The intra- and inter-subject variability of nifedipine pharmacokinetics in young volunteers.
Plasma concentrations of Nifedipine were measured following single oral doses of Nifedipine Slow Release (Adalat Retard) on three separate occasions to young, healthy volunteers of both sexes. Intra- and inter-subject variability were assessed by comparing the pharmacokinetic parameters, AUC, Cmax and T50%AUC. Interindividual variability was less than that observed in other studies with the beta-blockers, metoprolol and propranolol and there was no evidence of differences between the sexes.
Lobo
J
J
Jack
D B
DB
Kendall
M J
MJ
D000328:Adult; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000097:blood*; D012737:Sex Factors
D003692:Delayed-Action Preparations; D009543:Nifedipine