Debrisoquine oxidation in an Australian population.
The standard laboratory method for determination of debrisoquine phenotype has been modified and shortened with no loss of sensitivity. Debrisoquine metabolic ratios (MR) at 4 and 8 h showed excellent correlation indicating that collection time can also be shortened. Same day phenotyping is therefore possible. One hundred normal, Caucasian Australian subjects were phenotyped (46 males, 54 females) and 6% were poor metabolisers (PM) of debrisoquine. Fifty of the original subjects were also acetylation phenotyped and 34% were fast and 66% slow acetylators. One PM of debrisoquine was a fast acetylator of sulphadimidine and four PM were slow acetylators. This was a non-significant association.
D000107:Acetylation; D000293:Adolescent; D000328:Adult; D001315:Australia; D003647:Debrisoquin / Q000378:metabolism*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010641:Phenotype; D013418:Sulfamethazine / Q000378:metabolism; D014556:Urine / Q000032:analysis; D044465:White People
D007546:Isoquinolines; D013418:Sulfamethazine; D003647:Debrisoquin