Cross hepatotoxicity between tricyclic antidepressants.
Cross hepatotoxicity between drugs in very uncommon. We report the case of a patient in whom acute hepatitis was induced by a tricyclic antidepressant, amineptine, and recurred early after administration of another tricyclic antidepressant, clomipramine. This observation suggests that the tricyclic ring is involved in the mechanism of the deleterious effect of both drugs to the liver.
D000208:Acute Disease; D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002997:Clomipramine / Q000009:adverse effects*; D003986:Dibenzocycloheptenes / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D006801:Humans
D000929:Antidepressive Agents, Tricyclic; D003986:Dibenzocycloheptenes; C011597:amineptin; D002997:Clomipramine