Binding of gastrin to gastric transferrin.
Binding of 125I-gastrin to porcine gastric transferrin has been demonstrated by covalent cross-linking with disuccinimidyl suberate. The concentration of gastrin required to reduce cross-linking by 50% was approx. 100 microM. The occurrence of both gastrin and gastric transferrin in porcine gastric mucosa and lumen suggests a novel synergistic role for the observed interaction in the uptake of dietary iron.
D000818:Animals; D001665:Binding Sites; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism*; D011485:Protein Binding; D013552:Swine; D014168:Transferrin / Q000378:metabolism*
D005755:Gastrins; D014168:Transferrin