[The main stages in the pharmacokinetic research on new substances].
The main stages in studying pharmacokinetics of new drugs are discussed. They include: development of a micromethod for determining drugs in biological objects, estimation of drug stability in biological objects on storage, evaluation of drug distribution coefficients, investigation of drug solubility rate, drug binding to plasma proteins and erythrocytes, studying of drug metabolism in vitro and in vivo, investigation of drug kinetics in test tissues after single and repeated administrations, estimation of drug bioavailability, investigation of drug excretion and distribution in organs and tissues, determination of concentration-effect relationships in test tissues and studying of drug pharmacokinetics in models simulating pathological processes.
Berliand
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AS
D000818:Animals; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004355:Drug Stability; D010599:Pharmacokinetics; D011485:Protein Binding; D012107:Research Design; D012995:Solubility
Osnovnye étapy issledovaniia farmakokinetiki substantsiĭ novykh preparatov.