title: Methotrexate neuroenteropathy--a histochemical study.
abstract: 10 mg/kg Methotrexate was injected daily for 5 d a week for a total period of 3 weeks and its effect on autonomic nerve profiles of jejunum was studied using histochemical methods. Initially (after 5 doses in a week) partial degeneration of adrenergic and cholinergic nerve supply was observed. Prolonged treatment (15 does in 3 weeks) was responsible for disappearance of about 30% of adrenergic and 50% of cholinergic nerve profiles. Early degenerative changes in the cholinergic nerve cells of the intestinal plexuses was also noted.
authors: Department of Anatomy, College of Medicine, Riyadh, Saudi Arabia.
authors: M G
authors: MG
authors: el-Badawi
authors: J A
authors: JA
authors: Fatani
authors: M A
authors: MA
authors: Qayyum
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000320:Adrenergic Fibers / Q000187:drug effects; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D002799:Cholinergic Fibers / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007583:Jejunum / Q000294:innervation*; D008727:Methotrexate / Q000633:toxicity*; D008856:Microscopy, Fluorescence; D009410:Nerve Degeneration / Q000187:drug effects*
chemical_list: D000110:Acetylcholinesterase; D008727:Methotrexate