Direct comparison of hallucinogenic phenethylamines and D-amphetamine on dorsal raphe neurons.
We compared the effects of the hallucinogens 2,5-dimethoxy-4-methylamphetamine (DOM), mescaline and the simulant D-amphetamine, applied by microiontophoresis to rat dorsal raphe (DR) units. DR neuron firing rate was relatively insensitive to DOM and unaffected by mescaline, but was clearly inhibited by D-amphetamine. Intravenous DOM usually inhibited, but this effect was correlated with blood pressure changes; i.v. D-amphetamine produced inconsistent responses. These results suggest that most of the effects seen on i.v. administration of phenethylamines are not mediated directly on the serotonergic cell.
Penington
N J
NJ
Reiffenstein
R J
RJ
D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology*; D006213:Hallucinogens / Q000494:pharmacology*; D008297:Male; D008635:Mescaline / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects*; D010627:Phenethylamines / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology
D006213:Hallucinogens; D010627:Phenethylamines; D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine; D012701:Serotonin; D008635:Mescaline; D003913:Dextroamphetamine