Role of sensory renal nerves in the development of spontaneous hypertension in rats.
In order to study the role of afferent renal nerves in the development of spontaneous hypertension, 3-4 weeks old uninephrectomized spontaneously hypertensive rats were deafferented selectively by a unilateral dorsal rhizotomy. Control rats were sham-operated. Until 10 weeks of age, systolic tail cuff blood pressures were identical in both groups. Although from 12 weeks on systolic blood pressure was slightly (10%) but significantly lower in deafferented rats, mean arterial pressures from an indwelling catheter were identical in deafferented and control rats. We therefore conclude that a selective destruction of afferent renal nerves does not delay or prevent the development of spontaneous hypertension in rats.
Janssen
B J
BJ
Dept. of Pharmacology, University of Limburg, Maastricht, The Netherlands.
Debets
J J
JJ
Struyker-Boudier
H A
HA
Smits
J F
JF
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology; D003714:Denervation; D005260:Female; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D007262:Infusions, Intravenous; D007267:Injections; D007668:Kidney / Q000294:innervation*; D051381:Rats; D011918:Rats, Inbred SHR; D012677:Sensation / Q000502:physiology*
D001920:Bradykinin