title: Thermochemistry of aqueous solutions of alkylated nucleic acid bases. VI. Enthalpies of hydration of 2-alkyl-9-methyladenines.
abstract: Enthalpies of solution in water, delta H0sol, and vant'Hoff enthalpies of sublimation, delta H0subl, were determined experimentally for a number of crystalline 2-alkyl derivatives of 9-methyladenine: m2(2,9)Ade, e2m9Ade, pr2m9Ade and but2m9Ade. Standard enthalpies of hydration, delta H0hydr derived from these data were corrected for the calculated cavity terms, delta H0cav, to yield enthalpies of interaction, delta H0int, of the solutes with their hydration shells. The apparent residual contribution of alkyl groups, R, to the enthalpy of interaction delta delta H0int (R) was found to increase linearly with the number of CH2 groups added upon alkyl substitution, whereas this contribution calculated per unit area of the water-accessible molecular surface, SB, of alkyl residues delta delta H0int (R): delta SB(R) appeared constant over the whole series of the compounds investigated. This indicates that alkyl groups substituted at the C(2) carbon atom of the adenine contribute additively to the van der Waals' part of the enthalpy of interaction and do not affect the electrostatic part of the energy of interaction of the solutes with their hydration shells.
authors: Institute of Physical Chemistry, Polish Academy of Sciences, Warszawa.
authors: A
authors: A
authors: Zielenkiewicz
authors: W
authors: W
authors: Zielenkiewicz
authors: L F
authors: LF
authors: Sukhodub
authors: O T
authors: OT
authors: Glukhova
authors: K L
authors: KL
authors: Wierzchowski
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives*; D000478:Alkylation; D008968:Molecular Conformation; D013816:Thermodynamics; D014867:Water
chemical_list: D014867:Water; C013115:9-methyladenine; D000225:Adenine