Tumor growth promoting activity of an immunosuppressive substance and its modulation by protein-bound polysaccharide PSK.
The role of an immunosuppressive substance (IS), which is increased in the serum of tumor-bearing animals, was examined in rats. IS isolated from cancerous ascites fluid of rats was administered to Walker 256 tumor-bearing rats to examine changes in the serum level of IS, tumor growth and survival rate. PSK, an immunomodulator, was also administered. Serum IS increased with tumor growth. The administration of IS to tumor-transplanted rats caused the tumor to grow and shortened the animals' survival time. The administration of PSK, however, inhibited the increase in serum level of IS, resulting in the suppression of tumor growth and a prolongation of survival time. The findings suggested that IS is a useful parameter for predicting not only tumor growth but also the therapeutic effect of immunomodulators such as PSK.
Fujii
M
M
Biomedical Research Laboratories, Kureha Chemical Industry Co., Tokyo, Japan.
Fujii
T
T
Saito
K
K
Takahashi
N
N
Yoshikumi
C
C
Kakuchi
J
J
Kawai
Y
Y
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002279:Carcinoma 256, Walker / Q000276:immunology* / Q000378:metabolism / Q000401:mortality; D006023:Glycoproteins / Q000096:biosynthesis* / Q000097:blood / Q000494:pharmacology; D007122:Immunoelectrophoresis; D008213:Lymphocyte Activation; D008970:Molecular Weight; D009363:Neoplasm Proteins; D011509:Proteoglycans / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000276:Adjuvants, Immunologic; D006023:Glycoproteins; D009363:Neoplasm Proteins; D011509:Proteoglycans; C038588:serum immunosuppressive factor, human; C010770:polysaccharide-K