[Substances with antibacterial and antifungal activity. I. Synthesis and microbiologic activity of imidazolylmethylanilines].
The synthesis and antifungal activities of many derivatives of 1-(2-imidazolylmethyl)aniline and of 1-(4-imidazolylmethyl)aniline are reported. Antimicrobial data in comparison with miconazole show that many compounds containing chlorine atoms and nitro group exhibit an interesting antimycotic activity. The results obtained are discussed on the basis of structure-activity relationships.
Scalzo
M
M
Biava
M
M
Cerreto
F
F
Porretta
G C
GC
Panico
S
S
Simonetti
N
N
Villa
A
A
D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000814:Aniline Compounds; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D007093:Imidazoles
Ricerche su sostanze ad attività antibatterica e antifungina. Nota I. Sintesi ed attività microbiologica di derivati dell'imidazolilmetilanilina.