Nifedipine-induced hyporeactivity in delayed hypersensitivity skin tests.
Four patients and three healthy volunteers were submitted to delayed hypersensitivity skin tests to candidin, tuberculin, streptokinase/streptodornase (SK/SD) and mumps antigen before and after a 1 week treatment with nifedipine 10 mg q. 8h. A decrease in the scores of induration and erythema was observed, especially in response to SK/SD antigen challenge. We conclude that nifedipine may induce an anergy status in delayed hypersensitivity skin tests.
Department of Internal Medicine, C.H.U. André Vésale, Université Libre de Bruxelles, Montigny-le-Tilleul, Belgium.
F
F
Derenne
M
M
Vanhaeverbeek
D
D
Brohée
D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007165:Immunosuppression Therapy; D007428:Intradermal Tests; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D012882:Skin Tests
D009543:Nifedipine