Effect of terguride on prolactin levels in normal, puerperal and hyperprolactinaemic women.
Terguride, is an 8 - alpha - ergoline derived from lisuride, acts as a partial dopamine (DA) agonist. The effect and tolerance of terguride has been investigated by an acute administration of 0.2 mg p.o. to 8 normal women, 8 patients with hyperprolactinaemia and 8 women with puerperal hyperprolactinaemia. Prolactin (PRL) levels were markedly suppressed in all subjects, with no significant differences between the groups. Treatment for 5 days with terguride 0.4 mg/day or 0.8 mg/day was studied as an inhibitor of lactation. PRL levels were suppressed in a dose-related manner. No untoward side-effects were noted.
P L
PL
Venturini
R
R
Horowski
M
M
Valenzano
S
S
Costantini
V
V
Fasce
F
F
Gorlero
E
E
Rainer
L
L
De Cecco
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004873:Ergolines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000188:drug therapy*; D007774:Lactation / Q000187:drug effects; D008090:Lisuride / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use*; D049590:Postpartum Period; D011247:Pregnancy; D011388:Prolactin / Q000097:blood*; D013997:Time Factors
D004873:Ergolines; C006208:dironyl; D011388:Prolactin; D008090:Lisuride