Increased number of hypothalamic [3H] (+)-amphetamine binding sites in genetically obese (ob/ob) mice.
In genetically obese (ob/ob) mice the development of obesity was correlated with the binding of [3H] (+)-amphetamine to the hypothalamus. In 39-day-old ob/ob mice, which had obtained a body weight greater than 150% of their lean littermates, hypothalamic [3H] (+)-amphetamine binding had increased by approximately 60% above levels of their lean littermates. This increased number of hypothalamic [3H] (+)-amphetamine binding sites appeared during the onset of obesity and then remained elevated following the most prominent weight gain. Since ob/ob mice are markedly hyperglycemic throughout their life, the increase in [3H] (+)-amphetamine binding site density in the hypothalamus may be secondary to elevated blood glucose.
Hauger
R
R
Hulihan-Giblin
B
B
Paul
S M
SM
D000375:Aging; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002352:Carrier Proteins; D003913:Dextroamphetamine / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D011941:Receptors, Adrenergic / Q000378:metabolism*
D001786:Blood Glucose; D002352:Carrier Proteins; D011941:Receptors, Adrenergic; C036062:amphetamine receptor; D003913:Dextroamphetamine