Studies directed toward introduction of N6-isopentenyladenosine and its 2-methylthio analogue into oligoribonucleotides.
A new efficient route of i6A and ms2i6A synthesis, especially useful for the preparation of i6A-containing oligoribonucleotides eg. Api6A has been proposed. The method is based on aminolysis of a 6-methylsulfonylpurine system formed by oxidation of its 6-methylthio precursor.
Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland.
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Swiderski
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Dembek
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Biała
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Adamiak
D000241:Adenosine / Q000031:analogs & derivatives*; D007202:Indicators and Reagents; D007541:Isopentenyladenosine / Q000031:analogs & derivatives*; D009843:Oligoribonucleotides / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D009843:Oligoribonucleotides; C008503:2-methylthio-N-6-isopentenyladenosine; D007541:Isopentenyladenosine; D000241:Adenosine