title: The effect of nitrite on 14C-sulphathiazole (4-amino-N-2-thiazolyl[U-14C]benzenesulphonamide) metabolism in the rat.
abstract: 1. Rats given a meal containing 613 p.p.m. of 14C-sulphathiazole (4-amino-N-2-thiazolyl[14C]benzenesulphonamide) excreted less 14C-activity in urine and more 14C-activity in faeces as nitrite in the meal was increased (0, 10, 100 or 1000 p.p.m.). As nitrite in the meal was increased from 0 to 1000 p.p.m. the total 14C-residues in the gastrointestinal tract six hours after dosing increased, but decreased in other tissues. 2. High nitrite in the meal resulted in increased methanol insoluble 14C-activity in the gastrointestinal tract but had little or no effect on the methanol-insoluble activity in liver and blood. 3. Conversion of 14C-sulphathiazole to 14C-desaminosulphathiazole (N-2-thiazolyl[U-14C]benzenesulphonamide) in the rat was greatly increased by nitrite in the meal.
authors: Department of Biochemistry, North Dakota State University, Fargo 58105.
authors: P A
authors: PA
authors: Nelson
authors: G D
authors: GD
authors: Paulson
authors: V J
authors: VJ
authors: Feil
mesh_terms: D000818:Animals; D001711:Biotransformation; D004064:Digestive System / Q000378:metabolism; D005243:Feces / Q000032:analysis; D008099:Liver / Q000378:metabolism; D008297:Male; D009573:Nitrites / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D000077589:Sulfathiazole; D013432:Sulfathiazoles / Q000097:blood / Q000378:metabolism* / Q000652:urine
chemical_list: D009573:Nitrites; D013432:Sulfathiazoles; D000077589:Sulfathiazole