Thermal energy analysis of N-nitroso compounds, including ureas, urethanes and guanidines.
Simple, selective, sensitive analytical methods have been developed for a number of N-nitroso compounds (NOC) which are applicable to environmental and biological matrices and have been used to quantify nitrosourea anticancer drugs in human plasma. These new chromatographic detection windows can be used to screen suspect matrices for NOC.
Fine
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DH
Thermedics Inc., Woburn, MA 01888.
Goff
E U
EU
Johnson
R A
RA
Rounbehler
D P
DP
D000970:Antineoplastic Agents / Q000032:analysis; D002845:Chromatography / Q000379:methods; D006207:Half-Life; D006358:Hot Temperature; D006801:Humans; D009603:Nitroso Compounds / Q000032:analysis*; D009604:Nitrosoguanidines / Q000032:analysis; D014508:Urea; D014520:Urethane
D000970:Antineoplastic Agents; D009603:Nitroso Compounds; D009604:Nitrosoguanidines; D014520:Urethane; D014508:Urea