A simple method for the synthesis of cholesteryl ethers.
A novel method for the synthesis of cholesteryl ethers is described. The mesylates of fatty alcohols were treated with the sodium salt of cholesterol in toluene at 80 degrees C in the presence of anhydrous dimethyl formamide. The hexyl, tetradecyl, and oleyl cholesteryl ethers were synthesized in yields varying between 55 and 70%. Tritiated cholesteryl oleyl ether was also synthesized in good chemical (45%) and radiochemical (45%) yields.
D002784:Cholesterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D004126:Dimethylformamide; D008722:Methods
C023511:cholesteryl oleyl ether; C048982:cholesteryl hexyl ether; C048983:cholesteryl tetradecyl ether; D004126:Dimethylformamide; D002784:Cholesterol