Infrared spectroscopy of heparin-cation complexes.
Hydrated and partially hydrated films and aqueous solutions of heparin, heparans and N-desulphated preparations of these polymers were studied by near- and fundamental-region-i.r. spectroscopy in the presence of a range of countercations. The results suggest that ion binding is not explicable solely in terms of simple electrostatic theory, and that specific cation effects, and the hydration pattern of the polymer-cation complex need to be taken into account.
Grant
D
D
Department of Biochemistry, University of Aberdeen, Marischal College, U.K.
Long
W F
WF
Williamson
F B
FB
D002412:Cations / Q000378:metabolism*; D002594:Cetylpyridinium; D006493:Heparin / Q000378:metabolism*; D006497:Heparan Sulfate / Q000378:metabolism; D046911:Macromolecular Substances; D013055:Spectrophotometry, Infrared; D014867:Water
D002412:Cations; D002594:Cetylpyridinium; D006493:Heparin; D006497:Heparan Sulfate; D046911:Macromolecular Substances; D014867:Water