Effect of sub-inhibitory concentrations of antibiotics on adhesion of Campylobacter jejuni in vitro.
The effects of sub-inhibitory concentrations (MIC 50 and MIC 25) of clindamycin, erythromycin and chloramphenicol on the adherence of Campylobacter jejuni to INT 407 cells were studied. The results indicated that the adhesion was inhibited at various extents, mostly by MIC 50, and that the inhibition increased with time. The interpretation of our data is that the antibiotics can interfere with the adhesin(s) synthesis.
Cinco
M
M
Istituto di Microbiologia, Università degli Studi di Trieste, Italy.
Banfi
E
E
Crevatin
D
D
Ruaro
E
E
D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D002168:Campylobacter fetus / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D002478:Cells, Cultured; D002701:Chloramphenicol / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D004847:Epithelial Cells; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D002981:Clindamycin; D004917:Erythromycin; D002701:Chloramphenicol