Anti-Lsa. Case study of an antibody to a low-incidence antigen.
An antibody to the low-incidence antigen Lsa (Lewis II) was discovered during routine pre-operative antibody screening of an 87-year-old white man. This example of anti-Lsa reacted only in the indirect antiglobulin test. The antibody did not react with Ls(a+) red cells treated with either ficin or papain. Treatment of the serum with 2-mercaptoethanol did not reduce the reactivity of the antibody. No antibody activity had been detected during previous hospital admissions.
D000368:Aged; D000937:Antigen-Antibody Reactions; D001789:Blood Group Antigens / Q000276:immunology*; D003298:Coombs Test; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D008297:Male; D065227:Transfusion Reaction
D001789:Blood Group Antigens; D007518:Isoantibodies