Inner ear damage induced by Mycobacterium fortuitum.
We used electron microscopy to investigate Mycobacterium fortuitum-induced changes in the inner ears of mice. We found that the inner and outer hair cells had degenerated and disappeared in the organ of Corti. Changes in the lower turn of the cochlea were more severe than those of the upper turn while the changes of the outer hair cells were more severe than those of the inner hair cells. Disappearance, fusion and ballooning of the sensory hairs were observed in the vestibular organs. The bacterial extract also induced inner ear damage which was similar to that caused by live M. fortuitum.
D000818:Animals; D003051:Cochlea / Q000473:pathology; D007758:Ear, Inner / Q000473:pathology*; D006198:Hair Cells, Auditory / Q000473:pathology; D006199:Hair Cells, Auditory, Inner / Q000473:pathology; D007759:Labyrinth Diseases / Q000209:etiology*; D007762:Labyrinthitis / Q000209:etiology* / Q000473:pathology; D051379:Mice; D008808:Mice, Inbred CBA; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009164:Mycobacterium Infections / Q000473:pathology*; D009165:Mycobacterium Infections, Nontuberculous / Q000473:pathology*; D009925:Organ of Corti / Q000473:pathology