A genetic linkage map of the human genome.
We report the construction of a linkage map of the human genome, based on the pattern of inheritance of 403 polymorphic loci, including 393 RFLPs, in a panel of DNAs from 21 three-generation families. By a combination of mathematical linkage analysis and physical localization of selected clones, it was possible to arrange these loci into linkage groups representing 23 human chromosomes. We estimate that the linkage map is detectably linked to at least 95% of the DNA in the human genome.
Donis-Keller
H
H
Department of Human Genetics, Collaborative Research, Inc., Bedford, Massachusetts 01730.
Green
P
P
Helms
C
C
Cartinhour
S
S
Weiffenbach
B
B
Stephens
K
K
Keith
T P
TP
Bowden
D W
DW
Smith
D R
DR
Lander
E S
ES
D002874:Chromosome Mapping; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D010375:Pedigree; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D012727:Sex Characteristics