title: Myotonic dystrophy treated with selenium and vitamin E.
abstract: We have previously reported the successful treatment of a patient with myotonic dystrophy with selenium and vitamin E. This paper deals with the treatment of a further five patients with myotonic dystrophy in different stages. All five patients improved subjectively and objectively in two or more respects. All improved their grip strength according to vigorimeter measurements (Martin), two normalized their gait, another two can now sit down on their heels and stand up, one patient can now walk on his toes, one can now get up from lying on the floor without using a chair and two patients have improved their physical capacity. Patients in early stages of the disease improved faster and more markedly than those in late stages. Electromyographical measurements also showed improvements, in that the myotonic discharges had diminished. The daily dose was 4 mg of Na2SeO3 and 600 mg of vitamin E. Serum concentration of selenium increased in all patients at the beginning of the treatment, but stabilized at a level slightly above the normal. No side-effects were observed.
mesh_terms: D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement; D009119:Muscle Contraction; D009223:Myotonic Dystrophy / Q000188:drug therapy* / Q000503:physiopathology; D020887:Selenious Acid; D012643:Selenium / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D014810:Vitamin E; D020887:Selenious Acid; D012643:Selenium