[Effect of the tumor-growth promoter 12-O-tetradecanoylphorbol-13-acetate on the proliferation of different clones of mouse tumor cells in a semiliquid medium].
The effect of tumour promoter, 12-0-tetradecanoylphorbol-13-acetate (TPA), on the cloning efficiency of different clones of mouse tumour cells was studied in semi-solid medium. The clones varied in their response to TPA. Inhibition and inherited stimulation of colony-formation efficiency in semi-solid medium was revealed. One clone did not respond to TPA. The influence of environmental factors on the clone structure and tumour progression is discussed.
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Brodskaia
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002999:Clone Cells / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D003470:Culture Media / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects; D005784:Gene Amplification / Q000187:drug effects; D008747:Methylcellulose / Q000494:pharmacology; D051379:Mice; D008806:Mice, Inbred AKR; D008808:Mice, Inbred CBA; D010704:Phorbols / Q000494:pharmacology*; D012513:Sarcoma, Experimental / Q000235:genetics / Q000503:physiopathology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D003470:Culture Media; D010704:Phorbols; D008747:Methylcellulose; D013755:Tetradecanoylphorbol Acetate; D003078:Colchicine
Vliianie promotora opukholevogo rosta 12-O-tetradekanoilforbol-13-atsetata na proliferatsiiu razlichnykh klonov opukholevykh kletok myshi v poluzhidkoĭ srede.