Toxic effects of ozone on murine L929 fibroblasts. Damage to DNA.
Damage to DNA caused by exposure of L929 fibroblasts to ozone was reflected by the generation of strand breaks, DNA inter-strand cross-links and DNA-protein cross-links. Addition of propan-2-ol, a hydroxyl radical scavenger, did not affect the formation of strand breaks. In model experiments it appeared that both purines and pyrimidines were involved in DNA inter-strand and DNA-protein cross-links.
Department of Medical Biochemistry, Sylvius Laboratories, Leiden, The Netherlands.
J
J
Van der Zee
E
E
Van Beek
T M
TM
Dubbelman
J
J
Van Steveninck
D000818:Animals; D002460:Cell Line; D004247:DNA / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage; D005347:Fibroblasts / Q000378:metabolism*; D051379:Mice; D009705:Nucleosides / Q000378:metabolism; D010126:Ozone / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013050:Spectrometry, Fluorescence
D009705:Nucleosides; D012710:Serum Albumin, Bovine; D010126:Ozone; D004247:DNA