Regulatory effects of gastrin and secretin on carcinomas of the stomach and colon.
Gastrin (10 micrograms/ml) enhanced 14C-leucine uptake in cultured tissue of stomach and colon carcinomas and content of 14C-labelled protein in the medium was increased. One of 2 stomach and one of 3 colon carcinomas transplanted into nude mice were enhanced in growth by pentagastrin injected in a dose of 250 micrograms/kg every day. On the other hand, secretin (100 U/kg) inhibited the trophic action of pentagastrin.
D000230:Adenocarcinoma / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D003110:Colonic Neoplasms / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D007930:Leucine / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009368:Neoplasm Transplantation; D010418:Pentagastrin / Q000494:pharmacology*; D012633:Secretin / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000503:physiopathology*
D009363:Neoplasm Proteins; D012633:Secretin; D010418:Pentagastrin; D007930:Leucine