Cytoplasmic free [Ca2+] is not increased in the platelets of deoxycorticosterone-salt and spontaneously hypertensive rats.
The cytoplasmic free calcium concentration ([Ca2+]i) in the platelets of spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY), deoxycorticosterone-salt hypertensive rats (DOC) and normotensive Sprague-Dawley rats (SD) was measured with the fluorescent dye, quin-2-tetra-acetoxymethyl ester. No significant difference in platelet [Ca2+]i was found between SHR and WKY or between DOC and SD rats. No correlations were found between systolic blood pressure and [Ca2+]i. These results suggest that the elevation of platelet [Ca2+]i does not necessarily accompany hypertension in rats.
K
K
Murakawa
Y
Y
Kanayama
M
M
Kohno
T
T
Kawarabayashi
K
K
Yasunari
T
T
Takeda
A
A
Hyono
D000818:Animals; D001792:Blood Platelets / Q000032:analysis*; D002118:Calcium / Q000032:analysis*; D003900:Desoxycorticosterone; D006973:Hypertension / Q000097:blood / Q000378:metabolism*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY
D003900:Desoxycorticosterone; D002118:Calcium