Effect of acetaldehyde on urinary salsolinol in healthy man after ethanol intake.
The effect of acetaldehyde on urinary salsolinol (6, 7-dihydroxy-l-methyl-1,2,3,4-tetrahydroisoquinoline) after ethanol intake was investigated. Healthy Japanese male volunteers were divided into two groups, i.e., a normal aldehyde dehydrogenase (ALDH) group of 13 subjects with a low Km isozyme of ALDH and a deficient group of 12 subjects. The subjects were given 0.4 or 0.8 g/kg of ethanol. Blood ethanol and acetaldehyde levels, urinary excretions of salsolinol, norepinephrine, epinephrine and dopamine were determined. A significant elevation of salsolinol in urine was found after intake of 0.8 g/kg of ethanol in the two groups, but the increase in the deficient group was greater than that in the normal group, while 0.4 g/kg of ethanol did not affect the excretion of salsolinol in either group. Blood acetaldehyde was highly correlated with urinary salsolinol (r = 0.88, p less than 0.001) and the correlation coefficient was greater than that between blood ethanol and salsolinol.
D000079:Acetaldehyde / Q000097:blood / Q000494:pharmacology*; D000328:Adult; D002395:Catecholamines / Q000652:urine; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007546:Isoquinolines / Q000652:urine*; D008297:Male
D002395:Catecholamines; D007546:Isoquinolines; D000431:Ethanol; C036617:salsolinol; D000079:Acetaldehyde