[Radiosensitivity of stromal precursors and mature hematopoietic stromal cells in a culture].
Radiosensitivity of hemopoietic stroma precursors from a long-term culture of murine bone marrow, as measured by the adherent cell layer implantation techniques, was characterized by D0 = 3.02 +/- 0.7 Gy and n = 1.6. Mature cells of the hemopoietic microenvironment survived after doses of up to 100 Gy. Their irreversible damage was only observed after 150-200 Gy irradiation. The results obtained support the suggestion of different histogenetical origin of the hemopoietic and stromal precursors.
D000818:Animals; D002454:Cell Differentiation / Q000528:radiation effects; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011836:Radiation Tolerance
Radiochuvstvitel'nost' stromal'nykh predshestvennikov i zrelykh kletok krovetvornoĭ stromy v kul'ture.