Monitoring the histogenesis of colonic tumors in the Sprague-Dawley rat.
A total of 306 male Sprague-Dawley rats, injected with dimethylhydrazine (DMH), dose 21 mg/kg body weight s.c., were investigated. Of the 109 rats receiving the dose once only, seven colonic adenocarcinomas developed; all seven (100%) were seen to originate in discrete lymphoid patches. Of the 97 rats treated with one dose/week for 3 months, only 6% of the 50 adenocarcinomas developed in discrete lymphoid patches, while 46% were seen to originate in a pre-existing adenoma. Of the remaining 100 rats, receiving one dose/week for 6 months, only 3.5% of the 57 adenocarcinomas arose from discrete lymphoid patches; 43.9% arose from a pre-existing adenoma. Thus, the histogenesis of adenocarcinomas at our laboratory appears to be dose-dependent. Experiments are therefore being designed to monitor in detail the events of these two histogenetically different adenocarcinomas in the colonic mucosa in our animal model.
D019813:1,2-Dimethylhydrazine; D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D004127:Dimethylhydrazines; D004305:Dose-Response Relationship, Drug; D007413:Intestinal Mucosa / Q000473:pathology; D008221:Lymphoid Tissue / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002273:Carcinogens; D004127:Dimethylhydrazines; D019813:1,2-Dimethylhydrazine