The relation of rhodopsin and scotopic sensitivity in choroideremia.
We examined two patients who had clinical characteristics typical of choroideremia using psychophysical and reflection retinal densitometric techniques. In the dark-adapted state, sensitivity was more compromised than would be predicted on the basis of the modest losses of rhodopsin. In the dark-adapted state, studies of spatial and temporal summation suggested that postreceptoral processes are similar to normal. The kinetics of rhodopsin regeneration after bleaching exposures were abnormal in some retinal regions.
Fulton
A B
AB
Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Hansen
R M
RM
D000328:Adult; D002648:Child; D002829:Choroid; D003623:Dark Adaptation; D003720:Densitometry; D006801:Humans; D008297:Male; D010775:Photic Stimulation; D012160:Retina / Q000503:physiopathology*; D012168:Retinal Pigments / Q000502:physiology*; D012243:Rhodopsin / Q000502:physiology*; D014603:Uveal Diseases / Q000235:genetics / Q000503:physiopathology
D012168:Retinal Pigments; D012243:Rhodopsin