Trisomy 4 identifies a subset of acute nonlymphocytic leukemias.
We present four patients with acute nonlymphocytic leukemia, one M2 and three M4 French-American-British (FAB) types and one patient with refractory anemia with excess of blasts in transformation who at diagnosis had trisomy of chromosome 4 as the primary karyotypic anomaly. This chromosome anomaly probably defines a previously undescribed subset of acute nonlymphoid leukemias. Hematologic characteristics commonly found in these patients were dysplastic features of all bone marrow lineages, suggesting that trisomy 4-associated disorders involve the early myeloid hematopoietic stem cell.
Mecucci
C
C
Van Orshoven
A
A
Tricot
G
G
Michaux
J L
JL
Delannoy
A
A
Van den Berghe
H
H
D000293:Adolescent; D000753:Anemia, Refractory / Q000150:complications; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002905:Chromosomes, Human, 4-5; D005260:Female; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000145:classification / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy