title: Phagocytic activity of macrophages of rainbow trout against Vibrio anguillarum and the opsonising effect of antibody and complement.
abstract: The phagocytosis of Vibrio anguillarum by peritoneal macrophages from normal rainbow trout was enhanced by antibody and complement. Treatment of either macrophages or the bacteria by antibody also enhanced opsonisation. Five weeks after immunisation with V anguillarum, the phagocytic activity of macrophages from rainbow trout was increased significantly compared with the activity of those from unvaccinated fish. Although agglutinin titres did not increase until three weeks after immunisation, seven out of 10 fish challenged one week after immunisation survived, indicating that immunised fish had developed resistance to vibrio infection before significant levels of antibody or phagocytic activity became detectable.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D003165:Complement System Proteins / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D009895:Opsonin Proteins / Q000276:immunology*; D010529:Peritoneal Cavity / Q000166:cytology; D010587:Phagocytosis; D012487:Salmonidae / Q000276:immunology*; D014337:Trout / Q000276:immunology*; D014733:Vibrio / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D009895:Opsonin Proteins; D003165:Complement System Proteins