Simulation analysis of conduction of excitation in the atrioventricular node.
The excitation conduction in the atrioventricular node was simulated based on the spatially discrete model of the heart proposed in an earlier paper (Kawato et al., 1986). We constructed a model system composed of the atrium, the atrioventricular node and the Purkinje fiber. Coupling coefficients between these tissues were quantitatively estimated from experimental data on size and membrane capacitance of the three kinds of cardiac cells. We found the following three important features in the simulated excitation conduction along the atrioventricular node. First, shape of action potential was found to be different at different locations of the atrioventricular node although the membrane properties were assumed uniform through the atrioventricular node. Our analysis suggests that the difference in the action potential waveforms observed by Paes de Carvalho & De Almedia (1960) can be ascribed to the electrical influences of the atrium and the His bundle on the atrioventricular node. Second, when the excitation wavefront invaded the atrioventricular node from the atrium, a step was observed in the depolarization phase of the action potential at the atrioventricular node neighboring with the atrium. Janse found a similar step in the real experiment (1969). It is revealed that this step is caused by termination of the junctional current which flows from the atrium to the atrioventricular node. Finally, we found that the conduction velocity measured near the boundary between the atrium and the atrioventricular node was lower than that in the middle part of the atrioventricular node, which is in accordance with the experimental observation by Scher et al. (1959).
Urushibara
S
S
Department of Biophysical Engineering, Faculty of Engineering Science, Osaka University, Japan.
Kawato
M
M
Nakazawa
K
K
Suzuki
R
R
D000200:Action Potentials; D016275:Atrial Function; D001283:Atrioventricular Node / Q000166:cytology / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology; D004553:Electric Conductivity; D006329:Heart Conduction System / Q000502:physiology*; D008955:Models, Cardiovascular; D011690:Purkinje Fibers / Q000166:cytology / Q000502:physiology