title: Delayed spontaneous alternation in Purkinje cell degeneration mutant mice.
abstract: Purkinje cell degeneration (pcd) mutant mice lose cerebellar Purkinje cells. It was found that pcd mice, contrary to normal mice, did not alternate spontaneously at any of 3 inter-trial intervals (15 s, 3 or 6 min). Deficits in spontaneous alternation are typical of animals with brain damage in areas important in spatial learning. Results are discussed in terms of a role for the cerebellum in spatially mediated behavior and behavioral inhibition.
authors: Hôtel-Dieu Hospital, Neurology Service, Montreal, Que., Canada.
authors: R
authors: R
authors: Lalonde
authors: M
authors: M
authors: Manseau
authors: M I
authors: MI
authors: Botez
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008818:Mice, Neurologic Mutants / Q000502:physiology*; D009410:Nerve Degeneration; D011689:Purkinje Cells / Q000502:physiology*; D013037:Spatial Behavior / Q000502:physiology*