title: [The synthesis and biologic activity of analogs of 1,4-benzoquinone-guanylhydrazone-thiosemicarbazone. 2. Substitution at the quinone ring by alkyl groups].
abstract: Because of the anticancer activity of 1,4-benzoquinone-guanylhydrazone-thiosemicarbazone (1a) some analogues were synthesized, containing alkyl groups at the quinone moiety. If necessary, the structure of the obtained compounds was confirmed by 1H-NMR-spectroscopy. The anticancer and the antibacterial activities were investigated. The guanylhydrazone-thiosemicarbazones of tolu-,p-xylo-and thymo-quinone showed much lower activities not only against the murine leukemias L 1210 and P 388, but also against Bacillus subtilis ATCC 6633. No correlation could be found between the biological activity and the redox potential.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011048:Polarography; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D013882:Thiosemicarbazones
vernacular_title: Zur Synthese und biologischen Wirksamkeit von Analogen des 1,4-Benzochinon-guanylhydrazon-thiosemicarbazons. 2. Mitteilung: Substitution am Chinonring durch Alkylreste.