Evaluation of anti-cardiolipin antibody and its cross-reactivity in sera of patients with lepromatous leprosy.
Using a sensitive and modified solid-phase radioimmunoassay for detecting anti-cardiolipin antibodies, sera of 45 patients with lepromatous leprosy were examined. Nine of the 45 (20%) showed positive levels of anti-cardiolipin antibodies. Inhibition tests revealed that these antibodies significantly cross-reacted with double-stranded (ds) DNA, but not with single-stranded (ss) DNA or extractable nuclear antigens (ENA). We describe the unique pattern of antibody cross-reactivity with cardiolipin and dsDNA in sera of patients with lepromatous leprosy.
D034961:Antigens, Nuclear; D001323:Autoantibodies / Q000276:immunology*; D002308:Cardiolipins / Q000276:immunology*; D003429:Cross Reactions; D004247:DNA / Q000276:immunology; D004277:DNA, Single-Stranded / Q000276:immunology; D006801:Humans; D007918:Leprosy / Q000276:immunology*; D009698:Nucleoproteins / Q000276:immunology
D034961:Antigens, Nuclear; D001323:Autoantibodies; D002308:Cardiolipins; D004277:DNA, Single-Stranded; D009698:Nucleoproteins; D004247:DNA