Effect of miconazole on growth and aflatoxin production by Aspergillus parasiticus.
At 5 microM, miconazole prevented the growth of Aspergillus parasiticus Speare in a number of media. Sensitivity to miconazole was increased approximately 10-fold in a medium containing glycerol. At sub-inhibitory concentrations, miconazole stimulated aflatoxin synthesis on media which normally support toxin formation. Miconazole inhibited respiration and altered mitochondrial ultrastructure, suggesting that miconazole inhibits growth and stimulates aflatoxin production by depressing mitochondrial activity.
Eastern Regional Research Center, USDA, Philadelphia, PA 19118.
R L
RL
Buchanan
S B
SB
Jones
H G
HG
Stahl
D000348:Aflatoxins / Q000096:biosynthesis*; D001230:Aspergillus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism / Q000648:ultrastructure; D003470:Culture Media; D005990:Glycerol / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008825:Miconazole / Q000494:pharmacology*; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects / Q000648:ultrastructure; D010101:Oxygen Consumption / Q000187:drug effects
D000348:Aflatoxins; D003470:Culture Media; D008825:Miconazole; D005990:Glycerol