Theophylline clearance during and after mild upper respiratory infection.
Theophylline clearance was estimated by a single-sample technique in 19 subjects with acute clinical respiratory infections. Mean (+/- SD) theophylline clearance during acute illness was 0.044 +/- 0.011 L X h-1 X kg-1 compared to 0.043 +/- 0.012 L X h-1 X kg-1 1 month later. In a subset of five subjects, single-sample clearance estimates were not different from standard multi-sample clearance estimates. Mild upper respiratory infection does not appear to alter theophylline clearance in adults.
Bachmann
K
K
Department of Pharmacology, University of Toledo College of Pharmacy, Ohio 43606.
Schwartz
J
J
Martin
M
M
Jauregui
L
L
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000378:metabolism*; D013806:Theophylline / Q000493:pharmacokinetics*
D013806:Theophylline