[Reproductive kinetics of differentiating chondrocytes in normal states and in exposure to lead acetate].
Parameters of the mitotic cycle of chondrocytes in the skeletal extremities of the rat foetuses were estimated in various experiments with 3H-thymidine. Lead acetate entering the organism during the gestation period influenced the mitotic cycle duration, increasing it at the expense of a presynthetic phase. A change in the proliferation rates delayed the bones' growth and affected the morphological structure of the forming epiphyseal cartilage.
Zhitnikov
A Ia
AIa
Mazhuga
P M
PM
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D005260:Female; D005865:Gestational Age; D006132:Growth Plate / Q000166:cytology* / Q000187:drug effects / Q000196:embryology; D008938:Mitosis / Q000187:drug effects; D009942:Organometallic Compounds / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine; D014316:Tritium
D009942:Organometallic Compounds; D014316:Tritium; C008261:lead acetate; D013936:Thymidine
Kinetika reproduktsii differentsiruiushchikhsia khondrotsitov v norme i pri deĭstvii atsetata svintsa.