title: Calcium entry blocking activity of adenosine potentiating compounds in guinea pig taenia coli.
abstract: Calcium entry blocking activities of adenosine and its potentiating drugs, dilazep, lidoflazine and dipyridamole, were studied in potassium (100 mM)-depolarized guinea pig taenia coli, and compared with nifedipine, verapamil and diltiazem. The potency ratio of calcium entry blocking effect of nifedipine, diltiazem, lidoflazine and dilazep to verapamil was 158.5, 1/1.1, 1/15.8 and 1/81.3, respectively. Dipyridamole and adenosine had negligible calcium entry blocking effects.
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects; D004109:Dilazep / Q000494:pharmacology; D004110:Diltiazem / Q000494:pharmacology; D004176:Dipyridamole / Q000494:pharmacology; D004357:Drug Synergism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008013:Lidoflazine / Q000494:pharmacology; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D009543:Nifedipine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
chemical_list: D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D004176:Dipyridamole; D014700:Verapamil; D004110:Diltiazem; D004109:Dilazep; D009543:Nifedipine; D008013:Lidoflazine; D000241:Adenosine; D011188:Potassium