title: Alterations in [3H]desmethylimipramine binding in the aged rat brain: an in vitro autoradiographic demonstration.
abstract: Using in vitro autoradiographic receptor binding, the present report provides a descriptive analysis of [3H]desmethylimipramine ([3H]DMI) binding in the aged rat brain. Small circular patches of intense [3H]DMI binding were present within the caudate nucleus in every aged brain examined. Occasionally, similar patches of label were present in restricted cortical regions of aged brains. Comparable patches of [3H]DMI binding were never observed in young brains used in these investigations. Additional evidence suggests that these age-dependent changes in [3H]DMI binding are anatomically restricted to the loci indicated above.
authors: University of North Carolina at Chapel Hill, Department of Psychology 27514.
authors: P R
authors: PR
authors: Rapp
authors: R F
authors: RF
authors: Fanelli
authors: M
authors: M
authors: McGuire
authors: R A
authors: RA
authors: Rosenberg
authors: M
authors: M
authors: Gallagher
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D002421:Caudate Nucleus / Q000254:growth & development / Q000378:metabolism; D003342:Corpus Striatum / Q000254:growth & development / Q000378:metabolism; D003891:Desipramine / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats
chemical_list: D003891:Desipramine