Inhibitory action of flurbiprofen and mopidamole on tumor lung metastasis formation in mice.
Flurbiprofen, 0.25 mg/kg, administered to mice orally once daily during 3 days prior to an iv transplantation of Lewis lung carcinoma cells, protected 50%-57% of experimental animals from the formation of lung tumor colonies. With the daily dose of 1.0 mg/kg, this effect was less pronounced. Mopidamole, twice daily 90 mg/kg orally during 3 days, did not have this effect.
Mamytbeková
A
A
Research Institute for Pharmacy and Biochemistry, Prague, Czechoslovakia.
Rezábek
K
K
Grimová
J
J
Svobodová
J
J
D000284:Administration, Oral; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005480:Flurbiprofen / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009012:Mopidamol / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D011422:Propionates / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*
D011422:Propionates; D011743:Pyrimidines; D009012:Mopidamol; D005480:Flurbiprofen