[Clinical effectiveness and pharmacokinetic characteristics of cefotaxime in premature infants with pneumonia].
Satisfactory efficacy of cefotaxime in treatment of premature infants with pneumonia during the first month of their life was shown. Dosing of the drug was studied. It was noted that the filtration function of the kidneys in the newborn premature infants influenced the blood levels of cefotaxime and its renal excretion.
D002439:Cefotaxime / Q000378:metabolism / Q000627:therapeutic use*; D003404:Creatinine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000378:metabolism; D007700:Kinetics; D008297:Male; D011014:Pneumonia / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors
D003404:Creatinine; D002439:Cefotaxime
Klinicheskaia éffektivnost' i nekotorye osobennosti farmakokinetiki tsefotaksima u nedonoshennykh deteĭ, bol'nykh pnevmonieĭ.