title: Sexual activity increases plasma concentrations of cholecystokinin octapeptide and offsets hunger in male rats.
abstract: Male rats deprived of food for 48 h ignored food pellets immediately after ejaculating with a sexually receptive female rat as did males tested 5 min after i.p. injection of 5 micrograms cholecystokinin octapeptide (CCK-8) or males which had consumed food pellets for 1 h. The concentration of CCK-8 in plasma was increased to comparable levels (10.1 +/- 3.8 (S.E.M.); 11.3 +/- 3.7 and 7.2 +/- 0.5 pmol/l respectively, compared with 1.2 +/- 0.3 pmol/l for NaCl-injected controls) under each of these conditions, whereas the concentration of gastrin increased only after food consumption (18.4 +/- 3.8; 17.7 +/- 5.4 and 54.3 +/- 7.0 pmol/l respectively, compared with 21.5 +/- 2.1 pmol/l for NaCl-injected controls). The effect of ejaculation on the latency to starting to eat was partially reversed by i.p. injection of 50 mg of the CCK-8 antagonist proglumide, but neither treatment with proglumide or CCK-8 nor consumption of food affected the display of sexual behaviour. The results support the suggestion that CCK-8 is a 'satiety peptide' in the rat.
authors: Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
authors: A
authors: A
authors: Lindén
authors: S
authors: S
authors: Hansen
authors: I
authors: I
authors: Bednar
authors: G
authors: G
authors: Forsberg
authors: P
authors: P
authors: Södersten
authors: K
authors: K
authors: Uvnäs-Moberg
mesh_terms: D000818:Animals; D005755:Gastrins / Q000097:blood; D006815:Hunger / Q000187:drug effects; D008297:Male; D011377:Proglumide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects; D012844:Sincalide / Q000097:blood* / Q000494:pharmacology
chemical_list: D005755:Gastrins; D011377:Proglumide; D012844:Sincalide