Rapidly progressive glomerulonephritis associated with rifampicin therapy for pulmonary tuberculosis.
Two months after commencing continuous treatment with rifampicin, isoniazid, streptomycin and pyrazinamide for pulmonary tuberculosis a patient developed a nephrotic syndrome, acute nonoliguric renal failure and evidence of intravascular hemolysis. Renal biopsy revealed a severe crescentic nephritis with mild interstitial changes. The use of rifampicin has been associated with various renal abnormalities and this report documents the occurrence of a rapidly progressive crescentic glomerulonephritis presenting as nephrotic syndrome in a patient receiving continuous treatment with rifampicin.
Murray
A N
AN
Department of Medicine, University of Cape Town, South Africa.
Cassidy
M J
MJ
Templecamp
C
C
D000208:Acute Disease; D058186:Acute Kidney Injury / Q000139:chemically induced; D000328:Adult; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000139:chemically induced; D012293:Rifampin / Q000009:adverse effects*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D012293:Rifampin