Kinetic models of induction: II. Decreased turnover of a product or its precursor.
Reduction of the turnover rate constant for a substance or its metabolic precursor is a mechanism for induction which differs markedly in its kinetic characteristics from induction resulting from a direct stimulation of synthesis. The unique aspect of induction following inhibited turnover is that the time course of recovery from the induced to the basal state is more rapid than the time course for induction itself. A general set of kinetic equations is presented here which represents the complete chain of events for such an induction; namely the kinetics of the inducer, the kinetics of a synthesis precursor to the induced product, and the kinetics of the induced product itself. These equations have been used to simulate examples of this type of induction and resemble induction experiments from the literature.
Abramson
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FP
D004790:Enzyme Induction / Q000187:drug effects*; D006207:Half-Life; D007700:Kinetics; D008954:Models, Biological