Hyperglycemic activity in dogs of recombinant DNA-derived 20,000 dalton variant of methionyl human growth hormone.
The recombinant DNA-derived 20,000-dalton variant of N-terminal methionyl human growth hormone (20K-Met-hGH) had a hyperglycemic effect in fasted dogs when injected 11 hours prior to an oral glucose tolerance test (OGTT). These results reported here suggest that 20K-Met-hGH can induce glucose intolerance in dogs similar to that produced by recombinant DNA-derived 22,000 dalton N-terminal methionyl human growth hormone (22K-Met-hGH) and the normal pituitary-source human growth hormone (22K-hGH).
Shaar
C J
CJ
Grinnan
E L
EL
Short
W G
WG
Powell
J G
JG
Bryan
N
N
Bemis
K G
KG
Tinsley
F C
FC
D000595:Amino Acid Sequence; D000818:Animals; D004285:Dogs; D005260:Female; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000494:pharmacology*; D006943:Hyperglycemia / Q000139:chemically induced*; D008970:Molecular Weight; D011994:Recombinant Proteins / Q000494:pharmacology*; D013997:Time Factors
D011994:Recombinant Proteins; D013006:Growth Hormone