title: Fluidity of cadaveric blood after sudden death: Part III. Acid-base balance and fibrinolysis.
abstract: In rats, fibrinolytic activity and acidosis increased rapidly after death. Postmortem fibrinolysis and the pH, base excess (BE), and [HCO3-] levels were affected by the method of sacrifice: the lower the pH, BE, and [HCO3-] levels, the higher the fibrinolytic activity. Conversely, in experiments using the vascular perfusion technique, low pH, BE, and [HCO3-] levels of the perfusate induced abundant release of plasminogen activator from the vascular wall.
mesh_terms: D000136:Acid-Base Equilibrium; D000818:Animals; D001769:Blood / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism*; D003645:Death, Sudden / Q000209:etiology; D005338:Fibrin Fibrinogen Degradation Products / Q000097:blood; D005342:Fibrinolysis; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D011180:Postmortem Changes; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005338:Fibrin Fibrinogen Degradation Products