[Gastrin in the pathogenesis of ulcer disease].
The role of endogenous gastrin in the pathogenesis of "idiopathic" ulcer disease is difficult to determine; however, gastrin is probably only of limited importance besides various probable more important factors. In conditions associated with uncontrolled gastrin production by a gastrin secreting tumor or in cases in which the feedback regulation between gastrin release and intragastric pH is disturbed severe and recurrent ulcers may develop. Radioimmunological determination of serum gastrin levels enable to identify such cases of ulcer disease due to an excess of circulating gastrin.
Koop
H
H
Abteilung für Gastroenterologie und Stoffwechsel, Philipps-Universität Marburg.
D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000502:physiology*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000503:physiopathology; D010437:Peptic Ulcer / Q000209:etiology*; D012008:Recurrence; D015043:Zollinger-Ellison Syndrome / Q000503:physiopathology
D005755:Gastrins
Gastrin in der Pathogenese der Ulcuskrankheit.