Occurrence of short chain aliphatic diols in human blood: identification by gas chromatography-mass spectrometry.
Patients attending a general hospital for various reasons were screened for raised serum gamma glutamyltransferase (gamma-GT) and positive blood alcohol concentration (BAC). The results served as objective biochemical tests of heavy drinking. Among 419 individuals, 50 (11.9%) met these requirements and blood samples were used to determine the presence of low molecular mass aliphatic diols. 1,2-Propanediol, 2,3-butanediol and 2,2-dimethyl-1,3-propanediol were determined by gas liquid chromatography-mass spectrometry (GC-MS). In patients with blood ethanol concentration less than 2 mmol/l, 1,2-propanediol and 2,2-dimethyl-1, 3-propanediol mainly occurred together at median concentrations of about 200 mumol/l. When blood ethanol was 2-42 mmol/1,2,3-butanediol was also present covering a wide concentration range: three patients had concentrations between 6 and 10 mmol/l. There was no apparent correlation between the concentration of 2,3-butanediol and the concentration of blood ethanol. The diols were below the limits of detection in blood from nonintoxicated control individuals and hospital in-patients.
Sisfontes
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Nyborg
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Jones
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Blomstrand
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D000293:Adolescent; D000328:Adult; D000368:Aged; D002072:Butylene Glycols / Q000494:pharmacology*; D000431:Ethanol / Q000097:blood; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000097:blood*
D002072:Butylene Glycols; D011409:Propylene Glycols; D000431:Ethanol; C026978:2,3-butylene glycol; D019946:Propylene Glycol; C048799:2,2-dimethyl-1,3-propanediol