[Aminazine--highly effective inhibitor of tubulin polymerization].
Aminasine was found to repress tubulin polymerization into microtubules. This process is associated with the formation of anomalous structures--aggregates which contain, except tubulin, an increased amount of microtubule-associating proteins. The effect of aminasine on microtubules is specific, since it can be observed both in vitro and in vivo. Aminasine seems to be a helpful tool in studying the functions of tubulin and microtubules.
Androsova
L V
LV
Burbaeva
G Sh
GSh
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002746:Chlorpromazine / Q000494:pharmacology*; D003864:Depression, Chemical; D066298:In Vitro Techniques; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000187:drug effects* / Q000378:metabolism; D009391:Nephelometry and Turbidimetry; D011108:Polymers; D051381:Rats; D011919:Rats, Inbred Strains; D014404:Tubulin / Q000378:metabolism*
D008869:Microtubule-Associated Proteins; D011108:Polymers; D014404:Tubulin; D002746:Chlorpromazine
Aminazin--vysokoéffektivnyĭ ingibitor polimerizatsii tubulina.