[Sensitivity of zymosan-induced mononuclear liver infiltrates to hydrocortisone].
Experiments on mice showed that administration of hydrocortisone (125 mg/kg) 2 and 24 hours before and 2 and 24 hours after intravenous injection of zymosan granules in a dose of 2 mg per animal fails to prevent the formation of mononuclear infiltrates in the liver but delays their development.
Maianskiĭ
D N
DN
Rupakova
S A
SA
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004353:Drug Evaluation, Preclinical; D005260:Female; D006854:Hydrocortisone / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008107:Liver Diseases / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008808:Mice, Inbred CBA; D009000:Monocytes / Q000187:drug effects* / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D015054:Zymosan / Q000633:toxicity*
D015054:Zymosan; D006854:Hydrocortisone
Chuvstvitel'nost' zimozanindutsirovannykh mononuklearnykh infil'tratov pecheni k gidrokortizonu.