title: Pregnancy in Jamaican women with homozygous sickle cell disease. Fetal and maternal outcome.
abstract: The outcome of 664 pregnancies in 297 Jamaican women with homozygous sickle cell (SS) disease over the period 1959-1984 was reviewed. Overall, the spontaneous abortion rate was 118 per 1000 pregnancies, the stillbirth rate 128 per 1000 births, and perinatal mortality 171 per 1000 births. There was a striking secular increase in both spontaneous abortions and stillbirths which was accounted for, in part, by a trend for abortions to increase with maternal age up to the age of 30 years, a greater proportion of patients in the high-risk 25-29 year age group occurring in the 1980-1984 period. Another factor contributing to the poor obstetric performance in the 1980-1984 period was probably an increased survival and pregnancy rate in high-risk patients. Seven women had pregnancy-related deaths giving a pregnancy mortality rate of 1.1%.
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D005260:Female; D005313:Fetal Death; D006450:Hemoglobin SC Disease / Q000150:complications*; D006801:Humans; D007226:Infant Mortality; D007563:Jamaica; D008428:Maternal Mortality; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D011379:Prognosis