title: The effect of chronic ethanol ingestion on the inotropic effect of nifedipine.
abstract: The effect of chronic ethanol ingestion on the positive and negative inotropic effects of nifedipine were tested using isolated rat left atria in a force transducing system. There was a significant relative and absolute decrease in the positive inotropic effect of nifedipine in tissues from rats ingesting ethanol (E) as compared to tissue from non-ethanol ingesting rats (N) at low nifedipine concentrations. This change may be mediated by a change in efficiency of the contractile apparatus or membrane fluidity.
mesh_terms: D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D006325:Heart Atria / Q000187:drug effects; D008560:Membrane Fluidity / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects*; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats
chemical_list: D009543:Nifedipine