Autofluorescence of the lens in diabetic and healthy subjects by fluorophotometry.
Autofluorescence (lambda = 530 nm) of the human lens was determined as a function of age by fluorophotometry in insulin-dependent diabetics and in healthy controls. Statistical analysis revealed a significant linear age dependency for both groups (7.98 ng eq X ml-1 y-1 for diabetic patients, P less than 0.001 and 6.36 ng eq X ml-1 y-1 for healthy controls, P less than 0.001) and a significant dependency on diabetes duration (8.78 ng eq X ml-1 per year of diabetes duration, P less than 0.001). The increase with age was found from about zero value at early childhood.
J C
JC
Bleeker
J A
JA
van Best
L
L
Vrij
E A
EA
van der Velde
J A
JA
Oosterhuis
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis*; D005451:Fluorescein Angiography; D006801:Humans; D007908:Lens, Crystalline / Q000473:pathology*; D008875:Middle Aged