The potassium content of heart muscle following cyclosporine.
The potassium content of cardiac muscle was examined after 9 or 22 days of cyclosporine A administration in normal rats and rats exposed to either renovascular, Goldblatt hypertension or renal ischemia. Cyclosporine A did not result in any alteration in cardiac muscle potassium compared to untreated rats in either group, even though the animals which had been subjected to renal ischemia and cyclosporine A plasma potassium was raised compared to animals subjected just to renal ischemia. The potassium content of cardiac muscle, however, was found to be raised in the hypertrophic hearts of the Goldblatt, renovascular hypertensive animals, both with and without cyclosporine.
Thiel
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G
Seiler
H
H
Hermle
M
M
Brunner
F P
FP
D000818:Animals; D003524:Cyclosporins / Q000633:toxicity*; D006977:Hypertension, Renal / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism; D007668:Kidney / Q000098:blood supply; D009206:Myocardium / Q000378:metabolism*; D009392:Nephrectomy; D011188:Potassium / Q000097:blood / Q000378:metabolism*; D051381:Rats
D003524:Cyclosporins; D011188:Potassium