Studies on tableting properties of lactose. Part III. The consolidation behaviour of sieve fractions of crystalline alpha-lactose monohydrate.
The consolidation and compaction behaviour of sieve fractions of crystalline alpha-lactose monohydrate were studied. From mercury porosimetry measurements tablet pore surface areas were derived. At a certain compaction load it appeared that tablets compressed from small particles were generally stronger and showed a larger surface area than compacts prepared from coarse sieve fractions. By plotting compact strength against pore surface area, a unique linear relationship was obtained. From these results it can be concluded that the actual tablet surface area, being a function of both the initial particle size and applied compaction pressure, is responsible for the compact strength.
D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D004339:Drug Compounding; D005079:Excipients; D007785:Lactose / Q000032:analysis*; D013499:Surface Properties; D013607:Tablets
D005079:Excipients; D013607:Tablets; D007785:Lactose