In-vitro fertilization results from thirteen women with anti-sperm antibodies.
Thirteen infertile women with high titres of spermagglutinating antibodies in their serum and/or in cervical mucus underwent in-vitro fertilization (IVF) and embryo transfer (ET). Fertilization occurred in 68% of the oocytes in a serum-free medium. Eight pregnancies were obtained in 22 IVF cycles (36.4%). Anti-sperm antibodies were found in the follicular fluids of 5 out of the 11 women with circulating antibodies. Fertilization results were independent of both the localization and the level of anti-sperm antibodies. From these data we can conclude that IVF-ET is a suitable treatment for long lasting female infertility linked to anti-sperm immunity.
De Almeida
M
M
Institut National de la Santé et de la Recherche Médicale, Unité 23, Hôpital Saint-Antoine, Paris, France.
Herry
M
M
Testart
J
J
Belaisch-Allart
J
J
Frydman
R
R
Jouannet
P
P
D000906:Antibodies / Q000032:analysis*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000276:immunology / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D011379:Prognosis; D013094:Spermatozoa / Q000276:immunology*
D000906:Antibodies