Antibacterial activity of GO 10213, a nitroimidazole derivative.
Compound GO 10213, a 5-nitroimidazole substituted at the 2 position, is more active against aerobic, microaerophilic, and anaerobic bacteria than metronidazole. The MICs for Salmonella typhimurium (2 to 128 micrograms/ml), Campylobacter spp. (0.06 to 16 micrograms/ml) and Bacteroides spp. (0.03 to 0.25 micrograms/ml) are definitely lower than those of metronidazole. Niridazole, a 5-nitrothiazole, is still more active.
D000994:Antitrichomonal Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009560:Niridazole / Q000494:pharmacology; D009593:Nitroimidazoles / Q000494:pharmacology*
D000994:Antitrichomonal Agents; D009593:Nitroimidazoles; D008795:Metronidazole; C034473:satranidazole; D009560:Niridazole