title: Corneal test as a reliable method for detection of the delayed-type hypersensitivity reaction in mice.
abstract: Antigen solution could be injected into the cornea of sensitized mice using a fine needle and a stereoscopic dissecting microscope. The resulting corneal reaction was shown to be a reliable method in the detection and estimation of delayed-type hypersensitivity in mice that had been immunized with a water-in-oil emulsion containing an ovalbumin and a cell wall adjuvant. Unlike the delayed skin reaction in the ear lobe, this corneal reaction was not affected by a coexisting Arthus reaction.
authors: Department of Microbiology and Oral Microbiology, Osaka University Faculty of Dentistry, Japan.
authors: I
authors: I
authors: Morisaki
authors: T
authors: T
authors: Shimono
authors: N
authors: N
authors: Kohno
authors: D E
authors: DE
authors: Stewart-Tull
authors: S
authors: S
authors: Kotani
authors: H
authors: H
authors: Kitamura
mesh_terms: D000818:Animals; D000917:Antibody Formation; D003315:Cornea / Q000276:immunology* / Q000473:pathology; D006968:Hypersensitivity, Delayed / Q000175:diagnosis* / Q000276:immunology; D007114:Immunization; D007159:Immunologic Tests; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008813:Mice, Inbred ICR; D010047:Ovalbumin / Q000276:immunology*; D011237:Predictive Value of Tests
chemical_list: D010047:Ovalbumin