Sequence deduced physical properties in the D-loop region common to five vertebrate mitochondrial DNAs.
Some sequence-induced physical properties of the region of the replication origin in human, mouse, rat, ox and xenopus mitochondrial DNA have been studied: characteristic profiles of stability can be observed, a consensus pattern of hydrogen bond donor/acceptor associated to a symmetrical distribution of base roll angles variation is found upstream of the 5' ends of the D-loop strand. In spite of diversity, evolution has conserved the collective physical properties in parts of the origin of replication region suggesting specific functions for these non-coding sequences.
Mignotte
B
B
Laboratoire de Biologie Générale, Université de Paris-Sud, Orsay, France.
Dunon-Bluteau
D
D
Reiss
C
C
Mounolou
J C
JC
D000818:Animals; D001483:Base Sequence; D002417:Cattle; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004261:DNA Replication; D004272:DNA, Mitochondrial; D005815:Genetic Code; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D051381:Rats; D014981:Xenopus
D004272:DNA, Mitochondrial