[The effect of intrahepatic cholestasis in pregnancy on various forms of cytochrome P-450-dependent biotransformation reactions].
The elimination of caffeine from plasma and the excretion of the main metabolites of metamizol (noramidopyrinemethanesulphonate sodium) into the urine were determined in healthy pregnant women (weeks 30-38 of pregnancy) and in patients with intrahepatic cholestasis in pregnancy (weeks 28-39 of pregnancy). From the elimination velocity of these model substances conclusions concerning the activity of 3-methylcholanthrene (caffeine elimination) and phenobarbital inducible isoenzymes (metamizol elimination) of cytochrome P-450 are drawn. Patients with intrahepatic cholestasis in pregnancy (t1/2 = 15.8 +/- 1.8 h) eliminate caffeine more slowly than healthy pregnant women (t1/2 = 11.0 +/- 0.8 h) at this stage of pregnancy. The excretion of the metabolites of metamizol is only in tendency diminished in patients with intrahepatic cholestasis. The influence of the intrahepatic cholestasis on the cytochrome P-450 isoenzymes investigated differs in degree.
Ortweiler
W
W
Institut für Pharmakologie und Toxikologie, Friedrich Schiller-Universität Jena.
Peiker
G
G
Siegert
C
C
Splinter
F K
FK
Traeger
A
A
D001711:Biotransformation; D002110:Caffeine / Q000378:metabolism; D002780:Cholestasis, Intrahepatic / Q000201:enzymology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D007700:Kinetics; D010634:Phenobarbital / Q000494:pharmacology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000201:enzymology*
D007527:Isoenzymes; D002110:Caffeine; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital
Der Einfluss der intrahepatischen Schwangerschaftscholestase auf verschiedene Cytochrom P-450-abhängige Biotransformations-reaktionen.