title: Inhibition of fatty acid mobilization by arterial free fatty acid concentration.
abstract: Subcutaneous, inguinal adipose tissue from dogs was perfused with blood in which the free fatty acid (FFA) concentration was varied corresponding to FFA/albumin molar ratios between 1 and 6. Otherwise the composition of the perfusate was kept constant. In order to stimulate lipolysis, isoprenaline and theophyllamine were added to the perfusate. A raise in arterial FFA/albumin molar ratio was without influence on lipolysis (as reflected in the release of glycerol), but reduced the FFA release indicating an increased re-esterification. At FFA/albumin ratios above 3 a marked increase in vascular resistance was seen. This increase was partly reversible within the time of a perfusion. When lipolysis is stimulated in the intact organism, the effects of increasing arterial FFA/albumin ratio on re-esterification and vascular resistance may serve as feedback mechanisms regulating FFA mobilization.
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D004951:Esterification; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D005947:Glucose / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology; D008066:Lipolysis / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D010477:Perfusion; D011312:Pressure; D012709:Serum Albumin / Q000032:analysis; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D005230:Fatty Acids, Nonesterified; D012709:Serum Albumin; D000628:Aminophylline; D005947:Glucose; D007545:Isoproterenol