[Reactions of neurons in the sensory-motor cortex on different amounts of administered acetylcholine].
As a result of acetylcholine iontophoresis with different currents 3-fold increase of transmitter compared with the threshold one for reaction has been shown not to result in change of a type of reaction pattern more than in 80.3% of neurones. Such increase of action force is quite enough for the significant lengthening of the reaction excitatory components in the most of investigated neurones. After the following repeated application of smaller quantity of transmitter the number of neurones with growth of frequency of excited impulsive activity recovers as well as the level of firing frequency decrease in the course of repetitive administration of transmitter. The effect of large doses of transmitter results in aftereffect expressed by increasing probability of excitatory component reduction during the repetitive applications of acetylcholine.
Kotliar
B I
BI
Miasnikov
A A
AA
Gusev
P A
PA
D000109:Acetylcholine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005071:Evoked Potentials / Q000187:drug effects; D007478:Iontophoresis; D009044:Motor Cortex / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D013003:Somatosensory Cortex / Q000187:drug effects / Q000502:physiology*
D000109:Acetylcholine
Reaktsii neĭronov sensomotornoĭ oblasti kory na raznoe kolichestvo applitsiruemogo atsetilkholina.