[Inhibin activity of the organs of the male reproductive system in rats treated with dihydrotestosterone].
The content of protein hormone, inhibin, in the rat testis and prostate has been studied on preadolescent female mice. Both organs were characterized by a certain inhibin activity, it being higher in the prostate. A single injection of 25 mu kg dihydrotestosterone (DHT) to rats has been followed by the increase in testicular and prostate mass, elevation of 17 alpha-hydroxyprogesterone and testosterone levels in peripheral blood, and a slight rise in inhibin testicular activity, with the lack of these changes in the prostate. The detection of inhibin in the prostate confirms possible direct link of the organ with the pituitary body. DHT effect on spermatogenesis has been but insignificantly related to FSH depression.
Gladkova
A I
AI
D000818:Animals; D013196:Dihydrotestosterone / Q000494:pharmacology*; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects; D005837:Genitalia, Male / Q000187:drug effects* / Q000378:metabolism; D007265:Inhibins / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects*; D014020:Tissue Extracts / Q000494:pharmacology
D014020:Tissue Extracts; D013196:Dihydrotestosterone; D007265:Inhibins
Aktivnost' ingibina organov muzhskoĭ reproduktivnoĭ sistemy krys v usloviiakh obrabotki digidrotestosteronom.