[Changes in erythrocyte volume in relation to characteristics of protein phosphorylation of the membrane cytoskeleton in hypertension: role of protein kinase C].
Shape, volume and protein phosphorylation of RBC were studied in normal subjects and patients with essential hypertension. Mean volume of RBC of hypertensive patients was reduced by 3-4%, as compared to the control group. The level of band 4.9 phosphorylation was simultaneously increased in RBC of hypertensive patients. Activation of protein kinase C with phorbol ester produced volume reduction and shape changes in RBC. These changes are accompanied with phosphorylation of bands 4.1 and 4.9. It is suggested that RBC volume reduction in essential hypertension may be related to an alteration in the regulation of cytoskeleton proteins phosphorylation.
Postnov
Iu V
IuV
Kravtsov
G M
GM
Kotelevtsev
Iu V
IuV
Dulin
N O
NO
Postnov
I Iu
IIu
D004789:Enzyme Activation; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004913:Erythrocytes, Abnormal / Q000648:ultrastructure*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D010085:Oxidative Phosphorylation; D011493:Protein Kinase C / Q000097:blood*
D008565:Membrane Proteins; D011493:Protein Kinase C
Izmenenie ob'ema éritrotsitov v sviazi s osobennostiami fosforilirovaniia belkov membrannogo tsitoskeleta pri gipertonicheskoĭ bolezni: rol' proteinkinazy C.