[Effect of ascorbic acid on the development of a spontaneous lymphoproliferative process in SJL/J-strain mice].
Ascorbic acid (AA) effects on the development of lymphoproliferative process according to the type of a reticular variant of Hodgkin's disease have been investigated in SJL/J mice. An oral AA injection in a 0.05% aqueous solution for 6-8 months (0.625 mg/kg) with a total dose of 0.5 per mouse has not produced any side effects, has reduced both the rate of tumour process development (from 80.5% in control to 68.0% in experiment) and the degree of its extension, and also has led to a statistically significant decrease in the frequency of development of general amyloidosis.
L I
LI
Korytova
A V
AV
Gubareva
D000375:Aging / Q000187:drug effects; D000686:Amyloidosis / Q000188:drug therapy / Q000209:etiology; D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000209:etiology; D008232:Lymphoproliferative Disorders / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D001205:Ascorbic Acid
Vliianie askorbinovoĭ kisloty na razvitie spontannogo limfoproliferativnogo protsessa u mysheĭ linii SJL/L.