Effects of linoleic acid and gamma-linolenic acid intake on platelet functions in elderly people.
Sixteen old subjects were given daily dietary supplement of lg of linoleic acid and lg of gamma-linolenic acid (primerose oil) or 2g of linoleic acid (sunflower oil) for periods of two months. Haemostatic parameters, platelet aggregation, exogenous and endogenous arachidonic acid metabolism were investigated before and after the intake. Diets did not induce any significant change in haemostatic parameters (bleeding time, levels of anti-thrombin III, plasminogen and plasma beta-TG and PF4). Platelet rich plasma aggregation induced by collagen and arachidonic acid were significantly reduced after linoleic acid (18:2n-6) intake. In contrast, gamma-linolenic acid (18:3n-6) supplement did not alter aggregation. However, thromboxane B2 formation (under stimulation) and vitamin E level in platelets (but not in plasma) were decreased after 18:3n-6 as compared to 18:2n-6 intake. The mechanism of thromboxane B2 decrease is unclear. Nevertheless, we may speculate that beneficial effect of this decrease could be counterbalanced by the decreased platelet vitamin E. We conclude that intake of 18:2n-6 or 18:3n-6 does not affect much platelet functions in elderly people.
D015126:8,11,14-Eicosatrienoic Acid / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D000284:Administration, Oral; D000368:Aged; D000375:Aging; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D004041:Dietary Fats / Q000008:administration & dosage; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D013929:Thromboxane B2 / Q000378:metabolism; D014810:Vitamin E / Q000097:blood
D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D014810:Vitamin E; D013929:Thromboxane B2; D019787:Linoleic Acid; D015126:8,11,14-Eicosatrienoic Acid