[Basic study on human interferon-beta: Part II. Anticellular effect].
The anticellular effect of human interferon-beta (IFN-beta, MR-21) was examined in vitro. IFN-beta had a wide anticellular spectrum in proliferation inhibition assay. Of 67 human cell lines including 62 tumor-originated cell lines, 51 were sensitive to IFN-beta (IC50 less than 1,000 IU/ml) while 16 including normal diploid cells were resistant (IC50 greater than or equal to 1,000 IU/ml). These anticellular effects were reversible and there was no relationship between the origins of tumor cell lines and their sensitivity to IFN-beta. IFN-beta induced not only proliferation inhibition but also cytotoxicity in several cell lines. It was suggested that the mode of anticellular effects of IFN-beta was mainly time-dependent.
D002452:Cell Count; D002455:Cell Division; D002460:Cell Line; D002470:Cell Survival; D002478:Cells, Cultured; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D009369:Neoplasms / Q000473:pathology*
D007370:Interferon Type I