Characterization and properties of Mg2+ uptake and release from guinea pig cerebral cortex synaptosomes.
The transport of Mg2+ into and out of guinea pig cerebral cortex synaptosomes was studied. Experiments are reported showing that the influx of Mg2+ (at low synaptosomal ATP) specifically requires a physiologically oriented Na+ gradient across the plasma membrane. It is also shown that an outwardly directed energy dependent Mg2+ pump is present in the synaptosomal plasma membrane; this pump, which requires ATP, is inhibited at high synaptosomal (Na+).
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex / Q000166:cytology*; D004072:Digitonin / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006168:Guinea Pigs; D008274:Magnesium / Q000378:metabolism*; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D013779:Tetrodotoxin / Q000494:pharmacology
D013779:Tetrodotoxin; D010042:Ouabain; D000255:Adenosine Triphosphate; D012964:Sodium; D008274:Magnesium; D005947:Glucose; D004072:Digitonin; D011188:Potassium