title: Simultaneous determination of regional cerebral blood flow, glucose metabolism, and pH in acute experimental allergic encephalomyelitis.
abstract: Regional cerebral blood flow (rCBF), regional cerebral glucose metabolic rate (rCMR), and regional pH (r-pH) were measured simultaneously in fulminant acute experimental allergic encephalomyelitis (EAE) by the use of triple-label autoradiography. No changes were found in the absence of lesions (lymphocytic accumulations). In the lesions, rCBF was 79% increased and rCRM was 13% increased, whereas r-pH was unaltered compared to normal values. The reported changes result in a CBF/CMR ratio of almost 3 in the lesions compared to the normal value of 1.5. The changes may be interpreted as primary disturbances in glucose metabolism, resulting in a secondary increase in CBF. This theory is supported by quoted observations on abnormal morphology and abnormal enzyme content in brain mitochondria in EAE.
authors: University Clinic of Neurology, Rigshospitalet, Copenhagen, Denmark.
authors: M
authors: M
authors: Juhler
mesh_terms: D000208:Acute Disease; D000818:Animals; D001345:Autoradiography / Q000379:methods; D002560:Cerebrovascular Circulation; D004679:Encephalomyelitis / Q000378:metabolism / Q000503:physiopathology*; D005947:Glucose / Q000378:metabolism*; D006168:Guinea Pigs; D006859:Hydrogen / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration
chemical_list: D006859:Hydrogen; D005947:Glucose