Bovine, porcine and ovine picornaviruses: identification of viruses with properties similar to human coxsackieviruses.
Eleven bovine, 19 porcine, and 3 ovine picornaviruses were tested for their ability to grow in the presence of the viral inhibitors 2-(alpha-hydroxy-benzyl)- benzimidazole (HBB) and guanidine-HC1 (GHC1). The nature of the lesions produced by inoculation of newborn mice with these viruses was also investigated. Nine bovine viruses were inhibited by both compounds, and produced skeletal myonecrosis in mice, suggesting similarities to the human coxsackie group B viruses and indicating potential pathogenicity for bovine species. One bovine virus (VH7) was inhibited by GHC1 but not by HBB and caused widespread skeletal muscle damage in mice typical of coxsackie group A viruses. Another bovine virus (F266a) was inhibited only by HBB. None of the porcine or ovine viruses showed significant inhibition by either compound nor produced lesions in mice.
Veterinary Research Laboratories, Stormont, Belfast, U.K.
B M
BM
Adair
S
S
Kennedy
E R
ER
McKillop
M S
MS
McNulty
J B
JB
McFerran
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology; D002417:Cattle / Q000382:microbiology*; D006146:Guanidines / Q000494:pharmacology; D010849:Picornaviridae; D012756:Sheep / Q000382:microbiology*; D013552:Swine / Q000382:microbiology*; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D001562:Benzimidazoles; D006146:Guanidines; C020359:2-hydroxybenzylbenzimidazole