The metabolism of t-butylcyclohexane in Fischer-344 male rats with hyaline droplet nephropathy.
The molecule t-butylcyclohexane is one of the first examples of a branched alkyl group attached to a hydrocarbon ring shown to be capable of producing renal damage at the corticomedullary junction of male rats. A metabolic study of t-butylcyclohexane yielded the following urinary metabolites: trans-4-t-butylcyclohexanol, 2c-hydroxy-4t-t-butylcyclohexanol, 2-methyl-2-cyclohexylpropanoic acid, 2c-hydroxy-4c-t-butylcyclohexanol, 2-methyl-2-cyclohexyl-1,3-propanediol, 2t-hydroxy-4t-t-butylcyclohexanol, and cis -4-t-butylcyclohexanol. As with other hydrocarbons of similar molecular weight that induce nephropathy in male rats, preferential sites of oxidative metabolism were observed that could potentially be related to the pathogenesis.
Henningsen
G M
GM
Harry G. Armstrong Aerospace Medical Research Laboratory, Wright-Patterson AFB, OH.
Yu
K O
KO
Salomon
R A
RA
Ferry
M J
MJ
Lopez
I
I
Roberts
J
J
Servè
M P
MP
D000818:Animals; D003510:Cyclohexanes / Q000378:metabolism*; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D008968:Molecular Conformation; D051381:Rats; D011916:Rats, Inbred F344; D013329:Structure-Activity Relationship
D003510:Cyclohexanes; C054362:tert-butylcyclohexane