Thiazide diuretics for the treatment of children with idiopathic hypercalciuria and hematuria.
We describe our experience in 14 children with idiopathic hypercalciuria and hematuria who received a finite course of thiazide diuretics. Thiazides reduced urinary calcium excretion and resolved hematuria in all cases. Serum calcium concentration was not altered with treatment. Serum potassium concentration decreased, and total carbon dioxide content and uric acid concentrations increased in response to therapy but these changes did not necessitate discontinuation of treatment. Thiazides were discontinued electively after 16 +/- 15 months of treatment (range 3 to 40 months). Six children maintained normal urinary calcium excretion, while 8 displayed excessive calcium excretion for 16 +/- 4 months after treatment was stopped. Renal calculi were not detected in any patient during this interval but hematuria recurred in 4 children. These findings suggest that thiazides are safe and effective for resolving hypercalciuria and hematuria. Thiazides may be discontinued safely in some children, while others will require further treatment courses or prolonged continuous therapy.
Hymes
L C
LC
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
Warshaw
B L
BL
D001581:Benzothiadiazines; D002118:Calcium / Q000652:urine*; D002648:Child; D004232:Diuretics; D004341:Drug Evaluation; D006417:Hematuria / Q000188:drug therapy* / Q000209:etiology / Q000652:urine; D006801:Humans; D007669:Kidney Calculi / Q000150:complications / Q000188:drug therapy / Q000652:urine; D012008:Recurrence; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use*; D013997:Time Factors
D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D002118:Calcium