Experimental model for pharmacokinetic studies during continuous peritoneal dialysis in the rabbit.
An experimental model permitting continuous peritoneal dialysis in rabbits, very close to continuous ambulatory peritoneal dialysis (CAPD) as performed in humans, is described. Animals were carefully monitored before and during dialysis for plasma, urine, and dialysate biochemical parameters, and electrocardiogram, body temperature, weight, and white cell count in dialysate. Dialysis was performed successfully for 21 days without failure. Difficulties in setting up the final model are reported. The suitability of the model for pharmacokinetic and pharmacodynamic studies was borne out by administering atenolol (i.v. before CADP, i.v. after one week of CAPD, and i.p. one week later) and analyzing the findings.
G L
GL
Traina
A
A
Celardo
M
M
Arboix
M
M
Bonati
D000818:Animals; D001262:Atenolol / Q000378:metabolism; D002404:Catheterization; D004562:Electrocardiography; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D010531:Peritoneal Dialysis, Continuous Ambulatory; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D011817:Rabbits
D004364:Pharmaceutical Preparations; D011506:Proteins; D001262:Atenolol