The activity of purified Bordetella pertussis components in murine encephalopathy.
A murine encephalopathic syndrome can be induced by the administration of BSA and whole-cell pertussis vaccine. The present paper reports studies of the capacity of purified individual pertussis components to induce this effect. Pertussis toxin and endotoxin together with a highly immunogenic sensitizer protein were required to induce the effect. The strength of the antibody response to the sensitizer appeared to be more important than the H-2 type of the recipient in determining the susceptibility of different mouse strains. The relevance of this syndrome to the study of possible vaccine-induced encephalopathy in man is uncertain and requires further investigation.
Redhead
K
K
Division of Bacteriology, National Institute for Biological Standards and Control, Hampstead, London, UK.
Robinson
A
A
Ashworth
L A
LA
Melville-Smith
M
M
D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced* / Q000276:immunology / Q000382:microbiology; D004195:Disease Models, Animal; D004731:Endotoxins / Q000633:toxicity; D005260:Female; D007114:Immunization; D008070:Lipopolysaccharides / Q000008:administration & dosage; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D037342:Pertussis Toxin; D010567:Pertussis Vaccine / Q000009:adverse effects*; D012710:Serum Albumin, Bovine / Q000008:administration & dosage; D013577:Syndrome; D010566:Virulence Factors, Bordetella / Q000032:analysis / Q000633:toxicity*
D004731:Endotoxins; D008070:Lipopolysaccharides; D010567:Pertussis Vaccine; D010566:Virulence Factors, Bordetella; D012710:Serum Albumin, Bovine; D037342:Pertussis Toxin