[Differences in the reaction of rat and guinea pig hearts to ischemia and reperfusion].
The response of rat and guinea-pig hearts to ischemia and reperfusion has been studied in identical conditions. Total 15-min ischemia of isolated rat hearts at 36 degrees C induced an almost 3-fold rise in isovolumic left ventricular diastolic pressure as well as a fall in the developed pressure and heart rate. Guinea-pig hearts, in the same conditions, exhibited a more steep fall in heart rate, with no rise in diastolic pressure. With constant heart rate produced by electrical stimulation at 4 Hz, the difference between two groups remained unchanged, while a more rapid fall in developed pressure in guinea-pig hearts coincided with a more profound fall in extracellular pH and almost a 2-fold rise in extracellular K+ activity. Rapid elimination of K+ and H+ at the early stages of reperfusion was followed by fibrillation in the majority of guinea-pig hearts, while no fibrillation was observed in rat hearts.
Shul'zhenko
V S
VS
Pukhova
T M
TM
Khatkevich
A N
AN
Kapel'ko
V I
VI
D000818:Animals; D003327:Coronary Disease / Q000503:physiopathology*; D003971:Diastole; D004734:Energy Metabolism; D005110:Extracellular Space / Q000378:metabolism; D006168:Guinea Pigs; D006859:Hydrogen / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D009200:Myocardial Contraction; D011188:Potassium / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D006859:Hydrogen; D011188:Potassium
Razlichiia v reaktsii serdets krys i morskikh svinok na ishemiiu i reperfuziiu.