Motor endplate involvement in the extraocular muscles of the myotonic rat.
The motor endplates from the extraocular muscles of rats administered 20,25-diazacholesterol were examined by electron microscopy. Many anomalies were found at various levels of the junctional complex. Electron microscopy showed disrupted sole-plate nuclei, disruptions of the junctional sarcoplasm, atypical sarcoplasmic extensions, simplified postsynaptic areas, and interposition of Schwann cell cytoplasm between axonal terminal and muscle fiber with a reduplication of basement membrane, as well as atrophic and disrupted axonal terminals. These data indicate that the motor endplate is affected as well as the muscle fiber in myotonic dystrophy.
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Pachter
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Eberstein
D000818:Animals; D005123:Eye / Q000473:pathology*; D008297:Male; D009045:Motor Endplate / Q000648:ultrastructure*; D009132:Muscles / Q000473:pathology; D009223:Myotonic Dystrophy / Q000473:pathology*; D009469:Neuromuscular Junction / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains