Comparison of pharmacokinetic profiles of single and multiple doses of a slow release Oros oxprenolol delivery system in young normotensive and elderly hypertensive subjects.
Oxprenolol in an Oros 8/130 sustained release osmotic pump system (equivalent to 120 mg oxprenolol hydrochloride in a conventional formulation and releasing 8 mg h-1) was given to eight normal young subjects (mean age 23 years) and eight elderly hypertensive patients (mean age 77 years). The plasma concentration-time profiles of oxprenolol were determined over 32 h using gas liquid chromatography after the initial dose and following seven doses. The elderly patients had a significantly higher AUC and maximum plasma oxprenolol concentration following both the first and final doses studied. It is unlikely that this difference is due to a prolonged absorption phase in the elderly patients. Reduced drug clearance seems the most probable explanation.
Bradbrook
I D
ID
Babiker
M
M
Crome
P
P
Gillies
H C
HC
Morrison
P J
PJ
Rogers
H J
HJ
Shotton
P
P
D000328:Adult; D000367:Age Factors; D000368:Aged; D001798:Blood Proteins / Q000378:metabolism; D003692:Delayed-Action Preparations; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D010096:Oxprenolol / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism; D011485:Protein Binding
D001798:Blood Proteins; D003692:Delayed-Action Preparations; D010096:Oxprenolol