Synthetic peptides related to the N-terminal amino acid sequence of a pharmacologically active decapeptide isolated from Crotalus atrox snake venom.
Synthesis is described of some peptides and peptide derivatives related to the N-terminal amino acid sequence of a pharmacologically active decapeptide (POL-236) recently isolated from Crotalus Atrox snake venom. The synthetic compounds were tested for hypotensive activity in anaesthetized normotensive rats. At the used doses all compounds failed to show the immediate hypotensive effect noted after POL-236 administration.
D000595:Amino Acid Sequence; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003435:Crotalid Venoms / Q000032:analysis* / Q000494:pharmacology; D008297:Male; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects
D003435:Crotalid Venoms; D009842:Oligopeptides