Effects of compound D600 (methoxyverapamil) on drug-induced contractions of isolated dog uterine muscle.
The contractile responses of the isolated dog uterus to acetylcholine (Ach), oxytocin (Ot), histamine (Hist) and barium chloride (Ba2+) were non-competitively blocked by compound D600. This compound was significantly more potent against Ba2+-induced contractions. Increasing the calcium (Ca2+) concentration from 0.2 to 2.5 mM reverted the inhibitory effects of D600 against Ach, Ot, Hist and 1 mM Ba2+. The blockade produced by D600 against 30 mM Ba2+ was not reversed by increasing the Ca2+ concentration. In high K+-depolarizing solution, D600 produced a parallel and concentration-dependent displacement to the right to the concentration-response curves of both Ca2+ and Ba2+. The Schild plot yielded similar pA2 values for D600 against Ca2+ and Ba2+.
Calixto
J B
JB
Antônio
A
A
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001464:Barium / Q000494:pharmacology; D002122:Calcium Chloride / Q000494:pharmacology; D004285:Dogs; D005260:Female; D005711:Gallopamil / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D010121:Oxytocin / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
D001464:Barium; D005711:Gallopamil; D010121:Oxytocin; D006632:Histamine; D014700:Verapamil; D002122:Calcium Chloride; D000109:Acetylcholine