Toxicological studies in a Distalgesic addict.
The disposition and kinetics of paracetamol, dextropropoxyphene and their metabolites were investigated in an addict who claimed to be taking 80-100 Distalgesic tablets daily regularly. Plasma concentrations of paracetamol, dextropropoxyphene and their principal metabolites were measured after an oral dose of 15 Distalgesic tablets. The absorption of paracetamol and dextropropoxyphene was rapid with peak plasma concentrations at 15 and 30 min respectively. The elimination half-life for paracetamol was 2.3 h. Nordextropropoxyphene remained at steady state with very high plasma concentrations (5 mg/l). The urinary excretion of paracetamol and metabolites was not abnormal. The total recovery of paracetamol was only 31% of the dose. Apart from raised plasma gamma-glutamyltransferase activity there was no biochemical evidence for paracetamol-induced hepatocellular damage despite ingestion of 97.5 g of paracetamol over the 11 days of the withdrawal period.
Roberts
I
I
Flanagan
R J
RJ
Strang
J
J
Prescott
L F
LF
D000082:Acetaminophen / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism* / Q000652:urine; D000328:Adult; D011431:Dextropropoxyphene / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004338:Drug Combinations / Q000097:blood / Q000378:metabolism / Q000652:urine; D006801:Humans; D007700:Kinetics; D008297:Male; D019966:Substance-Related Disorders / Q000378:metabolism*
D004338:Drug Combinations; D000082:Acetaminophen; C011800:acetaminophen, dextropropoxyphene, drug combination; C037386:acetaminophen glucuronide; D011431:Dextropropoxyphene; C045667:acetaminophen sulfate ester