[Ifosfamide treatment for children with malignant tumor].
Seven drugs were administered to nude mice with transplanted TNB9 neuroblastoma. DTIC, cyclophosphamide and ifosfamide were the first-line drugs against TNB9. Chemotherapy including ifosfamide was effective to three of six children with malignant solid tumor resistant to cisplatin and/or cyclophosphamide. Two of the patients who were pretreated with radiotherapy were found to have hemorrhagic cystitis after ifosfamide administration. It therefore seems that chemotherapy with ifosfamide should be withheld after radiotherapy.
Dept. of Pediatrics, Jichi Medical School.
H
H
Muchi
Y
Y
Taniguchi
S
S
Makino
D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy*; D009447:Neuroblastoma / Q000188:drug therapy; D014183:Transplantation, Heterologous
D007069:Ifosfamide