title: Metabolism of manganese in calves as affected by dietary manganese and intravenous or duodenal manganese-54 dosing.
abstract: Fifteen intact male Holstein calves averaging 101 d of age were utilized to determine the effects of dietary Mn concentration and routes of administration on its metabolism. They were fed a practical grain diet containing 23 ppm Mn with 0, 100, or 1000 ppm supplemental Mn (MnSO4.H2O) for 7 d prior to intravenous or duodenal dosing with 54Mn. Animals were killed 4 h later. With added Mn there was a significant decrease in 54Mn content of some small intestine parts. However, in most tissue, including organs, bones, intestinal tract tissues, and blood, added Mn did not have a significant effect on 54Mn concentrations. Concentrations of 54Mn in tissues, except in small intestine, were far higher following intravenous dosing than with duodenal dosing. This further confirms that absorption of Mn is very low. Dosing method had a sizable effect on the relative amounts of 54Mn in different tissues. This suggests that intravenously administered Mn, at least initially, is not metabolized in the same way as that absorbed. In most tissues, unlabeled Mn was not affected greatly by supplemental Mn. This is in contrast to earlier results with very young calves and indicates that Mn metabolism changes sharply before 3 to 4 mo of calf age.
authors: Department of Animal and Dairy Science, University of Georgia, Athens 30602.
authors: W J
authors: WJ
authors: Miller
authors: P E
authors: PE
authors: Stake
authors: M W
authors: MW
authors: Neathery
authors: R P
authors: RP
authors: Gentry
authors: D M
authors: DM
authors: Blackmon
mesh_terms: D000818:Animals; D002417:Cattle / Q000378:metabolism*; D004032:Diet; D004386:Duodenum / Q000187:drug effects; D007275:Injections, Intravenous; D008297:Male; D008345:Manganese / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology; D011868:Radioisotopes / Q000008:administration & dosage / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D011868:Radioisotopes; D008345:Manganese