[Changes in the behavioral and biochemical effects of cerulein, an analog of cholecystokinin octapeptide, after prolonged administration of haloperidol].
In experiments on male mice and rats, long-term haloperidol administration (0.25 mg/kg twice a day during 15 days) significantly changed behavioural effects of caerulein, an agonist of CCK-8 receptors. As a rule, the effects of caerulein were reduced or inverted; only long-term antagonism with amphetamine motor excitation in rats increased after the cessation of haloperidol administration. The decrease or inversion of caerulein's effects was connected with reduction of high-affinity dopamine2- and low-affinity CCK-8 receptors' density, reflecting the inhibition of some interneurons' activity in subcortical forebrain structures after haloperidol treatment. A more pronounced inhibition of dopamine's release by caerulein was the reason for the increased antiamphetamine action after long-term haloperidol treatment. It seems possible that both above mechanisms are involved in the antipsychotic action of haloperidol.
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D000818:Animals; D000927:Anticonvulsants; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D002108:Ceruletide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011949:Receptors, Cholecystokinin / Q000187:drug effects*; D012844:Sincalide / Q000378:metabolism
D000927:Anticonvulsants; D011949:Receptors, Cholecystokinin; D002108:Ceruletide; D006220:Haloperidol; D012844:Sincalide
Izmenenie povedencheskikh i biokhimicheskikh éffektov tseruleina, analoga oktapeptida kholetsistokinina, posle dlitel'nogo vvedeniia galoperidola.