title: Bone marrow response in cattle with chronic dermatitis caused by Psoroptes ovis.
abstract: Six Hereford heifer calves were infested with Psoroptes ovis and compared to six uninfested control calves. Infested calves developed severe exudative dermatitis which covered 100% of the body surface by 7 weeks after infestation. They developed moderate nonregenerative anemia, decreased numbers of neutrophils and lymphocytes, and increased plasma protein and fibrinogen concentrations. Sternal marrow core biopsies taken 7 weeks after infestation were 75 to 90% cellular, while cores from uninfested calves were 10 to 20% cellular. Comparison of myelograms between the two groups of calves revealed increased M:E ratio, myelocyte and metamyelocyte hyperplasia with depletion of mature neutrophils and eosinophils in the P. ovis-infested calves. It was concluded that P. ovis-infested calves develop myeloid hyperplasia and that mange-related neutropenia is not due to bone marrow suppression by a mite or scab-associated toxin.
authors: Department of Veterinary Pathobiology, Ohio State University, Columbus.
authors: P C
authors: PC
authors: Stromberg
authors: F S
authors: FS
authors: Guillot
mesh_terms: D000380:Agranulocytosis / Q000662:veterinary*; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology*; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000473:pathology*; D004906:Erythrocyte Count / Q000662:veterinary; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D007958:Leukocyte Count / Q000662:veterinary; D008924:Mite Infestations / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D009503:Neutropenia / Q000209:etiology / Q000662:veterinary*
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins; D005340:Fibrinogen