Effect of butyric acid on 12-O-tetradecanoylphorbol-13-acetate-(TPA) induced mouse skin ornithine decarboxylase (ODC).
Butyric acid was topically applied on the interscapular region of Swiss albino mice before and after application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in various doses and at different time intervals. Skin taken from the painted area, 4 h after TPA application, was subjected to ornithine decarboxylase (ODC) enzyme estimation. It was found that butyric acid inhibited the TPA-induced mouse skin ODC activity. The effect was dependent on the dose and duration of the butyric acid application.
Gupta
K P
KP
Laboratory of Industrial and Environmental Carcinogenesis, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Mehrotra
N K
NK
D000818:Animals; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D051379:Mice; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D012867:Skin / Q000187:drug effects* / Q000201:enzymology; D012878:Skin Neoplasms / Q000139:chemically induced; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D013997:Time Factors
D002087:Butyrates; D020148:Butyric Acid; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate