Inflammatory response to viscoelastic materials.
Healon, Amvisc, or Viscoat was injected into the corneal stroma of 36 normal rabbit eyes. Twelve additional rabbit eyes were used as controls by performing a sham procedure. Twelve rabbits were euthanized at one day and the remainder seven days after injection. The eyes were enucleated and examined by light microscopy. No control eyes had detectable inflammation. Only Viscoat produced mild inflammation at seven days, but this was statistically significant only at p = 0.182. There appears to be little difference in the inflammatory response of these three viscoelastic substances.
Department of Ophthalmology, University of Missouri-Columbia School of Medicine.
S J
SJ
McKnight
J
J
Giangiacomo
E
E
Adelstein
D000818:Animals; D002807:Chondroitin / Q000009:adverse effects; D002809:Chondroitin Sulfates; D003315:Cornea / Q000187:drug effects / Q000473:pathology; D004338:Drug Combinations / Q000009:adverse effects; D006820:Hyaluronic Acid / Q000009:adverse effects*; D007634:Keratitis / Q000139:chemically induced* / Q000473:pathology; D011817:Rabbits; D014783:Viscosity
D004338:Drug Combinations; C501944:chondroitin sulfate, sodium hyaluronate drug combination; D006820:Hyaluronic Acid; D002807:Chondroitin; D002809:Chondroitin Sulfates