[Characteristics of induced aminopyrine N-demethylase].
The study of the inducing effect of phenobarbital on the activity of N-demethylase of aminopyrine in the rat liver microsomes revealed the correlation of the rate of enzymic reaction with the changes in the maximum binding of aminopyrine by cytochrome P-450 rather than with the content of hemoprotein itself. The comparison of the activity of N-demethylation of aminopyrine in control and phenobarbital-induced rats showed the quantitative correspondence of the yield of products of the reaction--formaldehyde in the liver microsomes and 4-aminoantipyrine in the urine samples. Self-induction of N-demethylating activity at repeated aminopyrine administration to rats and the dose dependence of this phenomenon were found.
D000633:Aminopyrine N-Demethylase / Q000096:biosynthesis*; D000675:Ampyrone / Q000378:metabolism; D000818:Animals; D000906:Antibodies; D001711:Biotransformation / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000276:immunology / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000906:Antibodies; D000675:Ampyrone; D003577:Cytochrome P-450 Enzyme System; D000633:Aminopyrine N-Demethylase; D010634:Phenobarbital
Kharakteristika indutsirovannoĭ N-demetilazy aminopirina.