[Ceftriaxone, a cephalosporin with high hepatic elimination. Evaluation of its biliary clearance in man. Therapeutic value].
The biliary elimination of ceftriaxone, a cephalosporin derivative, was quantitatively studied in man with the help of high pressure liquid chromatography (HPLC). In 6 healthy volunteers a mean peak concentration of 565 +/- 347 (SEM) micrograms/ml was observed in the aspirated duodenal fluid within the first hour after i.v. administration of 2 g ceftriaxone, and 1.4 +/- 0.5% of the dose was recovered during the 4 hours investigation period. In 10 cholecystectomized patients provided with a T-drain, the biliary concentration peak (1078 +/- 158 micrograms/ml) was reached within 1 hour after administration and the total 24 hours recovery amounted to 9.5 +/- 2.9% of the dose given. In 12 patients undergoing cholecystectomy, serum, and choledochal (CB) and gallbladder bile (GB) were peroperatively collected 1 hour after i.v. administration of 2 g ceftriaxone; the respective concentrations were: 199 +/- 10 (serum), 5259 +/- 1085 (CB), and 4533 +/- 809 (GB) micrograms/ml. These data point to excellent biliary elimination of ceftriaxone compared with the other beta-lactams previously studied, and afford evidence of its high therapeutic potential in biliary tract infections.
Brogard
J M
JM
Département de médecine interne, Centre hospitalo-universitaire, Strasbourg.
Jehl
F
F
Paris-Bockel
D
D
Sini
F
F
Blickle
J F
JF
Adloff
M
M
Monteil
H
H
D000368:Aged; D001646:Bile / Q000032:analysis; D002443:Ceftriaxone / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000493:pharmacokinetics; D004386:Duodenum / Q000378:metabolism; D005260:Female; D006801:Humans; D007419:Intestinal Secretions / Q000032:analysis; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D002511:Cephalosporins; D002443:Ceftriaxone
La ceftriaxone, céphalosporine à forte élimination hépatique. Evaluation de son passage biliaire chez l'homme. Intérêt thérapeutique.