2,2'-Bipyridyl-6-carbothioamide derivatives as potential antitumor agents.
4- and/or 4'-substituted 2,2'-bipyridyl-6-carbothioamides have been synthesized and tested for their activity against P-388 lymphocytic leukemia in mice. Of these, only 4'-nitro-2,2'-bipyridyl-6-carbotioamide (IV c) proved to be active.
D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D011725:Pyridines / Q000138:chemical synthesis*
D000970:Antineoplastic Agents; D011725:Pyridines; D015082:2,2'-Dipyridyl