Augmentation of postresection mucosal hyperplasia by plerocercoid growth factor (PGF). Analog of human growth hormone.
Postresection villus hyperplasia is a major compensatory mechanism in the short-bowel patient. Substances capable of augmenting postresection mucosal hyperplasia could have therapeutic implications. Human growth hormone (hGH) and human growth hormone releasing factor (hGHRF) stimulate growth of the gastrointestinal tract; however, the diabetogenic actions of growth hormone limit its usefulness in clinical practice. Plerocercoid larvae of the tapeworm Spirometra mansonoides produce an analog of hGH void of diabetogenic side effects. We assessed effects of plerocercoid growth factor (PGF) on mucosal adaptation following 70% proximal jejunoileal resection in young rats. Mucosal weight, DNA, protein, and total sucrase activity per centimeter of bowel were increased in resected PGF-treated animals compared to resected controls. We conclude PGF augments intrinsic postresection mucosal hyperplasia following extensive intestinal resection.
Hart
M H
MH
Department of Pediatrics, University of Nebraska Medical Center, Omaha.
Phares
C K
CK
Erdman
S H
SH
Grandjean
C J
CJ
Park
J H
JH
Vanderhoof
J A
JA
D000818:Animals; D004247:DNA / Q000032:analysis; D004353:Drug Evaluation, Preclinical; D005260:Female; D013006:Growth Hormone / Q000031:analogs & derivatives*; D006133:Growth Substances / Q000494:pharmacology*; D006965:Hyperplasia; D007082:Ileum / Q000187:drug effects / Q000601:surgery; D036341:Intercellular Signaling Peptides and Proteins; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology* / Q000502:physiology; D007583:Jejunum / Q000187:drug effects / Q000601:surgery; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013393:Sucrase / Q000378:metabolism
D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; C043871:plerocercoid growth factor; D013006:Growth Hormone; D004247:DNA; D013393:Sucrase