Compounds with potential anticancer activity. Benzenesulfonamido-pyrimidine derivatives.
Some derivatives of N-(5-pyrimidinyl)benzenesulfonamide, variously substituted at the benzene and pyrimidine ring, and variously methylated at ring and/or sulfonamidic nitrogens, were re-prepared. The activity of these compounds against lymphocytic leukemia P388 was evaluated and proved to be negligible or completely absent.
Pecorari
P
P
Dipartimento di Scienze Farmaceutiche dell'Università di Modena, Italy.
Vampa
G
G
Rinaldi
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D011743:Pyrimidines; D013449:Sulfonamides