Penetration of ciprofloxacin into parotid gland tissue and parotid saliva.
The penetration of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid (ciprofloxacin, Bay o 9867, Ciprobay) into parotid gland tissue and parotid saliva of the rat after intravenous administration (6 mg/kg body weight) was studied. 2 h after bolus injection ciprofloxacin mean levels in parotid gland tissue (0.60 mg/l) nearly reached 2-fold mean blood levels (0.36 mg/l). In parotid saliva the mean concentration of the gyrase inhibitor (0.20 mg/l) was lower than in blood, however, still high enough to be effective against the pathogens which most often cause inflammation of the parotid gland.
Maier
H
H
Hals-Nasen-Ohrenklinik, Justus-Liebig-Universität, Giessen, Fed. Rep. of Germany.
Sziegoleit
A
A
Merck
S
S
D000818:Animals; D002939:Ciprofloxacin / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D010306:Parotid Gland / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000378:metabolism*
D002939:Ciprofloxacin