Nicotinic acetylcholine binding sites in Alzheimer's disease.
In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy from patients with AD and from matched controls. A consistent and severe loss of nicotinic receptors was found in AD.
P J
PJ
Whitehouse
A M
AM
Martino
P G
PG
Antuono
P R
PR
Lowenstein
J T
JT
Coyle
D L
DL
Price
K J
KJ
Kellar
D000109:Acetylcholine / Q000378:metabolism; D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism*; D002540:Cerebral Cortex / Q000032:analysis* / Q000201:enzymology / Q000378:metabolism; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D006801:Humans; D009538:Nicotine / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000032:analysis*
D011978:Receptors, Nicotinic; D009538:Nicotine; D002795:Choline O-Acetyltransferase; D000109:Acetylcholine