Ca2+ releasing effect of perezone on adrenal cortex mitochondria.
Ca2+ energy-coupled transport was analized in adrenal cortex mitochondria using the sesquiterpenic drug perezone. Perezone promotes Ca2+ efflux by inducing collapse of the membrane potential and oxidation of pyridine nucleotides. The effect of perezone on mitochondrial Ca2+ release follows a dose-response relationship and is dependent of the reduction of the drug. These data suggest that perezone may produce a cytotoxic effect through an impairment in Ca2+ homeostasis.
Cuéllar
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Departamento de Bioquímica, Instituto Nacional de Cardiología, Ignacio Chávez, México, D.F.
Cárabez
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Chávez
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D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D008564:Membrane Potentials / Q000187:drug effects; D008928:Mitochondria / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D012717:Sesquiterpenes / Q000494:pharmacology*
D012717:Sesquiterpenes; D009243:NAD; D009249:NADP; C053752:perezone; D002118:Calcium