Equine leukocyte antigens: relationships with sarcoid tumors and laminitis in two pure breeds.
Frequencies of equine leukocyte antigen distribution were determined by complement-mediated cytotoxicity testing among populations of Thoroughbred and Standardbred horses, including animals affected with equine sarcoid and laminitis. A highly significant association is described between the presence or history of sarcoid lesions in Thoroughbreds and the expression of the major histocompatibility complex (MHC)-encoded antigens, W3 and B1. No association was found between antigenic expression frequencies and laminitis in either breed. These findings suggest that a strong relationship exists between the equine MHC and a predisposition to sarcoid.
Meredith
D
D
Elser
A H
AH
Wolf
B
B
Soma
L R
LR
Donawick
W J
WJ
Lazary
S
S
D000818:Animals; D000954:Antigens, Surface / Q000145:classification / Q000235:genetics / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D006734:Horse Diseases / Q000235:genetics* / Q000276:immunology; D006736:Horses / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D012507:Sarcoidosis / Q000276:immunology / Q000662:veterinary*
D000954:Antigens, Surface