Cholesterol embolization syndrome. Occurrence after intravenous streptokinase therapy for myocardial infarction.
Two patients developed the cholesterol embolization syndrome after coronary angiography and intravenous streptokinase therapy for acute myocardial infarction. Clinical manifestations included cyanosis, ulcers, gangrene of the hands and feet, myalgias, intestinal infarction, eosinophilia, and renal failure. One patient died; one has survived with chronic renal failure. Streptokinase therapy may expose atheromatous plaques to the circulation by lysing platelet-fibrin thrombi.
Schwartz
M W
MW
Department of Medicine, Veterans Administration Medical Center, Seattle, WA 98108.
McDonald
G B
GB
D002784:Cholesterol; D017023:Coronary Angiography; D004620:Embolism, Fat / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D013300:Streptokinase / Q000009:adverse effects* / Q000627:therapeutic use
D002784:Cholesterol; D013300:Streptokinase