title: Changes in forebrain hexokinase activity after aortic baroreceptor denervation.
abstract: Although forebrain structures have been implicated in both the development and maintenance of the elevated arterial pressure (AP) after aortic baroreceptor denervation, little is known about the location of central structures involved in the hypertensive process. In the present study, regions of the forebrain whose metabolic activity was altered after aortic baroreceptor denervation were functionally identified using hexokinase (HK) histochemistry in the rat. Three days after bilateral aortic depressor nerve (ADN) transection AP was significantly elevated compared with sham ADN-transected animals (143 +/- 1 and 122 +/- 2 mmHg, respectively). Significant increases in HK activity were observed in the magno- and parvocellular components of the paraventricular nucleus of the hypothalamus, supraoptic nucleus, nucleus circularis, median preoptic nucleus, subfornical organ, and central nucleus of the amygdala in the ADN-transected animals. These data have demonstrated that removal of aortic baroreceptor afferent inputs alters the activity of forebrain structures previously implicated in regulation of body fluid balance and AP and suggest that these structures are involved in the hypertensive process after ADN transection.
mesh_terms: D000818:Animals; D001011:Aorta / Q000294:innervation*; D001794:Blood Pressure; D001921:Brain / Q000201:enzymology*; D003714:Denervation; D006339:Heart Rate; D006593:Hexokinase / Q000378:metabolism*; D006651:Histocytochemistry; D006973:Hypertension / Q000201:enzymology; D008297:Male; D011311:Pressoreceptors / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D006593:Hexokinase