The subcortical generated somatosensory evoked potentials in non-cephalic, cephalic, and anterior neck referenced recordings in a patient with a cervico-medullary lesion: a clue to the identification of the P14/N14 and N13 generators.
Median nerve somatosensory evoked potentials (SEPs) were studied in a patient before and after the development of a cervico-medullary lesion. The first examination demonstrated normal subcortical generated potentials N13 and N14. The second examination, following a subarachnoid haemorrhage at the cervico-medullary junction, displayed a delayed and reduced amplitude P14/N14 peak on both sides. P14/N14 showed the same latency in all montages, using non-cephalic, cephalic and anterior neck references. The N13 component was not significantly changed in latency compared with the first examination. The latencies of the N13 peak were variable in the different montages. They increased from the lower (C7) to the upper (C2) neck, whereas the latency of the N13 onset was identical in all montages. This alteration might be caused by a delayed near-field activity at C2 overlapping the N13 component. These results fit the hypothesis of two major generators responsible for subcortical SEPs; a near-field N13 component at the level of the lower neck and a far-field P14 component arising from the level of the cervico-medullary junction. An additional minor near-field activity generated by the cuneate nucleus is suspected.
Buchner
H
H
Department of Neurology, Klinikum RWTH Aachen, Federal Republic of Germany.
Ferbert
A
A
Brückmann
H
H
Hacke
W
W
D000328:Adult; D005073:Evoked Potentials, Somatosensory; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology* / Q000503:physiopathology; D013118:Spinal Cord Diseases / Q000503:physiopathology*; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed