[Characteristics of the action of tetrapeptidamide on the body in short- and long-term administration].
It has been elucidated that the structures of the motor system of the rabbit and rat brain undergo significant alterations in monoamine metabolism 30 min after the administration of the synthetic enkephalin analogue Tyr-D-Ala-Gly-Phe-NH2 and in acetylcholinesterase activity and protein metabolism on the 3rd-6th day. It i suggested that a prolonged tetrapeptidamine-induced change in the motor functions may be due to a specific response on the part of the corticosubcortical structures of the motor systems.
Gershteĭn
L M
LM
Dovedova
E L
EL
Khudoerkov
R M
RM
Sergutina
A V
AV
D000110:Acetylcholinesterase / Q000378:metabolism; D000626:Aminopeptidases / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D004745:Enkephalins / Q000494:pharmacology*; D006651:Histocytochemistry; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000201:enzymology; D009842:Oligopeptides / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004745:Enkephalins; D009419:Nerve Tissue Proteins; D009842:Oligopeptides; C037379:tyrosyl alanyl-glycyl-phenylalaninamide; D008995:Monoamine Oxidase; D000110:Acetylcholinesterase; D000626:Aminopeptidases
Osobennosti deĭstviia tetrapeptidamida na organizm pri ego kratkosrochnom i dlitel'nom primenenii.