Liver sinusoids and sinusoidal cells in patients with agnogenic myeloid metaplasia.
The origin of sinusoidal portal hypertension often remains unknown in patients with agnogenic myeloid metaplasia. Four consecutive patients with agnogenic myeloid metaplasia had liver biopsies examined under light and electron microscopy. Two of the four had obvious clinical portal hypertension; of these two, only one had portal vein thrombosis. All four cases showed sinusoidal infiltration by myeloid cells (from very mild to obvious) and an increased perisinusoidal collagen network. Under electron microscopy we observed (a) the collagenization of the Disse space, (b) myeloid cells in the lumen and the Disse space, (c) the transformation of perisinusoidal cells into transitional cells, and (d) fragments of basement membrane-like material. It is possible that all these abnormalities, and not only sinusoidal infiltration, contribute to increase vascular resistance, even when there is no clinical evidence of portal hypertension unrelated to vascular thrombosis.
Roux
D
D
Laboratoire des Interactions Cellulaires, Université de Bordeaux II, France.
Bioulac-Sage
P
P
Merlio
J P
JP
Lamouliatte
H
H
Quinton
A
A
Balabaud
C
C
D000368:Aged; D004729:Endothelium, Lymphatic / Q000648:ultrastructure; D004730:Endothelium, Vascular / Q000648:ultrastructure; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology*; D008099:Liver / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000150:complications / Q000473:pathology*