[Intracranial and intraspinal hemorrhages in treatment with coumarin derivatives. Catamnesis of 63 cases between 1978 and 1986].
From 1978-1986, 63 patients (48-79 years) under coumarin derivatives had to be hospitalized neurosurgically because of intracranial or intraspinal bleedings. This corresponds to a twelvefold increased risk compared to the untreated people. The male/female ratio was 1.5. At the time of the bleeding there was no true indication for anticoagulation in at least 60% of the patients. 80% with coma on admission died. Only for 2/7 with an intraspinal hemorrhage the outcome was better than paraplegic. Women proved to have a better chance of survival. There is a need for more concise indications for chronic anticoagulation.
Moskopp
D
D
Neurochirurgische Universitätsklinik, Bonn.
Brassel
F
F
Ries
F
F
D000074:Acenocoumarol / Q000009:adverse effects; D000368:Aged; D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D003128:Coma / Q000139:chemically induced; D003374:Coumarins / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006408:Hematoma, Subdural / Q000139:chemically induced; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000139:chemically induced; D010644:Phenprocoumon / Q000009:adverse effects; D012307:Risk Factors; D013118:Spinal Cord Diseases / Q000139:chemically induced*
D003374:Coumarins; D000074:Acenocoumarol; D010644:Phenprocoumon
Intrakranielle und intraspinale Blutungen unter Behandlung mit Cumarinderivaten. Katamnese von 63 Fällen zwischen 1978 und 1986.