Chronic liver disease associated with high hepatic copper concentration in a dog.
An 8-month-old dog admitted for routine castration was found to have ascites. Liver biopsy revealed inflammation, fibrosis, and a copper concentration of 1,300 ppm on a dry weight basis. As cirrhosis developed, the copper concentration decreased without chelator treatment. At necropsy, the dog had cirrhosis, but the hepatic copper concentration was only 730 ppm.
D000818:Animals; D001706:Biopsy; D002908:Chronic Disease; D003300:Copper / Q000378:metabolism*; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D008099:Liver / Q000032:analysis*; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D008297:Male
D003300:Copper