Effect of a beta-adrenoceptor antagonist, pindolol, on human uterine smooth muscle.
The effect of a beta-adrenoceptor antagonist, pindolol, on uterine smooth muscle in term pregnant women was studied in vitro and in vivo (in hypertensive women). In most preparations in vitro and in most patients in vivo, the drug induced an inhibitory effect on spontaneous uterine activity. The fetal heart rate was not affected by the drug. These actions of pindolol would make it an appropriate drug in the therapy of hypertension in pregnancy.
Department of Obstetrics and Gynaecology, University Hospital, Lund, Sweden.
I
I
Ingemarsson
P G
PG
Adaikan
S
S
Arulkumaran
S R
SR
Kottegoda
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D066298:In Vitro Techniques; D009215:Myometrium / Q000187:drug effects*; D010869:Pindolol / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D014590:Uterine Contraction / Q000187:drug effects
D010869:Pindolol