Subtle actions of 2-amino-4-phosphonobutyrate (APB) on the Off pathway in the mudpuppy retina.
The principal action of 2-amino-4-phosphonobutyrate (APB) applied to the retina is the elimination of the On-bipolar cell light response. In this study, we report that APB also has more subtle effects; it sometimes enhances Off responses of Off bipolar cells and On, Off, and On-Off inner retina neurons. Possible mechanisms for this enhancement are considered.
Department of Ophthalmology, Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110.
M S
MS
Arkin
R F
RF
Miller
D000200:Action Potentials / Q000187:drug effects; D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D008027:Light; D009337:Necturus; D012160:Retina / Q000187:drug effects* / Q000502:physiology
D000613:Aminobutyrates; C012729:2-amino-4-phosphonobutyric acid