Azathioprine-induced in vitro inhibition of prostaglandin E2 production by rabbit retina.
Although much work exists concerning the clinical and immunosuppressive effects of azathioprine, little is known of the mechanism of action of this drug. The present study reports that azathioprine at the concentrations of 0.1 and 0.05 micrograms/ml causes a significant suppression of in vitro prostaglandin E2 production by rabbit retinas. However, at concentrations below (0.01 microgram/ml) or above (1,10 micrograms/ml) azathioprine was not inhibitory effect. These results suggest a dose-dependent inhibitory effect of azathioprine on prostaglandin E2 production.
Dottan
S
S
Medical Corps, Israel Defense Forces (Dottan), Tel Hashomer.
Glerstein
S
S
Naveh
N
N
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D011458:Prostaglandins E / Q000096:biosynthesis*; D011817:Rabbits; D012160:Retina / Q000378:metabolism*; D014605:Uveitis / Q000209:etiology
D011458:Prostaglandins E; D001379:Azathioprine; D007213:Indomethacin