[Mutagenic effect of human adenovirus type I on the somatic and sex cells of male mice].
Human adenovirus 1 was studied for its effect on the chromosomal apparatus both in bone marrow cells and male sex cells of mice. Chromosome aberrations were most early detected in spermatocytes of the 1st order mice infected with human adenovirus 1. In bone marrow cells of mice the highest level of chromosome aberrations was observed 30, 60, 90 days after the inoculation, which corresponds to a more frequent detection of the adenoviral antigen. The UV-irradiated-virus caused chromosome aberrations in the later periods after the inoculation which might be induced by the virus reactivation in a cell.
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D000260:Adenoviruses, Human / Q000235:genetics* / Q000502:physiology; D000818:Animals; D001853:Bone Marrow / Q000382:microbiology* / Q000648:ultrastructure; D002869:Chromosome Aberrations; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D013090:Spermatocytes / Q000648:ultrastructure; D013093:Spermatogonia / Q000648:ultrastructure; D013737:Testis / Q000382:microbiology* / Q000648:ultrastructure; D013997:Time Factors; D014466:Ultraviolet Rays
Mutagennoe deĭstvie adenovirusa cheloveka tipa I na somaticheskie i polovye kletki samtsov mysheĭ.