Atropine methylbromide and glycopyrrolate. A comparative study during reversal of neuromuscular block.
Two quaternary anticholinergics, atropine methylbromide (methylatropine bromide, MAB) and glycopyrrolate (ROBINUL) were compared as adjuncts to neostigmine for the reversal of residual nondepolarising neuromuscular block. MAB 0.75 mg in combination with neostigmine 2 mg produced a marked initial rise in heart rate. This was significantly greater than that produced by the administration of glycopyrrolate 0.4 mg with neostigmine. The antisialogogue effects of the two anticholinergics were identical and the central nervous system status of the patients was similar. It is concluded that, with the doses used in this study, glycopyrrolate is a superior alternative to MAB and is the drug of choice if a quaternary ammonium anticholinergic is required.
Dworacek
B
B
Academic Hospital Dijkzigt, Rotterdam, The Netherlands.
Rupreht
J
J
Bode
A
A
Walhout
M J
MJ
D000293:Adolescent; D000328:Adult; D001286:Atropine Derivatives / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects; D002648:Child; D004338:Drug Combinations; D005260:Female; D006024:Glycopyrrolate / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009388:Neostigmine / Q000494:pharmacology; D009466:Neuromuscular Blocking Agents / Q000378:metabolism*; D010276:Parasympatholytics / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D012472:Salivation / Q000187:drug effects
D001286:Atropine Derivatives; D004338:Drug Combinations; D009466:Neuromuscular Blocking Agents; D010276:Parasympatholytics; D011759:Pyrrolidines; D009388:Neostigmine; C006649:methylatropine; D006024:Glycopyrrolate