Intoxication with sulindac, tiaramide hydrochloride and diclofenac sodium.
Overdosage intoxication of sulindac, tiaramide and diclofenac caused excitability of central nervous system, followed by unconsciousness. The case was treated with ordinary therapies and direct hemoperfusion (DHP). Serum concentrations of these drugs and their metabolites were correlated well with the clinical symptoms. DHP may be effective to eliminate these drugs and their metabolites.
Harima
Y
Y
Department of Pharmacy, Yamaguchi University Hospital, Japan.
Maekawa
T
T
Miyauchi
Y
Y
Tsutsui
T
T
Sakabe
T
T
Koshiro
A
A
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000506:poisoning*; D052160:Benzothiazoles; D004008:Diclofenac / Q000506:poisoning; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D010879:Piperazines / Q000506:poisoning; D013406:Suicide, Attempted; D013467:Sulindac / Q000506:poisoning
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052160:Benzothiazoles; D010879:Piperazines; D004008:Diclofenac; D013467:Sulindac; C003468:tiaramide