The effects of flavonoids on human lymphocyte proliferative responses.
Flavonoids reversibly inhibit lymphocyte proliferative responses to phytomitogens, soluble antigens and phorbol esters by blocking an early event or events that follow stimulation. Quercetin and tangeretin inhibit thymidine transport in stimulated lymphocytes. These flavonoids reversibly inhibit antigen processing by monocytes and inhibit the expression of class II histocompatibility (DR) antigens in PBM cells.
D000938:Antigen-Presenting Cells / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011794:Quercetin / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D005419:Flavonoids; D010835:Phytohemagglutinins; D014316:Tritium; D004247:DNA; D011794:Quercetin; D013936:Thymidine