[Relation between the toxic killing of mouse small intestine enterocytes and the interval between the administration of the S-specific agent hydroxyurea].
The dependence of small intestinal lesions on the interval between repeated regular injections of hydroxyurea was studied. The doses of 1 g/kg and 0.2 g/kg were used. To activate the enterocyte proliferation the mice were pre-irradiated at 2 Gy. 3-4 hours after the last hydroxyurea injection the two distinct minimum points of epithelial lesions were observed at interinjection intervals of 9 and 16.5 hours. The result was dose-independent.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004848:Epithelium / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D005260:Female; D006918:Hydroxyurea / Q000633:toxicity*; D007399:Interphase / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D007421:Intestine, Small / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D051379:Mice; D013997:Time Factors
D006918:Hydroxyurea
Zavisimost' toksicheskoĭ gibeli énterotsitov tonkoĭ kishki mysheĭ ot intervala mezhdu vvedeniiami S-fazovo-spetsificheskogo agenta-oksimocheviny.