Synthetic cephalosporins. II. The synthesis and oral activity of 7-[R-2-amino-2-(3-chloro-4-hydroxyphenyl)acetamido]-3-methylthio-3- cephem-4-carboxylic acid and related compounds.
A series of 3-methylthio-3-cephem-4-carboxylic acids were prepared to test their antibacterial activities, and 7-[R-2-amino-2-(3-chloro-4-hydroxyphenyl)acetamido]-3-methylthio-3-ce phe m-4- carboxylic acid was found to be a new orally active antibiotic.
Sakagami
K
K
Central Research Laboratories, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
Watanabe
T
T
Fukatsu
S
S
Nitta
H
H
Hatanaka
M
M
Ishimaru
T
T
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000633:toxicity; D002506:Cephalexin / Q000633:toxicity; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000633:toxicity; D051379:Mice; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002506:Cephalexin