[In vitro hormone tests in human breast cancers and their relevance for therapy of metastasizing breast cancer].
In vitro tests applied to cell cultures of metastasised mammary carcinomas revealed high hormonal independence versus testosterone and/or oestradiol, prednisone, progesterone, and prolactin, and in some cases tumour growth was even stimulated by those hormones. Hormonal therapy on the basis of the in vitro parameters was applied to 62 patients with metastatic mammary carcinoma. In vitro findings were closely correlated to in vivo results.
Klinik für Chirurgie im Bereich Medizin, Karl-Marx-Universität Leipzig.
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Schönfelder
D001943:Breast Neoplasms / Q000032:analysis / Q000188:drug therapy*; D003114:Colony-Forming Units Assay; D004958:Estradiol / Q000032:analysis; D005260:Female; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D009362:Neoplasm Metastasis; D009376:Neoplasms, Hormone-Dependent / Q000032:analysis / Q000188:drug therapy*; D011374:Progesterone / Q000032:analysis; D011388:Prolactin / Q000032:analysis; D013739:Testosterone / Q000032:analysis; D014410:Tumor Stem Cell Assay
D006728:Hormones; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin
In-vitro-Hormontests menschlicher Mammakarzinome und ihre Relevanz für die Therapie des metastasierenden Mammakarzinoms.