title: Lipid oxidation in plasma and tissues from estrogenized chicken hens.
abstract: Four groups of 5-month-old chicken hens were given estradiol treatments and/or 5% dietary oil supplement for 14 days, after which blood plasma, liver, heart, and skeletal muscle were analyzed for lipid oxidation by TBA assay for malonaldehyde. Plasma from estradiol-treated birds had 8-fold higher levels of malonaldehyde compared to untreated birds. The bulk of this effect was due to a 5-fold increase in plasma lipid, but this lipid also contained a 70% higher concentration of malonaldehyde. Estradiol treatments produced significantly increased TBA numbers in liver, heart, and skeletal muscle. Corn oil supplementation significantly increased the malonaldehyde concentration in fat extracted from liver and heart, but not from plasma or skeletal muscle. It was concluded that estradiol treatment, in addition to generally increasing the deposition of fat in plasma and organs, also enhanced the concentration of malonaldehyde equivalents in plasma and organ fat.
authors: Harlan E. Moore Heart Research Foundation, Champaign, Illinois 61820.
authors: D E
authors: DE
authors: Leszczynski
authors: J
authors: J
authors: Pikul
authors: F A
authors: FA
authors: Kummerow
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000097:blood; D002645:Chickens; D003314:Corn Oil / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction
chemical_list: D004967:Estrogens; D008315:Malondialdehyde; D003314:Corn Oil