title: 13-week subchronic toxicity study with morpholine oleic acid salt administered to B6C3F1 mice.
abstract: The effect of subchronic administration of morpholine oleic acid salt (MOAS) was studied in B6C3F1 mice. The dose levels of MOAS used were 0%, 0.15%, 0.3%, 0.6%, 1.25%, and 2.5% in drinking water. Reduced weight gains were noted in both sexes in the 2.5% group as compared to controls, but reductions were not significant. Water consumption values showed a dose-related tendency for a decrease in both females and males. Urine analysis showed significant elevation of specific gravity in the males in the 0.6%, 1.25%, and 2.5% groups and the females in the 1.25% and 2.5% groups. Significant elevation of plasma urea nitrogen was observed in males of the 1.25% and 2.5% groups and in females of the 0.6%, 1.25%, and 2.5% groups. The relative weight of the kidneys showed a dose-dependent increase that was statistically significant for the 1.25% and 2.5% MOAS groups in both sexes. Except for cloudy swelling of the proximal tubules of the kidneys in mice on the 2.5% regimen, no treatment-related histopathological alterations were observed in organs of either sex.
authors: First Department of Pathology, Nagoya City University Medical School, Japan.
authors: M
authors: M
authors: Shibata
authors: Y
authors: Y
authors: Kurata
authors: S
authors: S
authors: Tamano
authors: T
authors: T
authors: Ogiso
authors: S
authors: S
authors: Fukushima
authors: N
authors: N
authors: Ito
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney / Q000033:anatomy & histology; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D051379:Mice; D009025:Morpholines / Q000633:toxicity*; D019301:Oleic Acid; D009829:Oleic Acids / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects
chemical_list: D009025:Morpholines; D009829:Oleic Acids; D019301:Oleic Acid