Gastric hypoacidity as a risk factor for gastric and other cancers.
Evidence is presented and discussed to test the hypothesis that the excess risk of gastric cancer observed in patients with decreased gastric acidity is caused by metabolites of nitrite, possibly N-nitroso compounds.
Caygill
C P
CP
PHLS-Communicable Diseases Surveillance Centre, London, UK.
Leach
S A
SA
Kirkham
J S
JS
Northfield
T C
TC
Hall
C N
CN
Hill
M J
MJ
D000126:Achlorhydria / Q000209:etiology / Q000378:metabolism*; D000752:Anemia, Pernicious / Q000150:complications; D005743:Gastrectomy; D005750:Gastric Juice / Q000032:analysis* / Q000382:microbiology; D006801:Humans; D009566:Nitrates / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D010437:Peptic Ulcer / Q000150:complications; D011183:Postoperative Complications / Q000378:metabolism; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000209:etiology* / Q000401:mortality
D009566:Nitrates; D009573:Nitrites