Indium 111-labeled platelet kinetic studies and platelet-associated IgG in hairy cell leukemia.
In order to study the pathogenesis of thrombocytopenia in patients with hairy cell leukemia (HCL), levels of platelet-associated IgG (PAIgG), platelet life span (MLS), and the sequestration site of autologous 111In-labeled platelets were measured in nine patients with HCL. Splenectomized patients (n = 4) had a higher platelet count (x = 122.5 X 10(9)/l; range, 80-190 X 10(9)/l) as well as higher levels of PAIgG (x = 10.7%; range, 5.8-16.9%), than nonsplenectomized patients (platelets x = 76 X 10(9)/l, range 40-100 X 10(9)/l; PAIgG x = 3.2%, range 2.2-4.2%). A normal recovery of 111In-labeled platelets was found in splenectomized patients, whereas a very low recovery was observed in the nonsplenectomized group (x = 70.2%, range, 50-82.5%, versus x = 22.4%, range, 15-28.2%). The MLS was borderline normal in all patients. The site of sequestration was the spleen in nonsplenectomized patients. The low recovery of 111In-labeled platelets in nonsplenectomized patients suggests "hypersplenism" with pooling as a major cause of thrombocytopenia, in addition to impaired thrombocytopoiesis and possible immune-mediated platelet destruction.
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000276:immunology* / Q000473:pathology; D002455:Cell Division; D002470:Cell Survival; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007204:Indium; D007943:Leukemia, Hairy Cell / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011868:Radioisotopes; D013156:Splenectomy
D007074:Immunoglobulin G; D011868:Radioisotopes; D007204:Indium