[Intrarenal calcium crystallization. An electron microscopy study].
Male Wistar rats were treated by ethylene glycol (0.8 Vol% in water) or a diet low in magnesium (70 mg/kg). The intrarenal crystallisation and stone formation of calcium oxalate was investigated by SEM, TEM and energy dispersive X ray analysis. The first stage in crystallisation was amorphous deposits of calcium surrounding microvilli of the lower part of the nephron, followed by multicentric, intratubular calcium crystals. Finally calcium plaques of the papilla seemed to be precursors of the urinary stone.
D000818:Animals; D002129:Calcium Oxalate / Q000378:metabolism*; D003460:Crystallization; D004195:Disease Models, Animal; D007669:Kidney Calculi / Q000473:pathology*; D007679:Kidney Medulla / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology; D008854:Microscopy, Electron; D008871:Microvilli / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D002129:Calcium Oxalate
Die intrarenale Kalzium-Kristallisation. Eine elektronenmikroskopische Untersuchung.