Plasma bupivacaine concentrations following lumbar epidural anaesthesia in children.
Plasma levels of bupivacaine were measured following lumbar epidural administration of 3 mg/kg of 0.5% plain solution in sixteen children. The peak levels were generally between 1.0 and 2 micrograms/ml, the highest being 2.9 micrograms/ml. No manifestations of toxicity were observed. There was a significant positive correlation between peak plasma levels and increasing age.
D000375:Aging; D000767:Anesthesia, Epidural; D002045:Bupivacaine / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D006801:Humans
D002045:Bupivacaine