Cerebellar glucose metabolism in chronic aphasia.
(18F)-Fluorodeoxyglucose PET was used to compare left/right cerebellar hemispheric glucose metabolism in 37 aphasic patients with left hemisphere lesions and 22 age-matched controls. Sixteen aphasic subjects showed cerebellar symmetry. Twenty-one aphasic subjects were found to have cerebellar metabolic asymmetry, which (1) resulted from an absolute reduction in local cerebral metabolic rates of glucose in the right cerebellar hemisphere; (2) was associated with left less than right glucose metabolic asymmetry in the frontal, parietal, caudate, and thalamic regions; (3) was associated with Broca's region and deep hemisphere structural damage to the internal capsule and basal ganglia; (4) related to reduced functional motor performance, spontaneous speech, naming, reading, and writing; and (5) included all Broca's aphasia subjects.
Metter
E J
EJ
Veteran's Administration Medical Center, Sepulveda, CA 91343.
Kempler
D
D
Jackson
C A
CA
Hanson
W R
WR
Riege
W H
WH
Camras
L R
LR
Mazziotta
J C
JC
Phelps
M E
ME
D001037:Aphasia / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology; D001519:Behavior; D002531:Cerebellum / Q000378:metabolism*; D002908:Chronic Disease; D005121:Extremities / Q000503:physiopathology; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007802:Language; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
D005947:Glucose