title: Alternative splicing increases the diversity of the human protein kinase C family.
abstract: Isolation of two protein kinase C (PKC) cDNA clones containing divergent carboxy-terminal sequences suggested a common genetic origin for these cDNAs. Partial characterization of the hPKC beta chromosomal gene provided direct evidence for the existence of two adjacent carboxy-terminal exons (beta 1 and beta 2) that are alternatively spliced to generate two types of hPKC beta sequences. PKC beta 1 and beta 2 mRNAs are expressed in a selective manner in both human hematopoietic cells and bovine brain tissues.
authors: Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080.
authors: L
authors: L
authors: Coussens
authors: L
authors: L
authors: Rhee
authors: P J
authors: PJ
authors: Parker
authors: A
authors: A
authors: Ullrich
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D011493:Protein Kinase C / Q000235:genetics*; D012326:RNA Splicing; D014018:Tissue Distribution
chemical_list: D011493:Protein Kinase C