Superoxide dismutase and catalase in Toxoplasma gondii.
Catalase and superoxide dismutase detected in both RH and C strain Toxoplasma gondii tachyzoites were distinctly different in electrophoretic mobility from host cell enzymes. Catalase and superoxide dismutase activity levels were similar in both Toxoplasma strains and showed narrow pH optima around 8.0. Toxoplasma superoxide dismutase was resistant to cyanide but inhibited by azide or peroxide, consistent with an iron-containing enzyme typical of protozoan parasites. These enzymes may play a role in intracellular survival; however, they do not appear to be the basis for differences in virulence to mice.
L D
LD
Sibley
R
R
Lawson
E
E
Weidner
D000818:Animals; D001386:Azides / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism*; D002478:Cells, Cultured; D003486:Cyanides / Q000494:pharmacology; D004592:Electrophoresis, Starch Gel; D006863:Hydrogen-Ion Concentration; D008264:Macrophages / Q000469:parasitology; D051379:Mice; D010545:Peroxides / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism*; D014122:Toxoplasma / Q000201:enzymology* / Q000254:growth & development / Q000472:pathogenicity; D014774:Virulence
D001386:Azides; D003486:Cyanides; D010545:Peroxides; D002374:Catalase; D013482:Superoxide Dismutase