Circadian rhythm in the light response of rat retinal disk-shedding and autophagy.
Under a light-dark cycle, disk-shedding and autophagy in the rat retina peak in the early and mid light phase, respectively. Under constant conditions, disk-shedding and autophagy responses after light stimulation were elicited at different time points of a 24-h cycle. The greatest magnitude of response occurred in the late dark and early light phase. Thus there is a circadian variation of the light response of important metabolic parameters in the mammalian retina. Inhibition of dopamine synthesis during the early light phase caused a significant dampening of the light responses of both disk-shedding and autophagy.
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Remé
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Wirz-Justice
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Rhyner
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Hofmann
D000818:Animals; D001343:Autophagy; D002940:Circadian Rhythm; D004298:Dopamine / Q000502:physiology*; D008027:Light; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D010786:Photoreceptor Cells / Q000502:physiology*; D051381:Rats; D011916:Rats, Inbred F344; D019805:alpha-Methyltyrosine
D008781:Methyltyrosines; D019805:alpha-Methyltyrosine; D004298:Dopamine