Pathogenesis of corneal lesions in measles.
The mechanism of pathogenesis underlying the development of corneal lesions in measles was investigated in 125 children suffering from measles and 66 age- and sex-matched healthy controls. Forty age-matched children with bronchopneumonia were investigated on similar lines to delineate the role played by vitamin A and measles individually in the development of corneal lesions. The results indicate that the pathogenesis of corneal lesions in measles is indeed multifactorial. Vitamin A deficiency alone or measles keratitis per se may not explain the mechanism completely. The immunosuppression induced by the local proliferation of the measles virus in the eye might trigger the invasion of pathogenic microbes which damage the cornea. The structural integrity of the cornea is already compromised by vitamin A deficiency and lesions of measles keratitis.
D001996:Bronchopneumonia / Q000378:metabolism; D002648:Child; D003315:Cornea / Q000473:pathology; D003316:Corneal Diseases / Q000209:etiology* / Q000378:metabolism; D005123:Eye / Q000382:microbiology; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007634:Keratitis / Q000378:metabolism / Q000473:pathology; D008457:Measles / Q000150:complications* / Q000378:metabolism; D009113:Muramidase / Q000032:analysis; D013666:Tears / Q000032:analysis*; D014801:Vitamin A / Q000097:blood*
D007071:Immunoglobulin A, Secretory; D014801:Vitamin A; D009113:Muramidase