A comparison of myosin light chain subunits in the atria and ventricles of mammals.
An SDS-electrophoretic comparison of atrial and ventricular myosin light chain isotypes was performed in mouse, rat, rabbit, dog, pig, rhesus monkey, baboon, human and cow heart. Light chains 1 and 2 in atria and ventricles differed in all species with the possible exception of the rhesus monkey. Relative migration of atrial and ventricular LC-2 isotypes was similar in all species but LC-1 isotypes varied in relative migration rates suggesting increased primary sequence heterogeneity. Order of migration was VLC-1 less than ALC-1 less than ALC-2 less than VLC-2 in mouse, rat, rabbit, dog, baboon and cow and ALC-1 less than VLC-1 less than ALC-2 less than VLC-2 in pig and human heart. No obvious relationship existed between electrophoretic pattern and phylogenetic evolution.
D000818:Animals; D002417:Cattle; D004285:Dogs; D004591:Electrophoresis, Polyacrylamide Gel; D006325:Heart Atria / Q000032:analysis; D006352:Heart Ventricles / Q000032:analysis; D006801:Humans; D008253:Macaca mulatta; D051379:Mice; D009206:Myocardium / Q000032:analysis*; D015879:Myosin Subfragments; D009218:Myosins / Q000032:analysis*; D009928:Organ Specificity; D010215:Papio; D010446:Peptide Fragments / Q000032:analysis*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013552:Swine
D015879:Myosin Subfragments; D010446:Peptide Fragments; D009218:Myosins