[Dynamics of the chromosomal damages to Ehrlich ascitic cancer and bone marrow cells of mice by the antitumor preparation dimetinur].
The dimetinur effect upon chromosomes of the Ehrlich ascite carcinoma and bone marrow cell populations was analyzed by the cytogenetic method for 10 days after i.p. and i. v. drug administration in doses from 50 to 150 mg/kg. Kinetic regularities of changes in a fraction of cells with chromosome breakages and in the number of broken chromosomes per cell as well as "dose-effect" relations are determined. A linear correlation is established between the level of residual chromosome damages in a population of tumour cells and the coefficient of activity chi* characterizing the antitumour effect of dimetinur. Selectivity of the dimetinur mutagenic action expressed as a more deep and prolonged damage of the genetic system of tumour cells as compared to bone marrow cells of tumour-bearing animals is shown under conditions of a pronounced therapeutic activity.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000648:ultrastructure; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008770:Methylnitrosourea / Q000031:analogs & derivatives*; D051379:Mice; D009368:Neoplasm Transplantation; D009607:Nitrosourea Compounds / Q000627:therapeutic use* / Q000633:toxicity; D013997:Time Factors
D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds; C001049:N,N'-dimethylnitrosourea; D008770:Methylnitrosourea
Dinamika povrezhdeniĭ khromosom kletok astsitnogo raka Erlikha i kostnogo mozga mysheĭ protivoopukholevym preparatom dimetinur.