Calcium absorption and excretion in patients treated with verapamil.
1. The effect of verapamil on the intestinal absorption of calcium was studied using a single isotope technique. Serum calcium and urinary excretion of calcium in the urine were followed in nine patients during treatment with verapamil for 2 months. 2. A dose of 80-120 mg (three times daily) resulted in a significant reduction of systolic and diastolic blood pressure. 3. There was no change in the intestinal calcium absorption (alpha) expressed as the fraction of given activity absorbed per hour (alpha = 0.82 +/- 0.19 vs alpha = 0.83 +/- 0.25; +/- s.d., NS) or of the excretion of calcium in urine (Ca/creatinine ratio 0.35 +/- 0.20 vs 0.31 +/- 0.33; NS). 4. Serum calcium was not significantly different before and during treatment (2.43 mmol l-1 +/- 0.10 vs 2.47 mmol l-1 +/- 0.14; NS). 5. This study demonstrates that verapamil, at doses recommended for clinical use, does not seem to affect the intestinal absorption of calcium, the serum calcium concentration or the excretion of calcium in urine.
Sjödén
G
G
Department of Orthopaedic Surgery, Karolinska Institute, Huddinge University Hospital, Sweden.
Rosenqvist
M
M
Kriegholm
E
E
Haglund
K
K
D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D002118:Calcium / Q000493:pharmacokinetics*; D002132:Calcium Radioisotopes; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D014700:Verapamil / Q000009:adverse effects* / Q000627:therapeutic use
D002132:Calcium Radioisotopes; D014700:Verapamil; D002118:Calcium