Hereditary protein C deficiency during pregnancy.
Hereditary protein C, a primary hypercoagulable state, has not been previously associated with preeclamptic toxemia. A woman with previous preeclamptic toxemia and fetal deaths presented with recurrent deep vein thrombosis during her third pregnancy. Hereditary protein C was diagnosed but full heparinization followed by low-dose heparin failed to prevent preeclamptic toxemia.
Institute of Hematology, Ichilov Hospital, Tel-Aviv, Israel.
B
B
Brenner
A
A
Shapira
C
C
Bahari
L
L
Haimovich
U
U
Seligsohn
D000328:Adult; D005260:Female; D006801:Humans; D010375:Pedigree; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000235:genetics*; D011250:Pregnancy Complications, Hematologic / Q000235:genetics*; D020151:Protein C Deficiency; D012008:Recurrence; D013927:Thrombosis / Q000235:genetics*