Antitumour activity of purified arabinogalactan-peptidoglycan complex of the cell wall skeleton of Rhodococcus lentifragmentus.
Antitumour activity of arabinogalactan peptidoglycan (AP) complex (peptidoglycan and arabinogalactan liberated by an acid or alkaline treatment from Rhodococcus lentifragmentus AN-115 cell wall skeleton) was examined in mice and compared with that of the cell wall skeleton. The growth of syngeneic fibrosarcoma Meth A cells after implantation in BALB/c mice was significantly suppressed by AP complex, and also regressed after intratumoral injection of AP complex on days 1, 4 and 7 after tumour implantation. Although the activity of peptidoglycan was less than that of AP complex, peptidoglycan also showed both tumour-suppressive and regressive activities. Arabinogalactan did not show antitumour activity. It is interesting that peptidoglycan has an important role in the effect against tumours.
Hirai
O
O
Research Laboratories, Fujisawa Pharmaceutical Co. Ltd, Osaka, Japan.
Fujitsu
T
T
Mori
J
J
Kikuchi
H
H
Koda
S
S
Fujioka
M
M
Morimoto
Y
Y
D000818:Animals; D002473:Cell Wall / Q000032:analysis / Q000276:immunology; D005354:Fibrosarcoma / Q000628:therapy*; D005685:Galactans / Q000032:analysis / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D010457:Peptidoglycan / Q000032:analysis / Q000627:therapeutic use*; D012074:Remission Induction; D012240:Rhodococcus / Q000032:analysis / Q000276:immunology*
D005685:Galactans; D010457:Peptidoglycan; C053856:arabinogalactan-peptidoglycan complex