Effect of lead toxicity on the organ concentration of glutathione and glutathione-related free amino acids in the chick.
Total non-protein sulfhydryl (NPSH) and glutathione (GSH) concentrations in liver and kidney and GSH-related free amino acid concentrations in liver, kidney and plasma were examined in the chick following intoxication with 2000 ppm dietary lead (Pb). After 3 weeks, NPSH content was significantly (P less than 0.05) increased by Pb in both liver and kidney while only liver GSH was increased by Pb treatment. The concentrations of glutamate, glycine and methionine were elevated in liver by Pb while glycine, cysteine and cystathionine concentrations were increased in the kidney. In plasma, Pb significantly decreased cysteine, taurine and cystathionine concentrations.
McGowan
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Food Science and Human Nutrition Department, University of Florida, Gainesville 32611.
Donaldson
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D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D002645:Chickens; D005978:Glutathione / Q000032:analysis*; D007668:Kidney / Q000032:analysis*; D007854:Lead / Q000633:toxicity*; D008099:Liver / Q000032:analysis*; D008297:Male; D013438:Sulfhydryl Compounds / Q000032:analysis
D000596:Amino Acids; D013438:Sulfhydryl Compounds; D007854:Lead; D005978:Glutathione