In vivo voltammetric study of dopamine release in the striatum following microinjection of apomorphine into the substantia nigra zona reticulata.
Effect of microinjection of apomorphine into the substantia nigra zona reticulata (SNR) on the dopamine (DA) release in the ipsilateral striatum was examined in the present study. To measure the DA release, we determined DA and/or DOPAC levels in the striatum by using in vivo voltammetry. The microinjection of apomorphine (10 micrograms/2 microliters) into the SNR produced a rapid and prolonged increase in the DA and/or DOPAC peak in the ipsilateral striatum. These results suggest that release of DA from dendrites of DA cells normally plays a physiological role in the SNR neurons.
K
K
Kamata
A
A
Sugimoto
T
T
Kameyama
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002421:Caudate Nucleus / Q000032:analysis / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008845:Microinjections; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D012701:Serotonin / Q000032:analysis; D013378:Substantia Nigra / Q000187:drug effects* / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D011954:Receptors, Dopamine; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D000661:Amphetamine; D001058:Apomorphine; D004298:Dopamine