Structural adaptation of the cardiovascular system in hypertension. Hemodynamic consequences of vascular wall hypertrophy.
The existence of a structural adaptation of the cardiovascular system in hypertension has been known for many years, in fact already since the time of Bright. This paper is concerned with the hemodynamic consequences of the wall thickening of the small arteries and the arterioles. Studies are reported which illustrate the hemodynamic effects of the vascular changes in man, the limited reversibility of these changes and the early occurrence of the wall changes in the course of human hypertension. The pathophysiological role of the structural vascular changes in human hypertension is discussed.
Sivertsson
R
R
Department of Clinical Physiology, Ostra Hospital, University of Göteborg, Sweden.
D000959:Antihypertensive Agents / Q000627:therapeutic use; D005352:Fibromuscular Dysplasia / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000473:pathology*; D009131:Muscle, Smooth, Vascular / Q000473:pathology*; D009206:Myocardium / Q000473:pathology*; D014655:Vascular Resistance / Q000187:drug effects
D000959:Antihypertensive Agents