A new method for examining the interdependence among toxic endpoints.
Many toxicological problems involve interdependence among several endpoints, the values of which vary randomly over time and in relation to each other. For two endpoints, correlation analysis can be used to determine interdependence. Since correlation between more than two endpoints is not defined, higher order interdependence is determined using multivariate methods. This paper presents the first description of a correlation measure that can be used to test interdependence among more than two endpoints. The observations for each endpoint must be expressible as binary (0 or 1) values. This measure is illustrated using teratogenicity, mutagenicity, and carcinogenicity data for 104 compounds. All possible bivariate correlations were determined to be significant. The three-wise correlation was also significant.
Schaeffer
D J
DJ
Department of Veterinary Biosciences, University of Illinois, Urbana 61801.
D002273:Carcinogens; D004347:Drug Interactions; D008956:Models, Chemical; D009152:Mutagenicity Tests; D013723:Teratogens
D002273:Carcinogens; D013723:Teratogens