Stimulation of tryptophan uptake into brain microvessels by D-glutamine.
The uptake of L-tryptophan into isolated porcine microvessels is increased by preincubation with L-glutamine as well as with D-glutamine. This could indicate that gamma-glutamyltranspeptidase is involved in the stimulation of uptake of large neutral amino acids into the brain observed in hyperammonemic conditions.
Gorgievski-Hrisoho
M
M
Colombo
J P
JP
Bachmann
C
C
D000641:Ammonia / Q000097:blood*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000098:blood supply*; D005973:Glutamine / Q000494:pharmacology*; D008833:Microcirculation / Q000378:metabolism; D013237:Stereoisomerism; D013552:Swine; D014364:Tryptophan / Q000378:metabolism*
D005973:Glutamine; D000641:Ammonia; D014364:Tryptophan