title: Effect of dimethylsulfoxide concentration on the permeability of neonatal rat stratum corneum to alkanols.
abstract: The effect of dimethylsulfoxide (DMSO) concentration on the permeability of neonatal rat stratum corneum to 14C labeled propan-1-ol and hexan-1-ol was studied in vitro. The permeability coefficients were determined from a range of DMSO-water systems. After soaking in water overnight, the same stratum corneum was used with water as both delivery and recipient phases for the alkanols. Concentrations below 70% DMSO reduced the penetration rate as a result of the solvent effect of DMSO and the formation of a DMSO-alkanol complex. Above 70% DMSO permeability increased, with a permeability coefficient greater than that from water being achieved at concentrations in excess of 80% DMSO. The second run, with water as delivery phase, showed that the effect was reversible below 70% DMSO, but that at higher concentrations DMSO had produced an irreversible change in the permeability of stratum corneum. We hypothesize a hydrogen bond-mediated mechanism for the increased permeability.
authors: School of Pharmacy, Robert Gordon's Institute of Technology, Aberdeen, Scotland, U.K.
authors: S M
authors: SM
authors: Al-Saidan
authors: A B
authors: AB
authors: Selkirk
authors: A J
authors: AJ
authors: Winfield
mesh_terms: D000433:1-Propanol / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D004058:Diffusion; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004817:Epidermis / Q000187:drug effects*; D000441:Hexanols / Q000378:metabolism*; D006860:Hydrogen Bonding; D066298:In Vitro Techniques; D010539:Permeability; D051381:Rats; D014867:Water
chemical_list: D000441:Hexanols; D014867:Water; D000433:1-Propanol; D004121:Dimethyl Sulfoxide