The effect of the thromboxane synthetase inhibitor Dazmegrel (UK-38,485) on wound healing, dermal ink perfusion and skin blood flow measurements in deep partial thickness burns.
A guinea-pig model was used to evaluate the effect of Dazmegrel (UK-38,485), a new highly selective inhibitor of thromboxane synthetase, on burn wound healing. Dazmegrel had a beneficial effect on wound healing when given systemically at a dosage of 3.4 mg kg-1 day-1 but higher doses had no effect. There was no change in dermal perfusion measured by India ink injection or by 133Xe injection in any of the groups receiving parenteral Dazmegrel. Neither was the number of hair follicles in the healing burn wound significantly different between the treated and control animals. When Dazmegrel was applied topically, it inhibited wound healing. These findings are consistent with previous reports from different laboratories that prostaglandin inhibitors impair healing of the burn wound when applied topically but improve wound healing when given parenterally. The present study further suggested that the improvement in wound healing in this model was not mediated by improved dermal perfusion.
D000287:Administration, Topical; D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000503:physiopathology; D002244:Carbon; D004396:Coloring Agents; D005260:Female; D006168:Guinea Pigs; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D007273:Injections, Intramuscular; D010477:Perfusion; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply*; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*; D014945:Wound Healing / Q000187:drug effects*; D014980:Xenon Radioisotopes
D004396:Coloring Agents; D007093:Imidazoles; D014980:Xenon Radioisotopes; C028433:chinese ink; C039242:dazmegrel; D002244:Carbon; D013930:Thromboxane-A Synthase