[Reinforcing, but no analgesic, effect of opioid stimulation of the ventral tegmental area].
Analgesic and secondary reinforcing effects of morphine, bremazocine and phencyclidine microinjections into ventral tegmental area were studied in rats. The drugs under study failed to affect nociceptive reactions produced by thermal, mechanic and electrical stimuli. Morphine and phencyclidine have shown reinforcing properties in place preference paradigm. Ventral tegmental area seems to be a triggering zone of the reinforcing, and not analgesic effect of opioid agonists, with an important role of mu- and sigma-receptors revealed.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001575:Benzomorphans / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology; D010622:Phencyclidine / Q000494:pharmacology; D051381:Rats; D012054:Reinforcement, Psychology; D013681:Tegmentum Mesencephali / Q000187:drug effects*
D000700:Analgesics; D001575:Benzomorphans; D009020:Morphine; C027248:bremazocine; D010622:Phencyclidine
Podkrepliaiushchee, no ne anal'geticheskoe deĭstvie opioidnoĭ stimuliatsii ventral'noĭ tegmental'noĭ oblasti.