title: [Preventive chemotherapy of superficial tumors of the bladder].
abstract: A retrospective study of 135 patients with superficial transitional cancer of bladder (pTa - pT1) was conducted after follow-up for at least 3 years following treatment for 2 years at the "Instituto de Urología, Nefrología y Andrología (Fundación Puigvert)". Patients had been randomly allocated for treatment with: RTU alone, RTU + instillation of Thiotepa and RTU followed by instillations of Adriamycin. Chemotherapy was administered preventively. Recurrence after 3 years and possible progression towards infiltration during this period were evaluated, and the usefulness of this type of treatment questioned because of the cost/benefit ratio and small intergroup differences found.
mesh_terms: D000287:Administration, Topical; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Traitement chimioprophylactique des tumeurs superficielles de la vessie.