Emetic activity of the trichothecene 15-acetyldeoxynivalenol in swine.
The emetic activity of 15-acetyldeoxynivalenol (15-ADON), a deoxynivalenol (DON) precursor, was evaluated in swine over a dose range of 25-200 micrograms/kg body weight and found to be very similar to that of DON. The minimum effective oral doses for 15-ADON and DON were 75 and 50 micrograms/kg, respectively, with 3/15 of the 15-ADON- and 4/15 of the DON-treated pigs exhibiting emesis, over the total dose range. The minimum effective ip doses for 15-ADON and DON were also 75 and 50 micrograms/kg, respectively, with 9/15 pigs in each group exhibiting emesis, over the total dose range. For pigs receiving 15-ADON and DON ip, increased dosage was associated with decreased average time to vomition, increased duration of emesis and increased average number of vomitions.
Department of Food Science and Human Nutrition, Michigan State University, East Lansing 48824-1224.
J J
JJ
Pestka
W S
WS
Lin
E R
ER
Miller
D000818:Animals; D004305:Dose-Response Relationship, Drug; D012044:Regression Analysis; D012717:Sesquiterpenes / Q000633:toxicity*; D013552:Swine; D014255:Trichothecenes / Q000378:metabolism / Q000633:toxicity*; D014839:Vomiting / Q000139:chemically induced*
D012717:Sesquiterpenes; D014255:Trichothecenes; C046760:15-acetyldeoxynivalenol; C007262:deoxynivalenol