Development of presenile cataracts in association with high serum levels of phenytoin.
We report the occurrence of bilateral cataracts in a young adult which developed shortly after documented high serum levels of phenytoin. There are two previous reports (five patients) in the literature implicating this drug as a cause of cataract formation in humans. This is the first case in which toxic levels were measured.
Mathers
W
W
Department of Ophthalmology, Georgetown University Medical School, Washington, DC.
Kattan
H
H
Earll
J
J
Lemp
M
M
D000328:Adult; D002386:Cataract / Q000139:chemically induced*; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use
D010672:Phenytoin