title: Abnormal degradation of erythrocyte membrane proteins in hereditary spherocytosis.
abstract: The degradation rate of erythrocyte membrane proteins by membrane-bound proteases was compared in healthy controls and in patients with hereditary spherocytosis (HS). An increased degradation rate of spectrin and a decreased digestion rate of Band 3 were found in HS patients. These differences may be due to altered accessibilities of membrane proteins to proteases and/or to changes in the pattern of membrane-associated proteases and may be connected with the decrease in the spectrin: Band 3 ratio reported for erythrocyte membranes in HS.
authors: Laboratory of Biophysics of Development and Aging, University of Lódź, Poland.
authors: M
authors: M
authors: Gaczyńska
authors: G
authors: G
authors: Bartosz
authors: L
authors: L
authors: Judkiewicz
authors: J
authors: J
authors: Rosin
mesh_terms: D001798:Blood Proteins / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D013103:Spherocytosis, Hereditary / Q000097:blood*
chemical_list: D001798:Blood Proteins