Bactericidal and antineoplastic effect of combination of norfloxacin and adriamycin.
Norfloxacin and adriamycin were tested alone and in combination for bactericidal activity against different strains of gram-negative bacteria. The antitumoral effect of a combination of norfloxacin and adriamycin was determined in mice bearing Ehrlich ascites carcinoma and in mice bearing P 388 leukemia. No interference with the antibacterial activity of norfloxacin or with the antitumoral activity of adriamycin was observed.
Castelli
M
M
Department of Pharmacology, Chemotherapy and Toxicology, University of Milano, Italy.
Barbieri
M L
ML
Bertolini
A
A
Bossa
R
R
Galatulas
I
I
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D004317:Doxorubicin / Q000627:therapeutic use*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000627:therapeutic use*
D004317:Doxorubicin; D009643:Norfloxacin