Histochemistry of the extracellular matrix of aging hyaline cartilage.
Cartilage proteoglycans (PGs) exhibit marked structural changes with increasing age. There is an increase in small PGs rich in KS as compared to larger PGs rich in chondroitin sulfate (CS) with increasing age. In the present study investigations have been performed to obtain more detailed information about the distribution of different glycosaminoglycans (GAGs). Changes were observed in the interterritorial matrix by means of ultrastructural visualization of PGs with acridin orange. The changes in the ultrastructural organization of the interterritorial matrix of costal cartilage are followed by significant changes in its mechanical properties.
Mallinger
R
R
Institute of Micromorphology and Electronemicroscopy, University of Vienna, Austria.
Stockinger
L
L
D000165:Acridine Orange; D000328:Adult; D000375:Aging / Q000502:physiology*; D002356:Cartilage / Q000032:analysis* / Q000648:ultrastructure; D002648:Child; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis*; D006651:Histocytochemistry; D006801:Humans; D006821:Hyaluronoglucosaminidase; D007231:Infant, Newborn; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged
D006025:Glycosaminoglycans; D006821:Hyaluronoglucosaminidase; D000165:Acridine Orange