title: Monocyte esterase? A factor involved in the pathogenesis of lymphoproliferative neoplasia.
abstract: Monocyte esterase activity was studied in 1,000 doctor-attending patients with normal hematological indices and in 56 patients with non-Hodgkin's lymphoma (NHL) or B chronic lymphocytic leukemia (CLL). The incidence of esterase deficiency was significantly greater in the NHL-CLL patients (7.1%) than in the population group (1.7%; p less than 0.05). In the NHL-CLL group, study of the families showed the esterase deficiency to be a familial characteristic. We postulate that the presence of the anomaly may be either a factor predisposing to the development of the NHL or CLL or a factor indicating a predisposition to these disorders.
authors: Haematology Department, Belfast City Hospital, Northern Ireland.
authors: G M
authors: GM
authors: Markey
authors: T C
authors: TC
authors: Morris
authors: H D
authors: HD
authors: Alexander
authors: A
authors: A
authors: Kyle
authors: D
authors: D
authors: Middleton
authors: A
authors: A
authors: Turner
authors: P
authors: P
authors: Burnside
authors: H G
authors: HG
authors: Drexler
authors: G
authors: G
authors: Gaedicke
authors: W
authors: W
authors: Hartmen
mesh_terms: D004950:Esterases / Q000097:blood*; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D007945:Leukemia, Lymphoid / Q000201:enzymology / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology / Q000235:genetics; D008232:Lymphoproliferative Disorders / Q000201:enzymology* / Q000235:genetics; D009000:Monocytes / Q000201:enzymology*; D010375:Pedigree
chemical_list: D007527:Isoenzymes; D004950:Esterases