Conditioning the placebo response in the rotational model of Parkinson's disease.
Persistent behavioural effect of the direct dopamine receptors agonist apomorphine in the rotational model of Parkinson's disease was investigated. We show how this placebo response can be considered an extraordinary example of environment-drug associative learning and how it can be related to a critical point of the time-course response to the drug after repeated administration. Classical conditioning of "placebo response" in an animal model of a neurological or psychiatric disease had not been reported previously.
Department of Psychobiology, School of Psychology, University of La Laguna, Tenerife, Canary Islands, Spain.
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E
Burunat
M D
MD
Diaz Palarea
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R
Castro
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M
Rodriguez
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage* / Q000494:pharmacology; D004195:Disease Models, Animal; D008297:Male; D010302:Parkinson Disease, Secondary / Q000503:physiopathology*; D010919:Placebos; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects*
D010919:Placebos; D011954:Receptors, Dopamine; D001058:Apomorphine