DES induced sperm destruction in Lakeview hamsters.
DES toxicity on sperm production after five consecutive sublethal i.p. injections of 8, 40 and 200 mg/kg was investigated in Lakeview hamsters. Testis weight, caudal sperm number, sperm morphology and body weight were monitored at week 1, 4 and 10 after treatment. DES doses of 8 mg/kg or above caused complete destruction of caudal sperm and reduced testes size to almost 10% of control within 10 weeks. Some sperm production resumed after the 8 mg/kg dose at the 10th week but more than half of these cells were abnormal in shape. Body weights remained almost stable for the first 4 weeks and then increased gradually by 25% at the 10th week.
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Singh
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Patterson
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006224:Cricetinae; D004054:Diethylstilbestrol; D008297:Male; D009929:Organ Size / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000187:drug effects
D004054:Diethylstilbestrol