Flavin catabolites: identification and quantitation in human urine.
Riboflavin is the primary flavin excreted in human urine but significant amounts of 7 alpha-hydroxyriboflavin and lesser amounts of 8 alpha-hydroxyriboflavin are present and reflect tissue microsomal oxidations. A newly found flavin catabolite of an 8 alpha-sulfonyl type may reflect intake and/or turnover of such thioether-linked flavin as occurs in monoamine oxidase. Additionally, lesser amounts of 10-hydroxyethylflavin (indicative of intestinal microbial action on the vitamin) and traces of lumiflavin (arising from photodecomposition) constitute part of the remaining flavin, which acutely reflects level of intake.
Chastain
J L
JL
Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.
McCormick
D B
DB
D000328:Adult; D002725:Chloroform; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005415:Flavins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019800:Phenol; D010636:Phenols; D012256:Riboflavin / Q000031:analogs & derivatives / Q000652:urine; D013050:Spectrometry, Fluorescence; D014556:Urine / Q000032:analysis*
D005415:Flavins; D010636:Phenols; D019800:Phenol; D002725:Chloroform; D012256:Riboflavin