The effect of two new glucosidase inhibitors on blood glucose in healthy volunteers and in type II diabetics.
Two new glucosidase inhibitors (BAY m 1099 and BAY o 1248) were studied in volunteers and type II diabetics under various conditions. In 6 non-diabetic controls BAY m 1099 when given 3 X 50 mg/day caused a marked depression of the post-meal glucose rise. The effect was found to be more marked after breakfast than after lunch or after dinner. In type II diabetics BAY m 1099, when given in a dose of 2 X 25 mg/day over one week, had no significant effect on post-meal glucose or serum insulin levels. BAY o 1248, when given as a single dose of 15 mg in the morning to type II diabetics, induced a significant decrease of post-meal glucose rise (35 mg/dl after breakfast, 25 mg/dl after lunch) when compared to placebo. Although in parallel serum insulin levels were slightly lower, this change was statistically not significant. The drug reduced glycosuria by 50%. Both compounds induced side effects, such as flatulence or diarrhea when given in therapeutically effective amounts, but were tolerable in most cases. On a weight basis BAY o 1248 was found to have greater therapeutic effects than BAY m 1099. Both drugs can be recommended for use in unsatisfactorily controlled type II diabetics. Further studies should concentrate on the critical dosage which may strike a satisfactory balance between effects and side effects.
Federlin
K F
KF
III. Medizinische Klinik und Poliklinik, Universität Giessen, FRG.
Mehlburger
L
L
Hillebrand
I
I
Laube
H
H
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D004311:Double-Blind Method; D005260:Female; D005944:Glucosamine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D006801:Humans; D050112:Imino Pyranoses; D008297:Male; D008875:Middle Aged
D000900:Anti-Bacterial Agents; D001786:Blood Glucose; D050112:Imino Pyranoses; C045621:miglitol; D017485:1-Deoxynojirimycin; D005959:Glucosidases; D005944:Glucosamine; C045622:emiglitate