Mutagenicity of 1,2-dibromo-3-chloropropane (DBCP) in the mouse spot test.
The spot test with 1,2-dibromo-3-chloropropane (DBCP) was carried out using male PW and female C57BL/6 mice. DBCP induced recessive colour spots in offspring with a significantly high frequency of 2.9%, showing that this chemical is mutagenic for somatic cells of mice in vivo.
Sasaki
Y F
YF
Imanishi
H
H
Watanabe
M
M
Sekiguchi
A
A
Moriya
M
M
Shirasu
Y
Y
Tutikawa
K
K
D000818:Animals; D003433:Crosses, Genetic; D005038:Ethylnitrosourea / Q000633:toxicity; D005260:Female; D005808:Genes, Recessive / Q000187:drug effects*; D006200:Hair Color / Q000187:drug effects; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009152:Mutagenicity Tests / Q000379:methods; D009154:Mutation; D011247:Pregnancy; D011407:Propane / Q000031:analogs & derivatives* / Q000633:toxicity
D007306:Insecticides; C007318:1,2-dibromo-3-chloropropane; D005038:Ethylnitrosourea; D011407:Propane