[Circulating immune complex (CIC) and antitumor antibody in the serum of rats with thyroid carcinoma induced by 132I].
The antibody against thyroid cancer in serum of 29 rats was tested by indirect immunofluorescent technique and CIC levels were determined by polyethylene glycol (PEG) precipitation during the process of thyroid cancer being induced by 132I. The results showed that the antibody against thyroid cancer is not observed and CIC levels are significantly higher in groups with induced thyroid cancer (0.0316 +/- 0.0072), degeneration and focal epithelial proliferation (0.0211 +/- 0.0107) than that of the normal control group (0.0126 +/- 0.0066) (P less than 0.001). The CIC levels are gradually increased as the thyroid histopathology changes from degeneration and focal epithelial proliferation, benign tumor to malignancy. The causes of CIC increase and their significance are discussed.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000032:analysis*; D000936:Antigen-Antibody Complex / Q000032:analysis*; D006965:Hyperplasia / Q000276:immunology; D007457:Iodine Radioisotopes; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D013964:Thyroid Neoplasms / Q000276:immunology*
D000912:Antibodies, Neoplasm; D000936:Antigen-Antibody Complex; D007457:Iodine Radioisotopes