title: A quantitative investigation into the effects of pupil diameter and defocus on contrast sensitivity for an extended range of spatial frequencies in natural and homatropinized eyes.
abstract: Contrast sensitivity was measured in 12 subjects for different spatial frequencies of sinusoidal grating patterns, generated by oscilloscope, for pupil diameters 2-8 mm and for defocus of +1-4 D, following homatropine eyedrops. Changes in pupil diameter, without correction for the change in retinal illumination, had no significant effect on contrast sensitivity, except at 0.5 and 1 c deg-1 when a significant reduction occurred with the 2 mm pupil. Defocus caused a large reduction in contrast sensitivity at spatial frequencies higher than the peak of the contrast sensitivity function (3 c deg-1) and a smaller reduction below the peak. In both individual and group results, there was no significant effect of defocus in causing a disproportionately greater reduction in contrast sensitivity at higher spatial frequencies nor were the zero mimina predicted by optical theory observed. The results were confirmed in eight subjects viewing with the natural eye, though the reduction in contrast sensitivity caused by +1 D defocus was not significant: this was attributed to the relaxation of accommodation in response to defocus. To predict the performance of the visual system, multiple regression equations were derived to incorporate terms for pupil diameter, defocus and spatial frequency. These equations reflected the lack of effect of pupil diameter, while defocus caused a 51% loss in contrast sensitivity per dioptre at higher spatial frequencies (3-38 c deg-1) and a 19% reduction at low spatial frequencies.
authors: Institute of Physiology, University of Glasgow, U.K.
authors: C D
authors: CD
authors: Kay
authors: J D
authors: JD
authors: Morrison
mesh_terms: D000065:Accommodation, Ocular; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D011680:Pupil / Q000187:drug effects; D013028:Space Perception / Q000187:drug effects / Q000502:physiology*; D014326:Tropanes / Q000494:pharmacology
chemical_list: D014326:Tropanes; C100236:homatropine