[Retinoids and lipid metabolism].
Since systemic administration of synthetic retinoids was introduced into dermatology and oncology, side-effects of synthetic vitamin-A derivatives on lipid and lipoprotein metabolism have become apparent. Retinoids of the first and second generation, 13-cis-retinoic acid and etretinate, are capable of inducing secondary hyperlipoproteinemias. For further evaluation of the atherogenic risk of retinoid-induced hyperlipoproteinemias, the most relevant effects of natural and synthetic retinoids on lipid metabolism as well as the interactions between lipid and retinoid metabolism are considered in this review.
D001161:Arteriosclerosis / Q000139:chemically induced; D001711:Biotransformation; D002784:Cholesterol / Q000097:blood; D002914:Chylomicrons / Q000097:blood; D005050:Etretinate / Q000009:adverse effects; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000139:chemically induced*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D012176:Retinoids / Q000009:adverse effects* / Q000097:blood; D012177:Retinol-Binding Proteins / Q000378:metabolism; D014212:Tretinoin / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood; D014801:Vitamin A / Q000009:adverse effects / Q000097:blood
D002914:Chylomicrons; D008055:Lipids; D008074:Lipoproteins; D012176:Retinoids; D012177:Retinol-Binding Proteins; D014280:Triglycerides; D014801:Vitamin A; D014212:Tretinoin; D005050:Etretinate; D002784:Cholesterol
Retinoide und Lipidstoffwechsel.