Effect of bilirubin and bile acids on biliary phospholipid secretion during bromobenzene-induced hepatic injury in the rabbit.
The interrelationship between the biliary secretion of phospholipids, bilirubin and bile acids was studied in New Zealand rabbits after acinar zone 3 hepatocyte damage induced by bromobenzene (4 mmol/kg body wt; i.p.). Treatment with the toxin did not significantly modify biliary phospholipid secretion, suggesting that the transport of phospholipids is mainly a zone 1 function. Bilirubin infusion at 1 mumol/min kg body wt induced a significant inhibition in biliary phospholipid secretion both in control and treated animals. This effect was overcome by the additional infusion of sodium glycodeoxycholate at 1.6 mumol/min kg body wt, although higher increases in phospholipid output were found in the control than in the treated rabbits. This would be related to the lowered recruitment of zone 3 cells for secretion in bromobenzene-damaged livers.
González
J
J
Department of Physiology and Pharmacology, Faculty of Pharmacy, University of Salamanca, Spain.
Muñoz
M E
ME
Esteller
A
A
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism* / Q000494:pharmacology; D001969:Bromobenzenes / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury; D006002:Glycodeoxycholic Acid / Q000494:pharmacology; D008107:Liver Diseases / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D011817:Rabbits
D001647:Bile Acids and Salts; D001969:Bromobenzenes; D010743:Phospholipids; D006002:Glycodeoxycholic Acid; C032036:bromobenzene; D001663:Bilirubin