title: New antiamebic acridines. II. Synthesis and DNA binding of a series of 9-acridanones and 9-iminoacridines.
abstract: A series of novel 9-acridanones and 9-iminoacridines has been prepared and investigated by a number of spectroscopic techniques in order to determine the nature and extent of the binding of these compounds to DNA. Results are discussed with reference to antiamebic activity in vitro.
authors: Department of Pharmacy, University of Manchester, UK.
authors: D
authors: D
authors: Sharples
authors: J
authors: J
authors: Barbe
authors: A M
authors: AM
authors: Galy
authors: J P
authors: JP
authors: Galy
mesh_terms: D000166:Acridines / Q000138:chemical synthesis; D000563:Amebicides; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA; D009253:Naegleria / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000166:Acridines; D000563:Amebicides; D004247:DNA