title: Alterations in tissue Mg++, Na+ and spinal cord edema following impact trauma in rats.
abstract: Alterations in water content and total tissue Na+ and Mg++ of rat spinal cord tissue were followed over time after a 100 g-cm impact injury to the T-9 spinal cord segment. Rats subjected to laminectomy but not trauma served as controls. In the injured segment there was a progressive increase in water content with increased Na+ and decreased Mg++ at 1 hour and 24 hours after trauma. At seven days, water and Na+ content remained elevated, whereas Mg++ levels had returned to preinjury baseline values. Because of its important role in many metabolic and physiological regulatory processes the early decline in Mg++ concentration after trauma may contribute to the development of secondary tissue damage after spinal cord injury.
authors: Department of Neurology, University of California, San Francisco.
authors: M
authors: M
authors: Lemke
authors: P
authors: P
authors: Demediuk
authors: T K
authors: TK
authors: McIntosh
authors: R
authors: R
authors: Vink
authors: A I
authors: AI
authors: Faden
mesh_terms: D000818:Animals; D001834:Body Water / Q000378:metabolism; D004487:Edema / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D013119:Spinal Cord Injuries / Q000378:metabolism*; D014882:Water-Electrolyte Balance
chemical_list: D012964:Sodium; D008274:Magnesium