Structural studies on rhodilunancins A and B.
Antitumor antibiotics rhodilunancins A and B were isolated from a culture of Streptomyces violaceus var. lunanensis var. n. No. 1289 by acidic acetone extraction of mycelia and purified by silica gel chromatography. Rhodilunancin A is identical to cosmomycin A. Rhodilunancin B is identical to cosmomycin B (= rhodomycin Y). Both antibiotics exhibited activities against Gram-positive bacteria and inhibition on DNA synthesis of P388 leukemia cell in vitro.
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D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009279:Naphthacenes / Q000302:isolation & purification / Q000494:pharmacology
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; C053961:cosmomycin B; C048658:rhodilunancin A