title: The involvement of calcium in the stimulation of respiration in isolated rat hepatocytes by adrenergic agonists and glucagon.
abstract: The effects of adrenergic agonists and glucagon on respiration and cytosolic free Ca2+, measured with quin2, in female rat hepatocytes have been compared. In the presence of lactate, all three agonists caused a permanent stimulation of respiration. However, unlike phenylephrine, glucagon induced only a transient increase in cytosolic free Ca2+, and isoprenaline caused no detectable change. Mechanisms other than Ca2+ for respiratory stimulation by cAMP-linked agonists in liver are indicated.
mesh_terms: D000634:Aminoquinolines; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000502:physiology*; D005260:Female; D005456:Fluorescent Dyes; D005934:Glucagon / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000634:Aminoquinolines; D005456:Fluorescent Dyes; D010656:Phenylephrine; C035738:Quin2-acetoxymethyl ester; D005934:Glucagon; D007545:Isoproterenol; D002118:Calcium