The metabolism of t-butylcyclohexane in Fischer-344 male rats with hyaline droplet nephropathy.
The molecule t-butylcyclohexane is one of the first examples of a branched alkyl group attached to a hydrocarbon ring shown to be capable of producing renal damage at the corticomedullary junction of male rats. A metabolic study of t-butylcyclohexane yielded the following urinary metabolites: trans-4-t-butylcyclohexanol, 2c-hydroxy-4t-t-butylcyclohexanol, 2-methyl-2-cyclohexylpropanoic acid, 2c-hydroxy-4c-t-butylcyclohexanol, 2-methyl-2-cyclohexyl-1,3-propanediol, 2t-hydroxy-4t-t-butylcyclohexanol, and cis -4-t-butylcyclohexanol. As with other hydrocarbons of similar molecular weight that induce nephropathy in male rats, preferential sites of oxidative metabolism were observed that could potentially be related to the pathogenesis.
Harry G. Armstrong Aerospace Medical Research Laboratory, Wright-Patterson AFB, OH.
G M
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Henningsen
K O
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Yu
R A
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Salomon
M J
MJ
Ferry
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Lopez
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Roberts
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Servè
D000818:Animals; D003510:Cyclohexanes / Q000378:metabolism*; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D008968:Molecular Conformation; D051381:Rats; D011916:Rats, Inbred F344; D013329:Structure-Activity Relationship
D003510:Cyclohexanes; C054362:tert-butylcyclohexane