Effect of liquid diphenoxylate hydrochloride and atropine sulfate (Lomotil) instillations on dynamics and function of continent cecal urinary reservoirs.
We assessed the impact of twice daily instillations of 10 ml. liquid diphenoxylate hydrochloride and atropine sulfate (Lomotil) on the dynamics and function of continent urinary reservoirs constructed from intact cecum and ascending colon. Six patients were treated for 1 to 3 weeks at 3 to 8 months postoperatively. The treatments reduced the frequency of spontaneous reservoir contractions, as well as the basal and contraction pressures of the reservoirs. The reservoir capacities were increased modestly. These alterations in reservoir dynamics were accompanied by a decrease in the cramping characteristically associated with reservoir distension and increased intervals between reservoir catheterization. Two patients who had incontinence after initially successful operations regained continence during treatment. No systemic side effects were observed, although dilution of the drug may be required to prevent reservoir irritability. Diphenoxylate hydrochloride and atropine sulfate instillations may prevent acute and possibly long-term pressure-related complications of continent urinary reservoirs constructed from intact cecum and ascending colon.
Fowler
J E
JE
Division of Urology, University of Illinois College of Medicine, Chicago 60680.
Clayton
M
M
Mouli
K
K
Reagan
G
G
D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology*; D002432:Cecum / Q000187:drug effects* / Q000502:physiology / Q000637:transplantation; D004157:Diphenoxylate / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006801:Humans; D007322:Instillation, Drug; D007540:Isonipecotic Acids / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D001749:Urinary Bladder Neoplasms / Q000601:surgery; D001750:Urinary Bladder, Neurogenic / Q000601:surgery; D014547:Urinary Diversion / Q000379:methods*; D014563:Urodynamics / Q000187:drug effects
D004338:Drug Combinations; D007540:Isonipecotic Acids; C002534:atropine sulfate-diphenoxylate hydrochloride drug combination; D004157:Diphenoxylate; D001285:Atropine