Ag(c): recognition by a monoclonal antibody.
A monoclonal antibody directed against human apolipoprotein B, which was previously shown in family studies to detect allelic variations (J Biol Chem 1984; 259:6423-6430), has now been identified with the Ag(c) factor. This identification allows the location of the Ag system on the structural gene for apolipoprotein B and on the short arm of human chromosome 2. The epitope corresponding to Ag(c) is located within the amino acid sequence common to apolipoproteins B-100 and B-48. Since a single molecule of apolipoprotein B-100 is present on human LDL, individual LDL possesses either the epitope corresponding to Ag(c) or that corresponding to Ag(g). These studies on allelic variation among human apolipoprotein B species parallel similar studies in animals in which a relationship to atherosclerosis was found.
M T
MT
Robinson
V N
VN
Schumaker
R
R
Butler
K
K
Berg
L K
LK
Curtiss
D000483:Alleles; D000911:Antibodies, Monoclonal; D001055:Apolipoproteins B / Q000235:genetics* / Q000276:immunology; D005787:Gene Frequency; D014644:Genetic Variation; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D008074:Lipoproteins / Q000032:analysis / Q000235:genetics*; D010641:Phenotype; D011863:Radioimmunoassay
D000911:Antibodies, Monoclonal; D001055:Apolipoproteins B; D008074:Lipoproteins