Serum creatine-kinase-BB and brain damage in high-risk newborn infants. Preliminary study with a new method for CK-BB estimation.
CK-BB activity increases after hypoxic conditions associated with central nervous system disease. Fifty-four high-risk newborn babies were studied with serial measurements of CK-BB activities during the first 3 postnatal days. These values were correlated to their early neurologic outcome at 5 months of age. Data were carried out using a new and very sensitive method for estimating CK-BB activity and showed a good correlation between enzymatic values and the presence of persistent neurologic abnormalities (P less than .05). We conclude that early CK-BB determinations can be used as indicator of neonatal brain damage.
D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000209:etiology; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D002534:Hypoxia, Brain / Q000150:complications / Q000175:diagnosis*; D007231:Infant, Newborn; D007527:Isoenzymes; D011446:Prospective Studies; D012306:Risk
D007527:Isoenzymes; D003402:Creatine Kinase