[Morphofunctional state of the gastric parietal and gastrin-producing cells in chronic gastroduodenitis in children].
Morphofunctional studies of parietal and gastrin-producing cells in 30 children with chronic gastroduodenitis with (10 patients) or without (20) recurrent erosions in the pyloroduodenal region showed functional inhibition of G cells and hyperplasia of P cells in the antral part of the stomach in children with recurring erosions. In these children, the increased surface area and density of parietal cells, the increased perimeters of secretory canaliculi's membranes, and the consequent elevated gastric juice acidity were probably due to P-cell hyperplasia in the gastric antrum and G-cell hyperplasia in the duodenal bulb. In children, gastroduodenitis with recurrent erosions should be considered a pathogenetic variant of duodenal ulcerous disease.
Chumakov
A M
AM
Kuznetsov
S V
SV
Daurova
N V
NV
D000293:Adolescent; D001706:Biopsy; D002648:Child; D002908:Chronic Disease; D004382:Duodenitis / Q000473:pathology*; D004386:Duodenum / Q000648:ultrastructure; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism / Q000648:ultrastructure; D005755:Gastrins / Q000378:metabolism*; D005756:Gastritis / Q000473:pathology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D010295:Parietal Cells, Gastric / Q000648:ultrastructure*; D012008:Recurrence
D005755:Gastrins
Morfofunktsional'noe sostoianie parietal'nykh i gastrinprodutsiruiushchikh kletok zheludka pri khronicheskom gastroduodenite u deteĭ.