[Changes in slow evoked potentials in depressed patients treated with amitriptyline and oxaprotiline].
Using a simple S1S2-R paradigm, acoustically evoked potentials, CNV, and PINV were recorded in 59 patients with major depressive disorder before and during a 4 week double blind pharmacological treatment with either amitriptyline (AT) or oxaprotiline (OT). In parallel, 30 healthy subjects were investigated 3 times, in identical intervals of 2 weeks. In the depressed state patients exhibited significantly smaller CNVs than the controls. In the AT-group clinical improvement and drug plasma levels of nortriptyline (NT, the principal metabolite of AT and an active antidepressant by itself) were positively related to increases in CNV-area; in the OT-group the reverse was true: increase in CNV-area was related to smaller OT plasma levels and less favourable outcome. The control group displayed a steady decline in CNV area during the 3 test sessions. N1P2 amplitude and PINV were not significantly different between groups and exhibited only minor variations during treatment.
Universitäts Nervenklinik, Tübingen, RFA.
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Giedke
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Heimann
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Rein
D000328:Adult; D000639:Amitriptyline / Q000097:blood / Q000627:therapeutic use*; D000873:Anthracenes / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000097:blood / Q000627:therapeutic use*; D003265:Contingent Negative Variation / Q000187:drug effects*; D003866:Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D004594:Electrophysiology / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000031:analogs & derivatives / Q000097:blood / Q000627:therapeutic use*; D008875:Middle Aged; D009661:Nortriptyline / Q000097:blood; D011897:Random Allocation
D000873:Anthracenes; D000928:Antidepressive Agents; D000639:Amitriptyline; D008376:Maprotiline; C027299:hydroxymaprotilin; D009661:Nortriptyline
La modification des potentiels évoqués lents chez les déprimés sous amitriptyline et oxaprotiline.