A double-peak phenomenon in the pharmacokinetics of veralipride after oral administration: a double-site model for drug absorption.
Equal doses of veralipride have been given to 12 healthy volunteers by three different administrations--intravenous infusion, oral solution, and oral capsules--in a randomized cross-over design. After the intake of the solution, but not after infusion or capsules, two maximum plasma concentrations have been observed and interpreted, according to a double-site model for drug absorption.
Plusquellec
Y
Y
U.E.R. de Mathématiques, Université Paul Sabatier, Toulouse, France.
Campistron
G
G
Staveris
S
S
Barre
J
J
Jung
L
L
Tillement
J P
JP
Houin
G
G
D000284:Administration, Oral; D006801:Humans; D007262:Infusions, Intravenous; D007408:Intestinal Absorption; D008954:Models, Biological; D013469:Sulpiride / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000652:urine
D013469:Sulpiride; C027429:veralipride