Bioavailability of cyanamide in fasted and unfasted rats.
The pharmacokinetics of cyanamide after 35 mg kg-1 intravenous and oral administration to fasted and unfasted rats have been investigated. The plasma level are fitted well by a two-compartment open model. The half-life (t 1/2 beta) of cyanamide in the rat was 1 hour and the plasma clearance (C1p) was 0.02 (1 kg-1) min-1. Food does not appear to modify the absolute bioavailability of cyanamide (F = 93.3 per cent fasted, F = 85.5 per cent unfasted), although it does retard drug absorption.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D003484:Cyanamide / Q000097:blood / Q000378:metabolism*; D003486:Cyanides / Q000378:metabolism*; D005215:Fasting; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003486:Cyanides; D003484:Cyanamide