Surgery in combined pulmonary and neural cryptococcosis.
A 39-year-old previously healthy patient with combined pulmonary and neural cryptococcosis was successfully managed by pulmonary resection and antifungal chemotherapy. The pulmonary mass was removed under cover of miconazole and 5-fluorocytosine even though the patient had concomitant active meningitis. He recovered dramatically after the surgical procedure and remained well 2 years later. We suggest that, as in our patient, early removal of a pulmonary cryptococcal mass under antifungal cover may in other similar patients obviate the need for protracted antifungal therapy and lead to an excellent response of the neural cryptococcosis.
University Department of Neurology, IbnSina Hospital, Kuwait.
M A
MA
Sa'adah
R A
RA
Shakir
S I
SI
Jadaa
V
V
Bezjak
G F
GF
Araj
D000328:Adult; D003131:Combined Modality Therapy; D003453:Cryptococcosis / Q000188:drug therapy / Q000601:surgery*; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications / Q000601:surgery*; D008297:Male; D008581:Meningitis / Q000150:complications / Q000188:drug therapy*; D008825:Miconazole / Q000627:therapeutic use
D008825:Miconazole; D005437:Flucytosine