Sensitivity to non-acetylated salicylates in a patient with asthma, nasal polyps, and rheumatoid arthritis.
A woman experienced exacerbations of bronchial asthma after taking aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) for rheumatoid arthritis. On oral challenges, she developed an urticarial reaction after tartrazine; urticarial and bronchospastic reactions after salicylsalicylic acid; and urticarial and bronchospastic reactions after choline magnesium trisalicylate. Non-acetylated salicylates have been recommended for use in aspirin- and/or tartrazine-sensitive patients. The results of sensitivity studies of our patient indicates that such patients may also be sensitive to non-acetylated salicylates.
D000420:Albuterol / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001249:Asthma / Q000188:drug therapy*; D001986:Bronchial Spasm / Q000139:chemically induced / Q000188:drug therapy; D002794:Choline / Q000009:adverse effects / Q000031:analogs & derivatives; D004338:Drug Combinations / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009298:Nasal Polyps / Q000188:drug therapy*; D012459:Salicylates / Q000009:adverse effects*; D013645:Tartrazine / Q000009:adverse effects; D014581:Urticaria / Q000139:chemically induced
D004338:Drug Combinations; D012459:Salicylates; D013645:Tartrazine; C015075:choline salicylate; D002794:Choline; D000420:Albuterol; C014182:salicylsalicylic acid