[Development of carcinoma of Vater's ampulla in an adenoma. Analysis of a personal case load and review of the literature].
A retrospective analysis was undertaken of our case material of 40 histological preparations of carcinoma of the ampulla of Vater, as well as a survey of the literature of 103 adenomas of the ampulla of Vater. Signs of malignant transformation were detected in 25% of the adenomas, whilst adenomatous residues were identified in 72% of the examined carcinomas of the ampulla of Vater. Thus, an adenoma-carcinoma sequence seems to be as significant in the case of Vater's papilla as in the colo-rectal region. An epidemiological investigation confirms this hypothesis since 1. adenomas of the papilla Vateri develop 4 years prior to a carcinoma and 2. the relative sex distribution of the two diseases is approximately equal.
Sellner
F
F
Machacek
E
E
D000236:Adenoma / Q000473:pathology*; D014670:Ampulla of Vater / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003138:Common Bile Duct Neoplasms / Q000473:pathology*; D005260:Female; D005736:Gardner Syndrome / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D011127:Polyps / Q000473:pathology
Zur Entstehung der Karzinome der Papilla Vateri über eine Adenom-Karzinom-Sequenz. Eine Analyse des eigenen Krankengutes und eine Literaturübersicht.