title: The differential effect of optic nerve disease on pattern and focal electroretinograms.
abstract: We studied nine cases of retrobulbar neuritis with confirmed multiple sclerosis and six cases of optic atrophy from other causes. Pattern and focal electroretinograms (macular ERGs) were recorded with high (400 cd/m2) and low (40 cd/m2) intensity stimuli. Contrast sensitivity was also measured with a simple printed test. Luminance was not markedly important. High spatial frequency contrast sensitivity was significantly correlated with pattern ERG amplitude. Pattern and focal ERG amplitude ratio was usually reduced, but the effect was not correlated with contrast sensitivity or large enough to be useful clinically. In optic atrophy the pattern ERG (PERG) was clearly more severely reduced than the focal ERG (FERG). In retrobulbar neuritis both ERGs were equally and more severely reduced even though the visual losses were less. In unilateral cases the PERG increased then decreased after the initial attack, as previously described (Arden et al., 1982). The results suggest that retinal layers beyond the ganglion cells may be affected in retrobulbar neuritis, but proximally generated, pattern-specific ERG components are selectively lost in optic atrophy.
authors: Department of Clinical Ophthalmology, Sydney University, Sydney Eye Hospital, Woolloomooloo, Australia.
authors: Veagan
authors: F A
authors: FA
authors: Billson
mesh_terms: D004596:Electroretinography / Q000379:methods; D006801:Humans; D009896:Optic Atrophy / Q000503:physiopathology; D009901:Optic Nerve Diseases / Q000503:physiopathology*; D009902:Optic Neuritis / Q000503:physiopathology; D010364:Pattern Recognition, Visual