title: [Changes in the coagulation system in shock].
abstract: Disorders of the coagulation system in shock are caused by injuries of the endothelium, influx of thromboplastic material into the blood and stasis. In this way, the intrinsic and the extrinsic system is activated. Fibrin is generated in the blood stream and forms high molecular complexes together with fibrinogen (hypercoagulability). With progress of the shock fibrin can deposit in the small vessels with the consequence of impaired circulation. Finally clotting factors and inhibitors (e.g. antithrombin III) are consumed by disseminated intravascular coagulation. This results in a bleeding tendency (consumption coagulopathy). In this survey particular shock formes (endotoxin induced, cardiogenic, traumatic, hemorrhagic) are discussed with regard to the reflections of the blood coagulation. The therapy of shock-induced disorders of blood coagulation are focused on treatment of primary disease, prevention or elimination of microthrombi, substitution of blood respective plasma components.
mesh_terms: D001777:Blood Coagulation; D005337:Fibrin / Q000502:physiology; D006487:Hemostasis; D006801:Humans; D011480:Protease Inhibitors / Q000097:blood; D012769:Shock / Q000097:blood* / Q000628:therapy
chemical_list: D011480:Protease Inhibitors; D005337:Fibrin
vernacular_title: Gerinnungsveränderungen im Schock.