title: Pharmacological effects of oral saikosaponin a may differ depending on conditions of the gastrointestinal tract.
abstract: Saikosaponin a and its 8 derivatives, structural isomers and their monoglycosides and aglycones, which were formed in the gastrointestinal tract with their fecal contents depending on food intake, showed different effects on protein synthesis by rat hepatocytes in primary culture. Saikosaponin a and its monoglycoside and aglycone were detectable in plasma of rats when saikosaponin a was orally administered. Pharmacological effects of saikosaponin a when orally administered may differ depending on conditions of the gastrointestinal tract.
mesh_terms: D000818:Animals; D007408:Intestinal Absorption; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D014176:Protein Biosynthesis; D051381:Rats; D012502:Sapogenins / Q000378:metabolism / Q000494:pharmacology*; D012503:Saponins
chemical_list: D012502:Sapogenins; D012503:Saponins; D009828:Oleanolic Acid; C025759:saikosaponin D