The three-dimensional structure of trichosanthin molecule.
A model completed recently of two trichosanthin molecules in an asymmetric unit belonging to the monoclinic system is reported. It can be seen that the molecular structure consists of two domains, one large and one small, and that there are some features in the secondary structure. The dissimilarity between two molecules as well as their interactions in an independent unit correlated in a non-symmetric way has been described, moreover, the binding sites of the heavyatom position in the derivatives are also discussed.
Pan
K Z
KZ
Fujian Institute of Research on the Structure of Matter, Academia Sinica, Fuzhou.
Lin
Y J
YJ
Fu
Z J
ZJ
Zhou
K J
KJ
Cai
Z P
ZP
Chen
Z W
ZW
Zhang
Y M
YM
Dong
Y C
YC
Wu
S
S
Ma
X Q
XQ
D000019:Abortifacient Agents / Q000032:analysis*; D000020:Abortifacient Agents, Nonsteroidal / Q000032:analysis*; D008958:Models, Molecular; D010940:Plant Proteins / Q000032:analysis*; D015978:Trichosanthin
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D010940:Plant Proteins; D015978:Trichosanthin