GABA in the PNS: demonstration in enteric neurons.
The hypothesis that gamma-aminobutyric acid (GABA) is a peripheral neurotransmitter was tested by determining whether GABA is present in enteric neurons. GABA was detected in the quail gut using high pressure liquid chromatography. GABA-like immunoreactivity was found in both enteric neural plexuses. Only a few neuronal perikarya, but many fibers were stained in each. GABA-immunoreactive neurons survived for over a week in vitro; therefore, they must be intrinsic to the bowel. These and earlier observations indicate that GABA is a peripheral (enteric) as well as a central neurotransmitter.
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Baetge
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Gershon
D000818:Animals; D006651:Histocytochemistry; D007120:Immunochemistry; D007421:Intestine, Small / Q000294:innervation*; D009197:Myenteric Plexus / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D010525:Peripheral Nerves / Q000378:metabolism*; D011784:Quail / Q000196:embryology; D013368:Submucous Plexus / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid