title: Basic fibroblast growth factor is present in cultured human retinoblastoma cells.
abstract: Cultured human retinoblastoma cells express the basic fibroblast growth factor (bFGF) gene and they produce material similar, if not identical, to bFGF. The retinoblastoma-derived bFGF can stimulate the proliferation of capillary endothelial cells and this process is inhibited by anti-bFGF antibodies. It is conceivable that the retinoblastoma-derived bFGF contributes to the neovascularization of retinoblastomas.
authors: Cancer Research Institute M-1282, University of California Medical Center, San Francisco 94143.
authors: L
authors: L
authors: Schweigerer
authors: G
authors: G
authors: Neufeld
authors: D
authors: D
authors: Gospodarowicz
mesh_terms: D002460:Cell Line; D004247:DNA; D005134:Eye Neoplasms / Q000378:metabolism* / Q000473:pathology; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006801:Humans; D009693:Nucleic Acid Hybridization; D012175:Retinoblastoma / Q000378:metabolism* / Q000473:pathology
chemical_list: D005346:Fibroblast Growth Factors; D004247:DNA