Influence of pharmacological doses of iopanoic acid and thyroxine 5- and 5'-monodeiodination in liver and kidney of the pig.
Short-lasting (24-48 h) IOP administration to growing pigs causes the inhibition of both 5- and 5'-thyroxine monodeiodination in the liver and the kidney. After administration of IOP in vivo or into tissue homogenates, the inhibition of T4 to T3 conversion was stronger than that of T4 to rT3. The inhibitory effect was related to the thyroid hormones concentration in serum and to the age of animals.
D000818:Animals; D007453:Iodide Peroxidase / Q000378:metabolism*; D007480:Iopanoic Acid / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D013552:Swine; D013974:Thyroxine / Q000378:metabolism*; D013997:Time Factors; D014284:Triiodothyronine / Q000378:metabolism; D014285:Triiodothyronine, Reverse / Q000378:metabolism
D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D007453:Iodide Peroxidase; D007480:Iopanoic Acid; D013974:Thyroxine