Large keratoacanthomas in difficult locations treated with intralesional 5-fluorouracil.
Keratoacanthoma is a benign tumor; however, it may cause massive destruction of normal tissue during its rapid growth phase. Intralesional 5-fluorouracil (5-FU) has been shown to be an effective treatment for keratoacanthoma. We have successfully treated five patients with large keratoacanthomas in difficult locations. There have been no recurrences during follow-up periods ranging from 18 to 45 months. Intralesional 5-FU may be ineffective for keratoacanthomas that are not rapidly proliferating.
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D000328:Adult; D000368:Aged; D005148:Facial Dermatoses / Q000188:drug therapy*; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D007636:Keratoacanthoma / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D005472:Fluorouracil