title: [Metabolic pool of purine and pyrimidine derivatives in the palatine tonsil of patients with chronic tonsillitis].
abstract: Tonsils from 10 patients (18-40 years old), with chronic tonsillitis were studied by means of histological methods as well as by high pressure liquid chromatography. In 5 patients with decompensated forms of the disease, accompanied by heart impairments during 1-3 years, only slight alterations in epithelial and follicular parts of tonsils were observed, while pronounced destruction of tonsil cells was detected in other 5 patients suffering from repeated anginas. The following purine and pyrimidine derivatives were identified in faucial tonsil tissue of all the patients with chronic tonsillitis studied: adenine, guanine, adenosine, guanosine, inosine and uridine. Distinct increase in content of these derivatives as well as occurrence of xanthine and uric acid (non-identified in the first group of patients with chronic tonsillitis) was noted in the patients with maximal destruction of faucial tonsil cells.
authors: R T
authors: RT
authors: Toguzov
authors: Iu V
authors: IuV
authors: Tikhonov
authors: A M
authors: AM
authors: Pimenov
authors: L I
authors: LI
authors: Markusheva
mesh_terms: D000293:Adolescent; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D014066:Palatine Tonsil / Q000378:metabolism*; D011687:Purines / Q000378:metabolism*; D011743:Pyrimidines / Q000378:metabolism*; D014069:Tonsillitis / Q000378:metabolism*
chemical_list: D011687:Purines; D011743:Pyrimidines
vernacular_title: Metabolicheskiĭ fond purinovykh i pirimidinovykh proizvodnykh tkani nebnykh mindalin u bol'nykh khronicheskim tonzillitom.