The hypothermic action of carbachol in the rat brain periaqueductal grey area may involve neurotensin.
Neurotensin (NT) and carbachol both caused hypothermia when injected into the periaqueductal grey area (PAG) of rat brain. Atropine prevented carbachol- but not NT-induced hypothermia. NT-induced hypothermia was unaffected by various neurotransmitter agonists and antagonists in the PAG. Both NT antibodies and thyrotrophin releasing hormone prevented carbachol hypothermia. It is concluded that the hypothermic action of carbachol in the PAG is mediated via endogenous NT.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002217:Carbachol / Q000494:pharmacology*; D007267:Injections; D008297:Male; D009496:Neurotensin / Q000502:physiology*; D010487:Periaqueductal Gray; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D009496:Neurotensin; D002217:Carbachol