The potent tremorgenic neurotoxins lolitrem B and aflatrem: a comparison of the tremor response in mice.
Tremor dose-response curves were determined for mice dosed with the ryegrass neurotoxin lolitrem B, and the tremor-genic mycotoxin aflatrem. A family of characteristic curves was revealed for each tremorgenic, with lolitrem B eliciting a sustained tremor response persisting for over 24 h.
D000818:Animals; D004121:Dimethyl Sulfoxide; D004305:Dose-Response Relationship, Drug; D005260:Female; D026121:Indole Alkaloids; D007211:Indoles / Q000008:administration & dosage; D007700:Kinetics; D051379:Mice; D009183:Mycotoxins / Q000008:administration & dosage; D009422:Nervous System Diseases / Q000139:chemically induced; D014202:Tremor / Q000139:chemically induced*
D026121:Indole Alkaloids; D007211:Indoles; D009183:Mycotoxins; C019239:aflatrem; C033673:lolitrem B; D004121:Dimethyl Sulfoxide