Higher ATP level and reduced glucose consumption of red cells stored in PVC bags compared to glass bottles.
Whole blood stored for 21 days at +4 degrees C in glass bottles showed a decrease in plasma glucose content of 6.6 mM/l, while blood stored in polyvinylchloride bags had a decrease of only 5.3 mM/l. At the same time, red cell ATP was reduced to 69% in bottles compared to 80% in bags (statistically proved differences). The higher red cell ATP level may explain the increased stability of red cells stored in DEHP-plasticized blood bags. The reduction in glucose consumption suggested that the decrease of red cell ATP and plasma glucose content may be a result of some unidentified inhibitory effects of DEHP on biochemical processes.
National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
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D000255:Adenosine Triphosphate / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001793:Blood Preservation / Q000295:instrumentation*; D004051:Diethylhexyl Phthalate; D004912:Erythrocytes / Q000378:metabolism*; D005898:Glass; D006801:Humans; D066298:In Vitro Techniques; D011143:Polyvinyl Chloride
D001786:Blood Glucose; D000255:Adenosine Triphosphate; D011143:Polyvinyl Chloride; D004051:Diethylhexyl Phthalate