[Experimental study of the use of colchicine in alcoholic liver diseases].
Rats kept on a standard diet were subdivided into several experimental groups: group 1, control; group 2, animals receiving ethyl alcohol for 10 days; group 3, animals receiving ethyl alcohol for 3 months; group 4, animals receiving colchicine; group 5, animals receiving alcohol in combination with colchicine; group 6, animals receiving alcohol in combination with carbon tetrachloride (CCl4); and group 7, animals receiving alcohol in combination with CCl4 and colchicine. Electron microscopy of the rat liver has shown that colchicine inhibited significantly the onset of hepatic fibrosis and degenerative changes in hepatocyte organells induced by hepatotoxins (alcohol alone or alcohol in combination with CCl4). Colchicine also inhibited monooxygenase activity in the liver homogenate of experimental rats. Possible mechanisms of hepatoprotective colchicine effect are discussed.
Loginov
A S
AS
Dzhalalov
K D
KD
Bendikov
E A
EA
Blok
Iu E
IuE
Chebanov
S M
SM
D000818:Animals; D003078:Colchicine / Q000627:therapeutic use*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D015786:Cytochromes b5; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000648:ultrastructure; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051381:Rats; D013050:Spectrometry, Fluorescence
D003573:Cytochrome b Group; D008054:Lipid Peroxides; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D003078:Colchicine
Eksperimental'noe obosnovanie primeneniia kolkhitsina pri alkogol'nykh porazheniiakh pecheni.