Clinical significance of antibodies against peripheral nerve tissue in inflammatory polyneuropathy.
With the use of a mixed hemagglutination test (MHT), circulating antibodies against human peripheral nerve tissue (PNT) were found in 22 of 38 patients with Guillain-Barré syndrome (GBS) or chronic relapsing demyelinating inflammatory polyneuropathy (CR-DIP). The antibodies were found in only 1 of 34 patients with polyneuropathy of other origin, and in 3 of 32 patients without polyneuropathy. The presence of antibodies was related to response to intravenous gamma globulin treatment in CR-DIP patients. Antibodies against PNT may be pathogenic.
van Doorn
P A
PA
Department of Neurology, Academic Hospital Rotterdam-Dijkzigt, The Netherlands.
Brand
A
A
Vermeulen
M
M
D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology*; D003711:Demyelinating Diseases / Q000276:immunology; D006386:Hemagglutination Tests; D006801:Humans; D009422:Nervous System Diseases / Q000276:immunology*; D010525:Peripheral Nerves / Q000276:immunology*; D011129:Polyradiculoneuropathy / Q000276:immunology*; D012584:Sciatic Nerve / Q000276:immunology
D000936:Antigen-Antibody Complex; D001323:Autoantibodies