Environmental exposure of primary care personnel to ribavirin aerosol when supervising treatment of infants with respiratory syncytial virus infections.
The potential exposure to ribavirin aerosol in the environment was assessed in nurses caring for infants and children with severe lower respiratory tract infections due to respiratory syncytial virus. Ribavirin aerosol was administered via a ventilator, oxygen tent, or oxygen hood. Participants worked directly with infants receiving ribavirin for 20.0 to 35.0 h over a 3-day period. No toxic or adverse effects of ribavirin aerosol were observed in any of the 19 nurses studied, and ribavirin was not detected in erythrocytes, plasma, or urine collected after the potential exposure period.
Rodriguez
W J
WJ
Children's Hospital National Medical Center, George Washington University School of Medicine and the Health Sciences, Washington, D.C. 20010.
Bui
R H
RH
Connor
J D
JD
Kim
H W
HW
Brandt
C D
CD
Parrott
R H
RH
Burch
B
B
Mace
J
J
D000328:Adult; D000336:Aerosols; D004781:Environmental Exposure; D004912:Erythrocytes / Q000032:analysis / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D009726:Nurses; D010102:Oxygen Inhalation Therapy; D012136:Respiratory Syncytial Viruses; D010253:Respirovirus Infections / Q000188:drug therapy*; D012254:Ribavirin / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use; D012263:Ribonucleosides / Q000008:administration & dosage*
D000336:Aerosols; D012263:Ribonucleosides; D012254:Ribavirin