Antitumor activity on line 10 hepatoma in strain 2 guinea pigs and pharmaceutical properties of quinonyl-MDP preparations.
The pharmaceutical properties of quinonyl-MDP-66 were discussed with special reference to the stability of oil-in-water emulsion, distribution capacity into regional lymph nodes and tumor regressive activity. The oil-in-water emulsion of quinonyl-MDP-66, which was prepared by treatment of quinonyl-MDP-66 with squalane (25 x) and emulsified with aqueous solution of 5% HCO-60 and 5.6% d-mannitol, was kept in lyophylized state and used after reconstitution by the addition of water before use. The reconstituted suspension of quinonyl-MDP-66 in oil-in-water emulsion was stable for more than 24 hrs. The oil-in-water emulsion of quinonyl-MDP-66 as prepared above was effective for the distribution of quinonyl-MDP-66 into regional lymph node in rats and for the regression of line 10 hepatoma in strain 2 guinea pigs by intralesional injection.
I
I
Azuma
Y
Y
Ogawa
Y
Y
Igari
S
S
Ukei
Y
Y
Yamamura
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D000277:Adjuvants, Pharmaceutic / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology*; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D004655:Emulsions; D005260:Female; D006168:Guinea Pigs; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology*; D008198:Lymph Nodes / Q000378:metabolism; D008297:Male; D009368:Neoplasm Transplantation; D013997:Time Factors
D000277:Adjuvants, Pharmaceutic; D000970:Antineoplastic Agents; D004655:Emulsions; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C023846:quinonyl-MDP-66