[The ratio of protein and carbohydrate components of proteoglycans from normal and degenerative articular cartilage].
The protein/uronic acid ratio in monomers and aggregates of proteoglycans in the human articular cartilage is investigated. It is shown that for the first two hours of cartilage extraction by isotonic solution proteoglycans with the low concentration of chondroitin sulphate are mainly removed; in the process of the subsequent extraction proteoglycans with a large amount of chondroitin sulphate; the quantity of chondroitin sulphate in the molecule does not effect the ability of proteoglycans to aggregation. The protein/uronic acid ratio increases in cartilage proteoglycans with aging and in the process of cartilage degeneration due to a decrease in the amount of the carbohydrate part of the molecule.
D000328:Adult; D000368:Aged; D002241:Carbohydrates / Q000032:analysis*; D002357:Cartilage Diseases / Q000378:metabolism* / Q000473:pathology; D002358:Cartilage, Articular / Q000032:analysis* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D011506:Proteins / Q000032:analysis*; D011509:Proteoglycans / Q000032:analysis*; D014574:Uronic Acids / Q000032:analysis
D002241:Carbohydrates; D011506:Proteins; D011509:Proteoglycans; D014574:Uronic Acids
Sootnoshenie belkovogo i uglevodnogo komponentov proteoglikanov neizmenennogo i degenerativno izmenennogo sustavnogo khriashcha.