[Nasal concentrations of fusafungin following administration of a dosage aerosol (Locabiosol)].
Following investigations on content uniformity and of the drug content delivered per each dose from a pressurised aerosol (Locabiosol) the concentration of the locally acting antibiotic fusafungin was determined in nasal secretions of volunteers. Quantitative HPLC-assay of fusafungin was performed following the extraction of cotton swabs used to collect nasal secretions. The volume of the nasal secretions results from the mass difference of the swabs before and after application. The concentrations of fusafungin measured on 41 volunteers over a period of 3 hrs were evidently higher than the minimum inhibitory concentrations reported in literature. The results of controlled clinical studies of other authors are in agreement with these results.
Rohdewald
P
P
Institut für Pharmazeutische Chemie, der Westfälischen Wilhelms-Universität Münster.
Lohmann
A
A
D000328:Adult; D000336:Aerosols / Q000008:administration & dosage / Q000493:pharmacokinetics; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D047630:Depsipeptides; D005260:Female; D005670:Fusarium; D006801:Humans; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*
D000336:Aerosols; D000900:Anti-Bacterial Agents; D047630:Depsipeptides; C014001:fusafungin
Nasale Konzentrationen von Fusafungin nach Applikation eines Dosieraerosols (Locabiosol).