The effect of human leptospirosis on the composition and concentration of serum lipids and lipoproteins.
1. Plasma lipids and lipoproteins were studied in 9 male patients during the immune phase of leptospirosis and 4 months later after recovery. 2. Electrophoretic patterns of plasma lipoproteins were characterized by the absence of alpha- and pre-beta lipoprotein bands and the presence of a single broad beta band. The high-density lipoprotein (HDL) fraction ran in the pre-beta position and triglyceride (TG) content was high. Low-density lipoproteins (LDL) moved into three different bands and were rich in TG. Very low-density lipoproteins (VLDLs) migrated normally and their triglyceride content was low. All lipoprotein fractions had low levels of cholesteryl esters. 3. In infected patients, the fractional lecithin:cholesterol acyltransferase (LCAT) rate (%/h) was low, while the molar LCAT rate (mumol 1(-1)h-1 remained unchanged. Both VLDL and LDL cholesterol levels increased while HDL cholesterol decreased. 4. These findings demonstrated that abnormalities in lipoprotein composition are associated with leptospiral liver injury.
Cisternas
J R
JR
Departamento de Fisiologia, Faculdade de Ciências Médicas, Santa Casa de São Paulo, Brasil.
Milstein-Kuschnaroff
T
T
D000328:Adult; D004588:Electrophoresis, Cellulose Acetate; D004951:Esterification; D006801:Humans; D007922:Leptospirosis / Q000097:blood* / Q000503:physiopathology; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000503:physiopathology*; D008297:Male; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*
D008055:Lipids; D008074:Lipoproteins; D007862:Phosphatidylcholine-Sterol O-Acyltransferase