Effect of decreasing the dose rate of irradiation on the mouse lip mucosa. Comparison with fractionated irradiations.
The effect of continuous irradiation, delivered at five different dose rates (642, 76.8, 14.1, 2.9 and 1.5 Gy.h-1), has been investigated using the mouse lip mucosa. There was a striking dose rate effect (DRE) below 14.1 Gy.h-1 while above this dose rate the DRE was relatively small. No DRE was observed between irradiations delivered at 642 and 76.8 Gy.h-1. A comparison was made with the previously published results of high dose rate (84 Gy.h-1) fractionated irradiation (2, 4, 10 and 20 fractions). For both types of irradiation treatment an alpha/beta value of 7.4 Gy and a half-time for repair of 47 min was derived.
Scalliet
P
P
Department of Experimental Radiotherapy, University Hospital St. Rafaël, Leuven, Belgium.
Landuyt
W
W
van der Schueren
E
E
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008046:Lip / Q000528:radiation effects*; D051379:Mice; D009061:Mouth Mucosa / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000209:etiology*