Scopolamine disrupts leverpress shock escape learning in rats.
Five groups of rats were tested on a discrete-trial leverpress shock escape task 30 min following an intraperitoneal injection of either 0 (saline), 0.2, 1.0, or 5.0 mg/kg scopolamine hydrobromide, or 5.0 mg/kg methylscopolamine hydrobromide. The results indicated that scopolamine, but not methylscopolamine, disrupted escape performance and this disruption was dose-related. These findings are consistent with both disinhibition and reduced freezing explanations of anticholinergic effects and support the view that reduced acetylcholine is involved in the behavioral effects of septal lesions.
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004924:Escape Reaction / Q000187:drug effects; D008297:Male; D019832:N-Methylscopolamine; D010275:Parasympathetic Nervous System / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012601:Scopolamine / Q000494:pharmacology*; D012602:Scopolamine Derivatives / Q000494:pharmacology; D012688:Septum Pellucidum / Q000502:physiology
D012602:Scopolamine Derivatives; D012601:Scopolamine; D019832:N-Methylscopolamine