[Specific acid-soluble chromatin protein synthesized in the rat liver after cortisone administration].
After cortisone injection, the content of the specific chromatin acid-soluble non-histone protein alpha is markedly increased in rat liver cells. The alpha-protein has been isolated in preparative amounts, its amino acid composition and some properties have been studied. It has been shown that the amino acid composition of protein alpha differs markedly from that of the HMG proteins, semi-histone A24, and of other non-histone proteins studied so far. Cortisone has been shown to induce the de novo synthesis of protein alpha. The alpha-protein is observed in transcriptionally active chromatin. The 3H-labeled hydrocortisone and dexamethasone bind mainly to this protein. The suggestion, that this protein participates in the regulation of transcriptional activity of liver cells in response to the hormonal stimulus is put forward.
Turoverova
L V
LV
Konstantinova
I M
IM
Iakovleva
M F
MF
Vorob'ev
V I
VI
D000596:Amino Acids; D000818:Animals; D002843:Chromatin / Q000032:analysis*; D002868:Chromosomal Proteins, Non-Histone / Q000032:analysis / Q000096:biosynthesis*; D003348:Cortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D003348:Cortisone
Issledovanie spetsificheskogo kislotorastvorimogo belka khromatina, sinteziruiushchegosia v kletkakh pecheni krysy posle vvedeniia kortizona.