[Monoamine oxidase activity and effect of clorgyline on the polyamine level during hyperoxia in rats].
During hyperoxia monoamine oxidase type A acquires the ability to deaminate polyamines and histamine. A preliminary injection of clorgyline (a monoamine oxidase type A inhibitor) before hyperoxic exposure leads to a significant removal of oxygen seizures and prevents changes in the cerebral spermidine and histamine content observed in the unprotected animals. The data confirm the important role of modification of catalytic properties in monoamine oxidase in the mechanism of oxygen intoxication.
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D003010:Clorgyline / Q000494:pharmacology*; D003641:Deamination; D005260:Female; D006632:Histamine / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism*; D010100:Oxygen / Q000633:toxicity*; D011073:Polyamines / Q000378:metabolism*; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D013379:Substrate Specificity
D011073:Polyamines; D011437:Propylamines; D006632:Histamine; D008995:Monoamine Oxidase; D003010:Clorgyline; D010100:Oxygen
Monoaminoksidaznaia aktivnost' i vliianie khlorgilina na uroven' poliaminov pri giperoksii u krys.