Causes of organic dementia: a necropsy survey of 60 cases.
The neuropathological findings in all demented patients who were necropsied at the Sir Charles Gairdner Hospital during a 10-year period were reviewed. Of a total of 60 cases, 44 (73.3%) had the typical changes of Alzheimer's disease, while a variety of other conditions accounted for the remaining 16 cases--neoplasms (four patients); lacunar disease (four patients); viral infections (three patients: herpes simplex in two and Creutzfeldt-Jakob disease in one); non-specific brain atrophy (two patients); and single cases of Huntington's chorea, subdural haematomas and methotrexate-induced leucoencephalopathy. Associated cerebral pathologies were found in 17 (38.6%) of the cases of Alzheimer's disease and included vascular lesions (eight cases), subdural haematomas (six cases) and Wernicke's encephalopathy (two cases).
D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D002544:Cerebral Infarction / Q000473:pathology; D003704:Dementia / Q000209:etiology* / Q000473:pathology; D005260:Female; D006408:Hematoma, Subdural / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000209:etiology*; D009929:Organ Size; D013702:Temporal Lobe / Q000473:pathology