Positive allergy prick tests associated with bronchial histamine responsiveness in an unselected population.
Bronchial responsiveness to histamine and skin prick test reactions to airborne allergens were measured in a random population sample of 891 adults and 1293 schoolchildren. Total serum IgE concentrations were measured in a subset of 389 adults. The prevalence of bronchial histamine responsiveness (BHR) in the adults increased from 5.8% in those who did not respond to allergen prick tests to 22.2% in those who responded to all five allergen groups (p less than 0.00001). Similarly, the prevalence of BHR in the children increased progressively from 3.5% to 35.3% as the number of positive allergen responses increased from zero through five (p less than 0.0001). In adults for whom IgE data were also available, those with BHR had a significantly higher total serum IgE concentration (p less than 0.002).
Witt
C
C
Stuckey
M S
MS
Woolcock
A J
AJ
Dawkins
R L
RL
D000328:Adult; D001249:Asthma / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects*; D001982:Bronchial Diseases / Q000150:complications / Q000503:physiopathology; D002648:Child; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D012882:Skin Tests
D007073:Immunoglobulin E; D006632:Histamine