title: Dystonia-Parkinson syndrome: differential effects of levodopa and dopamine agonists.
abstract: Eleven patients who presented with predystonic syndrome later developed pure dystonic syndromes and later developed parkinsonism. This suggests that dystonic syndromes can be the precursor to a mixed syndrome including both dystonia and parkinsonism. While the parkinsonian features in such patients respond to either levodopa or direct-acting agonists, levodopa often exacerbates the underlying dystonia. Direct acting agonists appear to be less liable to do this.
mesh_terms: D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use; D002230:Carbidopa / Q000627:therapeutic use*; D004421:Dystonia / Q000150:complications* / Q000188:drug therapy; D004873:Ergolines / Q000627:therapeutic use; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008538:Meige Syndrome / Q000150:complications; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D010479:Pergolide; D014103:Torticollis / Q000150:complications
chemical_list: D004873:Ergolines; D010479:Pergolide; D001971:Bromocriptine; D007980:Levodopa; D002230:Carbidopa