[Characteristics of Na+/H+ metabolism in the erythrocytes of rats with spontaneous hypertension].
The dependence of the rate of valinomycin-induced Na+/H+ erythrocyte metabolism on the extracellular K+ concentration has been investigated. It has been established that Na+/H+ metabolism in the erythrocytes of spontaneously hypertensive rats (SHR) is induced at higher [K+]o concentrations than in normotensive controls (WKY). The distinctions in the maximum rate of Na+/H+ metabolism were revealed only in SHR in pre-hypertensive stage (it was 20% lower than in WKY). It is suggested that the distinctions are determined by peculiarities of membrane cytoskeleton formation. The conclusion was confirmed in experiments on erythrocyte stability to orthovanadate effect.
Pokudin
N I
NI
Orlov
S N
SN
Postnov
Iu V
IuV
D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D004907:Erythrocyte Deformability / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006859:Hydrogen / Q000097:blood*; D006973:Hypertension / Q000097:blood*; D008297:Male; D011188:Potassium / Q000097:blood; D051381:Rats; D011918:Rats, Inbred SHR / Q000097:blood*; D011919:Rats, Inbred Strains / Q000097:blood*; D011921:Rats, Inbred WKY; D012964:Sodium / Q000097:blood*; D014634:Valinomycin / Q000494:pharmacology; D014638:Vanadates / Q000494:pharmacology
D014634:Valinomycin; D014638:Vanadates; D000584:Amiloride; D006859:Hydrogen; D012964:Sodium; D011188:Potassium
Osobennosti Na+/H+-obmena v éritrotsitakh krys so spontannoĭ gipertenzieĭ.