title: [Pharmacological characteristics of desoxypeganine hydrochloride].
abstract: Desoxypeganine hydrochloride isolated from Peganum harmala L. caused in animals a pronounced depression of cholinesterase activity. By anticholinesterase activity desoxypeganine was ten times superior peganine hydrochloride and 2 times galanthamine hydrochloride. In the experiments on anesthetized cats desoxypeganine hydrochloride eliminated blockade of neuromuscular conductivity induced by diplacine and on the contrary enhanced blockade induced by ditilin. It increases sensitivity to acetylcholine of the straight abdominal muscle of the frog and isolated segments of the small intestine. Desoxypeganine hydrochloride is used for treatment of patients with lesions of the peripheral nervous system.
mesh_terms: D000470:Alkaloids / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002800:Cholinesterase Inhibitors / Q000494:pharmacology* / Q000633:toxicity; D005702:Galantamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D009469:Neuromuscular Junction / Q000187:drug effects; D010946:Plants, Medicinal; D011763:Pyrrolizidine Alkaloids / Q000494:pharmacology; D011799:Quinazolines; D011817:Rabbits; D011898:Ranidae; D011976:Receptors, Muscarinic / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D013390:Succinylcholine / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D011763:Pyrrolizidine Alkaloids; D011799:Quinazolines; D011976:Receptors, Muscarinic; D005702:Galantamine; C004268:diplacin; C048835:3-deoxyvasicine; C019592:vasicine; D013390:Succinylcholine
vernacular_title: Farmakologicheskaia kharakteristika dezoksipeganina gidrokhlorida.