title: Experimental study on the comparative thrombolytic effects of intracoronary and intravenous administration of urokinase.
abstract: The effects of intracoronary (i.c.) and intravenous (i.v.) or intraventricular (i.vt.) urokinase (UK) administration were studied in a canine experimental model in which a coronary thrombus was produced by a modified electrical stimulation method. The success rate of coronary thrombolysis was 77% (17/22) with i.c. administration of 4,000 U/Kg of UK. Either i.v. or i.vt. UK administration of less than 24,000 U/Kg induced thrombolysis in 25% (2/8), while i.v. administration of more than 25,000 U/Kg resulted in a success rate of 64% (7/11) with a fibrinogen reduction from 313 +/- 63 mg/dl to 116 +/- 34 mg/dl.
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014568:Urokinase-Type Plasminogen Activator