Acyclic model peptides with ionophoretic activity. Pr3+ transport by N-tBoc-Pro-Xxx-Ala-NHCH3.
Two linear synthetic peptides, N-tBoc-Pro-Gly-Ala-NHCH3 and N-tBoc-Pro-D-Ala-Ala-NHCH3, have previously been shown by us to complex with Ca2+ and form 2:1 (peptide:calcium) complexes. Here we report their binding to Pr3+ and demonstrate, by 1H NMR, the peptide-mediated transport of Pr3+ across dimyristoylphosphatidylcholine unilamellar vesicles via a 2:1 ion-sandwich complex.
Shastri
B P
BP
Rehse
P H
PH
Attah-Poku
S K
SK
Ananthanarayanan
V S
VS
D001692:Biological Transport; D002118:Calcium; D002794:Choline; D007476:Ionophores; D007700:Kinetics; D008954:Models, Biological; D009842:Oligopeptides; D011221:Praseodymium; D011487:Protein Conformation; D013329:Structure-Activity Relationship
D007476:Ionophores; D009842:Oligopeptides; C048917:N-tert-butyloxycarbonyl-prolyl-alanyl-alanyl-methylamide; C048916:N-tert-butyloxycarbonyl-prolyl-glycyl-alanyl-methylamide; D002794:Choline; D011221:Praseodymium; D002118:Calcium