Starvation-induced microautophagic vacuoles in rat myocardial cells.
During prolonged starvation the heart atrophies and loses protein mass. Debate lingers over the basic mechanisms in the production of negative cardiac protein balance during starvation. The extent to which cardiac proteolysis takes place within the lysosomal vacuolar system is unknown. The present communication examines the starvation-induced changes within the lysosomal system of rat myocardial cells, as studied by means of conventional electron-microscopic techniques. Special attention has been paid to the occurrence of microautophagic vacuoles. It is concluded that during prolonged starvation microautophagic vacuoles appear in rat myocardial cells, suggesting the induction of a microautophagic pathway of lysosomal proteolysis.
D000818:Animals; D001343:Autophagy; D008247:Lysosomes / Q000502:physiology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009124:Muscle Proteins / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D013217:Starvation / Q000378:metabolism / Q000473:pathology*; D014617:Vacuoles / Q000648:ultrastructure
D009124:Muscle Proteins