Acute effects of sex steroids on lordosis behaviour of the female rat.
In the present series of experiments, dose-response and time-response relationships between single injections of sex steroids and the display of lordosis behaviour in the female rat, were investigated. When injected 48 h prior to testing, increasing doses of estradiol benzoate (EB) or testosterone propionate (TP) resulted in increasing levels of lordosis behaviour. TP was much less effective than EB in facilitating lordosis behaviour in the female rat. The optimum time interval between hormonal treatment and testing was 48-72 h for TP, but 48 h for EB. Single injections of dihydrotestosterone propionate (DHTP), also injected 48 h prior to testing, inhibited lordosis behaviour in EB-primed female rats. DHTP-inhibition of lordosis behaviour in EB-primed female rats was most effective when given prior to and least effective when given after EB-treatment. Progesterone, injected 4 h prior to testing, facilitated lordosis in EB-, TP- or EB + DHTP-treated female rats.
D000818:Animals; D013196:Dihydrotestosterone / Q000031:analogs & derivatives / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D011187:Posture; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology; D013997:Time Factors
D012739:Gonadal Steroid Hormones; D013196:Dihydrotestosterone; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; C030445:dihydrotestosterone propionate