Effect of dietary vitamin E on the production of platelet 12-hydroxyeicosatetraenoic acid (12-HETE).
Collagen and thrombin challenged platelets from vitamin E-deficient rabbits generated significantly more 12-HETE when compared to the platelets from vitamin E-supplemented rabbits. Similarly, conversion of arachidonic acid to 12-HETE was increased in platelets from vitamin E-deficient rabbits. These data show that vitamin E plays a role not only in deacylation of platelet phospholipids but also in the lipoxygenase mediated reactions.
K A
KA
Pritchard
N J
NJ
Greco
R V
RV
Panganamala
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D003094:Collagen / Q000494:pharmacology; D006893:Hydroxyeicosatetraenoic Acids / Q000097:blood*; D066298:In Vitro Techniques; D008297:Male; D011817:Rabbits; D013917:Thrombin / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000097:blood
D006893:Hydroxyeicosatetraenoic Acids; D014810:Vitamin E; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D003094:Collagen; D013917:Thrombin