[Antibacterial activity of chlorquinaldol esters and 2-styryl-substituted derivatives].
Studied was the bacteriostatic activity of a total of 17 new esters and replaced 2-styryl derivatives of chlorquinaldol. Determined were also the lowest concentrations that suppressed the growth of organisms. Some of the compounds showed higher activity and broader spectrum of antibacterial qualities, mainly against Escherichia coli, Salmonella gallinarum, and Salmonella cholerae suis as compared to the initial therapeutic preparation chlorquinaldol. It was found that the presence of chlorine atoms either in the second or in the second and fourth place in the benzene nucleus of the esters studied, the presence of a NO2-group in the third place of the same nucleus, and the presence of an extranuclear hydroxyacetyl remainder in the ester grouping could lead to a rise of the antibacterial activity. The presence of an F atom in the second and third place of the benzene nucleus of the sterile grouping also raised the activity of these compounds.
Kolev
K K
KK
Vŭrbanova
S
S
Chervenkov
S
S
Pavlov
A
A
D001419:Bacteria / Q000187:drug effects*; D002750:Chlorquinaldol / Q000031:analogs & derivatives / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006912:Hydroxyquinolines / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D006912:Hydroxyquinolines; D002750:Chlorquinaldol
Izsledvane na antibakteriĭnata aktivnost na niakoi esteri i zamesteni 2-stirilni proizvodni na khlorkhinaldola.