Unique patterns of androgen regulation of the expression of two genes in murine kidney.
The kidneys of androgen stimulated mice exhibit a hypertrophic response but no hyperplasia or concomitant DNA replication. Androgens increase the expression of several genes in mouse kidney. The response of the beta-glucuronidase gene to testosterone in this tissue is characterized by a 1-2 day lag and relatively slow induction kinetics. The gene coding for kidney androgen-regulated protein (KAP) exhibits quite a different response to the hormone when compared on the basis of initial response to a given dose, dose required to produce maximal response, and apparent sensitivity to low levels of androgen-receptor complexes in renal nuclei. The analysis of the accumulation of the mRNAs produced by these two genes suggests that gene-specific differential sensitivity to androgen receptor complexes governs the development of the cellular male phenotype in this tissue.
Population Council, New York, NY 10021.
J F
JF
Catterall
C S
CS
Watson
B
B
Funkenstein
D000728:Androgens / Q000235:genetics*; D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D005796:Genes; D005809:Genes, Regulator; D005966:Glucuronidase / Q000096:biosynthesis* / Q000235:genetics; D006984:Hypertrophy; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008805:Mice, Inbred A; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D013739:Testosterone / Q000494:pharmacology*
D000728:Androgens; D011506:Proteins; D012333:RNA, Messenger; D013739:Testosterone; D005966:Glucuronidase