Chromosome aberrations, micronuclei and sister-chromatid exchanges in blood lymphocytes after occupational exposure to low levels of styrene.
Chromosome aberrations, micronuclei and sister-chromatid exchanges were analysed in blood lymphocytes of 21 reinforced plastic workers, exposed to styrene from 1 to 25 years, and 21 control persons. Occupational hygienic measurements showed personal exposure to styrene to range from 34 to 263 mg/m3 air, the average was 98 mg/m3. Urinary mandelic acid levels of the workers varied from below detection limit to 7 mM/1 l urine. No increase was detected in the frequency of any of the cytogenetic endpoints studied. No correlations between the number of aberrations, micronuclei or SCEs on one hand and the extent or duration of exposure to styrene on the other could be detected.
Mäki-Paakkanen
J
J
Department of Industrial Hygiene and Toxicology, Institute of Occupational Health, Helsinki, Finland.
D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations / Q000187:drug effects; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D009153:Mutagens; D012854:Sister Chromatid Exchange / Q000187:drug effects; D012907:Smoking / Q000009:adverse effects; D020058:Styrene; D013343:Styrenes / Q000009:adverse effects*
D000395:Air Pollutants, Occupational; D009153:Mutagens; D013343:Styrenes; D020058:Styrene