Deep venous thrombosis and pulmonary embolism. Risk of subsequent malignant neoplasms.
We conducted a noncurrent prospective study of all Olmsted County, Minnesota, residents who had had a lower-extremity venogram, pulmonary angiogram, or lung scan performed because of suspicion of deep venous thrombosis or pulmonary emboli. One hundred thirteen cancer-free patients were followed for 386 person-years from the date of procedure. Nine subsequent cancers were observed compared with 4.5 expected (relative risk, 2.0; 95% confidence interval, 0.9 to 3.8), using total cancer incidence rates for the Rochester, Minn, population. Five hundred seventeen cancer-free controls were followed for 2072 person-years. Twenty subsequent cancers were observed compared with 11.6 expected, yielding a relative risk of 1.7 (95% confidence interval, 1.1 to 2.7). When cases and controls were compared directly, no statistically significant difference in cancer-free survival was found.
Griffin
M R
MR
Department of Medical Statistics and Epidemiology, Mayo Clinic, Rochester, MN 55905.
Stanson
A W
AW
Brown
M L
ML
Hauser
M F
MF
O'Fallon
W M
WM
Anderson
H M
HM
Kazmier
F J
FJ
Melton
L J
LJ
D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008910:Minnesota; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality; D010690:Phlebography; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D011877:Radionuclide Imaging; D012307:Risk Factors; D013924:Thrombophlebitis / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D013997:Time Factors