Basic fibroblast growth factor is present in cultured human retinoblastoma cells.
Cultured human retinoblastoma cells express the basic fibroblast growth factor (bFGF) gene and they produce material similar, if not identical, to bFGF. The retinoblastoma-derived bFGF can stimulate the proliferation of capillary endothelial cells and this process is inhibited by anti-bFGF antibodies. It is conceivable that the retinoblastoma-derived bFGF contributes to the neovascularization of retinoblastomas.
Schweigerer
L
L
Cancer Research Institute M-1282, University of California Medical Center, San Francisco 94143.
Neufeld
G
G
Gospodarowicz
D
D
D002460:Cell Line; D004247:DNA; D005134:Eye Neoplasms / Q000378:metabolism* / Q000473:pathology; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006801:Humans; D009693:Nucleic Acid Hybridization; D012175:Retinoblastoma / Q000378:metabolism* / Q000473:pathology
D005346:Fibroblast Growth Factors; D004247:DNA