title: Lipid peroxidation and vitamin E levels during pregnancy in rats.
abstract: The present study examined pregnancy-related changes in the level of lipoperoxides and antioxidative substances such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px) and vitamin E in the maternal and fetal serum, liver, lungs, and placenta using Wistar rats. Pregnant rats fed a standard diet (control animals) showed an increase of lipoperoxides in the blood to a level 3 times greater than the non-pregnant level. When the rats were fed a vitamin E-deficient diet, lipoperoxides were produced in much greater amounts. Fetal blood also contained greater concentrations of lipoperoxides by the use of a vitamin E-deficient diet. However, liver and lung tissues contained lipoperoxides in essentially constant concentrations throughout non-pregnancy and pregnancy. Fetal liver and lung tissues showed higher concentrations than the maternal concentrations. Fetal blood and tissue concentrations of vitamin E reflected the maternal concentrations, and the values in vitamin E-deficient animals were as small as 0.1-0.2 of the values in normally fed animals. As a protective factor against lipid peroxidation, SOD was slightly increased in the liver tissues of pregnant control animals, but catalase and GSH-Px were significantly decreased in the organ. A similar tendency was observed in vitamin E-deficient animals.
authors: Division of Obstetrics and Gynecology, Center for Adult Diseases, Kurashiki, Japan.
authors: T
authors: T
authors: Yoshioka
authors: H
authors: H
authors: Motoyama
authors: F
authors: F
authors: Yamasaki
authors: M
authors: M
authors: Ando
authors: Y
authors: Y
authors: Takehara
authors: M
authors: M
authors: Yamasaki
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005333:Fetus / Q000201:enzymology / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008168:Lung / Q000201:enzymology / Q000378:metabolism; D010920:Placenta / Q000201:enzymology / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism; D014018:Tissue Distribution; D014810:Vitamin E / Q000097:blood / Q000378:metabolism*; D014811:Vitamin E Deficiency / Q000201:enzymology / Q000378:metabolism
chemical_list: D008054:Lipid Peroxides; D014810:Vitamin E; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase