[Effect of selected anesthetics on serum myoglobin levels after administration of succinylcholine. Comparison of halothane, enflurane and isoflurane with thiopental in adults].
The type of anesthetic agent used influences the extent of the increase in serum myoglobin concentrations brought about by succinylcholine (sch). The purpose of this study was to compare the inhalational agents halothane, isoflurane, and enflurane with i.v. thiopental with respect to their effects on serum myoglobin levels following sch. Twenty-four male adults undergoing surgical procedures involving no muscle trauma were randomized and divided into four groups of six each. Following induction of anesthesia with a bolus injection of thiopental 2.5-3.5 mg/kg, patients in the four groups received either repetitive doses of thiopental plus N2O/O2 (4 l/min; FiO2 0.3) or one of the inhalational agents in N2O/O2 in dosages necessary for maintenance. Ventilation was carried out according to clinical judgement. Following a pre-sch phase of 15 min, sch 1 mg/kg was injected intravenously. Blood samples for determining myoglobin (normal range 30-60 ng/ml) were taken immediately prior to (control values) and 5 and 15 min after sch injection. Increases were defined as the difference of two values 15 min prior to and after sch. Statistical analysis was carried out by way of ANOVAs, P less than 0.05 being considered significant. The mean values of myoglobin prior to sch ranged from 52.3 to 57.7 ng/ml according to group (Table 1). The increase in concentration normally ranged from 1 to 7 times pre-sch levels, in some cases to 20 times. Table 2 shows the mean values. The type of anesthetic agent exerted no significant influence on serum concentration.
Plötz
J
J
Institut für Anästhesiologie, Klinikum Bamberg.
Braun
J
J
D000328:Adult; D000768:Anesthesia, General; D004737:Enflurane / Q000494:pharmacology*; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D009211:Myoglobin / Q000097:blood*; D011188:Potassium / Q000097:blood; D013390:Succinylcholine / Q000494:pharmacology*; D013874:Thiopental / Q000494:pharmacology*
D009211:Myoglobin; D004737:Enflurane; D007530:Isoflurane; D013390:Succinylcholine; D013874:Thiopental; D011188:Potassium; D006221:Halothane
Der Einfluss ausgewählter Narkotika auf die Serumkonzentration von Myoglobin nach Gabe von Succinylcholin. Ein Vergleich von Halothan, Enfluran und Isofluran mit Thiopental bei Erwachsenen.