Adaptation to cold antagonizes neurotensin-induced hypothermia in mice.
Intracerebrally-administered neurotensin produces a marked hypothermia in a variety of mammals. In this study, prior adaptation to a cold environment was found to significantly antagonize the hypothermia produced by intracisternally-administered neurotensin in mice. This antagonism required both previous exposure to cold ambient temperatures and cold exposure immediately prior to, or simultaneously with, neurotensin administration. The antagonism of neurotensin-induced hypothermia by prior cold-adaptation was blocked by indomethacin, but not by acetylsalicylic acid, suggesting that brain prostaglandin synthesis may be essential for this newly-discovered phenomenon.
Merritt
W D
WD
Bissette
G
G
Luttinger
D
D
Prange
A J
AJ
Nemeroff
C B
CB
D000222:Adaptation, Physiological; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D003080:Cold Temperature; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007267:Injections; D008297:Male; D051379:Mice; D009496:Neurotensin / Q000494:pharmacology*; D011453:Prostaglandins / Q000502:physiology; D013346:Subarachnoid Space; D013961:Thyroid Gland / Q000502:physiology
D011453:Prostaglandins; D009496:Neurotensin