The involvement of neuropeptide Y in the antimuricide action of noradrenaline injected into the medial amygdala of olfactory bulbectomized rats.
The present study was designed to clarify the functional role of neuropeptide Y (NPY) in the regulation of muricide induced by olfactory bulbectomy (OB) in relation to that of noradrenaline (NA) in the medial amygdala (AME). NA injected into AME inhibited muricide dose-dependently in OB rats. NPY at doses of 5 and 10 micrograms/microliter injected alone into AME failed to suppress muricide. When NPY 10 micrograms was injected into AME in combination with the maximal non-effective dose of NA, which was determined in each rat, muricide was suppressed in 80% of OB rats. The present study has provided the first evidence suggesting that NPY may be involved in the regulation of OB-induced muricide.
Kataoka
Y
Y
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Sakurai
Y
Y
Mine
K
K
Yamashita
K
K
Fujiwara
M
M
Niwa
M
M
Ueki
S
S
D000374:Aggression / Q000187:drug effects*; D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology / Q000502:physiology*; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D009830:Olfactory Bulb / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D009478:Neuropeptide Y; D009638:Norepinephrine