Pyrrolnitrin analogues. XII. Synthesis and biological activity of some pyrazole carboxylic acids.
Some 1,5-diaryl-, 1-aryl-5-(2-nitrobenzyl)-3-methylpyraloze-4-carboxylic acids and some of their 4-morpholino- and 4-N-methylpiperazino amides are prepared and tested as antibacterial agents. None of the tested compounds shows any noteworthy antimicrobial activity. The results are discussed and compared with the previously published results for other similarly structured compounds.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D011764:Pyrrolnitrin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011764:Pyrrolnitrin