Influence of the application mode of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide on the localization of its carcinogenic expression in female NMRI-mice.
The administration of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide FANFT) by gavage to female NMRI-mice resulted in a high incidence of neoplasms of the forestomach. From 117 effective animals which were pooled from 3 dosed groups, 30 squamous cell carcinomas and 26/117 papillomas of the forestomach were diagnosed. Only 5/117 neoplasms of the urinary bladder occurred. The average cumulative dose administered was 1180 mg/mouse, and the mean latent period for the induction of forestomach tumours was 574 days. The mode of application seems to be an important factor in the carcinogenicity of FANFT.
D000230:Adenocarcinoma / Q000139:chemically induced*; D000284:Administration, Oral; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced*; D005200:FANFT / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D010212:Papilloma / Q000139:chemically induced*; D013274:Stomach Neoplasms / Q000139:chemically induced*; D013844:Thiazoles / Q000633:toxicity*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D013844:Thiazoles; D005200:FANFT