R 56865 prevents electrical and mechanical signs of ouabain intoxication in guinea-pig papillary muscle.
The effect of the new compound R 56865 on ouabain-induced intoxication (8 X 10(-7) mol/l) was studied in guinea-pig papillary muscle. The positive inotropism induced by ouabain was not impaired by R 56865. Mechanical signs of intoxication, e.g. extrasystoles and contracture, as well as the development of spike-like action potentials could be prevented by pretreatment with R 56865 (3 X 10(-10)-10(-6) mol/l). We speculate that this new compound prevents ouabain-induced Ca overload of cardiac muscle.
Janssen Research Foundation, Neuss, F.R.G.
B
B
Vollmer
C
C
Meuter
P A
PA
Janssen
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000503:physiopathology; D052160:Benzothiazoles; D002118:Calcium / Q000502:physiology; D004594:Electrophysiology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D010042:Ouabain / Q000037:antagonists & inhibitors* / Q000633:toxicity; D010210:Papillary Muscles / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
D052160:Benzothiazoles; D010880:Piperidines; D013844:Thiazoles; D010042:Ouabain; C054551:R 56865; D002118:Calcium