Effects of nandrolone decanoate or testosterone decanoate on murine lupus: further evidence for a dissociation of autoimmunosuppressive and endocrine effects.
Nandrolone decanoate injections (20, 40 or 80 mg/kg/3 weeks) in female or castrated male New Zealand black/white mice, starting at various ages (4, 9, 17 or 26 weeks) prolong survival, reduce proteinuria and affect the weights of various endocrine and non-endocrine organs. Nandrolone decanoate is at least equally potent as testosterone decanoate with respect to its beneficial effects on lupus-associated symptoms; in contrast, its effects on some other androgen-sensitive endocrine parameters are significantly less. These observations show that the autoimmunosuppressive effects of steroids are not quantitatively correlated to endocrine properties.
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D000818:Animals; D004702:Endocrine Glands / Q000187:drug effects; D005260:Female; D005837:Genitalia, Male / Q000187:drug effects; D007165:Immunosuppression Therapy; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077603:Nandrolone Decanoate; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D011507:Proteinuria / Q000188:drug therapy; D013739:Testosterone / Q000031:analogs & derivatives* / Q000627:therapeutic use
D013739:Testosterone; D009277:Nandrolone; D000077603:Nandrolone Decanoate; C041677:testosterone decanoate