Identification of the classical androgen receptor in male rat liver.
Male rat liver contains components in both cytosol and nucleosol which bind the synthetic testosterone derivative, mibolerone, with a high affinity, low capacity and a high specificity for androgens. Gel filtration chromatography shows two binding components. A high molecular weight component (M.Wt 230,000) present in cytosol alone and a low molecular weight component (M.Wt 60,000) present in cytosol and nucleosol. Male rat liver contains the classical androgen receptor.
P
P
Bannister
V A
VA
Randall
P
P
Sheridan
M S
MS
Losowsky
D000726:Androgen Antagonists / Q000378:metabolism; D000728:Androgens / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive; D002467:Cell Nucleus / Q000032:analysis; D002850:Chromatography, Gel; D003600:Cytosol / Q000032:analysis; D004967:Estrogens / Q000378:metabolism; D006854:Hydrocortisone / Q000378:metabolism; D008099:Liver / Q000032:analysis*; D008297:Male; D008970:Molecular Weight; D009277:Nandrolone / Q000031:analogs & derivatives / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011944:Receptors, Androgen / Q000302:isolation & purification*
D000726:Androgen Antagonists; D000728:Androgens; D004967:Estrogens; D011944:Receptors, Androgen; D009277:Nandrolone; C100075:mibolerone; D006854:Hydrocortisone