[Lymphopoietic function of mice with alloxan diabetes].
Alloxan diabetes (sucrose blood concentration greater than or equal to 14 mmol/l) induced lymphocytopenia in noninbred male mice, resulting from the decrease in the number of both T and B lymphocytes differentiated by their reaction to acid phosphatase. At the same time thymic bone marrow lymphopoiesis in mice with diabetes was depressed. Nodular and splenic lymphopoiesis remained virtually unchanged. These disturbances became apparent on the 3rd week after diabetes induction. Alloxan itself has no inhibitory effect on lymphopoiesis.
Kozlov
Iu A
IuA
Timofeeva
E E
EE
Zinger
M G
MG
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001854:Bone Marrow Cells; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D007958:Leukocyte Count; D008196:Lymph / Q000502:physiology*; D008231:Lymphopenia / Q000097:blood / Q000209:etiology; D008297:Male; D051379:Mice; D013950:Thymus Gland / Q000166:cytology; D013997:Time Factors
D001786:Blood Glucose
Sostoianie limfopoéza u mysheĭ s alloksanovym diabetom.