Nuclear DNA changes during pathogenesis of squamous carcinoma of the cervix in 3,4-benzopyrene-treated mice.
The pathogenesis of squamous carcinoma of the uterine cervix was studied by means of morphologic and cytochemical techniques in mice treated with 3,4-benzopyrene. The results indicate that carcinogen-induced transformation of normal cervical epithelium into squamous carcinoma occurs through a sequence of cellular alterations, demonstrated by progressively increasing cellular atypia and a progressively increasing and scattered DNA content.
Näslund
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I
Department of Oncology, Karolinska Institute and Hospital, Stockholm, Sweden.
Rubio
C A
CA
Auer
G U
GU
D000818:Animals; D001564:Benzo(a)pyrene; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology*; D002467:Cell Nucleus / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000473:pathology*
D004273:DNA, Neoplasm; D001564:Benzo(a)pyrene