title: The impact of single versus repeated exposure of mice to Toxocara canis.
abstract: Infection with T. canis can alter dramatically the brain and behavior of the host. Previous results suggest that if the mammalian host is exposed either simultaneously to lead, or has a history of prior exposure to that toxic substance, the magnitude of the behavioral reaction to T. canis may be modified or even reduced. The present data suggest that the magnitude of both the behavioral and tissue/immune reactions may be less if the organism has multiple, instead of a single exposure, to T. canis. Lead, and perhaps other environmental toxicants may alter neurotropic products of the parasite, the behavior of the parasite, and/or reactivity of the host in the presence of the parasite. Such considerations may help explain, in part, the relative rarity of reported toxocariasis in humans, despite the fact that serological indices suggest that exposure to T. canis may be as high as 7% of the world population.
authors: Department of Psychology, State University of New York at Binghamton 13901.
authors: L J
authors: LJ
authors: Draski
authors: B
authors: B
authors: Summers
authors: R H
authors: RH
authors: Cypess
authors: R G
authors: RG
authors: Burright
authors: P J
authors: PJ
authors: Donovick
mesh_terms: D000818:Animals; D001196:Ascariasis / Q000503:physiopathology*; D001522:Behavior, Animal / Q000502:physiology*; D001835:Body Weight; D001921:Brain / Q000469:parasitology / Q000473:pathology; D007668:Kidney / Q000469:parasitology / Q000473:pathology; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008168:Lung / Q000469:parasitology / Q000473:pathology; D051379:Mice; D009929:Organ Size; D013550:Swimming; D014120:Toxocariasis / Q000473:pathology / Q000503:physiopathology*