Decreased NK activity in hairy cell leukemia (HCL): an analysis at the cellular level.
Peripheral blood lymphocytes (PBL) of eleven patients with Hairy Cell Leukemia were studied for surface phenotype and for NK activity against the K 562 cell line (using both the standard 51Cr Release Assay and the Single Cell Cytotoxicity Assay on poly-L-lysine coated coverslips). A significant reduction in NK activity, target binding cells (TBC) and NK active cells (NKa) was detected. In some cases however, despite a very low percentage of NKa, residual NK activity was observed, suggesting an efficient recycling capacity.
D000328:Adult; D000368:Aged; D002860:Chromium Radioisotopes; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D007943:Leukemia, Hairy Cell / Q000276:immunology*; D008214:Lymphocytes / Q000145:classification; D008297:Male; D008875:Middle Aged
D002860:Chromium Radioisotopes