Mice genetically selected for differences in open-field activity after ethanol.
Starting from a population of genetically heterogeneous mice, selective breeding is being used to develop lines differing in sensitivity to ethanol-induced open-field activity. Mice are tested twice for 4 min in an open field. The first test is between min 2-6 after injection of saline. Twenty-four hr later, a similar test is performed after injection of ethanol (1.5 g/kg). Two independent FAST lines are being selected for ethanol-induced increases in activity, and two independent SLOW lines are being selected for ethanol-induced decreases. After four generations of selection, the lines have diverged significantly. These lines should be useful for exploring the neuropharmacological basis for the activating and rewarding properties of ethanol.
Crabbe
J C
JC
Department of Medical Psychology, Oregon Health Sciences University, Portland.
Young
E R
ER
Deutsch
C M
CM
Tam
B R
BR
Kosobud
A
A
D000818:Animals; D001947:Breeding; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005824:Genetics, Behavioral / Q000187:drug effects*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*
D000431:Ethanol