Demonstration that glycoprotein G is the attachment protein of respiratory syncytial virus.
Two monospecific rabbit antisera to the G glycoprotein, one induced with purified G and the second with a recombinant vaccinia virus containing the gene for G, inhibit the attachment of purified [35S]methionine-labelled Long strain of respiratory syncytial virus to monolayers of HeLa cells. Attachment was not inhibited by monospecific rabbit antisera to glycoprotein F induced with either purified F or with a recombinant vaccinia virus containing the gene for F.
Levine
S
S
Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan 48201.
Klaiber-Franco
R
R
Paradiso
P R
PR
D000911:Antibodies, Monoclonal; D004797:Enzyme-Linked Immunosorbent Assay; D006367:HeLa Cells / Q000382:microbiology; D006801:Humans; D007106:Immune Sera; D007700:Kinetics; D012136:Respiratory Syncytial Viruses / Q000378:metabolism*; D014759:Viral Envelope Proteins / Q000276:immunology / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D007106:Immune Sera; D014759:Viral Envelope Proteins