Inhibitors of sterol synthesis. Effect of dietary 5 alpha-cholest-8(14)-en-3 beta-ol-15-one on ACAT activity of jejunal microsomes of the rat.
Dietary administration (0.1% in a chow diet for 8 days) of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of sterol biosynthesis with marked hypocholesterolemic action, to rats caused a 77% reduction in the levels of acyl co-enzyme A:cholesterol acyl transferase activity of jejunal microsomes relative to those observed in pair-fed control animals. No differences were observed in mean levels of cholesterol concentration in jejunal microsomes of experimental and pair-fed control animals.
Needleman
D H
DH
Department of Biochemistry, Rice University, Houston, TX 77251.
Strong
K
K
Stemke
K A
KA
Brabson
J S
JS
Kisic
A
A
Schroepfer
G J
GJ
D000818:Animals; D002782:Cholestenes / Q000494:pharmacology*; D002783:Cholestenones / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism; D004041:Dietary Fats / Q000494:pharmacology; D007408:Intestinal Absorption; D007583:Jejunum / Q000201:enzymology; D008297:Male; D008861:Microsomes / Q000201:enzymology; D051381:Rats; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*; D013261:Sterols / Q000096:biosynthesis*
D002782:Cholestenes; D002783:Cholestenones; D004041:Dietary Fats; D013261:Sterols; C015073:cholest-8(14)-en-3-ol-15-one; D002784:Cholesterol; D002785:Sterol O-Acyltransferase