Neutralization of alpha-bungarotoxin by monoclonal antibodies.
We have produced monoclonal antibodies against alpha-bungarotoxin from Bungarus multicinctus, and controls were performed for their specificity and monoclonal character. The antibodies protected mice against the toxic effect of alpha-bungarotoxin for a few hours to six days, depending upon the chosen antibody (in comparison to a survival time of 79 min for the standard toxin dose). Antibodies can be grouped in several sets according to their duration of protection.
Danse
J M
JM
Toussaint
J L
JL
Kempf
J
J
D000818:Animals; D000911:Antibodies, Monoclonal; D002038:Bungarotoxins / Q000037:antagonists & inhibitors* / Q000276:immunology; D004588:Electrophoresis, Cellulose Acetate; D004797:Enzyme-Linked Immunosorbent Assay; D006825:Hybridomas; D051379:Mice; D008807:Mice, Inbred BALB C; D009500:Neutralization Tests
D000911:Antibodies, Monoclonal; D002038:Bungarotoxins