Placental electron microscopy and histochemistry in a case of sialic acid storage disorder.
Morphological alterations in a placenta from a case of infantile sialic acid storage disease are described. Syncytiotrophoblast, villous capillary endothelial cells, amniotic and Hofbaüer cells were filled with membrane-bound inclusions which were either electron-lucent or contained fibrillogranular material. Hydrolysis of slides with neuraminidase demonstrated at six hours Alcian blue material which was not present in normal syncytium. The possibility that a storage disorder such as sialic acid storage disease can be accurately diagnosed by electron microscopy on chorion villous sampling at nine to ten weeks is emphasized.
Department of Obstetrics and Gynaecology, Hôpital Universitaire St Pierre, Free University of Brussels, Belgium.
E
E
Jauniaux
E
E
Vamos
J
J
Libert
N
N
Elkhazen
P
P
Wilkin
J
J
Hustin
D000328:Adult; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008661:Metabolism, Inborn Errors / Q000473:pathology*; D008854:Microscopy, Electron; D019158:N-Acetylneuraminic Acid; D009439:Neuraminidase; D010920:Placenta / Q000473:pathology* / Q000648:ultrastructure; D011247:Pregnancy; D012794:Sialic Acids / Q000378:metabolism*
D012794:Sialic Acids; D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid