A comparison of postmortem heart blood and femoral blood ethyl alcohol concentrations.
Recent research has indicated that substantial differences may exist between the concentration of organic bases in heart blood specimens and that in peripheral blood specimens. This study was designed to determine the distribution characteristics of ethyl alcohol in postmortem blood. The heart blood/femoral blood ethyl alcohol ratio was determined for 100 cases. In the majority of cases exhibiting alcohol concentration differences greater than 0.02 mg/dL, the specimens were suspect because of their physical appearance, trauma to the decedent in the area of specimen collection, gross differences in hematocrits, or large volume differences in the two specimens. An additional set of experiments was conducted to illustrate that the volume of blood and the amount of sodium fluoride preservative placed in the collection tube can have a substantial effect upon the subsequently measured ethyl alcohol concentration. These factors can adversely affect the observed heart blood/femoral blood alcohol ratio and must be considered when evaluating the distribution characteristics of ethyl alcohol in postmortem specimens.
Prouty
R W
RW
Office of the Chief Medical Examiner, State of Oklahoma, Oklahoma City 73117.
Anderson
W H
WH
D001800:Blood Specimen Collection; D004058:Diffusion; D000431:Ethanol / Q000097:blood* / Q000493:pharmacokinetics; D005268:Femoral Vein; D005753:Gastric Mucosa / Q000378:metabolism; D006321:Heart; D006801:Humans; D011180:Postmortem Changes; D014116:Toxicology
D000431:Ethanol