Diarrhea and malabsorption in calves associated with therapeutic doses of antibiotics: absorptive and clinical changes.
Of 28 healthy, nondiarrheal, colostrum-fed neonatal calves, 22 developed diarrhea after they were given (orally) for 3 to 5 days maximally recommended doses of chloramphenicol, neomycin, ampicillin, or tetracycline. Ampicillin-, neomycin-, or tetracycline-treated calves had significantly (P less than 0.05) decreased and delayed glucose absorption during oral glucose tolerance tests. Chloramphenicol-treated calves had significantly (P less than 0.05) higher base-line plasma glucose concentrations during the non-test period and had no significant increase in blood glucose concentrations during the tolerance tests compared with those in control calves.
D000667:Ampicillin / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced*; D002701:Chloramphenicol / Q000008:administration & dosage / Q000009:adverse effects; D003967:Diarrhea / Q000139:chemically induced / Q000662:veterinary*; D005951:Glucose Tolerance Test / Q000662:veterinary; D006400:Hematocrit / Q000662:veterinary; D007773:Lactates / Q000097:blood; D008286:Malabsorption Syndromes / Q000139:chemically induced / Q000662:veterinary*; D008297:Male; D009355:Neomycin / Q000008:administration & dosage / Q000009:adverse effects; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013752:Tetracycline / Q000008:administration & dosage / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D001786:Blood Glucose; D001798:Blood Proteins; D007773:Lactates; D002701:Chloramphenicol; D000667:Ampicillin; D012964:Sodium; D013752:Tetracycline; D009355:Neomycin; D011188:Potassium