The concentration in brain of octopamine and tyramine after portal-systemic bypass in rats: neuroamine concentrations determined simultaneously by methane chemical ionization gas chromatography mass spectrometry.
The concentration in brain of both octopamine (OCT) and tyramine (TYR) was significantly increased in rats 8 weeks after portal-systemic bypass. This suggests that the increase in OCT is secondary to increased decarboxylation of tyrosine to TYR. However, the role these neuroamines, particularly OCT, play in the development of hepatic encephalopathy remains controversial.
Meredith
C G
CG
Duffield
P H
PH
Dougan
D F
DF
Duffield
A M
AM
Wade
D N
DN
D015078:2-Hydroxyphenethylamine / Q000031:analogs & derivatives / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D001921:Brain / Q000378:metabolism*; D003903:Deuterium; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D009655:Octopamine / Q000031:analogs & derivatives*; D009929:Organ Size; D010627:Phenethylamines / Q000378:metabolism*; D011168:Portal System / Q000601:surgery*; D011169:Portal Vein / Q000601:surgery*; D051381:Rats; D011919:Rats, Inbred Strains; D014439:Tyramine / Q000378:metabolism*
D010627:Phenethylamines; D009655:Octopamine; D015078:2-Hydroxyphenethylamine; D003903:Deuterium; C005310:norfenefrine; D014439:Tyramine