Projection of nucleus tractus solitarius units influenced by hepatoportal afferent signal to parabrachial nucleus.
In urethan-chloralose anesthetized rats, units in the nucleus tractus solitarius (NTS) which antidromically responded to electrical stimulation of the parabrachial nucleus (PB) were investigated for their responses to hepatic-vagal afferent signals. Among 63 NTS units examined, 25 (40%) were excited, 17 (27%) inhibited and the remaining 21 (33%) unaffected by single shock electrical stimulation of the hepatic branch of the vagus nerve. Topical application of Na+ produced an increase in discharge rate of 9 units and a decrease in 5 units. Portal infusion of hypertonic saline produced an increase in discharge rate of 3 units and a decrease in 5 units. Furthermore, 3 units responded to both topical application of Na+ and portal infusion of hypertonic saline.
D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005154:Facial Nerve / Q000502:physiology; D005930:Glossopharyngeal Nerve / Q000502:physiology; D008099:Liver / Q000294:innervation*; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D010525:Peripheral Nerves / Q000502:physiology*; D011149:Pons / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic; D012964:Sodium / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology
D012462:Saline Solution, Hypertonic; D012964:Sodium