Resolution of some enantiomeric amines of forensic interest by high-performance liquid chromatography.
The high-performance liquid chromatographic resolution of the enantiomers of amphetamine, methamphetamine, ephedrine, and pseudoephedrine is described. The sugar isothiocyanate, 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate (GITC), is used as a chiral derivatizing agent, with chromatographic separations of the diastereomers formed with each amine made using a standard achiral C18 stationary phase.
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D000588:Amines / Q000032:analysis*; D000661:Amphetamine / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D004809:Ephedrine / Q000032:analysis; D005554:Forensic Medicine; D006801:Humans; D007536:Isomerism; D008694:Methamphetamine / Q000032:analysis; D010665:Phenylpropanolamine / Q000032:analysis; D013329:Structure-Activity Relationship
D000588:Amines; D010665:Phenylpropanolamine; D008694:Methamphetamine; D000661:Amphetamine; D004809:Ephedrine