title: Renal damage caused by heavy metals.
abstract: Studies of tubular injury and necrosis caused by heavy metals have indicated involvement by various parts of the proximal tubule. This paper describes the patterns of injury seen after administration of mercuric chloride, uranyl nitrate, and cisplatin to animal models. Studies describing a possible role of the mesangium of the renal corpuscle in proximal tubular injury are included.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D002945:Cisplatin / Q000633:toxicity; D006801:Humans; D007672:Kidney Cortex / Q000187:drug effects / Q000648:ultrastructure; D007679:Kidney Medulla / Q000187:drug effects / Q000648:ultrastructure; D008627:Mercuric Chloride / Q000633:toxicity; D008670:Metals / Q000633:toxicity*; D008854:Microscopy, Electron; D051381:Rats; D014502:Uranyl Nitrate / Q000633:toxicity
chemical_list: D008670:Metals; D014502:Uranyl Nitrate; D008627:Mercuric Chloride; D002945:Cisplatin