title: Isolation and bioactivity of new tanshinones.
abstract: Two new diterpenoids, designated neocryptotanshinone and isotanshinone IIB, have been isolated from "Tan-Shen," the root of Salvia miltiorrhiza, together with a known compound, danshexinkun A. Their structures are established by spectral and physical data. Isotanshinone IIB exhibits significant inhibitory activity in vitro on ADP- and collagen-induced aggregation.
authors: School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, R.O.C.
authors: A R
authors: AR
authors: Lee
authors: W L
authors: WL
authors: Wu
authors: W L
authors: WL
authors: Chang
authors: H C
authors: HC
authors: Lin
authors: M L
authors: ML
authors: King
mesh_terms: D045784:Abietanes; D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors; D003094:Collagen / Q000037:antagonists & inhibitors; D006801:Humans; D066298:In Vitro Techniques; D010616:Phenanthrenes / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis; D010974:Platelet Aggregation / Q000187:drug effects*
chemical_list: D045784:Abietanes; D010616:Phenanthrenes; C021751:tanshinone; D000244:Adenosine Diphosphate; D003094:Collagen