Effect of ethanol, acetaldehyde and acetate on the antioxidant-sensitive respiration in the perfused rat liver: influence of fasting and diethylmaleate treatment.
The infusion of 45 mM ethanol or 50 microM acetaldehyde into the perfused rat liver produced comparable and significant antioxidant-sensitive respiratory rates, while marginal responses were obtained with 10 mM acetate. Ethanol-induced antioxidant-sensitive respiration was markedly increased in perfused livers from fasted rats or animals given diethylmaleate which exhibit low hepatic glutathione levels, compared to fed rats. These data point out the significant role of acetaldehyde in ethanol-induced liver oxidative stress, which can be exacerbated by glutathione depletion.
D000079:Acetaldehyde / Q000494:pharmacology*; D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D005215:Fasting; D005978:Glutathione / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008298:Maleates / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D000975:Antioxidants; D008298:Maleates; D000431:Ethanol; C014476:diethyl maleate; D005978:Glutathione; D000079:Acetaldehyde