Transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) via placenta and milk, and postnatal toxicity in the mouse.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) was found to be efficiently transferred to mouse neonates and offspring by lactating mothers. During the first 2 postnatal weeks the pups received doses of TCDD via the milk which were, on a body weight basis, similar to those which had been administered prenatally to their mothers. The distribution of TCDD in the offspring (high in liver, low in other tissues) was similar to that found in the maternal organism. Maternal TCDD levels rapidly decreased during the lactation period while tissue levels in the nursing pups increased, resulting in offspring tissue levels which greatly exceeded those of their mothers at the respective 3-week periods after birth. The postnatal development of pups from mothers treated on days 14-17 of gestation and nursed by untreated foster mothers was studied. Postnatal mortality was increased. Surviving animals did not exhibit visible signs of abnormal development, although the reduced number of pups per litter may have contributed to this apparently normal development. In small rodents excretion into milk constituted a major pathway for the elimination of maternal TCDD. Whether the same holds true for man is still unknown, but the measurement of TCDD levels in breast milk may be an appropriate and practical method for the assessment of human exposure to this substance.
D000375:Aging; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004147:Dioxins / Q000378:metabolism*; D005260:Female; D006128:Growth / Q000187:drug effects; D007700:Kinetics; D051379:Mice; D008892:Milk / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D000072317:Polychlorinated Dibenzodioxins / Q000378:metabolism* / Q000633:toxicity; D011247:Pregnancy; D014018:Tissue Distribution
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins