title: Effects of trapezoid body and superior olive lesions on choline acetyltransferase activity in the rat cochlear nucleus.
abstract: Using a microdissection and quantitative microassay approach, choline acetyltransferase activities were mapped in the cochlear nuclei of rats having either transection of the trapezoid body or destruction of the superior olivary complex on one side in the brain stem. Lateral trapezoid body transection resulted in dramatic loss of choline acetyltransferase activity in all parts of the ipsilateral cochlear nucleus, while more medial transection had little effect. Destruction of the superior olivary complex resulted in dramatic loss of choline acetyltransferase activity in the ipsilateral cochlear nucleus, and detectable loss also contralaterally. The results suggest that most of the centrifugal cholinergic projections to the rat cochlear nucleus derive from or traverse the vicinity of the superior olivary complex bilaterally and enter the cochlear nucleus ventrally from the region of the trapezoid body.
authors: Dept. of Physiology, Oral Roberts University, Tulsa, OK 74171.
authors: D A
authors: DA
authors: Godfrey
authors: J L
authors: JL
authors: Park-Hellendall
authors: J D
authors: JD
authors: Dunn
authors: C D
authors: CD
authors: Ross
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D003056:Cochlear Nerve / Q000201:enzymology / Q000502:physiology*; D003714:Denervation; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D009847:Olivary Nucleus / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D002795:Choline O-Acetyltransferase; D001219:Aspartate Aminotransferases