[Prednisolone sensitivity of peripheral blood mononuclear cells of patients with systemic lupus erythematosus clinically resistant to glucocorticoids and the effects of carbon hemoperfusion].
A study was made of the sensitivity to prednisolone (PS) of peripheral blood mononuclear cells (MS) of patients with systemic lupus erythematosus (SLE) with renal lesion showing resistance to glucocorticoids (GC). It was shown that in most of the patients (60%) MC were poorly inhibited by PS whereas the rest of the patients (40%) demonstrated in vitro sensitivity compared to that of the donors and even higher in some cases. Thus, the group of SLE patients showing clinical resistance to GC action was inhomogeneous in sensitivity of their MC to PS; only some patients showed resistance associated with the properties of the MC system. Hemocarboperfusion was shown to produce a considerable effect on MC sensitivity to PS: higher sensitivity was noted in all the cases, it was particularly noticeable in the group of patients with low basal sensitivity to PS. An analysis of the data obtained led to a conclusion that hemocarboperfusion raised MC sensitivity to PS. This mechanism was shown to determine the efficacy of the method of therapy of resistance to GC.
G N
GN
Petrova
F S
FS
Baranova
L K
LK
Popova
A A
AA
Dmitriev
D000293:Adolescent; D000328:Adult; D001773:Blood Cells / Q000187:drug effects*; D002244:Carbon; D002478:Cells, Cultured; D004351:Drug Resistance; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000188:drug therapy*; D008297:Male; D011239:Prednisolone / Q000494:pharmacology*
D005938:Glucocorticoids; D002244:Carbon; D011239:Prednisolone
Chuvstvitel'nost' k prednizolonu mononuklearnykh kletok perifericheskoĭ krovi bol'nykh sistemnoĭ krasnoĭ volchankoĭ, klinicheski rezistentnykh k deiĭstviiu gliukokortikoidov, i vliianie gemokarboperfuzii.