The prognostic significance of lymphatic vascular space invasion in endometrial adenocarcinoma.
In a histopathological review of 171 cases of endometrial adenocarcinoma, 42 neoplasms demonstrated lymphatic and/or vascular invasion. This finding was significantly correlated with depth of myometrial involvement and stage of disease at operation. Tumour cell type, and histological grade were correlated to a much lesser extent, whilst the patient's age bore no relation. Prognosis was significantly poorer in patients whose adenocarcinomas had invaded lymphatic and/or vascular spaces compared to those whose neoplasms had not. These observations emphasize the importance of considering lymphatic/vascular invasion in staging endometrial adenocarcinomas.
Department of Pathology, University of Manchester.
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Sivridis
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Buckley
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Fox
D000230:Adenocarcinoma / Q000473:pathology*; D004729:Endothelium, Lymphatic / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D005110:Extracellular Space; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D011379:Prognosis; D014594:Uterine Neoplasms / Q000473:pathology*