A misleading flow cytometric analysis of DNA in an adenocarcinoma: a comparative flow cytometric and cytogenetic study.
A case is presented in which flow cytometric and cytogenetic analysis was done on a biopsy from a highly anaplastic metastatic adenocarcinoma. Flow cytometric analysis of DNA content failed to show a significant population of aneuploid cells. However, histologic examination revealed a substantial number of tumor cells, and cytogenetic analysis produced chromosome counts ranging from 20 to 144.
D000230:Adenocarcinoma / Q000032:analysis / Q000235:genetics*; D000782:Aneuploidy; D001706:Biopsy; D004273:DNA, Neoplasm / Q000032:analysis* / Q000235:genetics; D005188:False Negative Reactions; D005434:Flow Cytometry; D006801:Humans; D007621:Karyotyping; D008198:Lymph Nodes / Q000032:analysis; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged
D004273:DNA, Neoplasm