The effect of exercise on secretory and natural immunity.
Secretory immunity. 1. Intense endurance exercise suppresses salivary immunoglobulins. The exercise-induced decrease is specific for the secretory antibodies IgA and IgM. 2. The suppression of secretory Ig is transitory, lasting at least one hour, and returning to pre-exercise levels by 24 hours after a single bout of severe exercise. These results suggest that anecdotal statements by athletes and their coaches of an increased susceptibility to upper respiratory infection after severe exercise could be related to changes in secretory immunity. Natural immunity. 1. Natural killer activity of PBL is suppressed one hour after intense endurance exercise. This effect is transitory, since activity returns to pre-exercise levels by 24 hours after a single bout of exercise. 2. The decrease in NK lytic activity is due to a decrease in the percentage of NK cells (Leu-11a+ cells). When NK cell activity is expressed on a per cell basis, it appears that activity is enhanced after exercise.
Department of Cell Biology, University of New Mexico School of Medicine, Albuquerque.
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Tomasi
D000328:Adult; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D007071:Immunoglobulin A, Secretory / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D005082:Physical Exertion; D012463:Saliva / Q000276:immunology*; D013178:Sports Medicine; D013997:Time Factors
D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007075:Immunoglobulin M