(+)-Cyanidanol-3 prevents the functional deterioration of rat liver mitochondria induced by Fe2+ ions.
The clinically effective hepatoprotective flavonoid, (+)-Cyanidanol-3, prevented the Fe2+-induced functional deterioration of rat liver mitochondria. Fe2+ treatment of mitochondria resulted in increased lipid peroxidation (MDA-formation), decreased mitochondrial membrane potential, impaired Ca2+ uptake capacity and caused large amplitude swelling of mitochondria. All of the consequences of Fe2+ treatment were inhibited by (+)-Cyanidanol-3 in a concentration dependent manner. The mitochondrial protective action of the drug is comparable with its free radical scavenging property.
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D002392:Catechin / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism; D005296:Ferrous Compounds / Q000494:pharmacology*; D007501:Iron / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects*; D010101:Oxygen Consumption; D011188:Potassium / Q000378:metabolism; D051381:Rats
D001578:Benzopyrans; D002712:Chlorides; D005296:Ferrous Compounds; D002392:Catechin; D007501:Iron; D011188:Potassium; D002118:Calcium