title: [Therapy of idiopathic thrombocytopenic purpura].
abstract: Various treatment strategies for acute and chronic idiopathic thrombocytopenic purpura (ITP) in childhood are reviewed. In acute ITP steroids induce a prompt improvement of symptoms and a rapid increase in platelet count; the use of high dose intravenous immunoglobulin is a valid alternative treatment to steroids. In chronic ITP splenectomy is still the most successful treatment, as it induces remission in 60-80% of patients. The risk for severe infections after splenectomy is still considerable in children; therefore other treatment schedules are suggested (i.v. immunoglobulin, courses of steroids, high dose methylprednisolone). In this paper we report 100 pediatric cases with acute ITP and 36 with chronic ITP.
mesh_terms: D000208:Acute Disease; D002543:Cerebral Hemorrhage / Q000209:etiology; D002908:Chronic Disease; D003348:Cortisone / Q000627:therapeutic use; D006801:Humans; D007116:Immunization, Passive; D011241:Prednisone / Q000627:therapeutic use; D011696:Purpura, Thrombocytopenic / Q000150:complications / Q000628:therapy*; D013156:Splenectomy; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D003348:Cortisone; D011241:Prednisone
vernacular_title: Terapia delle porpore trombocitopeniche idiopatiche.