title: Does REM sleep deprivation induce subsensitivity of presynaptic dopamine or postsynaptic acetylcholine receptors in the rat brain?
abstract: Yawning behavior was used to evaluate the sensitivity of presynaptic dopamine receptors and postsynaptic acetylcholine receptors of normal and REM sleep-deprived (REMSD) rats. The results show a lowering of the dose-response curve obtained with apomorphine and pilocarpine, as well as a shift to the right in the curve obtained with physostigmine. These results suggest that REMSD induces subsensitization of presynaptic dopamine receptors and/or postsynaptic acetylcholine receptors with different characteristics related to the mechanism of action of the cholinomimetic agent employed.
authors: Department of Psychobiology, Escola Paulista de Medicina, São Paulo, Brazil.
authors: S
authors: S
authors: Tufik
authors: L R
authors: LR
authors: Troncone
authors: S
authors: S
authors: Braz
authors: A R
authors: AR
authors: Silva-Filho
authors: B G
authors: BG
authors: Neumann
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects*; D008297:Male; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011950:Receptors, Cholinergic / Q000187:drug effects*; D011954:Receptors, Dopamine / Q000187:drug effects*; D012892:Sleep Deprivation / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology*; D015000:Yawning / Q000187:drug effects
chemical_list: D011950:Receptors, Cholinergic; D011954:Receptors, Dopamine; D010862:Pilocarpine; D001058:Apomorphine