title: Theophylline clearance during and after mild upper respiratory infection.
abstract: Theophylline clearance was estimated by a single-sample technique in 19 subjects with acute clinical respiratory infections. Mean (+/- SD) theophylline clearance during acute illness was 0.044 +/- 0.011 L X h-1 X kg-1 compared to 0.043 +/- 0.012 L X h-1 X kg-1 1 month later. In a subset of five subjects, single-sample clearance estimates were not different from standard multi-sample clearance estimates. Mild upper respiratory infection does not appear to alter theophylline clearance in adults.
authors: Department of Pharmacology, University of Toledo College of Pharmacy, Ohio 43606.
authors: K
authors: K
authors: Bachmann
authors: J
authors: J
authors: Schwartz
authors: M
authors: M
authors: Martin
authors: L
authors: L
authors: Jauregui
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000378:metabolism*; D013806:Theophylline / Q000493:pharmacokinetics*
chemical_list: D013806:Theophylline