HLA associations in insulin-dependent diabetes mellitus diagnosed during pregnancy.
Sixty out of 63 patients with insulin-dependent diabetes mellitus (IDDM) diagnosed during pregnancy in the Diabetes Centre at the Department of Obstetrics and Gynaecology, Rigshospitalet, Copenhagen, were re-examined 2-16 years after diagnosis. Fourty-six patients were currently insulin-treated and the remaining 14 patients were all severely glucose intolerant. HLA-typing was carried out in 41 of these patients. The HLA phenotype distribution showed a highly significant difference from that of non-diabetics but was similar to that seen in IDDM not related to pregnancy. Thus, pregnancy may constitute a special trigger mechanism for IDDM, but the subsequent pathogenic mechanisms are probably the same as those involved in other cases of IDDM.
Hvidøre Hospital, Klampenborg, Denmark.
B
B
Møller-Jensen
K
K
Buschard
I
I
Buch
L
L
Mølsted-Pedersen
C
C
Kühl
B K
BK
Jakobsen
A
A
Svejgaard
D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006680:HLA Antigens / Q000235:genetics*; D006681:HLA-D Antigens / Q000235:genetics; D006801:Humans; D010641:Phenotype; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000235:genetics / Q000276:immunology*
D006680:HLA Antigens; D006681:HLA-D Antigens