Lack of relevance of kinetic parameters for exocellular DD-peptidases to cephalosporin MICs.
MICs of a set of cephalosporins against a variety of gram-positive and gram-negative pathogens showed no strong correlations with the rate at which these inhibitors acylate or are deacylated by beta-lactam-sensitive DD-peptidases excreted by Streptomyces sp. strain R61 and Actinomadura sp. strain R39.
D002268:Carboxypeptidases / Q000037:antagonists & inhibitors*; D002511:Cephalosporins / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D002267:Muramoylpentapeptide Carboxypeptidase / Q000037:antagonists & inhibitors*
D002511:Cephalosporins; D002268:Carboxypeptidases; D002267:Muramoylpentapeptide Carboxypeptidase