[Effect of the amount of protein and calcium in the diet on cadmium chloride distribution and accumulation in the body when administered by different routes].
The authors studied distribution and accumulation of cadmium chloride after its intravenous (i. v.) or intragastric (i. g.) administration to experimental rats, which received diets with varying content of protein (18, 30 and 5%) and calcium (0.6, 2.4, 0.1%), during one month. A high level of cadmium chloride was recorded in the liver after i. v., and in the kidneys after i. g. administration. The highest level of cadmium chloride was observed in the kidneys after i. g. administration to rats which were given diets with high protein content. A balanced content of protein and calcium in the diet promoted diminution of cadmium chloride accumulation in the body.
D000284:Administration, Oral; D000818:Animals; D002104:Cadmium / Q000008:administration & dosage / Q000378:metabolism*; D019256:Cadmium Chloride; D002118:Calcium / Q000172:deficiency; D002136:Calcium, Dietary / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D007275:Injections, Intravenous; D008297:Male; D011488:Protein Deficiency / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D002136:Calcium, Dietary; D004044:Dietary Proteins; D002104:Cadmium; D019256:Cadmium Chloride; D002118:Calcium
Vliianie kolichestva belka i kal'tsiia v ratsione na raspredelenie i nakoplenie kadmiia khlorida v organizme pri razlichnykh putiakh ego vvedeniia.