Experimental free vascularized epiphyseal transplants.
Growth plates have been transferred both clinically and in experimental models since the end of the 19th century. Results have been unpredictable and frequently unsatisfactory due to postoperative ischemia. Modern microvascular techniques have minimized this problem and preservation of growth plate structure and function has been reported after replantation and free tissue transfers in children and immature animals. Experimental revascularized growth plate transplants were first reported in 1979. Viable orthotopic transfers are associated with rapid bony union, maintenance of radiological structure, and continued growth in length at near normal rates. Detailed studies have demonstrated a continuation of cell division, metabolic activities, and normal histology. Technetium bone scans have been a useful postoperative indicator of viability, and ischemic times of more than three hours can be tolerated. The behavior of heterotopic transplants has not yet been fully studied. Early attempts suggest that biomechanical problems may be troublesome.
D000818:Animals; D001846:Bone Development; D002648:Child; D004285:Dogs; D006132:Growth Plate / Q000637:transplantation*; D006801:Humans; D008866:Microsurgery / Q000379:methods; D011817:Rabbits; D014945:Wound Healing