title: The influence of propranolol and glucagon on the pharmacokinetics of antipyrine and sodium salicylate.
abstract: Propranolol (1) decreases hepatic blood flow and glucagon (2) exerts an opposite effect on hepatic circulation. The effects of these drugs on the pharmacokinetics of phenazone (3; antipyrine)-a compound with low coefficient of hepatic extraction, and sodium salicylate (4) that is highly extracted by liver, were studied on rabbits. It was shown that changes in the pharmacokinetics of 3 and 4 in the presence of 1 or 2, seemed to be interactions between these drugs in the haemodynamic phase.
authors: Department of Pharmacodynamics, Medical Academy, Lodź, Poland.
authors: D
authors: D
authors: Orszulak-Michalak
authors: P
authors: P
authors: Kaszubski
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics*; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D006207:Half-Life; D008102:Liver Circulation / Q000187:drug effects; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits; D012459:Salicylates / Q000493:pharmacokinetics*; D020156:Salicylic Acid
chemical_list: D012459:Salicylates; D005934:Glucagon; D011433:Propranolol; D020156:Salicylic Acid; D000983:Antipyrine