Synthesis and cloning of a human beta-casomorphin-5 gene.
As so far a singularity among opioid peptides, bovine beta-casomorphin-5 has been shown to display pronounced cardiatic activities. The gene sequence of a human beta-casomorphin-5, including plasmid insertion and fusion protein expression and cleavage instrumentary, has been synthesized by a manual phosphoramidite procedure and cloned in a bacterial system.
Martin Luther University, Department of Chemistry, Halle/S, GDR.
S
S
Hoffmann
E
E
Günther
G
G
Kunze
D
D
Bärwolff
M
M
Teppke
A
A
Barth
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002364:Caseins / Q000235:genetics*; D002417:Cattle; D003001:Cloning, Molecular; D004247:DNA / Q000138:chemical synthesis* / Q000235:genetics; D004723:Endorphins / Q000235:genetics*; D005796:Genes; D005813:Genes, Synthetic; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation
D002364:Caseins; D004723:Endorphins; C021968:beta-casomorphins; D004247:DNA