title: Pulmonary and cardiovascular consequences of immediate fixation or conservative management of long-bone fractures.
abstract: We randomly assigned patients with multiple trauma who had tibial or femoral fractures to one of two groups--one group received immediate fixation of all fractures, and the second group received conservative orthopedic management, consisting of traction or plaster casts. Studies were conducted twice each day for four days following injury. Mean cardiac index was 1.3 L/min/m2 higher and mean shunt was 5.2% lower in the immediate fixation group compared with the group receiving conservative treatment. Other pulmonary and systemic hemodynamic variables did not differ between the groups. The incidence of fat macroglobules in blood aspirated from the pulmonary capillaries was higher when compared with that in pulmonary arterial blood but was not significantly different between the two treatment groups. Platelet count was significantly lower and fibrinogen concentration was significantly higher in the group receiving immediate fixation. We found no diagnostic significance of the incidence of fat macroglobules in samples of blood aspirated from the pulmonary circulation. We conclude that patients receiving immediate fixation had less pulmonary dysfunction following multiple trauma and long-bone fractures.
mesh_terms: D000293:Adolescent; D000328:Adult; D002302:Cardiac Output; D004620:Embolism, Fat / Q000209:etiology; D005260:Female; D005264:Femoral Fractures / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D005340:Fibrinogen / Q000032:analysis; D005592:Fracture Fixation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011652:Pulmonary Circulation; D012119:Respiration; D013978:Tibial Fractures / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D013997:Time Factors
chemical_list: D005340:Fibrinogen