[N-substituted p-fluorobenzencarboxyamides. Evaluation of the in vitro antimicrobial activity].
As part of our investigations on fluorine containing compounds of potential pharmacological interest, a series of N-substituted p-fluorobenzencarboxyamides, analogs of previously studied p-fluorobenzensolfonamides, was prepared. The in vitro antibacterial and antimycotic properties were also assayed. The replacement of the sulfonamide group with an isosteric carboxyamide one, was found to confer to trifluoromethylsubstituted compounds good activity against some strains of yeasts (Candida) and hyphomycetes (Tricophyton, Aspergillus, Microsporum, Epidermophyton). These compounds however are not very active against the gram-positive and gram-negative bacteria on which the corresponding sulfonanilides showed significant activity.
Vigorita
M G
MG
Saporito
G
G
Previtera
T
T
Pizzimenti
F C
FC
Bisignano
G
G
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis; D001419:Bacteria / Q000187:drug effects*; D001549:Benzamides / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005464:Fluorobenzenes / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D001549:Benzamides; D005464:Fluorobenzenes
p-Fluorobenzencarbossiamide N-sostituite. Valutazione dell'attività antimicrobica in vitro.