[45Ca2+ and 3H-GABA transport in nerve endings separated from the cerebral cortex of rats with hypoparathyroidism].
Ca2+ blood serum level was reduced by 34.5% in rats with hypoparathyroidism (HPT) on the 7th-12th day after the damage of parathyroid glands. Synaptosomes isolated from the brain cortex of rats during this period accumulated in a normal medium more 45Ca2+ than synaptosomes from healthy animals. In potassium depolarization, control and experimental synaptosomes accumulated more 45Ca2+, however in HPT the increment in 45Ca2+ uptake in high potassium medium was less temperature-dependent. In normal medium 3H-GABA uptake and release by synaptosomes from the brain of rats with HPT slightly differed from those in the control. On the contrary, 3H-GABA release induced by synaptosome depolarization was depressed in HPT. It is suggested that nerve terminal excretory function disturbances contribute to increased excitability of the central nervous system in hypoparathyroidism.
Ter-Markosian
A S
AS
Lutsenko
V K
VK
Khudaverdian
D N
DN
Khlebnikova
N N
NN
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D002540:Cerebral Cortex / Q000378:metabolism*; D007011:Hypoparathyroidism / Q000378:metabolism*; D008297:Male; D009411:Nerve Endings / Q000378:metabolism*; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism; D013997:Time Factors; D014316:Tritium; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D002132:Calcium Radioisotopes; D014316:Tritium; D005680:gamma-Aminobutyric Acid; D002118:Calcium
Transport 45Ca2+ i 3H-GAMK v nervnykh okonchaniiakh, vydelennykh iz kory golovnogo mozga krys s gipoparatireozom.