Vaccine-associated contact paralytic poliomyelitis with atypical neurological presentation.
Paralytic poliomyelitis presenting with quadriparesis, transient encephalitis and bulbar symptoms in 2 patients in close contact with recently vaccinated children with trivalent live oral polio vaccine is described. Symmetrical lower motor neuron involvement of deltoid muscles with electromyographic confirmation was found. Upper motor neuron signs, with symmetrical hyperactive deep tendon reflexes developed in the lower extremities. Poliovirus Type-2 vaccine-like strain was cultured from one patient and both patients showed significant antibody titers rises to poliovirus. Attention is drawn to the possible clinical differences between vaccine associated poliomelitis and the usual features found in wild strain poliomyelitis. It is suggested that in selected cases, non-immunized contacts be given inactivated polio-vaccine when the vaccinees are immunized with the live oral-vaccine.
Department of Neurology, Assaf Harofeh Medical Center, Zerifin, Israel.
A
A
Arlazoroff
Z
Z
Bleicher
C
C
Klein
E
E
Vure
E
E
Lahat
B
B
Gross
R
R
Handsher
D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009460:Neurologic Examination; D011052:Poliomyelitis, Bulbar / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects*
D011055:Poliovirus Vaccine, Oral