[Effect of phosphatidylcholine on the body temperature and activity of posterior hypothalamus neurons in animals].
The experiments on rats and rabbits have shown that exogenous phosphatidyl choline (PC) was capable of altering the body temperature and bioelectrical activity of posterior hypothalamus neurons following intravenous and intracerebroventricular administration. Intracerebroventricular PC was more effective in raising the body temperature of rats. The experiments on rabbits have demonstrated that the influence of PC (intravenous administration) on the body temperature depended on the initial body temperature. In rabbits, the changes in the impulse activity of certain non-thermosensitive posterior hypothalamus neurons induced by intracerebroventricular PC administration were found to be dependent on the initial firing rates. PC inhibited the increase in bioelectrical activity of thermosensitive neurons in posterior hypothalamus caused by the rise in the brain temperature secondary to body temperature elevation.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002217:Carbachol / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects*; D007034:Hypothalamus, Posterior / Q000187:drug effects* / Q000502:physiology; D008081:Liposomes / Q000008:administration & dosage; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats
D008081:Liposomes; D010713:Phosphatidylcholines; D002217:Carbachol; D009638:Norepinephrine
Vliianie fosfattidilkholina na temperaturu tela i aktivnost' neĭronov zadnego gipotalamusa u zhivotnykh.