Quinolones affect thymidine incorporation into the DNA of human lymphocytes.
The incorporation of [3H]thymidine into DNA was increased in phytohemagglutinin-stimulated human lymphocytes exposed to four of the new quinolone derivatives (ciprofloxacin, norfloxacin, ofloxacin, and A 56620) at concentrations achievable in clinical situations. However, proliferation of phytohemagglutinin-stimulated lymphocytes was not influenced by ciprofloxacin at concentrations of 0.5 to 10 micrograms/ml.
D004247:DNA / Q000096:biosynthesis*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism*
D010835:Phytohemagglutinins; D011804:Quinolines; D004247:DNA; D013936:Thymidine