Combination of oxitropium bromide and salbutamol in the treatment of asthma with pressurized aerosols.
The bronchodilator effect of a combination of 200 micrograms salbutamol and 200 micrograms oxitropium bromide, given as pressurized aerosols, was compared to that of 200 and 400 micrograms of salbutamol in a controlled experiment on adult patients with asthma. The combined and the high dose salbutamol treatments were equally effective with respect to the response measured 60 minutes after administration, and both were significantly superior to the low dose salbutamol treatment. Bronchodilation persisted longer following the combined treatment than following the low or high dose salbutamol treatment. The results suggest that enhancement of the early bronchodilator response obtained by adding oxitropium bromide to a conventional dose of salbutamol in patients with stable asthma reflects suboptimal dosing of salbutamol rather than differences between the agents in mechanisms of action, whereas enhancement in duration of response is related also to the pharmacological characteristics of oxitropium bromide.
D000328:Adult; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage* / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012602:Scopolamine Derivatives / Q000008:administration & dosage* / Q000627:therapeutic use
D000336:Aerosols; D012602:Scopolamine Derivatives; C017590:oxitropium; D000420:Albuterol