Does prior instillation of a topical anesthetic enhance the effect of tropicamide?
Preinstillation of a topical anesthetic has been reported to increase the effect of subsequently applied mydriatics. We examined the effect of instilling 1 drop of proparacaine hydrochloride (0.5%) before applying 1 drop of tropicamide (1%). The results show that preanesthesia prolongs the mydriatic and the cycloplegic effects of tropicamide in eyes with either lightly or more heavily pigmented irides.
J A
JA
Mordi
W M
WM
Lyle
G Y
GY
Mousa
D000065:Accommodation, Ocular / Q000187:drug effects; D000328:Adult; D000779:Anesthetics, Local / Q000494:pharmacology*; D004357:Drug Synergism; D006801:Humans; D011292:Premedication; D011430:Propoxycaine / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D012025:Reflex, Pupillary / Q000187:drug effects*; D014331:Tropicamide / Q000494:pharmacology*
D000779:Anesthetics, Local; D011725:Pyridines; C005717:proxymetacaine; D011430:Propoxycaine; D014331:Tropicamide