title: Influence of various antibiotics on phagocytosis of Staphylococcus aureus by human polymorphonuclear leucocytes.
abstract: The influence of several new antibiotics on phagocytosis of two strains of Staphylococcus aureus by human polymorphonuclear leucocytes was studied with a radioisotopic method. The following antibiotics were tested in concentrations obtained in the serum after standard administration: gentamicin, netilmicin, amikacin, oxacillin, clindamycin, vancomycin, teicoplanin, rifampicin, ansamycin, coumermycin, enoxacin, ciprofloxacin, two new fluoro-quinolones CI 934 and RO 236240, and LY 146032 a new lipopeptidic antibiotic. Among them, only coumermycin significantly decreased phagocytosis, this was dependent on concentration, strain and source of the polymorphonuclear leucocytes.
authors: Service de Médecine et Laboratoire d'Investigation Clinique H.J. Tagnon, Brussels, Belgium.
authors: P
authors: P
authors: Van der Auwera
authors: M
authors: M
authors: Husson
authors: J
authors: J
authors: Frühling
mesh_terms: D049933:Aminocoumarins; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects*; D013045:Species Specificity; D013211:Staphylococcus aureus
chemical_list: D049933:Aminocoumarins; D000900:Anti-Bacterial Agents; D003374:Coumarins; C004628:coumermycin