Automatic respiratory failure: sleep studies and Leigh's disease (case report).
A 34-year-old woman with a history of chronic nephropathy, kidney transplant rejections, and repeated hemodialysis developed symptoms of automatic respiratory failure during all states of sleep. The neuropathologic examination revealed symmetric brainstem lesions, explaining the sleep-related respiratory failure. Histology affirmed the diagnosis of Leigh's disease.
Cummiskey
J
J
Department of Respiratory Medicine, Santa Clara Valley Medical Center, CA.
Guilleminault
C
C
Davis
R
R
Duncan
K
K
Golden
J
J
D000328:Adult; D001921:Brain / Q000503:physiopathology; D001928:Brain Diseases, Metabolic / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007888:Leigh Disease / Q000150:complications / Q000503:physiopathology*; D012131:Respiratory Insufficiency / Q000150:complications / Q000503:physiopathology*; D012890:Sleep