Aliphatic chain saturation and polar region influence amphiphile effects on sarcoplasmic reticulum calcium sequestration.
Calcium sequestration by skeletal muscle sarcoplasmic reticulum vesicles was enhanced by the addition of C18 saturated fatty acid to the reaction, while the cis-monounsaturated fatty acid and corresponding amine were potent inhibitors. The effects of these amphiphiles were found to depend on the degree of aliphatic chain saturation, the nature of the polar group, and the ratio of amphiphile:membrane phospholipid present in the reaction.
Rathier
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Chen
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Messineo
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D000588:Amines / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002451:Cell Compartmentation / Q000187:drug effects; D005227:Fatty Acids / Q000378:metabolism / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism / Q000494:pharmacology; D005233:Fatty Alcohols / Q000378:metabolism / Q000494:pharmacology*; D066298:In Vitro Techniques; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism; D012995:Solubility; D013329:Structure-Activity Relationship
D000588:Amines; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D005233:Fatty Alcohols; D002118:Calcium