Lactate utilization by the neonatal rat brain in vitro. Competition with glucose and 3-hydroxybutyrate.
The maximum rates of lactate oxidation and lipogenesis from lactate by early-neonatal brain slices were considerably greater than those for utilization of glucose and 3-hydroxybutyrate at physiological concentrations. Lactate inhibited glucose utilization, but enhanced 3-hydroxybutyrate utilization. 3-Hydroxybutyrate inhibited lactate and glucose utilization. Glucose slightly inhibited oxidation of lactate and 3-hydroxybutyrate, but scarcely enhanced lipogenesis from these substrates.
D020155:3-Hydroxybutyric Acid; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006885:Hydroxybutyrates / Q000378:metabolism; D066298:In Vitro Techniques; D007773:Lactates / Q000378:metabolism*; D019344:Lactic Acid; D051381:Rats; D011919:Rats, Inbred Strains
D006885:Hydroxybutyrates; D007773:Lactates; D019344:Lactic Acid; D005947:Glucose; D020155:3-Hydroxybutyric Acid