A comparison of schedules combining fractionated hyperthermia and irradiation in mice.
A comparison was made of three study arms delivering localized fractionated hyperthermia followed by irradiation for two weeks. The treatment results demonstrated 18-week survival and NED survival to be 35 per cent (7/20) and 30 per cent (6/20) respectively for heat and irradiation 5 days per week, 57.9 per cent (11/19) and 52.6 per cent (10/19) for combined treatment 3 days per week and 27.8 per cent (5/18) for heat 3 days per week and irradiation 5 days per week. It is felt that thermotolerance will account for the lack of difference between 24 h and 48 h irradiation schedules when irradiation is given daily. Irradiation fraction size, however, is suggested as a moderating variable as well.
Morphis
J G
JG
Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis.
Hornback
N B
NB
Slater
J M
JM
Nutter
R L
RL
Barrett
A S
AS
D000818:Animals; D003131:Combined Modality Therapy; D006979:Hyperthermia, Induced / Q000379:methods*; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D013997:Time Factors