Malignancy-associated cellular markers (MAC) in oral and bronchial epithelial cells in sputum specimens: possible morphologic marker for high-risk groups (asbestos-exposed workers).
To verify a possible role of malignancy-associated cellular markers (MAC) in high-risk groups, the authors reviewed a total of 291 consecutive sputum specimens from 97 workers exposed to asbestos. The asbestos workers were matched according to smoking habits and cellular changes. Twelve subjects (12.3%) had MAC in epithelial cells; eight were smokers, four nonsmokers. Among MAC+ smokers, three sputum specimens contained cells of squamous metaplasia and one had cells from carcinoma in situ. Two MAC+ nonsmokers had cells of squamous metaplasia, too. In addition, MAC+ cells were also identified in four inflammatory samples, belonging either to smokers or nonsmokers. Two MAC+ subjects had a negative sputum specimen. In keeping with these results, the authors believe that MAC evaluation in sputum specimens might be of help in the oncologic follow-up of asbestos-exposed workers.
D000395:Air Pollutants, Occupational / Q000009:adverse effects; D001194:Asbestos / Q000009:adverse effects*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D012306:Risk; D013183:Sputum / Q000473:pathology*
D000395:Air Pollutants, Occupational; D001194:Asbestos