Effects of acute 1,1,1-trichloroethane inhalation on aortic nerve impulse and blood pressure.
Effects of 1,1,1-trichloroethane (1,1,1-TCE) inhalation on the afferent impulse of the aortic nerve and aortic blood pressure were investigated in anesthetized dogs. In acute inhalation experiment, the threshold concentration of 1,1,1-TCE required to produce a decrease in the aortic nerve activity was approximately 0.4% in inspired air. Moreover, this threshold level and the threshold concentration required to produce a decrease in aortic blood pressure were identical in value. The aortic nerve activity obviously decreased and at the same time was accompanied by a marked decrease in aortic blood pressure following inhalation of high 1,1,1-TCE concentration. These results suggest that the afferent pathway of aortic baroreflex may be operated at a concentration of more than 0.4% in inspired air. It is further suggested that baroreceptor reflex plays a major role in the control of arterial blood pressure following acute 1,1,1-TCE inhalation in anesthetized dogs.
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Kobayashi
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Hobara
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Sakai
D000200:Action Potentials / Q000187:drug effects*; D000818:Animals; D001011:Aorta / Q000294:innervation* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D005260:Female; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects; D012119:Respiration; D014240:Trichloroethanes / Q000008:administration & dosage
D014240:Trichloroethanes; C024566:1,1,1-trichloroethane