The antimitotic activities of some benzodiazepines.
Among 9 benzodiazepines, tested on the proliferation of synchronously dividing flagellate cells, only diazepam and medazepam can induce an accumulation of abnormal mitotic figures after 24 h of treatment. It seems that there is not a direct relation between the activity of benzodiazepines on the central nervous system and their ability to inhibit mitosis.
D001569:Benzodiazepines / Q000494:pharmacology*; D000460:Chlorophyta / Q000166:cytology / Q000187:drug effects; D002875:Chromosomes / Q000648:ultrastructure; D002998:Clonazepam / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D005445:Flunitrazepam / Q000494:pharmacology; D008472:Medazepam / Q000494:pharmacology; D008938:Mitosis / Q000187:drug effects*; D009567:Nitrazepam / Q000494:pharmacology
D001569:Benzodiazepines; D002998:Clonazepam; D005445:Flunitrazepam; D009567:Nitrazepam; D008472:Medazepam; D003975:Diazepam