Echocardiographic evaluation of inferior vena cava wall motion and pulmonary flow velocity responses to sublingual nifedipine.
Echocardiographic and cardiac catheterization were used to test the effect of Nifedipine, sublingually administered, on the right heart function and pulmonary flow velocity and pressure in 25 cases. Systolic and mean pulmonary pressure, wedge pressure, mean right atrial and ventricular end-diastolic pressure, aortic pressure, and total pulmonary resistance decreased after Nifedipine in 10 patients who underwent diagnostic cardiac catheterization. While pulmonary flow velocity, expressed as the slope of the contrast echo lines on the pulmonary valve, increased as a mean value after Nifedipine, it showed different behaviour in single cases and thus failed to provide any reliable conclusion as to the effect of Nifedipine. Nifedipine slightly reduced the internal diameters of the inferior vena cava and significantly increased the values of collapsibility and emptying indexes and pulsation. The results confirm the beneficial effect of Nifedipine on right heart function and pulmonary bed. In addition, echocardiography is seen to be a valuable and reliable non-invasive means of testing the acute and chronic effects of either Nifedipine or other drugs on the right heart sections.
D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D006328:Cardiac Catheterization; D004452:Echocardiography; D005260:Female; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D011652:Pulmonary Circulation / Q000187:drug effects; D011664:Pulmonary Valve / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D014682:Vena Cava, Inferior / Q000187:drug effects
D009543:Nifedipine