[Comparative effectiveness of the beta-(N,N-diethylamino)ethylamide hydrochloride of fusaric acid, obzidan and atenolol in experimental adrenaline-induced cardiac arrhythmia].
Hydrochloride beta-(N,N-diethylamino)ethylamide of fusaric acid (DAEA) exerted an antiarrhythmic activity in adrenaline-induced arrhythmia in rats. DAEA single pretreatment in doses of 1-5 mg/kg prevented the disorders of rhythm and conductivity in most animals. A pronounced antiarrhythmic effect was manifest at doses of 2 and 4 mg/kg of DAEA. The comparison of efficacy of DAEA, obzidan and atenolol showed that atenolol exhibited only a low antiarrhythmic activity, DAEA prevented the development of arrhythmia in 50% of animals in a dose of 1.7 mg/kg (1/42 of LD50) and obzidan--1 mg/kg (1/40 of LD50), respectively. The antiarrhythmic effect of DAEA was not followed by marked suppression of cardiac conductivity.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D001262:Atenolol / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D004837:Epinephrine; D005669:Fusaric Acid / Q000031:analogs & derivatives / Q000627:therapeutic use*; D008297:Male; D010848:Picolinic Acids / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*; D051381:Rats
D000889:Anti-Arrhythmia Agents; D010848:Picolinic Acids; D001262:Atenolol; C034341:fusaric acid N,N-diethylaminoethylamide; D011433:Propranolol; D005669:Fusaric Acid; D004837:Epinephrine
Sravnitel'naia éffektivnost' gidrokhlorida beta-(N,N-diétilamino)étilamida fuzarinovoĭ kisloty, obzidana i atenolola pri éksperimental'noĭ adrenalinovoĭ aritmii serdtsa.