title: Acute toxicity of petroleum- and shale-derived distillate fuel, marine: light microscopic, hematologic, and serum chemistry studies.
abstract: Rats were gavaged with 60, 48, 38, 30, or 24 ml/kg of either petroleum (P) or shale (S)-derived distillate fuel, marine (DFM). Surviving rats were killed 14 days after dosing. There was a slight difference in toxicity of the two fuels but neither fuel was very toxic. The LD50/14 was 43 ml/kg for P-DFM and 50 ml/kg for S-DFM. Lesions in rats that died indicated hepatic and renal toxicity. In another study, rats were gavaged with 24 ml/kg of either P- or S-DFM and killed at 1, 2, or 3 days after dosing. Prominent clinicopathologic findings included loss of body weight, hematologic evidence of dehydration, transient leukopenia, and serum chemistry and histopathologic alterations indicative of mild hepatic and renal toxicity.
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D004798:Enzymes / Q000097:blood; D005648:Fuel Oils / Q000633:toxicity*; D007928:Lethal Dose 50; D008099:Liver / Q000648:ultrastructure; D008297:Male; D010578:Petroleum / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D004798:Enzymes; D005648:Fuel Oils; D010578:Petroleum