title: Primary ciliary dyskinesia and nasal mucociliary clearance.
abstract: In this study, nasal mucociliary clearance is investigated in patients with primary ciliary dyskinesia, patients with other respiratory tract infections and healthy persons. Mucociliary clearance is established with a drop of albumen labelled with 99m-Tc. From this study it appears that measurement of mucociliary clearance in the nose can serve as a reliable screening method. If a patient with respiratory tract infections shows a normal mucociliary clearance rate there is no primary ciliary dyskinesia, and a biopsy of ciliated epithelium is not necessary. If, after repeated examinations, a normal clearance rate cannot be demonstrated, a biopsy of ciliated epithelium should be taken for studying ciliary activity and ciliary ultrastructure.
authors: Department of Otorhinolaryngology, Free University Hospital, Amsterdam, The Netherlands.
authors: S
authors: S
authors: van der Baan
authors: A J
authors: AJ
authors: Veerman
authors: G A
authors: GA
authors: Heidendahl
authors: W
authors: W
authors: den Hollander
authors: L
authors: L
authors: Feenstra
mesh_terms: D002923:Cilia; D002925:Ciliary Motility Disorders / Q000175:diagnosis*; D006801:Humans; D009297:Nasal Mucosa; D012141:Respiratory Tract Infections / Q000503:physiopathology; D013668:Technetium Tc 99m Aggregated Albumin
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin