Postinjury changes in the biomechanics of nerves and roots in mice.
The biomechanical characteristics of sciatic nerve and associated spinal roots of mice were investigated. Both normal and postcrush nerve materials were tested in the same fashion using superimposed elongation, force and geometry data. The results show that nerve and roots differ considerably both in the force they sustain before failure and in the other biomechanics they exhibit. The nerves and associated structures transmit and absorb large amounts of force. The roots, in comparison, are mechanically frail but exhibit similar elongation before failure. The behavior of these elements of the nervous system are discussed with regard to implications for integrated nerve, root and spinal cord mechanical integrity.
D000818:Animals; D001696:Biomechanical Phenomena; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D012584:Sciatic Nerve / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology; D013126:Spinal Nerve Roots / Q000293:injuries* / Q000503:physiopathology; D013997:Time Factors