Study on the bioequivalence of two ranitidine formulations.
Two 150 mg ranitidine containing tablet formulations were administered to 10 healthy volunteers in order to examine the biological equivalence. The study considered the area under the curve as the most important parameter, and also the duration of suppression of the gastric acid to 50%, based on a threshold concentration of ranitidine in serum of 165 ng/ml. The evaluation of data by statistical means shows that the formulations are equivalent.
Hilgenstock
C
C
Instrumentelle Analytik, McKnight Laboratories GmbH, Hamburg, Fed. Rep. of Germany.
Schmiedel
G
G
Bührens
K G
KG
D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D011899:Ranitidine / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D013810:Therapeutic Equivalency
D011899:Ranitidine