title: A novel tetracycline from Actinomadura brunnea. Fermentation, isolation and structure elucidation.
abstract: A novel tetracycline antibiotic, Sch 33256, was isolated from a culture broth of a new species of Actinomadura. The antibiotic was isolated by solvent extraction, Sephadex G-25 column chromatography and crystallization. The structure was determined by comparison of the spectra with that of chlortetracycline. Spectroscopic analysis of the compound yielded 2'-N-methyl-8-methoxychlortetracycline as the proposed structure.
authors: Department of Microbial Products, Schering Corporation, Bloomfield, NJ 07003.
authors: M
authors: M
authors: Patel
authors: V P
authors: VP
authors: Gullo
authors: V R
authors: VR
authors: Hegde
authors: A C
authors: AC
authors: Horan
authors: F
authors: F
authors: Gentile
authors: J A
authors: JA
authors: Marquez
authors: G H
authors: GH
authors: Miller
authors: M S
authors: MS
authors: Puar
authors: J A
authors: JA
authors: Waitz
mesh_terms: D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002751:Chlortetracycline / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D009618:Nocardiaceae / Q000378:metabolism*
chemical_list: C054352:2'-N-methyl-8-methoxychlortetracycline; D002751:Chlortetracycline