Effect of fusarochromanone and T-2 toxin on articular chondrocytes in monolayer culture.
The effect of fusarochromanone and T-2 toxin on DNA synthesis and radio-sulfate incorporation by rabbit articular chondrocytes was studied in monolayer culture. T-2 toxin reduced DNA more than 50% at 5 x 10(-9) M; fusarochromanone caused small but progressive decrements over a range of 5 x 10(-8) to 10(-6) M. These actions are not specific for chondrocytes. The findings lend no support to the hypothesis that fusarochromanone, at least in unmodified form, is the etiologic agent in Kashin-Beck disease.
Department of Pathology, State University of New York, Stony Brook 11794.
G C
GC
Wright
W F
WF
Marasas
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L
Sokoloff
D000596:Amino Acids / Q000633:toxicity*; D000818:Animals; D002358:Cartilage, Articular / Q000166:cytology / Q000187:drug effects*; D002478:Cells, Cultured; D002867:Chromones / Q000633:toxicity*; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D006801:Humans; D009183:Mycotoxins / Q000633:toxicity*; D011509:Proteoglycans / Q000378:metabolism; D011817:Rabbits; D012717:Sesquiterpenes / Q000633:toxicity*; D013605:T-2 Toxin / Q000633:toxicity*
D000596:Amino Acids; D002867:Chromones; D009183:Mycotoxins; D011509:Proteoglycans; D012717:Sesquiterpenes; D004247:DNA; C054523:fusarochromanone; D013605:T-2 Toxin