Antimicrobial activity of borate-buffered solutions.
A minimal salts medium adjusted to physiological pH and osmolality was buffered with either 0.3% phosphate or 1.2% borate and evaluated for antimicrobial activity. The borate-buffered medium, either with or without a carbon source, exhibited significant antimicrobial activity against 15 Pseudomonas strains, 12 strains of enteric bacteria, and 7 strains of staphylococci. The borate-buffered system appears suitable for use as a generic vehicle for ophthalmic pharmaceutical agents.
D000900:Anti-Bacterial Agents; D001881:Borates / Q000494:pharmacology*; D002021:Buffers; D003470:Culture Media; D004755:Enterobacteriaceae / Q000187:drug effects; D011549:Pseudomonas / Q000187:drug effects; D012996:Solutions; D013210:Staphylococcus / Q000187:drug effects; D013997:Time Factors
D000900:Anti-Bacterial Agents; D001881:Borates; D002021:Buffers; D003470:Culture Media; D012996:Solutions