Interaction of positively charged liposomes with erythrocyte membrane. An ultrastructural study.
Structural perturbations of positively charged sonicated liposomes (L) induced by incubation with human erythrocytes have been studied by thin-section electron microscopy. It has been found that just after mixing with cells L bind to cell surfaces and fuse with each other, first forming larger L and then flattened multilamellar structures. Successive fusion events occurring in the latter result in a reduced number of bilayers which gradually comes to a single one.
D000588:Amines; D000818:Animals; D002645:Chickens; D004530:Egg Yolk; D004910:Erythrocyte Membrane / Q000648:ultrastructure*; D006801:Humans; D008081:Liposomes; D008854:Microscopy, Electron; D010713:Phosphatidylcholines
D000588:Amines; D008081:Liposomes; D010713:Phosphatidylcholines; C009317:stearylamine