Boron distribution analysis by alpha-autoradiography.
The distribution of the boron-10 compound, Na2 10B12H11SH, which is now in clinical use for boron neutron capture therapy for brain tumors, was studied topographically and quantitatively in rats using neutron-induced alpha-autoradiography. Transplanted intracerebral tumors in Sprague-Dawley rats were used. In the normal brain, only a minute amount of 10B (less than 1 microgram 10B/cm3) was found in the brain parenchyma, except for the infundibulum and area postrema. Boron-10 accumulated in the brain tumors. The tumor-to-blood concentration ratio of 10B increased with time after injection and reached unity 12 hr after injection. The tumor concentration calculated at that time was 18 micrograms 10B/cm3. This study clearly shows that this 10B compound accumulates in the transplanted rat tumors in the brain and that tumor concentration and tumor-to-blood ratio of 10B can provide a sufficient condition for brain tumor treatment.
M
M
Abe
K
K
Amano
K
K
Kitamura
J
J
Tateishi
H
H
Hatanaka
D000818:Animals; D001345:Autoradiography; D001895:Boron / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D002478:Cells, Cultured; D007554:Isotopes / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D009502:Neutrons; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D007554:Isotopes; D001895:Boron