An Lu(a-b-) phenotype caused by an X-linked recessive gene.
The family of a male Lu(a-b-) propositus whose red cells showed some characteristics of the dominant and some of the recessive type of Lu(a-b-) phenotype was studied. The investigation revealed a third genetic background for this rare phenotype, an X-borne suppressor recessive in effect. The notation proposed is XS1 for the normal gene and XS2 for the suppressor gene which affects the expression of Lutheran and other antigens.
D005260:Female; D005808:Genes, Recessive; D006801:Humans; D008188:Lutheran Blood-Group System / Q000235:genetics*; D008297:Male; D010375:Pedigree; D010641:Phenotype; D013489:Suppression, Genetic; D014960:X Chromosome
D008188:Lutheran Blood-Group System