Irisones A and B: two new isoflavones from Iris missouriensis.
Two new isoflavones, irisones A and B, together with the known compound, 5,7-dihydroxy-2',6-dimethoxy isoflavone, were isolated from the roots of Iris missouriensis. With the help of 2D-homonuclear-J-correlation and 2D-nOe experiments the structure of irisone A was deduced to be 5-hydroxy-2'-methoxy-6,7-methylenedioxy isoflavone. The structure of irisone B was elucidated by spectral analyses as 2',5-dihydroxy-6,7-methylenedioxy isoflavone and was confirmed by chemical conversion to irisone A.
Wong
S M
SM
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Illinois 60612.
Konno
C
C
Oshima
Y
Y
Pezzuto
J M
JM
Fong
H H
HH
Farnsworth
N R
NR
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids / Q000302:isolation & purification*; D007529:Isoflavones / Q000302:isolation & purification* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D010946:Plants, Medicinal / Q000032:analysis*
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D007529:Isoflavones; C053587:irisone A; C053588:irisone B