Accelerated development of cardiac sympathetic responses in spontaneously hypertensive (SHR) rats.
The functional development of cardiac and adrenal medullary responses to reflex activation of the sympathetic nervous system was studied in preweanling spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) normotensive rats. Pups of the two strains received injections of insulin or saline at 2, 4, 8, 12, or 16 days of age and were sacrificed 3 h later. Insulin administration produces a significant decrease in circulating levels of glucose which in turn results in a centrally mediated increase in sympathetic outflow. The induction of ornithine decarboxylase (ODC) in heart and the depletion of epinephrine from the adrenal medulla served as tissue markers of functional sympathetic neurotransmission. WKY and SHR pups had comparable levels of ODC activity in heart under basal conditions. In contrast, levels of catecholamines in the adrenals were greater in SHR pups at 2 and 4 days of age. Following insulin administration, SHR pups exhibited a greater induction of cardiac ODC activity at 2, 4, and 8 days of age compared to age-matched WKY controls. However, there were no differences between SHR and WKY pups in the magnitude of the adrenal medullary response to insulin-induced hypoglycemia. These alterations in sympathetic-target tissue development during the first postnatal week of life may contribute in part to the higher arterial pressures maintained by SHRs throughout the lifespan.
McCarty
R
R
Department of Psychology, University of Virginia, Charlottesville 22903-2477.
Kirby
R F
RF
Cierpial
M A
MA
Jenal
T J
TJ
D000313:Adrenal Medulla / Q000294:innervation; D000818:Animals; D000831:Animals, Newborn; D001143:Arousal / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism; D004790:Enzyme Induction; D004837:Epinephrine / Q000097:blood; D005260:Female; D006321:Heart / Q000294:innervation*; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009206:Myocardium / Q000201:enzymology; D009638:Norepinephrine / Q000097:blood; D009955:Ornithine Decarboxylase / Q000096:biosynthesis; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D001786:Blood Glucose; D009955:Ornithine Decarboxylase; D009638:Norepinephrine; D004837:Epinephrine