Effects of maternal glucose ingestion on human fetal breathing movements at weeks 24 and 28 of gestation.
The incidence of human fetal breathing movements was studied in normal pregnancies before and after administration of 50 g glucose or a placebo (water) at 24 and 28 weeks. Glucose or water was given to the same women on two separate days in a randomised order. No significant differences were present among the results on the placebo-day and the control period of the glucose-day at either gestational age. On the glucose-day, the incidence rose significantly from 3.6 to a maximum of 11.6% at 24 weeks, and from 6.7 to 30.2% at 28 weeks. At both ages the maximum was found 90-120 min after the intake of glucose. It is concluded that already at 24 weeks gestation the human fetus reacts with an increase of fetal breathing movements after the administration of glucose to the mother.
Nijhuis
J G
JG
Jongsma
H W
HW
Crijns
I J
IJ
de Valk
I M
IM
van der Velden
J W
JW
D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000502:physiology; D005865:Gestational Age; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D011247:Pregnancy; D011897:Random Allocation; D012119:Respiration / Q000187:drug effects*
D001786:Blood Glucose; D005947:Glucose