[Effect of tiropramide on solid gastric emptying time in man].
The influence of Thyropramide, a recently developed spasmolytic on the gastric emptying times of a solid meal was assessed in 10 healthy subjects aged 23-54. Thyropramide (300 mg per diem for 3 days per os) does not significantly modify gastric emptying time compared to the placebo though a slight average increase in T 1/2 was noted. No side effects were noted during the study. Thyropramide therefore appears to have a spasmolytic effect on the large intestine without in any way influence the stomach either proximally or distally.
Corinaldesi
R
R
Stanghellini
V
V
Zarabini
G E
GE
Raiti
C
C
Rea
E
E
Salgemini
R
R
Giacomoni
E
E
Barbara
L
L
D000328:Adult; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D007420:Intestine, Large / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology*; D014443:Tyrosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D010276:Parasympatholytics; D014443:Tyrosine; C031173:tiropramide
Effetto della Tiropramide sul tempo di svuotamento gastrico dei solidi, nell'uomo.