[Effect of clonidine on the basic mechanisms of hemostasis, secretory activity of the stomach and the regulation of cardiac rhythm].
A study of 31 individuals (8 normal subjects and 23 patients with peptic ulcer) demonstrated that a single therapeutic dose (0.002 mg/kg) of clonidine, administered to individuals with normal hemodynamic parameters, slightly reduced their heart rate (by 7-8%), and arterial blood pressure (by 12-19%), had a modulating effect on blood aggregation, unaffected blood sugar and depressed dramatically basal gastric secretion of acid and pepsin, and, to a lesser extent, that of bicarbonates. This range of clonidine effects suggests that it may be useful in combined cases of arterial hypertension and gastric hypersecretion, yet the treatment should be relatively short-term and low-dose, because of a risk of gastric vasoconstriction.
Fisher
A A
AA
Gel'vikh
V I
VI
Kaliuzhnaia
E N
EN
Sakha
S K
SK
D000293:Adolescent; D000328:Adult; D003000:Clonidine / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000503:physiopathology*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects*; D006487:Hemostasis / Q000187:drug effects*; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D008875:Middle Aged
D003000:Clonidine
Vliianie klonidina na osnovnye mekhanizmy gemostaza, sekretornuiu deiatel'nost' zheludka i reguliatsiiu serdechnogo ritma.