Indirect influence of s-triazines on rat gonadotropic mechanism at early postnatal period.
Daily s.c. injections of atrazine and deethylatrazine to rat mothers during pregnancy only or during pregnancy and lactation influenced the pituitary-gonadal axis of male and female offsprings. In female and male offspring, slow maturation of gonadotropic system is evident and as a consequence modified male and female pituitary 5 alpha-R activity is present. The number of specific steroid-hormone receptor sites at the offsprings' gonads is unchanged if the mothers were treated only during pregnancy, but 5 alpha-DHT prostate receptors are strongly inhibited in offspring of mothers treated with atrazine and deethylatrazine during pregnancy and lactation.
Faculty of Food Science and Biotechnology, University of Zagreb, Yugoslavia.
J
J
Kniewald
M
M
Peruzović
T
T
Gojmerac
K
K
Milković
Z
Z
Kniewald
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism; D000728:Androgens / Q000378:metabolism; D000818:Animals; D001280:Atrazine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity*; D005260:Female; D006066:Gonads / Q000187:drug effects / Q000502:physiology*; D007774:Lactation; D008297:Male; D008431:Maternal-Fetal Exchange; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology*; D011247:Pregnancy; D011467:Prostate / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011944:Receptors, Androgen / Q000378:metabolism; D011959:Receptors, Estradiol / Q000378:metabolism; D014599:Uterus / Q000187:drug effects / Q000378:metabolism
D000728:Androgens; D011944:Receptors, Androgen; D011959:Receptors, Estradiol; C027879:4-deethylatrazine; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase; D001280:Atrazine