Effects of immunostimulation with OK432, coenzyme Q10, or levamisole on dimethylhydrazine-induced colonic carcinogenesis in rats.
Effects of immunostimulation with OK432, Coenzyme Q10 (Co-Q10), or levamisole on dimethylhydrazine (DMH)-induced colonic carcinogenesis were investigated in 45 Donryu-rats. The manipulation with one of these immunopotentiators did not prevent DMH-induced colonic carcinogenesis in these rats. However, the number of tumors was significantly reduced and the incidence of invasive carcinomas decreased by immunostimulation. The treatment also reduced the number of lesions with epithelial dysplasia within the flat colonic mucosa.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D001688:Biological Products / Q000627:therapeutic use*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D003067:Coenzymes; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000628:therapy*; D004127:Dimethylhydrazines; D004848:Epithelium / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects; D007978:Levamisole / Q000627:therapeutic use*; D010844:Picibanil / Q000627:therapeutic use*; D051381:Rats; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use
D001688:Biological Products; D003067:Coenzymes; D004127:Dimethylhydrazines; D014451:Ubiquinone; D007978:Levamisole; D010844:Picibanil; C024989:coenzyme Q10; D019813:1,2-Dimethylhydrazine