Osmotic threshold for vasopressin release in hyperprolactinemic patients.
Eleven patients with chronic hyperprolactinemia were tested to determine their osmotic threshold by isovolemic infusion of 5% NaCl. The results obtained demonstrate no statistical difference from known values in healthy volunteers. No linear correlation was found between levels of blood prolactin and the osmotic threshold, except for 1 patient who represents downward resetting of the hypothalamic osmoreceptors. The average time elapsed from the maximal dilution point to the osmotic threshold in hyperprolactinemia was found to be significantly shorter than in the normal population. We conclude that prolactin does not appear to participate in the osmotic regulation in man.
D000293:Adolescent; D000328:Adult; D001971:Bromocriptine / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000503:physiopathology*; D007263:Infusions, Parenteral; D008297:Male; D011388:Prolactin / Q000097:blood / Q000502:physiology; D012965:Sodium Chloride / Q000008:administration & dosage; D014667:Vasopressins / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D014667:Vasopressins; D001971:Bromocriptine; D012965:Sodium Chloride; D011388:Prolactin