Initiation, promotion and complete carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine or ethylnitrosourea in the Sencar mouse skin tumorigenesis model.
Five doses of either N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or ethylnitrosourea (ENU) were tested as complete carcinogens, tumor initiators and tumor promoters in the SENCAR skin tumorigenesis model. As tumor initiators, MNNG-induced papillomas at all doses tested, while ENU was active from 10-40 mumol. As complete carcinogens, MNNG from doses of 0.5-5.0 mumol and ENU from doses of 10 mumol-40 mumol were potent inducers of both papillomas and carcinomas indicating that these agents are active as both tumor initiators and tumor promoters.
O'Connell
J F
JF
University of Texas System Cancer Center, Science Park--Research Division, Smithville 78957.
Nesnow
S
S
Slaga
T J
TJ
D000818:Animals; D002273:Carcinogens; D002277:Carcinoma / Q000139:chemically induced; D003043:Cocarcinogenesis; D005038:Ethylnitrosourea / Q000494:pharmacology*; D005260:Female; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced*
D002273:Carcinogens; D008769:Methylnitronitrosoguanidine; D005038:Ethylnitrosourea