Outcome in children with normal growth following removal of a craniopharyngioma.
Ten children who had normal or excessive growth rates following surgical removal of a craniopharyngioma have been followed. Final adult heights for three were more than 2.5 standard deviations below the mean adult height for sex. Nine of the 10 children showed a deceleration in growth rate that occurred 1.5-6 years following surgery. The deceleration in linear growth did not appear to correlate with changes in weight gain, somatomedin-C, or the integrated insulin response to an oral glucose load. These results suggest that the mechanisms whereby some children with growth hormone deficiency have normal growth rates following neurosurgic procedures are complex. The authors recommend that these children have continued follow-up so that growth hormone therapy may be instituted when appropriate.
D001827:Body Height; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006128:Growth; D013006:Growth Hormone / Q000172:deficiency; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000627:therapeutic use*; D008297:Male; D010911:Pituitary Neoplasms / Q000601:surgery*; D011182:Postoperative Care; D013002:Somatomedins / Q000627:therapeutic use*
D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone