Preliminary investigations into the involvement of the intestinal microflora in CNS toxicity induced by 1,3-dinitrobenzene in male F-344 rats.
Administration of a single oral dose of 20 mg/kg of 1,3-dinitrobenzene caused ataxia in germ-free male F-344 rats but not in conventional rats. Repeated oral dosing of 20 mg/kg, 1,3-DNB was required to cause ataxia in conventional rats. Considerable differences were observed between the uptake, tissue distribution and excretion of DNB in germ-free and conventional rats.
Philbert
M A
MA
Toxicology Unit, Medical Research Council Laboratories, Carshalton, Surrey, U.K.
Gray
A J
AJ
Connors
T A
TA
D000284:Administration, Oral; D000818:Animals; D001259:Ataxia / Q000139:chemically induced* / Q000382:microbiology / Q000473:pathology; D001419:Bacteria / Q000302:isolation & purification* / Q000378:metabolism; D001711:Biotransformation; D001921:Brain / Q000187:drug effects / Q000473:pathology; D004136:Dinitrobenzenes / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D005856:Germ-Free Life; D007422:Intestines / Q000382:microbiology*; D008297:Male; D008706:Methemoglobin / Q000032:analysis; D009578:Nitrobenzenes / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344
D004136:Dinitrobenzenes; D009578:Nitrobenzenes; D008706:Methemoglobin; C017906:3-dinitrobenzene