Alloxan-induced changes in the collagen characteristics in the skin of male garden lizards, Calotes versicolor, from three age groups.
Alloxan diabetes in lizards Calotes versicolor, belonging to three age groups, induced decreased levels of percentage of solubility of collagen in dorsal and ventral skin regions after 7 days of treatment. Old lizards showed greater susceptibility to alloxan diabetes than lizards of the young and middle-age groups. There appears to be no correlation between blood-glucose level and accelerated ageing of collagen. It is suggested that, in alloxan diabetes, metabolites formed in the tissues might accelerate the ageing of collagen.
D000375:Aging; D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D003094:Collagen / Q000032:analysis*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008112:Liver Glycogen / Q000032:analysis; D008116:Lizards / Q000502:physiology*; D008297:Male; D012867:Skin / Q000032:analysis*; D012995:Solubility
D001786:Blood Glucose; D008112:Liver Glycogen; D000496:Alloxan; D003094:Collagen