[Sensitivity of clonogenic cells of human ascitic ovarian cancer to antitumor agents].
A soft agar colony assay using diffusion chamber technique in vivo for studying the sensitivity to chemotherapeutic agents of clonogenic tumor cells of primary ovarian carcinoma was used. The highest cytotoxic sensitivity on human clonogenic tumour cells was observed to cyclophosphamide and 5-fluorouracil. The sensitivity of human ovarian carcinoma to chemotherapeutic agents was dependent essentially on the presence of macrophage in cell culture.
Potapov
S L
SL
Korman
D B
DB
Shamaev
V I
VI
Ershova
R B
RB
Makarov
O V
OV
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014410:Tumor Stem Cell Assay
D000970:Antineoplastic Agents; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D005472:Fluorouracil
Chuvstvitel'nost' klonogennykh kletok astsitnogo raka iachnikov cheloveka k protivoopukholevym preparatam.