Cortical atrophy in young adults with a history of hyperactivity in childhood.
A computed tomographic (CT) brain scan study was conducted in 24 young males treated and followed up for hyperactivity since childhood. Compared to 27 matched controls, adults with a history of hyperactivity had a significantly greater frequency of cerebral atrophy. No differences in cerebellar atrophy frequency or in lateral cerebral ventricle-to-brain ratio (VBR) were found. The possible associations of hyperactivity or perhaps stimulant drug treatment to atrophic brain changes are discussed.
H A
HA
Nasrallah
J
J
Loney
S C
SC
Olson
M
M
McCalley-Whitters
J
J
Kramer
C G
CG
Jacoby
D000328:Adult; D001284:Atrophy; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000209:etiology; D002540:Cerebral Cortex / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000009:adverse effects; D014057:Tomography, X-Ray Computed
D008774:Methylphenidate