Morphine inhibits the gastric acid secretion stimulated by 2-deoxy-D-glucose via a central mechanism in anesthetized rats.
The effect of morphine on the gastric acid secretion induced by 2-deoxy-D-glucose (2-DG) was investigated in the perfused stomach of anesthetized rats. The intravenous infusion of morphine (0.01-1.0 mg/kg per h for 2 h) dose dependently suppressed the gastric acid secretion stimulated by 2-DG. This inhibitory effect of morphine was completely reversed by naloxone (1.0 mg/kg i.v.) pretreatment. On the other hand, even the higher dose of morphine (1.0 mg/kg per h for 70 min) had no effect on the gastric acid secretion evoked peripherally by electrical stimulation of the vagus nerve. These observations indicate that morphine suppressed the 2-DG-induced gastric acid secretion via a central mechanism(s), probably mediated by the opiate receptor(s).
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Japan.
K
K
Watanabe
S
S
Yano
Y
Y
Minakawa
D000758:Anesthesia; D000818:Animals; D003837:Deoxy Sugars / Q000037:antagonists & inhibitors*; D003847:Deoxyglucose / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004558:Electric Stimulation; D005744:Gastric Acid / Q000378:metabolism*; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000502:physiology
D003837:Deoxy Sugars; D009270:Naloxone; D009020:Morphine; D003847:Deoxyglucose