[Mechanisms of the damage to the liver monooxygenase systems in thermal ischemia].
It was shown in experiments in vitro that thermal ischemia of liver tissue leads to disorders in the function of membrane-bound microsomal monooxygenases. Disorders in the structural organization of membranes were also expressed in the inhibition of reactions of ascorbate-depending and fermentative peroxide oxidation of lipids and labilization of lysosomal membranes. Faults in the rate of amidopyrine n-demethylation and aniline n-hydroxylation correlate with the intensification of spontaneous peroxidation of lipids and activation of proteolytic processes in ischemia. The obtained data permitted to ground the approach to pharmacological prophylaxis of ischemic damages of liver microsomal monooxygenases.
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Sharapov
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Grek
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Dolgov
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D006358:Hot Temperature / Q000009:adverse effects*; D006900:Hydroxylation; D007511:Ischemia / Q000201:enzymology* / Q000209:etiology; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000098:blood supply*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009249:NADP / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D010105:Oxygenases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000814:Aniline Compounds; D008054:Lipid Peroxides; D000632:Aminopyrine; D008315:Malondialdehyde; D009249:NADP; D010105:Oxygenases; D001205:Ascorbic Acid; C023650:aniline
Mekhanizmy povrezhdeniia monooksigenaznykh sistem pecheni pri teplovoĭ ishemii.