Myocardial protection in coronary occlusion by retrograde cardioplegic perfusion via the coronary sinus in dogs. Preservation of high-energy phosphates and regional function.
The lack of adequate myocardial preservation because of maldistribution of cardioplegic solution in coronary artery disease remains a perplexing problem. We compared two methods of cardioplegic delivery in dogs: antegrade aortic root perfusion (Group I) and retrograde coronary sinus perfusion (Group II). Metabolic changes and regional function in the coronary occlusion model, in which the left anterior descending artery was occluded at its prediagonal portion, were studied. In the distribution of the occluded coronary artery, adenosine triphosphate and total adenine nucleotides at the end of 120 minutes of ischemia were preserved better in Group II (16.80 and 22.94 mumol/gm dry weight) than in Group I (11.06 and 16.19 mumol/gm dry weight, p less than 0.05). Lactate accumulation tended to be higher in Group I than in Group II (114.0 and 87.2 mumol/gm dry weight, respectively; not significant). Percent recovery of segmental shortening was also better in Group II than in Group I (100% and 22.3% at the same left atrial pressure, 4 mm Hg; p less than 0.01). In the region supplied by the intact coronary artery, there were no significant differences between the two groups with regard to metabolic changes and regional function. These observations suggest that retrograde cardioplegic perfusion via the coronary sinus is preferable for surgically treatment of severe coronary artery disease.
D000227:Adenine Nucleotides / Q000032:analysis; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D003250:Constriction; D003331:Coronary Vessels; D004285:Dogs; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D009206:Myocardium / Q000032:analysis; D010477:Perfusion; D011343:Procaine / Q000494:pharmacology / Q000627:therapeutic use*; D013012:Sorbitol / Q000494:pharmacology / Q000627:therapeutic use*
D000227:Adenine Nucleotides; D001224:Aspartic Acid; D011343:Procaine; D013012:Sorbitol; C006915:Cardioplegin