[Effect of long-term ambulatory hypotensive treatment on the structural and functional status of the myocardium].
Changes in myocardial function and the possibility of a regression of left-ventricular hypertrophy were examined in patients with stable hypertension during a year of effective hypotensive treatment. Ninety-seven patients with essential hypertension, stage IIB (by Myasnikov's classification) and aged 35 to 56 years, were studied. Echography was conducted before the onset of treatment and after one year of regular hypotensive therapy. A marked hypotensive effect was noted in the course of treatment. Left-ventricular myocardial weight declined in 69% of patients, remained unchanged in 18.6% and increased in 12.4% despite the hypotensive effect of treatment. The reduction of left-ventricular hypertrophy was associated with no basic changes of myocardial pump function or contractility.
A P
AP
Iurenev
A L
AL
Nesterova
Z V
ZV
Beresneva
D000328:Adult; D000553:Ambulatory Care; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D013997:Time Factors
D000959:Antihypertensive Agents
Vliianie dlitel'nogo ambulatornogo gipotenzivnogo lecheniia na strukturno-funktsional'noe sostoianie miokarda.