Trisomy 12 in Burkitt-like lymphoma associated with acquired immunodeficiency syndrome.
Cytogenetic abnormalities have been reported in lymphoproliferative disorders, the most common of which is the t(8;14) translocation in Burkitt and Burkitt-like lymphomas. We report a 30-year-old homosexual male with Burkitt-like lymphoma and trisomy 12. This patient presented with persistent generalized lymphadenopathy and subsequently developed advanced lymphoma. Cell surface markers revealed a monoclonal pattern containing mu heavy chain and kappa light chain immunoglobulins. Cytogenetic analysis of bone marrow involved with lymphoma revealed an additional chromosome #12. Mitogen-stimulated cultures of peripheral blood showed a normal 46,XY karyotype. Trisomy 12 has been found in chronic lymphocytic leukemia and in other low-grade B-cell lymphoproliferative disorders, but not in Burkitt-like lymphoma.
Kosmo
M A
MA
Department of Medicine, UCLA School of Medicine 90024.
Mitsuyasu
R T
RT
Sparkes
R S
RS
Gale
R P
RP
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002051:Burkitt Lymphoma / Q000150:complications / Q000235:genetics* / Q000473:pathology; D002881:Chromosomes, Human, Pair 12; D006801:Humans; D007621:Karyotyping; D008297:Male; D014314:Trisomy