D007472:Iohexol