title: Phenotypic and genotypic heterogeneity in large granular lymphocyte expansion.
abstract: The cellular heterogeneity of large granular lymphocyte expansions has been illustrated by the phenotypic and genotypic findings in five patients. In one patient whose circulating cells were CD2+, CD3-, CD5-, CD7+, CD8-, CD11+, Leu7+, CD16+, and displayed strong natural killer activity, no rearrangement of the T cell receptor beta-chain gene and T cell rearranging gene gamma was detected. The four other patients presented with neutropenia without overt lymphocytosis. In these patients the circulating lymphocytes expressed a predominant T cell phenotype CD2+, CD3+, CD5+, CD7+, CD8+, Leu7+. In three of them the presence of a T cell clone was demonstrated on the basis of a unique pattern of rearrangement of the T cell receptor beta-chain genes.
authors: Unité INSERM U93, Paris, France.
authors: P
authors: P
authors: Loiseau
authors: M
authors: M
authors: Divine
authors: D
authors: D
authors: Le Paslier
authors: J P
authors: JP
authors: Marolleau
authors: J P
authors: JP
authors: Farcet
authors: G
authors: G
authors: Flandrin
authors: D
authors: D
authors: Cohen
authors: L
authors: L
authors: Degos
authors: F
authors: F
authors: Sigaux
authors: F
authors: F
authors: Reyes
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis*; D005260:Female; D005796:Genes; D006098:Granulocytes / Q000502:physiology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000502:physiology*; D007963:Leukocytes, Mononuclear / Q000502:physiology; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*
chemical_list: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D011948:Receptors, Antigen, T-Cell