Effect of alpha-chlorohydrin on the epididymis of the Indian palm squirrel (Funambulus pennanti).
The effects of alpha-chlorohydrin administration on the epididymis of the Indian palm squirrel were investigated. The drug induced dose-and duration related regressive histological changes in the three epididymal segments. In spite of the regressive changes in the epididymis, spermatogenesis continued uninterruptedly in alpha-chlorohydrin-treated animals. Treatment with the drug also induced alterations in the levels of epididymal nucleic acids, protein, sialic acid and glycogen. The alterations in the histology and chemical constituents of the epididymis in drug treated animals were completely reversible. Within 21 days after drug withdrawal, epididymal histology and constituents returned to the pre-treatment state.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002728:Chlorohydrins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004822:Epididymis / Q000187:drug effects*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects; D012589:Sciuridae; D012669:Seminal Vesicles / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects; D000517:alpha-Chlorohydrin / Q000494:pharmacology*
D002728:Chlorohydrins; D000517:alpha-Chlorohydrin