[Changes in the secondary structure of collagen after gamma-irradiation in an aqueous solution].
The conformation of calf skin collagen at the secondary structure level changed after 60Co-gamma-radiation with doses ranging from 50 to 1,000 Gy in aerated aqueous solutions and in the presence of N2 and N2O. Despiralization of collagen at a dose of 1,000 Gy reached 90% in N2O, 70% in N2, and 60% in the aerated solution. The radiochemical yield of the despiralized collagen molecules was 0.007 mol/100 eV owing to OH(.). The presence of radioprotective agents upon irradiation of collagen solutions diminished considerably the injury to its secondary structure.
Duzhenkova
N A
NA
Klimova
T P
TP
D000818:Animals; D002417:Cattle; D002942:Circular Dichroism; D003094:Collagen / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D066298:In Vitro Techniques; D011487:Protein Conformation / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000494:pharmacology; D012996:Solutions
D011837:Radiation-Protective Agents; D012996:Solutions; D003094:Collagen
Izmenenie vtorichnoĭ struktury kollagena pri gamma-obluchenii v vodnom rastvore.