title: Indoprofen-induced aplastic anemia in active connective tissue disease detected by drug-specific lymphocyte transformation.
abstract: In connective tissue diseases, the differentiation of disease-related hematological aberrations from drug-induced cytotoxic or allergic blood-cell dyscrasias is often difficult. In this paper we report on the positive identification of an indoprofen-induced severe pancytopenia in a multi-drug-treated patient with active systemic lupus erythematosus by use of a drug-specific lymphocyte transformation test.
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced; D000741:Anemia, Aplastic / Q000139:chemically induced*; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000209:etiology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007216:Indoprofen / Q000009:adverse effects* / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008213:Lymphocyte Activation / Q000187:drug effects*; D010198:Pancytopenia / Q000139:chemically induced; D010666:Phenylpropionates / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000139:chemically induced
chemical_list: D010666:Phenylpropionates; D007216:Indoprofen