[Morphology of the pancreas during intra-aortal administration of 5-fluorouracil].
The results of the studies of morphological changes in the pancreas during intraaortal injections of various 5-fluorouracil doses to 44 dogs are reported. It was experimentally established that intraaortal injection of 10 mg 5-fluorouracil per kg of mass for 3 days caused the delay in albumin-synthesizing organella function, without damaging organellas as such. Administration of a cytostatic in a dose of 15 mg per kg of mass did not only cause a drastic decline in the synthesizing activity of cells in acinar parenchyma, but also induced intracellular lesions.
Titova
G P
GP
Laptev
V V
VV
Gaziev
R M
RM
D000818:Animals; D001011:Aorta; D004285:Dogs; D005472:Fluorouracil / Q000008:administration & dosage* / Q000627:therapeutic use; D007269:Injections, Intra-Arterial; D010179:Pancreas / Q000187:drug effects / Q000473:pathology*; D010195:Pancreatitis / Q000188:drug therapy* / Q000473:pathology
D005472:Fluorouracil
Morfologiia podzheludochnoĭ zhelezy pri vnutriaortal'nom vvedenii 5-ftoruratsila.