Comparative study of the effects of 9 antidepressants on several physiological parameters in healthy volunteers.
Effects on physiological parameters were compared among 9 antidepressants (amitriptyline 50 mg, imipramine 50 mg, nortriptyline 50 mg, amoxapine 50 mg, maprotiline 50 mg, mianserin 20 mg, zimelidine 100 mg, nomifensine 50 mg, and Y-8894 50 mg) after a single oral administration in healthy volunteers. Critical fusion frequency of flicker, body sway distance, salivary flow rate, near blurred point, and pulse rate were employed as parameters. The degree of the drug effects on the physiological parameters could be roughly classified into two to four groups according to maximum percent deviation of each parameter.
Ogura
C
C
Department of Neuropsychiatry, School of Medicine, University of the Ryukyus, Okinawa, Japan.
Kishimoto
A
A
Mizukawa
R
R
Matsubayashi
M
M
Omura
F
F
Kunimoto
N
N
D000328:Adult; D000928:Antidepressive Agents / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D005425:Flicker Fusion / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D004856:Postural Balance / Q000187:drug effects; D012472:Salivation / Q000187:drug effects; D012684:Sensory Thresholds
D000928:Antidepressive Agents