QSAR in a series of muscarinic agents. Note VI. Five-membered cyclic ligands.
Proceeding in our study on the muscarinic receptor site, a refinement of its topology by means of Quantitative Structure-Activity Relationships has been carried out. Specific key structures have been selected considering not only muscarine and the corresponding desether derivative, but also a set of cyclopentenyltrimethylammoniummethyl salts. These derivatives, considered in a correlation equation extended to all of the five-membered cyclic structures previously examined, significantly improve understanding of contributions of critical ligand substructures to the overall interaction. The results obtained reinforce the reliability of correlation equations in structure-activity studies.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008024:Ligands; D009116:Muscarine / Q000494:pharmacology; D010277:Parasympathomimetics / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D008024:Ligands; D010277:Parasympathomimetics; D009116:Muscarine