title: Studies on the effect of experimental inflammation on sialyltransferase in the mouse and guinea pig.
abstract: The effect of inflammation on sialyltransferase was studied in the mouse and guinea pig. There was a three-fold increase in mouse liver sialyltransferase activity reaching a maximum at 72 hr after inflammation; serum levels were increased by five-fold at 72 hr after inflammation. The response of guinea pig sialyltransferase was slower and of lower magnitude compared with the response of the mouse enzyme; liver and serum sialyltransferase increased by about 50% reaching a maximum at 96 hr after inflammation. The specificity of the enzyme that responded to inflammation in the mouse and guinea pig was found to be Gal beta 1----4GlcNAc alpha 2----6 sialyltransferase, the same enzyme activity that was shown to be an acute phase reactant in earlier studies in the rat (Kaplan et al., 1983).
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex; D006168:Guinea Pigs; D007106:Immune Sera; D066298:In Vitro Techniques; D007249:Inflammation / Q000201:enzymology*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D051379:Mice; D051381:Rats; D012799:Sialyltransferases / Q000097:blood / Q000378:metabolism*; D013045:Species Specificity; D014166:Transferases / Q000378:metabolism*
chemical_list: D000936:Antigen-Antibody Complex; D007106:Immune Sera; D014166:Transferases; D012799:Sialyltransferases