Effect of hepatic artery embolization on the adenylate energy charge level and the redox state of the cirrhotic liver.
Hepatic energy charge ((ATP + 1/2ADP)/(ATP + ADP + AMP)) and arterial blood ketone body ratio (acetoacetate/3-hydroxybutyrate) were measured after hepatic artery embolization in carbon-tetrachloride-induced cirrhotic rats. In normal livers, energy charge slightly decreased at 3 h and returned to normal levels at 6 h. By contrast, in cirrhotic livers, energy charge was drastically decreased at 3 h after embolization and was not completely recovered at 6 h. Blood ketone body ratio, reflecting hepatic mitochondrial redox (NAD+/NADH) state, also decreased at 3 h after embolization in both groups, and its recovery was not observed in cirrhotic group at 6 h.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000818:Animals; D004621:Embolization, Therapeutic / Q000009:adverse effects*; D004734:Energy Metabolism; D006499:Hepatic Artery; D007657:Ketone Bodies / Q000097:blood; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D000227:Adenine Nucleotides; D007657:Ketone Bodies; D009243:NAD