title: Antineoplastic agents, 116. An evaluation of the marine ascidian Aplidium californicum.
abstract: The antineoplastic constituents of the marine ascidian Aplidium californicum were found to be bryostatins 4 and 5. Bioassay-directed isolation procedures using the National Cancer Institute's P-388 lymphocytic leukemia system led to the bryostatins. The probable symbiotic relationship between A. californicum and the bryozoan Bugula neritina was discussed.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy; D014561:Urochordata / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents