Early polyamine treatment accelerates regeneration of rat sympathetic neurons.
After injury of their axons, damaged neurons shift their metabolic activity into a reparative mode aimed at survival and regeneration or, alternatively, they undergo degeneration and die. Previous reports have shown that at the initial stages of the response to axonal injury, polyamines are essential for neuronal survival and can accelerate functional recovery. In this study we examined the ability of exogenous polyamines to accelerate regeneration following crush of the pre- or postganglionic sympathetic nerves of the superior cervical ganglion in adult rats. We found that early treatment with polyamines after pre- or postganglionic nerve crush, accelerated the reappearance of choline acetyltransferase activity in the superior cervical ganglion, and of [3H]norepinephrine uptake in the iris, respectively. Functional recovery from eyelid ptosis was also accelerated. We conclude that treatment with polyamines can enhance regeneration of peripheral sympathetic neurons.
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M
Dornay
V H
VH
Gilad
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I
Shiler
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GM
Gilad
D000818:Animals; D001763:Blepharoptosis / Q000188:drug therapy; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D005728:Ganglia, Sympathetic / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D007498:Iris / Q000378:metabolism; D008297:Male; D009409:Nerve Crush; D009416:Nerve Regeneration / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D010870:Pineal Gland / Q000378:metabolism; D011073:Polyamines / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013096:Spermine / Q000627:therapeutic use; D013562:Sympathectomy
D011073:Polyamines; D013096:Spermine; D002795:Choline O-Acetyltransferase; D009638:Norepinephrine