Serum concentrations of salicylate and naproxen during concurrent therapy in patients with rheumatoid arthritis.
The kinetic interaction between salicylate and naproxen was investigated in 25 rheumatoid arthritis patients. Kinetic interactions were tested in serum after patients had been on each drug regimen for 1 month. Salicylate decreased serum naproxen concentration from 89.5 mg/liter to 65.9 mg/liter (P less than 0.001) and increased serum naproxen clearance by 56%. Naproxen had minimal effect on serum salicylate concentrations.
Furst
D E
DE
Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City.
Sarkissian
E
E
Blocka
K
K
Cassell
S
S
Dromgoole
S
S
Harris
E R
ER
Hirschberg
J M
JM
Josephson
N
N
Paulus
H E
HE
D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D002794:Choline / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D004311:Double-Blind Method; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009288:Naproxen / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011897:Random Allocation; D012459:Salicylates / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
D012459:Salicylates; D009288:Naproxen; C017959:choline magnesium trisalicylate; D002794:Choline