Effect of coenzyme Q10 on endotoxin shock in dogs.
We studied the effects of coenzyme Q10 pretreatment on both pulmonary function and chemical mediators during endotoxin shock in dogs. Coenzyme Q10 pretreatment inhibited disturbances in peak airway pressure, total compliance of lung plus chest wall, lung clearance index, plasma histamine, base excess, and lactate; however, it had little effect on the circulation. The mechanism of coenzyme Q10's significant effects on pulmonary function during endotoxin shock is presently unknown.
K
K
Yasumoto
Y
Y
Inada
D000818:Animals; D001784:Blood Gas Analysis; D002302:Cardiac Output / Q000187:drug effects; D003067:Coenzymes; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006632:Histamine / Q000097:blood; D006863:Hydrogen-Ion Concentration; D008170:Lung Compliance / Q000187:drug effects; D008297:Male; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D012129:Respiratory Function Tests; D012772:Shock, Septic / Q000097:blood / Q000503:physiopathology*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
D003067:Coenzymes; D014451:Ubiquinone; D006632:Histamine; C024989:coenzyme Q10