title: Effect of PSK on prohibited immunity of splenectomized mice.
abstract: The effect of PSK (Krestine, an anti-tumor drug prepared from Coriolus versicolor) on splenectomized experimental animals was investigated. Splenectomy was performed on both a tumor-free control group and a tumor-bearing group. The administration of PSK on the splenectomized control group significantly increased the immune state of the host. In the case of the tumor-bearing group, administration of PSK resulted in restoration of the immune function as observed in the control group. Recovery of the immunological function was accelerated when tumor-bearing animals were splenectomized at the terminal stage. The results suggest that the immunomodulating effects of PSK developed at the time of the splenectomy resulted in anticancer activity.
authors: Kureha Chemical Industry Co., Ltd. Biomedical Research Laboratories, Tokyo, Japan.
authors: T
authors: T
authors: Fujii
authors: T
authors: T
authors: Kano
authors: K
authors: K
authors: Saito
authors: Y
authors: Y
authors: Kobayashi
authors: H
authors: H
authors: Iijima
authors: T
authors: T
authors: Matsumoto
authors: C
authors: C
authors: Yoshikumi
authors: T
authors: T
authors: Taguchi
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects*; D051379:Mice; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000628:therapy; D010853:Picryl Chloride; D011509:Proteoglycans / Q000494:pharmacology*; D012513:Sarcoma, Experimental / Q000276:immunology / Q000628:therapy; D013156:Splenectomy; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D011509:Proteoglycans; C010770:polysaccharide-K; D010853:Picryl Chloride