Steroids and related products. LIV. The synthesis of 11-oxa steroids. VI. The synthesis of 11-oxatestosterone.
The synthesis of 11-oxatestosterone from 11-oxa-5 alpha-androstane-3,17-dione, which is available from hecogenin, is described. The product shows, in comparison with the natural hormone, diminished androgenic and anabolic activities.
Salvi
V S
VS
Department of Chemistry, Université Laval, Quebec, Canada.
Mukherjee
D
D
Engel
C R
CR
D045930:Anabolic Agents / Q000138:chemical synthesis; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D008722:Methods; D051381:Rats; D013260:Steroids, Heterocyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D013739:Testosterone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D045165:Testosterone Congeners / Q000138:chemical synthesis
D045930:Anabolic Agents; D013260:Steroids, Heterocyclic; D045165:Testosterone Congeners; C053253:11-oxatestosterone; D013739:Testosterone