Lectin binding in retinoblastoma.
Lectins were used as cytochemical probes to examine the relationship between normal retina and retinoblastoma. Cases of retinoblastoma in which there were either Flexner-Wintersteiner rosettes or fleurettes accompanied by nontumorous retina were studied with ten biotinylated lectins. Pineal and ocular tumors from cases of trilateral retinoblastoma were also studied. Con-A, LCA, PNA, WGA and RCA-I labeled tissue of each type to varying degrees, while BS-I, DBA, SBA, S-WGA and UEA-I bound neither tumor nor retina. The high degree of binding homology suggests biochemical as well as structural similarities between these tissues.
Bardenstein
D S
DS
Laboratory of Ophthalmic Pathology, NIH, Bethesda, MD.
Rodrigues
M M
MM
Alroy
J
J
Brownstein
S
S
D005134:Eye Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D012016:Reference Values; D012160:Retina / Q000378:metabolism; D012175:Retinoblastoma / Q000378:metabolism* / Q000473:pathology; D012397:Rosette Formation
D037102:Lectins