[Characteristics of the restructuring of the cardiomyocyte contractile apparatus in chronic ischemic heart disease].
The contractile apparatus of cardiomyocytes was examined at the ultrastructural level in 20 heart biopsy specimens obtained during operations for aortocoronary bypass in patients with chronic ischemic heart disease (IHD). Myofilaments were found to have sustained compensatory-adaptive and destructive changes as well as changes indicative of impaired intracellular regenerations under conditions of chronic hypoxia and energy deficiency experienced by the muscle cells, with the result that myocardial contractility was substantially reduced. Together, these processes led to progressive restructuring of both the contractile apparatus of the cardiomyocytes and the cytoarchitectonics in general. This combined with signs of increasing hyperfunction of the contractile myocardium, which made the energy deficit worse and thus interfered with plastic processes in, and diminished the structural and functional capabilities of, the myocardium. On the other hand, distinct changes were noted in the cardiomyocytes that reflected their adaptation to the adverse conditions created by progressing coronary atherosclerosis. It is concluded that therapy for patients with chronic IHD should include measures aimed at promoting such adaptive changes.
Paukov
V S
VS
Gavrish
A S
AS
D000328:Adult; D000787:Angina Pectoris / Q000473:pathology; D001707:Biopsy, Needle; D002908:Chronic Disease; D003324:Coronary Artery Disease / Q000473:pathology; D003327:Coronary Disease / Q000473:pathology*; D006352:Heart Ventricles / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D009200:Myocardial Contraction; D009206:Myocardium / Q000648:ultrastructure*; D009210:Myofibrils / Q000648:ultrastructure; D005082:Physical Exertion
Osobennosti perestroĭki kontraktil'nogo apparata kardiomiotsitov pri khronicheskoĭ ishemicheskoĭ bolezni serdtsa.