Progressive loss of vision in patients with high-grade non-Hodgkin's lymphoma.
Three cases of double-sided neuritis of the optic nerve in patients with lymphomas are described. Two patients with lymphoblastic lymphoma had no other signs of central nervous system (CNS) relapse. All three cases responded to high doses of corticosteroids and/or radiotherapy, suggesting a lymphomatous cause of the papillitis. Optic nerve involvement is reported to be rare in lymphomas, but may become more prominent with aggressive systemic therapy controlling manifestations outside the CNS. Possible causes of optic neuritis in patients with lymphoma are discussed and therapeutic measures are suggested.
Holte
H
H
Department of Clinical Oncology and Radiotherapy, Norwegian Radium Hospital, Montebello, Oslo.
Saeter
G
G
Dahl
I M
IM
Abrahamsen
A F
AF
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications / Q000556:secondary*; D008727:Methotrexate / Q000008:administration & dosage; D009902:Optic Neuritis / Q000188:drug therapy / Q000209:etiology* / Q000532:radiotherapy; D011241:Prednisone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D000305:Adrenal Cortex Hormones; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone; D008727:Methotrexate