The effect of ketanserin on blood pressure and platelets during cardiopulmonary bypass.
Ketanserin, a serotonin antagonist, was used to control blood pressure during cardiopulmonary bypass in 12 patients having cardiac surgery. The drug was administered as a 10 mg bolus followed by a continuous infusion of either 40, 80, or 120 mg/hr to maintain mean arterial blood pressure below 70 mm Hg. There were 16 hypertensive episodes of which 15 (93.7%) were successfully controlled with ketanserin. Mean arterial pressure decreased significantly from an average of 72 +/- 3 to 52 +/- 9 mm Hg after 1 min. The effect that ketanserin had on platelets was also evaluated. Neither adverse nor salutary effects were seen in the platelet count, though a significant inhibition of serotonin-induced platelet aggregation was observed. Ketanserin proved effective for controlling hypertension during cardiopulmonary bypass but, despite inhibition of serotonin-induced platelet aggregation, it did not prevent thrombocytopenia.
Lichtenthal
P R
PR
Department of Anesthesia, School of Medicine, Northwestern University, Chicago, Illinois.
Wade
L D
LD
Rossi
E C
EC
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000517:prevention & control*; D007650:Ketanserin / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D012701:Serotonin / Q000009:adverse effects; D013921:Thrombocytopenia / Q000517:prevention & control*; D014655:Vascular Resistance / Q000187:drug effects
D012701:Serotonin; D007650:Ketanserin