Use of chemically-bonded cyclodextrin stationary phase for high performance liquid chromatographic determination of feldene capsules.
A novel high performance liquid chromatographic method (HPLC) is presented for the quantitative determination of piroxicam in capsule formulation (Feldene capsule). Samples are separated on a chemically bonded beta-cyclodextrin column (Cyclobond I) with a mobile phase of 75% 0.05M phosphate buffer (pH 7.0) and 25% methanol. The effluent is monitored by a spectrophotometric detector with a 254-nm filter. The method is rapid, accurate, and precise.
Ahmed
A N
AN
College of Pharmacy, Department of Pharmaceutical Chemistry, University of Assiut, Egypt.
el-Gizawy
S M
SM
D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D003505:Cyclodextrins / Q000032:analysis*; D003912:Dextrins / Q000032:analysis*; D010894:Piroxicam / Q000032:analysis*; D012996:Solutions; D013213:Starch / Q000032:analysis*
D002214:Capsules; D003505:Cyclodextrins; D003912:Dextrins; D012996:Solutions; D010894:Piroxicam; D013213:Starch