The acute thrombogenicity of a compliant polyurethane arterial graft compared with autologous vein. An experimental study in sheep.
The acute thrombogenicity of a new type of polyurethane urea graft was compared with that of autologous femoral vein graft in a sheep carotid artery interposition model. There was significantly more thrombus formation (as measured from thrombus weight and thrombus-free surface) and greater platelet accumulation in the polyurethane graft. Despite flow restriction to 25 ml/min, the patency rates after 4 hours were similar; all veins were patent and only one of the eight polyurethane grafts was occluded.
D000818:Animals; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D002339:Carotid Arteries / Q000601:surgery; D005260:Female; D005268:Femoral Vein / Q000637:transplantation*; D008297:Male; D010976:Platelet Count; D011140:Polyurethanes; D011183:Postoperative Complications / Q000209:etiology*; D012756:Sheep; D013927:Thrombosis / Q000209:etiology*
D001672:Biocompatible Materials; D011140:Polyurethanes