In vitro effects of monobactams on Legionella pneumophila.
The effects of azthreonam and carumonam against Legionella pneumophila Philadelphia-1 strain in liquid medium and in phagocytic cells were examined. The minimum inhibitory concentration (MIC) of azthreonam for the bacteria was 12.5 micrograms/ml at a concentration of 1.4 X 10(4) colony forming units (CFU) and 25 micrograms/ml at a concentration of 1.4 X 10(5) CFU. MIC of carumonam was 25 micrograms/ml in both concentrations of the bacterial suspension. In guinea pig macrophages, both azthreonam and carumonam at a concentration of 100 micrograms/ml did not inhibit the multiplication of the bacteria.
Yoshida
S
S
Department of Microbiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Mizuguchi
Y
Y
Nikaido
Y
Y
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001398:Aztreonam / Q000494:pharmacology* / Q000031:analogs & derivatives; D006168:Guinea Pigs; D007875:Legionella / Q000187:drug effects* / Q000502:physiology; D008264:Macrophages / Q000382:microbiology; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; C044145:carumonam; D001398:Aztreonam