[Body vitamin A allowance of rats as a factor affecting the metabolism and toxicity of xenobiotics].
In experiments on albino rats it was shown that vitamin A deficiency delays and its excess enhances biotransformation of aminopyrine and benzoic acid. Vitamin A excess exerted the protective effect in acute intoxication with bromobenzene, cyclophosphamide and dimethylnitrosamine.
A A
AA
Pentiuk
V I
VI
Gutsol
N B
NB
Lutsiuk
N G
NG
Bogdanov
D000632:Aminopyrine / Q000493:pharmacokinetics; D000818:Animals; D001565:Benzoates / Q000493:pharmacokinetics; D019817:Benzoic Acid; D001711:Biotransformation; D001969:Bromobenzenes / Q000633:toxicity; D003520:Cyclophosphamide / Q000633:toxicity; D004128:Dimethylnitrosamine / Q000633:toxicity; D004224:Diterpenes; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000084562:Retinyl Esters; D013997:Time Factors; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism*; D014802:Vitamin A Deficiency / Q000378:metabolism
D001565:Benzoates; D001969:Bromobenzenes; D004224:Diterpenes; D000084562:Retinyl Esters; D000632:Aminopyrine; D014801:Vitamin A; C014794:retinol palmitate; D003520:Cyclophosphamide; D019817:Benzoic Acid; C032036:bromobenzene; D004128:Dimethylnitrosamine
Obespechennost' organizma krys vitaminom A kak faktor, vliiaiushchiĭ na metabolizm i toksichnost' ksenobiotikov.