The locus ordering problem.
Studies of phenotypes defined by codominant alleles at two or more loci in three-generation families allow haplotypes to be deduced. These data are easily summarized by the Mendelian convention of upper and lower case, with case defining phase rather than nature. In two-generation families haplotypes may be inferred with high precision for closely linked loci even if an allele at one locus is recessive. Coding procedures are discussed and a simple solution to inferring the most likely order of three or more loci, and defining its likelihood compared with other orders, is presented.
Genetics Laboratory, Biochemistry Department, Oxford.
J H
JH
Edwards
D002874:Chromosome Mapping; D008040:Genetic Linkage; D006239:Haplotypes; D008126:Lod Score; D010641:Phenotype; D011995:Recombination, Genetic; D013223:Statistics as Topic