Injection of noradrenaline into the hypothalamic paraventricular nucleus produces vigorous gnawing in satiated rats.
Single injections of noradrenaline (NA) into the hypothalamic paraventricular nucleus (PVN) initiate short bouts of eating in the rat. The effect of the injections of NA (40 nM) into the PVN on gnawing was studied in satiated male rats that had displayed a reliable eating response to NA. The NA injections produced numerous bouts of prolonged and vigorous gnawing of wood pieces shaped like food pellets. The gnawing response started 0.5-2 min after the injection of NA and lasted for 20-25 min. The results suggest that the increase in gnawing and eating evoked by NA might be related to facilitation of the oral responses, and a changed sensitivity to the food related stimuli, in addition to an intrinsic increase in appetite.
Swiergiel
A H
AH
Institut de Pharmacologie de l'Université de Lausanne, Switzerland.
Peters
G
G
D000818:Animals; D005215:Fasting; D005247:Feeding Behavior / Q000187:drug effects; D008297:Male; D008409:Mastication / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000502:physiology
D009638:Norepinephrine