Involucrin expression in keratinization disorders of the skin--a preliminary study.
We have studied the expression of involucrin in a variety of keratinization disorders, mostly of genetic origin using an avidin-biotin-peroxidase technique. In normal human epidermis 25% of the living epidermis was labelled. The diseases studied fell into two groups. Diseases with greatly increased involucrin staining including collodion baby (38%), Darier's disease (49%), Flegel's disease (56%), erythrokeratoderma variabilis (60%), epidermal naevus with epidermolytic hyperkeratosis (45%) and congenital bullous (58%) and non-bullous (44%) ichythyosiform erythroderma; and diseases with normal or slightly increased staining, including ichthyosis vulgaris (27%), X-linked ichthyosis (25%), confluent and reticulate papillomatosis (27%) and simple epidermal naevus (28%). These results demonstrate that involucrin expression is altered in some keratinization disorders and suggest that in such conditions cellular functions other than keratin metabolism are also affected.
Kanitakis
J
J
INSERUM U 209, Laboratoire de Recherche Dermatologique et Immunologie, Hôpital E. Herriot, Lyon, France.
Zambruno
G
G
Viac
J
J
Thivolet
J
J
D006801:Humans; D007642:Keratosis / Q000378:metabolism* / Q000473:pathology; D011498:Protein Precursors / Q000378:metabolism*; D012867:Skin / Q000378:metabolism / Q000473:pathology
D011498:Protein Precursors; C032253:involucrin