Intracellular generation of electronically excited states. Polymorphonuclear leukocytes challenged with a precursor of triplet acetone.
When the enol of isobutanal is added to polymorphonuclear cells, it undergoes an intracellular, myeloperoxidase-catalyzed aerobic oxidation with the formation of triplet acetone. The latter induces considerable damage if the enol concentration exceeds 2 mM. Cells which do not have myeloperoxidase are not damaged.
Nascimento
A L
AL
da Fonseca
L M
LM
Brunetti
I L
IL
Cilento
G
G
D000433:1-Propanol / Q000097:blood; D000096:Acetone / Q000031:analogs & derivatives*; D000447:Aldehydes / Q000097:blood; D000818:Animals; D003500:Cyclization; D005260:Female; D007700:Kinetics; D009504:Neutrophils / Q000502:physiology*; D010101:Oxygen Consumption; D020005:Propanols; D051381:Rats; D011919:Rats, Inbred Strains
D000447:Aldehydes; D020005:Propanols; C037881:triplet acetone; D000096:Acetone; D000433:1-Propanol; C017439:isobutyraldehyde