title: Fatty acyl-CoA oxidase in rat kidney and liver after application of thyroxine.
abstract: Male rats were fed a standard diet containing 2.5 mg% L-thyroxine. After 10 and 20 days, in postnuclear fractions of the kidney the specific activity of fatty acyl-CoA oxidase, the enzyme responsible for the rate-limiting first step of peroxisomal fatty acid beta-oxidation, was increased by 100 and 160%, respectively. A similar effect was found in the liver. It is suggested that thyroxine essentially affects only this step of the fatty acid beta-oxidation sequence. Presumably the elevation of fatty acyl-CoA oxidase is one reason for the beneficial action of thyroid hormones in toxic lesions of the kidney.
mesh_terms: D000214:Acyl Coenzyme A / Q000378:metabolism; D042962:Acyl-CoA Oxidase; D000818:Animals; D002332:Carnitine O-Acetyltransferase / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects; D007668:Kidney / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008830:Microbodies / Q000201:enzymology; D009243:NAD / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*
chemical_list: D000214:Acyl Coenzyme A; D009243:NAD; C010701:crotonyl-coenzyme A; D010088:Oxidoreductases; D042962:Acyl-CoA Oxidase; D002332:Carnitine O-Acetyltransferase; D013974:Thyroxine