The trans-stilbene oxide-active glutathione transferase in human mononuclear leucocytes is identical with the hepatic glutathione transferase mu.
A glutathione transferase from human mononuclear leucocytes with high activity towards trans-stilbene oxide (GT-tSBO) was purified. GT-tSBO is expressed in only about 50% of the individuals studied. As judged from activity measurements, immunological studies and the fact that only those individuals who express glutathione transferase mu have high activity towards trans-stilbene oxide, it is concluded that the hepatic transferase mu is identical with the glutathione transferase (GT-tSBO) in mononuclear leucocytes.
Seidegård
J
J
Department of Molecular Ecogenetics, Wallenberg Laboratory, University of Lund, Sweden.
Guthenberg
C
C
Pero
R W
RW
Mannervik
B
B
D004137:Dinitrochlorobenzene / Q000378:metabolism; D005982:Glutathione Transferase / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D009504:Neutrophils / Q000201:enzymology*; D010641:Phenotype; D013267:Stilbenes / Q000378:metabolism
D004137:Dinitrochlorobenzene; D007527:Isoenzymes; D013267:Stilbenes; D005982:Glutathione Transferase; C025906:stilbene oxide