The responsiveness to (1-24) ACTH of Mongolian gerbil adrenals superfused in vitro as a function of basal secretion.
Wide variations have been found in the responsiveness to (1-24)ACTH of Mongolian gerbil adrenal glands superfused in vitro. These variations were not correlated to corticosteroid plasma levels or to adrenal weights. In contrast, (1-24)ACTH-stimulated secretion greatly depended on basal in vitro secretion (quarters: r = 0.97, p less than 0.01; slices: r = 0.90, p less than 0.001) indicating that the fine adjustment of basal corticosteroidogenesis forms an important part of the regulatory mechanisms modulating (1-24)ACTH-stimulated corticosteroid secretion in vitro.
Fenske
M
M
Universität Bayreuth, Federal Republic of Germany.
D000305:Adrenal Cortex Hormones / Q000378:metabolism*; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D003366:Cosyntropin / Q000494:pharmacology*; D005849:Gerbillinae / Q000502:physiology*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D010477:Perfusion; D014418:Tupaiidae / Q000502:physiology*
D000305:Adrenal Cortex Hormones; D003366:Cosyntropin