title: Evaluation of 13N-amines as tracers.
abstract: The organ distribution and the metabolic fate of the 13N-amines 13N-beta-phenethylamine, 13N-n-octylamine, and 13N-3,4-dimethoxyphenethylamine, were studied in detail. After administration 13N-amines were rapidly transferred to tissues and oxidized by MAO. 13N-ammonia formed thereby was converted into amino acids (mainly glutamine by glutamine synthetase) and trapped. 13N-amines were found to be potential metabolic trapping tracers for the study of disposition and metabolism of amines.
authors: Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
authors: T
authors: T
authors: Tominaga
authors: O
authors: O
authors: Inoue
authors: K
authors: K
authors: Suzuki
authors: T
authors: T
authors: Yamasaki
authors: M
authors: M
authors: Hirobe
mesh_terms: D000588:Amines / Q000493:pharmacokinetics*; D000641:Ammonia / Q000493:pharmacokinetics; D000818:Animals; D002250:Carbon Radioisotopes; D004118:Dimethoxyphenylethylamine / Q000493:pharmacokinetics; D007700:Kinetics; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009590:Nitrogen Radioisotopes; D010627:Phenethylamines / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D000588:Amines; D002250:Carbon Radioisotopes; D004118:Dimethoxyphenylethylamine; D009590:Nitrogen Radioisotopes; D010627:Phenethylamines; C029261:phenethylamine; D000641:Ammonia; C008699:octylamine