Clinicopathologic correlation of lipidization and detachment of the retinal pigment epithelium.
A 49-year-old woman had a few small drusen-like lesions and one larger area of depigmentation in the right fundus. The pin-point lesions corresponded to single enlarged retinal pigment epithelial cells with lipid accumulation and the larger area represented a small, localized retinal pigment epithelial detachment (soft druse). Lipoidal degeneration of individual retinal pigment epithelial cells may be a mechanism of nodular drusen formation. The soft druse was associated with thickening of the basement membrane of the retinal pigment epithelium.
el Baba
F
F
Green
W R
WR
Fleischmann
J
J
Finkelstein
D
D
de la Cruz
Z C
ZC
D005260:Female; D006801:Humans; D008064:Lipidoses / Q000473:pathology; D008853:Microscopy; D008854:Microscopy, Electron; D008875:Middle Aged; D010857:Pigment Epithelium of Eye / Q000473:pathology; D012163:Retinal Detachment / Q000473:pathology*