Focal cerebral vasculitis associated with circulating immune complexes and brain irradiation.
In this report we describe a patient with a benign glioma treated with surgery and radiation. After a period of stability he developed subacute bacterial endocarditis, and deteriorated neurologically. Computed tomographic scans did not show recurrent tumor. An angiogram showed vasculitis restricted to the previously irradiated area. Secondary to subacute bacterial endocarditis was the presence of high levels of circulating immune complexes. His neurological status was unchanged after antibiotics, but improved after treatment with dexamethasone. We interpret the clinical course as an immune-complex-mediated vasculitis superimposed on a subclinical radiation vasculitis. This case supports the hypothesis that immune mechanisms may be involved in delayed radiation injury to the nervous system.
D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis*; D001254:Astrocytoma / Q000532:radiotherapy; D001812:Blood-Brain Barrier / Q000528:radiation effects; D001921:Brain / Q000528:radiation effects; D001932:Brain Neoplasms / Q000532:radiotherapy; D002561:Cerebrovascular Disorders / Q000209:etiology*; D004698:Endocarditis, Subacute Bacterial / Q000150:complications; D006801:Humans; D008297:Male; D011878:Radiotherapy / Q000009:adverse effects*; D013702:Temporal Lobe; D014657:Vasculitis / Q000209:etiology*
D000936:Antigen-Antibody Complex