Extracorporeal cephalic blood autoperfusion method in the rat. Hemorrheological evaluation and proposed pharmacological uses.
We propose a constant cephalic blood perfusion method especially suitable to the rat. Cerebrovascular blood pressure is artificially regulated by an extracorporeal circuit with a perfusion pump and a Starling valve. A hemorrheological evaluation allows one to demonstrate an extracorporeal circuit that shows a growing pathological evolution, which can be purposely accelerated by iterative ischemic episodes. This method can be used (as shown by some examples) as a model for cerebrovascular failure or to study deleterious effects of the extracorporeal circuit.
Durussel
J J
JJ
Claperon
N
N
Dufaux
J
J
Quemada
D
D
Rossignol
P
P
D000818:Animals; D001921:Brain; D002545:Brain Ischemia / Q000188:drug therapy*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004195:Disease Models, Animal; D005112:Extracorporeal Circulation; D006706:Homeostasis / Q000187:drug effects; D009118:Muscimol / Q000494:pharmacology; D010477:Perfusion / Q000379:methods*; D010952:Plasma Substitutes; D051381:Rats; D012212:Rheology
D010952:Plasma Substitutes; D009118:Muscimol