Lipid peroxidation by gamma-radiation in Salmonella typhi membranes: the effect of ascorbic acid.
Lipid peroxidation in isolated membranes of Salmonella typhi occurred following gamma irradiation. The presence of the sensitizer, ascorbic acid, during irradiation resulted in a stimulation in the level of peroxidation. This enhancement of lipid damage could be prevented by the addition of the free radical scavenger sodium formate. Catalase and superoxide dismutase appeared less effective in this respect. Peroxidation in an unsaturated fatty acid and a phospholipid was also affected by gamma radiation and ascorbic acid in a manner similar to that observed in the cell membranes. The results suggest that hydroxyl radicals may be the major species responsible for the increased peroxidation effected by the sensitizer.
D001205:Ascorbic Acid / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D005720:Gamma Rays; D008054:Lipid Peroxides / Q000528:radiation effects*; D008566:Membranes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D012485:Salmonella typhi / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D013482:Superoxide Dismutase / Q000378:metabolism
D008054:Lipid Peroxides; D002374:Catalase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid