Lack of correlation between cortical levels of choline acetyltransferase and learning scores in rats with globus pallidus lesions.
Previous work has shown that rats with lesions of the globus pallidus (GP) exhibit a generalized learning impairment. Data are presented suggesting that this impairment is not due to inadvertent damage to the nucleus basalis magnocellularis. Rats with GP lesions evidenced a significant visual discrimination learning loss and a significant reduction in cortical choline acetyltransferase (ChAT) activity. However, there was no significant correlation between the severity of the learning loss and the amount of reduction of cortical ChAT activity.
Thompson
R
R
Gibbs
R B
RB
Ristic
G A
GA
Cotman
C W
CW
Yu
J
J
D000818:Animals; D001480:Basal Ganglia Diseases / Q000150:complications / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D004193:Discrimination Learning; D005917:Globus Pallidus; D007859:Learning Disabilities / Q000201:enzymology* / Q000209:etiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014796:Visual Perception
D002795:Choline O-Acetyltransferase