The management of severe brittle diabetes with "Infusaid" implantable pumps.
Two severely brittle diabetic patients were treated with "Infusaid" implantable insulin infusion pumps. Both were young females with recurrent ketoacidosis, prolonged or repeated hospital admissions, and subcutaneous insulin resistance. They also had psychological problems, and had seriously interfered with their treatment to induce glycaemic instability. Delivery of insulin from the pumps was intravenous (i.v.) in one patient, and intraperitoneal (i.p.) in the other. Following implantation, there was a marked improvement in glycosylated haemoglobin level (HbA1), fasting blood glucose (BG), daily insulin dose and hospitalizations. The beneficial effect has continued to date (9 months, and 12 months follow-up) with no major problems.
G V
GV
Gill
D J
DJ
Husband
P D
PD
Wright
G
G
Sharpe
R
R
Taylor
S
S
Walford
S M
SM
Marshall
K G
KG
Alberti
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007332:Insulin Infusion Systems; D007333:Insulin Resistance
D001786:Blood Glucose; D006442:Glycated Hemoglobin