Action of acetaldehyde on glucose metabolism of newborn and adult erythrocytes.
This paper reports the effect of acetaldehyde on erythrocytes (RBC) of human adults and newborns. Acetaldehyde increases glucose consumption in adult RBC, but has no effect on that of newborn RBC. The compound stimulates the hexose monophosphate shunt and decreases the pyruvate production of the two RBC suspensions. In newborn RBC, acetaldehyde slightly modifies triose-P and fructose-1,6-bisphosphate but has no effect on the ATP/ADP ratio and glucose-1,6-bisphosphate content, which change markedly in adult RBC. Analysis of aldehyde dehydrogenase reveals nearly one half of enzyme activity in newborn RBC. The data indicate that in both adult and newborn RBC, acetaldehyde causes an intracellular reduced state, but the newborn cells take advantage of their greater pyruvate production for complete removal of the exceeding NADH equivalents.
Ninfali
P
P
Institute of Biological Chemistry, University of Urbino, Italy.
Palma
F
F
Piacentini
M P
MP
Fornaini
G
G
D019794:2,3-Diphosphoglycerate; D000079:Acetaldehyde / Q000494:pharmacology*; D000244:Adenosine Diphosphate / Q000097:blood; D000255:Adenosine Triphosphate / Q000097:blood; D000328:Adult; D000444:Aldehyde Dehydrogenase / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005312:Fetal Blood / Q000187:drug effects / Q000378:metabolism*; D005635:Fructosediphosphates / Q000097:blood; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives*; D005958:Glucosephosphates / Q000097:blood; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D009249:NADP / Q000097:blood; D010084:Oxidation-Reduction
D001786:Blood Glucose; D004163:Diphosphoglyceric Acids; D005635:Fructosediphosphates; D005958:Glucosephosphates; D019794:2,3-Diphosphoglycerate; D009249:NADP; D019298:Glucose-6-Phosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; C016473:glucose-1,6-bisphosphate; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde; C029063:fructose-1,6-diphosphate