Production of IgA monoclonal antibodies against influenza A virus.
Nineteen IgA monoclonal antibodies against influenza A virus X-31 were obtained following intranasal infection of mice with influenza A virus X-31. It was demonstrated that specificities of IgA monoclonal antibodies are similar to those of IgG monoclonal antibodies. These IgA antibodies might be useful for the study of mucosal immunity against influenza A viruses. Infection may be an easier and better way of producing monoclonal antibodies against some viral agents.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D006385:Hemagglutination Inhibition Tests; D007070:Immunoglobulin A / Q000378:metabolism*; D007074:Immunoglobulin G / Q000378:metabolism; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice
D000911:Antibodies, Monoclonal; D007070:Immunoglobulin A; D007074:Immunoglobulin G