Dietary carbohydrate assimilation in the premature infant: evidence for a nutritionally significant bacterial ecosystem in the colon.
Carbohydrate energy absorption and breath hydrogen concentration were measured in 12 premature infants 28-32 wk gestational age and 2-4 wk postnatal age. Each of two groups of six infants were randomly assigned to receive one of two formulas that differed only in carbohydrate source: 100% lactose (LAC) or 50% lactose: 50% glucose polymer (LAC + GP). In 11 infants the peak breath hydrogen concentration suggested extensive colonic fermentation (range 44-239 ppm/5% CO2 or 44-239 microL/L per 50 mL/L CO2). An approximate 100% increase in lactose intake in the LAC group was associated with a similar increase in breath hydrogen concentration at 30, 60, and 120 min. None of the infants exhibited diarrhea or vomiting or developed delayed gastric emptying. Carbohydrate energy absorption (mean +/- SD) was, respectively, 86 +/- 5% and 91 +/- 3% in the LAC and the LAC + GP groups (p greater than 0.05). Thus, colonic bacterial fermentation may be critical to energy balance and to the prevention of osmotic diarrhea in premature infants fed lactose.
Kien
C L
CL
Liechty
E A
EA
Myerberg
D Z
DZ
Mullett
M D
MD
D001419:Bacteria / Q000378:metabolism*; D001944:Breath Tests; D003106:Colon / Q000378:metabolism / Q000382:microbiology*; D004040:Dietary Carbohydrates / Q000378:metabolism*; D006801:Humans; D006859:Hydrogen / Q000032:analysis; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D007235:Infant, Premature, Diseases / Q000175:diagnosis; D007408:Intestinal Absorption; D008286:Malabsorption Syndromes / Q000175:diagnosis
D004040:Dietary Carbohydrates; D006859:Hydrogen