[The enzymes of the metabolism of exogenous compounds in the comparative assessment of the toxicity of trichothecene mycotoxins].
Moderate clinical, biochemical and hematologic signs of intoxication were observed in mice after single administration of HT-2 toxin (deacetylated derivative of T-2 toxin) in LD50 of 12.75 mg/kg or in 1/5 of LD50 for 7 days. The toxin produced no toxic effect when 1/10 and 1/50 of LD50 were administered for 14 days. With the dose exceeding 1/50 of LD50 a reduction in cytochrome P-450 content, carboxylesterase activity and increased activity of UDP-glucuronosyltransferase and glutathione transferase were recorded. T-2 toxin produced a more pronounced toxic effect, inhibited UDP-glucuronosyltransferase and insignificantly stimulated glutathione transferase activity. Lower HT-2 toxin toxicity is believed to depend on its ability to activate conjugation reactions to a greater extent than T-2 toxin.
Kravchenko
L V
LV
Levitskaia
A B
AB
Kranauskas
A E
AE
D000818:Animals; D001773:Blood Cells / Q000187:drug effects / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D004798:Enzymes / Q000097:blood*; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012717:Sesquiterpenes / Q000378:metabolism*; D013605:T-2 Toxin / Q000031:analogs & derivatives / Q000378:metabolism / Q000633:toxicity; D013997:Time Factors; D014255:Trichothecenes / Q000378:metabolism* / Q000633:toxicity
D004798:Enzymes; D012717:Sesquiterpenes; D014255:Trichothecenes; D013605:T-2 Toxin; C012351:HT-2 toxin
Fermenty metabolizma chuzherodnykh soedineniĭ pri sravnitel'noĭ otsenki toksichnosti trikhotetsenovykh mikotoksinov.