title: Determination of the in vivo Km and Vmax of a drug with tracer studies.
abstract: A method is described for determining the in vivo Km and Vmax values for a drug, utilizing a variant of the Michaelis-Menten equation and the elimination-rate constants of tracer doses of the drug administered at two different serum concentration values. The new method is the most accurate yet devised; unlike older methods, it is dependent on assumptions that generally are true and can be validated empirically. Application of the method is demonstrated by a study of phenytoin in humans.
authors: Department of Neurology, Boston University School of Medicine, Massachusetts.
authors: T R
authors: TR
authors: Browne
authors: D
authors: D
authors: Greenblatt
authors: J E
authors: JE
authors: Evans
authors: B A
authors: BA
authors: Evans
authors: G K
authors: GK
authors: Szabo
authors: G E
authors: GE
authors: Schumacher
mesh_terms: D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics