Elevation of serum aluminum in humans on a two-day sucralfate regimen.
Serum aluminum concentrations were determined in ten healthy subjects treated with phenytoin 500 mg and with sucralfate and phenytoin in a crossover fashion. Each subject received four 1,000-mg sucralfate tablets between 8 AM and 10 PM one day before the study, and this was repeated during the study day. A total of eight doses of sucralfate was administered over the two-day period. Serum samples were drawn at 0, 2, 4, 8, 12, 24, 32, and 48 hours after administration. The areas under the serum aluminum concentration-time curves before and after sucralfate (mean +/- SD) were 496.0 +/- 80.9 and 770.9 +/- 146.6 hr-ng/mL, respectively. This increase is statistically significant (P less than .01), indicating that serum aluminum levels are elevated even after two days of treatment with sucralfate. The results from this study are not in agreement with the only other report on this subject.
Pai
S
S
School of Pharmacy, University of Missouri, Kansas City 64108-2792.
Melethil
S
S
Cuddy
P
P
Hall
T
T
D000328:Adult; D000535:Aluminum / Q000097:blood*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000494:pharmacology; D013392:Sucralfate / Q000009:adverse effects* / Q000493:pharmacokinetics
D013392:Sucralfate; D010672:Phenytoin; D000535:Aluminum