A biologically active parathyroid hormone-like substance secreted by an adenosquamous carcinoma of the transverse colon.
Recently, controversy has emerged as to whether paraneoplastic hypercalcemia in nonparathyroid tumors is due to ectopic production of a parathyroid hormone (PTH)-like substance. A sensitive DNA hybridization technique was unable to reveal PTH mRNA in a collection of such tumors. However, there is growing evidence that squamous differentiation of tumors favors the expression of PTH-like substances. We report the case of a 41-year-old woman with an adenosquamous carcinoma of colonic origin associated with severe hypercalcemia. The squamous component of liver metastases showed immunoreactivity with two different PTH antisera, suggesting the production of a PTH-like substance.
Moll
U M
UM
Department of Pathology, State University of New York, Stony Brook 11042.
Ilardi
C F
CF
Zuna
R
R
Phillips
M E
ME
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010281:Parathyroid Hormone / Q000378:metabolism* / Q000502:physiology
D010281:Parathyroid Hormone