Renal effects of prednisolone in the chicken.
The effects of prednisolone on renal tubular transport of organic ions, urine flow and glomerular filtration rate were studied using the Sperber preparation in chickens. Low infusion rates of 1 and 5 nmole/min prednisolone slightly enhanced organic ion excretion. At higher infusion rates up to 1,000 nmol/min, no change in organic ion transport was observed. Urine flow and glomerular filtration rate increased at prednisolone infusion rates of 50 nmole/min and higher, independent of changes in renal blood flow.
Springate
J
J
Department of Pediatrics, Childrens Hospital, Buffalo, New York 14222.
Jeffery
D
D
Acara
M
M
D000818:Animals; D002645:Chickens; D004231:Diuresis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007444:Inulin; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D011239:Prednisolone / Q000494:pharmacology*; D013757:Tetraethylammonium Compounds; D010130:p-Aminohippuric Acid
D013757:Tetraethylammonium Compounds; D007444:Inulin; D011239:Prednisolone; D010130:p-Aminohippuric Acid