Association of multiple copies of the c-erbB-2 oncogene with spread of breast cancer.
Amplification of c-erbB-2 was at least three times more frequent in breast cancer than in most other types of carcinoma, and was not found in sarcomas or hematological malignancies. Amplification of c-erbB-2 was found in 15 of 86 primary breast cancers and in 3 of 12 secondary breast cancers. Amplification was more common in breast tumors of advanced stage, and in tumors which had metastasized to regional lymph nodes sites. Gene amplification was observed in 21% (4 of 19) of primary tumors which recurred within 3 years of mastectomy and in 6% (2 of 32) of nonrecurrent tumors.
Zhou
D
D
Department of Medicine, University of California, Los Angeles 90024.
Battifora
H
H
Yokota
J
J
Yamamoto
T
T
Cline
M J
MJ
D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D005260:Female; D005784:Gene Amplification; D005787:Gene Frequency; D006801:Humans; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D011379:Prognosis; D011519:Proto-Oncogenes