Motor endplate involvement in the extraocular muscles of the myotonic rat.
The motor endplates from the extraocular muscles of rats administered 20,25-diazacholesterol were examined by electron microscopy. Many anomalies were found at various levels of the junctional complex. Electron microscopy showed disrupted sole-plate nuclei, disruptions of the junctional sarcoplasm, atypical sarcoplasmic extensions, simplified postsynaptic areas, and interposition of Schwann cell cytoplasm between axonal terminal and muscle fiber with a reduplication of basement membrane, as well as atrophic and disrupted axonal terminals. These data indicate that the motor endplate is affected as well as the muscle fiber in myotonic dystrophy.
Pachter
B R
BR
Eberstein
A
A
D000818:Animals; D005123:Eye / Q000473:pathology*; D008297:Male; D009045:Motor Endplate / Q000648:ultrastructure*; D009132:Muscles / Q000473:pathology; D009223:Myotonic Dystrophy / Q000473:pathology*; D009469:Neuromuscular Junction / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains