[Emotional behavior disorders in rats during the formation of a generator of pathologically enhanced excitation in the basomedial nuclei of the amygdaloid complex].
Microinjections of kainic acid and ferrous sulfate into basomedial nuclei of both amygdalae resulted in the formation of the generator of pathologically enhanced excitation (GPEE), as evidenced by the epileptical activity (EpA) registered in both nuclei. EpA of different intensity and pattern could be retained for more than three weeks. Hyperactive basomedial nuclei played the role of a primary pathological determinant which caused the complex of emotional and behavioural disorders. Continuous motor depression at the early stages alternated pathologically enhanced activity at the later stages. A number of signs could be considered as the evidence of the affective disorders (motivation suppression, enhanced irritation, anxious excitation). Stereotype behaviour, immobility, rigidity, different types of vegetative disorders (ptosis, constipation, piloerection, loss of weight, respiratory arrhythmia, dystrophic symptoms) were observed in most animals. The emotional, behavioural and vegetative disorders described are compared to the manifestations of the depressive syndrome.
Kryzhanovskiĭ
G N
GN
Rodina
V I
VI
D000342:Affective Symptoms / Q000503:physiopathology*; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D008297:Male; D051381:Rats
Emotsional'no-povedencheskie rasstroĭstva u krys pri sozdanii generatora patologicheski usilennogo vozbuzhdeniia v bazomedial'nykh iadrakh mindalevidnogo kompleksa.