Rapid measurement of serum water to assess pseudohyponatremia.
Pseudohyponatremia is caused by an increased serum protein or lipid concentration producing a "space-occupying lesion" in serum water. Its presence and magnitude must be assessed in hyponatremic patients with, for example, paraproteinemia or hyperlipemic diabetic coma. In the absence of a direct-reading ion-selective electrode system, a method for measuring the water content of serum is required. We describe two rapid methods for measuring the diffusible water of serum: osmometry before and after dilution and chloride measurement before and after ultrafiltration. Either of these methods allows the true sodium status of a patient's serum to be determined.
Faye
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S
Payne
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RB
D001774:Blood Chemical Analysis; D001834:Body Water / Q000032:analysis*; D002712:Chlorides; D004566:Electrodes; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism; D006951:Hyperlipoproteinemias / Q000378:metabolism; D007010:Hyponatremia / Q000175:diagnosis* / Q000378:metabolism; D009994:Osmolar Concentration; D012964:Sodium / Q000097:blood; D014462:Ultrafiltration
D002712:Chlorides; D012964:Sodium