title: Ultrastructural changes in mollicutes induced by the peptide antibiotic herbicolin A.
abstract: Electron microscopy of negatively stained mycoplasma, ureaplasma, and acholeplasma cells showed ultrastructural changes after 10 min of treatment of the organisms with the peptide antibiotic herbicolin A in concentrations ranging from 10 micrograms/ml for Mycoplasma capricolum to 600 micrograms/ml for Ureaplasma urealyticum. The morphological changes were shown to be reversible at low concentrations of the antibiotic but irreversible at high concentrations.
mesh_terms: D000127:Acholeplasma / Q000187:drug effects* / Q000648:ultrastructure; D000128:Acholeplasma laidlawii / Q000187:drug effects / Q000648:ultrastructure; D008854:Microscopy, Electron; D009174:Mycoplasma / Q000187:drug effects* / Q000648:ultrastructure; D009842:Oligopeptides; D010455:Peptides / Q000494:pharmacology; D014509:Ureaplasma / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D009842:Oligopeptides; D010455:Peptides; C027099:herbicolin A