title: Effects of medroxyprogesterone acetate on subjective arousal, arousal to erotic stimulation, and nocturnal penile tumescence in male sex offenders.
abstract: Three chronic pedophiliac sex offenders were treated individually with medroxyprogesterone acetate (MPA) over a minimum of 3 months. Genital and subjective response to erotic stimulation, nocturnal penile tumescence, self-reporting of sexual urges, and testosterone levels were recorded repeatedly throughout the study. A single-subject reversal design was used and medication was administered through a double-blind procedure. The results showed that self-report of arousal outside of a laboratory setting was unreliable as a measure of the drug effect. In a laboratory setting, however, there appeared to be a significant reduction in the report of arousal to erotic stimuli while genital arousal decreased only slightly. Reversal of these responses occurred in only one subject during a final placebo phase. Nocturnal penile tumescence was significantly decreased during MPA administration and appeared to be related to decreases in total testosterone.
mesh_terms: D000328:Adult; D001143:Arousal / Q000187:drug effects; D004311:Double-Blind Method; D004882:Erotica; D006801:Humans; D007989:Libido / Q000187:drug effects; D008297:Male; D008525:Medroxyprogesterone / Q000627:therapeutic use*; D008875:Middle Aged; D010262:Paraphilic Disorders / Q000188:drug therapy*; D010378:Pedophilia / Q000097:blood / Q000188:drug therapy*; D010410:Penile Erection / Q000187:drug effects; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D008525:Medroxyprogesterone