Poly(iminocarbonates) as potential biomaterials.
Poly(iminocarbonates), based on diphenols such as hydroquinone or Bisphenol A were synthesized. Poly(iminocarbonates) degraded under physiological conditions. Compression moulded discs of poly-(hydroquinone-iminocarbonate) showed near zero-order release for low loadings (1%, w/w) of Eosin Y. Poly(Bisphenol A-iminocarbonate) formed transparent films and strong fibres. It is a tough polymer with high tensile strength. Under physiological conditions complete erosion of a thin film of poly(Bisphenol A-iminocarbonate) required about 200 d. The release profile for p-nitroaniline from solvent cast films of poly(Bisphenol A-iminocarbonate) was characterized by a lag period (20 d), followed by near zero-order release for 90 d. Initial toxicological studies revealed no inflammatory cell response after implantation in the corneas of rabbits or subcutaneously in mice.
D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D002254:Carbonates / Q000633:toxicity; D003238:Connective Tissue / Q000187:drug effects; D003315:Cornea / Q000187:drug effects; D006868:Hydrolysis; D007097:Imines / Q000633:toxicity; D008297:Male; D051379:Mice; D008970:Molecular Weight; D011108:Polymers / Q000633:toxicity; D019736:Prostheses and Implants; D011817:Rabbits; D013718:Tensile Strength
D001672:Biocompatible Materials; D002254:Carbonates; D007097:Imines; D011108:Polymers