Emetic activity of the trichothecene 15-acetyldeoxynivalenol in swine.
The emetic activity of 15-acetyldeoxynivalenol (15-ADON), a deoxynivalenol (DON) precursor, was evaluated in swine over a dose range of 25-200 micrograms/kg body weight and found to be very similar to that of DON. The minimum effective oral doses for 15-ADON and DON were 75 and 50 micrograms/kg, respectively, with 3/15 of the 15-ADON- and 4/15 of the DON-treated pigs exhibiting emesis, over the total dose range. The minimum effective ip doses for 15-ADON and DON were also 75 and 50 micrograms/kg, respectively, with 9/15 pigs in each group exhibiting emesis, over the total dose range. For pigs receiving 15-ADON and DON ip, increased dosage was associated with decreased average time to vomition, increased duration of emesis and increased average number of vomitions.
Pestka
J J
JJ
Department of Food Science and Human Nutrition, Michigan State University, East Lansing 48824-1224.
Lin
W S
WS
Miller
E R
ER
D000818:Animals; D004305:Dose-Response Relationship, Drug; D012044:Regression Analysis; D012717:Sesquiterpenes / Q000633:toxicity*; D013552:Swine; D014255:Trichothecenes / Q000378:metabolism / Q000633:toxicity*; D014839:Vomiting / Q000139:chemically induced*
D012717:Sesquiterpenes; D014255:Trichothecenes; C046760:15-acetyldeoxynivalenol; C007262:deoxynivalenol