The interaction of complement components with Aeromonas species.
The interaction of seven serum-sensitive Aeromonas strains with the complement system was investigated using a 2-h quantitative assay. Of the strains tested, four isolates activated both the alternative and classical pathways, two activated only the alternative pathway, and one strain was sensitive to the bactericidal action of complement through the classical pathway only. Two of the four Aeromonas caviae strains were such efficient activators of the complement system that when challenged with human sera deficient in normal concentrations of C3 and C4, they were still subject to complement-mediated bacterial lysis. This phenomenon, in conjunction with previous studies on complement activation by Aeromonas spp., may help account for the decreased incidence observed of systemic disease caused by Aeromonas caviae.
Brenden
R A
RA
Janda
J M
JM
D000333:Aeromonas / Q000276:immunology* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D001770:Blood Bactericidal Activity; D003167:Complement Activation; D003176:Complement C3 / Q000172:deficiency; D003181:Complement C4 / Q000172:deficiency; D003170:Complement Pathway, Alternative; D003171:Complement Pathway, Classical; D004546:Elapid Venoms / Q000494:pharmacology; D006801:Humans; D009113:Muramidase / Q000378:metabolism
D003176:Complement C3; D003181:Complement C4; D004546:Elapid Venoms; C016310:cobra venom factor; D009113:Muramidase