[Electrophysiological and morphological analysis of the cardiotoxic action of ethanol in rats].
The experiments on male rats showed that oral ethanol administered in a dose of 8 g/kg (2/3 of LD50) daily for a month produces toxic heart damage whose electrophysiological and morphological characteristics are similar to clinico-anatomical manifestations of human alcohol myocardiodystrophy. It was concluded that the model may be used for the search of new pharmacological agents for the treatment and prevention of alcohol myocardiodystrophy.
D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D002310:Cardiomyopathy, Alcoholic / Q000503:physiopathology; D004562:Electrocardiography; D000431:Ethanol / Q000633:toxicity*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051381:Rats; D013997:Time Factors
D000431:Ethanol
Elektrofiziologicheskiĭ i morfologicheskiĭ analiz kardiotoksicheskogo deĭstviia étanola u krys.