Lightmicroscopical features of interferon-alpha-treated laryngeal papillomatosis in adults.
Papillomatous tissue samples from 12 adult patients with laryngeal papillomatosis were examined by light microscopy before and after interferon-alpha (IFN) treatment. Increased atypia, a change in intra-epithelial differentiation, sclerosis of the underlying stroma and infiltration of especially plasma cells were found in tumour tissue removed after 3 weeks of IFN treatment. These morphological findings do not explain the effects exerted by IFN on the growth pattern of adult laryngeal papillomatosis, but provide a basis for further studies.
D000328:Adult; D000368:Aged; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000628:therapy; D007830:Larynx / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010212:Papilloma / Q000473:pathology* / Q000628:therapy; D013997:Time Factors
D007370:Interferon Type I