Complexes of polyriboguanylate with modified polyribocytidylate.
It was established minimal length of continuous poly(C) sequence of poly(G).poly(C) complex required for effective interferon induction by investigation poly(G).poly(C,A) with different molar ratios of C:A varying from 10:1 to 90:1. The minimum length of the double-stranded sequence of the macromolecule complex poly(G).poly(C) is equal to at least 90-100 nucleotides. The effect of 5-halogen-polyribocytidilates on the properties of the complexes has been also investigated.
Institute of Macromolecular Compounds, Academy of Sciences of the USSR, Leningrad.
N S
NS
Sidorova
E M
EM
Kogan
N G
NG
Naumovich
D000244:Adenosine Diphosphate; D003565:Cytidine Diphosphate; D011061:Poly A; D011066:Poly C / Q000138:chemical synthesis*; D011068:Poly G / Q000138:chemical synthesis*; D011131:Polyribonucleotides / Q000138:chemical synthesis*
D011131:Polyribonucleotides; D011061:Poly A; D011068:Poly G; C008961:poly G-poly C; C023794:poly(A-C); D011066:Poly C; D000244:Adenosine Diphosphate; D003565:Cytidine Diphosphate