[A case of carcinoma in the lower abdomen treated successfully with oral administration of bestrabucil].
A 72-year-old female was admitted because of a palpable hard tumor, 15 X 7 cm in size, in the left lower quadrant of the abdomen. According to a diagnosis of retroperitoneal tumor, laparotomy was performed, revealing a large tumor extending between the descending colon and the pelvic cavity, which could not be separated from the retroperitoneum, uterus, left ovary, urinary bladder or rectum. A number of metastatic nodules were disseminated to the peritoneum and mesenterium. The pathological diagnosis of the nodules was poorly differentiated carcinoma of transitional cell type, origin unknown. After discharge, oral administration of bestrabucil (100-200 mg/day), the benzoate of an estradiol-chlorambucil conjugate, was given to the patient at an outpatient clinic. The tumor ceased to be palpable when the total amount administered reached at 14 g. Ultrasonography and computed tomography demonstrated significant reduction in tumor size. A decrease in the peripheral leukocyte count was observed after every consecutive administration and it took about 2 months to recover to the normal level. No other side effects were observed in this case. Although administration was stopped at a total amount of 16.1 g, reenlargement of the tumor has not been observed for 9 months.
Tsujitani
S
S
2nd Dept. of Surgery, Faculty of Medicine, Kyushu University.
Baba
H
H
Korenaga
D
D
Haraguchi
M
M
Hiramoto
Y
Y
Okamura
T
T
Sugimachi
K
K
D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000556:secondary; D002699:Chlorambucil / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004958:Estradiol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D010386:Pelvic Neoplasms / Q000556:secondary; D011379:Prognosis; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy*
D002699:Chlorambucil; D004958:Estradiol; C036613:bestrabucil