Basophilic leukaemia in a dog.
Leukaemia in an 11-year-old bitch was characterized by the presence in the peripheral blood and bone marrow of cells with lobulated nuclei and numerous metachromatic cytoplasmic granules. The results of cytochemical stains for peroxidase and naphthol AS-D chloracetate esterase activity were negative. Ultrastructurally, the cytoplasmic granules were finely granular with no membranous coils or crystalline lattice structures. Based on these findings, the neoplastic cells were classified as basophils.
Mahaffey
E A
EA
Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602.
Brown
T P
TP
Duncan
J R
JR
Latimer
K S
KS
Brown
S A
SA
D000818:Animals; D001491:Basophils / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology; D002462:Cell Membrane / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D003594:Cytoplasmic Granules / Q000473:pathology; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006651:Histocytochemistry; D007938:Leukemia / Q000473:pathology / Q000662:veterinary*; D008099:Liver / Q000473:pathology; D008854:Microscopy, Electron; D013154:Spleen / Q000473:pathology