Comparison of potential cytoprotective action of sucralfate and cimetidine. Studies with experimental feline esophagitis.
The potential mucosal protective effects of a liquid sucralfate preparation and the histamine (H2)-antagonist cimetidine on acid-induced esophagitis were studied. Esophagitis was induced in adult cats using a constant infusion of 0.1 N hydrochloric acid at 1 ml/minute for 20 minutes. Mucosal lesions were evaluated by blinded investigators using both fiber-optic endoscopy and light microscopy. Histology was scored for basal cell hyperplasia, intraepithelial leukocytosis, and subepithelial leukocytosis. Liquid sucralfate given prior to acid infusion consistently prevented acid-induced lesions, demonstrated by quantitative histologic scoring. Although cimetidine did not show the same degree of protection as sucralfate, the results did show a trend towards a cytoprotective effect.
Clark
S
S
Department of Medicine, Bowman Gray School of Medicine, Wake Forest University Medical Center, Winston-Salem, North Carolina.
Katz
P O
PO
Wu
W C
WC
Geisinger
K R
KR
Castell
D O
DO
D000818:Animals; D002415:Cats; D002927:Cimetidine / Q000627:therapeutic use*; D004724:Endoscopy; D004848:Epithelium / Q000473:pathology; D004941:Esophagitis / Q000473:pathology / Q000517:prevention & control*; D004947:Esophagus / Q000187:drug effects; D005336:Fiber Optic Technology; D006965:Hyperplasia / Q000473:pathology; D007964:Leukocytosis / Q000473:pathology; D009092:Mucous Membrane / Q000187:drug effects; D055100:Optical Fibers; D013392:Sucralfate / Q000627:therapeutic use*
D013392:Sucralfate; D002927:Cimetidine