Establishment of cut off values for vanillylmandelic acid and homovanillic acid in 24-hr urine accumulation during mass screening for neuroblastoma.
The establishment of cut off values in vanillylmandelic acid (VMA) and homovanillic acid (HVA) in 24-hr urine specimens for the purpose of separating true positive cases from normal infants has been discussed. The specimens were collected at the time when thorough examinations under a mass screening programme for neuroblastoma were taking place, and data from 17 infants with neuroblastoma (patients) and 50 healthy infants (controls) have been employed. The function square root VMA2 + HVA2 = 34 (micrograms/mg of creatinine) separated the two groups with no overlapping cases. This function represents the distance from the origin of the VMA-HVA co-ordinates, and is thought to be one of the most reasonable discriminant methods when considering the distribution pattern of the data for normal cases and patients.
Nishi
M
M
Department of Public Health, Sapporo Medical College, Japan.
Miyake
H
H
Takeda
T
T
Takasugi
N
N
Sato
Y
Y
Hanai
J
J
D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000652:urine; D005260:Female; D006719:Homovanillic Acid / Q000652:urine*; D006801:Humans; D007223:Infant; D007564:Japan; D008297:Male; D008403:Mass Screening; D009447:Neuroblastoma / Q000453:epidemiology / Q000652:urine; D014642:Vanilmandelic Acid / Q000652:urine*
D014642:Vanilmandelic Acid; D003404:Creatinine; D006719:Homovanillic Acid