Increase in life expectancy for mice fed diethylhydroxylamine (DEHA).
ICR Swiss strain mice were fed diethylhydroxylamine (DEHA) for life starting at 44 days of age at 10, 30, 100, and 300 mg/kg-day. The 10 and 30 mg/kg-day males and the 10 mg/kg-day females showed an increase in mean age of death of 76 (12.7%), 45 (7.5%), and 51 (7.4%) days, respectively, compared to controls. The respective confidence levels are 99.2, 90.0, and 92.9% that these results are significant by Student's t test.
Heicklen
J
J
Department of Chemistry, Pennsylvania State University.
Brown
E
E
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D005260:Female; D006898:Hydroxylamines / Q000494:pharmacology*; D008017:Life Expectancy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009026:Mortality; D011897:Random Allocation; D013268:Stimulation, Chemical; D013934:Thymectomy
D006898:Hydroxylamines; C033314:N,N-diethylhydroxylamine