Pyrimidinones. 3. N-substituted 6-phenylpyrimidinones and pyrimidinediones with diuretic/hypotensive and antiinflammatory activity.
In an extensive analysis of the antiviral and interferon-induction structure-activity relationship of 6-arylpyrimidinones we found that modifications at positions 1-4 of the pyrimidine ring resulted in a loss of activity. However, we uncovered interesting hypotensive and antiinflammatory activity with a series of N-substituted analogues, the results of which we report herein.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001168:Arthritis / Q000188:drug therapy; D004231:Diuresis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D006145:Guanethidine / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D006852:Hydrochlorothiazide / Q000494:pharmacology; D007022:Hypotension / Q000139:chemically induced*; D008297:Male; D008745:Methylation; D009318:Natriuresis / Q000187:drug effects; D010648:Phenylacetates / Q000138:chemical synthesis / Q000378:metabolism* / Q000494:pharmacology; D011188:Potassium / Q000652:urine; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013267:Stilbenes / Q000138:chemical synthesis / Q000378:metabolism* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D010648:Phenylacetates; D011744:Pyrimidinones; D013267:Stilbenes; D013629:Tamoxifen; D006852:Hydrochlorothiazide; D005665:Furosemide; D011188:Potassium; D006145:Guanethidine