title: Lung carcinogenesis by N-nitrosobis(2-hydroxypropyl)amine-related compounds and their formation in rats.
abstract: Lung carcinogenesis by a single intraperitoneal injection of N-nitrosobis(2-hydroxypropyl)amine (NDHPA) and related compounds was studied in male Wistar rats. NDHPA, N-nitrosomethyl(2-hydroxypropyl)amine (NMHPA), N-nitrosobis(2-oxopropyl)amine (NDOPA), N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (NHPOPA) and N-nitroso-2,6-dimethylmorpholine (NDMMOR) induced high incidences of lung neoplasms in rats. The formation of NDHPA, NDMMOR and NMHPA in the stomach of rats treated with precursor amines and sodium nitrite was detected by high-performance liquid chromatography (HPLC).
authors: Department of Oncological Pathology, Nara Medical College, Japan.
authors: Y
authors: Y
authors: Konishi
authors: Y
authors: Y
authors: Yokose
authors: Y
authors: Y
authors: Mori
authors: H
authors: H
authors: Yamazaki
authors: K
authors: K
authors: Yamamoto
authors: A
authors: A
authors: Nakajima
authors: A
authors: A
authors: Denda
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D009602:Nitrosamines; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009602:Nitrosamines; C012457:diisopropanolnitrosamine