[Time dependence of the shedding of class I and II HLA antigens. Interrelation of the fluctuations of HLA-antigen shedding and 51Cr-labeled macromolecules].
Soluble HLA-A, -B and -DR antigens were determined every 10 min with a rate nephelometry method in supernatants of human mononuclear cells cultured for 3 hrs. The time-dependent oscillations in the quantity of soluble HLA antigens with ultradian (circadian) rhythm characteristics were found. Quantity oscillations of HLA-A antigens were synphase to HLA-B ones and antiphase to HLA-DR antigens. Amplitude characteristics were found to depend on the temperature and cytoskeleton activity.
Musatov
M I
MI
Kozhevnikov
V S
VS
Konenkov
V I
VI
Lozovoĭ
V P
VP
D002860:Chromium Radioisotopes; D002940:Circadian Rhythm; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059947:HLA-B40 Antigen; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear / Q000276:immunology*
D002860:Chromium Radioisotopes; D006680:HLA Antigens; D015234:HLA-A Antigens; C037709:HLA-A9 antigen; D015235:HLA-B Antigens; D059947:HLA-B40 Antigen; D006684:HLA-DR Antigens
Zavisimost' shedinga HLA-antigenov I i II klassov ot vremeni. Sviaz' kolebaniĭ shedinga HLA-antigenov i mechennykh 51Cr makromolekul.