CP-54,883 a novel chlorine-containing polyether antibiotic produced by a new species of Actinomadura: taxonomy of the producing culture, fermentation, physico-chemical and biological properties of the antibiotic.
The novel chlorine-containing acidic polycyclic ether antibiotic CP-54,883 (C41H62O12Cl2) [corrected] is produced by the fermentation of Actinomadura routienii Huang sp. nov. This report presents the taxonomy and the fermentation conditions for the antibiotic-producing culture. The antibiotic is mainly active against Gram-positive bacteria. It protects chickens against Eimeria challenge in vivo and enhances rumen propionic acid in vitro. The physico-chemical properties are also characterized.
Cullen
W P
WP
Central Research, Pfizer Inc., Groton, Connecticut 06340.
Celmer
W D
WD
Chappel
L R
LR
Huang
L H
LH
Maeda
H
H
Nishiyama
S
S
Shibakawa
R
R
Tone
J
J
Watts
P C
PC
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000302:isolation & purification* / Q000627:therapeutic use; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy; D004987:Ethers; D007476:Ionophores; D008826:Microbial Sensitivity Tests; D011714:Pyrans / Q000032:analysis / Q000302:isolation & purification / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D004987:Ethers; D007476:Ionophores; D011714:Pyrans; C054472:CP 54883