title: Gamma-aminobutyric acid- and picrotoxin-induced changes in c-wave and light peak of retinal potentials in the chick.
abstract: Retinal potentials were recorded from the eyes of anesthetized and immobilized chicks by a standard direct current method. The amplitude of the electroretinogram (ERG) c-wave was measured 2 and 5 sec after the onset of the light stimulus, as indexes of the fast-rise c-wave (cF-wave) and the slow-rise c-wave (cS-wave), respectively. An intravitreal injection of gamma-aminobutyric acid (GABA) at an estimated intravitreal concentration of 10(-9)-10(-7) M resulted in an increase of the amplitude of the cS-wave, a less remarkable change in the a- and cF-waves, and a slight decrease in the b-wave. The light peak of the retinal standing potential increased in amplitude following GABA administration (10(-7)-10(-4) M). Following an intravitreal injection of picrotoxin (10(-5)-10(-3) M), the polarity of the cS-wave changed from positive to negative and a significant decrease and deformation in the light peak was observed. The amplitude of the a-wave, however, increased in the range of the higher dose, while that of the b- and cF-waves decreased markedly but no polarity reversal of the cF-wave was found. The results may suggest that the GABA-ergic synapse plays a significant role in production of the cS-wave and the light peak, along with that of the pigment epithelium.
authors: Department of Physiology, School of Dentistry, Iwate Medical University, Japan.
authors: T
authors: T
authors: Sato
authors: T
authors: T
authors: Yoneyama
authors: H K
authors: HK
authors: Kim
authors: N
authors: N
authors: Matsumoto
authors: T A
authors: TA
authors: Suzuki
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004596:Electroretinography; D010852:Picrotoxin / Q000494:pharmacology*; D012160:Retina / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid