Resistance to the effects of thyroid hormone in children.
We have described three children with serum levels of TSH that are too high for the concomitant serum T4 level. Two of them meet the criteria for combined central and peripheral resistance to thyroid hormone. The third has long-standing central resistance to TSH suppression previously reported in congenital hypothyroidism. The recognition of this syndrome by physicians is important to avoid unnecessary and potentially dangerous treatment.
Rettig
K R
KR
University of South Alabama, Mobile 36617.
Sargeant
D T
DT
Kemp
S F
SF
D002648:Child; D002675:Child, Preschool; D003409:Congenital Hypothyroidism; D005260:Female; D006801:Humans; D006948:Hyperkinesis / Q000503:physiopathology; D006980:Hyperthyroidism / Q000175:diagnosis; D007037:Hypothyroidism / Q000175:diagnosis; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000473:pathology; D013963:Thyroid Hormones / Q000097:blood / Q000502:physiology*
D013963:Thyroid Hormones