Oral absorption of flucloxacillin in infants and young children.
The bioavailability of flucloxacillin (Heracillin) following oral administration was determined in infants and children. After a dose of 12.5 mg/kg, peak concentrations were achieved at 60 min. which declined rapidly and were low in older children only 4 hours afterwards. Infants below 6 months of age showed a better absorption when given the mixture than older children. Older children achieved higher plasma concentrations when given tablets than when given equal doses of the mixture. There was no difference in the concentration when the dose was given to the subject when fasting, or with breakfast.
D000284:Administration, Oral; D000367:Age Factors; D002675:Child, Preschool; D003023:Cloxacillin / Q000031:analogs & derivatives*; D005436:Floxacillin / Q000008:administration & dosage / Q000378:metabolism*; D005502:Food; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007408:Intestinal Absorption
D005436:Floxacillin; D003023:Cloxacillin