N-acetyltransferase phenotype of patients with cancer of the larynx.
In the present paper N-acetyltransferase phenotype has been evaluated in 128 patients with cancer of the larynx. Out of 128 patients, 86.7% were smokers. The corresponding control group consisted of 106 men who did not suffer from neoplastic diseases. 83.6% of the patients were slow acetylators. This is significantly different from the frequency of 60.3% of slow acetylators observed in the control group. The slow acetylators exhibited a greater susceptibility to the cancer of the larynx.
Drózdz
M
M
Department of Biochemistry and Chemistry, Silesian Medical School, Katowice, Poland.
Gierek
T
T
Jendryczko
A
A
Pilch
J
J
Piekarska
J
J
D000107:Acetylation; D000123:Acetyltransferases / Q000235:genetics*; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000235:genetics; D006801:Humans; D007822:Laryngeal Neoplasms / Q000201:enzymology* / Q000235:genetics; D008875:Middle Aged; D010641:Phenotype; D012907:Smoking / Q000378:metabolism
D000123:Acetyltransferases