Muir-Torre syndrome. Histologic spectrum of sebaceous proliferations.
The sebaceous proliferations seen in patients with Muir-Torre syndrome are unique and difficult to classify. Having reviewed over 50 skin biopsies from five patients with Muir-Torre syndrome, we conclude that the primary proliferation involves the hair follicle and most often resembles either a keratoacanthoma or a sebaceous proliferation, but may have histologic features of both lesions. Unusual patterns seen in the sebaceous components may include solid basaloid sheets, mucinous areas, and convoluted glands.
D000236:Adenoma / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007636:Keratoacanthoma / Q000473:pathology; D012626:Sebaceous Gland Neoplasms / Q000473:pathology*; D012627:Sebaceous Glands / Q000473:pathology; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology; D013577:Syndrome