[EEG studies in rats to determine the threshold levels of chlorpromazine with respect to the state of vigilance].
Taking into account the actual vigilance status of the animals (awake, drowsiness, slow-wave-sleep) we were able to show EEG changes at lower chlorpromazine levels (0.42 mumole/kg b.w., i.p.) in contrast to 1.4 mumole/kg b.w., i.p.) in the model "without considering the vigilance status". These changes were especially pronounced during the awake state.
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D000818:Animals; D001921:Brain / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology*; D004569:Electroencephalography; D008297:Male; D051381:Rats; D014851:Wakefulness / Q000187:drug effects*
D002746:Chlorpromazine
EEG-Untersuchungen an Ratten zur Bestimmung der Schwellendosis von Chlorpromazin unter Berücksichtigung des Vigilanzzustandes.