title: [Comparative study of the RNA-polymerase activity of non-pathogenic and pathogenic influenza viruses A and B].
abstract: Activity of RNA polymerase was studied in original non-pathogenic for mice viruses of influenza A and B (A/seal/Massachusetts 1/80, A/USSR 05/81, A/Philippines 2/82 and B/Singapore 227/79) and of their pathogenic derivatives. All the non-pathogenic viruses studied exhibited the low rate of transcriptase activity. Pathogenic derivatives of these strains exhibited higher activity of RNA polymerase, which was 1.5-3-fold higher as compared with the original strain. During passage of influenza viruses A and B in mice organism selection of the population appears to occur, which had the highest transcriptase activity.
authors: N F
authors: NF
authors: Pravdina
authors: R Ia
authors: RIa
authors: Podcherniaeva
authors: V V
authors: VV
authors: Skovorodka
authors: G A
authors: GA
authors: Galegov
authors: V M
authors: VM
authors: Zhdanov
mesh_terms: D000818:Animals; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D009980:Influenza A virus / Q000201:enzymology* / Q000472:pathogenicity; D009981:Influenza B virus / Q000201:enzymology* / Q000472:pathogenicity; D007700:Kinetics; D051379:Mice; D014771:Virion / Q000201:enzymology
chemical_list: D012321:DNA-Directed RNA Polymerases
vernacular_title: Sravnitel'noe issledovanie aktivnosti RNK-polimerazy u nepatogennykh i patogennykh virusov grippa A i B.