Expression and transmission of a rodent retrovirus-like (VL30) gene family.
A transcriptionally active sub-set of the dispersed mouse VL30 family of proviral genetic elements was shown to be highly transmissible as a murine leukaemia virus pseudotype. Newly acquired VL30 proviruses (present at 1 to 2 copies per cell) were shown to be transcriptionally active. These data substantiate the hypothesis that this process of duplicative transposition may have played a major role in the evolution of the gene family and also demonstrate that VL30 elements would be capable of mediating oncogene activation by a promoter-insertion-type mechanism during leukaemia virus-induced tumourgenesis.
A T
AT
Carter
J D
JD
Norton
Y
Y
Gibson
R J
RJ
Avery
D000818:Animals; D002478:Cells, Cultured; D004279:DNA, Viral / Q000235:genetics; D005786:Gene Expression Regulation; D005814:Genes, Viral; D008745:Methylation; D051379:Mice; D012367:RNA, Viral / Q000235:genetics; D051381:Rats; D012190:Retroviridae / Q000235:genetics*; D014158:Transcription, Genetic
D004279:DNA, Viral; D012367:RNA, Viral