title: Evaluation of the effect of glucan on hepatic, renal and mammary tumorigenesis in rats.
abstract: Glucan was evaluated for its ability to modify the hepatic and renal tumorigenesis induced in partially hepatectomized Sprague-Dawley female rats by diethylnitrosamine (DEN) and phenobarbital (PB), and the mammary tumorigenesis induced in intact Sprague-Dawley female rats by N-nitrosomethylurea (NMU). In both models the rats received every two weeks i.v. glucan (10 mg/kg) or equivalent amounts of dextrose. The results indicated that glucan did not significantly modify the incidence of the chemically-induced hepatic, renal and mammary tumors.
mesh_terms: D000818:Animals; D004052:Diethylnitrosamine; D005260:Female; D005936:Glucans / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D006498:Hepatectomy; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D008325:Mammary Neoplasms, Experimental / Q000473:pathology* / Q000517:prevention & control; D008770:Methylnitrosourea; D010634:Phenobarbital; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005936:Glucans; D004052:Diethylnitrosamine; D008770:Methylnitrosourea; D005947:Glucose; D010634:Phenobarbital