Mean residence time in peripheral tissue.
The published methods for determining the mean residence time for drugs in peripheral tissue are reviewed in terms of assumptions involved, advantages and disadvantages. A method for determining mean transit time in peripheral tissue is proposed; this may be a more useful indicator of the tissue retention properties for drug compounds.
McNamara
P J
PJ
Division of Pharmaceutics and Pharmaceutical Analysis, College of Pharmacy, University of Kentucky, Lexington 40536.
Fleishaker
J C
JC
Hayden
T L
TL
D006207:Half-Life; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D014018:Tissue Distribution