[Age characteristics of the development of a reserpine model of parkinsonism in rats].
The studies were performed on 9-month- and 26-month-old rats. Electrodes were implanted into the nucleus caudatus, globus pallidus and substantia nigra. It has been found that with ageing the greatest decrease in the background electrical activity was found in n. caudatus and the least in globus pallidus. Old rats showed the signs of relative extrapyramidal insufficiency, i. e. hypokinesia and enhanced tremor. Due to 7-day reserpine administration the adult animals developed a marked hypokinesia, while the old rats showed an enhanced tremor. The author has found qualitative age-dependent differences in the changes of the electrical activity of the structures in question, as well as the interdependence between the initial electrical activity of n. caudatus of old rats and their death following reserpine administration.
Rushkevich
Iu E
IuE
D000375:Aging / Q000502:physiology*; D000818:Animals; D002421:Caudate Nucleus / Q000503:physiopathology; D004409:Dyskinesia, Drug-Induced; D005917:Globus Pallidus / Q000503:physiopathology; D008297:Male; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D012110:Reserpine; D013378:Substantia Nigra / Q000503:physiopathology; D014202:Tremor / Q000139:chemically induced
D012110:Reserpine
Vozrastnye osobennosti razvitiia rezerpinovoĭ modeli parkinsonizma u krys.