title: Parasite-induced suppression of the immune response in Aedes aegypti by Brugia pahangi.
abstract: The melanization response against intrathoracically inoculated Brugia pahangi and Dirofilaria immitis microfilariae (mff) isolated from vertebrate host blood was evaluated in both uninfected Aedes aegypti black-eyed Liverpool strain and in mosquitoes harboring a developing B. pahangi infection. The immune response against inoculated mff of either species was significantly reduced by 28-47% in infected as compared with uninfected mosquitoes. Attempts to passively transfer this suppression factor(s) by inoculating naive mosquitoes with 0.1-0.2 microliter of hemolymph from B. pahangi-infected mosquitoes produced equivocal results. The role this parasite-induced immune suppression might play in aiding parasite survival in compatible vectors is discussed.
mesh_terms: D000330:Aedes / Q000276:immunology* / Q000378:metabolism / Q000469:parasitology; D000818:Animals; D002009:Brugia / Q000276:immunology* / Q000469:parasitology; D006458:Hemolymph / Q000276:immunology / Q000469:parasitology; D006790:Host-Parasite Interactions; D007116:Immunization, Passive; D007165:Immunosuppression Therapy; D008543:Melanins / Q000378:metabolism; D008842:Microfilariae / Q000276:immunology / Q000469:parasitology
chemical_list: D008543:Melanins