[Unstable stenocardia: functional activity and free cytoplasmic calcium of thrombocytes and vaso- and thrombocytoactive prostanoids].
Platelet function was studied in patients with diverse clinical patterns of unstable angina. In vasospastic angina, anginal attacks coincide with the highest increment in Ca2+ of platelets, and their high sensitivity to aggregation inductors, which declines as the condition stabilizes. Unstable angina without the vasospastic component is associated with reduced platelet sensitivity to aggregation inductors, particularly so in patients showing signs of intracoronary thrombosis. Spontaneous anginal attacks are accompanied with a rise of thromboxane B2 and a drop in the stable prostacyclin metabolite level.
Panchenko
E P
EP
Shalaev
S V
SV
Gratsianskiĭ
N A
NA
Giorgadze
M L
ML
Popov
Iu M
IuM
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000328:Adult; D000787:Angina Pectoris / Q000097:blood*; D000789:Angina, Unstable / Q000097:blood*; D001792:Blood Platelets / Q000502:physiology* / Q000648:ultrastructure; D002118:Calcium / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D013929:Thromboxane B2 / Q000097:blood*
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D002118:Calcium
Nestabil'naia stenokardiia: funktsional'naia aktivnost', svobodnyĭ tsitoplazmaticheskiĭ kal'tsiĭ trombotsitov, vazo- i trombotsitoaktivnye prostanoidy.