The 5q-- deletion: correlation of breakpoints with the immunophenotype of leukemic blast cells.
Cytogenetic and immunologic features of 13 patients with the 5q- deletion with the diagnosis of acute leukemia, either as the blastic transformation of a typical 5q- syndrome or myeloproliferative disorder or as a de novo presentation, were studied. Variable 5q- breakpoints were identified: The common interstitial deletion at q13q33 was found in nine cases, and a terminal deletion at q13, q22, q22, q31, respectively, was found in four cases, two of which had unbalanced translocations. A comparison of 5q- breakpoints with the blast cell immunophenotype indicated an association of myeloid and TdT+/myeloid leukemias with interstitial deletions and of monoblastic phenotypes with terminal deletions.
Paietta
E
E
Department of Oncology, Montefiore Medical Center, Bronx, New York 10467.
Papenhausen
P
P
Gucalp
R
R
Reed
J
J
Wiernik
P H
PH
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000954:Antigens, Surface / Q000032:analysis; D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure*; D004253:DNA Nucleotidylexotransferase / Q000032:analysis; D006801:Humans; D007938:Leukemia / Q000145:classification / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D014411:Neoplastic Stem Cells / Q000032:analysis / Q000276:immunology / Q000648:ultrastructure*; D010641:Phenotype
D000954:Antigens, Surface; D009363:Neoplasm Proteins; D004253:DNA Nucleotidylexotransferase