[Bioequivalence of piracetam following acute administration of an oral solution or two tablet formulations in volunteers].
In an open, non-randomized 3-way cross-over study, the bioavailability of 2-oxo-pyrrolidine-1-acetamide (piracetam, Encetrop) from two solid oral formulations and one liquid formulation was tested in 8 healthy male volunteers. The area under the concentration time curve, which is defined to be a measurement for bioequivalence among the three tested galenic formulations correlated very well with the area under the effect intensity-time curve, which was estimated in the same volunteers using electro-physiological methods. The different methods of estimation of bioequivalence show similarity between both solid galenic formulations, while the liquid form exhibits superiority in respect to the oral solid formulations.
D000328:Adult; D006801:Humans; D008297:Male; D008954:Models, Biological; D010889:Piracetam / Q000008:administration & dosage / Q000378:metabolism*; D011760:Pyrrolidinones / Q000378:metabolism*; D012996:Solutions; D013607:Tablets; D013810:Therapeutic Equivalency
D011760:Pyrrolidinones; D012996:Solutions; D013607:Tablets; D010889:Piracetam
Bioäquivalenz von Piracetam nach Akutdosierung einer oralen Lösung und zweier Tablettenpräparationen an Probanden.