Effects of growth, degeneration and regeneration on the sensory motor system.
Evidence was presented for regeneration and growth in the central nervous system of experimental animals and in the peripheral nervous system of man. Neurophysiological, neurohistological and neurochemical findings from the cerebellothalamocortical and the nigrostriatal projection systems as well as the motoneurons of the anterior horn and facial nucleus were presented and their possible functional implications discussed. Single unit recordings from regenerated primary afferents in human peripheral nerves were also shown and discussed in the light of their clinical relevance. The conclusions were reached that the findings of positive growth in the CNS following traumatic injury or in response to brain implants left little doubt that the CNS possesses the intrinsic capability of regeneration. The functional and clinical implications of this inherent capacity awaits further research. Recording the response behavior of regenerated primary afferents in man, on the other hand, provided more direct insight into functional deficits and their clinical correlates.
Mackel
R
R
Rockefeller University, New York, N.Y.
D000818:Animals; D001369:Axons / Q000502:physiology; D001927:Brain Diseases / Q000628:therapy; D002531:Cerebellum / Q000502:physiology; D004298:Dopamine / Q000378:metabolism; D004568:Electrodiagnosis; D006801:Humans; D009046:Motor Neurons / Q000502:physiology; D009068:Movement; D009410:Nerve Degeneration; D009416:Nerve Regeneration; D009420:Nervous System / Q000254:growth & development*; D009422:Nervous System Diseases / Q000175:diagnosis; D009424:Nervous System Physiological Phenomena; D009474:Neurons / Q000378:metabolism / Q000637:transplantation; D010525:Peripheral Nerves / Q000502:physiology; D012677:Sensation
D004298:Dopamine