[Pharmacological activity of synthetic prostaglandin analogs].
The results of studies on the biological activity of seven synthetic analogues of prostaglandins are presented. All the analogues under study possess uterotonic, antiulcer and anti-inflammatory activity; all the compounds except S1 induce diarrhea. The synthetic analogues studied decrease transiently and slightly the arterial blood pressure.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D003967:Diarrhea / Q000139:chemically induced; D004008:Diclofenac / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004386:Duodenum / Q000187:drug effects; D004487:Edema / Q000188:drug therapy; D005260:Female; D066298:In Vitro Techniques; D051379:Mice; D011465:Prostaglandins, Synthetic / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy; D014590:Uterine Contraction / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D011465:Prostaglandins, Synthetic; D004008:Diclofenac
Farmakologicheskaia aktivnost' sinteticheskikh analogov prostaglandinov.