Alterations in [3H]desmethylimipramine binding in the aged rat brain: an in vitro autoradiographic demonstration.
Using in vitro autoradiographic receptor binding, the present report provides a descriptive analysis of [3H]desmethylimipramine ([3H]DMI) binding in the aged rat brain. Small circular patches of intense [3H]DMI binding were present within the caudate nucleus in every aged brain examined. Occasionally, similar patches of label were present in restricted cortical regions of aged brains. Comparable patches of [3H]DMI binding were never observed in young brains used in these investigations. Additional evidence suggests that these age-dependent changes in [3H]DMI binding are anatomically restricted to the loci indicated above.
Rapp
P R
PR
University of North Carolina at Chapel Hill, Department of Psychology 27514.
Fanelli
R F
RF
McGuire
M
M
Rosenberg
R A
RA
Gallagher
M
M
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D002421:Caudate Nucleus / Q000254:growth & development / Q000378:metabolism; D003342:Corpus Striatum / Q000254:growth & development / Q000378:metabolism; D003891:Desipramine / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats
D003891:Desipramine