Effect of phosphocreatine and related compounds on the phospholipid metabolism of ischemic heart.
Changes in the content of lysophosphoglycerides in a crude plasmalemmal fraction of canine heart during short-term ischemia (occlusion of the left descending coronary artery for 8 min) have been studied in the presence and in the absence of phosphocreatine and phosphocreatinine. In the control experiments without PCr or PCr-nine ischemia caused significant elevation of the content of LPG: that of lysophosphatidylcholine was increased by 83% and that of lysophosphatidylethanolamine by 168%. Intravenous administration of PCr and PCr-nine in doses of 300 mg/kg completely prevented accumulation of LPG in the ischemic zone. Because of the well-known arrhythmogenic properties of LPG, the inhibitory effect of PCr and PCr-nine on the elevation of their concentration in the ischemic zone may be closely related to the antiarrhythmic action of PCr and PCr-nine in acute myocardial ischemia.
D000818:Animals; D002855:Chromatography, Thin Layer; D003327:Coronary Disease / Q000378:metabolism*; D004285:Dogs; D005260:Female; D006321:Heart / Q000187:drug effects; D007700:Kinetics; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010725:Phosphocreatine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010743:Phospholipids / Q000302:isolation & purification / Q000378:metabolism*
D010743:Phospholipids; D010725:Phosphocreatine; C025403:phosphocreatinine