Fibrinopeptide A increases after chorionic villus sampling.
Fibrinopeptide levels were measured in 20 women during transcervical chorionic villus sampling (CVS). Fibrinopeptide A, a sensitive indicator of fibrinogen cleavage by thrombin, significantly increased in five subjects, whereas there was no change in B beta peptide, an indicator of fibrinolysis. The data suggest that modest fibrin formation, uncompensated by fibrinolysis, may be induced in some women by CVS.
Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611.
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F
Al-Gailani
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Elias
J L
JL
Simpson
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D
Green
D000328:Adult; D001706:Biopsy; D002824:Chorionic Villi / Q000473:pathology*; D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen / Q000378:metabolism*; D005344:Fibrinopeptide A / Q000378:metabolism*; D005345:Fibrinopeptide B / Q000378:metabolism; D006801:Humans; D008431:Maternal-Fetal Exchange; D010446:Peptide Fragments / Q000378:metabolism; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012307:Risk Factors
D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; C033786:fibrinogen Bbeta (15-42); D005344:Fibrinopeptide A; D005345:Fibrinopeptide B; D005340:Fibrinogen