Prevention of flap necrosis by chlorpromazine.
Chlorpromazine administered to Sprague-Dawley rats 30 minutes prior to elevation of McFarlane back flaps and continued 14 days thereafter resulted in near complete flap survival, compared with 48 percent necrosis in control animals. Chlorpromazine demonstrates a wide variety of actions that appear to meet all presently known requirements for flap preservation.
D000818:Animals; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006085:Graft Survival / Q000187:drug effects*; D007279:Injections, Subcutaneous; D008297:Male; D009336:Necrosis / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D013524:Surgical Flaps; D013997:Time Factors
D002746:Chlorpromazine