[Preparations of acetylsalicylic acid sustained-release tablets on hydrophilic matrix forms].
The aim of this study was to prepare a tablet with acetylsalicylic acid based on hydrophilic matrix form by means of polyvinyl alcohol. The liberation was carried out with the column dissolution-rate method. In contrast to other studies, the percentage of the cumulative liberation is decreased by increasing the drug concentration. Acetylsalicylic acid caused a decrease of the wetting and the rate of swelling.
Süss
W
W
Pharmazeutisches Zentrum Oschatz, Klinikapotheke Hubertusburg, Wermsdorf.
Bruder
K
K
D001241:Aspirin / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D005079:Excipients; D011142:Polyvinyl Alcohol
D003692:Delayed-Action Preparations; D005079:Excipients; D011142:Polyvinyl Alcohol; D001241:Aspirin
Herstellung von Acetylsalicylsäuretabletten mit verzögerter Wirkstoffliberation auf der Basis hydrophiler Matrixformen.