The influence of some antidepressant drugs on the nuclear volume of rat cingular cortex cells in culture.
The changes in the volume of cell nuclei of the rat cingular cortex were investigated in culture after incubation with some antidepressant drugs. Two-week incubation of the cingular cortex culture with both tricyclic (desipramine, imipramine, amitryptyline) and non-tricyclic (mianserin) antidepressants in concentration of 3 X 10(-6) M resulted in a decrease of the volume of the cell nuclei. Because the size of the nucleus is regarded as a criterion of the cell metabolic activity, our results may point to a diminished activity of metabolic processes of the cells.
Bal
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Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Smiałowska
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M
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D002467:Cell Nucleus / Q000187:drug effects* / Q000648:ultrastructure; D002478:Cells, Cultured; D006179:Gyrus Cinguli / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic