[Effect of hypoxic cell sensitizer metronidazole on the radiation reaction of clonogenic cells from solid tumors].
The clonogenic capacity of cells from peripheral and central zones of solid NKLy tumors of mice treated with metronidazole, a sensitizer of hypoxic cells, and with a mixture of metronidazole and radiation was studied by cloning in diffusion chambers. The cytotoxic effect of metronidazole was only noted during the prolonged interaction with cells under acute hypoxia that was observed in central tumor zones. Metronidazole increased by more than two times the radiosensitivity of cells from the central zones of the tumor and did not influence the radiation response of cells from the peripheral zones. Metronidazole was shown to inhibit the repair of potentially lethal radiation damages.
Gulverdashvili
N A
NA
Afanas'ev
G G
GG
Pelevina
I I
II
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D008795:Metronidazole / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D010100:Oxygen / Q000378:metabolism*; D011836:Radiation Tolerance; D014410:Tumor Stem Cell Assay
D008795:Metronidazole; D010100:Oxygen
Vliianie sensibilizatora gipoksicheskikh kletok metronidazola na radiatsionnuiu reaktsiiu klonogennykh kletok solidnykh opukholeĭ.