title: Effect of saline infusion on net reabsorption of endogenous sulfate relative to that of phosphate in intact and thyroparathyroidectomized rats.
abstract: Clearance experiments have been performed to study the effects of saline infusion on the reabsorption of inorganic sulfate (SO4) at endogenous levels. Adult female Sprague-Dawley rats on a standard diet were used. Both intact and thyroparathyroidectomized (TPTX) animals were infused with a 130 mmol/l sodium chloride solution at a low (0.15 ml/min) and a high (0.375 ml/min) rate. This increase of the infusion rate decreased the reabsorption of SO4 in both groups of animals significantly. The fractional excretion of SO4 in the intact rats increased from 9.9 +/- 5.6 to 18.4 +/- 3.6% (mean values +/- SD, p less than 0.001) and in the TPTX rats from 5.3 +/- 2.5 to 22.4 +/- 6.3% (p less than 0.001). It is concluded that endogenous parathyroid hormone has no major effect on the saline-induced inhibition of reabsorption of SO4.
mesh_terms: D000042:Absorption; D000818:Animals; D005260:Female; D010280:Parathyroid Glands / Q000502:physiology*; D010710:Phosphates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology*; D013431:Sulfates / Q000378:metabolism*; D013965:Thyroidectomy
chemical_list: D010710:Phosphates; D013431:Sulfates; D012965:Sodium Chloride