In vivo effect of a high-cholesterol diet on the endothelial integrity of rat aorta.
A new technique for measuring spontaneous or induced endothelial lesions in animals was used to analyse the endothelial integrity of the aortas of rats fed a normolipidic or high-cholesterol diet. Animals fed a hypercholesterolic diet for 7 days differed from animals fed a normolipidic diet in that they presented endothelial lesions in accordance with the lipid hypothesis of atherosclerosis.
D000818:Animals; D001011:Aorta / Q000473:pathology*; D001161:Arteriosclerosis / Q000209:etiology* / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage* / Q000494:pharmacology; D004727:Endothelium / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051381:Rats
D002791:Cholesterol, Dietary; D002784:Cholesterol