Respiratory function following nalbuphine and morphine in anaesthetized man.
In 40 patients anaesthetized with thiopentone, 66% nitrous oxide and 1% halothane, the effects of a single i.v. dose of nalbuphine 4.5, 8, 15, 25 or 50 mg/70 kg or morphine 3, 5, 10 or 17.5 mg/70 kg on total ventilation and end-tidal carbon dioxide concentration have been measured. Depression of respiration occurred with both drugs and with all doses. The lower doses of nalbuphine produced more depression than equianalgesic doses of morphine. Conventional equianalgesic doses produced similar degrees of depression. With the highest dose of morphine, respiratory impairment progressed to apnoea whereas, with nalbuphine, apnoea did not occur in any patient. With increasing dosage of nalbuphine there appeared to be a limit to the extent of respiratory depression. The highest dose of nalbuphine produced less depression than some lower doses, suggesting a reversal effect.
Klepper
I D
ID
Rosen
M
M
Vickers
M D
MD
Mapleson
W W
WW
D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D001682:Biological Availability; D003864:Depression, Chemical; D006801:Humans; D008875:Middle Aged; D009019:Morphinans / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D009266:Nalbuphine / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
D009019:Morphinans; D009020:Morphine; D009266:Nalbuphine