Bone repair inhibited by indomethacin. Effects on bone metabolism and strength of rabbit osteotomies.
We measured mineral content, maximum bending strength, and regional blood flow after tibial osteotomy fixed with a small metal plate in 38 rabbits. Half of the animals were treated with indomethacin (10 mg/kg/day) while the other half served as controls. After 2 and 6 weeks, the bone mineral content and maximum bending strength were lower in the indomethacin group when compared with the controls. Compared with the controls, the blood flow at the osteotomy site was decreased after 2 weeks and increased after 6 weeks in the indomethacin-treated animals. Inhibition of blood flow increase by indomethacin medication in the early period following osteotomy, as well as retarded bone healing, are probably caused by inhibition of the inflammatory reaction.
Keller
J
J
Institute of Experimental Clinical Research, University of Aarhus, Denmark.
Bünger
C
C
Andreassen
T T
TT
Bak
B
B
Lucht
U
U
D000818:Animals; D007213:Indomethacin / Q000494:pharmacology*; D008903:Minerals / Q000378:metabolism; D010027:Osteotomy; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D013718:Tensile Strength / Q000187:drug effects; D013977:Tibia / Q000098:blood supply / Q000378:metabolism* / Q000601:surgery
D008903:Minerals; D007213:Indomethacin