title: Influence of vehicle on antimicrobial efficiency of topical dosage forms of chloramphenicol.
abstract: Antimicrobial efficiency of chloramphenicol incorporated into ambiphilic emulsion bases was investigated, and it was shown that the efficiency was several times greater than the efficiency of a comercially available lipophilic dosage form. The efficiency was especially pronounced when the samples with a higher aqueous-phase content and of a lower viscosity were used. All ambiphilic preparations were stable when stored at 4 degrees C for 6 months, and when storage time was prolonged up to 1 year the most stable formulations were those which were prepared with a mixture of Tagat S and Tegin M.
authors: Faculty of Pharmacy and Biochemistry, University of Zagreb.
authors: M
authors: M
authors: Cajkovac
authors: M
authors: M
authors: Kupinic
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D002701:Chloramphenicol / Q000008:administration & dosage / Q000494:pharmacology*; D004655:Emulsions; D008826:Microbial Sensitivity Tests; D014677:Pharmaceutical Vehicles
chemical_list: D004655:Emulsions; D014677:Pharmaceutical Vehicles; D002701:Chloramphenicol