The analysis of a titration study.
For analysis of data from a titration study, this paper adopts the idea of a life table analysis and utilizes a logistic linear dose-response model. The procedure uses iterated reweighted least-squares to provide parameter estimates. Computation of the asymptotic covariance of the life-table estimates of the response rates involves Greenwood's formula and a conditioning argument. A special case consists of examination of the covariance structure when no dropouts took place. Data from a titration study that investigated the efficacy of an anti-hypertensive compound illustrate the procedure.
Chuang
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Biostatistics Unit, Upjohn Company, Kalamazoo, MI 49001.
D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004341:Drug Evaluation / Q000379:methods*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy
D000959:Antihypertensive Agents