Unaltered brain membranes after prolonged intake of highly oxidizable long-chain fatty acids of the (n-3) series.
Feeding rats a diet enriched in n-3 polyunsaturated fatty acids (Menhaden oil) increased the content in eicosapentaenoic acid 20:5 n-3 of brain phospholipids. Conversely 22:4 n-6 was reduced. These changes were not associated with alterations in either vitamin E concentration or glutathione peroxidase and catalase activities in cerebrum and cerebellum. No increase in peroxidative damage was found. Interestingly the major very-long-chain fatty acids (22:6 n-3 and 22:5 n-3) were not affected.
INSERM Unité 26, Hôpital Fernand Widal, Paris, France.
J
J
Chaudière
M
M
Clément
F
F
Driss
J M
JM
Bourre
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D004041:Dietary Fats / Q000494:pharmacology; D005227:Fatty Acids / Q000378:metabolism / Q000494:pharmacology*; D005395:Fish Oils / Q000494:pharmacology; D005979:Glutathione Peroxidase / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D008566:Membranes / Q000187:drug effects; D000069463:Olive Oil; D010084:Oxidation-Reduction; D010938:Plant Oils / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000378:metabolism
D004041:Dietary Fats; D005227:Fatty Acids; D005395:Fish Oils; D000069463:Olive Oil; D010938:Plant Oils; D014810:Vitamin E; C033266:Menhaden oil; D002374:Catalase; D005979:Glutathione Peroxidase