The prophylactic use of phenytoin during iopamidol contrast studies of the subarachnoid space.
Contrast examinations of the subarachnoid space are associated with side effects including convulsions. Attention has been given to the prophylactic use of anticonvulsants. We describe a simple oral regimen using the established anticonvulsant phenytoin that can be administered to short-stay patients and that achieves effective serum and CSF concentrations. A preliminary account of this work was presented to the British Pharmacological Society in January 1984 in London.
P J
PJ
de Vane
P
P
Macpherson
E
E
Teasdale
G
G
Volo
M
M
Casey
J C
JC
Kelly
B
B
Whiting
D003287:Contrast Media / Q000009:adverse effects*; D004569:Electroencephalography; D006801:Humans; D007479:Iopamidol; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D009192:Myelography; D010672:Phenytoin / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D013346:Subarachnoid Space
D003287:Contrast Media; D007483:Iothalamic Acid; D010672:Phenytoin; D007479:Iopamidol