[Galenic and clinico-pharmacologic studies of prednicarbate (Hoe 777)].
The corticoid prednicarbate (test name: Hoe 777) is derived from prednisolone having no halogenic groups (chemical name: prednisolone-17-ethyl carbonate-21-propionate). Because of the specific physical and chemical properties of prednicarbate, galenic research strove to optimize the vehicle. Further development was only performed on those drug-containing bases showing especially good drug release (granting the most favorable action) in a) the vasoconstriction test and b) the UV erythema test practiced on volunteers with healthy skin. Exemplarily dealing with the special preparations predicarbate cream, ointment, and greasy ointment, we give some details of studies on drug dosage, vehicle selection, and the optimum water/lipid ratio.
W
W
Petri
P J
PJ
Frosch
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C
Savopoulos
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W
Rupp
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W
Sittig
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D055598:Chemical Phenomena; D002621:Chemistry; D003872:Dermatitis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D014677:Pharmaceutical Vehicles; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012869:Skin Absorption / Q000187:drug effects; D013471:Sunburn / Q000188:drug therapy; D014661:Vasoconstriction / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D014677:Pharmaceutical Vehicles; D011239:Prednisolone; C035287:prednicarbate
Galenische und klinisch-pharmakologische Untersuchungen zu Prednicarbat (Hoe 777).