Suxamethonium in myasthenia gravis.
The effects of suxamethonium 1.0 and 0.5 mg/kg were studied in myasthenic patients. Resistance was not encountered at the 1.0 mg/kg dose but was seen at the lower dose. A non-depolarising type of block developed in patients in both groups. However, recovery from the non-depolarising block was not prolonged beyond the requirements of surgery. The neurophysiological basis for, and clinical implications of these findings are discussed.
Wainwright
A P
AP
National Hospital for Nervous Diseases, Queen Square, London.
Brodrick
P M
PM
D000293:Adolescent; D000328:Adult; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000503:physiopathology*; D009469:Neuromuscular Junction / Q000187:drug effects*; D013390:Succinylcholine / Q000494:pharmacology*; D013997:Time Factors
D013390:Succinylcholine