[Comparison of the bioavailability of two diazepam preparations. Clinical comparison between a new commercial preparation and a standard preparation after oral and intramuscular administration].
The following pharmacokinetic study was aimed at a comparison of the bioavailability of two different preparations of diazepam (Gewacalm and a further wellknown formulation). 40 healthy volunteers were subjected to a cross-over design in which plasma levels of diazepam were assayed after oral and intramuscular application of 10 mg of a preparation. In the comparison (N = 30) of oral bioavailability (rate and completeness of enteral absorption) no statistical difference between both preparations was observed. In the study of intramuscular bioavailability (N = 10), a trend of quicker and more complete resorption of Gewacalm was of statistical significance (p less than 0.05), however, because of the small number of subjects tested in the intramuscular study a replication study is advisable.
D000284:Administration, Oral; D001682:Biological Availability; D003975:Diazepam / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007273:Injections, Intramuscular; D007700:Kinetics; D008297:Male
D003975:Diazepam
Vergleich der Bioverfügbarkeit von zwei Diazepam-Zubereitungen. Klinische Vergleichsstudie zwischen einer neuen Handelszubereitung und einem Standardpräparat nach oraler und intramuskulärer Applikation.