The effect of new adamantane derivatives on experimental influenza infection in mice.
Two newly synthesized derivatives of 1-aminoadamantane hydrochloride--CF.01.01 and CF.01.06--were assayed for their anti-influenza efficacy. Aqueous solutions of the drugs (200 gamma/0.1 ml) were administered intranasally to mice at 24 hours and 5 hours or at 24 hours, 5 hours and 1 hour prior to intranasal inoculation of influenza virus A/PR/8/34 (H1N1). Compound CF.01.06 caused a significant decrease of the HA titer in the lungs of virus-infected mice. There was no change in mortality rate and the increase in mean survival time was at the limit of statistical significance.
D000547:Amantadine / Q000627:therapeutic use*; D000818:Animals; D002264:Carboxylic Acids / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006389:Hemagglutinins, Viral / Q000032:analysis; D009980:Influenza A virus / Q000276:immunology; D008168:Lung / Q000276:immunology; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000401:mortality
D002264:Carboxylic Acids; D006389:Hemagglutinins, Viral; D000547:Amantadine