Nonneoplastic lesions of the ovary in Fischer 344 rats and B6C3F1 mice.
The National Toxicology Program's pathology database on 2-year carcinogenicity studies was reviewed for nonneoplastic ovarian disease. Ovaries from 39,941 female Fischer rats and 41,444 female B6C3F1 mice were examined. A variety of inflammatory, degenerative, vascular, and proliferative lesions were documented and are described. The most common ovarian lesions in rats were cysts (6%). The most frequent ovarian lesions in mice were cysts (15%), acute inflammation (4%), degeneration (4%), vascular disease (2.5%), and atrophy (2%). There was no difference in incidence of ovarian disease between controls and treated animals. The frequency of ovarian disease in mice exceeded the frequency in rats in every category.
Montgomery
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CA
National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Alison
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RH
D000818:Animals; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D010048:Ovarian Cysts / Q000473:pathology; D010049:Ovarian Diseases / Q000473:pathology*; D010053:Ovary / Q000473:pathology*; D010859:Pigmentation Disorders / Q000473:pathology; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D013045:Species Specificity