[Effect of various cations on the secretory and acid-forming function of the stomach].
The data obtained suggest that the sodium ions (0.5-2.0 g) reduce the gastric juice secretion and its acidity whereas magnesium and calcium ions increase the latter. Potassium ions exert practically no effect on the acidity. The suppressing effect of the sodium ions seems to be connected with an increase excretion of sodium chloride with urine as well as with increased diuresis in general. Saluretics suppress the secretion and acidity of the gastric juice on account of increased diuresis and subsequent excretion of large amount of chlorides as well as by means of serotonin release from the Ec cells of the gastro-intestinal tract, the action of serotonin being actualized on the level of the gastric glands' cells, parietal those in particular.
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Bakuradze
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002412:Cations / Q000494:pharmacology*; D002417:Cattle; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D008274:Magnesium / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology
D002412:Cations; D012701:Serotonin; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium
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