T-2 toxin effects on the serum amyloid P-component (SAP) response of Listeria monocytogenes- and Salmonella typhimurium-infected mice.
T-2 mycotoxin, given to mice 4 days prior to an intraperitoneal inoculation with Listeria monocytogenes EGD, increases the acute phase response as determined by measurements of serum amyloid protein-P (SAP), and decreases the severity of the infection. Conversely, when T-2 toxin is given simultaneously with L. monocytogenes the mice become more susceptible to the infection, and the SAP levels attained are diminished relative to the non-toxin-treated Listeria-infected controls. T-2 toxin given 4 days prior to intraperitoneal inoculation with Salmonella typhimurium had no effect on either the resultant infection or SAP levels. These results indicate that T-2 toxin modulates the acute phase response to infection, and are consistent with an in vivo role for SAP as a nonspecific host resistance factor.
Veterinary Toxicology and Entomology Research Laboratory, United States Department of Agriculture, College Station, TX 77841.
R L
RL
Ziprin
P S
PS
Holt
R F
RF
Mortensen
D000818:Animals; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005260:Female; D008088:Listeriosis / Q000097:blood*; D051379:Mice; D008813:Mice, Inbred ICR; D012481:Salmonella Infections, Animal / Q000097:blood*; D000683:Serum Amyloid P-Component / Q000097:blood*; D012717:Sesquiterpenes / Q000633:toxicity*; D013605:T-2 Toxin / Q000633:toxicity*
D000683:Serum Amyloid P-Component; D012717:Sesquiterpenes; D013605:T-2 Toxin; D004121:Dimethyl Sulfoxide