Sulfolane-induced hypothermia enhances survivability in mice.
Mice injected intraperitoneally with sulfolane (tetrahydrothiophene-1,1-dioxide) underwent a significant decrease in metabolic rate and body temperature at ambient temperatures of 20 and 30 degrees C but not 35 degrees C. If given the opportunity, mice treated with sulfolane preferentially sought a cool ambient temperature. When given an LD50 dose of sulfolane (1270 mg/kg), the percentage mortality varied directly with ambient temperature. For example, at 35 degrees C mortality was 75% whereas at 25 degrees C mortality was only 8%. By undergoing an autonomically and behaviorally mediated decrease in body temperature (i.e., regulated hypothermia), sulfolane-treated mice appear to enhance their chance of survival.
Gordon
C J
CJ
Long
M D
MD
Fehlner
K S
KS
Dyer
R S
RS
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D007035:Hypothermia / Q000139:chemically induced; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011379:Prognosis; D012044:Regression Analysis; D013696:Temperature; D013876:Thiophenes / Q000494:pharmacology* / Q000633:toxicity
D013876:Thiophenes; C013693:sulfolane