Reduced bioavailability and effect of furosemide given with food.
10 healthy volunteers were given 40 mg furosemide p.o. with and without breakfast. The meal reduced the peak level of furosemide and decreased its bioavailability by approximately 30%. A heavy meal given to 5 of the subjects had no further effect. The reduced bioavailability caused a reduction in the diuretic effect.
B
B
Beermann
C
C
Midskov
D000328:Adult; D001682:Biological Availability; D004231:Diuresis / Q000187:drug effects; D005502:Food; D005665:Furosemide / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008297:Male
D005665:Furosemide