Translocation t(6;9)(p22.3;q34) in myelodysplastic syndrome--refractory anemia with excess blasts.
A 69-year-old male patient with refractory anemia with excess blasts (RAEB) was found to have a consistent chromosomal abnormality, t(6;9)(p22.3;q34), in the bone marrow and unstimulated peripheral blood cells. Twenty patients with t(6;9) and leukemia have been reported; some of them had a myelodysplastic syndrome (MDS) before developing overt ANLL. Our patient was still in the MDS stage when the t(6;9) was found. This result suggests that t(6;9) represents one of the pathways from MDS to leukemia in patients with ANLL.
Fan
Y S
YS
Department of Genetics and Endocrinology, Roswell Park Memorial Institute, Buffalo, NY 14263.
Raza
A
A
Schumer
J
J
Sait
S N
SN
Block
A W
AW
Snyderman
M
M
Sandberg
A A
AA
D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics*; D002871:Chromosome Banding; D002896:Chromosomes, Human, Pair 6; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007621:Karyotyping; D008297:Male; D014178:Translocation, Genetic