The penems, a new class of beta-lactam antibiotics. 7. Synthesis and antimicrobial activity of 2-heterocyclylmercaptoalkyl derivatives.
2-Heterocyclylmercaptoalkyl penems were synthesized and their in vitro potency was established. The compounds exhibit moderate to strong antibacterial activity against various Gram-positive and Gram-negative bacteria. Their antimicrobial activity is related to the nature of the heterocycle, the length of the hydrocarbon spacer between the 2-position of the penem nucleus and the mercapto group, and the substitution pattern of the C-6 position of the penem skeleton.
Lang
M
M
Schneider
P
P
Tosch
W
W
Scartazzini
R
R
Zak
O
O
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D013329:Structure-Activity Relationship; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams