Effect of phytic acid on colonic epithelial cell proliferation.
Cell proliferation was studied in descending, transverse and ascending colonic crypts of rats fed either 0%, 0.6%, 1.2% or 2.0% phytic acid (PA). Significant effects of phytic acid were seen only in the descending colon. No changes in crypt height were observed. Both the 1.2 and 2.0% phytic acid groups exhibited significantly lower uppermost labelled cells than the control group. Animals given 1.2% and 2.0% phytic acid also showed significantly reduced DNA synthetic cells, as indicated by lower labelling indices.
Nielsen
B K
BK
Department of Nutritional Sciences, University of Toronto, Ontario, Canada.
Thompson
L U
LU
Bird
R P
RP
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D003106:Colon / Q000166:cytology*; D004247:DNA / Q000096:biosynthesis; D004847:Epithelial Cells; D007413:Intestinal Mucosa / Q000166:cytology*; D008297:Male; D010833:Phytic Acid / Q000494:pharmacology*; D051381:Rats
D010833:Phytic Acid; D004247:DNA