title: [Biotransformation of alimemazine].
abstract: After application of alimemazine (1) 14 phenothiazine derivatives were detected in the rat urine. The structure of 9 metabolites was elucidated (TLC detection, UV, MS), which are hydroxy, N-dealkyl, S-oxide, and sulfone derivatives of 1. The hydroxy compounds, which are the main metabolites (greater than 50%), are partly conjugated. 5-10% of sulfones were observed. Some of the metabolites were detected in the feces, too. The relationship of the excretion products in urine and feces is 75:25%.
mesh_terms: D000818:Animals; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D014291:Trimeprazine / Q000378:metabolism* / Q000652:urine
chemical_list: D014291:Trimeprazine
vernacular_title: Biotransformation von Alimemazin.