[Sensitivity of the intestinal microflora of patients to antimicrobial preparations studied in order to conduct rational antibiotic treatment].
The oral administration of amikacin, ampiox, nystatin to CBA mice and the external treatment of the animals with 1% chlorhexidine solution makes it possible to create the germ-free state in the animals which must be then kept in a sterile box. If such animals receive the decantate of the patient's feces, introduced in a single administration, the microflora, which is subsequently formed in the intestine of the recipient animals, is identical to the donor's microflora. This permits the rapid and accurate determination of the sensitivity of the patient's intestinal microflora to different antimicrobial preparations and their combinations. The antibacterial preparations, effectively suppressing the patient's intestinal anaerobic opportunistic microflora in the intestine of the recipient mice, produce, if subsequently prescribed for treatment, a pronounced corrective effect on such microflora in the patient's intestine.
D000293:Adolescent; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D002648:Child; D003666:Decontamination / Q000379:methods; D004359:Drug Therapy, Combination; D005243:Feces / Q000382:microbiology; D005856:Germ-Free Life / Q000187:drug effects; D006801:Humans; D007410:Intestinal Diseases / Q000188:drug therapy / Q000382:microbiology; D007422:Intestines / Q000382:microbiology*; D051379:Mice; D008808:Mice, Inbred CBA; D008826:Microbial Sensitivity Tests / Q000379:methods; D013997:Time Factors
D000900:Anti-Bacterial Agents
Izuchenie chuvstvitel'nosti mikroflory kishechnika bol'nykh k protivomikrobnym preparatam s tsel'iu provedeniia ratsional'nogo lecheniia antibiotikami.