Enhanced production of dolichol, but not dolichyl phosphate, in the earliest stages of rat liver regeneration.
The regenerating liver presents a changed ability to use mevalonate 16 hr after partial hepatectomy. The dolichol content and its synthesis from mevalonate is increased, while no variation of dolichyl-P and ubiquinone parameters are detectable. The greater amount of mevalonate utilized to form dolichol, but not dolichyl-P, in this proliferating system, raises some questions about the physiological significance of these isoprenoid compounds and about their biosynthetic sequence.
D000818:Animals; D004224:Diterpenes / Q000096:biosynthesis*; D004288:Dolichol Phosphates / Q000096:biosynthesis*; D004286:Dolichols / Q000096:biosynthesis*; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D008798:Mevalonic Acid / Q000378:metabolism; D011106:Polyisoprenyl Phosphates / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004224:Diterpenes; D004288:Dolichol Phosphates; D004286:Dolichols; D011106:Polyisoprenyl Phosphates; C028306:dolichol monophosphate; D008798:Mevalonic Acid