Age- and strain-dependent polymorphism in IgE antibody against the phosphorylcholine hapten.
The magnitude of the IgE antibody response against the phosphorylcholine (PC) hapten and the rate of age-related change of IgE formation is polymorphic in the three long-lived and six relatively short-lived strains of mice studied. Long-lived mice showed an early increase, followed by a decline in the levels of anti-PC IgE antibody. The rate of increase and decrease was strain dependent. Among short-lived strains, MRL/Mp-lpr and MRL/Mp-+ mice showed an early decline in IgE antibody. The extent and rate of decline with age was more rapid in MRL/Mp-lpr animals than in MRL/Mp-+ mice. In contrast, there was an early increase of IgE antibody in female SJL, NZB/BIN, BXSB/Mp and male BXSB/Mp. Thus, opposite age-related changes in IgE antibody production can occur in animals with a tendency to develop autoimmune disease. In hybrids of (SJL X BALB/c)F1 and (BALB/c X MRL/Mp-lpr)F1, the levels of IgE antibodies were higher than those observed in either parental strain, and declined steeply with advancing age. We suggest that this could be attributed to recessive inheritance.
D000375:Aging; D000818:Animals; D002794:Choline / Q000031:analogs & derivatives*; D003433:Crosses, Genetic; D005260:Female; D006241:Haptens / Q000276:immunology*; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010767:Phosphorylcholine / Q000276:immunology*; D011110:Polymorphism, Genetic; D013045:Species Specificity
D006241:Haptens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010767:Phosphorylcholine; D007073:Immunoglobulin E; D002794:Choline