Lack of first-pass metabolism of ethanol at blood concentrations in the social drinking range.
Previously published data are displayed in a new manner and show that there is complete systemic availability of oral doses of 23-47 g of ethanol (0.35-0.75 g/kg or 30-60 ml of 95% ethanol) in man when administered in the fasting state relative to an intravenous infusion of the same doses administered over a 2-hr period. A previous report by other authors that oral ethanol (0.15 g/kg) in man had a mean systemic availability of only 29% is explained by the fact that the subjects were fed one hour prior to administration of the alcohol and that the intravenous dose was infused over only a 20 minute period.
D000042:Absorption; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood*; D005215:Fasting; D005502:Food; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008297:Male
D000431:Ethanol