Pharmacological characterization of the effects of verapamil and nifedipine on isolated guinea-pig lung parenchymal strip.
Verapamil and nifedipine elicited dose-related relaxations and produced a right downward shift of the concentration-response curves to CaCl2, KCl, acetylcholine and histamine in the isolated guinea-pig lung parenchymal strip. These Ca-entry blockers had greater inhibitory effects on contractions evoked by CaCl2 and KCl than against those elicited by acetylcholine and histamine.
Cortijo
J
J
Perpiñá
M
M
Esplugues
J
J
Morcillo
E J
EJ
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002122:Calcium Chloride / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008168:Lung / Q000187:drug effects; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009543:Nifedipine / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology*
D006632:Histamine; D014700:Verapamil; D009543:Nifedipine; D007545:Isoproterenol; D002122:Calcium Chloride; D000109:Acetylcholine; D011188:Potassium; D002118:Calcium