title: A note on Shirley's nonparametric test for comparing several dose levels with a zero-dose control.
abstract: Shirley (1977, Biometrics 33, 386-389) proposed a nonparametric version of Williams' test for determining the lowest dose level at which there is evidence of a toxic effect. A modification of Shirley's procedure is now proposed, which improves its power.
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D001699:Biometry; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions; D008954:Models, Biological