title: Lack of effect of influenza vaccine on warfarin anticoagulation in the elderly.
abstract: Influenza vaccine may inhibit hepatic metabolism of drugs and has been reported to prolong the prothrombin time in patients receiving warfarin by affecting the coagulation pathway. In a group of seven elderly residents of a long-term care facility who were receiving warfarin, prolongation of the prothrombin and partial thromboplastin times could not be shown up to 5 weeks after vaccination against influenza. The results were similar in nine elderly subjects who were not receiving warfarin.
mesh_terms: D000368:Aged; D006801:Humans; D007252:Influenza Vaccines / Q000009:adverse effects*; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D013997:Time Factors; D014859:Warfarin / Q000627:therapeutic use*
chemical_list: D007252:Influenza Vaccines; D014859:Warfarin