Effect of anemia on tumor radiosensitivity under normo and hyperbaric conditions.
The effect of chronic anemia on tumor radiosensitivity in a murine tumor has been investigated. Anemia was induced by bilateral kidney irradiation given several months before tumor implantation. Anemic, anemic transfused, and normal non-anemic age-matched tumor bearing animals were irradiated with X rays (2 F/24 hr) either in air, air plus misonidazole, or under hyperbaric oxygen. The most resistant response was that of tumors grown in normal mice treated in air. Anemia produced an increase in radiosensitivity which was further enhanced by red blood cell replacement. The most sensitive overall response was seen in the anemic-transfused group treated with HBO.
Rojas
A
A
Cancer Research Campaign, Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, U.K.
Stewart
F A
FA
Smith
K A
KA
Soranson
J A
JA
Randhawa
V S
VS
Stratford
M R
MR
Denekamp
J
J
D000230:Adenocarcinoma / Q000150:complications / Q000532:radiotherapy*; D000388:Air; D000740:Anemia / Q000150:complications* / Q000209:etiology / Q000628:therapy; D000818:Animals; D001803:Blood Transfusion; D002908:Chronic Disease; D005260:Female; D006931:Hyperbaric Oxygenation; D007668:Kidney / Q000528:radiation effects; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000150:complications / Q000532:radiotherapy*; D051379:Mice; D008808:Mice, Inbred CBA; D008920:Misonidazole / Q000008:administration & dosage; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage; D013997:Time Factors
D008920:Misonidazole