title: Progressive degeneration in the cochlear nucleus after chemical destruction of the cochlea.
abstract: In the guinea pig, the organ of Corti and the spiral ganglion cells were destroyed by administering gentamicin into the inner ear. The antero-ventral cochlear nucleus (AVCN) was studied with electron microscopy 15 and 30 days after treatment. There does not seem to be a specific type of degeneration induced by the drug. For nerve terminals, a progressive degeneration occurred: after 15 days, clear and swollen boutons appeared and after 30 days an electron-dense type of degeneration was observed. The cell bodies of the AVCN did not seem altered infirming a rapid, direct or indirect, neurotoxic effect of the drug.
mesh_terms: D000818:Animals; D003051:Cochlea / Q000187:drug effects*; D003056:Cochlear Nerve / Q000187:drug effects* / Q000648:ultrastructure; D005839:Gentamicins / Q000633:toxicity; D006168:Guinea Pigs; D008854:Microscopy, Electron; D009410:Nerve Degeneration / Q000187:drug effects*; D009411:Nerve Endings / Q000187:drug effects / Q000648:ultrastructure; D013997:Time Factors
chemical_list: D005839:Gentamicins