Effect of low-dose dopamine on the pharmacokinetics of tobramycin in dogs.
Low-dose dopamine or a placebo was given to six healthy mongrel dogs, each receiving tobramycin at 2.0 mg/kg on consecutive days in a randomized crossover fashion. Dopamine increased the total and renal clearances and elimination rate constant of tobramycin by 12.5, 20, and 25.9%, respectively, suggesting that low-dose dopamine increases the clearance of tobramycin in dogs primarily through renal mechanisms.
D000818:Animals; D004285:Dogs; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D013268:Stimulation, Chemical; D014031:Tobramycin / Q000378:metabolism*
D004298:Dopamine; D014031:Tobramycin