2'-fluorinated pyrimidine isonucleosides. Novel nucleoside analogs demonstrate therapeutic activity in mice with tumors.
Grace Cancer Drug Center, Department of Experimental Therapeutics, Roswell Park Memorial Institute, Buffalo NY 14263.
M
M
Bobek
S H
SH
An
D
D
Skrincosky
E
E
De Clerq
R J
RJ
Bernacki
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D005461:Fluorine; D007202:Indicators and Reagents; D007939:Leukemia L1210 / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D051379:Mice; D008811:Mice, Inbred DBA; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000627:therapeutic use; D012513:Sarcoma, Experimental / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D011684:Purine Nucleosides; D005461:Fluorine