Alterations in the effects of atropine on the behavior of pigeons following chronic administration.
The acute effects of atropine (0.01-1.0 mg/kg) on pigeons' key-pecking maintained under a variable-interval (VI) 60-sec schedule of food reinforcement were determined. Atropine decreased key-peck rates in a dose-dependent manner. A rate-decreasing dose of physostigmine, an acetylcholinesterase inhibitor, was studied in combination with the range of atropine doses. The rate reduction produced by physostigmine was attenuated by some doses of atropine. An atropine dose which decreased key-peck rates was then administered to the pigeons every day after their experimental sessions (chronic post-session phase). During this regimen, the dose-effect curves for atropine and the combination of atropine and physostigmine were redetermined. Atropine was then given chronically prior to experimental sessions (chronic pre-session phase), and the dose-effect curves for atropine and the combinations of atropine and physostigmine were determined again. The pigeons became tolerant to the rate-reducing effects of atropine following chronic post-session administration. Physostigmine's effect alone was unchanged following chronic atropine administration for two pigeons, and was slightly greater for a third. The rate reduction caused by physostigmine was attenuated across a wider range of atropine doses in the two pigeons for which the effect of physostigmine alone was unchanged. The atropine/physostigmine interaction curve for the third pigeon was shifted to the right following chronic post-session atropine administration. No further changes in effects of either atropine alone or in combination with physostigmine were seen following chronic pre-session atropine administration.(ABSTRACT TRUNCATED AT 250 WORDS)
Schaal
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University of Florida, Gainesville 32611.
Branch
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D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D010856:Columbidae; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004361:Drug Tolerance; D008297:Male; D010830:Physostigmine / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000187:drug effects; D012054:Reinforcement, Psychology
D011976:Receptors, Muscarinic; D001285:Atropine; D010830:Physostigmine