Comparison of intramuscular buprenorphine and a buprenorphine/naloxone combination in the treatment of post-operative pain.
The analgesic efficacy and tolerance of a single intramuscular injection of either buprenorphine (0.3 mg) or a buprenorphine (0.3 mg)/naloxone (0.2 mg) combination was compared in 70 patients suffering from moderate to severe pain after abdominal surgery. Patients in both treatment groups experienced good analgesia which was apparent within 10 minutes of administration and lasted for approximately 12 hours. The most frequently reported unwanted effects were drowsiness and/or sleepiness and nausea and/or vomiting which were of mild or moderate severity in most cases. No significant differences were seen between the two treatment groups with regard to the overall assessments of efficacy and tolerance.
Vanacker
B
B
Vandermeersch
E
E
Tomassen
J
J
D000328:Adult; D000368:Aged; D002047:Buprenorphine / Q000008:administration & dosage* / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009019:Morphinans / Q000008:administration & dosage*; D009270:Naloxone / Q000008:administration & dosage* / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*
D004338:Drug Combinations; D009019:Morphinans; D009270:Naloxone; D002047:Buprenorphine