Effects of josamycin on polymorphonuclear leucocyte chemotaxis.
The effects of josamycin on the chemotactic response of blood polymorphonuclear leucocytes were studied. After oral administration of 2 g/day or 50 mg/kg/day for five days in man and rats respectively, polymorphonuclear chemotaxis was reduced by 20%. After in-vitro incubation with 10 mg/l josamycin chemotaxis was unaltered, whereas a 15% decrease was noted with 25 mg/l josamycin. These data suggest that josamycin is unlikely to severely impair chemotaxis in patients.
D000328:Adult; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D007933:Leucomycins / Q000494:pharmacology*; D008297:Male; D009504:Neutrophils / Q000187:drug effects*
D007933:Leucomycins