Pharmacokinetic and pharmacodynamic evaluation of gelatin microcapsule containing piretanide in beagle dogs.
A sustained-release property of gelatin microcapsules of piretanide was evaluated by pharmacodynamic parameters. The gelatin microcapsules of piretanide showed long-lasting, slow-release properties, when compared with its ordinary tablet form in the plasma piretanide level, piretanide excretion rate, urine excretion rate and urinary electrolyte (Na+, K+, Cl-) excretion rate without any loss in diuretic and saluretic activities, which fully satisfied the criteria for a sustained-release preparation.
D000284:Administration, Oral; D000818:Animals; D002214:Capsules; D002712:Chlorides / Q000652:urine; D004285:Dogs; D005780:Gelatin; D007700:Kinetics; D008297:Male; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D013449:Sulfonamides / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology
D002214:Capsules; D002712:Chlorides; D013449:Sulfonamides; D005780:Gelatin; D012964:Sodium; C015451:piretanide; D011188:Potassium