Inflammatory fibroid polyp of the stomach.
Fourteen cases of inflammatory fibroid polyp of the stomach were studied in terms of immunohistochemistry and ultrastructure. They occurred as polypoid lesions in the antrum, except for two found in the body of the stomach. Out of the 14 cases, two were found to be multiple and the remainder solitary. In all but one lesion, the mucosal layer was involved and six lesions were entirely localized within the mucosal layer, suggesting that inflammatory fibroid polyps of the stomach originate in the mucosal layer. Neither S100 protein, factor VIII-related antigen, alpha 1-antitrypsin nor lysozymes were found in the cytoplasm of the proliferating cells. The ultrastructures of the proliferating cells were fibroblastic rather than neurogenic, angiogenic, or myofibroblastic. These findings suggest that the cells are fibroblasts, though the possibility that they are facultative fibroblasts remains. An interesting observation made with electron microscope was the infection of micro-organisms similar to mycoplasma. This seems to deserve further investigation as a possible etiologic factor of the disease.
D000328:Adult; D000368:Aged; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005350:Fibroma / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D007249:Inflammation / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*