[Experimental basis and clinical results of the use of short-term hyperglycemia in combined therapy of malignant tumors].
Proceeding from an analysis of the literature and their own data on radio- and thermodifying properties of hyperglycemia the authors have proposed a scheme of polyfactor therapy of malignant tumors including the following succession of exposures under clinical conditions: irradiation (the 1st fraction)--a chemotherapeutic drug--hyperglycemia--hyperthermia--irradiation (the 2nd fraction). The interval between exposures should be the least, best of all exposures should follow one another in a quick succession. Using the experimental data for determination of methods of therapy of transition and metastatic tumors of the upper respiratory tracts, satisfactory clinical results were obtained with regard to survival and the absence of local radiation reactions.
Dedenkov
A N
AN
Mardynskiĭ
Iu S
IuS
Ul'ianenko
S E
SE
Zubov
O G
OG
Salamatina
N A
NA
D001786:Blood Glucose / Q000378:metabolism*; D003131:Combined Modality Therapy; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D009369:Neoplasms / Q000097:blood / Q000532:radiotherapy / Q000628:therapy*; D011832:Radiation Injuries; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage; D013997:Time Factors
D001786:Blood Glucose; D005947:Glucose
Eksperimental'noe obosnovanie i klinicheskie rezul'taty primeneniia kratkovremennoĭ giperglikemii pri polifaktornoĭ terapii zlokachestvennykh opukholeĭ.