Bile acid metabolism in the pig.
To study bile acid metabolism in the pig, indwelling catheters were surgically placed in the hepatic portal vein and the anterior vena cava of 12-17 kg crossbred pigs. The pigs were fed ad libitum for one hr at 0800 and 1600 hrs daily. Two weeks after the surgery, 50 microCi of 24[14C] chenodeoxycholic acid were infused into the hepatic portal vein. The radioactivity in plasma from the two veins was monitored hourly for six hrs following each of six consecutive meals over a 3-day period. Fecal and urine radioactivity were determined for 14 days. It was found that the peak levels of radioactivity in the plasma of both veins were reached within two hrs post-feeding. The biological half-life of chenodeoxycholic acid was determined to be 6.4 days.
Tracy
J D
JD
Jensen
A H
AH
Allhands
R V
RV
D000818:Animals; D002635:Chenodeoxycholic Acid / Q000097:blood / Q000378:metabolism*; D004435:Eating; D005243:Feces / Q000032:analysis; D006207:Half-Life; D008297:Male; D011169:Portal Vein; D013552:Swine / Q000378:metabolism*; D013997:Time Factors; D014684:Venae Cavae
D002635:Chenodeoxycholic Acid