Fibrinopeptide A increases after chorionic villus sampling.
Fibrinopeptide levels were measured in 20 women during transcervical chorionic villus sampling (CVS). Fibrinopeptide A, a sensitive indicator of fibrinogen cleavage by thrombin, significantly increased in five subjects, whereas there was no change in B beta peptide, an indicator of fibrinolysis. The data suggest that modest fibrin formation, uncompensated by fibrinolysis, may be induced in some women by CVS.
Al-Gailani
F
F
Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611.
Elias
S
S
Simpson
J L
JL
Green
D
D
D000328:Adult; D001706:Biopsy; D002824:Chorionic Villi / Q000473:pathology*; D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen / Q000378:metabolism*; D005344:Fibrinopeptide A / Q000378:metabolism*; D005345:Fibrinopeptide B / Q000378:metabolism; D006801:Humans; D008431:Maternal-Fetal Exchange; D010446:Peptide Fragments / Q000378:metabolism; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012307:Risk Factors
D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; C033786:fibrinogen Bbeta (15-42); D005344:Fibrinopeptide A; D005345:Fibrinopeptide B; D005340:Fibrinogen