HLA-A,B,C and DR antigens in a sample of the Tunisian population.
The HLA-A, B and DR phenotypes of 109 unrelated Tunisian individuals have been determined. The HLA-A and B antigen frequencies were compared with data reported for European Caucasoids and various Arab populations. Most similarities in antigen frequencies were seen between Tunisians and Kabyles from North Africa. A high frequency of HLA-A23 and HLA-Bw50 was observed in Tunisians and all Arab populations. A very close similarity in HLA-DR antigen frequencies exists between Tunisians and European Caucasoids. Linkage disequilibria between alleles of HLA loci were examined; many instances of previously reported antigen associations were seen in Tunisians, together with a number of associations which have not been described elsewhere. Aw34B8 and A2DRw14 are suggested as being common haplotypes in Tunisians.
Ayed
K
K
Laboratoire d'Immunologie, Faculté de Médecine de Tunis, Tunisia.
Bardi
R
R
Gebuhrer
L
L
Gorgi
Y
Y
Betuel
H
H
D000328:Adult; D005006:Ethnicity; D005787:Gene Frequency; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006681:HLA-D Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D010641:Phenotype; D014416:Tunisia
D006680:HLA Antigens; D006681:HLA-D Antigens; D006684:HLA-DR Antigens