[Mechanism of inhibition of acid secretion into the stomach by peptides of kappa-casein].
The inhibitory effect of peptides formed in a reaction of limited proteolysis on stimulated gastric acid secretion was studied in rats as well as the changes of gastrin level in the blood serum and antral gastric mucosa. The acid secretion decreased after intraluminal administration of the peptide by 51% in the rat isolated stomach, and gastrin level decreased by 8.3% in the blood serum. The mechanism of action of peptide derived from K-casein was discussed.
D000818:Animals; D002364:Caseins / Q000494:pharmacology*; D003864:Depression, Chemical; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D008297:Male; D010418:Pentagastrin / Q000037:antagonists & inhibitors; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014805:Vitamin B 12 / Q000037:antagonists & inhibitors
D002364:Caseins; D010446:Peptide Fragments; D010418:Pentagastrin; D014805:Vitamin B 12
Issledovanie mekhanizma ingibirovaniia sekretsii kisloty v zheludke peptidami kappa-kazeina.