Effects of ethanol on methyl mercury toxicity in rats.
This study was designed to investigate the effect of different doses of ethanol on the morbidity, mortality, and distribution of mercury in the tissues of groups of rats treated orally once daily with methyl mercury chloride (MMC: 5 mg/kg . d) for 10 consecutive days. Ethanol potentiated the toxicity of methyl mercury in terms of neurological manifestations (hindleg crossings and abnormal gait) and mortality. The magnitude of effect depended on the concentration of ethanol administered. The concentration of mercury in the kidney and brain also increased with the dose of ethanol given. These findings indicate that epidemiologic studies designed to evaluate methyl mercury toxicity must take into account the multiple environmental burdens that can affect the population cumulatively and simultaneously.
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology*; D005684:Gait / Q000187:drug effects; D008297:Male; D008767:Methylmercury Compounds / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D008767:Methylmercury Compounds; D000431:Ethanol