title: Effect of omeprazole on gastric acid secretion in rat: evaluation of dose, duration of effect, and route of administration.
abstract: The effect of omeprazole on gastric acid output was studied in rats before and during stimulation by continuous administration of tetragastrin at 50 micrograms/kg-hour. From 5 to 20 mg/kg of omeprazole was given to animals intraperitoneally, perorally and intravenously from 2 to 24 hours before the gastric secretory study was started, and the respective effects on acid secretion were compared. In each administration group, 20 mg/kg of omeprazole was the most potent among the groups receiving 5, 10 or 20 mg/kg, when the drug was given 2 hours before the study. There were statistically significant differences between the control group given tetragastrin only and each of the groups given 20 mg/kg of omeprazole perorally, intraperitoneally and intravenously. There was no significant difference among the groups given 20 mg/kg of omeprazole intraperitoneally, intravenously and perorally. The effect of 20 mg/kg of omeprazole continued at least 24 hours after the agent was administered perorally.
authors: Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
authors: K
authors: K
authors: Segawa
authors: S
authors: S
authors: Nakazawa
authors: Y
authors: Y
authors: Tsukamoto
authors: C
authors: C
authors: Chujoh
authors: K
authors: K
authors: Yamao
authors: S
authors: S
authors: Hase
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013758:Tetragastrin / Q000494:pharmacology
chemical_list: D013758:Tetragastrin; D009853:Omeprazole