[Clinical experience with thymostimulin (TP-1) therapy. Preliminary findings].
In order to verify the immunostimulant effect of thymus humoral factors, a bovine thymic extract (TP 1-Thymostimulin) was given to 9 patients affected by primary immunodeficiency (mild deficit T/B combined) and to 8 patients affected by acquired immunodeficiency because of old age, lung neoplasm or with recurrent herpes simplex labialis. 6 patients affected by chronic hepatitis HBsAg+ and 1 patient affected by Behçet's syndrome were also studied. At the end of the study, after six months, all the patients with primary or acquired immunodeficiency showed a normalization of their immunological parameters and a clinical improvement. A clinical improvement was also observed in the patients affected by lung neoplasm. Instead, patients suffering from chronic active hepatitis HBsAg+ showed unsatisfactory results; the study did not reveal any clinical or immunological improvement in these cases. The patient affected by Behçet's syndrome showed a decreased recurrent uveitis.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D001528:Behcet Syndrome / Q000188:drug therapy / Q000276:immunology; D002648:Child; D003165:Complement System Proteins / Q000032:analysis; D006521:Hepatitis, Chronic / Q000188:drug therapy / Q000276:immunology; D006561:Herpes Simplex / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy / Q000276:immunology; D008175:Lung Neoplasms / Q000188:drug therapy / Q000276:immunology; D008875:Middle Aged; D012008:Recurrence; D013949:Thymus Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000276:immunology; D014605:Uveitis / Q000188:drug therapy / Q000276:immunology
D000276:Adjuvants, Immunologic; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D013949:Thymus Extracts; C031407:thymostimulin; D003165:Complement System Proteins
Esperienza clinica di terapia con timostimolina (TP 1). Osservazioni preliminari.