Probenecid induced immune hemolytic anemia.
We report a patient who, while receiving probenecid and colchicine for acute gouty arthritis, developed severe hemolytic anemia in association with a generalized rash. The hemolysis was immune mediated as shown by a positive direct Coombs' test. In vitro hematologic studies showed that a probenecid dependent antibody was present.
T S
TS
Kickler
S
S
Buck
P
P
Ness
R S
RS
Shirey
P W
PW
Sholar
D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced* / Q000276:immunology; D001168:Arthritis / Q000188:drug therapy; D003078:Colchicine / Q000627:therapeutic use; D003298:Coombs Test; D004359:Drug Therapy, Combination; D006073:Gout / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011339:Probenecid / Q000009:adverse effects* / Q000627:therapeutic use; D012699:Serology
D011339:Probenecid; D003078:Colchicine