[Characteristics of the complex effect of benzo(a)pyrene on the body after simultaneous administration via the respiratory organs and digestive tract].
The data on the carcinogenic activity of different benz(a)pyrene (BP) doses depending on the mode of administration are presented. Carcinogen was introduced to 418 female mice in the doses from 0.5 to 10 mg intratracheally, perorally or simultaneously. It is established that the complex administration of BP is more dangerous as compared with the intratracheal and with the peroral one, which was indicated by an increase of the tumour incidence and in a shortening of the latent period. Calculation of the contribution or a share of the complex dose from the isoeffective value under isolated entry of BP has shown that the coefficient of complex action is 0.6, that evidences for the effect of the dose potentiating.
I A
IA
Chernichenko
D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D001564:Benzo(a)pyrene / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology
D001564:Benzo(a)pyrene
Osobennosti kompleksnogo vozdeĭstviia benz(a)pirena na organizm pri odnovremennom postuplenii cherez organy dykhaniia i pishchevaritel'nyĭ trakt.