Action of some amides of substituted ethylenediamines on central nervous system.
Five of the substituted ethylenediamine amides (LMG I to V) were tested for various CNS attributes and for acute toxicity (24 hr mortality). All compounds were potent analgesics in various animal tests, LMG V being most potent. All reduced spontaneous activity of mice and potentiated ether anaesthesia. However, CAR was not altered and anti-MES were not pronounced in rats. Compounds appear to have a wide safety margin considering ED50 and LD50 in mice.
Sethi
O P
OP
Department of Pharmacology, L.M. College of Pharmacy, Navarangpura, Ahmedabad.
Ismail
A M
AM
Bhavsar
G C
GC
Trivedi
B M
BM
Gulati
O D
OD
D000577:Amides / Q000494:pharmacology / Q000633:toxicity; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D005029:Ethylenediamines / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012018:Reflex / Q000187:drug effects
D000577:Amides; D000700:Analgesics; D005029:Ethylenediamines; C031234:ethylenediamine