Potency of several non-steroidal antiinflammatory drugs on airways responses to histamine.
The effects of four non-steroidal antiinflammatory drugs (NSAIDs, indomethacin, flufenamate, aspirin and phenylbutazone) were investigated in anesthetized guinea-pigs. Bronchoconstriction (increased airways resistance and decreased conductance and compliance) was obtained to histamine (1-3 micrograms/kg i.v.). Each of the NSAIDs (0.1-20 mg/kg i.v.) enhanced bronchoconstriction to histamine. Maximum effects were obtained 12-44 min after administration of the NSAID. The order of potency of the drugs in causing a 50% increase in resistance responses to histamine was indomethacin greater than flufenamate greater than aspirin greater than phenylbutazone.
Mitchell
H W
HW
Department of Physiology, University of Western Australia, Nedlands.
Adcock
J
J
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D008170:Lung Compliance / Q000187:drug effects; D008297:Male; D012119:Respiration / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006632:Histamine