Acute psychosis in a woman with a prolactinoma.
Changes in dopaminergic activity were inferred in a woman with a known prolactinoma several months prior to an acute psychotic episode. Serum prolactin levels reflected central dopaminergic activity, since both the endocrinologic regulation of prolactinomas and the pathophysiology of acute psychosis have been linked to alterations in dopaminergic activity. Serum prolactin levels fell approximately four months prior to onset of the psychotic episode and thus may have provided a predictive indicator of changing dopamine activity in both the tubero-infundibular and the mesolimbic-mesocortical dopaminergic systems.
University of Arizona College of Medicine, Tucson.
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Sandyk
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Bergsneider
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Iacono
D000328:Adult; D005260:Female; D006801:Humans; D010911:Pituitary Neoplasms / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D011388:Prolactin / Q000378:metabolism*; D012559:Schizophrenia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology
D011388:Prolactin