[Value of the 14C-aminophenazone inhalation test: inhibition of the demethylation function of the liver by cimetidine].
On 15 patients with healthy liver and with a peptic ulcer the demethylation capacity of the liver was measured with the 14C-aminophenazone breathing test before the treatment and during the treatment with the H2-antagonist cimetidine (daily dose 1.0 g). As measure of the demethylation capacity the breathed out 14CO2 (DPM/mmol CO2/70 kg body weight) before and 1 hour after intake was chosen. Under influence of cimetidine the mean 14CO2-value of 724.7 DPM (S.D. 127.7) decreased to 404.1 DPM (S. D. 153.1). The enzyme activities (ALAT, ASAT, AP, AAP, GGT, CHE) and the concentrations of serum bilirubin and serum albumin remained unchanged and did not correlate mutually and with the 14CO2-data. The results confirm the independence of the aminophenazone test as technique for the recognition of disturbance of the MFO-system.
D000328:Adult; D000632:Aminopyrine / Q000378:metabolism; D002927:Cimetidine / Q000009:adverse effects* / Q000627:therapeutic use; D065607:Cytochrome P-450 Enzyme Inhibitors; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008658:Inactivation, Metabolic; D008111:Liver Function Tests / Q000379:methods*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D008875:Middle Aged; D013276:Stomach Ulcer / Q000188:drug therapy*
D065607:Cytochrome P-450 Enzyme Inhibitors; D000632:Aminopyrine; D002927:Cimetidine
Zur Wertigkeit des 14C-Aminophenazon-Atemtests: Hemmung der Demethylierungsfunktion der Leber durch Cimetidin.