The prophylactic effect of doxycycline on postoperative infection rate after first-trimester abortion.
A prospective double-blind study was performed to evaluate the effect of prophylactic antibiotic treatment before induced abortion. Eight hundred consecutive women admitted for first-trimester abortion, without signs of genital infection or antibiotic use in the last three weeks, were included in the study. Doxycycline 400 mg or placebo was given as a single oral dose ten to 12 hours before vacuum aspiration. Ninety-one women (11.8%) returned to the hospital with suspected complications. Thirty-two of these women were diagnosed as having pelvic inflammatory disease, eight of whom (2.1%) had received doxycycline before the abortion and 24 of whom (6.2%) had received placebo, a statistically significant difference (P less than .01). A history of pelvic inflammatory disease increased the risk of developing it again after an abortion.
Darj
E
E
Department of Obstetrics and Gynecology, Falun Hospital, Sweden.
Strålin
E B
EB
Nilsson
S
S
D000367:Age Factors; D004311:Double-Blind Method; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007434:Intrauterine Devices; D000292:Pelvic Inflammatory Disease / Q000209:etiology / Q000517:prevention & control*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D011897:Random Allocation
D004318:Doxycycline