Effects of pressure on uptake and release of calcium by brain synaptosomes.
Uptake of radioactive calcium from guinea pig brain fractions enriched in synaptosomes could be significantly and reproducibly decreased by exposure to high pressure. Calcium efflux from preloaded synaptosomes was unaffected by pressure exposure. It was hypothesized that the development of pressure-induced encephalopathy may be related to an effect of pressure on the central nervous system calcium transport system.
S C
SC
Gilman
K K
KK
Kumaroo
J M
JM
Hallenbeck
D000818:Animals; D001274:Atmospheric Pressure; D001693:Biological Transport, Active; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002493:Central Nervous System Diseases / Q000378:metabolism*; D006168:Guinea Pigs; D006610:High Pressure Neurological Syndrome / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D013574:Synaptosomes / Q000378:metabolism*
D002118:Calcium