Mexiletine: biphasic action on convulsive seizures in rodents.
Mexiletine, an antiarrhythmic drug, exerted a protective effect in mice against convulsive seizures induced by electroshock or the chemical convulsant, pentylenetetrazol, and against seizures induced in inbred audiosusceptible mice by a sound signal. Administered in large doses, mexiletine produced a hyperkinetic myoclonic syndrome of 30-60 min duration. The hyperkinesia could be controlled by dimethylaminoethanol, phenobarbital and by an experimental anticonvulsive agent, eboracin.
D000161:Acoustic Stimulation; D000818:Animals; D003642:Deanol / Q000494:pharmacology; D004597:Electroshock; D006948:Hyperkinesis / Q000139:chemically induced* / Q000517:prevention & control; D008297:Male; D008801:Mexiletine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009207:Myoclonus / Q000139:chemically induced; D010433:Pentylenetetrazole / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*
D011437:Propylamines; D008801:Mexiletine; D003642:Deanol; D010433:Pentylenetetrazole