title: [Problems of the relationship of the therapeutic effect and the concentration of drugs in the blood].
abstract: Certain approaches to analysis of the drug concentration-response relationship based on the mechanism of the effect realization and the results of their clinical trials are discussed. The studies are exemplified by a model for quantitative analysis of the concentration-response relationship developed for diuretics and by the results of the clinical trial of the principle of the maximum providing prediction of the steady-state level of the drugs in blood and estimation of the drug effect.
authors: M G
authors: MG
authors: Glezer
authors: S V
authors: SV
authors: Iakovlev
authors: L E
authors: LE
authors: Kholodov
mesh_terms: D000368:Aged; D004077:Digoxin / Q000097:blood / Q000627:therapeutic use*; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005665:Furosemide / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008433:Mathematics; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy; D013997:Time Factors
chemical_list: D004077:Digoxin; D005665:Furosemide
vernacular_title: Problemy sviazi terapevticheskogo éffekta i kontsentratsii lekarstvennykh veshchestv v krovi.