Effect of hydralazine on intrapulmonary shunt.
We compared the acute effects of bilateral arteriovenous may be related to levels of PvO2. The hydralazine-associated (p less than .05) decrease in resistance. Mixed venous oxygen fistulas to those of hydralazine infusion on hemodynamics and pulmonary gas exchange in dogs with pulmonary edema induced by administration of oleic acid. Oleic acid significantly (p less than .01) increased intrapulmonary shunt (Qsp/Qt) and pulmonary and systemic vascular resistance, and reduced cardiac output. Once the lesion stabilized, both opening the fistula and infusing hydralazine produced a similar and significant (p less than .01) increase in cardiac output, and a significant (p less than .05) decrease in resistance. Mixed venous oxygen tension (PvO2) closely followed the changes in cardiac output; however, PaO2 did not change. Qsp/Qt significantly (p less than .01) increased with the fistulas open and with hydralazine infusion. Closure of the fistulas or bleeding the animal at the end of the experiment reversed the changes in cardiac output and Qsp/Qt. The comparable increases in cardiac output and Qsp/Qt produced by opening the fistulas or infusing hydralazine may be related to levels of PvO2. The hydralazine-associated PvO2 increase indicates that this drug increased oxygen transport to the tissues even as Qsp/Qt became larger.
D000818:Animals; D004285:Dogs; D005402:Fistula; D006439:Hemodynamics / Q000187:drug effects*; D006830:Hydralazine / Q000627:therapeutic use*; D008168:Lung / Q000502:physiology* / Q000601:surgery; D019301:Oleic Acid; D009829:Oleic Acids / Q000506:poisoning; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy*; D011659:Pulmonary Gas Exchange / Q000187:drug effects
D009829:Oleic Acids; D006830:Hydralazine; D019301:Oleic Acid