[Dose-dependent telenzepine inhibition of the secretion of human gastric acid stimulated by sham feeding and saliva].
The effect of graded doses of the new antimuscarinic agent telenzepine on human gastric secretion has been studied in a double-blind placebo-controlled trial in nine healthy volunteers. Over a period of 60 minutes basal acid output as well as acid response to sham feeding was examined. Telenzepine reduced dose-dependently basal acid secretion: This parameter was inhibited with 1 mg by 2%, with 2 mg by 37%, with 3 mg by 53% and with 5 mg by 76%, respectively. The corresponding values for stimulated acid secretion were 16%, 34%, 40% and 57%, respectively. The reduction of basal and stimulated acid secretion was statistically significant (p less than 0.05) following the two larger telenzepine doses. Production of saliva was inhibited by 9%, 21%, 28% and 48%, respectively. The latter reaching statistical significance (p less than 0.05).
Müller
P
P
Dammann
H G
HG
Simon
B
B
D000328:Adult; D001570:Benzodiazepinones / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004435:Eating; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D010890:Pirenzepine / Q000031:analogs & derivatives*; D011897:Random Allocation; D012472:Salivation / Q000187:drug effects*
D001570:Benzodiazepinones; D010276:Parasympatholytics; C046338:telenzepine; D010890:Pirenzepine
Telenzepin hemmt dosisabhängig die durch Scheinfütterung stimulierte menschliche Säure- und Speichelsekretion.