Synthesis of phospholipids and nucleoside-phospholipid conjugates via hydrogenphosphonate intermediates.
Chemical synthesis of nucleoside-phospholipid conjugates based on hydrogenphosphonate chemistry has been achieved via coupling of 1,2-dipalmitoylglycero-3-H-phosphonate with suitable protected nucleosides or via coupling of nucleoside H-phosphonates with 1,2-dipalmitoylglycerol. It was also found that 1,2-dipalmitoylglycero-3-H-phosphonate, which is a stable compound, can serve as a convenient intermediate in the synthesis of various phospholipids.
Lindh
I
I
Department of Organic Chemistry, Arrhenius Laboratory, University of Stockholm, Sweden.
Stawinski
J
J
D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D063065:Organophosphonates; D010743:Phospholipids / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D063065:Organophosphonates; D010743:Phospholipids