[Morphometric analysis of the aortic endothelium of rats exposed to prolonged hypokinesia].
Twenty-four white rats were exposed to 30-, 60- and 100-day hypokinesia. Using the stereological technique, film preparations of their aortic endothelium were examined for the mean area of endothelial cells, nuclei and cytoplasm. Also, the content of endothelial cells showing karyopyknosis, karyolysis or binuclear structures was measured morphometrically. As compared to the matched controls, the number of cells with karyopyknosis, karyolysis and two nuclei increased significantly at every time interval studied. On hypokinesia day 30, the area of endothelial cells, nuclei and cytoplasm was greater than that in the controls. On hypokinesia days 60 and 100, the cell size was within the normal limits and the nuclear size was smaller. This lead to a decrease of the nucleus-plasma ratios. Together with other factors responsible for hypercholesterinemia, the above changes in the endothelial layer may facilitate atherosclerotic lesions of the vascular wall during prolonged hypokinesia.
Gansburgskiĭ
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D000818:Animals; D001011:Aorta / Q000166:cytology*; D004730:Endothelium, Vascular / Q000166:cytology; D007103:Immobilization; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D051381:Rats; D013997:Time Factors
Morfometricheskiĭ analiz éndoteliia aorty krys v usloviiakh dlitel'noĭ gipokinezii.