The Opitz hypertelorism-hypospadias syndrome. Further delineation of the spectrum of clinical findings.
In this paper we report three male patients with the Opitz hypertelorism-hypospadias syndrome. In addition to the typical morphological findings, signs of cerebral palsy related to dysmaturity and perinatal adaptation problems were present in two of them. This illustrates that this syndrome is a true multiple congenital anomaly/mental retardation MCA/MR syndrome with great variability in expression of clinical symptoms.
Dereymaeker
A M
AM
Department of Human Biology, U.Z. Gasthuisberg, Leuven, Belgium.
Fryns
J P
JP
Hoefnagels
M
M
Heremans
G
G
Marien
J
J
Van den Berghe
H
H
D000293:Adolescent; D001848:Bone Diseases, Developmental / Q000150:complications*; D002547:Cerebral Palsy / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006972:Hypertelorism / Q000150:complications*; D007021:Hypospadias / Q000150:complications*; D008297:Male