title: Acute myocardial infarct imaging with indium-111-labeled monoclonal antimyosin Fab.
abstract: Indium-111 monoclonal antimyosin Fab scintigraphy was used to detect myocardial necrosis in 52 of 54 patients (96.3%) with acute myocardial infarction. Infarcts were visualized when coronary arteries were persistently occluded (n = 10), became patent after thrombolysis (n = 33), or became patent after spontaneous reperfusion (n = 7). Posteroinferolateral visualizations were obtained in two patients with clinical and enzymatic evidence of infarction but normal electrocardiograms. Of the two patients in whom no infarcts were visualized, one had an anterior myocardial infarct. This patient underwent successful thrombolytic therapy, with attendant minimization of creatine kinase release. The other patient had a small, nonreperfused inferior myocardial infarct. Five patients with a history of remote infarction and acute necrosis showed antimyosin uptake only in regions concordant with the acute episodes of infarction, and radiolabeled antimyosin Fab localized in neither old infarcts nor normal, noninfarcted myocardium. Antimyosin Fab scintigraphy, thus, appears to be a highly specific means of delineating necrotic myocardium, at least in this limited and selected group of patients.
authors: Cardiac Unit, Massachusetts General Hospital, Boston 02114.
authors: B A
authors: BA
authors: Khaw
authors: T
authors: T
authors: Yasuda
authors: H K
authors: HK
authors: Gold
authors: R C
authors: RC
authors: Leinbach
authors: J A
authors: JA
authors: Johns
authors: M
authors: M
authors: Kanke
authors: M
authors: M
authors: Barlai-Kovach
authors: H W
authors: HW
authors: Strauss
authors: E
authors: E
authors: Haber
mesh_terms: D000911:Antibodies, Monoclonal; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007205:Indium Radioisotopes; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D009218:Myosins / Q000276:immunology*; D011877:Radionuclide Imaging
chemical_list: D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D007205:Indium Radioisotopes; D009218:Myosins