Induction of synchronized relapses in SJL/J mice with chronic relapsing experimental allergic encephalomyelitis.
Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) was induced in SJL/J mice by two injections of encephalitogenic emulsion. The majority of mice developed multiple relapses from day 22 to day 367 post injection. To induce synchronized relapses a third injection of the encephalitogenic emulsion was given. Almost all mice that received the third injection developed an acute, synchronized relapse with severe clinical signs within 7 to 11 days. Histologically, there was no difference between the lesions in the spontaneous versus the precipitated relapse. CR-EAE in SJL/J mice modified with the third injection offers an advantage of a reproducible and well-timed acute relapse, which allows precise dissection of the immunological events governing spontaneous relapses in chronic EAE.
Kozlowski
P B
PB
New York State Office of Mental Retardation and Developmental Disabilities, Staten Island 10314.
Schuller-Lewis
G B
GB
Wisniewski
H M
HM
D000818:Animals; D000941:Antigens / Q000276:immunology*; D002490:Central Nervous System / Q000473:pathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D051379:Mice; D012008:Recurrence; D013997:Time Factors
D000941:Antigens