title: Effect of ascorbic acid on the metabolism of N-nitrosopiperidine.
abstract: Guinea-pigs were fed diets containing 48, 200 or 2000 mg/kg ascorbic acid (AsA) for 20-30 days and given a single oral dose of 50 mg N-nitrosopiperidine (NPIP)/kg body weight. The levels of glutaric acid, 3-hydroxy-NPIP and 4-hydroxy-NPIP, but not of 1,5-pentanediol, in urine increased with the dose of AsA in the diet.
authors: Kanagawa Prefectural Public Health Laboratory, Yokohama, Japan.
authors: M
authors: M
authors: Nakamura
authors: Y
authors: Y
authors: Osada
authors: Y
authors: Y
authors: Horiguchi
authors: T
authors: T
authors: Nakaoka
authors: K
authors: K
authors: Ito
authors: T
authors: T
authors: Kawabata
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D004032:Diet; D006168:Guinea Pigs; D009602:Nitrosamines / Q000378:metabolism* / Q000652:urine
chemical_list: D009602:Nitrosamines; C002743:N-nitrosopiperidine; D001205:Ascorbic Acid