[Effect of the herbicide Herbazin-50 (simazine) on the wound process in animals].
Herbazin 50 was used as an experimental model to record species differences in the process of wound healing in horses, cattle, and sheep. It was established that the local and oral application of this herbicide inhibited wound healing, and this effect was more strongly manifested in the phase of hydratation. There were clearly expressed species-associated variations: in horses the elimination of the irritant was achieved through a severe inflammation response of a purulent character, while in cattle the rapid response of the connective tissue was leading, with concurrent premature maturation. Changes set in under the effect of the herbicide, consisting in the alkalinization of the wound exudate, which led to changes in the wound microflora.
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D002417:Cattle; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D006540:Herbicides / Q000627:therapeutic use*; D006736:Horses; D012756:Sheep; D012839:Simazine / Q000627:therapeutic use*; D013045:Species Specificity; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary
D006540:Herbicides; D012839:Simazine
Vliianie na kherbitsida kherbazin-50 (simazin) vŭrkhu raneviia protses pri zhivotnite.