Stewart-Treves syndrome: an histogenetic (ultrastructural and immunohistological) study.
One case of the so-called "Stewart-Treves syndrome" (STS), appearing on a lymphoedematous arm complicating radical mastectomy for breast cancer, was characterized electronmicroscopically and immunohistologically, in order to elucidate its disputed (epithelial vs endothelial) histogenesis. Epithelial and endothelial differentiation markers used comprised: antibodies against keratin, vimentin, factor VIII-related antigen (F VIII-RA), HLA-DR antigens and the lectin Ulex europeaus agglutinin I (UEA I). At the ultrastructural level, neoplastic cells were found to contain typical Weibel-Palade bodies, whereas by immunohistological techniques they proved to be keratin-negative/vimentin+, F VIII-RA+, UEAI+, HLA-DR+. These results rule out a possible epithelial differentiation and strongly favour an endothelial one for STS.
Kanitakis
J
J
Bendelac
A
A
Marchand
C
C
Rigot-Muller
G
G
Thivolet
J
J
D000368:Aged; D000912:Antibodies, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D008204:Lymphangiosarcoma / Q000276:immunology / Q000648:ultrastructure*; D008408:Mastectomy / Q000009:adverse effects*; D008854:Microscopy, Electron; D012878:Skin Neoplasms / Q000276:immunology / Q000648:ultrastructure*; D013577:Syndrome
D000912:Antibodies, Neoplasm