title: [Statistical analysis of abnormal human alpha and beta globins].
abstract: Statistical treatment of data concerning the primary structure, molecular conformational stability and fitness of carriers of 123 alpha- and 211 beta-abnormal human globins is presented. The analysis of the data shows that the average number of amino acid replacements per site is 1.66 times higher for abnormal beta-globins than for alpha-globins, mainly due to prenatal stabilizing selection. The results indicate that 40% of abnormal alpha-globins are eliminated during the fetal stages of ontogenesis. Implication of the results obtained is discussed in terms of mutation rate monitoring in human populations.
mesh_terms: D000483:Alleles; D000596:Amino Acids / Q000032:analysis; D005914:Globins / Q000032:analysis / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000032:analysis / Q000235:genetics*; D006801:Humans; D009154:Mutation; D013223:Statistics as Topic
chemical_list: D000596:Amino Acids; D006455:Hemoglobins, Abnormal; D005914:Globins
vernacular_title: Statisticheskiĭ analiz anomal'nykh alpha- i beta-globinov cheloveka.