Monoclonal phosphorylcholine antibody binds to beta-lipoprotein from different animal species.
Previously published observations have demonstrated that murine antibody with specificity for phosphorylcholine (PC) binds to a variety of PC-containing polysaccharides and to human beta-lipoprotein. In this investigation it was found that monoclonal anti-PC antibody binds not only to human beta-lipoprotein, but also to beta-lipoprotein from the serum of all vertebrate species examined. beta-Lipoprotein from mouse reacted with autologous antibody; therefore, this antibody must be an autoantibody. This raises the question whether PC antibodies may exert unwanted effects after having been passively transferred or induced by PC-containing antigens, e.g., C-polysaccharide from pneumococci.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology; D001667:Binding, Competitive; D002645:Chickens; D002794:Choline / Q000031:analogs & derivatives*; D006224:Cricetinae; D005777:Geese; D006736:Horses; D006801:Humans; D007122:Immunoelectrophoresis; D008077:Lipoproteins, LDL / Q000276:immunology*; D051379:Mice; D010767:Phosphorylcholine / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013552:Swine
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D008077:Lipoproteins, LDL; D010767:Phosphorylcholine; D002794:Choline