Mechanisms of contact photosensitivity in mice. VII. Diminished elicitation by reserpine and defective expression in mast cell-deficient mice.
The involvement of mast cells in the elicitation of contact photosensitivity (CPS) was examined in mice treated with pharmacologic agents and in genetically mast cell-deficient W/Wv mice. Contact photosensitivity responses were diminished by pretreatment with reserpine, which may have been due to depletion of vasoactive amines in mast cells. This inhibition was almost reversed by the monoamine oxidase inhibitor, pargyline-HCl, which prevented reserpine-induced depletion of vasoactive amines such as serotonin. Defective CPS was also found in W/Wv mice, but not in their congenic littermates (+/+). Abnormal CPS in mast cell-deficient mice was due to a defect in the elicitation of CPS rather than a defect in the induction of effector T cells, since the ability to elicit CPS could be transferred to normal +/+ mice by photosensitized cells from mast cell-deficient mice. These findings favor the view that mast cells are involved in the elicitation of CPS.
D000818:Animals; D006968:Hypersensitivity, Delayed / Q000276:immunology / Q000503:physiopathology; D007116:Immunization, Passive; D008297:Male; D008407:Mast Cells / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010293:Pargyline / Q000494:pharmacology; D010787:Photosensitivity Disorders / Q000276:immunology / Q000503:physiopathology*; D012110:Reserpine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012458:Salicylanilides / Q000276:immunology; D012701:Serotonin / Q000378:metabolism
D012458:Salicylanilides; D012701:Serotonin; D012110:Reserpine; D010293:Pargyline; C003390:3,3',4',5-tetrachlorosalicylanilide