Inhibition of stimulated dopamine release from striatum slices after hemorrhagic shock in the rat. Protective effect of piracetam.
The antihypoxic effect of piracetam was studied using a hemorrhagic shock model in the rat. Different shock severity was achieved by bleeding of 35% or 50% of estimated blood volume (EBV). Hemorrhagic shock caused an inhibition of K+ induced dopamine release from striatum slices in proportion to the magnitude of hemorrhage, reflecting the degree of membrane damage in dopaminergic transmission structures. Piracetam was effective in preventing the post-hemorrhagic changes in moderate shock and accelerated restitution of post-hemorrhagic release inhibition in severe shock.
Institute of Pathological Biochemistry, Medical Academy Carl Gustav Carus, Dresden, GDR.
J
J
Grässler
C
C
Wustmann
H D
HD
Fischer
J
J
Schmidt
D W
DW
Scheuch
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010889:Piracetam / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000378:metabolism*
D011760:Pyrrolidinones; D011188:Potassium; D004298:Dopamine; D010889:Piracetam