Marginal metallophilic cells of the mouse spleen identified by a monoclonal antibody.
A monoclonal antibody, MOMA-1, is described that recognizes the marginal metallophilic macrophages in the mouse spleen. The cells are localized at the marginal sinus forming a ring around the periarteriolar lymphocyte sheath and follicular areas at the inner side of the marginal zone. They show high non-specific esterase activity and can be distinguished from the marginal zone macrophages by antibody staining and the lack of FITC-Ficoll uptake. The relationship of MOMA-1-positive cells with other macrophage populations is discussed.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D007421:Intestine, Small / Q000166:cytology; D008198:Lymph Nodes / Q000166:cytology; D008264:Macrophages / Q000201:enzymology / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000166:cytology* / Q000201:enzymology
D000911:Antibodies, Monoclonal; D002265:Carboxylic Ester Hydrolases; D000135:Acid Phosphatase