[Differences in the gene structure of the matrix protein and hemagglutinin in remantadine-resistant and -sensitive variants of the influenza virus type A FPV].
The oligonucleotide mapping technique and RNA-RNA hybridization revealed structural differences between the HA- and M-protein genes of two variants of influenza A FPV, remantadine-sensitive and remantadine-resistant ones. A quantitative estimation of the structural divergence of the two influenza FPV pairs of genes was carried out. The possible functional role of the differences in the structure of the HA- and M-protein genes of the two FPV variants is discussed.
Shilov
A A
AA
Chaĭka
O V
OV
Starov
A I
AI
Moĭsiadi
S A
SA
Bukrinskaia
A G
AG
D000218:Adamantane / Q000031:analogs & derivatives*; D004352:Drug Resistance, Microbial / Q000235:genetics; D005814:Genes, Viral / Q000187:drug effects*; D005815:Genetic Code / Q000187:drug effects; D014644:Genetic Variation / Q000187:drug effects*; D006389:Hemagglutinins, Viral / Q000235:genetics*; D009980:Influenza A virus / Q000187:drug effects / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009842:Oligopeptides / Q000235:genetics; D010449:Peptide Mapping; D012367:RNA, Viral / Q000235:genetics; D012299:Rimantadine / Q000494:pharmacology*; D014763:Viral Matrix Proteins / Q000235:genetics*
D006389:Hemagglutinins, Viral; D009842:Oligopeptides; D012367:RNA, Viral; D014763:Viral Matrix Proteins; D012299:Rimantadine; D000218:Adamantane
Razlichiia v strukture genov matrikskogo belka i gemaggliutinina ustoĭchivogo i chuvstvitel'nogo k remantadinu variantov virusa grippa tipa FPV.