title: Fecapentaene-12 causes DNA damage and mutations in human cells.
abstract: Fecapentaenes are mutagens found in human feces and may play a role in the pathogenesis of colon carcinoma. However, the genotoxic effects of fecapentaenes have not been previously studied in mammalian cells. We now report that fecapentaene-12 (fec-12), a prototype for these compounds, causes DNA single strand breaks, sister chromatid exchanges and mutations in cultured human fibroblasts. These results indicate that fec-12 is a potent genotoxic agent in human cells.
mesh_terms: D002478:Cells, Cultured; D003110:Colonic Neoplasms / Q000139:chemically induced; D004247:DNA; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009153:Mutagens; D009154:Mutation; D011090:Polyenes / Q000633:toxicity*
chemical_list: D009153:Mutagens; D011090:Polyenes; C037357:1-(1-glycero)dodeca-1,3,5,7,9-pentaene; D004247:DNA