Intestinal absorption and metabolism of homoursodeoxycholic acid in rats.
Intestinal absorption, hepatic biotransformation and intestinal bacterial modification of the C25 homolog of ursodeoxycholic acid, homoursodeoxycholic acid, and its glycine conjugate, glycohomoursodeoxycholic acid, were studied in rats. Homoursodeoxycholic acid, like ursodeoxycholic acid, was efficiently absorbed from the intestine and rapidly excreted into the bile. Most (greater than 95%) of the absorbed homoursodeoxycholic acid was found to undergo beta-oxidation to form two C23 bile acids, norursodeoxycholic acid and nor-beta-muricholic acid during passage through the liver. Bacterial modification of homoursodeoxycholic acid was very similar to that of ursodeoxycholic acid. In the rat intestinal tract, glycohomoursodexycholic acid was deconjugated to form unconjugated homoursodeoxycholic acid which was then 7 beta-dehydroxylated to form homolithocholic acid.
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Minamiku, Japan.
T
T
Kuramoto
S
S
Moriwaki
K
K
Kawamoto
T
T
Hoshita
D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003840:Deoxycholic Acid / Q000031:analogs & derivatives*; D007408:Intestinal Absorption; D007422:Intestines / Q000382:microbiology; D008099:Liver / Q000378:metabolism; D051381:Rats; D014580:Ursodeoxycholic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D003840:Deoxycholic Acid; C047112:homoursodeoxycholic acid; D014580:Ursodeoxycholic Acid