Molecular cloning and sequencing of the F and 22K membrane protein genes of the RSS-2 strain of respiratory syncytial virus.
The nucleotide sequences of the adjacent genes coding for the F protein and 22K protein of the RSS-2 strain of human respiratory syncytial (RS) virus were determined from cDNA clones of genomic RNA. Comparison of these sequences and the inferred amino acid sequences of the F and 22K proteins with the corresponding published sequences of another subgroup A virus, the A2 strain of RS virus, reveals extensive overall homology (greater than 95%) at both the nucleotide and amino acid levels, even though these two viruses were isolated 15 years apart in different continents. The intergenic region and the hydrophobic amino-terminal signal sequence of the F proteins of the two viruses, however, are much less conserved.
Baybutt
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HN
Department of Biological Sciences, University of Warwick, Coventry, U.K.
Pringle
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CR
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D005814:Genes, Viral; D008565:Membrane Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D012136:Respiratory Syncytial Viruses / Q000235:genetics*; D014760:Viral Fusion Proteins / Q000235:genetics*; D014763:Viral Matrix Proteins / Q000235:genetics*
D004279:DNA, Viral; D008565:Membrane Proteins; D014760:Viral Fusion Proteins; D014763:Viral Matrix Proteins; D004247:DNA