Toxic epidermal necrolysis with extensive mucosal erosions of the gastrointestinal and respiratory tracts.
Toxic epidermal necrolysis with epidermal shedding over almost the entire body occurred in a patient with classical rheumatoid arthritis treated with sulindac, penicillamine and a combination analgesic containing paracetamol and chlormezanone. Erosions in the lower respiratory tract and the intestine contributed to a lethal outcome of the disease and showed a microscopical picture similar to that of the skin involved. The histopathological picture of these extracutaneous lesions have been only briefly reported previously.
Roupe
G
G
Ahlmén
M
M
Fagerberg
B
B
Suurküla
M
M
D000082:Acetaminophen / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy; D001706:Biopsy; D002720:Chlormezanone / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007420:Intestine, Large / Q000473:pathology*; D008875:Middle Aged; D010396:Penicillamine / Q000627:therapeutic use; D012137:Respiratory System / Q000473:pathology*; D012867:Skin / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000209:etiology / Q000473:pathology; D013467:Sulindac / Q000627:therapeutic use
D004338:Drug Combinations; D013467:Sulindac; D000082:Acetaminophen; D010396:Penicillamine; D002720:Chlormezanone