Carcinogenicity of small doses of inhaled N-nitrosoacetoxymethyl-N-methylamine in Syrian golden hamsters.
Male Syrian golden hamsters inhaled 0.5-1 ppm (= 2.7-5.5 mg/m3) of N-nitroso-N-acetoxy-methyl-N-methylamine 1 h/week, for 14 weeks. The total dose per animal was calculated as 150-400 micrograms or 1-3 mg/kg. Four squamous cell carcinomas and one mucoepidermoid carcinoma of the nasal mucosa were observed. No such tumors occurred in the control group.
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RG
Klein
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P
Schmezer
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D
Komitowski
D000818:Animals; D002277:Carcinoma / Q000139:chemically induced / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000473:pathology; D006224:Cricetinae; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D008297:Male; D008647:Mesocricetus; D009669:Nose Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors
C014659:methyl(acetoxymethyl)nitrosamine; D004128:Dimethylnitrosamine