[Toxicological studies on (2''R)-4'-O-tetrahydropyranyladriamycin, a new antitumor antibiotic. Acute toxicity study in mice].
A new antitumor anthracycline antibiotic; (2''R)-4'-O-tetrahydropyranyladriamycin hydrochloride (THP) was administered to ddY mice via different routes for acute toxicity studies. The LD50 values were calculated from mortality rates during a 14-day observation period, and were 14-21 mg/kg when i.v., i.p. or s.c. route was used and 420-570 mg/kg when the drug was given p.o. Upon administration of the drug, mice showed depression of spontaneous activity, anorexia, diarrhea and slight alopecia. Autopsy of the mice killed by the drug revealed atrophy of thymus, spleen, testes, uterus and ovaries, and congestion and hemorrhage in the intestines. The mice which survived through the observation period, however, showed only atrophy of thymus and sexual organs.
Tone
H
H
Shirai
M
M
Onoue
F
F
Kumagai
H
H
D000284:Administration, Oral; D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D012737:Sex Factors
D004317:Doxorubicin; C027260:pirarubicin