Absorption of controlled release morphine sulphate in the immediate postoperative period.
The absorption of morphine sulphate, given orally as a controlled release preparation, was studied in 10 patients who had undergone peripheral vascular surgery with a standard opioid-based general anaesthetic technique. Serum morphine concentrations were measured (high pressure liquid chromatography) every 2 h for the first 16 h after surgery and the results were strongly suggestive of a decrease in the rate of absorption of morphine in this situation.
D000284:Administration, Oral; D000368:Aged; D003692:Delayed-Action Preparations; D006801:Humans; D007408:Intestinal Absorption; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*
D003692:Delayed-Action Preparations; D009020:Morphine