title: Synthesis of some new hydrazone derivatives as biologically active agents.
abstract: A series of [4-(6H/bromo-4-oxo-2-phenyl-3(4H)-quinazolinyl)phenoxy]acetic acid (1,2-dihydro-1-H/methyl-2-oxo-3H-indol-3-ylidene)hydrazides (VII1-16) were synthesised by condensing 1-H/methyl-5-substituted indoline-2,3-diones with [4-(6H/bromo-4-oxo-2-phenyl-3(4H)-quinazolinyl) phenoxy]acetic acid hydrazides (IV1-2) which in turn were obtained by reacting ethyl [4-(6H/bromo-4-oxo-2-phenyl-3(4H)-quinazolinyl)phenoxy]acetates (III1-2) with hydrazine hydrate. All the synthesised compounds (VIII1-16) were screened for their antibacterial, acetylcholinesterase enzyme inhibitory and antiviral activities.
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis; D001419:Bacteria / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared
chemical_list: D000998:Antiviral Agents; D002800:Cholinesterase Inhibitors; D006835:Hydrazones