[Meningococcal meningitis in isolated familial deficiency of the 7th complement component, C7].
Based on recent reports of a hereditary disposition to neisserial infections in subjects deficient in one of the hemolytic components of the complement system, we have studied 2 siblings who had had "sporadic" meningococcal meningitis in 1976 and 1977 respectively. In neither was C7 detectable, which suggested a homozygous deficiency. The two children of the first propositus showed values compatible with a heterozygous state.
D000328:Adult; D003184:Complement C7 / Q000172:deficiency*; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics* / Q000276:immunology; D008297:Male; D008585:Meningitis, Meningococcal / Q000235:genetics* / Q000276:immunology; D010375:Pedigree; D012306:Risk
D003184:Complement C7
Meningokokken-Meningitis bei isoliertem familiären Mangel der 7. Komplementkomponente, C7.