title: Genetic polymorphism of coagulation factor XIII B subunit in the Japanese population: description of three new rare alleles.
abstract: Polyacrylamide gel isoelectric focusing (PAGIEF) of neuraminidase-treated EDTA plasma samples followed by electroblotting with enzyme immunoassay was performed to further investigate coagulation factor XIII B subunit (FXIII B) polymorphism. In 435 Japanese subjects PAGIEF patterns of FXIII B were classified into five common and three rare allotypes. This suggested that the FXIII B*2 allele existed in the Japanese population in the same manner as in Caucasians. Three new rare allotypes were considered to be controlled by three rare alleles which were designated FXIII B*13, FXIII B*14, and FXIII B*15, respectively. The gene frequencies calculated from 435 Japanese subjects were FXIII B*1 = 0.2977, FXIII B*2 = 0.0184, FXIII B*3 = 0.6805, FXIII B*13 = 0.0011, FXIII B*14 = 0.0011, and FXIII B*15 = 0.0011, respectively.
mesh_terms: D000483:Alleles; D004591:Electrophoresis, Polyacrylamide Gel; D005176:Factor XIII / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D007564:Japan; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D005176:Factor XIII