In vivo oxidants and pulmonary inflammation.
Endotoxemia is used as a model of the adult respiratory distress syndrome in chronically instrumented awake sheep. The toxic effects of endotoxin may be mediated through inflammatory cells and the release of toxic oxidants. N-acetylcysteine (NAC) inhibits the in vivo effects of endotoxemia in chronically instrumented unanesthetized sheep. NAC also functions as a free radical scavenger in vitro. It is possible that the protective effects of pretreatment with NAC result from NAC's ability in vivo to protect against local oxidant injury.
J R
JR
Snapper
G R
GR
Bernard
K L
KL
Brigham
D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D004195:Disease Models, Animal; D004731:Endotoxins / Q000097:blood*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*; D012756:Sheep
D004731:Endotoxins; D000111:Acetylcysteine