Factor XI kinetics after plasma exchange in severe factor XI deficiency.
Plasma exchange in a patient with factor XI deficiency allowed the determination of the factor XI disappearance time. The decay curve showed a biphasic pattern with a t1/2 of h. After a loading dose by means of plasma exchange with fresh frozen plasma (FFP) up to a factor XI level of 65%, administration of 0.5 liter FFP every 12 h was necessary to maintain the factor XI concentration between 40 and 60%. The clearances of factor XI, calculated from the results of plasma exchange and from the maintenance dose, correlated very well and showed that the t1/2 of factor XI did not change after surgery. The patient underwent major surgery uneventfully but ultimately died 3 1/2 weeks after operation from cerebral damage due to cardiac arrest, which occurred on the 2nd postoperative day.
Nováková
I R
IR
van Ginneken
C A
CA
Verbruggen
H W
HW
Haanen
C
C
D005172:Factor XI / Q000378:metabolism*; D005173:Factor XI Deficiency / Q000097:blood* / Q000628:therapy; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010951:Plasma Exchange
D005172:Factor XI