Development of erosive gastritis in a canine model of esophageal varices.
We designed a reproducible canine model of esophageal varices, based on the concept of a regional hyperdynamic state in the upper stomach. Arterialization of the left gastric vein concomitant with the distal splenorenal shunt led to a stable hyperdynamic state and reproducible esophageal varices occurred. In the long-term follow-up of these dogs with varices, the erosive gastritis seen in the upper stomach clearly resembled clinically observed lesions. Hemodynamic and morphological studies revealed that gastric mucosa of these animals was in an ischemic state, even though there was a remarkable increase in blood flow in the submucosal area. It is suggested that the decrease in mucosal blood flow, as induced by the hyperdynamic state caused erosive gastritis.
D000818:Animals; D004285:Dogs; D004932:Esophageal and Gastric Varices / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D005753:Gastric Mucosa / Q000098:blood supply; D005756:Gastritis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008833:Microcirculation / Q000473:pathology; D012039:Regional Blood Flow