Effects of irradiation on human platelets stored at 20 degrees C.
The morphologic and functional properties of platelets after irradiation with 2500 rads and storage, in first-generation containers, for 48 h in a liquid phase at 20 degrees C with continuous horizontal agitation have been analyzed and compared with a control group of the same platelets which were not irradiated. The preservation technique induced changes in the morphology and aggregation stimulated by ADP and collagen. However, no significant differences were found between the irradiated and non-irradiated groups. Irradiation is not a conditioning factor to add to the hazards of preserving platelets in a liquid phase.
Postgraduate School of Haematology, Farreras Valenti, Hospital Clínico, University of Barcelona, Spain.
P
P
Marin
C
C
Le Forestier
F
F
Beaujean
N
N
Duedari
A
A
Valls
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000528:radiation effects*; D001793:Blood Preservation / Q000379:methods*; D003080:Cold Temperature; D003094:Collagen / Q000494:pharmacology; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects
D000244:Adenosine Diphosphate; D003094:Collagen