title: Individual clones of hemopoietic cells in murine long-term bone marrow culture.
abstract: Forty-seven individual hemopoietic cell clones bearing unique radiation markers were studied in long-term bone marrow cultures. Throughout cultivation clones appeared at different times, from 1 to 12 weeks after explantation, survived during 1-10 more weeks, and were characterized by marked variability in size. Usually, the number of metaphases peculiar to an individual clone rapidly increased, achieved maximum, and then underwent a decline. Cells of reliably disappearing clones were never seen again. The experimental results provide further evidence for the model of hemopoiesis by clonal succession.
authors: Central Institute of Hematology and Blood Transfusion, Moscow, U.S.S.R.
authors: J L
authors: JL
authors: Chertkov
authors: E I
authors: EI
authors: Deryugina
authors: N J
authors: NJ
authors: Drize
authors: G A
authors: GA
authors: Udalov
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D002453:Cell Cycle; D002478:Cells, Cultured; D002999:Clone Cells; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000528:radiation effects; D008677:Metaphase; D051379:Mice; D011839:Radiation, Ionizing