Nutritional dependence of the effect of estrogen on fat cell lipoprotein lipase.
We investigated the effects of ethynylestradiol (EE) at low dose (1.2 micrograms/day) injected s.c. for 10 days on lipoprotein lipase (LPL) in fat cells of female rats fed a standard diet (5% lipid, 49.5% glucid, 23.5% protein) as a function of the nutritional state. EE caused a 150% increase in LPL activity in the fed state, and a 65% decrease in the fasting state, resulting in a large increment in the physiological feeding-fasting difference. Feeding the rats a diet supplemented with 20% lard reversed the estrogen-dependent LPL increase in the fed state. Under all experimental conditions, EE caused a depletion of fat stores and an increase in plasma levels of triacyglycerol.
Valette
A
A
U.260, Institut National de la Santé et de la Recherche Médicale, Faculté de Médecine, Marseille, France.
Mercier
L
L
Benoit
V
V
Meignen
J M
JM
Boyer
J
J
D000273:Adipose Tissue / Q000187:drug effects / Q000201:enzymology*; D000818:Animals; D004041:Dietary Fats / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005215:Fasting; D005260:Female; D005502:Food; D008071:Lipoprotein Lipase / Q000378:metabolism*; D009752:Nutritional Status; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
D004041:Dietary Fats; D014280:Triglycerides; D004997:Ethinyl Estradiol; D008071:Lipoprotein Lipase