[Prevention of heart damage by extreme physical stress and increasing its resistance to acute overstrain with the antioxidant ionol].
A study of the effect of extreme physical stress on the contractility of an isolated heart, its CPK loss associated with anoxia and reoxygenation, and myocardial adenyl components and lactate levels under acute overstrain of the heart achieved through a complete obstruction of the aorta, showed the animals doing exercise to have reduced cardiac contractility, increased perfusate CPK waste, and sharply decreased myocardial macroergic phosphate levels under acute overstrain by pressure. Pretreatment with ionol largely prevented these changes.
Meerson
F Z
FZ
Krasikov
S I
SI
Ustinova
E E
EE
Golubeva
L Iu
LIu
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage*; D003402:Creatine Kinase / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000517:prevention & control*
D000227:Adenine Nucleotides; D007773:Lactates; D010710:Phosphates; D002084:Butylated Hydroxytoluene; D019344:Lactic Acid; D003402:Creatine Kinase
Preduprezhdenie povrezhdeniia serdtsa pri predel'noĭ fizicheskoĭ rabote i povyshenie ego rezistentnosti k ostroĭ peregruzke s pomoshch'iu antioksidanta ionola.