Constriction of cat coronary arteries by synthetic thromboxane A2 and its antagonism.
Synthetic thromboxane A2 (TxA2S) induced rapid, concentration-dependent constriction of isolated perfused cat coronary arteries. Its potency was approximately 30 times that of the prostaglandin endoperoxide, PGH2. Pinane thromboxane A2 (PTA2), BM-13.505 and SQ-29,548, compounds previously shown to antagonize the effects of stable prostaglandin endoperoxide analogs, inhibited the constriction induced by TxA2S in a concentration-dependent fashion. These experiments provide further evidence that the oxetane structure proposed for TxA2 is correct and show that compounds that inhibit the effects of prostaglandin endoperoxides also antagonize the effects of TxA2.
Smith
J B
JB
Department of Pharmacology, Temple University Medical School, Philadelphia, PA 19140.
Yanagisawa
A
A
Zipkin
R
R
Lefer
A M
AM
D000818:Animals; D000081008:Bicyclic Monoterpenes; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002415:Cats; D003331:Coronary Vessels / Q000502:physiology*; D005231:Fatty Acids, Unsaturated; D006834:Hydrazines / Q000494:pharmacology; D010648:Phenylacetates / Q000494:pharmacology; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology; D044262:Prostaglandin H2; D011463:Prostaglandins H / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology; D013928:Thromboxane A2 / Q000031:analogs & derivatives / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*
D000081008:Bicyclic Monoterpenes; D019086:Bridged Bicyclo Compounds, Heterocyclic; D005231:Fatty Acids, Unsaturated; D006834:Hydrazines; D010648:Phenylacetates; D011450:Prostaglandin Endoperoxides, Synthetic; D011463:Prostaglandins H; D013449:Sulfonamides; D044262:Prostaglandin H2; D013928:Thromboxane A2; C020465:pinane-thromboxane A2; C045749:SQ 29548; C051762:daltroban