Type 2 diabetes. Primary vascular disorder with metabolic symptoms?
It is postulated that in the resting state insulin-dependent tissue uptake of glucose is limited by the rate of blood flow, capillary permeability, and the number of perfused capillaries in the skeletal muscles. A mathematical model, simulating these relations, is developed. According to this model, changes in the indicated parameters might cause type 2 diabetes.
Ganrot
P O
PO
Department of Clinical Chemistry, Orebro Medical Center Hospital, Sweden.
Curman
B
B
Kron
B
B
D001693:Biological Transport, Active; D001783:Blood Flow Velocity; D002196:Capillaries / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D004058:Diffusion; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D007700:Kinetics; D008954:Models, Biological; D009132:Muscles / Q000098:blood supply / Q000378:metabolism; D011972:Receptor, Insulin / Q000378:metabolism
D011972:Receptor, Insulin; D005947:Glucose