Complications of organic solvents in synthetic drug application.
Aziridinylbenzoquinone (AZQ), Acridinyl Anisidide (m-AMSA), Tenipsode Thenvlidene-Lignan-(VM-26), and PCNU are relatively new synthetic drugs believed to have a wide spectrum of antitumor activity. Preparation of these drugs for administration requires reconstitution with an organic solvent which decomposes the thermoplastic components of I.V. infusion devices and chemo-dispensing pins. The products of this decomposition may lead to cellular damage and complicate the infusion of these agents.
D000081:Acetamides / Q000009:adverse effects; D000180:Acrylic Resins; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002070:Butadienes; D004347:Drug Interactions; D007275:Injections, Intravenous / Q000295:instrumentation; D010969:Plastics; D011137:Polystyrenes; D012997:Solvents / Q000009:adverse effects*
D000081:Acetamides; D000180:Acrylic Resins; D000970:Antineoplastic Agents; D002070:Butadienes; D010969:Plastics; D011137:Polystyrenes; D012997:Solvents; C024636:ABS resin; C013959:dimethylacetamide