The basic concept: clearance.
Gibaldi
M
M
D000818:Animals; D001682:Biological Availability; D004334:Drug Administration Schedule; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*
D004364:Pharmaceutical Preparations