title: Sleep deprivation alters the cell population kinetics in the jejunum of the male Syrian hamster (Mesocricetus auratus).
abstract: The proliferative and functional units of the jejunum were studied every 3 hr during 24 hr in groups of control and sleep-deprived hamsters. Peaks in kinetic parameters were evident during the sleep period in control hamsters; in the absence of sleep, peak values were significantly reduced. Sleep deprivation was associated with reduction of G2 to M flux and reduction of the circadian rhythm in mitotic index from 74% to 25%. The reduction in the number of cells passing through M was reflected by a drop in labelling index 9 hr later. These findings are consistent with the theory that sleep promotes restorative processes.
mesh_terms: D000818:Animals; D002452:Cell Count; D002453:Cell Cycle; D002465:Cell Movement; D002940:Circadian Rhythm; D006224:Cricetinae; D004435:Eating; D007413:Intestinal Mucosa / Q000166:cytology / Q000502:physiology; D007583:Jejunum / Q000166:cytology* / Q000502:physiology; D008297:Male; D008647:Mesocricetus; D008940:Mitotic Index; D012892:Sleep Deprivation / Q000502:physiology