[Epidermolysis bullosa hereditaria dystrophica (Hallopeau-Siemens). Case report and therapy trial with (+)-cyanidanol-3 in 3 patients].
The diagnosis of hereditary epidermolysis bullosa dystrophica (Hallopeau-Siemens) in three patients was confirmed by clinical and histological means as well as by electron microscopy. The clinical course was followed for many years. Since (+)-cyanidanol-3 has been shown to reduce the susceptibility of collagen to mammalian collagenase under in vitro conditions, (+)-cyanidanol-3 was used to treat the three patients for a period of 27 weeks. A decrease in the amount of blistering was observed in all three patients.
Schurig
V
V
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
Krieg
T
T
Landthaler
M
M
Braun-Falco
O
O
D000328:Adult; D002392:Catechin / Q000008:administration & dosage*; D002648:Child; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004820:Epidermolysis Bullosa / Q000188:drug therapy* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male
D002392:Catechin
Epidermolysis bullosa hereditaria dystrophica (Hallopeau-Siemens). Fallbericht und Therapieversuch mit (+)-Cyanidanol-3 bei drei Patienten.