title: [Effect of therapeutic administration of purine derivatives on the life span of irradiated animals].
abstract: Purine derivatives, meradine and ethimizole, are shown to exert a therapeutic effect with respect to survival of rats exposed to 4 Gy radiation. Distinctions in the death rate between the exposed rats and rats treated with meradine and ethimizole are manifested 1 month following irradiation, i. e. at the time of clinical recovery of the exposed body. The preparations used at other te terms are uneffective. It is suggested that purine derivatives increase the regeneration and compensation of radiation lesions at the time of clinical recovery reducing an irreversible component of radiation damage.
authors: E A
authors: EA
authors: Prokudina
authors: A E
authors: AE
authors: Borovitskaia
authors: N O
authors: NO
authors: Kadyrova
authors: L P
authors: LP
authors: Rzhononitskaia
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D005042:Etimizol / Q000627:therapeutic use*; D007031:Hypothalamus / Q000378:metabolism / Q000528:radiation effects; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality*; D011837:Radiation-Protective Agents; D051381:Rats; D013997:Time Factors
chemical_list: D002395:Catecholamines; D007093:Imidazoles; D011837:Radiation-Protective Agents; C001700:meradine; D000225:Adenine; D005042:Etimizol
vernacular_title: Vliianie terapevticheskogo primeneniia purinovykh proizvodnykh na prodolzhitel'nost' zhizni obluchennykh zhivotnykh.