Cumulative pregnancy rates for donor insemination according to ovulatory function and tubal status.
From our study of 234 cases of AID with fresh semen, we conclude the following: (1) women who do not have other infertility problems, such as ovulatory dysfunction or evidence of tubal disease, have approximately a 90% chance of pregnancy if they stay in the program for up to 12 cycles; (2) with even greater persistence (i.e., greater than 12 cycles), it is predicted that virtually 100% of these women would conceive, but this conclusion is based on extrapolated data and therefore must be interpreted with caution; (3) women with ovulatory dysfunction who are treated with CC during their AID cycles ultimately achieve the same likelihood of pregnancy as women with normal ovulatory function, but at a slower rate; and (4) women with one patent tube (possibly a marker for generalized tubal damage) have a poorer outcome from AID than those with bilaterally patent tubes, from the standpoint of both the ultimate likelihood of pregnancy and the pregnancy rate per cycle.
Bradshaw
K D
KD
Department of Obstetrics and Gynecology, University of Texas Health Science Center, Dallas.
Guzick
D S
DS
Grun
B
B
Johnson
N
N
Ackerman
G
G
D000328:Adult; D000367:Age Factors; D002996:Clomiphene / Q000627:therapeutic use; D005187:Fallopian Tubes / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology; D007315:Insemination, Artificial; D007316:Insemination, Artificial, Heterologous; D010060:Ovulation; D010062:Ovulation Induction; D011247:Pregnancy
D002996:Clomiphene