title: Propylene glycol pharmacokinetics and effects after intravenous infusion in humans.
abstract: Knowledge of the pharmacokinetics of propylene glycol (PG) is scarce, though it is used in a number of preparations for intravenous use. Although systemic toxicity appears to be uncommon, PG has been reported to cause lactic acidosis and other adverse effects. We describe a rapid gas chromatographic assay method for PG and the plasma pharmacokinetics after intravenous administration to six patients on nine occasions. The pharmacokinetics were nonlinear, based on a saturable clearance. The apparent first-order half-life was 2.3 +/- 0.7 h. There was no evidence of lactic acidosis, hemolysis, or increase in osmolality at 3-15 g/m2 PG infused over periods of 4 h.
authors: Department of Haematology, St. Radboud University Hospital, Nijmegen, The Netherlands.
authors: P A
authors: PA
authors: Speth
authors: T B
authors: TB
authors: Vree
authors: N F
authors: NF
authors: Neilen
authors: P H
authors: PH
authors: de Mulder
authors: D R
authors: DR
authors: Newell
authors: M E
authors: ME
authors: Gore
authors: B E
authors: BE
authors: de Pauw
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*
chemical_list: D011409:Propylene Glycols; D019946:Propylene Glycol