The protection of infant mice from colonization with Campylobacter jejuni by vaccination of the dams.
Intraperitoneal vaccination of female mice, before mating, with a whole cell, heat-killed (62 degrees C) vaccine of Campylobacter jejuni allowed the mother to confer immunity to her young, challenged orally 4-6 days after birth with the homologous strain. There was no protection against a strain of another serotype. Heating the vaccine to 100 degrees C destroyed its protective properties. A vaccine prepared from an aflagellate variant of the original strain was as protective as the original vaccine against challenge with the flagellated strain. Anti-flagellar serum antibody titres of the dams did not correlate with protection of their young.
Dolby
J M
JM
Newell
D G
DG
D000818:Animals; D000831:Animals, Newborn / Q000382:microbiology*; D002169:Campylobacter Infections / Q000517:prevention & control*; D002168:Campylobacter fetus / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005407:Flagella / Q000276:immunology; D007112:Immunity, Maternally-Acquired; D008565:Membrane Proteins / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D013045:Species Specificity; D014611:Vaccination
D008565:Membrane Proteins