Immunogenicity of injectable collagen implants.
The presence of antibodies to bovine and human collagens used in injectable collagen implants (ICI) was investigated in 103 normal sera. Significant levels of spontaneous nonprecipitin antibodies were observed, suggesting that immunization to ICI compounds may preexist even in the absence of connective tissue disease.
Sellem
P H
PH
Laboratoire d'Immunologie, UFR Sciences Médicales, Vandoeuvre les Nancy, France.
Caranzan
F R
FR
Bene
M C
MC
Faure
G C
GC
D000906:Antibodies / Q000032:analysis*; D003094:Collagen / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D011234:Precipitins / Q000276:immunology; D019736:Prostheses and Implants; D011897:Random Allocation
D000906:Antibodies; D007074:Immunoglobulin G; D011234:Precipitins; D003094:Collagen