Propylene glycol pharmacokinetics and effects after intravenous infusion in humans.
Knowledge of the pharmacokinetics of propylene glycol (PG) is scarce, though it is used in a number of preparations for intravenous use. Although systemic toxicity appears to be uncommon, PG has been reported to cause lactic acidosis and other adverse effects. We describe a rapid gas chromatographic assay method for PG and the plasma pharmacokinetics after intravenous administration to six patients on nine occasions. The pharmacokinetics were nonlinear, based on a saturable clearance. The apparent first-order half-life was 2.3 +/- 0.7 h. There was no evidence of lactic acidosis, hemolysis, or increase in osmolality at 3-15 g/m2 PG infused over periods of 4 h.
Speth
P A
PA
Department of Haematology, St. Radboud University Hospital, Nijmegen, The Netherlands.
Vree
T B
TB
Neilen
N F
NF
de Mulder
P H
PH
Newell
D R
DR
Gore
M E
ME
de Pauw
B E
BE
D000328:Adult; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*
D011409:Propylene Glycols; D019946:Propylene Glycol