title: Down-regulation of phorbol diester binding to NG115-401L neuronal cells is dependent on structure, concentration and time.
abstract: The down-regulation of [3H]PDBu binding to a neural cell line, NG115-401L, has been examined in response to two biologically active phorbol diesters, PDBu and PMA. Chronic treatment with PDBu or PMA causes a concentration- and time-dependent loss of specific [3H]PDBu binding. The action of PMA is biphasic with respect to both concentration and time dependence.
authors: MRC Molecular Neurobiology Unit, University of Cambridge Medical School, England.
authors: R R
authors: RR
authors: Mattingly
authors: M L
authors: ML
authors: Dreher
authors: M R
authors: MR
authors: Hanley
mesh_terms: D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D009474:Neurons / Q000378:metabolism*; D010703:Phorbol Esters / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D011955:Receptors, Drug; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D010703:Phorbol Esters; D011955:Receptors, Drug; C083141:phorbol ester binding protein; C027776:phorbol ester receptor; D011493:Protein Kinase C