2,2'-Bipyridyl-6-carboxamidoximes with potential antitumor and antimicrobial properties.
A series of derivatives of 2,2'-bipyridyl-6-carboxamidoxime which combine structural features of antitumor compounds and of the antifungal antibiotic caerulomycin have been synthesized and evaluated for antitumor, antibacterial and antifungal activities. Many of the studied compounds displayed significant antifungal activity.
D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005658:Fungi / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D010091:Oximes; D011725:Pyridines; D015082:2,2'-Dipyridyl