Differential response of amygdaloid neurons to clozapine and haloperidol: effects of repeated administration.
Rats were pretreated with saline or with behaviorally equivalent doses of clozapine (10.0 mg/kg) or haloperidol (1.0 mg/kg) twice daily for six consecutive days. On the following day, amygdaloid neurons in clozapine-pretreated rats responded to a challenge injection of this drug with a significantly greater increase in firing rate than saline controls. In contrast, amygdaloid neurons generally remained unresponsive to haloperidol even when pretreatment with this drug was extended to 13 days. Neither clozapine nor haloperidol pretreatment, however, altered the response of amygdaloid neurons to d-amphetamine administered after a four-day washout period. Amphetamine inhibited amygdaloid activity to a comparable extent in all rats. Taken together, these results implicate the amygdaloid complex as an important site of action of clozapine and related antischizophrenic drugs.
D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D003024:Clozapine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology; D003984:Dibenzazepines / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D003984:Dibenzazepines; D003024:Clozapine; D006220:Haloperidol; D003913:Dextroamphetamine