Effect of acute lead intoxication on the ultrastructure of rat erythroblasts and reticulocytes. Morphometric analysis and röntgen micro-analysis.
Effect of 17 hr intoxication of lead on the different maturation stages of erythroid cells were studied in rat. Morphometric methods were used to analyse the lead-induced ultrastructural changes in the early, intermediate, late erythroblasts and reticulocytes. It was found that the toxic effect of lead increases with maturation. Energy-dispersive Röntgen micro-analysis showed that fibrillar structures within vesicles and endoplasmic reticulum contained lead.
Heynen
M J
MJ
Department of Medical Research, University of Leuven, Belgium.
Zaman
Z
Z
Verwilghen
R L
RL
D000208:Acute Disease; D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D004577:Electron Probe Microanalysis; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D004900:Erythroblasts / Q000648:ultrastructure*; D007855:Lead Poisoning / Q000473:pathology*; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure; D010588:Phagosomes / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012156:Reticulocytes / Q000648:ultrastructure*; D012270:Ribosomes / Q000648:ultrastructure