Triple antibiotics for the treatment of infected joint replacements. Case report and commentary.
Combination antibiotics are frequently used in the treatment of infected joint arthroplasties to achieve synergistic activity against the infecting organisms. A case is presented in which triple antibiotic therapy was used in the treatment of an infected hip arthroplasty. The antibiotic combination proved to have an antagonistic effect despite documented sensitivities to the individual drugs. Serum antimicrobial assays are recommended in the treatment of all prosthetic joint infections.
Shaw
J A
JA
Milton S. Hershey Medical Center, Pennsylvania State University, Department of Surgery, Hershey 17033.
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004336:Drug Antagonism; D004338:Drug Combinations; D006621:Hip Joint / Q000601:surgery; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations