Tiamulin in drinking water for treatment and development of immunity to swine dysentery.
The diarrhea of swine dysentery receded in swine treated with 60 or 45 mg of tiamulin/L of drinking water (60 or 45 ppm). However, within 2 to 10 days (average 4.1 days) after drug withdrawal, diarrhea recurred. Tiamulin (22.5 mg/L in drinking water) did not markedly reduce the diarrhea during medication, and tylosin (66 mg/L in the drinking water) was not effective. In swine treated with 120 mg of dimetridazole/L of drinking water, there was no recurrence of diarrhea. After the recurrence of diarrhea in swine, repeated medication with tiamulin in drinking water reduced the severity of diarrhea and prevented deaths. After 1 to 3 retreatments, swine were immune to exposure with swine dysentery inoculum, and there was a significant (P less than 0.05) increase in their serum anti-Treponema hyodysenteriae antibodies. Seemingly, drug withdrawal permitted the occurrence and recurrence of diarrhea that was necessary to stimulate immunity.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D004224:Diterpenes / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use; D004403:Dysentery / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D007933:Leucomycins / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use; D012008:Recurrence; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000276:immunology; D014211:Treponemal Infections / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*; D014881:Water Supply
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D007933:Leucomycins; C014224:tiamulin