Antithrombotic effect of indobufen in an experimental model of arterio-arterial microanastomosis in the rat.
Using an end-to-side microanastomosis of the left common carotid into the right common carotid of rats, implementing a potentially thrombogenic situation, we have investigated the possible antithrombotic effect of indobufen, a new antiplatelet drug. In eight of 15 untreated rats the anastomosis was totally obstructed by a single thrombus growing from the anastomotic wall. Indobufen treatment prevented thrombus formation completely in 14 of 15 rats (p less than 0.02). In treated animals indobufen also produced a statistically significant reduction of ADP-induced platelet aggregation relative to basal values. Platelet count were not influenced by drug treatment. Our experimental results suggest the potential usefulness of indobufen as an antithrombotic agent.
Carrieri
P
P
Institute of Clinical Neurology, Second Faculty of Medicine and Surgery, University of Naples, Italy.
Donzelli
R
R
Orefice
G
G
Cerillo
A
A
Volpentesta
G
G
Tayana
G
G
D000714:Anastomosis, Surgical; D000818:Animals; D002339:Carotid Arteries / Q000473:pathology / Q000601:surgery; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005343:Fibrinolytic Agents; D054833:Isoindoles; D008297:Male; D010654:Phenylbutyrates / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013927:Thrombosis / Q000097:blood / Q000473:pathology / Q000517:prevention & control*
D005343:Fibrinolytic Agents; D054833:Isoindoles; D010654:Phenylbutyrates; C020371:indobufen