[Dynamics of levels of 3-OAK antigens and ascorbic acid in the liver of rats and mice during hepatocarcinogenesis].
Dynamics of the content of 3-OAK-A in the liver, blood and urine as well as of free and bound AK in the liver of rats and mice was traced by the quantitative precipitation reaction and oxidimetric method of ascorbic acid (AA) determination. It was shown that an increase in the content of 3-OAK-A in the liver during carcinogenesis initiation and progression is accompanied by a decrease in the AA content in this organ. One of the possible mechanisms inhibiting the formation of 3-OAK-A is "interception" of the proteins involved in the formation of 3-OAK-A.
Korosteleva
T A
TA
Shvaĭdetskiĭ
I I
II
D015095:3-Hydroxyanthranilic Acid / Q000276:immunology*; D000818:Animals; D000941:Antigens / Q000032:analysis*; D001205:Ascorbic Acid / Q000378:metabolism*; D008099:Liver / Q000276:immunology / Q000378:metabolism*; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000276:immunology / Q000378:metabolism; D008297:Male; D051379:Mice; D051381:Rats; D009762:o-Aminoazotoluene; D062367:ortho-Aminobenzoates / Q000276:immunology*
D000941:Antigens; D062367:ortho-Aminobenzoates; D015095:3-Hydroxyanthranilic Acid; D001205:Ascorbic Acid; D009762:o-Aminoazotoluene
Dinamika soderzhaniia 3-OAK-antigenov i askorbinovoĭ kisloty v pecheni krys i mysheĭ pri gepatokantserogeneze.