Interdonor incompatibility due to anti-Kell antibody undetectable by automated antibody screening.
A unit of whole donor blood, the plasma of which contained anti-Kell antibody, was transfused into a Kell-negative patient who had received a unit of Kell-positive blood 4 weeks previously. A haemolytic transfusion reaction ensued. The antibody had gone undetected in routine automated screening of the donor blood. Automated antibody detection techniques do not offer reliable detection of anti-Kell antibodies.
D001789:Blood Group Antigens / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000209:etiology*; D001788:Blood Grouping and Crossmatching / Q000295:instrumentation; D001803:Blood Transfusion / Q000592:standards; D005188:False Negative Reactions; D005260:Female; D006461:Hemolysis; D006801:Humans; D007116:Immunization, Passive; D007518:Isoantibodies / Q000008:administration & dosage / Q000032:analysis / Q000276:immunology*; D007626:Kell Blood-Group System / Q000276:immunology*; D065227:Transfusion Reaction
D001789:Blood Group Antigens; D007518:Isoantibodies; D007626:Kell Blood-Group System