Influence of aluminum on mineralization during matrix-induced bone development.
A model of de novo mineralization employing matrix-induced endochondral bone formation in rats was used to study the short-term effects of aluminum on the deposition of calcium and phosphate in vivo. In experiments where systemic aluminum concentrations were elevated, the cellular processes associated with bone development appeared to be normal, if somewhat delayed, however precipitation of the mineral phase was prevented. This suggests a primary direct physical chemical effect of aluminum in vivo on calcification, as suggested by in vitro studies which demonstrate that aluminum is a potent inhibitor of calcium phosphate precipitation. Aluminum salts implanted locally with the matrix appeared to be toxic to the cellular processes leading to chondrogenesis and osteogenesis.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D001857:Bone Matrix / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism; D002113:Calcification, Physiologic / Q000187:drug effects*; D002130:Calcium Phosphates / Q000378:metabolism*; D008297:Male; D008903:Minerals / Q000378:metabolism; D051381:Rats
D002130:Calcium Phosphates; D008903:Minerals; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; D000535:Aluminum; D000469:Alkaline Phosphatase; C485829:calcium phosphate, dibasic, anhydrous