Genetic distance analysis using DNA polymorphisms in the alpha-globin gene cluster.
Published frequencies for alleles at the alpha- and zeta-globin gene loci within the alpha-globin gene cluster were used to calculate genetic distances between populations of South East Asia and the Pacific region. When analyses using the alpha-globin alleles, populations are grouped according to the endemicity of malaria while the groupings derived from the embryonic zeta-globin allele frequencies appear to be far less influenced by the incidence of malaria and probably reflect ancestral or chance relationships due to founder effects, migration and small population sizes.
Department of Human Genetics, John Curtin School of Medical Research, Canberra.
K M
KM
Summers
P
P
Yenchitsomanus
R M
RM
Chapple
D000483:Alleles; D001315:Australia; D004247:DNA / Q000235:genetics*; D005828:Genetics, Population; D005914:Globins / Q000235:genetics*; D006801:Humans; D007214:Indonesia; D005810:Multigene Family; D010139:Pacific Islands; D010219:Papua New Guinea; D011110:Polymorphism, Genetic
D005914:Globins; D004247:DNA