Antilung cancer activities of selenium.
Selenium is considered an essential trace element in most animal and plant species, although still reported in many texts as a highly toxic material. Epidemiological investigations have reported an inverse relationship between selenium and lung cancer. Explanations of reported observations have resulted in numerous mechanistic theories. Only recently have selenium metabolites involved in excretion been considered potential agents for antilung cancer activity. Anticancer properties have been shown in occupationally exposed copper smelter workers, dietary investigations and experimental studies. Supplementation with selenium of public water supplies, as is currently done with fluoride, is a potential method for increasing the blood concentration. This may permit development of a population prevention strategy against lung cancer and other diseases.
Lange
J H
JH
Graduate School of Public Health, University of Pittsburgh, PA 15261.
Talbott
E O
EO
Baffone
K M
KM
Weyel
D A
DA
Soboslay
E G
EG
Koros
A M
AM
Sykora
J L
JL
D006801:Humans; D008175:Lung Neoplasms / Q000517:prevention & control*; D012643:Selenium / Q000008:administration & dosage / Q000502:physiology*; D014481:United States; D014881:Water Supply
D012643:Selenium