Functional drug targeting to erythrocytes in vivo using antibody bearing liposomes as drug vehicles.
Covalent attachment of anti-erythrocyte F(ab')2 to the liposome surface has recently been shown to considerably enhance the liposome binding to erythrocytes in vivo. These antibody bearing liposomes have now been found quite effective as vehicles for delivering the antimalarial drug, chloroquine, to erythrocytes in Plasmodium berghei-infected mice. This demonstrates the usefulness of antibody targeted liposomes as carriers for site-specific drug delivery.
Agrawal
A K
AK
Division of Membrane Biology, Central Drug Research Institute, Lucknow, India.
Singhal
A
A
Gupta
C M
CM
D000818:Animals; D002738:Chloroquine / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005732:Gangliosides / Q000097:blood; D007140:Immunoglobulin Fab Fragments; D008051:Lipid Bilayers / Q000008:administration & dosage; D008081:Liposomes / Q000008:administration & dosage*; D008288:Malaria / Q000097:blood* / Q000188:drug therapy; D008297:Male; D051379:Mice; D010713:Phosphatidylcholines / Q000097:blood
D005732:Gangliosides; D007140:Immunoglobulin Fab Fragments; D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines; D002738:Chloroquine; D002784:Cholesterol