[Effect of glucocorticoid hormones on the antigen-induced response of the cyclase systems of splenic cells in the rat and mouse].
The cyclic nucleotides level in rat and mouse cells increased after immunization with SRBS. These changes were absent in the tolerant mouse spleen. The cyclic nucleotides level in the rat spleen cells increased after injection of 0.5-1.0 mg, but not 5 mg/100 g of body weight of cortisol. Administration of cortisol (1-5 mg/100 g but not 0.5 mg/100 g) 10 min before immunization with SRBS (1 X 10(9) cells) prevents the elevation of cyclic nucleotides level induced by the antigen. Adrenalectomy 2 days before immunization results in the inhibition of cAMP reaction to antigen. The reaction of cyclic nucleotides of the spleen cells to antigen in the whole organism seems to depend on the hormones of the hypothalamus-hypophysis-adrenal-cortex system. It is possible that some optimal level of these hormones is necessary for the normal response of the spleen cells cyclic nucleotides to antigen.
M P
MP
Lesnikova
E K
EK
Shkhinek
D000315:Adrenalectomy; D000818:Animals; D004912:Erythrocytes / Q000276:immunology; D006388:Hemagglutinins / Q000032:analysis*; D006824:Hybridization, Genetic; D006854:Hydrocortisone / Q000494:pharmacology*; D007114:Immunization; D008214:Lymphocytes / Q000032:analysis*; D008297:Male; D009712:Nucleotides, Cyclic / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000032:analysis*
D006388:Hemagglutinins; D009712:Nucleotides, Cyclic; D006854:Hydrocortisone
Vliianie gliukokortikoidnykh gormonov na reaktsii tsiklaznykh sistem kletok selezenki, vyzvannye antigenami, u krys i mysheĭ.