title: Chromosome Y-specific DNA is transferred to the short arm of X chromosome in human XX males.
abstract: Y-chromosomal DNA is present in the genomes of most human XX males. In these cases, maleness is probably due to the presence of the Y-encoded testis-determining factor (TDF). By means of in situ hybridization of a probe (pDP105) detecting Y-specific DNA to metaphases from three XX males, it was demonstrated that the Y DNA is located on the tip of the short arm of an X chromosome. This finding supports the hypothesis that XX maleness is frequently the result of transfer of Y DNA, including TDF, to a paternally derived X chromosome.
mesh_terms: D002478:Cells, Cultured; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D008677:Metaphase; D009693:Nucleic Acid Hybridization; D012729:Sex Chromosome Aberrations; D012732:Sex Determination Analysis; D014960:X Chromosome; D014998:Y Chromosome
chemical_list: D004247:DNA