title: [Significance of antithrombin III in kidney diseases].
abstract: This article deals with the clinical importance of antithrombin III (AT III) in renal disease. Patients with nephrotic syndrome demonstrates a high risk of thromboembolism. A renal AT III loss is an important pathogenetic factor in these events. Patients with serumalbumin below 2.0 g/dl are mostly endangered. In patients with acute oligoanuric renal failure low AT III-levels due to consumption were often found that lead to diminished protection against intravascular coagulation processes and can therefore contribute to progression of illness. An AT III-substitution may be of some benefit in these patients. Additionally AT III was given in patients with dialysis-dependent renal failure and low levels of AT III leading to a reduced incidence of thrombosis of the extracorporeal system. Unnecessary high doses were also avoided and a minimal heparinization could be performed more efficiently in bleeding risk patients. Furthermore, AT III-levels during renal transplantation and during organ rejection are reported.
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood; D000990:Antithrombin III / Q000032:analysis*; D020152:Antithrombin III Deficiency; D005260:Female; D005337:Fibrin / Q000032:analysis; D006801:Humans; D007674:Kidney Diseases / Q000097:blood*; D009404:Nephrotic Syndrome / Q000097:blood / Q000150:complications; D011247:Pregnancy; D011644:Puerperal Disorders / Q000097:blood; D012306:Risk; D018805:Sepsis / Q000097:blood; D013923:Thromboembolism / Q000209:etiology; D013927:Thrombosis / Q000209:etiology
chemical_list: D000990:Antithrombin III; D005337:Fibrin
vernacular_title: Bedeutung von Antithrombin III bei Nierenerkrankungen.