The structure of manumycin. II. Derivatives.
Derivatives of manumycin (1) were obtained by acetylation and reduction, respectively, and characterized by their spectroscopic data. Structure-activity relationships of the antibiotic were discussed.
Zeeck
A
A
Institut für Organische Chemie, Universität Göttingen, FRG.
Frobel
K
K
Heusel
C
C
Schröder
K
K
Thiericke
R
R
D000107:Acetylation; D000475:Alkenes / Q000032:analysis; D000900:Anti-Bacterial Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D006865:Hydrogenation; D008826:Microbial Sensitivity Tests; D011090:Polyenes; D053284:Polyunsaturated Alkamides; D013329:Structure-Activity Relationship
D000475:Alkenes; D000900:Anti-Bacterial Agents; D011090:Polyenes; D053284:Polyunsaturated Alkamides; C054474:manumycin