Insufficient transplacental digoxin transfer in severe hydrops fetalis.
A case of severe nonimmune hydrops fetalis caused by supraventricular tachycardia is presented. Maternal treatment with digoxin and the subsequent addition of verapamil and propranolol failed to be effective. Simultaneous measurement of maternal serum and cord blood digoxin levels showed insufficient transplacental digoxin transfer. Other modalities of treatment are discussed.
Department of Obstetrics and Gynecology, Hadassah University Medical Center, Jerusalem, Israel.
J S
JS
Younis
M
M
Granat
D000328:Adult; D004077:Digoxin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy*; D005260:Female; D005315:Fetal Diseases / Q000188:drug therapy*; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011433:Propranolol / Q000627:therapeutic use; D013617:Tachycardia, Supraventricular / Q000188:drug therapy*; D014700:Verapamil / Q000627:therapeutic use
D004077:Digoxin; D011433:Propranolol; D014700:Verapamil