title: Severe congenital factor X deficiency with intracranial haemorrhage.
abstract: A Saudi Arabian infant with severe factor X deficiency who had had two intracranial haemorrhages is described. Attempts to raise his factor X level and improve his prothrombin time (PT) and partial thromboplastin time (PTT) by using vitamin K, oestradiol and danazol have failed. New therapeutic trials are necessary for patients with severe forms of this rare disorder.
mesh_terms: D001803:Blood Transfusion; D002543:Cerebral Hemorrhage / Q000209:etiology*; D002675:Child, Preschool; D003613:Danazol / Q000627:therapeutic use; D004958:Estradiol / Q000627:therapeutic use; D005171:Factor X Deficiency / Q000150:complications / Q000151:congenital* / Q000628:therapy; D006801:Humans; D007020:Hypoprothrombinemias / Q000151:congenital*; D008297:Male; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D014812:Vitamin K / Q000627:therapeutic use
chemical_list: D014812:Vitamin K; D004958:Estradiol; D003613:Danazol