The effect of composite oral treatment for internal contamination with several radionuclides on 131I thyroid uptake in humans.
The efficiency of a composite oral treatment on 131I thyroid uptake was investigated in three adult volunteers. The treatment consisted of 10 g of calcium alginate, 3 g ferrihexacyanoferrate(II), 130 mg of potassium iodide and 5 g of Zn-DTPA. This mixture when administered 30 min before 131I almost completely blocked the 131I thyroid uptake. This indicates that simultaneous administration of other antidotal agents do not cancel or decrease the effect of potassium iodide on 131I thyroid uptake. The finding deserves attention since composite oral treatment is the recommended therapy in cases of accidental environmental exposure to several radionuclides.
Simonović
I
I
Kargacin
B
B
Kostial
K
K
D000284:Administration, Oral; D000328:Adult; D000464:Alginates / Q000494:pharmacology; D000931:Antidotes / Q000494:pharmacology*; D004781:Environmental Exposure; D005295:Ferrocyanides / Q000494:pharmacology; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006801:Humans; D007457:Iodine Radioisotopes / Q000378:metabolism*; D004369:Pentetic Acid / Q000494:pharmacology; D011193:Potassium Iodide / Q000494:pharmacology; D013961:Thyroid Gland / Q000378:metabolism*
D000464:Alginates; D000931:Antidotes; D005295:Ferrocyanides; D006603:Hexuronic Acids; D007457:Iodine Radioisotopes; D011193:Potassium Iodide; D004369:Pentetic Acid; D020723:Glucuronic Acid; C000170:ferric ferrocyanide