title: Spontaneous wheel running in laboratory rats genetically selected for activity level in a novel environment.
abstract: Wistar rats were genetically selected for either high (+A) or low (-A) locomotor activity level in a new environment. The response to the novelty was tested in all filial generations at the age between 75-80 days of life. Groups of 15 +A male rats selected from the 11th and 12th generations were placed in the individual cages connected with rotation wheels at the age 149 +/- 9 days. For a period of 32 days, the spontaneous wheel running activity was recorded for the time intervals 0.00-6.00 a.m., 6.00-12.00, 12.00-18.00, and 18.00-24.00 h. The -A group exhibited a generally low level of running activity over the entire experimental period, whereas the time of running in the +A tended to increase. Inside the +A group, homogeneous as to the short- term activity level, there gradually differentiated two sub-groups, one with relatively constant medium values and the other which showed an enormous prolongation of the time spent with running. The +A and -A groups differed also in their daily activity rhythm. Whereas the +A rats reached maximum of their activity between 18-24 h., followed by a rapid decrease in the morning hours, the -A animals showed a tendency to a later onset of night-type activity, and a higher level continued to morning hours.
authors: Laboratory of Evolutionary Biology, Czechoslovak Academy of Sciences, Praha.
authors: S
authors: S
authors: Franková
authors: J
authors: J
authors: Parízková
authors: A
authors: A
authors: Mikulecká
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D004777:Environment; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D051381:Rats / Q000235:genetics; D011919:Rats, Inbred Strains; D012641:Selection, Genetic