title: Sexual function after bilateral retroperitoneal lymph node dissection for nonseminomatous testicular cancer.
abstract: This study concerns the sexual functions of 101 patients who had undergone bilateral retroperitoneal lymph node dissection for stage I or II nonseminomatous testicular cancer between 1969 and 1982. All patients were without evidence of disease after at least 4 years of follow-up. Antegrade ejaculation was present in 12 patients, while 89 patients experienced "dry ejaculation." Urine collected after intercourse or masturbation from 75 patients with dry ejaculation showed retrograde ejaculation in 55 and lack of ejaculatory emission into the urethra in 20 patients. Regarding other sexual functions, 17 patients had a diminished sexual desire (especially those patients who had received radiotherapy), 12 experienced difficulty reaching organism, and 6 complained of erectile dysfunction. The incidence of a contralateral hydrocele developing after retroperitoneal lymph node dissection seems to correlate with ligation of the contralateral spermatic vessels and their lymphatics. A review of the literature is presented comparing the types of dissection with the incidence of sexual disorders after retroperitoneal lymph node dissection. Since preserving normal ejaculation and fertility is important, a modified or unilateral retroperitoneal lymph node dissection, when required, is advocated. In patients, with stage I disease the therapy may be limited to an orchiectomy without lymph node dissection. In patients with retroperitoneal lymph node metastases combination chemotherapy with cisplatin and tumor excision gives good results. Patients with true retrograde ejaculation can be treated with alpha-sympathomimetic drugs such as imipramine HCl, and thus be offered the chance of fatherhood by coitus.
authors: Department of Urology, University Hospital Groningen, The Netherlands.
authors: J M
authors: JM
authors: Nijman
authors: H
authors: H
authors: Schraffordt Koops
authors: J
authors: J
authors: Oldhoff
authors: J
authors: J
authors: Kremer
authors: S
authors: S
authors: Jager
mesh_terms: D000328:Adult; D000941:Antigens / Q000652:urine; D004542:Ejaculation; D006801:Humans; D007781:Lactoferrin / Q000652:urine; D008197:Lymph Node Excision / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010409:Penile Diseases / Q000209:etiology; D010410:Penile Erection; D012187:Retroperitoneal Space; D012735:Sexual Dysfunction, Physiological / Q000209:etiology*; D013094:Spermatozoa / Q000276:immunology / Q000473:pathology; D013736:Testicular Neoplasms / Q000532:radiotherapy / Q000601:surgery* / Q000652:urine; D014556:Urine / Q000166:cytology
chemical_list: D000941:Antigens; D007781:Lactoferrin