Heparin prophylaxis of Henoch-Schoenlein nephropathy.
Eighty eight children with extrarenal manifestations of Henoch-Schoenlein purpura received 120-150 IU/kg heparin in infusion for three days at onset and at relapses. Nephropathy developed in one child (1.1%), whereas renal involvement was noticed in 14 out the 67 control patients with Henoch-Schoenlein purpura (20.9%). The difference was highly significant (p less than 0.001).
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications*; D008297:Male; D009393:Nephritis / Q000209:etiology / Q000517:prevention & control*
D006493:Heparin