[Proliferative activity of laryngeal cancer and possible morphologic prognostic factors].
Altogether 70 patients with histologically verified laryngeal cancer were studied. An analysis of the data obtained showed that tumor proliferative activity expressed by a labeling index (LI) correlated, to a certain extent, with various structural and functional properties of a tumor, e. g. LI showed correlation with a degree of differentiation of squamous cell carcinoma: in a nonkeratinizing type the mean LI was 8.2, in a keratinizing type 5.5. A noticeable immune response to a tumor was observed in most of the patients. However a stable tendency (p = 0.95) to a decrease in LI in marked lymphoid infiltration was revealed in nonkeratinizing squamous cell carcinoma only. There was no correlation between LI and a degree of vascularization. The preponderance of weak vascularization was noted in keratinizing squamous cell carcinoma. A decrease in LI in weak vascularization was also observed in this cancer type taking into account a degree of lymphoid infiltration. In clinical practice while designing a therapy one should bear in mind a variety of clinical, structural and biological features of a tumor.
Polonskaia
N Iu
NIu
Solov'eva
L P
LP
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008875:Middle Aged; D011379:Prognosis
Proliferativnaia aktivnsot' raka gortani i vozmozhnye morfologicheskiefaktory.