Increase in mouse liver weight following feeding of ammonium perfluorooctanoate and related fluorochemicals.
The weight of the mouse liver following feeding of ammonium perfluorooctanoate, ammonium perfluorononanoate, Telomer B ammonium sulfate, and WG-III was increased in a dose-dependent manner. Dietary levels of 3 ppm or greater ammonium perfluorooctanoate for either 14 or 21 days produced a significant elevation in liver weight both on an absolute and on an organ/body weight ratio basis. Similarly, ammonium perfluorononanoate produced significant increases at the lowest level tested, 3 ppm. Telomer B ammonium sulfate and WG-III also produced liver weight increases but at higher feeding levels. The striking increase in liver weight following relatively short-term exposures in mice makes this a useful screening test for comparing the liver-enlarging capacity of ammonium perfluorooctanoate and related fluorochemicals.
Central Research and Development Department, E.I. du Pont de Nemours and Company, Haskell Laboratory for Toxicology and Industrial, Newark, DE 19714.
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Kennedy
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002210:Caprylates / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005466:Fluorocarbons / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects
D002210:Caprylates; D005466:Fluorocarbons; C023036:perfluorooctanoic acid