[Action of natural and synthetic antioxidants on the electrical parameters and stability of natural and artificial membranes].
The effect of antioxidants alpha-tocopherol and ionol on membranes of human red cells and bilayer lipid membrane (BLM) from azolektin has been studied. Ionol at concentration 4-10 mM induces the hemolysis of erythrocytes, the cells form changes are observed at concentration 2 mM alpha-tocopherol doesn't show the hemolytic properties at concentration 23 mM. The ionol concentration 1 mM doesn't change the form of the cells, but influence the passive electric parameters: the capacity (Cs) of erythrocytic membrane increases and the intracellular conductance (chi i) decreases. Tocopherol (3 mM) induces the decrease both Cs and chi i. The fast increase of membrane conductance is almost immediately registered on one side of BLM at addition of ionol (0,2-0,4 g/ml). Phosphatidylionol synthesized from ionol and contining the acyl chains C15H31 and C17H35 doesn't influence the electrical properties of BLM.
D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D004553:Electric Conductivity; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000502:physiology; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007501:Iron / Q000494:pharmacology; D008051:Lipid Bilayers / Q000378:metabolism; D008560:Membrane Fluidity / Q000187:drug effects*; D008567:Membranes, Artificial; D009997:Osmotic Pressure; D010713:Phosphatidylcholines; D010743:Phospholipids / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D010743:Phospholipids; D014810:Vitamin E; D002084:Butylated Hydroxytoluene; C024990:asolectin; D007501:Iron; D001205:Ascorbic Acid
Izuchenie deĭstviia prirodnykh i sinteticheskikh antioksidantov na élektricheskie parametry i ustoĭchivost' prirodnykh i iskusstvennykh.