Regional distribution of a novel peptide (P7 of 1B236) immunoreactivity in the human central nervous system.
The regional distribution of a novel peptide (P7 of 1B236) in the human central nervous system (CNS) was examined. P7-like-immunoreactivity (p7-LI) was shown to be distributed throughout the CNS, with a chromatographic pattern closely similar to that previously described in rat. In the brain the concentrations of P7-LI were higher in the globus pallidus and substantia nigra than in any other regions. Considerable amounts of P7-L1 were also found in the cerebellum. In the spinal cord the concentration of P7-L1 was slightly higher in the ventral than in the dorsal cord, though no difference in concentration was found between cervical, thoracic, lumbar and sacral regions. The distribution pattern of this novel peptide reveals its predominance in sub-cortical motor areas. Studies of its pharmacological effects and possible role in movement disorders are awaited with interest.
D000328:Adult; D000368:Aged; D002490:Central Nervous System / Q000032:analysis*; D002531:Cerebellum / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005917:Globus Pallidus / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis*; D010446:Peptide Fragments / Q000032:analysis*; D011863:Radioimmunoassay; D013116:Spinal Cord / Q000032:analysis; D013378:Substantia Nigra / Q000032:analysis
C045772:1B236 polypeptide; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments