Comparison of the toxicity of I-653 and isoflurane in rats: a test of the effect of repeated anesthesia and use of dry soda lime.
The low solubility and high stability of the new volatile anesthetic, I-653, suggest that this agent should have little or no toxic effect. This hypothesis was tested using repeated exposures to I-653, to isoflurane, or to no anesthetic. For 2 consecutive weeks, groups of 16 rats each were subjected to a total of six 2-hr exposures to 100% oxygen and 1.6 MAC I-653, isoflurane, or no anesthetic. Twenty-four hours after the last exposure, the rats were killed by administration of 100% carbon dioxide and then autopsied. Specimens were taken from brain, pituitary, lung, heart, duodenum, pancreas, kidney, and liver. No tissue damage attributable to either anesthetic was found nor was weight gain affected.
Department of Anesthesia, University of California, San Francisco 94143-0542.
E I
EI
Eger
B H
BH
Johnson
L D
LD
Ferrell
D000777:Anesthetics / Q000008:administration & dosage / Q000633:toxicity; D000818:Animals; D017610:Calcium Compounds; D000077335:Desflurane; D003890:Desiccation; D004355:Drug Stability; D005260:Female; D007530:Isoflurane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity*; D010087:Oxides; D051381:Rats; D012972:Sodium Hydroxide
D000777:Anesthetics; D017610:Calcium Compounds; D010087:Oxides; C004569:soda lime; D012972:Sodium Hydroxide; D000077335:Desflurane; D007530:Isoflurane