Potential antitumor agents. II. Lappin intramolecular cyclization of diethyl 3-carbazolylaminomethylenemalonate: a structure assignment.
Diethyl 3-carbazolylaminomethylenemalonate undergoes Lappin cyclization giving 2-carbethoxy-1-oxo-1,4-dihydro-7H-pyrido[2,3-c]carbazole. Formation of an angular pyridocarbazole derivative is consistent with the Markwald rule. The synthesis of 4-ethyl derivatives of the above pyridocarbazole and its 8,9,10,11-tetrahydro derivative is also reported as a goal to potential indoloquinolone antitumoral agents.
Istituto di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia, Università degli Studi di Roma, La Sapienza, Italy.
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F
Corelli
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Massa
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Stefancich
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Artico
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Silvestri
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D008314:Malonates / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D002227:Carbazoles; D008314:Malonates