[Bronchospasmolytic effectiveness of controlled drug combinations].
Two groups of 10 patients each with a chronic obstructive pulmonary disease were the subjects of a comparative study of the effectiveness of 240 mg theophyllinethylendiamine (Euphyllin) and a combined medication consisting of 25 mg theophyllin, 85 mg etophyllin, 30 mg papaverine and 0.1 mg atropine methylnitrate (Perphyllon). Oscillatory resistance (measured with the Siregnost FD 5) and the circulatory parameters pulse and blood pressure were studied. A statistically significant bronchospasmolytic effect was found for both substances administered parenterally. It was shown, however, that the combined medication worked faster, longer and 4 to 5 times more effectively than theophyllinethylendiamine. The possible causes of the differences are discussed. Clinically, the cardiovascular side effects of the combined medication are to be classified as slight. The tested medication has a favorable therapeutic spectrum as a result of the low dosage of the individual substances.
D000403:Airway Resistance / Q000187:drug effects; D000628:Aminophylline / Q000627:therapeutic use; D001286:Atropine Derivatives / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D001986:Bronchial Spasm / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007263:Infusions, Parenteral; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000627:therapeutic use*; D010634:Phenobarbital / Q000627:therapeutic use*; D013806:Theophylline / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D001286:Atropine Derivatives; D001993:Bronchodilator Agents; D004338:Drug Combinations; D000628:Aminophylline; C048874:perphyllon; D013806:Theophylline; D010208:Papaverine; D010634:Phenobarbital
Bronchospasmolytische Wirksamkeit kontrollierter Wirkstoffkombinationen.