Different temporal effects of serotonergic antagonists on passive avoidance retention.
The experiments examined the effects of acute administration of three different serotonergic receptor antagonists (ketanserin, pirenperone and mianserin) on one-trial passive avoidance retention in mice. Administration of each antagonist 30 min before training produced a dose-dependent impairment in retention. In contrast, administration of each of the antagonists immediately after training produced a dose-dependent improvement in retention. The time-dependent effects of pre- and post-train antagonist administration were assessed using pirenperone. In both cases, the effects on test performance were determined to be time-dependent. The results provide additional evidence suggestive of a differential role of the serotonergic nervous system in the processes underlying learning and memory.
Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI 48202.
H J
HJ
Altman
H J
HJ
Normile
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D008803:Mianserin / Q000494:pharmacology; D051379:Mice; D010880:Piperidines / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012153:Retention, Psychology / Q000187:drug effects* / Q000502:physiology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013997:Time Factors
D010880:Piperidines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D008803:Mianserin; D007650:Ketanserin; C034177:pirenperone