[Effect of pentagastrin on the myoelectrical activity of the gastroduodenal area under M-cholinoreceptor activation and blockade].
Pentagastrin (0.1-1.0 microgram/kg) first depressed and then augmented the myoelectrical activity of the stomach and pylorus. Acetylcholine (500 mu k/kg) potentiated and atropine (0.2 mg/kg) inhibited the pentagastrin effects. The data suggest involvement of the cholinergic mechanism in the pentagastrin-induced myoelectrical gastroduodenal activity.
Shemerovskiĭ
K A
KA
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004386:Duodenum / Q000187:drug effects / Q000502:physiology; D004567:Electrodes, Implanted; D004576:Electromyography; D009130:Muscle, Smooth / Q000187:drug effects* / Q000502:physiology; D010418:Pentagastrin / Q000494:pharmacology*; D011708:Pylorus / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D011976:Receptors, Muscarinic / Q000187:drug effects* / Q000502:physiology; D013270:Stomach / Q000187:drug effects / Q000502:physiology
D011976:Receptors, Muscarinic; D001285:Atropine; D010418:Pentagastrin; D000109:Acetylcholine
Vliianie pentagastrina na mioélektricheskuiu aktivnost' gastroduodenal'noĭ zony v usloviiakh aktivatsii i blokady M-kholinoretseptorov.