Sensitizing capacity of dihydroxydiphenyl methane (bisphenol F) in the guinea pig.
The sensitizing capacity of 2,2(1)-dihydroxydiphenyl methane (2,2(1)-HPM), 4,4(1)-dihydroxydiphenyl methane (4,4(1)-HPM) and 2,4(1)-dihydroxydiphenyl methane (2,4(1)-HPM) was investigated with the guinea pig maximization test. These compounds are known contact sensitizers in phenol-formaldehyde resins. The study was performed to assess and compare their sensitizing capacities. A weak sensitizing capacity of 2,2(1)-HPM was demonstrated when the results for 2 separate series were added, while no sensitizing capacity was demonstrated for 4,4(1)-HPM or 2,4(1)-HPM. The compounds tested were chromatographically pure.
D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D006168:Guinea Pigs; D010328:Patch Tests; D010636:Phenols; D012117:Resins, Synthetic / Q000633:toxicity*; D013329:Structure-Activity Relationship; D000098833:Bisphenol F Compounds
D001559:Benzhydryl Compounds; D010636:Phenols; D012117:Resins, Synthetic; C047969:2,2'-bisphenol F; D000098833:Bisphenol F Compounds; C047971:2,4'-bisphenol F; C008745:4,4'-bisphenol F