title: Bioavailability and disposition of metoclopramide after single- and multiple-dose administration in diabetic patients with gastroparesis.
abstract: The disposition of metoclopramide after acute and chronic administration was determined in four diabetic patients with gastroparesis who had a creatinine clearance of 70.8 +/- 10.7 mL/min (mean +/- SD). Single, 10-mg oral and intravenous doses were administered on days 1 and 2, respectively, followed by 10 mg orally every six hours for three weeks. A second, 10-mg intravenous bolus dose was administered on the last morning of chronic therapy. Metoclopramide concentrations were determined by high performance liquid chromatography. The elimination half-life, steady-state volume of distribution, and total body clearance after the initial intravenous dose were 3.9 +/- 1.2 hr, 2.7 +/- 0.3 L/kg, and 0.57 +/- 0.14 L/hr/kg, respectively. The initial bioavailability was 67.7 +/- 12.6%. After three weeks of chronic therapy, no significant differences in total body clearance (0.72 +/- 0.42 L/hr/kg) or bioavailability (77.5 +/- 16.8%) were observed. Thus the pharmacokinetics and bioavailability of metoclopramide were not altered during chronic therapy in these diabetic patients.
authors: Department of Medicine, Hennepin County Medical Center, Minneapolis, MN 55415.
authors: M E
authors: ME
authors: O'Connell
authors: W M
authors: WM
authors: Awni
authors: M
authors: M
authors: Goodman
authors: O
authors: O
authors: Cass
authors: A P
authors: AP
authors: Melikian
authors: G J
authors: GJ
authors: Wright
authors: G R
authors: GR
authors: Matzke
mesh_terms: D000328:Adult; D001682:Biological Availability; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008875:Middle Aged
chemical_list: D008787:Metoclopramide