Experimental central nervous system phaeohyphomycosis following intranasal inoculation of Xylohypha bantiana in cortisone-treated mice.
Experimental central nervous system (CNS) phaeohyphomycosis was established in cortisone-treated mice following intranasal exposure to conidia of Xylohypha bantiana (Cladosporium bantianum, C. trichoides). X. bantiana was recovered from the lungs of 78% of intranasally inoculated normal mice sacrificed within the first 3 days of infection and from 15% at day 28. The fungus was not recovered from the brains of normal mice. In contrast, X. bantiana was recovered from only 33% of the lungs of cortisone-treated mice within the first 3 days of infection. However, the fungus was recovered from the brain of 11% of cortisone-treated mice sacrificed or dying over a 28 day period. Histologically and temporally the CNS disease in cortisone-treated, intranasally inoculated mice was consistent with hematogenous dissemination from a primary pulmonary focus.
Dixon
D M
DM
Department of Biology, Loyola College, Baltimore, MD 21210.
Merz
W G
WG
Elliott
H L
HL
Macleay
S
S
D000818:Animals; D001921:Brain / Q000382:microbiology / Q000473:pathology; D001927:Brain Diseases / Q000382:microbiology* / Q000473:pathology; D003348:Cortisone / Q000008:administration & dosage; D004195:Disease Models, Animal; D005260:Female; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008811:Mice, Inbred DBA; D008813:Mice, Inbred ICR; D003904:Mitosporic Fungi / Q000502:physiology; D009181:Mycoses / Q000382:microbiology* / Q000473:pathology
D003348:Cortisone