[Feasibility of DNA impulse cytophotometry (ICP) in the diagnosis of squamous cell cancers of the oral cavity and oropharynx].
DNA ploidy and the proportion of DNA-synthesized cells (number of S-phase fractions) were measured by DNA impulse cytophotometry in 39 patients with untreated carcinomas of the oral cavity and the oropharynx. 84.7% of the tumours of the oral cavity and 80.8% of the tumours of the oropharynx were DNA-aneuploid. The mean value of S-phase fractions of the carcinomas of the oral cavity was 9.18 +/- 4.82%, that of the oropharynx carcinomas was 9.16 +/- 5.85%. There was no correlation between the type of DNA ploidy or the number of S-phase fractions and the presence of regional metastases and the clinical outcome of the tumour diseases. A case report suggests that determination of the number of S-phase fractions may give important information on the prognosticable effect of cytostatic therapy. So pretherapeutic ICP determination might become helpful with regard to the indications for cytostatic therapy of oro-pharyngeal tumours.
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Adler
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Feichter
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Maier
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D002455:Cell Division; D003592:Cytophotometry / Q000379:methods; D004273:DNA, Neoplasm / Q000378:metabolism*; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D010610:Pharyngeal Neoplasms / Q000175:diagnosis*; D011003:Ploidies
D004273:DNA, Neoplasm
Zur Anwendbarkeit der DNS-Impulszytophotometrie (ICP) bei der Diagnostik von Plattenepithelkarzinomen der Mundhöhle und des Oropharynx.