Intravenous streptokinase treatment and serum C-reactive protein in patients with acute myocardial infarction.
Serum concentrations of C-reactive protein were studied in 23 patients with acute myocardial infarction. In 14 patients who did not receive thrombolytic treatment there was a linear relation between infarct size (determined by serial creatine kinase-MB determinations and thallium-201 isotope emission tomography) and the C-reactive protein response. The correlation coefficient between the concentration-time integrals of creatine kinase-MB and C-reactive protein was 0.96. The correlation coefficient between the creatine kinase-MB concentration-time integral and the peak serum value of C-reactive protein was 0.93. In the nine patients who received intravenous streptokinase treatment there was also a positive correlation between the concentration-time integrals of creatine kinase-MB and C-reactive protein. The relation, however, depended on the success of the treatment. In patients with successful reperfusion the C-reactive protein response was only approximately 20% of that in patients in whom reperfusion failed or who received no thrombolytic treatment and who were matched by infarct size. When thrombolysis was successful the correlation coefficient between the concentration-time integrals of creatine kinase-MB and C-reactive protein was 0.86. Daily measurement of serum C-reactive protein is useful in evaluating infarct size in patients with acute myocardial infarction who do not receive thrombolytic treatment. In patients treated with streptokinase C-reactive protein concentrations may be used to assess the success of thrombolysis.
Pietilä
K
K
Department of Medicine, Tampere University Central Hospital, Finland.
Harmoinen
A
A
Pöyhönen
L
L
Koskinen
M
M
Heikkila
J
J
Ruosteenoja
R
R
D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D003402:Creatine Kinase / Q000097:blood; D006801:Humans; D007527:Isoenzymes; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000201:enzymology; D011877:Radionuclide Imaging; D013300:Streptokinase / Q000627:therapeutic use*
D007527:Isoenzymes; D002097:C-Reactive Protein; D003402:Creatine Kinase; D013300:Streptokinase