[Mechanism of the anticancer action of selenium--influence on glycolysis and its key enzyme].
The aerobic glycolysis rate and mitochondria-bound hexokinase activity of ascitic liver cancer cells are 8 and 50 times as high as those of the normal liver cells, and they can be inhibited by Na2SeO3 in concentration below 10 micrograms/ml. The inhibitory effect increases with selenium concentration. In contrast, Na2SeO3 at the same concentration does not significantly affect the glycolysis rate and mitochondria-bound hexokinase activity of the normal liver cells. The selective action of selenium on energy metabolism of the liver cancer cells may account for its inhibitory effect on cancer cells.
Xia
X M
XM
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
Yu
S Y
SY
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006019:Glycolysis / Q000187:drug effects*; D006593:Hexokinase / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D008930:Mitochondria, Liver / Q000201:enzymology*; D020887:Selenious Acid; D012643:Selenium / Q000494:pharmacology*
D006593:Hexokinase; D020887:Selenious Acid; D012643:Selenium