title: Intestinal iron absorption and mucosal transferrin in rats subjected to hypoxia.
abstract: Three days hypoxia (0.5 atm) increased the haemoglobin and haematocrit values in rats paralleled by enhanced intestinal iron absorption. The destination of recently-absorbed iron was primarily the erythropoietic system, viz. bone marrow, spleen and red cells. Total plasma transferrin, was increased by 30%, but no significant changes in mucosal transferrin were found. No increase in labelling of mucosal transferrin by absorbed iron was observed. These results suggest that mucosal transferrin does not play a major role in the regulation of intestinal iron absorption in hypoxia.
authors: Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middlesex, UK.
authors: K R
authors: KR
authors: Osterloh
authors: R J
authors: RJ
authors: Simpson
authors: S
authors: S
authors: Snape
authors: T J
authors: TJ
authors: Peters
mesh_terms: D000818:Animals; D002845:Chromatography; D004920:Erythropoiesis; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D007501:Iron / Q000378:metabolism / Q000493:pharmacokinetics*; D008102:Liver Circulation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000098:blood supply; D014168:Transferrin / Q000378:metabolism*
chemical_list: D014168:Transferrin; D007501:Iron