[Microvalves in microvenules].
A long-lasting histological study on muscle and cutaneous-subcutaneous biopsies allowed certain observations of microvalves in venules with a diameter ranging from 80 to 200 micron. Venular leaflets originate from the vein as extroflection of the intima, made by a single layer of endothelial cells. In the patient affected by severe chronic venous insufficiency the valvular leaflets appear thickened while the wall of the venule presents sclero-hyalinotic alterations. The presence of microvalves in venules suggests a role of their incontinence in the venous insufficiency. Considering that the venular leaflets are made just by endothelial cells, a primary pathogenetic role has to be achieved to the endotheliopathy in the genesis of venous insufficiency.
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Clinica Chirurgica III, Università di Milano, Ospedale Policlinico.
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D002908:Chronic Disease; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008833:Microcirculation; D014689:Venous Insufficiency / Q000473:pathology*; D014699:Venules / Q000473:pathology
Les microvalvules dans les microveinules.