Carbamazepine up-regulates the binding of [3H]PK 11195 to platelets of epileptic patients.
The maximal number of binding sites (Bmax) and the equilibrium dissociation constant (KD) values for [3H]PK 11195 binding were determined in the platelet membranes of epileptic patients before and after 4 weeks of carbamazepine (CBZ) treatment, as well as in healthy controls. There was a decrease of 17.1% in the Bmax value of patients before treatment as compared to the controls whereas an increase of 50.3% was observed in CBZ-treated patients as compared to their pretreatment values. The up-regulatory effect of CBZ on peripheral benzodiazepine receptors was not accompanied by alterations in KD values.
Weizman
A
A
Geha Psychiatric Hospital, Petah Tiqva, Israel.
Tanne
Z
Z
Karp
L
L
Martfeld
Y
Y
Tyano
S
S
Gavish
M
M
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002220:Carbamazepine / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004827:Epilepsy / Q000097:blood*; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000097:blood*
D007546:Isoquinolines; D002220:Carbamazepine; C037850:PK 11195