Structure and chemotherapeutical activity of a polyisoprenylated benzophenone from the stem bark of Garcinia huillensis.
The stem bark of Garcinia huillensis grown in Zaïre and used in central-African traditional medicine has been subjected to a bioassay-guided fractionation. The chemotherapeutically active petroleum ether extract afforded fatty acids, aliphatic alcohols, triterpenes and a polyisoprenylated benzophenone, which was identified as garcinol, also named camboginol. This compound has been shown to exhibit chemotherapeutical activity gram-positive and gram-negative cocci, mycobacteria and fungi. On the other hand garcinol has been found to be inactive against gram-negative enteric bacilli, yeasts and viruses.
Ecole de Pharmacie, Université de Kinshasa, Zaïre.
P
P
Bakana
M
M
Claeys
J
J
Totté
L A
LA
Pieters
L
L
Van Hoof
Tamba-Vemba
D A
DA
Van den Berghe
A J
AJ
Vlietinck
D000998:Antiviral Agents; D001419:Bacteria / Q000187:drug effects; D003470:Culture Media; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000032:analysis* / Q000494:pharmacology
D000998:Antiviral Agents; D003470:Culture Media; D010936:Plant Extracts; D013729:Terpenes; C054597:garcinol