Cerebral 2-deoxyglucose uptake in rats during ethanol withdrawal and postwithdrawal.
The overt ethanol withdrawal syndrome is associated with a generalized increase in cerebral uptake of 2-deoxyglucose. Relatively high elevations of 2-deoxyglucose were observed in many structures associated with motor function, the mamillary body-anterior thalamus-cingulate cortex pathway, many thalamic nuclei, and the raphe. Overtly withdrawing rats had higher levels of 2-deoxyglucose than postwithdrawing animals that had been abstinent for 1-5 weeks in 96% of the gray areas evaluated. Postwithdrawal was associated with increased amounts of 2-deoxyglucose in comparison to controls in 80% of the gray areas evaluated. Postwithdrawal and control rats did not differ in some areas involved with motor function and some limbic structures, such as the mamillary body-anterior thalamus-cingulate cortex pathway. It is concluded that the ethanol-withdrawal syndrome results in alterations in cerebral physiology, some of which persist for at least 5 weeks postwithdrawal.
M J
MJ
Eckardt
G A
GA
Campbell
C A
CA
Marietta
E
E
Majchrowicz
H N
HN
Wixon
F F
FF
Weight
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism; D000431:Ethanol / Q000009:adverse effects*; D005947:Glucose / Q000378:metabolism*; D008032:Limbic System / Q000378:metabolism; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D013997:Time Factors
D012701:Serotonin; D000431:Ethanol; D003847:Deoxyglucose; D005947:Glucose