[Glomerular filtration and tubular reabsorption of glucose in insulin-dependent diabetes in children].
Although glycosuria is important in the control of diabetes in children, few studies clearly show its significance as compared to glycemia. The aim of the present study was therefore to determine the two parameters that control glucose presence in urine, i.e. glucose glomerular filtration rate (GFR) and tubular reabsorption (JrG). GFR was measured by using a 110 min polyfructosan perfusion in 96 diabetic children and adolescents. The results are as follows: 1) In this population there is a significant correlation (p less than 0.01) between the quantity of glucose in urine and mean glycemia during the test; 2) polyfructosan clearance that reflects GFR in diabetic children without renal complication is 2.11 +/- 0.04 ml/s 1.73 m2, or 126 +/- 2.4 ml/min 1.73 m2 (mean +/- SEM); it is higher than in the reference values already published; 3) JrG is correlated with glucose filtered load (p less than 0.01), GFR (p less than 0.01) and sodium reabsorption (p less than 0.01). The ratio JrG/GFR could be substituted for the classical concept of "renal threshold", as it can be easily measured and may help in interpreting glycosuria in some diabetic children. To conclude, in IDD children, the parameters controlling glycosuria may be studied by a simple method. The clinical value of such renal exploration has still to be determined.
Darmaun
D
D
Robert
J J
JJ
Chevrot
M
M
Dieterlen
P
P
Reach
G
G
Desjeux
J F
JF
D000042:Absorption; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism / Q000503:physiopathology*; D005630:Fructans; D005919:Glomerular Filtration Rate; D005947:Glucose / Q000378:metabolism*; D006029:Glycosuria / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007684:Kidney Tubules / Q000378:metabolism*
D001786:Blood Glucose; D005630:Fructans; C002938:polyfructosan; D005947:Glucose
Filtration glomérulaire et réabsorption tubulaire du glucose dans le diabète insulinodépendant de l'enfant.