[Vascular and neuronal mechanisms of calcium antagonists. Significance in neurological therapy].
Calcium-channel entry blockers are drugs with different chemical properties and a common pharmacological characteristic. Calcium is very important in many physiological mechanisms and could be involved in neuronal damage following cerebral ischemia. Thus, calcium-channel blockers agents could be of interest in medical treatment of cerebrovascular diseases, headache and subarachnoid hemorrhage. Calcium-channel blockers seem to have a direct protective role against neuronal ischemic damage and/or a direct action on cerebral vessels. Some clinical experiences have suggested a protective role of nimodipine in the prevention of ischemic complications related to cerebral vasospasm after subarachnoid hemorrhage.
D001812:Blood-Brain Barrier / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000145:classification / Q000494:pharmacology* / Q000627:therapeutic use; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000517:prevention & control; D009474:Neurons / Q000187:drug effects*; D009539:Nicotinic Acids / Q000627:therapeutic use; D009553:Nimodipine; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy*
D002121:Calcium Channel Blockers; D009539:Nicotinic Acids; D009553:Nimodipine
Meccanismi vascolari e neuronali dei calcio-antagonisti. Significato in terapia neurologica.