The effect of intravenous lidoflazine on serotonin-induced cerebral vascular contraction--an in vivo study.
Lidoflazine, a piperazine derivative with known selectivity for vascular smooth muscle, was evaluated as a possible agent for prophylaxis of cerebral vascular contraction induced by subarachnoid perfusion with serotonin. The animals treated with serotonin (5 X 10(-6) M), had a 60% reduction in the diameter of basilar artery but when pretreated with Lidoflazine (1 mg/kg) intravenously, only had a 20% reduction in diameter (p less than 0.01). Lidoflazine, when administered intravenously at a slow rate will not adversely lower systemic blood pressure and can prevent the contraction of cerebral vessels when the stimulus for contraction is in the subarachnoid space.
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects* / Q000502:physiology; D007275:Injections, Intravenous; D008013:Lidoflazine / Q000008:administration & dosage / Q000494:pharmacology*; D010477:Perfusion; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology*; D013346:Subarachnoid Space; D014661:Vasoconstriction / Q000187:drug effects*
D010879:Piperazines; D012701:Serotonin; D008013:Lidoflazine