Analysis of translocations observed in three different populations. II. Robertsonian translocations.
A sample of 229 Robertsonian translocations was classified into three groups according to the method of their ascertainment (Group I = couples with repeated abortions; Group II = karyotypically unbalanced probands; Group III = balanced translocation heterozygotes). Statistical analysis showed that the distributions of Robertsonian translocations differed significantly from random in all three groups. Additionally, the distributions were significantly different between couples with repeated abortions and karyotypically unbalanced probands and between unbalanced probands and balanced translocation heterozygotes.
D000022:Abortion, Spontaneous / Q000235:genetics; D002871:Chromosome Banding; D005260:Female; D006579:Heterozygote; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D014178:Translocation, Genetic