[Toxic effects of cisplatin in the treatment of malignant bone and soft tissue tumors].
A total of 31 patients with malignant bone and soft tissue tumors were evaluated for toxic effects after receiving cisplatin (104 courses) at doses of 2.0-3.0 mg/kg with aggressive hydration. Nausea was common and in 86% of cisplatin courses severe vomiting was observed. Nephrotoxicity was observed in less than 10% of all courses but ototoxicity, especially tinnitis, developed in 5 of 6 patients whose total doses of cisplatin were over 500mg, and one of them showed hearing disorder in the upper frequency above 5,000 Hz. There were no other toxic effects such as severe myelosuppression, allergic reaction or peripheral neuropathy.
T
T
Umeda
N
N
Takada
E
E
Hodaka
F
F
Endoh
T
T
Ishii
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000188:drug therapy*; D002945:Cisplatin / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D006311:Hearing Disorders / Q000139:chemically induced; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D012983:Soft Tissue Neoplasms / Q000188:drug therapy*; D014012:Tinnitus / Q000139:chemically induced; D014839:Vomiting / Q000139:chemically induced
D002945:Cisplatin