Inhibition of proliferative activity by cyclic dipeptides: spirocyclic derivatives of 1-aminocyclopentane-carboxylic acid.
The antiproliferative activity of spirocyclic cyclodipeptides containing 1-aminocyclopentanecarboxylic acid (Acp) was investigated and compared with Pro-Leu-Gly-NH2 (MIF), cyclo(Gly-Leu) and cyclo (Sar-Sar), a compound with denaturing activity, employing the chick embryonic caudal morphogenetic system. Out of the compounds tested, MIF and cyclo(Acp-Ala) appear to exhibit the least inhibitory activity on growth.
D000596:Amino Acids / Q000633:toxicity*; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002642:Chick Embryo; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000633:toxicity*; D004151:Dipeptides; D013329:Structure-Activity Relationship
D000596:Amino Acids; D004151:Dipeptides; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane