Cysteine sulfinate modulated calcium permeability in synaptosomes from rat brain.
Cysteine sulfinate (CSA) was shown to increase 45Ca2+ permeability of plasma membrane of synaptosomes isolated from rat brain. The 45Ca2+ enter through a system which has properties different from those of voltage dependent Ca2+ channels or Na+/Ca2+ exchange. The effect of CSA appeared to be mediated by highly specific receptors saturable by ligand. The high concentrations of CSA required (mM) suggest this amino acid is not the physiological agonist for the receptors.
Department of Biochemistry and Biophysics, Medical School, University of Pennsylvania, Philadelphia 19104-6059.
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Pastuszko
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Wilson
D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000493:pharmacokinetics*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D018377:Neurotransmitter Agents; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D000596:Amino Acids; D002121:Calcium Channel Blockers; D018377:Neurotransmitter Agents; D003545:Cysteine; D002118:Calcium; C013461:cysteine sulfinic acid