Impact of dose-intense chemotherapy on the development of permanent drug resistance.
Using a somatic mutation theory for drug resistance, dose intense regimens are shown to be superior in increasing the likelihood of no doubly resistant cells and in curing the tumor. Consideration of this model suggests that dose intensity of early chemotherapy cycles should be calculated separately and correlated with treatment outcome.
Coldman
A J
AJ
Division of Epidemiology, Cancer Control Agency of British Columbia, Vancouver, Canada.
Goldie
J H
JH
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D011336:Probability