Beneficial effect of colchicine in a case of sclerosing cholangitis.
A patient with ulcerative colitis and primary sclerosis cholangitis confirmed by liver biopsy and endoscopic retrograde cholangiography presented with severely altered liver function tests. A month of steroid treatment for the colitis symptoms had no effect on the liver function tests, and colchicine, 1 mg/day, was added. After 3 months of this combined treatment, improvement of the liver function tests was noted and progressed to complete normalization of all liver function tests at the end of a 2-year period of follow-up. On further follow-up, the patient remained asymptomatic and with normal liver function tests for an additional 3 years. Further controlled studies would be worthwhile to evaluate the possibility of treatment of primary sclerosis cholangitis with colchicine with or without steroids.
D000328:Adult; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002761:Cholangitis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D003078:Colchicine / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000150:complications; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D012598:Sclerosis
D003078:Colchicine