Follicular fluid concentrations of thiopental and thiamylal during laparoscopy for oocyte retrieval.
Because access into ovarian tissue of drugs used during anesthesia may be potentially harmful to the oocyte and/or follicular structure, we measured concentrations of thiopental (n = 15) and thiamylal (n = 9) in follicular fluid (FF) aspirates of 24 patients who underwent laparoscopic oocyte retrieval. In both groups, measurable amounts of the respective drug were found in all FF aspirates. Within individual patients, plasma concentrations of both drugs declined during the period of sampling between initial and final follicular aspiration. The mean plasma drug concentration was 7.99 +/- 3.97 micrograms/ml in the thiamylal group and 4.13 +/- 0.90 micrograms/ml in the thiopental group. Mean drug concentrations in FF were similar in both groups (thiopental 1.62 +/- 0.61 micrograms/ml; thiamylal 1.67 +/- 0.83 micrograms/ml). The mean FF/plasma concentration ratio during the sampling period was greater in the thiopental group (0.41 +/- 0.19) as compared with the thiamylal group (0.22 +/- 0.14). Several steps in the clinical management of these patients can be taken to reduce exposure of oocytes to drugs used during anesthesia.
Endler
G C
GC
Department of Anesthesiology, Wayne State University, Hutzel Hospital, Detroit, Michigan 48201.
Stout
M
M
Magyar
D M
DM
Hayes
M F
MF
Moghissi
K S
KS
Sacco
A G
AG
D000328:Adult; D001826:Body Fluids / Q000378:metabolism*; D005260:Female; D006801:Humans; D009865:Oocytes / Q000187:drug effects; D006080:Ovarian Follicle / Q000378:metabolism*; D013840:Thiamylal / Q000097:blood / Q000493:pharmacokinetics*; D013874:Thiopental / Q000097:blood / Q000493:pharmacokinetics*
D013840:Thiamylal; D013874:Thiopental