The effect of the calcium antagonist gallopamil on arrhythmias and enzyme release in rat hearts with coronary ligation and reperfusion.
In intact rats, as well as in isolated perfused rat hearts, the calcium antagonist gallopamil reduced the severity of ischemic and reperfusion-induced arrhythmias. The effective doses, or concentrations, respectively, lay near the border to those producing atrioventricular block. The antiarrhythmic action was connected with a negative chronotropic effect, but was independent of the coronary vasodilating effect of the drug. Coronary occlusion, and especially reperfusion of the ischemic myocardium, led to the release of the enzyme creatine kinase (CK) from isolated hearts, and to the increase of the serum CK activity in intact rats. Gallopamil significantly reduced the reperfusion-induced enzyme release in isolated hearts. In intact rats the serum CK activities were higher in the presence of gallopamil, than without the drug. It is shown that gallopamil itself releases CK from the heart. This effect interferes with the action which gallopamil has on the enzyme release due to myocardial ischemia or reperfusion, respectively.
Bernauer
W
W
Department of Pharmacology, University of Freiburg, F.R.G.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000150:complications / Q000517:prevention & control*; D003402:Creatine Kinase / Q000378:metabolism; D003864:Depression, Chemical; D005711:Gallopamil / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D000889:Anti-Arrhythmia Agents; D005711:Gallopamil; D003402:Creatine Kinase