Reversal of ethylene glycol-induced nephrotoxicosis in a dog.
Ethylene glycol-induced nephrotoxicosis was diagnosed in a dog with acute renal failure. Histologically, the dog had proximal tubular degeneration and necrosis, intraluminal calcium oxalate crystals, generally intact tubular basement membranes, and evidence of tubular regeneration. After 20 days of peritoneal dialysis and diuresis, renal function was adequate to maintain homeostasis without supportive care. Nine weeks after onset of the ethylene glycol-induced renal failure, the dog's kidneys were histologically and functionally normal.
Department of Medical Sciences, Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
L E
LE
Fox
G F
GF
Grauer
R R
RR
Dubielzig
D E
DE
Bjorling
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D004285:Dogs; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000506:poisoning*; D008297:Male; D010530:Peritoneal Dialysis / Q000662:veterinary
D005026:Ethylene Glycols; D019855:Ethylene Glycol