[Do copper intrauterine devices cause contact allergy?].
Allergological examinations were conducted on 49 women (out of a gynaecological clientele of 982) with different degrees of complaints after wearing an intrauterine device (IUD). At the same time, they and a control group had an histological examination of endometrial biopsies. Nickel allergy was found in 38 of the 49. Nine of them (eight with a nickel sensitivity) reacted within 24 hours to an application of a 1% copper sulphate solution. A reaction was still present 72 hours later in six women. Only one woman still reacted to further dilution of the test solution, but 48-hour application of the copper spiral to her forearm was negative. It is only in this patient that a (though very weak) copper allergy can be accepted with certainty. There was no evidence of an endometrial allergy histologically. The results justify the view that copper allergy is extremely rare.
D000293:Adolescent; D000328:Adult; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000209:etiology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007435:Intrauterine Devices, Copper / Q000009:adverse effects*; D008487:Medical History Taking; D008670:Metals; D009532:Nickel / Q000009:adverse effects / Q000032:analysis; D012882:Skin Tests; D013054:Spectrophotometry, Atomic
D008670:Metals; D009532:Nickel
Verursachen Kupfer-Intrauterinpessare eine Kontaktallergie?