Induction of a cytotoxin from murine macrophages by an animal lectin.
Vertebrate lectin purified from loach eggs stimulated release of cytotoxin from BCG-or glucan (TAK)-elicited peritoneal macrophages and a murine macrophage cell line (J774.1), but not from resident peritoneal cells. The cytotoxin released from J774.1 cells on stimulation with loach egg lectin was a heat-labile protein with a molecular weight of about 55K.
D000818:Animals; D002460:Cell Line; D003603:Cytotoxins / Q000096:biosynthesis*; D006358:Hot Temperature; D037102:Lectins / Q000494:pharmacology*; D008262:Macrophage Activation; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008970:Molecular Weight
D003603:Cytotoxins; D037102:Lectins