Effect of sulpiride on vigilance in healthy subjects.
The effects of the antipsychotic drug sulpiride on vigilance, as measured by choice reaction time and critical flicker fusion, and on heart-rate and skin conductance, were studied in healthy volunteers (n = 6). The measurements were carried out 4 and 28 h after oral and i.v. administration of 100 mg sulpiride and during placebo condition. None of the tests or measurements showed statistically significant differences between the placebo and the active drug condition. The results were related to corresponding serum concentrations of sulpiride, the half-life elimination and the total amount of sulpiride found in the blood. No consistent trends in effects were observed. The results were interpreted as indicating minimal or no effects of sulpiride on the above measures of vigilance and autonomic activation.
D000284:Administration, Oral; D000328:Adult; D001143:Arousal / Q000187:drug effects*; D005260:Female; D005425:Flicker Fusion / Q000187:drug effects; D005712:Galvanic Skin Response / Q000187:drug effects; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D013469:Sulpiride / Q000008:administration & dosage / Q000494:pharmacology*
D013469:Sulpiride