Pharmacokinetics of a single dose of rimantadine in young adults and children.
Single doses of rimantadine were given to children and young adults to evaluate the safety and pharmacokinetics of this antiviral compound. The half-life of rimantadine in young adults was 27.7 +/- 4.9 h for tablets and 27.8 +/- 8.0 h for syrup preparations. A total of 10 children, 5 to 8 years old, received a syrup preparation of rimantadine. The half-life of rimantadine in children was 24.8 +/- 9.4 h. A single dose of rimantadine was well tolerated in young adults and children.
Anderson
E L
EL
Department of Medicine, Marshall University School of Medicine, Huntington, West Virginia 25701.
Van Voris
L P
LP
Bartram
J
J
Hoffman
H E
HE
Belshe
R B
RB
D000218:Adamantane / Q000031:analogs & derivatives*; D000284:Administration, Oral; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D011897:Random Allocation; D012299:Rimantadine / Q000008:administration & dosage / Q000378:metabolism*; D012996:Solutions; D013607:Tablets
D012996:Solutions; D013607:Tablets; D012299:Rimantadine; D000218:Adamantane