The rat MIS1/Pvt-1 locus is syntenic with MYC on chromosome 7.
Mouse Pvt-1 and rat MIS1 are frequent proviral integration sites in retrovirally induced lymphomas. The Pvt-1 locus is also involved in mouse plasmacytoma (6;15) and in the variant Burkitt lymphoma (2;8) translocations. We show that the Pvt-1/MIS1 locus is syntenic with MYC on rat chromosome 7. This is consistent with a postulate of close linkage and, possibly, a functional relationship between the MYC protooncogene and the MIS1/Pvt-1 locus.
Department of Tumor Biology, Karolinska Institutet, Stockholm, Sweden.
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S
Ingvarsson
Z
Z
Wirschubsky
J
J
Szpirer
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G
Levan
G
G
Klein
J
J
Sümegi
D000818:Animals; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D006822:Hybrid Cells / Q000166:cytology; D008099:Liver / Q000166:cytology; D051379:Mice; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D011519:Proto-Oncogenes; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D014178:Translocation, Genetic
D004247:DNA