Restoration of analgesic response of C57BL/6J-bgJ (beige-J) mice to morphine by carbachol.
C57BL/6J-bgJ (beige-J) mice respond poorly to the analgesic effects of centrally administered (intracerebroventricular; i.c.v.) morphine in the tail-flick test. In the present study C57BL/6J-bgJ mice, their littermate (heterozygous) controls, and normal Swiss mice were given carbachol (200 micrograms/ml) in their drinking water for three weeks. Carbachol had no effect on control animals. However, the carbachol-treated beige-J mice responded to i.c.v.-administered morphine (1 microgram) significantly better than untreated beige-J mice and nearly as well as the normal mice.
Raffa
R B
RB
Department of Biological Research, Janssen Research Foundation, Spring House, PA 19477-0776.
Mathiasen
J R
JR
Vaught
J L
JL
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008816:Mice, Jimpy; D009020:Morphine / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000502:physiology
D011950:Receptors, Cholinergic; D009020:Morphine; D002217:Carbachol