Clofazimine-induced bull's-eye retinopathy.
Bull's-eye retinopathy has multiple associations. We report a case of bull's-eye retinopathy presumed to be secondary to clofazimine (Lamprene) treatment of a 30-year-old patient with acquired immunodeficiency syndrome (AIDS). Pretreatment baseline eye exam of this patient was normal except for bilateral cotton-wool spots. However, follow-up exam 5 months later revealed bilateral anterior pigmentary corneal deposits in a whorl pattern, a presumed infectious retinitis in the left eye, and bilateral annular macular pigmentary abnormalities. The patient was taken off clofazimine treatment, but died 1 month later. The authors suggest that patients being treated with clofazimine be examined for drug-related corneal and retinal lesions.
Craythorn
J M
JM
Swartz
M
M
Creel
D J
DJ
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D002991:Clofazimine / Q000009:adverse effects* / Q000627:therapeutic use; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008266:Macula Lutea / Q000473:pathology; D008297:Male; D009164:Mycobacterium Infections / Q000150:complications / Q000188:drug therapy; D010859:Pigmentation Disorders / Q000139:chemically induced; D012174:Retinitis Pigmentosa / Q000139:chemically induced* / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced
D002991:Clofazimine