Paracoccidioidomycosis case report: cure with amphotericin B and triple sulfa.
A man developed paracoccidioidomycosis with non-productive cough and changes on chest roentgenogram one year following agricultural work in Ecuador. Oropharyngeal and nasal lesions developed 2 years later. This chronic fungal infection is typically difficult to cure, and relapses are common. After treatment with 2.5 g of amphotericin B and a 3-year course of triple sulfa, our patient remained free of disease during 12 years of follow-up.
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D004484:Ecuador; D006801:Humans; D008297:Male; D010228:Paracoccidioides / Q000187:drug effects; D010229:Paracoccidioidomycosis / Q000188:drug therapy* / Q000473:pathology; D011647:Puerto Rico / Q000208:ethnology; D013411:Sulfadiazine / Q000627:therapeutic use*; D013416:Sulfamerazine / Q000627:therapeutic use*; D013418:Sulfamethazine / Q000627:therapeutic use*; D014768:Virginia; D000096926:Benzenesulfonamides
D000666:Amphotericin B; D004338:Drug Combinations; D013411:Sulfadiazine; D013416:Sulfamerazine; D013418:Sulfamethazine; C014873:trisulfapyrimidine; D000096926:Benzenesulfonamides