title: Serum concentrations of salicylate and naproxen during concurrent therapy in patients with rheumatoid arthritis.
abstract: The kinetic interaction between salicylate and naproxen was investigated in 25 rheumatoid arthritis patients. Kinetic interactions were tested in serum after patients had been on each drug regimen for 1 month. Salicylate decreased serum naproxen concentration from 89.5 mg/liter to 65.9 mg/liter (P less than 0.001) and increased serum naproxen clearance by 56%. Naproxen had minimal effect on serum salicylate concentrations.
authors: Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City.
authors: D E
authors: DE
authors: Furst
authors: E
authors: E
authors: Sarkissian
authors: K
authors: K
authors: Blocka
authors: S
authors: S
authors: Cassell
authors: S
authors: S
authors: Dromgoole
authors: E R
authors: ER
authors: Harris
authors: J M
authors: JM
authors: Hirschberg
authors: N
authors: N
authors: Josephson
authors: H E
authors: HE
authors: Paulus
mesh_terms: D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D002794:Choline / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use; D004311:Double-Blind Method; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009288:Naproxen / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011897:Random Allocation; D012459:Salicylates / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D012459:Salicylates; D009288:Naproxen; C017959:choline magnesium trisalicylate; D002794:Choline