Organon OD 14 (tibolone) and menopausal dynamic hormone profiles.
Hormonal profiles were studied in 15 post-menopausal women, 7 of whom had been treated with Organon OD 14 (Tibolone) and 8 with placebo tablets for 3 yr. In the Tibolone-treated group, the sex hormone binding globulin (SHBG) levels were significantly lower, while the estimated free testosterone levels, the testosterone/SHBG ratio and the thyroid-stimulating hormone (TSH) response to thyrotrophin-releasing hormone (TRH) were significantly higher than in the placebo group. Prolactin and triiodothyronine (T3) concentrations were lower in the actively treated group, although the differences were not statistically significant. No significant differences were observed with respect to thyroxine (T4), TSH, basal cortisol or cortisol response to synacthen.
Abdalla
H I
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Hart
D M
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Lindsay
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Beastall
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D045930:Anabolic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008593:Menopause; D009652:Norpregnenes / Q000627:therapeutic use*; D010907:Pituitary Hormones / Q000097:blood; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood / Q000378:metabolism
D045930:Anabolic Agents; D009652:Norpregnenes; D010907:Pituitary Hormones; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; C027385:tibolone