Acquired factor XI inhibitors in congenitally deficient patients.
Four factor XI (F XI)-deficient patients are described, all of whom formed circulating anticoagulants against F X1. In the three most severely affected patients (F XI 0%-6% activity), the anticoagulant appeared to have been stimulated by plasma infusion. However, in the milder case (25% F XI activity), no infusion had been documented. The findings in these cases emphasize the diversity of F XI inhibitors in congenitally deficient patients. Awareness of the potential development of these inhibitors will be helpful in both daily management and perioperative care of such patients.
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
S F
SF
Schnall
T P
TP
Duffy
L P
LP
Clyne
D000328:Adult; D000368:Aged; D005172:Factor XI / Q000037:antagonists & inhibitors*; D005173:Factor XI Deficiency / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D010375:Pedigree; D011517:Prothrombin Time
D005172:Factor XI