Methotrexate neuroenteropathy--a histochemical study.
10 mg/kg Methotrexate was injected daily for 5 d a week for a total period of 3 weeks and its effect on autonomic nerve profiles of jejunum was studied using histochemical methods. Initially (after 5 doses in a week) partial degeneration of adrenergic and cholinergic nerve supply was observed. Prolonged treatment (15 does in 3 weeks) was responsible for disappearance of about 30% of adrenergic and 50% of cholinergic nerve profiles. Early degenerative changes in the cholinergic nerve cells of the intestinal plexuses was also noted.
el-Badawi
M G
MG
Department of Anatomy, College of Medicine, Riyadh, Saudi Arabia.
Fatani
J A
JA
Qayyum
M A
MA
D000110:Acetylcholinesterase / Q000378:metabolism; D000320:Adrenergic Fibers / Q000187:drug effects; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D002799:Cholinergic Fibers / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007583:Jejunum / Q000294:innervation*; D008727:Methotrexate / Q000633:toxicity*; D008856:Microscopy, Fluorescence; D009410:Nerve Degeneration / Q000187:drug effects*
D000110:Acetylcholinesterase; D008727:Methotrexate