title: Transabdominal, a dominant mutant of the Bithorax Complex, produces a sexually dimorphic segmental transformation in Drosophila.
abstract: Transabdominal (Tab), a dominant mutation in the Bithorax Complex (BX-C) of Drosophila, creates a sexually dimorphic pattern of segmental transformation that has complete penetrance and expressivity. Specific regions within the notum of the second thoracic segment (T2) are transformed into abdominal-like cuticle; thus, the Tab/ + notum has sets of short stripes that are black in males and only bordered with black in females. Also, Tab/ + abdominal tergites, A1-A6, inclusive, have small patches of A7-like tergite cuticle. Tab is inseparable from an 89E/90D inversion, whose DNA breakpoint in 89E is at +188 kb in the infra-abdominal-8 (iab-8) region of the BX-C. When probed with a pupal cDNA from the iab-7 region, labeling above background was not detected in wild-type wing discs but was detected in, and confined to, the notal region of Tab/ + wing discs. The Tab/ + phenotype is assumed to result from cis-overexpression of iab-7 in localized regions of segments T2-A6, inclusive.
authors: Division of Biology, California Institute of Technology, Pasadena 91125.
authors: S E
authors: SE
authors: Celniker
authors: E B
authors: EB
authors: Lewis
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D004247:DNA / Q000235:genetics; D004330:Drosophila / Q000033:anatomy & histology / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D008297:Male; D009154:Mutation; D009693:Nucleic Acid Hybridization; D010641:Phenotype; D013909:Thorax
chemical_list: D004247:DNA