title: Radioisotopic flow scanning for portal blood flow and portal hypertension.
abstract: The use of a simple, noninvasive, isotope scanning technique for the determination of relative portal blood flow and detection of portal hypertension is described. Using this technique the presence of portal hypertension was demonstrated in seven of nine patients known to have elevated portal venous pressure. By contrast, esophageal varices were demonstrated in only five of these patients, illustrating the potential value of the method. Furthermore, this technique has been adapted to the study of portal blood flow in patients with myeloproliferative disorders with splenomegaly but without disturbances in hepatic architecture. Results demonstrate that the high relative splenic flow resulting from the presence of splenomegaly may in turn be associated with elevated relative portal blood flow and portal hypertension. The theoretic reasons for the development of flow-related portal hypertension and its relationship to splenic blood flow are discussed.
authors: Department of Medicine, Johannesburg Hospital, South Africa.
authors: C S
authors: CS
authors: Hesdorffer
authors: W R
authors: WR
authors: Bezwoda
authors: M D
authors: MD
authors: Danilewitz
authors: J D
authors: JD
authors: Esser
authors: M
authors: M
authors: Tobias
mesh_terms: D001783:Blood Flow Velocity; D006801:Humans; D006975:Hypertension, Portal / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D009196:Myeloproliferative Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D011168:Portal System / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011877:Radionuclide Imaging; D013667:Technetium; D017556:Technetium Compounds; D014001:Tin; D017971:Tin Compounds
chemical_list: D017556:Technetium Compounds; D017971:Tin Compounds; C033493:technetium Tc 99m tin colloid; D013667:Technetium; D014001:Tin