The metabolism of n-octane in Fischer 344 rats.
The urinary metabolites of n-octane in Fischer 344 rats given the hydrocarbon by gavage included 2-octanol, 3-octanol, 5-oxohexanoic acid, and 6-oxoheptanoic acid. The sex of the animals influenced the relative amounts of metabolites formed. Analyses were performed by gas-liquid chromatography (GC) and gas-liquid chromatography/mass spectrometry (GC/MS). This is the first reported finding of keto acids in hydrocarbon oxidative metabolism. No kidney damage was found as a result of n-octane dosing although the 2,2,4-trimethylpentane (iso-octane) isomer does cause kidney lesions in male rats.
D000284:Administration, Oral; D000818:Animals; D002849:Chromatography, Gas; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009795:Octanes / Q000378:metabolism* / Q000633:toxicity; D000442:Octanols / Q000652:urine*; D051381:Rats; D011916:Rats, Inbred F344; D012737:Sex Factors
D009795:Octanes; D000442:Octanols; C026728:octane