Synthesis of heparin fragments: a methyl alpha-pentaoside with high affinity for antithrombin III.
The synthesis is described of the methyl alpha-glycoside of the pentasaccharide which represents the sequence in heparin responsible for binding and activation of the anticoagulant protein Antithrombin III. It was obtained in a yield much better than that of the previously synthesised pentasaccharide and exhibited the same biological properties.
Institut Choay, Paris, France.
M
M
Petitou
P
P
Duchaussoy
I
I
Lederman
J
J
Choay
J C
JC
Jacquinet
P
P
Sinaÿ
G
G
Torri
D000990:Antithrombin III / Q000378:metabolism*; D006493:Heparin / Q000138:chemical synthesis* / Q000378:metabolism; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000378:metabolism; D009904:Optical Rotation; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D009844:Oligosaccharides; D000990:Antithrombin III; D006493:Heparin