title: Correlation of heterogeneity index score (HIS) of DNA content in bladder cancer recurrence.
abstract: Automated flow cytometry (FCM) has been used to monitor the effects of therapy and progression of human bladder carcinoma. We have previously reported a computer-based model which has shown a correlation to relative mean DNA content in cell populations analyzed by FCM. Two patients with superficial transitional cell carcinoma of the bladder were followed for several months. Using FCM the patients' tissue samples were examined and heterogeneity index scores (HIS) were determined. Both cases had recurrence. The first patient has increased in grade with a respective increase in HIS within four months (grade I----II, HIS 27.2----80.8). The second patient also has recurrence in three months both times with a grade I tumor and a score of 106.2. High scores reflect large aneuploid populations which have shown to recur. Since such a correlation exists HIS may not only offer a more objective technique with quantitative results to monitor patients but possibly can distinguish the degree of tumor malignancy.
authors: Department of Urology, New York Medical College, Valhalla.
authors: K
authors: K
authors: Nakamura
authors: N G
authors: NG
authors: Kasabian
authors: J C
authors: JC
authors: Addonizio
authors: J W
authors: JW
authors: Chiao
authors: M S
authors: MS
authors: Choudhury
authors: G F
authors: GF
authors: Owens
authors: M
authors: M
authors: Tachibana
authors: G R
authors: GR
authors: Nagamatsu
mesh_terms: D000368:Aged; D000782:Aneuploidy; D002295:Carcinoma, Transitional Cell / Q000235:genetics* / Q000628:therapy; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000628:therapy
chemical_list: D004273:DNA, Neoplasm