[Problems of the relationship of the therapeutic effect and the concentration of drugs in the blood].
Certain approaches to analysis of the drug concentration-response relationship based on the mechanism of the effect realization and the results of their clinical trials are discussed. The studies are exemplified by a model for quantitative analysis of the concentration-response relationship developed for diuretics and by the results of the clinical trial of the principle of the maximum providing prediction of the steady-state level of the drugs in blood and estimation of the drug effect.
Glezer
M G
MG
Iakovlev
S V
SV
Kholodov
L E
LE
D000368:Aged; D004077:Digoxin / Q000097:blood / Q000627:therapeutic use*; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005665:Furosemide / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008433:Mathematics; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy; D013997:Time Factors
D004077:Digoxin; D005665:Furosemide
Problemy sviazi terapevticheskogo éffekta i kontsentratsii lekarstvennykh veshchestv v krovi.