title: Encephalopathy and an elevated serum aluminum level in a patient receiving intravesical alum irrigation for severe urinary hemorrhage.
abstract: Intravesical alum irrigation is reported to be an effective and relatively safe means of controlling severe urinary hemorrhage. We describe a patient who experienced severe encephalopathy, metabolic acidosis and unexplained coagulopathy while receiving continuous intravesical alum irrigation. The serum aluminum level was elevated. The probable role of alum absorption from the bladder as the etiology of the encephalopathy and metabolic abnormalities, as well as the pathophysiology of aluminum metabolism are discussed. Guidelines for the use of intravesical alum irrigation in patients at high risk for the development of these abnormalities are proposed.
mesh_terms: D000368:Aged; D000534:Alum Compounds; D000535:Aluminum / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood*; D001927:Brain Diseases / Q000139:chemically induced*; D006470:Hemorrhage / Q000188:drug therapy*; D006801:Humans; D008297:Male; D013431:Sulfates / Q000008:administration & dosage / Q000009:adverse effects*; D007507:Therapeutic Irrigation; D001745:Urinary Bladder Diseases / Q000188:drug therapy*
chemical_list: D000534:Alum Compounds; D013431:Sulfates; C041524:aluminum sulfate; D000535:Aluminum