title: Mannosidosis: ocular lesions in the bovine model.
abstract: The ocular pathology of mannosidosis was studied in the bovine model. There was wide-spread vacuolation of many cell types including corneal epithelium, Descemet's endothelium, corneal fibroblasts, pigmented cells, lens epithelium, lens fibres, pigment epithelium and all cell types of the neuroretina. On electron-microscopy most vacuoles were seen to be membrane bound vesicles compatible with being secondary lysosomes and similar to those previously described elsewhere in the body. Additional vacuoles were seen due to dilatations between lens epithelial cells and between lens fibres. The cause of lens and corneal opacities seen in human patients is unclear from the present study but are presumably a consequence of the lesions noted.
authors: Department of Veterinary Pathology and Public Health, Massey University, Palmerston North, New Zealand.
authors: R D
authors: RD
authors: Jolly
authors: A
authors: A
authors: Shimada
authors: R R
authors: RR
authors: Dalefield
authors: P M
authors: PM
authors: Slack
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D003315:Cornea / Q000473:pathology; D004195:Disease Models, Animal; D005123:Eye / Q000473:pathology*; D007498:Iris / Q000473:pathology; D007908:Lens, Crystalline / Q000473:pathology; D008854:Microscopy, Electron; D009887:Ophthalmoscopy; D009900:Optic Nerve / Q000473:pathology; D012160:Retina / Q000473:pathology; D012590:Sclera / Q000473:pathology; D008363:alpha-Mannosidosis / Q000473:pathology / Q000662:veterinary*