title: Evaluation of the effect of a platelet activating factor antagonist on platelet activating factor and Ascaris antigen-induced airway responses in rhesus monkeys.
abstract: An acute airway response to aerosolized platelet activating factor (PAF) can be induced in certain rhesus monkeys. This PAF airway response is completely inhibited by the PAF antagonist, SRI 63-441, in normal monkeys. After the completion of these studies showing inhibition of the PAF airway response, we evaluated whether the PAF antagonist could inhibit three types of acute IgE-mediated airway responses to Ascaris suum (A) in rhesus monkeys. The A aerosol test protocols used the following: a single A aerosol challenge system; a threshold dose of A challenge system, which consists of increasing A aerosol exposure until an airway response occurs; and two sequential A challenges in which the response to the second A challenge always occurs if there is a response to the first A challenge. When SRI 63-441 was tested as a potential antagonist of the A airway response in any of these three systems, no inhibition was shown.
authors: Department of Medicine, Northwestern University Medical School, Chicago, IL 60611.
authors: R
authors: R
authors: Patterson
authors: K E
authors: KE
authors: Harris
authors: D A
authors: DA
authors: Handley
authors: R N
authors: RN
authors: Saunders
mesh_terms: D000336:Aerosols; D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D001200:Ascaris / Q000276:immunology*; D005260:Female; D008168:Lung / Q000276:immunology* / Q000502:physiology; D008253:Macaca mulatta; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D011806:Quinolinium Compounds / Q000494:pharmacology*; D012129:Respiratory Function Tests
chemical_list: D000336:Aerosols; D000947:Antigens, Helminth; D010972:Platelet Activating Factor; D011806:Quinolinium Compounds; C050531:SRI 63-441