Imaging of experimental amyloidosis with 131I-labeled serum amyloid P component.
131I-labeled human serum amyloid P component, which was injected into mice with experimentally induced systemic AA amyloidosis and into controls, became specifically localized and was retained in amyloidotic organs. In comparison, it was rapidly and completely eliminated from unaffected tissues and from control animals. Distinctive images of this amyloid-specific deposition of labeled serum amyloid P component were derived from whole body scanning, in vivo, of amyloidotic mice. These findings suggest that such imaging may have applications for the diagnosis and quantitation of amyloid deposits in humans.
Caspi
D
D
Ichilov Hospital, Tel Aviv University, Sackler School of Medicine, Israel.
Zalzman
S
S
Baratz
M
M
Teitelbaum
Z
Z
Yaron
M
M
Pras
M
M
Baltz
M L
ML
Pepys
M B
MB
D000686:Amyloidosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D000818:Animals; D005260:Female; D007279:Injections, Subcutaneous; D007457:Iodine Radioisotopes; D008297:Male; D051379:Mice; D011877:Radionuclide Imaging; D000683:Serum Amyloid P-Component / Q000633:toxicity*; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D000683:Serum Amyloid P-Component