title: Synthesis and antitumor activity of triazolium-bis(triazole)-tetrachlororuthenate (III) and bistriazolium-triazolepentachlororuthenate (III). Two representatives of a new class of inorganic antitumor agents.
abstract: The synthesis of the two water-soluble heterocycle coordinated ruthenium complexes triazolium-bis(triazole) tetrachlororuthenate (III), TrH(RuTr2Cl4), and bistriazolium-triazolepentachlororuthenate (III), (TrH)2(RuTrCl5), is described. For these complexes, antitumor activity against the P 388 leukemia model was observed with T/C values of 137% to 150%, compared with 144% and 175% for 5-fluorouracil and cisplatin, respectively. These complexes belong to a new class of antitumor active ruthenium compounds with the general formulas HB(RuB2Cl4) and (HB) 2(RuBCl5). The here described complexes with B = triazole are less active than the same type of complexes with B = imidazole, which were described by us previously.
authors: Anorganisch-Chemisches Institut, Universität Heidelberg, Fed. Rep. of Germany.
authors: B K
authors: BK
authors: Keppler
authors: W
authors: W
authors: Balzer
authors: V
authors: V
authors: Seifried
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D014230:Triazoles; C054036:triazolium-bis(triazole)tetrachlororuthenate(III); C054035:bistriazolium-triazolepentachlororuthenate(III)