[Effect of the induction and inhibition of liver monooxygenases on the toxic and therapeutic action of vincristine].
The influence of phenobarbital and ziksorin, liver monooxygenase inductors and the influence of inhibitor SKF 525-A on the toxic and therapeutic effects of vincristine were studied on CBA and C57Bl mice (with hemoblastosis La or intact). It was shown that acute toxicity and therapeutic activity of vincristine lowered on induction of the liver monooxygenases, whereas inhibition of this enzymatic system resulted in increased toxicity and lowered therapeutic activity of vincristine. The possible use of these results in treatment of cancer patients is discussed.
D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D007942:Leukemia, Experimental / Q000188:drug therapy; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010105:Oxygenases / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D010634:Phenobarbital / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D013997:Time Factors; D014750:Vincristine / Q000627:therapeutic use / Q000633:toxicity*
D001559:Benzhydryl Compounds; D014750:Vincristine; D011335:Proadifen; D010105:Oxygenases; C016914:flumecinol; D010634:Phenobarbital
Vliianie induktsii i ingibirovaniia monooksigenaz pecheni na toksicheskoe i lechebnoe deĭstvie vinkristina.