Effects of allyl methyl trisulfide on glutathione S-transferase activity and BP-induced neoplasia in the mouse.
Allyl methyl trisulfide (AMT), a constituent of garlic oil, was studied for its effects on glutathione S-transferase (GST) activity and on benzo[a]pyrene (BP)-induced neoplasia of the forestomach and lungs of female A/J mice. AMT induced increased GST activity in the forestomach, small bowel mucosa, liver, and lung. The forestomach and small bowel mucosa responded to a single low dose of AMT (3.0 mumol) given by oral intubation, whereas liver and lung were less reactive. A dose schedule of two administrations of 15 mumol AMT given 48 hours apart gave close-to-maximum induction in all four tissues and was chosen for investigation of its inhibitory effects. With this dose schedule, AMT produced an inhibition of BP-induced neoplasia of the forestomach as shown by a greater than 70% reduction in the number of tumors found at the completion of the experiment. Inhibition of pulmonary neoplasia did not occur. AMT is a member of a new class of naturally occurring chemicals that have the capacity to inhibit chemical carcinogenesis.
D000498:Allyl Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001564:Benzo(a)pyrene; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000201:enzymology; D007421:Intestine, Small / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D008805:Mice, Inbred A; D013270:Stomach / Q000201:enzymology; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013440:Sulfides / Q000494:pharmacology* / Q000627:therapeutic use
D000498:Allyl Compounds; D013440:Sulfides; D001564:Benzo(a)pyrene; C028526:methylallyl trisulfide; D005982:Glutathione Transferase