Effect of glucocorticoid deficiency after adrenalectomy on antitumor immunity.
We studied the effect of corticosterone after adrenalectomy on antitumor immunity in immunogenic tumors in mice. Antitumor immunity in the glucocorticoid deficient adrenalectomized mice (ADX mice) examined via comitant immunity and cytotoxic activity of spleen cells was compromised. Antitumor immunity was detected in ADX mice receiving sufficient supplementary doses of corticosterone. Loaded stress compromised the cytotoxic activity of the spleen cells in the ADX mice receiving adequate corticosterone, and the failure also contributed to the glucocorticoid deficiency because the activity was not affected by stress in the sham ADX mice. A matured effector cell activity was transferred to the glucocorticoid deficient ADX mice. We conclude that glucocorticoid deficiency compromises the antitumor immune response and that glucocorticoid might play an important role in the maturation of immunocompetent cells.
Hiramoto
Y
Y
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Sugimachi
K
K
D000315:Adrenalectomy / Q000009:adverse effects*; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology*; D004198:Disease Susceptibility; D005260:Female; D005354:Fibrosarcoma / Q000276:immunology*; D005938:Glucocorticoids / Q000172:deficiency*; D007111:Immunity, Cellular / Q000187:drug effects*; D007153:Immunologic Deficiency Syndromes / Q000209:etiology*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D013154:Spleen / Q000276:immunology / Q000473:pathology; D013312:Stress, Physiological / Q000150:complications
D005938:Glucocorticoids; D003345:Corticosterone