The effect of normovolaemic haemodilution on the early patency rate of small calibre vascular prostheses studied in a new animal model.
A new animal model has been developed to study early thrombosis in small calibre vascular prostheses. It consists of an ePTFE graft 2 cm long and of 3mm internal diameter inserted into a rabbit abdominal aorta in which the distal run-off is reduced by narrowing both common iliac arteries using clips with a standard gap. Scanning electron microscopy and in vivo gamma imaging of the graft using labelled autologous platelets showed that, as in the human, platelets played a primary role in the model graft thrombosis. This model was used to study the effect of haemodilution on early graft patency. Moderate normovolaemic haemodilution dramatically improved the early patency rate.
Mahir
M S
MS
Hynd
J W
JW
Flute
P T
PT
Dormandy
J A
JA
D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001792:Blood Platelets / Q000502:physiology; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D001809:Blood Viscosity; D004195:Disease Models, Animal; D006083:Graft Occlusion, Vascular / Q000517:prevention & control; D006438:Hemodilution; D008297:Male; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D013927:Thrombosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control