title: Percutaneous renal surgery and local radiotherapy in the management of renal pelvic transitional cell carcinoma.
abstract: Six patients with a history of bladder carcinoma and a radiographic filling defect of the pelvicaliceal system have been investigated or treated percutaneously. In two cases of doubtful diagnosis, percutaneous pyeloscopy showed that no pelvicaliceal tumour was present. In four patients with multifocal or recurrent transitional cell carcinoma and difficult clinical problems, intrarenal tumours were cauterised or resected percutaneously. Radioactive iridium wire (192Ir) was inserted into the surgical track to deliver prophylactic irradiation (4500 cGy) to prevent tumour seeding. Follow-up was from 7 to 36 months. One operated patient developed early wide-spread multifocal disease throughout the urothelium, including the operated kidney, and died of uraemia. The other three patients have shown no recurrence in the operated kidney, though two have developed recurrences in the bladder or ureter. There have been no track recurrences.
mesh_terms: D000368:Aged; D001918:Brachytherapy; D002295:Carcinoma, Transitional Cell / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D007495:Iridium / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D008875:Middle Aged; D009403:Nephrostomy, Percutaneous; D011868:Radioisotopes / Q000627:therapeutic use
chemical_list: D011868:Radioisotopes; D007495:Iridium