Stearic acid and carcinogenesis.
Decreased membrane rigidity is one of the characteristics of malignant cells, resulting in part from the desaturation of stearic acid into oleic acid. In this study we investigated the influence of stearic acid on tumour cell inhibition in vitro and tumour development in vivo. Stearic acid inhibited the colony-forming ability of 4 out of 5 rat and two human tumour continuous cell lines in vitro. In contrast, the colony-forming ability of rat fibroblasts was not inhibited and that of human foetal lung fibroblasts was inhibited at a higher dose than that required to inhibit human tumour cell lines. Using a model of rat mammary carcinoma induced by nitroso-methyl urea (NMU) the subcutaneous injection of stearic acid at weekly intervals prevented tumour development in 5 to 10 rats. Using iodostearic acid twice weekly, 11 of 19 rats were alive and tumour free at week 22 whilst all of 14 animals injected with NMU alone had died of tumour by the 16th week. The ratio of stearic to oleic acids in erythrocyte membranes was significantly reduced in the tumour-bearing rats, but was normal in tumour-free animals treated with stearic or iodostearic acid. These preliminary data indicate that stearic acid inhibits tumour development in rats.
University Department of Surgery, Bristol Royal Infirmary, UK.
N A
NA
Habib
C B
CB
Wood
K
K
Apostolov
W
W
Barker
M J
MJ
Hershman
M
M
Aslam
D
D
Heinemann
B
B
Fermor
R C
RC
Williamson
W E
WE
Jenkins
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000517:prevention & control; D008325:Mammary Neoplasms, Experimental / Q000517:prevention & control; D019301:Oleic Acid; D009829:Oleic Acids / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013229:Stearic Acids / Q000097:blood / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014410:Tumor Stem Cell Assay
D000970:Antineoplastic Agents; D009829:Oleic Acids; D013229:Stearic Acids; D019301:Oleic Acid; C031183:stearic acid