Endotoxicity associated with the Lyme disease Borrelia: recent findings.
The endotoxicity of Borrelia burgdorferi, the causative agent of Lyme Disease, a tick-borne spirochetosis, was studied using Limulus assay and pyrogen test in rabbit. Some suspensions of Ixodes ricinus and Ixodes dammini associated Borrelia were able to gelify Limulus lysate and demonstrated a febrile response in rabbit. These findings and other recent data demonstrating an endotoxin-like activity of the Lyme Disease agent are discussed in the context of the pathogenic mechanisms of the illness.
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D
Fumarola
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I
Munno
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C
Marcuccio
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G
Miragliotta
D000818:Animals; D001898:Borrelia / Q000472:pathogenicity; D004731:Endotoxins / Q000032:analysis*; D006801:Humans; D008033:Limulus Test; D008193:Lyme Disease / Q000382:microbiology*; D011749:Pyrogens; D011817:Rabbits; D013987:Ticks / Q000382:microbiology
D004731:Endotoxins; D011749:Pyrogens