[Relation between the increase in the anti-oxidative activity of lipids and the activity of the blood coagulation system].
Relationship between alterations in the state of lipid antioxidative activity (AOA) and the patterns of blood coagulation system (content of fibrinogen, the rate of fibrinolytic activity and the period of blood coagulation) were studied after administration of a synthetic antioxidant ionol into animals and after partial hepatectomy and with Ehrlich ascites hepatoma. An increase in the lipid AOA in animal tissues correlated with a decrease in fibrinolytic activity and in the blood coagulation period. Concentration of fibrinogen was decreased similarly after hepatectomy and after the antioxidant administration. In the course of development of Ehrlich ascites hepatoma concentration of fibrinogen was increased. Interrelationship found between the alterations in lipid AOA and the patterns of blood coagulation as well as distinct impairment of these relations during malignant growth confirmed high importance of alterations in the rate of oxidative reactions for the processes of blood coagulation.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D002286:Carcinoma, Ehrlich Tumor / Q000097:blood; D006498:Hepatectomy; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008563:Membrane Lipids / Q000097:blood / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D010084:Oxidation-Reduction; D013154:Spleen / Q000378:metabolism
D000975:Antioxidants; D008563:Membrane Lipids
Vzaimosviaz' mezhdu povysheniem antiokislitel'noĭ aktivnosti lipidov i aktivnost'iu svertyvaiushcheĭ sistemy krovi.