Effect of dietary malathion on hepatic microsomal drug-metabolizing systems of Gallus domesticus.
White leghorn cockerels were fed a diet containing 0, 400, 800 and 1600 ppm of malathion for 90 days. Malathion O,O-dimethyl S-(1,2-dicarbethoxy) ethyl phosphorodithioate) at 800 and 1600 ppm caused a significant decrease in body weights. There was a significant increase in liver/body weight ratio. A marked inhibition of aniline hydroxylation and demethylation of p-chloro N-methyl aniline was observed in the 9000 X g supernatant fraction of liver. Protein contents of liver supernatant of the treated group were significantly lower than control. Plasma half-lives of antipyrine in cockerels receiving malathion at 800 and 1600 ppm were considerably increased. Pentobarbital sleeping time was longer in malathion-treated cockerels.
D000284:Administration, Oral; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D000983:Antipyrine / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002645:Chickens; D006900:Hydroxylation; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008294:Malathion / Q000633:toxicity*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects
D000814:Aniline Compounds; C011716:4-chloro-N-methylaniline; D006899:Mixed Function Oxygenases; D010424:Pentobarbital; D000983:Antipyrine; D008294:Malathion