Parasite-induced suppression of the immune response in Aedes aegypti by Brugia pahangi.
The melanization response against intrathoracically inoculated Brugia pahangi and Dirofilaria immitis microfilariae (mff) isolated from vertebrate host blood was evaluated in both uninfected Aedes aegypti black-eyed Liverpool strain and in mosquitoes harboring a developing B. pahangi infection. The immune response against inoculated mff of either species was significantly reduced by 28-47% in infected as compared with uninfected mosquitoes. Attempts to passively transfer this suppression factor(s) by inoculating naive mosquitoes with 0.1-0.2 microliter of hemolymph from B. pahangi-infected mosquitoes produced equivocal results. The role this parasite-induced immune suppression might play in aiding parasite survival in compatible vectors is discussed.
D000330:Aedes / Q000276:immunology* / Q000378:metabolism / Q000469:parasitology; D000818:Animals; D002009:Brugia / Q000276:immunology* / Q000469:parasitology; D006458:Hemolymph / Q000276:immunology / Q000469:parasitology; D006790:Host-Parasite Interactions; D007116:Immunization, Passive; D007165:Immunosuppression Therapy; D008543:Melanins / Q000378:metabolism; D008842:Microfilariae / Q000276:immunology / Q000469:parasitology
D008543:Melanins