Evaluation of active specific immunization against paraquat toxicity in rats.
Four groups of Wistar rats were immunized against a BSA-paraquat derivative antigen, when lethally poisoned with paraquat dichloride via intraperitoneal route. No significant correlation in survival rate was observed between immunized (5/45) and control (0/26) rats, but a significant correlation (p less than 0.05) in the mean survival time was noted in immunized rats as compared to controls (9.1 +/- 16.8 days and 2.0 +/- 0.8 days versus 2.1 +/- 2.4 days and 1.0 +/- 0.1 days respectively).
D000818:Animals; D000917:Antibody Formation; D005260:Female; D007114:Immunization; D007116:Immunization, Passive; D008297:Male; D010269:Paraquat / Q000276:immunology / Q000506:poisoning*; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D013045:Species Specificity
D010269:Paraquat