[Mechanisms of realization of stimulating effects of serotonin on immune processes].
Low dosages of serotonin and 5-hydroxytryptophan were found to stimulate rosette-forming process in spleens of male CBA mice (5 X 10(6)) immunized with sheep red blood cells, in contrast to high dosages that are known to induce inhibition. The above finding suggests a bimodality of serotoninergic immunomodulation. Immune responses were compared between shamoperated, adrenalectomized, thymectomized mice and mice with lesion of hypothalamo-pituitary complex (the destruction of pituitary or its stalk). It was shown, that neither hypothalamo-pituitary-adrenal system by means of which the inhibitory effect of serotonin (high dose) was released, no thymus, where the increase of rosette-forming process was released in adrenalectomized mice which obtained high doses of serotonin. The dosage-response curve suggests mediating of opposite serotonin effects via serotonin reactive structures with different serotonin sensitivity.
Eliseeva
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D000315:Adrenalectomy; D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007109:Immunity; D007114:Immunization; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012397:Rosette Formation; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology*; D013950:Thymus Gland / Q000502:physiology
D012701:Serotonin
K mekhanizmam realizatsii stimuliruiushchikh éffektov serotonina na immunnye protsessy.