Alternative splicing increases the diversity of the human protein kinase C family.
Isolation of two protein kinase C (PKC) cDNA clones containing divergent carboxy-terminal sequences suggested a common genetic origin for these cDNAs. Partial characterization of the hPKC beta chromosomal gene provided direct evidence for the existence of two adjacent carboxy-terminal exons (beta 1 and beta 2) that are alternatively spliced to generate two types of hPKC beta sequences. PKC beta 1 and beta 2 mRNAs are expressed in a selective manner in both human hematopoietic cells and bovine brain tissues.
Coussens
L
L
Department of Developmental Biology, Genentech, Inc., South San Francisco, CA 94080.
Rhee
L
L
Parker
P J
PJ
Ullrich
A
A
D000595:Amino Acid Sequence; D001483:Base Sequence; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D011493:Protein Kinase C / Q000235:genetics*; D012326:RNA Splicing; D014018:Tissue Distribution
D011493:Protein Kinase C