Protective effect of a PAF-acether antagonist, BN 52021, in trichothecene toxicosis.
Trichothecenes are mycotoxins which produce lethal toxicosis in humans and animals, yet no adequate therapeutic regimen has been developed. This study provides evidence that the selective platelet activating factor (PAF) antagonist, BN 52021 (5-15 mg/kg i.v.) can prolong the survival of conscious rats exposed to a highly lethal T-2 toxicosis. These data also suggest that PAF is an important mediator of this unique toxicosis.
Feuerstein
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G
Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799.
Leader
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P
Siren
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Braquet
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D000818:Animals; D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000633:toxicity*; D013605:T-2 Toxin / Q000633:toxicity*
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010936:Plant Extracts; D010972:Platelet Activating Factor; D012717:Sesquiterpenes; C045856:ginkgolide B; D013605:T-2 Toxin