title: Radiation in combination with intra-arterial infusion therapy with dacarbazine for metastatic malignant melanoma localized to a lower extremity.
abstract: Fourteen patients with metastatic malignant melanoma localized to a lower extremity were treated with combined radiotherapy and intra-arterial infusion therapy with dacarbazine. All lesions that were included in radiation fields regressed completely. Two patients relapsed within radiation fields and six relapsed elsewhere. One patient had a serious intimal lesion caused by the catheter.
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000556:secondary; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D009364:Neoplasm Recurrence, Local; D011859:Radiography; D012878:Skin Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy
chemical_list: D003606:Dacarbazine