[Prevention of ischemic damage to the liver monooxygenase system with lidocaine and alpha-tocopherol].
In experiments on rats it was shown that the liver ischemia produces a decrease of the maximal rate of amidopyrine and aniline hydroxylation in microsomes on the 3rd day of the postischemic period. A considerable depth of aniline metabolism inhibition following hepatic ischemia is related to reduced affinity of cytochrome P-450 to substrates of type II. On the 3rd and 14th days of the postischemic period the Michaelis constant and the constant of spectral dissociation for aniline significantly exceeded the given kinetic parameters in control animals. Administration of alpha-tocopherol in combination with lidocaine prevented a decrease of the rate of amidopyrine N-demethylation, the concentrations of cytochromes P-450, b5 and prevented a reduction of cytochrome P-450 affinity to aniline.
Grek
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OR
Sharapov
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D000632:Aminopyrine / Q000493:pharmacokinetics; D000814:Aniline Compounds / Q000493:pharmacokinetics; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006900:Hydroxylation; D007511:Ischemia / Q000201:enzymology / Q000517:prevention & control*; D008012:Lidocaine / Q000627:therapeutic use*; D008099:Liver / Q000098:blood supply* / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010105:Oxygenases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use*
D000814:Aniline Compounds; D000632:Aminopyrine; D014810:Vitamin E; D008012:Lidocaine; D010105:Oxygenases; C023650:aniline
Profilaktika ishemicheskikh povrezhdeniĭ monooksigenaznoĭ sistemy pecheni lidokainom i al'fa-tokoferolom.