Heritability of plasma cholesterol and triglyceride concentrations in swine.
Three-hundred and eighteen female swine representing contemporary commercial swine breeds (34 Chester White, 43 Large White, 42 Landrace, 40 Yorkshire, and 159 four-breed crossbreeds) were used to evaluate genetic variation between and within breeds for levels of plasma cholesterol and plasma triglycerides. Blood was sampled from all pigs after a 16-hr fast at 154 days of age. Plasma cholesterol was measured in all pigs and triglycerides were measured in 232 pigs. Paternal half-sib heritabilities (h2) for plasma cholesterol and plasma triglycerides were 0.45 +/- 0.23 and 1.04 +/- 0.32, respectively. Breed differences were not apparent for either trait. Phenotypic and paternal half-sib genetic correlations between the two traits were 0.16 and 0.66, respectively. Neither body weight nor backfat depth were important in affecting the estimate of h2 for either trait. The relatively high h2 of total plasma cholesterol and of total triglycerides offers the possibility of developing, through selection, populations of hypercholesterolemic or hypertriglyceridemic swine useful as models for studies directed toward further understanding of human cardiovascular disease.
Pond
W G
WG
Mersmann
H J
HJ
Young
L D
LD
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D005260:Female; D013552:Swine / Q000097:blood* / Q000235:genetics; D014280:Triglycerides / Q000097:blood*
D014280:Triglycerides; D002784:Cholesterol