Influence of indomethacin on an increase in cerebral blood flow induced by KC-404, a novel cerebral vasodilator, in an anesthetized dog.
The effect of KC-404 on vertebral blood flow in the absence and presence of indomethacin was investigated in an anesthetized dog. KC-404 (0.2 mg/kg, i.v.) showed a significant and long lasting increase in vertebral blood flow. This was markedly diminished by pretreatment of the animal with indomethacin. The increase in heart rate due to KC-404 administration was also diminished, though moderately, by pretreatment with indomethacin. From these results, the possible mechanism of action of KC-404 was discussed, particularly in reference to cerebral vasodilating prostaglandins.
D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011725:Pyridines / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D014665:Vasodilator Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D014711:Vertebral Artery; D007212:Indolizines; D011720:Pyrazoles
D007213:Indomethacin; D011725:Pyridines; D014665:Vasodilator Agents; C038366:ibudilast; D007212:Indolizines; D011720:Pyrazoles