Role of sulfate conjugation of catecholamines in blood pressure regulation.
Catecholamine sulfates were found to be inactive at vascular receptor sites. Only at one nonvascular receptor site important for blood pressure (BP) regulation was dopamine-3-O-sulfate found to be an inhibitory modulator of the adrenocortical secretion of aldosterone in vitro. However, sulfation of catecholamines (CA) does play an important role in BP regulation, as shown by the following observations: Sulfoconjugated CA with a long half-life are sometimes better markers of CA release than free CA, which have short half-lives. This is particularly true of dopamine (DA) sulfate because free DA, being rapidly sulfoconjugated, is usually undetectable. This led to the recognition of a previously unsuspected role of DA in paroxysmal hypertension and orthostatic hypotension. Measurements of CA sulfates reveal potentially important storage functions for sulfoconjugation that can rapidly inactivate excessive circulating free CA and so mitigate their cardiovascular impact while building up a pool of conjugated CA. The possibility that free CA can be generated from this pool through deconjugation whenever a need for them arises should be further investigated. Reproducible individual differences in the velocity of the sulfoconjugation of infused free CA can be detected, which suggests a genetic control of certain components of the sulfoconjugating process. These differences in sulfoconjugation probably modulate the cardiovascular action of CA and of some drugs with similar structure that also undergo sulfoconjugation.
D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000378:metabolism; D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism; D004285:Dogs; D004298:Dopamine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology; D004837:Epinephrine / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology / Q000235:genetics; D009638:Norepinephrine / Q000378:metabolism / Q000494:pharmacology; D010673:Pheochromocytoma / Q000150:complications / Q000378:metabolism; D011954:Receptors, Dopamine / Q000502:physiology; D012636:Secretory Rate / Q000187:drug effects
D002395:Catecholamines; D011954:Receptors, Dopamine; C022807:dopamine 4-O-sulfate; D000450:Aldosterone; C007558:dopamine 3-O-sulfate; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine