Pharmacokinetics of parenteral ticarcillin formulated with clavulanic acid: Timentin.
The pharmacokinetics of a formulation of clavulanate potentiated ticarcillin (Timentin) have been investigated following a bolus intravenous injection of 1.2 g, infusions of 3.2 g over periods ranging from 30 minutes to three hours, and a bolus dose of 1.2 g followed by an infusion of 3.2 g. The effect of probenecid has also been investigated. The serum levels of clavulanic acid are discussed in relation to the microbiology and therapeutic implications.
D H
DH
Staniforth
P E
PE
Coates
B E
BE
Davies
R
R
Horton
D001419:Bacteria / Q000187:drug effects; D002969:Clavulanic Acids / Q000009:adverse effects / Q000378:metabolism* / Q000494:pharmacology; D004338:Drug Combinations / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007700:Kinetics; D010406:Penicillins / Q000378:metabolism*; D011339:Probenecid / Q000494:pharmacology; D013982:Ticarcillin / Q000009:adverse effects / Q000378:metabolism* / Q000494:pharmacology
D002969:Clavulanic Acids; D004338:Drug Combinations; D010406:Penicillins; C043215:ticarcillin-clavulanic acid; D013982:Ticarcillin; D011339:Probenecid