title: Mean residence time in peripheral tissue.
abstract: The published methods for determining the mean residence time for drugs in peripheral tissue are reviewed in terms of assumptions involved, advantages and disadvantages. A method for determining mean transit time in peripheral tissue is proposed; this may be a more useful indicator of the tissue retention properties for drug compounds.
authors: Division of Pharmaceutics and Pharmaceutical Analysis, College of Pharmacy, University of Kentucky, Lexington 40536.
authors: P J
authors: PJ
authors: McNamara
authors: J C
authors: JC
authors: Fleishaker
authors: T L
authors: TL
authors: Hayden
mesh_terms: D006207:Half-Life; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D014018:Tissue Distribution