Effect of Brahmi Rasayan on the central nervous system.
Brahmi Rasayan, an Ayurvedic preparation, was studied in mice and rats for its effects on the central nervous system at oral doses ranging between 1 and 30 g/kg. Observational screening in mice was carried out following a multiparametric check list. The test material was studied for its effect on pentobarbitone hypnosis, motor co-ordination, tail-withdrawal reaction time, electroshock, chemoconvulsions, haloperidol-induced catalepsy and conditioned avoidance response. The test material exhibited a sedative effect and significantly prolonged the hypnotic action of pentobarbitone. It produced a variable blockade of conditioned avoidance response. The presence of a significant antinociceptive effect, coupled with the ability of the test substance to offer protection against electroshock seizures and chemoconvulsions plus the ability to antagonize the haloperidol-induced catalepsy, suggests an involvement of the GABA-ergic system in the mediation of the central nervous system effects of Brahmi Rasayan.
Department of Pharmacology and Experimental Therapeutics, Dr. Sampurnanand Medical College, Jodhpur, Rajasthan, India.
B
B
Shukia
N K
NK
Khanna
J L
JL
Godhwani
D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants; D001362:Avoidance Learning / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced; D002490:Central Nervous System / Q000187:drug effects*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D012890:Sleep / Q000187:drug effects
D000700:Analgesics; D000927:Anticonvulsants; D010936:Plant Extracts; D010424:Pentobarbital; D006220:Haloperidol