An acute study on the relative gastro-intestinal absorption of a novel form of calcium ascorbate.
Several functions of L-ascorbic acid (vitamin C) have been suggested in addition to its role in the prevention of scurvy. Consequently, a controversy has arisen over the daily intake of the vitamin which will afford maximum benefits. Rapid cellular uptake and delayed renal excretion of ascorbic acid would be conducive to providing optimum cellular concentration for biochemical activity. ESTER-C (patent pending), a complex consisting of L-ascorbic acid and Ca++, has been recently developed by Inter-Cal Corporation (421 Miller Road, Prescott, AZ 86301). It has been proposed that the structure of ESTER-C may render it more readily absorbed and less rapidly excreted than the acid or salt form of the vitamin. To test this hypothesis, ESTER-C and L-ascorbic acid were administered to two groups of rats. Blood was sampled at 20, 40, 80, 160 and 240 minutes and plasma analyzed for ascorbic acid. As urine appeared in collection cups, it was tested qualitatively for the presence of ascorbic acid. The plasma concentration of ascorbic acid was higher in ESTER-C treated rats at 20, 40 and 80 minutes than in rats given L-ascorbic acid. Ascorbic acid was detected in the urine of animals administered ESTER-C later than in those treated with L-ascorbic acid. These results support the hypothesis that ESTER-C is absorbed more readily and excreted less rapidly than L-ascorbic acid.
Bush
M J
MJ
Department of Pharmacology, School of Pharmacy, University of Mississippi, University 38677.
Verlangieri
A J
AJ
D000818:Animals; D001205:Ascorbic Acid / Q000493:pharmacokinetics*; D005753:Gastric Mucosa / Q000378:metabolism*; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001205:Ascorbic Acid