Study of the teratogenic potential of gum arabic.
Gum arabic in the diet at 0, 1, 2, 4, 7.5 or 15% was available ad lib. to male and female Osborne-Mendel rats during premating and mating and throughout gestation. During gestation, the treated females consumed from 683 mg gum/kg body weight/day in the 1% group to 10,647 mg gum/kg/day in the 15% group. The animals were killed on gestation day 20. There were no dose-related changes in maternal findings, number of foetuses, foetal viability or external, visceral or skeletal variations. No terata were seen.
Collins
T F
TF
Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204.
Welsh
J J
JJ
Black
T N
TN
Graham
S L
SL
Brown
L H
LH
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000002:abnormalities; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D006170:Gum Arabic / Q000633:toxicity*; D008297:Male; D011134:Polysaccharides / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats
D011134:Polysaccharides; D006170:Gum Arabic