title: Ovarian yolk sac tumor arising from an endometrioid carcinoma.
abstract: A yolk sac tumor that arose within an ovarian endometrioid adenocarcinoma in a 50-year-old woman is described. The tumor had typical microscopic features, stained immunohistochemically for alpha-fetoprotein, and was associated with an elevated serum alpha-fetoprotein level when metastases appeared. This is the fourth case in which a yolk sac tumor has been reported to develop from a somatic carcinoma and the second in which this tumor has been associated with epithelium of endometrioid type. Tumor heterogeneity or neometaplasia may account for the origin of a tumor of germ cell type from a carcinoma of somatic origin.
authors: Department of Pathology, Harvard Medical School, Boston, Massachusetts.
authors: J L
authors: JL
authors: Rutgers
authors: R H
authors: RH
authors: Young
authors: R E
authors: RE
authors: Scully
mesh_terms: D002277:Carcinoma / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D008649:Mesonephroma / Q000209:etiology* / Q000473:pathology / Q000556:secondary; D008875:Middle Aged; D009852:Omentum; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000556:secondary; D014594:Uterine Neoplasms / Q000150:complications* / Q000473:pathology