title: Day and night aspirin-induced gastric mucosal damage and protection by ranitidine in man.
abstract: The severity of gastric mucosal injury produced by aspirin (ASA) was endoscopically assessed during morning and evening studies in 10 healthy, male volunteers. In a randomized, double-blind design, subjects received either ASA (1300 mg) alone or ASA (1300 mg) plus Ranitidine (150 mg) or placebo tablets during morning and evening studies. Each subject had 3 morning and 3 evening studies. The severity of damage produced by ASA was assessed by counting the number of punctate mucosal hemorrhages observed in the gastric antrum and low-body. This study demonstrated (1) wide intersubject variability in the severity of damage produced by ASA (range of 47-1030 lesions/subject in morning studies), (2) significant protection against ASA-induced damage by Ranitidine and (3) significantly greater damage produced by ASA in the morning compared to the evening studies. Because evening acid secretory rates are higher and because ASA-induced damage is believed to be acid-dependent, this last observation was unexpected. It suggests mucosal resistance is higher in the evening and raises the possibility that there may be circadian variation in gastric mucosal resistance.
authors: Section of Gastroenterology, Salt Lake City VAMC, Utah 84148.
authors: J G
authors: JG
authors: Moore
authors: R H
authors: RH
authors: Goo
mesh_terms: D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D002940:Circadian Rhythm; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D008297:Male; D011899:Ranitidine / Q000494:pharmacology
chemical_list: D011899:Ranitidine; D001241:Aspirin