Pseudomyxoma peritonei: effect of chronic continuous immunotherapy with a streptococcal preparation, OK-432 after surgery.
Three cases of pseudomyxoma peritonei with ovarian neoplasma were treated by adjunctive immunotherapy with OK-432 after surgery. In 2 of the 3 cases, the periods of intramuscular injection of OK-432 were 11 and 16 months, respectively, and the 2 patients remain clinically free from evidence of disease, 7 and 6 years after surgery. The third patient is still undergoing treatment, with no evidence of recurrence at 4 months after surgery. These results, although for a small number of patients, clearly suggest that adjunctive immunotherapy with OK-432 may be suitable for treating pseudomyxoma peritonei of ovarian tumor origin.
D000368:Aged; D001688:Biological Products / Q000627:therapeutic use*; D003537:Cystadenoma / Q000473:pathology / Q000628:therapy*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology / Q000628:therapy*; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000628:therapy*; D010844:Picibanil / Q000627:therapeutic use*; D012882:Skin Tests
D001688:Biological Products; D010844:Picibanil