A new pyrrole-amidine antibiotic TAN-868 A.
A new pyrrole-amidine antibiotic TAN-868 A was isolated from the culture broth of Streptomyces idiomorphus sp. nov. Its chemical structure was determined by spectroscopic analyses and degradation studies to be 4-[(2S,4R)-4-hydroxy-5-iminoprolyl]amino- N-(2-amidinoethenyl)-2-pyrrolecarboxamide. The antibiotic is active against bacteria, fungi and a protozoan, and has cytotoxic activity against murine tumor cells. DNA thermal denaturation studies suggest that TAN-868 A preferentially interacts with AT rich regions of double-stranded DNA.
Takizawa
M
M
Applied Microbiology Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan.
Tsubotani
S
S
Tanida
S
S
Harada
S
S
Hasegawa
T
T
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D009691:Nucleic Acid Denaturation; D011061:Poly A / Q000378:metabolism; D011071:Poly T / Q000378:metabolism; D011758:Pyrroles / Q000302:isolation & purification / Q000378:metabolism; D013302:Streptomyces / Q000032:analysis; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D011758:Pyrroles; C054275:antibiotic TAN 868 A; D011061:Poly A; D011071:Poly T; C008950:poly A-T; C054264:kikumycin A; D004247:DNA