Oestrogen synthesis by the foetal rat testis in organ culture.
Testes from 19- to 21-day old rat foetuses were bisected and cultured in the presence of tritiated testosterone, androstenedione or dehydroepiandrosterone as precursors for oestrogen biosynthesis. Oestrone and oestradiol formed were identified by recrystallization to constant specific activity, and their conversion rate was determined after isotopic dilution. Both oestrogens formed from either precursor, their conversion rate being about 0.05% for oestradiol and 0.015% for oestrone.
Weniger
J P
JP
Laboratoire de Zoologie et d'Embryologie Expérimentale, Université Louis-Pasteur, Strasbourg, France.
Zeis
A
A
D000728:Androgens / Q000378:metabolism*; D000818:Animals; D002250:Carbon Radioisotopes; D004967:Estrogens / Q000096:biosynthesis*; D005333:Fetus; D008297:Male; D009924:Organ Culture Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000196:embryology* / Q000378:metabolism; D014316:Tritium
D000728:Androgens; D002250:Carbon Radioisotopes; D004967:Estrogens; D014316:Tritium