[Effect of thymalin on protein synthesis in the brain and conditioned-reflex activity of the progeny of neurosensitized female rats].
Thymalin administration to two-week-old offspring of neurosensitized female rats prevented the development of protein synthesis disturbances in the central nervous system and the retention of conditioned reflex of passive avoidance. Thymalin injection to the offspring of intact female rats improved conditioned reflex retention and did not affect brain protein synthesis. A possible mechanism of thymalin effect in conditions of congenital neuroimmunopathology is discussed.
Trekova
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D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D001921:Brain / Q000196:embryology / Q000276:immunology* / Q000378:metabolism; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005326:Fetal Proteins / Q000096:biosynthesis; D007154:Immune System Diseases / Q000151:congenital* / Q000209:etiology / Q000517:prevention & control; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D011247:Pregnancy; D051381:Rats; D013951:Thymus Hormones / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D005326:Fetal Proteins; D009419:Nerve Tissue Proteins; D013951:Thymus Hormones; C032805:thymalin
Vliianie timalina na sintez belkov v mozge i uslovnoreflektornuiu deiatel'nost' potomstva neĭrosensibilizirovannykh krys-samok.