The effect of oestradiolum benzoicum and progesterone on AChE activity in the nerves of the female reproductive system of immature pigs.
The present paper describes the effect of exogenous oestradiol and progesterone on the AChE activity in nerves of the ovary, oviduct, uterus, and vagina, and on morphological features of the AChE-positive nerves of these organs in sexually immature pigs. Studies were carried out on 30 sexually immature pigs, 37 to 43 kg in weight, at the age of 115 to 125 d, of the BWP (Big White Polish) race. The animals were divided into 4 groups. Group I (n = 6) constituted the control. Animals in group II (n = 8) received oestradiolum benzoicum. Those in group III (n = 8) were given progesterone, and in group IV (n = 8) oestradiol and progesterone. Oestradiol injections resulted in a 1.2-fold increase of AChE activity in the ovary, 1.3-fold in the oviduct, 1.7-fold in the uterine horn, and a 1.2-fold decrease of this activity in the cervix, while no differences were noted in the vagina. Progesterone injections did not affect AChE activity in the ovary, while a 1.1-fold increase was observed in the oviduct, 1.2-fold in the uterine horn and 1.1-fold in the cervix compared to the control. A 1.1-fold decrease of this activity was observed in the vagina. Joint injections of oestradiol and progesterone resulted in about a 1.4-fold increase of AChE activity in the ovary, 1.3-fold in the oviduct, 1.4-fold in the uterine horn, 1.6-fold in the vagina, while no changes were observed in the cervix. The results suggest the effect of the administered hormones upon AChE activity in the organs under study, mainly in the oviduct, uterine horn, and vagina. They also point to the possibility of a synergic effect of oestradiol and progesterone as regards to an increase of the activity.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002584:Cervix Uteri / Q000294:innervation; D002799:Cholinergic Fibers / Q000187:drug effects / Q000201:enzymology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005187:Fallopian Tubes / Q000294:innervation; D005260:Female; D005836:Genitalia, Female / Q000294:innervation*; D010053:Ovary / Q000294:innervation; D010525:Peripheral Nerves / Q000187:drug effects* / Q000201:enzymology; D011374:Progesterone / Q000494:pharmacology*; D013552:Swine; D014599:Uterus / Q000294:innervation; D014621:Vagina / Q000294:innervation
D002800:Cholinesterase Inhibitors; D011374:Progesterone; D004958:Estradiol; D000110:Acetylcholinesterase