Effect of diet on oxidation of 17 beta-estradiol in vivo.
The effect of a high fat, low carbohydrate, low protein diet on the in vivo oxidation of 17 beta-estradiol was studied using radiometric methods. Five male chimpanzees were fed a normal (13%) fat diet or a high (65%) fat diet for 8 weeks. After a 4-week rest period, the animals were fed the alternative diet. The mean percent oxidation of 16 alpha-[3H]estradiol-17 beta 24 h after injection was 3.8 +/- 1.3% (+/- SD) on the normal diet vs. 18.4 +/- 4.7% on the high fat diet (P less than 0.01). In contrast, the mean percent oxidation of 2-[3H]estradiol 24 h after injection was 31.6 +/- 3.8% (+/- SD) on the normal diet vs. 20.0 +/- 3.5% on the high fat diet (P less than 0.05). These results suggest that the oxidation of 17 beta-estradiol to estriols relative to that to catechol estrogens is increased by a high fat diet.
Musey
P I
PI
Department of Biology, Atlanta University, Georgia 30314.
Collins
D C
DC
Bradlow
H L
HL
Gould
K G
KG
Preedy
J R
JR
D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D004958:Estradiol / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D002679:Pan troglodytes; D013997:Time Factors
D004041:Dietary Fats; D004958:Estradiol