Activity of ibopamine on central nervous system in mice and rats.
Ibopamine (SB-7505), the 3,4-diisobutyryl ester of N-methyldopamine has proved to be able to induce cardiovascular and renal effects after oral administration which were comparable to those of dopamine injected intravenously. In the present paper ibopamine was investigated on some behavioural, motility and biochemical tests with a view to assaying its possible activity on the central nervous system (CNS). The results obtained show that ibopamine has no significant activity on CNS.
R
R
Ferrini
G
G
Miragoli
R
R
Sala
A
A
Reggiani
D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects*; D003846:Deoxyepinephrine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology*; D004298:Dopamine / Q000031:analogs & derivatives*; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology; D013045:Species Specificity; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D000067956:Adenylyl Cyclase Inhibitors; D004232:Diuretics; D011954:Receptors, Dopamine; D012110:Reserpine; C023487:ibopamine; D001058:Apomorphine; D003846:Deoxyepinephrine; D004298:Dopamine