title: Molecular cloning of the avian beta-nerve growth factor gene: transcription in brain.
abstract: A chicken gene cross-hybridizing with a murine beta-nerve growth factor (beta NGF) cDNA probe was identified by Southern blot analysis and isolated from a genomic DNA library. The DNA sequence coding for the putative mature beta NGF protein was determined, providing direct evidence for the existence in birds of a neurotrophic factor sharing a high degree of sequence homology with mammalian beta NGF. In addition this gene is shown to be transcriptionally active in adult avian brain as demonstrated by Northern blot analysis.
mesh_terms: D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000502:physiology*; D002645:Chickens / Q000235:genetics; D003001:Cloning, Molecular; D003370:Coturnix / Q000235:genetics; D005796:Genes; D009414:Nerve Growth Factors / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D009414:Nerve Growth Factors