Role of hippocampal Met-enkephalin in the genotype-dependent regulation of exploratory behavior in mice.
Intrahippocampal microinjections with anti-Met-enkephalin antiserum enhanced novelty-induced vertically oriented exploratory acts and horizontal locomotor activity in inbred mouse strain DBA/2 and reduced these behaviors in C57BL/6 so that strain differences originally present between the normal serum controls were eliminated after antiserum treatment. These opposite effects suggest that hippocampal Met-enkephalin participates in the genotype-dependent control of mouse exploration.
D000818:Animals; D000936:Antigen-Antibody Complex; D004744:Enkephalin, Methionine / Q000502:physiology*; D005106:Exploratory Behavior; D006624:Hippocampus / Q000502:physiology*; D007106:Immune Sera; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D008811:Mice, Inbred DBA / Q000235:genetics*; D008845:Microinjections; D013045:Species Specificity
D000936:Antigen-Antibody Complex; D007106:Immune Sera; D004744:Enkephalin, Methionine