[Gamma- and UV-induced DNA synthesis in neurons of the rat neocortex].
Nuclear DNA synthesis in neocortex neurons of neonatal 14- and 60-day rats after in vitro irradiation of isolated sections was estimated by the incorporation of a labeled precursor into DNA. gamma- and UV-radiation increased the rate of DNA synthesis in the cells of animals of all studied age groups. However, the level of the UV-induced synthesis sharply dropped during the postnatal ontogenesis while gamma-radiation-induced synthesis decreased slightly. The peculiarities revealed in the repair DNA synthesis seem to be influenced by the process of postnatal differentiation of a neuron accompanied by the nucleosome length shortening and the decrease in the DNA-polymerase alpha content.
Ivanov
V A
VA
D000375:Aging / Q000378:metabolism / Q000528:radiation effects; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism / Q000528:radiation effects*; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects*; D004260:DNA Repair; D005720:Gamma Rays; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000378:metabolism / Q000528:radiation effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014466:Ultraviolet Rays
D004247:DNA
Gamma- i UF-indutsirovannyĭ sintez DNK v neĭronakh neokorteksa krys.