[Effect of 1,2-dimethylhydrazine on the level of specific binding and ligand affinity to the estradiol receptor in the cytosol of uterine tissue in CBA mice].
1,2-dimethylhydrazine (DMH) inducing uterine sarcomas in CBA mice was studied for its prolonged effect on the level of specific binding and affinity to the estradiol receptors in cytosol fraction of CBA mice uterine tissue. It is shown that the dissociation constant 3H-estradiol-17 beta with a receptor protein in the cytosol of uterine tissue of DMH treated mice was slightly higher than in control mice. The theoretical number of the ligand binding sites with receptor protein and the level of free binding sites of estrogen receptors were higher in DMH-treated animals than in control mice during the whole period of observation.
Morozova
O V
OV
Kushlinskiĭ
N E
NE
D019813:1,2-Dimethylhydrazine; D000818:Animals; D002273:Carcinogens; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D004127:Dimethylhydrazines / Q000494:pharmacology*; D005260:Female; D008763:Methylhydrazines / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D011959:Receptors, Estradiol / Q000187:drug effects / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D002273:Carcinogens; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D019813:1,2-Dimethylhydrazine
Vliianie 1,2-dimetilgidrazina na uroven' spetsificheskogo sviazyvaniia i srodstvo liganda k retseptoru éstradiola v tsitozole tkaneĭ matki mysheĭ linii CBA.