[Morpho-functional state of biomembranes after treatment with alkyl derivatives of 2,4-dinitrophenol].
The morphofunctional state of the rat liver biomembranes is studied under conditions of the peroral effect of alkyl dinitrophenols: dinitroorthocresole and secondary 2,4-dinitro-6-butylphenol. It is established that free radicals and products of peroxide lipid oxidation (diene conjugates, hydroperoxides, final products reacting with 2-thiobarbituric acid) are very important for realization of the membrane-tropic action of the above compounds. Possible mechanisms of development of the membrane-damaging action of these xenobiotics and their effect on the state of the mitochondrial respiratory chain are discussed. The membrane-tropic effect of alkyl dinitrophenols is confirmed by the results of electron-microscopic studies.
D019297:2,4-Dinitrophenol / Q000031:analogs & derivatives; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003408:Cresols / Q000494:pharmacology*; D004138:Dinitrocresols / Q000494:pharmacology*; D004140:Dinitrophenols / Q000494:pharmacology*; D005260:Female; D005609:Free Radicals; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains
D003408:Cresols; D004138:Dinitrocresols; D004140:Dinitrophenols; D005609:Free Radicals; D008054:Lipid Peroxides; C024132:4,6-dinitro-o-cresol; D019297:2,4-Dinitrophenol; C018527:dinoseb
Morfofunktsional'noe sostoianie biomembran pri vozdeĭstvii alkilproizvodnykh 2,4-dinitrofenola.