[Antenatal prevention, using lithium oxybutyrate, of changes in the development of the rat brain caused by serum from schizophrenic patients].
It has been found that antenatal administration of schizophrenic patients' sera to rats has neuroembryotoxic effect on their progeny, decreasing the number of females in the brood, disturbing motor coordination and space perception in young male rats, slightly stimulating muscular force and motor activity, altering lateralization of the behaviour. Antenatal lithium hydroxybutyrate was shown to prevent some of the serum effects.
D000328:Adult; D000368:Aged; D000818:Animals; D001790:Blood Physiological Phenomena; D001921:Brain / Q000196:embryology*; D005260:Female; D006801:Humans; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D008094:Lithium / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D011247:Pregnancy; D051381:Rats; D012563:Schizophrenia, Paranoid / Q000097:blood*
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; C022826:lithium hydroxybutyrate; D008094:Lithium
Antenatal'naia profilaktika oksibutiratom litiia nekotorykh izmeneniĭ v razvitii mozga krys, vyzyvaemykh syvorotkoĭ bol'nykh shizofrenieĭ.