Soluble fibrinogen derivatives generated by thrombin: affinity for elastin.
When human citrated plasma is dialysed against a phosphate buffer containing Ca++, citrate anions are removed, thrombin is generated and soluble fibrinogen derivatives (fibrin monomers and/or soluble fibrin polymers) are formed. These derivatives are able to combine with human or bovine elastin to form a very stable addition product or adduct. The formation of the adduct is dependent on time, Ca++ and thrombin concentrations.
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology; D002118:Calcium / Q000378:metabolism; D002417:Cattle; D002951:Citrates; D019343:Citric Acid; D003956:Dialysis; D004549:Elastin / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D012995:Solubility; D013917:Thrombin / Q000378:metabolism*; D013927:Thrombosis / Q000209:etiology
D002951:Citrates; D019343:Citric Acid; D005340:Fibrinogen; D004549:Elastin; D013917:Thrombin; D002118:Calcium