title: Role of sensory renal nerves in the development of spontaneous hypertension in rats.
abstract: In order to study the role of afferent renal nerves in the development of spontaneous hypertension, 3-4 weeks old uninephrectomized spontaneously hypertensive rats were deafferented selectively by a unilateral dorsal rhizotomy. Control rats were sham-operated. Until 10 weeks of age, systolic tail cuff blood pressures were identical in both groups. Although from 12 weeks on systolic blood pressure was slightly (10%) but significantly lower in deafferented rats, mean arterial pressures from an indwelling catheter were identical in deafferented and control rats. We therefore conclude that a selective destruction of afferent renal nerves does not delay or prevent the development of spontaneous hypertension in rats.
authors: Dept. of Pharmacology, University of Limburg, Maastricht, The Netherlands.
authors: B J
authors: BJ
authors: Janssen
authors: J J
authors: JJ
authors: Debets
authors: H A
authors: HA
authors: Struyker-Boudier
authors: J F
authors: JF
authors: Smits
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology; D003714:Denervation; D005260:Female; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D007262:Infusions, Intravenous; D007267:Injections; D007668:Kidney / Q000294:innervation*; D051381:Rats; D011918:Rats, Inbred SHR; D012677:Sensation / Q000502:physiology*
chemical_list: D001920:Bradykinin