Effects of oestrogen and human growth hormone on pregnancy-associated plasma proteins in the rat.
The serum concentrations of pregnancy-associated murine protein-1 (PAMP-1), acute phase alpha 2-macroglobulin, albumin, transferrin, and complement factor 3(C3) were followed in male rats during continuous infusions of oestradiol-17 beta and human growth hormone. Three different patterns of protein response could be distinguished. A distinct acute phase response without any additive influence of the given hormones was recorded for alpha 2-macroglobulin, whereas the levels of albumin, transferrin and C3 were virtually unaffected throughout the experiment. Growth hormone gave a rapid and pronounced increase of PAMP-1 levels, whereas the response to oestradiol of this 'steroid-sensitive' protein was significantly weaker and delayed. It is suggested that the apparent oestrogenic influence on certain pregnancy-associated plasma proteins is mediated via growth hormone.
Carlsson-Bostedt
L
L
Department of Physiological Chemistry, University of Umea, Sweden.
Fröhlander
N
N
Edén
S
S
Stigbrand
T
T
von Schoultz
B
B
D000818:Animals; D003176:Complement C3 / Q000032:analysis; D004958:Estradiol / Q000494:pharmacology*; D013006:Growth Hormone / Q000494:pharmacology*; D007118:Immunoassay; D008297:Male; D011257:Pregnancy Proteins / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000032:analysis; D014168:Transferrin / Q000032:analysis
D003176:Complement C3; D011257:Pregnancy Proteins; D012709:Serum Albumin; D014168:Transferrin; C033484:pregnancy-associated murine protein 1; D004958:Estradiol; D013006:Growth Hormone