Effect of gallium at two phases of the CA 755 tumour growth.
GaCl3 efficiency was evaluated for mice mammary adenocarcinoma Ca-755 separately at two stages of tumour growth: the exponential and plateau phase. Two modalities of drug administration were evaluated: once only and twice a day for five days. Comparisons were made with the efficiency observed when saline liquid and cyclophosphamide were used. The comparisons between tumour shrinkages were carried out by non-parametric tests. GaCl3 was more often efficient for tumours at the exponential phase than for those at the plateau phase of growth. GaCl3 always appeared less efficient than cyclophosphamide. The treatment schedule did not result in any significant alteration of tumour regression.
Carpentier
Y
Y
Institut Jean Godinot, Reims, France.
Liautaud-Roger
F
F
Labbe
F
F
Loirette
M
M
Collery
P
P
Coninx
P
P
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D002453:Cell Cycle; D003520:Cyclophosphamide / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005708:Gallium / Q000008:administration & dosage*; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy*; D051379:Mice
D003520:Cyclophosphamide; D005708:Gallium