Therapeutic effects of sofalcone on experimental gastritis.
A study was made on the therapeutic effects of sofalcone (SU-88), an antiulcer agent, on erosive and atrophic gastritis induced experimentally by 6-month administration of 5 mmol/l of sodium taurocholate (TCA) in rats. A standard meal including sofalcone of 0.25% and 1.0% shortened the total length of erosions, normalized the mucosal thickness, and reduced collagenous fibers in the gastric mucosa in one month. The doses administered were 116.3 mg and 486.1 mg/kg/week for one month. Sofalcone, thus, had a good therapeutic effect on experimental erosive and atrophic gastritis in rats.
Kishimoto
S
S
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Okamoto
K
K
Kambara
A
A
Kajiyama
G
G
Miyoshi
A
A
Suwa
T
T
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002599:Chalcone / Q000031:analogs & derivatives / Q000627:therapeutic use*; D047188:Chalcones; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D011427:Propiophenones / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D000897:Anti-Ulcer Agents; D047188:Chalcones; D011427:Propiophenones; C035032:sofalcone; D002599:Chalcone