Rheumatoid arthritis: explanatory power of specific radiographic findings for patient clinical status.
Radiographs of the hands and wrists of 201 patients with rheumatoid arthritis (RA) were scored for erosion, joint space narrowing, and malalignment. The explanatory power of these findings for measures of clinical status was studied with stepwise multiple linear regression analyses. Radiographic scores explained 59.2% of variation in physical joint count deformity scores, 58.5% of variation in limited motion scores, 22.5% of variation in grip strength scores, 20.5% of variation in button test scores, and 13.5% of variation for the American Rheumatism Association (ARA) Functional Class. Malalignment scores best explained variation in physical deformity, limited motion, and button test scores; joint-space-narrowing scores best explained variation in grip strength; erosion scores best explained variation in ARA Functional Class. When age, duration of disease, erythrocyte sedimentation rate, and rheumatoid factor titer were included in the regression analyses, results were similar to those without these variables. Therefore quantitative scores of specific radiographic findings are in themselves explanatory for measures of clinical status.
Department of Radiology, Vanderbilt University Medical Center, Nashville, TN 37232.
J J
JJ
Kaye
L F
LF
Callahan
E P
EP
Nance
R H
RH
Brooks
T
T
Pincus
D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002908:Chronic Disease; D005260:Female; D005384:Finger Joint / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D004204:Joint Dislocations / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009068:Movement; D011379:Prognosis; D011859:Radiography; D012044:Regression Analysis; D014955:Wrist Joint / Q000000981:diagnostic imaging / Q000503:physiopathology