Effect of adrenergic stimulation on ornithine decarboxylase activity in the rat spleen.
The effect of a single administration of catecholamines on ornithine decarboxylase activity and polyamine biosynthesis in the rat spleen was investigated. Isoproterenol elicited a dose-dependent increase in spleen ODC activity which reached a maximum 4 hr after the administration of the drug. Putrescine content was also found to increase within a few hours, whereas S-adenosylmethionine decarboxylase activity and spermidine and spermine levels did not change significantly. Adrenaline and noradrenaline proved to be even more effective in increasing splenic ODC activity than isoproterenol. alpha- and beta-adrenergic antagonists prevented the ODC increase by catecholamines to a different extent.
D012437:Adenosylmethionine Decarboxylase / Q000378:metabolism; D000818:Animals; D002395:Catecholamines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology*; D007700:Kinetics; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011073:Polyamines / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000201:enzymology*
D002395:Catecholamines; D011073:Polyamines; D009955:Ornithine Decarboxylase; D012437:Adenosylmethionine Decarboxylase; D007545:Isoproterenol