Electrical stimulation of neurointermediate lobes of mice elicits calcium-dependent output of melanocyte-stimulating hormone.
Current pulses applied to isolated neurointermediate lobes of mice increased output of melanocyte-stimulating hormone. This response was dependent on extracellular calcium over a wide range of stimulus intensities and thus appears to be a true secretory response from the melanotrophs. Since substantial responses persisted in the presence of tetrodotoxin, much of the effect seems to be independent of Na spiking.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D004558:Electric Stimulation; D005260:Female; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology
D013779:Tetrodotoxin; D009074:Melanocyte-Stimulating Hormones; D002118:Calcium