Hyperthermia induced by open-field stress is blocked by salicylate.
Psychological stress results in a rise in body temperature. Here we report that in rats, hyperthermia induced by open-field stress can be blocked by administration of the antipyretic drug sodium salicylate. These data suggest that this rise in body temperature is a true fever, perhaps mediated by prostaglandins.
D000818:Animals; D005334:Fever / Q000503:physiopathology / Q000517:prevention & control / Q000523:psychology*; D008297:Male; D009270:Naloxone; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012980:Sodium Salicylate / Q000494:pharmacology*; D013315:Stress, Psychological / Q000150:complications*
D011453:Prostaglandins; D009270:Naloxone; D012980:Sodium Salicylate