[Regulation of isoproterenol-induced salivary gland hyperplasia in young and old mice by substances affecting the serotonin- and dopaminergic systems].
Isoproterenol-induced hyperplastic reaction has demonstrated decreased proliferative potency of salivary gland tissue in adult mice. Activation of serotoninergic mechanisms of lymphoid regulation by serotonin administration also decreased salivary gland hyperplastic reaction, predominantly in young mice. Dopamine administration enhanced the reaction in adult mice, it reaching the level observed in young animals. The number of spleen activated low density lymphocytes decreased in the case of serotonin-induced inhibition of hyperplastic reaction to isoproterenol and increased in the case of reaction stimulation. These lymphocytes have been previously shown to regulate salivary gland tissue proliferation in response to isoproterenol.
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Dontsov
D000375:Aging / Q000187:drug effects*; D000818:Animals; D005260:Female; D005620:Freund's Adjuvant / Q000494:pharmacology; D006965:Hyperplasia / Q000139:chemically induced / Q000473:pathology; D007545:Isoproterenol / Q000494:pharmacology*; D007980:Levodopa / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D011954:Receptors, Dopamine / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects*; D012469:Salivary Glands / Q000187:drug effects* / Q000473:pathology; D012701:Serotonin / Q000494:pharmacology; D013997:Time Factors
D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012701:Serotonin; D007980:Levodopa; D005620:Freund's Adjuvant; D007545:Isoproterenol
Reguliatsiia indutsirovannoĭ izoproterenolom giperplazii sliunnykh zhelez molodykh i starykh mysheĭ veshchestvami, vliiaiushchimi na serotonin- i dofaminergicheskie sistemy.