Neurovirulence effects of dengue-2 viruses on the rhesus (Macaca mulatta) brain and spinal cord.
Vaccines prepared from attenuated virus can cause symptomatic viral infection of the central nervous system. In the present study, dengue-2 parental and its live attenuated viruses were tested by intrathalamic and intraspinal injections in rhesus monkeys. The dengue-2 viruses were found to be only very weakly neurovirulent when injected directly into the brain or spinal cord of rhesus monkeys.
Angsubhakorn
S
S
Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Moe
J B
JB
Marchette
N J
NJ
Palumbo
N E
NE
Yoksan
S
S
Bhamarapravati
N
N
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D001927:Brain Diseases / Q000382:microbiology / Q000473:pathology*; D003715:Dengue / Q000473:pathology*; D003716:Dengue Virus / Q000276:immunology / Q000472:pathogenicity*; D008253:Macaca mulatta; D013118:Spinal Cord Diseases / Q000473:pathology*; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology
D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines