Non-random distribution of Alu-family repeats in human chromosomes.
A phage lambda recombinant clone containing at least 8 Alu-family repeats (AFRs) has been isolated from a human genomic library, and DNA from the phage was used as a probe for in situ hybridization on G-banded human metaphase chromosomes of healthy donors and leukemic patients. Some chromosome bands show prominent clusters of silver grains in all individuals examined: 1p34, 1q23, 2q21-22, 10p14, 11p14, 10q21 and 11q14. The data suggest non-random distribution of AFRs in the human genome.
Filatov
L V
LV
Institute of Cytology, Academy of Sciences of USSR, Leningrad.
Mamayeva
S E
SE
Tomilin
N V
NV
D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000648:ultrastructure*; D004274:DNA, Recombinant; D006801:Humans; D007938:Leukemia / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid
D004274:DNA, Recombinant