[Effect of actinomycin D on the survival and recovery capacity of irradiated connective tissue cells in the Chinese hamster].
Simultaneous treatment of Chinese hamster fibroblasts with Actinomycin D and gamma rays under normal aerobic conditions leads to radiosensitization. In contrast to Actinomycin D pretreatment, modification to the effect of radiation is drug dose dependent in the case of post-treatment. No effect of Actinomycin D upon the shape of the radiation cell survival curve is seen under hypoxic conditions. Recovery from radiation damage in split dose experiments is not influenced by the drug.
Ziegler
W
W
Strahlenbiologisches Institut der Ludwig-Maximilians-Universität, München.
D000693:Anaerobiosis; D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D003238:Connective Tissue / Q000187:drug effects / Q000528:radiation effects*; D003239:Connective Tissue Cells; D006224:Cricetinae; D003412:Cricetulus; D003609:Dactinomycin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D011836:Radiation Tolerance
D003609:Dactinomycin
Der Einfluss von Actinomycin D auf das Uberleben und die Erholungsfähigkeit bestrahlter Bindegewebszellen des chinesischen Hamsters.