[Comparative study of the antimutagenic activity of diphenols].
Comparative study of the ability of three diphenols (pyrocathechol, resorcinol and hydroquinone) to inhibit the mutagenic activity of benzo(a)pyrene was carried out using the test for micronuclei account in mice polychromatic erythrocytes. It was suggested that the antimutagenic activity of diphenols used is mostly due to isomeric effect, i.e. the position of hydroxy-groups in molecules of diphenols.
D000818:Animals; D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors; D001853:Bone Marrow / Q000648:ultrastructure; D002396:Catechols / Q000494:pharmacology; D002467:Cell Nucleus / Q000648:ultrastructure; D002869:Chromosome Aberrations / Q000187:drug effects*; D006873:Hydroquinones / Q000494:pharmacology; D051379:Mice; D009153:Mutagens; D009154:Mutation; D010636:Phenols / Q000494:pharmacology*; D012118:Resorcinols / Q000494:pharmacology; D013329:Structure-Activity Relationship
D002396:Catechols; D006873:Hydroquinones; D009153:Mutagens; D010636:Phenols; D012118:Resorcinols; D001564:Benzo(a)pyrene
Sravnitel'noe izuchenie antimutagennoĭ aktivnosti difenolov.