Oestrogens and bone metabolism: a hypothesis.
The explanations so far proposed for the effects of oestrogens on bone metabolism in post-menopausal women have been based on the changes seen in calciotrophic hormones. However, we demonstrated in a previous study [6] that there is a decrease in the concentration of somatomedin (an insulin-like growth factor) and an increase in that of growth hormone (GH) in oestrogen-treated post-menopausal women. On the basis of those findings and the relevant data published in the literature, we advance a hypothesis to the effect that the bone-metabolism changes that occur in post-menopausal women following oestrogen replacement therapy come about via changes in serum somatomedin and growth hormone concentrations.
S A
SA
Duursma
J W
JW
Bijlsma
H C
HC
van Paassen
M C
MC
Slootweg
D000469:Alkaline Phosphatase / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood / Q000652:urine; D004997:Ethinyl Estradiol / Q000378:metabolism*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D008593:Menopause / Q000187:drug effects; D008875:Middle Aged; D010710:Phosphates / Q000097:blood; D013002:Somatomedins / Q000097:blood
D010710:Phosphates; D013002:Somatomedins; D004997:Ethinyl Estradiol; D013006:Growth Hormone; D000469:Alkaline Phosphatase; D006909:Hydroxyproline; D002118:Calcium