title: Freeze-fracture analysis of intramembrane particles of erythrocytes from normal and dystrophic hamsters.
abstract: The intramembrane particles on plasma membranes of erythrocytes of Syrian hamsters afflicted with hereditary muscular dystrophy were compared to those from normal controls by freeze-fracture analysis. The reduced number of particles in both fracture faces of dystrophic erythrocyte plasmalemmae, as compared to that of control red cells, was found to be highly significant (P = .001). Results of this study therefore, support the concept of a generalized membrane defect (abnormality) in muscular dystrophy.
mesh_terms: D000818:Animals; D006224:Cricetinae; D004910:Erythrocyte Membrane / Q000648:ultrastructure*; D005260:Female; D005614:Freeze Fracturing; D008297:Male; D008647:Mesocricetus; D008854:Microscopy, Electron; D009137:Muscular Dystrophy, Animal / Q000235:genetics / Q000473:pathology*; D010316:Particle Size