Hemorrhagic urethritis in female-to-male transsexual. Possible androgen-related phenomena.
This article describes a case of hematuria and urethritis related to androgen stimulation in a female-to-male transsexual receiving testosterone cypionate. Biopsy of the affected urethral tissue revealed periurethral glands which demonstrated a strong positive reaction with immunoperoxidase staining for prostatic specific antigen. When the androgen stimulus was reduced, the patient's symptoms resolved. This report gives evidence for possible androgen-induced pathology in the female urethra.
Cohen
M S
MS
Department of Surgery, University of Texas Medical Branch, Galveston.
Sanchez
R L
RL
D000328:Adult; D005088:Exocrine Glands / Q000187:drug effects*; D005260:Female; D006417:Hematuria / Q000139:chemically induced*; D006801:Humans; D013739:Testosterone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014189:Transsexualism / Q000628:therapy*; D014521:Urethra / Q000187:drug effects*; D014526:Urethritis / Q000139:chemically induced*
D013739:Testosterone; C016131:testosterone 17 beta-cypionate