Brain vasoactive intestinal peptide: a potent stimulant of gastric acid secretion.
Vasoactive intestinal peptide (VIP) belongs to a rapidly expanding family of cerebrogastrointestinal oligopeptides. This report describes a potent dose-, time- and vagus-dependent stimulation of gastric acid secretion by brain VIP. Physiologic evidence favoring a role of VIP on acid secretion was provided by the finding that immunoneutralization of endogenous brain VIP produced a significant decrease of acid secretion. These and other data contained herein suggest that the mechanism by which central VIP stimulates acid secretion appears to involve peripheral cholinergic pathways.
Hernandez
D E
DE
North Carolina State University, School of Veterinary Medicine, Raleigh 27606.
Jennes
C
C
Emerick
S G
SG
D000818:Animals; D005744:Gastric Acid / Q000187:drug effects / Q000378:metabolism*; D007106:Immune Sera; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000378:metabolism / Q000502:physiology*; D014660:Vasoactive Intestinal Peptide / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*
D007106:Immune Sera; D014660:Vasoactive Intestinal Peptide