title: Studies on cytotoxic constituents in pericarps of Mallotus japonicus, Part II.
abstract: Two new phloroglucinol derivatives, mallotolerin (8) and mallotochromanol (9), were isolated from the cytotoxic fraction of the pericarps of Mallotus japonicus. The new derivatives were identified as 3-(3-methyl-2-hydroxybut-3-enyl)-5-(3-acetyl-2,4-dihydroxy-5-me thy l-6- methoxybenxyl)-phlorbutyrophenone (8) and 8-acetyl-5,7-dihydroxy-6-(3-acetyl-2,4-dihydroxy-5-methyl-6- methoxybenxyl)2,2-dimethyl-3-hydroxychroman (9) by their respective chemical and spectral data. These compounds were found to be cytotoxic against KB and L-5178Y cell lines in culture and to be moderately effective in inhibiting the growth of Ehrlich carcinoma in mice. Cytotoxic activities of the isolated phloroglucinol derivatives (1-9) from the pericarps are also discussed.
mesh_terms: D000107:Acetylation; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis* / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D002852:Chromatography, Ion Exchange; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010946:Plants, Medicinal / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000972:Antineoplastic Agents, Phytogenic