A glyoxalase-1 variant associated with the t-complex in house mice.
A quantitative variant of glyoxalase-1 associated with the t-complex in house mice is described. GLO-1C in red cell lysates from mice heterozygous for complementing t-haplotypes and from mice homozygous for the tw8-haplotype had less than one-third the GLO-1 activity of NZB/BlNJ, the inbred strain with the lowest activity previously reported. GLO-1C appeared to be determined by the structural locus Glo-1 and, together with two partial t6-haplotypes, was used to map Glo-1 to the telomeric portion of the t6-haplotype. Glo-1c was associated with all t-haplotypes tested and has not been found in mice that lack a t-complex. Thus, this variant of Glo-1c provides both a further example of gametic disequilibrium between the t-complex and linked loci and a readily identifiable marker for the t-complex.
J H
JH
Nadeau
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D004588:Electrophoresis, Cellulose Acetate; D004912:Erythrocytes / Q000201:enzymology; D008040:Genetic Linkage; D014644:Genetic Variation; D006579:Heterozygote; D006720:Homozygote; D007791:Lactoylglutathione Lyase / Q000097:blood / Q000235:genetics*; D008190:Lyases / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity
D008190:Lyases; D007791:Lactoylglutathione Lyase