[Demonstration of a correlation between the degree of pigmentation and the power of inactivation of isoniazid in man].
In a group of 153 white subjects treated for tubercle, individual determinations were made of: a) The power of inactivation of isoniazid. b) The degree of pigmentation (iris, skin, hair) assessed by a weighted pigmented index of the iris. A statistical study of the results shows the clear existence of a narrow positive correlation between these two characters, such that the more pigmented a subject is, the greater is the chance of rapid inactivation of isoniazid. An attempt at a biochemical explanation is proposed. The results in the world literature (Japanese, Swedish, American) are in keeping with these observations. Thus, weakly pigmented tuberculous patients are potentially a new group at risk from anti-TB drugs.
Vivien
J N
JN
Centre Edouard-Rist, Paris.
Leperchey
F
F
Vicaut
E
E
Deplus
S
S
Gervais
P
P
D005127:Eye Color; D006197:Hair; D006801:Humans; D007498:Iris / Q000503:physiopathology; D007538:Isoniazid / Q000378:metabolism / Q000627:therapeutic use*; D010858:Pigmentation; D012880:Skin Pigmentation; D014376:Tuberculosis / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology
D007538:Isoniazid
Mise en évidence d'une corrélation entre le degré de pigmentation et la puissance d'inactivation de l'isoniazide chez l'homme.