[Metabolic pool of purine and pyrimidine derivatives in the palatine tonsil of patients with chronic tonsillitis].
Tonsils from 10 patients (18-40 years old), with chronic tonsillitis were studied by means of histological methods as well as by high pressure liquid chromatography. In 5 patients with decompensated forms of the disease, accompanied by heart impairments during 1-3 years, only slight alterations in epithelial and follicular parts of tonsils were observed, while pronounced destruction of tonsil cells was detected in other 5 patients suffering from repeated anginas. The following purine and pyrimidine derivatives were identified in faucial tonsil tissue of all the patients with chronic tonsillitis studied: adenine, guanine, adenosine, guanosine, inosine and uridine. Distinct increase in content of these derivatives as well as occurrence of xanthine and uric acid (non-identified in the first group of patients with chronic tonsillitis) was noted in the patients with maximal destruction of faucial tonsil cells.
Toguzov
R T
RT
Tikhonov
Iu V
IuV
Pimenov
A M
AM
Markusheva
L I
LI
D000293:Adolescent; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D014066:Palatine Tonsil / Q000378:metabolism*; D011687:Purines / Q000378:metabolism*; D011743:Pyrimidines / Q000378:metabolism*; D014069:Tonsillitis / Q000378:metabolism*
D011687:Purines; D011743:Pyrimidines
Metabolicheskiĭ fond purinovykh i pirimidinovykh proizvodnykh tkani nebnykh mindalin u bol'nykh khronicheskim tonzillitom.