title: A phase II study of (2"R)-4'-0-tetrahydropyranyladriamycin (THP) in hematological malignancies.
abstract: A phase II study of new anthracycline, THP, was conducted in 46 patients with hematological malignancies in a cooperative study. THP was given intravenously either at a dose of 13-34 mg/m2 for 3-5 consecutive days or 35-50 mg/m2 at 3-4 week intervals. Of 21 patients with acute leukemia, complete response (CR) was observed in 3 patients and partial response (PR) in 4. Of 22 patients with malignant lymphoma, CR was observed in 2 and PR in 6. The predominant toxicity was myelosuppression. Leukopenia was noted in 73% of patients and thrombocytopenia in 14%. Anorexia, nausea and vomiting were observed in 49%, 26% and 23%, respectively. Alopecia and acute cardiac toxicities were mild and recovered quickly on discontinuation of THP. Thus, THP was found to be effective for acute leukemia and malignant lymphoma.
authors: Department of Internal Medicine, Branch Hospital, University of Nagoya, Japan.
authors: K
authors: K
authors: Yamada
authors: S
authors: S
authors: Shirakawa
authors: R
authors: R
authors: Ohno
authors: H
authors: H
authors: Yamada
authors: Y
authors: Y
authors: Hirota
authors: K
authors: K
authors: Ohara
authors: K
authors: K
authors: Yamagata
authors: M
authors: M
authors: Kobayashi
authors: M
authors: M
authors: Hirano
authors: Y
authors: Y
authors: Ikeda
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D004317:Doxorubicin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy*; D008223:Lymphoma / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D004317:Doxorubicin; C027260:pirarubicin