Specific angiotensin II binding sites in the rat stellate and superior cervical ganglia.
Angiotensin II binding sites were localized and quantified in rat stellate and superior cervical ganglia by quantitative autoradiography using 125I-Sar1-angiotensin II as a ligand. Both ganglia possess a single class of angiotensin II binding sites. High concentrations of binding sites were localized in the areas rich in principal ganglion cells. These binding sites might mediate the facilitatory action of angiotensin II on the ganglionic transmission.
Castrén
E
E
Unit on Preclinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20982.
Kurihara
M
M
Gutkind
J S
JS
Saavedra
J M
JM
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D005728:Ganglia, Sympathetic / Q000166:cytology / Q000378:metabolism*; D007457:Iodine Radioisotopes; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains; D011945:Receptors, Angiotensin / Q000378:metabolism*
D007457:Iodine Radioisotopes; D011945:Receptors, Angiotensin; D000804:Angiotensin II