Myopathy with mitochondrial abnormalities and rimmed vacuoles.
A man of 44 years suffering from an exercise-induced neuromuscular disease with mitochondrial abnormalities and rimmed vacuoles is reported. The mitochondrial abnormalities and rimmed vacuoles (autophagic vacuoles) are interpreted as sequential changes of the same pathogenetic process depending on the degree of energy deficiency.
D005121:Extremities; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000648:ultrastructure*; D009135:Muscular Diseases / Q000473:pathology*; D009940:Organoids / Q000648:ultrastructure*; D014617:Vacuoles / Q000648:ultrastructure*