title: [Sickle cell anemia and its skeletal and joint changes as an orthopedic problem].
abstract: In more than 15% of the homozygotic patients sickle-cell anemia coincides with severe changes of the skeleton. The skeletal manifestation of the disease is characterized by a generalized osteoporosis and--more typical--by destruction of the epi- and metaphysis caused by osseous infarction. The indication, effectiveness and technical problems of total joint replacement in bilateral destruction of the hipjoints due to sickle-cell anemia are demonstrated.
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D001847:Bone Diseases / Q000209:etiology*; D005271:Femur Head Necrosis / Q000209:etiology / Q000601:surgery; D006622:Hip Prosthesis; D006801:Humans; D007592:Joint Diseases / Q000209:etiology*; D008297:Male; D010014:Osteolysis / Q000209:etiology; D010020:Osteonecrosis / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology
vernacular_title: Die Sichelzellanämie und ihre Skelett- bzw. Gelenkveränderungen als orthopädisches Problem.