Ethanol prevents stress-induced increase in cortical DOPAC: reversal by RO 15-4513.
Electric foot-shock increased DOPAC and decreased DA levels by about 70 and 20% respectively in the medial prefrontal cortex in rats. Pretreatment with diazepam (5 mg/kg IP) or ethanol (1.2 g/kg orally) prevented these stress-induced changes. The protective effect of diazepam and ethanol was eliminated by RO 15-4513 (5 mg/kg IP) a partial inverse benzodiazepine agonist.
Fadda
F
F
Institute of Physiology, University of Cagliari, Italy.
Mosca
E
E
Niffoi
T
T
Colombo
G
G
Gessa
G L
GL
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D000818:Animals; D001386:Azides / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D004597:Electroshock; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D010648:Phenylacetates / Q000378:metabolism*; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*
D001386:Azides; D010648:Phenylacetates; D015102:3,4-Dihydroxyphenylacetic Acid; D001569:Benzodiazepines; D000431:Ethanol; C042957:Ro 15-4513; D003975:Diazepam