Excess HLA antigens after transfusion of sickle cell patient with AIDS.
A woman with sickle cell-hemoglobin C disease developed the acquired immunodeficiency syndrome (AIDS), possibly as the result of blood transfusions administered 4 years earlier. Three months after subsequent transfusions, she had excess HLA-A and DR antigens (triplets) on her circulating lymphocytes. Three of her first-degree relatives were HLA-typed, and none had excess antigens. Family studies also indicated that the patient had at least one HLA-A antigen that was probably not inherited. These findings suggest the possibility that transient hemopoietic engraftment can occur in transfused sickle cell patients with AIDS.
Castro
O
O
Department of Medicine, Howard University College of Medicine, Washington, D.C.
Alarif
L
L
Saxinger
C
C
Frederick
W
W
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology* / Q000628:therapy; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications / Q000276:immunology* / Q000628:therapy; D001803:Blood Transfusion; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008297:Male
D006680:HLA Antigens