title: Brain ascorbate depletion as a response to stress.
abstract: Ascorbate-depleted rainbow trout were fed a single dose of L-1-14C-ascorbic acid, then held in metabolism chambers for four consecutive five-day periods. Tissue samples were analyzed for 14C, ascorbate, and ascorbate-2-sulfate. Brain ascorbate showed a long turnover time following a very slow uptake. The loss of brain ascorbate after five days in metabolism chambers was highly significant (p less than 0.001) when compared with similar dosed fish not chambered. A brain ascorbate pool which does not exchange with the body pool is proposed. Possible mechanisms are discussed and a kinetic model is suggested.
authors: College of Ocean and Fisheries Science, Univ. of Wash., Seattle 98195.
authors: B W
authors: BW
authors: Tucker
authors: B M
authors: BM
authors: Tolbert
authors: J E
authors: JE
authors: Halver
authors: M
authors: M
authors: Balaban
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D007700:Kinetics; D012487:Salmonidae / Q000378:metabolism*; D012867:Skin / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism*; D014337:Trout / Q000378:metabolism*
chemical_list: D001205:Ascorbic Acid