Experimental posterior perforating ocular injury: a controlled study of the gross effects of localised gamma irradiation.
A pilot study on the effect of localised irradiation applied to the site of a standard perforating injury in the rabbit eye, showed that gamma rays limited the formation of post-traumatic vitreoretinal membranes. A controlled study was therefore undertaken to confirm this observation. Twenty-four pairs of rabbits underwent a standard perforating injury in the right eye. One rabbit of each pair received a radioactive ophthalmic Cobalt applicator and the other a dummy applicator. Nineteen of 24 non-irradiated eyes developed vitreoretinal membranes, with associated traction retinal detachment. Only four of 24 irradiated eyes developed traction retinal detachment.
D000818:Animals; D005123:Eye / Q000528:radiation effects*; D005131:Eye Injuries / Q000503:physiopathology*; D005260:Female; D005720:Gamma Rays; D008297:Male; D008566:Membranes; D008938:Mitosis / Q000528:radiation effects; D011817:Rabbits; D012160:Retina / Q000528:radiation effects; D012163:Retinal Detachment / Q000517:prevention & control; D013997:Time Factors; D014822:Vitreous Body / Q000528:radiation effects; D014945:Wound Healing / Q000528:radiation effects; D014950:Wounds, Penetrating / Q000503:physiopathology*