Structure of a novel Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase inhibitor K-259-2.
The structure of K-259-2, a potent inhibitor of Ca2+ and calmodulin-dependent cyclic nucleotide phosphodiesterase, was determined to be 3-(2Z-2-ethyl-2-butenyl)-1,6,8-trihydroxy-anthraquinone-2-carboxyl ic acid by chemical conversion and spectral studies.
Yasuzawa
T
T
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
Yoshida
M
M
Shirahata
K
K
Sano
H
H
D009682:Magnetic Resonance Spectroscopy; D008847:Micromonospora / Q000032:analysis; D010726:Phosphodiesterase Inhibitors; D013057:Spectrum Analysis
D010726:Phosphodiesterase Inhibitors