Substituted 1-benzylimidazole-2-thiols as potent and orally active inhibitors of dopamine beta-hydroxylase.
L I
LI
Kruse
C
C
Kaiser
W E
WE
DeWolf
J S
JS
Frazee
R W
RW
Erickson
M
M
Ezekiel
E H
EH
Ohlstein
R R
RR
Ruffolo
B A
BA
Berkowitz
D000284:Administration, Oral; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002417:Cattle; D004298:Dopamine / Q000032:analysis; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*; D007093:Imidazoles / Q000494:pharmacology*; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000494:pharmacology*
D007093:Imidazoles; D013438:Sulfhydryl Compounds; D004299:Dopamine beta-Hydroxylase; D004298:Dopamine; D009638:Norepinephrine