Daily changes of protein synthesis and secretion rates in rat liver slices.
The rates of protein synthesis and secretion in rat liver slices showed temporal variability, as assessed by the use of [14C]leucine. The protein synthesis showed daily changes with two maxima at 13:00 and 01:00 hr and minimum at 17:00 hr. The secretion rate also varies within 24 hr showing biphasic pattern. The pattern of daily secretion rate for hydrophobic proteins differed from the pattern observed for acid proteins and glycoproteins.
Lityńska
A
A
Wójczyk
B
B
D000818:Animals; D002250:Carbon Radioisotopes; D002940:Circadian Rhythm; D066298:In Vitro Techniques; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D011506:Proteins; D007930:Leucine