title: [Nature of the stimulating substances found in the vital activity products of yeastlike fungi].
abstract: The cultural broth of Candida tropicalis was shown to contain an active compound which stimulated the synthesis of levorin, a polyene antibiotic Succinic acid was found to stimulate the antibiotic synthesis. The stimulating effect of the active compound increased in proportion to the content of succinic acid in it and became maximal at the same concentration of succinic acid as in a pure preparation. However, succinic acid was not an only compound responsible for the elevated synthesis of the antibiotic since the biostimulating effect was higher than that of pure succinic acid.
mesh_terms: D001419:Bacteria / Q000378:metabolism; D002174:Candicidin / Q000096:biosynthesis; D003470:Culture Media / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005285:Fermentation / Q000187:drug effects; D050356:Lipid Metabolism; D008055:Lipids / Q000494:pharmacology; D013268:Stimulation, Chemical; D013302:Streptomyces / Q000187:drug effects / Q000378:metabolism; D013386:Succinates / Q000378:metabolism / Q000494:pharmacology; D019802:Succinic Acid; D015003:Yeasts / Q000378:metabolism*
chemical_list: D003470:Culture Media; D008055:Lipids; D013386:Succinates; D002174:Candicidin; D019802:Succinic Acid
vernacular_title: Priroda stimuliruiushchikh veshchestv, soderzhashchikhsia v produktakh zhiznedeiatel'nosti drozhzhepodobnykh gribov.