Hepatic uptake of gluconeogenic substrates in late-pregnant and mid-lactating rats.
Lactate uptake by liver is markedly increased in late-pregnant and mid-lactating rats without concomitant changes in its availability. Glycerol contribution to the liver 3-C unit uptake is only significant at term gestation (50% of lactate uptake) but almost negligible at mid-lactation (10% of lactate uptake). Pyruvate is only taken up by the liver of 15-day lactating rats. As a general trend, the livers of either pregnant or lactating rats are provided with an enhanced capacity to take up gluconeogenic substrates.
Department de Bioquímica i Fisiologia, Universitat de Barcelona, Facultal de Biologia, Spain.
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J
Casado
X
X
Remesar
M
M
Pastor-Anglada
D000818:Animals; D005260:Female; D005943:Gluconeogenesis; D005990:Glycerol / Q000378:metabolism; D007773:Lactates / Q000378:metabolism*; D007774:Lactation / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008102:Liver Circulation; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D007773:Lactates; D011773:Pyruvates; D005990:Glycerol