Enhanced growth of artificial tumor metastases following blood transfusion: the effect of erythrocytes, leukocytes and plasma transfusion.
Clinical and experimental investigations have shown that allogeneic blood transfusions may modulate the growth of tumors. Dependent on the tumor model used in animal studies, the effects observed ranged from inhibition to stimulation of tumor growth. We have demonstrated previously that allogeneic blood transfusions gave rise to enhanced growth of a transplantable sarcoma (LS 175) in BN rats. In the experiments reported here the effect of transfusion of different allogeneic blood constituents on the growth of artificial LS 175 lung metastases was investigated. Erythrocytes and leukocytes were found to promote tumor growth to a similar degree as whole blood transfusions, plasma transfusions had no effect.
Singh
S K
SK
Department of Surgery, Erasmus University, Rotterdam, The Netherlands.
Marquet
R L
RL
Westbroek
D L
DL
Jeekel
J
J
D000818:Animals; D001803:Blood Transfusion; D017707:Erythrocyte Transfusion; D017708:Leukocyte Transfusion; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D008297:Male; D014411:Neoplastic Stem Cells / Q000473:pathology; D010949:Plasma; D051381:Rats; D011914:Rats, Inbred BN; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000473:pathology / Q000556:secondary*; D014184:Transplantation, Homologous