[In vitro effects of 3 immunosuppressive drugs. Comparison of the effect of cyclosporin A, methylprednisolone and 6-mercaptopurine].
Several tests of cellular immunity representing in vitro correlates of early lymphocytes activation have been studied with 3 immunosuppressive drugs currently used in organ transplantation, 6-mercaptopurine, cyclosporin A and methylprednisolone. Despite its significant antiproliferative action, 6-mercaptopurine does not affect interleukin 2 production nor Ia antigen induction on lymphocytes after stimulation with phytohemagglutinin. In contrast, cyclosporin A and methylprednisolone strongly block this reaction. Both immuno-suppressive drugs disclose equivalent blocking action on all proliferative reactions with the exception of proliferation induced by phorbol myristate acetate which is resistant to cyclosporin A but inhibited by methylprednisolone.
Dupont
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Service d'Immunologie, Hôpital Erasme, Cliniques Universitaires de Bruxelles, Université Libre de Bruxelles, Belgique.
D000911:Antibodies, Monoclonal / Q000494:pharmacology; D003524:Cyclosporins / Q000494:pharmacology*; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation / Q000187:drug effects*; D015122:Mercaptopurine / Q000494:pharmacology*; D008775:Methylprednisolone / Q000494:pharmacology*
D000911:Antibodies, Monoclonal; D003524:Cyclosporins; D015122:Mercaptopurine; D008775:Methylprednisolone
Effets in vitro de 3 drogues immunosuppressives. Comparaisons de l'action de la cyclosporine A, de la méthylprednisolone et de la 6-mercaptopurine.