Human red blood cell membrane damage by endosulfan.
Endosulfan is a chlorinated hydrocarbon insecticide. Its in vitro toxicity on human red blood cell membrane was studied by staining with a fluorochrome dye, merocyanine-540 (MC-540) and Scanning Electron Microscopy (SEM). At a concentration of 0.001 microgram/ml (1 ppb) endosulfan was found to damage human red cell membranes as demonstrated by fluorescence of 30-50% of red cells on staining with MC-540. This was supported by the finding of crenation and threading of red blood cells under SEM. At concentration of 1 microgram/ml (1 ppm) the cells were markedly damaged.
D004726:Endosulfan / Q000633:toxicity*; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D011744:Pyrimidinones
D006454:Hemoglobins; D011744:Pyrimidinones; C003954:merocyanine dye; D004726:Endosulfan