[Ratio of the frequency of chromosome aberrations and sister chromatid exchanges to the dose of the mutagenic exposure to cyclophosphamide in vivo and in vitro].
Cyclophosphamide (CP) and its metabolites were used to compare the rate of chromosomal aberrations (CA) and sister chromatid exchange (SCE) in the rabbit lymphocytes in vivo and in vitro. The dose-dependent increase of cytogenetic effects rate appeared to be of linear and exponential dependence for SCE and CA, respectively, both in vivo and in vitro. The regression equation coefficients coincided in in vivo and in vitro experiments.
S V
SV
Stukalov
S M
SM
Kuzin
V V
VV
Viktorov
D000818:Animals; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008214:Lymphocytes / Q000187:drug effects; D008677:Metaphase / Q000187:drug effects; D009153:Mutagens; D011817:Rabbits; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D009153:Mutagens; D003520:Cyclophosphamide
Zavisimost' chastot khromosomnykh aberratsiĭ i sestrinskikh khromatidnykh obmenov ot dozy mutagennogo vozdeĭstviia tsiklofosfamida in vivo i vitro.