title: Standards for Clostridium chauvoei vaccine--the relationship between the response of guinea pigs and sheep following vaccination and challenge with virulent C. chauvoei.
abstract: Twelve commercial 5-component clostridial vaccines with known variations in potency of the blackleg (Clostridium chauvoei) component, were simultaneously tested in sheep and guinea pigs. Controlled challenge experiments provided evidence of a highly significant correlation in the response of the 2 species. The guinea pig laboratory model is considered to be a valid indicator of field performance for vaccines containing blackleg antigen.
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology / Q000592:standards*; D003013:Clostridium / Q000276:immunology*; D003015:Clostridium Infections / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*; D014611:Vaccination / Q000662:veterinary*
chemical_list: D001428:Bacterial Vaccines