Effect of aluminum on porphyrin metabolism in hemodialyzed patients.
In patients with renal failure and on chronic hemodialysis, serum aluminum, serum delta-aminolevulinic acid, serum porphobilinogen and erythrocyte zinc protoporphyrin (ZPP) are significantly elevated, whereas erythrocyte delta-aminolevulinic acid dehydratase activity (ALAD, values in percent) is significantly reduced. The last two parameters (ZPP and ALAD) are statistically related to serum aluminum concentration (Al-S), but only the correlation between Al-S and ALAD remains statistically significant after standardization for the degree of renal insufficiency (expressed in terms of urea level). This study does not support the hypothesis that the retention of aluminum is responsible for the increase of ZPP in uremic patients on dialysis. The disturbances of porphyrin metabolism found in patients with renal failure and on chronic dialysis are not similar to those observed in porphyria cutanea tarda.
Buchet
J P
JP
Unité de Toxicologie Industrielle et Médecine du Travail, Université Catholique de Louvain, Bruxelles, Belgique.
Lauwerys
R
R
Hassoun
A
A
Dratwa
M
M
Wens
R
R
Collart
F
F
Tielemans
C
C
D000328:Adult; D000368:Aged; D000535:Aluminum / Q000097:blood / Q000494:pharmacology*; D000622:Aminolevulinic Acid / Q000097:blood; D005260:Female; D006801:Humans; D011163:Hydroxymethylbilane Synthase / Q000097:blood; D008297:Male; D008875:Middle Aged; D011162:Porphobilinogen / Q000097:blood; D000623:Porphobilinogen Synthase / Q000097:blood; D011166:Porphyrins / Q000097:blood*; D011524:Protoporphyrins / Q000097:blood; D006435:Renal Dialysis / Q000009:adverse effects
D011166:Porphyrins; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D011162:Porphobilinogen; D000622:Aminolevulinic Acid; D000535:Aluminum; D011163:Hydroxymethylbilane Synthase; D000623:Porphobilinogen Synthase