Chlorpropamide overdose in renal failure: management with charcoal hemoperfusion.
A potentially lethal chlorpropamide overdose in a patient with chronic renal failure on long-term hemodialysis was treated by two courses of charcoal hemoperfusion. Hemoperfusion shortened the half-life clearance of the drug from a mean value of 93.6 to 3.4 hours. Calculation of the fractional extraction indicated that hemoperfusion reduced the body burden of the drug by 24% and 19% (mean values) during the first and second hours of treatment, respectively. We conclude that charcoal hemoperfusion should be considered a definitive therapeutic option in such cases.
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
S M
SM
Ludwig
J
J
McKenzie
C
C
Faiman
D000328:Adult; D002606:Charcoal / Q000627:therapeutic use*; D002747:Chlorpropamide / Q000097:blood / Q000506:poisoning*; D005069:Evaluation Studies as Topic; D006207:Half-Life; D006464:Hemoperfusion; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000628:therapy; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D006435:Renal Dialysis
D002606:Charcoal; D002747:Chlorpropamide