[Effect of piracetam on the resistance of mice to hypoxic hypoxia 2 to 3 months following x-ray irradiation].
The resistance of mice to hypoxic hypoxia 3 months after their X-irradiation was evaluated with respect to such parameters as survival rate during the "ascent" to 11,000 m, life time at that altitude and brain succinic dehydrogenase (SDH) and lactate dehydrogenase (LDH) activities at an altitude of 7,000 m. Irradiated mice proved to be less resistant to hypoxic hypoxia. SDH activity increased to a greater extent in nonirradiated than in irradiated animals. Piracetam increased significantly the resistance to hypoxia of both irradiated and nonirradiated mice. SDH activity was stimulated by hypoxia in a greater degree in the piracetam-treated mice. The resistance to hypoxic hypoxia and SDH activation at an altitude of 7,000 m were found to be closely correlated. LDH activity remained essentially unchanged in any of the animal groups.
Popov
A V
AV
Bochenkov
A A
AA
Ivnitskiĭ
Iu Iu
IuIu
Volkovskiĭ
Iu V
IuV
D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D000860:Hypoxia / Q000150:complications / Q000503:physiopathology*; D008297:Male; D051379:Mice; D010889:Piracetam / Q000627:therapeutic use*; D011760:Pyrrolidinones / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000503:physiopathology*
D011760:Pyrrolidinones; D010889:Piracetam
Vliianie pirotsetama na ustoĭchivnost' mysheĭ k gipoksicheskoĭ gipoksii cherez 2-3 mes posle rentgenovskogo oblucheniia.