title: [Use of the dexamethasone test in the differential diagnosis of depressive states].
abstract: The dexamethasone suppression test (DST) was conducted in 194 patients. Criteria of the DST estimation included the degree of suppression of 1-HOCS and the post-dexamethasone levels of HOCS. The results of the DST were correlated with the efficacy of the subsequent therapy. The test evidenced pathology in 79% of patients with the preliminary diagnosis of "endogenous depression" and in 94.5% of those patients of this group who were later successfully treated with antidepressants. In patients showing some response to anxiolytics the DST was abnormal in 40%. In 37 patients with anxiety depression the DST was combined with the diazepam test. The results permitted reliable differentiation between "endogenic depression with anxiety" and "endogenic anxiety with a depressive mood" and the prognosis. In cases of reactive depression the DST was abnormal only in 12% of patients. Both criteria of the DST assessment are compared, and the percentage of suppression is considered as preferable.
mesh_terms: D015062:11-Hydroxycorticosteroids / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001007:Anxiety / Q000175:diagnosis; D001714:Bipolar Disorder / Q000175:diagnosis*; D003863:Depression / Q000175:diagnosis*; D003866:Depressive Disorder / Q000175:diagnosis*; D003865:Major Depressive Disorder / Q000175:diagnosis; D003907:Dexamethasone; D003937:Diagnosis, Differential; D003975:Diazepam; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000175:diagnosis; D012559:Schizophrenia / Q000175:diagnosis
chemical_list: D015062:11-Hydroxycorticosteroids; D003907:Dexamethasone; D003975:Diazepam; D006854:Hydrocortisone
vernacular_title: Primenenie deksametazonovogo testa dlia differentsial'noĭ diagnostiki depressivnykh sostoianiĭ.