title: 1,2-Bis(sulfonyl)hydrazines. 3. Effects of structural modification on antineoplastic activity.
abstract: A series of 1,2-bis(sulfonyl)hydrazines was synthesized and evaluated for antineoplastic activity against the L1210 leukemia and the B16 melanoma. The most active agent to emerge from this study, 1,2-bis(methylsulfonyl)-1-methylhydrazine, produced a maximum % T/C for mice bearing the L1210 leukemia or the B16 melanoma of 340% and 278%, respectively. Two N-chloroethyl analogues, conceived as bifunctional alkylating agents, were also synthesized and evaluated for antineoplastic activity against the L1210 leukemia and the B16 melanoma. Although such a modification resulted in retention of antineoplastic activity against both tumor cell lines, it did not result in enhanced antineoplastic activity.
authors: Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510.
authors: K
authors: K
authors: Shyam
authors: R T
authors: RT
authors: Hrubiec
authors: R
authors: R
authors: Furubayashi
authors: L A
authors: LA
authors: Cosby
authors: A C
authors: AC
authors: Sartorelli
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000188:drug therapy; D008546:Melanoma, Experimental / Q000188:drug therapy; D008763:Methylhydrazines / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D008763:Methylhydrazines