Characteristics of analgesia induced by adenosine triphosphate.
Adenosine triphosphate (ATP) injected intravenously in mice was found to have dose-dependent analgesic activity in the hot plate and phenylquinone-induced stretching assays. ATP prolonged the hot plate latency (ED50 value of 1 (0.7-1.4) mg/kg) and inhibited phenylquinone-induced writhing (ED50 value of 0.4 (0.31-0.52) mg/kg). Low doses of ATP produced a potent antinociceptive effect without any significant depression of locomotor activity. Treatment of mice for either 4 days or 14 days with ATP did not result in development of physical dependence on or tolerance to ATP. The analgesic action of ATP was not antagonized by naloxone at 1 and 5 mg/kg. ATP analgesia was antagonized, in a dose-related fashion, by Ca++ ion injected intracerbroventricularly which may indicate that Ca++ plays a role in ATP-induced antinociception.
Department of Pharmacology, Faculty of Medicine, Assiut University, Egypt.
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Gomaa
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000700:Analgesics; D000818:Animals; D016227:Benzoquinones; D002122:Calcium Chloride / Q000494:pharmacology; D004361:Drug Tolerance; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010146:Pain / Q000139:chemically induced; D011809:Quinones; D011930:Reaction Time / Q000187:drug effects; D019966:Substance-Related Disorders / Q000523:psychology
D000700:Analgesics; D016227:Benzoquinones; D011809:Quinones; C029322:phenylbenzoquinone; D000255:Adenosine Triphosphate; D002122:Calcium Chloride