title: Biliary excretion of intravenous [14C] omeprazole in humans.
abstract: We have studied the biliary excretion of [14C] omeprazole in humans. The study was performed in eight healthy subjects and the technique used was based on multiple marker dilution principles with double-lumen tubes placed in both the stomach and intestine. The results obtained show a 16% biliary excretion of [14C] omeprazole. These data suggest a minimal "spillover" of omeprazole from the gastric mucosa into the gastric lumen in humans. The results also agree with previous data of the fecal recovery of radiolabeled omeprazole that suggest that the fecal excretion of intravenous omeprazole in humans is entirely accounted for by biliary excretion.
authors: Department of Surgery II, Sahlgrenska Sjukhuset, Göteborg, Sweden.
authors: T
authors: T
authors: Lind
authors: T
authors: T
authors: Andersson
authors: I
authors: I
authors: Skånberg
authors: L
authors: L
authors: Olbe
mesh_terms: D000328:Adult; D001646:Bile / Q000378:metabolism*; D002250:Carbon Radioisotopes; D005753:Gastric Mucosa / Q000378:metabolism; D005766:Gastrointestinal Contents / Q000032:analysis; D006801:Humans; D007275:Injections, Intravenous; D007441:Intubation, Gastrointestinal; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D002250:Carbon Radioisotopes; D009853:Omeprazole