Chemistry and pharmacology of a tertiary alkaloid from Strychnos trinervis root bark.
Bisnordihydrotoxiferine has been isolated as the major alkaloid from the root bark of Strychnos trinervis. This compound shows a wide antimicrobial spectrum against gram-positive, gram-negative and acid-fast microorganisms, filamentous and yeast-like fungi and also phytopathogenic microorganisms. Preliminary studies also reveal some cytotoxic activity in KB cells which was confirmed by tests against sarcoma 180 tumors.
Melo
M F
MF
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa, Brazil.
Santos
C A
CA
Chiappeta
A A
AA
de Mello
J F
JF
Mukherjee
R
R
D000470:Alkaloids / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002478:Cells, Cultured; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000032:analysis*; D014117:Toxiferine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; C053959:bisnordihydrotoxiferine; D014117:Toxiferine