Impact of cefaclor on the pharmacokinetics of theophylline.
The influence of cefaclor taken for 8 days (250 mg every 8 h) on the pharmacokinetics of a single intravenous dose of theophylline (2 mg/kg administered on the 8th cefaclor day) was studied in a crossover fashion among 11 healthy adults (10 men and one woman). Theophylline concentrations were measured serially for 12 h by an immunofluorescence polarization technique. No influence of cefaclor was detectable on theophylline clearance, half-life, or volume of distribution. It is concluded that cefaclor and theophylline can be administered together safely.
D000328:Adult; D002433:Cefaclor / Q000009:adverse effects / Q000494:pharmacology*; D002506:Cephalexin / Q000031:analogs & derivatives*; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D013806:Theophylline / Q000009:adverse effects / Q000378:metabolism*
D002433:Cefaclor; D013806:Theophylline; D002506:Cephalexin