Sex steroid receptors in transformed human cervical tissue.
Investigation of the binding affinity, the concentration and the DNA binding ability of the sex steroid receptors in transformed human cervical tissue has shown considerable changes in comparison to normal specimens. Lower level of hormone receptors and higher dissociation constants are the essential characteristics of the majority of analysed transformed tissue specimens. The DNA binding of steroid-receptor complexes is in agreement with mentionated data. These preliminary results are just one more evidence on the existence of relationship between modified properties of sex steroid receptors and different histological alterations of their target tissues. Further investigations are necessary to make some conclusion about the possible involvement of estrogen and progesterone receptors in pathological transformation of the portio vaginalis uteri.
V
V
Sulovic
J
J
Milasin
N
N
Ribarac-Stepic
M
M
Brocic
D
D
Kanazir
D000230:Adenocarcinoma / Q000378:metabolism; D000328:Adult; D002482:Cellulose / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D010212:Papilloma / Q000378:metabolism; D011127:Polyps / Q000378:metabolism; D011397:Promegestone / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D002577:Uterine Cervical Diseases / Q000378:metabolism*; D002578:Uterine Cervical Dysplasia / Q000378:metabolism; D002579:Uterine Cervical Erosion / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D004958:Estradiol; D002482:Cellulose; D004247:DNA; D011397:Promegestone