Quantification of ethylene chlorohydrin and ethylene glycol as potential reaction products in gas-sterilized medical-grade plastics.
A gas chromatographic procedure is described for the quantitative determinations of ethylene chlorohydrin and ethylene glycol in disposable medical-grade plastics. Both components are isolated by solvent extraction. The lower limit of detection is 1 p.p.m. of ethylene chlorohydrin and 2 p.p.m. of ethylene glycol. Propylene glycol is used as an internal standard. Ethylene oxide residues have to be removed prior to the assay.
De Rudder
D
D
De Graeve
E
E
Van Severen
R
R
Braeckman
P
P
D055598:Chemical Phenomena; D002621:Chemistry; D002728:Chlorohydrins / Q000032:analysis*; D002849:Chromatography, Gas; D004209:Disposable Equipment; D005023:Ethylene Chlorohydrin / Q000032:analysis*; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000032:analysis*; D005027:Ethylene Oxide; D005740:Gases; D010969:Plastics; D013242:Sterilization
D002728:Chlorohydrins; D005026:Ethylene Glycols; D005740:Gases; D010969:Plastics; D005023:Ethylene Chlorohydrin; D019855:Ethylene Glycol; D005027:Ethylene Oxide