Treatment of hepatic metastases in ocular melanoma. Embolization of the hepatic artery with polyvinyl sponge and cisplatin.
Patients with ocular melanoma have a high incidence of hepatic metastases, which primarily determine their length of survival. In an attempt to control the neoplastic disease in the liver, embolization of the hepatic artery with a combination of polyvinyl sponge (Ivalon) and a suspension of cisplatin was performed in two patients with hepatic metastases from ocular melanoma. Dramatic regression of the hepatic metastases, lasting 19 and six months, occurred in these two patients after one or two such treatments. Our preliminary, albeit successful, experience with this therapeutic approach suggests that it may offer relatively prolonged periods of remission and warrants further investigation.
Carrasco
C H
CH
Wallace
S
S
Charnsangavej
C
C
Papadopoulos
N E
NE
Patt
Y Z
YZ
Mavligit
G M
GM
D000328:Adult; D002830:Choroid Neoplasms; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary / Q000628:therapy*; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging / Q000556:secondary / Q000628:therapy*; D011145:Polyvinyls; D013535:Suspensions; D014057:Tomography, X-Ray Computed
D011145:Polyvinyls; D013535:Suspensions; C026699:ivalon sponge; D002945:Cisplatin