Radiation therapy for Graves' ophthalmopathy: a retrospective analysis.
A retrospective analysis of 29 patients with Graves' ophthalmopathy treated from 1973-1986 was undertaken to evaluate the use of radiation therapy (RT). Most patients presented with advanced disease; 20 had been treated with steroids and 8 had undergone prior surgery with orbital decompression. Post-RT evaluation was performed by the patients' Radiation Oncologist, Ophthalmologist, and Endocrinologist with a median follow-up period of 45 months. The overall assessment of the patients' disease was judged as improved with respect to the majority of signs and symptoms in 48%. Soft tissue changes were relieved in 78% and proptosis reduced in 52%. Ophthalmoplegia responded poorly and was improved in only 24%. After RT, 26/29 (90%) of patients have had no further steroid requirements. Thirteen patients underwent surgery for residual signs/symptoms post radiation therapy, indicating that combined modality may be necessary in many patients with advanced disease.
Palmer
D
D
Department of Radiation Oncology, Jonsson Comprehensive Cancer Center, Los Angeles, CA.
Greenberg
P
P
Cornell
P
P
Parker
R G
RG
D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000532:radiotherapy*; D005260:Female; D006111:Graves Disease / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009916:Orbital Diseases / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed