Strain differences in the radiation response of the rat heart.
Recent reports on radiation-induced heart disease in Wistar rats by ourselves and in Sprague-Dawley rats by Yeung and Hopewell indicate significant differences in response. Irradiation of Sprague-Dawley rats under exactly the same conditions as those for Wistar rats has shown that there is a strain dependence for latency and clinical course of the induced heart disease, but that its incidence changes similarly with dose in the two strains.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D006321:Heart / Q000528:radiation effects*; D006333:Heart Failure / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity