Carcinogenicity and cocarcinogenicity test of phenobarbital sodium in adult BALB/c mice.
The carcinogenic and cocarcinogenic action of phenobarbital sodium was investigated in adult BALB/c mice of both sexes when administered alone at a concentration of 0.05% in drinking water for life or after the animals had been treated with a single hydrazine sulphate dose of 5.65 mg. The results demonstrated that phenobarbital sodium is not carcinogenic in this strain of mice, but, since a single dose of hydrazine sulphate was carcinogenic, does not clarify whether it is a cocarcinogen in the lung.
Cavaliere
A
A
Bufalari
A
A
Vitali
R
R
D000818:Animals; D003043:Cocarcinogenesis; D005260:Female; D006834:Hydrazines / Q000633:toxicity; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010634:Phenobarbital / Q000633:toxicity*
D006834:Hydrazines; C029424:hydrazine; D010634:Phenobarbital