Pharmacokinetics of galanthamine hydrobromide (Nivalin) following single intravenous and oral administration in rats.
A study on galanthamine hydrobromide (Nivalin) pharmacokinetics was carried out on male Wistar rats following single intravenous and oral administration. Plasma samples were collected after decapitation of the animals. The drug concentrations were determined spectrophotofluorometrically. A two-compartment open model was found to describe best the experimental data. Galanthamine has an elimination half-life of 40-50 min, a volume of distribution over 2 liters/kg, a plasma clearance of about 2 liters/h X kg and an oral bioavailability of about 65%.
D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000378:metabolism; D005702:Galantamine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005702:Galantamine