title: Absolute bioavailability of metoclopramide given orally or by enema in patients with normal liver function or with cirrhosis of the liver.
abstract: Single dose studies were performed with three different dosage forms of metoclopramide (0.25 mg/kg body weight) in patients with normal liver function (i.v. (Paspertin): n = 4, oral liquid preparation: n = 4, rectal micro-enema n = 4) and patients with histologically confirmed cirrhosis of the liver (i.v.: n = 6, oral liquid preparation n = 4, rectal micro-enema: n = 8). Drug plasma-concentrations were measured over 8 h by a specific gas chromatographic method. The median areas under the plasma concentration-time curves (AUC0-8) after i.v. and rectal administration were similar in both groups. In contrast, the median oral bioavailability was considerably higher in patients with cirrhosis of the liver (82%) than in patients with normal liver function (60%). It can be concluded from this study, that dosage adjustments may be necessary in oral treatment of patients with cirrhosis of the liver, especially if prolonged therapy is required.
authors: Zentrum der Inneren Medizin, Klinikum der Universität, Frankfurt/Main, Fed. Rep. of Germany.
authors: A
authors: A
authors: Hellstern
authors: D
authors: D
authors: Hellenbrecht
authors: R
authors: R
authors: Saller
authors: M
authors: M
authors: Gatzen
authors: B
authors: B
authors: Manus
authors: G
authors: G
authors: Achtert
authors: P
authors: P
authors: Brockmann
authors: H J
authors: HJ
authors: Hausleiter
authors: U
authors: U
authors: Leuschner
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001682:Biological Availability; D004733:Enema; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008103:Liver Cirrhosis / Q000378:metabolism*; D008111:Liver Function Tests; D008787:Metoclopramide / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D008787:Metoclopramide