title: [Isolation of chlorphenoxamine metabolites in human urine and their identification].
abstract: After the administration of chlorphenoxamine (2-[1-(4-chlorophenyl)-1-phenylethoxy]-N,N-dimethylethanamine++ +, Systral) (I) the following compounds have been detected in human urine. They were identified as chlorphenoxamine (I), N-demethyl-chlorphenoxamine (II), chlorphenoxamine-N-oxide (III), 1-(4-chlorophenyl)-l-phenylethanol (IV), 1-(4-chlorophenyl)-1-(4'-hydroxyphenyl)-ethanol (V), 1-(4-chlorophenyl)-1-(4'-hydroxyphenyl)-ethene (VI), 1-(4-chlorophenyl)-1-(4'-hydroxy-3'-methoxyphenyl)-ethanol (VII), 1-(4-chlorophenyl)-1-(4'-hydroxy-3'-methoxyphenyl)-ethene (VIII), 2-[1-(4-chlorophenyl)-1-(4'-hydroxyphenyl)-ethoxy]-N-methyl-ethanamine (IX) and 2-[1-(4-chlorophenyl)-1-(4'-hydroxy-3'-methoxyphenyl-ethoxy]- N-methylethanamine (X). The compounds IV, V, VI, VII, VIII, IX and X were also found to be excreted as conjugates. It cannot be excluded that the compounds VI and VIII are artefacts.
authors: Institut für Rechtsmedizin, Universität Bonn.
authors: S
authors: S
authors: Goenechea
authors: G
authors: G
authors: Rücker
authors: H
authors: H
authors: Brzezinka
authors: G
authors: G
authors: Hoffmann
authors: M
authors: M
authors: Neugebauer
authors: T
authors: T
authors: Pyzik
mesh_terms: D000328:Adult; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D005021:Ethylamines / Q000652:urine*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D005021:Ethylamines; C100100:chlorphenoxamine
vernacular_title: Isolierung von Chlorphenoxamin-Metaboliten aus menschlichem Harn und ihre Identifizierung.