Coloradocin, an antibiotic from a new Actinoplanes. I. Taxonomy, fermentation and biological properties.
Coloradocin was discovered in a screen for anti-anaerobe activity. The producing organism was determined to be a new species of Actinoplanes, designated Actinoplanes coloradoensis sp. nov. Coloradocin inhibits Bacteroides, Clostridium and other anaerobes. It does not inhibit most aerobic bacteria but is effective against Neisseria gonorrhoeae and Haemophilus influenzae. Coloradocin has low acute toxicity.
Jackson
M
M
Anti-Infective Research Division, Abbott Laboratories, North Chicago, Illinois.
Karwowski
J P
JP
Theriault
R J
RJ
Fernandes
P B
PB
Semon
R C
RC
Kohl
W L
WL
D000192:Actinomycetales / Q000145:classification* / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D007783:Lactones; D051379:Mice
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D007783:Lactones; C047328:luminamicin