[Transplacental effect of methylcobalamine on the growth of embryonic mouse kidney tissue in organotypic cultivation].
Transplacental growth-stimulating effect of the Cbl-coenzyme methylcobalamine (MeCbl) was revealed in organ cultures of embryonic kidney tissue in DBA/2 mice. MeCbl improved the survival of embryonic kidney explants and decreased the incidence of degenerative damage in cultures. The frequency of regeneration development was 30%. Hyperplastic epithelial changes were much more marked after transplacental MeCbl administration (71.8%), than in the control (9.0%).
Golenko
O D
OD
Ryzhova
N I
NI
D000818:Animals; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced / Q000473:pathology; D007668:Kidney / Q000187:drug effects* / Q000196:embryology / Q000473:pathology; D051379:Mice; D008811:Mice, Inbred DBA; D009924:Organ Culture Techniques; D010920:Placenta / Q000187:drug effects*; D011247:Pregnancy; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000494:pharmacology
C019476:mecobalamin; D014805:Vitamin B 12
Transplatsentarnyĭ éffekt metilkobalamina na rost émbrional'noĭ tkani pochek mysheĭ pri organotipicheskom kul'tivirovanii.