title: Progressive multifocal leucoencephalopathy with magnetic resonance imaging verification and therapeutic trials with interferon.
abstract: Progressive multifocal leucoencephalopathy was diagnosed by magnetic resonance imaging (MRI) and brain biopsy in a 44-year-old woman, for whom therapeutic trials with various antiviral agents were made. Despite early diagnosis and treatment, her neurological deterioration and extension of MRI-detectable lesions were not halted for a period of about 8 months. After the introduction of intrathecal beta-interferon therapy, her neurological status and MRI findings became stable and showed minimal improvement. Early diagnosis of this fatal disorder is important and intrathecal interferon therapy should be considered.
authors: Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo, Japan.
authors: K
authors: K
authors: Tashiro
authors: S
authors: S
authors: Doi
authors: F
authors: F
authors: Moriwaka
authors: Y
authors: Y
authors: Maruo
authors: M
authors: M
authors: Nomura
mesh_terms: D000328:Adult; D003561:Cytarabine / Q000627:therapeutic use; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed; D014740:Vidarabine / Q000627:therapeutic use
chemical_list: D007370:Interferon Type I; D003561:Cytarabine; D014740:Vidarabine