Is hemisplenectomy a satisfactory option to total splenectomy in abdominal staging of Hodgkin's disease?
The spleens removed in 76 consecutive staging laparotomies for Hodgkin's disease were studied. The spleens were divided from superior to inferior pole into anterior and posterior halves and each half further divided into superior, mid, and inferior sectors. Sectors were studied grossly and microscopically and involvement by Hodgkin's recorded. Of the 23 positive spleens, all sectors were positive in 12, 5 sectors positive in 1, 4 sectors in 3, 3 sectors in 3, 2 sectors in 1, and 1 sector in 2. In one spleen, four sectors were involved but were not marked properly to allow identification of which four, and one spleen with fairly diffuse disease was not handled according to protocol, remaining an "indeterminate" positive. From the anatomic distribution, a lower pole hemisplenectomy would have removed disease in 22 of 23 spleens and likely would have shown disease in the diffusely involved "indeterminate" spleen. An upper pole hemisplenectomy would have missed disease in one spleen and possibly in the "indeterminate" spleen. Either approach would have missed disease in around 1% of the 76 cases. The addition of a biopsy of the opposite pole that remains is technically feasible and would reduce this small incidence of undetected abdominal disease. With the increasing appreciation of the importance of the immunologic functions of the spleen, alternative techniques for determining splenic involvement have been proposed. From this study, hemisplenectomy appears to be an attractive alternate that preserves the vital functions of the spleen with a minute risk of overlooking the presence of Hodgkin's disease.
Tubbs
R R
RR
Department of Pathology, Cleveland Clinic Foundation, OH 44106.
Thomas
F
F
Norris
D
D
Firor
H V
HV
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D013156:Splenectomy / Q000379:methods*; D013160:Splenic Neoplasms / Q000473:pathology*