Antinephritic effect of prostaglandin E1 on serum sickness nephritis in rats (4). Enhanced clearance of macromolecules by the reticulo-endothelial system with prostaglandin E1.
Function of the reticulo-endothelial system (RES) was determined by the carbon clearance technique in rats. Rats in the previous phase of nephritis showed reduced function of the RES with circulating immune complexes compared with normal rats. Prostaglandin E1 (PGE1) at 1.0 mg/kg, s.c., resulted in significant recovery in the impaired RES activity of the rats in the previous state of nephritis. Dipyridamole, 400 mg/kg, p.o., slightly enhanced function of the RES, but 20 mg/kg azathioprine, p.o., did not. Thus, the enhanced RES activity with PGE1 can explain part of the antinephritic effect of PGE1.
Nagamatsu
T
T
Department of Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Suzuki
Y
Y
D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D001379:Azathioprine / Q000494:pharmacology; D002244:Carbon; D004176:Dipyridamole / Q000494:pharmacology; D008297:Male; D012157:Mononuclear Phagocyte System / Q000187:drug effects* / Q000503:physiopathology; D009393:Nephritis / Q000209:etiology / Q000503:physiopathology*; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012713:Serum Sickness / Q000150:complications
D000936:Antigen-Antibody Complex; D011458:Prostaglandins E; D004176:Dipyridamole; D002244:Carbon; D001379:Azathioprine