title: Dissociation and association rate constants changes following bilirubin binding affinity decreases.
abstract: The effect of sulfisoxazole, sodium salicylate, sodium cholate, urea and dimethyl sulfoxide on the kinetics of the bilirubin to human serum albumin at 24 degrees C and pH 7.40 was investigated. A marked decrease of the association constant was obtained. It was due mainly to that of the association rate constant, and might be an additional risk factor to the icteric newborn: when blood bilirubin increases, unbound bilirubin which cannot rapidly associate to albumin may reach a dangerous level, even when its equilibrium concentration is low.
authors: Laboratoire de Chimie Analytique, Faculté de Pharmacie, Université René-Descartes, Paris, France.
authors: B
authors: B
authors: Irollo
authors: B D
authors: BD
authors: Vu
authors: D N
authors: DN
authors: Dai
authors: J
authors: J
authors: Yonger
mesh_terms: D001663:Bilirubin / Q000097:blood*; D019826:Cholic Acid; D002793:Cholic Acids / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism*; D012980:Sodium Salicylate / Q000494:pharmacology; D013444:Sulfisoxazole / Q000494:pharmacology; D014508:Urea / Q000494:pharmacology
chemical_list: D002793:Cholic Acids; D012709:Serum Albumin; D013444:Sulfisoxazole; D014508:Urea; D019826:Cholic Acid; D001663:Bilirubin; D012980:Sodium Salicylate; D004121:Dimethyl Sulfoxide