Effects of protein intake variation and omega-3 polyunsaturated fatty acids on renal function in chronic renal disease.
Fifteen patients with chronic renal disease of various origin were investigated after 4 weeks protein restriction, after 4 weeks high protein intake and finally, after 8 weeks dietary supplementation with omega-3 polyunsaturated fatty acids (PUFA's), while adhering to a high protein intake. The highest values for effective renal plasma flow and glomerular filtration rate were observed after 8 weeks dietary supplementation with omega-3 PUFA's without a relationship with baseline values. Calculated renal resistance fell after omega-3 PUFA supplementation. Whether long term dietary supplementation with omega-3 PUFA's will influence the progression of chronic renal insufficiency in man needs further study.
Schaap
G H
GH
Department of Internal Medicine, Free University Hospital, Amsterdam, The Netherlands.
Bilo
H J
HJ
Popp-Snijders
C
C
Oe
P L
PL
Mulder
C
C
Donker
A J
AJ
D000328:Adult; D000368:Aged; D004041:Dietary Fats / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000187:drug effects; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged
D004041:Dietary Fats; D004044:Dietary Proteins; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D008074:Lipoproteins