[Use of malate and NAD for the correction of the blood supply and oxygen balance of the acutely ischemic myocardium].
The experiments on cats under the conditions of acute myocardial ischemia showed that malate (20 and 100 mg/kg) and NAD (0.2 and 2 mg/kg) are able of increasing the coronary blood flow against the background of insignificantly increased oxygen consumption by the heart. The combination of these drugs (malate 100 mg/kg + NAD 0.2 mg/kg) produces an increase in the coronary blood flow and a dramatic raise in cardiac oxygen consumption.
D000208:Acute Disease; D000818:Animals; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D008293:Malates / Q000627:therapeutic use*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009243:NAD / Q000627:therapeutic use*; D010101:Oxygen Consumption / Q000187:drug effects*
D008293:Malates; D009243:NAD
Primenenie malata i NAD dlia korrektsii krovoobrashcheniia i kislorodnogo balansa ostroishemizirovannogo miokarda.