Differential regulation of muscle acetylcholine receptor gamma- and epsilon-subunit mRNAs.
The contents of the mRNAs encoding the gamma- and epsilon-subunits of the nicotinic acetylcholine receptor as well as the single-channel properties of the receptor have been assessed in innervated, denervated and reinnervated rat muscle. The changes in abundance of the gamma- and epsilon-subunit mRNAs correlate with the changes in relative density of two classes of acetylcholine receptor channels. The results support the view that a switch in the relative abundance of the gamma- and epsilon-subunit mRNAs is a major mechanism in regulating the properties of acetylcholine receptor channels in muscle.
Witzemann
V
V
Abteilung Neurochemie, Max-Planck-Institut für biophysikalishe Chemie, Göttingen, FRG.
Barg
B
B
Nishikawa
Y
Y
Sakmann
B
B
Numa
S
S
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003964:Diaphragm / Q000502:physiology; D005786:Gene Expression Regulation; D008969:Molecular Sequence Data; D009121:Muscle Denervation; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011978:Receptors, Nicotinic / Q000235:genetics*
D012333:RNA, Messenger; D011978:Receptors, Nicotinic