title: [Myelinotoxic activity of the serum in multiple sclerosis patients].
abstract: The diagnostic significance of the myelinotoxic activity (MA) of the blood serum was studied in patients with multiple sclerosis (MS). The method was based on radiometric determination of 3H cholesterol utilization under the influence of blood sera in the culture of nervous tissue. The study involved 110 MS patients and 21 patients with other diseases of the nervous system. MA in the blood was observed in 86% of the MS patients and in only 14.7% of patients with non-demyelinating diseases. Clinico-laboratory correlations were determined. The method employed was found to be both diagnostically and prognostically valuable.
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001921:Brain / Q000276:immunology* / Q000378:metabolism; D002531:Cerebellum / Q000276:immunology; D002540:Cerebral Cortex / Q000276:immunology; D002784:Cholesterol; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000276:immunology*; D009186:Myelin Sheath / Q000276:immunology*; D011379:Prognosis; D051381:Rats
chemical_list: D007106:Immune Sera; D002784:Cholesterol
vernacular_title: Mielinotoksicheskaia aktivnost' syvorotki krovi u bol'nykh rasseiannym sklerozom.