Studies on meperidine-induced catalepsy in mice.
Anticataleptic effect of different pharmacological agents was studied against meperidine-induced (50 mg/kg i.p.) catalepsy in mice. MAO (A and B) inhibitors, alpha 2-agonists in addition to dopaminergic, GABAergic and serotoninergic agents, were found to be effective in attenuating the cataleptic symptoms. However, naloxone, an opiate antagonist, failed to reverse meperidine-induced akinesia and rigidity. Clorgyline, a specific MAO-A inhibitor, was found to be more potent than the MAO-B inhibitor selegiline.
Aley
K O
KO
Department of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Kulkarni
S K
SK
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced*; D005260:Female; D008297:Male; D008614:Meperidine / Q000494:pharmacology*; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000187:drug effects
D008996:Monoamine Oxidase Inhibitors; D011954:Receptors, Dopamine; D009270:Naloxone; D008614:Meperidine