Studies in laboratory animals to assess the safety of anti-inflammatory agents in acute porphyria.
The safety of various anti-inflammatory drugs in acute porphyria was assessed by examining their effect on rat hepatic haem synthesis. Azapropazone, chloroquine, and gold increased delta-aminolaevulinic acid (ALA) synthase activity, indicating that they are liable to precipitate porphyric crises. Aspirin, ibuprofen, indomethacin, ketoprofen, flurbiprofen, phenylbutazone, naproxen, prednisolone, and penicillamine did not increase ALA synthase activity and should be safe in porphyria. Though these animal studies can be used as a guide to prescribing in patients with acute porphyria, some caution is still required as species may vary in their response to inducing agents.
McColl
K E
KE
University Department of Medicine, Western Infirmary, Glasgow.
Thompson
G G
GG
Moore
M R
MR
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D010634:Phenobarbital / Q000633:toxicity; D011164:Porphyrias / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D000624:5-Aminolevulinate Synthetase; D010634:Phenobarbital