title: Some long term effects of smoking on the haemostatic system: a report from the Caerphilly and Speedwell Collaborative Surveys.
abstract: Data from two community studies on men from South Wales and the west of England suggest that the effects of smoking on the haemostatic system remain for many years after giving up. Long term correlations between several variables, including plasma fibrinogen and white cell count, and the length of time after giving up were seen in ex-smokers. Dose response relations were apparent in current smokers in terms of the white cell count and two haematological variables, the packed and mean cell volumes. These long term correlations probably reflect the toxicity of other agents in tobacco smoke besides nicotine and carbon monoxide, which act only in the short term. Identification of these agents may further our understanding of the mechanism by which cigarette smoking is associated with atherosclerotic disease.
authors: MRC Epidemiology Unit (South Wales), Cardiff.
authors: J W
authors: JW
authors: Yarnell
authors: P M
authors: PM
authors: Sweetnam
authors: S
authors: S
authors: Rogers
authors: P C
authors: PC
authors: Elwood
authors: D
authors: D
authors: Bainton
authors: I A
authors: IA
authors: Baker
authors: R
authors: R
authors: Eastham
authors: J R
authors: JR
authors: O'Brien
authors: M D
authors: MD
authors: Etherington
mesh_terms: D001809:Blood Viscosity; D004912:Erythrocytes / Q000166:cytology; D005340:Fibrinogen / Q000032:analysis; D006400:Hematocrit; D006487:Hemostasis; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000097:blood*; D013918:Thrombin Time; D013997:Time Factors
chemical_list: D005340:Fibrinogen