Sulfatroxazole: pharmacokinetics, metabolism and urinary excretion in goats and pigs.
The disposition of sulfatroxazole (STZ) has been studied in goats and pigs after intravenous administration of a single dose. The percentage of protein-binding decreased with increasing plasma concentration in both species. At 100 micrograms/ml about 85% was bound to plasma proteins in goats, while the corresponding value was only 55% in pigs. Two metabolites of STZ were isolated from urine and identified as N4-acetyl-STZ and 3-sulfanilamido-4-methyl-5-hydroxy-methyl-isoxazole (5'-OH-STZ). The goats excreted about 80% of the dose in urine. The majority (64%) was excreted as unchanged STZ, while N4-acetyl-STZ and 5'-OH-STZ made up 19% and 18%, respectively. The pigs excreted 95% of the dose in urine. Unchanged STZ amounted to 30% and N4-acetyl-STZ to 70% of the urinary excretion in pigs, while there were only traces of 5'-OH-STZ.
Kinabo
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LD
Nielsen
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D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D006041:Goats / Q000378:metabolism*; D007275:Injections, Intravenous; D007700:Kinetics; D013058:Mass Spectrometry; D011485:Protein Binding; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000652:urine; D013552:Swine / Q000378:metabolism*
D001798:Blood Proteins; D013420:Sulfamethoxazole; C048358:sulfatroxazole