Bronchodilating plasma concentrations of enprofylline and theophylline have minor cardiovascular effects in man.
The cardiovascular effects with bronchodilating plasma concentration of theophylline (3.8-12.6 mg/l) and enprofylline (0.8-3.0 mg/l) were studied in six healthy male subjects by means of non-invasive procedures. With these plasma concentrations only minor effects were noted with regard to heart rate, blood pressure and systolic time intervals. However, both xanthines seem to have a vasodilating ability and a weak positive inotropic effect on the heart.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001993:Bronchodilator Agents / Q000494:pharmacology*; D004311:Double-Blind Method; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D013806:Theophylline / Q000097:blood / Q000494:pharmacology*; D014970:Xanthines / Q000097:blood / Q000494:pharmacology*
D001993:Bronchodilator Agents; D014970:Xanthines; D013806:Theophylline; C034347:enprofylline