A QSAR study of the acute toxicity of some industrial organic chemicals to goldfish. Narcosis, electrophile and proelectrophile mechanisms.
1. A baseline toxicity QSAR model was derived for the 24-h LC50 to the goldfish, Carassius auratus. 2. The QSAR-predicted LC50 values for six epoxide derivatives were 2.8-985 times greater than measured. The excess toxicity of these epoxides and other compounds was ascribed to an electrophile molecular mechanism involving SN2 reaction with sulphydryl and other neucleophile groups present in enzymes and other biological macromolecules. 3. The excess toxicities of allyl alcohol and pentaerythritol triallyl ether were interpreted in terms of proelectrophile mechanisms. For the latter compound, this involves a monooxygenase-mediated free radical proton abstraction to a stable allyl radical. The allyl-free radical can undergo enzymic free radical hydroxylation to afford the corresponding acetal, which on decomposition yields the Michael acceptor electrophile acrolein.
Lipnick
R L
RL
US Environmental Protection Agency, Office of Toxic Substances, Washington, DC 20460.
Watson
K R
KR
Strausz
A K
AK
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003530:Cyprinidae / Q000502:physiology*; D004852:Epoxy Compounds / Q000633:toxicity*; D004988:Ethers, Cyclic / Q000633:toxicity*; D005609:Free Radicals; D006054:Goldfish / Q000502:physiology*; D007928:Lethal Dose 50; D006899:Mixed Function Oxygenases / Q000378:metabolism; D013329:Structure-Activity Relationship
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D005609:Free Radicals; D006899:Mixed Function Oxygenases