Effects of intravenous emulsified perfluorochemicals on hepatic cytochrome P-450.
Intravenous infusion of emulsified perfluorodecalin in rats caused a large increase in hepatic cytochrome P-450 concentration which persisted for many weeks. In contrast, hepatic cytochrome P-450 concentration was not changed significantly after infusion of perfluorotributylamine, but subsequent administration of phenobarbital caused the usual increase of cytochrome P-450. The cytochrome P-450 activity for demethylation of benzphetamine was decreased slightly after perfluorodecalin but was unchanged after perfluorotributylamine. The difference in the effects of these perfluorochemicals on hepatic cytochrome P-450 may be related to the difference in the time these compounds are retained in the liver.
Harrison Department of Surgical Research, School of Medicine, University of Pennsylvania, Philadelphia 19104.
R
R
Huang
D Y
DY
Cooper
H A
HA
Sloviter
D000818:Animals; D001589:Benzphetamine / Q000493:pharmacokinetics; D001802:Blood Substitutes; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004655:Emulsions; D005466:Fluorocarbons / Q000493:pharmacokinetics / Q000494:pharmacology*; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009929:Organ Size / Q000187:drug effects; D010634:Phenobarbital / Q000493:pharmacokinetics; D051381:Rats
D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; D001589:Benzphetamine; C008807:perfluorotributylamine; C008805:perfluorodecalin; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital