Muramyl dipeptide and sleep in rat.
The effect of intravenous administration of a nonpyrogenic (25 micrograms/kg) and pyrogenic (2000 micrograms/kg) dose of N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP) on sleep stages was tested. During the daytime study neither dose changed slow wave sleep. Rapid eye movement sleep was influenced, however, depending on the dose used. Small doses of MDP significantly increased and high doses decreased REM sleep. During the dark phase of the day (evening study) administration of 25 micrograms/kg of MDP caused enhancement of both slow wave sleep and REM sleep.
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Kadlecová
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Masek
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
D000119:Acetylmuramyl-Alanyl-Isoglutamine