[Study of the interaction between the organophosphorus insecticide GA-41 and model membranes using NMR-spectroscopy].
Interaction between organophosphorous insecticide GA-41 and liposomes formed from lecithin and multilamellar dispersion from lecithin and cardiolipin mixture (molar ratio is 7:3) has been studied by 1H- and 31P-NMR spectroscopy. The results obtained showed that while interacting with model membranes the GA-41 molecules intercalate into the range of hydrocarbon chains of phospholipids. At certain concentration of GA-41 its molecules induce the formation of some defects on bilayer structure, leading to permeability for Pr3+ ions.
Abdrashitova
I I
II
Aripov
T F
TF
Kamaev
F G
FG
Salakhutdinov
B A
BA
Abduvakhabov
A A
AA
D007306:Insecticides / Q000032:analysis*; D008081:Liposomes / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D009946:Organothiophosphorus Compounds / Q000032:analysis*; D010713:Phosphatidylcholines / Q000032:analysis
D007306:Insecticides; D008081:Liposomes; D009946:Organothiophosphorus Compounds; D010713:Phosphatidylcholines; C053779:S-butyl O-(1-methylethyl) methyl thiophosphonate
Izuchenie vzaimodeĭstviia fosfororganicheskogo insektitsida GA-41 s model'nymi membranami metodom IaMR-spektroskopii.