Interacting effects of zinc and cadmium on the cadmium distribution in the mouse.
Effects of zinc (Zn) on cadmium (Cd) distribution in the mouse body were investigated after intranasal administration. The amounts of Cd (2 x 10(-6) M/0.02 ml) reaching respiratory organs increased as the ip dose of pentobarbital increased. Administration of Zn with Cd (2 x 10(-6) M Zn + 2 x 10(-6) M Cd /0.02 ml) further increased the Cd amounts reaching respiratory organs and increased mouse mortality. A single administration of Cd increased Cd levels in blood, liver, kidney and respiratory organs. High levels of Cd were maintained for at least 90 days in these organs after single administrations of Cd. The administration of Cd plus Zn further increased the Cd content in these organs during 0-60 min after administration. However, simultaneous administration of Zn with Cd inhibited prolonged Cd accumulation in kidney and liver. These results suggest that intranasally administered Zn (2 x 10(-6) M) has dual effects on Cd movement. Zn further increases the Cd levels in the lung and mouse mortality increases. On the contrary, Zn inhibits prolonged Cd accumulation in mice and decreases the chronic toxicity in mice that survive the acute phase.
Department of Veterinary Public Health, Nippon Veterinary and Zootechnical College, Tokyo, Japan.
F
F
Ueda
H
H
Seki
H
H
Fujiwara
K
K
Ebara
S
S
Minomiya
Y
Y
Shimaki
D000281:Administration, Intranasal; D000818:Animals; D002104:Cadmium / Q000493:pharmacokinetics* / Q000633:toxicity; D004064:Digestive System / Q000378:metabolism; D004347:Drug Interactions; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012137:Respiratory System / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology*
D002104:Cadmium; D015032:Zinc