Cryptococcal pneumonia in a patient with sickle cell disease.
We present the findings in a patient having sickle cell disease who developed multilobar pneumonia. Cultures of bronchial aspirates and histologic specimens grew Cryptococcus neoformans. There was neither spontaneous clearing of the infection nor a response to bactericidal antibiotics. The patient had no underlying malignant neoplasm or immunodeficiency as indicated by history, physical examination, and specialized tests of humoral and cell-mediated immunity.
R E
RE
Hardy
C
C
Cummings
F
F
Thomas
D
D
Harrison
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000755:Anemia, Sickle Cell / Q000150:complications*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003453:Cryptococcosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D011014:Pneumonia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D011859:Radiography
D000900:Anti-Bacterial Agents; D000666:Amphotericin B