An immunoreactive peptide in milk contains bombesin-like bioactivity.
Parallel in vitro bioassays using rat uterus and guinea pig large intestine tissues specific for the bombesin family of peptides, demonstrated that the bombesin-like peptides present in bovine milk can produce a dose-related response similar to bombesin and litorin. The bioactivity of this type of milk peptide appeared to be approximately 20-50% as active as the amphibian peptides. These data support the proposal that a bombesin immunoreactive peptide in milk contains bombesin bioactivity.
D000818:Animals; D001681:Biological Assay; D001839:Bombesin / Q000494:pharmacology*; D002417:Cattle; D005260:Female; D006168:Guinea Pigs; D007420:Intestine, Large / Q000502:physiology; D008892:Milk / Q000032:analysis*; D009119:Muscle Contraction / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects
D009842:Oligopeptides; C010212:litorin; D001839:Bombesin