Neurophysiological changes induced by 5-HT reuptake inhibitors in rabbits.
The EEGraphic, behavioural and autonomic changes induced by the administration of some inhibitors of serotonin (5-HT) reuptake were evaluated in the rabbit. The drugs examined were: Alaproclate (Ala), Citalopram (Cit), Fluoxetine (Fluo), Fluvoxamine (Fluvo), Indalpine (Ind), Zimelidine (Zim). It seems that all these drugs would act exclusively or prevalently on 5-HT uptake. The changes of the parameters studied were not homogeneous. Some of these drugs (Cit, Zim) induced an EEGraphic and behavioural "arousal" pattern, others (Fluo, Fluvo) a "slow wave sleep" one, others (Ala, Ind) a biphasic one (alteration of the two above-mentioned patterns). The possible hypotheses subtending these data are discussed.
Bo
P
P
Istituto Neurologico C. Mondino, Università Degli Studi di Pavia, Italy.
Patrucco
M
M
Maurelli
M
M
Camana
C
C
Savoldi
F
F
D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D004562:Electrocardiography; D004569:Electroencephalography; D006339:Heart Rate / Q000187:drug effects; D011817:Rabbits; D012119:Respiration / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology*
D012702:Serotonin Antagonists