Ciprofloxacin concentrations in human aqueous humor following intravenous administration.
16 patients received an intravenous infusion of 200 mg ciprofloxacin 1, 2, 3 and 6 h, respectively, before cataract extraction. This dosage produced mean aqueous humor levels of 0.165 +/- 0.09 and 0.126 +/- 0.028 microgram/ml after 1 and 3 h, respectively. The mean serum levels were 1.760 +/- 0.873 and 0.854 +/- 0.283 microgram/ml after 1 and 3 h, respectively. These levels are above the minimum inhibitory concentration of ciprofloxacin for sensitive organisms.
Behrens-Baumann
W
W
Department of Ophthalmology, University of Göttingen, FRG.
Martell
J
J
D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011292:Premedication
D002939:Ciprofloxacin