High levels of IgA-containing circulating immune complex and secretory IgA in Kawasaki disease.
Sera of patients with Kawasaki disease were studied for the levels of IgA-containing (C3-fixing) circulating immune complexes (IgA-CIC), IgG-containing (IgG-)CIC, total IgA, secretory IgA, and complement component (C3) by means of enzyme-linked immunosorbent assays or single radial immunodiffusion methods. There was significantly high level of IgA-CIC, but not IgG-CIC. The levels of total IgA, secretory IgA, and C3 were significantly elevated. Significantly high levels of secretory IgA were found in 22 (51%) of 43 patients. The proportion of secretory IgA to total IgA also increased. These abnormalities in the IgA system may play a role in Kawasaki disease.
Department of Pathology, Faculty of Medicine, Kyoto University.
G
G
Ohshio
F
F
Furukawa
M
M
Khine
H
H
Yoshioka
H
H
Kudo
Y
Y
Hamashima
D000936:Antigen-Antibody Complex / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000378:metabolism; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D007074:Immunoglobulin G / Q000378:metabolism; D007223:Infant; D009080:Mucocutaneous Lymph Node Syndrome / Q000276:immunology*
D000936:Antigen-Antibody Complex; D003176:Complement C3; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G