Cadmium content in selected rat tissues following treatments with cadmium chloride and/or gamma radiation.
This study was conducted to determine concentrations of cadmium (Cd) in various rat tissues; radiation effectiveness on Cd concentrations in rat tissues; and Cd effectiveness when radiation was applied as the second insult. Animals were subjected to Cd over a 29-day period and on Day 30 were exposed to an acute dose of 60Co gamma-ray. Rats were killed on Day 1, 7, or 21 following irradiation. Cd concentrations were determined by flame spectroscopy. Rats injected with Cd alone or Cd in combination with radiation showed a dose-dependent accumulation and retention of the metal in the liver and kidney over the intervals to sacrifice. Significantly smaller amounts of the metal were seen in the spleen, intestine, stomach, heart, testis, lung, blood, brain, and muscle. Generally, Cd did not afford protection against radiation in the tissues studied. Radiation, when used singly or as a coinsult with Cd, did not significantly alter the concentrations of Cd in any of the tissues studied except the heart, in which it contributed to the clearance of Cd. No synergistic or antagonistic effects were observed between Cd and ionizing radiation in any of the other tissues studied.
Y R
YR
Kundomal
R M
RM
Morgan
E W
EW
Hupp
D000818:Animals; D002104:Cadmium / Q000378:metabolism*; D019256:Cadmium Chloride; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D003037:Cobalt Radioisotopes; D002104:Cadmium; D019256:Cadmium Chloride