[Effect of blastolysin on the development of specific immunity to whooping cough].
The influence of blastolysin, the cell-wall glycopeptide of Lactobacillus bulgaricus, on the main immunobiological properties of pertussis vaccine, its immunogenicity and toxicity, has been studied. The use of blastolysin, introduced as a stimulating agent in definite doses and following definite administration schedules, has been shown to permit achieving not only an increase in the immunogenicity of the corpuscular pertussis vaccine, but also a considerable decrease in its toxicity and histamine-sensitizing activity.
Shepeleva
I B
IB
Zakharova
N S
NS
Remova
T N
TN
Bazhanova
I G
IG
Britsina
M V
MV
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D006020:Glycopeptides / Q000627:therapeutic use; D006632:Histamine / Q000276:immunology; D007109:Immunity / Q000187:drug effects; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000276:immunology / Q000633:toxicity; D014917:Whooping Cough / Q000276:immunology* / Q000517:prevention & control
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D010567:Pertussis Vaccine; C025182:blastolysin; D006632:Histamine
Vliianie blastolizina na razvitie spetsificheskogo immuniteta k kokliushu.