title: Plasma exchange for acute cholestasis in homozygous sickle cell disease.
abstract: A child with sickle cell disease presented acute chest syndrome, acute cholestasis and a neurological syndrome. Bilirubin, LDH, alkaline phosphatase, urea and creatinines were markedly increased. Circulating immune complexes were slightly elevated. The patient improved dramatically after a plasma exchange.
mesh_terms: D000208:Acute Disease; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000032:analysis; D002648:Child; D002779:Cholestasis / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008297:Male; D010951:Plasma Exchange
chemical_list: D000936:Antigen-Antibody Complex