Effects of unilateral nephrectomy during early pregnancy.
Litter data and kidney growth parameters in Wistar rats uninephrectomized (UNX) or sham-operated (SO) on the 5th-7th day of gestation, and in unoperated controls (C) were investigated at 1 day and at 6 wk postpartum. Gestation period, litter size, sex ratio of pups, and pup weight at birth did not differ among the groups. At 6 wk, pups from UNX mothers displayed retarded growth. Compensatory kidney growth following UNX in pregnant rats was predictable for wet weight, but dry weight compensation was transient and limited.
D000818:Animals; D001724:Birth Weight; D005260:Female; D007668:Kidney / Q000254:growth & development*; D008098:Litter Size; D009392:Nephrectomy; D009929:Organ Size; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011270:Pregnancy, Animal; D051381:Rats; D011919:Rats, Inbred Strains