[Features of the action of opioid peptides and naloxone on the tissues of the central and peripheral nervous system during cultivation].
The effect of opioid peptides (leu-enkephalin, a synthetic analog of leu-enkephalin) and naloxone on the organotypic culture of rat spinal cord and dorsal root ganglia was studied. The explants' outgrowth and dorsal root ganglion neuron survival were studied. Peptides (10(-9) M-10(-10)M) and naloxone (10(-5) M-10(-6) M) were found to be able to stimulate fibre outgrowth from the explant, to increase the numbers of glia and fibroblast type cells in the ganglion growth zone. It is suggested that opioid peptides can be used as a source of nonspecific growth factor for nervous tissue of peripheral and central nerve system.
O B
OB
Il'inskiĭ
M V
MV
Kozlova
E S
ES
Kondrikova
V U
VU
Kalenchuk
M I
MI
Titov
D000818:Animals; D046508:Culture Techniques; D004347:Drug Interactions; D004622:Embryo, Mammalian; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D005727:Ganglia, Spinal / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology*; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects*
D009270:Naloxone; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Osobennosti deĭstviia opioidnykh peptidov i naloksona na tkan' tsentral'noĭ i perifericheskoĭ nervnoĭ sistemy v usloviiakh kul'tivirovaniia.