Antibiotic-associated pseudomembranous colitis as cause of intestinal obstruction in a five-day-old newborn.
The case report is presented of a newborn that developed pseudomembranous colitis and intestinal obstruction after antibiotic therapy with cefoxitin and gentamicin in the first week of life. At laparotomy on the fifth day a complete obliteration of the descending colon by pseudomembranes was encountered. After resection of the diseased segment the recovery was uneventful. We believe this case is the first to be published of antibiotic-associated pseudomembranous colitis causing intestinal obstruction.
D002440:Cefoxitin / Q000009:adverse effects* / Q000627:therapeutic use; D003106:Colon / Q000473:pathology; D004359:Drug Therapy, Combination; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced* / Q000473:pathology; D005839:Gentamicins / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007415:Intestinal Obstruction / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy*
D005839:Gentamicins; D002440:Cefoxitin