Prader-Willi syndrome in siblings, due to unbalanced translocation between chromosomes 15 and 22.
In a family in which the father carried a balanced translocation between chromosomes 15 and 22 two of his children had Prader-Willi syndrome and an unbalanced chromosome complement, having lost the proximal bands from the long arm of chromosome 15. His four other surviving children were normal but carried a balanced translocation.
Fernandez
F
F
High Wycombe General Hospital.
Berry
C
C
Mutton
D
D
D002675:Child, Preschool; D002872:Chromosome Deletion; D002884:Chromosomes, Human, Pair 15; D002892:Chromosomes, Human, Pair 22; D003241:Consanguinity; D006801:Humans; D008297:Male; D010375:Pedigree; D011218:Prader-Willi Syndrome / Q000235:genetics*; D014178:Translocation, Genetic