[Eremomycin--a new antibiotic from the cyclic glycopeptide group].
Eremomycin, a novel antibiotic belonging to the group of cyclic glycopeptides is produced by an actinomycete designated INA-238. Biosynthesis, isolation, physico-chemical and biological properties of the antibiotic are described. Eremomycin is shown to be close to vancomycin. However, by its chromatographic and electrophoretic mobility, presence of chlorine in the antibiotic molecule and optic characteristics eremomycin differs from vancomycin. Eremomycin is less toxic than vancomycin whereas its chemotherapeutic activity in treatment of infections caused by gram-positive organisms is higher.
Gauze
G F
GF
Brazhnikova
M G
MG
Laĭko
A V
AV
Sveshnikova
M A
MA
Preobrazhenskaia
T P
TP
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D051379:Mice; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D013329:Structure-Activity Relationship; D014640:Vancomycin / Q000032:analysis / Q000494:pharmacology / Q000633:toxicity
D000900:Anti-Bacterial Agents; D014640:Vancomycin
Eremomitsin--novyĭ antibiotik iz gruppy tsiklicheskikh glikopeptidov.