title: Antitumour activity of purified arabinogalactan-peptidoglycan complex of the cell wall skeleton of Rhodococcus lentifragmentus.
abstract: Antitumour activity of arabinogalactan peptidoglycan (AP) complex (peptidoglycan and arabinogalactan liberated by an acid or alkaline treatment from Rhodococcus lentifragmentus AN-115 cell wall skeleton) was examined in mice and compared with that of the cell wall skeleton. The growth of syngeneic fibrosarcoma Meth A cells after implantation in BALB/c mice was significantly suppressed by AP complex, and also regressed after intratumoral injection of AP complex on days 1, 4 and 7 after tumour implantation. Although the activity of peptidoglycan was less than that of AP complex, peptidoglycan also showed both tumour-suppressive and regressive activities. Arabinogalactan did not show antitumour activity. It is interesting that peptidoglycan has an important role in the effect against tumours.
authors: Research Laboratories, Fujisawa Pharmaceutical Co. Ltd, Osaka, Japan.
authors: O
authors: O
authors: Hirai
authors: T
authors: T
authors: Fujitsu
authors: J
authors: J
authors: Mori
authors: H
authors: H
authors: Kikuchi
authors: S
authors: S
authors: Koda
authors: M
authors: M
authors: Fujioka
authors: Y
authors: Y
authors: Morimoto
mesh_terms: D000818:Animals; D002473:Cell Wall / Q000032:analysis / Q000276:immunology; D005354:Fibrosarcoma / Q000628:therapy*; D005685:Galactans / Q000032:analysis / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D010457:Peptidoglycan / Q000032:analysis / Q000627:therapeutic use*; D012074:Remission Induction; D012240:Rhodococcus / Q000032:analysis / Q000276:immunology*
chemical_list: D005685:Galactans; D010457:Peptidoglycan; C053856:arabinogalactan-peptidoglycan complex