[The effect of cisapride on gastric emptying time and release of gastrointestinal hormones].
Cisapride is a novel gastrointestinal prokinetic drug. The aim of the present study was to investigate gastric emptying time and secretion of gastrointestinal hormones (Gastrin, Motilin, Glucagon) after single oral intake of 5 mg or 10 mg cisapride. The healthy men aged 23-55 years participated the study. The gastric emptying time and gastrointestinal hormones were measured by gamma-camera radioisotopic technique and radioimmunoassay, respectively. The half time of emptying phase was reduced from 31.78 min to 29.88 min, and emptying rate increased in 10 mg cisapride group. There was a tendency that cisapride accelerated a stimulation of Motilin secretion.
Ebina
H
H
Sendai general hospital of J.N.R.
Satoh
M
M
Nakamura
M
M
Hongo
M
M
Toyota
T
T
D000328:Adult; D020117:Cisapride; D005746:Gastric Emptying / Q000187:drug effects*; D005755:Gastrins / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D005934:Glucagon / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009037:Motilin / Q000378:metabolism; D010880:Piperidines / Q000494:pharmacology*; D013268:Stimulation, Chemical
D005755:Gastrins; D005768:Gastrointestinal Hormones; D010880:Piperidines; D009037:Motilin; D005934:Glucagon; D020117:Cisapride