Resting energy expenditure of host and tumor is similar in rats with methylcholanthrene-induced sarcoma.
In the present study we assessed the resting energy expenditure of 30 free-feeding control and methylcholanthrene-induced sarcoma-bearing rats prior to and following surgical removal of the tumor. Tumor-bearing rats demonstrated carcass wasting and massive tumor growth. The resting energy expenditure data in our model suggest that neither the presence and growth of a tumor nor its removal significantly change resting energy expenditure beyond the normal range for non-tumor-bearing rats. We suggest that in the partition of energy costs between host and tumor, both carry a similar input, proportional to their relative weight, into the total combined resting energy expenditure of host and tumor.
Freund
H R
HR
Department of Surgery, University of Cincinnati Medical Center, OH 45267.
Kim
M W
MW
Muggia-Sullam
M
M
Chance
W T
WT
Fischer
J E
JE
D000818:Animals; D004734:Energy Metabolism; D008748:Methylcholanthrene; D009929:Organ Size; D051381:Rats; D011916:Rats, Inbred F344; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D013997:Time Factors
D008748:Methylcholanthrene