Imaging of lymph node uptake after intravenous administration of indium-111 metalloporphyrins.
Indium-111- (111In) labeled tetra (N,N,N-trimethylanilinium) porphyrin (TTAP), tetra (N-methyl-4-pyridyl)porphyrin (TMPyP), and tetra(4-sulfonatophenyl)porphyrin (T4SPP) were synthesized and lymph node uptake was measured in animals after intravenous administration. In rats [111In] TTAP had maximum lymph node to muscle uptake ratios which averaged 85:1 between 24 and 48 hr postinjection. Total lymph node uptake was nearly 1% at that time. Lymph nodes in rabbits were clearly visualized by gamma scintigraphy at 48 hr after i.v. injection of labeled TTAP. These results suggest that 111In-labeled TTAP may be a prototype for the development of a class radiopharmaceuticals which permits visualization of lymph nodes after i.v. administration.
G D
GD
Robinson
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A
Alavi
R
R
Vaum
M
M
Staum
D000818:Animals; D007204:Indium; D007275:Injections, Intravenous; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008297:Male; D008652:Mesoporphyrins; D008665:Metalloporphyrins / Q000378:metabolism; D011166:Porphyrins; D011817:Rabbits; D011868:Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D008652:Mesoporphyrins; D008665:Metalloporphyrins; D011166:Porphyrins; D011868:Radioisotopes; D007204:Indium; C016136:tetraphenylporphine sulfonate; C021096:tetra(4-N-methylpyridyl)porphine; C029972:alpha,beta,gamma,delta-tetrakis(4-N-trimethylaminophenyl)porphine