Inhibition of esterase activity and an undercounting of circulating monocytes in a population of production workers.
A cross-sectional review of routine employee health status examinations has identified an undercounting of circulating monocytes associated with an inhibition of a surface monocyte esterase, alpha-naphthyl butyrate esterase. It is postulated that this inhibition is associated with an organophosphate used in the production process. Correlation with routine measures of health status are presented.
Levine
M S
MS
Fox
N L
NL
Thompson
B
B
Taylor
W
W
Darlington
A C
AC
Van der Hoeden
J
J
Emmett
E A
EA
Rutten
W
W
D000328:Adult; D002802:Cholinesterases / Q000097:blood; D003864:Depression, Chemical; D004950:Esterases / Q000097:blood*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D007970:Leukopenia / Q000209:etiology*; D008297:Male; D009000:Monocytes / Q000201:enzymology*; D009284:Naphthols / Q000097:blood; D009784:Occupational Diseases / Q000209:etiology*; D009943:Organophosphorus Compounds / Q000009:adverse effects*
D009284:Naphthols; D009943:Organophosphorus Compounds; C029204:alpha-naphthyl butyrate; D004950:Esterases; D002802:Cholinesterases