[Clonal structure of tumors: difference between clones based on the ability to secrete growth-regulating factors and to react to them].
Conditioned medium isolated from different clones of tumour cell culture PS-103 (sarcoma induced in CBA mouse by plastic film implantation) varied in the ability to stimulate cell proliferation in semi-solid medium. The clones differed also in their response to the medium conditioned by culture PS-103: some clones responded by increased proliferation in semi-solid medium, some were inhibited and some failed to respond.
D000818:Animals; D002455:Cell Division; D002999:Clone Cells / Q000503:physiopathology*; D006133:Growth Substances / Q000378:metabolism*; D066298:In Vitro Techniques; D051379:Mice; D008808:Mice, Inbred CBA; D012513:Sarcoma, Experimental / Q000473:pathology*
D006133:Growth Substances
Klonal'naia struktura opukholi: razlichiia mezhdu klonami po sposobnosti vydeliat' faktory, reguliruiushchie razmnozhenie, i reagirovat' na nikh.