Cephalosporin-induced hypoprothrombinemia: is the N-methylthiotetrazole side chain the culprit?
The reported high incidence of vitamin-K-reversible hypoprothrombinemia associated with the new beta-lactamase-stable cephalosporins prompted us to evaluate the effect on hemostasis of three cephalosporins (cefamandole, ceftriaxone, and ceftazidime) in 30 patients with serious infections. Cefamandole and ceftriaxone, both containing a sulfhydryl group, induced a significant and similar prolongation of prothrombin time and decrease in factor VII activity. Ceftazidime, in contrast, had no effect on these two parameters.
D001393:Azoles / Q000009:adverse effects*; D001424:Bacterial Infections / Q000188:drug therapy; D002511:Cephalosporins / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007020:Hypoprothrombinemias / Q000139:chemically induced*; D008297:Male; D011517:Prothrombin Time; D013329:Structure-Activity Relationship; D013777:Tetrazoles / Q000009:adverse effects*
D001393:Azoles; D002511:Cephalosporins; D013777:Tetrazoles; C038625:1-N-methyl-5-thiotetrazole