[Effect of enkephalins on the energy potential of the rat liver and cerebral cortex during an early period of traumatic shock].
The experiments were performed on 86 white male rats, weighing 180-220 g. The animals with traumatic shock revealed a decrease in ATP concentration and a rise in ADP and AMP levels in the brain cortex and hepatic tissue, resulting in the energy charge reduction. The injection of synthetic leu-enkephalin analog D-ala2-arg6-leu-enkephalin to animals with traumatic shock led to energy charge normalization in the brain cortex and increase in hepatic tissue. The mechanisms of enkephalin effect on the energy metabolism during shock are discussed.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D012774:Shock, Traumatic / Q000378:metabolism*; D013997:Time Factors
D000227:Adenine Nucleotides; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie énkefalinov na énergeticheskiĭ potentsial pecheni i kory golovnogo mozga u krys v rannem periode travmaticheskogo shoka.