Precursors of mesotocin and vasotocin in birds: identification of VLDV- and MSEL- neurophysins in chicken, goose, and ostrich.
Precursors of neurohypophysial hormones are small proteins processed into nonapeptide hormones and neurophysins during axonal transport to the neurohypophysis. In mammals, oxytocin is associated with VLDV-neurophysin and vasopressin with MSEL-neurophysin. In birds, mesotocin and vasotocin are found instead of mammalian oxytocin and vasopressin. From goose, chicken and ostrich posterior pituitary glands, two types of neurophysins related to mammalian VLDV- and MSEL-neurophysins, respectively, have been identified by their N-terminal sequences. It is assumed that, as in mammals, hormonal peptide and the first 9 residues of the corresponding neurophysin are encoded by a common exon and that mesotocin and vasotocin, evolutionary predecessors of oxytocin and vasopressin, are associated in the precursors with VLDV-neurophysin and MSEL-neurophysin, respectively.
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D002645:Chickens; D005777:Geese; D006736:Horses; D006801:Humans; D009481:Neurophysins / Q000302:isolation & purification*; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000302:isolation & purification; D010902:Pituitary Gland / Q000032:analysis; D011498:Protein Precursors / Q000302:isolation & purification*; D051381:Rats; D012756:Sheep; D013552:Swine; D014668:Vasotocin / Q000302:isolation & purification*; D014907:Whales
D009481:Neurophysins; D011498:Protein Precursors; C001713:mesotocin; D010121:Oxytocin; D014668:Vasotocin