Monitoring endoscopic treatment of superficial bladder carcinoma by postoperative urinary cytology.
Transurethral resection was the only modality of treatment in 39 patients with long-standing, recurrent, superficial bladder carcinoma. Postoperative urinary cytology was performed within 3 days of each endoscopy. Tumor recurrence was defined by the presence of a positive biopsy or visible papillary tumors on followup cystoscopic examination. Tumor recurred in 38 patients (97.4 per cent) and 1 patient (2.6 per cent) has remained free of disease 74 months following transient positive postoperative cytology. Among the 38 recurrences 15 (39.5 per cent) were positive, 3 (7.9 per cent) suspicious and 20 (52.6 per cent) negative at the postoperative cytological examination. The interval to recurrence did not differ significantly among the 3 groups. The failure of a negative postoperative cytology study to predict a durable response to treatment by transurethral resection reflects the polychronotopic nature of superficial bladder tumors in this select patient population and suggests the need for adjuvant therapy.
Badalament
R A
RA
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Gay
H
H
Cibas
E S
ES
Herr
H W
HW
Whitmore
W F
WF
Fair
W R
WR
Melamed
M R
MR
D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D010212:Papilloma / Q000473:pathology / Q000601:surgery*; D011184:Postoperative Period; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000601:surgery*; D014556:Urine / Q000166:cytology*