[Correlation between the anti-arrhythmia effect of ethacizin and pharmacokinetic parameters in a model of rhythm adoption by the heart].
Pharmacokinetics and pharmacodynamics of ethacizin were studied in a model of rhythm adoption by the heart, with the drug administered intravenously to anesthetized cats. A relation was demonstrated between blood ethacizin pattern and the drug's biphasic effect on the adoption of stimulation-imposed pace by the heart and ventricular fibrillation threshold. The estimated correlation coefficients, reflecting the relationship between the development of ethacizin anti-arrhythmic and antifibrillation effects and variation of its plasma levels between 10 and 120 min after the administration, were rather high (-0.85 and +0.93, respectively). Ethacizin shows anti-arrhythmic and antifibrillation activity when its plasma levels are between 2400 and 200 ng/ml.
Rodionov
A P
AP
Berdiaev
S Iu
SIu
Shestakova
N V
NV
Darinskiĭ
N V
NV
Kaverina
N V
NV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D001682:Biological Availability; D002415:Cats; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006207:Half-Life; D007700:Kinetics; D016293:Moricizine / Q000031:analogs & derivatives*; D010640:Phenothiazines / Q000378:metabolism / Q000627:therapeutic use*; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; C027240:diethylamino-ethmozine; D016293:Moricizine
Korreliatsiia mezhdu antiaritmicheskim deĭstviem etatsizina i farmakokineticheskimi parametrami na modeli usvoeniia ritma serdtsa.