[Effect of quaterin and S-methylmethionine on the intensity of chromatin protein methylation].
It is known that 3-(2,2,2-trimethylhydrazinium) propionate (quaterin) synthetized at the Institute of Organic Synthesis of the Latvian SSR Academy of Sciences has a stimulating effect on cell proliferation in the process of healing wounds and burns. In this connection the above preparation is studied for its effect on the methylation intensity of histones and nonhistone proteins of rat tissues possessing different proliferative activity. For comparison S-methylmethionine (vitamin U), a known stimulator of the methylation reactions, was studied. The experiments conducted have shown that the methylation processes in all the studied tissues (heart, liver, small intestine mucosa, thymus and spleen) depend on the quaterin and the S-methylmethionine effect. On the whole, quaterin 1-6 h after its administration increases, as a rule, the methylation levels of histones and nonhistone proteins. This effect is the least in the thymus and the highest in the liver and spleen. When quaterin is applied daily for 5-15 days considerable changes occur in the levels of chromatin proteins methylation. The data obtained indicate that the processes of chromatin proteins methylation are an important link in the realization of quaterin action on transcription and replication which underlie the proliferative cell response.
Ia B
IaB
Blium
I Ia
IIa
Kalvin'sh
N E
NE
Kucherenko
E Ia
EIa
Lukevits
D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D008297:Male; D008745:Methylation; D008763:Methylhydrazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014814:Vitamin U / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology*
D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; D008763:Methylhydrazines; D014815:Vitamins; D014814:Vitamin U; C050147:3-(2,2,2-trimethylhydrazine)propionate
Vliianie kvaterina i S-metilmetionina na intensivnost' metilirovaniia belkov khromatina.