Glutathione peroxidase activity in patients with rheumatoid arthritis and in normal subjects: effects of long-term selenium supplementation.
The effects of dietary supplementation with selenium were studied in 6 patients with severe, active rheumatoid arthritis (RA) and in 6 healthy control subjects. Initial concentrations of Se in red blood cells and in serum, and the activity of the Se-dependent enzyme glutathione peroxidase (GSH-Px) in red blood cells, serum, and granulocytes were significantly lower in RA patients compared with controls. During Se supplementation, however, the differences in Se levels and in GSH-Px activity between the 2 groups disappeared, except that, in RA patients, GSH-Px activity in granulocytes increased but remained significantly lower than in controls.
Tarp
U
U
Rheumatism Research Unit, Orthopaedic Hospital, University of Aarhus, Denmark.
Hansen
J C
JC
Overvad
K
K
Thorling
E B
EB
Tarp
B D
BD
Graudal
H
H
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000201:enzymology*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood* / Q000172:deficiency; D006098:Granulocytes / Q000201:enzymology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012643:Selenium / Q000097:blood / Q000172:deficiency / Q000494:pharmacology*
D005979:Glutathione Peroxidase; D012643:Selenium