CCK-related peptides stimulation of the Na+/H+ antiport in pancreatic acinar cells leads to cytoplasmic alkalinisation.
Caerulein, gastrin and pentagastrin stimulation of the Na+/H+ exchange leads to intracellular alkalinisation in pancreatic acinar cells. Activation of protein kinase-C is the more probable mechanism involved in the effect of caerulein.
U151 INSERM, CHU Rangueil, Toulouse, France.
M J
MJ
Bastie
M
M
Dufresne
M
M
Delvaux
N
N
Vaysse
A
A
Ribet
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002108:Ceruletide / Q000494:pharmacology*; D003593:Cytoplasm / Q000378:metabolism*; D005755:Gastrins / Q000494:pharmacology*; D006168:Guinea Pigs; D006863:Hydrogen-Ion Concentration; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010418:Pentagastrin / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism
D005755:Gastrins; D002108:Ceruletide; D012964:Sodium; D010418:Pentagastrin