title: Comparative effects of X irradiation on the testes of adult Sprague-Dawley and Wistar rats.
abstract: The response of the testes of two strains of adult rats (Sprague-Dawley and Wistar) to graded single doses and split doses of 230 kVp X rays has been investigated. A marked difference was noted between the strains in the response of the clonogenic spermatogonia to irradiation, as measured histologically by the repopulation index. Single-dose response curves derived for these cells in the Sprague-Dawley strain had a much larger shoulder (up to about 4-5 Gy) than for the Wistar (less than 2 Gy). Split-dose studies revealed that this difference may partly be explained by a greater repair capacity in the cells of the Sprague-Dawley strain. Changes in serum FSH concentrations mirrored the changes in clonogenic spermatogonial survival following split doses of radiation.
authors: Radiotherapy Research Unit, Institute of Cancer Research, Sutton, Surrey, United Kingdom.
authors: J I
authors: JI
authors: Delic
authors: O K
authors: OK
authors: Schlappack
authors: J R
authors: JR
authors: Harwood
authors: J A
authors: JA
authors: Stanley
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D008297:Male; D011836:Radiation Tolerance; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013737:Testis / Q000528:radiation effects*