Occurrence of circulating 7-deoxyaglycone metabolites of 4'-deoxydoxorubicin in man.
In five cancer patients we have determined the pharmacokinetics of 4'-deoxydoxorubicin (4'-DOX), its alcoholic metabolite 4'-deoxydoxorubicinol and the occurrence of circulating 7-deoxyaglycone metabolites. The 7-deoxyaglycone of the alcohol metabolite, the major aglycone of Adriamycin (ADR) present in man, was not detected in any serum sample. The 7-deoxyaglycone of the parent drug, which appears in concentrations in excess of 30 ng/ml after ADR administration, was detected in only 2/5 patients in trace amounts. These preliminary data indicate a difference in biotransformation between ADR and 4'-DOX despite their close structural similarities.
Cummings
J
J
Department of Medical Oncology, University of Glasgow, Scotland.
Kerr
D J
DJ
Kaye
S B
SB
D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D006207:Half-Life; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy; D008297:Male; D009279:Naphthacenes / Q000097:blood
D009279:Naphthacenes; C010012:adriamycin aglycone; D004317:Doxorubicin; C046579:4'-deoxydoxorubicinol; C030851:esorubicin; C049326:7-deoxyadriamycin aglycone