Sensitivity of locally regenerated testicular vessels to cadmium.
The conditions under which capillaries and venules within the testes of most scrotum-bearing mammals become sensitive and/or resistant to cadmium are not clearly elucidated. Localized heat lesions were produced within the testes of rats to allow regrowth from surrounding Cd-sensitive vessels into the damaged areas. After 2, 4, or 8 weeks rats were given a subcutaneous injection of CdCl2 in saline (5 mg/kg) and were sacrificed 6 h later. Tissue samples were examined by both light and electron microscopy. No evidence of Cd sensitivity in regenerated vessels was present after 2 weeks, but the surrounding normal tissue did show typical Cd-related damage. By 8 weeks, vessels within the lesioned areas responded to Cd in a manner similar to those in the surrounding tissue. Newly grown testicular vessels do not demonstrate Cd sensitivity, but they develop it between 4 and 8 weeks.
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D002196:Capillaries / Q000187:drug effects / Q000502:physiology; D004351:Drug Resistance; D006358:Hot Temperature; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration; D013737:Testis / Q000098:blood supply*; D014699:Venules / Q000187:drug effects / Q000502:physiology
D002104:Cadmium