The influence of propranolol and glucagon on the pharmacokinetics of antipyrine and sodium salicylate.
Propranolol (1) decreases hepatic blood flow and glucagon (2) exerts an opposite effect on hepatic circulation. The effects of these drugs on the pharmacokinetics of phenazone (3; antipyrine)-a compound with low coefficient of hepatic extraction, and sodium salicylate (4) that is highly extracted by liver, were studied on rabbits. It was shown that changes in the pharmacokinetics of 3 and 4 in the presence of 1 or 2, seemed to be interactions between these drugs in the haemodynamic phase.
Orszulak-Michalak
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D
Department of Pharmacodynamics, Medical Academy, Lodź, Poland.
Kaszubski
P
P
D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics*; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D006207:Half-Life; D008102:Liver Circulation / Q000187:drug effects; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits; D012459:Salicylates / Q000493:pharmacokinetics*; D020156:Salicylic Acid
D012459:Salicylates; D005934:Glucagon; D011433:Propranolol; D020156:Salicylic Acid; D000983:Antipyrine