Tricyclo[4.2.2.0(2,5)]dec-9-ene-3,4,7,8-tetracarboxylic acid diimide: formulation and stability studies.
The experimental antitumor drug, tricyclo[4.2.2.0(2,5)]dec-9-ene-3,4,7,8-tetracarboxylic acid diimide, NSC 284356, was formulated as the disodium salt in a stable freeze-dried form suitable for parenteral administration. The stability of the drug was determined in buffers at various temperatures using liquid chromatography. The drug was found to undergo hydrolysis in aqueous solutions. The rate of hydrolysis followed pseudo-first-order kinetics and is accelerated by increases in temperature and pH of the solutions. The hydrolysis product was isolated, and its structure was determined by unambiguous chemical methods.
B R
BR
Vishnuvajjala
J C
JC
Cradock
D000970:Antineoplastic Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004339:Drug Compounding; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000032:analysis*; D054833:Isoindoles; D007700:Kinetics; D010084:Oxidation-Reduction; D013696:Temperature; D014961:X-Ray Diffraction
D000970:Antineoplastic Agents; D007211:Indoles; D054833:Isoindoles; C047749:mitindomide