Superselective intracerebral chemotherapy of malignant tumours with BCNU. Neuroradiological considerations.
Early experience shows that: Superselective intra-arterial catheterization above the ophthalmic artery minimizes the orbital complications. Catheterization in a distal branch may lead to the non-infusion of a part of the tumor territory. A much higher concentration of the drug is achieved by superselective intra-arterial infusion than by intravenous injection. Longer infusions seem more efficacious than bolus injection. Early trapping of the drug appears to be essential for therapeutic efficacy.
Théron
J
J
Villemure
J G
JG
Worthington
C
C
Tyler
J L
JL
D001812:Blood-Brain Barrier; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002330:Carmustine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D002343:Carotid Artery, Internal; D002404:Catheterization / Q000009:adverse effects / Q000379:methods; D002533:Cerebral Angiography; D005910:Glioma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007269:Injections, Intra-Arterial; D009336:Necrosis; D014057:Tomography, X-Ray Computed; D014786:Vision Disorders / Q000139:chemically induced
D002330:Carmustine