title: Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation.
abstract: The structure of a new pancreatic lipase inhibitor, lipstatin, produced by Streptomyces toxytricini was determined as (2S,3S,5S,7Z,10Z)-5-[(S)-2-formamido-4-methylpentanoyloxy ]-2-hexyl-3- hydroxy-7,10-hexadecadienoic lactone by spectroscopic and chemical methods. Structurally lipstatin is closely related to the known esterase inhibitor esterastin. It contains a N-formyl-L-leucine side chain instead of the N-acetyl-L-asparagine in esterastin.
authors: Central Research Units, F. Hoffmann-La Roche & Co., Ltd., Basel, Switzerland.
authors: E
authors: E
authors: Hochuli
authors: E
authors: E
authors: Kupfer
authors: R
authors: R
authors: Maurer
authors: W
authors: W
authors: Meister
authors: Y
authors: Y
authors: Mercadal
authors: K
authors: K
authors: Schmidt
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D004791:Enzyme Inhibitors; D007783:Lactones; D008049:Lipase / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000032:analysis*
chemical_list: D004791:Enzyme Inhibitors; D007783:Lactones; D008049:Lipase