Magnetic resonance imaging of children with Duchenne muscular dystrophy.
Eight children representing a spectrum of clinical states of biopsy-proven Duchenne muscular dystrophy (DMD) underwent magnetic resonance (MR) scans to assess the degree of muscular involvement and disease progression. Five muscle groups (neck, shoulder girdle, pelvic girdle, thigh and calf) were evaluated. In each case, involved muscles were clearly demarcated. Image estimates of disease severity by degree of muscle involvement correlated well with clinical staging. In our experience MR is useful for assessment of disease stage, selection of appropriate muscles for biopsy and planning for courses of physical and rehabilitation therapy.
Schreiber
A
A
Department of Radiology, University of Iowa Hospitals, Iowa City.
Smith
W L
WL
Ionasescu
V
V
Zellweger
H
H
Franken
E A
EA
Dunn
V
V
Ehrhardt
J
J
D000273:Adipose Tissue / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008279:Magnetic Resonance Imaging; D009132:Muscles / Q000473:pathology; D009133:Muscular Atrophy / Q000473:pathology; D009136:Muscular Dystrophies / Q000473:pathology*; D011379:Prognosis