Genotoxicity of gamma-irradiation in L5178Y mouse lymphoma cells.
The ability of gamma-irradiation to induce gene mutation at the thymidine kinase locus and gross chromosome aberrations in L5178Y TK+/- 3.7.2C mouse lymphoma cells was evaluated. Positive results were obtained for both end-points. The majority of mutants were found to be small-colony mutants which correlated with the induction of gross chromosome aberrations.
M M
MM
Moore
A
A
Amtower
G H
GH
Strauss
C
C
Doerr
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects*; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D007700:Kinetics; D007940:Leukemia L5178 / Q000473:pathology*; D007942:Leukemia, Experimental / Q000473:pathology*; D051379:Mice; D009154:Mutation; D013937:Thymidine Kinase / Q000235:genetics
D013937:Thymidine Kinase