[The role of cell membrane damage in the development of hormone-resistant kidney diseases in children].
Distinct increase in content of lysophosphatidyl choline, dehydrocholesterol, decrease in concentration of phosphatidyl ethanolamine simultaneously with high level of diene conjugates and Schiff bases were found in children with hormone-resistant form of nephrotic glomerulonephritis as compared with children suffering from a hormone-dependent form of the disease. Peroxidation of membrane lipids appears to cause a destabilization of cell membranes, which is responsible for development of hormone-resistance.
Krylov
V I
VI
Petrushina
A D
AD
Moreva
G V
GV
Grannik
G K
GK
Durygin
A N
AN
D002648:Child; D004351:Drug Resistance; D004907:Erythrocyte Deformability; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005921:Glomerulonephritis / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D005938:Glucocorticoids / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008563:Membrane Lipids / Q000097:blood*; D010743:Phospholipids / Q000097:blood
D005938:Glucocorticoids; D008054:Lipid Peroxides; D008563:Membrane Lipids; D010743:Phospholipids
Rol' narusheniĭ struktury kletochnykh membran v formirovanii gormonorezistentnykh variantov zabolevaniĭ pochek u deteĭ.