[The endocrine stress-reaction to orotracheal intubation and topical anesthesia with lidocaine].
The influence of laryngoscopy and intubation with or without topical lidocaine anesthesia on the endocrine stress response was investigated in six groups of 40 orthopedic surgery patients differing in premedication and technique of lidocaine application (one- or two-step method). Controls were included without lidocaine application. Plasma levels of catecholamines (by HPLC) were measured before induction and 1, 5, and 10 min after intubation, ADH-levels (by RIA) before induction and 5 and 10 min after intubation. In addition, mean arterial pressure (MAP, MAP), HR, and the incidence of coughing and cardiac arrhythmias were observed. The statistical evaluation (analysis of variance with repeated measures on one factor) considered P values of less than 0.05 significant. There was no influence of laryngoscopy and intubation on plasma catecholamine levels during the observation period. A continuous decrease in both levels of epinephrine and norepinephrine was significant. ADH levels showed no significant changes. Lidocaine had no influence on these endocrine parameters. MAP and HR increased after intubation in all groups studied. The increase in HR was less pronounced after lidocaine treatment. Coughing (4 patients) and ventricular dysrhythmia (2 patients) were observed only in patients without lidocaine treatment. In conclusion, no influence of different modes of treatment on the endocrine stress response during intubation became obvious. There was no indication that the cardiovascular symptoms during laryngoscopy and intubation are caused by systemic stress. An explanation may be a direct neural impulse via sympathetic efferents to the heart. On the other hand, topical application of lidocaine did prevent coughing and cardiac irritation, and the increase in HR was attenuated.(ABSTRACT TRUNCATED AT 250 WORDS)
Abteilung für Anaesthesiologie und operative Intensivmedizin, Klinikum der Justus-Liebig-Universität Giessen.
H A
HA
Adams
B
B
von Bormann
B
B
Bachmann
K
K
Ratthey
G
G
Hempelmann
D000287:Administration, Topical; D000770:Anesthesia, Endotracheal; D001794:Blood Pressure / Q000187:drug effects; D004702:Endocrine Glands / Q000503:physiopathology*; D004837:Epinephrine / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008012:Lidocaine / Q000008:administration & dosage; D009638:Norepinephrine / Q000097:blood; D013312:Stress, Physiological / Q000209:etiology*; D014667:Vasopressins / Q000097:blood
D014667:Vasopressins; D008012:Lidocaine; D009638:Norepinephrine; D004837:Epinephrine
Untersuchungen zur endokrinen Stress-Reaktion bei orotrachealer Intubation und Oberflächenanaesthesie mit Lidocain.