title: Blood flow, vascular resistance and oxygen availability in malignant tumours upon intravenous flunarizine.
abstract: Tumour blood flow, an important determinant of the efficacy of presently available nonsurgical cancer treatments, significantly increased following a single I.V. injection of the calcium antagonist flunarizine. At a dose of 1 mg/kg, tumour blood flow increased approximately by 28% without a significant change in mean arterial blood pressure. The flow increase was paralleled by a similar improvement of the O2 availability to the cancer cells. The data suggest that flunarizine may provide a means of improving delivery of antineoplastic agents to tumours. Furthermore, flunarizine may also enhance the effectiveness of irradiation by increasing tumour oxygenation.
authors: Department of Applied Physiology, University of Mainz, F.R.G.
authors: P
authors: P
authors: Vaupel
authors: H
authors: H
authors: Menke
mesh_terms: D000818:Animals; D005260:Female; D005444:Flunarizine / Q000494:pharmacology; D008297:Male; D009374:Neoplasms, Experimental / Q000098:blood supply* / Q000378:metabolism / Q000503:physiopathology; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance
chemical_list: D005444:Flunarizine