Malignant hyperpyrexia and isoflurane. A case report.
Malignant hyperpyrexia developed, and was successfully treated, in a 50-year old man undergoing pyelolithotomy. Early diagnosis with the assistance of end-tidal carbon dioxide monitoring facilitated prompt treatment with i.v. dantrolene. A positive muscle biopsy subsequently confirmed the diagnosis. The only likely triggering agent used was isoflurane.
Thomas
D W
DW
Department of Anaesthetics, Morriston Hospital, Cwmrhydyceirw, Swansea.
Dev
V J
VJ
Whitehead
M J
MJ
D000769:Anesthesia, Inhalation / Q000009:adverse effects*; D003620:Dantrolene / Q000627:therapeutic use; D006801:Humans; D007431:Intraoperative Complications / Q000209:etiology; D007530:Isoflurane / Q000009:adverse effects*; D008297:Male; D008305:Malignant Hyperthermia / Q000188:drug therapy / Q000209:etiology*; D008875:Middle Aged
D007530:Isoflurane; D003620:Dantrolene