Does dihydroergotamine reduce plasma volume?
Indications on a plasma volume reduction by dihydroergotamine (DHE) has been found in earlier studies. This study was made in order to further evaluate such a change. In animal experiments (sheep, n = 10) measurements were performed of red blood cell volume and plasma volume using radioactive labelling techniques. Red blood cell volume was unchanged but a plasma volume decrease of 10% was found after two hours and it persisted for 24 hours. In postoperative patients (n = 9), who had been given an infusion of ringer-glucose (5.5%) at a rate of 100 ml/hour, DHE caused an increase in diuresis but neither ADH (n = 9) nor aldosterone (n = 3) levels were changed. The data from the present study further support the earlier findings of a reduced plasma volume after DHE administration. The main effect of dihydroergotamine is on the vascular bed and especially on capacitance vessels (increased tonus). The reduced plasma volume by DHE seems to be one additional effect of DHE.
Bergqvist
D
D
Lindblad
B
B
D000450:Aldosterone / Q000097:blood; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects*; D004087:Dihydroergotamine / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D004911:Erythrocyte Volume / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D012756:Sheep; D014667:Vasopressins / Q000097:blood
D014667:Vasopressins; D004087:Dihydroergotamine; D000450:Aldosterone