Further studies on the therapeutic effect of indomethacin on esophageal tumors.
The effect of treatment with the nonsteroid anti-inflammatory drug indomethacin, was investigated in 250 3-month-old C57Bl female mice following induction of esophageal tumors with diethylnitrosamine (DEN). Already 3 months after DEN treatment, many esophageal tumors were committed to occur: despite discontinued DEN treatment, the number of tumors had increased significantly at 6 or 9 months of observation. Following 3 and 4 months of DEN administration, the development of many already committed esophageal tumors was significantly abrogated by treating the mice with indomethacin.
D000818:Animals; D004052:Diethylnitrosamine; D004938:Esophageal Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D007213:Indomethacin / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL
D004052:Diethylnitrosamine; D007213:Indomethacin