Spin-lattice relaxation (T1) times of cerebral white matter in multiple sclerosis.
Magnetic resonance imaging was used to evaluate the cerebral white matter of three subject groups: (1) 22 patients with known multiple sclerosis (MS) (11 with disease of shorter duration (0-5 years) and 11 with disease of longer duration (greater than 5 years]; (2) 9 patients with suspected MS; and (3) 12 normal volunteers. Transverse spin-echo (SE) 30/500 and 120/1000 radiofrequency pulse sequences were used for anatomic localization and plaque identification, respectively, while combined spin echo-inversion recovery was used for T1 determination. T1 values were calculated for grossly normal cerebral white matter in the frontal, parietal, and occipital lobes of normal volunteers and MS patients, and for plaques in MS patients. When compared with normals, the T1 values of plaque-free areas from definite MS patients (shorter and longer duration disease groups combined) were significantly longer in the frontal lobe (MS = 374 +/- 34 ms, Normal = 352 +/- 39 ms, P less than 0.05) and in the occipital lobe (MS = 414 +/- 37, Normal = 378 +/- 40, P less than 0.02). Although the T1 values of the shorter duration MS group were longer than those of normals, the difference was not statistically significant. Thus, the significant difference between the definite MS group (both shorter and longer duration) is more heavily weighted by the longer duration MS group. T1 values in patients with suspected MS without plaques were not significantly different from those of normals. In diagnosed MS patients, T1 values of plaques were significantly longer than T1 values of corresponding normal areas (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Lacomis
D
D
Osbakken
M
M
Gross
G
G
D000328:Adult; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis*; D013997:Time Factors