Prevention of postmetrizamide myelographic seizures in dogs, using 5% dextrose solution.
Diuresis by IV administration of 5% dextrose in a balanced electrolyte solution (BES) reduced the frequency of occurrence of postmyelographic seizures in dogs. In the first study, a single myelogram was obtained in 8 dogs without dextrose diuresis. Two of these dogs weighed greater than 15 kg and both had seizures after metrizamide myelography. The remaining 6 dogs weighed less than 15 kg and only 2 had seizures. Greater body weight may have increased the risk of postmyelographic convulsions. In a crossover study, myelograms were obtained in 12 dogs weighing 20 to 31 kg. Six dogs were given 5% dextrose in BES (20 ml/kg of body weight/hr [diuresed]) and 6 were given BES alone (10 ml/kg/hr [not diuresed]). When myelography was repeated 10 days later, the 6 dogs that had been given 5% dextrose in BES were given BES only and the 6 dogs that had been given BES alone were given 5% dextrose in BES. The frequency of convulsions after metrizamide myelography was lower when dogs were given dextrose (33%) than when they were not (100%).
Tamas
P M
PM
Walker
M A
MA
Paddleford
R R
RR
Tinkel
S R
SR
D000818:Animals; D004231:Diuresis / Q000187:drug effects; D004283:Dog Diseases / Q000139:chemically induced* / Q000517:prevention & control; D004285:Dogs; D005260:Female; D005947:Glucose / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008793:Metrizamide / Q000009:adverse effects*; D009192:Myelography / Q000009:adverse effects / Q000662:veterinary*; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary*
D005947:Glucose; D008793:Metrizamide