Postoperative neuroleptic malignant syndrome. A case report.
A case of postoperative neuroleptic malignant syndrome is presented. A healthy 23-year-old male underwent a shoulder repair under uneventful fentanyl, halothane, nitrous oxide and oxygen anaesthesia. He received droperidol 5 mg IV and metoclopramide 10 mg IV intraoperatively to prevent postoperative nausea. Postoperatively, the patient developed autonomic instability, fever and generalized muscle rigidity. His level of consciousness was depressed. These findings were consistent with the diagnosis of neuroleptic malignant syndrome. The supportive treatment of the patient included active cooling measures, muscle relaxation and mechanical ventilation. The ability of anti-dopaminergic agents, including metoclopramide and droperidol, to precipitate the neuroleptic malignant syndrome is discussed. Treatment of the neuroleptic malignant syndrome is briefly discussed.
Patel
P
P
Department of Anaesthesia, University of Manitoba, Winnipeg.
Bristow
G
G
D000328:Adult; D017679:Cryotherapy; D003620:Dantrolene / Q000627:therapeutic use; D004329:Droperidol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology* / Q000628:therapy; D011183:Postoperative Complications / Q000209:etiology* / Q000628:therapy
D003620:Dantrolene; D004329:Droperidol