Behavioral effects of CGS 8216 alone, and in combination with diazepam and pentobarbital in dogs.
Beagle dogs (N = 3) responded under a multiple fixed-interval (FI) 300 sec, fixed-ratio (FR) 30 schedule of food presentation. The pyrazoloquinoline derivative CGS 8216, given either intravenously (0.01-3.0 mg/kg) or orally (0.1-30.0 mg/kg) had little effect on either the rate or temporal pattern of responding during either component. Both diazepam (0.3 to 17.5 mg/kg, PO) and pentobarbital (0.1-17.5 mg/kg, PO) produced qualitatively similar effects on behavior. Rates of responding during the FI components first increased, then decreased with increasing doses; both drugs produced only dose-related decreases in the rate of responding during the FR components. CGS 8216 antagonized some of the behavioral effects of diazepam; FI and FR response rates returned to baseline, however the effects of diazepam on quarter-life values were not appreciably altered by CGS 8216. The effects of pentobarbital on schedule-controlled responding were not antagonized by CGS 8216. These results indicate CGS 8216 is a selective benzodiazepine antagonist that does not produce benzodiazepine-like behavioral effects.
D000284:Administration, Oral; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D003975:Diazepam / Q000037:antagonists & inhibitors*; D004285:Dogs; D004347:Drug Interactions; D007275:Injections, Intravenous; D010424:Pentobarbital / Q000008:administration & dosage*; D011720:Pyrazoles / Q000008:administration & dosage / Q000494:pharmacology*; D012055:Reinforcement Schedule
D011720:Pyrazoles; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one; D010424:Pentobarbital; D003975:Diazepam