title: A myopathy associated with muscle hypertonicity in the Cavalier King Charles Spaniel.
abstract: Clinical signs of electrically silent muscle hypertonicity are described in five Cavalier King Charles dogs. Biopsies of the biceps femoris and triceps muscles, when examined with the electron microscope, revealed evidence of sarcotubular and mitochondrial abnormalities. These included enlargement of the sarcoplasmic reticulum, hydropic degeneration of mitochondria, tubular proliferations in the vicinity of the triads and vacuolar invagination of mitochondria. The exact nature of these findings is not clear and it is suggested that utilization of tracer techniques would help to explain them.
authors: Royal Veterinary College Field Station, Hatfield, Herts, U.K.
authors: J A
authors: JA
authors: Wright
authors: J B
authors: JB
authors: Smyth
authors: S E
authors: SE
authors: Brownlie
authors: M
authors: M
authors: Robins
mesh_terms: D000818:Animals; D001706:Biopsy; D004283:Dog Diseases / Q000473:pathology* / Q000503:physiopathology; D004285:Dogs; D009132:Muscles / Q000473:pathology* / Q000648:ultrastructure; D009135:Muscular Diseases / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*