Effects of an i.v. lethal dose of 3,4-methylenedioxyamphetamine (MDA) in the dog and antagonism by chlorpromazine.
A high intravenous (i.v.) dose of MDA (20 mg/kg) to mongrel dogs elevated body temperature, heart rate, mean arterial pressure and other cardiovascular parameters initially, but only the 1st two remained high. Other functions soon became quite depressed, and death shortly ensued. Arterial pO2 decreased, but pH and pCO2 showed a biphasic response after an initial decrease, Dogs that received chlorpromazine (10 mg/kg, i.v.) after MDA showed stabilization of physiological parameters, and survival through 48 hr.
Davis
W M
WM
Catravas
J D
JD
Waters
I W
IW
D015104:3,4-Methylenedioxyamphetamine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000662:Amphetamines / Q000633:toxicity*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006863:Hydrogen-Ion Concentration; D008297:Male; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D000662:Amphetamines; D015104:3,4-Methylenedioxyamphetamine; D002746:Chlorpromazine