[Spectral and coherence EEG analysis of rats differing in the level of seizure readiness].
The resting EEGs of several brain structures (motor and visual cortex, caudate nucleus and intralaminar thalamic nuclei) were submitted to spectral and coherence computer analyses in two rat strains. Genetically predisposed to convulsive state KM rats were shown to differ from nonpredisposed Wistar rats in EEG spectral properties. KM rats EEG pattern was characterized by increase of low frequencies (1-2 Hz) power and decrease of faster activity (5-12 Hz) power in cortical spectrograms as well as by decrease of caudate nucleus EEG absolute power. The coherence value between cortical or subcortical structures at below 4 Hz was intensified in KM rats. Reinforcement of cortical auto-oscillating properties manifested by ECoG synchronization in cortical-thalamic resonance interaction as well as weakening of striatal inhibitory system may constitute neurophysiological mechanisms of enhanced convulsive readiness. The probable role of mediator imbalance in these mechanisms is discussed.
Medvedev
A V
AV
Kuznetsova
G D
GD
D000161:Acoustic Stimulation; D000818:Animals; D001931:Brain Mapping; D003700:Delta Rhythm; D004198:Disease Susceptibility; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*; D012640:Seizures / Q000503:physiopathology*; D013826:Theta Rhythm
Spektral'nyĭ i kogerentnyĭ analiz EEG krys, razlichaiushchikhsia po urovniu sudorozhnoĭ gotovnosti.