[Serum thiopental values, spontaneous frontal muscle electromyography activity and compressed EEG amplitudes and frequency values in thiopental infusion anesthesia].
Serum thiopentone (S-Thiop) was estimated every 10 minutes using a new high performance liquid chromatographic method during fentanyl-bolus-complemented (0.01 mg) thiopentone infusion anaesthesia (bolus of 5 mg/kg, infusion dosis 23.7 mg/min) for laryngo-microscopic procedures. Before stopping the infusion after 18/17 min (SD 8/5) (male/female) S-Thiop was (mean (SD) range) 16.0/12.4 (4.6/5.7) 5.9-26.8/5.1-26.6 mg/l; after stop of the infusion 12.8/10.5 (4.5/5.3) 7.6-25.5/4.5-23.4 mg/l. Patients reacted to verbal command after 11.5 (10.3) 11-81 min. There were no clinically relevant correlations between S-Thiop and frontal EMG and compressed 1-channel-EEG (ABM, Datex, Helsinki), nor with data recorded during recovery. Reasons may be: the total depolarisation block caused by succinylcholine; the method of compressing the EEG; subjective influences on the recording of recovery data; sampling in intervals of 10 min instead of at certain points of the anaesthesia course. We still recommend this total i.v.-anaesthesia for the short time endolaryngeal procedures need; before using this method for longer periods additional pharmacokinetic studies should be performed.
Baer
G A
GA
Abteilung für Anästhesiologie, Universitätszentralkrankenhaus Tampere, Finnland.
Harmoinen
A
A
Parviainen
M
M
Rorarius
M
M
Eerola
R
R
D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D001143:Arousal / Q000187:drug effects; D004569:Electroencephalography; D004576:Electromyography; D005071:Evoked Potentials / Q000187:drug effects; D005152:Facial Muscles / Q000187:drug effects; D005260:Female; D006801:Humans; D007818:Laryngeal Diseases / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D013874:Thiopental / Q000097:blood
D013874:Thiopental
Serum-Thiopentalwerte, spontane M.-frontalis-EMG-Aktivität und komprimierte EEG-Amplituden- und Frequenzwerte bei Thiopentalinfusions-anästhesie.