title: A profile of cognitive deficit in females from fragile X families.
abstract: Fragile X, a recently discovered X-linked syndrome, is usually associated with mental retardation in affected males. Less consistent findings have been described for females. neuropsychological evaluation of seven nonretarded females from fragile X families suggested a characteristic profile: on Wechsler IQ tests, a positive Verbal-Performance score difference and lower subtest scaled scores on Arithmetic, Digit Span, Block Design, and Object Assembly; on the Wide Range Achievement Test, a lower score on Arithmetic than on Reading or Spelling; and on the Benton Visual Retention Test, defective recall. These results suggest the existence of X-linked learning disability in females.
mesh_terms: D000124:Achievement; D000293:Adolescent; D000328:Adult; D002648:Child; D003071:Cognition; D005260:Female; D005600:Fragile X Syndrome / Q000523:psychology*; D006801:Humans; D007858:Learning; D009483:Neuropsychological Tests; D010375:Pedigree; D012153:Retention, Psychology; D012729:Sex Chromosome Aberrations / Q000523:psychology*; D014888:Wechsler Scales