Rearrangements of chromosome region 12q13----q15 in pleomorphic adenomas of the human salivary gland (PSA).
Nine of 40 pleomorphic salivary gland adenomas (PSAs) showed clonal aberrations of chromosome 12, with a breakpoint at 12q13----q15. The cytogenetic findings in these cases and those of nine additional cases reported in the literature suggest that this type of aberration is a primary change directly involved in the genesis of PSA.
Centre of Human Genetics and Genetic Counselling, University of Bremen, Federal Republic of Germany.
J
J
Bullerdiek
S
S
Bartnitzke
M
M
Weinberg
R
R
Chilla
J
J
Haubrich
W
W
Schloot
D000236:Adenoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic