Radioimmunodetection of neuroblastoma with antineuroblastoma monoclonal antibody.
The Antineuroblastoma monoclonal antibody CNM-5 was submitted to preclinical studies and then used for tumor imaging with following results. 1. CNM-5 is an antibody which belongs to the IgM fraction and has a molecular weight of 900 kilodaltons. Its protein concentration was found to be 17.99 mg/dl. 2. The 131I-labeled antibody was injected into nude mice transplanted with human neuroblastoma, and imaging was performed by a gamma camera. Accumulation of 131I in the tumor was relatively clearly seen. Various organs were removed and examined for 131I uptake. Radioactivity was easily detected in the tumor, suggesting that CNM-5 is effective for use in imaging diagnosis of neuroblastoma.
Etoh
T
T
Department of Pediatric Surgery, School of Medicine, Chiba University, Japan.
Takahashi
H
H
Ohnuma
N
N
Maie
M
M
Tanabe
M
M
Kuriyama
Y
Y
D000818:Animals; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009447:Neuroblastoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000276:immunology; D011877:Radionuclide Imaging
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm