Prompt termination and/or prevention of cold-pressor-stimulus-induced vasoconstriction of different vascular beds by magnesium sulfate in patients with Prinzmetal's angina.
In a group of 15 patients with Prinzmetal's angina, cold-pressor-induced anginal attacks were both promptly terminated and prevented by Mg sulfate. Cold-pressor-induced pulmonary hypertension and Raynaud's phenomenon were successfully prevented. Normalization by MgSO4 of the excessive reactive blood pressure increase in response to the cold stimulus was observed.
D000368:Aged; D000788:Angina Pectoris, Variant / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D003080:Cold Temperature; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood; D008275:Magnesium Deficiency / Q000150:complications; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011653:Pulmonary Diffusing Capacity / Q000187:drug effects; D011928:Raynaud Disease / Q000209:etiology; D014661:Vasoconstriction / Q000187:drug effects*
D008278:Magnesium Sulfate; D008274:Magnesium