title: [Action of phytoecdysteroids on the bile-secretory function of the normal liver and in experimental hepatitis].
abstract: Phytoecdysteroids from Rhaponticum carthemoides (Willd) Iljin and Ajuga turkestanica (Rgl.) Brig in a dose of 5 mg/kg per os markedly stimulate the bile secretion in normal rats treated with single (cyasterone) and 7-day-long (ecdysterone, cyasterone) administration. The chemical composition of the bile is significantly improved because of increased levels of bile acids and bilirubin and a decreased cholesterol content. Phytoecdysteroids (ecdysterone) exert more beneficial effect on the parameters under study in rats with toxic hepatitis induced by heliotrine.
mesh_terms: D000818:Animals; D001646:Bile / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D055598:Chemical Phenomena; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000503:physiopathology; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004441:Ecdysterone / Q000494:pharmacology / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010946:Plants, Medicinal; D011763:Pyrrolizidine Alkaloids / Q000633:toxicity; D051381:Rats; D013265:Stigmasterol / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D011763:Pyrrolizidine Alkaloids; C002082:cyasterone; D004441:Ecdysterone; D013265:Stigmasterol; C010178:heliotrine
vernacular_title: Deĭstvie fitoékdisteroidov na zhelcheotdelitel'nuiu funktsiiu pecheni v norme i pri éksperimental'nom gepatite.