Methotrexate toxicity precipitated by azapropazone.
We report an episode of bone marrow hypoplasia following the administration of azapropazone to a patient stabilized on regular methotrexate for psoriasis. A pharmacokinetic interaction is postulated.
D000328:Adult; D001032:Apazone / Q000009:adverse effects* / Q000627:therapeutic use; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000188:drug therapy; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy; D014227:Triazines / Q000009:adverse effects*
D014227:Triazines; D001032:Apazone; D008727:Methotrexate