title: The effects of 2-deoxy-D-glucose on brown adipose tissue of lean and obese Zucker rats.
abstract: The response of brown adipose tissue (BAT) thermogenesis, as measured by mitochondrial GDP binding, of lean and obese Zucker fa/fa rats to 2-deoxy-D-glucose (2-DOG) has been investigated. 2-DOG reduced BAT mitochondrial GDP binding of lean rats but had no effect in obese rats. Adrenalectomy increased BAT GDP binding in obese rats and restored the 2-DOG inhibitory effect. Corticosterone inhibited GDP binding in lean rats and abolished the 2-DOG inhibitory effect. 2-DOG induced hyperphagia and hyperglycaemia in lean rats, but these effects were either absent or attenuated in the obese. The possibility that a glucocorticoid inhibition of glucose metabolism impairs sympathetic activity in the obese rats is discussed.
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001833:Body Temperature Regulation; D003345:Corticosterone / Q000494:pharmacology; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006963:Hyperphagia / Q000503:physiopathology; D008297:Male; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology*; D051381:Rats; D011924:Rats, Zucker
chemical_list: D001786:Blood Glucose; D003837:Deoxy Sugars; D003847:Deoxyglucose; D005947:Glucose; D003345:Corticosterone