title: [Stress-limiting systems and the problem of the prevention of arrhythmia].
abstract: Marked systemic resistance to damaging effects of stress develops as a result of repeated short-term stress exposures. This kind of adaptation is ensured by the activation of stress-limiting systems, namely, the opioidergic, GABA-ergic, serotoninergic, as well as antioxidant and prostaglandin ones. Proceeding from the stress-limiting system concept, adaptation to repeated stress exposure, as well as metabolites, synthetic analogues and activators of stress-limiting systems were successfully used to prevent and eliminate cardiac arrhythmias and fibrillations associated with acute ischemia, myocardial infarction and postinfarction cardiosclerosis. Prospects of further studies of stress-limiting systems' metabolites and activators as antiarrhythmic agents are considered.
authors: F Z
authors: FZ
authors: Meerson
mesh_terms: D000222:Adaptation, Physiological; D001145:Arrhythmias, Cardiac / Q000517:prevention & control* / Q000523:psychology; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D013315:Stress, Psychological / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D005680:gamma-Aminobutyric Acid
vernacular_title: Stress-limitiruiushchie sistemy i problema zaschity ot aritmiĭ.