Effect of chronic administration of doxorubicin on cardiac adenylate cyclase activity in mice.
Cardiac adenylate cyclase activity was examined in mice treated chronically with doxorubicin. Mice received a subcutaneous dose of either 2 or 4 mg/kg doxorubicin twice weekly for 5 weeks. Mice were sacrificed five weeks after the last injection. Basal cardiac adenylate cyclase activity was significantly elevated in both the 2 and 4 mg/kg DXR-treated groups over the control level. GTP, isoproterenol (plus GTP), NaF, and forskolin stimulated activities in both the 2 and 4 mg/kg DXR-treated groups were also significantly elevated over control levels.
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D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D005576:Colforsin / Q000494:pharmacology; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology*; D006160:Guanosine Triphosphate / Q000494:pharmacology; D006321:Heart / Q000033:anatomy & histology / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D051379:Mice; D009206:Myocardium / Q000201:enzymology*; D009929:Organ Size / Q000187:drug effects; D012969:Sodium Fluoride / Q000494:pharmacology
D005576:Colforsin; D004317:Doxorubicin; D006160:Guanosine Triphosphate; D012969:Sodium Fluoride; D000262:Adenylyl Cyclases; D007545:Isoproterenol