Surgery in combined pulmonary and neural cryptococcosis.
A 39-year-old previously healthy patient with combined pulmonary and neural cryptococcosis was successfully managed by pulmonary resection and antifungal chemotherapy. The pulmonary mass was removed under cover of miconazole and 5-fluorocytosine even though the patient had concomitant active meningitis. He recovered dramatically after the surgical procedure and remained well 2 years later. We suggest that, as in our patient, early removal of a pulmonary cryptococcal mass under antifungal cover may in other similar patients obviate the need for protracted antifungal therapy and lead to an excellent response of the neural cryptococcosis.
Sa'adah
M A
MA
University Department of Neurology, IbnSina Hospital, Kuwait.
Shakir
R A
RA
Jadaa
S I
SI
Bezjak
V
V
Araj
G F
GF
D000328:Adult; D003131:Combined Modality Therapy; D003453:Cryptococcosis / Q000188:drug therapy / Q000601:surgery*; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications / Q000601:surgery*; D008297:Male; D008581:Meningitis / Q000150:complications / Q000188:drug therapy*; D008825:Miconazole / Q000627:therapeutic use
D008825:Miconazole; D005437:Flucytosine