An attempt to treat rabies encephalitis in monkeys with intrathecal live rabies virus RV 675. Brief report.
A highly attenuated rabies virus, RV 675, proved innocuous but immunogenic when injected intrathecally into monkeys by the lumbar route. Attempts to use this virus to modify the course of fatal rabies encephalitis in monkeys were inconclusive possibly because of the brief encephalitic illness. Further studies are indicated to investigate RV 675 as a candidate therapeutic agent for rabies encephalitis.
Warrell
M J
MJ
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Ward
G S
GS
Elwell
M R
MR
Tingpalapong
M
M
D000818:Animals; D004660:Encephalitis / Q000209:etiology / Q000628:therapy*; D007278:Injections, Spinal; D008252:Macaca fascicularis; D008253:Macaca mulatta; D011818:Rabies / Q000628:therapy*; D011819:Rabies Vaccines / Q000627:therapeutic use*; D011820:Rabies virus / Q000276:immunology; D014613:Vaccines, Attenuated
D011819:Rabies Vaccines; D014613:Vaccines, Attenuated