Microencapsulation of potassium chloride with mastic.
The present investigation deals with the microencapsulation of potassium chloride with mastic. Spherical potassium chloride crystals with a mean particle diameter of approximately 450 microns were used. It could be shown that with a layer of mastic wall material thicker than 21 microns the release of potassium chloride in the in vitro test can be controlled for more than 6 h. The thickness of the wall material over the tested range of 21 to 33 microns has only a limited effect on the kinetics of release of potassium chloride. Increasing the thickness of the layer from 21 to 33 microns merely leads to a reduction of about another 10% in the amount of drug released in 6 h.
Georgarakis
M
M
Aristotelion University of Thessaloniki, Department of Pharmacy, Greece.
Gröning
R
R
Henzler
P
P
D002214:Capsules; D002626:Chemistry, Pharmaceutical; D000069997:Mastic Resin; D008855:Microscopy, Electron, Scanning; D010936:Plant Extracts; D011189:Potassium Chloride / Q000008:administration & dosage*; D012116:Resins, Plant
D002214:Capsules; D000069997:Mastic Resin; D010936:Plant Extracts; D012116:Resins, Plant; D011189:Potassium Chloride