Glucose and erythrocyte ATP: distinctive effects of dipyridamole and of ticlopidine.
This experiment suggests the following points: 1. Erythrocytes in control patients and in atherosclerosis patients seem to have a variable grade of affinity for adenosine and for plasma glucose. This variable grade seems to fix the level of the adenosine triphosphate (ATP) reserves and induces the erythrocytes' deformability. 2. The drop in the level of ATP reserves that induces the poor deformability of the erythrocytes in atherosclerosis patients would appear to be caused by two consecutive shortages: first a shortage that seems to be related to a deficiency of erythrocyte adenosine as the ATP shortage disappears with dipyridamole treatment and then a shortage induced by the lack of erythrocyte glucose and suppressed by the addition of ticlopidine to the dipyridamole treatment.
Department of Physiology, U.L.B., Free University of Brussels, Belgium.
H
H
Solvay
M
M
Kahn
S
S
Garreyn
M
M
Cloarec
R
R
Sneppe
E
E
Schram
J V
JV
Fenollar
D000241:Adenosine / Q000097:blood / Q000172:deficiency; D000255:Adenosine Triphosphate / Q000097:blood*; D001161:Arteriosclerosis / Q000097:blood; D001786:Blood Glucose / Q000097:blood*; D004176:Dipyridamole / Q000008:administration & dosage / Q000494:pharmacology; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D013988:Ticlopidine / Q000008:administration & dosage
D001786:Blood Glucose; D004176:Dipyridamole; D000255:Adenosine Triphosphate; D000241:Adenosine; D013988:Ticlopidine