[Hypotrichosis congenita hereditaria Marie Unna with Ehlers-Danlos syndrome and atopy].
A family suffering from hypotrichosis congenita hereditaria Marie Unna is reported (16 members affected in five generations). The typical symptoms of this autosomal dominant syndrome were found: pili torti, canaliculi et trianguli, inborn generalized hypotrichosis, later on resulting in alopecia of the androgenetic type. A 19-year-old female patient with hyperandrogenemia was treated with cyproterone acetate and ethinyl estradiol. Furthermore, hypotrichosis was associated with Ehlers-Danlos syndrome and atopic symptoms in the last three generations of the family. There does not seem to be any genetic connection between the syndromes however.
Mende
B
B
Hautklinik und Poliklinik, Rheinischen Friedrich-Wilhelms-Universität Bonn.
Kreysel
H W
HW
D000328:Adult; D000505:Alopecia / Q000235:genetics*; D003876:Dermatitis, Atopic / Q000235:genetics; D004535:Ehlers-Danlos Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D007039:Hypotrichosis / Q000235:genetics*; D010375:Pedigree
Hypotrichosis congenita hereditaria Marie Unna mit Ehlers-Danlos-Syndrom und Atopie.