Interaction of furosemide and phenytoin in the rat.
The interaction of phenytoin and furosemide was examined in rats. After 2 or more weeks of pretreatment with phenytoin, the diuretic activity of furosemide given orally was decreased. This was due primarily to a generalized decrease in absorption from the gastrointestinal tract. Following intravenous administration of furosemide to phenytoin pretreated rats, a decrease in diuretic activity also occurred. Excretion of furosemide was not altered. Thus, phenytoin pretreatment would also appear to interfere directly with the renal action of furosemide.
D000284:Administration, Oral; D000818:Animals; D004231:Diuresis / Q000187:drug effects; D005665:Furosemide / Q000037:antagonists & inhibitors* / Q000652:urine; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008297:Male; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010672:Phenytoin; D005665:Furosemide