Skin effects of trichothecenes and their amelioration by decontamination.
The ability of trichothecenes, in particular T2 toxin (T2), to cause irritant effects on the skin has been investigated in laboratory rodents and rabbits. Quantitatively, T2 was found to be highly potent in this respect, causing irritant reactions on rat skin at contamination densities of less than 1 microgram.cm-2. The first appearance of skin effects was delayed for approximately 6 h after application, irrespective of the dose applied. Similarly, variation in solvent or injection into or beneath the skin failed to accelerate the onset of the irritant reaction. An aqueous soap solution was largely effective in removing low doses of T2 from the skin, but was ineffective in removing larger doses. However, washing the contaminated skin with polyethylene glycol 300 was very effective at removing even large doses of T2 from the skin. The macrocyclic trichothecene verrucarin A was of comparable irritancy to T2 on rat skin. Diacetoxyscirpenol and nivalenol were less potent.
Fairhurst
S
S
Biology Division, Ministry of Defence, Porton Down, Salisbury, Wilts.,U.K.
Maxwell
S A
SA
Scawin
J W
JW
Swanston
D W
DW
D000818:Animals; D003666:Decontamination; D004305:Dose-Response Relationship, Drug; D005260:Female; D007509:Irritants; D011092:Polyethylene Glycols / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000633:toxicity*; D012867:Skin / Q000187:drug effects*; D012869:Skin Absorption / Q000187:drug effects; D012915:Soaps; D012997:Solvents; D013605:T-2 Toxin / Q000633:toxicity*
D007509:Irritants; D012717:Sesquiterpenes; D012915:Soaps; D012997:Solvents; D011092:Polyethylene Glycols; D013605:T-2 Toxin