title: cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.
abstract: Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is very similar to human plasminogen. It contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is present in 37 copies.
authors: Department of Cardiovascular Research, Genentech, Inc., South San Francisco, California 94080.
authors: J W
authors: JW
authors: McLean
authors: J E
authors: JE
authors: Tomlinson
authors: W J
authors: WJ
authors: Kuang
authors: D L
authors: DL
authors: Eaton
authors: E Y
authors: EY
authors: Chen
authors: G M
authors: GM
authors: Fless
authors: A M
authors: AM
authors: Scanu
authors: R M
authors: RM
authors: Lawn
mesh_terms: D000595:Amino Acid Sequence; D001054:Apolipoproteins A / Q000235:genetics*; D001483:Base Sequence; D005075:Biological Evolution; D004247:DNA / Q000302:isolation & purification*; D006801:Humans; D008969:Molecular Sequence Data; D010958:Plasminogen / Q000235:genetics*; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid
chemical_list: D001054:Apolipoproteins A; D010958:Plasminogen; D004247:DNA