Effects of dyes (indigo carmine, metanil yellow, fast green FCF) and nitrite in vivo on bone marrow chromosomes of mice.
Effects of 3 dyes in combination with nitrite were studied on bone marrow chromosomes of mice following prolonged oral treatment. The dyes were namely, Indigo Carmine and Metanil Yellow, both of which contain a secondary amino group, and Fast Green FCF, which has a tertiary amino group. All dyes produced aberrations but Metanil Yellow showed stronger clastogenic activity than Fast Green FCF and Indigo Carmine. Nitrite alone also induced strong clastogenic activity. A combination of dye and nitrite half the normal concentrations produced synergistic effects, which may be ascribed to the formation of nitrosamines.
Giri
A K
AK
Banerjee
T S
TS
Talukder
G
G
Sharma
A
A
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D004396:Coloring Agents / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D051379:Mice; D009573:Nitrites / Q000494:pharmacology*
D004396:Coloring Agents; D009573:Nitrites