Ceftriaxone pharmacokinetics following multiple intramuscular dosing.
The steady-state pharmacokinetics and tolerance of ceftriaxone after multiple i.m. doses of 0.5 and 1 g q12 h for 3.5 days were investigated in 12 healthy, adult volunteers. Ceftriaxone was rapidly absorbed after i.m. administration with mean peak times ranging from 1.3 to 1.9 h. Steady-state plasma concentrations were apparent after the third dose of both dosage regimens, with trough plasma concentrations of 24 +/- 6 and 39 +/- 8 micrograms/ml (mean +/- SD) after the 0.5 and 1 g q12 h regimens, respectively. Multiple i.m. administrations of ceftriaxone did not alter its elimination half-life; however, small increases were observed in the plasma clearance and volume of distribution at the 1-g regimen. These increases were attributed to the non-linear binding of ceftriaxone to human plasma proteins, and are therapeutically unimportant. Ceftriaxone was well tolerated and serious or lasting adverse reactions were not encountered in the study.
A A
AA
Holazo
I H
IH
Patel
R E
RE
Weinfeld
J J
JJ
Konikoff
M
M
Parsonnet
D000328:Adult; D002443:Ceftriaxone / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007509:Irritants; D007700:Kinetics; D008297:Male
D007509:Irritants; D002443:Ceftriaxone; D003402:Creatine Kinase