Evaluation of the effect of glucan on hepatic, renal and mammary tumorigenesis in rats.
Glucan was evaluated for its ability to modify the hepatic and renal tumorigenesis induced in partially hepatectomized Sprague-Dawley female rats by diethylnitrosamine (DEN) and phenobarbital (PB), and the mammary tumorigenesis induced in intact Sprague-Dawley female rats by N-nitrosomethylurea (NMU). In both models the rats received every two weeks i.v. glucan (10 mg/kg) or equivalent amounts of dextrose. The results indicated that glucan did not significantly modify the incidence of the chemically-induced hepatic, renal and mammary tumors.
D000818:Animals; D004052:Diethylnitrosamine; D005260:Female; D005936:Glucans / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D006498:Hepatectomy; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D008325:Mammary Neoplasms, Experimental / Q000473:pathology* / Q000517:prevention & control; D008770:Methylnitrosourea; D010634:Phenobarbital; D051381:Rats; D011919:Rats, Inbred Strains
D005936:Glucans; D004052:Diethylnitrosamine; D008770:Methylnitrosourea; D005947:Glucose; D010634:Phenobarbital