Monoclonal antibodies against synthesized short peptides corresponding to human AA amyloid protein.
Monoclonal antibodies (McAbs) were raised against the synthesized short peptides corresponding to 37-47 residues in amino acid sequence of human AA protein. The McAbs reacted immunohistochemically to amyloid tissues from cow, mouse, swan, and human AA amyloidosis. We concluded that the McAbs were useful for identification of AA type amyloidosis of various species, and that the 37-47 residues were effective antigenic sites in AA protein.
Yokota
T
T
First Department of Pathology, Yamaguchi University School of Medicine, Japan.
Ishihara
T
T
Takahashi
M
M
Yamashita
Y
Y
Kawano
H
H
Fujinaga
Y
Y
Uchino
F
F
Hanai
N
N
Yoshida
H
H
Honda
S
S
D000595:Amino Acid Sequence; D000686:Amyloidosis / Q000473:pathology* / Q000662:veterinary; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001717:Birds; D002417:Cattle; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D051379:Mice; D000685:Serum Amyloid A Protein / Q000032:analysis / Q000276:immunology*; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D000685:Serum Amyloid A Protein