Use of alpha-tocopherylquinone in the treatment of ulcerative colitis.
The effect of alpha-tocopherylquinone (alpha-TQ) and a low fat diet on a patient with chronic continuous ulcerative colitis was described. The patient's condition improved dramatically with both colonic and extraintestinal manifestations of the disease greatly reduced with doses of alpha-TQ of 3.0 g/day (50 mg/kg/d) or greater. Withdrawal of alpha-TQ for periods of one to two days produced recurrence of inflammation which was again reduced upon re-introduction of alpha-TQ.
D000328:Adult; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D004041:Dietary Fats / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D004041:Dietary Fats; D014810:Vitamin E; C024838:alpha-tocopherol quinol; D024502:alpha-Tocopherol