A novel macrolide antibiotic, notonesomycin A.
Fermentation of Streptomyces aminophilus subsp. notonesogenes 647-AV1 produced a mixture of antifungal antibiotics. Notonesomycin A, the main component has been characterized as a new macrolide antibiotic containing a sulfate group, a malonate moiety, two deoxysugars and a 1,3,4-trisubstituted benzene system in the molecule. It was active against some fungi and Gram-positive bacteria in vitro and effective against the sheath blight disease of rice plant in a green house test.
Sasaki
T
T
Furihata
K
K
Shimazu
A
A
Seto
H
H
Iwata
M
M
Watanabe
T
T
Otake
N
N
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013302:Streptomyces / Q000145:classification / Q000378:metabolism
D000900:Anti-Bacterial Agents; D006027:Glycosides; D018942:Macrolides; C049332:notonesomycin A