[Diagnostic and prognostic significance of so-called rheumatoid vasculitis--2].
51 patients with rheumatoid arthritis and high rheumatoid factors (mean titres 928) underwent examination for the demonstration of an extraarticular organ manifestation within the scope of the cooperation between the Department of Medicine of the Karl-Marx-University Leipzig and the Institute for Rheumatology of the Academy of Medical Sciences of the USSR in Moscow. The frequency of nodous rheumatism (about 60%) is comparable with the frequency of polyneuropathy. In 20% of the patients a systemic muscle atrophy, a hepatomegaly as well as a Raynaud-syndrome were stated. By means of skin biopsy in 28% perivascular infiltrates were found. Altogether in 6 patients (12%) a participation of the lungs and the pleura, respectively, could be proved. Only rarely a clinically manifest heart disease caused by the rheu-we we found an pericardial effusions in 3 cases. In systemic manifestation, such as myositis, participation of the eyes or vasculitis of the digital arteries with necrosis, were only sporadically to be established. Among 22 patients we found an pericardial effusions in 3 cases. In systemic manifestation in most cases increased parameters of activity were found. From the practical point of view apart from increased titers of the rheumatoid titres and circulating immune complexes (C1q-BT) increased concentrations of the C-reactive protein are prognostically significant. The presence of high rheumatoid factor titres alone as well as the isolated presence of rheumatic nodes must not always be connected with an unfavourable prognosis. When severe extraarticular manifestations are present a possibly early, intensive occasionally extracorporeal treatment is indicated.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000175:diagnosis*; D001706:Biopsy; D002097:C-Reactive Protein / Q000032:analysis; D002196:Capillaries / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009133:Muscular Atrophy / Q000175:diagnosis; D010490:Pericardial Effusion / Q000175:diagnosis; D011115:Polyneuropathies / Q000175:diagnosis; D011379:Prognosis; D011928:Raynaud Disease / Q000175:diagnosis; D012217:Rheumatoid Factor / Q000032:analysis; D012867:Skin / Q000098:blood supply; D014657:Vasculitis / Q000175:diagnosis*
D000936:Antigen-Antibody Complex; D002097:C-Reactive Protein; D012217:Rheumatoid Factor
Zur diagnostischen und prognostischen Bedeutung der sog. rheumatoiden Vaskulitis--2. Mitteilung.