Effect of roxithromycin on acute toxoplasmosis in mice.
Roxithromycin effectively treated acute peritoneal murine toxoplasmosis. After five doses, starting 24 h after challenge, the 100 and 50% survival doses were 540 and 336 mg/kg per day, respectively. After 14 doses, starting 3 h after challenge, the 50% survival dose was 360 mg/kg per day. Toxoplasma gondii was recovered from the brain in 59 and 28% of surviving mice treated with 5 and 14 doses, respectively.
Chang
H R
HR
Department of Microbiology, University of Geneva Medical School, Switzerland.
Pechere
J C
JC
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007933:Leucomycins / Q000627:therapeutic use*; D051379:Mice; D011897:Random Allocation; D014124:Toxoplasmosis, Animal / Q000188:drug therapy*
D007933:Leucomycins