[Changes in carbohydrate metabolism during experimental alcoholic liver disease].
Decrease in activities of alcohol dehydrogenase and catalase, inhibition of mitochondrial glycerophosphate-, lactate-, malate-, succinate dehydrogenases as well as a decrease in the pool of oxidized nicotinamide coenzymes were observed in liver tissue of rabbits after per oral administration of 30% ethanol within two months. Ratios of substrates of tricarboxylic acid cycle were altered: concentrations of malate and oxaloacetate were decreased and content of alpha-ketoglutarate exceeded distinctly the normal level. Content of glucose, pyruvic and lactic acids were also decreased in liver tissue.
F N
FN
Gil'miiarova
I V
IV
Sidorenkov
V M
VM
Radomskaia
L N
LN
Vinogradova
N N
NN
Mikhaĭlova
D000435:Alcoholic Intoxication / Q000201:enzymology / Q000378:metabolism*; D000818:Animals; D050260:Carbohydrate Metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008108:Liver Diseases, Alcoholic / Q000201:enzymology / Q000378:metabolism*; D009249:NADP; D010084:Oxidation-Reduction; D011817:Rabbits
D009249:NADP
Narusheniia metabolizma uglevodov pri alkogol'nom porazhenii pecheni v éksperimente.