Effects of a new anti-allergic agent: the magnesium salt of N-acetyl-aspartyl-glutamic acid on experimental allergic inflammation of the rabbit eye.
We evaluated the efficacy of N-Acetyl-Aspartyl-Glutamic acid (magnesium salt) (NAAGA) eye-drops in preventing the conjunctival and uveal allergic inflammation induced by reverse passive Arthus reaction in the rabbit. The permeability of the blood-conjunctival and blood-aqueous barriers was investigated by the leakage of 125I-labelled rabbit serum albumin injected intravenously prior to the challenge with the antigen. Permeability of both barriers was markedly increased 2 hours after the triggering of the allergic reaction; marked edema of the conjunctiva was also observed. Pretreatment with 1, 3, 6% (w/w) NAAGA eye-drops prevented the conjunctival inflammatory changes in a dose related manner and to a lesser degree, the breakdown of the blood-aqueous barrier. The distribution of topically applied 14C-NAAGA in the rabbit eyes was also investigated.
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D002199:Capillary Permeability; D003231:Conjunctivitis / Q000188:drug therapy* / Q000378:metabolism; D004151:Dipeptides / Q000627:therapeutic use*; D005123:Eye / Q000378:metabolism; D006967:Hypersensitivity / Q000188:drug therapy* / Q000378:metabolism; D007700:Kinetics; D009994:Osmolar Concentration; D011817:Rabbits; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors; D014605:Uveitis / Q000188:drug therapy / Q000378:metabolism
D004151:Dipeptides; D012709:Serum Albumin; C027172:isospaglumic acid