Technetium-99m HM-PAO stereoisomers as potential agents for imaging regional cerebral blood flow: human volunteer studies.
A total of nine normal volunteer subjects were studied with three forms of [99mTc] hexamethylpropyleneamineoxime (HM-PAO), a potential cerebral blood flow imaging agent. One, the d,l isomer, showed 4.1% uptake in the brain which remained constant over 8 hr. There was good differentiation between uptake in gray and white matter on tomographic slices. We propose that this agent may allow regional cerebral blood flow imaging to be performed on a routine basis.
Sharp
P F
PF
Smith
F W
FW
Gemmell
H G
HG
Lyall
D
D
Evans
N T
NT
Gvozdanovic
D
D
Davidson
J
J
Tyrrell
D A
DA
Pickett
R D
RD
Neirinckx
R D
RD
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D010091:Oximes / Q000378:metabolism; D011877:Radionuclide Imaging; D013237:Stereoisomerism; D013667:Technetium / Q000378:metabolism; D019690:Technetium Tc 99m Exametazime; D014018:Tissue Distribution
D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D013667:Technetium