Okilactomycin, a novel antibiotic produced by a Streptomyces species. I. Taxonomy, fermentation, isolation and characterization.
Okilactomycin, a novel antibiotic, was isolated from the culture filtrate of a strain of actinomycetes. The producing organism, strain YP-02908L, was identified as Streptomyces griseoflavus subsp. zamamiensis subsp. nov. The antibiotic was extracted with ethyl acetate and purified by silica gel column chromatography. It was obtained as colorless prisms from a dichloromethane solution. It exhibited weak antimicrobial activity against Ehrlich ascites carcinoma in vivo. The apparent molecular formula of okilactomycin was determined as C24H32O6. It is a new member of the lactone group antibiotics.
Imai
H
H
Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
Suzuki
K
K
Morioka
M
M
Numasaki
Y
Y
Kadota
S
S
Nagai
K
K
Sato
T
T
Iwanami
M
M
Saito
T
T
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007274:Injections, Intraperitoneal; D007783:Lactones / Q000032:analysis / Q000302:isolation & purification / Q000627:therapeutic use; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D007783:Lactones; C054471:okilactomycin