[Antigenic and biological characteristics of influenza virus A strains isolated in 1985].
The antigenic structure of hemagglutinin of influenza A virus (H3N2) strains isolated in 1985 was studied using a series of monoclonal antibody to A/Dunedin/4/73/A (H3N2) and A/Bangkok/1/79/A (H3N2), and biological and physico-chemical properties of these strains were compared with those of influenza A (H3N2) virus of 1983 and reference A (H3N2) of 1979-1984 (the rate of adsorption on chick erythrocytes and eluting activity, thermostability of hemagglutinin and neuraminidase, sensitivity to nonionic detergents, sensitivity to remantadine, analysis of virion polypeptide composition). A high degree of heterogeneity of the 1985 strain population of influenza A (H3N2) virus was revealed both in the antigenic structure of hemagglutinin and in all the biological and physico-chemical parameters tested. It was suggested that the A/Caen/1/84 strain originated not from A/Philippines/2/82 but directly from A/Texas/1/77.
Shenderovich
S F
SF
Iakhno
M A
MA
Ivanova
V T
VT
Liubovtseva
O V
OV
Isachenko
V A
VA
D000327:Adsorption; D000911:Antibodies, Monoclonal / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004591:Electrophoresis, Polyacrylamide Gel; D006385:Hemagglutination Inhibition Tests; D006389:Hemagglutinins, Viral / Q000032:analysis; D006801:Humans; D009980:Influenza A virus / Q000032:analysis / Q000187:drug effects / Q000276:immunology* / Q000302:isolation & purification; D012299:Rimantadine / Q000494:pharmacology; D014764:Viral Proteins / Q000032:analysis
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D006389:Hemagglutinins, Viral; D014764:Viral Proteins; D012299:Rimantadine
Antigennye i biologicheskie osobennosti shtammov virusa grippa A, izolirovannykh v 1985 g.