Estrogen use and cardiovascular disease.
In general, epidemiologic data from case-control and cohort studies have suggested that postmenopausal estrogen use confers a moderate degree of protection from coronary artery disease. The authors report reductions in all-cause mortality rates and in mortality rates for acute myocardial infarction among estrogen replacement users in comparison with never-users. It is calculated that even a small decline in the mortality rate for coronary artery disease among estrogen users would have a major impact on the overall risk/benefit ratio associated with estrogen use.
D000368:Aged; D002140:California; D002318:Cardiovascular Diseases / Q000401:mortality / Q000517:prevention & control*; D003327:Coronary Disease / Q000401:mortality; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008487:Medical History Taking; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality; D011446:Prospective Studies; D012306:Risk
D004967:Estrogens