Amnesic action of FMRFamide in rats.
The effects of FMRFamide on passive avoidance behaviour and electroshock-induced amnesia following intracerebroventricular administration were studied in rats. FMRFamide given immediately after the learning trial, or 20 min before the retention trial, attenuated the avoidance response, thereby impairing the consolidation and retrieval processes. Electroshock induced amnesia when applied immediately after the learning trial. Treatment with FMRFamide facilitated the amnesia of the passive avoidance response. The results indicate that FMRFamide peptide belongs in the class of neuropeptide which are amnesic.
Telegdy
G
G
Inst. Pathophysiology, University Medical School Szeged, Hungary.
Bollók
I
I
D000647:Amnesia / Q000139:chemically induced*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004597:Electroshock; D019835:FMRFamide; D007276:Injections, Intraventricular; D008297:Male; D009479:Neuropeptides / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects
D009479:Neuropeptides; D019835:FMRFamide