Interferon beta 1, an intermediate in the tumor necrosis factor alpha-induced increased MHC class I expression and an autocrine regulator of the constitutive MHC class I expression.
In conclusion, our observations indicate that the constitutive MHC class I expression is regulated by autocrine production of IFN-beta 1. TNF-alpha acts as an enhancer of the autocrine production of IFN-beta 1, and consequently as an enhancer of the MHC class I expression and viral protection.
Leeuwenberg
J F
JF
Department of Surgery, University of Limburg, Maastricht, The Netherlands.
van Damme
J
J
Jeunhomme
G M
GM
Buurman
W A
WA
D000906:Antibodies; D002460:Cell Line; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006680:HLA Antigens / Q000096:biosynthesis*; D006706:Homeostasis; D006801:Humans; D007370:Interferon Type I / Q000276:immunology / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D000906:Antibodies; D006680:HLA Antigens; D007370:Interferon Type I; D014409:Tumor Necrosis Factor-alpha