The stabilizing effect of synovectomy on the synovial membrane in arthritic rabbit knees.
An inflammatory arthritis was induced in rabbit knees by intra-articular injection of human IgG complex in immunized animals. A increased invasion of large plasma proteins into the arthritic knee could be measured by electrophoretic separation of synovial extract and autoradiographic detection of 125I-labeled proteins. Synovectomy resulted in a reduced invasion of plasma proteins compared with the preoperatively arthritic knees. This protective effect was lost, however, following repeated intra-articular IgG injections. Fibrosis and decreased vascularization of the synovectomized knee, the excision of inflammatory cells, and mediators of inflammation are discussed as possible explanations.
W
W
Reichel
K J
KJ
Weber
D000818:Animals; D001168:Arthritis / Q000473:pathology / Q000601:surgery*; D001169:Arthritis, Experimental / Q000209:etiology / Q000473:pathology / Q000601:surgery; D001345:Autoradiography; D001798:Blood Proteins / Q000032:analysis / Q000378:metabolism; D004586:Electrophoresis; D007074:Immunoglobulin G / Q000008:administration & dosage; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications; D011817:Rabbits; D000074402:Synovectomy; D013583:Synovial Membrane / Q000378:metabolism / Q000473:pathology; D013585:Synovitis / Q000209:etiology
D001798:Blood Proteins; D007074:Immunoglobulin G