[Prevention of myocardial damage during reperfusion of the coronary artery in dogs using dibunol combined with verapamil].
An experimental study in 69 dogs examined the effect of isolated and combined use of dibunol and verapamil (isoptin) on the course of reperfusion of ischemized myocardium after 180 minutes' coronary occlusion. Verapamil alone had no protective effect on reperfused myocardium, whereas dibunol, and particularly its combination with verapamil, essentially limited the size of necrosis, reduced plasma CPK activity and animal mortality rate and maintained ultrastructural integrity of cardiomyocytes, which was accompanied by a decrease of plasma lipid peroxidation products and a stabilization of cardiomyocyte sarcolemma. The significance of membrane damage and uncontrolled calcium entrance into cardiomyocytes for the mechanism of myocardial damage at the recovery of coronary circulation is discussed.
Golikov
A P
AP
Pichugin
V V
VV
Konorev
E A
EA
Polumiskov
V Iu
VIu
Sharov
V G
VG
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage*; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000150:complications*; D003328:Coronary Thrombosis / Q000150:complications* / Q000188:drug therapy; D004285:Dogs; D004359:Drug Therapy, Combination; D009203:Myocardial Infarction / Q000209:etiology / Q000517:prevention & control*; D014700:Verapamil / Q000008:administration & dosage*
D000975:Antioxidants; D002084:Butylated Hydroxytoluene; D014700:Verapamil
Ogranichenie povrezhdeniia miokarda pri reperfuzii koronarnoĭ arterii u sobak s pomoshch'iu dibunola i ego kombinatsii s verapamilom.