[Antioxidant-induced release of calcium in biological membranes].
The effect of synthetic (BHT, 2,2,5,7,8-pentamethyl-6-hydroxychroman) and natural (alpha-tocopherol) antioxidants on Ca++-transporting systems was compared in platelets, brain synaptosomes, and skeletal muscle sarcoplasmic reticulum. It was shown that synthetic antioxidants, in contrast to alpha-tocopherol, induced Ca++-release manifested in platelet aggregation, stimulation of 5-hydroxytryptamine release by synaptosomes, synaptosome depolarization and inhibition of Ca++-transport and Ca++-ATPase activity in the sarcoplasmic reticulum. The disturbances of Ca++-homeostasis induced by synthetic antioxidants are considered as molecular mechanisms of complications encountered upon their application.
Muranov
K O
KO
Buldygerova
N V
NV
Kovaleva
E S
ES
Erin
A N
AN
Prilipko
L L
LL
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D002839:Chromans / Q000494:pharmacology; D007425:Intracellular Membranes / Q000187:drug effects*; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000187:drug effects; D013574:Synaptosomes / Q000187:drug effects; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D002839:Chromans; D014810:Vitamin E; D002084:Butylated Hydroxytoluene; C029141:2,2,5,7,8-pentamethyl-1-hydroxychroman; D002118:Calcium
Indutsiruemye antioksidantami utechki kal'tsiia v biologicheskikh membranakh.