[Comparative evaluation of the action of oxythiamine and its derivatives on animals with Erhlich's ascitic cancer].
It is found that hydroxythiamine ester with sebacic acid surpassed hydroxythiamine in its antitumour effect on Ehrlich ascites tumour in albino mice. A linear correlation is observed between the values of activity coefficients of hydroxythiamine and its esters with dicarboxylic acids and some morphometric data.
Zimatkina
T I
TI
Zimatkin
S M
SM
Oparin
D A
DA
Velichko
M G
MG
Ostrovskiĭ
Iu M
IuM
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D003652:Decanoic Acids / Q000627:therapeutic use*; D003998:Dicarboxylic Acids / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004952:Esters; D005260:Female; D005977:Glutarates / Q000627:therapeutic use; D006651:Histocytochemistry; D008099:Liver / Q000378:metabolism; D051379:Mice; D009368:Neoplasm Transplantation; D010119:Oxythiamine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D013835:Thiamine Pyrophosphate / Q000378:metabolism; D013844:Thiazoles / Q000627:therapeutic use*; D013997:Time Factors; D014174:Transketolase / Q000378:metabolism
D000970:Antineoplastic Agents; D003652:Decanoic Acids; D003998:Dicarboxylic Acids; D004952:Esters; D005977:Glutarates; D013844:Thiazoles; D010119:Oxythiamine; C011107:sebacic acid; D014174:Transketolase; D013835:Thiamine Pyrophosphate
Sravnitel'naia otsenka deĭstviia oksitiamina i nekotorykh ego proizvodnykh na zhivotnykh s astsitnym rakom Erlikha.