The development and distribution of alpha-bungarotoxin binding sites in rat tectal transplants.
The development and distribution of alpha-bungarotoxin (alpha-BTX) binding sites in tectal grafts was examined autoradiographically using the radioligand [125I]-alpha-BTX. High alpha-BTX binding was observed in localized areas within grafts; these areas corresponded to regions which contained high acetylcholinesterase activity and received retinal input. Receptor differentiation also occurred in the absence of specific host afferents. The graft data show that, as in normal superior colliculus, development of high alpha-BTX binding is limited to areas containing presumptive superficial layer cells.
Department of Anatomy and Human Biology, University of Western Australia, Nedlands.
M M
MM
Tan
A R
AR
Harvey
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D002038:Bungarotoxins / Q000378:metabolism*; D007457:Iodine Radioisotopes; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011950:Receptors, Cholinergic / Q000378:metabolism*; D011978:Receptors, Nicotinic; D013477:Superior Colliculi / Q000196:embryology / Q000378:metabolism / Q000637:transplantation*; D064569:alpha7 Nicotinic Acetylcholine Receptor
D002038:Bungarotoxins; C579167:Chrna7 protein, human; C579165:Chrna7 protein, rat; D007457:Iodine Radioisotopes; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor; D000110:Acetylcholinesterase