Implantation, deciduoma formation and live births in mast cell-deficient mice (W/Wv).
The intraluminal injection of oil produced deciduoma formation in ovariectomized, mast cell-normal (+/+) and mast cell-deficient (W/Wv) mice that were treated with exogenous steroids. Oil injection and trauma (e.g. sutures) also produced a deciduoma in ovariectomized +/+ and W/Wv mice that had received a single control (+/+) ovary transplanted under the kidney capsule. After transfers of donor blastocysts, implantation and live births were obtained in +/+ and W/Wv mice containing a single ovary transplant. Our results demonstrate that uterine mast cells are not required for the production of a decidual cell response, implantation, gestation or the birth of live offspring in mice.
D000818:Animals; D003656:Decidua / Q000502:physiology*; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D008407:Mast Cells / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D010052:Ovariectomy; D010053:Ovary / Q000637:transplantation; D011247:Pregnancy; D011555:Pseudopregnancy