[The additive index--a new preclinical indicator of the addictive potential of analgesic agents].
A comparative study of analgesic and secondary-reinforcing properties of morphine, nalorphine, pentazocine and phencyclidine was carried out on mice. Different rations of their analgesic and reinforcement potencies were revealed. Based on these results, a new indicator--"addictive index" is proposed for characterization of the addictive potential of analgesics.
Evartau
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EE
Kovalenko
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VS
D000700:Analgesics; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D008722:Methods; D051379:Mice; D009020:Morphine; D009269:Nalorphine; D010423:Pentazocine; D010622:Phencyclidine; D011379:Prognosis; D019966:Substance-Related Disorders / Q000209:etiology*; D013997:Time Factors
D000700:Analgesics; D009020:Morphine; D010622:Phencyclidine; D010423:Pentazocine; D009269:Nalorphine
Additivnyĭ indeks--novyĭ doklinicheskiĭ pokazatel' toksikomanicheskogo potentsiala boleutoliaiushchikh sredstv.