Inhibitory effect of almitrine on dopaminergic activity of rat carotid body.
Almitrine increases ventilation by stimulating the peripheral arterial chemoreceptors. This study assessed the effects of acute and chronic almitrine treatments on the dopamine (DA) and norepinephrine (NE) contents and utilization rates in the rat carotid body. Almitrine (5 mg/kg ip) caused a 34% reduction in DA content after 30 min. Extending the almitrine treatment for 15 days (one daily ip injection) produced a further progressive diminution in DA stores (-55%; P less than 0.01). The utilization rate of DA measured after inhibiting catecholamine biosynthesis by alpha-methyl-p-tyrosine was strongly reduced by almitrine (-98% after 15 days; P less than 0.01). The effects of almitrine were dose dependent. The noradrenergic activity was much less altered by the drug. The data showed that almitrine can modify the dynamics of DA in rat carotid body producing a decrease in both content and utilization rate.
Pequignot
J M
JM
Centre National de la Recherche Scientifique, Laboratoire de Physiologie, Faculté de Médecine Grange-Blanche, Lyon, France.
Tavitian
E
E
Boudet
C
C
Evrard
Y
Y
Claustre
J
J
Peyrin
L
L
D015765:Almitrine; D000818:Animals; D002344:Carotid Body / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D018492:Dopamine Antagonists; D004305:Dose-Response Relationship, Drug; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects
D018492:Dopamine Antagonists; D010879:Piperazines; D015765:Almitrine; D004298:Dopamine; D009638:Norepinephrine