A circulating hypertensive factor in primary hypertension: effect of antihypertensive therapy.
In this study the role of a humoral hypertensive factor in spontaneously hypertensive rats (SHR) of the Münster strain was examined by cross-circulation. It was demonstrated that hypertension of the SHR could be transmitted to cross-circulation normotensive Wistar-Kyoto rats. The results led to the following conclusion: primary hypertension is caused by a circulating factor which is produced by kidneys and adrenals and suppressed by acute volume depletion and chronic dietary salt restriction. The antihypertensive effect of nifedipine probably leads to a compensatory stimulation of the hypertensive factor in SHR.
Medizinische Universitäts-Poliklinik, Münster, FRG.
U
U
Heckmann
E
E
Ottens
W
W
Zidek
H
H
Vetter
D000315:Adrenalectomy; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D003427:Cross Circulation; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D009392:Nephrectomy; D009543:Nifedipine / Q000627:therapeutic use*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D001798:Blood Proteins; D009543:Nifedipine