title: Particle spallation induced by blood pumps in hemodialysis tubing sets.
abstract: The repeated flexion and compression of pump segments by the rollers of peristaltic pumps results in cracking and abrasion of the inner surfaces of the pump segment, leading to shedding of particles into the extracorporeal circuit. A series of studies to assess the rate of particle release from silicone rubber, polyvinyl chloride (PVC), and Pivipol, a coextruded polyurethane-coated PVC tubing, when these materials were used with blood pumps of the type found in hemodialysis units, was undertaken. The studies show that with all tubing/pump combinations there is an overall increase in the total number of particles released, but an analysis of the particle size distribution indicates that the majority of the particles are less than 16 micron in diameter. The rate of increase may be reduced, however, by decreasing the occlusion pressure.
mesh_terms: D000704:Analysis of Variance; D007688:Kidneys, Artificial; D010316:Particle Size; D011140:Polyurethanes; D011143:Polyvinyl Chloride; D006435:Renal Dialysis; D012826:Silicone Elastomers
chemical_list: D011140:Polyurethanes; D012826:Silicone Elastomers; D011143:Polyvinyl Chloride