Selective catalysis of A.T base pair proton exchange in DNA complexes: imino proton NMR analysis.
Polyaromatic molecules with amino chain substituents, upon binding with DNA, selectively catalyze exchange of the A.T base pair protons with bulk water protons. The amine-catalyzed exchange is mediated by compounds which are A.T and G.C base sequence specific, intercalators, and outside binders. A mechanism for the selective exchange, involving transient opening and closing of individual A.T base pairs in the duplex, is discussed.
Strekowski
L
L
Department of Chemistry, Georgia State University, Atlanta 30303.
Watson
R A
RA
Wilson
W D
WD
D000225:Adenine; D001482:Base Composition; D004247:DNA; D007097:Imines; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009690:Nucleic Acid Conformation; D013941:Thymine
D007097:Imines; D004247:DNA; D000225:Adenine; D013941:Thymine