Thiazide-induced hyponatremia: an unusual neurologic course.
We have presented a case of thiazide-induced hyponatremia that followed an unusual course after the patient, suffering from extreme lethargy, was admitted with a serum sodium concentration of 104 mEq/L. Although the electrolyte imbalance was essentially corrected within 20 hours and there was clinical improvement, three days later the patient suddenly lost consciousness. She was comatose for more than a month, apparently from extrapontine myelinolysis. After a dramatic improvement, the patient was discharged with almost no neurologic deficit.
Mozes
B
B
Pines
A
A
Werner
D
D
Olchovsky
D
D
Lieberman
P
P
Frankl
O
O
D000208:Acute Disease; D001929:Brain Edema / Q000139:chemically induced*; D002752:Chlorthalidone / Q000009:adverse effects*; D003128:Coma / Q000139:chemically induced; D003711:Demyelinating Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced; D007010:Hyponatremia / Q000139:chemically induced*; D008875:Middle Aged
D002752:Chlorthalidone