Interaction of cis-Pt(ino)2Cl2 with amino acids.
The reactions of cis-Pt(ino)2Cl2 with the amino acids Gly, L-Ala, L-Val, L-Ileu, L-Phe and L-Pro were studied in methanolic solutions. The (1:1) adducts of the formulas cis-[Pt(ino)2(am-ac)]Cl were isolated from these reactions in the solid state, which in turn produce the cis-[Pt(ino)2(am-acH)Cl]Cl complexes, by treating the former with equivalent amounts of HCl, in aqueous solutions. The complexes were characterized with elemental analysis, conductivity measurements, IR, 1H NMR, and 13C NMR spectra. The results show that the purine ring of inosine interacts with the aliphatic side chain of the amino acids. The platination increases the percentage of the C3'-endo-anti conformation of the sugar part of inosine.
Department of Chemistry, University of Ioannina, Greece.
A
A
Garoufis
R
R
Haran
M
M
Pasdeloup
J P
JP
Laussac
N
N
Hadjiliadis
D000596:Amino Acids; D055598:Chemical Phenomena; D002621:Chemistry; D002945:Cisplatin; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000596:Amino Acids; D002945:Cisplatin