[Isolation of split and whole-virion tick-borne encephalitis vaccines in an experiment and the characteristics of their immunogenic and antigenic properties].
The split preparation, obtained by the treatment of purified and concentrated tick-borne encephalitis virus with 0.5% Tween-80 and ether and inactivated with formalin at a minimal concentration of 1:10,000, did not contain the active virus. After the removal of the detergent, the preparation retained its antigenic and immunogenic properties.
Osipova
E G
EG
Solianik
R G
RG
Fedorov
Iu V
IuV
Tymchishin
P N
PN
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000276:immunology*; D002642:Chick Embryo; D004353:Drug Evaluation, Preclinical; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000517:prevention & control; D007114:Immunization; D008722:Methods; D051379:Mice; D011817:Rabbits; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000276:immunology / Q000302:isolation & purification; D014765:Viral Vaccines / Q000276:immunology / Q000302:isolation & purification*; D014771:Virion / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
Poluchenie rasshcheplennoĭ i tsel'novirionnoĭ vaktsin kleshchevogo éntsefalita v éksperimente i kharakteristika ikh immunogennykh i antigennykh svoĭstv.