Undifferentiated sarcomas induced in Syrian hamsters by subcutaneous injection of diethylstilbestrol.
The carcinogenic effects of weekly subcutaneous injections of dimethylnitrosamine (NDMA: 0.05 of the LD50) and diethylstilbestrol (DES: 1.5 mg/kg body wt) or a combination of both carcinogens were studied in 64 Syrian hamsters. There was no additional tumorigenic effect on NDMA-induced liver tumours in hamsters which received DES treatment prior to NDMA treatment. In contrast to the previously reported DES effects, 72% of the DES-treated hamsters unexpectedly developed undifferentiated sarcomas around the interscapular injection site. This finding suggests a local carcinogenicity of DES, which might not be related to its hormonal effects.
Ernst
H
H
Riebe
M
M
Mohr
U
U
D000818:Animals; D003043:Cocarcinogenesis; D006224:Cricetinae; D004054:Diethylstilbestrol / Q000633:toxicity*; D004128:Dimethylnitrosamine; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D008647:Mesocricetus; D012509:Sarcoma / Q000139:chemically induced* / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology
D004054:Diethylstilbestrol; D004128:Dimethylnitrosamine