title: Cleaning up pertussis vaccine.
abstract: The side effects regularly observed with standard pertussis vaccine are thought to be due to its endotoxin content. Using polymyxin-Sepharose affinity chromatography the endotoxin content of the vaccine can be reduced 1000-fold. Assays are currently in progress to test the protective effect of the purified vaccine.
mesh_terms: D002846:Chromatography, Affinity; D004731:Endotoxins; D006801:Humans; D010567:Pertussis Vaccine / Q000302:isolation & purification
chemical_list: D004731:Endotoxins; D010567:Pertussis Vaccine