Reduced responsiveness of touch (SA I) receptors in the cat following close arterial infusion of neomycin.
Electrophysiological recordings were made from afferent nerve fibres supplying slowly adapting type I (SA I) cutaneous mechano-receptors in the cat during application of mechanical stimuli (20 mN constant force, 0.2 s rise time and 2 s plateau phase, every 30 s). Close arterial infusion of neomycin (2.5 mg/min for 5 min) strongly depressed the responsiveness of SA I receptors. A direct effect on the receptor is thought to be the mode of action.
D000818:Animals; D002415:Cats; D003864:Depression, Chemical; D005260:Female; D008297:Male; D008465:Mechanoreceptors / Q000187:drug effects*; D009355:Neomycin / Q000494:pharmacology*; D012867:Skin / Q000294:innervation*; D014110:Touch / Q000187:drug effects*
D009355:Neomycin