Influence of gender on the disposition of cefotaxime and desacetylcefotaxime.
The pharmacokinetics of cefotaxime and desacetylcefotaxime were evaluated in 11 female and 13 male subjects with end-stage renal disease. Subjects received single 1- or 2-g intravenous doses of cefotaxime sodium. Serum, urine, and dialysate concentrations of cefotaxime and desacetylcefotaxime were determined using high performance liquid chromatography. The results indicate that gender has no clinically significant influence on the disposition of cefotaxime or its active metabolite desacetylcefotaxime.
Guay
D R
DR
Drug Evaluation Unit, Hennepin County Medical Center, Minneapolis, Minnesota 55415.
Matzke
G R
GR
Heim
K L
KL
Halstenson
C E
CE
Abraham
P A
PA
Keane
W F
WF
D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism; D008297:Male; D012737:Sex Factors
C029281:desacetylcefotaxime; D002439:Cefotaxime