Blockade of prostaglandin E1 hyperthermia by sodium salicylate given into the ventral septal area of the rat brain.
1. Sodium salicylate (30.0 micrograms microliter-1) or artificial cerebrospinal fluid (ACSF) was infused bilaterally into the ventral septal area (v.s.a.) of the unrestrained rat for 1 h before and 1 h after the injection of prostaglandin E1 at a concentration of 20.0 ng microliter-1 into a lateral cerebral ventricle. 2. During control (ACSF) infusions, 200.0 ng of prostaglandin E1 evoked a hyperthermic response (0.95 +/- 0.16 degrees C). During sodium salicylate infusions, the prostaglandin E1-evoked hyperthermia was significantly reduced (P less than 0.025) to 0.31 +/- 0.16 degrees C. 3. The fever index (degrees C h for 1.0 h) during the infusion of sodium salicylate was reduced 66% below that of control infusions (P less than 0.01). 4. These data indicate that sodium salicylate infused in the v.s.a. of rats can antagonize a prostaglandin E-evoked hyperthermia. This suggests that there may be an additional mechanism of action for sodium salicylate antipyresis other than inhibition of prostaglandin E synthesis.
Alexander
S J
SJ
Department of Medical Physiology, Faculty of Medicine, University of Calgary, Alberta, Canada.
Cooper
K E
KE
Veale
W L
WL
D000527:Alprostadil / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D003106:Colon / Q000502:physiology; D005334:Fever / Q000139:chemically induced*; D008297:Male; D051381:Rats; D012980:Sodium Salicylate / Q000494:pharmacology*; D013997:Time Factors
D000527:Alprostadil; D012980:Sodium Salicylate