No evidence for serotonergic-adrenergic interactions in the canine total cardiovascular system.
Possible in vivo interactions of serotonin and noradrenaline were investigated in 7 anesthetized mongrel dogs. The hemodynamic effects of three different doses of serotonin (10, 50 and 100 micrograms/kg/min) were analyzed with and without noradrenaline treatment (0.05-0.1 micrograms/kg/min). There were no significant differences in peripheral and cardiac responses between the pure serotonin effect and the hemodynamic effects of a parallel serotonin-noradrenaline infusion. The discussed amplifying effect of serotonin on the adrenergic system could not be observed in the total canine cardiovascular system.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000502:physiology; D011985:Receptors, Serotonin / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects
D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; D012701:Serotonin; D009638:Norepinephrine