[Changes in the filtration and reabsorption barrier of the kidneys of the rat after administration of nonsteroidal anti-inflammatory preparations].
Nonsteroid antiinflammatory preparations, influencing biosynthesis of renal prostaglandins, are able to produce certain changes in hemodynamics of the organ with successive ischemia. Administration of these preparation (indomethacin and voltaren) to rats in doses corresponding to human therapeutic ones, produces dystrophic changes in the canalicular epithelium of the nephron and appearance of infiltrates in the interstitium and in the lamina propria of the renal calyxes mucous membrane. Intercellular edema and changes in configuration of the cells, decreasing electron density of hyaloplasm, swelled mitochondria, diluted cysterns of the Golgi complex and of the endoplasmic reticulum--are general regularities in ultrastructural reorganization of the cells in response to administration of the two preparations. These changes differ only in degree of their manifestation. As demonstrate the results, the pharmacologic depression of the prostaglandin synthesis causes decreased blood supply of the kidneys and successive depression of their functional state. This can be considered as risk factors of the renal complications under treatment with the nonsteroid antiinflammatory preparations.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology*; D004848:Epithelium; D007213:Indomethacin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D007678:Kidney Glomerulus / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000187:drug effects; D008854:Microscopy, Electron; D008928:Mitochondria / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D004008:Diclofenac; D007213:Indomethacin
Izmeneniia fil'tratsionno-reabsorbtsionnogo bar'era pochek krys pri vvedenii nesteroidnykh protivovospalitel'nykh preparatov.