Transvenous coronary angiography in dogs using synchrotron radiation.
The application of coronary angiography is limited because it requires arterial invasion and the direct injection of contrast agent into the coronary arteries. A prototype system has been developed which achieves sufficient sensitivity to the iodinated contrast agent to allow the visualization of coronary arteries in dogs after its intravenous injection. The system uses two fan beams of x-rays from an electron storage ring and a 300 element linear silicon detector. Two interlaced images, spaced at 150 eV above and below the K absorption edge of iodine (33.2 keV), are acquired and the logarithmic subtraction of these two images produces an image which has maximal sensitivity to iodine and minimal sensitivity to soft tissue and bone. This approach appears suitable for studies on human subjects.
Thompson
A C
AC
Lawrence Berkely Laboratory, Berkeley, California.
Zeman
H D
HD
Otis
J N
JN
Hofstadter
R
R
Rubenstein
E
E
Harrison
D C
DC
Kernoff
R S
RS
Giacomini
J C
JC
Gordon
H J
HJ
Brown
G S
GS
D000792:Angiography / Q000379:methods*; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D017023:Coronary Angiography; D003973:Diatrizoate / Q000008:administration & dosage; D003974:Diatrizoate Meglumine / Q000008:administration & dosage; D004285:Dogs; D004338:Drug Combinations / Q000008:administration & dosage; D007275:Injections, Intravenous; D010315:Particle Accelerators
D003287:Contrast Media; D004338:Drug Combinations; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; C027278:urovision