[Experimental study on acute ulceration in association with obstructive jaundice--with special reference to the effect of biliary drainage on gastric mucosal blood flow and energy kinetics].
The mechanism of acute ulceration in association with obstructive jaundice was studied experimentally by measurement of gastric mucosal blood flow and energy kinetics. The effect of biliary drainage was also evaluated. Three hundred thirty nine SD male rats weighing about 250 gr were grouped as follows; control group--Sham operation, obstructive jaundice group-2 weeks after ligation and dissection of the choledochus, and biliary drainage group-- A silicone tube was inserted and opened after 2 weeks of obstructive jaundice. All the animals were stressed by water immersion and ulcer index, gastric mucosal blood flow, gastric mucosal energy kinetics and liver function were assessed. The obstructive jaundice group showed significant higher ulcer index and lower gastric mucosal blood flow and energy kinetics than the control group. These factors of the biliary drainage group started to improve soon after biliary drainage and reached to the levels of the control group. In conclusion, reduction of defensive factors caused by jaundice was proved to play an important role in acute ulceration associating obstructive jaundice. Biliary drainage improves both gastric mucosal blood flow and gastric mucosal energy kinetics so that it is preventive against acute ulceration.
Narui
H
H
Sasaki
I
I
Konno
Y
Y
Kamiyama
Y
Y
D000208:Acute Disease; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002779:Cholestasis / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D004322:Drainage; D004734:Energy Metabolism; D005753:Gastric Mucosa / Q000098:blood supply* / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000209:etiology*
D000255:Adenosine Triphosphate