The regional cerebral blood flow in patients under chronic hemodialytic treatment.
Regional cerebral blood flow (rCBF) was measured by the xenon-133 inhalation method in an unselected group of nine chronic hemodialysis patients before and after a single hemodialytic treatment. All patients underwent neurological, neuropsychological, and biochemical evaluations on the same occasions. Predialysis rCBF values did not differ from those obtained in age-matched normal controls. Following hemodialysis, there was a mild reduction in the rCBF by a mean of 7 +/- 2.6% (p = 0.02). The posthemodialysis rCBF reduction was not associated with any neurological or cognitive dysfunction. The causes of hemodialysis-induced rCBF decreases are unknown, but increased blood viscosity and biochemical changes, such as urea reduction and blood alkalinization, may play a role.
Gottlieb
D
D
Department of Neurology, Hadassah University Hospital, Jerusalem, Israel.
Mildworf
B
B
Rubinger
D
D
Melamed
E
E
D000328:Adult; D000368:Aged; D001769:Blood / Q000378:metabolism; D001794:Blood Pressure; D002560:Cerebrovascular Circulation; D003071:Cognition; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D006435:Renal Dialysis / Q000009:adverse effects*; D013997:Time Factors