Skeletal abnormalities of acrogeria, a progeroid syndrome.
We report the skeletal abnormalities in a 4 1/2-year-old boy with acrogeria, a progeroid syndrome of premature aging of the skin without the involvement of internal organs seen in Hutchinson-Gilford progeria syndrome. Acro-osteolysis of the distal phalanges, delayed cranial suture closure with wormian bones, linear lucent defects of the metaphyses, and antegonial notching of the mandible are the predominant skeletal features of the disorder. The skeletal features described in 21 other reported cases of acrogeria are summarized.
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Department of Radiology (Section of Pediatric Radiology), University of Michigan Medical Center, Ann Arbor.
White
S J
SJ
Rasmussen
J E
JE
D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002675:Child, Preschool; D005271:Femur Head Necrosis / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D010014:Osteolysis / Q000000981:diagnostic imaging; D011371:Progeria / Q000000981:diagnostic imaging*; D011859:Radiography