Bremazocine-induced urination in rats of different sizes.
The increased urine output after injection of the kappa agonist bremazocine was determined in rats of various body weights. Rats of all sizes were sensitive to the diuretic effect of bremazocine. The total diuretic effect was greater in heavier animals. The urine output plateaued between 4-5 ml/100 g body weight irrespective of body weight at the higher doses of bremazocine.
Leander
J D
JD
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001575:Benzomorphans / Q000494:pharmacology*; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D008297:Male; D009019:Morphinans / Q000494:pharmacology*; D051381:Rats; D014554:Urination / Q000187:drug effects*
D000700:Analgesics; D001575:Benzomorphans; D009019:Morphinans; C027248:bremazocine