Ciglitazone is not itself thermogenic but increases the potential for thermogenesis in lean mice.
Chronic dietary administration of the oral hypoglycaemic ciglitazone (3 g/day for 14-28 days) to lean, non-diabetic CDl mice resulted in increased brown adipose tissue mitochondrial GDP binding and a marked increase in the thermic effect of the beta-adrenoceptor agonist BRL 26830A. However, ciglitazone was not itself thermogenic after an acute dose, nor did it raise resting metabolic rate during chronic dietary dosing.
Thurlby
P L
PL
Beecham Pharmaceuticals, Biosciences Research Centre, Epsom, Surrey, UK.
Wilson
S
S
Arch
J R
JR
D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002151:Calorimetry; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D006153:Guanosine Diphosphate / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D051379:Mice; D013844:Thiazoles / Q000494:pharmacology*; D045162:Thiazolidinediones
D007004:Hypoglycemic Agents; D013844:Thiazoles; D045162:Thiazolidinediones; D006153:Guanosine Diphosphate; C039671:ciglitazone