Acute interstitial nephritis and non-oliguric renal failure after cefaclor treatment.
A case of acute interstitial nephritis (AIN) developing after cefaclor treatment is reported. Diagnosis was proofed by kidney biopsy and lymphocyte transformation test. The clinical course of the patient with non-oliguric renal failure was favourable. Four weeks after discontinuation of cefaclor treatment the renal function was completely restored and remained stable over the ten-month follow-up period. It is concluded that cefaclor can cause hyperallergic AIN and acute renal failure.
W
W
Pommer
P H
PH
Krause
P A
PA
Berg
H H
HH
Neumayer
M J
MJ
Mihatsch
M
M
Molzahn
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000328:Adult; D001707:Biopsy, Needle; D002433:Cefaclor / Q000009:adverse effects* / Q000627:therapeutic use; D002506:Cephalexin / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects; D008854:Microscopy, Electron; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000473:pathology; D014552:Urinary Tract Infections / Q000188:drug therapy*
D002433:Cefaclor; D002506:Cephalexin