Quantitative motor assessment in amyotrophic lateral sclerosis.
Reliable measurements are needed to document the natural history of ALS and to determine therapeutic efficacy. We have devised a standardized protocol that generates interval data sensitive to change-the Tufts Quantitative Neuromuscular Exam (TQNE). The TQNE consists of the following four major categories: pulmonary function, oropharyngeal function, timed functional activities, and isometric strength using an electronic strain gauge. The 29-item exam takes about 1 hour to administer and has excellent test-retest reliability.
P L
PL
Andres
W
W
Hedlund
L
L
Finison
T
T
Conlon
M
M
Felmus
T L
TL
Munsat
D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007537:Isometric Contraction; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D009046:Motor Neurons / Q000502:physiology; D009119:Muscle Contraction; D009132:Muscles / Q000503:physiopathology; D009960:Oropharynx / Q000503:physiopathology*