Manic-like reaction induced by lorazepam withdrawal.
The benzodiazepine withdrawal symptoms are presented here. The psychotic reactions to benzodiazepine withdrawal are seldom described in the literature. We report a case of acute manic-like reaction induced by sudden lorazepam withdrawal. The sudden release of catecholamines following abrupt cessation of short half-life benzodiazepine is suggested as underlying mechanism for such reaction.
University of Ottawa, Ontario.
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YD
Lapierre
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A
Labelle
D001008:Anxiety Disorders / Q000188:drug therapy*; D001714:Bipolar Disorder / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D008140:Lorazepam