Identification of an arginine vasopressin-like diuretic hormone from Locusta migratoria.
We have identified two neuropeptides (F1 and F2) from suboesophageal and thoracic ganglia of Locusta migratoria, which we isolated earlier based on their immunological similarity to arginine vasopressin. The more abundant and hydrophilic factor, F1, has sequence Cys-Leu-Ile-Thr-Asn-Cys-Pro-Arg-Gly-NH2, but its biological role is unknown. The less abundant factor, F2, is an antiparallel dimer of F1, and functions as a diuretic hormone of this species. It appears to act through the intermediacy of cyclic AMP. The properties of the native neuropeptides were identical with those of samples synthesized from appropriately protected L-amino acids.
Laboratoire de Neuroendocrinologie, UA CNRS 1138, Université de Bordeaux I, Talence, France.
J P
JP
Proux
C A
CA
Miller
J P
JP
Li
R L
RL
Carney
A
A
Girardie
M
M
Delaage
D A
DA
Schooley
D000595:Amino Acid Sequence; D000818:Animals; D001127:Arginine Vasopressin / Q000032:analysis* / Q000494:pharmacology; D001681:Biological Assay; D002851:Chromatography, High Pressure Liquid; D004231:Diuresis / Q000187:drug effects; D005724:Ganglia / Q000032:analysis; D006110:Grasshoppers / Q000032:analysis*; D007301:Insect Hormones / Q000032:analysis* / Q000494:pharmacology; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000032:analysis; D011863:Radioimmunoassay
D007301:Insect Hormones; D046911:Macromolecular Substances; D009842:Oligopeptides; D001127:Arginine Vasopressin