title: Choriocarcinoma associated with ectopic pregnancy.
abstract: Eight patients with choriocarcinoma associated with ectopic pregnancy were treated at the John I. Brewer Trophoblastic Disease Center of Northwestern University Medical School from 1962 through 1981. This represented 4% of the 197 patients with documented choriocarcinoma or 1.7% of all 459 patients with gestational trophoblastic disease treated with chemotherapy at the center during this 20-year period. The presenting signs and symptoms were similar to those classically outlined for ectopic pregnancies: amenorrhea and abdominal pain (88%), irregular vaginal bleeding (75%), positive pregnancy test (100%), and adnexal mass (50%). Six patients (75%) had metastatic disease and four of these six had one or more high-risk factors. Two patients (25%) died of metastatic disease, both of whom had received chemotherapy elsewhere before referral to the center.
mesh_terms: D000005:Abdomen; D000568:Amenorrhea / Q000209:etiology; D002822:Choriocarcinoma / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D010146:Pain / Q000209:etiology; D011247:Pregnancy; D011258:Pregnancy Tests; D011274:Pregnancy, Tubal / Q000150:complications* / Q000175:diagnosis; D012306:Risk; D014592:Uterine Hemorrhage / Q000209:etiology; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000209:etiology*