title: Hyper-induction of skin ornithine decarboxylase activity in psoriatic patients.
abstract: Ornithine decarboxylase activity was measured in skin from 14 normal and 24 psoriatic subjects (with stable plaque type psoriasis vulgaris) using punch biopsies carried out immediately (0 h) and 6 h after stimulation by cellotape stripping. At 0 h, no significant difference was found between normal and involved or uninvolved psoriatic skin, but a significant increase was measured 6 h after tape stripping. This increase was significantly greater in uninvolved and involved psoriatic skin compared with normal skin. Preliminary results indicated that these changes were localized in the epidermis.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D004790:Enzyme Induction; D004817:Epidermis / Q000201:enzymology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D011565:Psoriasis / Q000201:enzymology*; D012867:Skin / Q000201:enzymology*; D013997:Time Factors
chemical_list: D009955:Ornithine Decarboxylase