Studies on the effect of concanavalin A on the metabolism of low density lipoproteins in skin fibroblasts.
Concanavalin A bound to the cell surface decreased the binding and internalization of low density lipoproteins (LDL) to human skin fibroblasts. However, concanavalin A failed to inhibit the degradation of preinternalized LDL. Concanavalin A inhibited the activation of acyl-CoA: cholesterol acyltransferase by LDL. These results strongly suggest that concanavalin A inhibits the metabolism of LDL in human skin fibroblasts by affecting the receptor binding and internalization of LDL.
Atherosclerosis Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905.
H
H
Matsuura
S
S
Ranganathan
M
M
Yamamoto
B A
BA
Kattke
D002478:Cells, Cultured; D002738:Chloroquine / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D011973:Receptors, LDL / Q000187:drug effects; D012867:Skin / Q000166:cytology / Q000378:metabolism*
D008077:Lipoproteins, LDL; D011973:Receptors, LDL; D003208:Concanavalin A; D002738:Chloroquine