On phenotyping with isoniazid: the use of urinary acetylation ratio and the uniqueness of antimodes. Study of two Amerindian populations.
Various conventions have been used to express the activity of polymorphic hepatic N-acetyltransferase of isoniazid. Among them, two of the most common are the "percentage of acetylisoniazid" and the "inactivation index." A third alternative convention is proposed, the "molar acetylation ratio," which showed the most clear-cut bimodal distribution when applied to the results obtained for Cuna and Teribe Amerindians living in Panama. Through this method a unique antimode was assigned to each Amerindian group and the same frequency of slow acetylators (24% to 29%) was found, unlike the results obtained by conventional approaches and antimodes derived from white populations.
Inaba
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Department of Pharmacology, Faculty of Medicine, University of Toronto, Canada.
Arias
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D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007197:Indians, Central American; D007538:Isoniazid / Q000031:analogs & derivatives / Q000652:urine*; D008099:Liver / Q000201:enzymology; D008297:Male; D008722:Methods; D008875:Middle Aged; D010176:Panama; D010641:Phenotype; D013997:Time Factors
C006377:(N)1-acetylisoniazid; D000123:Acetyltransferases; D007538:Isoniazid