[Pharmacokinetics of cefpiramide concentration in lung tissues].
Concentrations of cefpiramide (CPM) in human lung tissues were determined after 1 g intravenous bolus injection in 6 patients with lung tumors and pyothorax. Concentrations of the CPM in blood and lung tissues were determined and analyzed pharmacokinetically. Levels of CPM in the lung tissues reached 38.4 micrograms/g at 2 hours and declined to 27.7 micrograms/g in 6 hours. Levels of CPM in the lung tissues were higher than 50% of those in the serum between 100 minutes and 360 minutes after the administration of CPM.
Ikeda
T
T
Department of Surgery, Tokyo Metropolitan Komagome Hospital.
Sakai
T
T
Nishimura
Y
Y
D000328:Adult; D000368:Aged; D002511:Cephalosporins / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D002511:Cephalosporins; C036666:cefpiramide