Pharmacokinetics of cefotaxime and its desacetyl metabolite in plasma and in cerebrospinal fluid.
The aim of the study was to investigate the pharmacokinetic modelling of Cefotaxime (CTX) and its main metabolite Desacetyl Cefotaxime (DCTX) which has a less antibacterial activity than the CTX. After intravenous administration of 1g of CTX to 26 patients, the plasma concentrations determined by HPLC showed that the pharmacokinetics of CTX and transformation to DCTX can be described with an open five-compartment model. The implications of this are discussed from the clinical point of view.
Beyssac
E
E
Biopharmaceutics Department, Faculty of Pharmacy, Clermont-Ferrand, France.
Cardot
J M
JM
Colnet
G
G
Sirot
J
J
Aiache
J M
JM
D000293:Adolescent; D000328:Adult; D000368:Aged; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological
C029281:desacetylcefotaxime; D002439:Cefotaxime