Effects of corticosterone on neurones of the locus coeruleus, in the rat.
The effects of microelectrophoretic application of corticosterone (CS) on single neurones of the locus coeruleus (LC) were investigated in rats under urethane anaesthesia. Ejecting currents generally ranged from 10 to 60 nA. CS produced an excitatory effect in 73% of the neurones and no effect in 27%. The prevailingly excitatory effects induced by CS on LC neurones may be related to the regulation of those complex events, which constitute the 'stress response'.
Avanzino
G L
GL
Istituto di Fisiologia Umana, Università degli Studi, Genova, Italy.
Ermirio
R
R
Cogo
C E
CE
Ruggeri
P
P
Molinari
C
C
D000818:Animals; D003345:Corticosterone / Q000494:pharmacology*; D008125:Locus Coeruleus / Q000166:cytology / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D003345:Corticosterone