Tear and serum antibody levels in ocular herpetic infection: diagnostic precision of secretory IgA.
A sensitive enzyme linked immunosorbent assay (ELISA) was developed to evaluate the potential of herpes simplex virus (HSV) specific antibodies in the diagnosis of herpetic eye infection. The presence of HSV specific secretory IgA (sIgA) in tears was found to be diagnostic of infection. However, serum and tear HSV specific IgG and IgA were not considered reliable indicators of active infection.
D000914:Antibodies, Viral / Q000032:analysis*; D003320:Corneal Ulcer / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis; D007635:Keratitis, Dendritic / Q000175:diagnosis*; D007637:Keratoconjunctivitis / Q000276:immunology; D013666:Tears / Q000276:immunology*
D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G