Effect of lomustin on some platelet functions in vitro.
The effect of lomustin on platelet functions was investigated in vitro using a wide battery of tests. Lomustin was found to act as a specific inhibitor of platelet aggregation, release reaction and clot retraction and to induce acquired thrombocytopathy. Thus, impairment of platelet functions might play a role in hemorrhagic complications accompanying lomustin therapy in some cases.
Kubisz
P
P
Division of Clinical Biochemistry and Hematology, General Hospital, Cadca, Czechoslovakia.
Parízek
M
M
Touhami
H
H
Brahimi
S
S
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects*; D003018:Clot Retraction; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D008130:Lomustine / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010977:Platelet Factor 3 / Q000037:antagonists & inhibitors; D010978:Platelet Factor 4 / Q000037:antagonists & inhibitors; D010979:Platelet Function Tests; D012702:Serotonin Antagonists / Q000494:pharmacology
D012702:Serotonin Antagonists; D010977:Platelet Factor 3; D010978:Platelet Factor 4; D000244:Adenosine Diphosphate; D008130:Lomustine; D003094:Collagen; D004837:Epinephrine