title: A differential effect of the Walker 256 carcinoma on the tyrosine protein kinase activity of liver plasma membrane domains.
abstract: Protein kinase activity was investigated in plasma membrane fractions enriched in either sinusoidal or lateral domains prepared from liver of normal rats and rats bearing a Walker 256 carcinoma. Membrane proteins were phosphorylated on tyrosine, threonine and serine residues in both fractions. Phosphorylation of tyrosine residues was increased in sinusoidal preparations from tumour-bearing rats but not in lateral preparations. An increase in histone phosphorylation by sinusoidal preparations from tumour-bearing rats was found to be due to serine protein kinase activity.
mesh_terms: D000818:Animals; D002279:Carcinoma 256, Walker / Q000201:enzymology*; D002462:Cell Membrane / Q000201:enzymology; D005260:Female; D008099:Liver / Q000201:enzymology*; D008565:Membrane Proteins / Q000378:metabolism; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008565:Membrane Proteins; D011505:Protein-Tyrosine Kinases