Could N-nitrosamino phosphates be transport forms of activated N-nitrosamines?
The stability of N-nitroso-N-methylamine-N-ethyl phosphate (NMEP) and N-nitroso-N-ethylamine-N-ethyl phosphate (NEEP) was studied in rat serum and in rat liver homogenate and found to be sufficiently high for the phosphates to be transported in vivo. In liver homogenates, the cleavage was more efficient, and a higher phosphatase activity was found in liver microsomal and cytosolic fractions than in serum. The substances exert a distinct activity in the Salmonella typhimurium mutagenicity test.
Frank
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N
Institute of Toxicology and Chemotherapy, German Cancer Research Center, Heidelberg.
Wiessler
M
M
Pool
B L
BL
Frei
E
E
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active; D003600:Cytosol / Q000201:enzymology; D008862:Microsomes, Liver / Q000201:enzymology; D009152:Mutagenicity Tests; D009602:Nitrosamines / Q000493:pharmacokinetics*; D051381:Rats
D009602:Nitrosamines; D000469:Alkaline Phosphatase