Effects of free fatty acids and L-carnitine on the spontaneous motility of rat isolated uterine horn.
In the present investigation the effects of free fatty acids (FFA) and L-carnitine were investigated on the rat isolated uterine horn. The cumulative addition of FFA and L-carnitine to the isolated organ bath produced a significant increase of isometric developed tension and functional activity, especially evident at 5 mM carnitine concentration. No variations in the frequency of contractions were found. These data suggest a possible role of FFA as energy source in the rat uterus.
D000818:Animals; D002331:Carnitine / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects / Q000502:physiology*
D005230:Fatty Acids, Nonesterified; D002331:Carnitine