Hemostatic parameters in newborn--I. Effect of gestation and rate of intrauterine growth.
The present study comprises of 208 term, 159 preterm and 18 post-term neonates born to mothers with no history of drug intake or any disease likely to effect coagulation of the newborn. PT, TT and KCCT were relatively prolonged and plasma fibrinogen reduced to varying degree in newborns (as compared to adults). There was further prolongation of TT and reduction in plasma fibrinogen levels amongst preterm newborns as compared to term babies; TT was more prolonged amongst post-term babies also. PT was significantly more prolonged till 30 weeks of gestation, after which a near plateau was formed. KCCT showed significant improvement after 33 weeks and a further trend to normalisation after 38 weeks of gestation. Serum FDP values showed too much of variation for any meaningful statistical analysis but generally FDPs were higher in preterm babies. Intrauterine growth rate had no significant effect on these parameters amongst preterms - similar values for SGA (small for gestational age), AGA (appropriate for gestational age) and LGA (large for gestational age). On the other hand, amongst term babies SGA neonates had significantly prolonged PT and low plasma fibrinogen as compared to AGA; LGA babies also showed more prolongation of TT as compared to AGA.
Dube
B
B
Dube
R K
RK
Bhargava
V
V
Kolindewala
J K
JK
Kota
V L
VL
Das
B K
BK
D005314:Embryonic and Fetal Development; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005865:Gestational Age; D006487:Hemostasis; D006801:Humans; D007231:Infant, Newborn; D007233:Infant, Postmature; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D013918:Thrombin Time
D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen