[Effect of intracisternal administration of antisera against neurospecific enolase (protein 14-3-2) on avoidance behavior in rats].
The antisera to three isoenzymes (alpha alpha, alpha gamma, and gamma gamma) of the rat neurospecific enolase were studied. gamma gamma-antiserum administered into the brain cistern (8 microliters) prior to learning, in contrast to two other antisera, impaired the retrieval of passive avoidance response within 1-28 days after learning. Maximal amnestic effect occurred in the first 3 days. Probable mechanisms of the neurospecific enolase participation in the formation of memory traces, are discussed.
Shabanov
P D
PD
Usatenko
M S
MS
D000818:Animals; D001362:Avoidance Learning; D001921:Brain / Q000201:enzymology*; D007106:Immune Sera / Q000008:administration & dosage*; D007527:Isoenzymes / Q000276:immunology / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000276:immunology* / Q000502:physiology; D010751:Phosphopyruvate Hydratase / Q000276:immunology* / Q000502:physiology; D051381:Rats
D007106:Immune Sera; D007527:Isoenzymes; D009419:Nerve Tissue Proteins; D010751:Phosphopyruvate Hydratase
Vliianie vnutritsisternal'nogo vvedeniia antisyvorotok k neĭrospetsificheskoĭ enolaze (belku 14-3-2) na povedenie izbeganiia krys.