[Ethanol and malondialdehyde levels and activity of ethanol-oxidizing system in the serum of patients with alcoholism treated with teturamin].
222 patients with chronic alcoholism (the second step of the disease) at the state of abstination and in the period of alcohol consumption were studied. In the course of treatment the patients received about 0.5 g of teturam per day within 4 months. In blood serum of the patients content of ethanol, malonic dialdehyde and activity of ethanol-oxidizing system (EOS) were estimated. In practically healthy persons, consuming no ethanol, no activity of EOS was noted as a rule. But in the patients with chronic alcoholism activity of EOS was 100-fold increased with simultaneous elevation in ethanol and malonic dialdehyde content in blood serum. After treatment with teturam content of ethanol, malonic dialdehyde and, especially, activity of the EOS were decreased in blood of the patients. After the treatment during 4 months activity of EOS was still distinctly higher in the patients than in healthy persons.
Mansurova
I D
ID
Istamkulov
M S
MS
D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000188:drug therapy; D004221:Disulfiram / Q000009:adverse effects / Q000627:therapeutic use*; D000431:Ethanol / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008314:Malonates / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D010084:Oxidation-Reduction; D013997:Time Factors
D008314:Malonates; D000431:Ethanol; D008315:Malondialdehyde; D004221:Disulfiram
Soderzhanie étanola, malonovogo dial'degida i aktivnost' étanolokisliaiushcheĭ sistemy v syvorotke krovi bol'nykh alkogolizmom pri lechenii teturamom.