[Decontamination effectiveness of Ca-, Zn- and MnDTPA chelates in internal contamination with Cs-137, Ce-144, J-131, Sr-90 radioisotopes].
The studies were carried out on 240 rabbits divided into 4 groups, in which, after contamination with i.v. radioisotopes 137Cs (A), 144Ce (B), 131J (C), 90Sr (D), Ca-, Zn-, MnDTPA chelates were used in 12.5% water solutions in doses of 0.4 g/kg of body weight. The evaluation of the decontaminating effectiveness of the above DTPA compounds, taking into account veterinary-clinical and veterinary-sanitary aspects, was made with to the individual radioisotopes on the basis of radiometric studies. These studies carried out after 1,2,4,6,15 days from the contamination, by using a measurement system, concerned the following organs and tissues: blood, brain, heart, muscles of the thigh and arm, lungs, kidneys, liver, stomach, colon, bone, thyroid gland. The results expressing the per cent values of radioactivity of the organs in relation to the dose of the radioisotopes introduced into the organism and to the value of radioactivity of the particular organs in Bq/100 mg of ash, including discussion and conclusions, are presented in individual groups. From these data it can be assumed for practical veterinary purpose that Ca-, Zn-, MnDTPA chelates show an effective action with respect to the veterinary-clinical aspect in contamination with radiocerium, and with respect to the veterinary-sanitary aspect in contamination with radiocerium and radioiiodine; less effective action with respect to the veterinary-sanitary aspect, and ineffective with respect to the veterinary-clinical aspect in contamination with radiocesium; negative one with respect to both aspects in contamination with radiostrontium. As regards the individual chelating compounds, the most effective can be recognized sodium zinc salt of DTPA.
Ośrodek Naukowo-Badawczy Słuzby Weterynaryjnej w Puławach.
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Kossakowski
D000818:Animals; D002565:Cerium Radioisotopes / Q000633:toxicity; D002588:Cesium Radioisotopes / Q000633:toxicity; D002614:Chelating Agents / Q000494:pharmacology*; D003666:Decontamination; D007457:Iodine Radioisotopes / Q000633:toxicity; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011851:Radioactivity; D013326:Strontium Radioisotopes / Q000633:toxicity
D002565:Cerium Radioisotopes; D002588:Cesium Radioisotopes; D002614:Chelating Agents; D007457:Iodine Radioisotopes; D013326:Strontium Radioisotopes
Skuteczność dekontaminacyjna chelatów Ca-, Zn-, MnDTPA przy skazeniach wewnetrznych radioizotopami 137Cs, 144Ce, 131J, 90Sr.