title: [Absorption, distribution and metabolism of [14C]-levomenol in the skin].
abstract: The purpose of the present investigations was to study the cutaneous absorption of sesquiterpenic alcohol, the major active principle of chamomile. For these investigations 14C-labelled levomenol ((-)-6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol; (-)-alpha-bisabolol) was prepared by biochemical incorporation of [14C]-acetate into the molecule. 5 h after topical application of the radiolabelled substance onto nude mice half of the radioactivity was found in the skin. The other part was measured in tissue and organes. 90% of this radioactivity was analysed as intact levomenol. To demonstrate the distribution of the substance in the skin a part of this tissue was cutted into horizontal slices by a cryotome. From the slices autoradiograms were produced. The densitometric measuration showed that there was a fast penetration of levomenol into the skin. 5 h after the topical application the substance was displaced from outermost to innermost areas. From these results a fast cutaneous absorption and a long therapeutical effect of the antiphlogistic and spasmolytic levomenol in the skin can be expected.
authors: Institut für Pharmazeutische Biologie, Fachbereich Pharmazie und lebensmittelchemie der Philipps-Universität, Marburg/Lahn.
authors: B
authors: B
authors: Hahn
authors: J
authors: J
authors: Hölzl
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001345:Autoradiography; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D051379:Mice; D008819:Mice, Nude; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption
chemical_list: D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes; C004497:bisabolol
vernacular_title: Resorption, Verteilung und Metabolismus von [14C]-Levomenol in der Haut.