The absorption and degradation of isoflurane and I-653 by dry soda lime at various temperatures.
The capacity of dry soda lime to absorb and degrade isoflurane and a new inhaled anesthetic, I-653, was measured at normal, decreased, and increased temperatures. Both agents were absorbed at all temperatures tested (0, 20, 40, and 60 degrees C). Absorption of isoflurane into a molecular sieve-like portion of dry soda lime was 30% (40 degrees C) to 115% (0 degrees C) greater than that of I-653. Similarly, the quasipartition coefficient for dry soda lime was 18% (0 degrees C) to 212% (20 degrees C) greater with isoflurane than with I-653. Degradation rates for the two anesthetics were comparable, although slightly higher for I-653 than for isoflurane. Fractional degradation rates for both agents increased with increasing temperature and decreased as the concentration of agent increased.
Department of Anesthesia, University of California, San Francisco 94143-0542.
E I
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Eger
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D000042:Absorption; D000777:Anesthetics; D017610:Calcium Compounds; D000077335:Desflurane; D003890:Desiccation; D004355:Drug Stability; D007530:Isoflurane / Q000031:analogs & derivatives*; D010087:Oxides; D012972:Sodium Hydroxide
D000777:Anesthetics; D017610:Calcium Compounds; D010087:Oxides; C004569:soda lime; D012972:Sodium Hydroxide; D000077335:Desflurane; D007530:Isoflurane