Circulating immune complexes in cancer patients.
Circulating Immune Complexes (CIC) have been described in malignant diseases. To elucidate their potential clinical significance, CIC of seventy-eight patients with cancer and of seventy-one normal individuals were studied. Total protein and immunoglobulin composition of CIC were quantitatively measured. Patients sera had consistently higher titers of CIC than normal individuals. Sodium Dodecyl Sulfate/Polyacrylamide Gel Electrophoresis (SDS/PAGE) showed subtle differences in the CIC protein composition between patients and normal individuals.
Department of Surgery, Mount Sinai School of Medicine, New York, N.Y.
S
S
Jaramillo
M
M
Shafir
G
G
Bekesi
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis*; D005260:Female; D005833:Genital Neoplasms, Female / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis / Q000145:classification; D007414:Intestinal Neoplasms / Q000276:immunology; D008297:Male; D008545:Melanoma / Q000276:immunology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*
D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D009363:Neoplasm Proteins