Cumene hydroperoxide-supported denitrification of 2-nitropropane in uninduced mouse liver microsomes.
Cumene hydroperoxide supported oxidative denitrification of 2-nitropropane was investigated in uninduced mouse liver microsomes. The cytochrome P-450 peroxygenase catalyzed reaction resulted in the production of nitrite and acetone. Several lines of evidence suggested the involvement of multiple forms of cytochrome P-450. Acetone production was at least two times greater than nitrite release possibly due to sequestration of nitrite in the reaction mixtures.
D000473:Alkanes / Q000378:metabolism*; D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D009595:Nitroparaffins / Q000378:metabolism*; D011407:Propane / Q000031:analogs & derivatives* / Q000378:metabolism; D011506:Proteins / Q000378:metabolism
D000473:Alkanes; D001555:Benzene Derivatives; D009595:Nitroparaffins; D011506:Proteins; D003577:Cytochrome P-450 Enzyme System; C016617:2-nitropropane; C007164:cumene hydroperoxide; D011407:Propane