title: The influence of some antidepressant drugs on the nuclear volume of rat cingular cortex cells in culture.
abstract: The changes in the volume of cell nuclei of the rat cingular cortex were investigated in culture after incubation with some antidepressant drugs. Two-week incubation of the cingular cortex culture with both tricyclic (desipramine, imipramine, amitryptyline) and non-tricyclic (mianserin) antidepressants in concentration of 3 X 10(-6) M resulted in a decrease of the volume of the cell nuclei. Because the size of the nucleus is regarded as a criterion of the cell metabolic activity, our results may point to a diminished activity of metabolic processes of the cells.
authors: Institute of Pharmacology, Polish Academy of Sciences, Kraków.
authors: A
authors: A
authors: Bal
authors: M
authors: M
authors: Smiałowska
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D002467:Cell Nucleus / Q000187:drug effects* / Q000648:ultrastructure; D002478:Cells, Cultured; D006179:Gyrus Cinguli / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic