Experimental efficacy of apalcillin and cefpiramide compared with that of six other antipseudomonal agents in Pseudomonas aeruginosa burn infections.
The therapeutic efficacy of cefpiramide and apalcillin was evaluated and compared with that of six other antipseudomonal beta-lactam antibiotics in an experimental mouse burn infection due to Pseudomonas aeruginosa. Both cefpiramide and apalcillin were as potent as cefsulodin and more potent than carbenicillin, cefotaxime, cefoperazone, piperacillin and gentamicin in protecting the infected mice from fatal bacteraemia and in eradicating Ps. aeruginosa from the infected site.
D000667:Ampicillin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002056:Burns / Q000150:complications*; D002511:Cephalosporins / Q000627:therapeutic use*; D005260:Female; D051379:Mice; D009287:Naphthyridines; D011552:Pseudomonas Infections / Q000188:drug therapy*; D014946:Wound Infection / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D009287:Naphthyridines; C012122:apalcillin; D000667:Ampicillin; C036666:cefpiramide