REV 5901 and Ly 171,883 protect rat gastric mucosa against ethanol-induced damage.
The effect of the leukotriene antagonist, Ly 171,883, or the 5-lipoxygenase inhibitor, REV 5901, on ethanol-induced gastric lesion formation in the rat was investigated. Pretreatment with REV 5901 resulted in a dose dependent decrease in lesion length. Doses of 32 and 64 mg/kg induced nearly complete protection against ethanol, while doses of 1 and 8 mg/kg were much less effective. With Ly 171,883, 32 and 64 mg/kg doses less dramatically reduced lesion length. These findings implicate products of the 5-lipoxygenase pathway in the production of ethanol-induced gastric lesions.
Division of Experimental Therapeutics, Wyeth Laboratories, Inc., Philadelphia, PA 19101.
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Nielsen
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Beninati
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Chang
D000098:Acetophenones / Q000494:pharmacology*; D000818:Animals; D001393:Azoles / Q000494:pharmacology*; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects*; D006912:Hydroxyquinolines / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors; D008297:Male; D011804:Quinolines; D051381:Rats; D011919:Rats, Inbred Strains; D013189:SRS-A / Q000037:antagonists & inhibitors; D013777:Tetrazoles / Q000494:pharmacology*
D000098:Acetophenones; D001393:Azoles; D006912:Hydroxyquinolines; D016859:Lipoxygenase Inhibitors; D011804:Quinolines; D013189:SRS-A; D013777:Tetrazoles; C049740:alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol; D000431:Ethanol; C044660:LY 171883