[Formation of thrombin and its inactivation by antithrombin III following repeated intravenous injections of tissue thromboplastin in animals].
A breach in the inactivation of thrombin activity by antithrombin III following numerous repeated intravenous injections of tissue thromboplastin to albino rats was established. Seven injections of tissue thromboplastin to animals (at 30-40 min-interval) caused functional exhaustion of anticoagulation system and increased thrombin blood circulation level.
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Pastorova
D000818:Animals; D000990:Antithrombin III / Q000032:analysis*; D001780:Blood Coagulation Tests; D005342:Fibrinolysis; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D013925:Thromboplastin / Q000008:administration & dosage / Q000494:pharmacology*
D000990:Antithrombin III; D013925:Thromboplastin; D013917:Thrombin
Obrazovanie trombina i ego neĭtralizatsiia antitrombinom III pri mnogokratnykh vnutrivennykh in''ektsiiakh zhivotnym tkanevogo tromboplastina.