Tubular antigen-associated renal disease in New Zealand white rabbits.
Rabbits immunized with autologous renal tubular antigen (Fx1A) developed tubulointerstitial nephritis whereas sheep anti-Fx1A antibody administered i.v. produced glomerulonephritis (GN). This lesion showed heavy granular glomerular deposition of immunoglobulin and subepithelial electron dense deposits, early proteinuria, leucocyte independence and a temporal pattern of quantitated glomerular antibody binding distinct from that reported to occur in passive Heymann's nephritis in rats. Isoelectric focusing followed by immunoblotting of deoxycholate-soluble Fx1A antigens with the heterologous and autologous antibodies, indicated species differences in epitope recognition which could account for dissociation between the two models.
Nicol
M J
MJ
Miller
J H
JH
Neale
T J
TJ
D000818:Animals; D000941:Antigens / Q000276:immunology*; D004195:Disease Models, Animal; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology; D007678:Kidney Glomerulus / Q000648:ultrastructure; D007684:Kidney Tubules / Q000648:ultrastructure; D008854:Microscopy, Electron; D009395:Nephritis, Interstitial / Q000276:immunology* / Q000473:pathology; D011817:Rabbits; D012756:Sheep; D013045:Species Specificity
D000941:Antigens; C035812:renal tubular antigen