Primary infertility in women exposed to diethylstilboestrol in utero.
In a selected group of 40 women who had been exposed to diethylstilboestrol in utero, 18 conceived without difficulty and 22 had primary infertility. Among those with primary infertility there was a significantly higher rate of anatomical structural defects and a greater tendency for menstrual disorders than in those without infertility. Thirteen (59%) of the women with primary infertility conceived, most after treatment with ovulation stimulating drugs. Spontaneous abortion and tubal pregnancy were frequent (47% and 10% respectively) and similar in both fertility groups. Of 13 infertile women examined, 4 (31%) had mild hyperprolactinemia--a hithero unreported finding for such women.
Menczer
J
J
Dulitzky
M
M
Ben-Baruch
G
G
Modan
M
M
D000022:Abortion, Spontaneous / Q000139:chemically induced; D000328:Adult; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D005836:Genitalia, Female / Q000002:abnormalities; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced*; D008599:Menstruation Disturbances / Q000139:chemically induced; D011247:Pregnancy; D011248:Pregnancy Complications; D011274:Pregnancy, Tubal / Q000139:chemically induced; D011297:Prenatal Exposure Delayed Effects; D011388:Prolactin / Q000097:blood
D004054:Diethylstilbestrol; D011388:Prolactin