The pig as an animal model for the study of nitrosamine metabolism.
Surgical procedures have been developed that permit the sampling of portal blood, bile and hepatic blood in intact pigs. Animals so prepared have been used to study liver metabolism and biliary excretion of N-nitrosodimethylamine (NDMA) following oral and intravenous dosing.
Harrington
G W
GW
Department of Chemistry, Temple University, Philadelphia, PA 19122.
Magee
P N
PN
Pylypiw
H M
HM
Bevill
R F
RF
Nelson
D R
DR
Thurmon
J C
JC
D000818:Animals; D001646:Bile / Q000378:metabolism; D004128:Dimethylnitrosamine / Q000378:metabolism; D008099:Liver / Q000098:blood supply / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism*; D011169:Portal Vein; D012016:Reference Values; D013552:Swine / Q000378:metabolism*
D009602:Nitrosamines; D004128:Dimethylnitrosamine