Amyloidosis presented with whitening and loss of hair which improved after dimethylsulfoxide (DMSO) treatment.
A 67-year-old male patient presented with rapid progression of whitening and loss of hair in past 2 months was consulted due to the suspicion of hypothyroidism. He had been told to have cardiomegaly for 3 years. Thyroid function was within normal limit. Prostate biopsy was performed because of prostatic hypertrophy and mild elevation of serum acid phosphatase. Amyloid accumulation was observed in the biopsy specimen. Subsequent skin biopsies revealed the same result. The scalp hair and beard grew and turned to black gradually several months after dimethyl sulfoxide (DMSO) treatment. These findings suggest that some of the manifestation of amyloidosis may respond to DMSO treatment.
Division of Endocrinology and Metabolism, Jichi Medical School, Tochigi-ken, Japan.
S D
SD
Hsieh
R
R
Yamamoto
K
K
Saito
Y
Y
Iwamoto
T
T
Kuzuya
S
S
Ohba
S
S
Kobori
K
K
Saito
D000686:Amyloidosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D001706:Biopsy; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000627:therapeutic use*; D006201:Hair Diseases / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology
D004121:Dimethyl Sulfoxide