Analogs of oxytocin containing a modified peptide bond.
Analogs of deamino-oxytocin and deamino-oxypressin containing a CH2-NH group instead of an amide bond between positions 8 and 9 were synthesized. All tested compounds exhibit significantly lowered biological activities.
Department of Chemistry, University of Arizona, Tucson.
M
M
Lebl
E E
EE
Sugg
G
G
van Binst
P
P
Vander Elst
D
D
Tourwé
J
J
Slaninová
V J
VJ
Hruby
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005260:Female; D010121:Oxytocin / Q000031:analogs & derivatives*; D051381:Rats; D013329:Structure-Activity Relationship; D014599:Uterus / Q000187:drug effects
D010121:Oxytocin