Induction of Sertoli cell tumors in the rat ovary by N-alkyl-N-nitrosoureas.
Relatively high incidences of Sertoli cell tumors of the ovary were induced in Donryu rats given a 400 ppm N-ethyl-N-nitrosourea solution as drinking water for 4 weeks or a single dose of 200 mg/kg N-propyl-N-nitrosourea by stomach tube. Typical Sertoli cell tumors were composed of solid areas showing tubular formation. Tubules were lined by tall, columnar cells having abundant, faintly eosinophilic, often vacuolated cytoplasm, and basally oriented round nuclei. In some cases, Sertoli cell tumors were found to be mixed with granulosa cell tumors.
A
A
Maekawa
H
H
Onodera
H
H
Tanigawa
J
J
Kanno
K
K
Furuta
Y
Y
Hayashi
D000818:Animals; D005038:Ethylnitrosourea / Q000633:toxicity; D005260:Female; D006106:Granulosa Cell Tumor / Q000139:chemically induced / Q000401:mortality / Q000473:pathology; D009607:Nitrosourea Compounds / Q000633:toxicity*; D010051:Ovarian Neoplasms / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology; D010653:Phenylbutazone / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012707:Sertoli Cell Tumor / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology; D013997:Time Factors
D009607:Nitrosourea Compounds; C020796:propylnitrosourea; D010653:Phenylbutazone; D005038:Ethylnitrosourea