Effect of selected inhibitors on growth, pigmentation, and aflatoxin production by Aspergillus parasiticus.
We have treated a wild type strain of Aspergillus parasiticus with several known aflatoxin inhibitors in hopes of finding specific metabolic blocks in the aflatoxin biosynthetic pathway. In defined medium, benzoic acid (2 and 3 mg/ml), cinnamon (1 mg/ml), and sodium acetate (5 mg/ml) were fungitoxic. Benzoic acid (0.5 and 1 mg/ml), chlorox (5 microliters/ml), and dimethyl sulfoxide (5 microliters/ml) did not affect dry weight or mycelial pigmentation. Sodium benzoate (1, 2, 4 and 8 mg/ml) added after 2 days growth inhibited aflatoxin production in two defined media. We were unable to confirm previously published reports that an uncharacterized yellow pigment accumulates with benzoate-inhibition of aflatoxin biosynthesis.
D000085:Acetates / Q000494:pharmacology; D019342:Acetic Acid; D000348:Aflatoxins / Q000096:biosynthesis*; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D001565:Benzoates / Q000494:pharmacology; D019817:Benzoic Acid; D002935:Cinnamomum zeylanicum; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D010858:Pigmentation / Q000187:drug effects; D012973:Sodium Hypochlorite / Q000494:pharmacology
D000085:Acetates; D000348:Aflatoxins; D000935:Antifungal Agents; D001565:Benzoates; D019817:Benzoic Acid; D012973:Sodium Hypochlorite; D019342:Acetic Acid; D004121:Dimethyl Sulfoxide