A neuroendocrine tumor of the small intestine with a karyotype of 46,XY,t(11;22).
Direct preparations of cells from a neuroendocrine carcinoma of the small intestine reveal a karyotype of 46,XY,t(11;22)(q25;q12). Though only 13 cells could be analyzed from both direct and 24 hour preparations, all revealed the translocation; no normal cell line was seen. The patient had not been treated at the time of biopsy. A similar translocation recently has been reported in a number of cases of Ewing's sarcoma and in peripheral neuroepithelioma. This common occurrence, along with the observation that a rearranged chromosome #22 with breakpoints at q11 or q12 are observed in other neoplasias including leukemia, suggests a possible causative role for these phenomena.
Vigfusson
N V
NV
Allen
L J
LJ
Phillips
J H
JH
Alschibaja
T
T
Riches
W G
WG
D002277:Carcinoma / Q000235:genetics* / Q000473:pathology; D002871:Chromosome Banding; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D007078:Ileal Neoplasms / Q000235:genetics* / Q000473:pathology; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000473:pathology; D014178:Translocation, Genetic