Impact of azlocillin on the colon microflora.
To evaluate the impact of parenteral azlocillin therapy on human colon microflora, faecal specimens were taken from 6 patients before, during and after therapy for analysis of the microflora. In 2 patients major changes took place. Thus the numbers of streptococci, Escherichia coli, anaerobic cocci, lactobacilli, clostridia and bacteroides decreased markedly during therapy. One of these patients was colonized with azlocillin-resistant Enterobacter cloacae. The other 4 patients had only minor changes in the microflora. Variations between patients seem to exist. Pronounced alterations in the colonic flora may have clinical implications.
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D000328:Adult; D000368:Aged; D001390:Azlocillin / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects*; D003106:Colon / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D001390:Azlocillin