Effects of ascorbic acid in vivo on the fatty acid composition of the tissues of mice treated with Gramoxone.
The effects of the simultaneous administration of ascorbic acid and the LD50 of paraquat (an ingredient of Gramoxone), and of ascorbic acid pretreatment followed by the LD50 of paraquat, were studied on the phospholipid and triglyceride fatty acid levels in homogenates of mouse lung, liver and kidney. Ascorbic acid treatment increases the content of polyunsaturated fatty acids in the lung considerably, i.e. the pulmonary membrane fluidity decreases significantly in response to ascorbic acid. In the liver homogenate, the membrane fluidity is significantly increased by ascorbic acid pretreatment, and significantly decreased by simultaneous ascorbic acid treatment. In the renal tissue, the result of ascorbic acid pretreatment exhibits a similar tendency to that of paraquat treatment, but a more significant one, while the administration of ascorbic acid together with paraquat does not cause a substantial change in the fluidity index compared to the control.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D010269:Paraquat / Q000633:toxicity*
D005227:Fatty Acids; D010269:Paraquat; D001205:Ascorbic Acid