[Lipid peroxidation in the dynamics of experimental toxic adrenal encephalopathy].
TBA-active product plasma content, unsaturated fatty acid level in erythrocyte membrane and peroxide resistance of erythrocytes 1, 7, 15, 30, 45 and 60 days after the onset of experimental toxico-adrenal encephalopathy (ETAE) have been investigated in the peripheral blood of 7 dogs. The first 30 days were characterized by an increase in the indexes indicative of lipid peroxidation (LPO) intensification and a trend towards their further normalization. It is suggested that at early stages of ETAE LPO intensification plays a predominant role in the pathological chemistry of model dystrophic process, while at later stages the leading role is played by other brain metabolism disturbances, associated with LPO activation.
Kovalenko
V M
VM
Vilkov
G A
GA
Stepanenko
E M
EM
Kryzhanovskiĭ
G N
GN
D000818:Animals; D001923:Brain Chemistry; D001927:Brain Diseases / Q000097:blood* / Q000209:etiology; D004285:Dogs; D004910:Erythrocyte Membrane / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood*; D010084:Oxidation-Reduction; D013997:Time Factors
D005231:Fatty Acids, Unsaturated; D008054:Lipid Peroxides
Perekisnoe okislenie lipidov v dinamike éksperimental'noĭ toksiko-adrenalovoĭ éntsefalopatii.