[Intolerance to metoclopramide (apropos of 22 case reports of infants of the black race)].
The authors report on 22 observations made from june 1982 to december 1984 in African children having presented an intolerance against metoclopramide. After recalling briefly the pharmacology of this drug, they describe the symptomatology similar to neuroleptic intoxication syndrome: parkinsonian syndrome, motor excitation syndrome. Posology was correct in 2/3 of the cases, when it was known. Overdose was observed in 5 cases only. Recovery was complete after the administration of the drug was stopped, but it was accelerated by antiparkinsonian drugs.
D000293:Adolescent; D017109:Akathisia, Drug-Induced; D001711:Biotransformation; D044383:Black People; D002648:Child; D002675:Child, Preschool; D003286:Contracture / Q000139:chemically induced; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008787:Metoclopramide / Q000009:adverse effects* / Q000378:metabolism; D010302:Parkinson Disease, Secondary / Q000139:chemically induced; D012675:Senegal
D008787:Metoclopramide
Intolérance au métoclopramide (à propos de 22 observations d'enfants de race noire).