title: Biliary penetration of cefbuperazone in the presence and absence of obstructive jaundice.
abstract: In thirteen patients with normal liver function, the mean concentrations of cefbuperazone in hepatic bile, gall bladder bile and gallbladder tissue 30 min after injection were 1134.8 +/- 36.8 (mean +/- S.E.M.) mg/l, 6.6 +/- 3.0 mg/l and 26.1 +/- 7.6 mg/l, respectively. In patients with obstructive jaundice, cefbuperazone concentrations in bile were 99 +/- 29.2 mg/l (mean +/- S.E.M.) 1 h post-dose and decreased to 13.9 +/- 5.1 mg/l 6 h post-dose. In both groups of patients biliary concentrations of cefbuperazone were higher than the MICs of most organisms causing biliary infection.
authors: First Department of Surgery, Osaka City University Medical School, Japan.
authors: H
authors: H
authors: Tanaka
authors: H
authors: H
authors: Nishino
authors: T
authors: T
authors: Sawada
authors: N
authors: N
authors: Kawaguchi
authors: T
authors: T
authors: Azuma
authors: Y
authors: Y
authors: Yoshii
authors: K
authors: K
authors: Satake
mesh_terms: D001646:Bile / Q000032:analysis; D001659:Biliary Tract / Q000378:metabolism*; D001692:Biological Transport; D002513:Cephamycins / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002779:Cholestasis / Q000188:drug therapy / Q000378:metabolism*; D005704:Gallbladder / Q000032:analysis; D006801:Humans
chemical_list: D002513:Cephamycins; C035978:cefbuperazone