[Lattice structure antacids and antacid mixtures].
In the last years the importance of the evaluation of antacid compounds according to their neutralizing capacity decreased. Clinical investigations have shown that antacid mixtures of aluminum-magnesium hydroxide healed gastric an duodenal ulcers (neutralizing capacity 100-150 mmol/day) as well as H2 receptor antagonists and better than a placebo. By this the necessary daily dosage could be reduced essentially. This paper presents studies showing that lattice like structured antacids (e.g. Magaldrate) healed gastric and duodenal ulcers (neutralizing capacity 100-350 mmol/day) as well as Ranitidine (150 mg b.d.). Maintenance therapy should be evaluated critically because sufficient data are not available and mineral metabolism is changed significantly by extremely small dosages of aluminium-magnesium hydroxide antacids even in patients with normal kidney function.
Miederer
S E
SE
Medizinische Klinik des Ev. Johannes Krankenhauses Bielefeld.
Schmidt
C
C
D000536:Aluminum Hydroxide / Q000627:therapeutic use; D000863:Antacids / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000188:drug therapy; D005745:Gastric Acidity Determination; D006801:Humans; D008276:Magnesium Hydroxide / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000188:drug therapy*; D011899:Ranitidine / Q000627:therapeutic use; D012008:Recurrence; D013329:Structure-Activity Relationship; D014945:Wound Healing / Q000187:drug effects
D000863:Antacids; D000536:Aluminum Hydroxide; C016545:magaldrate; D011899:Ranitidine; D008276:Magnesium Hydroxide
Gitterförmige Antazida und Antazidagemische.