The fate of administered purines in the Dalmatian coach hound.
The fate of radioactively labelled purines was examined in the Dalmatian Coach Hound after oral and intravenous administration. The incomplete intestinal absorption of urate, delayed conversion of urate to allantoin and the increased renal output and clearance of urate found in the Dalmatian Coach Hound when compared with the non-Dalmatian were consistent with a generalized defect in the transport of urate across cell membranes.
D000284:Administration, Oral; D000818:Animals; D002250:Carbon Radioisotopes; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004285:Dogs / Q000378:metabolism*; D005260:Female; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000008:administration & dosage / Q000378:metabolism*; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008297:Male; D013045:Species Specificity; D014316:Tritium; D014527:Uric Acid / Q000008:administration & dosage / Q000378:metabolism*
D002250:Carbon Radioisotopes; D007042:Hypoxanthines; D014316:Tritium; D014527:Uric Acid; D019271:Hypoxanthine