[Changes in the levels of reverse triiodothyronine (rT3) during and after surgery of the thyroid gland].
The thyroid activity of twenty euthyroid patients, with single or multiple "cold" nodules was investigated, with determination of seric T3, T4, reverse-T3 (rT3) and TSH. The blood-drags were performed respectively, during (with seric samples from the inferior thyroid vein ipsilateral to the affected lobe) and after (1, 3 and 7 days) surgery. The results of this study--and particularly the significative decrease of T3 and the rapid rT3 increase, either during or after operation - suggests a condition similar to the described "Low T3 syndrome", as expression of both the stress determined by surgery and the correlated thyroid metabolic "adaptation". The clinical and biochemical euthyroidism, expressed by normal levels of TSH in all the samples, confirm the persistence of normal feed-back mechanism by the diencephalon-hypophysis-thyroid axis, even in stress conditions.
D000222:Adaptation, Physiological; D000328:Adult; D004027:Diencephalon / Q000503:physiopathology; D005246:Feedback; D005260:Female; D006801:Humans; D008297:Male; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D011184:Postoperative Period; D013312:Stress, Physiological / Q000503:physiopathology; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000503:physiopathology / Q000601:surgery*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood; D014285:Triiodothyronine, Reverse / Q000097:blood*
D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D013972:Thyrotropin; D013974:Thyroxine
Variazioni dei livelli di reverse-T3 (rT3) nel corso e dopo interventi chirurgici sulla tiroide.