Assay of 1-nitropropane, 2-nitropropane, 1-azoxypropane and 2-azoxypropane for carcinogenicity by gavage in Sprague-Dawley rats.
1-Nitropropane (1-NP), 2-nitropropane (2-NP), 1-azoxypropane (1-AP) and 2-azoxypropane (2-AP), were assayed for carcinogenicity by gavage in male Sprague-Dawley rats. 2-NP was given at 1 mmol/kg three times per week for 16 weeks. 1-NP (1 mmol/kg), 1-AP (0.1 mmol/kg), 2-AP (0.1 mmol/kg) or Emulphor EL-620 vehicle was given three times per week for 16 weeks, and then once per week for 10 weeks. In the 2-NP treated group both benign and malignant liver tumors occurred in 100% of the animals. No treatment related tumors occurred in rats receiving 1-NP. In rats treated with 1-AP, a high incidence of skin tumors (100%), mostly keratoacanthomas, and of tumors of the nasal cavity (59%) was observed. Rats which were given 2-AP also showed an increased incidence of skin keratoacanthomas (21%), but not of other tumors. These findings (i) confirm, using the oral route of administration, the results of inhalation studies by others indicating the potent hepatocarcinogenicity of 2-NP, (ii) establish a practical model in which the mechanism of 2-NP carcinogenicity can now be more readily studied, and (iii) demonstrate that 1-AP, and probably 2-AP, like other aliphatic azoxy compounds thus far examined, are carcinogenic in rats.
Fiala
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Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, NY 10595.
Czerniak
R
R
Castonguay
A
A
Conaway
C C
CC
Rivenson
A
A
D000473:Alkanes / Q000633:toxicity*; D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D007636:Keratoacanthoma / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D009152:Mutagenicity Tests; D009595:Nitroparaffins / Q000633:toxicity*; D010938:Plant Oils; D011407:Propane / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains / Q000378:metabolism*; D012878:Skin Neoplasms / Q000139:chemically induced
D000473:Alkanes; D001391:Azo Compounds; D009595:Nitroparaffins; D010938:Plant Oils; C054239:2-azoxypropane; C054237:1-azoxypropane; C035314:1-nitropropane; C016617:2-nitropropane; D011407:Propane