title: Primary structure and tissue distribution of guinea pig gastrin-releasing peptide.
abstract: The primary structure of gastrin-releasing peptide from the guinea pig stomach has been determined by automated Edman degradation and shown to be identical to porcine gastrin-releasing peptide. Extracts of guinea pig brain and small intestine contained both gastrin-releasing peptide and its COOH-terminal decapeptide (neuromedin C) but the stomach extracts contained only gastrin-releasing peptide. Within the small intestine, highest concentrations of gastrin-releasing peptide-like immunoreactivity were found in extracts of the circular and longitudinal smooth muscle layers.
authors: Clinical Research Group for Gastrointestinal Endocrinology of the Max-Planck-Gesellschaft, University of Göttingen, F.R.G.
authors: C
authors: C
authors: Shaw
authors: L
authors: L
authors: Thim
authors: J M
authors: JM
authors: Conlon
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001839:Bombesin / Q000032:analysis; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D019886:Gastrin-Releasing Peptide; D006168:Guinea Pigs; D007421:Intestine, Small / Q000032:analysis; D008297:Male; D010446:Peptide Fragments / Q000032:analysis; D010455:Peptides / Q000032:analysis*; D013270:Stomach / Q000032:analysis; D014018:Tissue Distribution
chemical_list: D000596:Amino Acids; D010446:Peptide Fragments; D010455:Peptides; D019886:Gastrin-Releasing Peptide; C040794:neuromedin C; D001839:Bombesin