Urine discoloration after acetaminophen overdose.
Three patients with acetaminophen overdose were observed to have dark-brown urine at an early stage of their illness. Subsequently, acute anuric renal failure and hepatic dysfunction developed in all three. p-Aminophenol was identified by chromatographic and colorimetric methods in the urine of each case and is thought to be responsible for the discoloration.
D000082:Acetaminophen / Q000506:poisoning*; D058186:Acute Kidney Injury / Q000139:chemically induced; D000328:Adult; D000627:Aminophenols / Q000652:urine; D056486:Chemical and Drug Induced Liver Injury; D002855:Chromatography, Thin Layer; D003124:Colorimetry; D006801:Humans; D008297:Male; D008875:Middle Aged; D010860:Pigments, Biological / Q000652:urine*; D013997:Time Factors
D000627:Aminophenols; D010860:Pigments, Biological; D000082:Acetaminophen; C026729:4-aminophenol