[Radioprotective effect of drug combinations on the small intestine].
The study of the radioprotective effect of complexes containing small amounts of cystamine or gammaphos mixed with mexamine, gutimine and ethyrone on mouse small intestine showed high efficiency of the drugs as determined by cellularity and DNA-synthesizing activity of intestinal epithelium. This is connected with the influence of the complex mexamine + gutimine + ethyrone on the pharmacodynamics and pharmacokinetics of cystamine and gammaphos.
D000818:Animals; D002452:Cell Count; D003538:Cystamine / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects; D004359:Drug Therapy, Combination; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage*
D011837:Radiation-Protective Agents; D004247:DNA; D003538:Cystamine
Radiozashchitnoe deĭstvie sochetaniĭ preparatov na tonkuiu kishku.