Methylphenidate affects strategic choice behavior in normal adult humans.
The time course of serum concentration and performance on a concurrent probability matching task were evaluated in normal adults receiving 0.15 or 0.3 mg/kg of methylphenidate. The behavioral task, an arcade-like problem-solving game, revealed that drug-treated subjects improved their performance upon repeated testings during pharmacokinetic evaluation at a lower rate than did non-treated controls over the same time span. However, drug-treated subjects failed to adopt the adaptive problem-solving strategies selected by controls.
University of North Carolina, Chapel Hill 27514.
S R
SR
Schroeder
K
K
Mann-Koepke
C T
CT
Gualtieri
D A
DA
Eckerman
G R
GR
Breese
D000293:Adolescent; D000328:Adult; D002755:Choice Behavior / Q000187:drug effects; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000097:blood / Q000494:pharmacology*; D011336:Probability; D011340:Problem Solving / Q000187:drug effects*; D012055:Reinforcement Schedule
D008774:Methylphenidate