Radiation target analysis of glycoproteins.
The radiation sensitivity of glycoproteins is shown to depend only on the protein portion of the molecule. An artificially created glycoprotein containing glucose-6-phosphate dehydrogenase observes this rule as well as natural enzymes and receptors containing from 2 to 50% carbohydrate. No exceptions have been found. Radiation damage to carbohydrates occurs close to the site of the primary ionization, with little spread of damage into attached polypeptides.
D001665:Binding Sites; D002241:Carbohydrates / Q000528:radiation effects; D004583:Electrons; D004800:Enzymes, Immobilized / Q000528:radiation effects; D005615:Freezing; D005954:Glucosephosphate Dehydrogenase / Q000528:radiation effects; D006023:Glycoproteins / Q000528:radiation effects*; D010455:Peptides / Q000528:radiation effects
D002241:Carbohydrates; D004800:Enzymes, Immobilized; D006023:Glycoproteins; D010455:Peptides; D005954:Glucosephosphate Dehydrogenase