Ceruletide-induced acute pancreatitis in the dog and its amelioration by exogenous secretin.
Large pharmacological doses of ceruletide administered to conscious dogs by intravenous (i.v.) infusion uniformly induce a severe acute necrotizing pancreatitis within 4 h. High-dose i.v. secretin administered for a period of 24 h after cessation of ceruletide infusion resulted in a significant amelioration of the acute pancreatitis compared to non-secretin-treated dogs with acute pancreatitis. Light microscopy of the pancreas in secretin-treated dogs revealed a significant decrease in edema, polymorphonuclear leukocyte infiltration, cell necrosis and acinar cell vacuolization. Serum amylase levels in secretin-treated dogs were significantly decreased compared to non-secretin-treated dogs. The results of this study suggest that high-dose i.v. secretin exerts a beneficial effect on pre-established, ceruletide-induced acute pancreatitis in dogs.
Department of Medicine, University of Southern California School of Medicine, Los Angeles 90033.
I G
IG
Renner
J R
JR
Wisner
D000208:Acute Disease; D000818:Animals; D002108:Ceruletide; D004285:Dogs; D005260:Female; D008297:Male; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D012633:Secretin / Q000627:therapeutic use*
D012633:Secretin; D002108:Ceruletide