Ontogeny of bovine neurohypophysial hormone precursors. II. Foetal copeptin, the third domain of the vasopressin precursor.
Vasopressin, MSEL-neurophysin and a glycopeptide, here referred to as copeptin, are three fragments of a common protein precursor processed during axonal transport from hypothalamus to neurohypophysis. Neurohormones and neurophysins purified from 7-9-month-old bovine foetuses have previously been shown to be identical with those found in the adult. Copeptin has now been isolated from 7-9-month and 3-month-old bovine foetuses and chemically characterized. It can be concluded from the nature of the three precursors that the same vasopressin gene is expressed in the adult and the 7-9-month-old foetus.
Levy
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Chauvet
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Chauvet
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Acher
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D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D005333:Fetus / Q000032:analysis; D005796:Genes; D005865:Gestational Age; D006020:Glycopeptides / Q000235:genetics / Q000302:isolation & purification*; D010909:Pituitary Hormones, Posterior / Q000235:genetics / Q000302:isolation & purification*; D011498:Protein Precursors / Q000235:genetics / Q000302:isolation & purification*; D014667:Vasopressins / Q000235:genetics / Q000302:isolation & purification
D006020:Glycopeptides; D010909:Pituitary Hormones, Posterior; D011498:Protein Precursors; C048197:copeptins; D014667:Vasopressins