[Benzoxazolinone phenylethanolamine antagonists of adrenergic receptors. A chemical and pharmacodynamic study].
Benzoxazolinone can be considered as a bioisosteric analogue of pyrocatechol. This concept has led to the synthesis of benzoxazolinonic phenylethanolamines. The pharmacological study shows that these compounds possess an affinity for adrenergic receptors. Compound (XXXIV), the most interesting, is a competitive alpha and beta adrenergic antagonist which has been studied for antihypertensive activity.
Vaccher
M P
MP
Lesieur
D
D
Lespagnol
C
C
Bonte
J P
JP
Lamar
J C
JC
Beaughard
M
M
Dureng
G
G
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D004983:Ethanolamines / Q000138:chemical synthesis* / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D010627:Phenethylamines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013565:Sympatholytics / Q000138:chemical synthesis*
D000959:Antihypertensive Agents; D004983:Ethanolamines; D010080:Oxazoles; D010627:Phenethylamines; D013565:Sympatholytics
Phényléthanolamines benzoxazolinoniques antagonistes des récepteurs adrénergiques. Etude chimique et pharmacodynamique.