Angiotensin binding sites in bovine and human retinal blood vessels.
Blood vessels isolated from bovine and human retinas have sites that specifically bind 3H-angiotensin II (3H-Ag II) with an apparent dissociation constant (Kd) of 14 nM and a capacity of binding (Bmax) of 0.82 pmol/g. The binding sites for 3H-Ag II appear to be influenced by guanine nucleotides (GTP) and cations (Mg2+ and Na+) in a way that resembles angiotensin II receptors in other tissues. The physiologic effect of blood-borne or locally-formed angiotensin II on retinal blood flow remains to be defined.
Ferrari-Dileo
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Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, FL 33101.
Davis
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EB
Anderson
D R
DR
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D002417:Cattle; D006160:Guanosine Triphosphate / Q000494:pharmacology; D006801:Humans; D008274:Magnesium / Q000494:pharmacology; D012171:Retinal Vessels / Q000378:metabolism*; D012964:Sodium / Q000494:pharmacology
D000804:Angiotensin II; D006160:Guanosine Triphosphate; D012964:Sodium; D008274:Magnesium