New peptide antibiotics LI-F03, F04, F05, F07, and F08, produced by Bacillus polymyxa. I. Isolation and characterization.
A strain of Bacillus polymyxa produced a new peptide antibiotic complex, named LI-F, composed of more than ten components. The components, antibiotics LI-F03, F04, F05, F07, and F08 were isolated from the complex by reversed phase HPLC. They are active against fungi, yeasts, and Gram-positive bacteria. The fast atom bombardment mass spectra revealed that the individual isolated antibiotics are still mixture of two homologous components, being very difficult to separate from each other.
Kurusu
K
K
Biological Science Laboratories, Lion Corporation, Kanagawa, Japan.
Ohba
K
K
Arai
T
T
Fukushima
K
K
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000633:toxicity; D002851:Chromatography, High Pressure Liquid; D007274:Injections, Intraperitoneal; D051379:Mice; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000302:isolation & purification* / Q000633:toxicity
D000900:Anti-Bacterial Agents; D010455:Peptides