Sickle cell crisis following intraarticular steroid therapy for rheumatoid arthritis.
We describe 2 patients who had coexistent rheumatoid arthritis and sickle cell disease. Both patients developed sickle cell crises following intraarticular injection of corticosteroids to control their arthritis. The mechanism of this phenomenon is not clear, but it is suggested that intraarticular steroids be used with caution in patients with sickle cell disease.
Gladman
D D
DD
Rheumatic Disease Unit, University of Toronto, Wellesley Hospital, Ontario, Canada.
Bombardier
C
C
D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000328:Adult; D000755:Anemia, Sickle Cell / Q000139:chemically induced* / Q000175:diagnosis; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D008875:Middle Aged; D012008:Recurrence
D000305:Adrenal Cortex Hormones