Interactions of liposomes with serum proteins.
The interactions of serum proteins are diverse, complex and can lead to dramatic effects on liposome stability and in vivo behavior; conversely lipids can modify the biological activities of serum proteins. Serum lipoproteins can potentially destabilize bilayer membranes leading to vesicle disruption and loss of contents; irregularities in the lipid bilayer, such as those which exist at phase boundaries, promote the destabilizing effects of lipoproteins. Other serum components such as fibronectin, immunoglobulins and C reactive protein can modify the biological properties of liposomes by promoting interactions with reticuloendothelial cells and/or activation of the complement system. Liposomes can avidly bind certain serum clotting factors, a process which can lead to dramatic effects on the clotting cascade. Thus the interactions of liposomes with serum proteins can reciprocally effect both components involved.
D001779:Blood Coagulation Factors / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D005353:Fibronectins / Q000097:blood; D006801:Humans; D007700:Kinetics; D008051:Lipid Bilayers; D008074:Lipoproteins / Q000097:blood; D008081:Liposomes; D010743:Phospholipids / Q000097:blood*; D011485:Protein Binding; D013816:Thermodynamics
D001779:Blood Coagulation Factors; D001798:Blood Proteins; D005353:Fibronectins; D008051:Lipid Bilayers; D008074:Lipoproteins; D008081:Liposomes; D010743:Phospholipids; D002097:C-Reactive Protein