Hepatic enzyme induction and vitamin K1 elimination in man.
We have studied the effect of hepatic enzyme induction on vitamin K1 elimination in patients on long-term anticonvulsant therapy and in volunteers given rifampicin. Neither the anticonvulsants (phenytoin and phenobarbitone) nor rifampicin had any significant effect on vitamin K1 elimination half-life or AUC. The neonatal haemorrhage which occurs in babies born to mothers on long-term enzyme inducing drugs is unlikely to be related to an increased rate of vitamin K elimination in the mother.
Scott
A K
AK
Department of Medicine and Therapeutics, University of Aberdeen, Scotland.
Haynes
B P
BP
Schinkel
K D
KD
Ohnhaus
E E
EE
Park
B K
BK
D000328:Adult; D000927:Anticonvulsants / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000494:pharmacology; D014812:Vitamin K / Q000097:blood / Q000493:pharmacokinetics*
D000927:Anticonvulsants; D014812:Vitamin K; D012293:Rifampin