Vitamin E effect on symptoms and laboratory values in the elderly.
The effect of vitamin E use on selected medical disorders and laboratory parameters was studied in a large ambulatory elderly population. Information obtained from a standardized questionnaire concerning reports of numerous clinical disorders, such as hypertension, fatigue, and vaginal bleeding, was used to determine whether the use of vitamin E predisposed to those conditions. During a 2-year period, information was available on 369 vitamin E users and 1,861 non-users. No differences were noted in the prevalence of reported clinical disorders between the two groups, except that men using vitamin E complained more often of shortness of breath (p less than .04) and angina (p less than .03). There were no significant differences between vitamin E users and controls in any hematologic parameters studied. After the groups had been adjusted for age and sex differences, only one biochemical parameter, serum glutamic-oxaloacetic transaminase (SGOT) in men, was found to be significantly different in vitamin E users as compared with controls. Use of vitamin E by the participants in this study appeared to have little influence on clinical disorders or hematologic or biochemical parameters.
W E
WE
Hale
L L
LL
Perkins
F E
FE
May
R G
RG
Marks
R B
RB
Stewart
D000368:Aged; D001219:Aspartate Aminotransferases / Q000097:blood; D019411:Clinical Laboratory Techniques; D003951:Diagnostic Errors; D004363:Drug Utilization; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening; D009017:Morbidity; D012737:Sex Factors; D014810:Vitamin E / Q000009:adverse effects*
D014810:Vitamin E; D001219:Aspartate Aminotransferases