[Lipid composition of thrombocytes in diabetes mellitus depending on the degree of microangiopathy].
The paper is concerned with the results of a study of the content of platelet lipid fractions in 115 patients with type I and II diabetes mellitus with a different degree of vascular complications. The results showed that the development of vascular lesions caused the appearance of specific disorders of platelet lipid composition characteristic for type I and II diabetes mellitus. In type I disorders of neutral phospholipids and free fatty acids were noted whereas in type II the above changes were noted in parallel with changes in the levels of cholesterol and acid phospholipids. With an increase in vascular lesions in type II there was a significant increase in phospholipase A2 activity, in type I under the same conditions the activity of this enzyme was absent. These facts suggest correlation between the development of vascular complications of diabetes mellitus and disorders in platelet membrane lipid structure.
Kasimova
G M
GM
Mirtalipov
D T
DT
Abidov
A A
AA
Akbarov
V Z
VZ
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood* / Q000209:etiology; D006801:Humans; D008055:Lipids / Q000097:blood*; D008875:Middle Aged
D008055:Lipids
Lipidnyĭ sostav trombotsitov pri sakharnom diabete v zavisimosti ot stepeni mikroangiopatii.