[Development of combined inulin/p-aminohippuric acid (PAH) slow release implantation tablets for clearance determination in awake rats].
A new method has been developed for the simultaneous measurement of Inulin and PAH clearance in small laboratory animals (rats). An implantable Inulin/p-aminohippuric-acid matrix-retard tablet based on Eudragit was tested with the purpose to estimate renal clearances. Sufficiently high serum and urine levels of both substances can thus be maintained up to 12-48 hours. The advantage of the method is that it can be used for renal clearance tests in small conscious animals, able to move freely within their cages without serious handling stress.
Korsatko
W
W
Institut für Pharmazeutische Chemie, Karl-Franzens-Universität Graz, Osterreich.
Sadjak
A
A
Gall
P
P
Supanz
S
S
D000618:Aminohippuric Acids; D000818:Animals; D003692:Delayed-Action Preparations; D007444:Inulin; D007668:Kidney / Q000378:metabolism; D008657:Metabolic Clearance Rate; D051381:Rats; D010130:p-Aminohippuric Acid
D000618:Aminohippuric Acids; D003692:Delayed-Action Preparations; D007444:Inulin; D010130:p-Aminohippuric Acid
Entwicklung kombinierter Inulin/p-Aminohippursäure (PAH) Retard-Implantationstabletten zur Bestimmung der Clearance an wachen Ratten.