Experimental gram-negative septicemia: thromboplastin generation in mononuclear phagocytes from different anatomical sites.
Rats were subjected to gram-negative septicemia induced by cecal perforation or were sham-operated. Thromboplastin values increased in blood monocytes (40-fold), peritoneal macrophages (115-fold) pleural macrophages (5-fold), splenic macrophages (3-fold), and lung alveolar macrophages (1.4-fold) in septic animals as compared to controls. In septic animals disseminated intravascular coagulation was evidenced by a significant (p less than 0.05) fall in fibrinogen, factor VII, X and platelets. A simultaneous and significant (p less than 0.05) decrease in thromboplastin content of tissue-specimens from lung and spleen was observed in rats with septicemia, whereas increased thromboplastin values were demonstrated in tissue-samples from cecum - the infectious focus. This might reflect mobilization of mononuclear phagocytes in favour of the site of infection.
Almdahl
S M
SM
Department of Surgery, University Hospital, Tromsø, Norway.
Osterud
B
B
D000818:Animals; D001779:Blood Coagulation Factors / Q000378:metabolism; D002465:Cell Movement; D004195:Disease Models, Animal; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology; D006090:Gram-Negative Bacteria; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D010529:Peritoneal Cavity / Q000166:cytology; D010994:Pleura / Q000166:cytology; D011650:Pulmonary Alveoli / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains; D018805:Sepsis / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000382:microbiology; D013154:Spleen / Q000166:cytology; D013925:Thromboplastin / Q000096:biosynthesis*; D014018:Tissue Distribution
D001779:Blood Coagulation Factors; D013925:Thromboplastin