[Modulation of ornithine decarboxylase activity in the normal and regenerating rat liver by different doses of hydra peptide morphogen].
The authors studied the anabolic effect of peptide morphogen of the hydra undecapeptide on normal and regenerating rat liver. Ornithine decarboxylase (EC 4.1.1.17) activity served as a marker. Intraperitoneal injection of the peptide into intact animals stimulated ornithine decarboxylase activity in a dose-dependent manner. In partially hepatectomized rats the peptide stimulated ornithine decarboxylase activity in the dose of 20 micrograms/kg body weight while greater doses inhibited the enzyme activity.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D008099:Liver / Q000201:enzymology*; D008115:Liver Regeneration; D008297:Male; D009479:Neuropeptides; D009842:Oligopeptides / Q000494:pharmacology*; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains
D009479:Neuropeptides; D009842:Oligopeptides; C032522:head activator peptide; D009955:Ornithine Decarboxylase; D011761:Pyrrolidonecarboxylic Acid
Moduliatsiia aktivnosti ornitindekarboksilazy v normal'noĭ i regeneriruiushcheĭ pecheni krys razlichnymi dozami peptidnogo morfogena gidry.