Prevention of endotoxaemia by non-absorbable antibiotics in heat stress.
Four anaesthetised monkeys were given oral kanamycin (15 mg 1 kg 12 hourly) over five consecutive days before being heat stressed. Four other anaesthetised monkeys served as controls. The plasma lipopolysaccharide concentration in control primates increased initially from 0.044 (SEM 0.004) ng/ml to 0.062 (0.006) ng/ml as the rectal temperature increased from 37.5 to 39.5 degrees C. A second increase in lipopolysaccharides started at 42 degrees C and reached 0.308 (0.038) ng/ml (p less than 0.01) at 44.5 degrees C. Before heat stress the plasma lipopolysaccharide concentration in the primates who had been pretreated with kanamycin was 0.007 (0.006) ng/ml, and despite heating these animals to 44.5 degrees C no increase in plasma lipopolysaccharide concentrations were seen in this group. The cardiovascular variable during heat stress were more unstable in the control group and began to deteriorate at a lower temperature than in the group receiving antibiotic. These data suggest that the increased plasma lipopolysaccharide concentration during heat stress originates mainly from the gut.
Gathiram
P
P
Department of Physiology, University of Durban-Westville, South Africa.
Wells
M T
MT
Brock-Utne
J G
JG
Wessels
B C
BC
Gaffin
S L
SL
D000818:Animals; D001794:Blood Pressure; D001831:Body Temperature; D002522:Chlorocebus aethiops; D004731:Endotoxins / Q000097:blood; D005260:Female; D006339:Heart Rate; D006359:Heat Exhaustion / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D007612:Kanamycin / Q000627:therapeutic use*; D008070:Lipopolysaccharides / Q000097:blood*; D008297:Male; D014115:Toxemia / Q000517:prevention & control*
D004731:Endotoxins; D008070:Lipopolysaccharides; D007612:Kanamycin