title: Adrenaline in various organs of the rat: its origin, location and diurnal fluctuation.
abstract: In order to examine the origin and location of adrenaline in peripheral organs of mammals, adrenaline and noradrenaline were measured in several organs of the rat after adrenalectomy, guanethidine treatment and imipramine injection. One week after bilateral adrenalectomy, adrenaline disappeared almost completely from the heart, spleen and submaxillary gland. Chronic administration of guanethidine caused decreases in both noradrenaline and adrenaline in the peripheral organs. Injection of imipramine induced a reduction of adrenaline concentration in the spleen and submaxillary gland. It is considered that adrenaline in the peripheral organs of mammals is mostly derived from the adrenal gland and that circulating adrenaline is taken up by sympathetic nerve endings in the organs. The adrenaline content of the peripheral organs increased after electric foot-shock and changed according to the time of day. The peak of the circadian rhythm appeared about 6 hours after the peak of the urinary adrenaline rhythm. These findings suggest that adrenaline in body organs plays some role in the responses of the sympathetic nervous system to stressful conditions or even to daily activities.
authors: National Institute of Industrial Health, Kawasaki, Japan.
authors: A
authors: A
authors: Sudo
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D004597:Electroshock; D004837:Epinephrine / Q000378:metabolism*; D006145:Guanethidine / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007099:Imipramine; D009638:Norepinephrine; D004837:Epinephrine; D006145:Guanethidine