Low-threshold calcium electrogenesis in neocortical neurons.
In slices of parietal neocortex, evidence was obtained for the existence of a low-threshold Ca2+ conductance in most neurons. This conductance became apparent when resting membrane potential was held below -60 mV by continuously injected, depolarizing current. Under these conditions, brief hyperpolarizing pulses were followed by generation of tetrodotoxin (TTX)-resistant, Mn2+-sensitive, low-threshold spikes. The results suggest that in neocortex, as in many subcortical structures, low-threshold Ca current may be responsible for burst generation in some neurons.
Corob Center for Medical Research, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
A
A
Friedman
M J
MJ
Gutnick
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008345:Manganese / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009431:Neural Conduction / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010296:Parietal Lobe / Q000187:drug effects / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology
D008345:Manganese; D013779:Tetrodotoxin; D002118:Calcium