A variable reabsorption time-delay model for pharmacokinetics of drugs.
A two-compartment model with time delay is proposed to describe the pharmacokinetics of drugs subject to enterohepatic circulation. This model is applicable when the reabsorption is repeated several times at unequal intervals. Sample applications are provided.
Laboratoire de biophysique et de biomathématique, Toulouse, France.
C
C
Labat
K
K
Mansour
M F
MF
Malmary
M
M
Terrissol
J
J
Oustrin
D001659:Biliary Tract / Q000378:metabolism*; D004764:Enterohepatic Circulation; D007408:Intestinal Absorption; D008433:Mathematics; D008954:Models, Biological; D010599:Pharmacokinetics; D013997:Time Factors