title: Increased respiratory frequency and variability in high risk babies who die of sudden infant death syndrome.
abstract: We have tested the hypothesis that autonomic instability, reflected in increased variability of heart rate and respiratory frequency, characterized high risk babies who died of sudden infant death syndrome. Using computer-based methods, we compared the power spectra of instantaneous heart rate and respiration on coded tape recordings from seven asymptomatic siblings and 10 babies with symptomatic apnea who died of sudden infant death syndrome to 34 age- and sex-matched controls. We confirmed our previous observation of increased respiratory bandwidth, an index of variability in respiratory frequency (p = 0.009) but failed to confirm our finding of increased low frequency fluctuations in heart rate (p = 0.18). In addition, we found an increase in mean respiratory frequency during quiet breathing (p = 0.001) and a significant relationship between respiratory bandwidth and mean respiratory frequency (r = 0.604, p = 0.0002). These variables along with those from a previous analysis of the same data base yield a discriminant function with 82% sensitivity and 100% specificity. These results confirm previous suggestions that high risk babies who die of sudden infant death syndrome exhibit autonomic instability.
authors: Pediatric Pulmonary Unit, Massachusetts General Hospital 02114.
authors: D C
authors: DC
authors: Shannon
authors: D H
authors: DH
authors: Kelly
authors: S
authors: S
authors: Akselrod
authors: K M
authors: KM
authors: Kilborn
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology; D001699:Biometry; D001919:Bradycardia / Q000503:physiopathology; D003951:Diagnostic Errors; D005260:Female; D006339:Heart Rate; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012119:Respiration; D013398:Sudden Infant Death / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*