Natural autoreactive H-2-specific serum antibodies in a group of BALB/cBy (H-2d) mice.
Natural autoreactive H-2-specific antibodies were detected by lymphocytotoxic test in sera of 15 BALB/cBy (H-2d) mice maintained in the same cage. The antibodies could be detected only for a short period of time; they reacted strongly with H-2d and H-2s and weakly with H-2k,q,r cells. Such antibodies could not be identified in sera of other groups of mice of the same strain maintained in the same environment. All serum-positive mice had a shorter life span than control mice. However, neither a real link between the antibodies and the disease nor a clear understanding of the disease was achieved.
Cerný-Provaznik
R
R
Kloosterman
T
T
Verkerk
D
D
Vroom
T M
TM
Iványi
P
P
D000818:Animals; D001323:Autoantibodies / Q000302:isolation & purification*; D001327:Autoimmune Diseases / Q000209:etiology; D006183:H-2 Antigens / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D001323:Autoantibodies; D006183:H-2 Antigens