Protective effect of ST-93 against ouabain induced arrhythmias in guinea pigs.
ST-93, a clonidine analog was studied for its antiarrhythmic activity in anaesthetised guinea pigs against ouabain induced arrhythmia. The amount of ouabain required (micrograms/kg) for the production of ventricular premature best. Ventricular fibrillation and cardiac arrest was recorded in control and drug treated group of animals. Both ST-93 and clonidine produced significant antiarrhythmic effect in guinea pigs. This protective effect was significantly blocked by yohimbine, suggesting that the antiarrhythmic effect is mediated through presynaptic alpha 2-adrenoceptors.
Tripathi
R M
RM
Department of Pharmacology, IDPL Research Centre, Hyderabad.
Kaushal
R
R
Veeranjaneyulu
A
A
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D010042:Ouabain; D015016:Yohimbine / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D015016:Yohimbine; C054060:St 93; D010042:Ouabain; D003000:Clonidine