Routine synthesis of carbon-11-carboxyl-labeled L-dopa.
Carbon-11-carboxyl-labeled L-dopa has been synthesized by the modified Bucherer-Strecker method. The reaction mixture was first purified by chiral HPLC followed by deprotection using hydriodic acid. The entire procedure was performed in a remotely operated system which gave the product in 28% radiochemical yield (decay corrected) in an overall synthesis time of 55-60 min.
Adam
M J
MJ
UBC/TRIUMF Program on Positron Emission Tomography, Vancouver, Canada.
Grierson
J R
JR
Ruth
T J
TJ
Pedersen
K
K
Pate
B D
BD
D002250:Carbon Radioisotopes; D007553:Isotope Labeling / Q000379:methods*; D007980:Levodopa
D002250:Carbon Radioisotopes; D007980:Levodopa