The early origin of vertebral anomalies, as illustrated by a 'butterfly vertebra'.
An anomalous (butterfly) eleventh thoracic vertebra in a fetus of 63 mm greatest length is described and graphic reconstructions (together with normal controls) are provided. The cartilaginous hemicentra are separated by disc-like material. Cartilaginous bars to adjacent vertebrae are present. The neural arch is complete. The notochord is not duplicated. Only one comparable case in the embryonic period has been described previously. After a discussion of cleft vertebrae in the human and in experimental animals, a developmental timetable of the appearance of several vertebral anomalies is provided. The sensitive period for butterfly vertebrae, depending on the mode of origin, seems to be 3-6 postovulatory weeks. More severe anomalies, such as the split notochord syndrome, appear earlier. It is concluded that most of the vertebral anomalies discussed arise during the embryonic period proper, although the timing of a few, such as spina bifida occulta, extends into the early fetal period.
Carnegie Laboratories of Embryology, California Primate Research Centre, Davis.
F
F
Müller
R
R
O'Rahilly
D R
DR
Benson
D001158:Arteries / Q000002:abnormalities / Q000196:embryology; D002113:Calcification, Physiologic; D005333:Fetus / Q000033:anatomy & histology*; D006801:Humans; D007403:Intervertebral Disc / Q000196:embryology; D009672:Notochord / Q000033:anatomy & histology; D011859:Radiography; D012272:Ribs / Q000196:embryology; D013131:Spine / Q000098:blood supply / Q000196:embryology; D013904:Thoracic Vertebrae / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000196:embryology