Pharmacokinetic study of lenampicillin (KBT-1585) in healthy volunteers.
The pharmacokinetic properties of lenampicillin (KBT-1585), a new ampicillin ester, were investigated in 41 healthy volunteers. The maximum concentration of ampicillin in serum after oral administration of 400 mg of lenampicillin was 6.5 micrograms/ml at 0.70 h, and that after a equimolar dosage of ampicillin was 2.9 micrograms/ml at 0.87 h.
D000667:Ampicillin / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000652:urine; D000900:Anti-Bacterial Agents / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004347:Drug Interactions; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D011339:Probenecid / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000667:Ampicillin; C045384:lenampicillin; D011339:Probenecid