Treatment of Felty's syndrome with low-dose oral methotrexate.
Recent studies of methotrexate in the treatment of patients with rheumatoid arthritis have precluded patients with neutropenia. We present a patient with rheumatoid arthritis complicated by severe neutropenia and recurrent infections, who was treated with low-dose methotrexate, orally, for 30 months. The patient experienced symptomatic improvement and a significant increase in granulocyte count, and the dosage of steroids was reduced. Low-dose oral methotrexate may be a therapeutic option in select patients with Felty's syndrome.
D000284:Administration, Oral; D000368:Aged; D002177:Candidiasis / Q000150:complications; D004941:Esophagitis / Q000209:etiology; D005258:Felty Syndrome / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D012852:Sinusitis / Q000150:complications; D013203:Staphylococcal Infections / Q000150:complications; D014552:Urinary Tract Infections / Q000150:complications
D008727:Methotrexate