Tissue culture model of adenoma invasion.
Colon carcinoma cells cocultured with adenoma cells were examined under various experimental conditions. Carcinoma cells were shown to have a selective advantage over adenoma cells. This advantage is enhanced by exposure to a tumor promoter.
Friedman
E A
EA
Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
D000236:Adenoma / Q000201:enzymology / Q000473:pathology*; D001550:Benzamidines / Q000494:pharmacology; D002277:Carcinoma / Q000201:enzymology / Q000473:pathology*; D003110:Colonic Neoplasms / Q000201:enzymology / Q000473:pathology*; D046508:Culture Techniques; D006801:Humans; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
D001550:Benzamidines; D014568:Urokinase-Type Plasminogen Activator; C032157:benzamidine; D013755:Tetradecanoylphorbol Acetate