[Isolated perfusion of the small intestine of the rat with perfluorotributylamine as an artificial oxygen carrier].
A new model of isolated intestinal perfusion could be established with fluorocarbon (FC-43) as artificial oxygen carrier. Morphology, cell metabolism of xenobiotics (phase I and II), as well as the transport of a monosaccharide, were stable for at least 2 h. Without interference with the changing metabolism of erythrocytes in the perfusion medium, the proposed model allows one to investigate exclusively the metabolic function of the perfused organ.
Hartmann
F
F
Med. Univ. Klinik Tübingen, Abt. Innere Medizin I.
Plauth
M
M
Vieillard-Baron
D
D
Bauder
D
D
D000818:Animals; D004734:Energy Metabolism; D005466:Fluorocarbons; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000098:blood supply* / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D010477:Perfusion; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats
D005466:Fluorocarbons; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; C008807:perfluorotributylamine; D019289:Pyruvic Acid; D010100:Oxygen
Isolierte Perfusion des Rattendünndarms mit Perfluorotributylamin als künstlichem Sauerstoffträger.