Long-term study of the immuno-pathological consequences of sympathetic orchiopathia in the rat.
Unilateral testicular ischaemia was induced in Wistar rats by ligation and division of the testicular and deferential vessels. Damage (as assessed by a Johnsen count) to the contralateral testis caused significant spermatogenic suppression only at the equator of the testis at 28 days after operation. Cytotoxic antisperm antibody production increased progressively from 7 to 14 days and became maximal at 28 days after infarction, but after 3 and 6 months antibody production was decreasing. The presence of agglutinating antisperm antibody was noted at 28 days, 3 months and 6 months after infarction. Serum immunoglobulin estimations revealed an increase in IgG and IgM levels at 7 days and IgM levels at 14 days, supporting the contention that an immunological reaction had occurred. It is suggested that unilateral testicular ischaemia in the rat, an animal model intended to mimic torsion of the testis in the human, causes a transient immunological phenomenon (sympathetic orchiopathia) which recovers over the course of time. Caution should be exercised before regarding this relatively common surgical emergency as an aetiology of oligospermia or asthenospermia.
Lewis-Jones
D I
DI
Department of Human Anatomy and Cell Biology, University of Liverpool, U.K.
Lynch
R V
RV
Kerrigan
D D
DD
Davies
I
I
D000372:Agglutination Tests; D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D007136:Immunoglobulins / Q000032:analysis; D007511:Ischemia / Q000276:immunology / Q000473:pathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013091:Spermatogenesis; D013094:Spermatozoa / Q000276:immunology; D013737:Testis / Q000098:blood supply* / Q000276:immunology / Q000473:pathology; D013997:Time Factors
D007136:Immunoglobulins