title: Special studies of the Hickman catheter of a patient with recurrent bacteremia and candidemia.
abstract: A patient with acute non-lymphocytic leukemia developed Staphylococcus epidermidis bacteremia and candidemia after maintenance chemotherapy and was treated satisfactorily. He returned 3 months later with abdominal pain due to an abdominal aortic aneurysm. At laparotomy, the aneurysm was found to be infected with Candida albicans. Following surgery, repeated positive blood cultures for C. albicans led to removal of his Hickman catheter. Culture of the catheter tip yielded C. albicans and S. epidermidis. Study of the catheter by scanning and transmission electron microscopy demonstrated yeast-like cells and gram-positive cocci in a biofilm. These studies suggest that the Hickman catheter was the source of the persistent candidemia and that it may have been the origin of the infection of the aneurysm.
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D001012:Aorta, Abdominal; D001014:Aortic Aneurysm / Q000382:microbiology; D002177:Candidiasis / Q000209:etiology*; D002408:Catheters, Indwelling / Q000009:adverse effects*; D004866:Equipment Contamination; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D018805:Sepsis / Q000209:etiology*; D013203:Staphylococcal Infections / Q000209:etiology*; D013212:Staphylococcus epidermidis; D014680:Veins
chemical_list: D000970:Antineoplastic Agents