The application of 15N-NMR spectroscopy in the problems of nucleoside and nucleotide chemistry.
15N-NMR spectroscopy has been shown to be useful to understand the chemical nature of nitrogen in a biomolecule. We herein report the use of 15N-NMR as a tool for the study of exact location of a substitution on the guanine or uracil moieties in a nucleoside, to understand the implication of a protecting group on the reactivity and the basicity of nitrogen atoms in pyrimidines or in purines and to assign the structure of isomeric N7 and N9 substituted purines.
Department of Bio-organic Chemistry, University of Uppsala, Sweden.
G
G
Remaud
X X
XX
Zhou
C J
CJ
Welch
J
J
Chattopadhyaya
D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009705:Nucleosides; D009711:Nucleotides; D013329:Structure-Activity Relationship
D009705:Nucleosides; D009711:Nucleotides