New approach to automated synthesis of oligoribonucleotides.
The combination of 2'-OH protection in ribonucleosides by the p-nitrophenylethylsulfonyl (NPES) group with the 3'-(beta-cyanoethyl) (N,N-diisopropyl)-phosphoramidite function reveals a new approach to oligoribonucleotide synthesis. The corresponding adenosine and guanosine derivatives have been applied to automated solid phase synthesis with good success.
Fakultät für Chemie, Universität Konstanz, FRG.
H
H
Schirmeister
R
R
Charubala
B S
BS
Schulz
W
W
Pfleiderer
D000241:Adenosine; D006151:Guanosine; D007202:Indicators and Reagents; D009843:Oligoribonucleotides / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D009843:Oligoribonucleotides; D006151:Guanosine; D000241:Adenosine