Radiation synovectomy with 165Dy-FHMA: lymph node uptake and radiation dosimetry calculations.
The lymph node uptake of 165Dy was measured in 25 patients treated by radiation synovectomy via intra-articular injection of 165Dy-ferric hydroxide macroaggregates (FHMA). An average of 0.12% of the injected dose was found in the inguinal lymph nodes 19h post injection. This results in a lymph node of 16.6 rad (166 mGy), a dose significantly less than that reported following radiation synovectomy with other radiocolloids. Dosimetry calculations for the intra-articular injection of 165Dy-FHMA are provided in the appendix.
Zalutsky
M R
MR
Venkatesan
P P
PP
English
R J
RJ
Shortkroff
S
S
Sledge
C B
CB
Adelstein
S J
SJ
D001172:Arthritis, Rheumatoid / Q000532:radiotherapy*; D004419:Dysprosium / Q000627:therapeutic use*; D005260:Female; D005290:Ferric Compounds / Q000627:therapeutic use*; D006207:Half-Life; D006801:Humans; D007501:Iron / Q000627:therapeutic use*; D007719:Knee Joint; D008099:Liver / Q000528:radiation effects; D008198:Lymph Nodes / Q000528:radiation effects*; D008953:Models, Anatomic; D010053:Ovary / Q000528:radiation effects; D011874:Radiometry; D011879:Radiotherapy Dosage; D013583:Synovial Membrane / Q000528:radiation effects*; D013997:Time Factors
D005290:Ferric Compounds; D004419:Dysprosium; C021024:ferric hydroxide; D007501:Iron