Comparative bioavailability study of two preparations of alpha-methyldopa after single, oral doses.
Bioavailability of alpha-methyldopa from a film coated tablet Dopegyt (EGIS Pharmaceutical Works, Budapest, Hungary) and from Aldometil (MSD, Sharp and Dohme GmbH, Munich, FRG) containing 250 mg of effective substance, was investigated in a crossover study in six patients with mild hypertension having normal renal and liver functions. Alpha-methyldopa was determined in plasma by fluorometry. There was no difference in the pharmacokinetic parameters calculated (Cl, Vd, AUC, t1/2) indicating that the two preparations are bioequivalent.
Róna
K
K
Postgraduate Medical School, 1st Department of Internal Medicine, Budapest, Hungary.
Gachályi
B
B
Vereczkey
L
L
Nádas
B
B
Káldor
A
A
D000328:Adult; D001682:Biological Availability; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008750:Methyldopa / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008875:Middle Aged
D008750:Methyldopa