[Experience with objective evaluation of the action of cimetidine--a blocker of histamine-H2 receptors--in patients with peptic ulcer of the duodenum].
The action of cimetidine, a blocker of H2-histamine receptors, is analysed as compared with the peripheral M-cholinolytics atropine and chlorosyl when administered in single doses and in courses. Study of the drug action on the basic functions of the stomach and on the clinical course of the disease was performed with the aid of the original research methods, mathematic analysis of the pH-grams and electrogastrograms. It was revealed that cimetidine compared very favourably with the peripheral M-cholinolytics as regards the action on acid formation in the stomach, particularly if the drug was applied in single doses, and on the clinical course of the disease, primarily in reference to ulcer cicatrization. However, cimetidine appeared inferior to the cholinolytics in the potency of the inhibitory action on motor function of the stomach both when given in a single dose and in courses.
Tsimmerman
Ia S
IaS
Syman
L N
LN
Golovanova
E S
ES
D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001285:Atropine / Q000627:therapeutic use; D002794:Choline / Q000031:analogs & derivatives*; D002927:Cimetidine / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D005769:Gastrointestinal Motility; D006801:Humans; D010276:Parasympatholytics / Q000627:therapeutic use; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use; D012008:Recurrence
D000897:Anti-Ulcer Agents; D010276:Parasympatholytics; D000644:Quaternary Ammonium Compounds; C053909:chlorozil; D001285:Atropine; D002927:Cimetidine; D002794:Choline
Opyt ob"ektivnoĭ otsenki deĭstviia tsimetidina--blokatora H2-retseptorov gistamina--u bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki.