title: Action of histamine on PHA chemiluminescence response of blood mononuclear cells in autoimmune patients.
abstract: Peripheral blood mononuclear cells (PBMs) of patients suffering from autoimmune diseases showed significantly lower chemiluminescence response to PHA than the controls. High doses of histamine (10(-5) M) inhibited the chemiluminescence while low doses caused a mild enhancement in all groups of patients. The preformed histamine content of the PBMs was not significantly higher in the patients than in the controls. Individually, a reverse correlation was found between the activity of the disease and the sensitivity of the cells to histamine. In very active cases, virtually no inhibition by histamine was found.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D002927:Cimetidine / Q000494:pharmacology; D006632:Histamine / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008163:Luminescent Measurements; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects*; D009000:Monocytes / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000494:pharmacology*; D011970:Receptors, Histamine H2 / Q000187:drug effects
chemical_list: D010835:Phytohemagglutinins; D011970:Receptors, Histamine H2; D002927:Cimetidine; D006632:Histamine