title: Stability of sevoflurane in soda lime.
abstract: Stability of halogenated volatile anesthetic is important because of the potential toxicity associated with the breakdown products. The authors enclosed 100 ml of gas containing sevoflurane with 100 g of soda lime in a 581-ml flask for periods up to 24 h. The rate of degradation of sevoflurane by soda lime was several-fold greater than previously reported, and the degradation was temperature-dependent. At 22 degrees C, soda lime degraded 6.5% of the sevoflurane per hour. The rate increased by 1.6% per hour per degree rise in temperature, reaching 57.4% degradation per hour at 54 degrees C. In contrast, isoflurane was not degraded by soda lime. Halothane did not degrade at 22 degrees C or 37 degrees C, but did degrade (2.2% per hour) at 54 degrees C.
authors: Department of Anesthesia, University of California, San Francisco 94143.
authors: D P
authors: DP
authors: Strum
authors: B H
authors: BH
authors: Johnson
authors: E I
authors: EI
authors: Eger
mesh_terms: D000777:Anesthetics; D017610:Calcium Compounds; D004355:Drug Stability; D004987:Ethers; D006221:Halothane; D007530:Isoflurane; D008738:Methyl Ethers; D010087:Oxides; D000077149:Sevoflurane; D012972:Sodium Hydroxide
chemical_list: D000777:Anesthetics; D017610:Calcium Compounds; D004987:Ethers; D008738:Methyl Ethers; D010087:Oxides; D000077149:Sevoflurane; C004569:soda lime; D012972:Sodium Hydroxide; D007530:Isoflurane; D006221:Halothane