[Isolation of chlorphenoxamine metabolites in human urine and their identification].
After the administration of chlorphenoxamine (2-[1-(4-chlorophenyl)-1-phenylethoxy]-N,N-dimethylethanamine++ +, Systral) (I) the following compounds have been detected in human urine. They were identified as chlorphenoxamine (I), N-demethyl-chlorphenoxamine (II), chlorphenoxamine-N-oxide (III), 1-(4-chlorophenyl)-l-phenylethanol (IV), 1-(4-chlorophenyl)-1-(4'-hydroxyphenyl)-ethanol (V), 1-(4-chlorophenyl)-1-(4'-hydroxyphenyl)-ethene (VI), 1-(4-chlorophenyl)-1-(4'-hydroxy-3'-methoxyphenyl)-ethanol (VII), 1-(4-chlorophenyl)-1-(4'-hydroxy-3'-methoxyphenyl)-ethene (VIII), 2-[1-(4-chlorophenyl)-1-(4'-hydroxyphenyl)-ethoxy]-N-methyl-ethanamine (IX) and 2-[1-(4-chlorophenyl)-1-(4'-hydroxy-3'-methoxyphenyl-ethoxy]- N-methylethanamine (X). The compounds IV, V, VI, VII, VIII, IX and X were also found to be excreted as conjugates. It cannot be excluded that the compounds VI and VIII are artefacts.
Goenechea
S
S
Institut für Rechtsmedizin, Universität Bonn.
Rücker
G
G
Brzezinka
H
H
Hoffmann
G
G
Neugebauer
M
M
Pyzik
T
T
D000328:Adult; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D005021:Ethylamines / Q000652:urine*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D005021:Ethylamines; C100100:chlorphenoxamine
Isolierung von Chlorphenoxamin-Metaboliten aus menschlichem Harn und ihre Identifizierung.