Binding of Staphylococcus aureus by human serum spreading factor in an in vitro assay.
Human serum spreading factor, an animal cell adhesion-promoting glycoprotein, bound Staphylococcus aureus in an assay in which association of bacteria to protein-precoated microtiter wells was quantitated. Interaction of human serum spreading factor with S. aureus suggests that this protein may play a role in host defenses and in the invasiveness and pathogenicity of microbial infections.
J I
JI
Fuquay
D T
DT
Loo
D W
DW
Barnes
D000911:Antibodies, Monoclonal / Q000276:immunology; D000937:Antigen-Antibody Reactions; D005109:Extracellular Matrix / Q000382:microbiology; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007797:Laminin / Q000378:metabolism; D011133:Polysaccharide-Lyases / Q000276:immunology / Q000378:metabolism*; D012995:Solubility; D013211:Staphylococcus aureus / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D005353:Fibronectins; D007797:Laminin; D011133:Polysaccharide-Lyases; C100002:hyaluronate lyase