Inhibitory effect of dietary selenium on carcinogenesis in rat glandular stomach induced by N-methyl-N'-nitro-N-nitrosoguanidine.
The influence of dietary selenium on the incidence of stomach carcinoma induced by N-methyl-N'-nitro-N-nitrosoguanidine was studied in 108 rats that survived for over 10 wk. The incidence of glandular stomach cancer in the high-selenium (4.0 ppm) diet group (20 carcinomas in 54 rats) was lower than in the low-selenium (0.1 ppm) diet group (33 carcinomas in 54 rats). The selenium level and glutathione peroxidase activity in the blood, liver, and stomach mucosa were significantly higher in the high-selenium diet group than in the low-selenium diet group. Glutathione peroxidase activity as well as the concentration of selenium in the glandular stomach was increased significantly in the high-selenium diet group.
Kobayashi
M
M
Kogata
M
M
Yamamura
M
M
Takada
H
H
Hioki
K
K
Yamamoto
M
M
D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002277:Carcinoma / Q000139:chemically induced; D004032:Diet; D005753:Gastric Mucosa / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008769:Methylnitronitrosoguanidine / Q000037:antagonists & inhibitors*; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced; D012643:Selenium / Q000378:metabolism / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000175:diagnosis*
D008769:Methylnitronitrosoguanidine; D005979:Glutathione Peroxidase; D012643:Selenium