Calcemic responses to photic and pharmacologic manipulation of serum melatonin.
Phototherapy of newborn rats (NBR) resulted in a decrease in serum calcium and melatonin levels. Transcranial light penetrance in NBR increased with wavelength. Below 640 nm (penetrance = 6.9%), no hypocalcemic effect could be demonstrated. Shielding the occiput of NBR prevented a decrease in serum calcium during phototherapy and substantially reduced the decrease in melatonin found in unshielded NBR. Intraperitoneal injection of propranolol, an inhibitor of melatonin synthesis, caused a decrease in serum calcium in shaded NBR. In contrast, when melatonin was injected with propranolol a decrease in serum calcium did not occur. Additionally, intraperitoneal isoproterenol before phototherapy protected against a decrease in serum calcium. These data are consistent with an hypothesis that a decrease in serum calcium during phototherapy results from transcranial photic inhibition of melatonin synthesis.
Hakanson
D O
DO
Department of Pediatrics, SUNY Health Science Center, Syracuse 13210.
Penny
R
R
Bergstrom
W H
WH
D000818:Animals; D002118:Calcium / Q000097:blood*; D004388:Dura Mater; D008550:Melatonin / Q000097:blood*; D010775:Photic Stimulation; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D012886:Skull
D011433:Propranolol; D008550:Melatonin; D002118:Calcium