title: Preservation of compliance in a small diameter microporous, silicone rubber vascular prosthesis.
abstract: Compliance is believed to be a significant factor in maintaining the patency of small diameter vascular grafts. This study evaluated the compliance changes with time of microporous Replamineform silicone rubber prostheses. The compliance of 15 canine femoral artery interpositions (4 mm internal diameter X 6 cm length) was measured by in-vivo electromagnetic rheoangiometry immediately following implantation and at intervals to eight months. At implantation, silicone rubber grafts were overcompliant (15.0 +/- 1.1% radial change/mmHg X 10(-2); mean +/- S.E.) compared to the proximal artery (7.7 +/- .6%). The compliance of the prostheses decreased within two weeks (6.3 +/- .9%) and remained isocompliant to the proximal artery for eight months. The compliance determinations for the silicone rubber grafts were compared with those from PTFE prostheses and vein grafts acquired by the same method in a previous study. The analysis demonstrates the preservation of isocompliance of the silicone rubber prostheses compared to the native arteries. In contrast, the minimally compliant vein grafts and PTFE prostheses continued to decrease in compliance following implantation. This microporous silicone rubber graft may improve the success of small internal diameter arterial reconstructions by eliminating failures caused by compliance mismatch between the artery and the prosthesis.
authors: Division of Vascular Surgery, Harbor/UCLA Medical Center, Torrance 90509.
authors: R A
authors: RA
authors: White
authors: S R
authors: SR
authors: Klein
authors: E C
authors: EC
authors: Shors
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis; D003187:Compliance; D004285:Dogs; D005069:Evaluation Studies as Topic; D006083:Graft Occlusion, Vascular / Q000453:epidemiology; D011474:Prosthesis Design; D012826:Silicone Elastomers; D013997:Time Factors
chemical_list: D012826:Silicone Elastomers