Synthesis and antimycotic activity of some benzyloxyimino compounds.
Some benzyloxyimio compounds, related to oxiconazole and having a 1H-indole or 1H-benzimidazole moiety, have been synthesized and tested in vitro for their antimycotic activity against Candida tropicalis and C. albicans. The most active was showed to be 0-(2,4-dichlorobenzyl)-1-benzyl-5-nitro-1H-benzimidazole-2-carboxaldehyd e oxime (MIC: 25 micrograms/ml against both microorganisms). A structural feature important for the biological activity of the series appears to be presence of a benzimidazole nucleus substituted by an electron withdrawing group.
Garuti
L
L
Institute of Pharmaceutical Chemistry of the University, Bologna, Italy.
Giovanninetti
G
G
Ferranti
A
A
Chiarini
A
A
Bertocchi
G
G
Sabatino
P
P
Brigidi
P
P
D000935:Antifungal Agents / Q000138:chemical synthesis*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D001562:Benzimidazoles; D001593:Benzyl Compounds; D007211:Indoles