Kinetics of 2,4,6-trichlorophenol in different organs of the rat.
The concentration of 2,4,6-trichlorophenol was measured in the blood and various other tissues of the rat after IP administration of the compound at 25 mg per kg body weight. The highest concentration, 329 +/- 117 nmol X g-1, was found in the kidney. Half-times were between 1.4 and 1.8 h in the blood, brain, fat, kidney, liver and muscle. The extent of conjugation of 2,4,6-trichlorophenol was also investigated by measuring total and free chlorophenol in the blood.
D000818:Animals; D002733:Chlorophenols / Q000097:blood / Q000378:metabolism*; D002849:Chromatography, Gas; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D007700:Kinetics; D009929:Organ Size; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D002733:Chlorophenols; D005965:Glucuronates; C024564:2,4,6-trichlorophenol