[Effect of kyotorphin on the reactivity of hippocampal neurons].
The effects of kyotorphin (Tyr-Arg) on CA1 and CA3 field responses were studied on rat hippocampal slice preparations. Slice perfusion with 10(-6)-10(-4) M of kyotorphin resulted in reactivity changes both in mossy fibers (CA3) and Schaffer collaterals (CA1). The principal effect was the increase in pop-spike amplitude. Kyotrophin (10(-6)-10(-5) M) and metenkephalin (10(-7)-10(-6) M) were found to produce similar reactivity changes (facilitation) in CA1 region of most preparations. However, kyotorphin effect, in contrast to enkephalin-induced facilitation was not blocked by naloxone. The data suggest that the mechanisms of kyotorphin action in the hippocamp are not related to endogenous enkephalin release.
Chepkova
A N
AN
Zotov
V M
VM
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004558:Electric Stimulation; D004723:Endorphins / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D009270:Naloxone / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D004723:Endorphins; C019448:kyotorphin; D009270:Naloxone; D004744:Enkephalin, Methionine
Deĭstvie kiotorfina na reaktivnost' neĭronov gippokampa.