3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 5. 6-(Fluoren-9-yl)- and 6-(fluoren-9-ylidenyl)-3,5-dihydroxyhexanoic acids and their lactone derivatives.
A limited study was conducted to determine the biological consequences of rendering the phenyl rings of the previously reported 7-(3,5-disubstituted [1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acids coplanar. Such constraint substantially diminished intrinsic HMG-CoA reductase inhibitory activity.
Stokker
G E
GE
Alberts
A W
AW
Gilfillan
J L
JL
Huff
J W
JW
Smith
R L
RL
D000818:Animals; D002208:Caproates / Q000494:pharmacology*; D005449:Fluorenes / Q000494:pharmacology*; D006880:Hydroxy Acids / Q000494:pharmacology; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007783:Lactones; D008099:Liver / Q000201:enzymology; D051381:Rats; D013329:Structure-Activity Relationship
D002208:Caproates; D005449:Fluorenes; D006880:Hydroxy Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007783:Lactones