[Studies on the bioequivalence of canrenone using pharmacokinetic data and clinical effects].
Canrenon, an active metabolite of spironolactone, and the combination of Canrenon with hydrochlorothiazide (HCT) were examined on patients with essential hypertension, cardial oedemas and oedemas of different origin, and than compared to a product available on the market. A correlation of the clinical effect (e.g. systolic blood pressure) with the morning steady state-data (blood values of Canrenon and HCT) has been achieved. The new preparations showed a good resorption in the gastro-intestinal tract. For an equivalent clinical effect, less Canrenon substance has been needed. A therapeutically satisfactory result has been reached with the administered dosage of both Canrenon and the comparison group. In the combination the higher dosage level should be chosen.
Wallnöfer
H
H
Medizinische Abteilung, Krankenhaus Vöcklabruck.
Gopold
B
B
Schneider
J
J
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002192:Canrenone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D000451:Mineralocorticoid Receptor Antagonists / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011245:Pregnadienes / Q000493:pharmacokinetics*; D013810:Therapeutic Equivalency
D004338:Drug Combinations; D000451:Mineralocorticoid Receptor Antagonists; D011245:Pregnadienes; D006852:Hydrochlorothiazide; D002192:Canrenone
Untersuchungen zur Bioäquivalenz von Canrenon mittels pharmakokinetischer Daten und klinischem Effekt.