[Protective action of an antioxidant of the 3-hydroxypyridine class on the contractility and electrogenesis of the heart muscle in hypoxia and reoxygenation].
The effect of SD-6, a 3-hydroxypyridine antioxidant, on the pattern of variation in contraction intensity, contracture and membrane potentials were assessed in experimental studies on isolated left ventricular papillary muscles of rats, exposed to hypoxia and reoxygenation. The antioxidant considerably limited hypoxic and reperfusion contracture, its efficiency increasing with a concentration reduced to 10(-7) g/ml. Contraction intensity and duration of action potentials, diminished by hypoxia, were only recovered by reoxygenation, if the antioxidant was present. It is assumed that the recovery of action potentials by reoxygenation in the presence of SD-6 may result from normalization of ATP-dependent outgoing current through the kappa channels, activated by ATP deficiency. The antioxidant capacity for levelling diverse durations of action potentials between normal and ischemic areas is evidence of an important contribution of free-radical mechanisms to the development of reoxidation-induced recirculation arrhythmias.
Vasilets
L A
LA
Mokh
V P
VP
Bogdanov
G N
GN
Guseva
T I
TI
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D010210:Papillary Muscles / Q000187:drug effects; D010847:Picolines / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats
D000975:Antioxidants; D010847:Picolines; D011725:Pyridines; C023500:3-hydroxypyridine; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Zashchitnoe deĭstvie antioksidantov iz klassa 3-oksipiridinov na sokratimost' i élektrogenez serdechnoĭ myshtsy pri gipoksii i reoksigenatsii.