Inhibition of human neutrophil bacteriocidal activity by extracellular substance from slime-producing Staphylococcus epidermidis.
The role of slime produced by Staphylococcus epidermidis as a virulence factor has been investigated by preincubating human neutrophils in fractions of extracellular material from cultures of slime-producing and non-slime-producing S. epidermidis. Extracellular product (molecular weight greater than 300,000) from slime-producing S. epidermidis did not affect neutrophil phagocytosis but did produce a generalized loss of bacteriocidal activity which was not found with non-slime-producing S. epidermidis, or broth.
M A
MA
Noble
P E
PE
Reid
C M
CM
Park
V Y
VY
Chan
D001688:Biological Products / Q000302:isolation & purification / Q000494:pharmacology; D003470:Culture Media; D008970:Molecular Weight; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010587:Phagocytosis; D013212:Staphylococcus epidermidis / Q000254:growth & development* / Q000378:metabolism
D001688:Biological Products; D003470:Culture Media