[Sulfhydryl maintenance treatment in rheumatoid polyarthritis. A series of 120 cases followed for 10 years and a study of possibilities of changing the drug].
The authors present a series of 120 cases of sero-positive rheumatoid arthritis followed for ten years and treated with D-penicillamine, gold salts and pyrithioxine used either alone or sequentially after stopping one of these treatments because of failure, intolerance or escape. This series can be broken down as follows: 13% of patients are under treatment after ten years, 27% had a favourable result with one of the three treatments for five to ten years, 59% had a poor result (less than 5 years) or no effect. However, it appeared that a failure or an escape from one of these products did not signify a failure with another product and side effects did not necessarily recur with a change of treatment.
J P
JP
Camus
A C
AC
Koeger
P
P
Struz
C
C
Laveant
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006046:Gold / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D011746:Pyrithioxin / Q000627:therapeutic use*; D013997:Time Factors
D011725:Pyridines; D006046:Gold; D011746:Pyrithioxin; D010396:Penicillamine
Traitements de fond sulfhydrylés au cours de la polyarthrite rhumatoïde. Une série de 120 cas suivis pendant dix ans avec étude des possibilités de changement de médicament.