S-adenosyl-L-methionine facilitates recovery from deficits in delayed response and hand movement tasks following brain lesions in monkeys.
Effects of S-adenosyl-L-methionine (SAMe) on deficits in a trained delayed response task or trained hand movement tasks after lesions in bilateral dorsolateral prefrontal cortices or the hand-arm area of the unilateral motor cortex in monkeys were studied. Lesions disturbed the delayed response task or hand movement tasks moderately or severely for 1 week to several months depending on the extent of the lesion and nature of the task. Although treatment with small doses of SAMe (10 mg/kg/day, i.m.) had no effect on these disturbances, treatment with moderate doses of SAMe (20 or 30 mg/kg/day, i.m.) reduced impairments and promoted recovery from both disturbances. Pretreatment with SAMe (30 mg/kg/day, i.m.) facilitated recovery from delayed response task deficits due to administration of reserpine (0.3 mg/kg, i.m.) in monkey with bilateral prefrontal cortical lesions, but not in intact monkey. The data suggest that SAMe improves recovery from behavioral disturbances due to brain damage, and this is partly due to increased monoamine turnover rate.
Takahashi
J
J
Department of Physiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Nishino
H
H
Ono
T
T
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000293:injuries*; D006225:Hand; D008251:Macaca; D008568:Memory / Q000187:drug effects; D009044:Motor Cortex / Q000187:drug effects / Q000293:injuries*; D009068:Movement / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012436:S-Adenosylmethionine / Q000494:pharmacology*
D012436:S-Adenosylmethionine; D012110:Reserpine