title: Synthesis of 7a-substituted benzoylaminoalkyl-hexahydro-1H-pyrrolizines and evaluation of their antiarrhythmic activity.
abstract: Several 7a-substituted benzoylaminoalkyl-hexahydro-1 H-pyrrolizines were synthesized by acylations of 7a-aminoalkyl-hexahydro-1 H-pyrrolizines. All compounds synthesized were evaluated for their antiarrhythmic activities using the chloroform-mouse method, and some of them were found to have significant antiarrhythmic activities, comparable to that of procainamide.
authors: Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
authors: S
authors: S
authors: Miyano
authors: K
authors: K
authors: Shima
authors: M
authors: M
authors: Hayashimatsu
authors: F
authors: F
authors: Satoh
authors: K
authors: K
authors: Sumoto
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D001549:Benzamides / Q000138:chemical synthesis / Q000627:therapeutic use / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D002725:Chloroform; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011342:Procainamide / Q000627:therapeutic use; D011758:Pyrroles / Q000138:chemical synthesis / Q000627:therapeutic use* / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D001549:Benzamides; D011758:Pyrroles; D002725:Chloroform; D011342:Procainamide