The effect of normovolaemic haemodilution on the early patency rate of small calibre vascular prostheses studied in a new animal model.
A new animal model has been developed to study early thrombosis in small calibre vascular prostheses. It consists of an ePTFE graft 2 cm long and of 3mm internal diameter inserted into a rabbit abdominal aorta in which the distal run-off is reduced by narrowing both common iliac arteries using clips with a standard gap. Scanning electron microscopy and in vivo gamma imaging of the graft using labelled autologous platelets showed that, as in the human, platelets played a primary role in the model graft thrombosis. This model was used to study the effect of haemodilution on early graft patency. Moderate normovolaemic haemodilution dramatically improved the early patency rate.
M S
MS
Mahir
J W
JW
Hynd
P T
PT
Flute
J A
JA
Dormandy
D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001792:Blood Platelets / Q000502:physiology; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D001809:Blood Viscosity; D004195:Disease Models, Animal; D006083:Graft Occlusion, Vascular / Q000517:prevention & control; D006438:Hemodilution; D008297:Male; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D013927:Thrombosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control