A simplified thin-layer chromatography system for the detection of commonly abused basic drugs.
A simple method for the detection of drugs of abuse and their metabolites in urine is described. By extraction of urine (20 mL) with a buffered ToxElut solid phase column all the commonly abused opioid drugs can be detected on a single thin-layer chromatography plate. Location of the spots is achieved by spraying the plate with iodoplatinate following acidification with dilute sulphuric acid. Sensitivity of the order of 1 mg/L is attained for most drugs.
Blakesley
J
J
Department of Analytical Pharmacology, Ealing Hospital, Southall, Middlesex, UK.
Wood
D
D
Howse
C
C
Spencer-Peet
J
J
D002855:Chromatography, Thin Layer / Q000379:methods; D006801:Humans; D013287:Illicit Drugs / Q000652:urine*; D009294:Narcotics / Q000652:urine*
D013287:Illicit Drugs; D009294:Narcotics