In vitro activity of ampicillin plus sulbactam against anaerobes compared to ampicillin and cefoxitin.
The antimicrobial susceptibility of 195 recent clinical isolates of anaerobic bacteria was studied to ampicillin alone, ampicillin + 1 mg/l sulbactam, ampicillin + 5 mg/l sulbactam, and cefoxitin by means of agar dilution tests. The ampicillin-sulbactam combinations were the most effective drugs against species of the Bacteroides fragilis group, the MIC90 of ampicillin + 5 mg/l sulbactam for B. fragilis being less than 1 mg/l, compared to 256 mg/l of ampicillin, 4 mg/l of ampicillin + 1 mg/l sulbactam, and 8 mg/l of cefoxitin. No significant difference between ampicillin alone and in combination with sulbactam was observed against gram-positive anaerobic rods, Peptococcus spp. and Peptostreptococcus spp. with MIC's less than 2 mg/l.
Heizmann
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W
Abteilung für Medizinische Mikrobiologie, Hygiene-Institut der Universität, Tübingen.
Heilmann
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Werner
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H
D000667:Ampicillin / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001439:Bacteroides / Q000187:drug effects; D002440:Cefoxitin / Q000494:pharmacology*; D003013:Clostridium / Q000187:drug effects; D004347:Drug Interactions; D006801:Humans; D008826:Microbial Sensitivity Tests; D010459:Peptococcaceae / Q000187:drug effects; D011425:Propionibacterium acnes / Q000187:drug effects; D013407:Sulbactam / Q000494:pharmacology*
D002440:Cefoxitin; D000667:Ampicillin; D013407:Sulbactam