title: Biliary excretion of trichloroethylene and its metabolites in dogs.
abstract: To examine the biliary excretion of trichloroethylene (TRI) and its metabolites, we carried out various experiments with TRI and its metabolites, i.e., chloral hydrate (CH), free-trichloroethanol (F-TCE) and trichloroacetic acid (TCA), using anesthetized dogs. The amount of biliary excretion was significantly increased with the administration of CH and F-TCE, whereas it remained at control levels with the administration of TRI and TCA. The substances excreted into bile were conducted in the form of conjugated-TCE (Conj-TCE) in over 90% of the CH, F-TCE and TRI administration groups. About 95% of these Conj-TCE were conjugated with glucuronic acid. The cumulative excretion ratios of substances and metabolites to dose were 20% for CH and F-TCE, and about 1% for TCA and TRI 2 h after administration.
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D002697:Chloral Hydrate / Q000378:metabolism*; D002728:Chlorohydrins / Q000378:metabolism*; D004285:Dogs; D005023:Ethylene Chlorohydrin / Q000031:analogs & derivatives / Q000378:metabolism*; D005260:Female; D008297:Male; D014238:Trichloroacetic Acid / Q000378:metabolism*; D014241:Trichloroethylene / Q000378:metabolism*
chemical_list: D002728:Chlorohydrins; C044588:1,1,2-trichloroethanol; D014241:Trichloroethylene; D002697:Chloral Hydrate; D014238:Trichloroacetic Acid; D005023:Ethylene Chlorohydrin