[In vitro study of various ionophore antibiotics and some of their derivatives. II. Characterization of the ionophore properties of the compounds in a model system for Na+ and K+ ions].
Transport of Na+ and K+ by different carboxylic polyether antibiotics and some of their derivatives was measured in a triphasic water/chloroform/water model system. Monensin, nigericin, narasin and lasalocid proved to be efficient K+ carriers, while grisorixin, alborixin and X 14547A gave lower ionic fluxes. Furthermore, the structural modifications of nigericin, grisorixin and lasalocid reduced the ionophore properties of the corresponding natural metabolite. Monensin was also characterized as a good Na+ carrier. Cation transport results were in keeping with those of a previous study on the end-products of rumen fermentation. In both cases monensin, nigericin, narasin and lasalocid were the most efficient compounds.
Caffarel-Mendez
S
S
Laboratoire de Chimie Organique Biologique (UA 485 du CNRS), Université de Clermont-Ferrand II, Aubière, France.
Demuynck
C
C
Jeminet
G
G
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001692:Biological Transport; D066298:In Vitro Techniques; D007476:Ionophores / Q000378:metabolism*; D008954:Models, Biological; D011188:Potassium / Q000493:pharmacokinetics*; D012964:Sodium / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D007476:Ionophores; D012964:Sodium; D011188:Potassium
Etude "in vitro" de quelques antibiotiques ionophores et de certains de leurs dérivés. II. Caractérisation des propriétés ionophores des composés dans un système modèle, pour les ions Na+ et K+.