Distribution of intact and Fab2(1) fragments of anti-human chorionic gonadotrophin antibodies in nude mice bearing human choriocarcinoma xenografts.
A direct comparative study of the distribution of intact and Fab2(1) fragments of mouse monoclonal anti-human chorionic gonadotrophin antibody, W14A, in nude mice bearing a human choriocarcinoma xenograft, indicates that the tumour:blood ratio is generally improved with fragments. Some parameters which may determine the distribution are outlined.
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Searle
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Adam
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Boden
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis*; D002822:Choriocarcinoma / Q000276:immunology*; D006063:Chorionic Gonadotropin / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007140:Immunoglobulin Fab Fragments / Q000032:analysis*; D007457:Iodine Radioisotopes; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011247:Pregnancy; D014183:Transplantation, Heterologous; D014594:Uterine Neoplasms / Q000276:immunology*
D000911:Antibodies, Monoclonal; D006063:Chorionic Gonadotropin; D007106:Immune Sera; D007140:Immunoglobulin Fab Fragments; D007457:Iodine Radioisotopes