title: Critical aortic stenosis. Survival and management.
abstract: The factors associated with survival in 40 neonates (age less than 28 days) with critical aortic stenosis undergoing either open (22 patients) or closed (18 patients) transventricular aortic valvotomy were reviewed. Significant adverse correlates with survival included evidence of poor perfusion preoperatively (low pH, greater than Grade 2/6 soft ejection systolic murmur) and marked congestive heart failure (hepatomegaly, cardiomegaly, elevated left atrial pressure). Congenital mitral stenosis (anulus less than 11 mm), a small aortic anulus (less than 6.5 mm), and failure to achieve an adequate aortic orifice (greater than 6 mm), at operation were identified as factors associated with increased mortality. Initial perioperative survival was better with closed aortic valvotomy. However, there was no significant difference in overall operative survival between closed (9/18, 50%) and open (8/22, 36%) aortic valvotomy (p = 0.26). The incidence of early reoperation (less than 1 year of age) was greater in perioperative survivors undergoing closed valvotomy (7/13, 54%) rather than open valvotomy (1/10, 10%) (p less than 0.05). In conclusion, long-term survival among patients with critical neonatal aortic valve stenosis remains disturbingly low (13/40, 32%) and has not significantly improved over the past 20 years.
authors: Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
authors: A N
authors: AN
authors: Pelech
authors: J D
authors: JD
authors: Dyck
authors: G A
authors: GA
authors: Trusler
authors: W G
authors: WG
authors: Williams
authors: P M
authors: PM
authors: Olley
authors: R D
authors: RD
authors: Rowe
authors: R M
authors: RM
authors: Freedom
mesh_terms: D001021:Aortic Valve / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D006328:Cardiac Catheterization; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008722:Methods; D008944:Mitral Valve Insufficiency / Q000150:complications; D012086:Reoperation; D012189:Retrospective Studies