Retrograde changes in the nucleus basalis of the rat, caused by cortical damage, are prevented by exogenous ganglioside GM1.
In rats with extensive unilateral cortical damage, retrograde effects upon the cholinergic cells of the basal nucleus were observed. Cells of the basal nucleus stained immunocytochemically for choline acetyltransferase were shrunken and choline acetyltransferase enzymatic activity in that region was reduced. Both these effects could be prevented by the administration of the ganglioside GM1.
D000544:Alzheimer Disease / Q000473:pathology; D000818:Animals; D001479:Basal Ganglia; D001927:Brain Diseases / Q000188:drug therapy / Q000473:pathology; D002540:Cerebral Cortex; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D005677:G(M1) Ganglioside / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013377:Substantia Innominata / Q000201:enzymology / Q000473:pathology
D005677:G(M1) Ganglioside; D002795:Choline O-Acetyltransferase