Studies with a plant fungicide, imazalil, with vapor-phase activity, in the therapy of human alternariosis.
The use of a plant fungicide, the imidazole imazalil, in the therapy of human alternariosis is described. The patient's disease involved the palate, nose and sinuses, and had been unresponsive to conventional therapy. Imazalil has been used to treat Alternaria infections of plant materials. The patient's isolate was susceptible in vitro. We also showed that the drug was inhibitory to fungi in vitro as a vapor, not requiring contact by diffusion through agar or broth. The drug was used topically, by installation and irrigation, in this case and administered orally in doses of up to 1 200 mg daily, for 6 months. Peak serum concentrations exceeded 4 mcg/ml. The infection was arrested but not cured. The drug was tolerated without evident toxicity, though an unpleasant taste and nausea at high doses were limiting.
R L
RL
Stiller
D A
DA
Stevens
D000284:Administration, Oral; D000287:Administration, Topical; D000528:Alternaria / Q000187:drug effects; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D009059:Mouth Diseases / Q000188:drug therapy / Q000382:microbiology; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D009325:Nausea / Q000139:chemically induced; D009668:Nose Diseases / Q000188:drug therapy / Q000382:microbiology; D010159:Palate / Q000382:microbiology; D010254:Paranasal Sinus Diseases / Q000188:drug therapy / Q000382:microbiology
D007093:Imidazoles; C017435:enilconazole