Deconjugation of glycine-amidated bile salts does not occur in germfree rats.
After oral administration to germfree rats of cholyl-glycine-1-14C, deoxycholyl-glycine-1-14C and nor-ursocholyl-glycine-1-14C no significant amounts of 14CO2 are expired. This indicates that these bile salts are not significantly deamidated under physiological conditions in the rat organism outside the gastro-intestinal tract.
Borgström
B
B
Department of Physiological Chemistry, University of Lund, Sweden.
Midtvedt
T
T
Corrie
M
M
D000284:Administration, Oral; D000818:Animals; D001944:Breath Tests; D002793:Cholic Acids / Q000008:administration & dosage / Q000378:metabolism*; D005856:Germ-Free Life; D006000:Glycocholic Acid / Q000378:metabolism*; D006002:Glycodeoxycholic Acid / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D002793:Cholic Acids; D006002:Glycodeoxycholic Acid; D006000:Glycocholic Acid; C030712:ursocholic acid