Urocanic acid may not be the photoreceptor for UV-induced suppression of contact hypersensitivity.
We have tested the hypothesis that urocanic acid is the photoreceptor molecule for ultraviolet radiation-induced systemic suppression of contact hypersensitivity in the mouse. Almost complete removal of urocanic acid by tape-stripping of exposed skin was not associated with abrogation of immune suppression. This finding makes it unlikely that urocanic acid is the chromophore.
W L
WL
Morison
S P
SP
Kelley
D000818:Animals; D003877:Dermatitis, Contact / Q000276:immunology*; D005260:Female; D007093:Imidazoles / Q000032:analysis*; D051379:Mice; D010786:Photoreceptor Cells / Q000032:analysis*; D012867:Skin / Q000032:analysis / Q000528:radiation effects*; D014466:Ultraviolet Rays; D014560:Urocanic Acid / Q000032:analysis*
D007093:Imidazoles; D014560:Urocanic Acid