Failure to detect dopamine receptor IgG autoantibodies in sera of schizophrenic patients. Short note.
Autoantibodies against dopamine receptors in schizophrenic patients have been postulated. IgG was fractionated from sera of 15 schizophrenic patients (DSM III) in an acute episode. However, 3H-spiperone binding to dopamine receptors was not inhibited by this fraction.
von Kirchbach
A
A
Neurologische Universitätsklinik, Ulm, Federal Republic of Germany.
Fischer
E G
EG
Kornhuber
H H
HH
D001323:Autoantibodies / Q000032:analysis*; D001667:Binding, Competitive; D006220:Haloperidol / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D011954:Receptors, Dopamine / Q000276:immunology* / Q000378:metabolism; D012559:Schizophrenia / Q000276:immunology*; D013134:Spiperone / Q000378:metabolism
D001323:Autoantibodies; D007074:Immunoglobulin G; D011954:Receptors, Dopamine; D013134:Spiperone; D006220:Haloperidol