title: Antihypertensive and antithrombotic activities of 6-(substituted phenyl)-5-hydroxymethyl-4,5-dihydro-3(2H)pyridazinones.
abstract: The synthesis of a series of 6-(4R-phenyl)-5-hydroxymethyl-4,5-dihydro-3(2H)pyridazinones is reported. The compounds were evaluated for their oral antihypertensive activity in rats and some of them [(V b), R = NH2] and [(V c), R = NHCOCH3] were found to induce a high decrease in systolic blood pressure. Moreover all the compounds displayed an antithrombotic activity comparable to, or greater than, that of ASA.
authors: Istituto Chimico Farmaceutico e Tossicologico Università di Milano, Italy.
authors: D
authors: D
authors: Barlocco
authors: A
authors: A
authors: Martini
authors: G A
authors: GA
authors: Pinna
authors: M M
authors: MM
authors: Curzu
authors: F
authors: F
authors: Sala
authors: M
authors: M
authors: Germini
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004078:Dihydralazine / Q000494:pharmacology; D005343:Fibrinolytic Agents / Q000138:chemical synthesis*; D008297:Male; D051379:Mice; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D005343:Fibrinolytic Agents; D011724:Pyridazines; D004078:Dihydralazine