[Somatotropin secretion during sleep. Application to partial somatotropin deficiency in the child].
The authors studied somatotropic secretion during sleep in 122 children who had a backward growth of at last 2 standard deviations from the mean growth. Diurnal pharmacological tests showed 73 normal responses, 49 intermediate or dissociated responses orienting toward a partial deficit of STH secretion. The study of sleep secretion shows, among normal children, a secretory response superior to those pharmacological tests with a late secretory response in 20% of cases. In the group of children suspected of having a partial deficit, the study of sleep secretion permits to discover 27 children presenting a normal secretion, and to isolate a group of real partial deficit (22 children) who should have a treatment with the human growth hormone.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy / Q000378:metabolism*; D013006:Growth Hormone / Q000172:deficiency / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D012890:Sleep / Q000502:physiology*
D013006:Growth Hormone
Etude de la sécrétion somatotrope de sommeil. Application au déficit somatotrope partiel chez l'enfant.