Effects of the organophosphorus compound, O-ethyl-N-dimethyl-phosphoramidocyanidate (tabun), on flavor aversions, locomotor activity, and rotarod performance in rats.
An assessment of the behavioral effects of acutely administered anti-cholinesterase compound O-ethyl-N-dimethyl phosphoramidocyanidate (tabun), to male rats was performed in three studies across five dose levels (100-198 micrograms/kg, sc). Doses of 122 micrograms/kg or greater produced conditioned flavor aversions. Spontaneous locomotor activity was significantly decreased at doses of 122 micrograms/kg or greater when compared to vehicle control levels. When administered doses of 168 micrograms/kg or greater, rats exhibited significant decrements in rotarod performance. In addition, the LD50 of tabun was determined to be 240 micrograms/kg. Signs of cholinergic intoxication were not apparent until 144 micrograms/kg tabun or more were given. Behavioral effects were thus obtained at doses that were between 54 and 71% of the LD50.
Romano
J A
JA
Landauer
M R
MR
D000818:Animals; D002800:Cholinesterase Inhibitors; D003216:Conditioning, Operant / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010755:Organophosphates; D004856:Postural Balance / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000187:drug effects*
D002800:Cholinesterase Inhibitors; D010755:Organophosphates; C009374:tabun