A simple method for the production of ventricular tachycardia in the rat and guinea pig.
A simple method for the production of ventricular tachycardia in the rat and guinea pig was developed. The animals were made to inhale benzene vapors for 2 min. An intravenous injection of adrenaline was given during the last 30 sec of benzene administration. Ventricular tachycardia developed in 95% of the animals used. Development of ventricular tachycardia in guinea pigs was earlier than in rats, but the duration of the ventricular tachycardia was almost equal in both species of animals. The arrhythmia developed by this method is of short duration, reliable, and reproducible. This method can be utilized for the rapid screening of antiarrhythmic agents.
R M
RM
Tripathi
G P
GP
Thomas
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001554:Benzene / Q000008:administration & dosage; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004837:Epinephrine / Q000008:administration & dosage; D006168:Guinea Pigs; D051381:Rats; D011919:Rats, Inbred Strains; D013610:Tachycardia / Q000139:chemically induced / Q000188:drug therapy
D000889:Anti-Arrhythmia Agents; D001554:Benzene; D004837:Epinephrine