The anti-emetic properties of 1-sulpiride in a ground-based model of space motion sickness.
L-sulpiride, at a dose of 4 mg/kg, essentially abolished motion-induced emesis in a group of 6 squirrel monkeys undergoing horizontal rotation at 25 rpm, a terrestrial model of space motion sickness (SMS). Extrapyramidal side effects were not observed. In the absence of the drug, the usual emetic response returned. In comparison while typical neuroleptics were also strongly anti-emetic, they produced a considerable degree of rigidity and akinesia.
Miller
J D
JD
Department of Animal Physiology, University of California, Davis 95616.
Brizzee
K R
KR
D000818:Animals; D000932:Antiemetics; D002746:Chlorpromazine / Q000627:therapeutic use; D004195:Disease Models, Animal; D004294:Domperidone / Q000627:therapeutic use; D005260:Female; D008297:Male; D009041:Motion Sickness / Q000188:drug therapy*; D011346:Prochlorperazine / Q000627:therapeutic use; D012453:Saimiri; D013469:Sulpiride / Q000627:therapeutic use*; D013847:Thiethylperazine / Q000627:therapeutic use; D014273:Triflupromazine / Q000627:therapeutic use
D000932:Antiemetics; D004294:Domperidone; D013469:Sulpiride; D013847:Thiethylperazine; D014273:Triflupromazine; D002746:Chlorpromazine; D011346:Prochlorperazine