Comparative carcinogenicity of ring-halogenated 3-methyl-1-phenyltriazenes and their 3,3-dimethyl analogs at equimolar dose levels in male Sprague-Dawley rats.
The carcinogenic activity of 3-methyl-1-phenyltriazene and its four 4- and 2-ring halogenated derivatives was similar to the previously reported carcinogenicity of the corresponding 3,3-dimethyl-1-phenyltriazene analogs tested at equimolar dose levels in adult male Sprague-Dawley rats. The strongest carcinogens in each series were 3-methyl-1-phenyltriazene and 3,3-dimethyl-1-phenyltriazene, respectively. The carcinogenic potency of the individual test compounds decreased with progressive 4- and 2-halogenation of the phenyl ring. The administration of either 3-methyl-1-(2,4,6-trichlorophenyl)- or 3-methyl-1-(2,4,6-tribromophenyl)-triazene gave a negligible tumor yield not different from that observed in the control animals. Moreover, 3,5-dichloro-2-(3,3-dimethyl-1-triazeno)-benzoic acid or its ethyl ester, were found to be strong carcinogens that exclusively induced kidney tumors.
Berger
M R
MR
Kolar
G F
GF
D000818:Animals; D002273:Carcinogens; D004305:Dose-Response Relationship, Drug; D007680:Kidney Neoplasms / Q000139:chemically induced; D008297:Male; D009152:Mutagenicity Tests; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000453:epidemiology / Q000401:mortality; D051381:Rats; D011919:Rats, Inbred Strains; D014226:Triazenes / Q000633:toxicity*
D002273:Carcinogens; D014226:Triazenes; C020772:3-methyl-1-phenyltriazene