[Comparative study of 2',3'-O-isopropylidene adenosine and adenosine transformation in rat liver homogenates].
Transformation of synthesized 2',3'-O-isopropylidene adenosine was studied in comparison with adenosine in rat liver homogenates. It is stated that 2',3'-O-isopropylidene adenosine is subjected to deamination similar to adenosine but less intensively. Due to deamination 2',3'-O-isopropylidene inosine is formed from 2',3'-O-isopropylidene adenosine. It is shown that under conditions of the conducted experiments enzymic splitting of the isopropylidene grouping from the preparation does not occur; this substrate contrary to adenosine does not split under the effect of purine nucleoside phosphorylase.
D000241:Adenosine / Q000031:analogs & derivatives* / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D051381:Rats
C014626:2',3'-isopropylideneadenosine; D000241:Adenosine
Sravnitel'noe issledovanie prevrashcheniia 2',3'-O-isopropilidenadenozina i adenozina v gomogenatakh pecheni krys.