Effect of mercurascan on the contractility and excitability of dog papillary muscle in vitro.
The authors studied in 6 experimental series the effect of Mercurascan (2-hydromercurifluorescein and 4-hydroxymercurifluorescein) on isolated dog papillary muscle in vitro; they evaluated the magnitude and character of its electrically stimulated contractions. It was found that at concentration of 10(-3)M and 10(-4) M, Mercurascan (MSC) exerts a significant positive inotropic effect on papillary muscle. Incubation of the muscle in a medium containing MSC at the above-given concentrations significantly suppressed the positive inotropic and arrhythmogenic effect of adrenalin, added in an over-threshold dose into the nutrient medium.
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology; D004285:Dogs; D004347:Drug Interactions; D004837:Epinephrine / Q000037:antagonists & inhibitors; D005452:Fluoresceins / Q000494:pharmacology*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D009941:Organomercury Compounds / Q000494:pharmacology*; D010210:Papillary Muscles / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical; D013997:Time Factors
D002395:Catecholamines; D005452:Fluoresceins; D009941:Organomercury Compounds; C010604:mercurascan; D004837:Epinephrine