Cytogenetic analysis and muscle differentiation in a girl with severe muscular dystrophy.
The uncommon case is described of a girl severely affected with Duchenne muscular dystrophy. Cytogenetic analysis revealed no numerical or structural abnormalities of the X-chromosome in any of the cells examined (leucocytes and myoblasts). No abnormality in morphology, growth pattern or differentiation was observed in the dystrophic muscle cultures as compared with control cultures.
D002454:Cell Differentiation; D002478:Cells, Cultured; D002675:Child, Preschool; D002871:Chromosome Banding; D005260:Female; D006801:Humans; D007621:Karyotyping; D009132:Muscles / Q000473:pathology*; D009136:Muscular Dystrophies / Q000235:genetics* / Q000473:pathology; D013577:Syndrome