Sex difference of acetohexamide reduction in rat liver.
The acetohexamide reducing activity in hepatic 10,000 X g supernatant was significantly higher in male than in female rats. Evidence obtained in this study suggests that the microsomal carbonyl reductase may contribute to the sex difference in the reductive metabolism of acetohexamide in rats.
Imamura
Y
Y
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Kojima
Y
Y
Otagiri
M
M
D000092:Acetohexamide / Q000378:metabolism*; D000818:Animals; D003600:Cytosol / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D000092:Acetohexamide