title: Selective catalysis of A.T base pair proton exchange in DNA complexes: imino proton NMR analysis.
abstract: Polyaromatic molecules with amino chain substituents, upon binding with DNA, selectively catalyze exchange of the A.T base pair protons with bulk water protons. The amine-catalyzed exchange is mediated by compounds which are A.T and G.C base sequence specific, intercalators, and outside binders. A mechanism for the selective exchange, involving transient opening and closing of individual A.T base pairs in the duplex, is discussed.
authors: Department of Chemistry, Georgia State University, Atlanta 30303.
authors: L
authors: L
authors: Strekowski
authors: R A
authors: RA
authors: Watson
authors: W D
authors: WD
authors: Wilson
mesh_terms: D000225:Adenine; D001482:Base Composition; D004247:DNA; D007097:Imines; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009690:Nucleic Acid Conformation; D013941:Thymine
chemical_list: D007097:Imines; D004247:DNA; D000225:Adenine; D013941:Thymine