title: Recovery from hypopnea in preterm lambs: effects of breathing air or oxygen.
abstract: The aim of this study was to determine if resuscitation from hypopnea when breathing oxygen resulted in a slower recovery than that seen when breathing room air. Hyperoxia, in preterm human neonates and lambs, decreases minute ventilation (Vl), but no study has shown this effect during recovery from apnea or hypopnea, a common clinical setting. Thus, recovery from hypopnea was studied in eight unanesthesized preterm lambs, breathing spontaneously via an endotracheal tube placed into a tracheostomy. Hypopnea, defined here as a decrease in Vl from baseline greater than 50%, was induced by instillation of distilled water onto the larynx. After a baseline 30 sec when Vl, heart rate, and arterial blood gas were measured, a standard hypopnea stimulus was given over 30 sec. The lambs then breathed air or oxygen during a 2-min recovery period, which started with 15 sec of artificial ventilation. The degree of recovery at 2 min was less in the oxygen (O2) breathing group: Vl (ml/kg/min) = 381 +/- 27 in air and 270 +/- 18 in O2, P less than 0.01; pH = 7.38 +/- 0.005 in air and 7.34 +/- 0.008 in O2, P less than 0.01; arterial carbon dioxide tension (PaCO2, mmHg) = 45.0 +/- 1.3 in air and 49 +/- 1.3 in O2, P less than 0.01; base excess = 2.1 +/- 0.6 in air and 1.1 +/- 0.5 oxygen, P less than 0.01. By 2 min a return to baseline values of Vl, pH, and PaCO2 was noted only in the air breathing group, where the arterial oxygen tension also returned to normal.(ABSTRACT TRUNCATED AT 250 WORDS)
authors: Department of Pediatrics, University of Florida, College of Medicine, Gainesville 32610.
authors: A A
authors: AA
authors: Hutchison
mesh_terms: D000818:Animals; D001049:Apnea / Q000628:therapy*; D001272:Atmosphere; D001784:Blood Gas Analysis; D004195:Disease Models, Animal; D006339:Heart Rate; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000628:therapy*; D010100:Oxygen / Q000502:physiology*; D012119:Respiration; D012151:Resuscitation; D012756:Sheep
chemical_list: D010100:Oxygen