Intratumoral measurement and plasma pharmacokinetics of intravenously administered melphalan. Report of a patient with plasmacytoma.
In a human case of plasmacytoma we studied plasma and tumor concentrations of melphalan given intravenously. Intratumoral concentration of melphalan was similar to plasma concentration 60 min after the end of infusion.
Friberg
S
S
Department of General Oncology, Danderyd's Hospital, Sweden.
Ehrsson
H
H
Eksborg
S
S
Carenfeldt
C
C
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008558:Melphalan / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D010610:Pharyngeal Neoplasms / Q000378:metabolism*; D010954:Plasmacytoma / Q000188:drug therapy / Q000378:metabolism*; D011239:Prednisolone / Q000008:administration & dosage
D011239:Prednisolone; D008558:Melphalan