[Changes in the leukocyte phagocytic activity of donor blood after its UV irradiation. I. Its relation to the irradiation dose and initial level of phagocytic activity].
Phagocytic activity of human mono- and granulocytes increased markedly after UV blood irradiation in the apparatus "Izolda" used in hospitals of the USSR for medical treatment. With the rise of irradiation dose the ratio of cells ingesting latex particles increased, although the average number of particles ingested per cell decreased. The integrative phagocytic index poorly depended on the irradiation dose. In patients with a low initial level of phagocytic index, after UV blood irradiation it became more pronounced than in those with the initial elevated level. The enhancement of phagocytic activity is the result of a direct UV-stimulation of cells. This stimulation not mediated by irradiated blood plasma is known to inhibit the phagocytic activity of leucocytes. A possible mechanism of phagocytic activity stimulation is discussed.
Obolenskaia
K D
KD
Freĭdlin
I S
IS
Samoĭlova
K A
KA
D001782:Blood Donors; D001804:Blood Transfusion, Autologous / Q000295:instrumentation; D004307:Dose-Response Relationship, Radiation; D006098:Granulocytes / Q000276:immunology / Q000528:radiation effects; D006801:Humans; D007962:Leukocytes / Q000276:immunology / Q000528:radiation effects*; D009000:Monocytes / Q000276:immunology / Q000528:radiation effects; D010587:Phagocytosis / Q000528:radiation effects*; D014466:Ultraviolet Rays; D014467:Ultraviolet Therapy / Q000295:instrumentation
Izmenenie fagotsitarnoĭ aktivnosti leĭkotsitov donorskoĭ krovi posle ee UF-oblucheniia. I. Zavisimost' ot dozy oblucheniia i iskhodnogo urovnia fagotsitarnoĭ aktivnosti.