title: Neuropeptide investigations with an ovine surgical model.
abstract: An ovine surgical model for peptide investigations is presented. Techniques for exteriorization of the carotid artery, catheterization of the sagittal sinus, hypophysectomy via a transnasopharyngeal approach, and ventricular and cisternal cannulation in the sheep are employed within the model. Several experimental applications in neurosurgical research are presented.
mesh_terms: D000758:Anesthesia; D000818:Animals; D002339:Carotid Arteries / Q000601:surgery; D002404:Catheterization / Q000379:methods; D002408:Catheters, Indwelling; D002552:Cerebral Ventricles / Q000098:blood supply; D002946:Cisterna Magna / Q000098:blood supply; D003399:Craniotomy / Q000379:methods; D004388:Dura Mater / Q000098:blood supply; D005260:Female; D007016:Hypophysectomy / Q000379:methods; D008297:Male; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000097:blood* / Q000134:cerebrospinal fluid; D009493:Neurosurgery / Q000379:methods*; D010477:Perfusion; D012756:Sheep; D012772:Shock, Septic / Q000097:blood / Q000134:cerebrospinal fluid
chemical_list: D009419:Nerve Tissue Proteins