[Effect ot tuftsin on cerebral monoamine oxidase and acetylcholinesterase activity].
The administration of a tetrapeptide tuftsin at a dose of 300 mkg/kg body weight for 30, 75 min or 3 days leads to the changes in specific activity of monoamine oxidase, forms A and B, and acetylcholinesterase in synaptosomal and cellular mitochondrial subfractions from the rabbit sensorimotor cortex and nucleus caudatus. The reciprocity of neuro-transmitter systems and specific peptide effects on the brain structures have been demonstrated. The results suggest that tuftsin has an activating effect on dopamine metabolism.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002421:Caudate Nucleus / Q000187:drug effects / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism*; D011817:Rabbits; D013003:Somatosensory Cortex / Q000187:drug effects / Q000201:enzymology; D014405:Tuftsin / Q000494:pharmacology*
D008995:Monoamine Oxidase; D000110:Acetylcholinesterase; D014405:Tuftsin
Deĭstvie taftsina na aktivnost' monoaminoksidaz i atsetilkholinésterazy mozga.