Mortality from systemic lupus erythematosus in England and Wales, 1974-1983.
Mortality rates from systemic lupus erythematosus (SLE) in England and Wales were estimated from Office of Population Censuses and Surveys data from 1974 to 1983, by age and sex. Age-specific average annual mortality rates showed unimodal distributions for both sexes with maximal death rates in the 65-74-year age groups. The overall age-adjusted mortality rate for females was about four times that in males, 3.94 versus 1.02 per million person-years, respectively. Examination of individual age-specific rates showed an early sharp rise in females producing female-to-male ratios which exceeded 10 in the 25-34-year age group. Age-adjusted annual mortality rates in females significantly declined during the 10-year interval studied from 4.47 to 2.99 per million person-years (p = 0.0083). These patterns of mortality from SLE observed in England and Wales are comparable to those reported among Caucasians in the United States during a similar time period.
Department of Community Medicine, United Medical School of Guy's Hospital, London.
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Hochberg
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004739:England; D005260:Female; D006801:Humans; D007223:Infant; D008180:Lupus Erythematosus, Systemic / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014852:Wales