title: [Urticaria pigmentosa--an obligate systemic disease? Results of nuclear medicine studies and etiopathogenetic significance].
abstract: The objective of the present investigation was to establish the frequency of systemic spreading of urticaria pigmentosa by means of bone and bone marrow scintigraphy as a noninvasive imaging technique with a low radiation exposure. Bone scintigraphy: Seven of nine patients investigated showed diffuse and focal nuclide accumulation. After exclusion of other causes by reference to the case history and the clinical and chemical laboratory findings, these nuclide accumulations were regarded as mastocytosis-specific in accordance with the atypical localization. Bone-marrow scintigraphy: All the patient investigated showed a peripheral expansion of the bone marrow. This must be interpreted as an expansion of the macrophages of the bone marrow on the basis of the method used. Since the mast cell is regarded as a more highly differentiated form of the same cell-type as macrophages/monocytes, on the basis of the scintigraphic results presented, urticaria pigmentosa can be regarded pathogenetically as a hyperplasia of the macrophages of the bone marrow organ, with increased differentiation in mast cells. The extent of this differentiation and its pathological quality then determine the clinical signs and symptoms (cutaneous, systemic, or malignant mastocytosis). Urticaria pigmentosa thus has the character of a systemic disease.
authors: Abteilung I des Zentrums der Dermatologie und Venerologie, des Klinikums der Johann-Wolfgang-Goethe-Universität Frankfurt/Main.
authors: S
authors: S
authors: Sollberg
authors: H
authors: H
authors: Holzmann
authors: W C
authors: WC
authors: Marsch
authors: P
authors: P
authors: Altmeyer
authors: G
authors: G
authors: Hör
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000000981:diagnostic imaging*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008415:Mastocytosis / Q000000981:diagnostic imaging; D008875:Middle Aged; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives; D014582:Urticaria Pigmentosa / Q000000981:diagnostic imaging*
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013669:Technetium Tc 99m Medronate
vernacular_title: Urticaria pigmentosa--eine obligate Systemerkrankung? Nuklearmedizinische Untersuchungsergebnisse und ihre ätiopathogenetische Deutung.