Naloxone and lithium interaction on the levels of homovanillic acid in the rat brain.
The effects of long term (10 days) treatment of lithium and naloxone on HVA levels of striatum, hypothalamus and frontal cortex in rats were investigated. Lithium (400 mg/l in drinking water) itself had no effect on HVA levels of any region. Naloxone (2 mg/kg) treatment caused significant increases in the levels of HVA in hypothalamus and striatum and lithium cotreatment prevented the effect of naloxone. Neither of those were observed in the frontal cortical region.
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Department of Pharmacology, Istanbul Medical Faculty, University of Istanbul, Capa, Turkey.
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Eroğlu
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D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D006719:Homovanillic Acid / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009270:Naloxone; D008094:Lithium; D006719:Homovanillic Acid