Adenosine analogues. The temperature-dependence of the anticonvulsant effect and inhibition of 3H-D-aspartate release.
Following the intraperitoneal administration of the adenosine analogues, 2-chloro-adenosine (1-4 mg/kg) or 5'-N-ethylcarboxamidoadenosine (NECA; 0.01-0.5 mg/kg) to audiogenic DBA/2 mice, there is a potent protection against sound-induced seizures and a simultaneous large (2-5 degrees) reduction in body temperature. The anticonvulsant potency of the adenosine analogues is almost completely abolished by pretreatment with methylxanthines or warming the mice to prevent the adenosine-induced temperature decrease. Adenosine (0.01-1 mM), 2-chloro-adenosine (0.1-1 mM) and NECA (0.1 mM) also significantly inhibit potassium-evoked release of 3H-D-aspartate from rat hippocampal slices. This inhibition is not affected by theophylline (1 mM).
D015762:2-Chloroadenosine; D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D019830:Adenosine-5'-(N-ethylcarboxamide); D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001224:Aspartic Acid / Q000378:metabolism*; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009043:Motor Activity / Q000187:drug effects; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013806:Theophylline / Q000494:pharmacology; D014316:Tritium
D000927:Anticonvulsants; D014316:Tritium; D015762:2-Chloroadenosine; D001224:Aspartic Acid; D019830:Adenosine-5'-(N-ethylcarboxamide); D013806:Theophylline; D000241:Adenosine; D011188:Potassium