Increased catabolism of muscle proteins as a manifestation of radiation myopathy.
Exposure of the hindquarter of the rat to 1000 rad of gamma-radiation caused a significant increase in the release of glutamine and alanine into the perfusion fluid at 4 h post-irradiation. The extent of the release of glutamine exceeded that of alanine. Furthermore, the exposure to gamma-radiation brought about a significant lowering of the intra-/extracellular concentration gradient with respect to glutamine and alanine.
Altman
K I
KI
Institut für Medizin, Kernforschungsanlage GmbH, Jülich, Federal Republic of Germany.
Schwenen
M
M
D000227:Adenine Nucleotides / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D005720:Gamma Rays; D005947:Glucose / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006614:Hindlimb; D007773:Lactates / Q000378:metabolism; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism*; D009132:Muscles / Q000528:radiation effects*; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats
D000227:Adenine Nucleotides; D000596:Amino Acids; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D009124:Muscle Proteins; D010725:Phosphocreatine; D006003:Glycogen; D005947:Glucose; D005990:Glycerol