Effect of polyamines on perfused rat heart contractility.
The influence of polyamines (putrescine, spermidine and spermine) on heart contractility was studied using perfused rat ventricle strips (2 X 10 mm), electrically driven at 1 Hz. Putrescine (100 microM) caused a negative inotropic effect gradually increasing in intensity, whereas spermidine and spermine (10 and 100 microM) caused a sharp, positive inotropic effect, followed by a rapid and more marked fall. The possibility that these effects of polyamines on heart contractility may be due to their role in Ca++ fluxes and mobilization, and in membrane functions, is discussed.
D000818:Animals; D002118:Calcium / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D010477:Perfusion; D011073:Polyamines / Q000494:pharmacology*; D011700:Putrescine / Q000494:pharmacology; D051381:Rats; D013095:Spermidine / Q000494:pharmacology; D013096:Spermine / Q000494:pharmacology
D011073:Polyamines; D013096:Spermine; D002118:Calcium; D013095:Spermidine; D011700:Putrescine