Genetic and dietary influences on the levels of diet-induced thermogenesis and energy balance in adult mice.
Genetic and dietary influences on energy balance and diet-induced thermogenesis were investigated in 5 strains of adult mice fed either a stock diet or a varied and palatable cafeteria diet for 4 weeks. Compared to their stock-fed controls, the total metabolisable energy intake of mice fed a cafeteria diet increased by 60, 45, 28, 50 and 35% in the ob/+ or +/+, C57BL/6, DBA/2, BALB/C and CFLP strains, respectively, while energy expenditure, over the entire period, was increased by 53, 21, 24, 53 and 34%, respectively. The results show the presence of diet-induced thermogenesis in most strains studied, and also indicate that variations in food intake were more strongly determined by diet, whereas variations in energy efficiencies were more strongly influenced by genetics.
D000818:Animals; D001823:Body Composition; D001833:Body Temperature Regulation; D001835:Body Weight; D004032:Diet; D004435:Eating; D004734:Energy Metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013045:Species Specificity