Clomipramine-induced urinary dysfunction in an obsessive-compulsive adolescent.
Two episodes of urinary retention occurred in a 15-year-old male following administration of clomipramine given for obsessive-compulsive disorder. Improvement of behavioral symptoms along with side effects was clearly correlated with clomipramine dosage. Severity of side effects, and their resistance to bethanechol and to phenoxybenzamine, necessitated a complete withdrawal of clomipramine. This case demonstrates that clomipramine-induced urinary retention is not limited to older individuals. Possible involvement of noncholinergic and nonadrenergic mechanisms in this adverse drug reaction is suggested.
Hermesh
H
H
Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tiqva, Israel.
Aizenberg
D
D
Weizman
A
A
Lapidot
M
M
Munitz
H
H
D000293:Adolescent; D002997:Clomipramine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy*; D014555:Urination Disorders / Q000139:chemically induced*
D002997:Clomipramine