The prognostic significance of the DNA distribution in squamous-cell carcinomas of the uterine cervix.
To establish the prognostic parameters of DNA distributions of squamous-cell carcinomas of the uterine cervix, cervical smears from 30 patients were examined cytomorphometrically ten years after the diagnosis had been made. Most of the patients had stage II cervical carcinomas that had been treated with primary combined irradiation. In the DNA histograms, the position of the stemline proved to be the prognostically significant factor. All of the patients with diploid or euploid-polyploid stemlines were still alive after ten years while only 17.6% of those with aneuploid stemlines have survived. No correlation between the ten-year survival rate and the proliferation rate of the tumors could be established.
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000032:analysis* / Q000145:classification / Q000473:pathology; D002455:Cell Division; D003592:Cytophotometry; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011003:Ploidies; D011184:Postoperative Period; D011379:Prognosis; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000032:analysis* / Q000145:classification / Q000473:pathology
D004273:DNA, Neoplasm