Hepatotoxicity of mebendazole. Relationship with serum concentrations of the drug.
We report the case of a 47-year-old female patient, suffering from multiple hydatid cysts of the liver, in whom hepatitis developed after mebendazole treatment. Clinical manifestations of hypersensitivity were absent. A correlation was found between serum mebendazole concentrations and the degree of cytolysis; this is compatible with a direct hepatotoxic effect of mebendazole.
Bekhti
A
A
Secteur de Gastroentérologie, Institut de Médecine, Hôpital de Bavière, Liège, Belgique.
Pirotte
J
J
D000410:Alanine Transaminase / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000201:enzymology / Q000209:etiology; D004444:Echinococcosis, Hepatic / Q000188:drug therapy; D005260:Female; D006801:Humans; D008463:Mebendazole / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D008875:Middle Aged
D008463:Mebendazole; D000410:Alanine Transaminase