Chromogranin C: a third component of the acidic proteins in chromaffin granules.
We characterized a group of acidic proteins of bovine chromaffin granules with an antiserum raised against a protein described by Rosa and Zanini [Eur. J. Cell Biol. 31, 94-98 (1983)] in pituitary gland. In adrenal medulla the proteins reacting with this antiserum are confined to chromaffin granules. Their largest component has a Mr of 86,000 and a pI of 5.0. In addition six proteins of lower molecular weight are recognized by this antiserum. In a cell-free system only one protein is synthesized that can be precipitated with this antiserum. The properties of these proteins are very similar to those of the previously described chromogranins A and B; however, there is no immunological cross-reaction between these protein groups. We suggest this third group of acidic proteins of chromaffin granules be named chromogranins C.
Fischer-Colbrie
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R
Hagn
C
C
Kilpatrick
L
L
Winkler
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H
D000818:Animals; D002417:Cattle; D002499:Centrifugation, Density Gradient; D055598:Chemical Phenomena; D002621:Chemistry; D002837:Chromaffin Granules / Q000378:metabolism*; D002838:Chromaffin System / Q000378:metabolism*; D002864:Chromogranins / Q000378:metabolism*; D007106:Immune Sera / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011506:Proteins; D013347:Subcellular Fractions / Q000378:metabolism; D014018:Tissue Distribution
D002864:Chromogranins; D007106:Immune Sera; D009419:Nerve Tissue Proteins; D011506:Proteins