New agents active against African swine fever virus.
Actinobolin, atropine, carrageenan, megalomycin C, suramin, and tetracenomycin C were tested for their activity against African swine fever virus replication. Both viral inhibitory potency and cytotoxicity were investigated. Megalomycin C, suramin, atropine, and carrageenan exhibited significant activity. Megalomycin C was the most active of the four agents with respect to the concentration of compound that blocked the formation of infectious virus by 50%. Suramin was the next most active agent in this respect, but because of its lower cytotoxicity, it had the most favorable therapeutic index.
D000358:African Swine Fever Virus / Q000187:drug effects* / Q000502:physiology; D000617:Aminoglycosides / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D002351:Carrageenan / Q000494:pharmacology; D002460:Cell Line; D002522:Chlorocebus aethiops; D003588:Cytopathogenic Effect, Viral; D007497:Iridoviridae / Q000187:drug effects*; D009279:Naphthacenes / Q000494:pharmacology; D011714:Pyrans; D013498:Suramin / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D009279:Naphthacenes; D011714:Pyrans; D013498:Suramin; C020938:tetracenomycin C; D001285:Atropine; D002351:Carrageenan; C100221:actinobolin