Transhybridomas from fusion gene transgenic lymphocytes can be used to produce foreign protein of biological interest.
A method is described for achieving the efficient production of proteins of biological interest by the establishment of hybridomas from lymphocytes of transgenic animals carrying a fusion gene having promoter-regulatory sequences functional in lymphocytes fused to the coding sequences of the protein to be produced. While possible improvements in the method are discussed, it is anticipated that the method will ultimately be applicable to the production of any protein of interest.
D000818:Animals; D005260:Female; D013006:Growth Hormone / Q000235:genetics; D006183:H-2 Antigens / Q000235:genetics; D006824:Hybridization, Genetic; D006825:Hybridomas; D008214:Lymphocytes; D008297:Male; D051379:Mice; D008845:Microinjections
D006183:H-2 Antigens; D013006:Growth Hormone