title: [Distribution of 4-14C-mofebutazone in the rat].
abstract: To further elucidate the distribution and differentiation of mofebutazone in comparison to phenylbutazone, 6 rats received 200 mg/kg 4-14C-mofebutazone corresponding to approx. 27 microCi/animal. 2 animals were sacrificed each time after 45 min, 6 h and 24 h. The 4-14C-plasma level was determined at the corresponding test periods and the radioactivity eliminated within 24 h in the urine was also determined. In addition autoradiograms of the whole animal were prepared for each animal. According to this study 4-14C-mofebutazone is distributed mainly in the metabolisation and elimination organs, a moderate activity was to be found under the skin and muscle tissue, but none, however, in the central nervous system and the bone marrow. Nearly 81% of the substance was eliminated after 24 h and with exception the colon the corresponding autoradiograms were practically free of activity. Because of the short half-life time and the rapid elimination mofebutazone does not lead to any accumulation.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000097:blood*; D008297:Male; D008657:Metabolic Clearance Rate; D010653:Phenylbutazone / Q000031:analogs & derivatives* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D000893:Anti-Inflammatory Agents; D010653:Phenylbutazone; C002374:mofebutazone
vernacular_title: Zur Verteilung von 4-14C-Mofebutazon bei der Ratte.