[Growth-stimulating effect of UF-irradiated blood. I. The radiation dose dependence of the initial growth potencies of blood and of the functional state of the target cells].
UV irradiation (UVI) of donor blood in the apparatus used in hospitals of the USSR with the therapeutic aim of autotransfusion of UV-irradiated blood (AUVIB), results in an increase of connective tissue cell growth potency: being added into culture media the supernatants of irradiated blood stimulate DNA-synthetic and proliferative activity of cultured human embryonic cells. The high activity of cells persists for about 2 days. The effect is great with low initial levels of cell proliferative activity. In this case the effect is maximum (about 125% of the control). It is suggested that the above effect may be involved in the mechanism of stimulation of regeneration processes in the organism after AUVIB.
Firulina
I I
II
Samoĭlova
K A
KA
Belisheva
N K
NK
D001345:Autoradiography; D001769:Blood / Q000528:radiation effects*; D001804:Blood Transfusion, Autologous / Q000295:instrumentation; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006133:Growth Substances / Q000528:radiation effects*; D006801:Humans; D013997:Time Factors; D014466:Ultraviolet Rays; D014467:Ultraviolet Therapy / Q000295:instrumentation
D006133:Growth Substances; D004247:DNA
Rostostimuliruiushchiĭ éffekt obluchennoĭ UF luchami krovi. I. Zavisimost' ot dozy oblucheniia iskhodnykh rostovykh potentsiĭ krovi i funktsional'nogo sostoianiia kletok-misheneĭ.