Increased N-pentane excretion in humans: a consequence of pulmonary oxygen exposure.
Lipid peroxidation by free radicals has been suggested as a mechanism of a lung injury caused by breathing higher than normal concentrations of oxygen. The appearance of hydrocarbons such as n-pentane in the expired gas of mammals has been proposed as in vivo evidence of lipid peroxidation. The excretion of n-pentane was studied in 15 healthy volunteers in whom excretion of exogenous n-pentane was determined over a 60- to 90-min period while breathing hydrocarbon-free gases. N-pentane elimination rates (mean +/- SEM) in the expired gas at 0, 30, 60, 90, and 120 min were 10.2 +/- 1.5, 1.6 +/- 0.2, 1.2 +/- 0.9, 1.3 +/- 0.4, and 1.3 +/- 0.3 (pmol X kg-1 X min-1), respectively. Using a specially assembled circuit, a 2-h oxygen exposure study was performed on six healthy volunteers, in whom basal n-pentane excretion varied ten-fold among individuals, from 0.25 to 2.25 pmol X kg-1 X min-1. After breathing 100% oxygen, n-pentane excretion was augmented 62-420% within 30 to 120 min. The authors conclude that lipid peroxidation may occur in humans within 30 min of breathing 100% oxygen.
D000328:Adult; D001944:Breath Tests; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000633:toxicity*; D010420:Pentanes / Q000378:metabolism*; D013997:Time Factors
D008054:Lipid Peroxides; D010420:Pentanes; C033353:pentane; D010100:Oxygen