title: [Pharmacokinetic bases for the drug-free prevention of drug-induced hepatitis in pulmonary tuberculosis patients].
abstract: The causes and frequency of occurrence of toxic hepatitides determined by isoniazid and rifampicin, were analysed in 551 patients with primary tuberculosis detected by clinical pharmacological methods. The intravenous mode of drug administration was shown to be indicated for prevention of isoniazid hepatitides in patients with a fast type of acetylation. Doses and methods of therapy with isoniazid and streptomycin leading to their high concentrations in the patients' body should be avoided to prevent liver affection with rifampicin. Since rifampicin hepatitides develop in persons with a slow type of acetylation, rifampicin and isoniazid with streptomycin should be injected with a 6-hour interval to prevent them.
authors: V A
authors: VA
authors: Koriakin
authors: G B
authors: GB
authors: Sokolova
authors: A V
authors: AV
authors: Ziia
authors: L R
authors: LR
authors: Zeliger
authors: A Ia
authors: AIa
authors: Ivleva
mesh_terms: D000107:Acetylation; D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000493:pharmacokinetics; D008875:Middle Aged; D012293:Rifampin / Q000008:administration & dosage / Q000493:pharmacokinetics; D013307:Streptomycin / Q000008:administration & dosage / Q000493:pharmacokinetics; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000150:complications* / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin
vernacular_title: Farmakokineticheskie osnovy bezmedikamentoznoĭ profilaktiki lekarstvennykh gepatitov u bol'nykh tuberkulezom legkikh.