title: Tumor localization and biodistribution of 99mTc-muramylpolypeptide (MPP) in the rat.
abstract: Muramylpolypeptide, extracted from Nocardia opaca bacteria and originally designed for immunotherapy of malignant tumors, proved to localize in malignant tumors, when labeled with 99mTc. In the tumor-bearing rat 99mTc-muramylpolypeptide (MPP) showed a fast turnover and optimum tumor to soft tissue ratios were obtained as early as between 30-60 min after application. The uptake mechanism in malignant tumors remains uncertain.
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D002279:Carcinoma 256, Walker / Q000000981:diagnostic imaging*; D009368:Neoplasm Transplantation; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D015609:Organotechnetium Compounds; C048928:technetium Tc 99m muramylpolypeptide; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D013667:Technetium