N-benzyl-4-phenyl-1,2,3-triazole derivatives as in vitro inhibitors of the prostaglandin synthesis.
Numerous N-benzyl-4-phenyl-1,2,3-triazole derivatives were synthesized and tested. The compounds were prepared by nucleophilic substitution, 1,3-dipolar cycloaddition and usual functional group conversion reactions. Several derivatives were evaluated in vitro for their ability to inhibit prostaglandin synthesis and to displace labelled [14C] indomethacin from bovine vesicular gland microsomes. Some compounds showed biological activity.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D001593:Benzyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D001667:Binding, Competitive / Q000187:drug effects; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D007213:Indomethacin / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011448:Prostaglandin Antagonists / Q000138:chemical synthesis*; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D001593:Benzyl Compounds; D011448:Prostaglandin Antagonists; D014230:Triazoles; D008315:Malondialdehyde; D007213:Indomethacin