[Tissue concentration of (2"R)-4'-O-tetrahydropyranyladriamycin in renal cell carcinoma and urinary bladder tumor (second report)].
Twenty milligrams of (2"R)-4'-O-tetrahydropyranyladriamycin (THP) was administered intravenously to 14 patients with renal cell carcinoma and 11 with urinary bladder tumor at the start of surgery. Heparinized peripheral blood samples were collected at regular intervals and separated into plasma and blood cell fractions by centrifugation for the estimation of the THP concentration. The THP concentrations in the surgical specimens were also studied. In the tissue of renal cell carcinoma, the nuclear fraction was obtained by fractionation in order to estimate the THP concentration. The THP concentrations of the plasma and blood cell fractions in both renal cell carcinoma and urinary bladder tumor gradually decreased with the lapse of time after administration. In renal cell carcinoma, grade 3 tumors revealed lower tissue and nuclear concentrations of THP than those of grade 1 and 2 tumors. Likewise, the tissue and nuclear concentrations of high-stage tumors were lower than those of low-stage tumors. On the other hand, in urinary bladder tumors, the THP concentrations in the tumors were found to be higher than those in normal urinary mucosa and muscle.
Masuda
H
H
Dept. of Urology, Hamamatsu University School of Medicine.
Hirose
J
J
Ohtawara
Y
Y
Suzuki
K
K
Tajima
A
A
Aso
Y
Y
Hiramatsu
K
K
Shomura
T
T
D002292:Carcinoma, Renal Cell / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006801:Humans; D007262:Infusions, Intravenous; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery
D004317:Doxorubicin; C027260:pirarubicin