Beta-oxidation of N-nitrosodiethanolamine in different animal species in vitro and in vivo.
The metabolism of N-nitrosodiethanolamine (NDELA) was studied to assess whether the formation of the beta-oxidized metabolites, N-nitroso(2-hydroxyethyl) (formylmethyl)amine (NHEFMA) and N-nitroso(2-hydroxyethyl)(carboxymethyl)amine (NHECMA), is involved in tumour induction in various animal species with different susceptibilities to NDELA carcinogenicity. In-vitro and in-vivo studies showed that all the animal species considered metabolize NDELA through the beta-oxidation pathway, suggesting that there is no correlation between carcinogenesis by NDELA and its beta-oxidation.
Bonfanti
M
M
Laboratory of Environmental Pharmacology and Toxicology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Magagnotti
C
C
Fanelli
R
R
Airoldi
L
L
D000818:Animals; D006224:Cricetinae; D004052:Diethylnitrosamine / Q000031:analogs & derivatives* / Q000378:metabolism; D051379:Mice; D010084:Oxidation-Reduction; D051381:Rats; D013045:Species Specificity
C014129:N-nitrosodiethanolamine; D004052:Diethylnitrosamine