Selective pancreatic toxicity of palmitoylpentachlorophenol.
Palmitoylpentachlorophenol (PPCP), which is a lipid conjugate of a xenobiotic compound, has been found in human fat. To study the toxicity associated with PPCP, rats were given 100 mg/kg PPCP and sacrificed at 4, 8 and 12 days. The target organ identified was the exocrine pancreas; no other major organs examined showed any gross or histopathological abnormality. At 4 and 8 days after treatment, focal, spotty vacuolation, and loss of pancreatic acini was observed. Acute inflammatory infiltrate was also observed in parenchyma at all time points and the loss of acinar tissue was resolved through fibrous tissue formation by 12 days. The present study indicates that PPCP has a specific target organ toxicity.
Ansari
G A
GA
Department of Pathology, University of Texas Medical Branch, Galveston 77550.
Kaphalia
B S
BS
Boor
P J
PJ
D000818:Animals; D002733:Chlorophenols / Q000633:toxicity*; D005227:Fatty Acids / Q000378:metabolism; D008297:Male; D010168:Palmitates / Q000633:toxicity*; D010169:Palmitic Acids / Q000633:toxicity*; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology; D010416:Pentachlorophenol / Q000031:analogs & derivatives / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D014617:Vacuoles / Q000187:drug effects
D002733:Chlorophenols; D005227:Fatty Acids; D010168:Palmitates; D010169:Palmitic Acids; C045884:pentachlorophenyl palmitate; D010416:Pentachlorophenol