title: Derivatives of 1,2,3,3-tetramethyl-2-azabicyclo [2.2.2]-octan-5-trans-ol with antiarrhythmic and other activities. VII.
abstract: The synthesis of a series of alkyl and aryl ureas (II) starting from 5-trans-(3-aminoproxy)-1,2,3,3-tetramethyl-2-azabicyclo [2.2.2]-octane is described. Some compounds (II) showed appreciable antiarrhythmic activity in rats and infiltration anesthesia in mice, as well as weak hypotensive and bradycardic activities in rats.
authors: Istituto di Scienze Farmaceutiche, Università di Genova, Italy.
authors: M
authors: M
authors: Longobardi
authors: A
authors: A
authors: Bargagna
authors: P
authors: P
authors: Schenone
authors: D
authors: D
authors: De Santis
authors: M
authors: M
authors: Angrisani
authors: E
authors: E
authors: Marmo
mesh_terms: D000779:Anesthetics, Local / Q000138:chemical synthesis; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D006339:Heart Rate / Q000187:drug effects; D051379:Mice; D051381:Rats; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D014508:Urea