Effect of GABAergic drugs in the behavioral 'despair' test in rats.
Aminooxyacetic acid (AOAA, 25 mg/kg i.p.), muscimol (2 mg/kg i.p.) and 4,5,6,7-tetrahydroisooxazol-[4,5-c]-pyridin-3-ol (THIP, 5 and 10 mg/kg s.c.), but not baclofen (10 mg/kg i.p.) administered three times (24, 5 and 1 h before the test) decreased the immobility time of rats in the behavioral 'despair' test. At these doses, AOAA, muscimol and THIP reduced motor activity. Muscimol (2 mg/kg) and THIP (5 and 10 mg/kg) exerted the antiimmobility effect even after single dosing 1 h before the test. Picrotoxin (1 and 2 mg/kg i.p.), but not bicuculline (2 mg/kg i.p.), prevented the effect of both muscimol and THIP in the behavioral 'despair' test.
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Borsini
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Evangelista
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Meli
D000085:Acetates / Q000494:pharmacology*; D000625:Aminooxyacetic Acid / Q000494:pharmacology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001640:Bicuculline / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007555:Isoxazoles / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009118:Muscimol / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000085:Acetates; D000625:Aminooxyacetic Acid; D001418:Baclofen; D001640:Bicuculline; D007555:Isoxazoles; D009118:Muscimol; D010080:Oxazoles; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid; C026804:4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridin-3-ol