Increase of plasma and red cell cholesterol sulfate levels in induced hypothyroidism in man.
Plasma and erythrocyte cholesterol sulfate-, erythrocyte cholesterol-, and serum unesterified- and total cholesterol levels of ten athyreotic thyroid cancer patients were measured during triiodothyronine supplementation, and subsequently at the end of a two weeks withdrawal of this medication. The results showed that in the hypothyroid state all above mentioned parameters increased except for the erythrocyte cholesterol level, which remained unchanged. The interrelationships between these parameters, and the exchange mechanism of cholesterol sulfate between plasma and erythrocytes are discussed.
van Doormaal
J J
JJ
Muskiet
F A
FA
Jansen
G
G
Wolthers
B G
BG
Sluiter
W J
WJ
Doorenbos
H
H
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D002788:Cholesterol Esters / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000378:metabolism; D014284:Triiodothyronine / Q000627:therapeutic use
D002788:Cholesterol Esters; D014284:Triiodothyronine; D002784:Cholesterol; C007045:cholesteryl sulfate