Prevention and reversal of ouabain-induced cardiotoxicity by naloxone in the guinea-pig.
The effects of pre- and post-treatment with naloxone on the cardiotoxicity of ouabain in the guinea-pig were studied. After pretreatment with naloxone, the dose of ouabain required to induce ventricular arrhythmias and cardiac arrest were significantly increased, in a dose-dependent manner, compared with the control, indicating a protective effect of naloxone against digitalis intoxication. Administration of naloxone at the onset of cardiac arrhythmias induced by a lethal dose of ouabain restored the cardiac rhythm and consequently saved life in seven out of eight animals, indicating an antiarrhythmic effect of naloxone in digitalis-intoxicated guinea-pigs. The protective and antiarrhythmic effects of naloxone against digitalis intoxication have clinical implications.
A Y
AY
Lee
T W
TW
Unang
T M
TM
Wong
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D004072:Digitonin / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006323:Heart Arrest / Q000139:chemically induced; D009270:Naloxone / Q000494:pharmacology*; D010042:Ouabain / Q000633:toxicity*
D009270:Naloxone; D010042:Ouabain; D004072:Digitonin