Effect of dietary lipids on renal function in rats with subtotal nephrectomy.
Female rats with 1-3/4 nephrectomy were divided in two groups and pair fed for five weeks diets differing in their linoleic acid content. Five weeks after subtotal nephrectomy, values for glomerular filtration rate and renal plasma flow were significantly higher and the values of blood pressure significantly lower in rats fed a diet rich in linoleic acid. Systolic blood pressure averaged 156 +/- 5.6 mm Hg in high and 215 +/- 8.1 mm Hg in low linoleic acid-fed rats. Differences in the values of blood pressure between the two groups were observed three weeks after subtotal renal ablation and persisted throughout the period of observation. Inulin clearance averaged 0.89 +/- 0.07 ml/min in the high and 0.44 +/- 0.05 ml/min in the low linoleic acid group. Protein excretion in the urine was significantly less in rats fed the high linoleic acid diet (36.9 +/- 4.4 mg/24 hr) than in those fed the low linoleic acid diet (90.1 +/- 12.5 mg/24 hr). The weight of the remnant kidney five weeks after subtotal renal ablation was greater in rats fed a low linoleic acid diet as compared to those fed a high linoleic acid diet (P less than 0.05). Glomerular lesions were more severe in rats fed a low linoleic acid diet than in those fed a high linoleic acid diet. Feeding high linoleic acid diets to normal and subtotally nephrectomized rats increased the content of linoleic and arachidonic acid in renal cortex and medulla.(ABSTRACT TRUNCATED AT 250 WORDS)
Heifets
M
M
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Morrissey
J J
JJ
Purkerson
M L
ML
Morrison
A R
AR
Klahr
S
S
D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D007444:Inulin; D007668:Kidney / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D007677:Kidney Function Tests; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage* / Q000494:pharmacology; D009392:Nephrectomy; D011453:Prostaglandins / Q000652:urine; D011507:Proteinuria; D051381:Rats; D011919:Rats, Inbred Strains; D010130:p-Aminohippuric Acid
D004041:Dietary Fats; D005227:Fatty Acids; D008041:Linoleic Acids; D011453:Prostaglandins; D007444:Inulin; D019787:Linoleic Acid; D010130:p-Aminohippuric Acid