Biodegradable resurfacing of the hip in dogs.
Arthroplasties of the hips in dogs using a biodegradable poly-L-lactide cup to protect the regenerating cartilage following removal of normal articular cartilage and the drilling of multiple full thickness defects into subchondral bone were performed to determine whether or not the repair response could be improved. The poly-L-lactide cup degraded in approximately 60 days. The regenerating cartilage was much better in the experimental than the control dogs initially, but ultimately failed, perhaps due to inadequate duration of protection of the immature cartilage by the arthroplasty material.
D000818:Animals; D001673:Biodegradation, Environmental; D002358:Cartilage, Articular / Q000187:drug effects / Q000502:physiology / Q000601:surgery; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006621:Hip Joint / Q000473:pathology / Q000601:surgery*; D011091:Polyesters / Q000627:therapeutic use*; D011208:Powders; D019736:Prostheses and Implants; D012038:Regeneration / Q000187:drug effects; D013997:Time Factors
D011091:Polyesters; D011208:Powders; C033616:poly(lactide)