The effect of the phytoalexins, lubimin, (-)-maackiain, pinosylvin, and the related compounds dehydroloroglossol and hordatine M on human lymphoblastoid cell lines.
We have tested the effect of the phytoalexins lubimin, (-)-maackiain and pinosylvin and the related compounds dehydroloroglossol and hordatine M on the growth of the human lymphoblastoid cell lines Molt and Raji. (-)-maackiain, pinosylvin and dehydroloroglossol showed significant growth inhibitory action on the cells. Suppression of [3H] thymidine and [3H] leucine uptake was tested and noted in pinosylvin and dehydroloroglossol. The phytoalexins and related compounds are widespread in plants and provide a potential source of antineoplastic substances.
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D000376:Agmatine; D001578:Benzopyrans / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002934:Cinnamates; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D010616:Phenanthrenes / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D014176:Protein Biosynthesis; D036343:Pterocarpans; D012717:Sesquiterpenes / Q000494:pharmacology; D013267:Stilbenes / Q000494:pharmacology; D013729:Terpenes; D000094162:Phytoalexins
D001578:Benzopyrans; D002934:Cinnamates; D010616:Phenanthrenes; D010936:Plant Extracts; D036343:Pterocarpans; D012717:Sesquiterpenes; D013267:Stilbenes; D013729:Terpenes; C044124:lubimin; C049034:dehydroloroglossol; C049033:hordatine M; D000376:Agmatine; C049032:pinosylvin; C001449:inermin; D000094162:Phytoalexins