Effect of chloroquine on biliary lipid and lysosomal enzyme output in the isolated perfused rat liver at low bile salt output rates.
Chloroquine, when introduced into isolated perfused rat livers, caused a substantial output of cholesterol into bile, occurring after 30 min and peaking at 60 min, whereas the biliary output of acid phosphatase and beta-glucuronidase increased only after 90 min. The origins of this bile-salt-independent cholesterol are discussed.
Department of Biochemistry, University of Birmingham, U.K.
K
K
Rahman
R
R
Coleman
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism*; D002738:Chloroquine / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D001647:Bile Acids and Salts; D002738:Chloroquine; D002784:Cholesterol; D000135:Acid Phosphatase; D005966:Glucuronidase