Lactic acidosis during closed-chest CPR in dogs.
Survival after out-of-hospital cardiac arrest is intimately related to the time from cardiovascular collapse to the initiation of CPR, or downtime. Furthermore, the reperfusion technique that optimizes coronary and cerebral blood flow after cardiac arrest may also be dependent on downtime. Peak blood lactate levels have been shown to be unchanged throughout resuscitation and predictive of downtime in dogs subjected to cardiopulmonary arrest and open cardiac massage. The purpose of this study was to determine the course of arterial lactate levels in dogs subjected to a fibrillatory cardiopulmonary arrest and conventional closed-chest CPR (CCPR). Fourteen dogs were subjected to five minutes of cardiopulmonary arrest and 30 minutes of CCPR. Resuscitation was performed according to a standardized protocol. Arterial lactic acid samples were collected at timed intervals throughout the experiment. Mean arterial lactic acid levels increased significantly with each sampling interval during 30 minutes of CCPR (overall P less than .05). In nine dogs successfully resuscitated, there were no significant differences in mean arterial lactic acid levels after the return of spontaneous circulation (ROSC). Open-chest resuscitation after five minutes of ventricular fibrillation in dogs results in peak lactic acid levels that do not change significantly once internal cardiac massage is initiated. In contrast, CCPR in similarly arrested dogs does not appear to provide adequate tissue oxygenation and/or perfusion to prevent continuous lactic acid accumulation.
Department of Emergency Medicine, Henry Ford Hospital, Detroit, Michigan 48202.
D L
DL
Carden
G B
GB
Martin
R M
RM
Nowak
C C
CC
Foreback
M C
MC
Tomlanovich
D000140:Acidosis, Lactic / Q000097:blood*; D000818:Animals; D001158:Arteries; D001794:Blood Pressure; D004285:Dogs; D004554:Electric Countershock; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D012151:Resuscitation; D014693:Ventricular Fibrillation / Q000503:physiopathology / Q000628:therapy
D007773:Lactates; D019344:Lactic Acid