[Substances inhibiting amine oxidases. III. Synthesis and amine oxidase inhibition of imidazoquinoline derivatives].
The activity of copper and FAD dependent amine oxidases was tested with some derivatives of 3H-imidazo[4,5-h]quinoline and its isomers 3H-imidazo[4,5-f]quinoline, the chemistry of which is described in the literature (1), and Ki calculated. The methyl derivative of 3H-imidazo[4,5-f]quinoline was found to activate the copper bovine serum enzyme, but inhibits the FAD mitochondrial enzyme.
Chimenti
F
F
Istituto di Chimica Farmaceutica e Tossicologica, Università, Sapienza, Roma.
Bolasco
A
A
Vomero
S
S
Casanova
M C
MC
Befani
O
O
Sabatini
S
S
Turini
P
P
Mondovì
B
B
Gagliardi
L
L
D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D008862:Microsomes, Liver / Q000201:enzymology; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D007093:Imidazoles; D008996:Monoamine Oxidase Inhibitors; D011804:Quinolines
Ricerche su sostanze inibitrici delle aminossidasi. Nota III. Sintesi ed attività inibitrice sulle aminossidasi di derivati delle imidazochinoline.