Hygromycin A, an antitreponemal substance. II. Therapeutic effect for swine dysentery.
This study was conducted to evaluate hygromycin A fed to growing swine at 1, 5, 10 or 20 g/ton feed for the control of Treponema hyodysenteriae-caused dysentery. Pigs provided carbadox at 50 g/ton feed served as an infected treatment control group. All pigs were orally, via stomach intubation, administered 100 ml of a T. hyodysenteriae broth culture. During the in vivo test, rectal swabs were taken for T. hyodysenteriae isolation, body weights of all pigs and the feed consumption was determined. All pigs were euthanized and necropsied at study end; the large intestine was cultured for T. hyodysenteriae and gross intestinal lesions were noted. T. hyodysenteriae-caused swine dysentery was successfully controlled by feeding hygromycin A at 5 g/ton. Hygromycin A medicated pigs performed as well as or better than carbadox-medicated pigs.
Kitasato Institute, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
A
A
Nakagawa
T
T
Fujimoto
S
S
Omura
J C
JC
Walsh
R L
RL
Stotish
B
B
George
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D002218:Carbadox / Q000627:therapeutic use; D002934:Cinnamates; D004353:Drug Evaluation, Preclinical; D004403:Dysentery / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D006921:Hygromycin B / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy*; D014211:Treponemal Infections / Q000188:drug therapy / Q000662:veterinary*
D000900:Anti-Bacterial Agents; D002934:Cinnamates; D006921:Hygromycin B; C026273:hygromycin A; D002218:Carbadox