[Mechanism of self-regulation and the inotropic reaction of the rat myocardium during aging].
The experiments on rat papillary muscles revealed that in ageing rats myocardium has a decreased distension ability. The curves of shortening value/length and force/velocity for the myocardium of old animals are shifted downwards. The alterations in isotonic contraction parameters had a distinct age differentiation, while the age did not affect the inotropic effects of increased frequency, paired stimulation and external calcium. It is suggested that changes in biomechanical properties of ageing myocardium are associated with alterations in calcium transport in sarcoplasmic reticulum.
Lobanok
L M
LM
Sineleva
M V
MV
D000375:Aging / Q000502:physiology*; D000818:Animals; D066298:In Vitro Techniques; D009200:Myocardial Contraction; D051381:Rats
Mekhanizm samoreguliatsii i inotropnaia reaktsiia miokarda krys pri starenii.