Reduction of 125I-angiotensin II binding sites in rat brain following monosodium glutamate treatment.
Adult Sprague-Dawley rats were pretreated with 6 g/kg of monosodium glutamate (MSG). After one month, specific binding of 125I-angiotensin II was measured in membrane preparations from the brain. A 40-45% decrease in the number of 125I-angiotensin II binding sites was observed in brain tissues containing circumventricular organs. No decrease in binding sites was observed in the thalamus/hypothalamus brain region, which resides totally within the blood-brain barrier. The results suggest that MSG can destroy angiotensin-sensitive neurons in circumventricular structures, which are located primarily outside the blood-brain barrier.
Rogulja
I
I
Department of Veterinary and Comparative Anatomy, Pharmacology, Physiology, Washington State University, Pullman.
Harding
J W
JW
Ritter
S
S
D000804:Angiotensin II / Q000493:pharmacokinetics*; D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005971:Glutamates / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012688:Septum Pellucidum / Q000187:drug effects / Q000378:metabolism; D012970:Sodium Glutamate / Q000494:pharmacology*; D013788:Thalamus / Q000187:drug effects / Q000378:metabolism
D005971:Glutamates; D000804:Angiotensin II; D012970:Sodium Glutamate