Placental electron microscopy and histochemistry in a case of sialic acid storage disorder.
Morphological alterations in a placenta from a case of infantile sialic acid storage disease are described. Syncytiotrophoblast, villous capillary endothelial cells, amniotic and Hofbaüer cells were filled with membrane-bound inclusions which were either electron-lucent or contained fibrillogranular material. Hydrolysis of slides with neuraminidase demonstrated at six hours Alcian blue material which was not present in normal syncytium. The possibility that a storage disorder such as sialic acid storage disease can be accurately diagnosed by electron microscopy on chorion villous sampling at nine to ten weeks is emphasized.
Jauniaux
E
E
Department of Obstetrics and Gynaecology, Hôpital Universitaire St Pierre, Free University of Brussels, Belgium.
Vamos
E
E
Libert
J
J
Elkhazen
N
N
Wilkin
P
P
Hustin
J
J
D000328:Adult; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008661:Metabolism, Inborn Errors / Q000473:pathology*; D008854:Microscopy, Electron; D019158:N-Acetylneuraminic Acid; D009439:Neuraminidase; D010920:Placenta / Q000473:pathology* / Q000648:ultrastructure; D011247:Pregnancy; D012794:Sialic Acids / Q000378:metabolism*
D012794:Sialic Acids; D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid