High plasma cholecystokinin response following ingestion of test meal by patients with non-insulin dependent diabetes mellitus.
Postprandial responses of plasma cholecystokinin (CCK) in patients with non-insulin dependent diabetes mellitus (NIDDM) were studied with a CCK specific radioimmunoassay. After the ingestion of a liquid test meal, plasma CCK levels increased from the basal level of 9.8 +/- 1.1 pg/ml to a peak of 19.4 +/- 1.8 pg/ml at 20 min in healthy subjects (n = 10). The ingestion of a test meal in patients with NIDDM (n = 10) resulted in a significantly greater increase of plasma CCK than in healthy subjects and a significant increase of plasma CCK from a basal level of 14.2 +/- 4.4 pg/ml to a peak of 47.4 +/- 12.4 pg/ml at 10 min.
D000328:Adult; D002766:Cholecystokinin / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004435:Eating; D005260:Female; D005526:Food, Formulated; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay / Q000379:methods; D013997:Time Factors
D002766:Cholecystokinin