[Effect of inhibitors of DNA synthesis on the sensitivity of mammalian cells to radiation with different levels of linear energy transfer].
Radiosensitivity of Chinese hamster cells increased by 1.71 times in the presence of arabinoside cytosine and hydroxyurea after gamma-irradiation, and no sensitization occurred after irradiation with carbon ions of 6.6 MeV/nuclon (LET, 227 keV/micron). Under a standard set of conditions, the RBE coefficient of carbon ions decreased from 3.09 to 1.78 in the presence of DNA synthesis inhibitors. The possible mechanism of this phenomenon is discussed.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D003561:Cytarabine / Q000494:pharmacology; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D004735:Energy Transfer; D005720:Gamma Rays; D006918:Hydroxyurea / Q000494:pharmacology; D012062:Relative Biological Effectiveness
D003561:Cytarabine; D006918:Hydroxyurea
Vliianie ingibitorov sinteza DNK na chuvstvitel'nost' kletok mlekopitaiushchikh k deĭstviiu izlucheniĭ s raznoĭ lineĭnoĭ peredacheĭ énergii.