Theoretical model for the post-transcriptional regulation of the human c-myc gene expression, involving double-stranded RNA processing.
We propose that the human c-myc gene expression is regulated by a post-transcriptional mechanism based on the formation of a hairpin structure between c-myc mRNA exons 1 and 2. This structure could be rapidly processed by a hypothetical double stranded RNAse, removing the 5' end segment of the c-myc mRNA having the cap site. Removal of cap should propitiate exonucleolytic degradation of transcript.
Gariglio
P
P
Department of Genetics and Molecular Biology, CINVESTAV-IPN, Mexico, D.F.
del Angel
R
R
Herrera
A
A
Bonilla
M
M
D005784:Gene Amplification; D005786:Gene Expression Regulation; D006801:Humans; D008957:Models, Genetic; D009857:Oncogenes; D014176:Protein Biosynthesis; D012323:RNA Processing, Post-Transcriptional; D012330:RNA, Double-Stranded / Q000235:genetics*; D014158:Transcription, Genetic; D014178:Translocation, Genetic
D012330:RNA, Double-Stranded