Long-term effects of topically applied epinephrine on the blood-ocular barrier in humans.
Epinephrine (1.25%) was applied topically twice daily to both eyes of 22 patients with glaucoma or ocular hypertension. Half of these patients received topical indomethacin (0.5%) three times daily in one eye; the other half received indomethacin placebo under the same regimen. Blood-aqueous and blood-retinal barrier functions were determined by aqueous and vitreous fluorophotometry before and 1, 2, 3, and 7 months after initiation of treatment. Epinephrine-induced disruption of the blood-aqueous barrier, noted at two months, apparently remained constant until the completion of the study. At months 2, 3, and 7, indomethacin significantly inhibited this disruption. The blood-retinal barrier was unaffected. These results bear on the hypotensive mechanism of topically applied epinephrine.
Miyake
K
K
Shohzankai Medical Foundation, Miyake Eye Hospital, Nagoya, Japan.
Miyake
Y
Y
Kuratomi
R
R
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism; D001813:Blood-Retinal Barrier / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D005123:Eye / Q000098:blood supply*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011680:Pupil / Q000187:drug effects; D013997:Time Factors
D004837:Epinephrine