Decreased adreno-cortical suppression utilizing the Nebuhaler for inhalation of steroid aerosols.
The influence on the adrenocortical function of high-dose topical glucocorticoids inhaled via conventional devices and via a Nebuhaler, was studied in ten children with asthma. In patients treated with dosages of beclomethasone dipropionate or budesonide, in excess of 2100 micrograms/1.73 m2 body surface, the 24-h urinary excretion of free cortisol increased when the inhaler device was changed from a conventional one to a Nebuhaler. This suggests a decreased systemic influence of the inhaled glucocorticoids when these were administered via a Nebuhaler.
Prahl
P
P
Paediatric Department G, University Hospital (Rigshospitalet), Copenhagen, Denmark.
Jensen
T
T
D000287:Administration, Topical; D000293:Adolescent; D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001507:Beclomethasone / Q000009:adverse effects; D019819:Budesonide; D002648:Child; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D008297:Male; D009330:Nebulizers and Vaporizers; D011282:Pregnenediones / Q000009:adverse effects
D000893:Anti-Inflammatory Agents; D011282:Pregnenediones; D019819:Budesonide; D001507:Beclomethasone; D006854:Hydrocortisone