Rapid DNA synthesis by use of a new functionalized 5'-hydroxyl protecting group in the phosphorothio ester approach.
This paper describes a new protecting group of the 5'-hydroxyl group, 3-(imidazol-l-ylmethyl)-4,4'-dimethoxytrityl (IDTr), which serves as potential catalytic site for internucleotide bond formation.
Sekine
M
M
Department of Life Chemistry, Tokyo Institute of Technology, Yokohama, Japan.
Narui
S
S
Hata
T
T
D004247:DNA / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D014320:Triphenylmethyl Compounds
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D014320:Triphenylmethyl Compounds; D004247:DNA