title: Ethanol reduces myoglobin release during isokinetic muscle exercise.
abstract: Changes in serum myoglobin concentrations were studied in 12 healthy males performing a standardized isokinetic 2-min exercise test. The test was performed on three separate occasions: in the habitual state, during moderate ethanol intoxication and one day after ethanol intake. Although the performed muscle work, maximal heart rate, and blood lactate levels did not differ between the three test occasions, the serum myoglobin increments after exercise were significantly reduced (p less than 0.05) in the ethanol-intoxicated state and also 10-15 hours after ethanol intake. The reduction of the exercise-induced myoglobin increment was not explained by increased elimination of the protein. The mechanism, therefore, is likely to be a reduction of myoglobin release from skeletal muscle due to an ethanol-induced alteration of the muscle cell membrane, possibly by means of adenylate cyclase activation.
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D007773:Lactates / Q000097:blood; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects*; D009211:Myoglobin / Q000097:blood / Q000378:metabolism*
chemical_list: D007773:Lactates; D009211:Myoglobin; D000431:Ethanol