Theoretical substantiation and recommendations of a system of biochemical criteria for the evaluation of the pre-pathological state due to the membrane-damaging effect of environmental factors.
Generalizations derived from experimental studies of enzymic disorganization and stability of membranes of cellular structures (microsomes, mitochondria, lysosomes, cytoplasmic membrane) of various organs and systems (liver, kidney, lung, brain, placenta, gonads, alveolar macrophages and others) due to hepato-, neuro-, gonado-, embryotoxic, mutagenic and carcinogenic effect of chemical pollutants of the environment are presented. Evaluation of the membrane-damaging effect taking into account the stage of labilization of biomembranes (according to severity of manifestation) and compensatory defence reactions at the moleculo-cellular level (alveolar macrophages) is recommended. Classification of biochemical methods (according to priority) is proposed for the evaluation of early functional changes during the examination of the health state of the population in dependence on the effect of environmental factors.
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Merkur'eva
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D003593:Cytoplasm / Q000201:enzymology; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects* / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology; D008861:Microsomes / Q000201:enzymology; D012306:Risk
D004785:Environmental Pollutants