title: Scintigraphic evaluation of enterogastric reflux using 75Se-HCAT: methodology and first clinical observations.
abstract: The aim of this study was to assess the possibility of detecting enterogastric reflux (EGR) by 75Se-HCAT cholescintigraphy. The lowest detectable activity in the gastric area at different concentrations of the radiotracer in the gallbladder was preliminary measured both in a plastic phantom and in an in vivo model. Ten patients were studied after a single oral administration of 1480 KBq 75Se-HCAT. Gamma camera imaging was carried out for five consecutive days during both fasting and after meal ingestion. In our in vivo model an EGR corresponding to 1% of gallbladder content on day one and 8% on day five was detected. In three out of five patients in whom bile was present in the stomach at endoscopy, 75Se-HCAT cholescintigraphy demonstrated an EGR, while in three out of five patients in whom endoscopy was negative, 75Se-HCAT cholescintigraphy detected EGR either during fasting or after meal ingestion. As EGR is not constant, 75Se-HCAT may be a useful tracer of bile to detect EGR over a prolonged period of time and in different physiological conditions.
authors: Department of Nuclear Medicine, Ospedale Maggiore, Bologna, Italy.
authors: A
authors: A
authors: Furno
authors: G
authors: G
authors: Sciarretta
authors: G
authors: G
authors: Fagioli
authors: R
authors: R
authors: Pozzato
authors: P
authors: P
authors: Malaguti
mesh_terms: D001655:Bile Reflux / Q000000981:diagnostic imaging*; D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging*; D002763:Cholecystectomy; D004383:Duodenogastric Reflux / Q000000981:diagnostic imaging*; D004435:Eating; D005743:Gastrectomy; D006801:Humans; D011183:Postoperative Complications / Q000000981:diagnostic imaging; D011829:Radiation Dosage; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012643:Selenium; D013656:Taurocholic Acid / Q000031:analogs & derivatives
chemical_list: D011868:Radioisotopes; D013656:Taurocholic Acid; C033638:23-seleno-25-homotaurocholic acid; D012643:Selenium