Disorders of the serum electrolytes, acid-base balance, and renal function in alcoholism.
This chapter reviews the disturbances of the serum sodium and potassium concentrations, acid-base imbalances, and acute renal dysfunction that are seen frequently in alcoholic patients. The hyponatremia common in decompensated cirrhotics is caused by an impairment of renal free water clearance and concomitant water ingestion. Excessive proximal renal tubular sodium reabsorption and nonosmotic vasopressin release underlie the defect in renal water excretion in cirrhosis. Restriction of water intake is the principal therapeutic measure for hyponatremia. Hypokalemia is common in alcoholics but when observed does not always represent true potassium depletion. Although most cirrhotics have a diminished total body potassium content, intracellular potassium concentration is usually normal. In some patients gastrointestinal and renal potassium losses and nutritional potassium deficiency may cause true potassium depletion. Respiratory and metabolic alkalosis are the acid-base disturbances seen most frequently in alcoholics. Acidosis is relatively uncommon and is usually due to renal insufficiency, lactic acid or keto-acid accumulation. Toxin ingestion (methanol, ethylene glycol, or isopropanol) may also cause severe acidosis. Rhabdomyolysis, common in severe alcoholism, may produce various electrolyte disturbances and acute renal failure. The prognosis for recovery is good although temporary dialysis may be necessary.
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D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000503:physiopathology; D000141:Acidosis, Renal Tubular / Q000503:physiopathology; D058186:Acute Kidney Injury / Q000503:physiopathology; D000437:Alcoholism / Q000503:physiopathology*; D000471:Alkalosis / Q000503:physiopathology; D001127:Arginine Vasopressin / Q000097:blood; D004573:Electrolytes / Q000097:blood*; D005919:Glomerular Filtration Rate; D006801:Humans; D007008:Hypokalemia / Q000503:physiopathology; D007010:Hyponatremia / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology*; D007684:Kidney Tubules / Q000503:physiopathology; D007773:Lactates / Q000097:blood; D008104:Liver Cirrhosis, Alcoholic / Q000503:physiopathology; D009212:Myoglobinuria / Q000503:physiopathology
D004573:Electrolytes; D007773:Lactates; D001127:Arginine Vasopressin