title: Peroxidation of brain lipids following cyanide intoxication in mice.
abstract: Lipid peroxidation of brain lipids as determined by the conjugated diene method was observed in mice following administration of sublethal doses of potassium cyanide (KCN). Conjugated diene production was dose- and time-dependent; 10 mg/kg KCN produced detectable levels of conjugated dienes at 30 min post cyanide, whereas, 15 mg/kg produced marked levels of conjugated dienes over a 10-60-min period after KCN. Pretreatment of mice with either diltiazem (600 micrograms/kg, i.v.) or allopurinol (25 mg/kg, i.v.) blocked the generation of conjugated dienes. These results suggest lipid peroxidation of neuronal membranes play a role in cyanide intoxication and this action is related to altered regulation of neuronal calcium homeostasis and activation of xanthine oxidase.
authors: Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907.
authors: J D
authors: JD
authors: Johnson
authors: W G
authors: WG
authors: Conroy
authors: K D
authors: KD
authors: Burris
authors: G E
authors: GE
authors: Isom
mesh_terms: D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D003486:Cyanides / Q000506:poisoning*; D004110:Diltiazem / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D051379:Mice; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
chemical_list: D003486:Cyanides; D008054:Lipid Peroxides; D000493:Allopurinol; D014969:Xanthine Oxidase; D004110:Diltiazem; D002118:Calcium