Renal actions of angiotensin II in renovascular hypertension.
In renal artery stenosis severe enough to cause hypertension, angiotensin II maintains glomerular filtration rate (GFR) both in the initial high renin phase of hypertension and later when plasma levels are normal. Angiotensin II also maintains GFR in less severe stenosis, which does not cause hypertension. This homeostatic action of angiotensin II to maintain GFr has minimal effects on blood flow. In renal-wrap hypertension, plasma renin levels are elevated for longer than after renal artery stenosis, but in other respects this initial phase of the hypertension is similar to that after renal artery stenosis. GFR is reduced, the rate of development of hypertension is accelerated by angiotensin II, and angiotensin II maintains the glomerular filtration fraction. Renal resistance is markedly increased owing to both compression of the kidney by the hypertrophying renal capsule and to angiotensin II. Thus angiotensin II apparently plays a primarily homeostatic role in renovascular hypertension to maintain glomerular ultrafiltration. It is suggested that the angiotensin II may be formed intrarenally and may act on sites other than resistance blood vessels.
Baker Medical Research Institute, Prahran, Victoria, Australia.
W P
WP
Anderson
R L
RL
Woods
K M
KM
Denton
D
D
Alcorn
D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D004285:Dogs; D005919:Glomerular Filtration Rate; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D007668:Kidney / Q000166:cytology / Q000473:pathology / Q000503:physiopathology*; D011817:Rabbits; D012077:Renal Artery / Q000473:pathology*
D000804:Angiotensin II