[Relation between the cytogenetic effect and the dose of radiation and chemical mutagenic exposure of somatic cells in vivo: effect of the duration of exposure and cell selection].
Dose-response relationships obtained in vivo in mammalian cells or in vitro when studying structural chromosome aberrations in somatic cells may be used for monitoring human populations exposed to mutagenic agents. While the method appears of interest for biological dosimetry on people exposed to relatively high doses of ionizing radiation, its value for persons professionally exposed to chemicals is, however, limited.
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Leonard
D000818:Animals; D002066:Busulfan / Q000633:toxicity; D002869:Chromosome Aberrations / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D009152:Mutagenicity Tests; D009153:Mutagens; D011836:Radiation Tolerance; D013045:Species Specificity; D013997:Time Factors
D009153:Mutagens; D002066:Busulfan
Zavisimost' tsitogeneticheskogo éffekta ot dozy radiatsionnogo i khimicheskogo mutagennogo vozdeĭstviia na somaticheskie kletki in vivo: vliianie dlitel'nosti ékspozitsii i kletochnoĭ selektsii.