title: Alterations in DNA methylation in human colon neoplasia.
abstract: A review of studies on DNA methylation in colonic neoplasia is presented. Hypomethylation of a wide variety of genes from throughout the genome was seen in all colon cancers studied. These changes preceded malignancy because benign adenomas were also affected.
authors: Howard Hughes Medical Institute, Ann Arbor, MI.
authors: A P
authors: AP
authors: Feinberg
authors: B
authors: B
authors: Vogelstein
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism; D003110:Colonic Neoplasms / Q000378:metabolism*; D003111:Colonic Polyps / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism*; D006801:Humans; D008745:Methylation
chemical_list: D004273:DNA, Neoplasm