title: The veno-occlusive mechanism of the canine corpus cavernosum: angiographic and pharmacologic studies.
abstract: Studies were designed to document the normal angiography and pressure-volume characteristics of the canine corpus cavernosum, evaluate the effects of various vasoactive agents, and characterize a veno-occlusive mechanism. In fourteen dogs, baseline cavernosography demonstrated venous drainage via six to ten tributaries arising from the crura and entering the deep penile veins. Control cavernosometry during infusion of saline at 0.33 ml./sec. led to a rise in intracavernosal pressure (ICP) from 24.9 +/- 7.9 mm. Hg to 68.4 +/- 21.1 mm. Hg. Intracavernosal injection of a number of vasodilators, including papaverine, nitroglycerin, acetylcholine, and prostaglandin E2, raised baseline ICP significantly, caused extreme elevation of pressure during saline infusion (greater than 450 mm. Hg), and narrowed or obliterated the venous lumena at the site of tunica perforation, as judged angiographically. These effects could be reversed with phenoxybenzamine or norepinephrine. Our results further support the current understanding of the canine veno-occlusive mechanism.
authors: Department of Radiology, University of California, San Diego 92103.
authors: K
authors: K
authors: Valji
authors: J J
authors: JJ
authors: Bookstein
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D004285:Dogs; D004338:Drug Combinations; D007267:Injections / Q000379:methods; D008297:Male; D010410:Penile Erection / Q000187:drug effects; D010413:Penis / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000187:drug effects; D011859:Radiography; D014665:Vasodilator Agents / Q000494:pharmacology; D014680:Veins; D014690:Venous Pressure / Q000187:drug effects
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D014665:Vasodilator Agents; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; C027278:urovision