[Role of multipolar mitoses in the proliferation of multinucleate cells induced by cytochalasin B].
A prolonged action of cytochalasin B results in the formation of numerous multipolar mitoses (26%) in Chinese hamster cell cultures. The transition to multipolar mitoses in the presence of cytochalasin B is not accompanied by K-mitotic delay. It is shown that a multipolar mitosis without cytoplasmic division is one of the main causes of multinucleation development in cytochalasin B-treated cultures. After stopping the drug action the cytochalasin B-induced multinucleate cells continue to divide by multipolar mitosis. In this case it completes with cytokinesis and, probably, leads to a decrease in the number of nuclei per cell. The origin of multipolar mitotic apparatus after the action of cytochalasin B is discussed in addition to the role of multipolar mitosis in formation and proliferation of multinucleate cells.
Petrashchuk
O M
OM
Onishchenko
G E
GE
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects*; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D003571:Cytochalasin B / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects*; D013997:Time Factors
D003571:Cytochalasin B
Issledovanie roli mnogopoliusnykh mitozov v proliferatsii mnogoiadernykh kletok, indutsirovannykh tsitokhalazinom B.