title: Hyperplastic acral keratoses--association with invasive squamous cell carcinoma.
abstract: We have observed hyperplastic epidermal lesions in sun-damaged skin on the backs of the hands, wrists, and forearms that, in some examples, contain foci of invasive squamous cell carcinoma. Atypia in these lesions is focal or absent. Because of their bland histology, physicians are likely to interpret small or superficial biopsies as indicating a benign lesion. However, careful clinical correlation and follow-up are recommended, as residual tissue may contain invasive carcinoma or its precursor.
authors: Department of Pathology, University of Utah Medical Center, Salt Lake City 84132.
authors: M S
authors: MS
authors: Rabkin
authors: W S
authors: WS
authors: Weems
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D006229:Hand Dermatoses / Q000150:complications* / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D007642:Keratosis / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology