Clinical application of thermal isoeffect dose.
Clinically, there is strong rationale for developing a method which will provide a scientific basis for comparing the efficacy of one hyperthermia treatment with another. In order to accomplish this goal, methods must first be developed which will allow the clinician to know the three-dimensional temperature distribution in heated tissue. In this paper, examples of how this goal can be achieved are presented. Techniques for compensating for various modifiers of hyperthermia effectiveness are proposed. The limitations and advantages of these approaches are described and directions for future research are discussed.
Dewhirst
M W
MW
Division of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710.
Winget
J M
JM
Edelstein-Keshet
L
L
Sylvester
J
J
Engler
M
M
Thrall
D E
DE
Page
R L
RL
Oleson
J R
JR
D000818:Animals; D001831:Body Temperature; D004285:Dogs; D006979:Hyperthermia, Induced / Q000379:methods*; D008962:Models, Theoretical; D009374:Neoplasms, Experimental / Q000503:physiopathology / Q000628:therapy; D013817:Thermography