title: [Need for blood level-oriented therapy with antiepileptic drugs in pregnancy].
abstract: Determinations of antiepileptic drug blood level for therapy monitoring have been carried out in combined obstetric-neurologic prenatal care of epileptic pregnant women. In our opinion this blood level oriented dosage necessary in high risk patients for seeing in time if and in which scale serum level may drop during pregnancy, to change dosage or eventually to change drug in cases with increasing frequency or severity of convulsions. This method allows especially to control intake or to diagnose a pharmacophobia during gestational period.
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000097:blood / Q000627:therapeutic use*; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011485:Protein Binding
chemical_list: D000927:Anticonvulsants
vernacular_title: Zur Notwendigkeit der blutspiegelorientierten Therapie mit Antiepileptika während der Schwangerschaft.