Renal and hepatic interactions between 2-hexanone and carbon tetrachloride in F-344 rats.
Fisher-344 rats were pretreated with 2-hexanone (HX) and challenged with carbon tetrachloride (CCl4) in a replicated 3 X 4 factorial experiment to determine if HX potentiated CCL4-induced renal and hepatic damage. Rats given both HX and CCl4 demonstrated more severe hepatic injury at 24 and 48 h than did controls. However, in contrast to our experience with chloroform (CHCl3), CCl4-induced renal injury in HX-pretreated rats was only slightly greater than in vehicle-pretreated controls.
D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D002251:Carbon Tetrachloride / Q000633:toxicity*; D003401:Creatine / Q000032:analysis; D004357:Drug Synergism; D007659:Ketones / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008742:Methyl n-Butyl Ketone / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344
D007659:Ketones; D008742:Methyl n-Butyl Ketone; D002251:Carbon Tetrachloride; D000410:Alanine Transaminase; D003401:Creatine