Enhanced radioinduced cytotoxicity of cultured human bladder cancer cells using 43 degrees C hyperthermia or anticancer drugs.
Using a colony-forming technique and 2 human bladder cancer cell lines, T24 and KK-47, the enhanced radioinduced cytotoxicity in combination with 43 degrees C hyperthermia (HPT) or 4 anticancer drugs; bleomycin (BLM), cis-dichlorodiammineplatinum (II) (CDDP), mitomycin C (MMC), carbazilquinone (CQ), has been studied. In the series of both cell lines, the combination of 43 degrees C hyperthermia and irradiation resulted in exceedingly enhanced cytotoxicity. This was characterized by a marked decline of the slope of the radiation dose-survival curve as compared with slope in the combination of each of the anticancer drugs and irradiation. Among the 4 anticancer drugs, BLM was thought to be the most promising agent as a potentiator of the radiotherapy, on the basis of a remarkable decrease in the shoulder portion of the radiation dose-survival curve. The other 3 anticancer drugs showed a certain degree of potentiation of radiosensitivity.
Nakajima
K
K
Department of Urology, School of Medicine, Kanazawa University, Japan.
Hisazumi
H
H
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000628:therapy; D002460:Cell Line; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D006979:Hyperthermia, Induced; D014407:Tumor Cells, Cultured / Q000187:drug effects; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*
D000970:Antineoplastic Agents