title: Renal effects of prednisolone in the chicken.
abstract: The effects of prednisolone on renal tubular transport of organic ions, urine flow and glomerular filtration rate were studied using the Sperber preparation in chickens. Low infusion rates of 1 and 5 nmole/min prednisolone slightly enhanced organic ion excretion. At higher infusion rates up to 1,000 nmol/min, no change in organic ion transport was observed. Urine flow and glomerular filtration rate increased at prednisolone infusion rates of 50 nmole/min and higher, independent of changes in renal blood flow.
authors: Department of Pediatrics, Childrens Hospital, Buffalo, New York 14222.
authors: J
authors: J
authors: Springate
authors: D
authors: D
authors: Jeffery
authors: M
authors: M
authors: Acara
mesh_terms: D000818:Animals; D002645:Chickens; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007444:Inulin; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D011239:Prednisolone / Q000494:pharmacology*; D013757:Tetraethylammonium Compounds; D010130:p-Aminohippuric Acid
chemical_list: D013757:Tetraethylammonium Compounds; D007444:Inulin; D011239:Prednisolone; D010130:p-Aminohippuric Acid