Isolation and bioactivity of new tanshinones.
Two new diterpenoids, designated neocryptotanshinone and isotanshinone IIB, have been isolated from "Tan-Shen," the root of Salvia miltiorrhiza, together with a known compound, danshexinkun A. Their structures are established by spectral and physical data. Isotanshinone IIB exhibits significant inhibitory activity in vitro on ADP- and collagen-induced aggregation.
Lee
A R
AR
School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, R.O.C.
Wu
W L
WL
Chang
W L
WL
Lin
H C
HC
King
M L
ML
D045784:Abietanes; D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors; D003094:Collagen / Q000037:antagonists & inhibitors; D006801:Humans; D066298:In Vitro Techniques; D010616:Phenanthrenes / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis; D010974:Platelet Aggregation / Q000187:drug effects*
D045784:Abietanes; D010616:Phenanthrenes; C021751:tanshinone; D000244:Adenosine Diphosphate; D003094:Collagen