The effect of ethanol and haloperidol on dopamine receptor (D2) density.
The study was performed to investigate the influence of ethanol on haloperidol-induced changes of the dopamine (D2) receptors in rat striatal membrane preparations. Subchronic administration of the neuroleptic in the drinking water resulted in an increase of the number of binding sites in a dose-dependent manner. Simultaneous treatment with both haloperidol and ethanol prevented the rise of D2 receptors.
Fuchs
V
V
Department of Neuropsychopharmacology, Free University, Berlin, F.R. Germany.
Coper
H
H
Rommelspacher
H
H
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D013134:Spiperone / Q000378:metabolism
D011954:Receptors, Dopamine; D000431:Ethanol; D013134:Spiperone; D006220:Haloperidol