[Changes in membrane proteins in the brain stem of the rat after deprivation of the paradoxical stage of sleep and prolongation of this stage during subsequent free behavior].
In REM-sleep-deprived rats, phenazepam (1.0 mg/kg) prevented the SH-group content increase in the brain stem membrane proteins, but induced undesirable sedative phenomena which, however, could be eliminated by simultaneous injections of sydnocarbum. The data obtained suggest that if the brain stem membrane proteins are protected against a denaturation-like alteration (characterized by the increase of SH-group content of these proteins) during REM-sleep deprivation, there is no "rebound" of this sleep phase after the end if the experiment in the condition of the unrestrained behavior of the rats.
D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D001933:Brain Stem / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D004347:Drug Interactions; D004569:Electroencephalography; D008565:Membrane Proteins / Q000032:analysis*; D009419:Nerve Tissue Proteins / Q000032:analysis*; D010069:Oxadiazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012892:Sleep Deprivation / Q000187:drug effects*; D012895:Sleep, REM / Q000502:physiology*; D013558:Sydnones / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D010069:Oxadiazoles; D013558:Sydnones; D001569:Benzodiazepines; C017928:phenazepam; C009257:sidnocarb
Izmeneniia membrannykh belkov v stvole golovnogo mozga krys pri lishenii ikh paradoksal'noĭ fazy sna i prodolzhitel'nost' étoĭ fazy pri posleduiushchem svobodnom povedenii.