[Comparative effectiveness of the anti-inflammatory action of diuretics and butadione in an experiment].
Dichlothiazide and butadione were shown to attenuate equally the development of the rat paw inflammatory edema induced by subplantar dextran administration. Ethacrynic acid produced more pronounced antiedematous effect. Also, ethacrynic acid reduced to the highest degree the damp and dry mass of the inflammatory granuloma. Oxadoline and butadione considerably inhibit the formation of granuloma as well. The combined use of diuretics and butadione did not lead to a mutual potentiation of the antiinflammatory effect in exudative and proliferative inflammation.
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IaF
Zverev
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004487:Edema / Q000188:drug therapy / Q000209:etiology; D004976:Ethacrynic Acid / Q000627:therapeutic use; D005260:Female; D006099:Granuloma / Q000188:drug therapy / Q000209:etiology; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D008297:Male; D010653:Phenylbutazone / Q000627:therapeutic use*; D051381:Rats
D000893:Anti-Inflammatory Agents; D004232:Diuretics; D006852:Hydrochlorothiazide; D010653:Phenylbutazone; D004976:Ethacrynic Acid
Sravnitel'naia éffektivnost' protivovospalitel'nogo deĭstviia diuretikov i butadiona v éksperimente.