Is topical haloperidol a useful glaucoma treatment?
A randomised, double blind, single dose study of topical haloperidol, a dopamine receptor blocking drug, was performed on 20 healthy volunteers. After its administration a modest reduction in intraocular pressure was recorded over the six-hour study period, but the difference was not significant at the p less than 0.05 level. Although dopamine blocking agents are effective in reducing intraocular pressure in experimental animals, topical haloperidol appears unlikely to be clinically useful in the treatment of glaucoma.
D000287:Administration, Topical; D004311:Double-Blind Method; D005901:Glaucoma / Q000188:drug therapy; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007634:Keratitis / Q000139:chemically induced; D013997:Time Factors
D006220:Haloperidol