title: The effect of a lipid suspension on amitriptyline disposition.
abstract: A 5-h infusion of a lipid suspension or saline was given on separate occasions to four healthy volunteers taking amitriptyline. Mean plasma levels of amitriptyline plus nortriptyline were 14% higher at the end of the lipid infusion but the difference was not statistically significant. Infusion of a lipid suspension is unlikely to materially affect the severity of amitriptyline intoxication.
authors: Poisons Unit, Guy's Hospital, London, UK.
authors: N A
authors: NA
authors: Minton
authors: A G
authors: AG
authors: Goode
authors: J A
authors: JA
authors: Henry
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000097:blood / Q000493:pharmacokinetics*; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009661:Nortriptyline / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D005217:Fat Emulsions, Intravenous; D014280:Triglycerides; D000639:Amitriptyline; D009661:Nortriptyline