[The number and ultrastructure of large granule-containing lymphocytes (natural killer cells) in the blood of patients with diabetes mellitus type 1].
The content and ultrastructure of blood large granule containing lymphocytes (LGL) associated with the system of natural killer cells (NKC) were investigated in primary untreated patients with type I diabetes mellitus using light and electron microscopy. A marked decrease in the content of LGL and change in their submicroscopic structure indicating disorder of their function, were noted in the blood of patients with type I diabetes mellitus as compared to those in the blood of healthy subjects. LGL cytoplasm revealed a decrease in the number and size of specific electron dense granules (azurophil granules), their destruction and vacuolization were noted; the number of peculiar submicroscopic formations (parallel tubular structures) was on an increase. A conclusion has been made that in type I diabetes mellitus the activity of the system of natural killer cells playing an important role in nonspecific protection of the body is lowered and therefore can be regarded as a cause of more frequent development of inflammatory processes in this disease.
Zak
K P
KP
Khomenko
B M
BM
Afanas'eva
V V
VV
Sakalo
E A
EA
D000293:Adolescent; D000328:Adult; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000648:ultrastructure; D007958:Leukocyte Count; D008297:Male
Soderzhanie i ul'trastruktura bol'shikh granulosoderzhashchikh limfotsitov (estestvennykh kletok-killerov) v krovi bol'nykh sakharnym diabetom I tipa.