Free perforation due to cancer in Crohn's disease.
Free perforation of cancer in Crohn's disease is exceedingly rare. Three cases were found among 1010 patients admitted to Mount Sinai Hospital between 1960 and 1980. Free perforation of cancer occurs late in the course of Crohn's disease between the second and third decades of disease, whereas spontaneous free perforation usually occurs within the first 5 years. Cancer-related perforation is associated with weight loss, mass and fistula, and carries a poor prognosis.
Greenstein
A J
AJ
Department of Surgery, Mount Sinai School of Medicine of the City University of New York, New York.
Gennuso
R
R
Sachar
D B
DB
Aufses
A H
AH
D000230:Adenocarcinoma / Q000150:complications; D000236:Adenoma / Q000150:complications; D000328:Adult; D003110:Colonic Neoplasms / Q000150:complications*; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology*; D007580:Jejunal Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies