The effect of meperidine on the guinea pig extrahepatic biliary tract.
The effect of meperidine on the mechanical activity of isolated guinea pig common bile duct (CBD) and gallbladder was studied in vitro. The effect was found to consist of inhibitory and excitatory phases. The inhibitory phase, characterized by a decrease in the response of the CBD and gallbladder to carbachol and electrical stimulation, was seen with concentrations of 10(-6) M or higher. The excitatory phase, seen at high concentrations of meperidine (5 X 10(-5)-10(-4) M), involved an increase in spontaneous contractions of CBD and in the tone of the gallbladder. Neither effect of meperidine was affected by 0.5 X 10(-5) M naloxone. These data indicate that meperidine acts on the biliary tract by a mechanism different from that associated with the effect of morphine.
Department of Surgery, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.
M
M
Goldberg
E
E
Vatashsky
Y
Y
Haskel
D
D
Seror
S
S
Nissan
M
M
Hanani
D000818:Animals; D002217:Carbachol / Q000037:antagonists & inhibitors; D003135:Common Bile Duct / Q000187:drug effects* / Q000502:physiology; D004594:Electrophysiology; D005260:Female; D005704:Gallbladder / Q000187:drug effects* / Q000502:physiology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D008614:Meperidine / Q000494:pharmacology*
D002217:Carbachol; D008614:Meperidine