Evoked potentials during isoflurane anaesthesia.
Somatosensory, visual and brainstem auditory evoked potentials were recorded in 10 unpremedicated patients anaesthetized with isoflurane in oxygen. Recordings were made at 0.5%, 1.1% and 1.65% (six patients) end-tidal isoflurane concentration. There were statistically significant increases in the latencies of the somatosensory (N20), visual and brainstem auditory potentials (waves III and V) with increasing concentrations of isoflurane. The central conduction time was prolonged. Amplitudes of the somatosensory and visual potentials were reduced with increasing concentrations of isoflurane. The effects of isoflurane on evoked potentials are similar to those of halothane and enflurane. It is possible that changes in evoked potential measurements may be useful as a neurophysiological indicator of anaesthetic depth.
P S
PS
Sebel
D A
DA
Ingram
P J
PJ
Flynn
C F
CF
Rutherfoord
H
H
Rogers
D000769:Anesthesia, Inhalation; D001933:Brain Stem / Q000502:physiology; D005071:Evoked Potentials / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D005074:Evoked Potentials, Visual / Q000187:drug effects; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D008875:Middle Aged; D009609:Nitrous Oxide / Q000494:pharmacology; D013997:Time Factors
D008738:Methyl Ethers; D007530:Isoflurane; D009609:Nitrous Oxide