Penetration of ciclacillin into bronchial secretions.
The penetration of ciclacillin into bronchial secretions was investigated in 105 patients undergoing bronchoscopy after a single oral dose of 500 mg ciclacillin. Comparison was made with 26 patients who received 500 mg ampicillin by mouth. Over a 6 to 8 hour period, ciclacillin achieved significantly higher levels in bronchial secretions but no statistically significant difference between serum ampicillin and ciclacillin levels was detected.
Bone
M
M
Symonds
J
J
Dougan
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism; D001980:Bronchi / Q000378:metabolism*; D001999:Bronchoscopy; D003493:Cyclacillin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010406:Penicillins / Q000378:metabolism*; D013183:Sputum / Q000378:metabolism*
D010406:Penicillins; D003493:Cyclacillin; D000667:Ampicillin