Pharmacokinetics of dezocine, a new analgesic: effect of dose and route of administration.
The pharmacokinetics of intravenous (IV) dezocine, and bioavailability of intramuscular (IM) and subcutaneous (SQ) dezocine, were evaluated in healthy male volunteers. Elimination half-life following 5, 10, and 20 mg IV doses averaged 2.6-2.8 h, and was independent of dose. Clearance decreased slightly, although significantly, with dose. After Deltoid IM injection, dezocine was rapidly absorbed (peak level: 0.6 h after dose), with bioavailability 97%. Thus dezocine has extensive distribution, high clearance and short half-life over a range of IV doses. It is rapidly and completely absorbed following IM or SQ administration.
Locniskar
A
A
Greenblatt
D J
DJ
Zinny
M A
MA
D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D001682:Biological Availability; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003516:Cycloparaffins / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D013764:Tetrahydronaphthalenes
D000700:Analgesics; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003516:Cycloparaffins; D013764:Tetrahydronaphthalenes; C010827:dezocine