The effect of cholestyramine on apolipoproteins in cholesterol-fed rabbits.
The changes in apolipoproteins on cholestyramine therapy associated with cholesterol feeding were compared to those observed in cholesterol-fed rabbits. Only one molecular species of apo B, identified as apo B-100, was present whatever the dietary or pharmacological treatment indicating the hepatic origin of apo B-containing lipoproteins in these conditions. Cholestyramine has a clear preventive effect on the rise of apo B and apo E which appear following cholesterol feeding. These changes are highly correlated with those of the plasma cholesterol level. In addition, cholestyramine induced a 50% increase in apo AI compared with normal rabbits. These data strongly confirm the beneficial effects of cholestyramine in the treatment of hypercholesterolemia.
Lacombe
C
C
Corraze
G
G
Nibbelink
M
M
D000818:Animals; D001053:Apolipoproteins / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood; D001057:Apolipoproteins E / Q000097:blood; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D002792:Cholestyramine Resin / Q000008:administration & dosage / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel; D006937:Hypercholesterolemia / Q000517:prevention & control; D008297:Male; D011817:Rabbits
D001053:Apolipoproteins; D001055:Apolipoproteins B; D001057:Apolipoproteins E; D002791:Cholesterol, Dietary; D002792:Cholestyramine Resin; D002784:Cholesterol