title: Failure of fasting and changes in plasma metabolites to affect spontaneous fluctuations in plasma concentrations of ovine placental lactogen.
abstract: The relationships between plasma concentrations of energy substrates and placental lactogen (PL) were investigated in pregnant ewes. In successive hourly samples of plasma PL, concentrations varied by +/- 30% but were not related to general activity or feeding of the ewes or the time of day. Fasting ewes for 72 h did not alter the pattern or the mean PL titres. Insulin-induced acute hypoglycaemia, hyperglycaemia and decreases or increases in free fatty acids (FFA) all failed to alter PL levels significantly during 5-h post-treatment periods. These experiments demonstrate that PL secretion in the ewe fluctuates markedly and is unaffected by changes in plasma glucose FFA concentrations.
authors: Department of Animal Science, Cornell University, Ithaca, New York 14853.
authors: W R
authors: WR
authors: Butler
authors: S E
authors: SE
authors: Huyler
authors: A S
authors: AS
authors: Grandis
authors: S
authors: S
authors: Handwerger
mesh_terms: D000085:Acetates / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005865:Gestational Age; D010928:Placental Lactogen / Q000097:blood*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D012756:Sheep / Q000502:physiology*
chemical_list: D000085:Acetates; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D010928:Placental Lactogen