Prediction of lithogenic character of human bile by a quaternary system.
The lithogenic character of human gallbladder bile was investigated by a mathematical model on the basis of a clinical data set. Each bile was described by means of the quaternary system bile salts--phospholipids--free fatty acids--cholesterol. Reporting a set of bile samples on the tetrahedron of concentrations, a clear separation emerged between the control bile, the bile from patients with gallstones, and the bile of subjects with gallbladder dyskinesia. This group was characterized by a largely increased content of free fatty acids.
D000328:Adult; D001646:Bile / Q000032:analysis*; D001647:Bile Acids and Salts / Q000032:analysis; D002769:Cholelithiasis / Q000378:metabolism*; D002784:Cholesterol / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000032:analysis; D006801:Humans; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D008954:Models, Biological; D010743:Phospholipids / Q000032:analysis
D001647:Bile Acids and Salts; D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D002784:Cholesterol