[Effect of naloxone on hypoalgesia in rats exposed to prolonged immobilization stress].
Significant hypoalgesia (tail-flick reflex at 60 degrees C) was observed in rats during the whole period of 24-hour immobilization in cramped cages, as compared to food-and-water deprived and control animals. This hypoalgesia was not antagonized by naloxone (1 mg/kg), however, the animals periodically receiving the drug during immobilization revealed aggressiveness and significant hypoalgesia after immobilization was discontinued (30-120 min observation).
Kiiatkin
E A
EA
Shamakina
I Iu
IIu
Zhukov
V N
VN
D000818:Animals; D007103:Immobilization; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
D009270:Naloxone
Vliianie naloksona na gipoalgeziiu u krys v usloviiakh dlitel'nogo immobilizatsionnogo stressa.