Effect of inhibin on testosterone metabolism by rat ventral prostate in vitro.
Conversion of radiolabeled testosterone to 5 alpha-dihydrotestosterone (5 alpha-DHT) was determined in the rat ventral prostate in vitro, and the effect of inhibin on this conversion was demonstrated. The data revealed that the reduction of testosterone to 5 alpha-DHT was inhibited in a dose-related manner in the presence of inhibin as compared with the basal reduction. The percentage of testosterone reduced per 10-mg tissue also showed a similar trend. The ratio of radioactive counts for DHT and testosterone was also minimum at the highest dose of inhibin used. Inhibin can thus modulate the conversion of testosterone to 5 alpha-DHT in the rat ventral prostate, and therefore can autocrine-paracrine function can be attributed to the prostate.
Joseph
R
R
Institute for Research in Reproduction, Bombay, India.
Maitra
A
A
Moodbidri
S B
SB
Sheth
A R
AR
D058891:5-alpha Reductase Inhibitors; D000818:Animals; D013196:Dihydrotestosterone / Q000378:metabolism; D007265:Inhibins / Q000494:pharmacology*; D008297:Male; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013739:Testosterone / Q000378:metabolism*
D058891:5-alpha Reductase Inhibitors; D013196:Dihydrotestosterone; D013739:Testosterone; D007265:Inhibins