Effect of copper sulphate on the rate of afferent discharge in the gastric branch of the vagus nerve in the rat.
The afferent nerve activity was recorded from a nerve filament isolated from the peripheral cut end of the gastric branch of the vagus nerve. The gastric perfusion of 4 ml of two different concentrations (0.04% and 0.08%) of CuSO4 solution provoked an increase in afferent activity. The stimulating effect of the 0.08% solution was stronger than that of the 0.04% solution, and lasted for a longer period of time. The observations suggest a possible mechanism by which CuSO4 elicits emesis.
Niijima
A
A
Department of Physiology, Niigata University School of Medicine, Japan.
Jiang
Z Y
ZY
Daunton
N G
NG
Fox
R A
RA
D000818:Animals; D003300:Copper / Q000494:pharmacology*; D019327:Copper Sulfate; D004594:Electrophysiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology
D003300:Copper; D019327:Copper Sulfate