title: Pharmacokinetic of sodium cefoperazone in calves.
abstract: Na-CPZ was administered to ten calves i.v. and i.m. at the dosages of 15 and 30 mg/Kg b.w. in order to study its pharmacokinetic parameters. Plasma protein binding was evaluated in vitro by the ultracentrifugation technique. Short half-lives were obtained after i.v. (53.61 min) and i.m. (47.71 min) administration at the dosage of 15 mg/kg b.w., similar values were obtained after i.v. (55.19 min) and i.m. (64.21 min) administration of 30 mg/kg b.w. The mean value of bioavailability (F) following the injection of both dosages was about 45%. Plasma protein binding at therapeutical concentrations was evaluated about 44%. The Authors conclude that a daily i.m. administration of 30 mg/Kg b.w. of Na-CPZ produces serum therapeutical levels for about 8 hours against the most sensitive microorganisms and 5 hours against the less sensitive ones.
mesh_terms: D000818:Animals; D001682:Biological Availability; D001798:Blood Proteins / Q000378:metabolism; D002417:Cattle / Q000378:metabolism*; D002438:Cefoperazone / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D011485:Protein Binding
chemical_list: D001798:Blood Proteins; D002438:Cefoperazone