title: Long-term complications of toxic epidermal necrolysis (Lyell's disease). Clinical and histopathologic study.
abstract: A case of toxic epidermal necrolysis had been observed in a 4-year-old child. This patient has been reexamined by us 21 years later. At that time a biopsy of conjunctival material and a histopathologic and ultrastructural study were done. The long-term ocular complications of the disease caused severe visual impairment with a remarkable sicca syndrome due to extensive scarring and keratinization, as confirmed also by light- and electron-microscopic features. These findings, concerning a particularly long follow-up, suggest that the ocular sequelae of this disease require continuous ophthalmological supervision many years after the acute stage of the disease.
authors: Eye Clinic, University of Milan, Ospedale San Paolo, Italy.
authors: G P
authors: GP
authors: de Felice
authors: R
authors: R
authors: Caroli
authors: A
authors: A
authors: Autelitano
mesh_terms: D000328:Adult; D003228:Conjunctiva / Q000473:pathology; D003229:Conjunctival Diseases / Q000209:etiology* / Q000473:pathology; D003315:Cornea / Q000473:pathology; D003316:Corneal Diseases / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000473:pathology