Effects of topically-applied antiperspirant on sweat gland function.
In subjects exposed to a hot environment, short-term topical pretreatment with aluminium zirconium tetrachlorhydrate delayed the onset of visible sweating although it failed to prevent the response. The delay was considered most probably to be due to the occlusive action, in the duct within the upper epidermis, of aluminium-containing conglomerates, which disappear after continuous sweating. However, microanalytical evidence indicated that ionic transport within the fundus secretory cells was also modified.
Institute of Physiology, University of Glasgow, U.K.
S A
SA
McWilliams
I
I
Montgomery
D M
DM
Jenkinson
H Y
HY
Elder
S M
SM
Wilson
A M
AM
Sutton
D000287:Administration, Topical; D000328:Adult; D000535:Aluminum / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D001252:Astringents / Q000008:administration & dosage / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002412:Cations / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D004577:Electron Probe Microanalysis; D006801:Humans; D013545:Sweat Glands / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D013546:Sweating / Q000187:drug effects; D015040:Zirconium / Q000008:administration & dosage / Q000494:pharmacology*
D001252:Astringents; D002412:Cations; D002712:Chlorides; D015040:Zirconium; D000535:Aluminum