Beta-substituted ethylsulfonyl chlorides as 5'-OH protecting groups in nucleoside and nucleotide chemistry.
Three beta-substituted ethylsulfonyl chlorides 1-3 were synthesized and their usefulness as 5'-OH protecting groups for oligonucleotide synthesis studied. The formation of the corresponding 5'-beta-R-ethyl-sulfonic acid esters was investigated in respect to fast and complete capping. The 5'-sulfonates 4-9 were prepared and the deprotection was studied using reversed phase HPLC as the analytical tool.
Fakultät für Chemie, Universität Konstanz, FRG.
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Reiner
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Pfleiderer
D002851:Chromatography, High Pressure Liquid; D006843:Hydrocarbons, Chlorinated / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009705:Nucleosides; D009711:Nucleotides; D009841:Oligonucleotides / Q000138:chemical synthesis*
D006843:Hydrocarbons, Chlorinated; D007202:Indicators and Reagents; D009705:Nucleosides; D009711:Nucleotides; D009841:Oligonucleotides