title: Some aspects of the chronological dose distribution in the radiobiology and radiotherapy.
abstract: The linear-quadratic model provides, when applied to standard fractionation schemes, results comparable to the Ellis-formula, but it may also be applied to problems such as multifractionations, application of high single doses and afterloading methods (interstitial and intracavitary therapy with either short-time application or continuous irradiation), where the Ellis-formula is rather questionable. A further critical point of the latter formula is the estimation of late responses. However, the limitations of the linear-quadratic computation model may be determined by a comparison with a cubic survival formula S = exp (-(alpha D + beta D2 + delta D3] or with the Bender-Gooch-formula.
mesh_terms: D000818:Animals; D001918:Brachytherapy; D001921:Brain / Q000528:radiation effects; D003201:Computers; D006801:Humans; D007422:Intestines / Q000528:radiation effects; D051379:Mice; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000532:radiotherapy; D012867:Skin / Q000528:radiation effects; D012878:Skin Neoplasms / Q000532:radiotherapy; D013997:Time Factors