[Cellular proliferation of the regenerating liver in rats after a single administration of N-nitrosodiethylamine].
Proliferative kinetics of hepatocytes and nonparenchymal cells of the regenerating rat liver has been studied after a single injection of the carcinogen in S- or G2-M-phase cell cycle of hepatocytes. Disturbances of proliferation in the mentioned cell populations and resistance of normal proliferating hepatocytes during the S-phase of the mitotic cycle to the cytotoxic effect of the carcinogen are established. Possible mechanisms of the resistance of the proliferating cells to the toxic action of the carcinogen are discussed.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004052:Diethylnitrosamine / Q000633:toxicity*; D006918:Hydroxyurea / Q000494:pharmacology; D007399:Interphase / Q000187:drug effects; D008099:Liver / Q000166:cytology / Q000187:drug effects; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D008938:Mitosis / Q000187:drug effects; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D004052:Diethylnitrosamine; D010089:Oxidoreductases, N-Demethylating; D006918:Hydroxyurea
Proliferatsiia kletok regeneriruiushcheĭ pecheni krys posle odnokratnogo vvedeniia N-nitrozodiétilamina.