Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism.
MDL 72222, the selective 5-hydroxytryptamine (5-HT) M-receptor antagonist, prevented or reduced cisplatin-induced emesis in ferrets. It is suggested that cisplatin-induced, and possibly other cytotoxic drug-induced vomiting may involve a 5-HT M-receptor mechanism.
D000818:Animals; D002945:Cisplatin / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005289:Ferrets; D008297:Male; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D014326:Tropanes / Q000494:pharmacology*; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D014326:Tropanes; C042253:bemesetron; D002945:Cisplatin