Mesovarian leiomyomas in the rat.
Prolonged treatment with two chemically distinct beta-stimulants, Salbutamol and Terbutaline, resulted in mesovarian leiomyomas in Sprague-Dawley rats. Development of these tumors induced by Salbutamol was prevented by concurrent administration of the beta-blocker Propranolol. Mesovarian leiomyomas induced by Salbutomol did not show any regression or progression during a 44-week postdosing recovery period. This report also gives the first recorded incidence of spontaneous mesovarian leiomyomas in the rat.
Gopinath
C
C
Huntingdon Research Centre, Cambridgeshire, England.
Gibson
W A
WA
D000420:Albuterol / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens; D005260:Female; D007889:Leiomyoma / Q000139:chemically induced* / Q000473:pathology; D008654:Mesothelioma / Q000139:chemically induced* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013726:Terbutaline / Q000633:toxicity*
D002273:Carcinogens; D013726:Terbutaline; D000420:Albuterol