Immunological effects of arsenic compounds on mouse spleen cells in vitro.
Immunological effects of arsenic compounds on mouse spleen cells in vitro were examined. Three kinds of arsenic compounds: sodium arsenite, sodium arsenate and dimethyl arsenic acid, at high doses, suppressed the plaque-forming cell response to sheep erythrocytes and the proliferative response to mitogens, whereas at low doses they enhanced both responses. And each of arsenic compounds differs in strengths at which the modulation effects on both responses were exerted. The strength was comparable to general toxicity of arsenic compounds.
Yoshida
T
T
Department of Microbiology, Tokai University School of Medicine, Japan.
Shimamura
T
T
Shigeta
S
S
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects*; D001149:Arsenates / Q000494:pharmacology*; D001151:Arsenic / Q000494:pharmacology*; D001152:Arsenicals / Q000494:pharmacology*; D018053:Arsenites; D002101:Cacodylic Acid / Q000494:pharmacology*; D002478:Cells, Cultured; D004306:Dose-Response Relationship, Immunologic; D007159:Immunologic Tests; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010835:Phytohemagglutinins / Q000494:pharmacology; D017670:Sodium Compounds; D013154:Spleen / Q000187:drug effects* / Q000276:immunology
D001149:Arsenates; D001152:Arsenicals; D018053:Arsenites; D008070:Lipopolysaccharides; D010835:Phytohemagglutinins; D017670:Sodium Compounds; C028784:phytohemagglutinin-P; C017947:sodium arsenite; C009277:sodium arsenate; D002101:Cacodylic Acid; D001151:Arsenic