On the role of K+ on succinic dehydrogenase activity.
The effect of potassium ions on succinic dehydrogenase activity of mitochondria was studied. The results showed that in these organelles K+ induces inhibition of the respiratory control; moreover, in submitochondrial particles potassium inhibits the rate of oxidation of succinate. The results showed also that K+ does not changes the Km for succinate but diminishes the Vmax. In addition, the data provide evidence that mitochondria oxidizing glutamate-malate in a sucrose medium show a higher activity of succinate dehydrogenase than mitochondria incubated in KCl.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D004285:Dogs; D007700:Kinetics; D008929:Mitochondria, Heart / Q000201:enzymology*; D010101:Oxygen Consumption; D011189:Potassium Chloride / Q000494:pharmacology*; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D011189:Potassium Chloride; D000255:Adenosine Triphosphate; D013385:Succinate Dehydrogenase