Ceftriaxone effect on bilirubin-albumin binding.
The effect of ceftriaxone on bilirubin-albumin binding was measured in vitro using the peroxidase method with human serum albumin and a dialysis rate method with adult and newborn serum. Ceftriaxone competes with bilirubin for binding to human serum albumin; the displacement constant is 1.5 X 10(4) L/mol. Therapeutic levels of ceftriaxone decrease the reserve albumin concentration in newborn serum by 39%. These results indicate that ceftriaxone may increase the risk of bilirubin encephalopathy in jaundiced premature infants.
Department of Pediatrics, Medical College of Georgia, Augusta 30912.
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S
Fink
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Karp
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Robertson
D000328:Adult; D001663:Bilirubin / Q000097:blood*; D001667:Binding, Competitive; D002443:Ceftriaxone / Q000097:blood / Q000494:pharmacology*; D003622:Dapsone / Q000031:analogs & derivatives / Q000097:blood; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D010084:Oxidation-Reduction; D012709:Serum Albumin / Q000378:metabolism*
D012709:Serum Albumin; D002443:Ceftriaxone; D003622:Dapsone; C018965:monoacetyldapsone; D001663:Bilirubin