title: The effect of triflumuron (SIR8514) on the free-living stages of sheep nematodes.
abstract: Studies both in vitro and in vivo showed that the insect growth regulator, triflumuron, exhibited potent larvacidal effects against the free-living stages of Trichostrongylus colubriformis. Effects were not as marked on the closely related nematodes, Haemonchus contortus and Ostertagia circumcincta. Nevertheless, these findings suggest that growth regulators may be used to develop novel methods of nematode control, and thus offer alternatives or adjuncts to conventional anthelmintic therapy and at the same time reduce the selection for anthelmintic resistance.
mesh_terms: D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D005243:Feces / Q000469:parasitology; D006188:Haemonchiasis / Q000188:drug therapy / Q000662:veterinary; D006189:Haemonchus / Q000187:drug effects*; D010028:Ostertagia / Q000187:drug effects*; D010029:Ostertagiasis / Q000188:drug therapy / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy / Q000469:parasitology; D014251:Trichostrongyloidea / Q000187:drug effects*; D014253:Trichostrongylosis / Q000188:drug therapy / Q000662:veterinary; D014254:Trichostrongylus / Q000187:drug effects*
chemical_list: D001549:Benzamides; C023957:triflumuron