Effects of dopaminergic drugs on plasma levels of steroid hormones in conscious dogs.
Progesterone, cortisol and testosterone levels were measured by radioimmunoassay in peripheral venous blood of conscious dogs. I.v. injections of the dopamine receptor agonists apomorphine (0.05 mg/kg) and bromocriptine (0.1 mg/kg) increased progesterone levels (and cortisol levels, as previously shown) in dogs of both sexes. The response to apomorphine was abolished by pretreatments with peripheral dopamine receptor antagonists (domperidone and halopemide). Progesterone and cortisol responses to the dopamine receptor agonists were parallel, but the ratio of concentration was 1/100. Testosterone levels were not modified. These results suggest that the dopamine receptor agonists stimulate progesterone release from the adrenal glands at a site functionally accessible to the peripheral dopamine receptor antagonists. In addition, the neuroleptic haloperidol (0.1 mg/kg) was shown to cause long lasting increases of progesterone levels.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001971:Bromocriptine / Q000494:pharmacology; D004285:Dogs; D004294:Domperidone / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D011374:Progesterone / Q000097:blood*; D011863:Radioimmunoassay; D011954:Receptors, Dopamine / Q000378:metabolism; D012737:Sex Factors; D013739:Testosterone / Q000097:blood*
D011954:Receptors, Dopamine; D001971:Bromocriptine; D013739:Testosterone; D011374:Progesterone; D004294:Domperidone; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine; D006854:Hydrocortisone