Effect of levamisole on binding of immune complex to mouse peritoneal macrophages.
Levamisole at the concentrations of 240 and 500 micrograms/ml increased DNA-anti-DNA immune complex (IC) binding to thioglycollate-stimulated mouse (CBA) peritoneal macrophages. Reduced IC binding by macrophages of (NZB/NZW)F1 a mouse model for systemic lupus erythematosus occurs as a consequence of disease and was partially corrected after inclusion of levamisole into the reaction mixture in vitro. However, in vivo administration of 2.5 mg/kg of levamisole, the therapeutic dose, did not alter IC binding to CBA macrophages.
Rezai
H R
HR
Department of Medical Pathology, University of California, Davis.
Ardehali
S
S
Fabbri
B
B
Teplitz
R L
RL
D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D007978:Levamisole / Q000494:pharmacology*; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA; D008814:Mice, Inbred NZB; D010587:Phagocytosis / Q000187:drug effects
D000936:Antigen-Antibody Complex; D007978:Levamisole