Urea treatment for water retention in hyponatremic congestive heart failure.
We have studied the efficiency of urea in the treatment of hyponatremia and hydrosaline retention in a 76-year-old man with chronic ischemic congestive heart failure. Since increase of furosemide worsened the hyponatremia (120 mmol/l), 30 g/day of urea was added and induced the following changes: progressive weight loss (6.5 kg in one week), increased diuresis (from 0.750 to 1.950 l/day), increased salt excretion (from 40 to 165 mmol sodium/day) and correction of the hyponatremia (120 to 136 mmol/l). Blood urea and creatinine serum concentrations rose moderately without significant change in creatinine clearance (32 to 38 ml/min). No adverse effects related to urea administration were observed. Urea intake seems to be useful in the management of hyponatremia in our patient with cardiac failure.
Cauchie
P
P
Department of Internal Medicine, University Hospital Erasme (ULB), Brussels, Belgium.
Vincken
W
W
Decaux
G
G
D000368:Aged; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000627:therapeutic use*; D006333:Heart Failure / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007010:Hyponatremia / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D014508:Urea / Q000627:therapeutic use*
D005665:Furosemide; D014508:Urea