Release of corrosion products by F-75 cobalt base alloy in the rat. III: Effects of a carbon surface coating.
A pyrolytic carbon coating was applied to F-75 chromium-cobalt-molybdenum alloy in an effort to reduce the release of corrosion products in vivo. After intramuscular implantation in the rat, a complex pattern of serum and urine concentration elevations of chromium, cobalt, and nickel was seen. The carbon-coated implants released more chromium and cobalt than uncoated controls, as seen by significantly elevated metal concentrations in serum and urine. Animals receiving carbon-coated implants showed a high rate of recurrent implant site inflammation. Neoplastic infiltration of 24 animals with coated implants, but not in any of the 16 animals which received either uncoated F-75 microsphere or poly(ethylene) particulate implants.
Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia 19104.
J
J
Black
P
P
Oppenheimer
D M
DM
Morris
A M
AM
Peduto
C C
CC
Clark
D000497:Alloys / Q000032:analysis* / Q000633:toxicity; D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity; D001835:Body Weight / Q000187:drug effects; D002244:Carbon / Q000032:analysis* / Q000633:toxicity; D002857:Chromium / Q000032:analysis / Q000097:blood / Q000633:toxicity; D003035:Cobalt / Q000032:analysis* / Q000097:blood / Q000633:toxicity; D003343:Corrosion; D008168:Lung / Q000473:pathology; D008297:Male; D008863:Microspheres; D008982:Molybdenum / Q000032:analysis / Q000097:blood / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D000497:Alloys; D001672:Biocompatible Materials; D002857:Chromium; D003035:Cobalt; D002244:Carbon; D008982:Molybdenum