[Determination of benzopyrene-hydroxylase (cytochrome P-450) activity in patients with lung cancer].
The study was concerned with comparison of inducibility index (ii) for benzopyrene-hydroxylase in mitogen-activated lymphocytes in patients with primary cancer of the lung, other cancers (breast, stomach, lower lip, rectum, skin and thyroid gland) and in lymphocytes of blood donors. The highest ii values were registered in bronchogenic carcinoma patients. Smokers, both lung cancer patients and healthy donors, revealed high values (80.0 and 83.3%, respectively). A modified "lymphocytic test" to assess the risk factor for primary lung cancer is suggested.
Ostashevskiĭ
V A
VA
Narov
Iu E
IuE
D000328:Adult; D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis*; D001579:Benzopyrene Hydroxylase / Q000096:biosynthesis*; D002283:Carcinoma, Bronchogenic / Q000201:enzymology* / Q000209:etiology; D004790:Enzyme Induction; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000209:etiology; D008214:Lymphocytes / Q000201:enzymology; D008875:Middle Aged; D012307:Risk Factors
D001579:Benzopyrene Hydroxylase; D001189:Aryl Hydrocarbon Hydroxylases
Opredelenie aktivnosti fermenta benzpiren-gidroksilazy (tsitokhrom P-450) u bol'nykh rakom legkogo.