Protein-bound homocyst(e)ine. A possible risk factor for coronary artery disease.
The development of atherosclerotic changes and thromboembolism are common features in homocystinurics. Hence, we postulate a positive correlation between the level of homocyst(e)ine in the blood and the occurrence of coronary artery disease. Homocysteine is found either as free homocystine, cysteine-homocysteine mixed disulfide, or protein-bound homocyst(e)ine. In nonhomocystinuric subjects, most homocysteine molecules are detectable in the protein-bound form. Thus, protein-bound homocyst(e)ine in stored plasma which reflected total plasma homocyst(e)ine was determined in 241 patients with coronary artery disease (173 males and 68 females). The mean +/- SD total plasma homocyst(e)ine was 5.41 +/- 1.62 nmol/ml in male patients, 4.37 +/- 1.09 nmol/ml in male controls, 5.66 +/- 1.93 nmol/ml in female patients, and 4.16 +/- 1.62 nmol/ml in female controls. The differences between the patients with coronary artery disease and the controls were statistically significant (P less than 0.0005).
Kang
S S
SS
Wong
P W
PW
Cook
H Y
HY
Norusis
M
M
Messer
J V
JV
D000328:Adult; D000367:Age Factors; D000368:Aged; D001798:Blood Proteins / Q000378:metabolism*; D003327:Coronary Disease / Q000209:etiology*; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006711:Homocystine / Q000097:blood*; D006801:Humans; D008297:Male; D008593:Menopause; D008875:Middle Aged; D011485:Protein Binding; D012306:Risk; D012737:Sex Factors
D001798:Blood Proteins; D006710:Homocysteine; D006711:Homocystine