title: Identification of the receptor for toxin II alpha from scorpion Leirus quinquestriatus in isolated lobster and squid nerve membranes.
abstract: 1. Isolated membranes from lobster and squid nerves were labeled with Leirus quinquestriatus toxin II alpha. 2. Dinitrofluorophenylazide 125I-ScTx derivative was synthesized and covalently bound to the membranes. 3. It was found that the membranes of these nonmyelinated nerves present a single polypeptide located at approximately 220-230 Kd range labeled by the ScTx. 4. Rat brain membrane used for comparison presents two polypeptidic zones at 220 and 50 Kd labeled by the toxin.
authors: Instituto Venezolano de Investigaciones Científicas, Centro de Biofísica y Bioquímica, Caracas.
authors: D
authors: D
authors: Delgado
authors: F V
authors: FV
authors: Barnola
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D049832:Decapodiformes; D066298:In Vitro Techniques; D008121:Nephropidae; D009474:Neurons / Q000378:metabolism*; D009498:Neurotoxins / Q000378:metabolism; D051381:Rats; D011950:Receptors, Cholinergic / Q000302:isolation & purification / Q000378:metabolism*; D012604:Scorpion Venoms / Q000378:metabolism*; D015222:Sodium Channels; D013045:Species Specificity
chemical_list: D009498:Neurotoxins; D011950:Receptors, Cholinergic; D012604:Scorpion Venoms; D015222:Sodium Channels; C053971:neurotoxin IIalpha (Leirus); C029574:scorpion toxin receptor