Effect of the pretreatment with pyrazole, cystamine or diphenyl-P-phenylenediamine (DPPD) on the CCl4-promoted pentane evolution in rats.
CCl4 administration to Sprague-Dawley male rats promotes pentane evolution which is an index of lipid peroxidation (LP) occurrence in vivo. Pyrazole (150 mg/kg, ip) or cystamine (600 mg/kg, po) pretreatment do not prevent CCl4-induced increases in pentane evolution, while the prior administration of the powerful antioxidant DPPD (600 mg/kg, ip at 48, 24 and 10 minutes before CCl4) prevents most of it. Since previous studies evidenced that pyrazole and cystamine but not DPPD prevent several early effects of CCl4 and diminish the intensity of the covalent binding of CCl4 reactive metabolites to cellular constituents (CB), results suggest that CB and LP might be related to those deleterious effects of CCl4 on the liver.
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D003538:Cystamine / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008297:Male; D010420:Pentanes / Q000378:metabolism*; D010655:Phenylenediamines / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D008054:Lipid Peroxides; D010420:Pentanes; D010655:Phenylenediamines; D011720:Pyrazoles; C031280:pyrazole; C033353:pentane; D002251:Carbon Tetrachloride; C004845:N,N'-diphenyl-4-phenylenediamine; D003538:Cystamine