Sulphate transport in human placental brush-border membrane vesicles: competitive inhibition by selenate.
The effect of selenate on sulphate uptake by human placental brush-border membrane vesicles has been investigated. Selenate added to the incubation medium inhibits 1 mM sulphate uptake in a dose-dependent fashion with a Ki of approx. 2.5 mM. The inhibition by selenate is competitive, suggesting that selenate and sulphate share a common transporter (an anion exchange system) which may be of particular importance for the transport of such essential trace elements to the fetus.
D001667:Binding, Competitive; D001692:Biological Transport / Q000187:drug effects; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008871:Microvilli / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D012643:Selenium / Q000378:metabolism / Q000494:pharmacology*; D013431:Sulfates / Q000378:metabolism*
D013431:Sulfates; D012643:Selenium