The deafferentation syndrome in the rat: effects of intraventricular neurotensin and cholecystokinin.
A deafferentation syndrome can be produced in rats by dorsal root ganglionectomies. This syndrome consists of scratching and/or biting of the anesthetic limb to the point of amputation. This behavior may serve as an experimental model to study certain aspects of chronic dysesthesias and/or pain caused by deafferentation in man. In this study, we made behavioral observations on the deafferentation syndrome and examined the possibility that intraventricular neurotensin and cholecystokinin alter the course of this syndrome. We found that neurotensin accelerated the scratching component without affecting the biting behavior. Cholecystokinin, however, attenuated the release of both components of the syndrome.
Rossitch
E
E
Department of Surgery, Duke University Medical Center Durham, North Carolina 27710.
Ovelmen-Levitt
J
J
Lyerly
M A
MA
Nashold
B S
BS
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002552:Cerebral Ventricles / Q000502:physiology*; D002766:Cholecystokinin / Q000494:pharmacology*; D005260:Female; D005727:Ganglia, Spinal; D007276:Injections, Intraventricular; D009422:Nervous System Diseases / Q000209:etiology / Q000523:psychology*; D009496:Neurotensin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013562:Sympathectomy
D009496:Neurotensin; D002766:Cholecystokinin