[Activation of lipolysis and ketogenesis in tumor-bearing animals as a reflection of chronic stress states].
In order to elucidate the peculiarities of brain metabolism in tumour-bearing organisms, the arterio-venous (A-V) content of glucose, acetoacetate (Ac-Ac), beta-hydroxybutyrate (beta-HB) and non-esterified fatty acids (NEFA) in growing Zajdela ascite hepatoma (ZAH) and solid hepatoma 27 (H-27) was compared. Analysis of metabolic patterns of healthy, starving and fed recipients (ZAH and H-27) revealed the inadequacy of the concepts on anorexia as being the cause of carbohydrate-lipid metabolic disturbances. In tumour-bearing organisms lipolysis and ketogenesis reflect the tumour-induced chronic stress. Absorption of beta-HB and release of Ac-Ac by brain were observed at all stages of malignant growth. This is probably due to a partial switch-over of brain metabolism to non-carbohydrate energy sources. Besides, certain stages of tumour growth are associated with active assimilation of NEFA by brain. A correlation between the A-V difference with respect to glucose and Ac-Ac as well as between the glucose and NEFA contents was established. It was assumed that the A-V difference in glucose is the main regulator of ketone body metabolism.
Chekulaev
V A
VA
Shelepov
V P
VP
Pasha-zade
G R
GR
Shapot
V S
VS
D000090:Acetoacetates / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002908:Chronic Disease; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006885:Hydroxybutyrates / Q000097:blood; D007657:Ketone Bodies / Q000096:biosynthesis*; D008066:Lipolysis; D008114:Liver Neoplasms, Experimental / Q000150:complications / Q000378:metabolism*; D008297:Male; D051381:Rats; D013312:Stress, Physiological / Q000209:etiology / Q000378:metabolism*
D000090:Acetoacetates; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007657:Ketone Bodies; C016635:acetoacetic acid
Aktivatsiia lipoliza i ketogeneza v opukholevom organizme kak otrazhenie khronicheskogo stressornogo sostoianiia.