Implications of hypervitaminosis A on the calcium-phosphate metabolism and on blood lipids in hemodialysis.
Serum levels of vitamin A (VA) were measured in 71 hemodialysis (HD) patients and in 30 normal controls. 65 of the 71 patients were taking multivitamin preparations (MP) containing VA. The HD patients had significantly greater values: 7.81 +/- 2.86 mumol/l (224 +/- 82 micrograms/dl) versus 3.97 +/- 0.97 mumol/l (114 +/- 28 micrograms/dl; p less than 0.0005); those taking MP with large doses of VA showed the highest levels. Patients were divided as having normal (group I, n = 21) or elevated (group II, n = 50) serum levels of VA. Patients of group II had higher levels of serum calcium (Ca) and lower of serum phosphate (P) and PTH than those of group I. Four months after the withdrawal of oral VA, the serum levels of VA and Ca fell significantly in group II, while the serum P increased. On the contrary, in group I serum levels of VA, Ca and P remained unchanged. Serum triglycerides (TG) were significantly higher in group II but did not change after the withdrawal of VA. No differences between both groups of patients were observed for age, time on HD, residual diuresis, residual renal function, serum levels of cholesterol (CL) or anemia. A retrospective study of 18 hepatic biopsies of HD patients disclosed hyperplasia of Ito cells (VA-storaging cells) in 7 of them. These 7 biopsies belonged to patients who had taken large amounts of oral VA. Our data indicate that prolonged VA intake in HD patients is followed by an increase of serum CA, a decrease of serum P and PTH and a hepatic accumulation of VA.(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Nephrology, Hospital 1 Octubre, Madrid, Spain.
M
M
Praga
P
P
Diaz Rubio
J M
JM
Morales
F
F
Cañizares
L M
LM
Ruilope
V
V
Gutierrez-Millet
J
J
Nieto
J L
JL
Rodicio
D000293:Adolescent; D000328:Adult; D000368:Aged; D002118:Calcium / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002784:Cholesterol / Q000097:blood*; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000378:metabolism*; D006435:Renal Dialysis; D014280:Triglycerides / Q000097:blood*; D014801:Vitamin A / Q000009:adverse effects / Q000097:blood*
D010710:Phosphates; D014280:Triglycerides; D014801:Vitamin A; D002784:Cholesterol; D002118:Calcium