Ro15-4513 differentially affects ethanol-induced hypnosis and hypothermia.
Recent reports of in vivo antagonism of the acute anti-conflict, ataxic, and lethal effects of ethanol with the partial inverse agonist imidazobenzodiazepine Ro15-4513 implicate the GABAa/benzodiazepine receptor in mediating several acute effects of ethanol. These data raise the question as to whether all of the acute effects of ethanol can be antagonized by Ro15-4513. The present study addressed this issue by investigating the effect of Ro15-4513 on ethanol-induced loss of righting reflex and hypothermia in mice. We found that Ro15-4513 antagonized the hypnotic, but not the hypothermic, effects of ethanol when tested under identical conditions. These results suggest that the GABAa/benzodiazepine receptor may not be involved in mediating all pharmacological effects of ethanol.
Syapin
P J
PJ
Department of Psychiatry, School of Medicine University of Southern California, Los Angeles 90033.
Gee
K W
KW
Alkana
R L
RL
D000818:Animals; D001386:Azides / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D007035:Hypothermia / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D001386:Azides; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D000431:Ethanol; C042957:Ro 15-4513