Hyaluronidase and sodium hyaluronate in cataract surgery.
The use of sodium hyaluronate in cataract surgery and intraocular lens implantation is often followed by a postoperative rise of intraocular pressure. A trial is described in which 10 patients underwent bilateral cataract extraction and Binkhorst intraocular lens implantation with the use of sodium hyaluronate. The enzyme hyaluronidase was instilled into the anterior chamber of the right eye only, to aid removal of sodium hyaluronate, and resulted in a statistically significant lowering of postoperative intraocular pressure in right eyes compared with left. Other uses of the enzyme are discussed.
D000368:Aged; D000867:Anterior Chamber; D002387:Cataract Extraction; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism*; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use*; D007429:Intraocular Pressure / Q000187:drug effects; D007910:Lenses, Intraocular; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control
D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase