Effects of cephacetrile on reproduction cycle.
The research of possible effects of cephacetrile (Celospor) on the reproductive function was carried out on two animal species, rats and rabbits. The animals were divided into experimental groups, each treated subcutaneously with different amounts of cephacetrile (50, 100 and 500 mg/kg/die), control group receiving physiological solution. Effects of the preparation on fertility and post-natal growth in rats were analyzed, and trials were performed to test perinatal toxicity and teratogenesis in rabbits. From the observation of the experimental data collected it can be assumed that cephacetrile, administered subcutaneously in the given doses--1, 2 and 10 times, respectively, higher than the maximum therapeutic dose advisable--does not alter fertility, gestation and post-natal development of term foetuses of rats and fertility and gestation of rabbits.
Esposti
G
G
Esposti
D
D
Guerino
G
G
Bichisao
E
E
Fraschini
F
F
D000818:Animals; D002505:Cephacetrile / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D002511:Cephalosporins / Q000494:pharmacology*; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D007279:Injections, Subcutaneous; D008297:Male; D011247:Pregnancy / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects*
D002511:Cephalosporins; D002505:Cephacetrile