Changes in lung activity of superoxide dismutase and copper concentration during lung tumorigenesis by hydralazine in Swiss mice.
Hydralazine (1-hydrazinophthalazine) was administered in drinking water as a 0.0312% solution to randomly bred Swiss mice for life beginning at 5 weeks of age. The treatments gave rise to statistically significant incidences of lung tumors: 55% in females and 43% in males. A decreased copper concentration and superoxide dismutase activity in the lung of mice were observed. The role of copper and superoxide dismutase in the malignant process is briefly discussed.
Drozdz
M
M
Department of Biochemistry and Chemistry, Silesian Medical School, Katowice, Poland.
Luciak
M
M
Jendryczko
A
A
Magner
K
K
D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens; D003300:Copper / Q000378:metabolism; D006830:Hydralazine / Q000633:toxicity*; D008168:Lung / Q000201:enzymology* / Q000378:metabolism; D008175:Lung Neoplasms / Q000139:chemically induced / Q000201:enzymology* / Q000378:metabolism; D051379:Mice; D012727:Sex Characteristics; D013482:Superoxide Dismutase / Q000378:metabolism*
D002273:Carcinogens; D006830:Hydralazine; D003300:Copper; D013482:Superoxide Dismutase