title: [The incidence of the disappearance of dehydrogenase activity in the myocardium in craniocerebral injuries].
abstract: In investigations of complications of craniocerebral injuries in casualties with a different period of survival, subjected to necropsy in the Institute for Forensic Medicine Medical Faculty, Charles University Prague the authors recorded the incidence of early ischemic and hypoxic lesions of the heart muscle. The dehydrogenase activity in the heart muscle was assessed by macroreaction with tetrazolium blue on Sikl slices. The myocardium was subjected to a detailed histological examination. The degree of atherosclerosis was assessed according to WHO guidelines. Thus 40 victims with a varying survival period were examined. In 16 of them usually major defects of dehydrogenase activity were found, in particular in the left ventricle and interventricular septum. Microscopic changes of muscle cells were relatively rare. This finding was very frequent also in the junior population without advanced coronary atherosclerosis. The above findings are important for the detailed assessment of pathomorphological changes which develop in conjunction with the injury and contribute towards the accurate assessment of the immediate cause of death.
mesh_terms: D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism*
chemical_list: D010088:Oxidoreductases
vernacular_title: K výskytu vymizení aktivity dehydrogenáz v myokardu u kraniocerebrálních traumat.