Denervation increases myogenic tone in a resistance artery in the growing rabbit ear.
The effect of chronic sympathetic and sensory denervation of the growing rabbit ear vasculature on myogenic tone in a resistance artery was studied. Unilateral superior cervical ganglionectomy and section of greater and anterior auricular nerves were performed at 4 wk of age. Compared with the contralateral control, 2 and 6 wk later, the denervated artery developed greater stretch-dependent myogenic tone. This phenomenon may partially account for the return of tone described in the denervated ear vasculature.
Mangiarua
E I
EI
Joyce
E H
EH
Bevan
R D
RD
D000818:Animals; D001158:Arteries / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology; D004423:Ear / Q000098:blood supply* / Q000254:growth & development; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D011817:Rabbits; D013562:Sympathectomy; D014655:Vascular Resistance
D010208:Papaverine; D009638:Norepinephrine