Inhibition of muscular triglyceride lipolysis by ketone bodies: a mechanism for energy-preservation in starvation.
Using the forearm technique, muscle substrate balances were measured in healthy volunteers under the influence of a low dose intraarterial infusion of beta-hydroxybutyrate. The ketone body led to a prompt cessation of muscular release of glycerol and free fatty acids, indicating inhibited muscular triglyceride lipolysis. This finding confirms the concept of substrate regulation of muscle triglyceride lipolysis in vivo.
D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006885:Hydroxybutyrates / Q000494:pharmacology*; D007657:Ketone Bodies / Q000494:pharmacology*; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D009132:Muscles / Q000378:metabolism*; D013217:Starvation / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism*
D000090:Acetoacetates; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007657:Ketone Bodies; D014280:Triglycerides; C016635:acetoacetic acid; D005990:Glycerol; D020155:3-Hydroxybutyric Acid