Roles of kallikrein-kinin system in acute inflammation: studies on high- and low-molecular weight kininogens-deficient rats (B/N-Katholiek strain).
Carrageenin-induced paw edema in HMW- and LMW-kininogens-deficient rats was significantly less than that in normal rats. There are three kininogens, HMW-, LMW- and T-kininogens, in normal rat plasma, but B/N-Katholiek rat plasma contains only T-kininogen. The pretreatment with captopril, a kiniase II inhibitor, enhanced paw swelling of normal rats, but not that of the deficient rats, indicating that bradykinin released from HMW-kininogen may have a role for the swelling but T-kinin may not be released in this inflammation.
Department of Pharmacology, School of Pharmac. Sci., Kitasato University, Minatoku, Tokyo.
S
S
Oh-ishi
I
I
Hayashi
I
I
Utsunomiya
M
M
Hayashi
K
K
Yamaki
A
A
Yamasu
T
T
Nakano
D000818:Animals; D007249:Inflammation / Q000097:blood* / Q000209:etiology; D007610:Kallikreins / Q000097:blood; D007704:Kininogens / Q000097:blood / Q000172:deficiency*; D007705:Kinins / Q000097:blood; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN
D007704:Kininogens; D007705:Kinins; D007610:Kallikreins