[Effect of perfluorodecalin and perfluorotributylamine on the liver cytochrome P-450 system].
The effect of a single intraperitoneal injection of perfluorodecaline (0.5 ml) and perfluorotributylamine on the cytochrome P-450-dependent monooxygenase system of male hybrid mouse (CBA X C57Bl) liver was studied. It was shown that perfluorodecaline is a potent inducer of the cytochrome P-450 system in the liver. The sharp increase of the cytochrome P-450 content and of the enzymatic activity was observed within 5 months. The biological effect of perfluorotributylamine on the monooxygenase system of the liver was much less pronounced. A slight inhibition of the cytochrome P-450 system was observed at short times after the injection followed by its slight stimulation after 2 weeks; 30 days thereafter all the parameters under study returned to control values.
Khlopushina
T G
TG
Kovalev
I E
IE
Lysenkova
E M
EM
D000818:Animals; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D005466:Fluorocarbons / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D013997:Time Factors
D065607:Cytochrome P-450 Enzyme Inhibitors; D005466:Fluorocarbons; C008807:perfluorotributylamine; C008805:perfluorodecalin; D003577:Cytochrome P-450 Enzyme System
Vliianie perftordekalina i perftortributilamina na sistemu cytokhroma P-450 pecheni.