The effect of apomorphine and pergolide on the potassium-evoked overflow of GABA in rat striatum studied by microdialysis.
The extracellular GABA concentration in the rat striatum was measured by the microdialysis technique. Addition of pergolide (10(-4) M) to the perfusion medium decreased the GABA overflow induced by high K+ but apomorphine (10(-4) M) had no effect on the GABA overflow. When sulpiride (10(-4) M) was added to the perfusion medium, the pergolide effect on stimulated GABA overflow was abolished. The results indicate that D2-receptors are able to modulate GABA overflow in the striatum.
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Tossman
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Ungerstedt
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D003956:Dialysis; D004873:Ergolines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010477:Perfusion; D010479:Pergolide; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D004873:Ergolines; D011954:Receptors, Dopamine; D010479:Pergolide; D005680:gamma-Aminobutyric Acid; D001058:Apomorphine; D011188:Potassium