title: A preliminary study of desipramine in the treatment of cocaine abuse in methadone maintenance patients.
abstract: Intravenous cocaine use is a major problem in methadone maintenance programs. In this pilot study of 16 cocaine-abusing methadone maintenance patients, 8 received desipramine and 8 received no medication other than methadone. During an 8-week open trial the desipramine patients reported significantly less cocaine craving and had less cocaine use than the other patients.
authors: Substance Abuse Treatment Unit, Connecticut Mental Health Center, New Haven, CT.
authors: T R
authors: TR
authors: Kosten
authors: B
authors: B
authors: Schumann
authors: D
authors: D
authors: Wright
authors: M K
authors: MK
authors: Carney
authors: F H
authors: FH
authors: Gawin
mesh_terms: D000328:Adult; D001741:Black or African American; D000987:Antisocial Personality Disorder / Q000523:psychology; D003042:Cocaine; D003891:Desipramine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D009293:Opioid-Related Disorders / Q000150:complications / Q000534:rehabilitation*; D019966:Substance-Related Disorders / Q000150:complications / Q000188:drug therapy* / Q000534:rehabilitation
chemical_list: D003042:Cocaine; D003891:Desipramine; D008691:Methadone