Phosphorothioate analogues of phosphoribosyldiphosphate are substrates of quinolinate phosphoribosyltransferase.
Phosphorothioate analogues of phosphoribosyldiphosphate (P-Rib-PP) can act as substrates of quinolinate phosphoribosyltransferase. The order of effectiveness as substrates, with Mg2+ as the activating metal ion, was P-Rib-PP greater than P-Rib-PPbeta S greater than P-Rib-PP alpha S(Sp) greater than P-Rib-PP alsph S(Rp). Cd2+ was more effective than Mg2+ with the Rp diastereommer.
Kunjara
S
S
Lee
C S
CS
Smithers
G W
GW
Shibata
K
K
Iwai
K
K
O'Sullivan
W J
WJ
D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D007668:Kidney / Q000201:enzymology; D007700:Kinetics; D008670:Metals / Q000494:pharmacology; D010428:Pentosephosphates / Q000378:metabolism*; D010430:Pentosyltransferases / Q000378:metabolism*; D012267:Ribosemonophosphates / Q000378:metabolism*; D013379:Substrate Specificity; D013552:Swine; D000098553:Nicotinate-Nucleotide Diphosphorylase (Carboxylating)
D008670:Metals; D010428:Pentosephosphates; D012267:Ribosemonophosphates; D010430:Pentosyltransferases; D000098553:Nicotinate-Nucleotide Diphosphorylase (Carboxylating)