Renal findings in rheumatoid arthritis: clinical aspects of 132 necropsies.
Renal abnormalities in 132 necropsied patients with rheumatoid arthritis were studied. Clinical findings before death included extra-articular manifestations of the disease (86% of patients), systemic vasculitis (6%), and uraemia (23%). Necropsy findings included nephrosclerosis (90%), systemic vasculitis (14%) with kidney involvement in 8%, amyloidosis (11%), membranous glomerulopathy (8%), and focal glomerular disease (8%). Association with clinical data suggests that both rheumatoid and non-rheumatoid disease may play a part in the cause of these abnormalities.
Boers
M
M
Department of Rheumatology, Leiden University, The Netherlands.
Croonen
A M
AM
Dijkmans
B A
BA
Breedveld
F C
FC
Eulderink
F
F
Cats
A
A
Weening
J J
JJ
D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000209:etiology / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000209:etiology / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014657:Vasculitis / Q000209:etiology / Q000473:pathology