Dose-dependent antinociceptive action of neurotensin microinjected into the rostroventromedial medulla of the rat.
Microinjection of neurotensin into the rat rostroventromedial medulla produces dose-dependent inhibition of the tailflick reflex (ED50 of 2.06 nmol/animal (1.33-3.19)). The peak effect occurs 15-20 min following injection and, at the highest dose used, lasts up to 70 min.
Fang
F G
FG
Department of Neurology, University of California, San Francisco 94143.
Moreau
J L
JL
Fields
H L
HL
D000698:Analgesia; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D009496:Neurotensin / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement; D051381:Rats; D011919:Rats, Inbred Strains
D009496:Neurotensin