Sequential studies of bone marrow haemopoietic progenitors (CFU-GEM, BFU-E, CFU-E, CFU-GM) following busulfan treatment in Balb/c mice.
The effect of multiple sublethal doses of busulfan on the haemopoietic system of the Balb/c mouse was examined. FBC's bone marrow histology and bone marrow progenitor cell assays (CFU-E, BFU-E, CFU-GM and CFU-GEM) were performed. No effect was seen on FBC's or on marrow histology. However there was a significant depletion noted in the number of haemopoietic progenitor cells as measured by in vitro culture.
Reynolds
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McCann
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D000375:Aging; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002066:Busulfan / Q000494:pharmacology*; D002478:Cells, Cultured; D006400:Hematocrit; D006412:Hematopoietic Stem Cells / Q000145:classification / Q000187:drug effects*; D006651:Histocytochemistry; D007958:Leukocyte Count; D051379:Mice; D008807:Mice, Inbred BALB C / Q000502:physiology*; D010976:Platelet Count
D002066:Busulfan