title: [Cytostatic platinum complexes: an unexpected discovery with considerable consequences].
abstract: Antineoplastic platinum complexes represent new-developed inorganic cytostatics, which interfere with intracellular nucleic acids, especially with DNA. The main representative is cis-diamminedichloroplatinum (II) (cis-platin, DDP). It has proven effective against human urogenital tumors and against carcinomas of the head and neck. The most severe side effects are nephrotoxicity and gastrointestinal irritation. Stimulated by the clinical success of cisplatin, a series of platinum complexes of the second generation has been recently developed. Moreover, anti-tumor properties were detected for various organometallic complexes containing titanium, vanadium, tin, or iron as central atoms.
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D002945:Cisplatin / Q000627:therapeutic use; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D009369:Neoplasms / Q000188:drug therapy*; D009942:Organometallic Compounds / Q000627:therapeutic use; D009944:Organoplatinum Compounds / Q000627:therapeutic use* / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D009944:Organoplatinum Compounds; D002945:Cisplatin
vernacular_title: Cytostatische Platin-Komplexe: eine unerwartete Entdeckung mit weitreichenden Konsequenzen.