Caffeine-diazepam interaction and local cerebral glucose utilization in the conscious rat.
The quantitative 2-[14C]deoxyglucose autoradiographic method was used to study the effects of the acute administration of a sedative anticonvulsant dose of diazepam (2 mg/kg) on rat brain energy metabolism. This benzodiazepine was injected to rats chronically treated for two weeks either by caffeine (10 mg/kg/day) or by saline. After the administration of diazepam to saline-treated rats, average glucose utilization of the brain as a whole was reduced by 21% and rates of glucose utilization were deeply decreased in frontal and auditory cortex, mammillary body, lateral thalamus, medial and lateral geniculate. In caffeine-treated rats, the administration of diazepam induced the same effects of brain energy metabolism as in saline-treated rats. The results of the present study indicate that diazepam mainly decreases glucose utilization in structures widely believed to mediate anxiety.
Nehlig
A
A
INSERM U.272, Pathologie et Biologie du Développement Humain, Université de Nancy I, France.
Daval
J L
JL
Pereira de Vasconcelos
A
A
Boyet
S
S
D000818:Animals; D001345:Autoradiography; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002110:Caffeine / Q000378:metabolism / Q000494:pharmacology*; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism / Q000494:pharmacology*; D004734:Energy Metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003837:Deoxy Sugars; D002110:Caffeine; D003847:Deoxyglucose; D003975:Diazepam