Disseminated intravascular coagulation and hypopotassemia associated with blast lung injury.
Forty six people were injured by a large explosive charge detonated in a Jerusalem bus. Four were killed instantaneously and 22 needed hospital care. We describe our experience in five patients with blast lung injury (BLI), all of whom survived in spite of severe respiratory failure requiring mechanical ventilation. Disseminated intravascular clotting (DIC) developed in three of the five patients and significant hypopotassemia ranging from 2.2 to 2.9 mEq/L in four. These two complications have not been previously described in association with BLI. Both DIC and hypopotassemia responded to replacement therapy. Vigorous treatment of respiratory failure, early recognition, and prompt correction of hemostatic and electrolyte abnormalities may have contributed to the avoidance of fatalities among the five patients with severe blast injury.
Melzer
E
E
Hersch
M
M
Fischer
D
D
Hershko
C
C
D000328:Adult; D001753:Blast Injuries / Q000150:complications* / Q000628:therapy; D001803:Blood Transfusion; D003131:Combined Modality Therapy; D004211:Disseminated Intravascular Coagulation / Q000209:etiology* / Q000628:therapy; D004630:Emergencies; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000209:etiology* / Q000628:therapy; D055370:Lung Injury; D008297:Male; D008875:Middle Aged; D011189:Potassium Chloride / Q000627:therapeutic use; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy
D011189:Potassium Chloride