Genotoxicity studies of benz[l]aceanthrylene.
The genotoxicity of the cyclopenta-fused polycyclic aromatic hydrocarbon, benz[l]aceanthrylene (B[l]A), was evaluated in vitro using the L5178Y/TK+/- mouse lymphoma assay and in vivo using the mouse peripheral blood lymphocyte (PBL) culture system. The mutagenicity and sister chromatid exchange (SCE) inducing potential of B[l]A was then compared to that of benzo[a]pyrene (B[a]P). B[l]A appeared to be slightly less mutagenic than B[a]P at the TK locus, and each compound produced both small and large colony mutants indicating that they are clastogenic as well as mutagenic. Gross chromosome aberration analysis of treated L5178Y/TK+/- mouse lymphoma cells confirmed the clastogenicity of B[l]A in vitro. In the mouse PBL system, after administration by gavage, B[l]A was more cytotoxic and produced a sharper elevation in SCE frequency than B[a]P.
Kligerman
A D
AD
Moore
M M
MM
Erexson
G L
GL
Brock
K H
KH
Doerr
C L
CL
Allen
J W
JW
Nesnow
S
S
D000818:Animals; D001551:Benz(a)Anthracenes / Q000633:toxicity*; D001564:Benzo(a)pyrene / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002869:Chromosome Aberrations / Q000187:drug effects*; D007940:Leukemia L5178 / Q000235:genetics / Q000473:pathology; D008214:Lymphocytes / Q000166:cytology / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008938:Mitosis / Q000187:drug effects; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013937:Thymidine Kinase / Q000235:genetics
D001551:Benz(a)Anthracenes; D009153:Mutagens; D001564:Benzo(a)pyrene; C041193:benz(l)aceanthrylene; D013937:Thymidine Kinase