[Recovery of acetylcholinesterase activity in the axolotl embryo following inhibition with the organophosphorus inhibitor Gd-7].
The restoration of acetylcholinesterase (AChE) activity in axolotl Ambystoma mexicanum embryo after treatment at 38-42 stages with irreversibly AChE-inhibiting Gd-7 phosphororganic inhibitor in concentrations, significantly decreasing AChE activity level, but not interfering with ontogenesis has been studied. The rate of AChE activity restoration in Gd-7 treated axolotl embryo depends on the level of the enzyme restraint and the stage of the embryo development. The value of maximal restoration of AChE activity differs; it is less in embryos, treated with Gd-7 at later stages of development. The ability of the embryos to swim restores parallel to the increase in AChE activity. The data obtained suggest that axolotl embryo possess compensatory mechanism for increasing AChE biosynthesis after decrease in its activity caused by Gd-7. Acetylcholine, accumulating in the organism at partial inactivation of AChE by phosphororganic inhibitor may participate in this mechanism.
M N
MN
Semenova
T M
TM
Turpaev
D000110:Acetylcholinesterase / Q000096:biosynthesis*; D000557:Ambystoma / Q000196:embryology* / Q000378:metabolism; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D002801:Cholinesterase Reactivators; D004625:Embryo, Nonmammalian / Q000201:enzymology; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D009946:Organothiophosphorus Compounds; C014884:GD 7; D000110:Acetylcholinesterase
Vosstanovlenie aktivnosti atsetilkholinésterazy zarodysheĭ aksolotlia posle ugneteniia fosfororganicheskim ingibitorom Gd-7.