Embryotoxic effects of sodium metavanadate administered to rats during organogenesis.
Pregnant Sprague-Dawley rats were given orally a daily dose of 0, 5, 10 or 20 mg NaVO3/kg from the sixth through the fourteenth day of pregnancy. Fetal examinations were performed on day 20 of gestation. Sodium metavanadate was neither embryolethal nor teratogenic in rats when administered orally at 20 mg/kg/day or lower. Nevertheless, this dose was embryotoxic.
Paternain
J L
JL
Departamento de Bioquímica, Facultad de Medicina, Universidad de Barcelona, Reus/Tarragona, Spain.
Domingo
J L
JL
Llobet
J M
JM
Corbella
J
J
D000818:Animals; D020964:Embryo Loss / Q000139:chemically induced; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D008297:Male; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects; D013723:Teratogens; D014638:Vanadates / Q000633:toxicity*
D013723:Teratogens; D014638:Vanadates