Stacking and hydrogen bonding interactions between phenylalanine and guanine nucleotide: crystal structure of L-phenylalanine-7-methylguanosine-5'-monophosphate complex.
The crystal structure of title complex has been analyzed by X-ray diffraction method as a model for elucidating the possible interaction between the phenylalanyl residue of proteins and the N7-protonated or methylated guanine base of nucleic acids. The guanine base is associated with the benzene ring of phenylalanine by stacking interaction, and further connected with the carboxyl group by the formation of a pair of hydrogen bonds. These two interaction modes are suggested to be responsible for the specific recognition of base sequence by protein.
T
T
Ishida
K
K
Kamiichi
A
A
Kuwahara
M
M
Doi
M
M
Inoue
D002352:Carrier Proteins / Q000378:metabolism; D003460:Crystallization; D006150:Guanine Nucleotides / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D010649:Phenylalanine / Q000378:metabolism*; D012314:RNA Cap Analogs / Q000494:pharmacology; D039381:RNA Cap-Binding Proteins; D012333:RNA, Messenger / Q000378:metabolism; D014961:X-Ray Diffraction
D002352:Carrier Proteins; D006150:Guanine Nucleotides; D012314:RNA Cap Analogs; D039381:RNA Cap-Binding Proteins; D012333:RNA, Messenger; C011925:7-methylguanosine-5'-monophosphate; D010649:Phenylalanine