Effect of age on the pharmacokinetics of vinpocetine (Cavinton) and apovincaminic acid.
The pharmacokinetics of vinpocetine and its main metabolite, apovincaminic acid (AVA), were studied in the aged. Vinpocetine was eliminated with a mean half-life of 2.12 +/- 0.51 h. Total plasma clearance (CL) and distribution coefficient (delta) of the parent drug were 2.2 +/- 0.9 l.kg-1.h-1 and 6.7 +/- 3.7 l.kg-1, respectively. The CL and delta of vinpocetine differed significantly from young subjects but the elimination half-life was not altered. Significant changes in the elimination half-life and plasma clearance of AVA were found, perhaps because of the physiological decrease in renal function.
Department of Pharmacokinetics and Drug Metabolism, Chemical Works of Gedeon Richter Ltd., Budapest, Hungary.
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Miskolczi
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Vereczkey
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L
Szalay
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C
Göndöc
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D001798:Blood Proteins / Q000032:analysis; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D014665:Vasodilator Agents / Q000493:pharmacokinetics*; D014748:Vinca Alkaloids / Q000493:pharmacokinetics*
D001798:Blood Proteins; D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C032858:apovincaminic acid; C013983:vinpocetine