title: Cerebellar glucose metabolism in chronic aphasia.
abstract: (18F)-Fluorodeoxyglucose PET was used to compare left/right cerebellar hemispheric glucose metabolism in 37 aphasic patients with left hemisphere lesions and 22 age-matched controls. Sixteen aphasic subjects showed cerebellar symmetry. Twenty-one aphasic subjects were found to have cerebellar metabolic asymmetry, which (1) resulted from an absolute reduction in local cerebral metabolic rates of glucose in the right cerebellar hemisphere; (2) was associated with left less than right glucose metabolic asymmetry in the frontal, parietal, caudate, and thalamic regions; (3) was associated with Broca's region and deep hemisphere structural damage to the internal capsule and basal ganglia; (4) related to reduced functional motor performance, spontaneous speech, naming, reading, and writing; and (5) included all Broca's aphasia subjects.
authors: Veteran's Administration Medical Center, Sepulveda, CA 91343.
authors: E J
authors: EJ
authors: Metter
authors: D
authors: D
authors: Kempler
authors: C A
authors: CA
authors: Jackson
authors: W R
authors: WR
authors: Hanson
authors: W H
authors: WH
authors: Riege
authors: L R
authors: LR
authors: Camras
authors: J C
authors: JC
authors: Mazziotta
authors: M E
authors: ME
authors: Phelps
mesh_terms: D001037:Aphasia / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology; D001519:Behavior; D002531:Cerebellum / Q000378:metabolism*; D002908:Chronic Disease; D005121:Extremities / Q000503:physiopathology; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007802:Language; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D005947:Glucose