Effects of erythromycin, josamycin and spiramycin on rat polymorphonuclear leukocyte chemotaxis.
The effects of three macrolide antibiotics were studied on rat polymorphonuclear leukocyte chemotaxis. Rats were given 25 mg/kg twice a day of either erythromycin, josamycin or spiramycin by gastric intubation for 5 days. In all cases, chemotaxis was found to be impaired by 10-20% only. As macrolides are known to reach high intracellular concentrations within polymorphonuclear leukocytes, our results suggest that these antibiotics are unlikely to exert a deleterious influence on the chemotactic response of treated patients.
D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004917:Erythromycin / Q000494:pharmacology*; D005260:Female; D007933:Leucomycins / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D007933:Leucomycins; D004917:Erythromycin