Destruction and repair of mammary gland parenchyma of cows infected with foot-and-mouth disease.
Bovine mammary gland secretory epithelial cells show signs of infection as early as three days after exposure of lactating host dairy cows to pigs infected with foot-and-mouth disease. Isolated foci of necrotic alveoli, as observed by scanning electron microscopy, increased in area and number with time. Infection of individual milk synthesizing cells progressed to involve the entire secretory epithelium. Alveolar luminal contents, in contrast to those in control preparations, consisted of heavy concentrations of cellular debris and connective tissue fragments; few leukocytes were observed. Involutionary changes occurred 10 days after cow exposure. Significant evidence of repair in necrotic areas was present at 15 days, but limited repair occurred earlier. Characteristics of replacement secretory epithelium made it possible to differentiate it from older mammary gland parenchyma.
J H
JH
Blackwell
S H
SH
Wool
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D004848:Epithelium / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D005536:Foot-and-Mouth Disease / Q000473:pathology*; D008321:Mammary Glands, Animal / Q000473:pathology / Q000648:ultrastructure*; D008855:Microscopy, Electron, Scanning; D009336:Necrosis