Effect of 3-amino-1,2,4-triazole pretreatment on ethanol blood levels after intraperitoneal administration.
Aminotriazole (1 g/kg IP) pretreatment resulted in higher ethanol blood levels during the first hour after 90 mmole/kg IP ethanol administration and at 1 hour after when rats received 60 mmole/kg IP, than the respective controls receiving the same doses of ethanol. No difference in the blood levels at time higher than 1 hour were observed, in spite of the fact that the inhibitory effect of aminotriazole lasted more than 7 hours. These results are consistent with the idea that hepatic catalase may play a significant role in liver first pass effect when portal blood levels are expected to be rather high, but not when distribution balance is established.
D000640:Amitrole / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002374:Catalase / Q000378:metabolism; D000431:Ethanol / Q000097:blood*; D005260:Female; D007274:Injections, Intraperitoneal; D008099:Liver / Q000201:enzymology; D008297:Male; D051381:Rats; D014230:Triazoles / Q000494:pharmacology*
D014230:Triazoles; D000431:Ethanol; D002374:Catalase; D000640:Amitrole