title: Comparative bioavailability study of two preparations of alpha-methyldopa after single, oral doses.
abstract: Bioavailability of alpha-methyldopa from a film coated tablet Dopegyt (EGIS Pharmaceutical Works, Budapest, Hungary) and from Aldometil (MSD, Sharp and Dohme GmbH, Munich, FRG) containing 250 mg of effective substance, was investigated in a crossover study in six patients with mild hypertension having normal renal and liver functions. Alpha-methyldopa was determined in plasma by fluorometry. There was no difference in the pharmacokinetic parameters calculated (Cl, Vd, AUC, t1/2) indicating that the two preparations are bioequivalent.
authors: Postgraduate Medical School, 1st Department of Internal Medicine, Budapest, Hungary.
authors: K
authors: K
authors: Róna
authors: B
authors: B
authors: Gachályi
authors: L
authors: L
authors: Vereczkey
authors: B
authors: B
authors: Nádas
authors: A
authors: A
authors: Káldor
mesh_terms: D000328:Adult; D001682:Biological Availability; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008750:Methyldopa / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D008750:Methyldopa