The effect of oral digoxin on sodium excretion, renin-angiotensin-aldosterone system and blood pressure in normotensive subjects.
The effect of digoxin (0.25 mg t.d.s.) given orally for 5 days, on sodium excretion, plasma renin activity, plasma aldosterone and blood pressure has been studied in 6 normotensive subjects, on a constant sodium intake. Average serum digoxin level measured in 5 subjects on the 5th day of treatment was in the upper range of the therapeutic level (1.92 +/- 0.3 nmol/l). Red cell sodium content increased from 9.75 +/- 1.2 mmol/l of cells in the control period to 15.3 +/- 1.7 mmol/l of cells on the 5th day of digoxin treatment when measured in 4 of the 6 subjects. In spite of this evidence of inhibition of the red cell sodium pump, there was no detectable change in sodium excretion, blood pressure, plasma renin activity and aldosterone.
D000284:Administration, Oral; D001794:Blood Pressure / Q000187:drug effects*; D004077:Digoxin / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D011187:Posture; D011188:Potassium / Q000652:urine; D012084:Renin-Angiotensin System / Q000187:drug effects*
D004077:Digoxin; D011188:Potassium