title: Expression of an unusual isozyme of lactate dehydrogenase in the serum of cancer patients and comparison with carcinoembryonic antigen.
abstract: Two studies reported here demonstrate a statistically significant association between metastatic cancer and the appearance of the k isozyme of lactate dehydrogenase in serum of affected patients. The first study included 190 coded samples from three types of cancer patients and matched controls; the second included 155 preoperative and 200 postoperative colorectal cancer patients. In the second, plasma carcinoembryonic antigen was compared with serum k isozyme of lactate dehydrogenase as an indicator of the presence of metastatic cancer. This comparison showed that both markers were independently useful for assessing patient status and predicted that a combination of the two should be a better discriminator for the presence of metastases than either marker alone.
authors: Department of Molecular, Roswell Park Memorial Institute, Buffalo, New York 14263.
authors: K F
authors: KF
authors: Manly
authors: N
authors: N
authors: Petrelli
authors: G R
authors: GR
authors: Anderson
authors: L J
authors: LJ
authors: Emrich
authors: L
authors: L
authors: Herrera
authors: A
authors: A
authors: Mittelman
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D003110:Colonic Neoplasms / Q000097:blood / Q000473:pathology*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D009362:Neoplasm Metastasis; D012004:Rectal Neoplasms / Q000097:blood / Q000473:pathology*; D012016:Reference Values
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase