[Comparative study of the RNA-polymerase activity of non-pathogenic and pathogenic influenza viruses A and B].
Activity of RNA polymerase was studied in original non-pathogenic for mice viruses of influenza A and B (A/seal/Massachusetts 1/80, A/USSR 05/81, A/Philippines 2/82 and B/Singapore 227/79) and of their pathogenic derivatives. All the non-pathogenic viruses studied exhibited the low rate of transcriptase activity. Pathogenic derivatives of these strains exhibited higher activity of RNA polymerase, which was 1.5-3-fold higher as compared with the original strain. During passage of influenza viruses A and B in mice organism selection of the population appears to occur, which had the highest transcriptase activity.
Pravdina
N F
NF
Podcherniaeva
R Ia
RIa
Skovorodka
V V
VV
Galegov
G A
GA
Zhdanov
V M
VM
D000818:Animals; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D009980:Influenza A virus / Q000201:enzymology* / Q000472:pathogenicity; D009981:Influenza B virus / Q000201:enzymology* / Q000472:pathogenicity; D007700:Kinetics; D051379:Mice; D014771:Virion / Q000201:enzymology
D012321:DNA-Directed RNA Polymerases
Sravnitel'noe issledovanie aktivnosti RNK-polimerazy u nepatogennykh i patogennykh virusov grippa A i B.