[Prevention of ischemic myocardial damage by reducing the intracellular free carnitine level].
3-(2, 2, 2-trimethylhydrazinium) propionate (THP) inhibits gamma-butyrobetaine hydroxylase, which is accompanied by a drop in myocardial free carnitin content. In rabbits, 200 mg/kg THP, administered intraperitoneally for 10 days, decreases free carnitin and long-chain acylcarnitin by 59.8 and 59.2%, respectively. In a carnitin-depressing dose, THP helps to recover contractility of isolated atria after hypoxic exposure. THP prevents isoproterenol-induced accumulation of long-chain acylcarnitin and ATR fall in the rat myocardium. The protective effect of THP is realized in the presence of considerably reduced (by an average of 77.8%) myocardial free carnitin levels. Inhibition of carnitin-dependent fatty acids metabolism by reducing intracellular carnitin concentration is a pathogenetically justified method of myocardial protection against ischemic damage.
Simkhovich
B Z
BZ
Vitolinia
R O
RO
Stivrinia
M I
MI
Shutenko
Zh V
ZhV
Meĭrena
D V
DV
D000818:Animals; D002331:Carnitine / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003327:Coronary Disease / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology*; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D050563:gamma-Butyrobetaine Dioxygenase
D008763:Methylhydrazines; C050147:3-(2,2,2-trimethylhydrazine)propionate; D006899:Mixed Function Oxygenases; D050563:gamma-Butyrobetaine Dioxygenase; D002331:Carnitine
Predotvrashchenie ishemicheskikn povrezhdenii miokarda putem znizheniia vnutrikletochnoi kontsentratsii svobodnogo karnitina.