Pump-induced hemolysis in a rabbit model of neonatal ECMO.
There is no significant difference in hemolysis between pediatric centrifugal pumps and roller pumps during ECMO of 8 hours duration in rabbits or in comparable 24 hour isolated pump circuits. There is also no significant difference in heat production by either pump. Reports of severe hemolysis using the centrifugal pump in neonatal ECMO are likely due to other factors. Proper cannula selection and positioning are important measures to reduce hemolysis by minimizing circuit pressure and maximizing venous return. Avoidance of inadvertently high rotor speed in the centrifugal pump is also recommended.
Kress
D C
DC
Division of Cardiothoracic Surgery, University of Wisconsin Hospitals and Clinics, Madison.
Cohen
D J
DJ
Swanson
D K
DK
Hegge
J O
JO
Young
J W
JW
Watson
K M
KM
Rasmussen
P W
PW
Berkoff
H A
HA
D000328:Adult; D000818:Animals; D004195:Disease Models, Animal; D005112:Extracorporeal Circulation / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy; D009996:Osmotic Fragility; D010100:Oxygen / Q000097:blood*; D010976:Platelet Count; D011817:Rabbits
D006454:Hemoglobins; D010100:Oxygen