Recovery of the visual evoked response in the cat following administration of diisopropylfluorophosphate, an irreversible cholinesterase inhibitor.
Visual evoked responses (VER) to counterphased gratings were recorded from area 17 of cat visual cortex prior to and following administration of diisopropylfluorophosphate (DFP). The VER and acetylcholinesterase (AChE) activity of blood, retina, and visual cortex were reduced significantly following DFP administration. Approximately two hours after exposure to 4 mg/kg DFP, the VER began to recover and in some cats returned to base line levels. In contrast, blood, retina, and cortex AChE activity showed little, if any, tendency for recovery throughout the experiment. Since atropine sulfate provided at least partial recovery of the VER following DFP without affecting AChE inhibition, an accumulation of acetylcholine (ACh) probably is involved in the initial visual loss. However, recovery of the VER over time while AChE remained severely inhibited implicates mechanisms other than, or in addition to, accumulation of ACh at receptor sites.
U.S. Army Aeromedical Research Laboratory, Fort Rucker, Alabama 36362-5292.
A W
AW
Kirby
T H
TH
Harding
R W
RW
Wiley
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002415:Cats; D002540:Cerebral Cortex / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D007531:Isoflurophate / Q000494:pharmacology*; D010775:Photic Stimulation; D012160:Retina / Q000201:enzymology; D013997:Time Factors
D002800:Cholinesterase Inhibitors; D007531:Isoflurophate; D001285:Atropine; D000110:Acetylcholinesterase