Toxicity of Pluronic F-68.
The toxicity of Pluronic F-68, a non-ionic polyol, was studied in the rat when administered intravenously for one month in daily doses of 0, 10, 20, 50, 100, 200, 500 and 1000 mg/kg. Pluronic F-68 induced pulmonary foam cells at the dose levels of 500 and 1000 mg/kg and slight focal degenerative changes in the proximal tubules of the kidneys at the dose levels of 100, 200, 500 and 1000 mg/kg. The cytoplasm of the pulmonary foam cells contained lipid droplets, phospholipids being the most essential constituent. The results indicate that Pluronic F-68 is able to induce phospholipidosis in the rat. Only drugs have so far been reported to cause this condition in the rat.
Magnusson
G
G
Olsson
T
T
Nyberg
J A
JA
D000818:Animals; D005260:Female; D005487:Foam Cells / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008064:Lipidoses / Q000139:chemically induced / Q000473:pathology; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010743:Phospholipids / Q000378:metabolism; D011060:Poloxalene / Q000633:toxicity*; D011092:Polyethylene Glycols / Q000633:toxicity*; D051381:Rats
D010743:Phospholipids; D011092:Polyethylene Glycols; D011060:Poloxalene