Influence of nitrous oxide upon regional brain levels of methionine-enkephalin-like immunoreactivity in rats.
The influence of a 60-min exposure to 75% nitrous oxide/25% oxygen upon concentrations of methionine-enkephalin-like immunoreactivity (MELI) in discrete brain regions was investigated in conscious rats. Compared to room air-exposed control animals, nitrous oxide-exposed rats had 12-18% increases in MELI in the brainstem, spinal cord, hypothalamus and corpus striatum. There were no significant differences between control and nitrous oxide-exposed rats in levels of MELI in the cerebral cortex or diencephalon.
R M
RM
Quock
F J
FJ
Kouchich
L F
LF
Tseng
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000378:metabolism*; D008297:Male; D009609:Nitrous Oxide / Q000494:pharmacology*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D004744:Enkephalin, Methionine; D009609:Nitrous Oxide