Derivatives of 1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octan-5-trans-ol with antiarrhythmic and other activities. VIII.
The synthesis of some alkyl, aryl thioureas and aryl ureas starting from 5-trans-(3-aminopropoxy)-1,2,3,3-tetramethyl-2-azabicyclo[2.2.2]octane is described. Some thioureas showed a remarkable antiarrhythmic activity besides a weak hypotensive effect in rats and, like some ureas, infiltration anesthesia in mice.
Istituto di Scienze Farmaceutiche, Università di Genova, Italy.
M
M
Longobardi
A
A
Bargagna
P
P
Schenone
D
D
De Santis
M
M
Angrisani
E
E
Marmo
D000779:Anesthetics, Local / Q000138:chemical synthesis; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis*; D001794:Blood Pressure / Q000187:drug effects; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D006339:Heart Rate / Q000187:drug effects; D051379:Mice; D051381:Rats
D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds