The chronic administration of dopamine antagonists and methamphetamine changed the [3H]-cholecystokinin-8 binding sites in the rat frontal cortex.
The specific cholecystokinin (CCK) binding in the slide-mounted tissue sections of the rat frontal cortex was measured with [3H]-CCK-8. The binding was saturable, reversible, high in affinity, and inhibited by caerulein. The chronic administration of dopamine (DA) antagonists and methamphetamine (MAP) showed a tendency to increase the [3H]-CCK-8 binding sites (Bmax) in the frontal cortex. Long-term treatments with DA antagonists led to the depletion of CCK-8 and may have caused an observed proliferation of CCK-8 receptors in the frontal cortex.
Fukamauchi
F
F
Department of Neuropsychiatry, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
Yoshikawa
T
T
Kaneno
S
S
Shibuya
H
H
Takahashi
R
R
D000818:Animals; D018492:Dopamine Antagonists; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011949:Receptors, Cholecystokinin / Q000187:drug effects*; D012844:Sincalide / Q000378:metabolism; D014316:Tritium
D018492:Dopamine Antagonists; D011949:Receptors, Cholecystokinin; D014316:Tritium; D008694:Methamphetamine; D012844:Sincalide