[In vitro modulation using a synthetic antioxidant of the stimulus-induced formation of cyclic AMP].
The in vitro treatment of membranes isolated from different rat organs with a water-soluble synthetic antioxidant has resulted in the change of basal and stimulus-induced adenylate cyclase activity. It is believed that the antioxidant effect is realized rather at the level of signal transfer from activated receptor to adenylate cyclase than at the level of agonist-receptor interaction.
D000262:Adenylyl Cyclases / Q000096:biosynthesis*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects* / Q000201:enzymology; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D004790:Enzyme Induction / Q000187:drug effects; D005934:Glucagon / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D010666:Phenylpropionates / Q000494:pharmacology*; D051381:Rats
D000975:Antioxidants; D010666:Phenylpropionates; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D005934:Glucagon; D000262:Adenylyl Cyclases; D007545:Isoproterenol; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; C047854:fenozan
Moduliatsiia in vitro sinteticheskim antioksidantom stimulindutsirovannogo obrazovaniia tsAMF.