Discriminative stimulus properties of pentobarbital and progesterone in male and female rats.
Intact male and ovariectomized female rats were trained to discriminate 12 mg/kg pentobarbital from physiological saline. Generalization tests with different doses of pentobarbital did not reveal significant sex differences in the pentobarbital generalization gradient. Different doses of progesterone produced a generalization gradient to pentobarbital in ovariectomized females, but not in intact males. The results of the present experiment thus suggests that systemic administration of progesterone produces a "pentobarbital-like" stimulus in ovariectomized female rats, but not in intact males.
Netherlands Institute for Brain Research, Amsterdam.
R P
RP
Heinsbroek
F
F
van Haaren
F
F
Zantvoord
N E
NE
van de Poll
D000818:Animals; D004193:Discrimination Learning / Q000187:drug effects*; D005260:Female; D008297:Male; D010052:Ovariectomy; D010424:Pentobarbital / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology
D011374:Progesterone; D010424:Pentobarbital