A mathematical model of the development of drug resistance to cancer chemotherapy.
A mathematical model incorporating descriptions of tumour growth kinetics and the effects of cytotoxic chemotherapy on established tumours, is presented. It is shown how models of this kind may be used to investigate the potential of hypothetical chemotherapy strategies, and to identify general principles for successful treatment. The model is intended to be an aid to clinicians designing new chemotherapy programmes for diseases in which progress has been disappointing.
Birkhead
B G
BG
Department of Statistical Science, University College London.
Rankin
E M
EM
Gallivan
S
S
Dones
L
L
Rubens
R D
RD
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002453:Cell Cycle; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D006801:Humans; D008433:Mathematics; D008938:Mitosis; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D013997:Time Factors
D000970:Antineoplastic Agents