In vitro inactivation of aminoglycosides by apalcillin.
Apalcillin, at concentrations of 75, 150, 300, and 600 micrograms/ml, was combined in vitro with amikacin, gentamicin, netilmicin, or tobramycin. Incubation at 37 degrees C resulted in an apalcillin concentration-dependent and time-dependent decrease of aminoglycoside activity of up to 60%. Amikacin was the most stable and tobramycin was the least stable aminoglycoside under the conditions tested.
D000583:Amikacin / Q000037:antagonists & inhibitors*; D000667:Ampicillin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004338:Drug Combinations; D004355:Drug Stability; D005839:Gentamicins / Q000037:antagonists & inhibitors*; D007612:Kanamycin / Q000031:analogs & derivatives*; D009287:Naphthyridines; D009428:Netilmicin / Q000037:antagonists & inhibitors*; D013997:Time Factors; D014031:Tobramycin / Q000037:antagonists & inhibitors*
D004338:Drug Combinations; D005839:Gentamicins; D009287:Naphthyridines; C012122:apalcillin; D009428:Netilmicin; D007612:Kanamycin; D000667:Ampicillin; D000583:Amikacin; D014031:Tobramycin