The influence of ketanserin, droperidol and hydergine on postoperative hypertension during early recovery following major abdominal surgery.
Forty adult patients, who developed postoperative hypertension (greater than 160/90 mm Hg) following major abdominal surgery were given double-blind, randomized either ketanserin 10 mg i.v. (n = 10), droperidol 5 mg i.v. (n = 10), hydergine 0.9 mg i.v. (n = 10) or placebo solution (n = 10). Following the injection of ketanserin or droperidol systolic and diastolic blood pressure decreased significantly (p less than 0.001 and p less than 0.01), but were no longer significantly lowered 30 minutes following the injection in 5 out of 10 ketanserin treated and in 8 out of ten droperidol treated patients. Neither hydergine nor placebo had a significant effect on blood pressure. It is concluded, that both ketanserin and droperidol have a moderate and short acting antihypertensive effect.
Anger
C
C
Klinik für Anästhesiologie und operative Intensivmedizin der Westfälischen Wilhelms-Universität, Münster, Fed. Rep. of Germany.
Van Aken
H
H
Hoch
D
D
Lawin
P
P
D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004088:Dihydroergotoxine / Q000627:therapeutic use; D004311:Double-Blind Method; D004329:Droperidol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007650:Ketanserin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*; D011897:Random Allocation
D000959:Antihypertensive Agents; D004088:Dihydroergotoxine; D007650:Ketanserin; D004329:Droperidol