Effects of phthalic acid esters (PAEs) on the neonate and aspects of teratogenic actions.
A review of the literature reveals that several different phthalic acid esters (PAEs) are capable of causing testicular damage. Phthalate-induced zinc deficiency is consistent with germinal epithelial damage. Among experimental animals, mice perhaps show the greatest sensitivity to phthalate-induced terata, but high doses/exposure are required. Little toxicologic information is available with regard to phthalate-induced effects upon the neonate.
Thomas
J A
JA
Wienckowski
D B
DB
Gillies
B A
BA
Thomas
M J
MJ
Youkilis
E J
EJ
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects; D006224:Cricetinae; D005260:Female; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010795:Phthalic Acids / Q000633:toxicity*; D010968:Plasticizers / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D013723:Teratogens; D013737:Testis / Q000187:drug effects*
D010795:Phthalic Acids; D010968:Plasticizers; D013723:Teratogens