Effects of neuropeptide Y on left ventricular function in the conscious rabbit.
1. Changes in arterial pressure, heart rate and left ventricular contractility induced by intravenous injections of neuropeptide Y (NPY; 1-30 micrograms/kg) were studied in the conscious rabbit. 2. NPY has a brief pressor effect associated with a bradycardia, an increase in left ventricular end diastolic pressure, and a prolonged fall in peak left ventricular dP/dt (LVdP/dt). 3. The haemodynamic changes increase substantially with increasing doses up to 10 micrograms/kg. Beyond 10 micrograms/kg there are only slight effects on heart rate or peak LV dP/dt.
Minson
R B
RB
Department of Medicine, Flinders Medical Centre, South Australia.
McRitchie
R J
RJ
Chalmers
J P
JP
D000818:Animals; D001794:Blood Pressure; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009478:Neuropeptide Y / Q000494:pharmacology*; D011817:Rabbits; D016276:Ventricular Function
D009478:Neuropeptide Y