The effect of glycerol on autotomy. An experimental model of neuralgia pain.
Autotomy in nerve injured rats has been put forward as an animal model in a broad range of chronic neuralgic pain. We have examined the effect of glycerol, a new and promising therapeutic agent for trigeminal neuralgia, on this animal model. A single dose of glycerol, alcohol or saline was injected directly into experimental sciatic nerve neuromas in rats via a chronically implanted cannula. Injections were made either at the time of nerve injury or 2 weeks afterwards. Both forms of glycerol treatment caused a significant reduction in autotomy behavior relative to saline. Alcohol also suppressed autotomy, but it was less effective than glycerol.
D000818:Animals; D001522:Behavior, Animal; D003714:Denervation; D004195:Disease Models, Animal; D000431:Ethanol / Q000627:therapeutic use; D005990:Glycerol / Q000627:therapeutic use*; D008297:Male; D010292:Paresthesia / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012652:Self Mutilation / Q000517:prevention & control; D014277:Trigeminal Neuralgia / Q000188:drug therapy* / Q000503:physiopathology
D000431:Ethanol; D005990:Glycerol