TPP+ inhibits Na+-stimulated Ca2+ efflux from brain mitochondria.
Tetraphenylphosphonium (TPP+) inhibits Na+-stimulated Ca2+ efflux from brain mitochondria. Half inhibition is observed when 1.10(-8)M TPP+ is present in the medium. Some other lipophylic cations show similar effect. TPP+ must be used carefully for measuring transmembrane potential because of its effects on the system studied. TPP+ will be a useful tool to study Ca-transport system in mitochondria.
J S
JS
Karadjov
Kudzina LYu
V P
VP
Zinchenko
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009861:Onium Compounds / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D011817:Rabbits; D012964:Sodium / Q000494:pharmacology
D009861:Onium Compounds; D009943:Organophosphorus Compounds; D012964:Sodium; D002118:Calcium; C013289:tetraphenylphosphonium