Prevention of amphotericin B-induced rigors by dantrolene.
Three patients had severe amphotericin B-induced rigors refractory to conventional prophylactic measures. Rigors improved or disappeared when dantrolene sodium was given prophylactically or during an episode. These observations suggest that dantrolene is useful as an alternative or adjuvant agent for severe rigors associated with amphotericin 3 infusion.
D000328:Adult; D000666:Amphotericin B / Q000009:adverse effects*; D003620:Dantrolene / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009127:Muscle Rigidity / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control*
D000666:Amphotericin B; D003620:Dantrolene