A differential effect of the Walker 256 carcinoma on the tyrosine protein kinase activity of liver plasma membrane domains.
Protein kinase activity was investigated in plasma membrane fractions enriched in either sinusoidal or lateral domains prepared from liver of normal rats and rats bearing a Walker 256 carcinoma. Membrane proteins were phosphorylated on tyrosine, threonine and serine residues in both fractions. Phosphorylation of tyrosine residues was increased in sinusoidal preparations from tumour-bearing rats but not in lateral preparations. An increase in histone phosphorylation by sinusoidal preparations from tumour-bearing rats was found to be due to serine protein kinase activity.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000201:enzymology*; D002462:Cell Membrane / Q000201:enzymology; D005260:Female; D008099:Liver / Q000201:enzymology*; D008565:Membrane Proteins / Q000378:metabolism; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D008565:Membrane Proteins; D011505:Protein-Tyrosine Kinases