[Possibilities for the in vitro evaluation of bioavailability. 5. Compact peroral agents with basic drugs].
Lipophilic, basic drugs can be transported across lipoid-membrane even if the part of the substance being not ionized in the solution is very low. Therefore the resorption model can be used for the control of drugs containing the substances as salts. In the case of 4 substances no differences could be found concerning half transport time between the aqueous solutions and the drugs.
Fürst
W
W
Sektion Pharmazie der Martin-Luther-Universität, Halle-Wittenberg, Halle, Saale.
Neubert
R
R
Bendas
C
C
Lärm
M
M
König
A
A
D000284:Administration, Oral; D001682:Biological Availability; D001693:Biological Transport, Active; D002626:Chemistry, Pharmaceutical; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption; D008954:Models, Biological
Möglichkeiten zur in-vitro-Beurteilung der Bioverfügbarkeit. 5. Mitteilung: Untersuchung von festen Peroralia mit basischen Wirkstoffen.