Mebendazole 500 mg for single-dose treatment of nematode infestation.
Single 500 mg doses of mebendazole (Vermox; Janssen) were administered to 211 children aged 5 - 16 years in a rural area for treatment of single and mixed infestations with Ascaris lumbricoides, hookworm and Trichuris trichiura; the majority of subjects had low egg counts. Treatment was particularly effective against Ascaris, less effective against hookworm and promising against Trichuris. In most refractory cases egg output was considerably reduced. Treatment resulted in fewer Ascaris (95%) and hookworm (84%) ova reaching the environment. The results compare well with those obtained elsewhere in the world. One case of Strongyloides stercoralis infestation appeared after treatment. The drug was well tolerated and no side-effects were observed.
Research Institute for Diseases in a Tropical Environment, South African Medical Research Council, Nelspruit, Tvl.
A C
AC
Evans
A W
AW
Hollmann
L
L
du Preez
D000293:Adolescent; D001196:Ascariasis / Q000188:drug therapy; D002648:Child; D005260:Female; D006725:Hookworm Infections / Q000188:drug therapy; D006801:Humans; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage* / Q000627:therapeutic use; D009349:Nematode Infections / Q000188:drug therapy*; D012424:Rural Population; D014257:Trichuriasis / Q000188:drug therapy
D008463:Mebendazole