Effects of corticosterone on shaking and seizure behavior induced by deep prepyriform cortex kindling.
The influence of adrenocorticosteroids on seizures and wet dog shakes (WDS) induced by deep prepyriform cortex kindling was studied by bilateral adrenalectomy and corticosterone replacement. The rate of kindling, latency to the onset and duration of motor seizures were not significantly affected by adrenalectomy or corticosterone treatment. However, the number of WDS observed after stage 5 seizures was reduced in adrenalectomized animals and it was not restored until 3 h following corticosterone replacement. This delay in onset of action suggests that the effects of adrenocorticosteroids and/or ACTH on WDS may be mediated by an indirect mechanism.
Laboratory of Behavioral and Neurological Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
P H
PH
Lee
D Y
DY
Zhao
C L
CL
Mitchell
J S
JS
Hong
D000315:Adrenalectomy; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002540:Cerebral Cortex / Q000502:physiology*; D003345:Corticosterone / Q000494:pharmacology*; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012640:Seizures / Q000503:physiopathology*
D003345:Corticosterone