[Photodynamic therapy (PDT) of bladder cancer in the rat].
PDT of rat bladder cancer, induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) was studied. All animals were divided at random into three groups. Group 2 and 3 were treated by hematoporphyrin derivative (HPD)-laser PDT while group 1, without treatment, served as control. The results showed that the malignant lesions could be selectively and obviously destroyed, if the whole tumor area were sufficiently exposed to the laser irradiation. However, the normal bladder epithelium and muscle layer showed no histologic change. Similar reactions were found in papilloma of bladder which was considered as precancerous lesion. Thus, PDT may be beneficial to cancer prevention. Its role in prevention and treatment of bladder cancer should be further studied experimentally and clinically.
D000818:Animals; D002085:Butylhydroxybutylnitrosamine; D005260:Female; D006414:Hematoporphyrin Photoradiation / Q000379:methods; D006415:Hematoporphyrins / Q000627:therapeutic use*; D010212:Papilloma / Q000188:drug therapy; D010778:Photochemotherapy / Q000379:methods; D051381:Rats; D011919:Rats, Inbred Strains; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000188:drug therapy*
D006415:Hematoporphyrins; D002085:Butylhydroxybutylnitrosamine