Chronic dihydroergotoxine administration increases muscarinic cholinergic receptor binding in aged-rat brain.
Changes in the distribution and densities of muscarinic cholinergic receptors (mCh-R) and the effects of dihydroergotoxine (DHET) administration on these changes were studied in the aged-rat brain by in vitro autoradiography. mCh-R binding in the brain was markedly reduced in aged rats as compared with young adult rats, but chronic administration of DHET specifically recovered mCh-R binding in the temporal cortex and hippocampus.
Ogawa
N
N
Institute for Neurobiology, Okayama University Medical School, Japan.
Mizukawa
K
K
Sora
I
I
D000375:Aging; D000818:Animals; D001345:Autoradiography; D001923:Brain Chemistry / Q000187:drug effects*; D004088:Dihydroergotoxine / Q000494:pharmacology*; D008297:Male; D008568:Memory; D010275:Parasympathetic Nervous System / Q000502:physiology; D051381:Rats; D011916:Rats, Inbred F344; D011976:Receptors, Muscarinic / Q000032:analysis / Q000187:drug effects*
D011976:Receptors, Muscarinic; D004088:Dihydroergotoxine