Presence of atherosclerotic lesions connected with the coronary artery lumen.
Starting from five accidental observations made on isolated tissue sections on the existence of "anchored" lesions in the coronary arteries of adolescents and young adults, 47 selected coronary artery samples removed from subjects 16-40 years old were submitted to a three-dimensional investigation. Based on serial sections and sequential camera lucida drawings, the geometry, diameters and spatial connections of 42 intimal necrotic areas were recorded. All these lesions appeared in a three-dimensional plane connected with the coronary artery lumen by one or several necrotic bands which seemed to communicate freely with the luminal cavity. The role of "anchored" lesions of young subjects as precursors of lipid-rich centers of fibronecrotic plaques of mature adults and elderly people is stressed.
Velican
C
C
Velican
D
D
Tâncu
I
I
D000293:Adolescent; D000328:Adult; D003327:Coronary Disease / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology*; D006801:Humans; D008297:Male; D008867:Microtomy; D009336:Necrosis