[Role of the microsomal ethanol-oxidizing system in regulating linoleoyl CoA desaturase activity in long-term ethanol loading].
Long-term ethanol load resulted in a decrease of the rat liver linoleyl desaturase activity and the activation of MEOS accompanied by an increase in the activity of NADPH-dependent chain and the initial steps of NADH-dependent chain of microsomal electron transport, indicating electron transfer from NADH to cytochrome P-450. It is suggested that, when the main potential of NADH- and NADPH-dependent chains is transferred to microsomal ethanol oxidation, insufficient electron supply for linoleyl-CoA desaturase decreases the activity of this process.
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D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D015786:Cytochromes b5; D004579:Electron Transport; D000431:Ethanol / Q000378:metabolism*; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D050602:Linoleoyl-CoA Desaturase; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats
D003573:Cytochrome b Group; D000431:Ethanol; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D044943:Fatty Acid Desaturases; D050602:Linoleoyl-CoA Desaturase; D009247:NADH, NADPH Oxidoreductases
Rol' mikrosomnoĭ étanolokislialiushcheĭ sistemy v reguliatsii aktivnosti linoleil-KoA-desaturazy pri dlitel'noĭ nagruzke étanolom.