title: Evidence of "cross-stressor"-induced adaptive gastric cytoprotection.
abstract: Rats were given 7 days pre-treatment with either water (p.o.), 1 h immobilization or 20% ethanol (p.o.) with or without concomitant indomethacin injection. Following the pre-treatment phase, rats from each pre-treatment group were exposed to either 3 h cold-restraint stress or to 100% ethanol p.o. Results indicated that immobilization and 20% ethanol pre-treatment significantly reduced both cold-restraint stress ulcer formation and 100% ethanol-induced ulcers. Indomethacin co-treatment attenuated the reduction of ulcer formation of both pretreatments. These results suggest that "cross-stressor" adaptive cytoprotection occurs. Indomethacin abolished these effects, implicating the involvement of endogenous prostaglandins in the mediation of "cross-stressor"-induced gastric cytoprotection.
authors: Dept. Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
authors: G B
authors: GB
authors: Glavin
authors: L K
authors: LK
authors: Lockhart
authors: G E
authors: GE
authors: Rockman
authors: A M
authors: AM
authors: Hall
authors: K M
authors: KM
authors: Kiernan
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D003080:Cold Temperature; D000431:Ethanol / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology; D013312:Stress, Physiological / Q000150:complications* / Q000503:physiopathology
chemical_list: D000431:Ethanol; D007213:Indomethacin