title: Solid phase synthesis of oligoribonucleotides using the o-nitrobenzyl group for 2'-hydroxyl protection and H-phosphonate chemistry.
abstract: Oligoribonucleotides with chain length of 7, 11, 15, 17, 24 and 34 were synthesized on long chain alkylamine controlled pore glass beads (LCA-CPG) using o-nitrobenzyl protection of 2'-hydroxyls via a H-phosphonate approach either manually or by using an automatic synthesizer. The oligoribonucleotides were obtained in yields of 0.6 0.6-20%, based on initial nucleoside bound to the LCA-CPG support.
authors: Faculty of Pharmaceutical Sciences, Osaka University, Japan.
authors: T
authors: T
authors: Tanaka
authors: S
authors: S
authors: Tamatsukuri
authors: M
authors: M
authors: Ikehara
mesh_terms: D001331:Automation; D001483:Base Sequence; D008722:Methods; D009843:Oligoribonucleotides / Q000138:chemical synthesis*
chemical_list: D009843:Oligoribonucleotides