The application of 15N-NMR spectroscopy in the problems of nucleoside and nucleotide chemistry.
15N-NMR spectroscopy has been shown to be useful to understand the chemical nature of nitrogen in a biomolecule. We herein report the use of 15N-NMR as a tool for the study of exact location of a substitution on the guanine or uracil moieties in a nucleoside, to understand the implication of a protecting group on the reactivity and the basicity of nitrogen atoms in pyrimidines or in purines and to assign the structure of isomeric N7 and N9 substituted purines.
Remaud
G
G
Department of Bio-organic Chemistry, University of Uppsala, Sweden.
Zhou
X X
XX
Welch
C J
CJ
Chattopadhyaya
J
J
D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009705:Nucleosides; D009711:Nucleotides; D013329:Structure-Activity Relationship
D009705:Nucleosides; D009711:Nucleotides