Ideal imaging in MR: contrast-enhancing pharmaceuticals. Evaluation of tempo carboxylic acid as nitroxide diagnostic agent.
The meglumine salt of TCA, a piperidinyl nitroxide stable free radical derivative, was tested as an NMR contrast enhancer. This report of its use in animals indicates its usefulness in the enhancement of signal intensity of the kidney and bladder.
Lamarque
J L
JL
Almès
C
C
Rouanet
J P
JP
Prat
X
X
Bruel
J M
JM
Pujol
J
J
Rodière
M J
MJ
Martin
J M
JM
Lopez
P
P
Rossi
M
M
D000818:Animals; D003497:Cyclic N-Oxides; D007668:Kidney / Q000033:anatomy & histology; D007674:Kidney Diseases / Q000175:diagnosis; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008536:Meglumine; D051381:Rats; D011919:Rats, Inbred Strains; D013113:Spin Labels; D001743:Urinary Bladder / Q000033:anatomy & histology
D003497:Cyclic N-Oxides; D013113:Spin Labels; C048737:tempo carboxylic acid; D008536:Meglumine