Morphological anomalies in the lymph nodes of 13-month-old thymus-grafted nude mice.
The purpose of the present work was to investigate whether the grafting of a thymus to 7-day-old BALB/cByJ nude mice prevents the occurrence of the nodal anomalies recently observed in non-grafted nude mice. We found that the anomalies were still present, but attenuated, in the grafted mice. Furthermore, we observed differences between anomalies occurring in grafted and in non-grafted nude mice. The differences appear to be interrelated and to result from changes in the pattern of lymphocyte migration in the nodes of grafted nude mice, due to a lesser deficiency of the immune system.
D000818:Animals; D008198:Lymph Nodes / Q000098:blood supply / Q000166:cytology / Q000473:pathology*; D008214:Lymphocytes / Q000145:classification; D008407:Mast Cells / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D008819:Mice, Nude / Q000097:blood*; D010581:Peyer's Patches / Q000503:physiopathology; D013154:Spleen / Q000503:physiopathology; D013934:Thymectomy; D013950:Thymus Gland / Q000637:transplantation*