[Modelling psychosis in cats by creating a generator of pathologically enhanced excitation in one of the septal nuclei].
The experiments on adult freely behaving cats have shown that the injection of penicillin into the internal part (TI) of bed nucleus of stria terminalis (BST) caused the formation of the generator of pathologically enhanced excitation (GPEE). This part of BST became hyperactive and played the role of a pathologic determinant which caused the formation of a complex pathologic system and behavioural disorders with catatonia, stereotypy, food rejection, eating of uneatable things, hypoalgesia, zoosocial behavioural changes, depression of different emotions, etc. The development of these disorders was progressing and was accompanied by corresponding electrophysiological activity in TI and other brain structures studied. Coagulation of GPEE zone at the early stages of the process prevented the development of the above disorders.
Kryzhanovskiĭ
G N
GN
Lobasiuk
B A
BA
Mokhovikov
A N
AN
Bartsevich
L B
LB
Mosketi
K V
KV
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002415:Cats / Q000502:physiology*; D004195:Disease Models, Animal; D004564:Electrocoagulation; D004594:Electrophysiology; D009433:Neural Inhibition / Q000187:drug effects; D010406:Penicillins / Q000633:toxicity; D011605:Psychoses, Substance-Induced / Q000209:etiology* / Q000503:physiopathology; D012686:Septal Nuclei / Q000187:drug effects / Q000503:physiopathology*; D013997:Time Factors
D010406:Penicillins
Modelirovanie psikhoza u koshek putem sozdaniia generatora patologicheski usilennogo vozbuzhdeniia v odnom iz iader septal'noĭ oblasti.