Neurotoxicity assessment of O-ethyl-O'-(2-diisopropylaminoethyl) methylphosphonite (QL) in hens.
O-ethyl-O'-(2-diisopropylaminoethyl) methylphosphonite (QL), an intermediate in the formation of ethyl S-2-diisopropylaminoethyl methylphosphonothiolate, was evaluated for neurotoxicity in the adult hen. Birds were given a single oral dose of QL ranging from 635 to 6080 mg kg-1. The QL-treated hens were observed for up to 24 h after dosing for acute toxicologic effects and over a 24 d post-dose period for evaluation of delayed neurotoxicity. The oral LD50 in hens is 1186 mg kg-1. Neurologic dysfunction, as evidenced by motor incapacitation, was observed at 6 days and thereafter after treatment with QL. Neurotoxic esterase (NTE) activity was not inhibited at 24 h after exposure to compound. Neural damage, multifocal in nature, was noted in the peripheral nervous system of QL-treated hens at dose levels greater than or equal to 635 mg kg-1, oral dose. These findings indicate neural damage tendencies following QL exposure.
E J
EJ
Olajos
J
J
Bergmann
J T
JT
Weimer
H
H
Wall
D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors; D002645:Chickens; D005260:Female; D007928:Lethal Dose 50; D009412:Nerve Fibers / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D009946:Organothiophosphorus Compounds / Q000633:toxicity; D010275:Parasympathetic Nervous System / Q000187:drug effects; D014317:Tritolyl Phosphates / Q000633:toxicity
D002265:Carboxylic Ester Hydrolases; D009943:Organophosphorus Compounds; D009946:Organothiophosphorus Compounds; D014317:Tritolyl Phosphates; C048366:O-ethyl-O'-(2-diisopropylaminoethyl)methylphosphonite; C009680:VX-agent; C021859:neurotoxic esterase; C025541:tri-o-cresyl phosphate