The effect of selective and non-selective cholinergic blockade on bombesin- and peptone-stimulated gastrin release.
We have studied the effects of the selective muscarinic M1-receptor antagonist pirenzepine and the non-selective muscarinic antagonist atropine on bombesin- and peptone-stimulated gastrin release in healthy subjects. Pirenzepine (i. v. bolus 0.6 mg/kg) and atropine (i. v. bolus 15 micrograms/kg, followed by an infusion of 5 micrograms.kg-1.h-1) were given in doses equipotent in terms of reduction of gastric acid secretion. Neither affected bombesin- or peptone-stimulated gastrin release. These findings do not support the involvement of M1-receptors in the cholinergic regulation of gastrin release and suggest that the reduction in acid secretion caused by pirenzepine is not mediated by inhibition of gastrin release.
Department of Gastroenterology, University Hospital, Groningen, The Netherlands.
J H
JH
Kleibeuker
C B
CB
Lamers
D000328:Adult; D001285:Atropine / Q000494:pharmacology; D001839:Bombesin / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D010461:Peptones / Q000494:pharmacology*
D005755:Gastrins; D010276:Parasympatholytics; D010461:Peptones; D001285:Atropine; D001839:Bombesin