[Effect of the delta sleep peptide on epileptic activity in the cerebral cortex of rats and cats].
In free behaviour experiments on rats it has been shown that the intraperitoneal injection of delta sleep-inducing peptide (DSIP) (100 micrograms/kg) suppressed penicillin-induced relatively moderate epileptic foci which generated spike potentials as well as severe foci with ictal epileptic discharges. In the experiments on cats it was shown that intravenous DSIP injection (100 micrograms/kg) suppressed strychnine-induced epileptic focus and complexes of epileptic foci.
Kryzhanovskiĭ
G N
GN
Shandra
A A
AA
Godlevskiĭ
L S
LS
Karpova
M N
MN
Mikhaleva
I I
II
D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects*; D003701:Delta Sleep-Inducing Peptide / Q000627:therapeutic use*; D004827:Epilepsy / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D010406:Penicillins / Q000037:antagonists & inhibitors; D051381:Rats; D013331:Strychnine / Q000037:antagonists & inhibitors*
D010406:Penicillins; D003701:Delta Sleep-Inducing Peptide; D013331:Strychnine
Vliianie peptida del'ta-sna na épilepticheskuiu aktivnost' v kore bol'shogo mozga krys i koshek.