On the physiological role of neurocuprein: aponeurocuprein is an inhibitor of dopamine beta-monooxygenase.
The apoform of neurocuprein, the copper protein from brain and chromaffin granules, was found to be a potent inhibitor of the hydroxylating activity of dopamine beta-monooxygenase, whereas the holoform of neurocuprein has no effect on the activity of the enzyme. The inhibiting capacity of neurocuprein may be due to the property of the apoprotein to chelate copper from the enzyme. A role of neurocuprein as an endogenous protein regulator of dopamine beta-monooxygenase is suggested.
D000818:Animals; D001059:Apoproteins / Q000494:pharmacology*; D001923:Brain Chemistry; D002396:Catechols / Q000378:metabolism; D002417:Cattle; D002837:Chromaffin Granules / Q000032:analysis; D003300:Copper / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D008667:Metalloproteins / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D013329:Structure-Activity Relationship; D014439:Tyramine / Q000378:metabolism
D001059:Apoproteins; D002396:Catechols; D008667:Metalloproteins; C049745:aponeurocuprein; C018612:neurocuprein; D003300:Copper; D004299:Dopamine beta-Hydroxylase; C034221:catechol; D014439:Tyramine