Hemorrheological, micro- and macrocirculatory effects of naftidrofuryl in an acute study: a randomized, placebo-controlled, double-blind individual comparison.
In an intraindividual comparison, the effects of a single dose of 600 mg naftidrofuryl on the fluidity of blood, the conjunctival and transcutaneous partial pressure of oxygen and blood flow through the micro- and macrocirculation were compared with placebo, given in random order to a group of 10 women, apparently healthy apart from showing hemorrheological abnormalities. There were significant increases in erythrocyte deformability, conjunctival partial pressure of oxygen, mean blood flow in the common carotid and femoral arteries. All increases were significant compared to both the initial values and the data in the placebo group. The maximal effect was observed after 1.5 h (capillary erythrocyte velocity, blood flow in the common carotid artery) or 3 h (conjunctival partial pressure of oxygen, blood flow in the femoral artery). After 4.5 h all effects had disappeared.
Jung
F
F
Department of Clinical Haemostasiology and Transfusion Medicine, University of the Saarland, Homburg/Saar, FRG.
Kiesewetter
H
H
Mrowietz
C
C
Leipnitz
G
G
Braun
B
B
Wappler
M
M
Scheffler
P
P
Wenzel
E
E
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects*; D004311:Double-Blind Method; D004907:Erythrocyte Deformability / Q000187:drug effects; D005260:Female; D005663:Furans / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008833:Microcirculation / Q000187:drug effects*; D009257:Nafronyl / Q000627:therapeutic use*; D010101:Oxygen Consumption / Q000187:drug effects; D011674:Pulse / Q000187:drug effects; D011897:Random Allocation
D005663:Furans; D009257:Nafronyl