The effect of dietary polyunsaturated fat on cation transport and hypertension in the rat.
1. Essential hypertension is associated with increased intracellular sodium in both erythrocytes and leucocytes. Reports in the literature indicate that increasing the level of polyunsaturated fat in the diet reduces hypertension. In the present study, spontaneously hypertensive rats (Wistar-Kyoto, which develop systolic blood pressures in excess of 140 mmHg by 8 weeks of age) were fed on high-fat diets (40% energy derived from fat), the fat being maize oil (high in polyunsaturated fatty acids, PUFA) and coconut oil (low in PUFA). 2. Significantly higher blood pressures developed by 110 d of age in the rats fed on a high-PUFA diet, compared with those fed on the low-PUFA diet. 3. In thymocytes, ouabain-sensitive efflux rate constants were significantly lower in the group fed on the high-PUFA diet. Ouabain-insensitive efflux rate constants were unaffected by diet.
Murray
G E
GE
Department of Biochemistry, University of Ottawa, Canada.
Nair
R
R
Patrick
J
J
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004041:Dietary Fats / Q000627:therapeutic use*; D005224:Fats, Unsaturated / Q000627:therapeutic use*; D006973:Hypertension / Q000178:diet therapy* / Q000503:physiopathology; D050356:Lipid Metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D012964:Sodium / Q000378:metabolism*; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism
D004041:Dietary Fats; D005224:Fats, Unsaturated; D012964:Sodium