Lack of evidence for an impairment of tuberoinfundibolar dopaminergic neurons in aged male rats of the Sprague-Dawley strain.
Circulating prolactin (PRL) levels, dopamine (DA) content, in vitro basal and stimulus-evoked endogenous DA release from arcuate-periventricular nuclei median-eminence fragments were studied in young (4 months) and old (24-25 months) male rats of Sprague-Dawley strain. Serum PRL levels did not differ in young and aged animals. In addition DA tissue content, basal and K+- or d-amphetamine evoked endogenous DA release did not show age-related differences. These results suggest that in male rats of the Sprague-Dawley strain the activity of tuberoinfundibular dopaminergic (TIDA) neurons does not change during senescence, unlike what happens in other strains of rats.
Amoroso
S
S
Department of Pharmacology, 2nd School of Medicine, University of Naples, Italy.
Di Renzo
G F
GF
Maurano
F
F
Maida
P
P
Taglialatela
M
M
Annunziato
L
L
D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D011188:Potassium / Q000494:pharmacology; D011388:Prolactin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
D011388:Prolactin; D011188:Potassium; D003913:Dextroamphetamine; D004298:Dopamine