Dextroamphetamine-induced arousal in human subjects as a model for mania.
Because of the practical difficulties which arise in studying manic patients, a reproducible model for mania using human subjects would be a valuable adjunct to research in this condition. Dextroamphetamine, given as a single oral 20 mg dose, fulfils the criteria for such a model in that there are very close similarities between the changes which occur after dextroamphetamine and those which have been observed in mania in terms of subjective experience, physiological and endocrine changes, and response to pharmacological agents.
D000284:Administration, Oral; D000328:Adult; D000339:Affect / Q000187:drug effects; D001143:Arousal / Q000187:drug effects*; D001714:Bipolar Disorder / Q000139:chemically induced*; D001794:Blood Pressure / Q000187:drug effects; D003913:Dextroamphetamine / Q000097:blood / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005712:Galvanic Skin Response / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010868:Pimozide / Q000494:pharmacology; D011581:Psychological Tests
D010868:Pimozide; D003913:Dextroamphetamine