High yield of micronuclei and micronuclei premature chromosome condensation in a mouse tumor cell line cultured in vivo with prearrested mitotic metaphases.
It is generally argued that micronuclei and micronuclei premature chromosome condensation (MN PCC) in stable cell lines occur only after treatment with potent clastogens, mutagens or carcinogens. In the present paper we report on the occurrence of micronuclei and MN PCC (predominantly of S type) at a high frequency in a mixed in vivo culture of prearrested mitotic metaphases with an asynchronous population of mouse ascites tumor cells (S180) without the aid of any clastogen, mutagen or carcinogen.
Department of Zoology, Burdwan University, India.
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Chakrabarti
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Chakrabarti
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D002467:Cell Nucleus / Q000187:drug effects / Q000473:pathology*; D002843:Chromatin / Q000187:drug effects; D002875:Chromosomes / Q000473:pathology*; D003078:Colchicine / Q000494:pharmacology; D008677:Metaphase / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D011003:Ploidies / Q000187:drug effects; D013997:Time Factors; D014407:Tumor Cells, Cultured
D002843:Chromatin; D003078:Colchicine