Dedifferentiated liposarcoma of the liver.
Among the rare occurrences of primary malignant mesenchymal tumors of the liver, the development of liposarcoma has been only theoretically listed--there is no proven example in the literature. This article documents a case of primary liposarcoma of the liver in a 30-year-old woman who presented with a huge intrahepatic tumor in the left lobe measuring 14 X 10 X 6 cm. It was composed of two distinct macroscopic and histologic features--the well-differentiated liposarcoma and the cellular, nonlipogenic pleomorphic sarcoma. The former was a mature, lipomatous tumor with various stages of lipoblasts. The latter was much more cellular, made up of pleomorphic cells admixed with a few areas of spindle cells with many mitotic figures, resembling a pleomorphic variant of malignant fibrous histiocytoma. Oil red O stain revealed multifocal, but a scanty amount, of fat-storing tumor cells in both compartments aside from large fat globules in the differentiated area. This is the first reported case of primary liposarcoma of the liver.
Kim
Y I
YI
Department of Pathology, College of Medicine, Seoul National University, Korea.
Yu
E S
ES
Lee
K W
KW
Park
E U
EU
Song
H G
HG
D000328:Adult; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D008080:Liposarcoma / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology*; D012509:Sarcoma / Q000473:pathology