D-penicillamine-induced polymyositis in patients with rheumatoid arthritis.
Among 329 patients with rheumatoid arthritis treated with D-penicillamine (DP), we found 4 cases of polymyositis. This incidence was significantly higher than the expected coincidence of rheumatoid arthritis and polymyositis/dermatomyositis or than the presumed frequency of this complication among patients treated with DP. In the present report, we summarize and discuss the clinical findings in DP-induced polymyositis/dermatomyositis in our patients and others described in the literature.
Takahashi
K
K
Ogita
T
T
Okudaira
H
H
Yoshinoya
S
S
Yoshizawa
H
H
Miyamoto
T
T
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008875:Middle Aged; D009220:Myositis / Q000139:chemically induced*; D010396:Penicillamine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D010396:Penicillamine