Ketoconazole does not impair antipyrine clearance in humans.
The effect of ketoconazole on the kinetics of antipyrine was investigated. The antipyrine Vd showed an overall difference among the 4 trials, but the magnitude of the differences was small. Antipyrine half-life was slightly but not significantly shortened and the antipyrine clearance was essentially identical in the whole study. The data are commented and interpreted.
D000328:Adult; D000368:Aged; D000983:Antipyrine / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007654:Ketoconazole / Q000494:pharmacology*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged
D007654:Ketoconazole; D000983:Antipyrine