title: Effects of cholinergic drugs on muscle contraction in Moniliformis moniliformis (Acanthocephala).
abstract: In whole Moniliformis moniliformis spontaneous muscle contractions were rhythmic; longitudinal contractions were measured with a force transducer. The cholinergic agonists levamisole and nicotine significantly increased muscle tension in whole worms; these contractions were tonic and were antagonised by the ganglionic blocker pentolinium and by piperazine. In addition, levamisole-induced contractions were inhibited by gallamine, hexamethonium, and norepinephrine. In worm segments, where drugs in solution were injected through the worms, acetylcholine (ACh) and nicotinic agonists were effective in causing contractions, whereas muscarinic agonists in concentrations up to 1 mM had no effect. Although muscle contraction in M. moniliformis was induced by nicotinic agonists, these contractions were effectively antagonised by a range of chemicals that block ganglionic, skeletal, and muscarinic sites in vertebrates. The presence of ACh in M. moniliformis and the effects of nicotinic agonists on muscle contraction suggest that ACh is a putative excitatory neurotransmitter.
authors: Department of Zoology, University of Toronto, Ontario, Canada.
authors: N C
authors: NC
authors: Sangster
authors: D F
authors: DF
authors: Mettrick
mesh_terms: D000049:Acanthocephala / Q000187:drug effects*; D000109:Acetylcholine / Q000032:analysis; D000110:Acetylcholinesterase / Q000032:analysis; D000818:Animals; D002091:Butyrylcholinesterase / Q000032:analysis; D002217:Carbachol / Q000494:pharmacology; D002794:Choline / Q000032:analysis; D005260:Female; D006373:Helminthiasis / Q000188:drug therapy; D007978:Levamisole / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008990:Moniliformis / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D009015:Morantel / Q000627:therapeutic use; D009119:Muscle Contraction / Q000187:drug effects; D009538:Nicotine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology*; D010277:Parasympathomimetics / Q000494:pharmacology*; D051381:Rats
chemical_list: D010276:Parasympatholytics; D010277:Parasympathomimetics; D007978:Levamisole; D009538:Nicotine; D009015:Morantel; D002217:Carbachol; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D002794:Choline; D000109:Acetylcholine