Chlorpromazine-sensitized photooxidation of squalene.
In connection with chlorpromazine-induced skin photosensitivity, chlorpromazine-sensitized photooxidation of squalene was studied in vitro. When squalene (in ethanolic solution or in an aqueous suspension) was irradiated with UV-A light in the presence of chlorpromazine, the yield of peroxidation products was greatly increased. Lines of evidence for the peroxidation were obtained by the iodometric determination and the thiobarbituric-acid method. Gas chromatography indicated that squalene was decomposed by the photosensitized reaction and the remaining amount was decreased exponentially with increasing fluence. The quenching effects of NaN3 and 2,5-dimethylfuran and the enhancing effect of D2O showed participation of singlet oxygen in the photosensitized reaction.
D002746:Chlorpromazine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D010777:Photochemistry; D010787:Photosensitivity Disorders / Q000209:etiology / Q000378:metabolism; D026082:Singlet Oxygen; D013185:Squalene / Q000528:radiation effects*; D014466:Ultraviolet Rays
D026082:Singlet Oxygen; D013185:Squalene; D010100:Oxygen; D002746:Chlorpromazine