[Effect of myelopeptides on the synthesis of DNA and total protein in the cells of the lymphoid organs in the mouse].
Using double 3H-thymidine/14C-amino acid label, the influence of myelopeptides (MP) on chromosomal DNA and total protein (without histones) synthesis has been studied in vitro in mouse lymphoid organ cells. It has been shown that MP cause a decrease in DNA labelling and a parallel increase in protein labelling in bone marrow cells and have practically no effect on these two parameters in thymus, lymph node and spleen cells. It has been found that MP have only mitogenic effect on the above-mentioned organ cells, but in combination with 2-mercaptoethanol. The data obtained show that MP possess the properties of cell-differentiating factors.
Strelkov
L A
LA
Stepanenko
R N
RN
Mikhaĭlova
A A
AA
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism*; D002454:Cell Differentiation / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis*; D008623:Mercaptoethanol / Q000494:pharmacology; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009842:Oligopeptides; D010455:Peptides / Q000494:pharmacology*; D014176:Protein Biosynthesis; D013154:Spleen / Q000187:drug effects / Q000378:metabolism*
D009842:Oligopeptides; D010455:Peptides; C048617:myelopeptides; D008623:Mercaptoethanol; D004247:DNA
Izuchenie deĭstviia mielopeptidov na sintez DNK i summarnogo belka v kletkakh limfoidnykh organov myshi