title: Circadian rhythm of hepatic cytosolic and nuclear estrogen receptors.
abstract: The distribution of estrogen receptor between the cytosolic and nuclear compartments were evaluated in liver of male rats to determine whether a circadian rhythm exists. Cytosolic receptor reached a maximum level at 400 hours and a minimum at 2000 and 2400 hr. Nuclear receptor reached a maximum level at 800 hr and was lowest at 1600 and 2000 hr. Serum estradiol levels were also highest at 800 hr and lowest at 1600 hr. The variations in cytosolic and nuclear receptors are not reciprocal; in fact, the overall content of receptor in the liver is not constant and also displays a circadian rhythm.
authors: Veterans Administration Medical Centre, Pittsburgh, PA 15240.
authors: P K
authors: PK
authors: Eagon
authors: A
authors: A
authors: DiLeo
authors: L
authors: L
authors: Polimeno
authors: A
authors: A
authors: Francavilla
authors: D H
authors: DH
authors: Van Thiel
authors: F
authors: F
authors: Guglielmi
authors: T E
authors: TE
authors: Starzl
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002940:Circadian Rhythm; D003600:Cytosol / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011960:Receptors, Estrogen / Q000378:metabolism*
chemical_list: D011960:Receptors, Estrogen; D004958:Estradiol