Adaptation to hypoxia.
Many biochemical changes occur during acclimation to altitude. Some appear to be deleterious, but the increase in cytochrome-P 450 and the changes in the endoplasmic reticulum seem to be beneficial. The latter changes could reduce the capillary to oxidase gradient to compensate for the lower capillary oxygen tensions. The possibility of accelerating acclimation to hypoxia by using drugs which produce similar changes is being explored.
Longmuir
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Department of Biochemistry, North Carolina State University, Raleigh 27695-7622.
D000064:Acclimatization; D000531:Altitude; D001693:Biological Transport, Active; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D010088:Oxidoreductases / Q000378:metabolism; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption
D006454:Hemoglobins; D010088:Oxidoreductases; D010100:Oxygen