title: Effects of aging on prostate growth in beagles.
abstract: Statistical analysis of 82 variables was completed to determine the effects of aging in the male beagle on prostatic growth and function. The results indicate that prostate weight increased to 4 yr and then reached a plateau. Prostatic secretory function (measured as ejaculate volume) followed a course different than the growth of the gland. Prostatic function increased and reached a peak at 4 yr and then declined abruptly. Therefore, there is a separation of the growth and secretory function of the canine prostate after 4 yr of age. Multiple linear regression analysis was performed to determine the mathematical relationship of these variables in predicting prostate weight and therefore benign prostatic hyperplasia, which is correlated with weight. The testicular secretion of testosterone and aging were paramount factors in predicting prostate weight. There appears to be an increased sensitivity of the prostate to testosterone secretion with advancing age.
mesh_terms: D000375:Aging; D000818:Animals; D004285:Dogs; D006965:Hyperplasia / Q000209:etiology; D008297:Male; D008954:Models, Biological; D009929:Organ Size; D011467:Prostate / Q000201:enzymology / Q000254:growth & development* / Q000378:metabolism / Q000473:pathology; D012044:Regression Analysis; D013739:Testosterone / Q000378:metabolism
chemical_list: D013739:Testosterone