Vitamin E stimulates proliferation of experimental oral carcinoma cells in vitro.
Vitamin E was found to have a stimulatory effect on the growth in culture of an epidermoid carcinoma cell line derived from chemically induced tumors of hamster buccal pouch. This effect was found to be dose related, with a maximum stimulatory effect at 10 microM. At a concentration of 100 microM, there was an inhibitory effect on both cell turnover and colony formation.
Odukoya
O
O
Schwartz
J
J
Shklar
G
G
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D009062:Mouth Neoplasms / Q000378:metabolism*; D013997:Time Factors; D014410:Tumor Stem Cell Assay; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E