Potentiation of the adverse effects of intravenous terbutaline by oral theophylline.
We have studied the influence of therapeutic plasma concentrations of theophylline on some of the unwanted responses to intravenous terbutaline in normal subjects. There was a significantly greater fall in serum potassium and rise in plasma glucose, pulse rate and systolic blood pressure in response to an intravenous infusion of terbutaline when theophylline was present compared with when terbutaline was given alone. These drugs are commonly used together in the treatment of acute asthma and potentiation of side effects may be hazardous. We suggest monitoring of the serum potassium when these drugs are used together during acute exacerbations of asthma.
S R
SR
Smith
M J
MJ
Kendall
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D004341:Drug Evaluation; D004357:Drug Synergism; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced*; D007275:Injections, Intravenous; D008297:Male; D013726:Terbutaline / Q000009:adverse effects*; D013806:Theophylline / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood
D001786:Blood Glucose; D013806:Theophylline; D013726:Terbutaline