Trypsin-binding immunoglobulin G in cystic fibrosis, allergic, and normal children.
Using a simple and sensitive radioassay, we have determined the frequency of trypsin-binding (TB) immunoglobulin G (IgG) as a function of age in cystic fibrosis (CF) patients, in allergic patients, and in control subjects. These IgGs appear during the 1st years of life. Their frequency is maximum between 3 and 20 years of age and decreases during adulthood. In allergic children TBIgG appears later than in CF children and the maximum frequency (32%) is intermediate between those observed in CF and in control children (66 and 19.6%, respectively). We suggest that an endogenous form of trypsin is involved in the phenomenon.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000097:blood* / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism*; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D011485:Protein Binding; D014357:Trypsin / Q000378:metabolism*
D007074:Immunoglobulin G; D014357:Trypsin