Oleylglycerol hydrolysis and acyl-CoA-independent transacylation with cholesterol by enzyme preparations from pig aorta.
We demonstrated preferential hydrolysis of trioleylglycerol greater than 1.3-dioleylglycerol greater than 1-monooleylglycerol expressed as acyl equivalents of glycerol rather than fatty acid released by pig aortic lipase. Transacylation with cholesterol occurred in the reverse order of the substrates in an appropriate reaction system. The pathobiochemical importance of the results with respect to metabolism and differential accumulation of acylglycerols and acylcholesterols in the arterial wall is discussed.
D000214:Acyl Coenzyme A / Q000378:metabolism; D000217:Acyltransferases / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000201:enzymology*; D002784:Cholesterol / Q000378:metabolism*; D005233:Fatty Alcohols / Q000378:metabolism; D005989:Glycerides / Q000378:metabolism*; D006868:Hydrolysis; D008049:Lipase / Q000378:metabolism; D013552:Swine
D000214:Acyl Coenzyme A; D005233:Fatty Alcohols; D005989:Glycerides; D002784:Cholesterol; D000217:Acyltransferases; D008049:Lipase