Influence of mixed-ligand complexes on retention and distribution of radioniobium in mice.
The individual effects of desferrioxamine B (DFOA), Na3Ca diethylenetriaminepentaacetic acid (DTPA), Na-salicylate, DL-penicillamine, and 2-aminoethylisothiouronium bromide hydrobromide, as well as the effect of mixed-ligand treatment on the retention and elimination of 95Nb in mice have been examined. It was found that 95Nb could easily be mobilized by a single dose of DFOA, but the best result was obtained with the DFOA and DTPA combination. Mixed-ligand treatment did not change the deposition characteristics and translocation kinetics of 95Nb.
Frédéric Joliot-Curie, National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary.
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A
Gachályi
J
J
Naményi
I
I
Szegedi
L P
LP
Varga
D000818:Animals; D002614:Chelating Agents / Q000008:administration & dosage* / Q000494:pharmacology; D003666:Decontamination / Q000379:methods; D003676:Deferoxamine / Q000008:administration & dosage / Q000494:pharmacology; D004359:Drug Therapy, Combination; D008297:Male; D051379:Mice; D009556:Niobium / Q000493:pharmacokinetics*; D010396:Penicillamine / Q000008:administration & dosage / Q000494:pharmacology; D004369:Pentetic Acid / Q000008:administration & dosage / Q000494:pharmacology; D011868:Radioisotopes / Q000493:pharmacokinetics*; D012980:Sodium Salicylate / Q000008:administration & dosage / Q000494:pharmacology; D000338:beta-Aminoethyl Isothiourea / Q000008:administration & dosage / Q000494:pharmacology
D002614:Chelating Agents; D011868:Radioisotopes; D009556:Niobium; D000338:beta-Aminoethyl Isothiourea; D004369:Pentetic Acid; D010396:Penicillamine; D003676:Deferoxamine; D012980:Sodium Salicylate