[Change in the adhesiveness of polymorphonuclear neutrophilic granulocytes by the intravenous anesthetics midazolam and ketamine].
The influence of midazolam and ketamine on polymorphonuclear neutrophil granulocyte (PMN) adherence was investigated in vitro by using nylon fiber columns. Both a concentration of 1.0 microgram midazolam/ml blood and 0.2 microgram/ml caused a reduction of adherence. This decrease was significant (p less than 0.05) in the case of the higher dosage. The two concentrations of ketamine used (1.3 micrograms/ml resp. 0.5 microgram/ml) produced a significant reduction of adherence too. Thus both anesthetic agents are able to impair PMN function in vitro dose-dependently. This feature is possibly related to increased risk of postoperative bacterial infection. Further studies concerning this problem should be conducted.
Krumholz
W
W
Abteilung Anästhesiologie und operative Intensivmedizin, Klinikum der Justus-Liebig-Universität Giessen.
Käbisch
S
S
Biscoping
J
J
Hempelman
G
G
D000293:Adolescent; D000328:Adult; D002448:Cell Adhesion / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007649:Ketamine / Q000633:toxicity*; D008297:Male; D008874:Midazolam / Q000633:toxicity*; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects*
D007649:Ketamine; D008874:Midazolam
Uber Veränderung der Adhärenz polymorphkerniger neutrophiler Granulozyten durch die intravenösen Anästhetika Midazolam und Ketamin.