Lipoprotein lipids and apoproteins during beta-blocker administration: comparison of penbutolol and atenolol.
Serum lipoprotein lipid and apoprotein concentrations were determined in 21 hypertensive men during administration of two beta-blockers, penbutolol or atenolol, for 6 months preceded by a 4 week placebo period. Post-heparin plasma lipoprotein lipase and hepatic lipase activities were also measured. There was a trend to an increase of triglyceride and VLDL triglyceride concentrations during penbutolol administration, but the changes were not significant. Penbutolol also increased the total cholesterol by 11% at 3 months (mainly due to increase of VLDL cholesterol), but this effect diminished at 6 months. Atenolol did not cause any significant change in the total cholesterol but increased HDL cholesterol by 7% at 1 month, the change being due to rise of the HDL3. The HDL3 accounted also for a significant decrease of HDL cholesterol seen in the men receiving penbutolol at 6 months. HDL2 cholesterol as well as the LDL/HDL2 cholesterol ratio remained unchanged in both groups. Neither drug consistently influenced the postheparin plasma lipase activities or the serum apoprotein A or B concentrations. In contrast to an earlier study the results suggest that the clinically most important HDL subfraction, the HDL2, remains unaffected during treatment with beta-blockers.
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M
Välimäki
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L
Maass
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K
Harno
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EA
Nikkilä
D000328:Adult; D001059:Apoproteins / Q000097:blood*; D001262:Atenolol / Q000009:adverse effects* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D008076:Cholesterol, HDL / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010394:Penbutolol / Q000009:adverse effects* / Q000627:therapeutic use; D011412:Propanolamines / Q000009:adverse effects*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D001059:Apoproteins; D008076:Cholesterol, HDL; D008055:Lipids; D008074:Lipoproteins; D011412:Propanolamines; D014280:Triglycerides; D001262:Atenolol; D010394:Penbutolol