[Mathematical models in clinical radiobiology and optimization of the radiotherapy of tumors].
A mathematical model was developed in the system of tumor-normal tissues. It reflected the main radiobiological factors and regularities of tumor growth kinetics: heterogeneity of cell populations with relation to radiosensitivity and a tendency to proliferation, the effects of reoxygenation. Using a package of RADON applied programs optimum irradiation regimens were obtained simultaneously for single doses and intervals of interfractional recovery. Optimum irradiation regimens were shown to be dynamic fractionation of a total dose and the entire period of treatment.
Ivanov
V K
VK
Aĭrapetov
S A
SA
D002470:Cell Survival / Q000528:radiation effects; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D010101:Oxygen Consumption / Q000528:radiation effects; D011881:Radiotherapy, Computer-Assisted
Matematicheskoe modelirovanie v klinicheskoĭ radiobiologii i optimizatsiia luchevoĭ terapii opukholeĭ.