title: Effect of decreasing the dose rate of irradiation on the mouse lip mucosa. Comparison with fractionated irradiations.
abstract: The effect of continuous irradiation, delivered at five different dose rates (642, 76.8, 14.1, 2.9 and 1.5 Gy.h-1), has been investigated using the mouse lip mucosa. There was a striking dose rate effect (DRE) below 14.1 Gy.h-1 while above this dose rate the DRE was relatively small. No DRE was observed between irradiations delivered at 642 and 76.8 Gy.h-1. A comparison was made with the previously published results of high dose rate (84 Gy.h-1) fractionated irradiation (2, 4, 10 and 20 fractions). For both types of irradiation treatment an alpha/beta value of 7.4 Gy and a half-time for repair of 47 min was derived.
authors: Department of Experimental Radiotherapy, University Hospital St. Rafaël, Leuven, Belgium.
authors: P
authors: P
authors: Scalliet
authors: W
authors: W
authors: Landuyt
authors: E
authors: E
authors: van der Schueren
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008046:Lip / Q000528:radiation effects*; D051379:Mice; D009061:Mouth Mucosa / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000209:etiology*