title: Influence of dietary tetramethylthiuram disulfide (a fungicide) on growth and incidence of tibial dyschondroplasia in single comb White Leghorn chicks.
abstract: The effect of dietary tetramethylthiuram disulfide (TMTD) (0, 30, or 60 mg/kg diet) on the performance and incidence and severity of tibial dyschondroplasia (TD) in Single Comb White Leghorn (SCWL) chicks was studied in a 6-week experiment. Body weights (3 weeks of age) and bone ash (4 and 6 weeks of age) of chicks fed either 30 or 60 mg TMTD/kg diet were significantly lower compared to controls. Dietary TMTD, however, significantly increased the incidence and severity of TD in layer chicks with the highest incidence (69%) occurring in 6-week old-birds. This study showed that SCWL chicks were susceptible to TMTD-induced TD as early as 2-weeks of age and that the condition persisted throughout the growing phase.
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects; D002645:Chickens / Q000254:growth & development*; D005659:Fungicides, Industrial / Q000633:toxicity*; D008297:Male; D010009:Osteochondrodysplasias / Q000139:chemically induced / Q000662:veterinary*; D011201:Poultry Diseases / Q000139:chemically induced*; D013859:Thiocarbamates / Q000494:pharmacology*; D013893:Thiram / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D005659:Fungicides, Industrial; D013859:Thiocarbamates; D013893:Thiram