Red blood cell membrane lipid peroxidation in continuous ambulatory peritoneal dialysis patients.
We have recently described that in the erythrocytes from uremic patients on chronic hemodialysis, the pentose-phosphate shunt is defective, the membrane concentrations of malonyldialdehyde, resulting from peroxidation of polyunsaturated fatty acids in the membranes themselves, are increased, and the concentrations of vitamin E, an antioxidizing agent, are reduced. In the present study we have analyzed these same metabolic aspects in a group of uremic patients in continuous ambulatory peritoneal dialysis. We have found normal function of the pentose-phosphate shunt, slightly elevated concentrations of malonyldialdehyde compared to controls, but definitely lower than in chronic hemodialysis patients, and higher tocopherol concentrations than in both controls and chronic hemodialysis patients.
M
M
Taccone-Gallucci
O
O
Giardini
R
R
Lubrano
V
V
Mazzarella
D
D
Bandino
S
S
Khashan
O
O
Mannarino
M
M
Elli
M
M
Cozzari
U
U
Buoncristiani
D000328:Adult; D000368:Aged; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008563:Membrane Lipids / Q000097:blood*; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D014810:Vitamin E / Q000097:blood
D005231:Fatty Acids, Unsaturated; D008054:Lipid Peroxides; D008563:Membrane Lipids; D014810:Vitamin E; D008315:Malondialdehyde; D006861:Hydrogen Peroxide