Cardioprotective actions of a new calcium channel blocker in acute myocardial ischemia.
The ability of anipamil, a calcium channel blocker, to protect ischemic myocardial tissue was investigated in pentobarbital anesthetized cats. Two bolus injections of anipamil (1.0 mg/kg i.v.) or their vehicle (i.e., 95% ethanol) were given 30 and 150 min post-ligation of the left anterior descending coronary artery. Anipamil significantly reduced the elevated S-T segment elevation and T wave amplitude suggesting a moderating influence on cellular ischemia. The drug also significantly blunted the loss in myocardial creatine kinase activity and amino-nitrogen concentrations from ischemic myocardial tissue, compared to cats receiving only the vehicle. These changes are suggestive of a cardioprotective effect of this calcium channel blocker. Since no significant change in the pressure rate index was seen with anipamil, a decrease in myocardial oxygen demand does not appear to be the major mechanism of the cardioprotective action of the agent. Therefore, anipamil protected the heart from ischemic damage, possibly by a direct cytoprotective action.
M E
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Brezinski
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H
Darius
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Lefer
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002415:Cats; D003327:Coronary Disease / Q000188:drug therapy*; D003331:Coronary Vessels / Q000187:drug effects / Q000473:pathology; D003402:Creatine Kinase / Q000378:metabolism; D004562:Electrocardiography; D007269:Injections, Intra-Arterial; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D011437:Propylamines / Q000008:administration & dosage / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D011437:Propylamines; C045313:anipamil; D003402:Creatine Kinase