Studies on annelated 1,4-benzothiazines and 1,5-benzothiazepines. III--Synthesis and CNS activity of some 1-substituted derivatives of the novel heterocyclic system 4,5-dihydro-s-triazolo [3,4-d]-1,5-benzothiazepine.
A series of new 4,5-dihydro-s-triazolo [3,4-d]-1,5-benzothiazepines has been prepared. All the described compounds are representative of a novel ring system. Some of these compounds were tested for their CNS activity and effects comparable with the ones of diazepam were observed.
Ambrogi
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V
Istituto di Chimica Farmaceutica e Tecnica Farmaceutica, Università di Perugia, Italy.
Grandolini
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G
Rossi
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C
Tiralti
M C
MC
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D002492:Central Nervous System Depressants / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004347:Drug Interactions; D006591:Hexobarbital / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D012890:Sleep / Q000187:drug effects; D013841:Thiazepines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D014149:Tranquilizing Agents / Q000138:chemical synthesis
D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D013841:Thiazepines; D013843:Thiazines; D014149:Tranquilizing Agents; D006591:Hexobarbital; D010433:Pentylenetetrazole