Isolation and hypoglycemic activity of quinquefolans A, B, and C, glycans of Panax quinquefolium roots.
An H2O extract of the American crude drug "Amerika-ninjin" (American ginseng), Panax quinquefolium roots, exhibited significant hypoglycemic activity in mice. Activity-guided fractionation of the extract led to isolation of three glycans, quinquefolans A, B, and C, which displayed hypoglycemic effects in normal and alloxan-induced hyperglycemic mice.
Oshima
Y
Y
Pharmaceutical Institute, Tohoku University, Sendai, Japan.
Sato
K
K
Hikino
H
H
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004590:Electrophoresis, Paper; D004591:Electrophoresis, Polyacrylamide Gel; D007004:Hypoglycemic Agents / Q000302:isolation & purification*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D005894:Panax / Q000032:analysis*; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology; D010946:Plants, Medicinal; D011134:Polysaccharides / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology
D007004:Hypoglycemic Agents; D010936:Plant Extracts; D011134:Polysaccharides; C053589:quinquefolan A; C053590:quinquefolan B; C053591:quinquefolan C