Ultrastructural changes in the cerebellum of nursling rats given corynetoxin, the aetiological agent of annual ryegrass toxicity.
Nursling rats were given a lethal dose of corynetoxin and the sequential morphological alterations in the cerebellum were examined at daily intervals up to 3 days post-inoculation. Ultrastructural changes were those of cerebral vascular damage, which was usually focal in affected endothelial cells, and resulted in vascular stasis or thrombosis. These changes ultimately constituted a failure of perfusion in focal areas of brain parenchyma supplied by these vessels, resulting in necrosis.
J W
JW
Finnie
T M
TM
Mukherjee
D000818:Animals; D000833:Animals, Suckling; D002531:Cerebellum / Q000098:blood supply / Q000473:pathology / Q000648:ultrastructure*; D005260:Female; D006017:Glycolipids / Q000633:toxicity*; D002542:Intracranial Embolism and Thrombosis / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D051381:Rats
D006017:Glycolipids; C034696:corynetoxins