[Relation between the rate of ubiquinone biosynthesis and the activity of cholesterogenesis in the rat liver and kidney].
Incorporation of I-14C-acetate into ubiquinone and sterols was studied in liver and kidney tissues of rats after intragastric administration of cholesterol as well as in the animals kept within 2 days on a diet containing cholestyramine or after the bile duct ligation. The rate of incorporation of the labelled compounds into liver sterols was distinctly decreased within the night under the influence of cholesterol-containing diet, while the higher rate of incorporation of the labelled compounds was found in liver tissue of rats, treated with cholestyramine or after bile duct ligation as well as in control animals during night. Regression-correlation analysis demonstrated the positive linear correlation between rates of incorporation of the labelled compounds into ubiquinone and sterols in liver tissue of all the rat group studied. The corresponding correlation was less distinct in kidney tissue.
Fedurov
V V
VV
Belomar
L B
LB
D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D007668:Kidney / Q000201:enzymology / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D012044:Regression Analysis; D014451:Ubiquinone / Q000096:biosynthesis*
D014451:Ubiquinone; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases
Zavisimost' skorosti biosinteza ubikhinona ot aktivnosti kholesterinogeneza v pecheni i pochkakh krys.