Antibodies to liposomes, phospholipids and phosphate esters.
Polyclonal and monoclonal antibodies to liposomes having various phospholipid compositions have been produced. Binding of the anti-lipid bilayer antibodies is influenced both by the chemical composition and the physical state of the liposomal lipids. The antibodies to liposomes have a 'subsite' in the binding site that recognizes small soluble phosphorylated haptens such as nucleotides (e.g., ATP). The capacity of anti-liposome antibodies to bind to phosphate is also shared by antibodies to numerous other substances, including lipid A from Gram-negative bacterial lipopolysaccharide, cardiolipin, DNA, polynucleotides, and lipoteichoic acids from Gram-positive bacteria. Because of similarities of chemical structures between all of these molecules widespread immunological cross-reactivities are observed.
D000818:Animals; D000906:Antibodies; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex / Q000032:analysis; D002308:Cardiolipins / Q000276:immunology; D004247:DNA / Q000276:immunology; D006825:Hybridomas / Q000276:immunology; D008050:Lipid A / Q000276:immunology; D008051:Lipid Bilayers; D008070:Lipopolysaccharides / Q000276:immunology; D008081:Liposomes; D051379:Mice; D010710:Phosphates / Q000276:immunology*; D010712:Phosphatidic Acids / Q000276:immunology; D010743:Phospholipids / Q000276:immunology*; D013329:Structure-Activity Relationship; D013682:Teichoic Acids / Q000276:immunology
D000906:Antibodies; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D002308:Cardiolipins; D008050:Lipid A; D008051:Lipid Bilayers; D008070:Lipopolysaccharides; D008081:Liposomes; D010710:Phosphates; D010712:Phosphatidic Acids; D010743:Phospholipids; D013682:Teichoic Acids; C009900:lipoteichoic acid; D004247:DNA