Effect of metabolic acidosis on pulmonary microcirculation in the cat.
Using a new X-ray TV system, we studied the effects of metabolic acidosis, produced by intravenous injection of lactic acid, on internal diameter (ID; 100-500 micron), flow velocity, and volume flow in pulmonary microcirculation of anesthetized cats. We found that metabolic acidosis decreased the ID of arteries by 21%, whereas it increased flow velocity by 28% but not volume flow.
Sada
K
K
Department of Cardiac Physiology, National Cardiovascular Center Research Institute, Suita, Japan.
Shirai
M
M
Ninomiya
I
I
D000140:Acidosis, Lactic / Q000503:physiopathology*; D000792:Angiography; D000818:Animals; D001783:Blood Flow Velocity; D002415:Cats; D008833:Microcirculation / Q000502:physiology; D011652:Pulmonary Circulation; D014655:Vascular Resistance; D014661:Vasoconstriction