Comparative pharmacokinetics of azlocillin and piperacillin in normal adults.
The single-dose pharmacokinetics of azlocillin and piperacillin were compared by using a randomized, crossover design. The concentrations of azlocillin in serum were consistently higher than those of piperacillin throughout an 8-h study. The area under the time-concentration curve of azlocillin was significantly greater than that of piperacillin, and the total body clearance of azlocillin was significantly lower than that of piperacillin.
D000328:Adult; D001390:Azlocillin / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D010878:Piperacillin / Q000097:blood / Q000378:metabolism*
D001390:Azlocillin; D010878:Piperacillin