[Progestagenic activity and the mechanism of the contraceptive action of mecygeprone].
Progestagenic activity of a modified analog of progesteron-6 alpha-methyl-cyclogexan-[1', 2', 16 alpha, 17 alpha]-pregn-4-en-3,20-dion including into mecygepron composition has been studied; its activity is proved to be 5 times as great as that of progesteron at any way of administration. Mecygepron affects processes of ovogenesis and early embryogenetic development in rats. A decreased number of washed out embryos is observed, while the number of lutein bodies specific for intact rats remains the same, decelerated rate of cleavage and increased number of unfertilized ova. In the mechanism of the changes observed an essential role plays a decreased secretion of lutropin resulting in a prolonged estrol cycle and, evidently, in intrafollicular overmaturation of the ova, which loose their ability to be fertilized. Besides, the disturbed hormonal balance under mecygepron influence can affect the character of the oviduct and uterine contents and, thus, prevent the normal development of the fertilized gametes.
D000284:Administration, Oral; D000818:Animals; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology*; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D005306:Fertilization / Q000187:drug effects*; D007273:Injections, Intramuscular; D008656:Mestranol / Q000494:pharmacology*; D009866:Oogenesis / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*; D011374:Progesterone / Q000494:pharmacology*; D045167:Progesterone Congeners; D011817:Rabbits
D003277:Contraceptives, Oral, Combined; D045167:Progesterone Congeners; D011374:Progesterone; D008656:Mestranol
Progestagennaia aktivnost' i mekhanizm kontratseptivnogo deĭstviia metsigeprona.