[Dependency on sex hormone in human esophageal cancer--measurement of the androgen receptor in resected specimens].
Clinically it is well known that the incidence of esophageal cancer is much higher in men that in women. Further, the prognosis of the esophageal cancer is worse for men than for women. This seems to be dependent on the difference of environment of the sex steroid. In this paper, the androgen receptor (AR) has been measured in 21 cases of human esophageal cancer. Two cases of esophageal cancer that were implanted into nude mice were AR positive. In this EH-1 cell line, the binding sites were increased and the tumor growth was enhanced by testosterone administration, but the tumor growth was not inhibited by estrogen administration.
Yamashita
Y
Y
Dept. of Surgery, Hiroshima Univ.
Hirai
T
T
Miyoshi
Y
Y
Ohtagaki
S
S
Mukaida
H
H
Toge
T
T
Niimoto
M
M
Hattori
T
T
D000368:Aged; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000032:analysis* / Q000473:pathology / Q000601:surgery; D004938:Esophageal Neoplasms / Q000032:analysis* / Q000473:pathology / Q000601:surgery; D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation; D009376:Neoplasms, Hormone-Dependent / Q000032:analysis*; D011944:Receptors, Androgen / Q000032:analysis*
D012739:Gonadal Steroid Hormones; D011944:Receptors, Androgen