title: Chronic pernio. A historical perspective of cold-induced vascular disease.
abstract: Chronic pernio, or cold-induced vascular disease, is an uncommon syndrome with a clinical resemblance to vasculitis or peripheral cholesterol embolization. We studied a case of chronic pernio in which the angiogram revealed extensive vascular changes indistinguishable from vasculitis; pathologic studies of previously reported cases have revealed a primary vasculopathy. The pathophysiology of chronic pernio may be cold-induced vessel damage leading to a secondary dermopathy. Our patient's condition improved once the correct diagnosis was established and appropriate therapy was instituted.
mesh_terms: D000368:Aged; D000792:Angiography; D002647:Chilblains / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D002908:Chronic Disease; D003080:Cold Temperature / Q000009:adverse effects; D003937:Diagnosis, Differential; D005260:Female; D005627:Frostbite / Q000175:diagnosis*; D006225:Hand / Q000098:blood supply; D006801:Humans; D014652:Vascular Diseases / Q000175:diagnosis / Q000209:etiology; D014657:Vasculitis / Q000139:chemically induced