title: The use of the Hellige Oxymonitor to study skin blood flow changes.
abstract: Transcutaneous oxygen tension is a flow related parameter. Detailed analysis of the physiology and physical chemistry of oxygen consumption and diffusion indicates that tcPO2 is not proportional to skin blood flow. Measurement of tcPO2 at 37 degrees C allows changes in skin blood flow to be clearly demonstrated and is of use in many areas of clinical medicine. Transcutaneous oxygen tension recorded using a polarographic oxygen electrode depends on skin blood flow, skin respiration, arterial oxygen concentration, temperature, skin and electrode permeability and the oxygen consumption of the electrode. Applying clearance principles, the relationship between blood flow, respiration and the difference between arterial and venous oxygen concentrations is well established. This has long been used to measure cardiac output, since the other three parameters are readily determined. Arterial saturation is normally greater than 95% of maximum in subjects without lung disease and it may thus be considered to be constant. Tissue respiration is independent of oxygen concentration when PO2 exceeds 2 mm Hg. If skin respiration is invariant at constant temperature, when the tissue oxygen tension exceeds 2 mm Hg, then blood flow is inversely proportional to the difference in concentration between arterial and venous blood. It has recently been directly shown that the inference that tissue respiration is independent of tissue blood flow is accurate. Correcting for the oxyhaemoglobin dissociation curve and for the deviation from zero order respiration kinetics when tissue PO2 less than 2 mm Hg, the relationship between venous oxygen tension and blood flow at 37 degrees C is shown when arterial oxygen concentration is constant (Figure 1).(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Department of Dermatology, Royal Free Hospital, London, U.K.
authors: P M
authors: PM
authors: Gaylarde
authors: I
authors: I
authors: Sarkany
mesh_terms: D001783:Blood Flow Velocity; D001785:Blood Gas Monitoring, Transcutaneous / Q000295:instrumentation*; D002196:Capillaries / Q000502:physiology; D006801:Humans; D010100:Oxygen / Q000097:blood; D005082:Physical Exertion; D011187:Posture; D012867:Skin / Q000098:blood supply*; D012881:Skin Temperature; D014690:Venous Pressure
chemical_list: D010100:Oxygen