Biosynthesis of immunoreactive inhibin-like material (IR-ILM) by rat prostate.
Presence of biologically active inhibin-like material (ILM) in the rat prostate was demonstrated by suppression of in vitro follicle-stimulating hormone release from rat pituitaries, and its in vitro biosynthesis was studied by immunoprecipitation of 3H-leucine incorporated in ILM. In vitro biosynthesis of immunoreactive ILM (IR-ILM) was greater in prostate from castrated as compared to intact rats and it decreased in prostates from castrated rats treated with testosterone. In prostates from estrogen-treated castrated animals, an increase in IR-ILM synthesis was observed. These observations indicated that in addition to the testes prostate could be an additional source of ILM and that IR-ILM synthesis in prostate is modulated by hormones.
D000367:Age Factors; D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D007106:Immune Sera / Q000276:immunology; D007265:Inhibins / Q000096:biosynthesis* / Q000276:immunology; D008297:Male; D009919:Orchiectomy; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*; D011817:Rabbits / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology
D007106:Immune Sera; D013739:Testosterone; D004958:Estradiol; D007265:Inhibins