beta-phenylethylamine effect on brain and blood catechol-O-methyltransferase activity.
A significant decrease in catechol-o-methyltransferase (COMT) activity has been found in the striatum (77% of control) and hippocampus (63% of control) of gerbils treated with daily injections of beta-phenylethylamine (50 mg/kg) for 10 days. This treatment group also exhibited increased (204% above control) COMT activity in a lysed red blood cell preparation. There were no changes in COMT activity in groups receiving 10 mg/kg beta-phenylethylamine or haloperidol (0.5 mg/kg). In vitro beta-phenylethylamine has no demonstrable effect on COMT activity.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D001933:Brain Stem / Q000201:enzymology; D002394:Catechol O-Methyltransferase / Q000097:blood / Q000378:metabolism*; D002540:Cerebral Cortex / Q000201:enzymology; D003342:Corpus Striatum / Q000201:enzymology; D005849:Gerbillinae; D006624:Hippocampus / Q000201:enzymology; D007031:Hypothalamus / Q000201:enzymology; D008032:Limbic System / Q000201:enzymology; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology*
D010627:Phenethylamines; C029261:phenethylamine; D002394:Catechol O-Methyltransferase