Participation of tumor killing factor in the antitumor effect of Sarcophaga lectin.
Antibody against tumor-killing factor inhibited cytotoxic activities produced in vitro by mouse peritoneal macrophages and in vivo in the serum of tumor-bearing mice in response to Sarcophaga lectin. These results suggest that tumor-killing factor participates in the antitumor effect of Sarcophaga lectin.
Itoh
A
A
Ohsawa
F
F
Ohkuma
Y
Y
Natori
S
S
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic; D004175:Diptera; D006023:Glycoproteins / Q000276:immunology*; D007106:Immune Sera / Q000494:pharmacology; D019476:Insect Proteins; D037102:Lectins / Q000494:pharmacology* / Q000627:therapeutic use; D037181:Lectins, C-Type; D008264:Macrophages / Q000276:immunology; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000276:immunology*; D012510:Sarcoma 180 / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha
C043030:20kDa lectin protein, Sarcophaga; D006023:Glycoproteins; D007106:Immune Sera; D019476:Insect Proteins; D037102:Lectins; D037181:Lectins, C-Type; D014409:Tumor Necrosis Factor-alpha