L-methionine enhances the contractile response to norepinephrine of rat vas deferens.
Under Ca-depleted conditions, the contractile responses of rat vas deferens in the presence of norepinephrine were not elicited until the addition of CaCl2. L-Methionine enhanced the contractile response of vas deferens in the presence of methylation blockers under these conditions. The enhancing effect of L-methionine on some other smooth muscles could not be determined because under Ca-depleted conditions, these muscles showed 60-80% of the maximal contractile response on addition of CaCl2 alone. These findings suggested that L-methionine has an enhancing effect on contraction of the rat vas deferens as it does on rat uterine muscle.
Ichida
S
S
Department of Biological Chemistry, Faculty of Pharmacy, Kinki University, Higashi-Osaka, Japan.
Yoshioka
K
K
Oka
H
H
Oda
Y
Y
Ariyoshi
S
S
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006710:Homocysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008715:Methionine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014372:Tubercidin / Q000494:pharmacology; D014649:Vas Deferens / Q000187:drug effects
C018258:3-deazaadenosine; D006710:Homocysteine; D008715:Methionine; C007957:homocysteine thiolactone; D014372:Tubercidin; D002118:Calcium; D009638:Norepinephrine