Effect of natural beta-interferon on cell proliferation and steroid receptor level in human breast cancer cells.
The effect of natural beta-interferon (beta-IFN) on cell proliferation and steroid receptor level was investigated in CG-5 human breast cancer cell line. beta-interferon determines an appreciable diminution of cell growth, at concentrations ranging from 100 to 1000 IU/ml, which is enhanced when serum content of the culture medium is lowered. Low concentrations of beta-IFN (10-100 IU/ml) produce, after a 5-day treatment, an increase in estrogen receptors (ER) and progesterone receptors (PR). No variation of ER and PR levels is observed when beta-IFN is added directly to the cell homogenate before the assay. Our data suggest that beta-IFN could affect hormone sensitivity through a modification of ER and PR in neoplastic mammary cells.
Sica
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Istituto di Istologia ed Embriologia Generale, Università Cattolica del S. Cuore, Rome, Italy.
Natoli
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V
Stella
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Del Bianco
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D001943:Breast Neoplasms / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D009376:Neoplasms, Hormone-Dependent / Q000473:pathology*; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D014407:Tumor Cells, Cultured / Q000032:analysis / Q000187:drug effects*
D007370:Interferon Type I; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone