Neural control of the forms of acetylcholinesterase in slow mammalian muscles.
The 'heavy', collagen-tailed form of acetylcholinesterase (AChE), having a s(0)20,w of 16S in mammals, occurs at vertebrate muscle endplates and has been widely regarded as a marker of neuronal influence on muscle in vivo. However, an interesting exception has been described by Bacou et al., in a previous report in Nature. They found, in a slow-twitch muscle of the rabbit, that after denervation the 16S form of AChE increases markedly, rather than disappearing. Such a phenomenon would modify current concepts of neuromuscular regulation. We report here, however, that this exception is apparent rather than real in terms of endplate AChE regulation.
J
J
Lai
J
J
Jedrzejczyk
J A
JA
Pizzey
D
D
Green
E A
EA
Barnard
D000110:Acetylcholinesterase / Q000302:isolation & purification / Q000378:metabolism*; D000818:Animals; D002499:Centrifugation, Density Gradient; D006168:Guinea Pigs; D007527:Isoenzymes / Q000302:isolation & purification / Q000378:metabolism*; D008970:Molecular Weight; D009121:Muscle Denervation; D009132:Muscles / Q000201:enzymology* / Q000294:innervation; D009928:Organ Specificity; D011817:Rabbits; D013045:Species Specificity
D007527:Isoenzymes; D000110:Acetylcholinesterase