title: A completely automatic method of processing 131I-labelled Rose Bengal dynamic liver studies.
abstract: A completely automatic method of measuring Rose Bengal uptake by the liver, expressed in terms of the half-time T1/2, is described. There is no requirement to construct time-activity curves with blood background activity correction as in the conventional regions-of-interest method. All the dixels in the image of a study are used in the actual data analysis. The method is therefore independent of operator influence. The intersection method is offered as an alternative to the manual method. The intersection method uses principal components analysis as a first step in the computation of the intersection of a theory space and a study space. A simple exponential function is used to generate the liver theory space. Sixty 131I Rose Bengal liver function studies were processed by the intersection method. The first forty minutes of patient data were used in the analysis. To validate the new method, computed T1/2 values were compared with those obtained by the manual method. A standard statistical test showed no significant difference between the two methods. Regression analysis gave a value for the coefficient of correlation of 0.89. The intersection method is currently in routine use for the automatic analysis of Rose Bengal liver studies and is faster than the manual method.
mesh_terms: D001322:Autoanalysis; D006801:Humans; D007457:Iodine Radioisotopes; D007700:Kinetics; D008099:Liver / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D012395:Rose Bengal; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes; D012395:Rose Bengal