Changes of pharmacokinetics of trimethoprim after pretreatment with streptococcal peptidoglycan.
Trimethoprim (TMP) 10 mg.kg-1 was given orally to calves and rabbits. Two to three weeks later the animals were pretreated by i.v. Peptidoglycan (Pt) 20 micrograms.kg-1. One hour later TMP was administered as above. To other animals under otherwise identical conditions TMP was injected intravenously. The pretreatment with Peptidoglycan induced in both species a significant increase of TMP serum levels positively correlated with temperature elevation. Peptidoglycan pretreatment increased the bioavailability of TMP.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002417:Cattle; D005260:Female; D005334:Fever / Q000097:blood* / Q000139:chemically induced; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D010457:Peptidoglycan / Q000494:pharmacology*; D011817:Rabbits; D014295:Trimethoprim / Q000008:administration & dosage / Q000097:blood*
D010457:Peptidoglycan; D014295:Trimethoprim