title: Biomembranes as models for polymer surfaces. IV. ESCA analyses of a phosphorylcholine surface covalently bound to hydroxylated substrates.
abstract: Using a simple chemical process, phosphorylcholine has been deposited covalently on the surface of a variety of hydroxylated polymers as a stable, monomolecular coating. Our goal was to obtain new biomaterials which, due to the chemical similarity of the modified interfaces to the phospholipid head groups present on the extracellular surfaces of blood cell membranes, should exhibit enhanced haemo- and biocompatibility. Our previous analyses by chemical and spectrophotometric methods indicated that sufficient quantities of phosphorylcholine were deposited on glass and silica surfaces to result in appreciable modification of their interfacial properties. In the present study, we have examined a series of modified hydroxylated substrates by ESCA and demonstrate specific chemical modifications on the molecular surfaces of polymeric substrates.
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006900:Hydroxylation; D008563:Membrane Lipids / Q000032:analysis*; D008566:Membranes; D008954:Models, Biological; D010713:Phosphatidylcholines / Q000032:analysis*; D011108:Polymers; D013052:Spectrometry, X-Ray Emission; D013499:Surface Properties
chemical_list: D008563:Membrane Lipids; D010713:Phosphatidylcholines; D011108:Polymers