Inadequate plasma concentrations in some high-dose methadone maintenance patients.
The author studied 18 heroin addicts who had been maintained on 80 mg/day of methadone and who abused drugs or alcohol. His findings suggest that in some cases of aberrant methadone metabolism, the dose can be raised to achieve plasma concentrations adequate to eliminate drug and alcohol abuse.
Tennant
F S
FS
UCLA School of Public Health.
D000284:Administration, Oral; D000328:Adult; D005260:Female; D006556:Heroin Dependence / Q000097:blood / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics
D008691:Methadone