Endogenous hypertriglyceridemia in a nonobese rat model: plasma lipoproteins and dietary sensitivity.
Sprague-Dawley male rats from the Ivanovas-Sieve colony (IVA-SIV) show higher plasma triglyceride levels compared to the standard Charles River (CR) rats. The triglyceride enrichment occurs primarily in the very-low-density lipoproteins (VLDL), otherwise of a normal % composition, suggesting that the number of particles is increased, rather than their triglyceride (TG) content. High-density lipoprotein (HDL) particles, corresponding to HDL1, appear to be increased in the IVA-SIV rats, as confirmed by rate-zonal ultracentrifugation. The apoprotein composition of isolated lipoproteins (apo B content and isoelectric focusing pattern), does not differ in the two strains. The IVA-SIV rats are remarkably more TG inducible, compared to the standard CR. This can be shown with fructose loading and with a cholesterol-cholic acid diet. The plasma TG increase, after Triton administration, indicative of the VLDL-TG production, is fourfold higher in the IVA-SIV, compared to the CR rats. These findings provide evidence for some similarities between the IVA-SIV rat and human endogenous hypertriglyceridemia, and suggest an increased TG biosynthesis in this model.
M R
MR
Lovati
G
G
Franceschini
L
L
Allievi
E
E
Dall'Aglio
I
I
Zavaroni
C R
CR
Sirtori
D000818:Animals; D001835:Body Weight; D002501:Centrifugation, Zonal; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D019826:Cholic Acid; D002793:Cholic Acids / Q000008:administration & dosage; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004195:Disease Models, Animal; D005632:Fructose / Q000008:administration & dosage; D006953:Hyperlipoproteinemia Type IV / Q000097:blood / Q000662:veterinary*; D007525:Isoelectric Focusing; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains / Q000097:blood*; D012376:Rodent Diseases / Q000097:blood
D002791:Cholesterol, Dietary; D002793:Cholic Acids; D004040:Dietary Carbohydrates; D008055:Lipids; D008074:Lipoproteins; D005632:Fructose; D011092:Polyethylene Glycols; D019826:Cholic Acid