Facilitation of olfactory bulb kindling after specific destruction of serotoninergic terminals in the olfactory bulb of the rat.
The role of serotonin (5-HT) in the kindling model of epilepsy was investigated by performing specific lesions of the 5-HT innervation at the level of the primary epileptogenic focus. We injected bilaterally 5,6-dihydroxytryptamine in the olfactory bulb (OB) of adult rats which were submitted to electrical stimulations of the OB until the occurrence of stage-5 seizures. Immunohistochemical controls of lesions were realized with a specific anti-5-HT antibody. Results revealed that the lesions facilitated the initial development of kindling (increase of afterdischarge duration and of kindling rate), suggesting that 5-HT terminals exert a modulatory effect on the propagation of the epileptic activity.
D000818:Animals; D004558:Electric Stimulation; D004597:Electroshock; D006892:Hydroxydopamines / Q000494:pharmacology; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D009410:Nerve Degeneration; D009411:Nerve Endings / Q000187:drug effects / Q000502:physiology*; D009830:Olfactory Bulb / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D012640:Seizures / Q000503:physiopathology; D012701:Serotonin / Q000502:physiology*
D006892:Hydroxydopamines; D012701:Serotonin