title: Determination of metoprolol and two major metabolites in plasma and urine by column liquid chromatography and fluorometric detection.
abstract: Metoprolol and its alpha-hydroxy metabolite were determined in plasma down to 2 nmol/l (S.D. 10-15%) after solvent extraction and bonded-phase liquid chromatography with fluorometric detection. The major metabolite with a carboxylic function was also measured in plasma when liquid-solid extraction on a column activated with dodecyl sulphate was applied. In urine the three components were assayed by direct injection of a diluted sample.
authors: AB Hässle, Bioanalytical Chemistry, Mölndal, Sweden.
authors: K
authors: K
authors: Balmér
authors: Y Y
authors: YY
authors: Zhang
authors: P O
authors: PO
authors: Lagerström
authors: B A
authors: BA
authors: Persson
mesh_terms: D002853:Chromatography, Liquid; D006801:Humans; D007202:Indicators and Reagents; D008790:Metoprolol / Q000032:analysis* / Q000097:blood / Q000652:urine; D013050:Spectrometry, Fluorescence
chemical_list: D007202:Indicators and Reagents; D008790:Metoprolol