Rapid kindling in the prepubescent rat.
Bipolar electrodes, stereotaxically implanted in the hippocampus and amygdala of prepubescent rats, were used to deliver 1- or 10-s trains of suprathreshold bipolar stimulations at frequencies of 10 or 60 Hz. The stimuli were administered every 5 min. Rapid kindling was achieved with 10-s but not 1-s stimulation with both 10- and 60-Hz frequencies. Ten-s stimulations with a 60-Hz frequency resulted in more rapid kindling than 10-s stimulations with a 10-Hz frequency. The rate of kindling was similar in the hippocampus and amygdala. In the immature animal rapid kindling can be achieved with electrical stimulations with long duration and short interstimulus intervals.
Department of Neurology, Medical College of Georgia, Veteran's Medical Center, Augusta 30912.
G L
GL
Holmes
J L
JL
Thompson
D000679:Amygdala / Q000254:growth & development* / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000254:growth & development* / Q000502:physiology; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology; D012741:Sexual Maturation