Sympathetic nervous system and glioma growth.
C-6 glioma cells possess beta-adrenergic receptors on the cell surface. Activation of beta-adrenergic receptors with beta-adrenergic agonists increases intracellular levels of cAMP and leads to differentiation of C-6 glioma cells in vitro. The present study shows that growth of C-6 glioma tumor in rats with ablated sympathetic nervous system is augmented as compared to controls. Lack of normal noradrenergic stimulation of C-6 glioma cells may lower intracellular cAMP and allow unrestricted growth of this tumor.
D000818:Animals; D005910:Glioma / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D051381:Rats; D011920:Rats, Inbred WF; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000503:physiopathology*