Mode of action of antiprotozoan agents. Electron transfer and oxy radicals.
Cyclic voltammetry data were obtained for most of the main classes of antiprotozoan agents, specifically, nitroheterocycles, quinones, metal complexes and derivatives, iminium-type ions, and azo compounds. The reductions were generally reversible in the range of -0.3 to -0.9 V. Catalytic production of oxidative pressure from redox cycling involving oxygen is believed to be an important mode of action by the medicinal agents. Literature data contribute support.
Ames
J R
JR
Department of Chemistry, University of Wisconsin-Milwaukee 53201.
Ryan
M D
MD
Kovacic
P
P
D000981:Antiprotozoal Agents / Q000494:pharmacology*; D001391:Azo Compounds / Q000494:pharmacology; D002614:Chelating Agents / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004579:Electron Transport; D005609:Free Radicals; D007097:Imines / Q000494:pharmacology; D010084:Oxidation-Reduction; D011809:Quinones / Q000494:pharmacology
D000981:Antiprotozoal Agents; D001391:Azo Compounds; D002614:Chelating Agents; D005609:Free Radicals; D007097:Imines; D011809:Quinones