Tolerance to diazepam-induced avoidance depression in mice.
The disrupting action on avoidance responses, exerted by diazepam given during shuttle-box training (5 mg/kg before each session), was abolished by a pretreatment with the drug (5 mg/kg) for five days. Similarly, avoidance depression, produced by diazepam in trained mice, was prevented by a pretreatment with five daily doses and was attenuated by previous administration of three daily injections or even of a single dose of the drug. The results demonstrate that tolerance rapidly develops to diazepam-induced avoidance depression, as to other behavioral actions of benzodiazepines.
Sansone
M
M
Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy.
Renzi
P
P
Vetulani
J
J
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology*; D004361:Drug Tolerance; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA
D003975:Diazepam