title: Pathogenesis of membranous lipodystrophy. Case report and review of the literature.
abstract: Membranous lipodystrophy occurred in a 35-year-old woman and membrane-like material was found in her epiphyses and short bones. Electron microscopy allowed a study of the relationship between the pathologic tissue and normal fat, suggesting that the membrane-like material is derived from degenerated cells. Nucleation of hydroxyapatite crystals was also observed in the membranous material. Because basal ganglia calcifications were demonstrated with the use of computed tomography, brain and bone lesions may be assumed to share the same pathogenesis. Lipid and mucopolysaccharide metabolism was found to be normal.
authors: Clinica Ortopedica e Traumatologica dell'Università di Pavia ed I.R.C.C.S. Policlinico San Matteo, Italy.
authors: U E
authors: UE
authors: Pazzaglia
authors: F
authors: F
authors: Benazzo
authors: P D
authors: PD
authors: Byers
authors: L
authors: L
authors: Riboni
authors: L
authors: L
authors: Ceciliani
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism / Q000473:pathology; D000328:Adult; D001848:Bone Diseases, Developmental / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008060:Lipodystrophy / Q000378:metabolism* / Q000473:pathology; D011859:Radiography