Renal lesions in subacute encephalomyelopathy (Leigh's disease).
A case of subacute necrotizing encephalomyelopathy (SNE; Leigh's disease) in an infant aged 19 months is reported. In addition to the typical central nervous lesions, hyperlactatemia and hyperpyruvatemia and morphological changes in the kidney were documented and have been identified as a tubulo-interstitial disease with a focal sclerosing glomerulopathy.
D001928:Brain Diseases, Metabolic / Q000150:complications*; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000473:pathology; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000150:complications* / Q000473:pathology; D007888:Leigh Disease / Q000150:complications*; D008297:Male