Edrophonium: an aid in the diagnosis of acute organophosphate poisoning.
Unsuspected accidental cutaneous exposure to an organophosphate insecticide caused flaccid paralysis in a 10-year-old girl. Electromyogram demonstrated repetitive compound muscle action potentials in response to a single stimulus of nerve; decremental response, more prominent at higher rates of stimulation; worsening of decremental response after edrophonium injection; and normal nerve conduction velocities. Electromyogram with repetitive nerve stimulation and an edrophonium test may provide a simple and rapid method for diagnosis of acute organophosphate poisoning.
D000200:Action Potentials; D000208:Acute Disease; D002648:Child; D004491:Edrophonium; D004576:Electromyography; D005260:Female; D006801:Humans; D008743:Methyl Parathion / Q000506:poisoning*; D010278:Parathion / Q000031:analogs & derivatives*
D008743:Methyl Parathion; D010278:Parathion; D004491:Edrophonium