title: Effect of spironolactone on acute mountain sickness.
abstract: This study examined the effectiveness of spironolactone as a prophylactic agent for the prevention of acute mountain sickness (AMS). Spironolactone, 25 mg PO QID, or placebo was administered to nine subjects in a double-blind, placebo-controlled, crossover design. Medication was given for 48 h prior to and during a 46-h exposure to 427 mm Hg (4570 m) in a hypobaric chamber. Six subjects demonstrated prevention of either the cerebral or respiratory symptoms of AMS during at least one segment of the altitude sojourn.
mesh_terms: D000208:Acute Disease; D000328:Adult; D004311:Double-Blind Method; D006801:Humans; D000860:Hypoxia / Q000517:prevention & control*; D008297:Male; D010919:Placebos; D011897:Random Allocation; D013148:Spironolactone / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D010919:Placebos; D013148:Spironolactone