The effect of a novel thromboxane synthetase inhibitor dazmegrel (UK38485) on random pattern skin flaps in the rat.
In the light of work (Emerson and Sykes, 1981) suggesting a protective effect of prostacyclin on the random pattern dorsal skin flap of the rat, the ability of dazmegrel, a novel thromboxane synthetase inhibitor, to protect against ischaemic necrosis in similar flaps has been assessed. No such protective effect could be demonstrated and a possible explanation of the earlier observations is offered.
D000818:Animals; D007093:Imidazoles / Q000627:therapeutic use*; D007511:Ischemia / Q000517:prevention & control*; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology; D013524:Surgical Flaps
D007093:Imidazoles; C039242:dazmegrel