title: Synthesis and antimycotic activity of some benzyloxyimino compounds.
abstract: Some benzyloxyimio compounds, related to oxiconazole and having a 1H-indole or 1H-benzimidazole moiety, have been synthesized and tested in vitro for their antimycotic activity against Candida tropicalis and C. albicans. The most active was showed to be 0-(2,4-dichlorobenzyl)-1-benzyl-5-nitro-1H-benzimidazole-2-carboxaldehyd e oxime (MIC: 25 micrograms/ml against both microorganisms). A structural feature important for the biological activity of the series appears to be presence of a benzimidazole nucleus substituted by an electron withdrawing group.
authors: Institute of Pharmaceutical Chemistry of the University, Bologna, Italy.
authors: L
authors: L
authors: Garuti
authors: G
authors: G
authors: Giovanninetti
authors: A
authors: A
authors: Ferranti
authors: A
authors: A
authors: Chiarini
authors: G
authors: G
authors: Bertocchi
authors: P
authors: P
authors: Sabatino
authors: P
authors: P
authors: Brigidi
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D001562:Benzimidazoles; D001593:Benzyl Compounds; D007211:Indoles