Studies in the field of pyridazine compounds. Part 21. Structural studies on 6-H-pyrimido[1,2-b]-1,2,4-triazolopyridazines.
The structure of 7,8-dihydro-6H-pyrimido [1,2-b]-1,2,4-triazolo [3,4-f] pyridazine (2a) was confirmed by 1H and 13C NMR spectroscopy and by preparation of the isomeric [5,1-f] pyridazine 3. Some derivatives of 6H-pyrimido [1,2-b]-1,2,4,-triazolo [3,4-f]pyridazine were prepared. Compounds 2a, 2b and 9a showed a positive inotropic effect.
Kosary
J
J
Institute for Drug Research, Budapest, Hungary.
Polos
K
K
Kasztreiner
E
E
D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009682:Magnetic Resonance Spectroscopy; D011724:Pyridazines / Q000138:chemical synthesis*; D011744:Pyrimidinones / Q000138:chemical synthesis*; D014230:Triazoles / Q000138:chemical synthesis*
D002316:Cardiotonic Agents; D011724:Pyridazines; D011744:Pyrimidinones; D014230:Triazoles