title: Membrane potential and intracellular potassium and sodium activities after denervation of soleus muscles of neonatal rats.
abstract: Potassium and sodium ion-selective microelectrodes were used in vitro to investigate the depolarization of slow-twitch skeletal muscle fibers (soleus) following denervation at 5 to 6 days of age. The normal increase in intracellular potassium ion activity and decrease in sodium ion activity which occurs during the first 3 weeks of life were delayed or prevented by denervation. The results are compared with those found after similar periods of denervation of neonatal rat fast-twitch muscle.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D005260:Female; D006614:Hindlimb; D007425:Intracellular Membranes / Q000378:metabolism*; D008297:Male; D008564:Membrane Potentials; D009121:Muscle Denervation; D009132:Muscles / Q000378:metabolism / Q000502:physiology*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*
chemical_list: D012964:Sodium; D011188:Potassium