Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution.
An aminopolyether mediated synthesis of fluorine-18 (18F) 2-fluoro-2-deoxy-D-glucose (FDG) has been developed. The nucleophilic fluorination with accelerator-produced [18F]fluoride works at the no-carrier-added level and gives epimerically pure 2-18FDG with an uncorrected radiochemical yield of a maximum 50% in a synthesis time of approximately 50 min from EOB.
Hamacher
K
K
Coenen
H H
HH
Stöcklin
G
G
D055598:Chemical Phenomena; D002621:Chemistry; D003837:Deoxy Sugars / Q000138:chemical synthesis*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D004987:Ethers; D005461:Fluorine; D019788:Fluorodeoxyglucose F18; D007553:Isotope Labeling; D011108:Polymers; D011868:Radioisotopes; D013237:Stereoisomerism
D003837:Deoxy Sugars; D004987:Ethers; D011108:Polymers; D011868:Radioisotopes; D019788:Fluorodeoxyglucose F18; D005461:Fluorine; D003847:Deoxyglucose