Evidence for H-2-linked control of retrovirus production in Friend virus-induced tumor cell lines.
In Friend leukemia virus-induced tumor cell lines derived from mice congenic with respect to the H-2 complex, most cell lines expressing the H-2k haplotype continuously produced infectious exogenous virus in culture, whereas most cell lines expressing the H-2b or H-2d haplotype stopped producing virus during in vitro passage. This apparent H-2-linked control of virus production did not appear to be the result of alteration of the provirus or resistance to superinfection. The implications of this finding with respect to virus-induced leukemogenesis are discussed.
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D000818:Animals; D002460:Cell Line; D005622:Friend murine leukemia virus / Q000502:physiology*; D006183:H-2 Antigens / Q000032:analysis / Q000235:genetics*; D007065:Idoxuridine / Q000494:pharmacology; D007942:Leukemia, Experimental / Q000209:etiology / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D012190:Retroviridae / Q000502:physiology*; D014764:Viral Proteins / Q000032:analysis
D006183:H-2 Antigens; D014764:Viral Proteins; D007065:Idoxuridine