[Active analog of the inactive "sleep peptide"].
Delta Sleep-Inducing Peptide (DSIP) was not previously found to possess hypnogenic properties. Its analogue (D-TrpI)DSIP was more stable against aminopeptidases. Its intracerebrovascular administration in doses of 0.7, 7 and 70 micrograms/kg body weight induced a significant increase in slow wave sleep (by 40%; p less than 0.01, U-test) and rectal temperature elevation (by 0.9 degrees C; p less than 0.01) within the following 3 day-light hours, as compared to the control rabbits treated with physiologic saline. Intravenous injections of the DSIP analogue increased slow wave sleep by 25% in a narrow dose range (30-70 micrograms/kg).
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D003701:Delta Sleep-Inducing Peptide / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D012890:Sleep / Q000187:drug effects*
D009842:Oligopeptides; D003701:Delta Sleep-Inducing Peptide; C048847:delta sleep-inducing peptide, Trp(1)-
Aktivnyĭ analog neaktivnogo "peptida sna".