Spontaneous alternation and habituation in a t-maze in nervous mutant mice.
Nervous mutant mice have a selective degeneration of Purkinje cells and deep cerebellar nuclei. In comparison with littermate controls, nervous mutant mice did not alternate spontaneously in a successive trial procedure (six consecutive trials per day) and did not habituate in a restricted part of a t-maze in a 4-min session. These data indicate that the cerebellum may have a role in spatial learning.
D000818:Animals; D001931:Brain Mapping; D002531:Cerebellum / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D007858:Learning / Q000502:physiology*; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants; D009043:Motor Activity / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D013028:Space Perception / Q000502:physiology