Evaluation of two compounds as possible radioprotectors.
Radioprotecting effectiveness of S-[2-(diethylamino)ethyl] 4-methylbenzothiohydroximate hydrochloride (Dev-B-9) and S-[2-(diethylamino)ethyl]alpha-keto 4-methyl benzothiohydroximate hydrochloride (Dev-B 43) were evaluated by both survival studies in mice exposed to 10.5 Gy whole body gamma-irradiation and 24 hours deoxycytidine (CdR) excretion in urine of rats following 5 Gy irradiation. The drugs were tested after intraperitoneal (i.p.) administration. The drugs rendered significant protection in sublethal (5 Gy) irradiation but could not protect against 10.5 Gy exposure.
D000818:Animals; D003841:Deoxycytidine / Q000652:urine; D005069:Evaluation Studies as Topic; D008297:Male; D051379:Mice; D010091:Oximes / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control* / Q000652:urine; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D010091:Oximes; D011837:Radiation-Protective Agents; D003841:Deoxycytidine; C048878:S-(2-(diethylamino)ethyl) alpha-keto-4-methylbenzothiohydroximate; C048877:S-(2-(diethylamino)ethyl) 4-methylbenzothiohydroximate