Pancreatic carcinoma in childhood.
A case of pancreatic carcinoma in a 14-year-old Japanese boy is reported. He complained of general fatigue, anorexia, abdominal distension, and abdominal mass. At autopsy, a whitish tumor was found from the head to the body of the pancreas. Metastasis was found in the liver, lungs, gall bladder, and various lymph nodes such as stomach, hilus, and periaorta. The tumor was histologically determined to be moderately differentiated adenocarcinoma (cribriform type) of duct cell origin. However, the tumors showed PAS-positive diastase-resistant mucus in the cytoplasm. Histocytology showed the positivity for alpha 1-antitrypsin, secretory component (sc), and CEA, but no S-amylase was detected in the cytoplasm. Electron microscopy revealed zymogen-like granules in the cytoplasm suggesting acinar differentiation.
S
S
Imai
Y
Y
Kiyozuka
Y
Y
Tsubura
H
H
Yamamoto
T
T
Morohoshi
M
M
Fujimoto
T
T
Tsujii
D000293:Adolescent; D001650:Bile Duct Neoplasms / Q000556:secondary; D006801:Humans; D007564:Japan; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008854:Microscopy, Electron; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D010503:Periodic Acid-Schiff Reaction