[Effect of Broncho-Vaxom on serum IgE and IgG levels in patients with bronchial asthma and chronic obstructive lung disease. A placebo-controlled double-blind study].
In a double-blind study of 33 patients with bronchial asthma or chronic obstructive pulmonary disease, of whom 17 had proven atopies, the results showed a distinct diminution of the mean IgE level in the atopic patients at the end of 1-month treatment with Broncho-Vaxom, though not attaining statistical significance (trend with p less than 0.10), compared to a slight increase under placebo. Simultaneously the mean IgG level increased slightly in the atopic patients under Broncho-Vaxom and remained stable in the patients under placebo (p less than 0.10). The IgE and IgG values of the non-atopic patients in both treatment groups remained practically unchanged. Considering the small number of patients in each group, and the clear tendency towards a diminution of the IgE level, it may be concluded that the administration of Broncho-Vaxom to atopic patients does not lead to an increased IgE level but, on the contrary, seems rather to favour a decrease.
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D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D001249:Asthma / Q000276:immunology* / Q000628:therapy; D001419:Bacteria; D002457:Cell Extracts; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D008173:Lung Diseases, Obstructive / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D000095983:Bacterial Lysates
D000276:Adjuvants, Immunologic; D002457:Cell Extracts; D007073:Immunoglobulin E; D007074:Immunoglobulin G; C030259:Broncho-Vaxom; D000095983:Bacterial Lysates
Einfluss von Broncho-Vaxom auf die IgE- und IgG-Serumspiegel bei Patienten mit Asthma bronchiale und chronisch-obstruktiver Lungenerkrankung. Eine placebo-kontrollierte Doppelblindstudie.