title: Gastrocystoplasty and colocystoplasty in canines: the metabolic consequences of acute saline and acid loading.
abstract: An experimental canine model was developed to quantitate the net transmural ion flux of colon and gastric segments used for augmentation cystoplasty. Gastrocystoplasty (4) or colocystoplasty (4) was constructed in 8 female mongrels. Acute intravenous saline and acid loading experiments were performed 2 to 4 weeks after cystoplasty. The mean solute excretion rates for sodium, chloride, phosphorus and ammonia exhibited opposite trends during acute saline and acid loading in this experimental model. The net flux of chloride, ammonia, phosphorus and sodium ions in the colocystoplasty animals was from the mucosa/urine surface to the serum (reabsorption). The opposite trend was true for the gastrocystoplasty. By not reabsorbing ammonium chloride, the gastrocystoplasty preserved an important renal mechanism for systemic acid elimination. This may help to prevent the hyperchloremic metabolic acidosis that can develop when urine comes in contact with small or large bowel segments.
authors: James Whitcomb Riley Hospital for Children, Indiana University Medical Center, Indianapolis.
authors: J A
authors: JA
authors: Piser
authors: M E
authors: ME
authors: Mitchell
authors: T B
authors: TB
authors: Kulb
authors: R C
authors: RC
authors: Rink
authors: H A
authors: HA
authors: Kennedy
authors: A
authors: A
authors: McNulty
mesh_terms: D000136:Acid-Base Equilibrium; D000643:Ammonium Chloride / Q000378:metabolism; D000818:Animals; D003106:Colon / Q000378:metabolism / Q000637:transplantation*; D004285:Dogs; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D011184:Postoperative Period; D012965:Sodium Chloride / Q000378:metabolism; D013270:Stomach / Q000637:transplantation*; D001743:Urinary Bladder / Q000378:metabolism / Q000601:surgery*; D014882:Water-Electrolyte Balance
chemical_list: D000643:Ammonium Chloride; D012965:Sodium Chloride