A material (PUPA) presenting both the properties of polyurethanes and the capacity of adsorbing a high quantity of heparin.
Polyurethanes are widely used for biomedical applications, but there is still a constant search for improved blood-compatible materials. We studied a material (PUPA) obtained by the interconnection between a poly(amido-amine), N2LL, capable of forming stable complexes with heparin and a commercial polyurethane, Pellethane 2363-80AE, using hexamethylenediisocyanate as the crosslinking agent. The amount of absorbed heparin (evaluated by biological tests) was generally much higher than that found on the poly(amido-amine) surface-grafted polyurethane.
Barbucci
R
R
C.R.I.S.M.A. Centro Didattico Università di Siena, Italy.
Benvenuti
M
M
Dal Maso
G
G
Ferruti
P
P
Tempesti
F
F
Lemm
W G
WG
D000327:Adsorption; D001672:Biocompatible Materials; D006493:Heparin; D008422:Materials Testing; D011140:Polyurethanes
D001672:Biocompatible Materials; D011140:Polyurethanes; D006493:Heparin