D-penicillamine decreases the H2O2 and phenylhydrazine induced lipid peroxidation in the erythrocyte membrane.
The protecting effect of D-penicillamine against hydrogen peroxide and phenylhydrazine induced haemolysis and lipid peroxidation is discussed. It might represent a possible way of action of the drug in some neonatal disorders like hyperbilirubinaemia and retrolental fibroplasia.
D000818:Animals; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000378:metabolism*; D010396:Penicillamine / Q000494:pharmacology*; D010659:Phenylhydrazines / Q000494:pharmacology*; D051381:Rats; D013050:Spectrometry, Fluorescence
D008054:Lipid Peroxides; D010659:Phenylhydrazines; D006861:Hydrogen Peroxide; D010396:Penicillamine