Mechanical and biochemical properties of human articular cartilage from the femoral head after subcapital fracture.
Articular cartilage from the femoral heads of 27 patients having an arthroplasty for subcapital fracture was studied, and its mechanical and chemical properties compared to those of a group of 33 age-matched macroscopically normal autopsy specimens. Water and proteoglycan contents were measured, as were swelling ability, compressive and tensile strength of the cartilage, and the density of the underlying bone. Cartilage from the fracture specimens had a significantly reduced proteoglycan content, as measured by fixed charge density, and increased swelling ability. These results indicate that this group differs from the "normal" population and care should be taken before they are accepted as control material for studies on osteoarthritic cartilage. Another finding was that bone density was much the same in the fracture and the normal group. This casts some doubt upon the concept that patients who sustain subcapital fractures are more osteoporotic than the average for the same age range.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002358:Cartilage, Articular / Q000032:analysis* / Q000502:physiology; D002648:Child; D003720:Densitometry; D005270:Femur Head / Q000293:injuries*; D006620:Hip Fractures / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D010003:Osteoarthritis / Q000503:physiopathology; D011509:Proteoglycans / Q000032:analysis
D011509:Proteoglycans