Inhibitory action of furosemide on the active chloride transport of papillary heart muscle in rabbit.
The action of furosemide on the intracellular chloride activity, ai(Cl), of rabbit papillary muscle was investigated with Cl ion selective microelectrodes. With furosemide concentrations greater than 1 microM, ai(Cl) decreased. Furthermore, the decrease in ai(Cl) was larger as the furosemide concentration increased. Lowering the extracellular sodium concentration, [Na]o, by replacing Na with choline, significantly reduced the effect of furosemide on ai(Cl). The results provide evidence that the membrane of rabbit heart cells possess a furosemide sensitive chloride transport mechanism related to [Na]o.
Oyama
Y
Y
Walker
J L
JL
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D005665:Furosemide / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010210:Papillary Muscles / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors
D002712:Chlorides; D005665:Furosemide