Pipecolic acid enhancement of GABA response in single neurons of rat brain.
Using unit recording and microelectrophoresis, influence of pipecolic acid (PA), a major metabolite of lysine in the brain, on GABA and glycine responses was studied in the cerebral cortical and hippocampal pyramidal neurons of rats. With small currents, PA had no effect on the single neuron activities but enhanced GABA response without affecting glycine response. The finding provides a new evidence that PA may have a connection with central GABA system.
K
K
Takahama
T
T
Hashimoto
M W
MW
Wang
N
N
Akaike
T
T
Hitoshi
Y
Y
Okano
Y
Y
Kasé
T
T
Miyata
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D004357:Drug Synergism; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000378:metabolism* / Q000502:physiology; D010875:Pipecolic Acids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D010875:Pipecolic Acids; D005680:gamma-Aminobutyric Acid; C031345:pipecolic acid