Glucose metabolism in the obese hyperglycaemic (C57B1/6 ob/ob) mouse: the effects of fasting on glucose turnover rates.
Rates of glucose turnover and of glucose-carbon recycling in fed and fasted C57B1/6 ob/ob mice were measured using D-[6(-3)H/U-14C]-glucose. In both the fed and fasted state, obese mice had significantly higher blood glucose concentrations than their lean littermates. This hyperglycaemia was a consequence of elevated rates of glucose synthesis and of glucose-lactate (Cori cycle) recycling.
S A
SA
Smith
M A
MA
Cawthorne
D L
DL
Simson
D000818:Animals; D004435:Eating; D005215:Fasting; D006943:Hyperglycemia / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000378:metabolism*