Survival and repair of potentially lethal radiation damage in confluent vascular smooth muscle cell cultures.
Confluent cultures of rat aortic smooth muscle cells demonstrated dose-dependent potentially lethal damage repair (PLDR), with an average repair factor of 4 for a 10 Gy dose. PLDR occurred with a half-time of 2 hours and was nearly maximal by 8 h. Among other factors, PLDR may contribute to the radioresistance of large blood vessels.
Rosen
E M
EM
Goldberg
I D
ID
Myrick
K V
KV
Halpin
P A
PA
Levenson
S E
SE
D000818:Animals; D001011:Aorta; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured; D004307:Dose-Response Relationship, Radiation; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000473:pathology / Q000528:radiation effects*; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains