[Postoperative on-demand analgesia with fentanyl using the CODIC infusion system. Initial clinical experiences].
Postoperative patient-controlled analgesia (PCA) was studied in 24 ASA I-III patients recovering from major gynecological surgery, who were allowed to self-administer i.v. fentanyl doses by means of the CODIC programmable infusion system. The total dose was governed by a special algorithm which made demand doses decline with time in a pseudo-exponential manner; lockout time was 4 min. Duration of the PCA period was 16.6 +/- 5.3 h (mean, SD), during which time 409 +/- 170 micrograms fentanyl was infused. The analgesic efficacy was scored retrospectively as "moderate pain all the time". Half the fentanyl dose was administered during the first 6 h of treatment, when pain relief was significantly better than during the remainder of the study. Possible explanations for these observations are discussed.
Institut für Anaesthesiologie, Universität zu Köln.
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Lehmann
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Mehler
D003201:Computers; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage*; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D007260:Infusion Pumps; D008838:Microcomputers; D010149:Postoperative Pain / Q000188:drug therapy*; D012646:Self Administration / Q000295:instrumentation; D012984:Software
D005283:Fentanyl
Postoperative On-Demand Analgesie mit Fentanyl unter Verwendung des Infusionssystems CODIC.