A guide for mutagenicity testing using the dominant lethal assay.
The dominant lethal assay has been used and continues to be used to provide information about the effects of chemicals on the gonadal cells of male animals. Guidelines for conducting this test are useful but as with any guideline scientists should avoid interpreting them as protocols. Thus this document is a general approach to dominant lethal testing and should be used in conjunction with other available protocols and procedures.
Green
S
S
U.S. Food and Drug Administration, Washington, DC 20204.
Lavappa
K S
KS
Manandhar
M
M
Sheu
C J
CJ
Whorton
E
E
Springer
J A
JA
D000818:Animals; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D009152:Mutagenicity Tests / Q000592:standards*; D009153:Mutagens / Q000008:administration & dosage / Q000032:analysis*; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects; D012107:Research Design; D013223:Statistics as Topic
D009153:Mutagens