Antihepatotoxic actions of Cochlospermum tinctorium rhizomes.
The antihepatotoxic activity of the rhizomes of Cochlospermum tinctorium was investigated using carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Because the methanol and ethanol extracts of C. tinctorium rhizomes exhibited antihepatotoxic effects, the former was fractionated in order to elucidate the active constituents. Polyphenol compounds (gallic and ellagic acids) were detected in the active fractions and may account for much of the antihepatotoxic activity. Carotenoids could also be implicated in the activity of the total extracts.
Diallo
B
B
Laboratoire de Pharmacognosie, Université libre de Bruxelles, Belgium.
Vanhaelen
M
M
Kiso
Y
Y
Hikino
H
H
D000410:Alanine Transaminase / Q000032:analysis; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control; D002470:Cell Survival / Q000187:drug effects; D005688:Galactosamine / Q000037:antagonists & inhibitors / Q000633:toxicity; D008099:Liver / Q000187:drug effects*; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats
D010936:Plant Extracts; D005688:Galactosamine; D000410:Alanine Transaminase