Effects of diazepam, pentobarbital, phenytoin and pentylenetetrazol on hippocampal paired-pulse inhibition in vivo.
The effects of diazepam, pentobarbital, phenytoin and pentylenetetrazol on paired-pulse inhibition were assessed in the intact rat hippocampus. Diazepam (4 mg/kg i.p.) and pentobarbital (15 mg/kg i.p.) increased inhibition over control levels, while phenytoin (15 mg/kg i.p.) and pentylenetetrazol (20 mg/kg i.p.) decreased inhibition from control levels. The present results with diazepam, pentobarbital and pentylenetetrazol confirm previous reports. However, the present results indicate that augmentation of GABA-ergic inhibition is not involved in the anticonvulsant action of phenytoin.
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D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology*; D004597:Electroshock; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007274:Injections, Intraperitoneal; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D005680:gamma-Aminobutyric Acid; D010672:Phenytoin; D010424:Pentobarbital; D003975:Diazepam; D010433:Pentylenetetrazole