Pharmacokinetics and tissue penetration of roxithromycin after multiple dosing.
The pharmacokinetics of the macrolide roxithromycin (RU 28965) were studied during and after administration of 150 mg every 12 h for 3 days (five doses) in six volunteers. The concentrations in serum, blister fluid, and urine were measured. Mean levels in serum taken at 1.5 h after the morning dose increased from 4.4 micrograms/ml on day 1 to 5.9 micrograms/ml on day 2 and 7.4 micrograms/ml on day 3. The mean serum and blister fluid elimination half-lives on day 3 were 13.2 and 12.5 h, respectively. Roxithromycin penetrated blister fluid well; the mean percent penetration (as measured by the ratio of areas under the curve) was 85%. After the final dose, a mean of 10.5% of that dose was recovered in 12 h as microbiologically active compound.
Wise
R
R
Department of Microbiology, Dudley Road Hospital, Birmingham, England.
Kirkpatrick
B
B
Ashby
J
J
Andrews
J M
JM
D000328:Adult; D006801:Humans; D007933:Leucomycins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D014018:Tissue Distribution
D007933:Leucomycins