[Follow-up of Wegener's granulomatosis with kidney involvement].
It is reported on long-term courses in five patients with Wegener's granulomatosis. Under a treatment with glucocorticoids and immunosuppressive agents lasting several years in all cases a remission developed. In these cases the participation of the kidneys is fateful, whereby from the very beginning a large proportion of sclerosing glomeruli lead to a greater healing of the defect. While the troubles of the patients under the apparently at present unspecific effect of high doses of prednisolone disappear within a few weeks, the onset of the remission lasts at least nine months. It is tried to form criteria which indicate a remission. The treatment with a low maintenance dose for at least one year after the remission seems to be justified in consideration of the frequency of recidivations.
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D005260:Female; D005500:Follow-Up Studies; D005920:Glomerular Mesangium / Q000473:pathology; D005921:Glomerulonephritis / Q000473:pathology*; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology; D014890:Granulomatosis with Polyangiitis / Q000473:pathology*; D006801:Humans; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008875:Middle Aged
Verlaufsbeobachtung bei Wegenerscher Granulomatose mit Nierenbeteiligung.