Chemotherapeutic response of squamous cell carcinoma xenografts (subcutaneous and subrenal capsule assay).
Chemotherapeutic response of two squamous cell carcinoma xenograft lines (established from the primary and metastatic lesion of a tongue carcinoma) was studied using SC and SRC assays (as well as immunocompetent and -suppressed recipients in the latter assay). The two assays provided similar ranking of drugs, in the sense that in each instances two of the three (cyclophosphamide, 5-fluorouracil, vinblastine) most active agents were identical. The host response in immunocompetent recipients supports the need for histology to prove the proper quality of the implanted tumor tissue in order to be used for drug evaluation.
Rajnay
J
J
1st Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, Budapest, Hungary.
Kopper
L
L
Lapis
K
K
D000368:Aged; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013370:Subrenal Capsule Assay; D014747:Vinblastine / Q000627:therapeutic use
D014747:Vinblastine; D003520:Cyclophosphamide; D005472:Fluorouracil