Synthesis and antibacterial properties of 7-[2-(3-substituted-5-isoxazolyl)-2-methoxyiminoacetamido]cep halospora nic acid derivatives.
The synthesis of new 2-(3-substituted-5-isoxazolyl)-2-methoxyiminoacetic acids and their condensation derivatives with a suitable cephalosporanic nucleus, is reported. Their antibacterial properties were tested in vivo and in vitro also against beta-lactamase producer microorganisms; particularly the oral bioavailability of some of these new derivatives was studied.
Sala
A
A
Zambon Group Research Laboratories, Bresso-Milano, Italy.
Chiarino
D
D
Napoletano
M
M
Albini
E
E
Carenzi
A
A
Della Bella
D
D
D000818:Animals; D000900:Anti-Bacterial Agents; D001424:Bacterial Infections / Q000188:drug therapy; D001682:Biological Availability; D002511:Cephalosporins / Q000032:analysis / Q000138:chemical synthesis* / Q000627:therapeutic use; D007536:Isomerism; D007555:Isoxazoles / Q000032:analysis / Q000138:chemical synthesis* / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000138:chemical synthesis*; D051381:Rats; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D007555:Isoxazoles; D010080:Oxazoles