[Effect of the immunization of rats with tularemia vaccine on the number of cytogenetic disorders in somatic cells induced by cytostatics].
Cytogenetic disturbances due to cytostatic preparations--cyclophosphamide and methylnitrosourea--applied as single or ten-times administrations in different doses have been studied for rats immunized with tularemia live dried vaccine. It is established that with the application of these preparations to immunized animals the quantity of chromosomal aberrations in myelokaryocytes decreased from 1.4 to 2.2 times, compared with that in non-immunized animals.
D000818:Animals; D000970:Antineoplastic Agents; D001428:Bacterial Vaccines / Q000276:immunology*; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations; D003520:Cyclophosphamide; D004305:Dose-Response Relationship, Drug; D005260:Female; D005604:Francisella tularensis / Q000276:immunology*; D007114:Immunization; D008297:Male; D008677:Metaphase / Q000187:drug effects; D008770:Methylnitrosourea; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D001428:Bacterial Vaccines; D008770:Methylnitrosourea; D003520:Cyclophosphamide
Vliianie immunizatsii krys tuliaremiĭnoĭ vaktsinoĭ na kolichestvo tsitogeneticheskikh narusheniĭ v somaticheskikh kletkakh, indutsiruemykh nekotorymi tsitostatikami.