Effect of graded low-dose noradrenaline infusions on noradrenaline clearance in normals and essential hypertensives.
1. In normal subjects and essential hypertensives, plasma noradrenaline (NA) levels, and NA clearance (3H-NA constant infusion), were measured during graded infusion of NA. 2. Plasma levels of NA were similar in both groups, with parallel increases to levels approximately three times basal, but still in the upper normal range. 3. Clearance did not increase in either group with increasing plasma NA levels. There was no correlation between plasma NA achieved and NA clearance, which was similar in hypertensives and normotensives. 5. Insofar as plasma clearance reflects tissue clearance, these studies provide no support for the contention that altered NA metabolism might predispose to elevated NA levels in essential hypertension.
Gordon
R D
RD
Endocrine-Hypertension Research Unit, University of Queensland, Greenslopes Hospital, Brisbane, Australia.
Bachmann
A W
AW
Gueizelar
B
B
Dai
Y
Y
D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007262:Infusions, Intravenous; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood / Q000494:pharmacology*
D009638:Norepinephrine