Contrast enhancing lesions in progressive multifocal leukoencephalopathy: a clinicopathological correlation.
A 60 year old man with chronic lymphocytic leukemia (CLL) developed a subacute neurological illness associated with multiple contrast enhancing lesions on CT scan. At autopsy large demyelinating lesions characteristic of progressive multifocal leukoencephalopathy (PML) were found in the right cerebral hemisphere surrounded by a dense leukemic infiltrate. The areas of contrast enhancement, highly unusual for PML, coincided with the CLL infiltrate.
Shafran
B
B
Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
Roke
M E
ME
Barr
R M
RM
Cairncross
J G
JG
D001932:Brain Neoplasms / Q000473:pathology*; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000473:pathology; D014057:Tomography, X-Ray Computed