Drug holidays and serum haloperidol levels in schizophrenic patients.
Chronic hospitalized schizophrenic patients receiving haloperidol were placed on drug holidays for 2 days. Serum haloperidol levels in these patients decreased to about 60% of the levels seen just prior to the usual morning dosing during the drug holiday. Control subjects not given a drug holiday showed stable day-to-day serum haloperidol levels. The small drop in serum haloperidol blood levels may relate to the lack of relapse observed in such patients.
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004334:Drug Administration Schedule; D006220:Haloperidol / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D006760:Hospitalization; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*
D006220:Haloperidol