Septal deafferentation enhances the neurotrophic effects of rat hippocampus on cultured neural cells from the central nervous system.
Neurotrophic effects (NTEs) of various brain regions of 4-week-old rats were examined in primary culture of rat embryonic cerebral hemispheres. Extracts of the hippocampus, brainstem and septal nucleus highly enhanced the survivability of neuronal cells and the division of non-neuronal cells by 9 days. The septohippocampal tract (fimbria fornix) was cut and the effect on the neurotrophic activity in the hippocampus was examined. The NTEs of hippocampal extracts remained unchanged 3 days after septal deafferentation, was significantly increased by 7 days, peaked at 14 days and returned to the basal level by 21 days.
D000818:Animals; D001923:Brain Chemistry; D002478:Cells, Cultured; D002490:Central Nervous System / Q000166:cytology / Q000502:physiology*; D003714:Denervation; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006651:Histocytochemistry; D007120:Immunochemistry; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D051381:Rats; D012688:Septum Pellucidum / Q000502:physiology*; D014020:Tissue Extracts / Q000494:pharmacology
D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D014020:Tissue Extracts