A solution to the problem of 3'----2'-O-phosphoryl migration in oligoribonucleotide synthesis.
Oligoribonucleotides were obtained without contamination of 2'-5' linked regioisomers by means of polymer support when Thp group was employed as 2'-hydroxyl protecting group.
Tanimura
H
H
Department of Life Chemistry, Tokyo Institute of Technology, Yokohama, Japan.
Fukazawa
T
T
Sekine
M
M
Hata
T
T
D007202:Indicators and Reagents; D007536:Isomerism; D008722:Methods; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D014500:Uracil Nucleotides
D007202:Indicators and Reagents; D009843:Oligoribonucleotides; D014500:Uracil Nucleotides