title: Interaction of sex steroids and prolactin on phosphatases, transaminases, and citric acid in the ventral prostate of male albino rats.
abstract: The interaction of androgens, testosterone propionate (TP), and dihydrotestosterone (DHT) with prolactin (PRL) and estradiol-17 beta (E2) on phosphatases, transaminases, and citric acid were studied in the ventral prostate of prepubertal and adult intact and castrated rats. None of the secretory products studied were affected by androgens or their combinations with E2/PRL in prepubertal rats except for the increase observed in organ weight and DNA content. However, in adults the hormonal combinations produced some significant changes. Among the secretory products, phosphatases, glutamate oxaloacetic transaminase (GOT), and citric acid increased significantly in adult rats after the administration of TP/DHT. Glutamate pyruvic transaminase (GPT) required PRL along with TP/DHT to show an appreciable increment in intact adult rats. The synergistic effect of PRL with androgens was observed in the adult ventral prostatic secretory acid phosphatase and citric acid. Unlike PRL, E2 in combination with androgens produced an antagonistic effect in intact adult rats, which was well pronounced in the case of prostatic weight, DNA content secretory acid phosphatase, and citric acid. None of the androgens or their combination with PRL produced any significant change in DNA content compared to intact controls.
authors: Department of Endocrinology, P.G. Institute of Basic Medical Sciences, University of Madras, Taramani, India.
authors: N
authors: N
authors: Srinivasan
authors: M M
authors: MM
authors: Aruldhas
authors: P
authors: P
authors: Govindarajulu
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism*; D000375:Aging; D000818:Animals; D002369:Castration; D002951:Citrates / Q000378:metabolism*; D019343:Citric Acid; D004247:DNA / Q000032:analysis; D004357:Drug Synergism; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D000637:Transaminases / Q000378:metabolism*
chemical_list: D002951:Citrates; D012739:Gonadal Steroid Hormones; D019343:Citric Acid; D004247:DNA; D000637:Transaminases; D000135:Acid Phosphatase