title: The effect of hypermagnesaemia on serum immunoreactive calcitonin levels in normal human subjects.
abstract: The effect of hypermagnesaemia on serum levels of immunoreactive calcitonin was studied in normal human subjects. After iv administration of magnesium sulphate over 120 min, the mean (+/- SEM) serum magnesium concentration rose from the baseline level of 0.9 +/- 0.1 to 2.6 +/- 0.3 mmol/l (P less than 0.01), and thereafter remained higher than the baseline level. The magnesium infusion caused a significant increase in serum immunoreactive calcitonin levels (P less than 0.01). The rise in serum magnesium concentration was accompanied by a significant decrease in the concentrations of corrected serum calcium and whole blood ionized calcium (P less than 0.01, P less than 0.01 respectively). Our results suggest that hypermagnesaemia causes an increase in serum immunoreactive calcitonin levels in normal human subjects despite a decrease in the concentrations of corrected serum calcium and whole blood ionized calcium.
authors: Second Department of Internal Medicine, Osaka University Medical School, Japan.
authors: K
authors: K
authors: Suzuki
authors: N
authors: N
authors: Kono
authors: T
authors: T
authors: Onishi
authors: S
authors: S
authors: Tarui
mesh_terms: D000328:Adult; D002116:Calcitonin / Q000097:blood*; D002118:Calcium / Q000097:blood; D006801:Humans; D007262:Infusions, Intravenous; D008274:Magnesium / Q000097:blood*; D008278:Magnesium Sulfate / Q000008:administration & dosage; D008297:Male
chemical_list: D008278:Magnesium Sulfate; D002116:Calcitonin; D008274:Magnesium; D002118:Calcium