Taeniasis unresponsive to a single dose of niclosamide: case report of persistent infection with Taenia saginata and a review of therapy.
A patient infected in Ethiopia with the beef tapeworm Taenia saginata was unsuccessfully treated with 2 g of niclosamide on four separate occasions over four months. clinical and parasitologic cures were effected by a regimen of 2 g of niclosamide given on three consecutive days. Niclosamide is the drug of choice for treatment of T. saginata and Taenia solium (pork tapeworm) infection; cure rates are approximately 90%. It is not absorbable and thus is nontoxic. Alternative treatments of taeniasis vary in the degree of safety; tin compounds and Aspidium extracts often are toxic. Paromomycin sulfate, which is also nonabsorbable, is effective, although adverse gastrointestinal effects are common with multiple-dose regimens. A relatively safe therapy is with mebendazole, a broad-spectrum anthelmintic agent, although efficacy has varied in different trials. A number of benzimidazoles, as well as nitazoxamide, have been effective against tapeworms. Praziquantel is the best alternative to niclosamide in terms of cost, efficacy, availability, and safety.
D000328:Adult; D004334:Drug Administration Schedule; D005002:Ethiopia; D006801:Humans; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use; D009534:Niclosamide / Q000008:administration & dosage* / Q000627:therapeutic use; D010303:Paromomycin / Q000627:therapeutic use; D011223:Praziquantel / Q000627:therapeutic use; D013622:Taeniasis / Q000188:drug therapy*
D010303:Paromomycin; D011223:Praziquantel; D008463:Mebendazole; D009534:Niclosamide