Anticonvulsant activity of two polyethylene glycols in mice.
The anticonvulsant activity of two polyethylene glycols of different molecular weight (400 and 4000) was tested in mice. The two substances were inactive in the maximal electroshock test, but, when intraperitoneally administered, were efficacious in the pentetrazole and strychnine seizure tests. Polyethylene glycol 4000 showed the most potent anticonvulsant action. On the contrary, when polyethylene glycols were orally administered, they did not alter the time for seizure onset and for death.
Bartoli Klugmann
F
F
Decorti
G
G
Candussio
L
L
Baldini
L
L
D000818:Animals; D000927:Anticonvulsants; D004597:Electroshock; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011092:Polyethylene Glycols / Q000494:pharmacology* / Q000633:toxicity; D013331:Strychnine / Q000037:antagonists & inhibitors
D000927:Anticonvulsants; D011092:Polyethylene Glycols; D013331:Strychnine; D010433:Pentylenetetrazole