[Histologic analysis of carcinoma of the cervix uteri in situ with graphic reconstruction].
With 38 selected conization specimens of histologically confirmed carcinoma in situ (C.I.S.), detailed graphic reconstructions were prepared in the form of schematic drawings to obtain exact information about the nature and extent of epithelial lesions in the cervix uteri. Because of a noticeable diversity from the accepted view, the results obtained by extensive histologic analysis were reported as follows. C.I.S. was divided into 2 groups, one originating from surface epithelia (14 cases) and the other arising from cervical glands (24 cases). C.I.S. developing from surface epithelia formed a single peak-shaped extent of epithelial lesion with one-side maturation toward the portio. The characteristic of intraepithelial spreading resulted in a "moving backward" extension. The criterion of the rate of spread depended upon the finding of involvement of the entire circumference of the external cervical os with a rather smaller area of lesions and adjacent epithelial repair to the C.I.S. C.I.S. arising from cervical glands disclosed an irregularly shaped extent of epithelial lesions. Convincing evidence of cervical glandular origin indicated lateral invasion of glandular involvement and the existence of glandular involvement just beneath intact surface columnar epithelia. Intraepithelial spread of C.I.S. extending from glandular involvement also displayed "moving backward" extension. C.I.S. lesions extending over a wide field of the cervix were compatible with slow growing type and long term staying in Stage O.
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Shiomi
D000328:Adult; D000367:Age Factors; D000368:Aged; D002278:Carcinoma in Situ / Q000473:pathology*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D008954:Models, Biological; D002583:Uterine Cervical Neoplasms / Q000473:pathology*