A versatile strategy for the O4-protection and modification of the lactam function of uridine and uridylic acid.
A set of O4-aryl groups has been proposed which can both protect the lactam functions of uridine from electrophilic attacks during nucleic acid synthesis, and also serve as a good leaving group for site-specific modification at C4, under a nucleophilic reaction condition.
Nyilas
A
A
Department of Bio-organic Chemistry, University of Uppsala, Sweden.
Zhou
X X
XX
Welch
C J
CJ
Chattopadhyaya
J
J
D007202:Indicators and Reagents; D007769:Lactams; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D014500:Uracil Nucleotides; D014529:Uridine / Q000031:analogs & derivatives; D014542:Uridine Monophosphate / Q000031:analogs & derivatives
D007202:Indicators and Reagents; D007769:Lactams; D009843:Oligoribonucleotides; D014500:Uracil Nucleotides; D014542:Uridine Monophosphate; D014529:Uridine