Infection with influenza A H1N1. 2. The effect of past experience on natural challenge.
Following its reintroduction in 1978 influenza A H1N1 spread widely in the child population. By the autumn of 1979, 75% of 11-year olds entering a boys' boarding school had detectable antibody. The protective effect of previous experience could be assessed during two outbreaks in the school. In the first outbreak in 1979, 90% of those known to have been infected in the previous year were protected against reinfection. In 1983 after strains of the H1N1 subtype had undergone antigenic drift a large outbreak occurred. It was estimated that past infection conferred protection against clinical influenza in 55%. Where past infection resulted in the presence of antibody which reacted with the outbreak strain the attack rate was further reduced. A large number of sub-clinical infections was detected in all groups.
Davies
J R
JR
Grilli
E A
EA
Smith
A J
AJ
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D004196:Disease Outbreaks / Q000276:immunology / Q000382:microbiology; D004739:England; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D009980:Influenza A virus / Q000145:classification / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D012703:Serotyping
D000914:Antibodies, Viral