Metabolism of 1-methyladenosine.
1-[methyl-8-14C] Adenosine was synthesized and its metabolic fate was determined in intact rat. It was found that approximately 57% of 1-[methyl-8-14C] adenosine administered iv was excreted unchanged in the urine and 33% of the excreted radioactivity in the urine was associated with the major metabolite 1-methyl-hypoxanthine and about 4.5% was associated with 1-methylinosine. Very little adenosine or N6-methyladenosine was formed. It is concluded that 1-methyladenosine is initially deaminated by adenosine deaminase to 1-methylinosine which is then cleaved by nucleoside phosphorylase to 1-methylhypoxanthine.
Dutta
S P
SP
Department of Biophysics, Roswell Park Memorial Institute, Buffalo, New York 14263.
Chheda
G B
GB
D000241:Adenosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000652:urine; D000284:Administration, Oral; D000818:Animals; D002250:Carbon Radioisotopes; D005243:Feces / Q000032:analysis; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; C002230:1-methyladenosine; D000241:Adenosine