Induction of mutants resistant to antibiotics in Brevibacterium flavum.
The optimum conditions for the induction of mutants resistant to antibiotics in Brevibacterium flavum ATCC 14067 were determined. UV irradiation at the energy fluence of 6.5 kJ/m2 and N-methyl-N'-nitro-N-nitrosoguanidine (1 mg/mL) at pH 6.0 were used for the induction of mutants. Mutant strains resistant to rifampicin, oleandomycin, streptomycin and erythromycin were prepared.
Konícek
J
J
Konícková-Radochová
M
M
Rytír
V
V
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001951:Brevibacterium / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009154:Mutation; D009355:Neomycin / Q000494:pharmacology; D009827:Oleandomycin / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D013307:Streptomycin / Q000494:pharmacology; D014466:Ultraviolet Rays; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D008769:Methylnitronitrosoguanidine; D004917:Erythromycin; D014640:Vancomycin; D009355:Neomycin; D009827:Oleandomycin; D012293:Rifampin; D013307:Streptomycin