title: Calorie restriction modifies the delayed-type hypersensitivity response to the hapten trinitrobenzenesulfonic acid and to hapten-modified syngeneic spleen cells.
abstract: We have studied the influence of different degrees of calorie restriction on the induction and the regulation of the delayed type hypersensitivity (DTH) response to trinitrobenzenesulfonic acid (TNBS) and TNBS-modified spleen cells (TNBS-SC), injected by the sc or the iv route. Immediately after weaning, BALB/c mice were placed on restricted diets for either 2 or 4 weeks and then the DTH response was induced. The results showed that a 37.5% restriction in the food supply significantly depressed the level of the DTH response induced by the sc injection of TNBS-SC. In contrast, a 25% restriction in the food supply was insufficient to depress the response. Calorie restriction did not modify the inhibitory influence of an iv injection of TNBS-SC on the DTH response. However, iv presensitization with free hapten or the simultaneous injection of TNBS-SC by the iv and the sc routes did not significantly depress the DTH response in calorie-restricted mice, indicating a defect in the inhibitory regulation of the DTH response in these dietary groups.
authors: Department of Experimental Medicine, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
authors: M
authors: M
authors: Pocino
authors: L
authors: L
authors: Baute
authors: I
authors: I
authors: Malavé
mesh_terms: D000818:Animals; D001835:Body Weight; D004038:Diet, Reducing; D005260:Female; D006241:Haptens; D006968:Hypersensitivity, Delayed; D007114:Immunization; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009578:Nitrobenzenes; D013154:Spleen / Q000276:immunology; D013997:Time Factors; D014302:Trinitrobenzenesulfonic Acid
chemical_list: D006241:Haptens; D009578:Nitrobenzenes; D014302:Trinitrobenzenesulfonic Acid