New tylosin analogs produced by mutants of Streptomyces fradiae.
2'''-Demethoxytylosin (component IIIc), 2'''-demethoxy-4'''-epi-tylosin (component IIId) and 2'''-O-demethyltylosin (component Vb) were produced by blocked mutant strains of Streptomyces fradiae. Fermentation, isolation, structure determination and biosynthetic considerations of these tylosin analogs are described.
Kiyoshima
K
K
Sanraku Inc., Central Research Laboratories, Fujisawa, Japan.
Takada
K
K
Yamamoto
M
M
Kubo
K
K
Okamoto
R
R
Fukagawa
Y
Y
Ishikura
T
T
Naganawa
H
H
Sawa
T
T
Takeuchi
T
T
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D007933:Leucomycins / Q000096:biosynthesis; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009154:Mutation; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*; D013329:Structure-Activity Relationship; D015645:Tylosin
D007933:Leucomycins; D015645:Tylosin