title: Significance of the fluid-blood interface in intracranial hematomas in anticoagulated patients.
abstract: Six patients receiving anticoagulant medication who had laboratory evidence of impaired hemostasis as manifested by laboratory parameters exceeding the therapeutic range developed intracranial hemorrhages. None of these patients had a history of preceding trauma. None of the 6 anticoagulated had CNS symptoms prior to initiation of anticoagulant medication. Within the intracranial hemorrhage there was a fluid-blood interface in these 6 patients; this finding was seen only in hemorrhages in anticoagulated patients. In 3 cases the fluid-blood interface changed to a homogeneous hyperdense lesion when adequate hemostasis was achieved. In one case there were multiple hemorrhages and in the other there was a solitary intracerebral hemorrhage.
authors: Department of Neurology and Psychiatry, Tulane Medical School, New Orleans, LA 70112.
authors: L A
authors: LA
authors: Weisberg
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D001780:Blood Coagulation Tests; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D005260:Female; D006408:Hematoma, Subdural / Q000139:chemically induced; D006487:Hemostasis / Q000187:drug effects; D006493:Heparin / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D013300:Streptokinase / Q000009:adverse effects; D013924:Thrombophlebitis / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
chemical_list: D000925:Anticoagulants; D006493:Heparin; D013300:Streptokinase