Transport of fluorescein monoglucuronide out of the vitreous.
The transport of fluorescein monoglucuronide, a fluorescent metabolite of fluorescein, from the vitreous was studied. Ten microliter of 1 mM fluorescein monoglucuronide or fluorescein solution was injected into the rabbit vitreous body, and the vitreous concentration was measured every 2 hr. The rate of loss from the vitreous was 0.066 +/- 0.012 (SD)/hour for fluorescein monoglucuronide and 0.22 +/- 0.029/hour for fluorescein. Systemically administered probenecid caused a statistically significant reduction in the loss from the vitreous of each of them.
Kitano
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Nagataki
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D000818:Animals; D000869:Anterior Eye Segment / Q000378:metabolism; D001692:Biological Transport; D019793:Fluorescein; D005452:Fluoresceins / Q000378:metabolism*; D005966:Glucuronidase / Q000378:metabolism; D007267:Injections; D007274:Injections, Intraperitoneal; D011339:Probenecid / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors; D014822:Vitreous Body / Q000378:metabolism*
D005452:Fluoresceins; C041357:fluorescein glucuronide; D005966:Glucuronidase; D011339:Probenecid; D019793:Fluorescein