Sr2+ may differentiate high and low affinity Ca2+ stores in guinea-pig trachealis.
1. In guinea-pig trachealis Ca2+ are mobilized from different stores to produce the contractions to various agents. 2. Sr2+ can substitute for Ca2+ and maintain responses to KC1 but not responses to A23187 or agents acting via drug-receptor interaction. 3. Resting tone and responses to KC1 are supported by low affinity Ca2+. 4. Responses to the other agents are supported by high affinity Ca2+.
Raeburn
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Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505.
Rodger
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IW
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D011189:Potassium Chloride / Q000494:pharmacology; D013324:Strontium / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects / Q000378:metabolism
D008688:Methacholine Compounds; D011189:Potassium Chloride; D006632:Histamine; D002118:Calcium; D013324:Strontium