title: [Light- and electron microscopy of human epididymis after estrogen and antiandrogen treatment].
abstract: Epididymal tissue from 8 patients treated with estrogen and antiandrogen for a long time was studied by light- and electron microscopy. There are severe regressive-degenerative changes within the epithelium characterized by a decrease or loss of the normal surface differentiation, a decrease of cell organelles and an increase of phagolysosomes. Hyperplasia of the smooth muscle layer occurs in the extra-epithelial part of the ductus epididymidis.
mesh_terms: D000328:Adult; D000726:Androgen Antagonists / Q000494:pharmacology*; D004822:Epididymis / Q000187:drug effects* / Q000648:ultrastructure; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D006801:Humans; D008247:Lysosomes / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D008853:Microscopy; D008854:Microscopy, Electron; D008875:Middle Aged; D009130:Muscle, Smooth / Q000187:drug effects / Q000648:ultrastructure; D009940:Organoids / Q000187:drug effects / Q000648:ultrastructure
chemical_list: D000726:Androgen Antagonists; D004967:Estrogens; D004997:Ethinyl Estradiol; D004958:Estradiol
vernacular_title: Licht- und Elektronenmikroskopische Untersuchungen am menschlichen Nebenhoden nach Ostrogen- und Antiandrogentherapie.