Mitochondrial pyruvate carrier--a possible link between gluconeogenesis and ketogenesis in the liver.
Effects of various ketogenic substrates on gluconeogenesis from lactate or alanine were compared. The results suggest that, in intact liver cells, cytoplasmic pyruvate is transported into mitochondria in exchange for intramitochondrially generated acetoacetate. An interrelationship between gluconeogenesis and ketogenesis may thus exist in the liver at the level of mitochondrial pyruvate carrier.
Kümmel
L
L
Laboratory for Endocrinology & Metabolism, Charles University, Faculty of Medicine, Prague, Czechoslovakia.
D000090:Acetoacetates / Q000494:pharmacology; D000409:Alanine / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002478:Cells, Cultured; D005943:Gluconeogenesis / Q000187:drug effects; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D026901:Membrane Transport Proteins; D008930:Mitochondria, Liver / Q000378:metabolism*; D024101:Mitochondrial Proteins; D027501:Monocarboxylic Acid Transporters; D011773:Pyruvates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D000070590:Solute Carrier Proteins
D000090:Acetoacetates; D002352:Carrier Proteins; D007773:Lactates; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D027501:Monocarboxylic Acid Transporters; C000629174:Mpc1 protein, rat; D011773:Pyruvates; D000070590:Solute Carrier Proteins; D000409:Alanine