High dose ketoconazole in the treatment of cerebral aspergilloma.
A 32-year-old Chinese woman with bilateral occipital aspergilloma was treated successfully with high dose ketoconazole (1200 mg/day) for six months in conjunction with amphotericin B and 5-fluorocytosine. No unacceptable side effects occurred. The use of high dose ketoconazole could be considered in CNS aspergillosis unresponsive to conventional anti-fungal therapy.
Kwong
Y L
YL
University Department of Medicine, Queen Mary Hospital, Hong Kong.
Yu
Y L
YL
Chan
F L
FL
Lam
K S
KS
Woo
E
E
Huang
C Y
CY
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001927:Brain Diseases / Q000188:drug therapy* / Q000382:microbiology; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D006723:Hong Kong; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
D000666:Amphotericin B; D005437:Flucytosine; D007654:Ketoconazole