[Quantitative evaluation of the sensitivity of experimental animals to the diabetogenic effect of alloxan].
A study was made of the time course of development of alloxan diabetes in mature male Wistar and random bred rats for a quantitative analysis of responses to the administration of a diabetogenic dose of the drug. Proceeding from the animals' death, a decrease in body mass, water consumption, the blood level of glucose and GTT results in the animals were divided into 3 groups depending on the gravity of alloxan diabetes. In Wistar rats acute, obvious and latent types of diabetes developed in 35, 35, and 30% respectively. Rats with obvious diabetes were characterized by a significant decrease in the IRI level in the plasma 3-8 weeks after drug administration. In rats with latent diabetes the IRI level in the plasma on the 3rd week showed a tendency to a decrease and exceeded control values in 8 weeks. In random bred rats acute, obvious and latent types of diabetes were noted in 76, 12, and 12% respectively. The results have shown that the division of animals into the groups with a different degree of gravity of alloxan diabetes can express quantitative assessment of the sensitivity of a population in question to the diabetogenic action of alloxan.
Pal'chikova
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Seliatitskaia
V G
VG
Shorin
Iu P
IuP
D000496:Alloxan / Q000633:toxicity*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D006943:Hyperglycemia / Q000139:chemically induced*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000496:Alloxan
Kolichestvennaia otsenka chuvstvitel'nosti éksperimental'nykh zhivotnykh k diabetogennomu deĭstviiu alloksana.