Responses of serotonergic and non-serotonergic neurons in the rat nucleus raphe magnus to systemic lysergic acid diethylamide.
Serotonergic and non-serotonergic neurons in the nucleus raphe magnus were identified by conduction velocities and spontaneous discharge rates. Eight of 13 serotonergic neurons were depressed by lysergic acid diethylamide (LSD) administration (40-50 micrograms/kg, i.p. or i.v.), while the others were non-responsive. Among 38 non-serotonergic neurons, 5 were depressed, 4 were excited and 29 were unaffected by systemic LSD at the same doses. It is thus concluded that LSD could act differently on serotonergic and non-serotonergic neurons in nucleus raphe magnus.
J B
JB
Wei
C Y
CY
Chiang
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002452:Cell Count; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D009431:Neural Conduction / Q000187:drug effects*; D009474:Neurons / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D011903:Raphe Nuclei / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*
D012701:Serotonin; D008238:Lysergic Acid Diethylamide