title: Oral ethanol reinforcement in the rat: effect of the partial inverse benzodiazepine agonist RO15-4513.
abstract: The partial inverse benzodiazepine agonist RO15-4513 has been found to reverse the sedating and anti-conflict effects of acute ethanol administration. In non-food or fluid-deprived rats, orally self-administering 10% ethanol in an operant situation, RO15-4513 resulted in a dose-dependent suppression on ethanol intake. Doses of 0.3, 1.0 and 3.0 mg/kg suppressed responding from approximately 25% to 60% respectively. A dose of 0.1 mg/kg had no significant effect upon responding. These findings were discussed in terms of the potential independence of brain mechanisms related to ethanol reinforcement and sedation.
authors: Alcoholism and Drug Abuse Institute, University of Washington, Seattle 98105.
authors: H H
authors: HH
authors: Samson
authors: G A
authors: GA
authors: Tolliver
authors: A O
authors: AO
authors: Pfeffer
authors: K G
authors: KG
authors: Sadeghi
authors: F G
authors: FG
authors: Mills
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001386:Azides / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D012054:Reinforcement, Psychology; D012646:Self Administration
chemical_list: D001386:Azides; D001569:Benzodiazepines; D000431:Ethanol; C042957:Ro 15-4513