Axonal regeneration through arterial grafts.
The left common peroneal nerves of adult inbred mice were severed and allowed to regenerate through the lumina of Y-shaped tubes comprising grafts of abdominal aorta and its bifurcation. Very little regeneration took place within the grafts unless the distal nerve stump was inserted into one limb of the Y-tube. Using syngeneic grafts virtually all the axons regenerating through the lumen grew down the limb of the Y-tube containing the distal nerve. Using non-syngeneic grafts, however, a substantial minority of the axons grew down the 'open' limb of the Y-tube. Axonal regeneration was more successful in non-syngeneic grafts.
Department of Anatomy and Biology as Applied to Medicine, Middlesex Hospital Medical School, London.
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Anderson
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Turmaine
D000818:Animals; D001012:Aorta, Abdominal / Q000637:transplantation* / Q000648:ultrastructure; D001369:Axons / Q000502:physiology*; D007083:Iliac Artery / Q000637:transplantation* / Q000648:ultrastructure; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009416:Nerve Regeneration; D010543:Peroneal Nerve / Q000502:physiology / Q000601:surgery / Q000648:ultrastructure; D013979:Tibial Nerve / Q000502:physiology / Q000601:surgery / Q000648:ultrastructure; D014185:Transplantation, Isogeneic