title: Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis.
abstract: Twelve patients with active rheumatoid arthritis supplemented their usual diet with 20 gm of Max-EPA fish oil, daily, for 6 weeks. Following this supplementation, the ratio of arachidonic acid to eicosapentaenoic acid in the patients' neutrophil cellular lipids decreased from 81:1 to 2.7:1, and the mean generation of leukotriene B4 (with calcium ionophore stimulation) significantly declined by 33%. The mean neutrophil chemotaxis to both leukotriene B4 and FMLP significantly increased toward the normal range at week 6. The generation of 5-lipoxygenase products by calcium ionophore-stimulated monocytes was not significantly suppressed, but a significant decline (37%) in platelet-activating factor generation was noted at week 6. The modulation of these measures of leukocyte inflammatory potential suggests that fish oil supplementation may have an antiinflammatory effect.
authors: Department of Medicine, Harvard Medical School, Boston, Massachusetts.
authors: R I
authors: RI
authors: Sperling
authors: M
authors: M
authors: Weinblatt
authors: J L
authors: JL
authors: Robin
authors: J
authors: J
authors: Ravalese
authors: R L
authors: RL
authors: Hoover
authors: F
authors: F
authors: House
authors: J S
authors: JS
authors: Coblyn
authors: P A
authors: PA
authors: Fraser
authors: B W
authors: BW
authors: Spur
authors: D R
authors: DR
authors: Robinson
mesh_terms: D000328:Adult; D001094:Arachidonate 5-Lipoxygenase / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000178:diet therapy*; D002634:Chemotaxis, Leukocyte; D002908:Chronic Disease; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use*; D005527:Food, Fortified; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D010972:Platelet Activating Factor / Q000032:analysis; D013997:Time Factors
chemical_list: D005395:Fish Oils; D008055:Lipids; D010972:Platelet Activating Factor; D001094:Arachidonate 5-Lipoxygenase