Malic enzyme response to triiodothyronine in the brain of neonatal rats.
Malic enzyme activity in the soluble fraction of the neonatal brain of hypothyroid rats was observed to be lowered as compared to that of the control animals (p less than 0.01). Administration of triiodothyronine to the neonates of control animals resulted in significant enhancement (p less than 0.001) in the activity of the Malic enzyme. Our studies show that brain malic enzyme which is involved in lipogenesis and hence in myelination responds to triiodothyronine in the early stage of life.
Thakare
U R
UR
Radiation Medicine Centre, Tata Memorial Centre, Parel, Bombay, India.
Vijayan
U
U
Sushila
L
L
Shah
D H
DH
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D007037:Hypothyroidism / Q000201:enzymology / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008291:Malate Dehydrogenase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D008291:Malate Dehydrogenase