[The role of metabolic and regulatory factors in the mutagenic activity of purine derivatives in microorganisms].
The results concerning analysis of the mutagenic activity of analogues of nitrogen bases are given for Saccharomyces cerevisiae, Streptomyces antibioticus, Bacillus subtilis. The mutagenic activity of purine derivatives depends on their metabolic transformations in cell and on the activity of enzyme systems, involved in regulation of purine biosynthesis. The criterion of selection of purine analogues with genetic activity is proposed for yeasts, based on retroinhibitory ability of analogues of nitrogen bases.
Mikhaĭlova
N P
NP
Sorokoletova
E F
EF
Khromov-Borisov
N N
NN
Davidenkov
L R
LR
Ginak
A I
AI
D001419:Bacteria / Q000235:genetics* / Q000378:metabolism; D004269:DNA, Bacterial / Q000187:drug effects / Q000378:metabolism; D004271:DNA, Fungal / Q000187:drug effects / Q000378:metabolism; D009153:Mutagens / Q000493:pharmacokinetics; D009154:Mutation; D011687:Purines / Q000096:biosynthesis / Q000493:pharmacokinetics / Q000633:toxicity*; D015003:Yeasts / Q000235:genetics* / Q000378:metabolism
D004269:DNA, Bacterial; D004271:DNA, Fungal; D009153:Mutagens; D011687:Purines
Rol' metabolicheskikh i reguliatornykh faktorov v proiavlenii mutagennoĭ aktivnosti purinovykh proizvodnykh u mikroorganizmov.