Markedly reduced blood pressure responsiveness in endotoxemic rats; reversal by neuropeptide Y.
This study in conscious normotensive rats was performed to assess the effect of the vasoconstrictor peptide, neuropeptide Y (NPY), on blood pressure responsiveness to exogenous norepinephrine in endotoxaemia. NPY and endotoxin were infused at doses which had no effect on blood pressure, whether given alone or in combination. Endotoxin markedly reduced the pressor responses to bolus injections of norepinephrine. However, blood pressure responsiveness could be enhanced by infusing NPY simultaneously with the endotoxin. It is suggested that low dose NPY infusions may be clinically useful in reversing the reduced vascular responsiveness to pressor amines in shock.
Evéquoz
D
D
Division of Hypertension, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Waeber
B
B
Corder
R
R
Nussberger
J
J
Gaillard
R
R
Brunner
H R
HR
D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000494:pharmacology; D007262:Infusions, Intravenous; D008297:Male; D009478:Neuropeptide Y / Q000097:blood / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D018805:Sepsis / Q000188:drug therapy
D004731:Endotoxins; D009478:Neuropeptide Y; C044101:endotoxin, Escherichia coli; D009638:Norepinephrine