DMSO potentiates aminonucleoside of puromycin nephrosis in rats.
Dimethyl sulphoxide (DMSO), 3 g/kg body weight, administered daily by the intraperitoneal route, potentiated the proteinuria and formation of tubular casts in aminonucleoside of puromycin (PA) induced nephrosis in Sprague-Dawley rats. The effect was evident at 4 as well as 8-9 days following PA administration. In the absence of PA, DMSO did not induce proteinuria or cast formation. The mechanism by which DMSO enhanced proteinuria and cast formation is not known.
Department of Pathology, California College of Medicine, University of California at Irvine 92717.
G S
GS
Spear
D
D
Nguyen
S
S
Conklin
J S
JS
Wikle
J
J
Fan
Y H
YH
Lan
J
J
Allen
S
S
Reineck
D000818:Animals; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004357:Drug Synergism; D007668:Kidney / Q000473:pathology; D008297:Male; D009402:Nephrosis, Lipoid / Q000139:chemically induced* / Q000473:pathology; D011507:Proteinuria / Q000139:chemically induced; D011691:Puromycin / Q000031:analogs & derivatives*; D011692:Puromycin Aminonucleoside / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D011691:Puromycin; D011692:Puromycin Aminonucleoside; D004121:Dimethyl Sulfoxide