title: Radioimaging of human ovarian carcinoma xenograft in nude mice.
abstract: Human ovarian carcinomas in nude mice were radioimaged using a well-characterized antibody against a tumor-associated antigen (CA 125) and three transplantable human ovarian carcinoma tumor lines: NIH:OVCAR 3, NIH:OVCAR 5, and NIH:OVCAR 9. Radioiodinated monoclonal antibody OC125 was used in these studies. In order to establish the optimal conditions for imaging, tumor/blood ratios were determined. Gamma scintigraphy of nude mice bearing subcutaneous transplants of human ovarian carcinomas 3-4 days after 131I-OC125 administration demonstrated selective localization of the radiolabeled monoclonal antibody by these tumors without need for any background subtraction techniques.
authors: Department of Obstetrics and Gynecology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
authors: A
authors: A
authors: Manetta
authors: P G
authors: PG
authors: Satyaswaroop
authors: T
authors: T
authors: Hamilton
authors: R
authors: R
authors: Ozols
authors: R
authors: R
authors: Mortel
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis; D002460:Cell Line; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000032:analysis; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000032:analysis / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D014183:Transplantation, Heterologous
chemical_list: D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes