Opioid peptides. Structure-activity relationships in [OGly4] dermorphin tetrapeptides. X.
We describe the synthesis and preliminary in vitro and in vivo pharmacological tests of four [OGly4] tetrapeptide analogues of the opioid heptapeptide dermorphin H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2. The modification obtained by substituting aminoxy-acetic acid (OGly) for Gly4 provided analogues with substantial reduction of activity.
Salvadori
S
S
Minozzi
L
L
Tomatis
R
R
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004723:Endorphins / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D011930:Reaction Time / Q000187:drug effects; D013329:Structure-Activity Relationship
D004723:Endorphins; D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin