Lymph-node infarction and malignant lymphoma: a multicentre survey of European, English and American cases.
A multicentre study of 51 cases of lymph-node infarction seen in the 30-year period 1956 to 1985 was conducted in order to assess both the short- and long-term prognostic implications of the condition. In 14 cases malignant lymphoma was found synchronously with the infarct. Of the remaining 37 patients with apparently 'benign' lymph-node infarction only six showed manifestations of malignant lymphoma in the follow-up time studied (mean = 48 months; range 1-156 months). These subsequent malignant lymphomas all occurred within 2 years of the lymph-node infarction. A postal enquiry and collation of other cases in the medical literature indicates that a minority (26 of 81) have developed malignant lymphoma, and that these lymphomas, too, have all appeared within 2 years. Thorough examination of both the infarcted lymph nodes and others resected at the same time is mandatory in order to exclude concomitant or underlying malignant lymphoma. Two years after lymph-node infarction the risk of malignant lymphoma is negligible.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003238:Connective Tissue / Q000098:blood supply / Q000473:pathology; D004739:England; D005060:Europe; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007238:Infarction / Q000209:etiology / Q000473:pathology*; D008198:Lymph Nodes / Q000098:blood supply* / Q000473:pathology; D008223:Lymphoma / Q000098:blood supply* / Q000150:complications / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011379:Prognosis; D013927:Thrombosis / Q000473:pathology; D014481:United States