Synthesis of new N-alkyl-2-mercapto-1-octylamines and respective disulfides.
Four new N-alkyl-2-mercapto-1-octylamine hydrochlorides were synthesized via the reaction of 1,2-epithio-octane with corresponding amines following by conversion to the hydrochlorides. The disulfides were obtained by oxidation of the respective thiols. Upon biological assay of the products for activity against infection by Schistosoma mansoni, only 2,2'-dithiobis(N-isobutyl-1-octylamine) exhibited activity.
Vieira Filho
S A
SA
Departamento de Bioquímica-Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte.
Nelson
D L
DL
Piló-Veloso
D
D
D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004220:Disulfides / Q000138:chemical synthesis*; D012550:Schistosoma mansoni / Q000187:drug effects
D000588:Amines; D004220:Disulfides; C008699:octylamine