In vivo determination of 31P spin relaxation times (T1, T2, T1 rho) in rat leg muscle. Use of an off-axis solenoid coil.
A probe using a solenoid coil tilted 45 degrees off-axis has been used to study the 31P NMR relaxation characteristics of the resonances arising from phosphorus metabolites in rats in vivo. T1, T1 rho and T2 values have been determined for phosphocreatine and ATP in leg muscle. The ratio of 31P T1(1700ms) to T2(12ms) for ATP was in excess of 200:1 compared with a ratio of 5:1 for 1H T1:T2. Of major significance was the observation that T2 values for phosphocreatine (230ms) were markedly longer than T2 values for ATP (12ms). Thus by use of appropriate delay times in spin echo sequences ATP signals can be nulled, and discrete 31P imaging of phosphocreatine in muscle may be possible provided the overall signal-to-noise is satisfactory.
Brooks
W M
WM
School of Science, Griffith University, Nathan, Australia.
Field
J
J
Irving
M G
MG
Doddrell
D M
DM
D000818:Animals; D006614:Hindlimb; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D009132:Muscles / Q000033:anatomy & histology*; D010758:Phosphorus; D051381:Rats
D010758:Phosphorus