title: Chronic papaverine treatment: the effect of repeated injections on the simian erectile response and penile tissue.
abstract: To investigate the effect of chronic papaverine treatment, seven monkeys underwent repeated intracavernous injections for one year. One monkey died after 56 injections; the others received a total of 100 each. The strength and duration of erection were recorded after each injection, and the erectile tissue was examined histologically at the end of the study. Over the long term, papaverine maintains its erection-inducing capability, but it does cause pathologic changes in the erectile tissue: minimal to marked fibrosis at the injection site and hypertrophy of smooth muscle in the non-injected area of the corpus.
authors: Department of Urology, University of California School of Medicine, San Francisco 94143.
authors: M
authors: M
authors: Abozeid
authors: K P
authors: KP
authors: Juenemann
authors: J A
authors: JA
authors: Luo
authors: T F
authors: TF
authors: Lue
authors: T S
authors: TS
authors: Yen
authors: E A
authors: EA
authors: Tanagho
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005355:Fibrosis; D006984:Hypertrophy / Q000139:chemically induced / Q000473:pathology; D007267:Injections / Q000379:methods; D008099:Liver / Q000187:drug effects; D008252:Macaca fascicularis; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000648:ultrastructure; D010208:Papaverine / Q000494:pharmacology*; D010410:Penile Erection / Q000187:drug effects*; D010413:Penis / Q000187:drug effects* / Q000648:ultrastructure; D013997:Time Factors
chemical_list: D010208:Papaverine