Calcium entry blocking activity of adenosine potentiating compounds in guinea pig taenia coli.
Calcium entry blocking activities of adenosine and its potentiating drugs, dilazep, lidoflazine and dipyridamole, were studied in potassium (100 mM)-depolarized guinea pig taenia coli, and compared with nifedipine, verapamil and diltiazem. The potency ratio of calcium entry blocking effect of nifedipine, diltiazem, lidoflazine and dilazep to verapamil was 158.5, 1/1.1, 1/15.8 and 1/81.3, respectively. Dipyridamole and adenosine had negligible calcium entry blocking effects.
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects; D004109:Dilazep / Q000494:pharmacology; D004110:Diltiazem / Q000494:pharmacology; D004176:Dipyridamole / Q000494:pharmacology; D004357:Drug Synergism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008013:Lidoflazine / Q000494:pharmacology; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D009543:Nifedipine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D004176:Dipyridamole; D014700:Verapamil; D004110:Diltiazem; D004109:Dilazep; D009543:Nifedipine; D008013:Lidoflazine; D000241:Adenosine; D011188:Potassium