[Role of neutrophils and macrophages in localizing purulent infection].
Early stages of bordering the focus of purulent and aseptic inflammation in man and in experimental animals are studied with a particular analysis of the role of polynuclear neutrophils (PNN) and macrophages (MP) in this process. Two variants of a purulent inflammation are studied: widespread diffuse (peritonitis) and circumscribed (abscess). Aseptic diffuse peritonitis and circuscribed inflammation of muscles are studied as control. Methods of light and electron microscopy are used. It is shown that in a purulent and aseptic inflammation a phylogenetically predetermined reaction develops which is directed to the localization and limitation of an inflammatory focus. This response is brought about by blood cells--PNN and MP--between which an interconnection exists stipulated by their function. PNN are the first to appear in the inflammatory focus and their main function is to reveal the presence or the absence of the infection, localization and destruction of bacteria. Macrophages appear in the inflammatory focus later, their function is in the circumscription of the focus and in the stimulation of the connective tissue capsula around the purulent zone or the development of scar in the aseptic inflammation.
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Paukov
D000038:Abscess / Q000473:pathology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002452:Cell Count; D006168:Guinea Pigs; D006614:Hindlimb; D006801:Humans; D008264:Macrophages / Q000473:pathology*; D008854:Microscopy, Electron; D009220:Myositis / Q000473:pathology*; D009504:Neutrophils / Q000473:pathology*; D010538:Peritonitis / Q000473:pathology* / Q000628:therapy; D051381:Rats; D013492:Suppuration / Q000473:pathology*
D000900:Anti-Bacterial Agents
Rol' neĭtrofilov i makrofagov v lokalizatsii gnoerodnoĭ infektsii.