title: Nutritional availability to rats of selenium in four seafoods: crab (Callinectes sapidus), oyster (Crassostrea virginica), shrimp (Penaeus duorarum) and Baltic herring (Clupea harengus).
abstract: 1. The present study was conducted to determine the biological availability to rats of the selenium in four high-Se seafoods: crab (Callinectes sapidus), oyster (Crassostrea virginica), shrimp (Penaeus duorarum) and Baltic herring (Clupea harengus). 2. Weanling male rats were fed on a Se-deficient Torula yeast diet for 4 weeks followed by either continued depletion or repletion for 4 weeks with 0.05, 0.1 or 0.2 microgram Se as selenite/g, or 0.1 or 0.2 microgram Se as freeze-dried cooked test food/g. Plasma and liver Se levels or glutathione peroxidase (EC 1.11.1.9; GSH-Px) activities were used as indicators of body Se status. 3. Except for oysters, the biological availability of Se in all these seafoods was close to that of selenite (selenite 100%) when the criterion used was either plasma Se level or plasma GSH-Px activity. 4. By the criterion of increased liver Se level of restored hepatic GSH-Px activity, only herring-Se had a biological availability comparable to that of selenite-Se under all conditions tested, whereas crab-Se and oyster-Se were distinctly inferior in this regard. 5. Increasing the amount of crab-Se, oyster-Se or shrimp-Se supplied in the diet from 0.1 to 0.2 microgram/g changed the apparent availability (%) of Se for hepatic GSH-Px restoration from 38 to 78, 22 to 53 and 57 to 90 respectively. 6. The present study demonstrates that the availability of Se in certain foods is a function of the criterion chosen, the level of Se supplied in the diet, and possibly other unknown interacting dietary factors.
authors: Department of Nutrition, University of Helsinki, Finland.
authors: M
authors: M
authors: Mutanen
authors: P
authors: P
authors: Koivistoinen
authors: V C
authors: VC
authors: Morris
authors: O A
authors: OA
authors: Levander
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D003386:Brachyura; D005399:Fishes / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D009753:Nutritive Value; D010125:Ostreidae; D033561:Penaeidae; D051381:Rats; D011916:Rats, Inbred F344; D012643:Selenium / Q000097:blood / Q000493:pharmacokinetics*; D012758:Shellfish / Q000032:analysis*
chemical_list: D005979:Glutathione Peroxidase; D012643:Selenium