Cancer mortality among relatives of children with soft-tissue sarcoma: a national survey in Italy.
Information was obtained on the living status or cause of death of 2223 close relatives of 195 children with soft-tissue sarcomas (STS) diagnosed under age 15. Three-hundred nine relatives had died, from all causes, before STS diagnosis in the index child. The expected figure estimated from age- and sex-specific mortality rates in Italy was 293.3. Cancer was reported as cause of death in 76 relatives (75.1 expected). Seven grandmothers, 2 aunts, 1 uncle and 0 mothers died from breast cancer vs. 4.6, 0.9, 0.0 and 0.2 expected. Three siblings died from cancer (0.2 expected, P less than 0.01), i.e. STS, ependymoma and non-Hodgkin lymphoma. These results confirm and expand previous observations that STS in children are associated with other cancers, particularly childhood and breast cancer, in members of the same family.
Pastore
G
G
Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Italy.
Mosso
M L
ML
Carli
M
M
Ghibaudo
P
P
De Bernardi
B
B
Mancini
A
A
Pianca
C
C
Grotto
P
P
Terracini
B
B
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006306:Health Surveys; D006801:Humans; D007223:Infant; D007558:Italy; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000235:genetics; D012509:Sarcoma / Q000235:genetics* / Q000401:mortality; D012737:Sex Factors; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000401:mortality