The comparative effects of cortisol and voltaren on anaemia and temperature changes in experimental Trypanosoma brucei infection in rats.
Three groups of rats were infected with Trypanosoma brucei. Two of the groups were treated with either asteroidal (Cortisol) or a non-steroidal (Voltaren) anti-inflammatory drug to compare the effects of the two drugs on the disease process. The anaemia was least severe in the Cortisol treated group which suggests that its supportive use in the treatment of natural infections with the brucei subgroup of trypanosomes may be advantageous.
D000740:Anemia / Q000209:etiology* / Q000503:physiopathology; D000818:Animals; D001810:Blood Volume; D001831:Body Temperature / Q000187:drug effects*; D004008:Diclofenac / Q000627:therapeutic use*; D004906:Erythrocyte Count; D006400:Hematocrit; D006854:Hydrocortisone / Q000627:therapeutic use*; D007958:Leukocyte Count; D008297:Male; D051381:Rats; D014346:Trypanosoma brucei brucei; D014353:Trypanosomiasis, African / Q000188:drug therapy* / Q000503:physiopathology
D004008:Diclofenac; D006854:Hydrocortisone