title: Successful use of clonazepam in patients with treatment-resistant panic disorder.
abstract: Ten cases are presented--two in detail--in which clonazepam was used successfully in patients with treatment-resistant panic disorder with or without agoraphobia. Seven of 10 patients who had been resistant to standard pharmacological treatments of panic attacks and agoraphobia achieved cessation of their attacks while three had mild to moderate symptom persistence. These data underscore other reports of clonazepam's usefulness in the treatment of panic disorder. Clinical use of clonazepam is discussed.
mesh_terms: D000328:Adult; D000379:Agoraphobia / Q000188:drug therapy / Q000523:psychology; D000525:Alprazolam; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000523:psychology; D001569:Benzodiazepines / Q000627:therapeutic use; D001570:Benzodiazepinones / Q000627:therapeutic use*; D002998:Clonazepam / Q000494:pharmacology / Q000627:therapeutic use*; D003891:Desipramine / Q000627:therapeutic use; D005239:Fear / Q000187:drug effects; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010200:Panic / Q000187:drug effects; D010624:Phenelzine / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D011569:Psychiatric Status Rating Scales
chemical_list: D001570:Benzodiazepinones; D001569:Benzodiazepines; D002998:Clonazepam; D011433:Propranolol; D010624:Phenelzine; D007099:Imipramine; D003891:Desipramine; D000525:Alprazolam