Dose-response curves for erythrocyte protoporphyrin vs blood lead: effects of iron status.
An increase in erythrocyte protoporphyrin (EP) is one of the most useful indicators of adverse biological response to lead exposure. A nonlinear mathematical model relating EP to blood lead concentration (PbB) was fitted to data in a sample of 1677 U.S. children (ages 2-6 years) in the Second National Health and Nutrition Examination Survey (NHANES II). Iron status was defined by percentage transferrin saturation (PTS). The dose-response curves for EP vs PbB increased systematically with decreasing PTS, largely due to decrease of a parameter proportional to red cell lead-holding capacity with decreasing PTS.
Marcus
A H
AH
U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.
Schwartz
J
J
D000328:Adult; D002648:Child; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000097:blood; D000090463:Iron Deficiencies; D007854:Lead / Q000097:blood*; D007855:Lead Poisoning / Q000097:blood*; D011166:Porphyrins / Q000097:blood*; D011524:Protoporphyrins / Q000097:blood*
D011166:Porphyrins; D011524:Protoporphyrins; D007854:Lead; D007501:Iron