[Contrast and quantitative characteristics of biological tissues in experimental neoplastic processes based on biexponential relaxation analysis of NMR tomograms].
A method of contrast enhancement and quantification of experimental tumors in vivo by estimation of tissue proton transverse magnetic relaxation nonexponentiality is proposed. Relaxation time and percentage of a rapidly descending magnetization component due to intracellular water protons are followed for tumor and uninvolved tissues in a course of subcutaneously transplanted solid mouse melanoma B16 development. The exponential approximation of a relaxation curve within the 6-90 ms time range is shown to fit melanoma B16 tissue characterization. Contrast-enhanced calculated MR-images are presented.
Iushmanov
V E
VE
Iantsen
V I
VI
Sokolova
I S
IS
Sibel'dina
L A
LA
D000818:Animals; D005260:Female; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008546:Melanoma, Experimental / Q000175:diagnosis*; D051379:Mice; D009368:Neoplasm Transplantation
Kontrastirovanie i kolichestvennaia kharakteristika biologicheskikh tkaneĭ pri éksperimental'nykh opukholevykh protsessakh na osnove biéksponential'nogo relaksatsionnogo analiza IaMR-tomogramm.