title: Mode of action of antiprotozoan agents. Electron transfer and oxy radicals.
abstract: Cyclic voltammetry data were obtained for most of the main classes of antiprotozoan agents, specifically, nitroheterocycles, quinones, metal complexes and derivatives, iminium-type ions, and azo compounds. The reductions were generally reversible in the range of -0.3 to -0.9 V. Catalytic production of oxidative pressure from redox cycling involving oxygen is believed to be an important mode of action by the medicinal agents. Literature data contribute support.
authors: Department of Chemistry, University of Wisconsin-Milwaukee 53201.
authors: J R
authors: JR
authors: Ames
authors: M D
authors: MD
authors: Ryan
authors: P
authors: P
authors: Kovacic
mesh_terms: D000981:Antiprotozoal Agents / Q000494:pharmacology*; D001391:Azo Compounds / Q000494:pharmacology; D002614:Chelating Agents / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004579:Electron Transport; D005609:Free Radicals; D007097:Imines / Q000494:pharmacology; D010084:Oxidation-Reduction; D011809:Quinones / Q000494:pharmacology
chemical_list: D000981:Antiprotozoal Agents; D001391:Azo Compounds; D002614:Chelating Agents; D005609:Free Radicals; D007097:Imines; D011809:Quinones