IgG and IgE antibody patterns after immunotherapy with monomethoxy polyethyleneglycol modified honey bee venom.
Antibody responses to honey bee venom (HBV) were studied in 13 patients during a 4-month course of immunotherapy with monomethoxy polyethyleneglycol (mPEG) modified venom. There was a rise of HBV-specific IgG antibodies as measured by IgG-RAST in all patients and a slight decrease of IgE antibody in most of them. The IgG-antibody responses during mPEG-HBV treatment as examined by crossed radioimmunoelectrophoresis were directed to phospholipase A, hyaluronidase, acid phosphatase and to another allergen, antigen 1. Thus, despite a high degree of mPEG-modification of HBV, the immunogenicity of the most important HBV allergens was retained.
S L
SL
Nordvall
T
T
Uhlin
S
S
Ohman
J
J
Björkander
H J
HJ
Malling
B
B
Weeke
S
S
Dreborg
A
A
Lanner
R
R
Einarsson
D000328:Adult; D000485:Allergens; D001514:Bee Venoms / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006967:Hypersensitivity; D007123:Immunoelectrophoresis, Two-Dimensional; D007073:Immunoglobulin E / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007167:Immunotherapy; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D011863:Radioimmunoassay
D000485:Allergens; D001514:Bee Venoms; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol