Malignant epithelioid peripheral nerve sheath tumor arising in a benign schwannoma.
The case of a patient with malignant degeneration of a solitary abdominal schwannoma and endobronchial metastasis is presented. The patient presented clinically with dyspnea referable to her lung mass, anorexia, and night sweats. The lung mass, initially diagnosed as a large-cell undifferentiated carcinoma, was later found to be histologically identical to the malignant portion of the abdominal tumor. The light microscopic, electron microscopic, and immunoperoxidase staining characteristics of the tumor are reported, and previous reports in the literature are reviewed.
Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21205.
S S
SS
Robey
S H
SH
deMent
K K
KK
Eaton
H
H
Aoun
D000008:Abdominal Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D002277:Carcinoma / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009442:Neurilemmoma / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D010524:Peripheral Nervous System Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure