Separation of some enantiomeric di- and tripeptides on chiral stationary phases.
The chromatographic behavior of the N-3,5-dinitrobenzoyl derivatives of twelve dipeptide esters and two tripeptide esters was investigated on three different chiral stationary phases (CSPs). It is observed that the stereoisomers present in each sample may be cleanly separated on each chiral phase. A degree of regularity is noted in the elution order of the enantiomers and often of the diastereomers. Elution order of the enantiomers is related to a chiral recognition model for each CSP.
Pirkle
W H
WH
Roger Adams Laboratory, School of Chemical Sciences, University of Illinois, Urbana 61801.
Alessi
D M
DM
Hyun
M H
MH
Pochapsky
T C
TC
D000596:Amino Acids / Q000032:analysis; D004151:Dipeptides / Q000032:analysis*; D009842:Oligopeptides / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D000596:Amino Acids; D004151:Dipeptides; D009842:Oligopeptides