High grade dysplasia in Crohn's colitis characterized by flow cytometry.
A patient with Crohn's ileocolitis had high grade dysplasia. Preoperative evaluation of colonoscopic biopsies by flow cytometry demonstrated aneuploidy, a marker of malignancy. In the surgical specimen, however, carcinoma was not demonstrated despite extensive sampling. The detection of abnormal DNA content in this premalignant lesion suggests a useful role for this technique in selecting those patients with inflammatory bowel disease at risk for carcinoma.
McKinley
M J
MJ
Department of Medicine, North Shore University Hospital, Manhasset, NY 11030.
Budman
D R
DR
Kahn
E
E
D000782:Aneuploidy; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000209:etiology* / Q000473:pathology; D003424:Crohn Disease / Q000150:complications / Q000473:pathology*; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000209:etiology* / Q000473:pathology