Acute amoxicillin nephrotoxicity following an overdose.
A 3 year old boy developed acute renal failure following an ingestion of 574 mg/kg of amoxicillin. Accidental ingestions of oral penicillins occur commonly, and are usually considered completely nontoxic. Based on this case, however, the possibility of adverse effects following large oral doses of penicillin-type antibiotics, mediated by allergic hypersensitivity or direct toxicity, should be considered.
Geller
R J
RJ
Chevalier
R L
RL
Spyker
D A
DA
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000658:Amoxicillin / Q000097:blood / Q000506:poisoning*; D002675:Child, Preschool; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D013997:Time Factors
D000658:Amoxicillin