[Effect of various supplies of vitamin B2 in the rat body on the activity of enzymes participating in the metabolism of xenobiotics].
Studies on the effect of different content of vitamin B2 (alimentary deficiency, additional administration) in the rat organism on the activity of enzymes participating in the metabolism of foreign substances and on the inducing effect of phenobarbital have shown that vitamin B2 to a considerable extent controls the activity of flavin-containing enzymes participating in the metabolism of xenobiotics (D-amino acid oxidase, xanthine and aldehyde oxidases, NADH- and NADPH-reductase activity of neotetrazolium) and a number of enzymes for which flavins do not play the role of prosthetic group (esterases aldehyde and formaldehyde dehydrogenases, demethylase and hydroxylase). Different content of vitamin B2 in animal organism also influences the action of phenobarbital, an inductor of xenobiotics metabolism, and the acetanilide biotransformation rate.
G Z
GZ
Lychik
A A
AA
Pentiuk
N B
NB
Lutsiuk
D000083:Acetanilides / Q000493:pharmacokinetics; D000818:Animals; D001711:Biotransformation; D004032:Diet; D004790:Enzyme Induction; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012256:Riboflavin / Q000008:administration & dosage; D012257:Riboflavin Deficiency / Q000201:enzymology* / Q000378:metabolism
D000083:Acetanilides; D006899:Mixed Function Oxygenases; D012256:Riboflavin
Vliianie razlichnoĭ obespechennosti organizma krys vitaminom B2 na aktivnost' fermentov, uchastvuiushchikh v metabolizme chuzherodnykh veshchestv.