Pulmonary dysfunction associated with streptokinase therapy.
A 66-year-old lower-extremity amputee with an acute femoral artery occlusion was treated with low-dose (10000 units/h) percutaneous constant-infusion streptokinase. At 48 hours after initiation of therapy, the patient experienced adult respiratory distress syndrome and died. A postmortem examination confirmed the diagnosis; laboratory studies reflected an increased level of fibrinolytic split products, thrombocytopenia, and a low level of fibrinogen.
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000188:drug therapy; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D007083:Iliac Artery; D007261:Infusions, Intra-Arterial; D008297:Male; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000139:chemically induced*; D013300:Streptokinase / Q000008:administration & dosage / Q000009:adverse effects*
D005338:Fibrin Fibrinogen Degradation Products; D013300:Streptokinase