title: Analysis of unsaturated fatty acids of endoneurium and perineurium from normal and degenerating rat sciatic nerve. Morphological correlations.
abstract: The major portion of the endoneurial lipids is found in myelin. Since perineurial cells differ morphologically from endoneurial cell components, we attempted to determine whether these morphological differences also extended to a difference in fatty acid (FA) composition. Under normal circumstances, unsaturated FAs are more abundant than saturated ones (55-60% of total FAs) in endoneurium and perineurium. A characteristic biochemical difference between these two structures lies in the distribution of linoleic acid (C18:2(n-6)) which represents 20% of total FAs in perineurium and only 2% in endoneurium. Wallerian degeneration takes place after injection of pure glycerol into the endoneurium. This is followed by regeneration characterized by a proliferation of perineurial cells infiltrating the center of the nerve fascicule forming microcompartments. The changes in linoleic acid content reflect these morphological changes. A marked increase in linoleic acid is detected in the endoneurial fraction in parallel with the observed infiltration of perineurial cells into the nerve fascicule.
authors: Department of Neurology, University Hospital, Limoges, France.
authors: C
authors: C
authors: Fressinaud
authors: J M
authors: JM
authors: Vallat
authors: M
authors: M
authors: Rigaud
authors: M J
authors: MJ
authors: Leboutet
mesh_terms: D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005990:Glycerol; D008297:Male; D009410:Nerve Degeneration; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D014855:Wallerian Degeneration
chemical_list: D005231:Fatty Acids, Unsaturated; D005990:Glycerol