title: [The effect of 30% N2O on the general hemodynamics of patients with heart valve lesions].
abstract: The effect of 50% N2O on the general haemodynamics of patients with heart valve lesions was evaluated. The addition of N2O to oxygen before cardiopulmonary bypass was associated with a decrease in the cardiac output from 3.60 +/- 0.23 to 3.04 +/- 0.17 l.min-1/m2 (P less than 0.001) although the filling pressure of the left ventricle remained constant and right ventricle preload was increased from 8.18 +/- 0.99 to 9.85 +/- 1.14 mmHg (P less than 0.05). Because the systemic blood pressure fell after N2O was added, the decrease in cardiac output is interpreted as representing a decrease in myocardial contractility. The changes in the inverse relationship between arterial blood pressure and stroke volume also support the concept that N2O suppresses myocardial contractility.
authors: Departement Anestesiologie, Universiteit van Stellenbosch, Parowvallei, KP.
authors: A
authors: A
authors: Coetzee
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006349:Heart Valve Diseases / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide / Q000494:pharmacology*; D013318:Stroke Volume / Q000187:drug effects; D014690:Venous Pressure / Q000187:drug effects
chemical_list: D009609:Nitrous Oxide
vernacular_title: Die effek van 50% N2O op die algemene hemodinamika van pasiënte met hartklepletsels.