Chronic granulomatous disease in an adult.
We have described a 49-year-old man with chronic granulomatous disease. The diagnosis was established by a deficiency of NBT dye reduction by neutrophils, in addition to impairment in 14C-1-glucose utilization, 125I-iodination of zymosan, chemiluminescence, superoxide radical generation, and bactericidal activity toward S aureus. This adult patient exhibits many characteristics of chronic granulomatous disease of childhood but of less severity, which may explain his unusually long survival. It is thus important to consider the diagnosis of chronic granulomatous disease not only in children but also in adult patients having the characteristic pattern of recurrent infections.
Nerurkar
L S
LS
Department of Pediatrics, Georgetown University Medical Center, Washington, DC 20007.
Jacob
A
A
Zeligs
B
B
Walser
J
J
Yeager
H
H
Bellanti
J A
JA
D001770:Blood Bactericidal Activity; D002448:Cell Adhesion; D002634:Chemotaxis, Leukocyte; D006105:Granulomatous Disease, Chronic / Q000097:blood / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008163:Luminescent Measurements; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology; D010587:Phagocytosis
D007136:Immunoglobulins