[Effect of dibunol on lipid peroxidation and alpha-tocopherol levels in the rat liver in myocardial infarction].
Lipid peroxidation in rat liver tissue homogenate was studied by evaluation of diene conjugates and Schiff bases content within 24 hrs after myocardium infarction. Tocopherol was estimated using spectrofluorimetric procedure. Ionol was administered intraperitoneally at a dose of 120 mg/kg within 15 min after the left coronary artery ligation. In the myocardium infarction content of diene conjugates was increased 2-fold and of Schiff bases--2.5-fold in liver tissue, while content of tocopherol was decreased 1.7-fold. Ionol prevented the increase of lipid peroxidation products and the tocopherol content decrease. This antioxidant proved to be effective drug at the initial steps of myocardium infarction as well as it exhibited the distinctly protective effect on liver tissue. The protective effect of ionol appears to occur not only due to its antioxidant properties and the ability to restrict stress reactions but also in response to rapid accumulation in liver tissue. The data obtained suggest that lipid peroxidation in liver tissue may be one of mechanisms responsible for metabolism impairment in myocardium infarction; treatment with the antioxidant ionol is the effective pathogenetic mean for correction of these disorders.
Davydov
B V
BV
Golikov
P P
PP
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012545:Schiff Bases / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism*
D008054:Lipid Peroxides; D012545:Schiff Bases; D014810:Vitamin E; D002084:Butylated Hydroxytoluene
Vliianie dibunola na perekisnoe okislenie lipidov i uroven' alpha-tokoferola v pecheni krys pri infarkte miokarda.