Lipoatrophic panniculitis: a possible autoimmune inflammatory disease of fat. Report of three cases.
We observed three children with a clinically similar presentation of erythematous nodules that expanded centrifugally leaving lipoatrophy. Areas of lipoatrophy coalesced, resulting in clinical pictures similar to partial or total lipodystrophy. Histologic study revealed a lobular panniculitis with a mixed infiltrate of lymphocytes and mononuclear phagocytes. Of these three children, one had insulin-dependent diabetes mellitus and Hashimoto's thyroiditis, one developed juvenile rheumatoid arthritis, and the third developed insulin-dependent diabetes mellitus, suggesting that the pathogenic mechanism may be an expression of autoimmunity.
Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109-0314.
J K
JK
Billings
S S
SS
Milgraum
A K
AK
Gupta
J T
JT
Headington
J E
JE
Rasmussen
D000273:Adipose Tissue / Q000473:pathology*; D001171:Arthritis, Juvenile / Q000473:pathology; D001284:Atrophy / Q000473:pathology; D001327:Autoimmune Diseases / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000473:pathology; D005260:Female; D006801:Humans; D008060:Lipodystrophy / Q000473:pathology; D008297:Male; D010201:Panniculitis, Nodular Nonsuppurative / Q000473:pathology*; D013967:Thyroiditis, Autoimmune / Q000473:pathology