Multiple myeloma plasma cell kinetics: rapid and reliable evaluation using 5-bromo-2-deoxyuridine (BrdUrd) DNA incorporation detected by an anti-BrdUrd monoclonal antibody.
In 19 patients with monoclonal gammopathy, plasma cell proliferative activity was evaluated using 5-bromo-2-deoxyuridine (BrdUrd) incorporation, as revealed by an anti-BrdUrd monoclonal antibody. A simultaneous standard labelled thymidine incorporation was carried out in all patients as reference test. The BrdUrd method was confirmed as a reliable test and is recommended for routine clinical application in monoclonal gammopathies.
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M
Boccadoro
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V
Redoglio
P
P
Gavarotti
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A
Pileri
D000911:Antibodies, Monoclonal; D001345:Autoradiography; D001973:Bromodeoxyuridine / Q000276:immunology / Q000378:metabolism*; D002455:Cell Division; D006801:Humans; D007399:Interphase; D007700:Kinetics; D009101:Multiple Myeloma / Q000473:pathology*; D010950:Plasma Cells / Q000473:pathology*
D000911:Antibodies, Monoclonal; D001973:Bromodeoxyuridine