[Mechanism of action of naphthoquinones and hydroxycoumarins on the mechano-active properties of isolated coronary arteries].
The action of natural naphthoquinones and their antagonists oxicoumarins on mechanoactive properties of isolated coronary arteries was studied in experiments on male albino rats. Vitamin K deficiency (primary, secondary) was found to be accompanied with disturbances of mechanoactive properties of the heart vessels Naphthoquinones (vitamins K1 and K3) exerted a spasmolytic action on coronary vessels of intact animals and animals with vitamin K deficiency as well. These effects are supposed to be probably related to the redistribution of cations Ca2+ and K+ in membranes.
Lider
V A
VA
Shishkin
S B
SB
Feofilaktova
S N
SN
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001696:Biomechanical Phenomena; D003331:Coronary Vessels / Q000187:drug effects* / Q000503:physiopathology; D003374:Coumarins / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000503:physiopathology; D009285:Naphthoquinones / Q000494:pharmacology*; D010276:Parasympatholytics; D051381:Rats; D014813:Vitamin K Deficiency / Q000503:physiopathology
D003374:Coumarins; D009285:Naphthoquinones; D010276:Parasympatholytics
K mekhanizmu deĭstviia naftokhinonov i oksikumarinov na mekhanoaktivnye svoĭstva izolirovannykh koronarnykh arteriĭ.