Inhibitory effect of acyclovir on the growth of Inoue-Melnick virus isolated from cerebrospinal fluid.
Inoue-Melnick virus (IMV) was isolated from the cerebrospinal fluid of patients with chronic neurologic disorders. The effect of acyclovir (ACV), 9-(2-hydroxyethoxymethyl)-guanine, on the growth of IMV was studied in human diploid cell cultures. ACV markedly inhibited the multiplication of all three IMV serotypes in vitro with the same inhibitory effect. By passage of IMV in the presence of ACV in the medium, ACV-resistant mutants of three IMV serotypes were easily isolated.
Nishibe
Y
Y
Inoue
Y K
YK
D000212:Acyclovir / Q000494:pharmacology*; D002460:Cell Line; D006801:Humans; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000382:microbiology*; D009187:Myelitis / Q000134:cerebrospinal fluid / Q000382:microbiology*; D009902:Optic Neuritis / Q000134:cerebrospinal fluid / Q000382:microbiology*; D012703:Serotyping; D013577:Syndrome; D014780:Viruses / Q000145:classification / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification
D000212:Acyclovir