Comparisons between CK-B and other clinical indicators of cardiac contusion following multiple trauma.
The activity of creatine kinase (CK) and creatine kinase B(CK-B) was measured in 17 patients with injuries to multiple organ systems, including the chest. The patients were closely observed for clinical signs of disturbed cardiac function by means of serial ECG, continuous monitoring of cardiac rhythm, daily cardiac auscultation, serial chest roentgenography and monitoring of central hemodynamic parameters. No statistically significant difference in CK and CK-B activity was found between the group of patients with normal cardiac function and the group with disturbed cardiac function. The CK-B activity was markedly elevated, but CK-B activity relative to CK activity was normal in both groups during the first 7 days after the trauma. The authors conclude that the significance of these enzymes' serum activity, measured with the immunoinhibition method, is diagnostically doubtful not only as regards cardiac contusions, but also in other cardiopathy preceding or following major trauma.
Andersen
P T
PT
Møller-Petersen
J
J
Nielsen
L K
LK
Mølgaard
J
J
D000007:Abdominal Injuries / Q000150:complications; D000328:Adult; D001842:Bone and Bones / Q000293:injuries; D001930:Brain Injuries / Q000150:complications; D003402:Creatine Kinase / Q000097:blood*; D004562:Electrocardiography; D005260:Female; D006326:Heart Auscultation; D006335:Heart Injuries / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D013898:Thoracic Injuries / Q000150:complications; D014949:Wounds, Nonpenetrating / Q000175:diagnosis*
D007527:Isoenzymes; D003402:Creatine Kinase