Increased cortical serotonin-2 (5-HT-2) receptors in the iminodipropionitrile (IDPN)-model of persistent dyskinesia in the rat.
Chronic treatment with IDPN causes a persistent behavioral syndrome which is reminiscent of the head shakes, backward locomotion, and hyperactivity observed after acute injection of 5-HT agonists in rodents. Evaluation of the characteristics of 5-HT receptors, using mianserin to label 5-HT-2 receptors, revealed a significant increase in the number of binding sites in the cortices of rats which demonstrated the IDPN-induced syndrome. There was an associated decrease in the affinity of the receptors. These results add more evidence to support the idea that the serotonergic system may play a significant role in the manifestation of the persistent abnormalities induced by IDPN.
Cadet
J L
JL
Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY 10032.
Rothman
R B
RB
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004195:Disease Models, Animal; D004409:Dyskinesia, Drug-Induced / Q000378:metabolism*; D008297:Male; D008803:Mianserin / Q000378:metabolism*; D009570:Nitriles; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000378:metabolism*
D009570:Nitriles; D011985:Receptors, Serotonin; D008803:Mianserin; C008110:3,3'-iminodipropionitrile