Anisodamine induces the hexagonal phase in phospholipid liposomes.
The effects of anisodamine on the polymorphic phase behaviour of cardiolipin and dioleoylphosphatidylcholine liposomes have been investigated by freeze-fracture electron microscopy. Anisodamine induces the formation of lipidic particles in cardiolipin liposomes at pH 7.0 and hexagonal HII tubes at pH 8.8. When the molar ratio of anisodamine and dioleoylphosphatidylcholine is 4 to 1, lipidic particles can be observed in the fracture faces.
D002308:Cardiolipins; D005614:Freeze Fracturing; D008081:Liposomes; D008854:Microscopy, Electron; D010713:Phosphatidylcholines; D012991:Solanaceous Alkaloids / Q000494:pharmacology*
D002308:Cardiolipins; D008081:Liposomes; D010713:Phosphatidylcholines; D012991:Solanaceous Alkaloids; C003922:anisodamine; C017251:1,2-oleoylphosphatidylcholine