[Clinical correlation and modification of the subrenal capsule assay].
A prospective study using 10 cases with miscellaneous tumors was performed. Discoid (columnar) tumors were measured three-dimensionally (volume method). Modified criteria for evaluability and for both absolute and relative quantitative sensitivities were employed. The evaluability was 9/10 (90%) and by the volume method true positives (more than PR) were 2/2, true negatives (less than PR) were 9/10 and overall predictive accuracy was 11/12 (92%), and accordance in relative sensitivity ranking (e.g. A drug is better than B drug) was seen in 4/4. However using the original method (mean diameter method) the corresponding figures were 0/0, 9/12, 9/12, (75%) and 2/4, respectively. The utility of this assay in the field of clinical chemotherapy therefore seems very promising.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical / Q000592:standards*; D006801:Humans; D007668:Kidney; D009369:Neoplasms / Q000188:drug therapy*; D011446:Prospective Studies
D000970:Antineoplastic Agents