Measurement of right ventricular volumes from ECG-gated steady-state krypton-81m angiocardiography.
The physical characteristics of krypton-81m makes it particularly suited for the study of right ventricular function, but its ultrashort half-life (13.3 s) precludes in vitro measurements of blood pool specific activity needed for count based determination of ventricular volumes. A combined geometric count based method was developed to measure absolute right ventricular volumes during steady state krypton-81m angiocardiography: background corrected ventricular count rates were converted to volumes using a count to volume calibration factor calculated in an 'internal reference ROI' located in the right ventricular outflow tract. Stroke volumes calculated with this method were shown to be comparable to thermodilution determined stroke volumes and the ability of the method to monitor changes in right ventricular volumes was demonstrated during intervention studies.
Franken
P R
PR
Hôpital Universitaire Saint Pierre, Bruxelles, Belgium.
Mols
P
P
Delcourt
E
E
Dobbeleir
A
A
Georges
B
B
Ham
H R
HR
D000790:Angiocardiography; D004562:Electrocardiography; D006321:Heart / Q000502:physiology*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000494:pharmacology; D007726:Krypton; D009068:Movement; D011187:Posture; D013318:Stroke Volume / Q000187:drug effects; D016276:Ventricular Function
D007726:Krypton; D007548:Isosorbide Dinitrate