Mutagenicity of quercetin in Chinese hamster lung cells in culture.
Quercetin, a flavonol that is widely distributed in edible plants, was assayed for cytotoxic and mutagenic activities on Chinese hamster lung cells in culture, using diphtheria toxin resistance as a selective marker. Results showed that it was cytotoxic, and induced a dose-dependent increase in the number of diphtheria-toxin-resistant mutants in the absence of a metabolic activation system.
M
M
Nakayasu
H
H
Sakamoto
M
M
Terada
M
M
Nagao
T
T
Sugimura
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006224:Cricetinae; D004167:Diphtheria Toxin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D005419:Flavonoids / Q000633:toxicity*; D066298:In Vitro Techniques; D009152:Mutagenicity Tests; D009153:Mutagens; D011794:Quercetin / Q000633:toxicity*
D004167:Diphtheria Toxin; D005419:Flavonoids; D009153:Mutagens; D011794:Quercetin