Identification in in vivo acetylation pathway for N-dealkylated metabolites of doxylamine in humans.
1. Metabolites of doxylamine in human urine were separated by g.l.c. and h.p.l.c. and tentatively identified by their mass spectrometric behaviour. 2. N-Desmethyldoxylamine, N,N-didesmethyldoxylamine and their N-acetyl conjugates were identified. This is believed to be the first report of acetylation in vivo of primary and secondary aliphatic amines in man.
Ganes
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DA
College of Pharmacy, University of Saskatchewan, Saskatoon, Canada.
Midha
K K
KK
D000107:Acetylation; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D003640:Dealkylation; D004319:Doxylamine / Q000378:metabolism* / Q000652:urine; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D011725:Pyridines / Q000378:metabolism*
D011725:Pyridines; D004319:Doxylamine