title: Interdigestive motility pattern in subjects with duodenogastric bile reflux.
abstract: The role of antroduodenal motility in the pathogenesis of duodenogastric biliary reflux is widely accepted, but few and conflicting data are available on the possible motor abnormalities related to this phenomenon in the fed and in the fasting state. In an attempt to define the motility pattern of the antroduodenal region associated with bile reflux in the fasting state, 20 subjects with proven duodenogastric reflux and without disorders of the upper gastrointestinal tract have been studied, and the results have been compared with those observed in 6 control subjects without evidence of reflux. The interdigestive motility complex (IDMC) has been evaluated (mean duration of IDMC and frequency and site of onset of migrating motor complexes). In subjects with duodenogastric reflux a significant increase (p less than 0.01) in the mean duration of IDMCs (179 +/- 22.19 min) was observed, in comparison with controls (108.5 +/- 37 min). A considerable reduction in the frequency of migrating motor complexes (MMC) was also observed, while no differences in the site of onset and the propagation of MMCs and in the percentage of time recorded occupied by the single phases of IDMC were found. This evidence suggests a strict relationship between duodenogastric reflux and the occurrence of phase III of IDMC and supports the hypothesis that the IDMC abnormalities are the cause and not the consequence of biliary reflux. The reduced incidence of MMC may also account for the high incidence of chronic gastritis due to prolonged contact in the fasting state between the gastric mucosa and the duodenal content.
authors: Gastroenterology Unit, University of Milan, Italy.
authors: P A
authors: PA
authors: Testoni
authors: L
authors: L
authors: Fanti
authors: S
authors: S
authors: Passaretti
authors: E
authors: E
authors: Masci
authors: M
authors: M
authors: Guslandi
authors: A
authors: A
authors: Tittobello
mesh_terms: D000328:Adult; D001655:Bile Reflux / Q000503:physiopathology*; D001660:Biliary Tract Diseases / Q000503:physiopathology*; D004386:Duodenum / Q000503:physiopathology*; D004943:Esophagogastric Junction / Q000294:innervation; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D008875:Middle Aged; D011706:Pyloric Antrum / Q000503:physiopathology*