Aztreonam concentration in abdominal tissues and bile.
Abdominal tissue, serum, and bile samples were obtained from 37 patients given a single, 2-g intravenous infusion of aztreonam immediately prior to an elective abdominal operation. Samples were obtained at 0 to 6 h after dosing. Mean concentrations in tissues and fluids and specimen/serum rations are reported. Levels in tissue and bile exceeded the reported MICs for 90% of most members of the family Enterobacteriaceae for up to 6 h.
D000005:Abdomen / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001398:Aztreonam / Q000378:metabolism*; D001646:Bile / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged
D001398:Aztreonam