title: Pharmacokinetics of a single dose of rimantadine in young adults and children.
abstract: Single doses of rimantadine were given to children and young adults to evaluate the safety and pharmacokinetics of this antiviral compound. The half-life of rimantadine in young adults was 27.7 +/- 4.9 h for tablets and 27.8 +/- 8.0 h for syrup preparations. A total of 10 children, 5 to 8 years old, received a syrup preparation of rimantadine. The half-life of rimantadine in children was 24.8 +/- 9.4 h. A single dose of rimantadine was well tolerated in young adults and children.
authors: Department of Medicine, Marshall University School of Medicine, Huntington, West Virginia 25701.
authors: E L
authors: EL
authors: Anderson
authors: L P
authors: LP
authors: Van Voris
authors: J
authors: J
authors: Bartram
authors: H E
authors: HE
authors: Hoffman
authors: R B
authors: RB
authors: Belshe
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives*; D000284:Administration, Oral; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D011897:Random Allocation; D012299:Rimantadine / Q000008:administration & dosage / Q000378:metabolism*; D012996:Solutions; D013607:Tablets
chemical_list: D012996:Solutions; D013607:Tablets; D012299:Rimantadine; D000218:Adamantane