Novel chiral stationary phases for optical resolution by ligand-exchange high-performance liquid chromatography.
Novel chiral stationary phases, (1R,2S)- and diastereomeric (1S,2S)-2-carboxymethylamino-1,2-diphenylethanol, were prepared from (1R,2S)- and (1S,2S)-2-amino-1,2-diphenylethanol, respectively, and were bound to silica gel pretreated with 3-glycidoxypropyltrimethoxysilane. The chiral stationary phases were found to be very effective for the optical resolution of amino acids, amino acid derivatives and hydroxy acids by ligand-exchange high-performance liquid chromatography.
Yuki
Y
Y
Research Centre, Daicel Chemical Industries Ltd., Hyogo, Japan.
Saigo
K
K
Kimoto
H
H
Tachibana
K
K
Hasegawa
M
M
D000596:Amino Acids / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D008024:Ligands; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism
D000596:Amino Acids; D008024:Ligands