Naloxone fails to reverse hemorrhagic hypotension.
The effect of opiate antagonist therapy with naloxone on hemorrhagic shock was examined. An equivalent intravenous bolus of naloxone or normal saline had the same pressor effect in conscious, unrestrained, hypovolemic hypotensive rats. The proposal that opiate antagonists are of therapeutic value in the treatment of hemorrhage is questioned.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006470:Hemorrhage / Q000150:complications*; D007022:Hypotension / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D008297:Male; D009270:Naloxone / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology
D009270:Naloxone; D012965:Sodium Chloride