The protective effect of Thiola against the genotoxic action of benzo(a)pyrene.
The protective effect of Thiola against the genotoxicity, induced by benzo(a)pyrene, in vitro and in vivo, was investigated. By association of Thiola to benzo(a)pyrene a significant decrease of the numerical and structural chromosome aberrations and a reduction of the incidence of c-mitoses has been obtained in human diploid cells, i.e. human embryonic lung fibroblasts of the cell-line ICP-23, and C56B1/6 mouse bone marrow cells.
Galdean
D
D
Petrasincu
D
D
Alangiu
P
P
Ibric
S
S
Voiculetz
N
N
D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors*; D001853:Bone Marrow / Q000648:ultrastructure; D002460:Cell Line; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D005347:Fibroblasts / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008938:Mitosis / Q000187:drug effects; D008625:Tiopronin / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D001564:Benzo(a)pyrene; D008625:Tiopronin