[Availability of propylphenazone from suppositories. 2. Bioavailability].
The examination of the bioavailability from 4 different preparations of propyphenazone suppositories on a fatty base, studied in 10 healthy volunteers, showed bioequivalence as was judged by means of the AUC-values. Aminophenazone suppositories of an equivalent dosage led to significant higher values of plasma concentrations if compared with propyphenazone. The in vivo findings correlate with in vitro results of availability.
D000328:Adult; D000983:Antipyrine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D001682:Biological Availability; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D013488:Suppositories
D013488:Suppositories; C009077:propyphenazone; D000983:Antipyrine
Verfügbarkeit von Propyphenazon aus Suppositorien. 2. Mitteilung: Bioverfügbarkeit.