[Significance of clinically used gnotobiotechnics in the prophylaxis and during therapy of granulocytopenic infections].
Besides a literature survey own results by using the method of selective decontamination in the induction attendance of patients suffering from acute leucaemia are represented. These patients had an extreme infection disposition. The infection rate, the fever days, and the amount of systemic prescribed antibiotics could be decreased statistically significant. The results of selective decontamination, of granulocytes transfusion, and of isolation of patients in the life island achieved in our clinic are confronted. The selective decontamination is of central importance for prophylaxis in the same way as in the attendance of hospital infected defense diminished patients. Additionally, in the case of infections combinations of bactericidic antibiotics are indicated. On the other hand, granulocytes transfusion are not necessary. The effectivity of selective decontamination of the gastrointestinal tract underlines the significance of gnotobiotic methods within clinical practice.
Günther
I
I
Klinik für Innere Medizin des Bereiches, Wilhelm-Pieck-Universität Rostock, DDR.
Bohnenstengel
C M
CM
Brijmohan-Günther
R
R
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D002177:Candidiasis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D005260:Female; D005856:Germ-Free Life; D006098:Granulocytes / Q000637:transplantation*; D006801:Humans; D007938:Leukemia / Q000503:physiopathology*; D007970:Leukopenia / Q000628:therapy*; D008297:Male; D008875:Middle Aged
D000900:Anti-Bacterial Agents
Stellenwert klinisch angewandter Gnotobiotechnik zur Prophylaxe und während der Therapie granulocytopenischer Infektionen.