title: The effects of tolerance on state-dependent learning in social drinkers.
abstract: Sixty drinkers were assigned to three experimental groups which manipulated pre and post drug state. Subjects on learning trials were exposed to 30 slides, composed of geometrical shapes and alcohol-related self-statements. On the day following learning, subjects were required to try and recognise the 30 original slides out of 60 test slides. Signal detection method was used to analyse differences between the groups. Results showed that medium drinkers who consumed an experimental dose similar to their usual dose showed state dependency over both stimuli. Light drinkers showed an impairment on all alcohol-related conditions but alcohol on learning primed the recognition of alcohol-associated stimuli. Heavy drinkers, who drank a dose that was lower than their usual dose, showed little effect. The findings thus showed the importance of controlling for the level of tolerance and the type of stimuli presented in the State Dependent Learning experiments.
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005556:Form Perception / Q000187:drug effects; D006801:Humans; D007858:Learning / Q000187:drug effects*; D008297:Male; D011939:Mental Recall / Q000187:drug effects
chemical_list: D000431:Ethanol