Synthesis of thiazole derivatives with positive inotropic effect.
Thiazole derivatives with potential positive inotropic effect were synthesized. The highest activity (medium positive inotropic effect) was exhibited by ethyl 2-(2-hydroxyethylamino)-4-phenylthiazole-5-carboxylate (3b) of which several derivatives have been prepared. Among these derivatives only those which could presumably easily removed in the living organism to give 3b exhibited a medium positive inotropic effect (6, 8b). It was assumed that the effect of 3b had a beta-agonist character.
Kosáry
J
J
Institute for Drug Research, Budapest, Hungary.
Kasztreiner
E
E
Rablóczky
G
G
Vitális
B
B
D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis*; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D006339:Heart Rate / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D002316:Cardiotonic Agents; D013844:Thiazoles; D011433:Propranolol