Postlactational changes in cadmium retention in mice orally exposed to cadmium during pregnancy and lactation.
Mice were continuously exposed to 109Cd in drinking water (0.03 microCi/ml; 0.11 ppb total cadmium) during pregnancy and lactation. After cessation of exposure, 109Cd retention and distribution were examined during a 4-week postlactational period. At the start of the postlactational period (0 time), the fraction of oral 109Cd retained by the dams was 2.4 times greater than that retained by similarly exposed nonpregnant mice. 109Cd concentrations at 0 time were greater in the dams than in the nonpregnant mice in kidney (5-fold), liver (2.6-fold), mammary tissue (greater than 28-fold), and duodenum (13-fold). No changes in 109Cd content of the whole body (minus gastrointestinal tract) occurred during the 4 weeks after cessation of exposure in either the dams or the nonpregnant mice; i.e., pregnancy-dependent increases in 109Cd contents of individual organs were maintained during the 4 weeks of observation. An indication of translocation of 109Cd from liver to kidney was observed in the dams but not in the nonpregnant mice. 109Cd concentrations in the mammary tissue of the dams increased 2-fold during the postlactational period concomitant with a 3-fold decrease in mammary tissue mass. 109Cd in the duodenum of the pregnant/lactating mice decreased, with a half-life of 14 days. Results indicate that multiparous women exposed to environmental levels of cadmium may take up and retain in their kidneys, livers, and mammary tissue a greater fraction of their dietary cadmium than women with few or no children. Such results may bear on the etiology of Itai-Itai disease, a disease of the skeleton potentially related to oral cadmium exposure, with an incidence predominantly among postmenopausal women with a history of multiple childbirths.
Bhattacharyya
M H
MH
Sellers
D A
DA
Peterson
D P
DP
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000378:metabolism* / Q000494:pharmacology; D005260:Female; D007774:Lactation; D051379:Mice; D011247:Pregnancy; D011868:Radioisotopes; D014018:Tissue Distribution
D011868:Radioisotopes; D002104:Cadmium