Influence of peripherally-administered peptides on ethanol-induced gastric ulcers in the rat.
1. Subcutaneous administration of bombesin (50-200 micrograms/kg), cholecystokinin-8 (10-100 micrograms/kg) and epidermal growth factor (10-100 micrograms/kg) but not calcitonin gene-related peptide (25 micrograms/kg), neurotensin (500 micrograms/kg) or substance P (200 micrograms/kg) produced a marked and dose-related inhibition of ethanol-induced gastric lesions in rats. 2. These actions were inhibited by a non-ulcerogenic dose of indomethacin suggesting that prostaglandins are involved in the protective activity of bombesin, cholecystokinin-8 and epidermal growth factor.
Evangelista
S
S
Pharmacology Department, A. Menarini Pharmaceuticals, Firenze, Italia.
Maggi
C A
CA
Meli
A
A
D000818:Animals; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000633:toxicity*; D007213:Indomethacin / Q000633:toxicity; D007279:Injections, Subcutaneous; D008297:Male; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000517:prevention & control
D010455:Peptides; D000431:Ethanol; D007213:Indomethacin