[Changing of organ distribution of radioactive yttrium in rats by varying amounts of carrier].
There is little change in the organ distribution of yttrium citrate complex after addition of 0.01 mg/kg BW as carrier. Adding increasing amounts of inactive yttrium up to 1 mg/kg BW caused a considerable reduction in bone uptake and an increasing accumulation in the liver and spleen by transformation to colloid. Uptake in the lung indicates formation of macro-particles. The transformation into colloid can be varied by changing the citrate concentration. The 90Y-citrate complex for therapy should be used either without or with very little carrier of inactive yttrium.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002951:Citrates / Q000008:administration & dosage / Q000378:metabolism; D003102:Colloids; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D009942:Organometallic Compounds; D051381:Rats; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution; D015019:Yttrium / Q000008:administration & dosage / Q000378:metabolism*
D002951:Citrates; D003102:Colloids; D009942:Organometallic Compounds; D015019:Yttrium; C045937:yttrium citrate
Anderung der Organverteilung von radioaktivem Yttrium bei Ratten durch unterschiedlich hohe Trägermengen.