C5 fragments: are they important in polymorphonuclear leucocyte diapedesis?
In the present study the coisogenic C5-sufficient B10.D2/nSn and C5-deficient B10.D2/oSn mice were used to determine the importance of the C5 molecule in the polymorphonuclear leucocyte accumulation in inflammatory sites. Peritoneal exudates were induced by carrageenin, glycogen, zymosan, endotoxin lipopolysaccharides (LPS) and via a passive immediate hypersensitivity reaction. It was found that the temporal profile of PMN accumulation induced by all inflammatory stimuli tested, except by high doses of LPS, is similar in C5-sufficient and C5-deficient strains of mice.
D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D002634:Chemotaxis, Leukocyte; D003182:Complement C5 / Q000172:deficiency / Q000378:metabolism*; D007249:Inflammation; D007700:Kinetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009504:Neutrophils / Q000502:physiology*
D003182:Complement C5