[Experimental studies of local therapy of Candida keratomycosis with amphotericin B].
The efficiency of Amphotericin B drops was studied using a newly developed keratomycosis model (defined strain Candida albicans DSM 70010, which leads reproducibly to a corneal infection with descemetocele without prior local or systemic immunosuppression in the rabbit). Penetration of the drug (administered ten times a day) into the cornea and aqueous humor was only demonstrated after abrasion of the corneal epithelium. Three groups were studied: (I) therapy with abrasion, (II) therapy without abrasion, and (III) a control group. Both clinically (descemetocele or perforation, hypopyon) and with regard to microbiology (reculture of Candida) the results obtained in Group I were significantly better than those obtained in Group II (p less than 0.001). Repeated corneal abrasion is therefore recommended for treatment of Candida keratitis with Amphotericin B.
Behrens-Baumann
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Abteilung Augenheilkunde, Medizinische Einrichtungen der Universität Göttingen.
Uter
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Ansorg
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R
D000666:Amphotericin B / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000818:Animals; D001682:Biological Availability; D002177:Candidiasis / Q000188:drug therapy*; D007634:Keratitis / Q000188:drug therapy*; D008297:Male; D009883:Ophthalmic Solutions; D011817:Rabbits
D009883:Ophthalmic Solutions; D000666:Amphotericin B
Experimentelle Untersuchungen zur lokalen Therapie der Candida-Keratomykose mit Amphotericin B.