title: Cytostatic activity of daunorubicin analogs containing daunosamine as furanoside.
abstract: This paper describes the synthesis of daunorubicin (daunomycin) analogs, differing from the natural antibiotics in the ring size of the sugar moiety (furanosides instead of pyranosides). Both, the 5-O-methyl derivative 7 as well as the daunosaminofuranoside 16 were less active cytostatics than doxorubicin (adriamycin), but 16 was also much less toxic, consequently its therapeutic index is more favourable.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D004317:Doxorubicin / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013055:Spectrophotometry, Infrared
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin; D003630:Daunorubicin