A new polymorphic pepsinogen locus (Pg-2) in the rat (Rattus norvegicus).
Only two types of pepsinogens, which are products of the Pg-1 locus, are present in rat urine. In gastric mucosa, however, additional pepsinogen isozymes are expressed. We have found a polymorphism for rat gastric mucosa pepsinogen using agarose gel electrophoresis. Some inbred rat strains expressed a pepsinogen band, while others did not. The trait was found to be controlled by a single autosomal locus. We tentatively designated the locus as Pg-2 with two alleles, Pg-2a for the one controlling presence of the band and Pg-2o for the one controlling absence. Linkage analysis using BN and TM strains revealed that Pg-2 was closely linked to Pg-1 (3.7 +/- 1.8 cM), and that it did not belong to LG I (Hbb and p), LG II (Acon-1 and Mup-1), LG IV (Hao-1 and Svp-1), LG V (Es-1 and Es-3), LG VI (Gc and h), LG IX (RT1), LG X (Fh and Pep-3), nor a LG containing Ahd-2 (as yet undetermined).
Hamada
S
S
Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, Japan.
Yamada
J
J
Bender
K
K
Adams
M
M
D000818:Animals; D002874:Chromosome Mapping; D005753:Gastric Mucosa / Q000201:enzymology; D010435:Pepsinogens / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*
D010435:Pepsinogens