Cutaneous myxomas. A major component of the complex of myxomas, spotty pigmentation, and endocrine overactivity.
Cutaneous myxoma(s) occurred in 22 (54%) of 41 patients with the complex of myxomas, spotty pigmentation, and endocrine overactivity. Of the 16 patients who had cardiac myxoma(s), the cutaneous tumor(s) was (were) detected in 13 (81%) of them prior to diagnosis of the cardiac neoplasm. Thus, the cutaneous tumor may herald a potentially fatal cardiac neoplasm (and other important conditions as well). Clinical features of the lesion were as follows: early appearance (mean age, 18 years); multicentricity (71% of patients); small size (usually less than 1 cm in diameter); widespread distribution but with predilection for certain sites (eyelids, ears, nipples); and tendency for recurrence. Pathologic features included the following: location in dermis, subcutis, or both; sharp circumscription (sometimes encapsulation); hypocellularity; abundant myxoid stroma; prominent capillaries; lobulation (larger lesions); and occasional presence of an epithelial component.
D000293:Adolescent; D000328:Adult; D003094:Collagen / Q000032:analysis; D004700:Endocrine System Diseases / Q000235:genetics* / Q000473:pathology; D005260:Female; D006338:Heart Neoplasms / Q000235:genetics; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D009232:Myxoma / Q000235:genetics* / Q000473:pathology; D010859:Pigmentation Disorders / Q000235:genetics* / Q000473:pathology; D012155:Reticulin / Q000032:analysis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology; D013577:Syndrome
D012155:Reticulin; D003094:Collagen