Kinetics of 8-methoxypsoralen and 5-methoxypsoralen distribution in guinea pig serum, epidermis and ocular lens.
The kinetics of 8-methoxypsoralen (8-MOP) and 5-methoxypsoralen (5-MOP) distribution in serum, epidermis and lens was studied in the guinea pig following oral administration of crystalline 8-MOP or 5-MOP. Serum and epidermal levels of both psoralens, determined by high performance liquid chromatography, showed similar uptake and elimination. Lens levels of 8-MOP significantly lagged behind serum and epidermal levels. There were measurable quantities of 8-MOP in both epidermis and lens 18 h following administration. The bioavailability of 5-MOP was significantly lower than that of 8-MOP in all tissues analyzed. Possible clinical significance of these findings is discussed.
Division of Toxicology, Food and Drug Administration, Washington, DC.
W
W
Wamer
A
A
Giles
A
A
Kornhauser
D000078223:5-Methoxypsoralen; D000818:Animals; D004817:Epidermis / Q000378:metabolism*; D006168:Guinea Pigs; D007908:Lens, Crystalline / Q000378:metabolism*; D008730:Methoxsalen / Q000097:blood / Q000493:pharmacokinetics*
D000078223:5-Methoxypsoralen; D008730:Methoxsalen