title: Hepatic dearterialization in cancer: new perspectives.
abstract: Attempts have been made over the last 20 years, without notable success, to improve the prognosis of hepatic tumors by interfering with the blood supply from the hepatic artery. We review the background and history of this technique and offer a hypothesis as to its mechanism via free radicals. The ways in which this modality of treatment could be improved to optimize damage to the tumour are outlined.
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D010478:Chemotherapy, Cancer, Regional Perfusion; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage; D005609:Free Radicals; D006499:Hepatic Artery / Q000601:surgery*; D006801:Humans; D000860:Hypoxia; D007511:Ischemia; D008026:Ligation; D008113:Liver Neoplasms / Q000098:blood supply / Q000601:surgery*
chemical_list: D000970:Antineoplastic Agents; D005609:Free Radicals; D005472:Fluorouracil