The predictive value of animal experimentation for clinical geropsychopharmacology.
An overall view is presented of the most used models in aged and in young (deficient and standard) animals as well as of some so-called pro-geriatric manipulations. Life-span studies, electrophysiological (EEG and evoked potentials) and behavioural models are discussed. Particular emphasis is placed upon the complex correlations (electrophysiological and behavioural) between animal (rodents and mammals) and human pharmacology in the field of interhemispheric, mainly callosal, connection.
D000375:Aging / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002415:Cats; D003337:Corpus Callosum / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D007858:Learning / Q000187:drug effects; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D011760:Pyrrolidinones; D010889:Piracetam