Effect of electrical stimulation on the viability of the hippocampal slice preparation.
Continuous electrical stimulation of rat hippocampal slices at a frequency of 1 Hz brought about a 50% decline in the evoked population spike amplitude at a rate 5 times faster than that caused by very low frequency (1/600 Hz) stimulation. Within 2 hr after the high frequency stimulation began the evoked response totally disappeared. By contrast low frequency stimulated slices maintained an evoked response for at least 9 hr. Continuous electrical stimulation, especially at high frequency seems to facilitate the deterioration of the in vitro hippocampal slice preparation.
A
A
Schurr
K H
KH
Reid
M T
MT
Tseng
H L
HL
Edmonds
C A
CA
West
B M
BM
Rigor
D000818:Animals; D002470:Cell Survival; D004558:Electric Stimulation; D005071:Evoked Potentials; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains