Study of the teratogenic potential of gum arabic.
Gum arabic in the diet at 0, 1, 2, 4, 7.5 or 15% was available ad lib. to male and female Osborne-Mendel rats during premating and mating and throughout gestation. During gestation, the treated females consumed from 683 mg gum/kg body weight/day in the 1% group to 10,647 mg gum/kg/day in the 15% group. The animals were killed on gestation day 20. There were no dose-related changes in maternal findings, number of foetuses, foetal viability or external, visceral or skeletal variations. No terata were seen.
Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC 20204.
T F
TF
Collins
J J
JJ
Welsh
T N
TN
Black
S L
SL
Graham
L H
LH
Brown
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000002:abnormalities; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D006170:Gum Arabic / Q000633:toxicity*; D008297:Male; D011134:Polysaccharides / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats
D011134:Polysaccharides; D006170:Gum Arabic