Nifedipine and flunarizine block amphetamine-induced behavioral stimulation in mice.
Sixteen calcium channel inhibitors (CCI's) were tested in a model utilizing amphetamine-induced behavioral stimulation in mice. Nifedipine, flunarizine and possibly PY 108-068 were effective in blocking amphetamine-induced locomotor stimulation. Verapamil, diltiazem and many other CCI's were ineffective in this experimental paradigm.
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002936:Cinnarizine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D005444:Flunarizine; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009543:Nifedipine / Q000031:analogs & derivatives / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D002936:Cinnarizine; D009543:Nifedipine; C034600:darodipine; D005444:Flunarizine; D003913:Dextroamphetamine