title: The effect of single and multiple dose therapy with azelastine on the immediate asthmatic response to allergen provocation testing.
abstract: The effect of 2.2 or 4.4 mg of azelastine administered orally on immediate allergen-induced airflow obstruction was studied in 20 young patients with asthma. Provocation testing was performed after a single oral dose of azelastine or placebo and repeated after 3 weeks of twice daily therapy with azelastine or placebo. After multiple dose therapy with 4.4 mg of azelastine for 21 days, significantly more allergen was required to produce a 35% fall in specific airways conductance than after placebo therapy (p less than 0.008). Apart from a "bitter, metallic" taste in the mouth reported by 41.2% of the patients while they were receiving azelastine, no other unwanted effects were encountered.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D000485:Allergens; D001249:Asthma / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008925:Mites / Q000276:immunology; D010793:Phthalazines / Q000008:administration & dosage* / Q000009:adverse effects; D011724:Pyridazines / Q000008:administration & dosage*
chemical_list: D000485:Allergens; D010793:Phthalazines; D011724:Pyridazines; C020976:azelastine