Hepatitis B vaccination in healthy Chinese adults with low dose regimens.
Three hundred seronegative healthy Chinese adults were divided randomly into three groups to receive 5, 2 and 1 micrograms of Pasteur's hepatitis B vaccine on a four dose schedule. No difference between the three groups was observed in the antibody to hepatitis B surface antigen (anti-HBs) response rate (96, 92 and 94%, respectively) a month following the fourth dose of vaccination. Young vaccinees had a faster and higher anti-HBs response than older ones. There was no difference in antibody response rate by sex. This study shows a good immunogenic effect for low dose hepatitis B vaccine in Chinese adults. The use of low dose (1 microgram) hepatitis B vaccine in susceptible adults would make mass hepatitis B vaccination more economically feasible.
Lee
S D
SD
Department of Medicine, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Lo
K J
KJ
Tsai
Y T
YT
Wang
J Y
JY
Lai
K H
KH
Wu
J C
JC
Wu
T C
TC
D000328:Adult; D000367:Age Factors; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006801:Humans; D007114:Immunization; D008297:Male; D012737:Sex Factors; D013624:Taiwan; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage*
D006510:Hepatitis B Antibodies; D014761:Viral Hepatitis Vaccines