Fluorescent analogs of acyclic S-adenosyl-L-homocysteinase inhibitors.
Fluorescent analogs of S-adenosyl-L-homocysteinase inhibitors derived from acyclic nucleoside series have been synthetized by alkylation of heterocyclic bases with appropriate synthons, or by modification of preformed adenine derivatives. None of the newly prepared compounds derived from 2-aminopurine, lin-benzoadenine or 1,6-ethenoadenine significantly inhibited the above enzyme.
Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Praha.
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Dvoráková
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Holý
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D043383:Adenosylhomocysteinase; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D006867:Hydrolases / Q000037:antagonists & inhibitors*; D007202:Indicators and Reagents; D013329:Structure-Activity Relationship
D005456:Fluorescent Dyes; D007202:Indicators and Reagents; D006867:Hydrolases; D043383:Adenosylhomocysteinase; D000241:Adenosine