title: Measurement of lactate accumulation by in vivo proton NMR spectroscopy during global cerebral ischemia in rats.
abstract: In vivo 1H NMR spectral editing techniques were used to monitor cerebral lactate production during remotely controlled temporary forebrain ischemia in rats. The lactate/N-acetylaspartate (NAA) ratio correlated with survival after ischemia and subsequent reperfusion. The lactate/NAA ratio that predicted death after ischemia in rats was estimated to be approximately 1.3.
authors: Department of Pharmaceutical Chemistry, University of California School of Medicine, San Francisco 94143.
authors: T L
authors: TL
authors: Richards
authors: M A
authors: MA
authors: Keniry
authors: P R
authors: PR
authors: Weinstein
authors: B M
authors: BM
authors: Pereira
authors: B T
authors: BT
authors: Andrews
authors: E J
authors: EJ
authors: Murphy
authors: T L
authors: TL
authors: James
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D007773:Lactates / Q000096:biosynthesis*; D009682:Magnetic Resonance Spectroscopy; D051381:Rats
chemical_list: D007773:Lactates