title: Influence of ambroxol on lung tissue penetration of amoxicillin.
abstract: Lung amoxicillin levels were assessed in tissue obtained from 16 patients who underwent lung resection due to different pulmonary diseases. In this double-blind placebo controlled study patients were allocated to two groups in randomized order; one group received amoxicillin 1000 mg t.i.d. (n = 8) and the other amoxicillin 1000 mg + ambroxol 60 mg t.i.d. (n = 8). A trend towards higher antibiotic lung tissue levels was observed in patients who received the antibiotic together with the mucolytic agent. The ratio pulmonary tissue/serum amoxicillin levels reached a significant difference being higher in the amoxicillin plus ambroxol group than in the other one (0.411 +/- 0.04 vs 0.672 +/- 0.07; p less than 0.01), even if the amoxicillin plasma levels were lower. A possible effect of ambroxol on lung tissue penetration of amoxicillin is suggested and discussed.
authors: Instituto Roffo, University of Buenos Aires, Argentina.
authors: J
authors: J
authors: Spátola
authors: J J
authors: JJ
authors: Poderoso
authors: J C
authors: JC
authors: Wiemeyer
authors: M
authors: M
authors: Fernández
authors: R B
authors: RB
authors: Guerreiro
authors: C
authors: C
authors: Corazza
mesh_terms: D000328:Adult; D000368:Aged; D000551:Ambroxol / Q000494:pharmacology*; D000658:Amoxicillin / Q000493:pharmacokinetics*; D001964:Bromhexine / Q000031:analogs & derivatives*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis
chemical_list: D000551:Ambroxol; D000658:Amoxicillin; D001964:Bromhexine