[Nature of the immunotropic activity of calcium antagonists].
It was shown in experiments on CBA mice that four-fold administration of calcium antagonists (verapamil, nifedipine) in doses of 5-10 mg/kg was accompanied by the development of the immunosuppressive effect. Reactions of hypersensitivity of delayed type were inhibited to the greatest degree. To a lesser degree calcium antagonists suppressed the humoral immune responses to the thymus-dependent antigen without exerting any action on the formation of antibodies to the thymus-independent antigen.
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Iampol'skiĭ
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Ratnikov
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects*; D007114:Immunization; D007166:Immunosuppressive Agents; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009543:Nifedipine / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D007166:Immunosuppressive Agents; D014700:Verapamil; D009543:Nifedipine
Izuchenie kharaktera immunotropnoĭ aktivnosti nekotorykh antagonistov kal'tsiia.