Controlled release using a new bioerodible polyphosphazene matrix system.
Polyphosphazenes possess polymer backbones consisting of nitrogen and phosphorous formally separated by alternating single and double bonds. Their potential for biomedical applications stems from the fact that polymers with a wide array of properties can be synthesized using the same starting compound, poly(dichlorophosphazene), through changes in side chain substituents, and that many of these compounds synthesized have been found to biodegrade to harmless products. In this article, studies of a novel monolithic bioerodible polyphosphazene matrix system for controlled drug delivery are presented. Poly(imidazole methylphenoxy)phosphazene is synthesized and shown to be bioerodible. The versatility of drug delivery devices fabricated using this polymer is shown through studies of release of macro-molecules and low molecular weight drugs. Initial histological evaluations of this particular polyphosphazene are also presented.
Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge.
C T
CT
Laurencin
H J
HJ
Koh
T X
TX
Neenan
H R
HR
Allcock
R
R
Langer
D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D003692:Delayed-Action Preparations; D007093:Imidazoles / Q000008:administration & dosage / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000378:metabolism* / Q000633:toxicity; D011108:Polymers / Q000138:chemical synthesis / Q000378:metabolism* / Q000633:toxicity; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012710:Serum Albumin, Bovine / Q000378:metabolism
D000814:Aniline Compounds; D003692:Delayed-Action Preparations; D007093:Imidazoles; D009943:Organophosphorus Compounds; D011108:Polymers; C019498:4-nitroaniline; D012710:Serum Albumin, Bovine; D011374:Progesterone