[Therapy of peptic ulcer and chronic gastritis with bismuth salts].
Colloidal bismuth subcitrate (CBS) precipitates in an acid environment, adheres to mucus, blocks pepsin activity, retards hydrogen-ion back diffusion and stimulates prostaglandin synthesis. The average healing rate after 4 weeks' treatment with CBS is 78% in duodenal ulcer versus 67% with cimetidine. A direct comparison with ranitidine gives healing rates of 78% (CBS) as opposed to 78% with ranitidine. The corresponding figures in gastric ulcer are 68% (CBS) and 54% (cimetidine). The percentage of relapse-free patients is substantially higher after CBS ulcer healing than after H2-blockers. Bismuth subsalicylate eliminates Campylobacter pylori in 71% after 4-weeks' therapy. Parallel to this elimination a decrease and normalization of the acute inflammatory process can be seen in antral mucosa.
Medizinische Klinik am Nordwest-Krankenhaus Frankfurt am Main.
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D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001729:Bismuth; D002169:Campylobacter Infections / Q000188:drug therapy*; D002908:Chronic Disease; D004381:Duodenal Ulcer / Q000188:drug therapy; D005756:Gastritis / Q000188:drug therapy*; D006801:Humans; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010437:Peptic Ulcer / Q000188:drug therapy*; D012459:Salicylates / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000188:drug therapy
D000897:Anti-Ulcer Agents; D009942:Organometallic Compounds; D012459:Salicylates; C015715:bismuth subsalicylate; C002791:bismuth tripotassium dicitrate; D001729:Bismuth
Therapie des peptischen Ulkus und der chronischen Gastritis mit Wismutsalzen.