[Therapy with plasmapheresis and lymphoplasmapheresis combined with immunosuppressive agents in 2 cases of intractable juvenile rheumatoid arthritis].
Two cases of JRA refractory to NSAID' steroids and long-acting drugs were successfully treated with plasmapheresis and combined lympho- and plasma-apheresis respectively. Case 1. A 8 year old female child who had been suffering from systemic JRA for 6 years received a course of three plasmapheresis followed by a 6 month cycle of azathioprine. Clinical and laboratory remission was promptly achieved and is still present after 18 months. Case 2. A 12-year old boy affected by poliarticular JRA received a course of 4 plasmapheresis followed by a 6 month cycle with azathioprine. The opportunity of performing plasma or lymphoplasmapheresis reinforced by immunosuppressive drugs such as azathioprine or methotrexate at low doses in refractory cases of JRA is discussed.
Lepore
L
L
Clinica Pediatrica dell'Università di Trieste, Italia.
Agosti
E
E
Pitacco
F
F
Panizon
F
F
D001171:Arthritis, Juvenile / Q000628:therapy*; D001379:Azathioprine / Q000627:therapeutic use*; D002648:Child; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007937:Leukapheresis; D008297:Male; D010956:Plasmapheresis
D001379:Azathioprine
Terapia con plasmaferesi e linfoplasmaferesi associata ad immunosoppressore in due casi di artrite reumatoide infantile intrattabile.