Cimetidine increases serum mebendazole concentrations. Implications for treatment of hepatic hydatid cysts.
In eight patients (five with peptic ulcer disease and three with hydatid cysts), the [14C]-aminopyrine breath test (ABT) and maximum serum concentration of mebendazole following a dose of 1.5 g of mebendazole three times daily were determined before and after treatment with cimetidine (400 mg three times daily for 30 days). Serum mebendazole concentrations were measured in blood samples taken 2 h after each drug intake. Cimetidine lowered the 14CO2 specific activity (SA) at 1 h (P less than 0.01) and increased the maximum serum concentration of mebendazole (P less than 0.01). A significant correlation was found between SA at 1 h and the highest concentration of mebendazole before (r = -0.71, P less than 0.05) and after (r = -0.82, P less than 0.05) cimetidine ingestion. Combined administration of cimetidine and mebendazole resulted in the complete resolution of previously unresponsive hydatid cysts.
Bekhti
A
A
Institut de Médecine, Université de Liège, Hôpital de Bavière, Belgium.
Pirotte
J
J
D000328:Adult; D000632:Aminopyrine; D001944:Breath Tests; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D004444:Echinococcosis, Hepatic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008463:Mebendazole / Q000097:blood* / Q000627:therapeutic use; D008875:Middle Aged
D000632:Aminopyrine; D002927:Cimetidine; D008463:Mebendazole