Arylsulfatase B synthesis and clearance in inbred mouse strains.
Arylsulfatase B activity levels were approximately 2-3-fold higher in adult C57BL/6J liver and kidney compared to corresponding tissues from A/J inbred mice. In vivo incorporation of tritiated leucine into C57BL/6J hepatic arylsulfatase B reached a maximum approximately 15 h after injection. The label was cleared from C57BL/6J arylsulfatase B with an apparent half-life of 36 h. The relative rates of synthesis of C57BL/6J and A/J arylsulfatase B were similar; however, the A/J enzyme was cleared more rapidly from liver tissue. C57BL/6J kidney arylsulfatase B appeared to be synthesized at a 2-3-fold higher rate than the corresponding A/J enzyme. These trends suggest genetic regulation of arylsulfatase B is effected through different means in liver and kidney from adult mice of these two inbred strains.
Department of Anatomical Sciences, University of Illinois, Urbana 61801.
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Daniel
D000818:Animals; D002803:Chondro-4-Sulfatase / Q000235:genetics / Q000378:metabolism*; D005260:Female; D014644:Genetic Variation; D007668:Kidney / Q000201:enzymology*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008657:Metabolic Clearance Rate; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D013429:Sulfatases / Q000378:metabolism*
D013429:Sulfatases; D002803:Chondro-4-Sulfatase