[Increase in the desialylated forms of serum transferrin and alcohol consumption].
In order to study a possible modification, secondary to alcohol consumption, of the distribution of various molecular forms of transferrin, we have compared its total serum concentration with that of several fractions in reference groups and excessive drinkers. The study was conducted in 50 patients; 35 drinkers admitted for detoxication, and 15 in the control group. The percentage of transferrin focalizing at pH 5.7 (Tf 5.7) is significantly higher in drinkers while the transferrin concentration is almost unchanged. During the weaning period, we observed a significant decrease of Tf 5.7 in two weeks. This parameter seems to be extremely sensitive regarding alcohol consumption; its specificity should be evaluated before coming to the conclusion that it present a definite advantage in the screening of excessive drinkers.
Schellenberg
F
F
Laboratoire de Biochimie, CHU Trousseau, Tours.
Weill
J
J
D000428:Alcohol Drinking / Q000502:physiology; D000437:Alcoholism / Q000097:blood*; D004591:Electrophoresis, Polyacrylamide Gel; D000431:Ethanol / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007525:Isoelectric Focusing; D019158:N-Acetylneuraminic Acid; D009439:Neuraminidase; D012794:Sialic Acids; D014168:Transferrin / Q000378:metabolism*
D012794:Sialic Acids; D014168:Transferrin; D000431:Ethanol; D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid
Augmentation des formes désialylées de la transferrine sérique et consommation d'alcool.