Structures of new antibiotics napyradiomycins.
Structures of novel antibiotics, napyradiomycins A, B1, B2, B3, C1 and C2 were determined. By X-ray crystallography, napyradiomycin B2 was determined to be (3R,10aR)-3-chloro-10a-[[(1R,3S)-3-chloro-2, 2-dimethyl-6-methylenecyclohexyl]methyl]-3,10a-dihydro-6,8-dihydro xy-2, 2-dimethyl-2H-naphtho[2,3-b]pyran-5,10-dione. The structures of other napyradiomycins were elucidated by NMR studies. Napyradiomycins C1 and C2 have unique structures which contain 14-membered ring cyclized by carbon-carbon bond.
Shiomi
K
K
Nakamura
H
H
Iinuma
H
H
Naganawa
H
H
Isshiki
K
K
Takeuchi
T
T
Umezawa
H
H
Iitaka
Y
Y
D000900:Anti-Bacterial Agents; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents