[Relation of the antimutagenic activity of simple phenols to the number of hydroxyl groups].
The influence of mono-phenol, di-resorcinol and tri-pyrogallol hydroxyl groups of simple unsubstituted phenols on the mutagenic potentials of benzo(a)pyrene was studied in vivo (micronuclear test on bone marrow polychromatic erythrocytes) and in vitro (test of direct point mutations at V79/HGPRT system induced by metabolic activation by mouse liver microsomal enzymes). The phenols decreased the mutagenic activity of benzo(a)pyrene in in vivo tests, with pyrogallol being the most active, it followed by resorcinol and phenol. The mixtures of benzo(a) pyrene + pyrogallol and benzo(a)pyrene + resorcinol were significantly less mutagenic in in vitro tests than benzo(a)pyrene and benzo(a)pyrene + phenol.
D000818:Animals; D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors; D051379:Mice; D009152:Mutagenicity Tests; D009154:Mutation; D019800:Phenol; D010636:Phenols / Q000494:pharmacology*; D011748:Pyrogallol / Q000494:pharmacology; D012118:Resorcinols / Q000494:pharmacology
D010636:Phenols; D012118:Resorcinols; D011748:Pyrogallol; D019800:Phenol; D001564:Benzo(a)pyrene; C031389:resorcinol
Zavisimost' antimutagennoĭ aktivnosti prostykh fenolov ot chisla gidroksil'nykh grupp.