[Structure-release relationship of physical polymer/drug combinations. 2. Diffusion of 3-methylpyrazole through a synthetic polymer matrix].
The diffusion of 3-methylpyrazole through a synthetic polymer matrix and the effect of the solubility of the bioactive agent in polymers on the release behaviour of polymer combinations were studied. With increasing hydrophilicity of the polymer both the diffusion and the diffusion coefficient of 3-methylpyrazole increased and the solubility of the agent in the polymer decreased. The hydrophilicity of various polymers is discussed on the basis of a parameter determined by turbidimetric titrations.
D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D004058:Diffusion; D009391:Nephelometry and Turbidimetry; D011108:Polymers; D011720:Pyrazoles / Q000032:analysis*; D013329:Structure-Activity Relationship
D011108:Polymers; D011720:Pyrazoles; C047114:3-methylpyrazole
Struktur-Freisetzungs-Beziehungen physikalischer Polymer/Wirkstoff-Kombinationen. 2. Mitteilung: Zur Diffusion von 3-Methylpyrazol durch synthetische Polymermatrices.