Effects of therapeutic ultrasound on the activity of the mononuclear phagocyte system in vivo.
Therapeutic intensities of continuous wave ultrasound applied over the umbilical area of female rats resulted in a decrease in the rate of removal of 99mtechnetium radio-labelled sulphur colloid by the mononuclear phagocyte system. The magnitude of this effect increased both with increasing intensity of ultrasound and with the duration of exposure, and was found to be dependent upon the total amount of energy deposited within the umbilical area. This effect appeared to be initiated by an effect of ultrasound upon circulating lymphocytes since isolated lymphocytes sonicated in vitro at therapeutic intensities and then injected intravenously resulted in a decrease in the rate of colloid removal in vivo similar to that observed when the umbilical area had been sonicated in vivo. The mechanism by which this is thought to occur is discussed.
D000818:Animals; D003102:Colloids; D005260:Female; D066298:In Vitro Techniques; D007700:Kinetics; D009000:Monocytes / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D013455:Sulfur / Q000097:blood; D014343:Trypan Blue; D014464:Ultrasonic Therapy
D003102:Colloids; D013455:Sulfur; D014343:Trypan Blue