Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture.
The dextrorotatory opioid derivatives, dextrorphan and dextromethorphan, can attenuate hypoxic injury in cortical cell cultures. This effect is concentration-dependent in the micromolar range, and not strongly stereospecific, as it can also be demonstrated with the levorotatory enantiomer of dextrorphan, levorphanol. The possibility that these clinically available compounds may have therapeutic utility in hypoxic or ischemic encephalopathy warrants further investigation.
Goldberg
M P
MP
Department of Neurology, Stanford University Medical Center, CA 94305.
Pham
P C
PC
Choi
D W
DW
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects* / Q000196:embryology; D003915:Dextromethorphan / Q000494:pharmacology*; D003917:Dextrorphan / Q000494:pharmacology*; D000860:Hypoxia / Q000473:pathology*; D007981:Levorphanol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051379:Mice; D009019:Morphinans / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*
D009019:Morphinans; D003917:Dextrorphan; D007981:Levorphanol; D003915:Dextromethorphan