Mechanisms of injury in unilateral testis torsion.
We investigated the mechanisms of injury involved in unilateral testis torsion as well as the interventional effects of orchiectomy at 48 h and immunosuppression with corticosteroids in rats. Torsion was associated with abnormal contralateral testis histology and raised antilymphocytes and antisperm antibody titers. Both orchiectomy and steroid administration lessened these findings, suggesting that an immunological process underlies the abnormality seen in this experiment model.
Kogan
S
S
Owens
G
G
Tarter
T
T
Nehlsen-Cannarella
S
S
Bennett
B
B
Gill
B
B
Levitt
S
S
D000818:Animals; D000961:Antilymphocyte Serum / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D009919:Orchiectomy; D011241:Prednisone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013086:Spermatic Cord Torsion / Q000097:blood / Q000473:pathology*; D013094:Spermatozoa / Q000276:immunology
D000961:Antilymphocyte Serum; D007074:Immunoglobulin G; D011241:Prednisone