Hemoglobin Hammersmith as the cause of severe hemolytic anemia in a Chinese girl.
Hemoglobin Hammersmith, a rare unstable hemoglobin, was diagnosed in a 4-year-old Chinese girl living in Los Angeles. She presented with the typical manifestations of this disorder, including neonatal hyperbilirubinemia, followed by increasing hepatosplenomegaly, jaundice, bilirubinuria, and a severe hemolytic anemia exacerbated by mild infections. The most prominent manifestations of the peripheral smear were polychromasia, normoblastemia, and basophilic stippling. The diagnosis was confirmed by several techniques.
D000596:Amino Acids / Q000032:analysis; D000745:Anemia, Hemolytic, Congenital / Q000209:etiology*; D044466:Asian People; D005260:Female; D006455:Hemoglobins, Abnormal / Q000032:analysis*; D006801:Humans; D007223:Infant
D000596:Amino Acids; D006455:Hemoglobins, Abnormal; C011478:hemoglobin Hammersmith