13-week subchronic toxicity study with morpholine oleic acid salt administered to B6C3F1 mice.
The effect of subchronic administration of morpholine oleic acid salt (MOAS) was studied in B6C3F1 mice. The dose levels of MOAS used were 0%, 0.15%, 0.3%, 0.6%, 1.25%, and 2.5% in drinking water. Reduced weight gains were noted in both sexes in the 2.5% group as compared to controls, but reductions were not significant. Water consumption values showed a dose-related tendency for a decrease in both females and males. Urine analysis showed significant elevation of specific gravity in the males in the 0.6%, 1.25%, and 2.5% groups and the females in the 1.25% and 2.5% groups. Significant elevation of plasma urea nitrogen was observed in males of the 1.25% and 2.5% groups and in females of the 0.6%, 1.25%, and 2.5% groups. The relative weight of the kidneys showed a dose-dependent increase that was statistically significant for the 1.25% and 2.5% MOAS groups in both sexes. Except for cloudy swelling of the proximal tubules of the kidneys in mice on the 2.5% regimen, no treatment-related histopathological alterations were observed in organs of either sex.
Shibata
M
M
First Department of Pathology, Nagoya City University Medical School, Japan.
Kurata
Y
Y
Tamano
S
S
Ogiso
T
T
Fukushima
S
S
Ito
N
N
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney / Q000033:anatomy & histology; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D051379:Mice; D009025:Morpholines / Q000633:toxicity*; D019301:Oleic Acid; D009829:Oleic Acids / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects
D009025:Morpholines; D009829:Oleic Acids; D019301:Oleic Acid