[Role of monoamines in the pathogenesis of sex maturation disorders].
Serotonin and norepinephrine levels in the hypothalamus and blood of albino female rats with a normal and abnormal course of puberty were studied to find a solution to the problem of the role of monoamines in the pathogenesis of pubertal disorders. Intense physical exercise the 21- and 40-day animals were subjected to, was used to simulate a delay in puberty. It was established that the nature and intensity of disorders of the sexual system were determined, to a certain extent, by changes in the monoamine content in the hypothalamus over time. A significant rise of the serotonin level and a simultaneous decrease in the epinephrine level were revealed in the rats with delayed puberty. Possible mechanisms of the role of monoamines in the pathogenesis of pubertal disorders, function of the female sexual system in the period of puberty are discussed.
D000818:Animals; D004195:Disease Models, Animal; D004958:Estradiol / Q000097:blood; D005260:Female; D007031:Hypothalamus / Q000032:analysis*; D009638:Norepinephrine / Q000032:analysis*; D005082:Physical Exertion; D011628:Puberty, Delayed / Q000503:physiopathology; D051381:Rats; D012701:Serotonin / Q000032:analysis* / Q000097:blood; D012741:Sexual Maturation; D014621:Vagina / Q000254:growth & development
D012701:Serotonin; D004958:Estradiol; D009638:Norepinephrine
Rol' monoaminov v patogeneze narusheniĭ polovogo sozrevaniia.