Kinetics of heat-damaged homologous red blood cells in patients with homozygous beta-thalassemia in relation to blood transfusion.
The kinetics of heat-damaged homologous red blood cells (HDE) was studied prior to and 7-10 d following blood transfusion in 14 patients with homozygous beta-thalassemia. On the basis of our results, beta-thalassemic patients were classified into two distinct groups. In the first group the pretransfusion HDE extraction efficiency of the spleen was significantly lower than that of the second group and it increased dramatically following blood transfusion. On the contrary, the relatively higher pretransfusion HDE extraction efficiency of the patients of the second group showed a significant decrease after blood transfusion. These differences between the two groups of beta-thalassemics might be attributed to the different qualitative as well as quantitative alterations of the splenic vascular bed occurring in these patients during the course of their disease. Furthermore, there was convincing evidence that part of the HDE mixture was extracted by RES sites outside the spleen, a function which is also affected by blood transfusion.
D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006720:Homozygote; D006358:Hot Temperature; D006801:Humans; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D012039:Regional Blood Flow; D013154:Spleen / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D013789:Thalassemia / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy