Problems in identification of Campylobacter jejuni associated with acquisition of resistance to nalidixic acid.
In a patient with campylobacteriosis, we observed development of resistance to nalidixic acid and norfloxacin under adequate treatment with the latter antibiotic. Isolates before and after treatment differed in their total protein profile but were otherwise identical with respect to enzymatic activity, serotype, crude membrane protein profiles, and other phenotypic characteristics.
Altwegg
M
M
Department of Medical Microbiology, University of Zurich, Switzerland.
Burnens
A
A
Zollinger-Iten
J
J
Penner
J L
JL
D000328:Adult; D001426:Bacterial Proteins / Q000032:analysis; D002169:Campylobacter Infections / Q000188:drug therapy / Q000382:microbiology*; D002168:Campylobacter fetus / Q000032:analysis / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D004352:Drug Resistance, Microbial; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D009643:Norfloxacin / Q000494:pharmacology* / Q000627:therapeutic use
D001426:Bacterial Proteins; D009268:Nalidixic Acid; D009643:Norfloxacin