Peptide YY interacts with secretin and duodenal acidification to inhibit gastric acid secretion.
Previous studies have indicated that plasma levels of peptide YY (PYY) increase significantly after a meal. The purpose of this study was to characterize the interaction of PYY and secretin in the inhibition of gastric acid secretion, and to determine whether PYY can influence acid-induced inhibition of gastric acid secretion in conscious dogs. I.v. administration of PYY at 200 pmol/kg/h inhibited pentagastrin (1 microgram/kg/h)-stimulated gastric acid output (P less than 0.05). PYY further augmented i.v. secretin-induced inhibition of pentagastrin-stimulated gastric acid output by 32 +/- 7%, and intraduodenal hydrochloric acid-induced inhibition of pentagastrin-stimulated gastric acid output by 40 +/- 12%. The mean integrated release of secretin response to duodenal acidification (3.9 +/- 1.0 ng-[0-60] min/ml) was not affected by PYY (3.3 +/- 0.9 ng-[0-60] min/ml). The present study demonstrates that PYY can interact with secretin and duodenal acidification in an additive fashion to inhibit pentagastrin-stimulated gastric acid secretion. Our results suggest that several hormones that are released postprandially can interact with each other to inhibit gastric acid secretion.
Lluis
F
F
Department of Surgery, University of Texas Medical Branch, Galveston 11550.
Gomez
G
G
Fujimura
M
M
Greeley
G H
GH
Townsend
C M
CM
Thompson
J C
JC
D000818:Animals; D004285:Dogs; D004357:Drug Synergism; D004386:Duodenum / Q000378:metabolism; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006851:Hydrochloric Acid / Q000494:pharmacology*; D008297:Male; D010418:Pentagastrin / Q000037:antagonists & inhibitors; D019894:Peptide YY; D010455:Peptides / Q000494:pharmacology*; D011863:Radioimmunoassay; D012633:Secretin / Q000097:blood / Q000494:pharmacology*
D010455:Peptides; D019894:Peptide YY; D012633:Secretin; D010418:Pentagastrin; D006851:Hydrochloric Acid