title: Options in the management of perforations of the esophagus.
abstract: A study of 90 cases of esophageal perforation in the antibiotic era emphasizes individualized treatment and options of therapy based on a fundamental understanding of modifying pathophysiologic factors. If the patient is seen during the first 24 hours, surgical repair and irrigating tube drainage continue to be the treatment of choice in the thoracic and abdominal regions, with certain exceptions. The exceptions include small perforations proved by a thin media esophagram or esophagoscopy without pleural involvement or constitutional symptoms. Such patients may be treated nonoperatively, with gastric drainage, antibiotics, and parenteral alimentation. However, for large perforations with extensive contamination of the mediastinum and pleura, an esophageal exclusion operation may be life saving. In the cervical region, irrigating tube drainage may be just as effectual as repair and drainage. In patients seen after 24 hours, size of the perforation and the amount of mediastinopleural infection, rather than the time that has elapsed, dictate optimal treatment.
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D004322:Drainage; D004939:Esophageal Perforation / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D004947:Esophagus / Q000293:injuries / Q000473:pathology / Q000601:surgery*; D005547:Foreign Bodies / Q000150:complications; D006801:Humans; D007440:Intubation / Q000009:adverse effects; D011183:Postoperative Complications; D013524:Surgical Flaps
chemical_list: D000900:Anti-Bacterial Agents