Multiple hamartoma syndrome (Cowden's disease) associated with non-Hodgkin's lymphoma.
A 70-year-old woman with the multiple hamartoma syndrome is described. Diagnosis was based on the clinical presentation and histopathologic examination of cutaneous trichilemmomas. The case is reported to document the association of Cowden's disease with non-Hodgkin's lymphoma. This is the first known report of the occurrence of trichilemmomas in the sacral area. The literature concerning the association of the multiple hamartoma syndrome with malignancy is reviewed.
D M
DM
Elston
W D
WD
James
O G
OG
Rodman
G F
GF
Graham
D000368:Aged; D005260:Female; D006222:Hamartoma / Q000473:pathology*; D006801:Humans; D008223:Lymphoma / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*