Effect of glyzophrol on fertility of female black rats (Rattus rattus).
A mild degree of fibrosis, dilatation of blood vessels, haemorrhagic reactions in a few places, granulosa cells in the stroma and no effect on the maturation process of follicles were observed in the ovaries of 20 mg/kg of Glyzophrol treated rats. After 60 mg/kg of Glyzophrol treatment, the ovary revealed a reduction in the number of follicles, degenerative changes in existing follicles, frequent proliferation of granulosa cells and fibrosis in the stroma, along with karyorrhexis, karyolysis and pyknosis in the nuclei. Haemorrhage and dilated blood vessels in the stroma were well marked, suggesting that ovarian vasculature was affected by Glyzophrol. The ovary exhibited an increase in the activity of acid phosphatase after Glyzophrol treatment. Intense alkaline phosphatase activity was observed in the entire ovarian tissue after Glyzophrol treatment.
D000135:Acid Phosphatase / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D002629:Chemosterilants / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006470:Hemorrhage / Q000139:chemically induced; D010049:Ovarian Diseases / Q000139:chemically induced; D006080:Ovarian Follicle / Q000187:drug effects; D010053:Ovary / Q000098:blood supply / Q000187:drug effects / Q000201:enzymology; D051381:Rats
D002629:Chemosterilants; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase