Decreased plasmalogen ratios in cultured skin fibroblasts from myotonic dystrophy.
It has become known that hypolipidemic agents, which can induce experimental myotonia in humans and animals, may alter the lipid metabolisms of intracellular organelles, peroxisomes. However, there has been no reported study on peroxisomal lipid metabolisms in myotonic dystrophy showing myotonia as well as experimental myotonia. We investigated one of the peroxisomal lipid metabolisms, i.e., plasmalogen metabolism in cultured skin fibroblasts from myotonic dystrophy, and found plasmalogen ratios to be significantly reduced.
Sakai
T
T
Department of Neurology, National Chikugo Hospital, Fukuoka, Japan.
Antoku
Y
Y
D002478:Cells, Cultured; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D010955:Plasmalogens / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*
D010743:Phospholipids; D010955:Plasmalogens