[Protein kinase activity and phosphorylation of endogenous proteins in the rat colonic mucosa during chemical carcinogenesis].
Treatment with a single dose of 21 mg/kg, of 1,2-dimethylhydrazine was followed by a significant decrease in the level of cAMP-dependent protein kinase (histone kinase) in rats' large bowel mucosa after 72 hrs. However, its level returned to basal value after 2 weeks, with casein kinase level remaining unchanged. Both carcinogen--induced tumors of the large bowel and adjacent mucosa showed a drop in protein (mol. wt.-50 kdalton) was enhanced in tumor considerably.
D019813:1,2-Dimethylhydrazine; D000230:Adenocarcinoma / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000378:metabolism*; D004127:Dimethylhydrazines; D007413:Intestinal Mucosa / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D010750:Phosphoproteins / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats
D004127:Dimethylhydrazines; D010750:Phosphoproteins; D011506:Proteins; D011494:Protein Kinases; D019813:1,2-Dimethylhydrazine
Aktivnost' proteinkinaz i fosforilirovaniia éndogennykh belkov v slizistoĭ obolochke tolstoĭ kishki krysy pri khimicheskom kantserogeneze.