Role of milk-derived IgG in passive maternal protection of neonatal ferrets against influenza.
Neonatal ferrets are protected against infection with influenza virus by colostral and milk-derived anti-influenza virus IgG after suckling on an immune mother. The levels of IgG elicited and then transmitted to neonates were similar when mothers were immunized by either live infection or killed vaccines. Maternal anti-influenza virus IgA and IgM appears not to cross the neonatal gut epithelium although both are present in maternal serum and milk.
Sweet
C
C
Department of Microbiology, South West Campus, University of Birmingham, U.K.
Jakeman
K J
KJ
Smith
H
H
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology; D002335:Carnivora / Q000276:immunology*; D005260:Female; D005289:Ferrets / Q000276:immunology*; D007114:Immunization; D007116:Immunization, Passive; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008431:Maternal-Fetal Exchange; D008892:Milk / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000517:prevention & control; D011247:Pregnancy
D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M