Solitary extranodal lymphoma of sciatic nerve.
A solitary extranodal malignant lymphoma (non-Hodgkin's lymphoma, centrocytic type) of the sciatic nerve is described in a 64-year-old woman. Whereas previous reports of peripheral nervous system lymphoma have described multifocal lesions and generally an association with systemic lymphomas, in this case the lymphoma was confined to a segment of a peripheral nerve and was not associated with systemic lymphoma. The clinical presentation was a progressive weakness and sensory disturbance in the right leg. Clinical and electrophysiological examination indicated a lesion in the sciatic nerve, and computerised tomography of the right thigh revealed an enlarged distal segment of the sciatic nerve. On surgical exploration, a fusiform tumour of the sciatic nerve was resected. Pathological examination, including immunohistology and electron microscopy revealed a malignant lymphoma. An unusual histological feature was the presence in the tumour and infiltrated nerve of an extracellular eosinophilic non-amyloid material, similar to that occasionally seen in nodal lymphomas. The patient showed no evidence of lymphoma at other sites at the presentation and this has been confirmed at a 9-month review.
D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008223:Lymphoma / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D008875:Middle Aged; D009431:Neural Conduction; D010524:Peripheral Nervous System Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed