Acquisition of a brief behavioural experience in the rat is inhibited by the brain-specific monoclonal antibody, F3-87-8.
Intraventricular infusion of the brain-specific monoclonal antibody F3-87-8 is demonstrated to inhibit the acquisition of a passive-avoidance paradigm in a rat model. Antibody was infused prior to, and following, training of a step-down task and recall was assessed after 24 and 48 h. The antibody only inhibited recall when infused prior to training and no effect was seen when administered 6 h after acquisition of the task. No effect was found with absorbed antibody or in sham-operated animals and open field studies showed no alterations in locomotor activity. Results are discussed considering available information on the antigen and current memory/learning theories.
Nolan
P M
PM
Department of Pharmacology, University College, Belfield, Dublin, Ireland.
Bell
R
R
Regan
C M
CM
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D000918:Antibody Specificity; D001362:Avoidance Learning / Q000502:physiology; D001921:Brain / Q000276:immunology / Q000502:physiology*; D007276:Injections, Intraventricular; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000276:immunology / Q000502:physiology
D000911:Antibodies, Monoclonal