The choice of anticoagulation in pediatric patients with the St. Jude Medical valve prostheses.
Between February 1982 and January 1984 27 St. Jude Medical cardiac valve prostheses were implanted in 24 children ranging in age from 5 to 20 years (mean 12.38 years). There were 10 isolated aortic valve replacements, 14 isolated mitral valve replacements and one triple valve replacement (aortic, mitral and tricuspid). There was one operative and four late deaths. All patients were maintained on Aspirin and Dipyridamole from the early postoperative period. There were six documented thromboembolic events occurring in five patients. There were 0.68 thromboembolic events per patient year in the aortic valve group and 0.19 events in the mitral valve group. Because of the significant incidence of thromboembolic events in our patients, we now recommend universal anticoagulation with Coumadin in all pediatric age patients in whom the St. Jude Medical prosthesis is implanted.
Serra
A J
AJ
Department of Thoracic Surgery, Presbyterian-University of Pennsylvania Medical Center, Philadelphia.
McNicholas
K W
KW
Olivier
H F
HF
Boe
S L
SL
Lemole
G M
GM
D000293:Adolescent; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D001021:Aortic Valve; D001241:Aspirin / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D004176:Dipyridamole / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008943:Mitral Valve; D011182:Postoperative Care / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control; D013923:Thromboembolism / Q000453:epidemiology / Q000517:prevention & control; D014261:Tricuspid Valve; D014859:Warfarin / Q000008:administration & dosage
D000925:Anticoagulants; D014859:Warfarin; D004176:Dipyridamole; D001241:Aspirin