title: Analgesic and gastrointestinal effects of nalbuphine--a comparison with pethidine.
abstract: A double-blind comparison of some analgesic and gastrointestinal effects of nalbuphine and pethidine was performed in 28 women undergoing laparoscopic sterilisation. The opioid was given as an initial loading dose prior to the induction of general anaesthesia and further doses were given on demand in the postoperative period to achieve and maintain adequate pain relief. Gastric emptying in the immediate postoperative period was also assessed in each patient by measuring the rate of absorption of orally administered paracetamol. Nalbuphine was equally effective as pethidine as a postoperative analgesic, but may have been a less effective supplement to anaesthesia in the doses used in this study. Gastric emptying was profoundly depressed in all patients irrespective of which analgesic was used.
mesh_terms: D000042:Absorption; D000082:Acetaminophen / Q000097:blood; D000328:Adult; D000818:Animals; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008614:Meperidine / Q000009:adverse effects / Q000627:therapeutic use*; D009019:Morphinans / Q000627:therapeutic use*; D009266:Nalbuphine / Q000009:adverse effects / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*; D011897:Random Allocation; D014839:Vomiting / Q000139:chemically induced
chemical_list: D009019:Morphinans; D000082:Acetaminophen; D008614:Meperidine; D009266:Nalbuphine