[Pharmacological research on ophthalmic drug lamellae containing gentamycin sulfate in laboratory and agricultural animals].
The in vitro and in vivo solubility of ocular drug lamellae, containing 1.5 and 3 mg gentamycin sulphate, was followed up. It was found that those that contained lower amount of the antibiotic disintegrated in the eyes of rabbits, lambs, and sheep for 30-40 minutes, while lamellae having 3 mg gentamycin disintegrated for 45-50 minutes. It is stated that such ocular lamellae are well tolerated by the conjunctiva of the animal species referred to. With the application of one lamella with 3 mg gentamycin sulphate therapeutic concentrations of the antibiotic in the lacrimal secretion are found up to the 24 th hour with cows, sheep, and lambs, and up to the 48h hour with rabbits.
Vangelov
S
S
Tashev
L
L
Hidalgo
J
J
D000287:Administration, Topical; D000818:Animals; D002417:Cattle; D003228:Conjunctiva; D003692:Delayed-Action Preparations; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D011817:Rabbits; D012756:Sheep; D012995:Solubility; D013666:Tears / Q000378:metabolism; D013997:Time Factors
D003692:Delayed-Action Preparations; D005839:Gentamicins
Niakoi farmakologichni izsledvaniia vŭrkhu ochni lekarstveni lameli, sŭdŭrzhashti gentamitsinov sulfat, pri laboratorni i selskostopanski zhivotni.