title: S-adenosyl-L-methionine modulates phosphatidylethanolamine methyltransferase response to isoproterenol in brain.
abstract: The effect of l-isoproterenol on S-adenosyl-L-methionine (Adomet)-mediated phospholipid methylation in rat brain cortex was examined. Under conditions which favor the activity of methyltransferase I (i.e. low Adomet), formation of phosphatidyl-N-methylethanolamine was inhibited by l-isoproterenol. On the other hand, methyltransferase II activity (i.e. high Adomet) was stimulated by l-isoproterenol. The results suggest that Adomet may play a regulatory role in the response of phospholipid methyltransferases to catecholamines in brain.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002855:Chromatography, Thin Layer; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D008745:Methylation; D008780:Methyltransferases / Q000378:metabolism*; D050918:Phosphatidylethanolamine N-Methyltransferase; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012436:S-Adenosylmethionine / Q000502:physiology*
chemical_list: D010743:Phospholipids; D012436:S-Adenosylmethionine; D008780:Methyltransferases; D050918:Phosphatidylethanolamine N-Methyltransferase; D007545:Isoproterenol