X-ray diffraction study of cholesterol-phosphatidylserine mixtures.
Phosphatidylserine-cholesterol mixtures at a molar ratio of 2:1 were investigated by X-ray diffraction. Phase separation of cholesterol independent of temperature was detected, indicating limited solubility of cholesterol in phosphatidylserine bilayers. The second phase present, the mixed phospholipid-cholesterol phase, continued to undergo melting as determined by changes with temperature in both the small angle scattering profile and in the acyl chain packing.
Wachtel
E J
EJ
Department of Polymer Research, Weizmann Institute of Science, Rehovot, Israel.
Bach
D
D
D002784:Cholesterol; D008968:Molecular Conformation; D010718:Phosphatidylserines; D013816:Thermodynamics; D014961:X-Ray Diffraction
D010718:Phosphatidylserines; D002784:Cholesterol