title: Mutagenicity of instant coffee and its interaction with dimethylnitrosamine in the micronucleus test.
abstract: The mutagenicity of instant coffee and its interaction with dimethylnitrosamine (DMN) were examined in mice using the micronucleus test. Although neither a single nor multiple administration of instant coffee by gavage induced a significant rise in micronucleated cells over the dose range tested (100-2500 mg/kg), there was a tendency for the number of micronucleated cells to increase in a dose-related fashion. When coffee was administered with DMN, the difference in the frequency of micronucleated cells was small in comparison to a single treatment with DMN alone, thus indicating a lack of synergism between coffee and DMN.
authors: Department of Environmental Health, Faculty of Health Sciences, University of Kyorin, Japan.
authors: M
authors: M
authors: Shimizu
authors: E
authors: E
authors: Yano
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002467:Cell Nucleus / Q000187:drug effects* / Q000648:ultrastructure; D003069:Coffee; D004128:Dimethylnitrosamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008658:Inactivation, Metabolic; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D009152:Mutagenicity Tests
chemical_list: D003069:Coffee; D004128:Dimethylnitrosamine