Liposome delivery of NMR contrast agents for improved tissue imaging.
Large unilamellar liposomes containing the paramagnetic contrast agent manganese chloride were shown to selectively enhance the intensity of the proton NMR signal from the livers of experimental mice. The kinetics of the observed effect indicate that the liposomes are rapidly removed from the circulation and deposited in high concentration within the liver. This process is known to involve the phagocytic activity of macrophages. These results show that liposomes could provide a useful and efficient vehicle for delivering NMR contrast agents to organs like the liver, spleen, and bone marrow. It may also be possible to use liposomes to selectively deliver contrast agents to tissue regions of developing pathology that are rich in macrophage activity.
D000818:Animals; D002712:Chlorides; D003287:Contrast Media / Q000008:administration & dosage*; D008081:Liposomes / Q000008:administration & dosage*; D008099:Liver / Q000033:anatomy & histology; D009682:Magnetic Resonance Spectroscopy; D008345:Manganese; D017895:Manganese Compounds; D051379:Mice; D010587:Phagocytosis
D002712:Chlorides; D003287:Contrast Media; D008081:Liposomes; D017895:Manganese Compounds; D008345:Manganese; C025340:manganese chloride