title: Catecholamines of endoneurial laryngeal paraganglia in the rat.
abstract: The catecholamines in the recurrent and superior laryngeal nerves of the rat were assayed by high performance liquid chromatography. The nerves were shown to contain high levels of dopamine (1.9 +/- 0.6 and 2.3 +/- 0.4 pmol, respectively) and noradrenaline (1.3 +/- 0.3 and 0.9 +/- 0.2 pmol, respectively). No adrenaline could be detected in any of the nerves. Reserpine markedly depleted the stores of these amines in both nerves. A significant increase in dopamine level was seen in the superior laryngeal nerve after treatment with a monoaminoxidase inhibitor, but not in the recurrent laryngeal nerve. The high levels of dopamine detected are presumably derived from endoneurial paraganglia which were demonstrated by glyoxylic acid-induced fluorescence. The source of noradrenaline is less evident, but noradrenaline is probably stored in both endoneurial paraganglia and in sympathetic nerve endings.
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000032:analysis*; D004837:Epinephrine / Q000032:analysis*; D007823:Laryngeal Nerves / Q000032:analysis*; D008856:Microscopy, Fluorescence; D009526:Nialamide / Q000494:pharmacology; D009638:Norepinephrine / Q000032:analysis*; D010234:Paraganglia, Nonchromaffin / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D012009:Recurrent Laryngeal Nerve / Q000032:analysis; D012110:Reserpine / Q000494:pharmacology
chemical_list: D012110:Reserpine; D009526:Nialamide; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine