Structural relationships between the isoenzymes of human placental alkaline phosphatase: a serum factor converts M-PLAP to A- and B-PLAP.
A protein factor has been found in serum which converts the M form of placental alkaline phosphatase (PLAP) to the A and B forms. The identity of the conversion products has been confirmed by analysis of their dimers and polypeptides. Proteolysis is not implicated in this phenomenon. This report establishes microvillous M-PLAP as the precursor of the A and B forms.
Livingstone
J C
JC
Institute of Genetics, Glasgow University, UK.
Abu-Hasan
N S
NS
Clegg
R J
RJ
Henderson
S J
SJ
Marsden
H S
HS
Sutcliffe
R G
RG
D000469:Alkaline Phosphatase / Q000097:blood / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood / Q000302:isolation & purification*; D008871:Microvilli / Q000201:enzymology; D008970:Molecular Weight; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D011487:Protein Conformation
D007527:Isoenzymes; D000469:Alkaline Phosphatase