Ectopic prolactin secretion from a gonadoblastoma.
A 6.5-year-old girl developed isosexual, pseudoprecocious puberty secondary to a gonadoblastoma. The tumor was found to produce and secrete both immunoassayable and bioassayable prolactin based on immunohistochemical techniques and the presence of a prolactin gradient between the tumor vein and peripheral vein. The source of the prolactin was a Sertoli-like cell. Neither growth hormone nor growth hormone-releasing hormone was detected within the tumor. This case confirms the ectopic production of prolactin by neoplastic tissue.
Hoffman
W H
WH
Medical College of Georgia, Augusta 30912-3770.
Gala
R R
RR
Kovacs
K
K
Subramanian
M G
MG
D002648:Child; D004407:Dysgerminoma / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006729:Hormones, Ectopic / Q000378:metabolism*; D006801:Humans; D011388:Prolactin / Q000378:metabolism*
D006729:Hormones, Ectopic; D011388:Prolactin; D013006:Growth Hormone