Perisinusoidal cells in patients with normal liver histology. A morphometric study.
We measured the number and the morphometric characteristics of perisinusoidal cells in perfusion-fixed biopsy samples from 7 control patients with normal liver histology. On 1-micron section, the number of cells was 18 +/- 1.5/0.1 mm2; 25% of cells did not apparently contain lipids. There were no significant zonal differences. The volume density of the cells represented 1 +/- 0.2% of the hepatic parenchyma. On ultrathin sections, the volume and surface densities of processes were 3.2 +/- 0.7% of sinusoid and 0.21 +/- 0.04 m2/cm3 of sinusoid respectively which represented 70% and 90% of total PSC volume and surface densities. Lipid volume density was 20.5 +/- 7.3% of the nucleated cell. More than 30% of cells contained less than 10% of lipids. There was no correlation between lipid volume density and RER surface density.
D000328:Adult; D000368:Aged; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000166:cytology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D014801:Vitamin A / Q000032:analysis
D008055:Lipids; D014801:Vitamin A