title: Nutrition of cruciate ligament reconstruction by diffusion. Collagen synthesis studied in rabbits.
abstract: The reconstructed anterior cruciate ligament was studied in the rabbit using the medial third of the patellar tendon. Tritiated proline, 100 microCi/kg body weight, was injected intra-articularly to insure detection of the metabolic conversion product 3H-hydroxyproline in the avascular graft. During the immediate postoperative period, nutrients were found to derive from the synovial fluid through a process of diffusion, demonstrating that synovial nutrition occurs prior to revascularization of the graft.
mesh_terms: D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D006909:Hydroxyproline / Q000378:metabolism; D007719:Knee Joint; D008023:Ligaments, Articular / Q000601:surgery*; D008297:Male; D011392:Proline / Q000378:metabolism; D011817:Rabbits; D013582:Synovial Fluid / Q000378:metabolism; D013710:Tendons / Q000378:metabolism* / Q000637:transplantation; D014316:Tritium
chemical_list: D014316:Tritium; D003094:Collagen; D011392:Proline; D006909:Hydroxyproline