Pretreatment of young mice with nerve growth factor enhances scopolamine-induced hyperactivity.
Twenty-one-day-old mice show a characteristic enhancement of locomotor activity upon injection of the cholinergic (muscarinic) blocking drug scopolamine. Intracerebral (third ventricle) injection of nerve growth factor (NGF) 24 h prior to scopolamine injection significantly enhances the drug-induced hyperactivity without modifying baseline activity. Such potentiation of the scopolamine effect was not obtained in 10-week-old mice treated and tested similarly.
D000367:Age Factors; D000818:Animals; D004357:Drug Synergism; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D012601:Scopolamine / Q000494:pharmacology*; D013268:Stimulation, Chemical
D009414:Nerve Growth Factors; D012601:Scopolamine