Measurement of lactate accumulation by in vivo proton NMR spectroscopy during global cerebral ischemia in rats.
In vivo 1H NMR spectral editing techniques were used to monitor cerebral lactate production during remotely controlled temporary forebrain ischemia in rats. The lactate/N-acetylaspartate (NAA) ratio correlated with survival after ischemia and subsequent reperfusion. The lactate/NAA ratio that predicted death after ischemia in rats was estimated to be approximately 1.3.
Richards
T L
TL
Department of Pharmaceutical Chemistry, University of California School of Medicine, San Francisco 94143.
Keniry
M A
MA
Weinstein
P R
PR
Pereira
B M
BM
Andrews
B T
BT
Murphy
E J
EJ
James
T L
TL
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D007773:Lactates / Q000096:biosynthesis*; D009682:Magnetic Resonance Spectroscopy; D051381:Rats
D007773:Lactates