Influence of food on the pharmacokinetics of quinapril and its active diacid metabolite, CI-928.
A randomized two-way crossover study was conducted in 12 healthy volunteers to assess the effect of food on the pharmacokinetics of quinapril (CI-906) and its active metabolite, CI-928, after quinapril dosing. Forty-milligram oral quinapril doses were administered in a fasted or a fed state with a one-week washout period between treatments. No significant treatment differences were observed in quinapril and CI-928 values for maximum plasma concentration, area under the plasma concentration-time curve, or percentage of dose excreted in the urine. Small but significant increases of less than 0.5 hour in quinapril and CI-928 tmax values were observed after consumption of food. The pharmacokinetic profiles of quinapril and CI-928 were not significantly altered by the administration of food.
Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan 48105.
J J
JJ
Ferry
A M
AM
Horvath
A J
AJ
Sedman
J R
JR
Latts
W A
WA
Colburn
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000493:pharmacokinetics*; D002849:Chromatography, Gas; D005502:Food; D006801:Humans; D007546:Isoquinolines / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D000077583:Quinapril; D044005:Tetrahydroisoquinolines
D000806:Angiotensin-Converting Enzyme Inhibitors; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C054501:quinaprilat; D000077583:Quinapril