title: Therapeutic safety studies of brotizolam in animals.
abstract: Comparing dose levels for pentetrazol antagonism or antiaggressive activity with those causing motorial side effects in mice brotizolam (2-bromo-4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f]-1,2,4-triazolo [4,3-alpha]-1,4-diazepine, We 941, Lendormin) showed consistently larger dose ranges than diazepam. This gives evidence that brotizolam may offer the advantage of not causing motorial side effects during therapeutic use as do many other diazepines.
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D001381:Azepines / Q000633:toxicity*; D003975:Diazepam / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011597:Psychomotor Performance / Q000187:drug effects
chemical_list: D001381:Azepines; D006993:Hypnotics and Sedatives; C020960:brotizolam; D003975:Diazepam; D010433:Pentylenetetrazole