The treatment of passively transferred experimental myasthenia with anti-idiotypic antibodies.
Experimental autoimmune myasthenia gravis (EAMG) was induced in chickens by passive transfer of a monoclonal antibody (mcAb) specific for the cholinergic binding site of the acetylcholine receptor (AChR). Specific anti-idiotypes raised in rabbits against this antisite mcAb (5.5) were demonstrated to prevent the induction of EAMG by a subsequent injection of mcAb 5.5. Also, administration of anti-idiotypes against mcAb 5.5 to chickens in which EAMG has been induced by mcAb 5.5 led to a recovery from myasthenic symptoms. These results suggest that passive transfer of the appropriate anti-idiotypes may have potential in the regulation of myasthenia.
Souroujon
M C
MC
Pachner
A R
AR
Fuchs
S
S
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D002645:Chickens; D007116:Immunization, Passive; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D009157:Myasthenia Gravis / Q000276:immunology*
D007130:Immunoglobulin Idiotypes