Immunomodulating activities associated with the cytosol fraction of a 3-methylcholanthrene-induced rat fibrosarcoma--II. Association with polyamine complexes.
This paper characterizes the molecular nature of the factors present in cytosol from F-344 rat McFiFi2(s) fibrosarcoma cells (FiCF) which mediate inhibition of PHA-induced lymphoproliferative responses. These are polyamines (spermine/spermidine) conjugated to different protein carriers. Interaction of these complexes with polyamine oxidase (PAO) present in fetal calf or rat serum is responsible of the suppression observed.
Pommier
G J
GJ
Garrouste
F
F
Remacle-Bonnet
M M
MM
Depieds
R C
RC
D000818:Animals; D002417:Cattle; D003600:Cytosol / Q000276:immunology; D005354:Fibrosarcoma / Q000139:chemically induced / Q000276:immunology* / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology; D007108:Immune Tolerance; D007700:Kinetics; D008213:Lymphocyte Activation; D008748:Methylcholanthrene; D009363:Neoplasm Proteins / Q000276:immunology*; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000037:antagonists & inhibitors / Q000276:immunology*; D011073:Polyamines / Q000276:immunology*; D051381:Rats; D000097667:Polyamine Oxidase
D006146:Guanidines; D008748:Methylcholanthrene; D009363:Neoplasm Proteins; D000587:Oxidoreductases Acting on CH-NH Group Donors; D011073:Polyamines; D000097667:Polyamine Oxidase; C004479:pimagedine