A ferriprotoporphyrin IX-chloroquine complex promotes membrane phospholipid peroxidation. A possible mechanism for antimalarial action.
The effect of a ferriprotoporphyrin IX-chloroquine complex on phospholipid membranes was investigated on the basis of iron-induced lipid peroxidation using microsomal phospholipid liposomes. The ferriprotoporphyrin IX-chloroquine complex remarkably promoted peroxidative cleavage of unsaturated phospholipids in liposomes, compared with ferriprotoporphyrin IX alone. Neither the combination of protoporphyrin IX with chloroquine nor the combination of Fe3+-ADP with chloroquine promoted lipid peroxidation. DL-alpha-Tocopherol completely inhibited lipid peroxidation induced by the ferriprotoporphyrin IX-chloroquine complex.
Sugioka
Y
Y
Department of Parasitology, Gunma University School of Medicine, Maebashi, Japan.
Suzuki
M
M
Sugioka
K
K
Nakano
M
M
D002738:Chloroquine / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D005290:Ferric Compounds; D005296:Ferrous Compounds; D006418:Heme / Q000031:analogs & derivatives*; D006427:Hemin / Q000494:pharmacology*; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism*; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000378:metabolism*; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
D005227:Fatty Acids; D005290:Ferric Compounds; D005296:Ferrous Compounds; D008054:Lipid Peroxides; D010743:Phospholipids; D006418:Heme; D006427:Hemin; D002738:Chloroquine