Dose-dependent bioavailability of propranolol.
The pharmacokinetics of orally administered propranolol in doses of 10, 40, 80 and 160 mg was studied in eight healthy volunteers in a cross-over trial. The analytical method applied made possible a parallel determination of propranolol and of 4-OH propranolol. The dose-dependent kinetics of orally administered propranolol was demonstrated. In our study linear dependence could be established only within a dosage range of 40 mg to 160 mg. Both substances determined in plasma, propranolol as well as 4-OH propranolol, show a tendency toward non-linearity, particularly at the lower dosage range between 10 and 40 mg.
D000328:Adult; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D011433:Propranolol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood*
C001422:4-hydroxypropranolol; D011433:Propranolol