Comparative results of 327 chemical carcinogenicity studies.
The National Cancer Institute (NCI) and the National Toxicology Program (NTP) have carried out a number of laboratory animal carcinogenicity studies and presented the results of these experiments in a series of Technical Reports. This paper tabulates the results of the 327 NCI/NTP studies carried out to date on 308 distinct chemicals, and discusses certain issues relevant to the evaluation of carcinogenicity in these experiments. This compilation of results from NCI/NTP carcinogenicity experiments provides a large database that can be used to study structure-activity correlations, interspecies concordance, and associations between laboratory animal carcinogenicity and other toxicological effects.
Haseman
J K
JK
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Huff
J E
JE
Zeiger
E
E
McConnell
E E
EE
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009316:National Institutes of Health (U.S.); D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D014481:United States
D002273:Carcinogens