On the repair of thymidine bromohydrins, damaged nucleosides: a possible new model for the damage and repair of nucleic acids.
Bromohydrins, which were damaged products of thymidines (2, 3, and 4), were repaired with sunlight or heat via a radical mechanism to regenerate the thymidines. A hypothesis for the biological significance of thymidine in DNA is presented.
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
T
T
Harayama
R
R
Yanada
T
T
Akiyama
M
M
Tanaka
F
F
Yoneda
D001966:Bromine; D055598:Chemical Phenomena; D002621:Chemistry; D004249:DNA Damage; D004260:DNA Repair; D006358:Hot Temperature; D010084:Oxidation-Reduction; D013472:Sunlight; D013936:Thymidine / Q000031:analogs & derivatives*
C054175:thymidine bromohydrin; D001966:Bromine; D013936:Thymidine