[Significance of lipids in the diagnosis of coronary heart disease in patient groups and individuals].
Several epidemiologic studies confirmed the significance of the risk ratio cholesterol/HDL-cholesterol in predicting coronary heart disease. Therefore we examined the lipid values of 364 men and 133 females who underwent coronary arteriography because of angina pectoris and/or pathological ECG changes at rest or during exercise stress testing. Although patients with coronary heart disease showed higher cholesterol (male 238 mg/dl vs. 210 mg/dl, female 251 mg/dl vs. 219 mg/dl, p less than 0.001), higher triglycerides (male 204 mg/dl vs. 162 mg/dl, female 179 mg/dl vs. 125 mg/dl, p less than 0.001) and significantly lower HDL-cholesterol levels (male 39.9 mg/dl vs. 44 mg/dl, female 45.9 mg/dl vs. 54.9 mg/dl, p less than 0.01) than the control group, lipid values did not lead to a good discrimination between patients with or without coronary heart disease. The patients' histories and ECGs showed a higher sensitivity (male 83%/male 85%) and specificity (male 81%/female 83%) than the lipids (sensitivity male 57%/female 67%, specificity male 55%/female 74%). We conclude from our results that blood lipids, the risk ratio cholesterol/HDL-cholesterol and other risk factors are diagnostic tools which have to be handled with caution when applied to the individual patient with suspected coronary heart disease.
D000787:Angina Pectoris / Q000175:diagnosis; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012306:Risk; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol
Bedeutung der Lipide in der Diagnostik der koronaren Herzkrankheit bei Patientengruppen und Einzelpersonen.