Interaction between human albumin polymers and the envelope polypeptide of hepatitis B virus (P31) containing the translation product of the pre-S2 region.
Two preparations of human serum albumin (Cohn fraction V), when subjected to high-performance liquid chromatography, were found to contain albumin polymers with molecular sizes of 35 X 10(4) daltons or greater (breakthrough fraction), as well as tetramers, trimers and dimers. They bound to the envelope polypeptide of hepatitis B virus composed of translation products of the pre-S2 region and the S gene (P31), carrying the receptor for polymerized human serum albumin, with an activity increasing in parallel with the degree polymerization.
Fukuda
M
M
Hepatitis Division, Tokyo Metropolitan Institute of Medical Science, Japan.
Akahane
Y
Y
Mayumi
M
M
D005796:Genes; D005814:Genes, Viral; D006515:Hepatitis B virus / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D046911:Macromolecular Substances; D008970:Molecular Weight; D014176:Protein Biosynthesis; D011991:Receptors, Virus / Q000235:genetics / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism*
D046911:Macromolecular Substances; D011991:Receptors, Virus; D012709:Serum Albumin; D014759:Viral Envelope Proteins