Live poliovirus vaccine in patients with chronic glomerulonephritis: effects on renal function and specific antibody response.
Twenty-one patients with chronic glomerulonephritis (GN) (5 with renal failure) received three doses of live trivalent poliovirus vaccine administered orally. The effect of the polio vaccination on the renal function and the titers of antibodies to poliovirus were studied. No significant consequence was observed in renal disease. Before vaccination, titers of poliovirus type 1 and 3 antibodies were significantly decreased as compared to healthy adult subjects. After vaccination, the patients exhibited a significant rise in poliovirus antibody titers for the three serotypes, although some of them failed to develop a fourfold or greater antibody rise to at least one of the three serotypes, especially in the group of patients with renal failure. These results indicate that live poliovirus vaccination is not deleterious in patients with GN and can provide a good protection.
Laboratory of Virology, Faculty of Medicine, Saint-Etienne, France.
B
B
Pozzetto
C
C
Genin
O G
OG
Gaudin
F C
FC
Berthoux
B
B
Alloin
B
B
Laurent
A
A
Ros
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D000917:Antibody Formation; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011051:Poliomyelitis / Q000517:prevention & control; D011055:Poliovirus Vaccine, Oral / Q000276:immunology
D000914:Antibodies, Viral; D011055:Poliovirus Vaccine, Oral