[Effect of immobilization stress on the course of experimental influenza infection and the process of interferon formation].
The experimental data on the peculiar features of interferon production in C57BL/6 mice, infected with the lethal dose of influenza virus and simultaneously subjected to the action of a stress factor, are presented. Immobilization stress was found to exert pronounced influence on the interferon-producing system of the body, which was manifested by the appearance of alpha interferon in a titer of up to 1:80 in the blood of intact animals. 6-hour immobilization preceding infection did not accelerate the development of the lethal from of influenza infection, but sharply suppressed the viral induction of the synthesis of interferon.
B A
BA
Frolov
L K
LK
Chetverikova
T A
TA
Kramskaia
R Ia
RIa
Poliak
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D009980:Influenza A virus / Q000276:immunology / Q000302:isolation & purification; D007370:Interferon Type I / Q000096:biosynthesis* / Q000097:blood; D008168:Lung / Q000382:microbiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000276:immunology*; D013997:Time Factors
D000914:Antibodies, Viral; D007370:Interferon Type I
Vliianie immobilizatsionnogo stressa na techenie éksperimental'noĭ grippoznoĭ infektsii i protsess interferonoobrazovaniia.