Multivariate analysis of ambient environmental factors and respiratory effects.
Relationships between respiratory health and environmental conditions (pollen, pollution and meteorology) are investigated in 204 subjects in four symptom groups in four geographical clusters in Tucson. Techniques used are principal components, factor and path analysis. Daily respiratory symptoms and peak expiratory flows were recorded during a three-year period. Ambient pollutants, meteorological conditions and pollen types were monitored in or near the clusters. Factor-based scales, which are climate and season specific, are developed for the environmental variables. Three pollutant/meteorological scales represent 'Summer', 'Winter', and 'Humidity'. Four pollen scales represent early and late spring, summer and fall pollen types. Relationships between environmental variables, respiratory symptoms and peak expiratory flow are analyzed with path diagrams, after accounting for age, sex, smoking habits and stove type. The different effects of the environment on asthmatics, allergics and airways obstructive disease subjects have been demonstrated. Many relationships were found between environmental factors and respiratory responses. The pollutant and meteorological variables are related to respiratory symptoms and peak flow directly as well as through interactions with pollen types. Some of the largest positive coefficients are seen in association with seasonal pollen types, specifically, rhinitis and dyspnoea.
Holberg
C J
CJ
University of Arizona Health Sciences Center, College of Medicine, Division of Respiratory Sciences, Tucson 85724.
O'Rourke
M K
MK
Lebowitz
M D
MD
D000328:Adult; D000397:Air Pollution / Q000032:analysis*; D000704:Analysis of Variance; D001130:Arizona; D001249:Asthma / Q000453:epidemiology; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000453:epidemiology; D008297:Male; D011058:Pollen; D012130:Respiratory Hypersensitivity / Q000453:epidemiology; D012140:Respiratory Tract Diseases / Q000453:epidemiology*; D012621:Seasons; D014887:Weather