Penicillin concentrations in serum following weekly injections of benzathine penicillin G.
Twelve patients with syphilis were treated weekly with injections of 1.44 g (2.4 X 10(6) IU) of benzathine penicillin G for up to 3 weeks. Almost daily, serum penicillin concentrations were measured by a sensitive microbiological agar cup method. An individual and interindividual variation was found. Concentrations below the recommended 0.018 micrograms/ml were found 7 days after the first or second injection in 5 samples. Shorter intervals between injections are recommended.
Hagdrup
H K
HK
Lange Wantzin
G
G
Secher
L
L
Rosdahl
V T
VT
D000042:Absorption; D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010400:Penicillin G / Q000097:blood*; D010401:Penicillin G Benzathine / Q000097:blood* / Q000627:therapeutic use; D013587:Syphilis / Q000188:drug therapy
D010400:Penicillin G; D010401:Penicillin G Benzathine