The penetration of antibiotics into the normal intervertebral disc.
The role of antibiotics in the treatment of disc-space infection is controversial. This study assessed the tissue penetration of flucloxacillin and cephradine into the normal intervertebral disc after intravenous administration of a bolus dose of antibiotic. Twenty-five discs were removed from 12 adolescent patients having anterior spinal surgery to correct scoliosis; antibiotic had been administered between 30 minutes and four hours before operation. Despite high blood levels, no antibiotic could be detected by bioassay or by high-pressure liquid chromatography (h.p.l.c.) in any of the specimens from the nucleus pulposus or the annulus fibrosus.
Gibson
M J
MJ
Spinal Research Unit, Harlow Wood Orthopaedic Hospital, Nottingham, England.
Karpinski
M R
MR
Slack
R C
RC
Cowlishaw
W A
WA
Webb
J K
JK
D000042:Absorption; D000293:Adolescent; D000328:Adult; D001681:Biological Assay; D002511:Cephalosporins / Q000493:pharmacokinetics*; D002515:Cephradine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002648:Child; D002851:Chromatography, High Pressure Liquid; D003023:Cloxacillin / Q000031:analogs & derivatives*; D005260:Female; D005436:Floxacillin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007275:Injections, Intravenous; D007403:Intervertebral Disc / Q000378:metabolism* / Q000601:surgery; D008297:Male; D011292:Premedication; D011446:Prospective Studies; D012600:Scoliosis / Q000378:metabolism / Q000601:surgery; D013131:Spine / Q000601:surgery; D013211:Staphylococcus aureus / Q000187:drug effects
D002511:Cephalosporins; D005436:Floxacillin; D002515:Cephradine; D003023:Cloxacillin