Genotype-controlled changes in body composition and fat morphology following overfeeding in twins.
This study investigated the effects of overfeeding on the body composition and fat morphology characteristics of 6 pairs of male monozygotic twins. Each participant was submitted to a 22-day overfeeding period, supplemented by an additional 1000 kcal/day. Significant changes were observed in body composition and fat morphology as shown by increases in body weight, fat mass, sum of 9 skinfolds, and fat cell diameter. Significant within-pair resemblance for absolute changes was observed for body weight, percent body fat, fat mass, sum of skinfolds, trunk skinfolds, and extremity skinfolds, suggesting a role for the genotype in determining the sensitivity of the response to an energy surplus. Significant within-pair resemblance was noted for the biceps, triceps, and thigh with less resemblance noted in the subscapular, abdomen, suprailiac, calf, axillary, and chest sites, suggesting a variation in genotype dependency for subcutaneous fat. The results suggest that changes in body fat following short-term overfeeding appear to have a genetic basis.
E T
ET
Poehlman
A
A
Tremblay
J P
JP
Després
E
E
Fontaine
L
L
Pérusse
G
G
Thériault
C
C
Bouchard
D000273:Adipose Tissue / Q000033:anatomy & histology*; D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001823:Body Composition; D004041:Dietary Fats / Q000008:administration & dosage; D002149:Energy Intake; D005838:Genotype; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics; D012885:Skinfold Thickness; D014427:Twins; D014430:Twins, Monozygotic
D004041:Dietary Fats