Metabolism and excretion of gallium arsenide and arsenic oxides by hamsters following intratracheal instillation.
The increasing use of gallium arsenide (GaAs) in the electronics industry has produced the need for pharmacokinetic and toxicologic data on GaAs. The disposition in male Syrian golden hamsters (n = 4) following intratracheal instillation of GaAs (mean volume diameter 5.8 micron), arsenic (III) oxide (arsenite), and arsenic (V) oxide (arsenate) at a dose of 5 mg/kg body weight was examined. Blood, kidney, liver, and lung samples were collected at 1, 2, and 4 days after administration. Excreta were collected daily. Urinary metabolite profiles were determined after separation on a mixed anion-cation-exchange column. Total As content was analyzed by direct hydride flame atomic absorption spectrophotometry after digestion. Arsenic blood levels after GaAs, arsenite, and arsenate administration were 0.185 +/- 0.041, 0.596 +/- 0.117, and 0.310 +/- 0.045 ppm, respectively, after Day 1. Arsenic blood levels after GaAs administration increased to 0.279 +/- 0.021 ppm on Day 2 indicating continued absorption while levels decreased for the arsenite and arsenate groups. At Day 1 the liver contained 0.565 +/- 0.036, 2.62 +/- 0.26, and 0.579 +/- 0.144% of the arsenic dose of GaAs, arsenite, and arsenate, respectively. The arsenite and arsenate were rapidly excreted in the urine with almost half the dose appearing after 4 days; in contrast, only about 5% of the GaAs was found at the corresponding time. Total recoveries, as arsenic equivalents, for the three compounds were between 75 and 80%. Ratios of the two major urinary metabolites (dimethylarsinic acid/total inorganic As species) were 1.41, 1.71, and 0.983 for GaAs, arsenite, and arsenate, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Rosner
M H
MH
Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson 85721.
Carter
D E
DE
D000042:Absorption; D000818:Animals; D001149:Arsenates / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D001151:Arsenic / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D001152:Arsenicals; D018053:Arsenites; D006224:Cricetinae; D005708:Gallium / Q000008:administration & dosage / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D017670:Sodium Compounds; D014018:Tissue Distribution
D001149:Arsenates; D001152:Arsenicals; D018053:Arsenites; D017670:Sodium Compounds; C043055:gallium arsenide; C017947:sodium arsenite; C009277:sodium arsenate; D005708:Gallium; D001151:Arsenic