Inhibitory effects of 2-deoxytetronic acid, a putative endogenous satiety factor, on paraventricular neurons of rats, in vitro.
The endogenous sugar acid, 2-deoxytetronic acid (2-DTA) was investigated for its effects on activity of paraventricular nucleus (PVN) neurons in slice preparations from rats. 2-DTA dose-responsively inhibited the spontaneous activity of 23 of the 53 PVN neurons tested at concentrations of 10(-5) to 10(-2) M, and 2 were excited. The inhibitory responses were not due to osmotic changes by 2-DTA administration. The high concentration of 2-DTA needed to produce responses suggests that it acts as substrate for oxidative metabolism rather than as a neurotransmitter or neuromodulator in the suppression of feeding behavior.
Inenaga
K
K
Department of Physiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
Oomura
Y
Y
Shimizu
N
N
Kasai
M
M
Yamashita
H
H
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology; D006885:Hydroxybutyrates / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D001067:Appetite Depressants; D006885:Hydroxybutyrates; C041038:3,4-dihydroxybutanoic acid