title: The electrophysiological effects of nicotine in the rat cerebellum: evidence for direct postsynaptic actions.
abstract: The agonistic actions of nicotine in the cerebellum were dependent on the type of cerebellar neuron studied. Purkinje cells were inhibited and cerebellar interneurons were excited by pressure-ejected nicotine. The simultaneous iontophoresis of Mg2+ failed to block nicotine agonistic actions on either cell type. Since Mg2+ reduces presynaptic release of neurotransmitters, our findings suggest that the pharmacological actions of nicotine on cerebellar neurons are due to direct postsynaptic mechanisms.
authors: University of Colorado Health Sciences Center, Department of Pharmacology, Denver 80262.
authors: R
authors: R
authors: de la Garza
authors: T J
authors: TJ
authors: McGuire
authors: R
authors: R
authors: Freedman
authors: B J
authors: BJ
authors: Hoffer
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002531:Cerebellum / Q000187:drug effects / Q000502:physiology*; D007395:Interneurons / Q000502:physiology; D008274:Magnesium / Q000494:pharmacology / Q000502:physiology; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D011689:Purkinje Cells / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000502:physiology
chemical_list: D011978:Receptors, Nicotinic; D009538:Nicotine; D008274:Magnesium