title: Meconium ileus: a fifteen-year experience with forty-two neonates.
abstract: From 1969 to 1984, 42 neonates were managed for meconium ileus caused by cystic fibrosis. Simple, uncomplicated meconium ileus occurred in 24 infants (57%) and complicated meconium ileus occurred in 18 (43%). Meglumine diatrizoate (Gastrografin) enema completely relieved the obstruction in 13 patients with simple meconium ileus (54%) and caused colonic and rectal perforations in three (13%). Six operative procedures were used in 29 patients: double enterostomy (seven), resection with primary anastomosis (seven), Bishop-Koop enterostomy (seven), intraluminal lavage (four), colostomy (three), and Mikulicz enterostomy (one). Postoperative complications included malabsorptive diarrhea (nine), pneumonia (three), intestinal obstruction (two), total parenteral nutrition-catheter sepsis (two), and anastomotic leak (one). Infants managed nonoperatively by Gastrografin enema had a significantly shorter hospitalization (average, 15 days) than those undergoing operation for simple meconium ileus (54 days) and complicated meconium ileus (111 days). Postoperative survival rate was 100% with a late survival rate of 86%.
authors: Department of Surgery, Ohio State University College of Medicine, Columbus.
authors: D A
authors: DA
authors: Caniano
authors: B L
authors: BL
authors: Beaver
mesh_terms: D003550:Cystic Fibrosis / Q000150:complications* / Q000401:mortality; D003974:Diatrizoate Meglumine / Q000627:therapeutic use*; D004766:Enterostomy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007415:Intestinal Obstruction / Q000209:etiology* / Q000601:surgery / Q000628:therapy; D008297:Male; D008470:Meconium
chemical_list: D003974:Diatrizoate Meglumine