Factors affecting motility and morphology of Cryptosporidium sporozoites in vitro.
In vitro motility and morphology of Cryptosporidium sporozoites were examined in the presence of various solutions. Crude preparations of the bile salt, taurocholic acid, maintained both motility and morphology in a dose-dependent manner. These effects appeared to be due to the taurocholic acid itself, and not simply due to pH variations, osmotic factors, or contaminants. Lysis of sporozoites was also observed and was found to be dependent on pH, with acidic conditions (pH less than 6.2) triggering the lysis.
Woodmansee
D B
DB
Department of Zoology, Iowa State University, Ames.
Powell
E C
EC
Pohlenz
J F
JF
Moon
H W
HW
D000818:Animals; D002465:Cell Movement; D003044:Coccidia / Q000502:physiology*; D003458:Cryptosporidium / Q000187:drug effects / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D003470:Culture Media; D006863:Hydrogen-Ion Concentration; D009994:Osmolar Concentration; D013656:Taurocholic Acid / Q000494:pharmacology
D003470:Culture Media; D013656:Taurocholic Acid