A study on the effect of a single dose of tamoxifen on uterine hyperaemia and growth in the rat.
1 The effect of a single subcutaneous dose of tamoxifen on the rat uterotrophic response was investigated. 2 The parameters examined were uterine blood flow (measured by the microsphere technique), uterine wet and dry weights and the concentrations of cytosolic and nuclear oestrogen receptors. 3 Tamoxifen or its metabolites proved to be capable of eliciting a uterotrophic response of 35-42 days duration. The changes seen in uterine blood flow and weight are discussed in relation to oestrogen receptor distribution.
Marshall
K
K
Postgraduate School of Studies in Pharmacology, University of Bradford, West Yorkshire.
Senior
J
J
D000818:Animals; D001834:Body Water / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D005260:Female; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011960:Receptors, Estrogen / Q000378:metabolism; D012039:Regional Blood Flow / Q000187:drug effects; D013629:Tamoxifen / Q000494:pharmacology*; D014599:Uterus / Q000098:blood supply* / Q000254:growth & development
D011960:Receptors, Estrogen; D013629:Tamoxifen