Familial elevation of plasma histidine-rich glycoprotein in a family with thrombophilia.
A patient with spontaneous venous thrombotic events, myocardial infarction and a positive family history of thrombosis was investigated for underlying disorders of haemostasis. Abnormally high levels of histidine-rich glycoprotein were found. No other abnormality known or suspected of increasing the risk for thrombosis was present. Elevated levels of histidine-rich glycoprotein appeared to be present in four other members of the family over two generations suggesting a hereditary disorder. Further study on the relation of elevated histidine-rich glycoprotein levels and thrombosis is indicated.
Gaubius Institute TNO, Leiden, The Netherlands.
L
L
Engesser
C
C
Kluft
E
E
Briët
E J
EJ
Brommer
D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation; D001798:Blood Proteins; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011506:Proteins; D013927:Thrombosis / Q000097:blood / Q000235:genetics*; D000099053:Histidine-Rich Glycoprotein
D001798:Blood Proteins; D011506:Proteins; D000099053:Histidine-Rich Glycoprotein