[Comparative study of the effect of 3-carboxy-beta-carboline methylamide and diazepam on rat behavior].
The effects of benzodiazepine receptor agonist, diazepam, and inverse agonist, FG 7142, were examined. Strong antagonism between FG 7142 (10 mg/kg) and diazepam (1 mg/kg) activity was revealed in the open field test. On the other hand, both FG 7142 and diazepam inhibited isolation-induced intraspecies aggressive behaviour of rats. FG 7142 also reduced interspecies aggression of mouse-killing rats. The findings suggest that both diazepam and FG 7142 have antiaggressive properties in the isolation-induced aggression model, which are mediated by benzodiazepine receptors of the central nervous system.
Barsegian
G G
GG
Pliashkevich
Iu G
IuG
Demushkin
V P
VP
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002243:Carbolines / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D008297:Male; D051381:Rats
D002243:Carbolines; C035874:FG 7142; D003975:Diazepam
Sravnitel'noe izuchenie vliianiia metilamida 3-karboksi-beta-karbolina i diazepama na povedenie krys.