Evaluation of triacontanol-containing compounds as anti-inflammatory agents using guinea pig models.
A mixture of the aliphatic alcohol, triacontanol, and other chemically associated naturally occurring alcohols was applied to the denuded dorsal cutaneous surface of guinea pigs to evaluate anti-inflammatory activity. In the setting of a chemical irritation with 2% croton oil and in an allergic dermatitis created with dinitrochlorobenzene sensitization and challenge, the triacontanol-containing preparation was significantly more effective than vehicle alone (DHL skin cream) but not as effective as 0.05% Diprolene ointment. Lymphocyte stimulation was studied by tritiated thymidine uptake and morphologic examination for blast transformation. When triacontanol-containing compounds were solubilized in aqueous media, effects on lymphocytes were insignificant. When solubilized in ethanol, there was a marked effect on thymidine uptake but not on blast transformation when compared to parallel controls.
McBride
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PT
Division of Dermatology, University of Utah School of Medicine, Salt Lake City.
Clark
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Krueger
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GG
D000818:Animals; D000893:Anti-Inflammatory Agents; D001623:Betamethasone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D003877:Dermatitis, Contact / Q000188:drug therapy; D005233:Fatty Alcohols / Q000494:pharmacology* / Q000627:therapeutic use; D006168:Guinea Pigs; D008213:Lymphocyte Activation / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D005233:Fatty Alcohols; C047578:1-triacontanol; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone