Effect of digoxin on human erythrocyte glucose-6-phosphate dehydrogenase activity. A link to natriuretic hormone?
The authors studied the effect of a 0.5 mg intravenous bolus injection of digoxin on human red blood cell glucose-6-phosphate activity under in vivo circumstances. Digoxin administration resulted in a small but statistically significant rise in the enzyme activity. This effect of digoxin seems to support the hypothesis that the circulating sodium transport inhibitor substance or natriuretic hormone found in a group of patients with essential hypertension may be an endogenous digitalis because the two substances act similarly in this respect.
D000328:Adult; D004077:Digoxin / Q000494:pharmacology*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D045283:Natriuretic Agents / Q000502:physiology*
D045283:Natriuretic Agents; D004077:Digoxin; D005954:Glucosephosphate Dehydrogenase