Diphenylhydantoin-induced lymphocytic interstitial pneumonia.
A patient developed diffuse lymphocytic interstitial pneumonia after receiving diphenylhydantoin therapy for 14 months. Withdrawal of medication resulted in reversal of the disease process. This case illustrates the value of combined transbronchial biopsy and bronchoalveolar lavage sampling in establishing a diagnosis, and the utility of serial bronchoalveolar lavage in monitoring disease evolution.
D000368:Aged; D001706:Biopsy; D001980:Bronchi / Q000473:pathology; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy; D005260:Female; D006801:Humans; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D011650:Pulmonary Alveoli / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000473:pathology; D007507:Therapeutic Irrigation
D010672:Phenytoin