title: Persistence of Campylobacter pyloridis despite healing of duodenal ulcer and improvement of accompanying duodenitis and gastritis.
abstract: Campylobacter pyloridis has been associated with antral gastritis and duodenal ulcer. To study the pathogenetic role of these organisms in duodenal ulcer, endoscopic biopsies, two from the first part of duodenum, four from antrum, and four from body and fundus, were taken before and after four weeks of cimetidine treatment (1.2 g/day) from 67 patients with active duodenal ulcer. The biopsies were examined for the presence and severity of any inflammation by two independent pathologists in the absence of any clinical information and for the occurrence and density of Campylobacter pyloridis by culture and Warthin-Starry stain. Before treatment, inflammation was present in 71.1, 100, and 25.8%, while the organisms were present in 34.3, 91.0, and 79.1% of the duodenal, antral, and fundal biopsies, respectively. With complete healing of duodenal ulcer, inflammation was present in 48.9, 98.2, and 30.2%, while the organisms were present in 25, 76.7, and 63.3% of the respective mucosae. With ulcer healing, duodenitis became significantly milder (P less than 0.05). With improvement of gastritis and duodenitis, there was no significant change in the occurrence and density of Campylobacter pyloridis. These findings indicate that healing of duodenal ulcer is not influenced by the presence of Campylobacter pyloridis, which is frequently found in the gastroduodenal mucosa of patients with duodenal ulcer, but does not appear to be associated with mucosal inflammation except in the antrum.
authors: Department of Medicine, University of Hong Kong, Queen Mary Hospital.
authors: W M
authors: WM
authors: Hui
authors: S K
authors: SK
authors: Lam
authors: P Y
authors: PY
authors: Chau
authors: J
authors: J
authors: Ho
authors: I
authors: I
authors: Lui
authors: C L
authors: CL
authors: Lai
authors: A S
authors: AS
authors: Lok
authors: M M
authors: MM
authors: Ng
mesh_terms: D000328:Adult; D002167:Campylobacter / Q000302:isolation & purification*; D002927:Cimetidine / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D004382:Duodenitis / Q000150:complications / Q000382:microbiology*; D004386:Duodenum / Q000382:microbiology; D005260:Female; D005748:Gastric Fundus / Q000382:microbiology; D005756:Gastritis / Q000150:complications / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011706:Pyloric Antrum / Q000382:microbiology; D014945:Wound Healing
chemical_list: D002927:Cimetidine