Neurotoxicologic examination of rats dermally exposed to 2,4-D amine for three weeks.
There was no evidence of peripheral neuropathy or other neurotoxicity in rats dermally treated with a 12% aqueous solution of the amine salt of 2,4-dichlorophenoxyacetic acid (2,4-D amine). Male and female Fischer 344 rats were treated on the skin of all four limbs with 2,4-D amine for 2 hr/day, 5 days/week, for 3 weeks. Measurements were: body weights, hindlimb grip strength, accelerating rod performance, single and paired pulse electrophysiology of the caudal and sciatic nerves, hindfoot H-reflexes, light microscopy of brain, spinal cord, sciatic nerve, tibial nerve, digital nerve, and electron microscopy of the tibial nerve. The experiment continued for up to one month postexposure. Treatment caused a weight loss in both male and female rats and caused minor skin changes during treatment in both sexes. No other treatment-related effects were found.
D015084:2,4-Dichlorophenoxyacetic Acid / Q000008:administration & dosage / Q000633:toxicity*; D000200:Action Potentials / Q000187:drug effects; D000287:Administration, Topical; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D004123:Dimethylamines / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D006181:H-Reflex / Q000187:drug effects; D008297:Male; D009048:Motor Skills / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D010525:Peripheral Nerves / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344
D004123:Dimethylamines; C037991:2,4-D amine; D015084:2,4-Dichlorophenoxyacetic Acid