[Participation of immune mechanisms in the development of microangiopathies in patients with non-insulin-dependent diabetes mellitus].
Biopsies of the thigh skin from 145 patients with immuno-independent diabetes mellitus were studied morphologically. Diabetical microangiopathy was found in 123 patients. IgG, IgM, complement, albumin, beta-lipoproteins, fibrinogen were determined immunohistochemically in the walls of altered vessels. The frequency of IgG fixation of the vascular wall and its level in the serum were significantly higher than in patients without alteration of small vessels. The conclusion on the leading role of plasmatic inhibition in the development of diabetic microangiopathy and on the participation of not only metabolic but also immune (immunocomplex most likely) mechanisms in its development is drawn.
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology* / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D008297:Male; D008833:Microcirculation / Q000276:immunology* / Q000378:metabolism; D008875:Middle Aged; D012867:Skin / Q000098:blood supply*
D000936:Antigen-Antibody Complex; D001798:Blood Proteins; D007136:Immunoglobulins
Ob uchastii immunnykh mekhanizmov v razvitii mikroangiopatii u bol'nykh insulinonezavisimym sakharnym diabetom.