Acetate and citrate stimulate water and sodium absorption in the human jejunum.
Using a standard perfusion technique, the organic anions acetate (50 mmol/l) and citrate (5 mmol/l) have been shown to stimulate absorption of water and sodium from the human jejunum. These observations may support further the rationale for including acetate or citrate in oral rehydration solutions for the treatment of acute diarrhoeal disease in humans.
D000085:Acetates / Q000494:pharmacology*; D019342:Acetic Acid; D002951:Citrates / Q000494:pharmacology*; D019343:Citric Acid; D003967:Diarrhea / Q000628:therapy; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism; D010477:Perfusion; D012964:Sodium / Q000378:metabolism*; D014867:Water / Q000378:metabolism*
D000085:Acetates; D002951:Citrates; D014867:Water; D019343:Citric Acid; D012964:Sodium; D019342:Acetic Acid