title: Variations of glucocorticoid receptors in intact or denervated muscles: lack of cause-effect relationship with muscle atrophy in the rat.
abstract: The process of muscular atrophy following denervation has been tentatively ascribed to the influence of glucocorticoids (G) because of the rapid increase of cytosolic G receptors (RG) after sciatic nerve section. It appears however that the level of muscular atrophy is similar: in slow or fast-twitch muscles in spite of huge variations in RG; in intact or adrenalectomized (ADR-X) rats. Moreover, the protein muscle profile of intact of ADR-X rats after gel electrophoresis is similar but drastically decreased after 3 weeks of denervation. We conclude that there is no cause-effect relationship between muscle atrophy and RG elevation after nerve section.
mesh_terms: D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D003600:Cytosol / Q000378:metabolism; D005260:Female; D009121:Muscle Denervation; D009124:Muscle Proteins / Q000378:metabolism; D009132:Muscles / Q000033:anatomy & histology / Q000294:innervation / Q000378:metabolism*; D009133:Muscular Atrophy / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000378:metabolism*
chemical_list: D009124:Muscle Proteins; D011965:Receptors, Glucocorticoid