[Congenital disorders of tyrosine metabolism and their correction in children with tumors].
The paper deals with the evaluation of quantitative indexes of urine excretion of tyrosine and its metabolites--highly carcinogenic p-hydroxyphenyllactic acid and homogentisic acid--in infants suffering various tumors and their parents. Also, the effect of ascorbic acid (100 mg/kg body weight daily) on tyrosine metabolism was studied. The sick children and their parents showed increased urine excretion of tyrosine and p-hydroxyphenyllactic acid matched by a decrease in that of homogentisic acid. The said changes suggest inhibition of p-hydroxyphenylpyruvate dioxygenase (CE 1.13.11.27). High doses of ascorbic acid were shown to arrest or significantly inhibit the excretion of carcinogenic metabolite of tyrosine in patients with hemoblastoses and nephroblastoma.
V N
VN
Baĭkova
I M
IM
Vares
V G
VG
Rybal'chenko
V E
VE
Shevchenko
E N
EN
Sotnikova
D000293:Adolescent; D000328:Adult; D000592:Amino Acid Metabolism, Inborn Errors / Q000150:complications / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006713:Homogentisic Acid / Q000652:urine; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange; D009369:Neoplasms / Q000151:congenital* / Q000652:urine; D010666:Phenylpropionates / Q000652:urine; D011247:Pregnancy; D014443:Tyrosine / Q000652:urine*
D010666:Phenylpropionates; C001418:4-hydroxyphenyllactic acid; D014443:Tyrosine; D006713:Homogentisic Acid
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