title: Relaxation times of normal and atrophied muscle.
abstract: Magnetic resonance imaging is being used to investigate physiological changes induced by microgravity. Using human (bed rest) and animal (tail suspension) models simulating zero gravity, muscle atrophy was studied. Despite significant physiological changes in muscle mass, distribution of blood flow, and muscle water, no changes in muscle proton relaxation times were found at several different resonant frequencies (6, 10, 20, and 200 MHz). These results suggest that observed changes in relaxation times as reported in pathologic studies are likely due to the pathological changes and not the accompanying muscle atrophy.
mesh_terms: D000818:Animals; D001510:Bed Rest; D005260:Female; D006112:Gravitation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009132:Muscles / Q000033:anatomy & histology / Q000473:pathology*; D009133:Muscular Atrophy / Q000175:diagnosis* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D014893:Weightlessness