title: Metaiodobenzylguanidine to map scintigraphically the adrenergic nervous system in man.
abstract: Metaiodobenzylguanidine (MIBG) localizes in adrenergic neurons; MIBG labeled with 123I then serves as an analog of norepinephrine, and concentrations of [123I]MIBG reflect sites of adrenergic neurons in organs. Movements of [123I]MIBG into and out of organs were measured by quantitative scintigraphy in man. We perturbed adrenergic neuron function in several ways, and [123I]MIBG concentrations in the heart were subsequently altered in patterns consistent with the concept that [123I]MIBG resides mostly in adrenergic neurons. Uptake of [123I]MIBG into the heart was inhibited by the tricyclic drug, imipramine, and this agent also accelerated the rate of loss of [123I]MIBG. Phenylpropanolamine, a sympathomimetic drug that acts by displacing norepinephrine from neurons, increased the rates of loss of [123I]MIBG from the heart. Exercise was followed by a movement of [123I]MIBG into blood and urine. Generalized autonomic neuropathies were associated with marked diminutions of [123I]MIBG uptake into the heart. We conclude that quantitative scintigraphy in patients will enable determinations of regional disturbances in integrity (by measuring uptake of [123I]MIBG) and function (by measuring rates of loss of [123I]MIBG) of the adrenergic nervous system in the heart.
authors: Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0028.
authors: J C
authors: JC
authors: Sisson
authors: B
authors: B
authors: Shapiro
authors: L
authors: L
authors: Meyers
authors: S
authors: S
authors: Mallette
authors: T J
authors: TJ
authors: Mangner
authors: D M
authors: DM
authors: Wieland
authors: J V
authors: JV
authors: Glowniak
authors: P
authors: P
authors: Sherman
authors: W H
authors: WH
authors: Beierwaltes
mesh_terms: D019797:3-Iodobenzylguanidine; D000320:Adrenergic Fibers / Q000000981:diagnostic imaging* / Q000187:drug effects; D000328:Adult; D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000000981:diagnostic imaging; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000294:innervation*; D006801:Humans; D007099:Imipramine / Q000494:pharmacology; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D010665:Phenylpropanolamine / Q000494:pharmacology; D005082:Physical Exertion; D011877:Radionuclide Imaging
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D010665:Phenylpropanolamine; D019797:3-Iodobenzylguanidine; D007099:Imipramine