2-Pyrrolidinone in human cerebrospinal fluid: a major constituent of total gamma-aminobutyric acid.
2-Pyrrolidinone, the lactam of gamma-aminobutyric acid (GABA), is identified as the major constituent of total GABA in human CSF. Structural elucidation was done by mass spectrometry. In lumbar CSF of four patients, 2-pyrrolidinone represented about 54% of GABA found after acid hydrolysis, thus accounting for essentially all of the hitherto unknown GABA fraction in CSF.
Haegele
K D
KD
Merrell Dow Research Institute, Strasbourg, France.
Schwartz
J J
JJ
Schoun
J
J
Schmitt
A H
AH
Schechter
P J
PJ
D000328:Adult; D002336:Carnosine / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013058:Mass Spectrometry; D008875:Middle Aged; D011760:Pyrrolidinones / Q000134:cerebrospinal fluid*; D005680:gamma-Aminobutyric Acid / Q000134:cerebrospinal fluid*
D011760:Pyrrolidinones; C005038:homocarnosine; D005680:gamma-Aminobutyric Acid; D002336:Carnosine; C028537:2-pyrrolidone