High-dose, brief-duration intravenous infusion of streptokinase in acute myocardial infarction: description of effects in the circulation.
The effects in the circulating blood of a 1-hour intravenous infusion of 1.5 X 10(6) units of streptokinase (SK) were measured during the subsequent 24-hour period in 7 patients with acute myocardial infarction. At the end of the infusion, the activator activity, expressed in SK units, averaged 65 U/ml, all of the plasminogen had disappeared, only a small amount of free plasmin was still present and functionally active alpha 2 antiplasmin had been reduced to 21% of the preinfusion level. All of the native fibrinogen had been degraded and the thrombin-coagulable protein was composed entirely of fragment X species, but the circulating plasma also contained significant amounts of the more extensively degraded fragments Y, D and E. The biologic half-life of the SK-induced activator activity was 23 minutes and that of the fibrinogen degradation products was 6.3 hours. The lytic effects persisted for 4 hours before any signs of recovery from the hemostatic defect were evident; considerable recovery was present at 25 hours.
D005338:Fibrin Fibrinogen Degradation Products / Q000097:blood; D006801:Humans; D007263:Infusions, Parenteral; D009203:Myocardial Infarction / Q000188:drug therapy*; D010958:Plasminogen / Q000097:blood; D013300:Streptokinase / Q000008:administration & dosage* / Q000627:therapeutic use; D000979:alpha-2-Antiplasmin / Q000097:blood
D005338:Fibrin Fibrinogen Degradation Products; D000979:alpha-2-Antiplasmin; D010958:Plasminogen; D013300:Streptokinase