Increase in blood serotonin levels in the hepatic venous outflow after intraportal tumour cell injection.
An important role of platelet-liberated serotonin (5-HT) for the hepatic lodgement of intraportally injected tumor cells was suggested in previous studies. In the present investigation the inferior caval vein was cannulated for determination of 5-HT levels in the hepatic venous outflow in association with tumour cell lodgement in the liver. A peak of 5-HT could be demonstrated in the inferior caval vein 15 min after intraportal tumour cell injection, indicating exposition of the liver to high local concentrations of 5-HT in excess of the metabolizing capacity of the liver, associated with tumour cell lodgement.
G
G
Blomqvist
G
G
Skolnik
A
A
Dahlström
H
H
Ahlman
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D006503:Hepatic Veins; D008102:Liver Circulation; D008297:Male; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000097:blood*; D051381:Rats; D012701:Serotonin / Q000097:blood*
D012701:Serotonin