Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA.
Following oral administration of a renal carcinogen, potassium bromate (KBrO3), to the rat, a significant increase of 8-hydroxydeoxyguanosine (8-OH-dG) in kidney DNA was observed. In the liver, a non-target tissue, the increase in 8-OH-dG was not significant. The non carcinogenic oxidants, NaCIO and NaCIO2, had no effect on 8-OH-dG formation in kidney DNA. These results suggest that formation of 8-OH-dG in tissue DNA is closely related to KBrO3 carcinogenesis.
Kasai
H
H
Biology Division, National Cancer Center Research Institute, Tokyo, Japan.
Nishimura
S
S
Kurokawa
Y
Y
Hayashi
Y
Y
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D001959:Bromates / Q000008:administration & dosage; D001966:Bromine / Q000008:administration & dosage; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000139:chemically induced*; D051381:Rats
D001959:Bromates; C019536:potassium bromate; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D003849:Deoxyguanosine; D001966:Bromine