Efficacy of levamisole and netobimin against Haemonchus contortus in lambs in Louisiana.
Efficacy of levamisole was evaluated in a suspected levamisole-resistant population of Haemonchus contortus in the Louisiana State University sheep flock. The efficacy of netobimin also was evaluated against this population of Haemonchus. In trial 1, 5 lambs naturally infected with H contortus were given 8 mg of levamisole/kg of body weight as a drench, and 5 lambs were not treated (controls). Nematode recovery after slaughter indicated 0% efficacy against H contortus. In trial 2, 30 nematode-free lambs were each given 8,300 F1 generation infective larvae of H contortus, which were derived from parent H contortus that survived 2 levamisole treatments in lambs being maintained in a nematode-free environment. Ten lambs were treated with 8 mg of levamisole/kg as a drench, 10 were treated with 20 mg of netobimin/kg as a drench, and 10 were not treated (control). Nematode recovery after slaughter revealed 62.3% and 99.8% efficacy for levamisole and netobimin, respectively, against H contortus.
Miller
J E
JE
Department of Epidemiology and Community Health, Louisiana Agricultural Experiment Station, Louisiana State University, Baton Rouge.
Hembry
F G
FG
Kearney
M T
MT
Williams
J C
JC
Stagg
L C
LC
Sims
D
D
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D004341:Drug Evaluation / Q000662:veterinary; D006146:Guanidines / Q000627:therapeutic use*; D006188:Haemonchiasis / Q000188:drug therapy / Q000662:veterinary*; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D007978:Levamisole / Q000627:therapeutic use*; D008145:Louisiana; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy / Q000469:parasitology*; D014252:Trichostrongyloidiasis / Q000662:veterinary*
D000871:Anthelmintics; D006146:Guanidines; D007978:Levamisole; C049626:netobimin