Abnormal heart rate tracings and serum creatine phosphokinase in addicted neonates.
Continuous cardiorespirographic (CRG) monitoring was done during the first five postnatal days in 12 infants of drug dependent mothers (IDDM) and 19 normal infants (control). Abnormal heart rate patterns in the IDDM included: (1) significantly (p less than 0.01) higher baseline heart rate (129 +/- 15 vs. 118 +/- 8), beat-to-beat variability (4.4 +/- 2.4 vs. 2.6 +/- 1.6) and long-term variability (15.5 +/- 6.6 vs. 7.0 +/- 3.9), as compared to control and (2) frequent and spontaneous occurrences of large (40 beats per minute), brief rise and fall in heart rate giving a striking "wave-like" appearance to the tracing. These changes were more intense in the IDDM with moderate to severe, as compared to mild withdrawal. Treatment of the infant's withdrawal with drugs resulted in a clinical improvement, but the abnormal heart rate tracings persisted. Serum creatine phosphokinase (CPK) was also elevated (greater than 450 IU/l) in the IDDM (mean +/- SE = 984 +/- 299 IU/l) and 89% of the total CPK was the MM fraction. These infants exhibited tremors and hypertonicity.
Ostrea
E M
EM
Department of Pediatrics, Hutzel Hospital, Detroit, MI.
Kresbach
P
P
Knapp
D K
DK
Simkowski
K
K
D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D007527:Isoenzymes; D008691:Methadone / Q000009:adverse effects; D009357:Neonatal Abstinence Syndrome / Q000097:blood / Q000503:physiopathology*; D011247:Pregnancy; D012119:Respiration / Q000187:drug effects
D007527:Isoenzymes; D003402:Creatine Kinase; D008691:Methadone