[Count and ultrastructure of large granule-containing lymphocytes in the blood of lymphogranulomatosis patients].
The blood-level and ultrastructure of large granular lymphocytes (LGL)--a subpopulation with natural killer activity--were studied in 120 cases of Hodgkin's disease and 50 healthy controls. A marked increase in the relative and total number of LGLs was observed in patients with complication--free stage I--II tumor. Electron microscopy identified changes in the size and ultrastructure of osmiophilic granules as well as a relatively higher level of parallel tubular arrays in LGL cytoplasm. Unfavorable clinical course involved a decrease in blood-LGL level. The results pointed to significant changes occurring in natural immunity in Hodgkin's disease.
D005260:Female; D006098:Granulocytes / Q000648:ultrastructure*; D006689:Hodgkin Disease / Q000097:blood*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008854:Microscopy, Electron
Kolichestvo i ul'trastruktura bol'shikh granulosoderzhashchikh limfotsitov v krovi bol'nykh limfogranulematozom.