Developmental profile of serum androgens and estrous cyclicity of male and female rats exposed, perinatally, to maternally administered phenytoin.
Pregnant rats were treated, daily, with either 10, 50 or 100 mg/kg of phenytoin-Na from day 17 of gestation through postpartum day 7. The male and female offspring exposed to the 2 higher doses of phenytoin had smaller body weights at birth than the diluent-treated rats, and this subnormal body weight gain persisted throughout the life of the affected animals. In contrast, the anticonvulsant produced no adverse effects on the developmental profile of serum androstenedione, testosterone and dihydrotestosterone or estrous cyclicity in the exposed male and female offspring, respectively. In spite of the normal concentrations of serum androgens, the seminal vesicles of the adult rats exposed to the 50 and 100 mg/kg doses of phenytoin were significantly smaller than the diluent-treated males.
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6048.
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BH
Shapiro
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Babalola
D000728:Androgens / Q000097:blood*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D008297:Male; D010672:Phenytoin / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D012669:Seminal Vesicles / Q000187:drug effects
D000728:Androgens; D010672:Phenytoin