[Effect of tuberculostatic agents and sodium succinate on the functional state of liver mitochondria in tuberculosis].
Effects of isoniazide and of new tuberculostatic drug of long-term action on functions of guinea pig liver mitochondria were studied in experimental tuberculosis. Significant changes in oxidative phosphorylation were found. The combination of sodium succinate with tuberculostatic drugs improved the bioenergetic functions of liver mitochondria under the conditions of antibacterial therapy of experimental tuberculosis.
Sokirko
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D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D013386:Succinates / Q000494:pharmacology*; D019802:Succinic Acid; D014376:Tuberculosis / Q000188:drug therapy / Q000378:metabolism*
D000995:Antitubercular Agents; D013386:Succinates; D019802:Succinic Acid
Vliianie tuberkulostaticheskikh preparatov i suktsinata natriia na funktsional'noe sostoianie mitokhondriĭ pecheni pri tuberkuleze.