[Measuring cis-dichlorodiamino platinum(II) concentrations in human blood and mouth mucosa].
Using the method of atomic absorption spectroscopy, platinum (DDP) concentrations were determined in tissue samples and plasma from 10 patients who suffered from a squamous cell carcinoma and were receiving cis-platinum. The drug was administered by a rapid infusion (60 mg/m2). Tissue samples and plasma were collected 5 h after infusion. Platinum concentrations found in squamous cells of the oral cavity varied from 3 to 20 micrograms/g with a median concentration of 7.5 micrograms/g. The corresponding plasma concentrations were 1.5-2.5 micrograms/ml. The data suggest that within 5 h after infusion an enrichment of cis-platinum takes place in human tissue.
HNO-Universitätsklinik, Frankfurt/Main.
A
A
Klima
G
G
Haas
G
G
Oremek
D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D007262:Infusions, Intravenous; D009061:Mouth Mucosa / Q000378:metabolism*; D009959:Oropharyngeal Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D009960:Oropharynx / Q000378:metabolism; D010610:Pharyngeal Neoplasms / Q000378:metabolism*
D002945:Cisplatin
Messungen von Cis-Dichlorodiamino-Platin (II) Konzentrationen in Plasma und Mundschleimhaut des Menschen.