Refractory hyperdynamic shock associated with alcohol and disulfiram.
After massive alcohol intake, a patient under disulfiram therapy developed a severe cardiovascular collapse unresponsive to dopamine but successfully reversed with norepinephrine. Resistance to dopamine could be related to norepinephrine depletion caused by disulfiram. Norepinephrine could, therefore, represent the treatment of choice of these life-threatening conditions.
D004221:Disulfiram / Q000009:adverse effects*; D004298:Dopamine / Q000627:therapeutic use; D000431:Ethanol / Q000009:adverse effects; D006323:Heart Arrest / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000627:therapeutic use*
D000431:Ethanol; D004221:Disulfiram; D004298:Dopamine; D009638:Norepinephrine