Fertility and pregnancy after operation for a prolactinoma.
Pituitary exploration was performed in 40 women with hyperprolactinaemic infertility and a prolactinoma was found in 37. After operation 26 (65%) of the 40 patients had a normal serum prolactin concentration; 31 women have so far had 49 pregnancies; in seven of these patients bromocriptine therapy was used after surgery. Eight of the remaining nine women were shown to be ovulating, but four of these subsequently decided not to attempt a pregnancy. The course and outcome of the 49 pregnancies were similar to those in normal women and no visual or endocrine complications occurred. Surgical removal of a prolactinoma often restores fertility, and may secure a safer pregnancy.
A M
AM
Richards
M R
MR
Bullock
G M
GM
Teasdale
J A
JA
Thomson
M I
MI
Khan
D000236:Adenoma / Q000378:metabolism* / Q000601:surgery; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D010902:Pituitary Gland / Q000502:physiology; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000601:surgery; D011247:Pregnancy; D011388:Prolactin / Q000097:blood / Q000378:metabolism*
D011388:Prolactin