Phase II trial of mitomycin plus cisplatin in the treatment of advanced colorectal adenocarcinoma.
Cisplatinum may be synergistic if used in combination with other agents. This study was undertaken to investigate whether a mitomycin plus cisplatin in combination could show any promising data in colorectal cancer. The regimen did not show sufficient activity to encourage further trials.
Division of Radiotherapy and Oncology, U.S.S.L. 28, Legnago, Verona.
R
R
Demicheli
A
A
Jirillo
G
G
Bonciarelli
F
F
Lonardi
M
M
Balli
D000230:Adenocarcinoma / Q000188:drug therapy*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008937:Mitomycins / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000188:drug therapy*
D008937:Mitomycins; D002945:Cisplatin