Specific IgG antibodies to Dermatophagoides pteronyssinus and egg white--their changes with age.
Dermatophagoides pteronyssinus-specific and egg white-specific IgG in 232 children and 42 adults were measured by the RAST method using monoclonal anti-human IgG antibodies (HG2-25) as the secondary antibody. Changes in allergen-specific IgG with the age of the subjects were examined. Allergen-specific IgG antibody in standard serum was designated as 1,000 U/mL. Standard curves were made for each measurement and the levels of allergen-specific IgG of the sera were expressed in units (U). Dermatophagoides pteronyssinus-specific IgG increases from 9 months of age until adulthood. The atopic group showed higher mean values than the non-atopic group (r less than .001). Egg white-specific IgG reaches a peak around 3 to 4 years of age. After this, it declines until adulthood. These results suggest that age factors and allergen factors must be taken into consideration when evaluating allergen-specific IgG antibodies.
Nakano
H
H
Department of Pediatrics, Faculty of Medicine, Kyoto University, Japan.
Hosoi
S
S
Mikawa
H
H
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000276:immunology*; D000818:Animals; D000918:Antibody Specificity; D002648:Child; D002675:Child, Preschool; D004529:Egg White; D005512:Food Hypersensitivity / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis*; D007223:Infant; D008925:Mites / Q000276:immunology*; D011852:Radioallergosorbent Test
D007074:Immunoglobulin G