Modelling the interaction of small organic molecules with biomacromolecules. III. Interaction of benzoates with anti-p-(p'-azophenylazo)benzoate antibody.
A novel approach for modelling the biological activity of organic molecules, which requires simultaneous consideration of the influence of all factors (topological, steric, hydrophobic, and electronic) that determine the bioactivity, is used to study the interaction of a series of benzoates with anti-p-(p'-azophenylazo)benzoate antibody. The results obtained suggest that this biological interaction proceeds by a two-step stereospecific mechanism. The first step requires a geometrical correspondence between the benzoates and the cavity in the biomacromolecule, which enables the pharmacophore to come into close contact with the receptor. The second step is the orbitally controlled electronic interaction between the active parts of the benzoates and the antibody. The electronic interaction results from pi-charge transfer from the pharmacophore to the biomacromolecule and from the formation of pi-complexes. A proposed mathematical model for this biological interaction exhibits some statistical advantages over existing models.
D000906:Antibodies / Q000032:analysis*; D001391:Azo Compounds / Q000276:immunology*; D001565:Benzoates / Q000032:analysis* / Q000276:immunology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008954:Models, Biological
D000906:Antibodies; D001391:Azo Compounds; D001565:Benzoates; C049265:4-(4'-azophenylazo)benzoate