Hypotensive effect of naloxone on high blood pressure induced by stress in the rat.
A naloxone-reversible enhancement of systolic blood pressure (BP) was induced in rats by application of three different types of stressor, i.e. intense light and sound, cold and foot-shock. In the case of labile high BP provoked by short-term isolation, the opiate antagonist naloxone (1 mg/Kg, i.p.) was also found to reverse hypertension. Naltrexone (2.5 mg/Kg, i.p.) also diminished high BP readings of briefly isolated rats. Conversely, blockade of the opiate receptor with naloxone did not alter elevated BP in cases of established hypertension (spontaneously hypertensive rats, deoxycorticosterone (DOCA)-salt rats and long-term isolated rats). These data can be taken as an evidence of opioid involvement at the onset of high BP readings induced by stress. However, once hypertension becomes established, the opioid system appears to recover its silent features.
Florentino
A
A
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid.
Jiménez
I
I
Naranjo
J R
JR
Urdín
M C
MC
Fuentes
J A
JA
D000161:Acoustic Stimulation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003080:Cold Temperature; D004597:Electroshock; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008297:Male; D009270:Naloxone / Q000494:pharmacology / Q000627:therapeutic use*; D009271:Naltrexone / Q000494:pharmacology / Q000627:therapeutic use; D010775:Photic Stimulation; D051381:Rats; D011919:Rats, Inbred Strains; D012934:Social Isolation; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology*; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology*
D009270:Naloxone; D009271:Naltrexone