Effect of verapamil on pulmonary function changes induced by fluid overloading in normal subjects.
The acute effects of the intravenous administration of 10 mg verapamil on pulmonary function changes induced by rapid saline infusion were studied in six normal subjects. Rapid intravenous fluid overloading caused on increase of closing volume (from 6.55 +/- 1.74 to 9.53 +/- 1.77%, p less than 0.05). After verapamil, the closing volume did not increase after infusion in three subjects and the mean increase was not significant (7.08 +/- 1.82 to 8.43 +/- 1.86%). These results suggest that the rapid administration of intravenous verapamil blunts respiratory function abnormalities caused by overhydration interstitial lung oedema.
Baldi
S
S
Service of Respiratory Physiopathology, Molinette Hospital, Turin, Italy.
Scappaticci
E
E
Coni
F
F
Bucca
C
C
Rolla
G
G
D000328:Adult; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000502:physiology; D008297:Male; D011654:Pulmonary Edema / Q000503:physiopathology*; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil