[Age-related changes in glycolysis and levels of modulators of oxygen transport function of hemoglobin in human erythrocytes].
The glycolysis rate and the amount of the acid-transport hemoglobin function modulators (diphosphoglycerate (2,3-DPG), ATP, glutathione, chlorides) in human erythrocytes are studied under the effect of age changes. It is shown that the glycolysis rate and the content of ATP decrease under ageing by 16% and 21%, respectively. The concentration of 2,3-DPG lowers insignificantly (by 8%). At the same time it is established that the amount of reduced glutathione in erythrocytes of middle-aged and old people enhances by 25-29% and that of chlorine ions by 23-24%. The revealed changes in the concentration of modulators of the hemoglobin affinity to oxygen with ageing are, probably, one of reasons of the oxyhemoglobin dissociation increase.
Bogatskaia
L N
LN
Korkushko
O V
OV
Pisaruk
A V
AV
D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate / Q000097:blood; D000328:Adult; D000368:Aged; D000375:Aging; D002712:Chlorides / Q000097:blood; D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000378:metabolism*
D002712:Chlorides; D004163:Diphosphoglyceric Acids; D010108:Oxyhemoglobins; D019794:2,3-Diphosphoglycerate; D000255:Adenosine Triphosphate; D010100:Oxygen
Vozrastnye izmeneniia glikoliza i soderzhaniia moduliatorov kislorodtransportnoĭ funktsii gemoglobina v éritrotsitakh cheloveka.