The effect of enkephalin dimers on body temperature in mice.
Short-lasting decrease in rectal temperature in mice after intraperitoneal administration of an enkephalin dimer, the so called double-enkephalin--(Tyr-D-Ala-Gly-Phe-NH)2 (D-ENK-O)--at dose 0.1, 0.5, 1, 2.5, 5, 10 and 20 mg/kg of body weight was observed. Another double-enkephalin--Tyr-D-Ala-Gly-Phe-NH-(CH2)3-HN-Phe-Gly-D-Ala-Tyr-- fai led to produce this effect. The hypothermic effect of D-ENK-O was almost completely reduced by naloxone which suggests an involvement of opiate receptors in the D-ENK-O produced hypothermia in mice.
Konecka
A M
AM
Department of Behavioral Physiology, Polish Academy of Sciences, Jastrzebiec.
Sroczynska
I
I
Lipkowski
A W
AW
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004745:Enkephalins / Q000494:pharmacology*; D008297:Male; D051379:Mice
D004745:Enkephalins; C053673:biphalin; C053674:tyrosyl-alanyl glycyl-phenylalaninamide-propyl-phenylalaninamide-glycyl-alanyl-tyrosine