[Activity of enzymes of xenobiotic metabolism in the liver of rats with vitamin A deficiency and mycotoxicosis T-2].
Keeping male rats within a month on a ration deficient in vitamin A led to a distinct decrease in content of cytochrome P-450, in activities of carboxylase, epoxide hydrolase, aniline hydrolase and to a slight inhibition of UDP-glucuronosyl transferase in live tissue. At the same time, activity of glutathione transferase and content of reduced glutathione in liver tissue were increased. After administration of the epoxide-containing T-2 mycotoxin into rats within 10 days at a dose of 0.54 mg/kg activity of the enzymes catalyzing metabolism of xenobiotics was inhibited in the animals maintained on the complete half-synthetic ration, except of epoxide hydrolase and glutathione transferase, activity of which was elevated. The administration of T-2 toxin under conditions of deficiency in vitamin A caused especially distinct inhibition of the enzymes involved in the 1 phase of xenobiotic metabolism but it was accompanied by only slight increase in T-2 toxicosis. The enzymes participating in conjugation of xenobiotics as well as epoxide hydrolase appear to play major roles in detoxication of T-2 mycotoxin.
A E
AE
Kranauskas
L V
LV
Kravchenko
I Ia
IIa
Kon'
V A
VA
Tutel'ian
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008658:Inactivation, Metabolic; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D008361:Mannosidases / Q000097:blood / Q000378:metabolism; D009145:Mushroom Poisoning / Q000201:enzymology* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000506:poisoning*; D013605:T-2 Toxin / Q000378:metabolism / Q000506:poisoning*; D014802:Vitamin A Deficiency / Q000201:enzymology* / Q000378:metabolism; D043323:alpha-Mannosidase
D012717:Sesquiterpenes; D003577:Cytochrome P-450 Enzyme System; D008361:Mannosidases; D043323:alpha-Mannosidase; D013605:T-2 Toxin
Aktivnost' fermentov metabolizma ksenobiotikov v pecheni krys pri nedostatochnosti vitamina A i mikotoksikoze T-2.