Synthesis and anticonvulsant properties of N-methylpyridyl derivatives of m- and p-bromophenylsuccinimides.
The reaction of m- or p-bromophenylsuccinic acids with 2-aminomethylpyridines yielded respective N-methylpyridylimides 1-8. Only compounds 1 and 6 show anticonvulsant activity in the pentetrazole and electric seizures tests, but their therapeutic index is inferior to that of ethosuximide and valproic acid.
Zejc
A
A
Department of Pharmaceutical Chemistry, Medical Academy, Kraków, Poland.
Obniska
J
J
Chojnacka-Wójcik
E
E
Tatarczyńska
E
E
Wiczyńska
B
B
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009422:Nervous System Diseases / Q000139:chemically induced; D004856:Postural Balance / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013056:Spectrophotometry, Ultraviolet; D013388:Succinimides / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000927:Anticonvulsants; D011725:Pyridines; D013388:Succinimides