Controlled trial of rice powder and glucose rehydration solutions as oral therapy for acute dehydrating diarrhea in infants.
A controlled, randomized trial was conducted in 50 infants (3 to 18 months old) hospitalized with acute noncholera dehydrating diarrhea to compare the safety, efficacy, and acceptability of the standard World Health Organization (WHO) recommended glucose oral rehydration solution (ORS) (Group A: 25 infants) with that of a rice powder ORS (Group B: 25 infants), containing 30 g/L of rice powder instead of glucose (20 g/L). The electrolyte composition of both solutions was identical. The proportion of successfully treated patients in each group was 92%, and the two rehydrating solutions proved comparable in correcting and maintaining the hydration status and the serum sodium and potassium levels. The mean rehydration time, stool output, stool frequency, ORS intake, weight gain, and urine output were comparable (p greater than 0.05) in both groups. It is concluded that rice powder ORS is safe, effective, and acceptable as the standard WHO glucose ORS for the treatment of acute noncholera dehydrating diarrhea in infants.
D000138:Acidosis / Q000628:therapy; D003681:Dehydration / Q000628:therapy; D003968:Diarrhea, Infantile / Q000628:therapy*; D005440:Fluid Therapy; D005947:Glucose / Q000627:therapeutic use*; D006801:Humans; D006955:Hypernatremia / Q000628:therapy; D007008:Hypokalemia / Q000628:therapy; D007010:Hyponatremia / Q000628:therapy; D007223:Infant; D008297:Male; D012275:Oryza; D011208:Powders; D011897:Random Allocation
D011208:Powders; D005947:Glucose