Alopecia induced in young mice by exposure to excess dietary zinc.
Second generation mice were exposed to normal (50 ppm, Group I) or excess (2000 ppm, Group II) zinc in the maternal diet during gestation and lactation, then weaned and continued on the mother's diet until sacrifice at 8 weeks. Tibia zinc reflected dietary intake. Group II had reduced plasma copper, body weight, and hematocrit; the second coat of hair appeared late and was lighter in color than Group I, possibly as an effect of copper and pigmentation development and hair growth.
S A
SA
Mulhern
W B
WB
Stroube
R M
RM
Jacobs
D000505:Alopecia / Q000139:chemically induced* / Q000503:physiopathology; D000818:Animals; D001835:Body Weight; D003300:Copper / Q000097:blood; D004032:Diet; D005260:Female; D006400:Hematocrit; D007774:Lactation; D008431:Maternal-Fetal Exchange; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D014886:Weaning; D015032:Zinc / Q000008:administration & dosage / Q000633:toxicity*
D003300:Copper; D015032:Zinc