title: Fever induced by labetalol.
abstract: Fever caused by beta-adrenoceptor blocking agents is rare. We describe fever in two patients who had been treated with labetalol. In both patients, two challenge periods were rapidly followed by a relapse, whereas on each occasion there was normalization of temperature after discontinuation of the drug therapy. This reaction is rare and unpredictable. Because there was a clear sensitization period of three to four weeks, dose independency, and an accelerated reaction to rechallenge, this adverse effect seems to be caused by an immunoallergic reaction.
mesh_terms: D000368:Aged; D004306:Dose-Response Relationship, Immunologic; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D007741:Labetalol / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D007741:Labetalol