Electrophysiological study of the peripheral and central neurotoxic effect of cis-platin.
We describe clinical and electrophysiological findings in 8 patients with tumors of germ cell origin before and after treatment with high-dose cisplatin (800-1400 mg) combined with etoposide and bleomycin. All patients developed clinical or electrophysiological signs, or both, of a peripheral sensory neuropathy. One had in addition clinical and electrophysiological signs of CNS involvement, and 2 had a central conduction defect revealed by auditory stimulation.
Daugaard
G K
GK
Department of Oncology, Finsen Institute, Copenhagen, Denmark.
Petrera
J
J
Trojaborg
W
W
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000187:drug effects*; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D012684:Sensory Thresholds; D013736:Testicular Neoplasms / Q000188:drug therapy*; D014110:Touch / Q000187:drug effects
D002945:Cisplatin