Iodine-131 treatment of thyroid cancer: absorbed dose calculated from post-therapy scans.
The radiation absorbed dose for nine neck lesions distributed among four thyroid-cancer patients was measured directly from images taken after administration of a treatment dose of 131I. The tumor volume was measured with anterior plus lateral pinhole images by determining magnification and assuming an ellipsoidal shape. Uptake and effective half-life were determined from serial anterior images by use of a calibration curve. Dose lower limits ranged from 2,400 to 29,900 rad. Response to treatment was judged on the basis of one or more follow-up scans at least 8 mo later. All lesions responded to the therapy administration which ranged from 150 to 175 mCi.
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary; D000328:Adult; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary; D005260:Female; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011877:Radionuclide Imaging; D011879:Radiotherapy Dosage; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy*
D007457:Iodine Radioisotopes