Induction of rat hepatic microsomal epoxide hydrolase by substituted urea herbicides.
Short-term effect of eight substituted phenylurea herbicides has been investigated on the induction of rat hepatic microsomal epoxide hydrolase activity using an HPLC method with unlabelled styrene oxide as substrate. Each compound increased epoxide hydrolase activity 1.5-4 times the controls.
B
B
Schoket
I
I
Vincze
D000818:Animals; D004790:Enzyme Induction; D004851:Epoxide Hydrolases / Q000096:biosynthesis*; D006540:Herbicides / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010671:Phenylurea Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D006540:Herbicides; D010671:Phenylurea Compounds; D004851:Epoxide Hydrolases