An osmium-191/iridium-191m radionuclide generator using an oxalato osmate parent complex.
A new osmium-191/iridium-191m (191Os/191mIr) radionuclide generator has been developed that offers high 191mIr yield (greater than 20%/ml) and low 191Os breakthrough (less than 5 X 10(-4)%/ml) when eluted with a solution of 0.001 M oxalic acid and 0.9% (normal) saline. This is the first 191Os/191mIr generator that combines the advantages of high 191mIr yield, extremely low 191Os breakthrough, and an eluate that does not require buffering prior to injection. These improvements in performance were accomplished through use of the chelate transdioxobisoxalatoosmate(VI) as the parent complex on the generator. The clinical result of the combination of higher yield and lower breakthrough is a 100-fold decrease in the estimated patient radiation dose compared with the same study performed with technetium-99m (99mTc), and the injectable eluate makes the generator easier to use. Acute and subacute toxicity studies performed on this generator eluate have shown no adverse effects attributable to the eluate.
Packard
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Division of Nuclear Medicine, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Treves
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O'Brien
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Lim
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KS
D007495:Iridium; D007554:Isotopes; D009942:Organometallic Compounds; D009992:Osmium; D010070:Oxalates; D011868:Radioisotopes; D011876:Radionuclide Generators
D007554:Isotopes; D009942:Organometallic Compounds; D010070:Oxalates; D011868:Radioisotopes; C053832:dioxobis(oxalatoosmalate) (IV); D009992:Osmium; D007495:Iridium