The effect of oestradiolum benzoicum and progesterone on the noradrenalin content in organs of the female reproductive system of sexually immature pigs.
The paper describes the effect of exogenous oestradiol and progesterone on noradrenalin (NA) content in the ovary, tuba uterina, uterus, and vagina, and on the morphological features of adrenergic nerves in these organs in sexually immature female pigs. 30 animals were used, of body weight 37 to 43 kg, and age 115 to 125 d. The animals were divided randomly into 4 groups. Group I (n = 6) constituted the control, group II (n = 8) was given oestradiolum benzoicum, group III (n = 8) was given progesterone, and group IV (n = 8) was given oestradiol and progesterone. Oestradiol injections resulted in a 1.5-fold increase of NA content in the ovary, a 4.5-fold increase in the tuba uterina, and a decrease of NA content in the uterine horn, cervix, and in the vagina, to 0.6 of the control NA level. Progesterone injections did not cause changes in NA content in the ovary, while there was 8.5-fold increase of NA in the oviduct, a 4-fold increase in the uterile horn, a 6-fold increase in the cervix, and a 3-fold increase in the vagina compared to the control. Joint injections of oestradiol and progesterone resulted in a decrease of NA content in the ovary to about 0.5 of the control level, and in an increase of NA content of about 5-fold in the tuba uterina, 7-fold in the uterine horn, 8-fold in the cervix, and 2-fold in the vagina. The increase of NA content in the organs was coupled with a slight increase in the density of the adrenergic innervation and the intensity of fluorescence of these nerves compared to the control. The results were compared to the results of similar but not identical studies, carried out on other mammals.
M
M
Lakomy
J
J
Kotwica
J
J
Całka
J
J
Kaleczyc
D000320:Adrenergic Fibers / Q000187:drug effects*; D000818:Animals; D002584:Cervix Uteri / Q000294:innervation; D004958:Estradiol / Q000494:pharmacology*; D005187:Fallopian Tubes / Q000294:innervation; D005260:Female; D005836:Genitalia, Female / Q000294:innervation*; D008856:Microscopy, Fluorescence; D009474:Neurons / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism*; D010053:Ovary / Q000294:innervation; D011374:Progesterone / Q000494:pharmacology*; D012741:Sexual Maturation / Q000187:drug effects*; D013552:Swine; D014599:Uterus / Q000294:innervation; D014621:Vagina / Q000294:innervation
D011374:Progesterone; D004958:Estradiol; D009638:Norepinephrine