Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22).
Inhalation pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22) were studied in male Wistar rats by use of a closed inhalation chamber system. CFC 21 was readily eliminated via metabolism. However, CFC 22 underwent no detectable metabolism; pretreatment of the rats with DDT or phenobarbital did not stimulate metabolic transformation of the compound. Hence, formation of biologically relevant amounts of reactive intermediates from CFC 22 as a mechanism of toxicity seems unlikely.
D000818:Animals; D001711:Biotransformation; D005617:Chlorofluorocarbons, Methane / Q000378:metabolism* / Q000633:toxicity; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005617:Chlorofluorocarbons, Methane; C009755:fluorocarbon 22; C049237:dichlorofluoromethane