The effect on brain 5-HT of central lysine-vasopressin administration into different cerebral ventricular compartments depends on the site of injection.
The influence of lysine-8-vasopressin (LVP) on the steady-state level of serotonin was studied in different brain regions four hours after microinjection into the lateral ventricle (icv) or cisterna magna (cm). LVP (200 pg) increased the serotonin (5-HT) level in the hypothalamus and mesencephalon after cm application, while icv administration caused an opposite tendency. The findings suggest that the site of peptide administration is of decisive importance in the mediation of various effects of LVP on the transmitter metabolism. A possible link exists between opposite effects of cm versus icv injection of LVP on central serotoninergic mechanisms, as well as on behavioral and autonomic correlates of these treatment.
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Günther
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Szabó
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Kovács
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Telegdy
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D007031:Hypothalamus / Q000378:metabolism; D007276:Injections, Intraventricular; D008236:Lypressin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008636:Mesencephalon / Q000378:metabolism; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D008236:Lypressin