title: Exercise-induced pulmonary haemorrhage in the horse: results of a detailed clinical, post mortem and imaging study. III. Subgross findings in lungs subjected to latex perfusions of the bronchial and pulmonary arteries.
abstract: Latex was injected under pressure into bronchial and pulmonary arteries of the inflated lungs of Thoroughbreds and transverse sections taken to calculate the area of lesions resulting from exercise-induced pulmonary haemorrhage. Extensive areas of dense brown haemosiderin varying from 0 to 45 per cent of total lung volume were identified, predominantly in the dorsocaudal lungfields. Bronchial arterial proliferation appeared to have replaced the pulmonary supply in affected areas of the lung. Closely associated with the staining and bronchial arterialisation, there was widespread small airway disease. The most severely affected bronchioles contained thick gelatinous or mucous exudate or mucoid plugs and had grossly thickened walls. These lesions suggest that the source of haemorrhage in exercise-induced pulmonary haemorrhage is from alveolar capillaries anomalously supplied by the bronchial arterial circulation through the development of pathological shunts. Small airway disease is suggested as being of major importance in the pathogenesis of the disease and may have led to the initial proliferation of the bronchial circulation.
authors: Department of Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616.
authors: M W
authors: MW
authors: O'Callaghan
authors: J R
authors: JR
authors: Pascoe
authors: W S
authors: WS
authors: Tyler
authors: D K
authors: DK
authors: Mason
mesh_terms: D000818:Animals; D001981:Bronchial Arteries / Q000473:pathology; D006470:Hemorrhage / Q000473:pathology / Q000662:veterinary*; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D007840:Latex; D008168:Lung / Q000098:blood supply / Q000473:pathology*; D008171:Lung Diseases / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010477:Perfusion / Q000662:veterinary; D005082:Physical Exertion; D011651:Pulmonary Artery / Q000473:pathology
chemical_list: D007840:Latex