Haptoglobin patterns in essential hypertension and associated conditions--increased risk for Hp 2-2.
Blood samples from 257 hypertensive patients and 180 normotensive controls were analysed for their association with haptoglobin levels and phenotypes. Compared to controls, patients with Hp 2-2 phenotype showed a significantly increased risk for essential hypertension (p less than 0.001) and hypertension associated with ischaemic heart disease (p less than 0.05). There was a significant decrease in the mean levels of serum haptoglobins in hypertension as compared to controls, suggesting the possibility for intravascular haemolysis due to vascular damage leading to further complications.
Surya Prabha
P
P
Department of Genetics, Osmania University, Hyderabad, India.
Padma
T
T
Ramaswamy
M
M
D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood; D006242:Haptoglobins / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications; D010641:Phenotype; D012306:Risk
D006242:Haptoglobins