Diversity of the effect of phosphatidylcholine and sphingomyelin on adenylate deaminase from pig brain.
Liposomes made of sphingomyelin were found to inhibit both ATP-activated and non-activated AMP deaminase from pig brain, in contrast to liposomes made of egg yolk phosphatidylcholine which exhibited an activating effect on the ATP-activated enzyme, being without effect on AMP deaminase in the absence of ATP. Dioleoylphosphatidylcholine exerted a similar effect as egg yolk phosphatidylcholine but dipalmitoylphosphatidylcholine was without effect.
Woźniak
M
M
Department of Biochemistry, Academic Medical School, Gdańsk, Poland.
Purzycka-Preis
J
J
Kossowska
E
E
Zydowo
M M
MM
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000494:pharmacology; D000659:AMP Deaminase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D007700:Kinetics; D008081:Liposomes; D009709:Nucleotide Deaminases / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000494:pharmacology*; D013109:Sphingomyelins / Q000494:pharmacology*; D013552:Swine
D008081:Liposomes; D010713:Phosphatidylcholines; D013109:Sphingomyelins; D015060:1,2-Dipalmitoylphosphatidylcholine; D000255:Adenosine Triphosphate; D009709:Nucleotide Deaminases; D000659:AMP Deaminase; C017251:1,2-oleoylphosphatidylcholine