Papulacandins--synthesis and biological activity of papulacandin B derivatives.
A series of papulacandin B derivatives was synthesized and their in vitro and in vivo activity against Candida albicans and other fungi was established. The biological data have shown that some 10-alkyl ether and 11-acylamino derivatives exhibit an improved in vivo activity compared to papulacandin B whereas derivatization in other positions of the molecule led to less potent compounds.
Traxler
P
P
Research Department, CIBA-GEIGY Limited, Basel, Switzerland.
Tosch
W
W
Zak
O
O
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D054714:Echinocandins; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054714:Echinocandins; C014732:papulacandins