Determination of residual solvents in pharmaceutical products by gas chromatography coupled to a head-space injection system and using an external standard.
A method of determination of residual solvents in powders using gas chromatography with an head-space injection system has been developed. The chromatographic conditions and parameters of the injection system were optimized to enable the quantification by external standardization of most common solvents in concentrations ranging from a few ppm to a few per cent.
Guimbard
J P
JP
Sanofi Recherche, Montpellier, France.
Person
M
M
Vergnaud
J P
JP
D002849:Chromatography, Gas / Q000295:instrumentation; D004340:Drug Contamination / Q000032:analysis*; D007202:Indicators and Reagents; D011208:Powders / Q000032:analysis; D012997:Solvents / Q000032:analysis*; D013696:Temperature
D007202:Indicators and Reagents; D011208:Powders; D012997:Solvents