[Activity of cholesterol metabolism enzymes and lipid levels in the rat liver, aorta, adrenals and serum after exposure to triton WR 1339].
Injection of Triton WR 1339 into Wistar rats caused a marked increase in contents of free and ester-bound cholesterol, triglycerides, phospholipids and free fatty acids in tissues and a decrease in the activity of lecithin: cholesterol acyltransferase in blood. An increase in concentration of cholesterol esters in tissues was due to a decrease in activity of lysosomal cholesteryl esterase in vivo and in vitro and to an increase in non-sedimentable activities of acid phosphatase, beta-galactosidase and cholesteryl esterase. The decrease in proteolytic degradation of cholesterol esters was accompanied by an increase in the activity of tissue cytoplasmic cholesteryl esterase and by a decrease in activity of acyl-CoA: cholesterol O-acyltransferase in liver tissue.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D002788:Cholesterol Esters / Q000097:blood / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D011092:Polyethylene Glycols / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D002787:Sterol Esterase / Q000378:metabolism; D002785:Sterol O-Acyltransferase / Q000378:metabolism
D002788:Cholesterol Esters; D008055:Lipids; D011092:Polyethylene Glycols; D002784:Cholesterol; D002785:Sterol O-Acyltransferase; D002787:Sterol Esterase; C016811:tyloxapol
Aktivnost' fermentov kholesterinovogo metabolizma i soderzhanie lipidov v pecheni, aorte, nadpochechnikakh i syvorotke krovi krysy pri vozdeĭstvii tritona WR 1339.