[Uncoupled oxidation in rat heart mitochondria].
Isolated heart mitochondria possessing a high phosphorylation efficiency with pyruvate and malate as substrates oxidize NADH and ascorbate unassociated with ADP phosphorylation. This uncoupled pathway is expressed partially when succinate or NAD-linked substrates are oxidized. The uncoupled oxidation is likely to be the result of the presence of a mitochondrial population with the high-permeable inner membrane in intact tissues. The nature and origin of a uncoupled respiratory system and its role in the thermoproduction of endotherms are discussed.
Akhmerov
R N
RN
D000818:Animals; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000378:metabolism; D008564:Membrane Potentials; D008929:Mitochondria, Heart / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats; D013379:Substrate Specificity; D014475:Uncoupling Agents / Q000494:pharmacology*
D014475:Uncoupling Agents
O nesopriazhennom okislenii v mitokhondriiakh serdtsa krysy.