Clinical and anatomical observations of a two-headed lamb.
The clinical and anatomical features of a live-born diprosopic lamb are described. There are no complete anatomical analyses of two-faced lambs in the literature despite the frequency of conjoined twinning in sheep. The lamb had two heads fused in the occipital region. Each head had two eyes. The pinnae of the medial ears were fused. Caudal to the neck the lamb appeared grossly normal. The lamb was unable to raise its heads or stand. Both heads showed synchronous sucking motions and cranial reflexes were present. Nystagmus, strabismus, and limb incoordination were present. The respiratory and heart rates were elevated. There was a grade IV murmur over the left heart base and a palpable thrill on the left side. Each head possessed a normal nasopharynx, oropharynx, and tongue. There was a singular laryngopharnyx and esophagus although the hyoid apparatus was partially duplicated. The cranial and cervical musculature reflected the head duplications. The aortic trunk emerged from the right ventricle just to the right of the conus arteriosus. A ventricular septal defect, patent foramen ovale, and ductus arteriosus were present along with malformed atrioventricular valves. Brainstem fusion began at the cranial medulla oblongata between cranial nerves IX and XII. The cerebella were separate but small. The ventromedial structures from each medulla oblongata were compressed into an extraneous midline remnant of tissue which extended caudally to the level of T2. The clinical signs therefore reflected the anatomical anomalies. A possible etiology for this diprosopus might be the presence early in development of an excessively large block of chordamesoderm. This would allow for the formation of two head folds and hence two "heads."
K R
KR
Fisher
G D
GD
Partlow
A F
AF
Walker
D000818:Animals; D002490:Central Nervous System / Q000473:pathology; D003391:Cranial Nerves / Q000473:pathology; D005121:Extremities / Q000473:pathology; D005260:Female; D006257:Head / Q000473:pathology; D009333:Neck / Q000473:pathology; D012756:Sheep; D012757:Sheep Diseases / Q000473:pathology* / Q000503:physiopathology; D014428:Twins, Conjoined / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*