Lofexidine in alcohol withdrawal states.
Twenty-eight patients admitted to hospital for alcohol withdrawal were treated with lofexidine, an alpha adrenergic agonist of the imidazole type, in an open trial. Twenty-three patients completed the regime. Symptoms were measured on a scale developed for the study: the Alcohol Withdrawal Rating Scale (AWRS). Scores on this scale fell steeply over three days, more slowly over the subsequent four--the period of the trial. Results are compatible with the hypothesis that alcohol withdrawal states are characterised by increased adrenergic activity.
D001288:Attention / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D000431:Ethanol; D003000:Clonidine; C025655:lofexidine