Buspirone blocks motion sickness and xylazine-induced emesis in the cat.
Cats were tested for motion sickness following s.c. pretreatment with four doses of buspirone. Buspirone blocked motion sickness with an ED50 of 0.46 mg . kg-1 base. Buspirone pretreatment (4.0 mg . kg-1 base) also significantly blocked vomiting in cats later injected with 0.66 mg . kg-1 (base) s.c. of the emetic drug xylazine. The results are interpreted as showing that buspirone is acting at the vomiting center, the point of convergence for the separate mechanisms subserving chemically-induced emesis and motion sickness.
Lucot
J B
JB
Department of Pharmacology and Toxicology, Wright State University, Dayton, Ohio 45435.
Crampton
G H
GH
D000818:Animals; D002065:Buspirone / Q000627:therapeutic use*; D002415:Cats; D005260:Female; D009041:Motion Sickness / Q000517:prevention & control*; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*; D014991:Xylazine / Q000037:antagonists & inhibitors
D014991:Xylazine; D002065:Buspirone