Non-random acquisition of ethionine resistance by Chinese hamster fibroblasts. Appendix: acquisition of thermoresistance.
When cells from a single culture are physically separated into cultures exposed and unexposed to the drug, respectively, the cells in the unexposed culture acquire drug resistance at a rate that is much higher than that predicted by Poisson's law. The results are in conflict with the spontaneous mutation hypothesis of Luria and Delbrück. Appendix: cells grown at 37 degrees C acquire temperature resistance when their close relatives are exposed to a high temperature in separate cultures.
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D000818:Animals; D002455:Cell Division; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004351:Drug Resistance; D005001:Ethionine / Q000494:pharmacology*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D008297:Male; D009154:Mutation; D010641:Phenotype; D013696:Temperature
D005001:Ethionine