Using average lifetime dose rate for intermittent exposures to carcinogens.
The effect of using the average dose rate over a lifetime as a representative measure of exposure to carcinogens is investigated by comparing the true theoretical multistage intermittent-dosing lifetime low-dose excess risk to the theoretical multistage continuous-dosing lifetime risk corresponding to the average lifetime dose rate. It is concluded that low-dose risk estimates based on the average lifetime dose rate may overestimate the true risk by several orders of magnitude, but that they never underestimate the true risk by more than a factor of k/r, where k is the total number of stages in the multistage model and r is the number of stages that are dose-related.
Kodell
R L
RL
Biometry Staff, National Center for Toxicological Research, Jefferson, Arkansas 72079.
Gaylor
D W
DW
Chen
J J
JJ
D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D004781:Environmental Exposure; D006801:Humans; D008954:Models, Biological; D012307:Risk Factors; D013223:Statistics as Topic
D002273:Carcinogens