title: Effects of estradiol benzoate on apomorphine-induced pecking behavior in the pigeon.
abstract: Clinical and laboratory observations suggested an interaction between sex hormones and dopaminergic functions. Estrogens are reported to exert dual effects on dopaminergic system(s). In the apomorphine-induced pecking behavior model in the pigeon, acute administration of estradiol benzoate (5, 10, 20 mg/kg) significantly reduced the total pecking counts, indicating an antidopaminergic effect. Other sex steroids, testosterone and progesterone were found to be ineffective. Chronic administration of low dose estradiol benzoate (20 micrograms/kg/day) resulted in an increase in total pecking counts elicited by a single dose of apomorphine administration, revealing an increased sensitivity in dopaminergic functions.
authors: Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors: O
authors: O
authors: Akbas
authors: R
authors: R
authors: Onur
authors: T
authors: T
authors: Verimer
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D010856:Columbidae; D003216:Conditioning, Operant / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D008297:Male; D011239:Prednisolone / Q000494:pharmacology; D011374:Progesterone / Q000494:pharmacology; D013739:Testosterone / Q000494:pharmacology
chemical_list: D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D011239:Prednisolone; D001058:Apomorphine