Pharmacological studies of water extract of the Zizyphus seed and the Zizyphus seed containing drug.
1. The pharmacological properties of a water extract of the Zizyphus seed (HO2) and that of the Zizyphus seed containing drug (HO1) were studied. 2. After oral or intraduodenal administration of 3 g/kg of HO1 or HO2, the hypnotic effects induced by hexobarbital-Na (38 mg/kg, i.p.) and diazepam-induced sleep in mice were potentiated. 3. After oral or intraduodenal administration of 3 g/kg of HO1 or HO2, gastric juice secretion and ulcers induced by water immersion stress, histamine and reserpine in rats were inhibited.
Morishita
S
S
Research Laboratories, Kyushin Pharmaceutical Co. Ltd, Tokyo, Japan.
Mishima
Y
Y
Hirai
Y
Y
Saito
T
T
Shoji
M
M
D000700:Analgesics; D000818:Animals; D000897:Anti-Ulcer Agents; D001831:Body Temperature / Q000187:drug effects; D004357:Drug Synergism; D005750:Gastric Juice / Q000378:metabolism; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects
D000700:Analgesics; D000897:Anti-Ulcer Agents; D010936:Plant Extracts