[Epoxy ring scission in the oleandomycin molecule during aging].
Opening of the epoxide ring in the molecule of oleandomycin phosphate in the process of its aging was shown to be possible by the data of the analysis. Certain correlation between the "glycol" content and drug activity was detected.
D004355:Drug Stability; D004356:Drug Storage; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D008968:Molecular Conformation; D009827:Oleandomycin / Q000032:analysis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013696:Temperature
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D009827:Oleandomycin
O raskrytii époksidnogo kol'tsa v molekule oleandomitsina v protsesse stareniia.