Mixed actions of hemicholinium at autonomic receptor sites of the rat vas deferens.
1. The effects of hemicholinium (HC-3) on several autonomic agents in the isolated rat vas deferens were investigated. 2. HC-3 reduced slightly the effects of NE and DA. 3. The responses by cholinergic agents on the M1-ACh receptors were not modified, however HC-3 reduced, significantly, the responses on the M2-ACh receptors. 4. These results suggest that HC-3 besides its anticholinergic properties possesses ability to interact with adrenoceptors in the isolated rat vas deferens.
Miranda
H F
HF
Department of Pharmacology, School of Medicine, Universidad Central del Caribe, Cayey, PR.
Santacana
G E
GE
Wolstenholme
W W
WW
Moreu
G M
GM
D000818:Animals; D001337:Autonomic Agents / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology; D004558:Electric Stimulation; D006426:Hemicholinium 3 / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects*; D011950:Receptors, Cholinergic / Q000187:drug effects*
D001337:Autonomic Agents; D010277:Parasympathomimetics; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D006426:Hemicholinium 3; D004298:Dopamine; D009638:Norepinephrine