A nonmathematical view of mathematical models for cancer.
A qualitative view of mathematical models for cancer is presented. The Armitage and Doll multistage and Moolgavkar two-stage models of cancer are discussed in terms of their physical models. Time-related factors for these models as well as some of their characteristics are presented. The effect of age at first exposure, duration of exposure, time since last exposure and stage of carcinogenic effect on risk are detailed.
Chu
K C
KC
Division of Cancer Prevention and Control, National Cancer Institute, Bethesda, MD 20892.
D000367:Age Factors; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology*; D012307:Risk Factors; D013997:Time Factors