title: A 10 year review of systemic lupus erythematosus in Singapore children.
abstract: A 10 year retrospective analysis of the clinical features and survival of 24 Singapore children with systemic lupus erythematosus was made. The female to male sex ratio was 11:1. The median age at diagnosis was 9.3 years (range: 3.5-17.6 years), and the median duration of follow-up was 3.6 years (range: 3 months-10 years). The common modes of presentation were prolonged fever and malar rash (both 46%). Renal involvement (71%) was frequent. There were six deaths, three from chronic renal failure, two from infection, and one from carditis. The overall survival at 5 years was 0.800 (s.e.m. = 0.090), and at 10 years 0.698 (s.e.m. = 0.103). The survival for lupus nephritis was 0.727 at 5 years (s.e.m. = 0.116), and 0.586 at 10 years (s.e.m. = 0.130). Although the 5 year survival rate is comparable with other series, there were more deaths after the first 5 years, and morbidity from the disease as well as from therapy was considerable.
authors: Department of Paediatrics, National University of Singapore.
authors: B W
authors: BW
authors: Lee
authors: H K
authors: HK
authors: Yap
authors: W C
authors: WC
authors: Yip
authors: P S
authors: PS
authors: Low
authors: A H
authors: AH
authors: Saw
authors: J S
authors: JS
authors: Tay
authors: H B
authors: HB
authors: Wong
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D012189:Retrospective Studies; D012846:Singapore