[Effect of cardioplegia on nitrogen and energy metabolism of the human heart].
The interrelation between the energy and nitrogenous metabolism of the myocardium during cardioplegia has been studied in patients with congenital valvular heart disease (tetralogy of Fallot--12 patients, ventricular septal defect--5 patients). Whole body hypothermia with repeated heart reperfusion with cold cardioplegic blood perfusate was used for the protection of the myocardium. However, ATP level of the myocardium of some patients decreased by 20% and more of the baseline. This loss was accompanied by a reduction in glutamate and aspartate levels and a rise in ammonium and alanine levels in the myocardium (by 17.7 +/- 3.8; 17.6 +/- 5.9; 61.4 +/- 12.5 and 92.4 +/- 26.3% of the baseline, respectively).
Pisarenko
O I
OI
Studneva
I M
IM
Portnoĭ
V F
VF
Arapov
A D
AD
Korostylev
A M
AM
D000255:Adenosine Triphosphate / Q000378:metabolism; D000409:Alanine / Q000378:metabolism; D000641:Ammonia / Q000378:metabolism; D001224:Aspartic Acid / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D006324:Heart Arrest, Induced; D006801:Humans; D009206:Myocardium / Q000378:metabolism*
D005971:Glutamates; D001224:Aspartic Acid; D000641:Ammonia; D000255:Adenosine Triphosphate; D000409:Alanine
Vliianie kardioplegii na azotistyĭ i énergeticheskiĭ obmen serdtsa cheloveka.