Effect of sex hormones on lipid peroxidation in the necrotic liver of rat.
Influence of sex-hormones on hepato-toxicosis induced by 2 halogenalkanes viz. carbon tetrachloride and trichloroethylene has been studied in rats. Rate of peroxidative decomposition thus measured by determining malonaldehyde has shown the protective effects of testosterone on CCl4 toxicity but an additive effect on injury caused by trichloroethylene, whereas progesterone failed to offer protection against their toxicity. Modification in histopathological lesions thus caused by these hormones have also been studied and discussed.
Rana
S V
SV
School of Environmental Contamination and Toxicology, Department of Zoology, D.A.V. College, Muzaffarnagar, India.
Kumar
S
S
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D005260:Female; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009336:Necrosis; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*; D014241:Trichloroethylene / Q000633:toxicity
D008054:Lipid Peroxides; D014241:Trichloroethylene; D013739:Testosterone; D011374:Progesterone; D008315:Malondialdehyde