A simple procedure for synthesis of diastereoisomers of thymidine cyclic 3',5'-phosphate derivatives.
Diastereoisomeric thymidine cyclic (3',5')-methanephosphonates (3a), cyclic (3',5')-phosphoranilidates (3b) and cyclic (3',5')-phosphoranilidothioates (3c) were prepared by treatment of diastereoisomerically pure thymidine 3'-O-[O-(4-nitrophenyl)methanephosphonates] (2a), 3'-O-[O-(4-nitrophenyl)phosphoranilidates] (2b) or 3'-O-[O-(4-nitrophenyl)phosphoranilidothioates] (2c), respectively, with sodium hydroxide in dioxane-water solution.
Polish Academy of Sciences, Department of Bio-organic Chemistry, Lodz.
Z J
ZJ
Lesnikowski
M
M
Jaworska
W J
WJ
Stec
D007202:Indicators and Reagents; D013237:Stereoisomerism; D013942:Thymine Nucleotides / Q000138:chemical synthesis* / Q000302:isolation & purification
D007202:Indicators and Reagents; D013942:Thymine Nucleotides