Observations of cell function and morphology in the presence of silicone gel: an in vitro study.
The project described in this article used in vitro tissue culture techniques and flow cytometry to determine if there are alterations in cell morphology in those cells that have been placed in contact with a commercially available medical-grade silicone gel used in mammary implants. We were unable to demonstrate significant changes in cell cycle characteristics following in vitro exposure for 1 to 12 days using human fibroblasts, mouse fibroblasts, and Chinese hamster ovary cells.
Cocke
W M
WM
Department of Surgery, Texas A & M University College of Medicine, College Station 77843.
Sampson
H W
HW
Quarles
J M
JM
D000818:Animals; D001940:Breast / Q000601:surgery*; D002453:Cell Cycle / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000187:drug effects; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D051379:Mice; D011003:Ploidies; D019736:Prostheses and Implants; D012828:Silicones / Q000633:toxicity*
D012828:Silicones; D004247:DNA