Oral ethanol reinforcement in the rat: effect of the partial inverse benzodiazepine agonist RO15-4513.
The partial inverse benzodiazepine agonist RO15-4513 has been found to reverse the sedating and anti-conflict effects of acute ethanol administration. In non-food or fluid-deprived rats, orally self-administering 10% ethanol in an operant situation, RO15-4513 resulted in a dose-dependent suppression on ethanol intake. Doses of 0.3, 1.0 and 3.0 mg/kg suppressed responding from approximately 25% to 60% respectively. A dose of 0.1 mg/kg had no significant effect upon responding. These findings were discussed in terms of the potential independence of brain mechanisms related to ethanol reinforcement and sedation.
Samson
H H
HH
Alcoholism and Drug Abuse Institute, University of Washington, Seattle 98105.
Tolliver
G A
GA
Pfeffer
A O
AO
Sadeghi
K G
KG
Mills
F G
FG
D000284:Administration, Oral; D000818:Animals; D001386:Azides / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D012054:Reinforcement, Psychology; D012646:Self Administration
D001386:Azides; D001569:Benzodiazepines; D000431:Ethanol; C042957:Ro 15-4513