[Relation between the hypotensive effect of triampur and its pharmacokinetics in patients with hypertension].
The hypotensive effect of triampur was studied in 39 patients with first- and second-stage essential hypertension, as was the pharmacokinetics of triamterin, the main constituent of triampur. A relationship is demonstrated between the curve area, blood triamterin peak, clearance and cumulative excretion, on the one hand, and the hypotensive effect, on the other. Triamterin pharmacokinetic studies may be used for the screening of hypertensive patients as potential candidates for triampur treatment. Alongside other causes, low blood concentrations of the drug in the course of treatment may be associated with its low efficiency.
Kuznetsov
G P
GP
Lebedev
P A
PA
D000293:Adolescent; D000328:Adult; D000959:Antihypertensive Agents / Q000378:metabolism / Q000627:therapeutic use*; D004338:Drug Combinations / Q000378:metabolism / Q000627:therapeutic use; D005260:Female; D006207:Half-Life; D006801:Humans; D006852:Hydrochlorothiazide / Q000378:metabolism / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D013607:Tablets; D014223:Triamterene / Q000378:metabolism / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D004338:Drug Combinations; D013607:Tablets; D006852:Hydrochlorothiazide; C020743:hydrochlorothiazide-triamterene; D014223:Triamterene
Zavisimost' gipotenzivnogo effekta triampura ot ego farmakokinetiki u bol'nykh gipertonicheskoĭ bolezn'iu.