title: Enlargement of melanocytic iris lesions.
abstract: We evaluated the natural history of 175 melanocytic lesions (nevus or melanoma) of the iris which were managed initially by observation without surgical intervention. Only eight of the 175 lesions (4.6%) enlarged during a median follow-up interval of 3.9 years. Univariate Cox regression analysis revealed that tumor location in the medical portion of the iris (P = 0.047) and pigment dispersion from the lesion onto the adjacent iris and trabecular meshwork (P = 0.056) were the only significant clinical conditions predictive of tumor enlargement. Based on these findings, we recommend conservative management of most melanocytic lesions of the iris.
authors: Oncology Service, Wills Eye Hospital, Philadelphia, Pennsylvania 19107.
authors: C
authors: C
authors: Territo
authors: J J
authors: JJ
authors: Augsburger
authors: R P
authors: RP
authors: Schroeder
authors: J A
authors: JA
authors: Shields
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007499:Iris Diseases / Q000473:pathology*; D008297:Male; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged; D009506:Nevus / Q000473:pathology*; D012044:Regression Analysis; D014604:Uveal Neoplasms / Q000473:pathology*