title: Immunologic cell markers of peripheral blood and lymph node lymphocytes in chronic lymphocytic leukemia.
abstract: The immunologic phenotype of the lymphocytes of 100 patients with chronic lymphocytic leukaemia (CLL) was investigated. Peripheral blood lymphocytes (PBL) were examined in all cases; in 46 patients with lymphadenopathy, a lymph node was biopsied and the histologic and immunologic patterns were assessed: 24 had a lymphocytic-lymphoplasmocytoid histology and 22 the follicular variant of lymphocytic lymphoma (mantle zone lymphoma, MZL). For comparison, lymph node suspensions from 19 patients with non-leukemic centrocytic lymphoma (CCL) were also studied. Significant differences in the PBL immunologic features were found between stage O and stage I patients. The phenotype of the lymphocytes of patients with lymphocytic histology was similar to that of stage 0 CLL patients, whereas major differences were found between these patients and those with mantle zone histology. This enables these patients to be recognized easily on immunologic grounds.
authors: Department of Haematology, San Giovanni Battista Regional Hospital, Molinette, Torino, Italy.
authors: L
authors: L
authors: Resegotti
authors: G
authors: G
authors: Palestro
authors: D
authors: D
authors: Novero
authors: F B
authors: FB
authors: Micca
authors: L
authors: L
authors: Godio
authors: M
authors: M
authors: Pistone
authors: M
authors: M
authors: Garnero
authors: A
authors: A
authors: Levis
authors: A
authors: A
authors: Stramignoni
mesh_terms: D000954:Antigens, Surface / Q000032:analysis; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D009367:Neoplasm Staging; D010641:Phenotype; D011947:Receptors, Antigen, B-Cell / Q000032:analysis
chemical_list: D000954:Antigens, Surface; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell