Effects of pyridoxine on implantation and pregnancy in Wistar rat.
Pyridoxine hydrochloride was gavaged to 2 groups of pregnant Wistar rats from day 0 to 13 and day 6 to 15 of gestation at doses of 100, 200, 400 and 800 mg/kg. A higher number of implantations, live pups and corpora lutea were observed in the treated rats, but a significant reduction in the body weights of the pups was noticed in the groups treated with 400 and 800 mg/kg. No other adverse effects on implantation and pregnancy were noticed. No evidence of dismorphogenic effects was seen.
IDPL Research Centre, Hyderabad, India.
M R
MR
Marathe
G P
GP
Thomas
D000818:Animals; D010064:Embryo Implantation / Q000187:drug effects*; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011736:Pyridoxine / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D011736:Pyridoxine