Long-term follow-up of dermatitis herpetiformis in children.
Dermatitis herpetiformis was diagnosed in seventy-six children by its clinical features and by detection of granular IgA deposits in the papillary dermis of perilesional skin. Enteric alterations demonstrated by measurement of D-xylose absorption and by small intestinal biopsies were detected in over 90% of all patients. A complete follow-up was obtained for all children who were followed for 3 to 10 years. Treatment with a gluten-free diet alone led to a reversal of the intestinal abnormality in 100% of our children and to the disappearance of cutaneous lesions in 82% of reported cases. This suggests that a complete remission of symptoms can be obtained with a gluten-free diet alone. Dapsone alone is effective therapy for the rash but does not affect the intestinal alterations. Furthermore, the lack of side effects to dietetic therapy for a long period of time makes the diet the treatment of choice in this disease.
D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003622:Dapsone / Q000009:adverse effects / Q000627:therapeutic use; D003874:Dermatitis Herpetiformis / Q000178:diet therapy / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005983:Glutens; D006801:Humans; D007583:Jejunum / Q000473:pathology; D008297:Male; D012008:Recurrence
D005983:Glutens; D003622:Dapsone