Groove selectivity in the interaction of 9-aminoacridine-4-carboxamide antitumor agents with DNA.
Theoretical quantitative evaluation of the intercalative binding to DNA of the new antitumor drug 9-aminoacridine-4-carboxamide indicates that, in contradiction with a recently proposed model, the compound should show specificity for interaction with the major (and not minor) groove of GC sequences.
Institut de Biologie Physico-Chimique, Laboratoire de Biochimie Théorique associé au CNRS, Paris, France.
K X
KX
Chen
N
N
Gresh
B
B
Pullman
D000970:Antineoplastic Agents; D001483:Base Sequence; D004247:DNA; D006860:Hydrogen Bonding; D007364:Intercalating Agents; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D007364:Intercalating Agents; D004247:DNA