Bronchial blood flow affects recovery from constriction in dog lung periphery.
We investigated the effect of eliminating the bronchial circulation on recovery time from intravenous histamine challenge in canine lung periphery. Results from animals with intact bronchial circulations were compared with a second group in which the left lower lobe was isolated in situ. The pulmonary artery to this lobe was perfused and a bronchoscope was wedged in a small airway, which provided an index of resistance to airflow through the collateral system. The lobe was challenged with intravenous histamine, and the time constant of recovery (tau) from bronchoconstriction was measured. With or without pulmonary blood flow, elimination of the bronchial circulation increased tau 44.4 and 48.5%, respectively. This increase was similar to that found by stopping pulmonary blood flow alone (56.5%). Histamine challenges were also performed in sympathectomized or vagotomized animals with intact bronchial circulations. Neither of these conditions increased tau. We conclude that blood flow through the bronchial circulation affects the recovery time from intravenous histamine challenge in the lung periphery to a degree similar to that of the pulmonary circulation.
D000818:Animals; D001980:Bronchi / Q000098:blood supply*; D001986:Bronchial Spasm / Q000503:physiopathology*; D004285:Dogs; D008297:Male; D010827:Physiology / Q000295:instrumentation; D011652:Pulmonary Circulation; D012039:Regional Blood Flow; D012110:Reserpine / Q000494:pharmacology; D014628:Vagotomy
D012110:Reserpine