Use of a novel non-steroidal anti-inflammatory drug in the horse.
In a two-part cross-over experiment in six ponies, an acute inflammatory reaction was generated by injecting carrageenin solution into subcutaneously-implanted tissue-cages lined with fibrovascular granulation tissue. In each part of the cross-over, half of the ponies received a novel phenylpyrazoline anti-inflammatory agent (BW540C) orally and half received a placebo treatment. BW540C inhibited platelet cyclo-oxygenase for 24 h but the reductions in exudate eicosanoid concentrations were less pronounced. A significant suppression in the rise of surface skin temperature in BW540C-treated ponies paralleled drug-induced inhibition of thromboxane B2 bicyclic prostaglandin (PG) E2 concentrations at the inflamed site. The drug had no significant effect on 6-keto-PGF1 alpha, migrating leucocytes, lactate dehydrogenase or total protein in exudates. Maximum plasma concentrations of both compounds occurred 2 to 4 h after dosing and maximum exudate levels of drug and metabolite occurred at 12 h. Both compounds penetrated approximately three times less readily into exudate than into plasma.
Higgins
A J
AJ
Royal Veterinary College, North Mymms, Hatfield, Hertfordshire.
Lees
P
P
Sedgwick
A D
AD
Buick
A R
AR
Churchus
R
R
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D005122:Exudates and Transudates / Q000032:analysis / Q000187:drug effects; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses / Q000378:metabolism*; D007249:Inflammation / Q000188:drug therapy / Q000662:veterinary*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D011720:Pyrazoles / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D013929:Thromboxane B2 / Q000032:analysis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D013929:Thromboxane B2; C046216:BW 540C; D007770:L-Lactate Dehydrogenase