Clinical digoxin toxicity in the aged in association with co-administered verapamil. A report of two cases and review of the literature.
Digoxin toxicity occurs more commonly in aged than younger individuals. Cardioactive drugs such as quinidine effect digoxin pharmacokinetics so as to increase the potential for digoxin toxicity. The calcium-channel antagonists have become extensively used for cardiac disorders and are often co-administered with digoxin. Despite documented calcium-channel antagonist interactions with digoxin, clinically significant digoxin toxicity associated with their concurrent use is apparently unusual. Two elderly patients receiving digoxin and verapamil simultaneously are presented to demonstrate the clinical importance and potential danger of the concomitant use of these drugs.
D000368:Aged; D004077:Digoxin / Q000009:adverse effects* / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D006331:Heart Diseases / Q000188:drug therapy*; D006801:Humans; D007700:Kinetics; D011802:Quinidine / Q000627:therapeutic use; D014700:Verapamil / Q000627:therapeutic use*
D004077:Digoxin; D014700:Verapamil; D011802:Quinidine