[Substantiation of daily permissible levels of cadmium intake with food].
A chronic experiment was conducted in rats which were given cadmium in doses 100, 10 and 1 microgram/kg (as salt or in the metadolized form) with food, daily, during 6 months. Biochemical studies were based on the parameters characterizing the functions of the liver, kidneys, gastro-intestinal tract, pancreas, CNS, prostate (in males). Pathomorphological investigations were made at the end of the experiment. No significant differences were recorded in the action on the body of metabolized cadmium and cadmium salt. Cadmium in a dose of 100 micrograms/kg induced the development of anemia, renal insufficiency, suppression of the activity of digestive enzymes and dystrophic changes in the liver, kidneys and testes. Cadmium in a dose of 1 microgram/kg proved to be inactive, and it is recommended as a daily safe dose of cadmium intake with food.
Karpliuk
I A
IA
Volkova
N A
NA
Popov
V I
VI
Stepanova
E N
EN
D000818:Animals; D002105:Cadmium Poisoning; D005506:Food Contamination; D005517:Foodborne Diseases; D007928:Lethal Dose 50; D008297:Male; D008452:Maximum Allowable Concentration; D051381:Rats
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