DC-86-M, a novel antitumor antibiotic. II. Structure determination and biological activities.
A novel antibiotic, DC-86-M was isolated from the culture broth of Streptomyces luteogriseus DO-86. The antibiotic has the molecular formula of C17H14N2O5 and belongs to the phenazine antibiotics. Its structure has been elucidated by mass and NMR spectra. It is active against Gram-positive and Gram-negative bacteria and experimental murine sarcoma 180.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification / Q000627:therapeutic use; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010619:Phenazines / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D012510:Sarcoma 180 / Q000188:drug therapy; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces
D000903:Antibiotics, Antineoplastic; D010619:Phenazines; C049724:DC 86M