[Preparation and pharmacologic activity of 1-dimethylaminopropyl-3-methyl-6-chlorquinoxaline-2(1H)-one].
In continuation of previous research 1-dimetilaminopropyl-3-methyl-6-chlorquinoxaline-2(1H)-one was prepared. This compound shows affects on conditioned avoidance response together with analgesic action and inhibition of explorative activity, while it induces only a small degree of motor incoordination and does not protect the animals from toxic doses of strychinine and physostigmine.
A
A
Mulè
L
L
Piu
G
G
Pirisino
F
F
Savelli
P
P
Manca
M
M
Satta
D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D010830:Physostigmine / Q000037:antagonists & inhibitors; D011597:Psychomotor Performance / Q000187:drug effects; D011619:Psychotropic Drugs / Q000138:chemical synthesis*; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D011619:Psychotropic Drugs; D011810:Quinoxalines; C049361:1-dimethylaminopropyl-3-methyl-6-chloroquinoxaline-2(1H)-one; D010830:Physostigmine
Preparazione ed attività farmacologica dell'1-dimetilamminopropil-3-metil-6-clorochinossalin-2(1H)-one.