Assessment of neutrophil function in dogs with primary ciliary dyskinesia.
Compared with neutrophils from healthy dogs, neutrophils from 2 dogs with primary ciliary dyskinesia had increased distance of random migration, but fewer of the neutrophils migrated. The affected dogs had an increase in the numbers of Staphylococcus aureus phagocytized. Lymphocyte blastogenesis in the affected dogs in response to standard mitogens was considered to be normal.
Morrison
W B
WB
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames 50011.
Frank
D E
DE
Roth
J A
JA
Wilsman
N J
NJ
D000818:Animals; D002465:Cell Movement; D002923:Cilia / Q000473:pathology / Q000648:ultrastructure; D002925:Ciliary Motility Disorders / Q000097:blood / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood* / Q000276:immunology / Q000473:pathology; D004285:Dogs; D005260:Female; D008213:Lymphocyte Activation; D008854:Microscopy, Electron; D009504:Neutrophils / Q000276:immunology / Q000382:microbiology / Q000502:physiology*; D010587:Phagocytosis; D012137:Respiratory System / Q000473:pathology* / Q000648:ultrastructure; D013211:Staphylococcus aureus / Q000276:immunology