Biotransformation of trans-sobrerol. III. Metabolites of 8-hydroxycarvotanacetone in the rat.
The metabolism of 8-hydroxycarvotanacetone (HCA), a major metabolite of trans-sobrerol, was studied in female rats after a single oral dose. The metabolic pathways include hydroxylation, reduction to cis- and trans-sobrerol, glucuronylation and Michael addition with glutathione giving rise to mercapturic acids which then undergo reduction. Biological reduction appears to occur more readily for the alicyclic-saturated ketones (Michael adducts) than for the alpha, beta unsaturated ketones (HCA and hydroxylated metabolites). This is in agreement with the chemical reactivity of the compounds.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002849:Chromatography, Gas; D005260:Female; D005978:Glutathione / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013729:Terpenes / Q000378:metabolism* / Q000652:urine
D013729:Terpenes; C049018:8-hydroxycarvotanacetone; C003316:sobrerol; D005978:Glutathione