Alpha interferon in the treatment of symptomatic myelofibrosis with myeloid metaplasia.
2 patients with myelofibrosis and myeloid metaplasia had symptomatic splenomegaly and were treated with interferon alpha-2c (IFN alpha-2c). The splenic pain and pressure symptoms disappeared, accompanied by a decrease in the size of the spleen. However, the peripheral blood count worsened and no improvement in the bone marrow fibrosis could be observed.
Parmeggiani
L
L
Department of Haematology, University of Louvain, Brussels, Belgium.
Ferrant
A
A
Rodhain
J
J
Michaux
J L
JL
Sokal
G
G
D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010146:Pain; D055728:Primary Myelofibrosis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D013154:Spleen / Q000473:pathology / Q000503:physiopathology
D007370:Interferon Type I