HLA and C4 in subacute sclerosing panencephalitis.
The frequencies of HLA-A, B, C, DR and DQ antigens were studied in 63 Japanese patients with subacute sclerosing panencephalitis (SSPE). The results could not confirm the statistical association between SSPE and HLA antigens. In addition, the allele frequencies of complement components C4, C2 and BF were determined in the 20 haplotypes with 10 unrelated SSPE patients. A significant association of C4A QO with SSPE in Caucasians was not found in Japanese.
Harada
F
F
Department of Genetics, Kyushu University, Fukuoka, Japan.
Onisawa
S
S
Suzuki
K
K
Matsumoto
H
H
Sasazuki
T
T
D003175:Complement C2 / Q000235:genetics; D003181:Complement C4 / Q000235:genetics*; D011415:Complement Factor B / Q000235:genetics; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006801:Humans; D007564:Japan; D008297:Male; D013344:Subacute Sclerosing Panencephalitis / Q000235:genetics*
D003175:Complement C2; D003181:Complement C4; D006680:HLA Antigens; D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D011415:Complement Factor B