[Effect of vitamin A on the endogenous synthesis and system of N-nitrosodimethylamine detoxication in the rat liver].
The administration of N-nitrosodimethylamine (NDMA) and its endogenic synthesis from amidopyrine and sodium nitrite decreases in the liver the level of reduced glutathione, ascorbic acid, glutathione reductase and glutathione-S-transferase activities, the accumulation of oxidized glutathione as well as the damage of DNA. The gamma-glutamyltransferase activity, the marker of carcinogenesis, increased. The damaging action of NDMA under the influence of vitamin A deficiency increased, but the vitamin excess decreased the biochemical changes in the liver.
A A
AA
Pentiuk
V M
VM
Mikhaĭlenko
B L
BL
Rubenchik
N B
NB
Lutsiuk
R
R
Khadur
D000818:Animals; D004249:DNA Damage; D004277:DNA, Single-Stranded / Q000187:drug effects; D004128:Dimethylnitrosamine / Q000493:pharmacokinetics / Q000633:toxicity*; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D014801:Vitamin A / Q000494:pharmacology*; D014802:Vitamin A Deficiency / Q000378:metabolism
D004277:DNA, Single-Stranded; D014801:Vitamin A; D004128:Dimethylnitrosamine
Vliianie vitamina A na éndogennyĭ sintez i sistemu detoksikatsii N-nitrozodimetilamina v pecheni krys.