Muscarinic cholinergic receptors and the canine model of narcolepsy.
The role of the muscarinic cholinergic receptor in narcolepsy was examined using radioligand binding to various brain regions of normal and genetically narcoleptic Doberman pinschers. In this multi-litter study, a previous report of a proliferation of muscarinic cholinergic receptors in the brainstem was confirmed, and the concentration of the M2 receptor subtype, in particular, was elevated. This up-regulation of brainstem cholinergic receptors suggests a problem with release of acetylcholine, which, together with previous reports of an impairment of dopamine release, may be indicative of a fundamental membrane problem in narcolepsy.
Kilduff
T S
TS
Bowersox
S S
SS
Kaitin
K I
KI
Baker
T L
TL
Ciaranello
R D
RD
Dement
W C
WC
D000679:Amygdala / Q000032:analysis; D000818:Animals; D001923:Brain Chemistry; D002421:Caudate Nucleus / Q000032:analysis; D005260:Female; D008032:Limbic System / Q000032:analysis; D008297:Male; D009290:Narcolepsy / Q000378:metabolism*; D009833:Olfactory Pathways / Q000032:analysis; D011149:Pons / Q000032:analysis; D011869:Radioligand Assay; D011976:Receptors, Muscarinic / Q000032:analysis*; D012154:Reticular Formation / Q000032:analysis
D011976:Receptors, Muscarinic