title: Considerations of statistical power in the shared-haplotypes test.
abstract: This paper considers statistical power properties of a test of whether a disease is caused by a recessive gene, using data on HLA sharing properties of affected sibs. It is found that the test has very poor power characteristics, and in particular we are sometimes just as likely to accept the hypothesis that the gene is recessive when it is dominant as when it is truly recessive.
mesh_terms: D002648:Child; D005808:Genes, Recessive; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D013223:Statistics as Topic
chemical_list: D006680:HLA Antigens