Contrasting effects of amphotericin B and the solvent sodium desoxycholate on peritoneal transport.
To distinguish amphotericin B effects on peritoneal transport from those of the solvent, sodium desoxycholate, dialyses in intact rabbits with either substance added intraperitoneally were compared to controls. Powered amphotericin B added to instilled dialysis fluid increased peritoneal ultrafiltration from 0.31 to 0.44 ml/kg/min (p less than 0.02), but did not affect mass transport (e.g. urea clearance changed from 0.86 to 1.04 ml/kg/min). In contrast, 10 mg of desoxycholate induced peritoneal irritation and raised clearances of urea (0.76-1.34 ml/kg/min), potassium, phosphate and dextrose, but did not affect ultrafiltration. Intraperitoneally, 1 mg/kg of desoxycholate changed clearances inconsistently, but lowered the ultrafiltration rate from 0.33 to 0.21 ml/kg/min. The dialysate-plasma dextrose gradient dissipated faster with 10 mg/kg of desoxycholate. Amphotericin B tended to raise ultrafiltration per osmotic gradient and mass transport of sodium. Selective increase in fluid flux results from amphotericin B, not its solvent.
J F
JF
Maher
P
P
Hirszel
E
E
Chakrabarti
R R
RR
Bennett
D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport; D003840:Deoxycholic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D007274:Injections, Intraperitoneal; D010529:Peritoneal Cavity / Q000187:drug effects / Q000378:metabolism*; D010530:Peritoneal Dialysis; D011188:Potassium / Q000378:metabolism; D011817:Rabbits; D012964:Sodium / Q000378:metabolism; D012997:Solvents; D014462:Ultrafiltration; D014508:Urea / Q000378:metabolism
D012997:Solvents; D003840:Deoxycholic Acid; D000666:Amphotericin B; D014508:Urea; D012964:Sodium; D005947:Glucose; D011188:Potassium