Patterns of mucous secretion in normal and pathological conditions of the endocervix.
20 specimens of normal endocervix, 30 of chronic cervicitis, 20 of endocervical polyps and 10 of adenocarcinomas were histochemically investigated in order to assess their mucin pattern. Diastase periodic acid-Schiff (D-PAS), Alcian blue pH 2.5 (AB), High iron-diamine (HID) and HID followed by Alcian blue pH 2.5 (HID-AB) were used. Both the superficial and glandular epithelium of the normal endocervix contained abundant amounts of neutral mucins. Generally sialomucins were scarce and predominant over sulphomucins: the latter were in some cases absent in the proliferative phase of the menstrual cycle and increased in the secretory phase. In chronic cervicitis a slight amount of sulphomucins in the residual glandular epithelium, especially in areas presenting severe inflammation, pseudoerosion, or both was observed. Nabothian cysts mainly contained sulphomucins. In the endocervical polyps, the mucin pattern was various. In adenocarcinomas mucin secretion was usually scanty and mixed with a predominance of sialomucins. Therefore resulted: the mucin pattern of the normal endocervical epithelium is related to the menstrual cycle; the histochemical evaluation of mucous secretion, presently doesn't seem to be helpful in differentiating endocervical from endometrial adenocarcinomas.
D000230:Adenocarcinoma / Q000378:metabolism; D002582:Cervix Mucus / Q000032:analysis / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008597:Menstrual Cycle; D009077:Mucins / Q000378:metabolism*; D011127:Polyps / Q000378:metabolism; D052116:Sialomucins; D002577:Uterine Cervical Diseases / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism; D002575:Uterine Cervicitis / Q000378:metabolism; D014594:Uterine Neoplasms / Q000378:metabolism
D009077:Mucins; D052116:Sialomucins; C012564:sulfomucin