Novel antibiotics napyradiomycins. Production, isolation, physico-chemical properties and biological activity.
Novel antibacterial antibiotics napyradiomycins A, B1, B2, B3, C1 and C2 have been isolated from the culture broth of Chainia rubra MG802-AF1. In this paper, taxonomy of the producer, and production, isolation, physico-chemical properties and biological activities of napyradiomycins are reported. They contain the naphtopyran chromophore and halogens, and inhibit the growth of Gram-positive bacteria including drug-resistant strains.
K
K
Shiomi
H
H
Iinuma
M
M
Hamada
H
H
Naganawa
M
M
Manabe
C
C
Matsuki
T
T
Takeuchi
H
H
Umezawa
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000145:classification / Q000378:metabolism
D000900:Anti-Bacterial Agents