title: Genetic variation in mitochondrial DNA from some aboriginal Australians.
abstract: Mitochondrial (mt) DNAs from 17 aboriginal Australians, predominantly from the coastal region of the Northern Territory were isolated and digested with four four-base restriction endonucleases, two of which revealed variation between samples. The observed fragment patterns were used directly in parsimony analyses of phylogenetic relationships between the samples, and were also converted to estimates of the number of substitutions per nucleotide position between samples (delta), which estimates were then used in distance analyses of phylogeny. The inferred fragment patterns of the completely sequenced 'Cambridge' human mtDNA were also included in these analyses. No strong evidence of geographic variation was found, consistent with previous findings of Australian aborigines and other humans generally, although the most divergent sample was one of two from Sydney, indicating that further work is desirable. The estimate of mean difference between samples (diversity), 0.0017 +/- 0.0003 (mean +/- 95% confidence interval), is significantly lower than that reported previously for humans generally.
authors: School of Biochemistry, University of New South Wales, Kensington.
authors: G
authors: G
authors: Griziotis
authors: C
authors: C
authors: Hawkins
authors: A G
authors: AG
authors: Mackinlay
authors: R H
authors: RH
authors: Crozier
mesh_terms: D001315:Australia; D004272:DNA, Mitochondrial / Q000032:analysis / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D010920:Placenta / Q000032:analysis; D011247:Pregnancy
chemical_list: D004272:DNA, Mitochondrial