title: The regulation of menstrual cycle and its relationship to the moon.
abstract: A synchronous relationship between the menstrual cycle and lunar rhythm was confirmed by: Investigative data: Among the 826 female volunteers with a normal menstrual cycle, aged between 16 and 25 years, a large proportion of menstruations occurred around the new moon (28.3%), while at other times during the lunar month the proportion of menstruations occurring ranged between 8.5-12.6%; the difference was significant (p less than 0.01).
  
  
  RESULTS
  The 6-hydroxymelatonin levels in the urina sanguinis of 3 female volunteers reached their zenith prior to and during menstruation, gradually declining to their nadir during ovulation. The difference in 6-hydroxymelatonin between menstruation and ovulation was significant (p less than 0.01). Two of these three volunteers had their zenith in the period of the new moon and nadir 3-4 days prior to the full moon respectively. Clinical experience: The lunar-menses-regulatory therapy in treatment of Nephropenic secondary amenorrhea revealed 4 clinical cure, 5 marked effect, 8 menogogue and 3 ineffect out of 20 cases.
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D055580:Astronomical Phenomena; D001256:Astronomy; D002855:Chromatography, Thin Layer; D005260:Female; D006801:Humans; D008550:Melatonin / Q000031:analogs & derivatives / Q000652:urine; D008597:Menstrual Cycle; D010507:Periodicity
chemical_list: D008550:Melatonin; C012365:6-hydroxymelatonin