Pentoxifylline: cerebral blood flow and glucose utilization in conscious spontaneously hypertensive rats.
Pentoxifylline, 0.30 mg/kg/min, significantly reduced cerebral blood flow by 10-44% in 19 of 23 regions studied in conscious spontaneously hypertensive rats. Bilateral ligation of the common carotid arteries reduced cerebral blood flow to 24-46% of resting values in 20 structures; a further reduction to 10-27% of resting values was seen after pentoxifylline in 10 cortical or subcortical structures. Thus, in conscious hypertensive rats, there is no evidence that pentoxifylline redistributes blood flow from normal to low flow brain regions. Pentoxifylline did not reduce the metabolic rate of glucose.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002339:Carotid Arteries / Q000601:surgery; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology*; D008026:Ligation; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D013805:Theobromine / Q000031:analogs & derivatives*
D005947:Glucose; D013805:Theobromine; D010431:Pentoxifylline