Aztreonam penetration into synovial fluid and bone.
Eighteen patients with uncomplicated degenerative joint disease requiring joint replacement (hip or knee) were given a single 2-g intravenous dose of aztreonam over a 5-min period preoperatively. The mean concentration in synovial fluid of 83.0 +/- 9.2 micrograms/ml averaged 0.99 times the concomitant levels in serum. The mean concentration in cancellous bone of 16.0 +/- 4.3 micrograms/g averaged 0.20 times the concomitant levels in serum.
MacLeod
C M
CM
Bartley
E A
EA
Galante
J O
JO
Friedhoff
L T
LT
Dhruv
R
R
D000328:Adult; D000368:Aged; D001398:Aztreonam / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008875:Middle Aged; D013582:Synovial Fluid / Q000378:metabolism*
D001398:Aztreonam