[Iodo carboxamidino-1 phenyl-4 piperazine, a new adrenomedullary imaging agent: comparison with metaiodobenzylguanidine].
This report describes the comparison between two adrenal medulla imaging agents, mIBG and I-CPP. Biodistribution demonstrated an early and preferential uptake by both adrenal glands and heart and then storage in the adrenal gland of both agents, however I-CPP is less stable in vivo than mIBG. Reserpine depletion study in rat indicated that the I-CPP and mIBG uptake mechanisms are not similar.
Letiec
A
A
Guilloteau
D
D
Huguet
F
F
Baulieu
J L
JL
Besnard
J C
JC
Viel
C
C
D019797:3-Iodobenzylguanidine; D000313:Adrenal Medulla / Q000000981:diagnostic imaging*; D000818:Animals; D001693:Biological Transport, Active; D006146:Guanidines / Q000378:metabolism; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000378:metabolism; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D006146:Guanidines; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C035694:1-carboxamidino-4-phenylpiperazine; D019797:3-Iodobenzylguanidine
Iodo carboxamidino-1 phenyl-4 piperazine un nouvel agent potentiel pour l'imagerie de la medullosurrenale: comparaison avec la meta iodobenzylguanidine.