[Effect of physical exertion on the status of the heart and central hemodynamics as affected by external (60Co) and internal (239PuO2) irradiation].
Experiments were conducted on mongrel dogs aged 2 to 4 with the body mass of 15.1 +/- 0.9 kg. The animals were exposed to combined and isolated gamma-irradiation at a dose of 51.6 mC/kg and submicron 239PuO2 in the amount not less than 7 kBq/kg. Single circular irradiation was provided from 60Co gamma-sources at a dose rate of 1.03-1.3 mA/kg. 239PuO2 was inhaled 6 days after irradiation. 20 min. running on a treadmill with the speed of 4.7 km/h served as a physical exercise model. The dogs were examined 0.5, 1, 1.5 and 4 yrs. after the initiation of the experiment at rest and within 1 h after physical exercise. Methods of tetrapolar chest rheography and electrocardiography were employed. It was shown that in the combined effect of two radiation factors the rates of increase in the cardiac index were inhibited at the expense of physical exercise influence as compared to those in the isolated radionuclide effect and resulted from less "economical" heart action.
Karpova
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D000818:Animals; D003037:Cobalt Radioisotopes; D004285:Dogs; D005260:Female; D006321:Heart / Q000528:radiation effects*; D006439:Hemodynamics / Q000528:radiation effects*; D008297:Male; D005082:Physical Exertion; D011005:Plutonium
D003037:Cobalt Radioisotopes; C026885:plutonium dioxide; D011005:Plutonium
Vliianie fizicheskoĭ nagruzki na sostoianie serdtsa i tsentral'noĭ gemodinamiki u sobak pri vozdeĭstvii vneshnego (60Co) i vnutrennogo (239PuO2) oblucheniia.