title: Differences in surface molecules of motor axon terminals correlated with cell-cell recognition.
abstract: The cell-cell interactions leading to the formation of synaptic connections among cells in the nervous system may be mediated by cell surface macromolecules. In the cockroach the specific reformation of the original innervation pattern of a set of leg muscles during axonal regeneration indicates a significant contribution from cell-cell recognition. Macromolecules mediating such a process would be expected to be distributed differentially among the axon terminals of the various motor neurons. Monoclonal antibodies have been isolated that selectively bind to the surfaces of axon terminals of some motor neurons and not others. Preliminary biochemical characterization indicates that these antigens are glycoproteins and are good candidates for consideration as recognition macromolecules.
authors: Biology Department, University of Iowa, Iowa City 52242.
authors: J L
authors: JL
authors: Denburg
authors: R T
authors: RT
authors: Caldwell
authors: J M
authors: JM
authors: Marner
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D001369:Axons / Q000276:immunology / Q000502:physiology; D002450:Cell Communication; D002462:Cell Membrane / Q000276:immunology / Q000502:physiology; D009046:Motor Neurons / Q000276:immunology / Q000502:physiology*; D009416:Nerve Regeneration; D010526:Periplaneta / Q000502:physiology
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface