Endobronchial instillation of epinephrine during cardiopulmonary resuscitation.
We used a standard animal CPR model to study the effectiveness and hemodynamic response of 100 micrograms/kg epinephrine administered endobronchially and to compare the findings after conventional iv administration. Results showed that the endobronchial and iv epinephrine medication improved the survival rate by 100% compared to that of a control group receiving no medication. Although the hemodynamic conditions during cardiac compression were not significantly different after both routes of drug administration, endobronchial instillation produced a prolonged drug action during the first hour of restored spontaneous circulation. A more extensive use of this type of drug administration, especially in out-of-hospital resuscitation, is suggested.
Hörnchen
U
U
Institute of Anesthesiology, University of Bonn, Federal Republic of Germany.
Schüttler
J
J
Stoeckel
H
H
Eichelkraut
W
W
Hahn
N
N
D000818:Animals; D001980:Bronchi; D004837:Epinephrine / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D012151:Resuscitation; D013552:Swine
D004837:Epinephrine