title: [Changes in the behavioral and biochemical effects of cerulein, an analog of cholecystokinin octapeptide, after prolonged administration of haloperidol].
abstract: In experiments on male mice and rats, long-term haloperidol administration (0.25 mg/kg twice a day during 15 days) significantly changed behavioural effects of caerulein, an agonist of CCK-8 receptors. As a rule, the effects of caerulein were reduced or inverted; only long-term antagonism with amphetamine motor excitation in rats increased after the cessation of haloperidol administration. The decrease or inversion of caerulein's effects was connected with reduction of high-affinity dopamine2- and low-affinity CCK-8 receptors' density, reflecting the inhibition of some interneurons' activity in subcortical forebrain structures after haloperidol treatment. A more pronounced inhibition of dopamine's release by caerulein was the reason for the increased antiamphetamine action after long-term haloperidol treatment. It seems possible that both above mechanisms are involved in the antipsychotic action of haloperidol.
authors: E E
authors: EE
authors: Vasar
authors: L Kh
authors: LKh
authors: Allikmets
authors: A Kh
authors: AKh
authors: Soosaar
authors: A E
authors: AE
authors: Lang
mesh_terms: D000818:Animals; D000927:Anticonvulsants; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D002108:Ceruletide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011949:Receptors, Cholecystokinin / Q000187:drug effects*; D012844:Sincalide / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D011949:Receptors, Cholecystokinin; D002108:Ceruletide; D006220:Haloperidol; D012844:Sincalide
vernacular_title: Izmenenie povedencheskikh i biokhimicheskikh éffektov tseruleina, analoga oktapeptida kholetsistokinina, posle dlitel'nogo vvedeniia galoperidola.