Small bowel ulceration in patients receiving non-steroidal anti-inflammatory drugs for rheumatoid arthritis.
Evidence is presented for a non-specific ulcerative process in the small bowel of patients with rheumatoid arthritis. All three cases presented with lower gastrointestinal bleeding; on withdrawal of non-steroidal anti-inflammatory drugs no further bleeding occurred. Non-steroidal anti-inflammatory drugs may lead to small bowel ulceration in inhibiting mucosal glycoprotein synthesis and increasing intestinal permeability.
Madhok
R
R
MacKenzie
J A
JA
Lee
F D
FD
Bruckner
F E
FE
Terry
T R
TR
Sturrock
R D
RD
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000139:chemically induced* / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014456:Ulcer / Q000139:chemically induced / Q000473:pathology
D000893:Anti-Inflammatory Agents