title: Vasopressin increases 45Ca2+ influx in rat aortic smooth muscle cells.
abstract: [Arg8]Vasopressin (AVP)-induced 45Ca2+ influx was examined in vascular smooth muscle cells derived from rat aorta. AVP stimulated the 45Ca2+ influx in a concentration-dependent manner. The effect was abolished in the presence of La3+. The dihydropyridine calcium channel antagonist darodipine did not affect the AVP-induced influx of 45Ca2+. These data suggest that AVP stimulates in these cultured aortic smooth muscle cells a receptor-operated channel (ROC) that is permeable to Ca2+.
authors: Preclinical Research, Sandoz Ltd., Basel, Switzerland.
authors: A
authors: A
authors: Wallnöfer
authors: C
authors: C
authors: Cauvin
authors: U T
authors: UT
authors: Rüegg
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D001127:Arginine Vasopressin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002478:Cells, Cultured; D007700:Kinetics; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011921:Rats, Inbred WKY
chemical_list: D002121:Calcium Channel Blockers; D001127:Arginine Vasopressin; D002118:Calcium