Hypersomnolence with beta-adrenergic blockers.
An elderly, mildly demented, hypertensive male patient developed hypersomnolence on administration of propranolol for treatment of hypertension; no other cause for hypersomnolence was detected. Upon replacement of propranolol with atenolol, he felt better but continued to be quite somnolent. When atenolol was discontinued, he reported to have lack of sleep. On readministration of subtherapeutic doses of the same beta-adrenergic blocking agents, he once again experienced excessive sleepiness. By discontinuing beta-blocking agents and introducing captopril, he felt much better, became pleasant and talkative, and blood pressure was well controlled. Beta antagonists are important drugs in the management of many cardiovascular problems. Propranolol, a lipophilic beta-blocking agent, and atenolol, a hydrophilic beta-blocking agent, are two of the major agents currently used clinically in the United States. Numerous neuropsychiatric side-effects of the beta-adrenergic blocking drugs have been reported, but hypersomnolence is not readily recognized as one of them.
Thachil
J
J
Hypertension Section, Zablocki Veterans Administration Medical Center, Milwaukee 53295.
Zeller
J R
JR
Kochar
M S
MS
D000368:Aged; D001262:Atenolol / Q000009:adverse effects*; D006970:Disorders of Excessive Somnolence / Q000139:chemically induced*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D011433:Propranolol / Q000009:adverse effects*; D012893:Sleep Wake Disorders / Q000139:chemically induced*
D001262:Atenolol; D011433:Propranolol