Trazodone: a simple, clean extraction and rapid quantification by high pressure liquid chromatography.
We have developed an HPLC technique which is precise, rapid and reliable. Sample preparation involves simple alkaline extraction into an organic solvent mixture. Trazodone elutes at 3.2 min in this reverse phase system. There is no requirement for elevated column temperature. The method is linear to 3000 ng/ml. The availability of a technique which is transferrable to the clinical laboratory may help to define the proper role of therapeutic monitoring of trazodone.
Gerson
B
B
Chan
S
S
Bell
F
F
Pappalardo
K M
KM
D002707:Chlordiazepoxide / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003975:Diazepam / Q000097:blood; D006801:Humans; D008012:Lidocaine / Q000097:blood; D014196:Trazodone / Q000097:blood*
D002707:Chlordiazepoxide; D008012:Lidocaine; D003975:Diazepam; D014196:Trazodone