The human placental alkaline phosphatase gene and related sequences map to chromosome 2 band q37.
A human placental alkaline phosphatase (PLAP) cDNA was isolated from a lambda gt 10 library of the cell line HEp-2. Southern blots probed with a fragment of the cDNA clone showed that the human genome may contain more than one PLAP-related sequence. The PLAP probe showed person-to-person variation in banding pattern with a number of enzymes. Using a panel of human/rodent somatic cell hybrids the PLAP sequences were mapped to chromosome 2. In situ hybridization confirmed this assignment and localized the gene(s) to chromosome 2 band q37.
Martin
D
D
Imperial Cancer Research Fund, Lincoln's Inn Fields, London.
Tucker
D F
DF
Gorman
P
P
Sheer
D
D
Spurr
N K
NK
Trowsdale
J
J
D000469:Alkaline Phosphatase; D000818:Animals; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D004247:DNA; D058851:GPI-Linked Proteins; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D007527:Isoenzymes / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D011110:Polymorphism, Genetic
D058851:GPI-Linked Proteins; D007527:Isoenzymes; D004247:DNA; D000469:Alkaline Phosphatase; C019839:alkaline phosphatase, placental