Iron mobilisation from lactoferrin by chelators at physiological pH.
Several alpha-ketohydroxypyridine, 2-hydroxypyridine N-oxide and 8-hydroxyquinoline chelators were shown to mobilise iron from diferric 59Fe-labelled human lactoferrin at physiological pH without the use of mediators or reducing agents. 1,2-Dimethyl-3-hydroxypyrid-4-one was found to be the most effective chelator, removing 90% of 59Fe from [59Fe]lactoferrin, in contrast to desferrioxamine, which was ineffective under the same conditions.
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Kontoghiorghes
D002614:Chelating Agents / Q000378:metabolism; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000378:metabolism*; D007781:Lactoferrin / Q000302:isolation & purification / Q000378:metabolism*; D007782:Lactoglobulins / Q000378:metabolism*; D008895:Milk, Human / Q000032:analysis
D002614:Chelating Agents; D007782:Lactoglobulins; D007501:Iron; D007781:Lactoferrin