Acquired factor XI inhibitors in congenitally deficient patients.
Four factor XI (F XI)-deficient patients are described, all of whom formed circulating anticoagulants against F X1. In the three most severely affected patients (F XI 0%-6% activity), the anticoagulant appeared to have been stimulated by plasma infusion. However, in the milder case (25% F XI activity), no infusion had been documented. The findings in these cases emphasize the diversity of F XI inhibitors in congenitally deficient patients. Awareness of the potential development of these inhibitors will be helpful in both daily management and perioperative care of such patients.
Schnall
S F
SF
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
Duffy
T P
TP
Clyne
L P
LP
D000328:Adult; D000368:Aged; D005172:Factor XI / Q000037:antagonists & inhibitors*; D005173:Factor XI Deficiency / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D010375:Pedigree; D011517:Prothrombin Time
D005172:Factor XI