Cimetidine and ranitidine protect against cold restraint-induced ulceration in rat by suppressing gastric acid secretion.
The effect of the H2-receptor antagonists cimetidine and ranitidine on pentagastrin-stimulated gastric acid secretion in anesthetized rats, and gastric mucosal lesion formation and gastric motility in unanesthetized cold-restrained rats was studied. Both cimetidine and ranitidine suppressed pentagastrin-stimulated gastric secretion in a dose-dependent fashion. Cold restraint-induced lesion formation was not prevented with doses of both agents that inhibited acid secretion by 75%. Doses which suppressed pentagastrin-stimulated acid secretion more than 90% significantly prevented the development of gastric mucosal lesions produced by cold restraint. Doses of both H2 blockers which demonstrated significant suppression of lesion formation had no effect on cold restraint-stimulated gastric contractility. We conclude that cimetidine and ranitidine suppress cold restraint-induced lesion formation by suppressing acid secretion and not by suppressing gastric contractility.
Garrick
T
T
Psychiatric Service, West Los Angeles VAMC, Wadsworth Division, California 90073.
Goto
Y
Y
Buack
S
S
Guth
P
P
D000818:Animals; D002927:Cimetidine / Q000627:therapeutic use*; D003080:Cold Temperature / Q000009:adverse effects*; D004353:Drug Evaluation, Preclinical; D005744:Gastric Acid / Q000378:metabolism*; D005746:Gastric Emptying / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D010418:Pentagastrin / Q000037:antagonists & inhibitors; D011899:Ranitidine / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000517:prevention & control*
D002927:Cimetidine; D011899:Ranitidine; D010418:Pentagastrin