Trace elements in normal and cirrhotic human liver tissue. I. Iron, copper, zinc, selenium, manganese, titanium and lead measured by X-ray fluorescence spectrometry.
Trace elements (Fe, Cu, Zn, Se, Mn, Ti, Pb) were measured by X-ray fluorescence spectrometry in normal liver tissue obtained at autopsy from 74 subjects (44 male, 30 female), median age 62 years (range 20-87), and in tissue from 27 cirrhotic livers (14 alcoholic, 13 non-alcoholic cirrhosis). The element content (median and 5-95 percentile interval) in normal livers in mmol/kg dry tissue was: Fe, 16.51 (7.82-39.03); Cu, 0.378 (0.189-0.629); Zn, 4.01 (2.59-9.33); Se, 0.018 (less than 0.004-0.035); Mn, less than 0.055 (less than 0.055-0.237); Ti, less than 0.146 (less than 0.146-0.919); Pb, less than 0.0005 (less than 0.0005-0.0154). Only copper content showed a sex difference, being higher in males than in females (P less than 0.04). In both groups of cirrhotic liver, Fe content was within normal, Cu content above normal (P less than 0.05, P less than 0.02), and Se content below normal (P less than 0.0001, P less than 0.04). Alcoholic cirrhotic livers had lower Zn levels (P less than 0.02), higher Mn levels (P less than 0.06), and higher Pb levels (P less than 0.03) than normal livers.
D000328:Adult; D000367:Age Factors; D000368:Aged; D003300:Copper / Q000032:analysis; D005260:Female; D006801:Humans; D007501:Iron / Q000032:analysis; D007854:Lead / Q000032:analysis; D008099:Liver / Q000032:analysis*; D008103:Liver Cirrhosis / Q000378:metabolism*; D008104:Liver Cirrhosis, Alcoholic / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000032:analysis; D008875:Middle Aged; D012643:Selenium / Q000032:analysis; D012737:Sex Factors; D013052:Spectrometry, X-Ray Emission; D014025:Titanium / Q000032:analysis; D014131:Trace Elements / Q000032:analysis*; D015032:Zinc / Q000032:analysis
D014131:Trace Elements; D007854:Lead; D008345:Manganese; D003300:Copper; D014025:Titanium; D007501:Iron; D012643:Selenium; D015032:Zinc