Threshold dose-response models in toxicology.
After a brief discussion of the threshold concept in toxicology, we consider models for the estimation of thresholds in the case where the observed response is binary or quantal. A generalization of the four-parameter Tukey-lambda family of distributions is proposed as a useful class of models for threshold estimation. Properties of these models are discussed and the process of model fitting and evaluation is illustrated using a number of data sets. The discussion includes consideration of background or spontaneous response, and comparison with other models. One of these is the linear-plateau or hockey-stick model, which has been used in a number of toxicological studies.
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Division of Biostatistics, School of Medicine and Dentistry, University of Rochester, New York 14642.
D000818:Animals; D001699:Biometry; D002246:Carbon Disulfide / Q000633:toxicity; D001517:Coleoptera; D004305:Dose-Response Relationship, Drug; D008954:Models, Biological; D014116:Toxicology
D002246:Carbon Disulfide