Acute megakaryocytic leukemia. Flow cytometric analysis of DNA content at diagnosis and during the course of therapy.
Flow cytometry (FCM) for the determination of DNA content and cell cycle analysis was performed on multiple bone marrows from a case of acute megakaryocytic leukemia in a 71-year-old woman. Two aneuploid (multiploid) peaks were present at diagnosis. This multiploidy was a stable characteristic when studied temporally. The disappearance of the peaks in the bone marrow specimens directly correlated with complete remission morphologically. These findings further support the concept of FCM as an adjunct to morphologic study in identifying residual tumor burden.
Pantazis
C G
CG
Department of Pathology, Medical College of Georgia, Augusta 30907.
Allsbrook
W C
WC
Ades
E
E
Houston
J
J
Brubaker
L H
LH
D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000175:diagnosis; D000782:Aneuploidy; D002295:Carcinoma, Transitional Cell; D002453:Cell Cycle; D004247:DNA / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D013920:Thrombocythemia, Essential / Q000175:diagnosis* / Q000628:therapy; D001749:Urinary Bladder Neoplasms
D004247:DNA