[Analysis of the number of normochromic erythrocytes with micronuclei in the peripheral blood of mice as a method of detecting mutagens].
Cytogenic damages both in the bone marrow (5.5-fold increase in the number of cells with chromosomal aberrations) and in the peripheral blood of mice (4.5-fold increase in the frequency of micronuclear polychromatic erythrocytes and 3-fold rise in the number of micronuclear normochromic erythrocytes, as compared to the control) have been observed after a two-week administration of 0.01% cyclophosphamide with drinking water. The micronuclear test on mature erythrocytes from peripheral blood of mice can be an effective method for the identification of mutagenic properties of the factor under study during its long-term action.
D000818:Animals; D002869:Chromosome Aberrations; D004912:Erythrocytes / Q000648:ultrastructure; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests / Q000379:methods*
Analiz chastoty normokhromnykh éritrotsitov s mikroiadrami v perifericheskoĭ krovi mysheĭ kak metod vyiavleniia mutagenov.