Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio.
The enantiomers of hexobarbital, designated as S(+)-HB and R(-)-HB, were administered intra-arterially to rats in a dose of 25 mg X kg-1. Blood pharmacokinetics of the parent compound and two metabolites as well as urinary excretion of three major metabolites were studied. Using previously obtained data following oral administration of S(+)-HB and R(-)-HB two different methods for calculation of the hepatic extraction ratio (E) were compared. The metabolite profile in the urine after intra-arterial administration was not basically different from corresponding data on oral administration. The clearance of low-dose, intra-arterially administered S(+)-HB is useful as an indicator of hepatic blood flow in the rat.
D000818:Animals; D002849:Chromatography, Gas; D006591:Hexobarbital / Q000008:administration & dosage / Q000378:metabolism*; D007269:Injections, Intra-Arterial; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
D006591:Hexobarbital