Treatment failure in celiac disease due to coexistent exocrine pancreatic insufficiency.
A 17-year-old white adolescent had a history of chronic diarrhea, delayed puberty, and growth failure. Investigations excluded cystic fibrosis, Shwachman syndrome, and endocrine causes of growth failure. Severe steatorrhea was diagnosed from fecal fat studies, and a jejunal suction biopsy showed total villus atrophy, consistent with a diagnosis of celiac disease. Following introduction of a gluten-free diet, his appetite and growth improved, but he continued to have abdominal discomfort and loose offensive bowel motions. One year later, severe steatorrhea was present. A repeat jejunal biopsy showed partial recovery of villus architecture. Serum immuno-reactive trypsinogen level was low, which was highly suggestive of exocrine pancreatic failure. Results of quantitative pancreatic stimulation test confirmed the presence of primary pancreatic insufficiency. After introduction of oral pancreatic enzyme supplements with meals, his gastrointestinal symptoms resolved and growth velocity accelerated. Previously, primary pancreatic insufficiency has only been described in elderly patients with long-standing untreated celiac disease. This case, however, emphasizes that pancreatic failure can occur with celiac disease at any age. Determination of a serum immunoreactive trypsinogen level should be considered a useful screening tool for pancreatic insufficiency in patients with celiac disease who have not responded to a gluten-free diet.
Department of Pediatrics, University of Toronto, Canada.
Z
Z
Weizman
J R
JR
Hamilton
H R
HR
Kopelman
G
G
Cleghorn
P R
PR
Durie
D000293:Adolescent; D002446:Celiac Disease / Q000150:complications* / Q000178:diet therapy; D010188:Exocrine Pancreatic Insufficiency / Q000150:complications* / Q000175:diagnosis; D005983:Glutens; D006130:Growth Disorders / Q000628:therapy; D006801:Humans; D008297:Male; D010186:Pancreatic Function Tests / Q000379:methods; D014362:Trypsinogen / Q000097:blood
D005983:Glutens; D014362:Trypsinogen