Isolation and characterization of the glutathione-elliptinium conjugate in human urine.
In a cancer patient given 100 mg/m2 elliptinium by intravenous infusion, the glutathione conjugate was found in urine. This metabolite was isolated after ion-exchange treatment and high performance liquid chromatography. Its structure was assessed by fast-atom bombardment mass spectrometry and comparison with an authentic sample.
Gouyette
A
A
Service de Pharmacologie Clinique, Institut Gustave-Roussy, Villejuif, France.
Voisin
E
E
Auclair
C
C
Paoletti
C
C
D000328:Adult; D000470:Alkaloids / Q000652:urine*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004611:Ellipticines / Q000493:pharmacokinetics / Q000652:urine*; D005978:Glutathione / Q000031:analogs & derivatives / Q000378:metabolism / Q000652:urine*; D006801:Humans; D008297:Male; D013058:Mass Spectrometry
D000470:Alkaloids; D004611:Ellipticines; C027767:elliptinium; D005978:Glutathione