Autonomic dysreflexia in a paraplegic man with catecholamine-secreting neuroblastoma.
Autonomic dysreflexia and catecholamine secreting tumor, each of which causes paroxysmal hypertension, coexisted in a young man. Two years after neuroblastoma was diagnosed, he developed T4 incomplete paraplegia due to metastases to the spine at T5 and L3 levels. Shortly after the onset of paraplegia, paroxysmal hypertension developed. The hypertension was controlled adequately by good bowel and bladder management and oral clonidine. The paroxysmal hypertension is believed to have resulted from the synergistic effect of the high levels of circulating catecholamines from the tumor and the disruption of autonomic pathways.
D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000209:etiology*; D002395:Catecholamines / Q000378:metabolism*; D003000:Clonidine / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D008297:Male; D009447:Neuroblastoma / Q000150:complications / Q000378:metabolism*; D010264:Paraplegia / Q000150:complications*; D012021:Reflex, Abnormal / Q000209:etiology*; D013125:Spinal Neoplasms / Q000378:metabolism*
D002395:Catecholamines; D003000:Clonidine