[Autonomic innervation of the heart of young patients with insulin-dependent diabetes].
The autonomic innervation of the heart has been studied in 32 young patients with insulin-dependent diabetes mellitus and 28 controls by measuring the intervals PP of electrocardiograms at rest, deep breathing, stimulation of n. vagus according to Ashner method and after suppression of vagus tone by atropine. The orthostatic test was performed. The patients with diabetes were established to have a higher heart rate and less manifested variations of the intervals PP at rest. During deep breathing, the patients with diabetes also showed a poorer variability of the intervals PP as compared with the controls. The reactions, however, in both groups with Ashner test and orthostatic test, were similar. Asymptomatic sinoatrial block was recorded in a patient with diabetes by the method of Ashner. The study revealed that the autonomic innervation of the heart was oft disturbed in case of diabetes. There was a correlation between the severity of that disorder and diabetes duration, diabetic peripheral polyneuropathy established in all cases. The other manifestations of diabetic polyneuropathy are more rare and later observed. The disturbed autonomic innervation of heart activity could be responsible, in some cases, for the sudden cardiac death among the patients with diabetes.
D000293:Adolescent; D000328:Adult; D001285:Atropine; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects / Q000294:innervation* / Q000503:physiopathology; D006801:Humans; D008297:Male; D013997:Time Factors; D014630:Vagus Nerve / Q000502:physiology
D001285:Atropine
Prouchvaniia vŭrkhu vegetativnata inervatsiia na sŭrtseto u mladi bolni s insulinozavisim diabet.