Pharmacodynamic specification and membrane stabilising action of a homologous series of silasympathomimetics.
The pharmacodynamic effect of a homologous series of aminomethyldimethyl-(methoxyphenyl)-silane derivatives have been tested on isolated guinea-pig left atria. All molecules increase the force of contraction to different degrees by a partly direct and partly indirect mechanism (measured on atria isolated from reserpine treated guinea-pigs). The positive inotropic effect is reduced by bupranolol. Furthermore the compounds show an antagonistic effect to orciprenaline. The membrane stabilising action is lowest for those compounds showing the highest inotropic effects and vice versa.
D000818:Animals; D002046:Bupranolol / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009921:Metaproterenol / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology; D012821:Silanes / Q000494:pharmacology*; D012825:Silicon / Q000494:pharmacology*; D013566:Sympathomimetics / Q000494:pharmacology*
D012821:Silanes; D013566:Sympathomimetics; D009921:Metaproterenol; D002046:Bupranolol; D012110:Reserpine; D012825:Silicon