Monocyte esterase? A factor involved in the pathogenesis of lymphoproliferative neoplasia.
Monocyte esterase activity was studied in 1,000 doctor-attending patients with normal hematological indices and in 56 patients with non-Hodgkin's lymphoma (NHL) or B chronic lymphocytic leukemia (CLL). The incidence of esterase deficiency was significantly greater in the NHL-CLL patients (7.1%) than in the population group (1.7%; p less than 0.05). In the NHL-CLL group, study of the families showed the esterase deficiency to be a familial characteristic. We postulate that the presence of the anomaly may be either a factor predisposing to the development of the NHL or CLL or a factor indicating a predisposition to these disorders.
Markey
G M
GM
Haematology Department, Belfast City Hospital, Northern Ireland.
Morris
T C
TC
Alexander
H D
HD
Kyle
A
A
Middleton
D
D
Turner
A
A
Burnside
P
P
Drexler
H G
HG
Gaedicke
G
G
Hartmen
W
W
D004950:Esterases / Q000097:blood*; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D007945:Leukemia, Lymphoid / Q000201:enzymology / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology / Q000235:genetics; D008232:Lymphoproliferative Disorders / Q000201:enzymology* / Q000235:genetics; D009000:Monocytes / Q000201:enzymology*; D010375:Pedigree
D007527:Isoenzymes; D004950:Esterases