Influence of an essential fatty acid deficient diet on absorption of topical hydrocortisone in the rat.
Using a rat dermatosis model, produced by dietary essential fatty acid deficiency (EFAD), which is characterized by histological changes and elevated transepidermal water loss, changes in skin permeability were studied using [14C]-hydrocortisone (HC). Skin, serum and urinary levels of HC were measured, and absorption and excretion of HC in EFAD rats compared with that in control rats on a normal diet. This animal model has demonstrated the importance of the functional integrity of the horny layer in skin penetration.
Lambrey
B
B
Centre International de Recherches Dermatologiques, Sophia Antipolis, Valbonne, France.
Schalla
W
W
Kail
N
N
Lahmy
J P
JP
Schaefer
H
H
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D004041:Dietary Fats / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005228:Fatty Acids, Essential / Q000008:administration & dosage*; D005260:Female; D006854:Hydrocortisone; D010539:Permeability; D051381:Rats; D012869:Skin Absorption; D012871:Skin Diseases / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D004041:Dietary Fats; D005228:Fatty Acids, Essential; D006854:Hydrocortisone