Pharmacokinetics of a syrup formulation of amoxycillin-potassium clavulanate in children.
The pharmacokinetics of a syrup formulation consisting of four parts of amoxycillin and one part of potassium clavulanate (Augmentin) were studied in 11 paediatric patients, 3 to 14 years of age. Single oral doses of 25 mg of Augmentin per kg body weight (20 mg of amoxycillin per kg plus 5 mg of potassium clavulanate per kg, i.e. 1 mg of the syrup per kg) were administered on an empty stomach, and were well accepted and tolerated. Mean peak plasma concentrations 60-90 min after dosing were 7.2 mg/l for amoxycillin and 2.0 mg/l for clavulanic acid. Mean terminal phase plasma half-lives were 1.4 and 1.0 h, respectively. It is concluded that 25-mg/kg doses of this syrup formulation of Augmentin administered three times daily should be adequate therapy for various childhood bacterial infections.
U B
UB
Schaad
P A
PA
Casey
A T
AT
Ravenscroft
D000293:Adolescent; D000658:Amoxicillin / Q000097:blood / Q000378:metabolism* / Q000652:urine; D019980:Amoxicillin-Potassium Clavulanate Combination; D002648:Child; D002675:Child, Preschool; D002969:Clavulanic Acids / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004338:Drug Combinations / Q000097:blood / Q000378:metabolism / Q000652:urine; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D012996:Solutions
D002969:Clavulanic Acids; D004338:Drug Combinations; D012996:Solutions; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin