Behavioral function of GABA in the median raphe nucleus.
Locomotor hyperactivity of rats was induced by injection of muscimol into the median raphe nucleus. Intra-raphe injection of picrotoxin or bicuculline failed to influence locomotor activity, however, muscimol-induced hyperactivity was inhibited by simultaneous intra-raphe injection of picrotoxin and muscimol. These data indicate an involvement of the GABAergic system in the median raphe nucleus in induction of locomotor effects. Systemic and intra-raphe injection of cyproheptadine depressed muscimol-induced hypermotility, whereas lesion of serotonergic raphe neurons by 5,7-DHT or intra-raphe injected LSD did not influence the muscimol effect, suggesting that GABAergically induced locomotor effects are not entirely mediated by serotonergic mechanisms.
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D000818:Animals; D001640:Bicuculline / Q000031:analogs & derivatives / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D013196:Dihydrotestosterone / Q000494:pharmacology; D018756:GABA Antagonists; D006220:Haloperidol / Q000494:pharmacology; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009118:Muscimol / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D001640:Bicuculline; D003533:Cyproheptadine; D013196:Dihydrotestosterone; D018756:GABA Antagonists; D006220:Haloperidol; D008238:Lysergic Acid Diethylamide; D009118:Muscimol; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid; C017069:bicuculline methiodide