title: Sympathetic ophthalmia complicating helium ion irradiation of a choroidal melanoma.
abstract: Sympathetic ophthalmia was diagnosed 49 months after helium ion irradiation of a left choroidal melanoma. The patient maintained good vision until 18 months after therapy, when she developed neovascular glaucoma. This complication required multiple therapeutic procedures, including topical anti-inflammatory and antiglaucomatous drops, 360 degrees peripheral panretinal cryoblation, and a single 180 degrees application of inferior cyclocryotherapy over a 2 1/2-year period. Four weeks after the cyclocryotherapy, inflammation was noted in both eyes, and, one month later, enucleation of the left sympathogenic eye was performed. Serial histopathologic sections showed a full-thickness, fibrovascular, scleral scar and tantalum marker ring suture without uveal incarceration. Penetrating surgical trauma, a uveal melanoma, and multiple nonpenetrating treatments resulted in the development of sympathetic ophthalmia.
authors: Department of Ophthalmology, University of California, San Francisco 94143.
authors: P D
authors: PD
authors: Fries
authors: D H
authors: DH
authors: Char
authors: J B
authors: JB
authors: Crawford
authors: W
authors: W
authors: Waterhouse
mesh_terms: D000368:Aged; D002830:Choroid Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005654:Fundus Oculi; D006371:Helium / Q000627:therapeutic use*; D006801:Humans; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy*; D009879:Ophthalmia, Sympathetic / Q000209:etiology* / Q000473:pathology; D011832:Radiation Injuries / Q000150:complications*
chemical_list: D006371:Helium