Are serum levels and cardiac effects of digoxin influenced by indometacin?
Intraindividually compared to placebo, the possible influence of an oral pretreatment with the cyclooxygenase inhibitor indometacin on serum concentrations and cardiac effects of digoxin, administered by a controlled intravenous infusion, was evaluated in 6 healthy male humans. A significant pharmacokinetic or pharmacodynamic interaction between both drugs could not be found. Indometacin only tended to elevate serum digoxin levels, to strengthen the digoxin induced decrease in the electrocardiogram parameters heart rate and QTc time as well as to reduce the positive inotropic action of digoxin measured by systolic time intervals and PTQ index.
D000328:Adult; D003404:Creatinine / Q000097:blood; D004077:Digoxin / Q000097:blood / Q000494:pharmacology*; D004347:Drug Interactions; D004562:Electrocardiography; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007700:Kinetics; D008297:Male
D004077:Digoxin; D003404:Creatinine; D007213:Indomethacin