[Synthesis and choleretic activity of 3-(2-aryl-5R-benzimidazol-1-yl) butanoic acids].
Thirty 3-(2-aryl-5R-benzimidazol-1-yl)butanoic acids were prepared in order to evaluate substitution effects on the 2 and 5 positions of the heterocyclic ring upon the previously recorded choleretic activity of 3-(2-phenylbenzimidazol-1-yl)butanoic acid. A general choleretic activity is shown by the acids tested, which in several cases it is superior to that of the model compound and sometimes also to that of dehydrocholic acid.
Grella
G
G
Istituto di Chimica Farmaceutica e Tossicologica, Università di Sassari.
Paglietti
G
G
Sparatore
F
F
Manca
P
P
Satta
M
M
D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D001646:Bile / Q000378:metabolism; D002087:Butyrates / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D002756:Cholagogues and Choleretics / Q000138:chemical synthesis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001562:Benzimidazoles; D002087:Butyrates; D002756:Cholagogues and Choleretics
Sintesi ed attività coleretica di acidi 3-(2-aril-5R-benzimidazol-1-IL) butanoici.