[Suppressive effect of lentinan on pulmonary metastases in murine tumors].
Lentinan has been shown to have a suppressive effect on the natural pulmonary metastasis of Lewis lung carcinoma, though its effect seems to depend on the timing of the administration. Administration of lentinan after the amputation of tumor was found to be more effective than before administration. Additionally, lentinan also has shown a marked suppressive effect on the pulmonary metastasis of MC-CS-1 fibrosarcoma, a high sensitive tumor for lentinan in any administration examined. These date suggest the usefulness of lentinan in suppressing tumor metastasis.
Shiio
T
T
Life Sci. Lab. Ajinomoto Co., Inc.
Kitamura
K
K
Ohishi
K
K
Yugari
Y
Y
D000818:Animals; D005354:Fibrosarcoma / Q000188:drug therapy / Q000473:pathology; D007912:Lentinan / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D011134:Polysaccharides / Q000627:therapeutic use*; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000473:pathology
D011134:Polysaccharides; D007912:Lentinan