Use of a novel non-steroidal anti-inflammatory drug in the horse.
In a two-part cross-over experiment in six ponies, an acute inflammatory reaction was generated by injecting carrageenin solution into subcutaneously-implanted tissue-cages lined with fibrovascular granulation tissue. In each part of the cross-over, half of the ponies received a novel phenylpyrazoline anti-inflammatory agent (BW540C) orally and half received a placebo treatment. BW540C inhibited platelet cyclo-oxygenase for 24 h but the reductions in exudate eicosanoid concentrations were less pronounced. A significant suppression in the rise of surface skin temperature in BW540C-treated ponies paralleled drug-induced inhibition of thromboxane B2 bicyclic prostaglandin (PG) E2 concentrations at the inflamed site. The drug had no significant effect on 6-keto-PGF1 alpha, migrating leucocytes, lactate dehydrogenase or total protein in exudates. Maximum plasma concentrations of both compounds occurred 2 to 4 h after dosing and maximum exudate levels of drug and metabolite occurred at 12 h. Both compounds penetrated approximately three times less readily into exudate than into plasma.
Royal Veterinary College, North Mymms, Hatfield, Hertfordshire.
A J
AJ
Higgins
P
P
Lees
A D
AD
Sedgwick
A R
AR
Buick
R
R
Churchus
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D005122:Exudates and Transudates / Q000032:analysis / Q000187:drug effects; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses / Q000378:metabolism*; D007249:Inflammation / Q000188:drug therapy / Q000662:veterinary*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D011720:Pyrazoles / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D013929:Thromboxane B2 / Q000032:analysis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D013929:Thromboxane B2; C046216:BW 540C; D007770:L-Lactate Dehydrogenase