title: Cross-tolerance between morphine and ethanol and their antinociceptive effects.
abstract: Morphinization of mice (37.5 mg morphine) and rats (75 mg) with subcutaneously implanted pellets has resulted in tolerance to the antinociceptive effect of morphine, measured in the tail-immersion test. All animals also developed cross-tolerance to the analgesic effects of ethanol (2.8 g/kg intraperitoneally for mice, per os for rats). These results suggest a commonality between morphine and ethanol antinociceptive action.
authors: Department of Pharmacodynamics, Medical Academỳ, Lublin, Poland.
authors: D
authors: D
authors: Malec
authors: J
authors: J
authors: Kotlińska
authors: R
authors: R
authors: Langwiński
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000503:physiopathology; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects
chemical_list: D000700:Analgesics; D000431:Ethanol; D009020:Morphine