title: Factors producing elevated core temperature in spontaneously hypertensive rats.
abstract: Core temperature (Tco) of the spontaneously hypertensive rat (SHR) is consistently higher by approximately 1 degree C than that of normotensive controls. To analyze factors producing the elevated Tco, mean skin temperature (Tsk), metabolic heat production (M), respiratory evaporative heat loss (Eres), effective tissue thermal conductance (K), systolic blood pressure (BP), and Tco were determined in eight male SHR and nine male normotensive Wistar-Kyoto (WKY) rats habituated to rest quietly in neck stock restraint while exposed to ambient temperatures (Ta) of 12.5, 17, 23, 28.5, 32, 34, and 35 degrees C. At all temperatures steady-state BP, Tco, and M were higher for SHR's than for WKY's. SHR's could maintain thermal balance up to Ta 32 degrees C, and WKY's up to 34 degrees C. Eres from SHR's was greater than from WKY's at Ta of 12.5, 17, and 28.5 degrees C. K of SHR's was not different from or was higher than K of WKY's, and K for both groups was 2.6 times greater at Ta 32 degrees C than at 17 degrees C. These results indicate that the high Tco of SHR's is due to increased M uncompensated by increased K or Eres.
authors: Physiology Department, Southern Illinois University, Carbondale 62901.
authors: M G
authors: MG
authors: Collins
authors: W S
authors: WS
authors: Hunter
authors: C M
authors: CM
authors: Blatteis
mesh_terms: D000818:Animals; D001831:Body Temperature; D001833:Body Temperature Regulation; D005334:Fever / Q000209:etiology*; D006185:Habituation, Psychophysiologic; D006973:Hypertension / Q000150:complications*; D008297:Male; D008433:Mathematics; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012149:Restraint, Physical