Automation of routine clinical chromosome analysis. I. Karyotyping by machine.
An automated karyotyping system suitable for widespread use in clinical laboratories is described. The software is implemented on a general-purpose, commercially available image analyzer (Magiscan 2) using TV input from a conventional research microscope with minimal modification. The analysis is automatic, but operator interaction is used to resolve difficulties. Extensive experience with a routine clinical workload shows that the system is robust and easy to use and that its use results in a substantially increased laboratory throughput.
Graham
J
J
Wolfson Image Analysis Unit, Department of Medical Biophysics, University of Manchester, England, U.K.
D002875:Chromosomes / Q000032:analysis*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007621:Karyotyping / Q000379:methods