Premenopausal osteoporosis associated with vitamin D-responsive calcium malabsorption. A case report.
A premenopausal woman with severe osteoporosis was found to have impaired calcium absorption, without other evidence of intestinal malabsorption. Although circulating levels of 25-OH-vitamin D and 1,25-(OH)2-vitamin D were normal, calcium absorption improved markedly following two weeks of treatment with synthetic 1,25-(OH)2-vitamin D. This suggests that a partial intestinal resistance to the actions of 1,25-(OH)2-vitamin D contributed to the development of her osteoporosis. This case report demonstrates the feasibility of using the calciuric response to a standard oral calcium load to screen for impaired calcium absorption in osteoporotic patients.
Glauber
H S
HS
Department of Medicine, Veterans Administration Medical Center, San Diego, California 92161.
Catherwood
B D
BD
D000328:Adult; D002117:Calcitriol / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism*; D004100:Dihydroxycholecalciferols / Q000378:metabolism; D005260:Female; D006801:Humans; D008286:Malabsorption Syndromes / Q000150:complications* / Q000188:drug therapy; D008593:Menopause; D009942:Organometallic Compounds / Q000627:therapeutic use; D010024:Osteoporosis / Q000209:etiology* / Q000378:metabolism; D014312:Trisaccharides / Q000627:therapeutic use
D004100:Dihydroxycholecalciferols; D009942:Organometallic Compounds; D014312:Trisaccharides; C042131:calcium glubionate; D002117:Calcitriol; D002118:Calcium