Cytogenetics of bone marrow fibroblastic cells in idiopathic chronic myelofibrosis.
To determine the nature of the fibroblastic proliferation in myelofibrosis, we studied the cytogenetic composition of a pure population of in-vitro bone marrow fibroblastic cells (FC) from a patient with idiopathic chronic myelofibrosis who had trisomy 8 in her unstimulated peripheral blood cells. This cytogenetic abnormality was absent in all the FC studied supporting the premise that in the myeloproliferative disorders the myelofibrosis represents a secondary or non-neoplastic reaction to the clonal proliferation of haematopoietic stem cells.
Greenberg
B R
BR
Section of Hematology/Oncology, Veterans Administration Medical Center, Tucson, Arizona 85723.
Woo
L
L
Veomett
I C
IC
Payne
C M
CM
Ahmann
F R
FR
D000368:Aged; D001853:Bone Marrow / Q000648:ultrastructure*; D002478:Cells, Cultured; D002898:Chromosomes, Human, Pair 8; D002908:Chronic Disease; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D007621:Karyotyping; D008854:Microscopy, Electron; D055728:Primary Myelofibrosis / Q000235:genetics*; D014314:Trisomy