[Effect of ascorbic acid on the induction of uterine sarcomas in mice].
Administration of ascorbic acid (0.3, 0.75 or 1.5%) in drinking water started after the treatment of female CBA mice with 1,2-dimethylhydrazine and estradiol-dipropionate inhibited the growth of uterine sarcomas. The inhibitory effect depended upon dosage to some extent. When administered together with estradiol-dipropionate to intact mice, ascorbic acid arrested uterine growth associated with estrogen treatment.
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Trukhanova
D019813:1,2-Dimethylhydrazine; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D004127:Dimethylhydrazines / Q000037:antagonists & inhibitors; D004958:Estradiol / Q000031:analogs & derivatives; D004965:Estrogen Antagonists; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D009929:Organ Size / Q000187:drug effects; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D014594:Uterine Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D014599:Uterus / Q000187:drug effects
D004127:Dimethylhydrazines; D004965:Estrogen Antagonists; D004958:Estradiol; D019813:1,2-Dimethylhydrazine; C023482:estradiol dipropionate; D001205:Ascorbic Acid
Vliianie askorbinovoĭ kisloty na induktsiiu sarkom matki u mysheĭ.