Presence of an endothelial antigen on the syncytiotrophoblast of human chorionic villi: detection by a monoclonal antibody.
We describe a monoclonal antibody, B721. This antibody reacts with an antigen present on vascular endothelium and on the syncytiotrophoblast of term chorionic villi. The antigen is absent from the trophoblast of the chorion, from the amniotic epithelium, and from normal peripheral blood or lymph node lymphocytes. We discuss the possible functional roles of the antigen. We propose that the syncytiotrophoblast, by expressing endothelial antigens, mimics endothelium and may perform endothelial functions.
D000328:Adult; D000911:Antibodies, Monoclonal; D000941:Antigens / Q000302:isolation & purification*; D002460:Cell Line; D002824:Chorionic Villi / Q000276:immunology*; D004727:Endothelium / Q000276:immunology; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008833:Microcirculation / Q000276:immunology; D009131:Muscle, Smooth, Vascular / Q000276:immunology; D009928:Organ Specificity; D011247:Pregnancy; D014327:Trophoblasts / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000941:Antigens