Mutagenicity of actinomycin D in mammalian cells due to clastogenic effects.
Actinomycin D was clastogenic and mutagenic in L5178Y/TK +/- -3.7.2C mouse lymphoma cells. The majority of the mutants were small colonies, indicating that actinomycin D acts primarily by a clastogenic mechanism.
DeMarini
D M
DM
Genetic Toxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711.
Brock
K H
KH
Doerr
C L
CL
Moore
M M
MM
D000818:Animals; D002869:Chromosome Aberrations; D003609:Dactinomycin / Q000494:pharmacology*; D007939:Leukemia L1210; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics; D013937:Thymidine Kinase / Q000235:genetics; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014410:Tumor Stem Cell Assay
D009153:Mutagens; D009363:Neoplasm Proteins; D003609:Dactinomycin; D013937:Thymidine Kinase