[Erosive gastritis: an aggravating cause of anemia in patients treated for chronic renal insufficiency].
Anemia is one of the commonest and most serious complications of chronic renal failure. The causes are multiple, while gastrointestinal blood loss is often unrecognized. Eleven hemodialyzed patients underwent esogastroduodenoscopy (OGD) to investigate anemia requiring transfusion of 4 or more blood units in a 6-month period. The same investigator performed all the endoscopies using the following scores: 0 = no lesions, 1 = focal red appearance of the mucosa, 2 = bleeding of the mucosa due to the gastroscope, 3 = erosive lesions, and 4 = presence of ulcers. Patients with a score of 1 or more were treated with ranitidine in a dose of 150-300 mg daily for 6 months. The need for transfusions before and after OGD was compared. The results were as follows: 8 of 11 patients had a score of 1-3, 1 patient scored 4 and 2 patients had no lesions. After 6 months' treatment with ranitidine no differences in hematocrit values were noted but the need for transfusions was significantly reduced (8.6 +/- 1.4 blood units before OGD vs. 4.9 +/- 1.3 blood units in the 6 months following OGD). It is concluded that minimal lesions of the esogastroduodenal mucosa are very common in hemodialyzed patients and ranitidine treatment could reduce the need for blood transfusions in these patients.
Robert
D
D
Service d'hémodialyse, Hôpital de la Providence, Neuchâtel.
Voirol
M
M
Guelpa
G
G
Pfister
E
E
D000740:Anemia / Q000209:etiology*; D005260:Female; D005756:Gastritis / Q000150:complications*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
La gastrite érosive: cause aggravante d'anémie chez les patients traités pour insuffisance rénale chronique.