[Effect of 1-(chloromethyl)silatrane on the alteration of the blood elements during extracorporeal circulation].
The damaging effect of cardiopulmonary bypass on blood elements and the possibility of its correction with 1-(chloromethyl) silatrane have been investigated. Cardiopulmonary bypass is a powerful damaging factor producing a wide range of effects including the activation of lipid peroxidation, reduction of erythrocyte membrane resistance to ultra-sound, destruction of blood elements and appearance of hemoglobin in the plasma (hemolysis). A possible mechanism of cardiopulmonary bypass damaging effect on blood elements is suggested. The use of 1-(chloromethyl)silatrane drastically increases the resistance of blood element membranes to injury, which seems promising for the drug application during cardiopulmonary bypass.
Pisarskiĭ
Iu B
IuB
Kazimirovskaia
V B
VB
Voronkov
M G
MG
D000818:Animals; D004285:Dogs; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005112:Extracorporeal Circulation; D006454:Hemoglobins / Q000032:analysis; D007700:Kinetics; D008054:Lipid Peroxides / Q000097:blood; D017646:Organosilicon Compounds; D010084:Oxidation-Reduction / Q000187:drug effects; D012825:Silicon / Q000494:pharmacology*; D013997:Time Factors
D006454:Hemoglobins; D008054:Lipid Peroxides; D017646:Organosilicon Compounds; C033818:1-(chloromethyl)silatrane; D012825:Silicon
Vliianie 1-(khlormetil) silatarana na al'teratsiiu élementov krovi v usloviiakh ékstrakorporal'nogo krovoobrashcheniia.