Inhibitors of histidine decarboxylase decrease basal gastric acid secretion in the rat.
We examined the ability of two specific inhibitors of histidine decarboxylase, (s)-alpha-fluoromethylhistidine (FMHd) and (s)-alpha-fluoromethylhistamine (FMHm), to inhibit basal gastric acid secretion. The two highest doses of FMHd administered, 50 and 100 mg/kg, decreased basal gastric acid secretion and total secretion volume but did not affect intraluminal pH. FMHm decreased gastric acid secretion, raised intraluminal pH, and to a lesser degree decreased total secretion volume. Neither compound changed the severity of gastric ulcers produced by cold restraint stress.
Department of Pharmacology and Therapeutics, University of Manitoba, Faculty of Medicine, Winnipeg.
V S
VS
Westerberg
J D
JD
Geiger
D000818:Animals; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000031:analogs & derivatives / Q000494:pharmacology; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors*; D008297:Male; D008762:Methylhistidines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000517:prevention & control
D008762:Methylhistidines; C054284:alpha-fluoromethylhistamine; C028309:alpha-fluoromethylhistidine; D006632:Histamine; D002262:Carboxy-Lyases; D006640:Histidine Decarboxylase