Single- and combination-antibiotic therapy for experimental endocarditis caused by methicillin-resistant Staphylococcus aureus.
The efficacy of fosfomycin in combination with vancomycin or gentamicin was evaluated in experimental endocarditis caused by methicillin-resistant Staphylococcus aureus. After 5 days of therapy, both combinations proved to be highly effective since all rabbits had sterile vegetations.
Rodríguez
A
A
Instituto de Farmacología Española, Madrid, Spain.
Vicente
M V
MV
Olay
T
T
D000818:Animals; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D005578:Fosfomycin / Q000008:administration & dosage*; D005839:Gentamicins / Q000008:administration & dosage*; D008712:Methicillin; D010403:Penicillin Resistance; D011817:Rabbits; D013211:Staphylococcus aureus; D014640:Vancomycin / Q000008:administration & dosage*
D005839:Gentamicins; D005578:Fosfomycin; D014640:Vancomycin; D008712:Methicillin