Demonstration of X chromatin in drumstick-like nuclear appendages of leukocytes by in situ hybridization on blood smears.
An X chromosome specific nucleic acid probe was used to study the positions of the X chromosomes in leukocyte nuclei by in situ hybridization to smears of peripheral blood. This autoradiographic approach allowed the first direct demonstration of the presence of X chromosomal material in the drumstick-like structures of female polymorphonuclear leukocytes.
D002467:Cell Nucleus / Q000032:analysis / Q000648:ultrastructure*; D002843:Chromatin / Q000032:analysis; D002901:Chromosomes, Human, 13-15; D006801:Humans; D009504:Neutrophils / Q000032:analysis / Q000648:ultrastructure*; D009693:Nucleic Acid Hybridization; D014314:Trisomy; D014960:X Chromosome / Q000032:analysis* / Q000648:ultrastructure
D002843:Chromatin