[Comparative analysis of the drinking behavior of rats after microinjections of angiotensin II and bradykinin into the cerebral ventricles and instillations on the conjunctiva of the eye].
The effects of angiotensin-II and bradykinin intracerebroventricular microinjections and instillations on the conjunctiva on water and alcohol consumption in rats were compared. The identical effects of peptide instillations on the conjunctiva and intracerebroventricular microinjections were demonstrated. Dipsogenic doses of angiotensin-II for instillations on the conjunctiva in intact rats were greater than or equal to 10 micrograms. At the same time the effective peptide doses in drinking rats were similar to intracerebroventricular drug doses.
D000428:Alcohol Drinking; D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001920:Bradykinin / Q000008:administration & dosage / Q000494:pharmacology*; D003228:Conjunctiva; D004327:Drinking Behavior / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D008845:Microinjections; D051381:Rats; D011919:Rats, Inbred Strains
D000804:Angiotensin II; D001920:Bradykinin
Sravnitel'nyĭ analiz pit'evogo povedeniia krys pri mikroin''ektsiiakhangiotenzina-II i bradikinina v bokovye zheludochki mozga i instillatsiiakh ikh na kon''iunktivu glaza.