title: Hypertension in bulls and steers anesthetized with guaifenesin-thiobarbiturate-halothane combination.
abstract: Eight bulls and steers (research animals) and 18 bulls (surgical patients) were anesthetized with guaifenesin and thiopental or thiamylal and for 90 minutes with halothane. Arterial blood pressure and heart rate were recorded in all animals. Cardiac output, plasma glucose and lactate concentrations, PCV, plasma proteins and plasma thromboxane B2 values were determined before (control) and every 15 minutes during anesthesia in the research animals. Plasma catecholamine concentrations were measured in 3 of the research animals and 3 of the surgical patients. Arterial pressure, heart rate, and plasma thromboxane B2 and catecholamine concentrations were also measured immediately after the trachea was intubated. All animals, except one, were hypertensive during anesthesia. Heart rate during anesthesia was significantly increased, compared with control measurements, and cardiac output was decreased. Plasma glucose and lactate values significantly increased when the animals were restrained on their sides. Plasma glucose concentrations remained increased during anesthesia, but lactate decreased. Packed cell volume and plasma proteins were unchanged by the induction of anesthesia. Plasma norepinephrine concentration was unchanged during anesthesia, and epinephrine concentration was decreased. Endotracheal intubation caused a transient significant increase in arterial pressure, heart rate, and thromboxane B2 and a nonsignificant increase in norepinephrine.
mesh_terms: D000768:Anesthesia, General / Q000009:adverse effects*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D001798:Blood Proteins / Q000032:analysis; D002417:Cattle; D004837:Epinephrine / Q000097:blood; D004911:Erythrocyte Volume / Q000187:drug effects; D006140:Guaifenesin / Q000009:adverse effects*; D006221:Halothane / Q000009:adverse effects*; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced*; D007773:Lactates / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000097:blood; D009919:Orchiectomy; D013858:Thiobarbiturates / Q000009:adverse effects*; D013929:Thromboxane B2 / Q000097:blood
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D007773:Lactates; D013858:Thiobarbiturates; D006140:Guaifenesin; D013929:Thromboxane B2; C029684:thiobarbituric acid; D006221:Halothane; D009638:Norepinephrine; D004837:Epinephrine