Ex vivo interactions and surface property relationships of polyetherurethanes.
Despite the use of polyurethanes in a number of blood-contacting applications, little is known about the contributing effects of the various polyurethane components in thrombogenesis. In order to investigate blood-polyurethane interactions, a number of different polyurethanes were examined in an acute canine ex vivo series shunt experiment. Multiprobe surface characterization techniques, including contact angle measurements, ESCA, ATR-IR, and SEM were used to obtain surface property information on the materials studied. The polyurethanes examined included several with different soft segment types, a series of materials with different hard segment diisocyanates and chain extenders, a series consisting of the same polymer cast from different solvents, a zwitterionomer, and a hard segment analog. Two commercial urethanes were also examined, and the effect of methanol extraction on these materials was studied. The blood-contact and surface characterization results indicated that both the surface concentration and type of hard segment were of importance in determining blood response. The relative concentration of hard segment on the polymer surface was found to affect the observed blood-material interaction, although the extent of this effect was found to depend on the hard and soft segment components of the copolymer system. Both the surface properties and thrombogenicity of a particular polyurethane were changed by casting from different solvents, indicating the need to optimize and control fabrication conditions. Methanol extraction was found to improve the thromboresistance of the commercial polyurethanes.
Lelah
M D
MD
Grasel
T G
TG
Pierce
J A
JA
Cooper
S L
SL
D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D001672:Biocompatible Materials / Q000009:adverse effects*; D001769:Blood; D004285:Dogs; D005069:Evaluation Studies as Topic; D005340:Fibrinogen / Q000378:metabolism; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness; D011140:Polyurethanes / Q000009:adverse effects*; D012997:Solvents; D013499:Surface Properties; D013927:Thrombosis / Q000209:etiology*
D001672:Biocompatible Materials; D011140:Polyurethanes; D012997:Solvents; C115016:polyetherurethane; D005340:Fibrinogen