The psychomotor effects of single and repeated doses of hypnotic benzodiazepines.
Benzodiazepine hypnotics are used for short periods in low doses in healthy people when stressed and in patients with insomnia. This study examined psychomotor impairment in healthy young males and females after 1 and 7 nights of flunitrazepam (1 mg), nitrazepam (2.5 mg) and temazepam (10 mg). There were substantial inter-individual variations. Results showed that no drug significantly affected psychomotor performance at these doses after single or repeated administration. The number and severity of side-effects were significantly greater after the first night with temazepam and 7 nights with nitrazepam, although this may reflect a statistical artefact rather than a significant clinical finding. The difficulties in performing adequately controlled psychopharmacological studies at low doses are highlighted. Given the large intra- and inter-subject variances, small drug effects would necessitate large sample sizes (21 to 600 subjects at the 95% level of chance of detection) depending on the variable. The study suggests there is minimal impairment with low dose hypnotic drugs and a need to individualize treatment.
Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Australia.
R O
RO
Stanley
J W
JW
Tiller
J
J
Adrian
D000328:Adult; D001569:Benzodiazepines / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D005445:Flunitrazepam / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D008297:Male; D009567:Nitrazepam / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D011596:Psychomotor Disorders / Q000139:chemically induced; D011597:Psychomotor Performance / Q000187:drug effects*; D013693:Temazepam / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology
D001569:Benzodiazepines; D005445:Flunitrazepam; D009567:Nitrazepam; D013693:Temazepam