Effects of arterial ligation and embolization on pulmonary vascular pressure distribution.
The effects of embolization on the longitudinal distribution of pulmonary vascular pressures with respect to vascular compliance were determined by the vascular inflow and outflow occlusion technique in isolated blood-perfused pig lungs treated with papaverine to prevent vasomotor responses. Embolization with microspheres having mean diameters of 75, 200, and 550 microns and with barrier beads (2 X 3 X 3.5 mm) significantly increased the pressure gradient across the relatively compliant middle region (delta Pm) without increasing the gradients across the relatively noncompliant regions on the arterial (delta Pa) or venous (delta Pv) ends of the vasculature. In contrast ligation of several lobar arteries caused delta Pa to increase from 0.9 +/- 0.3 to 5.9 +/- 1.1 mmHg but did not change delta Pm or delta Pv. Assuming that delta Pa and delta Pv measured by vascular occlusion result from cessation of flow through resistances, these data suggest that in isolated pig lungs the vessels at the boundary between the arterial and middle regions defined by the occlusion technique are arteries greater than 2-3 mm diam and smaller than lobar arteries.
Department of Medicine, Johns Hopkins Medical Institutions at Francis Scott Key Medical Center, Baltimore, Maryland 21224.
M L
ML
Tod
M L
ML
McGeady
P
P
Rock
J T
JT
Sylvester
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D008026:Ligation; D008297:Male; D008863:Microspheres; D008955:Models, Cardiovascular; D010208:Papaverine / Q000494:pharmacology; D011651:Pulmonary Artery / Q000502:physiology*; D013552:Swine
D010208:Papaverine