title: Pharmacokinetically guided dose escalation in phase I clinical trials. Commentary and proposed guidelines. EORTC Pharmacokinetics and Metabolism Group.
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000378:metabolism; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D006801:Humans; D007700:Kinetics; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents