Alterations in DNA methylation in human colon neoplasia.
A review of studies on DNA methylation in colonic neoplasia is presented. Hypomethylation of a wide variety of genes from throughout the genome was seen in all colon cancers studied. These changes preceded malignancy because benign adenomas were also affected.
Feinberg
A P
AP
Howard Hughes Medical Institute, Ann Arbor, MI.
Vogelstein
B
B
D000230:Adenocarcinoma / Q000378:metabolism; D003110:Colonic Neoplasms / Q000378:metabolism*; D003111:Colonic Polyps / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism*; D006801:Humans; D008745:Methylation
D004273:DNA, Neoplasm