[Lysosomotropic agents as regulators of the activity of lysosomal hydrolases].
Activities of lysosomal enzymes acid phosphatase, N-acetyl-beta-D-glucosaminidase, beta-galactosidase, acid lipase and cathepsins B and D were studied after accumulation of neutral red, acridine orange chloroquine and daunorubicin in lysosomes of fibroblasts of the LSM substrain. All the drugs studied proved to be inhibitors of these enzymes except of daunorubicin, which stimulated acid lipase activity. Lysosomotropic drugs are considered as possible regulators of the activity of lysosomes.
Bulychev
A G
AG
Assinovskaia
O A
OA
Semenova
E G
EG
D000165:Acridine Orange / Q000493:pharmacokinetics / Q000494:pharmacology; D002460:Cell Line; D002738:Chloroquine / Q000493:pharmacokinetics / Q000494:pharmacology; D003630:Daunorubicin / Q000493:pharmacokinetics / Q000494:pharmacology; D005347:Fibroblasts / Q000201:enzymology; D006801:Humans; D006867:Hydrolases / Q000037:antagonists & inhibitors*; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D009499:Neutral Red / Q000493:pharmacokinetics / Q000494:pharmacology
D009499:Neutral Red; D002738:Chloroquine; D006867:Hydrolases; D000165:Acridine Orange; D003630:Daunorubicin
Lizosomotropnye agenty kak reguliatory aktivnosti lizosomnykh gidrolaz.