[Effect of a new peptide morphogen on androgen metabolism in the gonads during sexual maturation in the rat].
After chronic administration of a new neuropeptide (hydra growth activator--HGA) to male and female Wistar rats from the 29th to 43rd day of life at a dose of 30 micrograms X kg-1 of body mass a study was made of [3H] testosterone, [3H] 5 alpha-dehydrotestosterone [( 3H] DHT) and [3H] 5 alpha-androstane-3 beta, 17 beta-diol metabolism in gonadal homogenates of the animals. In testis homogenates HGA administration was shown to influence the production of [3H] 3 beta-diol from [3H] DHT only. In female rats HGA administration made an effect on the majority of enzymes of androgen metabolism in the ovaries of animals with the closed and open vagina. Basing on changes in enzymatic activity of androgen metabolism in the gonads of rats in chronic HGA administration in the period of male pubescence a conclusion was made that it acted as a pubescence accelerating factor.
Vinogradov
V A
VA
Degtiar'
V G
VG
Krivosheev
O G
OG
Miloserdov
Iu V
IuV
Rubina
A Iu
AIu
D000728:Androgens / Q000378:metabolism*; D000818:Animals; D005260:Female; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains; D012741:Sexual Maturation / Q000187:drug effects*; D013268:Stimulation, Chemical; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D000728:Androgens; D009479:Neuropeptides; C032522:head activator peptide; D011761:Pyrrolidonecarboxylic Acid
Vliianie novogo peptidnogo morfogena na metabolizm androgenov v gonadakh pri polovom sozrevanii krys.