The effect of a macrolide antibiotic against experimental sinusitis.
The effect of a macrolide antibiotic on experimentally induced sinusitis in rabbits was evaluated. Compared with the control group, the effect on sinus mucosal pathology was significantly superior in the drug-treated groups. Inflammation models as used in the present study will contribute to the establishment of a suitable pharmacotherapy for sinusitis.
D000818:Animals; D007933:Leucomycins / Q000627:therapeutic use*; D008443:Maxillary Sinus; D008855:Microscopy, Electron, Scanning; D015644:Miocamycin / Q000031:analogs & derivatives*; D009297:Nasal Mucosa / Q000473:pathology; D011817:Rabbits; D012852:Sinusitis / Q000188:drug therapy* / Q000473:pathology
D007933:Leucomycins; D015644:Miocamycin; C033383:rokitamycin