Lung carcinogenesis by N-nitrosobis(2-hydroxypropyl)amine-related compounds and their formation in rats.
Lung carcinogenesis by a single intraperitoneal injection of N-nitrosobis(2-hydroxypropyl)amine (NDHPA) and related compounds was studied in male Wistar rats. NDHPA, N-nitrosomethyl(2-hydroxypropyl)amine (NMHPA), N-nitrosobis(2-oxopropyl)amine (NDOPA), N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine (NHPOPA) and N-nitroso-2,6-dimethylmorpholine (NDMMOR) induced high incidences of lung neoplasms in rats. The formation of NDHPA, NDMMOR and NMHPA in the stomach of rats treated with precursor amines and sodium nitrite was detected by high-performance liquid chromatography (HPLC).
Konishi
Y
Y
Department of Oncological Pathology, Nara Medical College, Japan.
Yokose
Y
Y
Mori
Y
Y
Yamazaki
H
H
Yamamoto
K
K
Nakajima
A
A
Denda
A
A
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D009602:Nitrosamines; D051381:Rats; D011919:Rats, Inbred Strains
D009602:Nitrosamines; C012457:diisopropanolnitrosamine