title: Nuclear DNA changes during pathogenesis of squamous carcinoma of the cervix in 3,4-benzopyrene-treated mice.
abstract: The pathogenesis of squamous carcinoma of the uterine cervix was studied by means of morphologic and cytochemical techniques in mice treated with 3,4-benzopyrene. The results indicate that carcinogen-induced transformation of normal cervical epithelium into squamous carcinoma occurs through a sequence of cellular alterations, demonstrated by progressively increasing cellular atypia and a progressively increasing and scattered DNA content.
authors: Department of Oncology, Karolinska Institute and Hospital, Stockholm, Sweden.
authors: I
authors: I
authors: Näslund
authors: C A
authors: CA
authors: Rubio
authors: G U
authors: GU
authors: Auer
mesh_terms: D000818:Animals; D001564:Benzo(a)pyrene; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology*; D002467:Cell Nucleus / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm; D001564:Benzo(a)pyrene