Effects of age on apparent 31P spin-lattice relaxation times of rat brain phosphates.
Apparent 31P spin-lattice relaxation times have been measured in vivo for brain phosphates in young adult, mature adult, and aged rats at 4.7 T and 35 degrees C. Statistically significant differences were found for most phosphate species, except PCr and gamma-ATP, among the three age groups, particularly between the young and mature adults. Age-related changes in tissue composition and exchange reactions are discussed as possible contributors to these results.
Stolk
J A
JA
Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112.
Olsen
J I
JI
Alderman
D W
DW
Schweizer
M P
MP
D000255:Adenosine Triphosphate / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010710:Phosphates / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344
D010710:Phosphates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate