Evaluation of circulating immune complexes (C.I.C.) in endometrial cancer.
We evaluated the presence of CIC in 32 patients with histological proven cancer of endometrium: 23 stage IA or IB (i.e. localized disease), 9 in stage II or III (i.e. advanced disease). The determination of CIC was done at the time of the diagnosis before the patients underwent any surgical or medical therapy. The presence of CIC was demonstrated in 17% (4/23) of the patients with localized disease and in 56% (9/9) of the patients with more advanced disease. Our findings indicate that the presence of CIC is higher in patients with advanced endometrial carcinoma (stage II, III), than in those suffering of a more limited disease (stage IA, IB) and this seems could be consistent with a possible role in modulating the immune response against tumour itself.
P
P
Benedetti Panici
P
P
Di Roberto
G
G
Scambia
R
R
Cauda
V
V
Laghi
S
S
Mancuso
A
A
Bompiani
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis*; D003181:Complement C4 / Q000032:analysis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008875:Middle Aged; D009367:Neoplasm Staging; D011092:Polyethylene Glycols; D014594:Uterine Neoplasms / Q000276:immunology* / Q000473:pathology
D000936:Antigen-Antibody Complex; D003181:Complement C4; D007074:Immunoglobulin G; D011092:Polyethylene Glycols