Effect of ascorbic acid on the metabolism of N-nitrosopiperidine.
Guinea-pigs were fed diets containing 48, 200 or 2000 mg/kg ascorbic acid (AsA) for 20-30 days and given a single oral dose of 50 mg N-nitrosopiperidine (NPIP)/kg body weight. The levels of glutaric acid, 3-hydroxy-NPIP and 4-hydroxy-NPIP, but not of 1,5-pentanediol, in urine increased with the dose of AsA in the diet.
Nakamura
M
M
Kanagawa Prefectural Public Health Laboratory, Yokohama, Japan.
Osada
Y
Y
Horiguchi
Y
Y
Nakaoka
T
T
Ito
K
K
Kawabata
T
T
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D004032:Diet; D006168:Guinea Pigs; D009602:Nitrosamines / Q000378:metabolism* / Q000652:urine
D009602:Nitrosamines; C002743:N-nitrosopiperidine; D001205:Ascorbic Acid