[Pharmacokinetic characteristics of the antibiotics comprising antimicrobial biocompatible conjunctive elements for the internal organs].
It was found during the study of pharmacokinetics of gentamycin and cephamesine being constituents of antimicrobial conjunctive elements for the internal organs that in the process of diffusion of the antibiotics from the polymer film gentamycin level in the organism increased by the 1st day of observation and cephamesine level by the 3rd day. Thereafter their concentrations decreased by the 7th and 10th days, respectively. The depot of the antibiotics is created at the site of the film application, and their highest concentrations occurring in the periods dangerous for the development of postoperative inflammatory complications exceed the minimal suppressive concentrations with regard to their main causative agents. It is advisable to use antimicrobial conjunctive elements with the given antibiotics for prevention of postoperative inflammatory complications following cesarean section.
Sidorova
I S
IS
Makarov
I O
IO
Vasina
T A
TA
Botvin
M A
MA
D000042:Absorption; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001672:Biocompatible Materials / Q000493:pharmacokinetics*; D002437:Cefazolin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002585:Cesarean Section; D004058:Diffusion; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011109:Polymethacrylic Acids; D011205:Povidone / Q000031:analogs & derivatives; D011247:Pregnancy; D051381:Rats; D013530:Surgical Wound Infection / Q000517:prevention & control; D013537:Sutures; D013997:Time Factors
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D005839:Gentamicins; D011109:Polymethacrylic Acids; C054377:butyl methacrylate-vinylpyrrolidone copolymer; D011205:Povidone; D002437:Cefazolin
Osobennosti farmakokinetiki antibiotikov, vkhodiashchikh v sostav antimikrobnykh biosovmestimykh soedinitel'nykh élementov dlia vnutrennikh organov.