title: No significant net uptake of branched chain amino acids by the liver of fed-mid pregnant rats.
abstract: The hepatic balance for valine, leucine and isoleucine has been measured in anaesthetized virgin controls and 9 and 12-day pregnant rats. The liver of non gravid animals show fractional extraction rates of over 11.6% for valine, 17.6% for leucine and 16.8% for isoleucine. Fed mid-pregnant rats do not show either a significant net uptake nor a release of these amino acids. It is proposed that higher intestinal amino acid requirements for protein synthesis during mid pregnancy than before impregnation may be, in part, the cause of a decreased hepatic uptake and, thus, a different role for the liver in the amino acid inter-organ relationships during this period is suggested.
mesh_terms: D000597:Amino Acids, Branched-Chain / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D005260:Female; D007532:Isoleucine / Q000378:metabolism; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011919:Rats, Inbred Strains; D014633:Valine / Q000378:metabolism
chemical_list: D000597:Amino Acids, Branched-Chain; D007532:Isoleucine; D007930:Leucine; D014633:Valine