Effect of a cholecystokinin antagonist on some effects of diazepam.
Dose responses were evaluated for the effects of diazepam alone or together with the cholecystokinin receptor antagonist CR 1409 on pentetrazole-induced convulsions, motor performance and spontaneous motor activity. The results obtained showed that the cholecytokinin antagonist potentiated the effects of diazepam on motor performance and the anticonvulsant activity of diazepam, while it did not affect spontaneous motor activity. The data presented are consistent with a role for cholecystokinin in some effects of diazepam.
Panerai
A E
AE
Department Pharmacology, School of Medicine, University of Milano, Italy.
Rovati
L C
LC
Bianchi
M
M
Bareggi
S R
SR
Mantegazza
P
P
D000818:Animals; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D003975:Diazepam / Q000097:blood / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005973:Glutamine / Q000031:analogs & derivatives*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011377:Proglumide / Q000031:analogs & derivatives* / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control
D005973:Glutamine; D002766:Cholecystokinin; D011377:Proglumide; C048181:lorglumide; D003975:Diazepam; D010433:Pentylenetetrazole