title: Attempted vaccination of jirds (Meriones unguiculatus) against Brugia pahangi with radiation attenuated infective larvae.
abstract: Jirds were vaccinated by three to five subcutaneous (SC) injections of infective larvae of Brugia pahangi which had been irradiated at 25, 45 or 90 krads from a 60Co source. They were challenged either SC or intraperitoneally. Vaccination with four doses of 50 larvae irradiated with 25 krads produced 49.3% resistance to IP challenge worms and 39.8% against SC challenge worms. Five doses of larvae irradiated with 45 krads produced 62% resistance to SC challenge. Three doses of larvae irradiated with 90 krads produced 74.9% resistance to SC challenge and five doses produced 76.2% resistance. The reasons why irradiated larvae produce resistance whereas normal larvae do not are discussed.
mesh_terms: D000818:Animals; D002009:Brugia / Q000276:immunology* / Q000528:radiation effects; D004605:Elephantiasis, Filarial / Q000517:prevention & control*; D005260:Female; D005849:Gerbillinae; D007814:Larva; D008209:Lymphedema / Q000517:prevention & control*; D008297:Male; D014611:Vaccination; D014613:Vaccines, Attenuated
chemical_list: D014613:Vaccines, Attenuated