Immunohistochemical distribution of ferritin, lactoferrin, and transferrin in granulomas of bovine paratuberculosis.
Granulomatous lesions of bovine paratuberculosis contained ferritin, lactoferrin, and a small amount of transferrin, as demonstrated by the immunohistochemical method. Macrophages in the normal bovine ileum did not contain lactoferrin and transferrin; however, ferritin was found in individual macrophages of Peyer's patches. These results may help elucidate the relationship between intracellular growth of Mycobacterium paratuberculosis and the presence of iron-binding proteins in the granulomas.
Momotani
E
E
Furugouri
K
K
Obara
Y
Y
Miyata
Y
Y
Ishikawa
Y
Y
Yoshino
T
T
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism*; D005290:Ferric Compounds / Q000378:metabolism; D005293:Ferritins / Q000378:metabolism*; D006099:Granuloma / Q000378:metabolism; D007120:Immunochemistry; D007781:Lactoferrin / Q000378:metabolism*; D007782:Lactoglobulins / Q000378:metabolism*; D010283:Paratuberculosis / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism*
D005290:Ferric Compounds; D007782:Lactoglobulins; D014168:Transferrin; D005293:Ferritins; D007781:Lactoferrin