Mutagenicity of instant coffee and its interaction with dimethylnitrosamine in the micronucleus test.
The mutagenicity of instant coffee and its interaction with dimethylnitrosamine (DMN) were examined in mice using the micronucleus test. Although neither a single nor multiple administration of instant coffee by gavage induced a significant rise in micronucleated cells over the dose range tested (100-2500 mg/kg), there was a tendency for the number of micronucleated cells to increase in a dose-related fashion. When coffee was administered with DMN, the difference in the frequency of micronucleated cells was small in comparison to a single treatment with DMN alone, thus indicating a lack of synergism between coffee and DMN.
Shimizu
M
M
Department of Environmental Health, Faculty of Health Sciences, University of Kyorin, Japan.
Yano
E
E
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002467:Cell Nucleus / Q000187:drug effects* / Q000648:ultrastructure; D003069:Coffee; D004128:Dimethylnitrosamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008658:Inactivation, Metabolic; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D009152:Mutagenicity Tests
D003069:Coffee; D004128:Dimethylnitrosamine