[Normalizing effect of GABA derivatives on late behavioral disorders occurring in rats with early postnatal suppression of protein synthesis].
Changes in the central nervous system activity caused by an early postnatal (7th day of life) injection of cycloheximide (CHX) were studied during experiments on adult rats. Disturbances in the process of learning in the experiments on conditioned reflexes of active and passive avoidance, difficulties in solving the extrapolatory task, weakening of habituation, motor hyperactivity, disorder of movement coordination were noted. Electrophysiological analysis by means of evoked potential recovery cycles revealed deficiency of GABAergic inhibition in the cerebral cortex. Hydroxybutyric salts of sodium and lithium as well as piracetam injected after CHX (from 8th through 14th days of life) normalized general behavior and learning capability of adult rats. Phenibut (beta-phenyl-GABA) was inferior by its efficacy, GABA exhibited no distinct effect.
Burov
Iu V
IuV
Ostrovskaia
R U
RU
Smol'nikova
N M
NM
Trofimov
S S
SS
Savchenko
N M
NM
D000375:Aging / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects; D003513:Cycloheximide / Q000494:pharmacology; D004347:Drug Interactions; D004924:Escape Reaction / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D011506:Proteins / Q000037:antagonists & inhibitors*; D051381:Rats; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D011506:Proteins; D005680:gamma-Aminobutyric Acid; D003513:Cycloheximide
Normalizuiushchee vliianie proizvodnykh GAMK na otdalennye narusheniia povedeniia, voznikaiushchie u krys pri rannem postnatalnom ugnetenii belkovogo sinteza.