Preparation of the individual diastereomers of adenylyl-(2'-5')-P-thioadenylyl-(2'-5')-adenosine and their 5'-phosphorylated derivatives.
The individual diastereomers of trimer A2'p5'A2'p(s)5'A, containing one phosphorothioate linkage, were prepared via a modified hydroxybenzotriazole phosphotriester approach. The 5'-phosphorylated derivatives of the latter compounds were obtained after phosphorylation with a 6-trifluoromethyl-1-benzotriazolyl activated phosphoromorpholidate.
de Vroom
E
E
Gorlaeus Laboratory, Leiden, The Netherlands.
Fidder
A
A
Saris
C P
CP
van der Marel
G A
GA
van Boom
J H
JH
D000227:Adenine Nucleotides / Q000138:chemical synthesis*; D003432:Cross-Linking Reagents; D009690:Nucleic Acid Conformation; D009843:Oligoribonucleotides / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D010766:Phosphorylation; D013237:Stereoisomerism
D000227:Adenine Nucleotides; D003432:Cross-Linking Reagents; D009843:Oligoribonucleotides; C023505:2',5'-oligoadenylate