alpha-Tocopherol supplements and high-density-lipoprotein-cholesterol levels.
1. In a randomized, double-blind 6-month study, alpha-tocopherol (728 mg) or placebo were administered daily to seventy-eight volunteers (forty-nine men, twenty-nine women) to investigate the possible enhancing effect of vitamin E on plasma high-density-lipoprotein-cholesterol (HDL-C) levels. In addition, the available reported values from short-term (4-6 weeks) studies, as well as the 4-week results from the present study, were combined and analysed for factors which may modify the effect of alpha-tocopherol on HDL-C. 2. No consistent effect of alpha-tocopherol on plasma HDL-C levels was observed either in the combined 4-week values or in the 6-month study. Further analysis of the combined short-term values and 6-month values indicated that, in subjects with low initial HDL-C levels, treatment with alpha-tocopherol or placebo did not produce significantly different HDL-C changes.
Kalbfleisch
J H
JH
Research Service, Veterans Administration Medical Center, Milwaukee, Wisconsin 53193.
Barboriak
J J
JJ
Else
B A
BA
Hughes
C V
CV
Tristani
F E
FE
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013997:Time Factors; D014810:Vitamin E / Q000494:pharmacology*
D008076:Cholesterol, HDL; D014810:Vitamin E