The effect of tricyclic antidepressants on stress-induced heart rate changes in panic disorder patients.
Eight panic disorder patients participated in a double-blind placebo-controlled infusion study designed to induce panic-anxiety in the laboratory both before and after treatment with tricyclic antidepressants. Pre-infusion heart rates for the first infusion were significantly higher than baseline both before and after treatment. The delta increase in pre-infusion heart rates from baseline and the ratios of pre-infusion heart rates to baseline values were not significantly different between before and after treatment conditions indicating similar levels of arousal during the two pre-infusion periods, while the pre-infusion anxiety ratings after treatment were significantly lower.
Yeragani
V K
VK
Department of Psychiatry, Wayne State University, School of Medicine, Detroit, Michigan.
Rainey
J M
JM
Balon
R
R
Berchou
R
R
Lycaki
H
H
Pohl
R
R
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001008:Anxiety Disorders / Q000188:drug therapy*; D004311:Double-Blind Method; D005239:Fear / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D007773:Lactates / Q000494:pharmacology; D019344:Lactic Acid; D008297:Male; D010200:Panic / Q000187:drug effects*
D000929:Antidepressive Agents, Tricyclic; D007773:Lactates; D019344:Lactic Acid; D007545:Isoproterenol