Metabolism of bromobenzene. Analytical chemical and structural problems associated with studies of the metabolism of a model aromatic compound.
Our studies of bromobenzene metabolism have shown that the 3,4-oxide is metabolized to 3- and 4-bromophenol through an extended glutathione pathway. The mechanism of sulfur elimination from a dihydrobromobenzene metabolite is not known, although it is known that the aromatization reaction will occur in a 9000-g supernatant fraction of rat liver. The hepatotoxic and nephrotoxic metabolites of bromobenzene are most likely bromthiocatechols and a bromothiopyrogallol, respectively.
Horning
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EC
Institute for Lipid Research, Baylor College of Medicine, Houston, TX 77030.
Lertratanangkoon
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K
Horning
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MG
D000818:Animals; D001711:Biotransformation; D001969:Bromobenzenes / Q000097:blood / Q000378:metabolism* / Q000652:urine; D055598:Chemical Phenomena; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism; D002621:Chemistry; D002849:Chromatography, Gas; D008401:Gas Chromatography-Mass Spectrometry; D006168:Guinea Pigs; D007674:Kidney Diseases / Q000139:chemically induced / Q000378:metabolism; D010084:Oxidation-Reduction; D010636:Phenols / Q000378:metabolism; D051381:Rats; D013045:Species Specificity
D001969:Bromobenzenes; D010636:Phenols; C032036:bromobenzene