[Mechanism of action of piracetam on NADH oxidation via the external pathway in rat liver mitochondria].
Activation of the external pathway (amytalantimycine A-resistant) of the exogenous NADH oxidation was studied in rat liver mitochondria after long-term (within 6 days) administration of pyracetame. Stimulation of lipid peroxidation and a decrease in viscosity of mitochondrial membranes accompanied the increase in the rate of oxygen consumption in mitochondria in presence of the exogenous NADH, amytal and antimycine A.
A P
AP
Agureev
I V
IV
Zhigacheva
D000818:Animals; D005260:Female; D005456:Fluorescent Dyes; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism*; D008933:Mitochondrial Swelling / Q000187:drug effects; D009243:NAD / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats
D005456:Fluorescent Dyes; D008054:Lipid Peroxides; D011760:Pyrrolidinones; D009243:NAD; D008315:Malondialdehyde; D010889:Piracetam
K mekhanizmu deĭstviia piratsetama na okislenie NADH po vneshnemu puti v mitokhondriiakh pecheni krys.