Characterization of an expanded subpopulation of large granular lymphocytes in a patient with rheumatoid arthritis.
We describe a rheumatoid arthritis patient who was found to have chronic T cell lymphocytosis and neutropenia. She had an increased number of lymphocytes in the peripheral blood, bone marrow, and liver, and the expanded lymphocyte subset consisted of large granular lymphocytes with a homogeneous phenotype. Of the previously described patients with these large granular lymphocytes, almost one-fourth have had rheumatoid arthritis.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000145:classification*; D008218:Lymphocytosis / Q000097:blood; D009503:Neutropenia / Q000097:blood; D010641:Phenotype