Delay of nomifensine-induced seizures by fusaric acid, alpha-methyltyrosine and haloperidol.
An In Vivo model is presented to determine the effects of alpha methyl-para-tyrosine methyl ester (MPT), fusaric acid (FA), and haloperidol on nomifensine-induced seizures. All three drugs were active with haloperidol having the greatest effect on delay of onset to convulsion. The results suggest that both dopamine and norepinephrine are involved in nomifensive-induced convulsions and that administering agents known to lower both dopamine and/or norepinepherine in the rat brain delays onset but that haloperidol, which specifically blocks post-synaptic dopamine receptors, had the greatest activity.
M R
MR
Huff
G G
GG
Meadows
W E
WE
Johnson
D000818:Animals; D001921:Brain / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology*; D005669:Fusaric Acid / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology*; D009627:Nomifensine / Q000037:antagonists & inhibitors*; D009638:Norepinephrine / Q000502:physiology*; D010848:Picolinic Acids / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology
D008781:Methyltyrosines; D010848:Picolinic Acids; D009627:Nomifensine; D006220:Haloperidol; D005669:Fusaric Acid; D004298:Dopamine; D009638:Norepinephrine