Role of Na+ and K+ on the increased 5-HT secretion from platelets of spontaneously hypertensive rats.
We have compared the effect of Na+ and K+ on the serotonin secretion induced by thrombin in platelets from spontaneously hypertensive rats (SHR) and age-matched control animals (WKY). Decrease in external Na+ concentration did not modify the secretory response of either species of platelets; furthermore addition of veratridine and amiloride had no effect. Elevation of external K+ concentration stimulated the thrombin-induced 5-HT secretion, even in the absence of external Ca2+, in both species of platelet, and addition of monensin induced a selective release of serotonin without modifying the response to subsequent addition of thrombin. Platelet secretion therefore appears not to be identical to neuronal secretion and the observed difference between SHR and WKY platelets does not seem to depend upon alteration in Na+ and K+ cellular metabolism.
D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D006973:Hypertension / Q000503:physiopathology; D008985:Monensin / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D011921:Rats, Inbred WKY / Q000502:physiology; D012701:Serotonin / Q000378:metabolism*; D012964:Sodium / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013917:Thrombin / Q000494:pharmacology; D014701:Veratridine / Q000494:pharmacology
D012701:Serotonin; D014701:Veratridine; D000584:Amiloride; D008985:Monensin; D012964:Sodium; D013917:Thrombin; D011188:Potassium