Identification of three additional members of rat protein kinase C family: delta-, epsilon- and zeta-subspecies.
Three types of cDNA clone of the protein kinase C family termed delta, epsilon and zeta were newly identified by molecular cloning and sequence analysis. These members have a common structure that is closely related to, but clearly different from the other four known members of the family which have alpha-, beta I-, beta II- and gamma-sequences, although the zeta-cDNA available at present does not contain a complete reading frame for a protein kinase C molecule. The diverse heterogeneity of the enzyme seems to be an important factor in determining the mode of response of many tissues and cell types to a variety of external stimuli.
Biotechnology Laboratories, Takeda Chemical Industries, Osaka, Japan.
Y
Y
Ono
T
T
Fujii
K
K
Ogita
U
U
Kikkawa
K
K
Igarashi
Y
Y
Nishizuka
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000201:enzymology*; D003001:Cloning, Molecular; D004247:DNA / Q000302:isolation & purification; D007527:Isoenzymes / Q000235:genetics*; D008969:Molecular Sequence Data; D011493:Protein Kinase C / Q000235:genetics*; D051381:Rats
D007527:Isoenzymes; D004247:DNA; D011493:Protein Kinase C