Comparison of electrochemical detection methods in liquid chromatography for the determination of N-acetylcysteine in plasma.
Three electrochemical detection systems for the liquid chromatography of N-acetylcysteine in plasma have been compared: a dropping-mercury electrode detector, an amalgamated-gold electrode detector and a system in which iodine is generated electrochemically in the column effluent. The last detector approaches the reproducibility of the first (R.S.D. = 2%) and is as sensitive as the second, with a detection limit of 0.1 micrograms/ml plasma.
W T
WT
Kok
J J
JJ
Halvax
R W
RW
Frei
D000111:Acetylcysteine / Q000097:blood*; D002853:Chromatography, Liquid; D004229:Dithiothreitol / Q000032:analysis; D004563:Electrochemistry; D007202:Indicators and Reagents
D007202:Indicators and Reagents; D004229:Dithiothreitol; D000111:Acetylcysteine