title: Penicillamine-induced exacerbation of rheumatoid arthritis.
abstract: We have described three patients whose rheumatoid arthritis was exacerbated by penicillamine. The exacerbation was manifested as severe, disabling, febrile, symmetric polysynovitis with normocomplementemia, negative ANA, and reversibility upon discontinuance of the drug. The pathogenesis is yet to be determined.
mesh_terms: D000208:Acute Disease; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000008:administration & dosage / Q000009:adverse effects*; D013585:Synovitis / Q000503:physiopathology
chemical_list: D010396:Penicillamine