Novel activity of melatonin. Its chemotactic effect on retinal pigment epithelial cells.
Melatonin (100 nM-100 microM) showed a chemotactic action on cultured chick retinal pigment epithelial cells. This effect was equivalent to that of N-formyl methionyl-leucyl-phenylalanine. Other methoxyindole derivatives had no or less chemotactic effects than melatonin.
Department of Ophthalmology, Kyoto University Faculty of Medicine, Japan.
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Shirakawa
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Ogino
D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D002630:Chemotactic Factors / Q000494:pharmacology*; D002645:Chickens; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D008550:Melatonin / Q000494:pharmacology*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009994:Osmolar Concentration; D010857:Pigment Epithelium of Eye / Q000166:cytology / Q000187:drug effects*
D002630:Chemotactic Factors; D009240:N-Formylmethionine Leucyl-Phenylalanine; D008550:Melatonin