[Use of phospholipids to repair rat liver membranes during carbon tetrachloride poisoning].
The effect of phospholipid multilayer liposomes on the properties of endoplasmic reticular membranes has been studied in hepatic cells damaged with CCl4. It has been shown that the repair effect of phosphatidylcholine liposomes was manifested in vivo by normalization of phospholipid membrane composition, reduction in the degree of cytochrome P-450 inactivation, partial normalization of its hydroxylase activity and recovery of glucose-6-phosphatase activity. The degree of phosphatidylcholine unsaturation, and the introduction of antioxidants--SH-compounds, sphingomyelin, phosphatidyl inositol--into liposomes did not influence the efficacy of liposomes.
Dobrynina
O V
OV
Migushina
V L
VL
Shatinina
S Z
SZ
Boldanova
N B
NB
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D008081:Liposomes / Q000008:administration & dosage; D008099:Liver / Q000187:drug effects; D008297:Male; D010743:Phospholipids / Q000627:therapeutic use*; D051381:Rats
D008081:Liposomes; D010743:Phospholipids
Reparatsiia fosfolipidami membran pecheni krys pri otravlenii tetrakhlormetanom.