Increased presence of common systemic lupus erythematosus (SLE) anti-DNA idiotypes (16/6 Id, 32/15 Id) is induced by procainamide.
Sixty-seven patients on treatment with procainamide were examined for the presence of two common idiotypes of anti-DNA antibodies (16/6 Id and 32/15 Id). These idiotypes have been shown previously to have clinical relevance in patients with systemic lupus erythematosus (SLE). An enzyme-linked immunosorbent assay (ELISA) with rabbit anti-Id antibodies revealed increased concentrations of the 16/6 Id and 32/15 Id in 25 (37%) and 16 (24%) patients, respectively. Five of eight patients with drug-induced lupus had elevated titers of both idiotypes. A high correlation (R = 0.56, P less than 0.001 for 16/6 Id) was found between Id levels and anti-single-stranded DNA (ssDNA) antibody titers and between 16/6 Id titers and antihistone antibodies (IgG, R = 0.43; IgM, R = 0.25). It seems that procainamide, a component known to be associated with drug-induced lupus, may induce an increased production of common anti-DNA idiotypes in apparently normal subjects.
Shoenfeld
Y
Y
Corob Research Center, Department of Medicine D, Soroka Medical Center, Beer-Sheva, Israel.
Vilner
Y
Y
Reshef
T
T
Klajman
A
A
Skibin
A
A
Kooperman
O
O
Kennedy
R C
RC
D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D000936:Antigen-Antibody Complex; D004247:DNA / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000032:analysis*; D007136:Immunoglobulins / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000276:immunology; D011342:Procainamide / Q000009:adverse effects*
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D006514:Hepatitis B Surface Antigens; D007130:Immunoglobulin Idiotypes; D007136:Immunoglobulins; D004247:DNA; D011342:Procainamide