Spinal cord decompression sickness: a comparison of recompression therapies in an animal model.
Somatosensory evoked potentials (SEP) were used in an animal model to measure spinal cord electrophysiological function. Animals were submitted to a dive profile resulting in spinal cord decompression sickness (DCS). The animals were treated after a delay allowing the lesion to consolidate. Serial measurements of SEP documented the onset, duration, and outcome of treatment. Physiological data were recorded throughout each experiment. Group A (n = 10) was recompressed to 60 fsw (feet of sea water) breathing 100% oxygen (2.8 ATA) and Group B (n = 8) was treated at 66 fsw breathing 66% oxygen (2.0 ATA). No differences were found between groups in the severity, surface interval before treatment, or the maximum effect of treatment. The maximum effect of treatment was seen by 25 min of treatment. Animals were regrouped into responders and nonresponders. The latter displayed a more rapid onset, a more severe insult, and more adverse physiological effects than the responders. The possibility of a different etiology was considered together with the failure to differentiate between the treatment groups. It was concluded that treatment B was safer but the problems of introducing a new therapeutic table outweighed the safety advantage.
D000818:Animals; D003664:Decompression; D003665:Decompression Sickness / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D004285:Dogs; D005073:Evoked Potentials, Somatosensory; D006931:Hyperbaric Oxygenation; D008297:Male; D013116:Spinal Cord / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*