title: Routine synthesis of carbon-11-carboxyl-labeled L-dopa.
abstract: Carbon-11-carboxyl-labeled L-dopa has been synthesized by the modified Bucherer-Strecker method. The reaction mixture was first purified by chiral HPLC followed by deprotection using hydriodic acid. The entire procedure was performed in a remotely operated system which gave the product in 28% radiochemical yield (decay corrected) in an overall synthesis time of 55-60 min.
authors: UBC/TRIUMF Program on Positron Emission Tomography, Vancouver, Canada.
authors: M J
authors: MJ
authors: Adam
authors: J R
authors: JR
authors: Grierson
authors: T J
authors: TJ
authors: Ruth
authors: K
authors: K
authors: Pedersen
authors: B D
authors: BD
authors: Pate
mesh_terms: D002250:Carbon Radioisotopes; D007553:Isotope Labeling / Q000379:methods*; D007980:Levodopa
chemical_list: D002250:Carbon Radioisotopes; D007980:Levodopa