The structure of an oligo(dA).oligo(dT) tract and its biological implications.
Poly(dA).poly(dT) has unusual properties in that it cannot associate into nucleosomes and short, phased runs of it cause DNA bending. The crystal structure of a B-type DNA dodecamer containing a homopolymeric run of six A.T base pairs shows that this region possesses special structural features, including a system of bifurcated hydrogen bonds, which explains some of the properties of this simple homopolymer.
Nelson
H C
HC
Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.
Finch
J T
JT
Luisi
B F
BF
Klug
A
A
D001482:Base Composition; D001483:Base Sequence; D003460:Crystallization; D004247:DNA; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides; D011067:Poly dA-dT; D011089:Polydeoxyribonucleotides; D014961:X-Ray Diffraction
D009838:Oligodeoxyribonucleotides; D011089:Polydeoxyribonucleotides; C027903:oligo (dT); C030570:oligodeoxyadenylic acid; D011067:Poly dA-dT; D004247:DNA