Radionuclide imaging of epithelial ovarian tumours with 123I-labelled monoclonal antibody (H317) specific for placental-type alkaline phosphatase.
A murine monoclonal antibody, H317, specific for placental-type alkaline phosphatase was labelled with 123I and assessed as an imaging agent using a gamma camera computer system in 18 patients suspected of possible recurrent or metastatic ovarian cancer 1-4 years after removal of the primary tumour. Four patterns of distribution were visible: (1) normal uptake; (2) focal accumulation; (3) diffuse uptake; and (4) 'cold' areas. Six patients, five of whom were clinically negative for ovarian cancer, had normal scans; 11 patients, eight of whom were clinically positive, had increased uptake. One patient had visibly 'cold' areas. Findings were confirmed, where possible, at surgery.
Critchley
M
M
Brownless
S
S
Patten
M
M
McLaughlin
P J
PJ
Tromans
P M
PM
McDicken
I W
IW
Johnson
P M
PM
D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000276:immunology*; D000911:Antibodies, Monoclonal; D002277:Carcinoma / Q000201:enzymology; D005260:Female; D058851:GPI-Linked Proteins; D006801:Humans; D007457:Iodine Radioisotopes; D007527:Isoenzymes / Q000276:immunology*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000201:enzymology; D011877:Radionuclide Imaging
D000911:Antibodies, Monoclonal; D058851:GPI-Linked Proteins; D007457:Iodine Radioisotopes; D007527:Isoenzymes; D000469:Alkaline Phosphatase; C019839:alkaline phosphatase, placental