Kidney growth and collagen content in rat pups from uninephrectomized mothers.
The effect of uninephrectomy (UNX) or sham-operation (SO) in pregnant rats at the 5th-7th day of gestation upon pup kidney development was studied. In newborns, kidney wet weight was low in pups of the SO and UNX groups, kidney/body weight was low in UNX only; collagen was highest in UNX. At 6 weeks, wet weight was least in UNX; dry weight was low and %H2O high in SO and UNX; collagen/dry weight was high in SO and UNX. Maternal surgery (SO or UNX) appears to impose a non specific development deficit upon pups, although kidney collagen growth is sustained; no specific renotropic activity was evident in pups of the UNX groups.
D000818:Animals; D000831:Animals, Newborn; D001834:Body Water / Q000378:metabolism; D001835:Body Weight; D003094:Collagen / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D009392:Nephrectomy; D009929:Organ Size; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains
D003094:Collagen