Relationship between elevated fibrinopeptide A levels and alpha-2-antiplasmin.
In order to investigate whether alpha 2-antiplasmin (alpha 2-AP) levels may be related to thrombin activity, we measured alpha 2-AP and fibrinopeptide A (FPA) in 51 patients with clinical conditions frequently associated with increased thrombin activity. The diagnoses were: atherosclerotic disease, chronic inflammatory disease and hematological neoplastic disease. A significant negative correlation was found between alpha 2-AP and FPA (p less than 0.01). When patients were divided into three subgroups on the basis of their FPA levels, a significant reduction in alpha 2-AP was found in patients with the highest FPA concentration (greater than 9 ng/ml). Accordingly, a significant negative relationship between alpha 2-AP and FPA was found only in this subgroup (p less than 0.01). Our data suggest that the partial consumption of alpha 2-AP in patients with elevated FPA levels may reflect a subclinical fibrinolysis activation secondary to increased thrombin activity.
Marongiu
F
F
Istituto di Medicina Interna, Università di Cagliari, Italia.
Mulas
G
G
Mamusa
A M
AM
Mameli
G
G
Marassi
P P
PP
Tronci
M B
MB
Cambuli
A B
AB
Acca
M R
MR
Balestrieri
A A
AA
D000293:Adolescent; D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood* / Q000378:metabolism; D003095:Collagen Diseases / Q000097:blood* / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D005344:Fibrinopeptide A / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000979:alpha-2-Antiplasmin / Q000378:metabolism*
D000979:alpha-2-Antiplasmin; D005344:Fibrinopeptide A; D005340:Fibrinogen