title: Adrenocortical adenoma with Cushing's syndrome. Scanning electron microscopic observations.
abstract: Adrenocortical adenomas with Cushing's syndrome (Cushing's adenoma) consisted of two different features, which intermingled in various proportions and were related with each other. The first feature showed long-columnar or trabecular arrangement and a vacuolar appearance which correspond to lipid droplets of clear-type cells. In the second feature, the sinusoid was well developed and meandering, and the perisinusoidal space was prominent and contained collagen fibrils, bleb-like structures, and granules. The collagen fibrils were entangled with the parenchymal cells. The sinusoid was lined by a sinusoidal wall with fenestrations or pores. Bleb-like structures and granules traversed them. Two different features were speculated to be consistent with areas of clear-type cells and compact-type cells, respectively, observed light and transmission electron microscopies.
mesh_terms: D000236:Adenoma / Q000150:complications / Q000473:pathology / Q000648:ultrastructure*; D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000473:pathology / Q000648:ultrastructure*; D003094:Collagen / Q000032:analysis; D003480:Cushing Syndrome / Q000150:complications / Q000473:pathology*; D006801:Humans; D008855:Microscopy, Electron, Scanning / Q000379:methods*
chemical_list: D003094:Collagen