Scleromyxoedema--successful treatment with plasma exchange and immunosuppression.
A 34-year-old woman with scleromyxoedema failed to respond to initial treatment with cyclophosphamide or psoralen-UVA photochemotherapy (PUVA). She developed neurological symptoms which resolved after five 4 l plasma exchanges performed on successive days, together with pulse methylprednisolone therapy. Subsequent treatment was with oral prednisolone and cyclophosphamide. She had had no further episodes of neurological dysfunction 8 months after plasma exchange, and the appearance of the skin had improved almost to normal. The complications and difficulty in management of scleromyxoedema are discussed.
Macfarlane
A W
AW
Department of Dermatology, Royal Liverpool Hospital, U.K.
Davenport
A
A
Verbov
J L
JL
Goldsmith
H J
HJ
D000328:Adult; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D009230:Myxedema / Q000473:pathology / Q000628:therapy*; D010951:Plasma Exchange; D012598:Sclerosis; D012867:Skin / Q000473:pathology*
D007166:Immunosuppressive Agents