Embryo resorption following administration of steroidal compounds to rats in mid pregnancy.
In the course of experiments on the effects of anabolic steroids on the myocardium of rat conceptuses, we found that subcutaneous implantation of 10 mg of estradiol, Dianabol or testosterone to rats in mid pregnancy, resulted in embryo resorption. Placental tissue was identified only in estradiol-treated rats which also demonstrated a large amount of serosanguineous fluid that dilated the horns considerably. The yellow nodules of placental attachment sites were represented histologically by cellular and vascular proliferations between the inner and outer layers of the myometrium. The nodular aggregates of cells had variable features according to the steroid administered. Neither decidual cells nor metrial glands that are reported to be the constituents of placental attachment sites were seen in our material. We conclude that anabolic steroids are potent agents for embryo resorption, and that the cells in the nodules of placental attachment sites are likely to be derived from the myometrium.
D000818:Animals; D020964:Embryo Loss / Q000139:chemically induced*; D004958:Estradiol / Q000633:toxicity*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D008696:Methandrostenolone / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000633:toxicity*; D014599:Uterus / Q000187:drug effects
D013739:Testosterone; D004958:Estradiol; D008696:Methandrostenolone