title: Macrocytic anaemia due to copper deficiency in a patient with late onset hypogammaglobulinaemia.
abstract: Very few cases of acquired severe copper deficiency have been described. The principal effects are haematological, but the precise abnormalities are uncertain due to the possible association of other deficiencies. A case of isolated severe copper deficiency associated with late onset hypogammaglobulinaemia is reported in which the chief findings were macrocytic anaemia, neutropenia and a decrease in mean platelet volume. All these abnormalities resolved when copper therapy was instituted and recurred when the medication was stopped.
authors: Department of Medicine, Whittington Hospital, London, UK.
authors: S M
authors: SM
authors: Oppenheimer
authors: B I
authors: BI
authors: Hoffbrand
authors: T L
authors: TL
authors: Dormandy
authors: N
authors: N
authors: Parker
authors: D G
authors: DG
authors: Wickens
mesh_terms: D000361:Agammaglobulinemia / Q000150:complications*; D000368:Aged; D000748:Anemia, Macrocytic / Q000188:drug therapy / Q000209:etiology*; D003300:Copper / Q000172:deficiency* / Q000627:therapeutic use; D019327:Copper Sulfate; D005260:Female; D006801:Humans; D013997:Time Factors
chemical_list: D003300:Copper; D019327:Copper Sulfate