The value of HbA1 and fructosamine in predicting impaired glucose tolerance--an alternative to OGTT to detect diabetes mellitus or gestational diabetes.
Glycosylated haemoglobin and glycosylated serum protein concentrations (fructosamine) have been monitored in patients suspected of diabetes mellitus (n = 183), in pregnant women suspected of gestational diabetes (n = 250) and in control groups (n = 184). The response to the standard 75 g oral glucose tolerance test was used to confirm or reject the diagnosis, using different criteria for detection of diabetes mellitus compared to detection of gestational diabetes. A slightly higher sensitivity was observed for fructosamine compared to glycosylated haemoglobin to detect impaired glucose tolerance (52 vs 44%) or gestational diabetes (17% vs 8%). For detection of diabetic oral glucose tolerance no difference was observed between glycosylated haemoglobin and fructosamine; sensitivity for both parameters was 67%. The results suggest that fructosamine is slightly more sensitive in detecting borderline-abnormal glucose tolerance, whereas no differences are observed for detection of clearly abnormal oral glucose tolerance tests.
Salemans
T H
TH
Department of Chemical Pathology, De Wever Hospital, Heerlen, Netherlands.
van Dieijen-Visser
M P
MP
Brombacher
P J
PJ
D000284:Administration, Oral; D003920:Diabetes Mellitus / Q000175:diagnosis*; D005260:Female; D019270:Fructosamine; D005951:Glucose Tolerance Test / Q000379:methods*; D006442:Glycated Hemoglobin / Q000032:analysis*; D006595:Hexosamines / Q000097:blood*; D006801:Humans; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000175:diagnosis; D012372:ROC Curve
D019270:Fructosamine; D006442:Glycated Hemoglobin; D006595:Hexosamines