Stereoselective disposition of flupentixol: influence on steady-state plasma concentrations in schizophrenic patients.
Steady-state plasma concentrations of cis(Z)-flupentixol (active principle) and trans(E)-flupentixol (inactive) were measured in 41 patients at least on one occasion. Results indicate that concentrations of the trans-isomer are significatively higher. This demonstrates that the two isomers are not handled in the same way by the organism. This may be relevant if plasma level monitoring is performed using non-specific analytical methods.
Department of Psychiatry, University of Geneva, Switzerland.
A E
AE
Balant-Gorgia
L P
LP
Balant
M
M
Gex-Fabry
C
C
Genet
D002851:Chromatography, High Pressure Liquid; D005475:Flupenthixol / Q000097:blood*; D006801:Humans; D007536:Isomerism; D008991:Monitoring, Physiologic; D011863:Radioimmunoassay; D012559:Schizophrenia / Q000097:blood*; D013329:Structure-Activity Relationship; D013892:Thioxanthenes / Q000097:blood*
D013892:Thioxanthenes; D005475:Flupenthixol