title: Effect of loperamide on faecal control after rectoplasty for high imperforate anus.
abstract: The effect of loperamide on faecal control after Stephens rectoplasty for high imperforate anus was studied in eight patients more than 8 years after surgery. Clinical assessment and anorectal manometry were performed before and after administration of loperamide for 6 to 8 weeks. Decreased faecal soiling was noted in seven of the eight cases. Obstipation forced two patients to stop the medication. The improved faecal control was verified by an increase in squeeze pressure at anorectal manometry in four patients. When incontinence persists after Stephens rectoplasty, loperamide can improve the faecal control in some cases.
mesh_terms: D000293:Adolescent; D001003:Anal Canal / Q000503:physiopathology; D001006:Anus, Imperforate / Q000601:surgery*; D002648:Child; D005242:Fecal Incontinence / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D008139:Loperamide / Q000627:therapeutic use*; D008365:Manometry; D010880:Piperidines / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy; D011312:Pressure; D012007:Rectum / Q000503:physiopathology / Q000601:surgery*
chemical_list: D010880:Piperidines; D008139:Loperamide