title: [Malignant change in the lymphoepithelial lesion of the parotid gland--report of 3 cases].
abstract: 3 rare cases of malignant change of lymphoepithelial lesion (Mikulicz's disease) of parotid gland are presented. 1 was male and 2 female. Their ages ranged from 40 to 71 with an average of 57 years. All were pathologically proved. The common clinical manifestations were local painless masses. 2 of the 3 cases were treated only by local excision. Extended excision with simultaneous neck dissection of the metastatic lymph nodes was done in the remained one. All patients received postoperative radiotherapy at doses of 3,000-5,000 rad over 19 to 36 days. One of them died 2.5 years later. The other two are still living without evidence of recurrence more than 3 and 8 years respectively. The prognosis of malignant Mikulicz's disease is probably better than that of parotid carcinoma. The authors suggest that the treatment of this disease, especially in those with regional metastasis, be managed according to the same principle of parotid cancer. Postoperative radiotherapy should be given as a routine for still better results. The clinico-pathologic features and pathogenesis of this disease are discussed briefly.
mesh_terms: D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008882:Mikulicz' Disease / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D010305:Parotid Diseases / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D010307:Parotid Neoplasms / Q000473:pathology*; D011182:Postoperative Care