Placebo controlled comparison of midazolam, triazolam and diazepam as oral premedicants for outpatient anaesthesia.
Two short-acting benzodiazepines, midazolam 15 mg and triazolam 0.25 mg, were compared with diazepam 10 mg and placebo as oral premedicants in 120 patients presenting for minor urological surgery. Midazolam was found to produce the greatest degree of amnesia and sedation at the time of anaesthetic induction and triazolam was found to have the greatest degree of residual sedation at the time of discharge, four hours postoperatively. These effects are consistent with the greater potency and more rapid onset of action of midazolam at this dose compared with triazolam. The relative merits of the compounds as anxiolytics varied depending upon the observer, time and method of assessment. It was considered that the doses of midazolam and triazolam used were excessive for routine day case anaesthesia.
Forrest
P
P
Department of Anaesthesia, Wellington Clinical School, New Zealand.
Galletly
D C
DC
Yee
P
P
D000284:Administration, Oral; D000328:Adult; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D003975:Diazepam / Q000008:administration & dosage; D004311:Double-Blind Method; D006801:Humans; D008874:Midazolam / Q000008:administration & dosage; D008875:Middle Aged; D010147:Pain Measurement; D011229:Preanesthetic Medication; D011897:Random Allocation; D011795:Surveys and Questionnaires; D014229:Triazolam / Q000008:administration & dosage; D014570:Urologic Diseases / Q000601:surgery
D014229:Triazolam; D003975:Diazepam; D008874:Midazolam