Problems of uridine protection.
Various routes to synthesize 5'-O-dimethoxytrityl-O4-p-nitrophenylethyl- 2'-O-p-nitrophenylethylsulfonyluridine (7) as a useful intermediate in oligoribonucleotide synthesis have been investigated. The direct sulfonylation of 5'-dimethoxytrityl-O4-p-nitrophenylethyluridine (4) gave the best results despite the fact that 7 is formed in almost equal amounts with its 3'-NPES isomer (8) and the 2',3'-di-O-NPES derivative (6).
Farkas
S
S
Fakultät für Chemie, Universität Konstanz, FRG.
Pfleiderer
W
W
D007202:Indicators and Reagents; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D014320:Triphenylmethyl Compounds / Q000138:chemical synthesis*; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D007202:Indicators and Reagents; D009843:Oligoribonucleotides; D014320:Triphenylmethyl Compounds; C054404:5'-O-dimethoxytrityl-O(4)-4-nitrophenylethyl-2'-O-4-nitrophenylethylsulfonyluridine; D014529:Uridine