The amount of Tamm-Horsfall-protein in the human kidney, related to its daily excretion.
1. The amount of Tamm-Horsfall-protein in the human kidney was determined using zonal-immunoelectrophoresis. 2. A value of 115 micrograms Tamm-Horsfall-protein per gram kidney-tissue was found (1.3 micrograms Tamm-Horsfall-protein per mg protein), representing a total amount of about 40 mg Tamm-Horsfall-protein in both kidneys. 3. As the well documented daily excretion of Tamm-Horsfall-protein is 40 mg, i.e. in the range of its content in the kidneys, it is inferred that the total amount of Tamm-Horsfall-protein must be synthesized de novo each day.
Schoel
B
B
Institut für organische Chemie, Biochemie und Isotopenforschung der Universität Stuttgart.
Pfleiderer
G
G
D006801:Humans; D007122:Immunoelectrophoresis; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism*; D007672:Kidney Cortex / Q000378:metabolism; D009088:Mucoproteins / Q000378:metabolism* / Q000652:urine; D058949:Uromodulin
D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin