Choanal atresia and athelia: methimazole teratogenicity or a new syndrome?
An infant girl with choanal atresia, athelia, minor anomalies, and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol. The patient's defects may be due to methimazole teratogenicity or could represent a previously undescribed syndrome affecting ectodermal structures.
Greenberg
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Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000328:Adult; D001940:Breast / Q000002:abnormalities*; D002675:Child, Preschool; D002754:Choanal Atresia / Q000139:chemically induced*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D007223:Infant; D007231:Infant, Newborn; D008713:Methimazole / Q000009:adverse effects* / Q000627:therapeutic use; D009558:Nipples / Q000002:abnormalities*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D013577:Syndrome
D008713:Methimazole