Nicardipine: protection against brain hypoxia.
Nicardipine, a new vasodilator and calcium antagonist, was tested for antihypoxic activity on the central nervous system. Two methods were used: hypobaric hypoxia and alteration of the electrocorticogram by asphyxic anoxia. Both survival time and the impaired electrical signal were improved by nicardipine. These results suggest brain protection by increased cerebral blood supply.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D004569:Electroencephalography; D002534:Hypoxia, Brain / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009529:Nicardipine; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D009529:Nicardipine; D009543:Nifedipine