Effect of tizanidine on body temperature in the mouse.
The effect of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2,1, 3-benzothiadiazole] on core temperature in the mouse was investigated in comparison with that of clonidine. Tizanidine decreased core temperature in unanaesthetized, freely-moving normal mice. Clonidine produced hypothermia in normal mice. The alpha 2-antagonist yohimbine produced an antagonism to tizanidine- and clonidine-induced hypothermia, while naloxone failed to antagonize the hypothermia. It is concluded that tizanidine and clonidine produce a similar hypothermic effect via an alpha 2-adrenoreceptor, but not an endogenous opioid system.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D003000:Clonidine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015016:Yohimbine / Q000494:pharmacology
D015016:Yohimbine; C023754:tizanidine; D003000:Clonidine