Attentional and perseverative impairment in two cases of familial fatal parkinsonism with cortical sparing.
The neuropsychological findings in twin brothers with familial fatal Parkinsonism are reported. Post-mortem examination had shown extensive pathology in basal ganglia and brainstem, but not in the cerebral cortex. Although both showed average intelligence three months prior to death, they had impairment on a sorting task and in serial attention span. Some possible neural mechanisms are discussed.
Kimura
D
D
Department of Psychology, University of Western Ontario, London, Canada.
Hahn
A
A
Barnett
H J
HJ
D001288:Attention / Q000502:physiology*; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D004193:Discrimination Learning / Q000502:physiology; D004200:Diseases in Twins; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000235:genetics* / Q000473:pathology; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000235:genetics* / Q000473:pathology; D012131:Respiratory Insufficiency / Q000235:genetics / Q000473:pathology