Organization and evolution of D region class I genes in the mouse major histocompatibility complex.
Chromosome walking has been used to study the organization of the class I genes in the D and Qa regions of the MHC of the BALB/c mouse and in the D region of the AKR mouse. Five and eight class I genes are found in the D and Qa regions of the BALB/c mouse, respectively, while the AKR mouse contains only a single class I D region gene that has been identified by transfection as the Dk gene. Restriction map homologies and crosshybridization experiments suggest that the multiple class I genes in the D region of the BALB/c mouse have been generated by unequal crossing-over involving class I genes from the Qa region. The expanded D region of BALB/c and other H-2d haplotype mouse strains appears to be metastable, since evidence for gene contraction in the Dd region has been found in two mutant strains. Thus the D region and also the Qa region class I genes are in a dynamic state, evolving by gene expansion and contraction.
D
D
Stephan
H
H
Sun
K F
KF
Lindahl
E
E
Meyer
G
G
Hämmerling
L
L
Hood
M
M
Steinmetz
D000818:Animals; D005075:Biological Evolution; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D005796:Genes; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics*; D008285:Major Histocompatibility Complex; D051379:Mice; D008806:Mice, Inbred AKR / Q000235:genetics; D008807:Mice, Inbred BALB C / Q000235:genetics; D009693:Nucleic Acid Hybridization
D006183:H-2 Antigens