Fetal growth of beef calves. II. Effect of sire on prenatal development of the calf and related placental characteristics.
Fifteen Hereford and 47 crossbred heifers were allotted by breed and body weight to be artificially inseminated to one of two Angus sires selected for progeny birth weights (L = low; H = high). Forty-two of the heifers were randomly assigned to be slaughtered at 200, 215, 230, 245 or 260 d of gestation for measurement of fetal and placental characteristics. Twenty heifers were allowed to go to term and five calves from each sire group were randomly assigned to be euthanized and dissected within 24 h after birth. Sire differences in birth weight (BW) and dystocia score (32.9 vs 35.4 kg; 1.8 vs 3.1, L vs H sires, respectively) existed (P less than .01), and there was a sire effect (P less than .01) for fetal calf weights (FW) and eviscerated calf weights (EW). However, there was a sire X calf sex interaction for BW (P less than .05), EW (P less than .01), FW (P less than .01), femur length (P less than .05), heart weight (P less than .05), kidney weight (P less than .01) and pituitary weight (P less than .01). Weight differences suggested these interactions were a result of the relationship of the organ weights to fetal body weights and the interaction effects on calf weights resulted from limitations in the maternal environment which restricted growth of H-sired male calves in utero. Sire X fetal age interaction effects were all nonsignificant (P greater than .10) except for cerebrum weight. This finding indicates that fetus and calf growth rates were parallel for the L and H sires. A sire effect was found for biceps (P less than .01) and liver weights (P less than .01), but not for cerebrum weights (P greater than .10). Increasing weight due to fetal age was attributed to hypertrophy for the cerebrum (P less than .05) and liver (P approximately equal to .01), while the biceps increased (P less than .05) by both hypertrophy and hyperplasia, as determined from deoxyribonucleic acid and protein analyses. All measured fetal organ weights except heart, when expressed as a ratio with EW, decreased (P less than .05) with increasing fetal age. Brain (cerebrum + cerebellum):liver weight ratios were higher (P less than .01) in L-sired calves (.32 vs. .28) than in H-sired calves. Total placentome weight (b' = 91; P less than .01) and placental fluid volume (b' = .32; P less than .01) were highly associated with FW, accounting for 84% of the variation in FW.(ABSTRACT TRUNCATED AT 400 WORDS)
D000818:Animals; D001724:Birth Weight; D002417:Cattle / Q000235:genetics*; D003433:Crosses, Genetic; D005314:Embryonic and Fetal Development; D005260:Female; D005838:Genotype; D008297:Male; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology*; D011247:Pregnancy