title: DAPI-inducible common fragile sites.
abstract: DAPI, a compound specific for the AT bases of DNA, causes gaps and breaks in three human chromosome sites, at the 1q41-1q42 interface, 2q31, and 7p22. It also induces undercondensation of a chromosome site at the 13q21-13q22 interface. The first three sites have the characteristics of "common fragile sites" and are present as gaps and breaks on the chromosomes of seven individuals.
mesh_terms: D001483:Base Sequence; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D005260:Female; D005456:Fluorescent Dyes; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D007621:Karyotyping; D007962:Leukocytes / Q000648:ultrastructure; D008297:Male
chemical_list: D005456:Fluorescent Dyes; D007211:Indoles; C007293:DAPI