title: Stimulation of rat bladder epithelial DNA synthesis by intravesical instillation of distilled water.
abstract: Two commonly used cystoscopic infusion fluids were examined to determine whether their infusion stimulates DNA synthesis of the bladder epithelium. Following a single intravesical dose of 0.5 ml of distilled water or 1.5% L-glycine solution, rats were killed periodically up to 1 week. A transient but significant increase in epithelial cell [3H]thymidine labeling was observed at 48 hr after distilled water instillation. Glycine solution did not stimulate DNA synthesis.
mesh_terms: D000818:Animals; D003558:Cystoscopy; D004247:DNA / Q000096:biosynthesis*; D004848:Epithelium; D005260:Female; D005998:Glycine; D051381:Rats; D012965:Sodium Chloride; D001743:Urinary Bladder / Q000378:metabolism; D014867:Water
chemical_list: D014867:Water; D012965:Sodium Chloride; D004247:DNA; D005998:Glycine