[Differences in the immunostimulatory activity and antitumor therapeutic effect of OK-432 and N-CWS].
Immunobiological activities of OK-432 and N-CWS were studied in BALB/c-Meth-A and C3H-MH 134 systems. Peritoneal exudate cells obtained from mice injected i.p. with OK-432 or N-CWS showed stronger in vitro cytotoxicity against Meth-A and YAC-1 cells than did those from non-treated mice. Spleen cells from OK-432 or N-CWS-treated mice exhibited lower Con A mitogenic response in comparison with those from non-treated mice. When Meth-A or MH-134 tumor cells were admixed with OK-432 or N-CWS, the intradermally inoculated tumor cells showed no or slower growth than did those admixed with saline only. There were no significant differences in all the above mentioned activities between OK-432 and N-CWS, and there was no difference in the direct tumor inhibitory activity of the two agents in vitro. However, the administration of N-CWS had no therapeutic effect against i.p.-inoculated tumor cells while OK-432 showed a strong therapeutic effect by the same treatment schedule. Further studies are required to clarify the mechanisms responsible for the difference in the therapeutic effect of the two agents.
D000818:Animals; D001688:Biological Products / Q000276:immunology*; D017358:Cell Wall Skeleton; D003208:Concanavalin A / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic; D008114:Liver Neoplasms, Experimental / Q000276:immunology* / Q000628:therapy; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009088:Mucoproteins / Q000276:immunology* / Q000627:therapeutic use; D010844:Picibanil / Q000276:immunology* / Q000627:therapeutic use
D001688:Biological Products; D017358:Cell Wall Skeleton; D009088:Mucoproteins; C044553:cell wall skeleton, Nocardia; D003208:Concanavalin A; D010844:Picibanil