Intestinal and femoral blood flow autoregulation in developing swine.
Pressure-flow relationships (P/F) in the small intestine or hindlimb circulation were used to examine autoregulation in 104 swine, aged 1 day to 2 months and anesthetized with pentobarbital. The P/F were obtained while perfusion pressure was decreased by compression of the abdominal aorta for 2 min at each pressure. Readjustments in vascular resistance stabilized within 2 min. Intestinal flow decreased with each decrease in pressure in swine 2 weeks old or younger, but was well maintained by 1 month of age. Femoral flow decreased with each decrease in pressure at all ages studied. Control experiments indicated that the observed vascular responses were independent of angiotension-II activity and were not reflex in origin.
Buckley
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NM
Brazeau
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P
Frasier
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ID
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001012:Aorta, Abdominal; D001794:Blood Pressure; D005269:Femur / Q000098:blood supply*; D006439:Hemodynamics; D007082:Ileum / Q000098:blood supply; D007421:Intestine, Small / Q000098:blood supply*; D007583:Jejunum / Q000098:blood supply; D008026:Ligation; D012039:Regional Blood Flow; D012079:Renal Circulation; D013552:Swine; D014655:Vascular Resistance