Multipup homing: a rapid test for olfactory discrimination in neonatal rats.
The multipup homing procedure (MHP) is a rapid test for olfactory discrimination performance that can be run on an entire 8-pup litter of neonatal rats in 8 min. Performance improved developmentally with age, and females tended to perform better than males. The MHP was examined for its usefulness in detecting early postnatal effects of low-level prenatal exposure to chlorpromazine (CPZ) or d-amphetamine (AMPH). CPZ increased response latencies in both males and females, but AMPH had no significant effects. The MHP appears promising for use in behavioral teratological assessment of neurobehavioral function.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001522:Behavior, Animal / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D004192:Discrimination, Psychological / Q000187:drug effects; D005260:Female; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012737:Sex Factors; D012903:Smell / Q000187:drug effects*
D003913:Dextroamphetamine; D002746:Chlorpromazine