The prevalence of locally-synthesized virus antibodies in various forms of multiple sclerosis.
In 125 patients with multiple sclerosis, intrathecally synthesized antibodies against measles, rubella and zoster viruses were determined with an ELISA. 70% of patients with chronic progressive disease synthesized measles antibodies in comparison to 50% with a relapsing course. Women suffering from chronic progressive multiple sclerosis exhibited zoster antibodies 3 times as frequent as the other patients. These data indicate that relapsing and chronic progressive forms of multiple sclerosis exhibit different antiviral responses within the central nervous system which remain stable during the course of the disease.
Schädlich
H J
HJ
Neurologic University Clinic, Cologne, F.R.G.
Karbe
H
H
Felgenhauer
K
K
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood / Q000134:cerebrospinal fluid*; D005260:Female; D006562:Herpes Zoster / Q000276:immunology; D006801:Humans; D008297:Male; D008457:Measles / Q000276:immunology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D012409:Rubella / Q000276:immunology; D012737:Sex Factors
D000914:Antibodies, Viral