Effect of PSK on prohibited immunity of splenectomized mice.
The effect of PSK (Krestine, an anti-tumor drug prepared from Coriolus versicolor) on splenectomized experimental animals was investigated. Splenectomy was performed on both a tumor-free control group and a tumor-bearing group. The administration of PSK on the splenectomized control group significantly increased the immune state of the host. In the case of the tumor-bearing group, administration of PSK resulted in restoration of the immune function as observed in the control group. Recovery of the immunological function was accelerated when tumor-bearing animals were splenectomized at the terminal stage. The results suggest that the immunomodulating effects of PSK developed at the time of the splenectomy resulted in anticancer activity.
Fujii
T
T
Kureha Chemical Industry Co., Ltd. Biomedical Research Laboratories, Tokyo, Japan.
Kano
T
T
Saito
K
K
Kobayashi
Y
Y
Iijima
H
H
Matsumoto
T
T
Yoshikumi
C
C
Taguchi
T
T
D000276:Adjuvants, Immunologic; D000818:Animals; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects*; D051379:Mice; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000628:therapy; D010853:Picryl Chloride; D011509:Proteoglycans / Q000494:pharmacology*; D012513:Sarcoma, Experimental / Q000276:immunology / Q000628:therapy; D013156:Splenectomy; D013997:Time Factors
D000276:Adjuvants, Immunologic; D011509:Proteoglycans; C010770:polysaccharide-K; D010853:Picryl Chloride