title: 1,3,8-Trimethylallantoin: a major caffeine metabolite formed by rat liver.
abstract: The formation of 1,3,8-trimethylallantoin from caffeine is demonstrated for the first time in vitro in rat liver slices. This compound constitutes 15% of total in vitro metabolites. With this identification, all the metabolic pathways of caffeine shown in vivo (N-demethylation, oxidation to uric acids and formation of uracil and allantoin derivatives) are demonstrated in vitro.
mesh_terms: D000481:Allantoin / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D001711:Biotransformation; D002110:Caffeine / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002855:Chromatography, Thin Layer; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D051381:Rats
chemical_list: D002250:Carbon Radioisotopes; D000481:Allantoin; D002110:Caffeine; C049810:1,3,8-trimethylallantoin