Antisera to an axolemma-enriched fraction inhibit neurite outgrowth and destroy axons in vitro.
Antisera prepared to an axolemma-enriched fraction derived from rat brain inhibited neurite outgrowth and destroyed mature axons in spinal cord-dorsal root ganglia cultures. Similar antibody-mediated anti-axon effects may be important in some diseases of the human nervous system.
Bourdette
D N
DN
Seil
F J
FJ
Bigbee
J W
JW
DeVries
G H
GH
Garwood
M M
MM
Agrawal
H C
HC
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology*; D001323:Autoantibodies; D001327:Autoimmune Diseases; D001369:Axons / Q000276:immunology*; D046508:Culture Techniques; D005333:Fetus; D005727:Ganglia, Spinal / Q000276:immunology; D051379:Mice; D009422:Nervous System Diseases / Q000209:etiology*; D013116:Spinal Cord / Q000276:immunology
D000954:Antigens, Surface; D001323:Autoantibodies