Studies on beta-lactam antibiotics. XI. Synthesis and structure-activity relationships of new 3-(2,2-dihalovinyl)cephalosporins.
The synthesis and in vitro antibacterial activity of 7 beta-[(Z)-2-(2-amino-4-thiazolyl)-2-carboxymethoxyiminoacetamido]- 3-(2,2-dihalovinyl)cephalosporins are described. 3-(2,2-Dihalovinyl)cephalosporins exhibited excellent antimicrobial activity against both Gram-positive and Gram-negative bacteria, especially showed higher activity against Staphylococcus aureus than the corresponding 3-vinylcephalosporin.
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Kawabata
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Masugi
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Takaya
D000818:Animals; D002511:Cephalosporins / Q000138:chemical synthesis*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D014316:Tritium
D002511:Cephalosporins; D014316:Tritium