Preparation and biological activity of 5,6-dihydro-5-azapyrimidine nucleosides.
The reaction of 5-azapyrimidine nucleosides Ia-IXa with zinc powder in acetic acid afforded the respective 5,6-dihydro derivatives Ib-IXb in high yields. This procedure represents a convenient and general method for preparation of the title compounds. The effects of some dihydro-5-azapyrimidine nucleosides on the growth in vitro of L1210 mouse leukemic cells were estimated.
Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Praha.
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A
Pískala
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B
Cesneková
J
J
Veselý
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011684:Purine Nucleosides