Synthesis of three NH2-terminally extended arginine-vasopressins with prolonged biological activities.
The synthesis of three novel AVP-analogues, extended by 1-3 amino acids at their NH2-2-termini in accordance with the sequence of the bovine arginine-vasopressin neurophysin II precursor, is reported. The compounds were assayed for their antidiuretic and vasopressor activities with particular attention to the duration of the effects. All compounds showed high potency, based on the intensity, and prolonged effects in both test systems compared with AVP.
Lammek
B
B
Institute of Chemistry, University of Gdansk, Poland.
Rekowski
P
P
Kupryszewski
G
G
Melin
P
P
Ragnarsson
U
U
D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004231:Diuresis / Q000187:drug effects; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains
D001127:Arginine Vasopressin