First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist.
An antagonist to amino acid evoked excitation, gamma-D-glutamylglycine (gamma-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive afferent C-fibres. These results might be useful for development of centrally acting analgesic drugs.
D000596:Amino Acids / Q000037:antagonists & inhibitors; D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D009433:Neural Inhibition / Q000187:drug effects*; D009619:Nociceptors / Q000187:drug effects*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology; D013569:Synapses / Q000187:drug effects*
D000596:Amino Acids; D004151:Dipeptides; C028929:gamma-glutamylglycine