Relationship between left ventricular systolic function and plasma clearance of 169Yb-DTPA in normal and ischemic dogs.
Plasma clearance of 169Yb-DTPA, a heavy chelate metal excreted only by glomerular filtration, was measured serially in a canine model to determine whether the clearance of this substance correlates with left ventricular systolic function. Fourteen anesthetized open-chest dogs were studied. Six dogs (group I) were used to estimate the clearance of 169Yb-DTPA in the setting of normal left ventricular function. Eight dogs (group II) were used to estimate clearance of 169Yb-DTPA in the presence of ischemic left ventricular dysfunction. Cardiac output, mean arterial pressure, and plasma levels of 169Yb-DTPA were measured serially. In group II dogs, area at risk for necrosis was defined using myocardial contrast echocardiography. The change in clearance of 169Yb-DTPA in group II dogs correlated well with change in cardiac output and area at risk (r = 0.80 and -0.93, respectively) and was significantly different from group I dogs (p less than 0.01). However, changes in clearance of 169Yb-DTPA in the group II dogs did not correlate well with change in mean arterial pressure (r = 0.26).


CONCLUSIONS
(1) clearance of 169Yb-DTPA is constant over time in the absence of ischemic left ventricular dysfunction and derangement of other hemodynamic parameters; (2) changes in clearance of 169Yb-DTPA correlate well with changes in systolic pump function and left ventricular area at risk in the setting of ischemic left ventricular dysfunction, and (3) clearance of 169Yb-DTPA is not related to mean arterial pressure.
Department of Medicine, University of Virginia School of Medicine, Charlottesville.
S
S
Kaul
D D
DD
Watson
J D
JD
Oliner
R D
RD
Okada
A E
AE
Weyman
H W
HW
Strauss
D000818:Animals; D001794:Blood Pressure; D003327:Coronary Disease / Q000097:blood / Q000503:physiopathology*; D004285:Dogs; D005919:Glomerular Filtration Rate; D006339:Heart Rate; D004369:Pentetic Acid / Q000097:blood* / Q000493:pharmacokinetics; D011868:Radioisotopes / Q000097:blood; D013318:Stroke Volume; D015018:Ytterbium / Q000097:blood* / Q000493:pharmacokinetics
D011868:Radioisotopes; D004369:Pentetic Acid; D015018:Ytterbium