Relaxin increases calcium efflux from rat myometrial cells in culture.
Relaxin and isoproterenol treatment rapidly increased 45Ca2+ efflux from mature rat myometrial cells in culture in a time- and concentration-dependent manner. This effect on Ca2+ efflux was specific for myometrial cells and was not observed in stromal cells isolated from the same uteri. This rapidly exchangeable Ca2+ may be mobilized from a loosely bound peripheral Ca2+ pool in myometrial cells. Relaxin may promote uterine relaxation in part by affecting Ca2+ dynamics in the myometrium.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D009215:Myometrium / Q000187:drug effects* / Q000378:metabolism; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains; D012065:Relaxin / Q000494:pharmacology*
D012065:Relaxin; D007545:Isoproterenol; D002118:Calcium