Micronucleus test in bone marrow of mice treated with 1-nitropropane, 2-nitropropane and cisplatin.
Micronucleus tests were carried out in bone marrow of mice treated with 1-nitropropane, 2-nitropropane and cisplatin. For 1-nitropropane and 2-nitropropane the results were negative. With cisplatin a dose-dependent increase in the number of polychromatic erythrocytes with micronuclei was observed. The lowest positive dose was 0.1 mg/kg (P less than 0.001, Mann-Whitney-Wilcoxon test). The hepatocarcinogen 2-nitropropane showed clastogenic activity in human lymphocytes in vitro in the presence of S9 (Bauchinger et al., 1987). The negative results in bone marrow suggest that short-lived genotoxic metabolites may be formed in the liver but do not reach the bone marrow.
Kliesch
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Institute of Mammalian Genetics, Society for Radiation and Environmental Research, Neuherberg, F.R.G.
Adler
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ID
D000473:Alkanes / Q000633:toxicity*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002467:Cell Nucleus / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002945:Cisplatin / Q000633:toxicity*; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D009595:Nitroparaffins / Q000633:toxicity*; D011407:Propane / Q000031:analogs & derivatives* / Q000633:toxicity
D000473:Alkanes; D009153:Mutagens; D009595:Nitroparaffins; C035314:1-nitropropane; C016617:2-nitropropane; D002945:Cisplatin; D011407:Propane