Effects of phenobarbital on lipid peroxidation in vitamin-E-deficient rats.
Increased serum lipid peroxide (LPO) and decreased vitamin E (VE) levels have been reported in epileptic children after long-term anticonvulsant therapy. The present study was designed to examine the acute effects of phenobarbital (PB) on lipid peroxidation in VE deficient rats. Five-day treatment with PB (75 mg/kg/day, IP) caused a significant increase in liver LPO levels (P less than 0.01), a decrease in plasma LPO levels (P less than 0.02), and a significant decrease in liver VE levels (P less than 0.05). It is suggested that PB plays an important role in lipid peroxidation in the liver by interfering with VE metabolism.
D000818:Animals; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D014810:Vitamin E / Q000097:blood / Q000378:metabolism; D014811:Vitamin E Deficiency / Q000097:blood / Q000378:metabolism*
D008054:Lipid Peroxides; D014810:Vitamin E; D010634:Phenobarbital