title: High-grade mantle zone lymphoma.
abstract: A 66-year-old man with a 6-month history of sweating at night, generalized lymphadenopathy, hepatosplenomegaly, and paraproteinemia was diagnosed to have a Stage IV mantle zone lymphoma (MZL), which behaved aggressively. The neoplasm rapidly disseminated to extranodal sites--the skin, lungs, pleural cavity, and the central nervous system. The neoplasm did not respond to initial double-agent chemotherapy, but it did partially respond to multi-agent chemotherapy. In addition, the neoplasm had histopathologic features not reported previously in MZL--vascular invasion, massive extranodal infiltration, high mitotic count, and convoluted nuclei.
authors: University of Southern California, School of Medicine, Los Angeles 90033.
authors: D J
authors: DJ
authors: Ellison
authors: R R
authors: RR
authors: Turner
authors: R
authors: R
authors: Van Antwerp
authors: S E
authors: SE
authors: Martin
authors: B N
authors: BN
authors: Nathwani
mesh_terms: D000368:Aged; D006801:Humans; D008168:Lung / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D012867:Skin / Q000473:pathology