[Protective action of pantetine on the denervated stomach].
Bilateral subdiaphragmal vagotomy was performed in sexually-mature Wistar male rats. To prevent neurodystrophic processes in the stomach mucous membrane some animals were injected pantetine subcutaneously at a dose of 30 mg/kg 5 times daily for 10 days. Pantetine injected to vagotomized animals decreased destructive lesions in the stomach mucous membrane. Enhanced biosynthesis and the inhibition of gastrin and serotonin release from G and Ec cells respectively have been observed. The results obtained substantiate the use of pantetine for the pharmacological correction of postoperative complications in patients after vagotomy.
Fedchenko
S N
SN
Moiseenok
A G
AG
D000818:Animals; D008297:Male; D010204:Pantetheine / Q000627:therapeutic use*; D051381:Rats; D013270:Stomach / Q000187:drug effects / Q000294:innervation* / Q000473:pathology; D013438:Sulfhydryl Compounds / Q000627:therapeutic use*; D014628:Vagotomy / Q000009:adverse effects*
D013438:Sulfhydryl Compounds; D010204:Pantetheine
Protektivnoe deĭstvie pantetina na denervirovannyĭ zheludok.