Langerhans cells are not damaged in contact allergic reactions in humans.
Fifteen biopsies from contact allergic reactions in sensitized patients were taken at different time intervals after application of simple chemicals. Two different procedures for electron microscopy were done. No signs of damage were ever seen in Langerhans cells. The authors are therefore of the opinion that there is still no proof for a target role of Langerhans cells in contact allergic reactions in humans.
D003035:Cobalt / Q000009:adverse effects; D003877:Dermatitis, Contact / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007801:Langerhans Cells / Q000187:drug effects / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009532:Nickel / Q000009:adverse effects; D011192:Potassium Dichromate / Q000009:adverse effects
D003035:Cobalt; C029938:nickel sulfate; D009532:Nickel; C026305:cobalt sulfate; D011192:Potassium Dichromate