A controlled release form of 16,16-dimethyl-trans-delta 2-PGE, methyl ester for early abortion.
The termination of early pregnancy (less than 56 days amenorrhoea) has been investigated using 16,16-dimethyl-trans-delta 2-PGE, methyl ester in a controlled release preparation. The onset of crampy abdominal pain was seen after 270 +/- 39 minutes and bleeding occurred after 603 +/- 95 minutes. Two (15%) patients required no pain relief during treatment, however 5 (38%) requested oral analgesia, and in 6 (46%) individuals the pain was severe enough to warrant parenteral opiates. The overall success rate for complete abortion was 85%. No serious adverse effects were seen, but vomiting occurred in 2 (15%) women, and diarrhoea in 3 (23%). Although the use of this prostaglandin analogue in slow release form provides an effective treatment method for early abortion using a reduced total dose of prostaglandin, the acceptability of the drug as an agent for menstrual induction continues to be limited by the occurrence of troublesome gastro-intestinal side effects.
Cameron
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Baird
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D000005:Abdomen; D000019:Abortifacient Agents / Q000008:administration & dosage*; D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage* / Q000009:adverse effects; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D003692:Delayed-Action Preparations; D003967:Diarrhea / Q000139:chemically induced; D004107:Dilatation and Curettage; D005260:Female; D006801:Humans; D010146:Pain / Q000139:chemically induced; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014592:Uterine Hemorrhage / Q000209:etiology; D014839:Vomiting / Q000139:chemically induced
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D003692:Delayed-Action Preparations; C021182:gemeprost; D000527:Alprostadil