Anti-inflammatory studies on Polygonum glabrum.
Anti-inflammatory studies were conducted on a hot water decoction and on an ethanol extract of the stems of Polygonum glabrum. Effective anti-inflammatory activity was demonstrated against acute carrageenan-induced paw oedema, exudate and granuloma formation in the granuloma pouch test, acute and delayed reactions in formaldehyde arthritis, and acute primary and delayed secondary reactions in adjuvant-induced polyarthritis in albino rats. The acute toxicity in albino mice and 1-month studies on subacute toxicity in rats suggested a good margin of safety. The extract was more effective parenterally than by oral administration.
Singh
B
B
Department of Pharmacology, Banaras Hindu University, Varanasi, India.
Pandey
V B
VB
Joshi
V K
VK
Gambhir
S S
SS
D000818:Animals; D000893:Anti-Inflammatory Agents; D001168:Arthritis / Q000139:chemically induced / Q000517:prevention & control; D001169:Arthritis, Experimental / Q000517:prevention & control; D004487:Edema / Q000517:prevention & control; D000431:Ethanol; D005260:Female; D005557:Formaldehyde; D006099:Granuloma / Q000188:drug therapy; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D005557:Formaldehyde; D000431:Ethanol