Chronic experimental allergic neuritis. An electrophysiological and histological study in the rabbit.
Ten adult outbred New Zealand white rabbits were inoculated with a single multiportal dose of purified bovine peripheral nerve myelin and Freund's adjuvant containing 500 mg of nerve antigen. Seven animals developed chronic relapsing or progressive disease which was followed by clinical examination for 14 months. Electrophysiological studies showed marked slowing of motor conduction velocity, dispersion of the evoked muscle action potential (MAP) and reduction in amplitude of the MAP derived from distal stimulation. Histological examination of the peripheral nervous system showed at 12 months a marked hypertrophic neuropathy in the nerve roots with well developed onion bulbs, active demyelination and a moderate nerve fibre loss. It is suggested that these animals provide a reliable and predictable model for human chronic inflammatory demyelinating polyneuropathy (CIDP) which should prove valuable for therapeutic trials and studies of pathogenetic mechanisms.
Department of Medicine, University of Sydney, NSW, Australia.
G K
GK
Harvey
J D
JD
Pollard
K
K
Schindhelm
J
J
Antony
D000818:Animals; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D004558:Electric Stimulation; D008854:Microscopy, Electron; D009046:Motor Neurons / Q000503:physiopathology* / Q000648:ultrastructure; D009185:Myelin Proteins; D009431:Neural Conduction; D009444:Neuritis, Autoimmune, Experimental / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D011817:Rabbits; D012584:Sciatic Nerve / Q000503:physiopathology / Q000648:ultrastructure; D013126:Spinal Nerve Roots / Q000503:physiopathology / Q000648:ultrastructure; D013997:Time Factors
D009185:Myelin Proteins