Effects of sperm protamine on human cervical epithelial cells and BHK 21 cells in vitro.
The addition of protamine, of both human and animal origin, to cultures of epithelial and fibroblastic cells has demonstrated that this component of sperm proteins may be capable of bringing about neoplastic transformation in vitro.
French
P W
PW
Department of Obstetrics and Gynaecology, University of Sydney, Australia.
Coppleson
M
M
Reid
B L
BL
D000818:Animals; D002273:Carcinogens; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D002584:Cervix Uteri / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D006224:Cricetinae; D004591:Electrophoresis, Polyacrylamide Gel; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D011479:Protamines / Q000302:isolation & purification / Q000494:pharmacology*; D013094:Spermatozoa / Q000032:analysis; D013936:Thymidine / Q000378:metabolism
D002273:Carcinogens; D011479:Protamines; D013936:Thymidine