Effect of ethanol on human umbilical artery and vein in vitro.
In vitro effects of ethanol on human umbilical artery and vein were studied. Ethanol (0.5-2.0%) elicited a dose-dependent contractile response both in the umbilical arterial and venous strips in Krebs' and Ca2+-free Krebs' solution. In umbilical artery, but not in vein, ethanol shifted the CaCl2-induced dose-response curves to the right in a parallel manner along with a significant reduction in K+-depolarized maximal tension. These result demonstrate that ethanol can elicit a potent contractile response both in human umbilical arteries and veins and could aid in explaining why ethanol can induce the fetal alcohol syndrome.
Yang
H Y
HY
Shum
A Y
AY
Ng
H T
HT
Chen
C F
CF
D000328:Adult; D002122:Calcium Chloride / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D011247:Pregnancy; D014469:Umbilical Arteries / Q000187:drug effects*; D014471:Umbilical Veins / Q000187:drug effects*
D000431:Ethanol; D002122:Calcium Chloride