[Stabilizing effect of hydroxybenzimidazole and its derivatives on biological membranes during activation of lipid peroxidation].
Inhibition of lipid peroxidation (LPO) by oxybenzimidazole (OBI) and its derivatives--alkyloxybenzimidazole (AOBI) and alkylethoxybenzimidazole (AEBI) was studied in liver microsomes and brain synaptosomes. It has been shown that both OBI and AOBI strongly inhibit LPO in microsomes and not synaptosomes. AEBI failed to inhibit LPO in microsomes. AOBI is more potent than OBI both in ascorbate- and NADPH-dependent LPO of microsomes. An antioxidant effect of both compounds is more marked in ascorbate-dependent LPO. The investigation of the possible use of AOBI for the protection of liver membranes in various pathological conditions associated with LPO activation seems promising.
Bakalova
R
R
Davitashvili
N G
NG
Stoliarova
L G
LG
Smirnov
L D
LD
Erin
A N
AN
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D007425:Intracellular Membranes / Q000187:drug effects*; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects
D001562:Benzimidazoles; D008054:Lipid Peroxides; D008563:Membrane Lipids
Stabiliziruiushchee deĭstvie oksibenzimidazola i ego proizvodnykh na biologicheskie membrany pri aktivatsii perekisnogo okisleniia lipidov.