CNS oxygen toxicity in the rat: role of ambient illumination.
The effect of ambient illumination on sensitivity to CNS oxygen toxicity was studied in awake male rats. Continuous recording of the EEG was obtained with chronically implanted cortical electrodes. The appearance of the electrical discharges in the EEG was used as an end point for CNS oxygen toxicity. It was found that sensitivity to CNS oxygen toxicity was inversely related to the level of ambient light illumination. The latent period for appearance of the electrical discharges was significantly shorter in darkness than in light over most of the oxygen pressures. Rats with severely depressed retinal function were as sensitive to oxygen at high pressure as normal rats in darkness, demonstrating the importance of visual input in the modulation of sensitivity to CNS oxygen toxicity.
N
N
Bitterman
Y
Y
Melamed
I
I
Perlman
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects* / Q000473:pathology; D003624:Darkness; D004596:Electroretinography; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008027:Light; D008297:Male; D010100:Oxygen / Q000633:toxicity*; D051381:Rats; D012160:Retina / Q000473:pathology; D014851:Wakefulness
D010100:Oxygen