title: Renal innervation is not required for compensatory renal growth in the rat.
abstract: The purpose of this study was to determine whether renal innervation is required for compensatory growth of the remaining kidney following unilateral nephrectomy. In the first study, young (6-week-old) rats were divided into 4 groups and the following surgical procedures were performed. Group 1 animals had their left and right kidneys removed and weighed to provide a measure of control weight prior to compensatory growth. Group 2 and 3 animals underwent right nephrectomy, followed by left kidney denervation (Group 2) or sham denervation (Group 3). Animals from Group 4 were subjected to right sham nephrectomy and sham denervation of the left kidneys. Three weeks later, animals from Groups 2, 3 and 4 were sacrificed and left kidneys were weighed. Relative to control kidney weight (Group 1), left kidney weight increased over 3 weeks by 92% when both kidneys were present (Group 4), representing normal renal growth. Animals with prior nephrectomy but intact renal innervation (Group 3) demonstrated an additional increase in kidney weight of 74% over the same interval, representing compensatory growth. Prior denervation of the left kidney (Group 2) had no effect on the degree of compensatory growth whether expressed in absolute kidney weight or relative to body weight. A second study was performed to determine whether renal innervation influences the initial state of compensatory growth when measured at an earlier time after unilateral nephrectomy. One week after right nephrectomy, left kidney weight was similar in animals with sham left renal denervation (1.08 +/- 0.04 g) when compared to animals with left renal denervation (1.06 +/- 0.02 g). Thus, for a least young rats, renal innervation is not required for full compensatory renal growth following unilateral nephrectomy.
mesh_terms: D000818:Animals; D003714:Denervation; D007668:Kidney / Q000254:growth & development / Q000294:innervation*; D008297:Male; D009392:Nephrectomy; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains