Secretory state and acute gastric mucosal injury in sepsis.
Cats were subjected to a standardized 3-h septicemia by intravenous infusion of live Escherichia coli in an LD50 dose. The effect of pentagastrin stimulation on the development of gastric mucosal injury was studied. There was no hemodynamic difference between the series during septicemia. Thus, pentagastrin did not induce increased gastric blood flow during the period of E. coli infusion. Intraluminal gastric pH was lower in the series given pentagastrin during the last 2 h of septicemia. Nevertheless, the extent of gastric mucosal injury was similar in the two groups, whereas the depth of injury was, if anything, less pronounced in the pentagastrin-stimulated group.
Arvidsson
S
S
Dept. of Surgery, Malmö General Hospital, University of Lund, Sweden.
Fält
K
K
Haglund
U
U
D000208:Acute Disease; D000818:Animals; D002415:Cats; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D006439:Hemodynamics; D010418:Pentagastrin / Q000494:pharmacology*; D018805:Sepsis / Q000150:complications / Q000503:physiopathology*; D013276:Stomach Ulcer / Q000209:etiology*
D010418:Pentagastrin