[Antibody formation in the blood and respiratory tract secretions following one-time and repeat immunization with an inactivated influenza vaccine].
Eighty nine volunteers were under study. They were immunized by inactivated vaccine from influenza viruses A(H1N1)+A(H3N2) one time or every year during 4 to 6 years. Vaccine in dosage of 0.2 ml was applied intracutaneously. Under detailed clinical study deflections of health were not over standard. Accumulation of antibodies was determined to immunogens of the vaccine and to virus A/Leningrad/X/83(H3N2), which was in epidemic circulation 3 years later. Intensity of relative increase of antibodies with repeated immunization was 1.5 to 2 times lower. Maximum concentrations of antibodies were found in a week after vaccination. Immunization didn't cause change of titres of secretory antibodies and concentration of immunoglobulin isotopes G, M, A and E in sera and secretions.
Shwartzman
Y S
YS
Allunionsgrippeforschungsinstitut des Ministeriums für Gesundheitswesen der UdSSR, Leningrad.
Ispolatova
A V
AV
Olejnikova
E V
EV
Tzibuljskaya
N V
NV
Grigorjeva
S K
SK
Ivanova
S A
SA
Shadrin
A S
AS
Osipova
M V
MV
Maslennikova
I I
II
Kingo
Z N
ZN
D000328:Adult; D000917:Antibody Formation; D006801:Humans; D007117:Immunization, Secondary; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D008875:Middle Aged; D012137:Respiratory System / Q000276:immunology* / Q000378:metabolism; D014613:Vaccines, Attenuated / Q000276:immunology
D007252:Influenza Vaccines; D014613:Vaccines, Attenuated
Antikörperbildung im Serum und im Sekret des Atemtraktes nach einmaliger und mehrmaliger Immunisierung mit einem inaktivierten Influenzaimpfstoff.