title: New tylosin analogs produced by mutants of Streptomyces fradiae.
abstract: 2'''-Demethoxytylosin (component IIIc), 2'''-demethoxy-4'''-epi-tylosin (component IIId) and 2'''-O-demethyltylosin (component Vb) were produced by blocked mutant strains of Streptomyces fradiae. Fermentation, isolation, structure determination and biosynthetic considerations of these tylosin analogs are described.
authors: Sanraku Inc., Central Research Laboratories, Fujisawa, Japan.
authors: K
authors: K
authors: Kiyoshima
authors: K
authors: K
authors: Takada
authors: M
authors: M
authors: Yamamoto
authors: K
authors: K
authors: Kubo
authors: R
authors: R
authors: Okamoto
authors: Y
authors: Y
authors: Fukagawa
authors: T
authors: T
authors: Ishikura
authors: H
authors: H
authors: Naganawa
authors: T
authors: T
authors: Sawa
authors: T
authors: T
authors: Takeuchi
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D007933:Leucomycins / Q000096:biosynthesis; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009154:Mutation; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*; D013329:Structure-Activity Relationship; D015645:Tylosin
chemical_list: D007933:Leucomycins; D015645:Tylosin