Influence of prednisolone on antipyrine elimination in patients with obstructive lung disease.
The influence of prednisolone on the elimination of antipyrine has been investigated. The one-sample antipyrine clearance was estimated in 23 outpatients with obstructive lung disease before and after treatment with prednisolone 30 or 50 mg/day for 7 days. During prednisolone administration antipyrine clearance decreased from 54.9 +/- 14.8 to 51.7 +/- 14.6 ml/min (mean +/- SD; p less than 0.05). The results indicate that prednisolone decreases the rate of antipyrine elimination, but not to an extent suggesting a clinically important change in hepatic drug metabolism.
Medical Department F, Gentofte University Hospital, Hellerup, Denmark.
S
S
Loft
K
K
Simonsen
T
T
Evald
H R
HR
Christensen
J
J
Sonne
M
M
Døssing
D000983:Antipyrine / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008173:Lung Diseases, Obstructive / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011239:Prednisolone / Q000494:pharmacology*
D011239:Prednisolone; D000983:Antipyrine