Cytotoxic effect of serotypes of Pasteurella haemolytica on sheep bronchoalveolar macrophages.
Ovine isolates of the 15 known serotypes found within the A and T biotypes of Pasteurella haemolytica were cytotoxic for sheep bronchoalveolar macrophages (BAM). Weaker toxicity for the same target cells was also expressed by non-serotypable ovine isolates of P. haemolytica. The results suggest that cytotoxicity for sheep BAM is a virulence factor common to both A and T biotypes of P. haemolytica.
D000818:Animals; D003603:Cytotoxins / Q000032:analysis; D008264:Macrophages / Q000276:immunology*; D010325:Pasteurella / Q000145:classification / Q000472:pathogenicity*; D012703:Serotyping; D012756:Sheep
D003603:Cytotoxins