Nonantral gastric carcinoid tumours associated with hypergastrinaemia.
Nonantral gastric carcinoid tumours in association with pronounced hypergastrinaemia are reported in 6 patients. It is suggested that the hypergastrinaemia, as a result of lack of a negative acid feedback inhibition in an achlorhydric stomach, promoted the tumour development, possibly initiated by action of carcinogenic nitrosamines, in the gastric juice.
D000328:Adult; D000368:Aged; D002276:Carcinoid Tumor / Q000097:blood* / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000097:blood* / Q000473:pathology
D005755:Gastrins