Changes in mouse intervertebral-disc proteoglycan synthesis with age. Hereditary kyphoscoliosis is associated with elevated synthesis.
Mice with hereditary kyphoscoliosis (ky/ky) develop intervertebral-disc degeneration at the cervico-thoracic junction. Disc proteoglycans were investigated to determine whether changes in synthesis or structure were associated with this. Elevated 35S-proteoglycan synthesis was found in one or more cervico-thoracic discs in 80-day-old ky/ky mice. The hydrodynamic size and aggregation properties of ky/ky-mouse disc 35S-proteoglycans extracted with 4 M-guanidinium chloride were normal. Increased proportions of small 35S-proteoglycans were extracted with 0.5 M-guanidinium chloride from discs of normal and ky/ky mice with increasing age.
D000367:Age Factors; D000818:Animals; D006025:Glycosaminoglycans / Q000096:biosynthesis; D007403:Intervertebral Disc / Q000378:metabolism*; D046911:Macromolecular Substances; D051379:Mice; D011509:Proteoglycans / Q000096:biosynthesis*; D012544:Scheuermann Disease / Q000378:metabolism*; D012995:Solubility
D006025:Glycosaminoglycans; D046911:Macromolecular Substances; D011509:Proteoglycans