Determinants of vitamin D status in patients with hip fracture and in elderly control subjects.
The factors that influence vitamin D status were investigated in 125 patients with hip fracture and in 74 elderly control subjects. The serum concentrations of 25-hydroxyvitamin D [25(OH)D] varied with sunshine score and were paralleled by serum 1,25-dihydroxyvitamin D [1,25(OH)2D]. The control subjects showed a higher sunshine score and higher serum 24(OH)D levels than the patients with hip fracture. Dietary vitamin D intake was similar in both groups (mean 115 IU/d). A positive correlation between vitamin D intake and serum 25(OH)D was observed in the patients with low sunshine exposure. It appeared from this relation that dietary vitamin D intake should be approximately 300 IU/d to maintain an adequate serum (25(OH)D concentration. Vitamin D status was very poor in patients who were institutionalized before hip fracture. Multiple regression analysis on serum 25(OH)D confirmed the primary role of sunshine exposure as determinant of vitamin D status. The principal determinants of serum 1,25(OH)2D were serum 25(OH)D, serum creatinine, and serum phosphate.
Lips
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Department of Internal Medicine, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, the Netherlands.
van Ginkel
F C
FC
Jongen
M J
MJ
Rubertus
F
F
van der Vijgh
W J
WJ
Netelenbos
J C
JC
D000368:Aged; D002136:Calcium, Dietary / Q000008:administration & dosage; D004032:Diet; D005260:Female; D006620:Hip Fractures / Q000378:metabolism*; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood; D008297:Male; D013472:Sunlight; D014807:Vitamin D / Q000008:administration & dosage / Q000378:metabolism*
D002136:Calcium, Dietary; D006887:Hydroxycholecalciferols; D014807:Vitamin D