Distribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration.
The autopsy tissues concentration of amiodarone and desethylamiodarone of a man with acute myocardial infarction treated acutely with intravenous amiodarone is reported. Our data indicate that amiodarone is quickly distributed into all highly perfused tissues after intravenous administration with a high amiodarone/desethylamiodarone ratio. We also report here the autopsy case of a woman who died after 30 days of oral therapy with amiodarone. The increase in heart/plasma ratio of amiodarone and desethylamiodarone concentrations and the decrease in amiodarone/desethylamiodarone ratio after one month of therapy could explain the latency in the antiarrhythmic action of the drug.
Barbieri
E
E
Istituto Cardiologia e Chirurgia Cardiovascolare, Universita di Verona, Italy.
Latini
R
R
D'Aranno
V
V
Fabbri
A
A
Zampieri
P
P
Trevi
G P
GP
Zardini
P
P
D000638:Amiodarone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D014018:Tissue Distribution
C036116:desethylamiodarone; D000638:Amiodarone