S1-receptor participation in serotonin-induced pulmonary edema in the dog.
A canine lung-perfusion preparation was used to evaluate the role of serotonin receptor subtype in the development of serotonin-induced pulmonary edema. Ketanserin, an S2-receptor antagonist, blocked an increase in pulmonary arterial pressure caused by serotonin, but not the development of pulmonary edema. Methysergide, an S1- and S2-receptor antagonist, prevented the increase in pulmonary arterial pressure and edema formation caused by serotonin. These results suggest that the S1-receptor may participate in the development of pulmonary edema.
Kamiya
I
I
Department of Pharmacology, Nagoya University School of Medicine, Japan.
Sumita
T
T
Ishikawa
N
N
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001834:Body Water / Q000378:metabolism; D002199:Capillary Permeability / Q000187:drug effects; D004285:Dogs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007650:Ketanserin / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008784:Methysergide / Q000494:pharmacology; D011654:Pulmonary Edema / Q000139:chemically induced / Q000503:physiopathology*; D011985:Receptors, Serotonin / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology*
D011985:Receptors, Serotonin; D012701:Serotonin; D006632:Histamine; D007650:Ketanserin; D008784:Methysergide