[Interaction of carbon disulfide (CS2 with ethanol in the microsomal monooxygenase system, and its biological consequences].
The interaction of CS2 and ethanol with microsomal monooxygenase and its biological consequences were studied in experimental model on rats exposed concurrently to CS2 (conc. 0,4-1,5 g/m3) and ethanol (10% water solution as the only drink) for 6 months. Prolonged treatment of rats with ethanol resulted in: stimulation of the activity of microsomal monooxygenases microsomal ethanol oxidizing system, increase of the cyt. P-450 level, intensification of lipid peroxidation as well as proliferation of smooth and degranulation of rough endoplasmic reticulum. Combined exposure of rats to CS2 and ethanol resulted in a significant potentation of the depressive effect of CS2 on cyt. P-450 dependent monooxygenases. The alterations induced by CS2, ethanol and both agents in the microsomal monooxygenases are consistent with the observed lipoproteins response.
D000815:Aniline Hydroxylase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D002246:Carbon Disulfide / Q000494:pharmacology*; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004347:Drug Interactions; D004721:Endoplasmic Reticulum / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D065607:Cytochrome P-450 Enzyme Inhibitors; D000431:Ethanol; D003577:Cytochrome P-450 Enzyme System; D000815:Aniline Hydroxylase; D001189:Aryl Hydrocarbon Hydroxylases; D002246:Carbon Disulfide
Interakcja dwusiarczku wegla (CS2) z etanolem w układzie mikrosomalnych monooksygenaz i jej skutki biologiczne.