[Increased enzymatic activity of antioxidant protection of the heart in the adaptation of rats to short-term stress exposure].
It has been shown that adaptation to short-term emotional-painful stresses leads to an increase in antioxidant enzyme activities but does not change vitamin E content in the myocardium. The most labile enzyme was catalase (35% increase). During stress in nonadapted animals the enzyme activity decreased, as compared to the control, while in the group of adapted animals with subsequent stress the activity was even higher than in the control. During initiation of lipid peroxidation in the heart homogenates in vitro there was a 3-fold increase and a 1%-fold decrease in the oxidation intensity in rats exposed to stress and in adapted animals, respectively. The role of adaptation activation of cardiac antioxidant system in the prevention of stress-induced heart damage is discussed.
Sazontova
T G
TG
Arkhipenko
Iu V
IuV
Meerson
F Z
FZ
D000222:Adaptation, Physiological; D000818:Animals; D002374:Catalase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006321:Heart / Q000503:physiopathology*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000201:enzymology* / Q000503:physiopathology; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors; D014810:Vitamin E / Q000378:metabolism
D014810:Vitamin E; D010088:Oxidoreductases; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
Uvelichenie aktivnosti fermentov antioksidantnoĭ zashchity serdtsa pri adaptatsii krys k korotkim stressovym vozdeĭstviiam.