Effect of azapropazone and allopurinol on myocardial infarct size in rats.
The effect of the xanthine oxidase inhibitor allopurinol and the non-steroidal antiinflammatory agent azapropazone on infarct size in rats, subjected to 48 h of occlusion of the left anterior descending coronary artery, were studied. Allopurinol (50 mg/kg i.p., twice daily from 24 h before to 48 h after LAD occlusion) and azapropazone (100 mg/kg i.p twice daily from 24 h before to 48 h after LAD occlusion) significantly reduced infarct size when compared to saline-treated rats. These data point towards involvement of xanthine oxidase derived free radicals in evolving myocardial infarction in rats; beneficial effect of azapropazone in this model may be related to the drug's ability to inhibit xanthine oxidase as well as various key neutrophil functions.
Montor
S G
SG
Division of Cardiovascular Diseases, E.I. du Pont de Nemours & Company Inc., Wilmington, DE 19898.
Thoolen
M J
MJ
Mackin
W M
WM
Timmermans
P B
PB
D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D001032:Apazone / Q000494:pharmacology*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D014227:Triazines / Q000494:pharmacology*
D014227:Triazines; D000493:Allopurinol; D001032:Apazone