Electrophysiological changes in the primary sensory neuron following subchronic soman and sarin: alterations in sensory receptor function.
Cats were administered soman or sarin either in a single high dose (1 mg/kg) with pretreatment or in multiple sublethal doses to determine whether these potent organophosphorus agents could produce a delayed neurotoxicity and what, if any, pathophysiological changes occurred in peripheral sensory receptors. Neither soman nor sarin, when administered as a single high dose, produced a delayed neurotoxicity as observed behaviorally for up to 60 days. There were also no observable signs of delayed neurotoxicity when these agents were administered in multiple doses. Functional tests of proprioceptors and mechanoreceptors were performed on the cats which received multiple sublethal doses of either soman or sarin. It was found that the discharge rates of muscle spindle primary endings were depressed while the discharge rates of secondary endings were facilitated following the administration of either soman or sarin. The discharge rates of slowly adapting type 1 mechanoreceptors were also depressed. The total number of identified mechanoreceptors was reduced in both the soman- and sarin-treated animals. Conduction velocities of several of the muscle spindle and mechanoreceptor afferents were significantly decreased. The alterations in muscle spindle function may be due to changes in the muscle resulting from acetylcholinesterase inhibition. Another explanation for the changes in both muscle spindle and mechanoreceptor function may be the direct effect of the organophosphorus agents on the afferents themselves, thus altering their excitability.
Goldstein
B D
BD
Department of Pharmacology & Toxicology, Medical College of Georgia, Augusta 30912-3368.
Fincher
D R
DR
Searle
J R
JR
D000818:Animals; D002415:Cats; D004553:Electric Conductivity; D004594:Electrophysiology; D008465:Mechanoreceptors / Q000187:drug effects / Q000502:physiology; D009475:Neurons, Afferent / Q000187:drug effects*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D011434:Proprioception / Q000187:drug effects; D012524:Sarin / Q000633:toxicity*; D011984:Sensory Receptor Cells / Q000187:drug effects* / Q000502:physiology; D012999:Soman / Q000633:toxicity*
D009943:Organophosphorus Compounds; D012999:Soman; D012524:Sarin