Modification of cisplatin toxicity by antioxidants.
cis-Diamminedichloroplatinum II (cisplatin) is a potent anticancer chemotherapeutic agent. The major limitation in its use is nephrotoxicity, caused by an unknown mechanism. Injection of cisplatin into rats caused a decrease in body weight and an increase in blood urea nitrogen (BUN). These effects were modified by giving a radical scavenger, alpha-tocopherol, before the cisplatin injection. N-N'-diphenyl-p-phenylenediamine, another powerful radical scavenger, also attenuated the increase in BUN induced by cisplatin. These results suggest that the toxic effects of cisplatin may be related to free radical induced damage.
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Sugihara
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Gemba
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000633:toxicity*; D005609:Free Radicals; D007668:Kidney / Q000187:drug effects; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D010655:Phenylenediamines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D010655:Phenylenediamines; D014810:Vitamin E; C004845:N,N'-diphenyl-4-phenylenediamine; D002945:Cisplatin