[Drug liberation from floating capsules in the rotating-flask solubility tester].
In this communication, a report is presented on the drug liberation from so-called floating capsules (with 10 and 15 mg diazepam) and from several other comparable oral and rectal drug dosage forms in the rotating flask model (Resotest-System). None of the commercially available preparations exhibits any availability problem. The rotating flask was suitable and appears as superior over the official dissolution apparatuses with regard to the testing of drug dosage forms that float on the surface of the dissolution medium.
Koch
H P
HP
Institut für Pharmazeutische Chemie, Universität Wien, Osterreich.
Mertz
M
M
Zinterhof
G
G
D002214:Capsules / Q000032:analysis*; D002626:Chemistry, Pharmaceutical; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012995:Solubility; D012997:Solvents; D013678:Technology, Pharmaceutical
D002214:Capsules; D004364:Pharmaceutical Preparations; D012997:Solvents
Wirkstoffiberation aus Schwimmkapseln im Drehkolben-Dissolutionstester.