Some pharmacokinetic data about furaltadone and nitrofurazone administered orally to preruminant calves.
A single oral dosage of furaltadone and nitrofurazone (14.0 mg/kg) to 5 preruminant calves (in a cross-over trial) revealed mean maximum plasma concentration of 2.5 and 3.5 microgram/ml, respectively, at approximately 3 h after administration. The final elimination half-lives of furaltadone and nitrofurazone were 2.5 and 5 h, respectively. Urinary recovery of these two nitrofurans in 3 calves revealed approximately 2% of the orally administered dose. The renal clearance of the unbound drugs did not differ (for both drugs approximately 0.42 ml/min/kg); furaltadone clearance was strongly related to urine flow.
Nouws
J F
JF
Department of Clinical Pharmacy, Sint Radboud Hospital, Nijmegen, The Netherlands.
Vree
T B
TB
Aerts
M M
MM
Degen
M
M
Driessens
F
F
D000284:Administration, Oral / Q000662:veterinary; D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D002417:Cattle / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D006207:Half-Life; D008297:Male; D009581:Nitrofurans / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D009583:Nitrofurazone / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D023303:Oxazolidinones
D000892:Anti-Infective Agents, Urinary; D009581:Nitrofurans; D023303:Oxazolidinones; C007795:furaltadon; D009583:Nitrofurazone