In vitro susceptibility of Brucella melitensis to new cephalosporins crossing the blood-brain barrier.
The in vitro susceptibilities of 83 clinical isolates of Brucella melitensis to seven cephalosporins and a monobactam were determined. Ceftizoxime, ceftriaxone, and cefotaxime were the most effective agents tested, with MICs ranging from 0.25 to 2 micrograms/ml. Moxalactam, cefoperazone, cefuroxime, and ceftazidime showed MICs between 4 and 64 micrograms/ml, with moxalactam being the most active agent in this group. Aztreonam showed poor activity, with MICs higher than 64 micrograms/ml.
D001398:Aztreonam / Q000494:pharmacology; D001812:Blood-Brain Barrier; D002002:Brucella / Q000187:drug effects*; D002006:Brucellosis / Q000382:microbiology; D002511:Cephalosporins / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests
D002511:Cephalosporins; D001398:Aztreonam