title: Beta-lactam/aminoglycoside combinations: interactions and their mechanisms.
abstract: Combinations of beta-lactams with aminoglycosides are widely used in the therapy of infections. There are a number of theoretic advantages to using such combinations. Indeed, combinations of beta-lactams and aminoglycosides usually result in synergism or indifference and very rarely in antagonism. The mechanisms of synergism, resistance to synergism, and antagonism have been studied extensively in enterococci; further studies are necessary to define such mechanisms in other organisms.
mesh_terms: D000617:Aminoglycosides / Q000008:administration & dosage / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D001770:Blood Bactericidal Activity / Q000187:drug effects; D004336:Drug Antagonism; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D008826:Microbial Sensitivity Tests; D047090:beta-Lactams
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D047090:beta-Lactams