[Effect of chloramphenicol on the toxic and therapeutic actions of cyclophosphane].
The effect of chloramphenicol on the toxic and therapeutic action of cyclophosphamide was studied on CBA and DBA male mice. The animals were intact or infected with L1210 leukemia. It was found that the use of chloramphenicol prolonged the life-span of the mice and/or increased the number of the survivals after exposure to the lethal doses of cyclophosphamide. It reduced leukopenia and almost completely protected the animals from macular canities developing after administration of cyclophosphamide. The therapeutic effect of cyclophosphamide did not change after the use of chloramphenicol. The mechanisms of the above diverse effects of chloramphenicol on the toxic and therapeutic action of cyclophosphamide and the possibility of the use of chloramphenicol for lowering the cyclophosphamide toxicity in treatment of oncological patients are discussed.
D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000627:therapeutic use / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D007939:Leukemia L1210 / Q000188:drug therapy / Q000401:mortality; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D013997:Time Factors
D002701:Chloramphenicol; D003520:Cyclophosphamide
Vliianie khloramfenikola na toksicheskoe i lechebnoe deĭstvie tsiklofosfana.