[Induction of substances with thymosin-like activity and the potentiation of interferonogenesis in the mechanism of prodigiozan inhibition of 3-methylcholanthrene-induced blastomogenesis].
It is shown that prodigiosan is an inductor of synthesis of the substances with the thymosin-like activity. The suggestion about inhibition of 3-methylcholanthrene-induced blastomogenesis by prodigiosan which is mediated by the substances with the thymosin-like activity and interferon is discussed. We present the hypothetical diagram of the development of the above mentioned mechanism. The significance of the obtained findings for elaboration of the immunotherapy is discussed.
Grinevich
Iu A
IuA
Nikol'skiĭ
I S
IS
Shevchenko
V P
VP
Chernenko
O D
OD
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D007369:Interferon Inducers; D008748:Methylcholanthrene; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000188:drug therapy / Q000401:mortality; D009929:Organ Size / Q000187:drug effects; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D011354:Prodigiozan / Q000627:therapeutic use*; D051381:Rats; D013154:Spleen / Q000187:drug effects; D013934:Thymectomy; D013947:Thymosin / Q000096:biosynthesis* / Q000097:blood; D013950:Thymus Gland / Q000187:drug effects; D013997:Time Factors
D007369:Interferon Inducers; D011135:Polysaccharides, Bacterial; D008748:Methylcholanthrene; D013947:Thymosin; D011354:Prodigiozan
Induktsiia veshchestv s timozinopodobnoĭ altivnost'iu i potentsirovanie interferonogeneza v mekhanizme tormozheniia prodigiozanom blastomogeneza, indutsirovannogo 3-metilkholantrenom.