[Effect of therapeutic administration of purine derivatives on the life span of irradiated animals].
Purine derivatives, meradine and ethimizole, are shown to exert a therapeutic effect with respect to survival of rats exposed to 4 Gy radiation. Distinctions in the death rate between the exposed rats and rats treated with meradine and ethimizole are manifested 1 month following irradiation, i. e. at the time of clinical recovery of the exposed body. The preparations used at other te terms are uneffective. It is suggested that purine derivatives increase the regeneration and compensation of radiation lesions at the time of clinical recovery reducing an irreversible component of radiation damage.
Prokudina
E A
EA
Borovitskaia
A E
AE
Kadyrova
N O
NO
Rzhononitskaia
L P
LP
D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D005042:Etimizol / Q000627:therapeutic use*; D007031:Hypothalamus / Q000378:metabolism / Q000528:radiation effects; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality*; D011837:Radiation-Protective Agents; D051381:Rats; D013997:Time Factors
D002395:Catecholamines; D007093:Imidazoles; D011837:Radiation-Protective Agents; C001700:meradine; D000225:Adenine; D005042:Etimizol
Vliianie terapevticheskogo primeneniia purinovykh proizvodnykh na prodolzhitel'nost' zhizni obluchennykh zhivotnykh.