title: Systemic distribution of blood flow in ponies during 1.45%, 1.96%, and 2.39% end-tidal isoflurane-O2 anesthesia.
abstract: Effects of 1.1, 1.5, and 1.8 minimal alveolar concentration (MAC) isoflurane-O2 (1.45%, 1.96%, and 2.39% end-tidal isoflurane, respectively) anesthesia on cardiac output, blood pressure, and blood flow to the brain, thyroid glands, adrenal glands, kidneys, and splanchnic organs were examined in 9 healthy isocapnic adult ponies. Tissue blood flows were studied using 15-micron diameter radionuclide-labeled microspheres that were injected into the left ventricle, and comparisons were made with data obtained from ponies in the conscious state. Isoflurane anesthesia caused dose-related reduction in cardiac output and arterial blood pressure, but total peripheral resistance was not significantly altered (P greater than 0.05). In the brain, vasodilation occurred with exposure to isoflurane that peaked at 1.5 MAC. Vasodilation was more pronounced in the cerebellum, pons, and medulla, compared with that in the cerebrum. Perfusion increased in cerebellar gray, as well as white, matter. However, in the cerebrum, blood flow increased in the white matter, whereas it decreased in caudate nuclei and was similar to value in the cortex of awake ponies. In thyroid glands and pancreas, intense vasoconstriction occurred during isoflurane anesthesia which caused precipitous reduction in blood flow in these organs. By contrast, adrenal gland blood flow was not affected during the 3 levels of isoflurane anesthesia because vasodilation occurred. The renal blood flow registered dose-dependent reductions during isoflurane-O2 anesthesia, but renal vasoconstriction occurred only during the deepest level (1.8 MAC) of anesthesia. Although the small intestine and and colon blood flow decreased with each concentration of isoflurane, the splenic blood flow remained unaffected.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana, Champaign 61801.
authors: M
authors: M
authors: Manohar
authors: R
authors: R
authors: Gustafson
authors: T E
authors: TE
authors: Goetz
authors: D
authors: D
authors: Nganwa
mesh_terms: D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D001933:Brain Stem / Q000098:blood supply; D002302:Cardiac Output / Q000187:drug effects; D002531:Cerebellum / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006736:Horses / Q000502:physiology*; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D007530:Isoflurane