Adjunctive therapy of phenytoin overdose--a case report using plasmaphoresis.
Phenytoin is widely used as an anticonvulsant. In overdose situations phenytoin demonstrates saturable metabolic kinetics making treatment difficult. Phenytoin's high protein binding makes it a poor candidate for hemodialysis or hemoperfusion. We report a case of an attempted suicide in which plasmaphoresis was used in an attempt to lower plasma levels and reduce toxicity. A review of the use of plasmaphoresis in acute intoxications is included.
L S
LS
Larsen
J R
JR
Sterrett
B
B
Whitehead
S M
SM
Marcus
D000328:Adult; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008862:Microsomes, Liver / Q000378:metabolism; D009145:Mushroom Poisoning / Q000628:therapy; D010269:Paraquat / Q000506:poisoning; D010278:Parathion / Q000506:poisoning; D010672:Phenytoin / Q000378:metabolism / Q000506:poisoning*; D010956:Plasmapheresis; D011803:Quinine / Q000506:poisoning; D013406:Suicide, Attempted
D010672:Phenytoin; D010278:Parathion; D011803:Quinine; D010269:Paraquat