[Effect of unithiol and thymidine on the toxic and therapeutic action of adriamycin].
The influence of unithiol and thymidine treatment on the acute toxicity and therapeutic effect of adriamycin in hemoblastosis La was studied in CBA and C57B1 mice. Unithiol and thymidine were shown to markedly decrease the toxicity of different doses of adriamycin which resulted in a lower mortality and longer survival of the animals. When unithiol and thymidine were administered in combination, their antitoxic effect was added. Since unithiol and thymidine administration does not diminish the therapeutic effect of various doses of adriamycin, unithiol may be recommended for clinical use to decrease adriamycin toxicity in cancer patients.
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D004112:Dimercaprol / Q000031:analogs & derivatives*; D004317:Doxorubicin / Q000009:adverse effects / Q000627:therapeutic use*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D051381:Rats; D013936:Thymidine / Q000627:therapeutic use*; D014494:Unithiol / Q000627:therapeutic use*
D000931:Antidotes; D004112:Dimercaprol; D014494:Unithiol; D004317:Doxorubicin; D013936:Thymidine
Vliianie unitiola i timidina na toksicheskoe i lechebnoe deĭstvie adriamitsina.