Liver microsomal membrane fluidity and lipid characteristics in vitamin A-deficient rats.
Rat liver microsomes (microsomal fraction) were isolated from vitamin A-deficient and -sufficient rats and analysed for membrane lipid characteristics. Membrane fluidity was found to be significantly decreased in microsomes from the vitamin A-deficient rats, but not in liposomes prepared from lipid extracts. Microsomes from vitamin A-deficient animals showed a significant decrease in C18:2, omega 6 and an increase in C22:5, omega 6 fatty acids.
Hamm
M W
MW
Department of Nutrition, Rutgers University, New Brunswick, NJ 08903.
Chan
V
V
Wolf
G
G
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis; D005454:Fluorescence Polarization; D007425:Intracellular Membranes / Q000378:metabolism; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D014802:Vitamin A Deficiency / Q000378:metabolism*
D005227:Fatty Acids; D008563:Membrane Lipids; D010743:Phospholipids; D002784:Cholesterol