Bilateral posterior choanal atresia: a morphologic and histologic study, and computed tomographic correlation.
Bilateral posterior choanal atresia is an uncommon cause of respiratory obstruction in the newborn. Although the clinical syndrome and treatment options are well known, the abnormal histology has not been well described. Computed tomography (CT) is a useful tool in the radiologic diagnosis of choanal atresia, but has not been correlated with the histopathology. Two patients with CHARGE association (congenital heart defects, choanal atresia, retarded growth and development, hypogenitalism, and aural anomalies) and bilateral posterior choanal atresia were studied with CT. The atresia plates were removed at autopsy and sectioned in an axial plane for gross and microscopic study. The histopathology is described and correlated with the CT studies. These studies show that CT accurately defines the histopathologic abnormalities found in bilateral posterior choanal atresia.
Brown
O E
OE
Department of Otorhinolaryngology, University of Texas Health Science Center at Dallas 75235.
Burns
D K
DK
Smith
T H
TH
Rutledge
J C
JC
D000015:Abnormalities, Multiple; D002754:Choanal Atresia / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D014057:Tomography, X-Ray Computed