title: Hormonal consequences of orchidectomy for carcinoma of the prostate. With special reference to the measurement of free testosterone in the saliva.
abstract: 22 patients with metastatic carcinoma of the prostate were treated by subcapsular orchidectomy and followed by regular determinations of plasma T, DHT, D4A Dione, SDHEA, and TeBG as well as salivary T which measures the free Testosterone. Subcapsular orchidectomy constantly induced a dramatic and stable decrease of testicular androgens or TeBG. Free Testosterone levels vary widely for a given value of plasma T, probably due to individual variations of TeBG. Therefore salivary T should be used preferably to plasma T to monitor hormonal therapy of metastatic carcinoma of the prostate.
authors: Clinique Urologique, Hôpital Cochin, Paris, France.
authors: L
authors: L
authors: Boccon-Gibod
authors: M H
authors: MH
authors: Laudat
authors: D
authors: D
authors: Guiban
authors: A
authors: A
authors: Steg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000601:surgery; D012463:Saliva / Q000032:analysis*; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000032:analysis*
chemical_list: D012738:Sex Hormone-Binding Globulin; D013739:Testosterone