Influence of vehicle on antimicrobial efficiency of topical dosage forms of chloramphenicol.
Antimicrobial efficiency of chloramphenicol incorporated into ambiphilic emulsion bases was investigated, and it was shown that the efficiency was several times greater than the efficiency of a comercially available lipophilic dosage form. The efficiency was especially pronounced when the samples with a higher aqueous-phase content and of a lower viscosity were used. All ambiphilic preparations were stable when stored at 4 degrees C for 6 months, and when storage time was prolonged up to 1 year the most stable formulations were those which were prepared with a mixture of Tagat S and Tegin M.
Cajkovac
M
M
Faculty of Pharmacy and Biochemistry, University of Zagreb.
Kupinic
M
M
D001419:Bacteria / Q000187:drug effects*; D002701:Chloramphenicol / Q000008:administration & dosage / Q000494:pharmacology*; D004655:Emulsions; D008826:Microbial Sensitivity Tests; D014677:Pharmaceutical Vehicles
D004655:Emulsions; D014677:Pharmaceutical Vehicles; D002701:Chloramphenicol