Binding of heparin to human platelet factor 4.
Platelet factor 4 is a small protein (Mr 7756) from the alpha-granules of blood platelets which binds strongly to and neutralizes the anticoagulant properties of heparin. From an analysis of X-ray crystallographic data a model for the binding of platelet factor 4 to heparin is proposed.
D001665:Binding Sites; D006493:Heparin / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D010978:Platelet Factor 4 / Q000502:physiology*; D011485:Protein Binding; D014961:X-Ray Diffraction
D010978:Platelet Factor 4; D006493:Heparin