Synaptic plasticity to estrogen in the lateral septum of the adult male and female rats.
There is no sex difference in the number of axodendritic synapses in the lateral septum of adult rats. However, the treatment of adult females with estradiol (E2) for 4 weeks increases significantly the number of synapses, whereas E2 treatment fails to increase the synaptic number in males, suggesting a possible sexually dimorphic synaptic response to estrogen.
Department of Anatomy, Juntendo University School of Medicine, Tokyo, Japan.
M
M
Miyakawa
Y
Y
Arai
D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012688:Septum Pellucidum / Q000187:drug effects*; D012737:Sex Factors; D013569:Synapses / Q000187:drug effects / Q000502:physiology*
D004958:Estradiol