Acute effects of ethanol on protein synthesis in the rat.
The effect of ethanol, administered acutely (75 mmol kg-1), on protein synthesis in the whole body and in the tissues of the rat was investigated. Ethanol decreased whole-body protein synthesis by 41% and also that in individual tissues (liver: 60%; muscle: 75%; heart: 45%; kidney: 59%; spleen: 73%; plasma protein: 44%; lung: 64%). These data indicate a generalised effect upon protein synthesis and are discussed in relation to the possible mode of action of ethanol.
D000818:Animals; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D007668:Kidney / Q000187:drug effects; D007700:Kinetics; D008099:Liver / Q000187:drug effects; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D014443:Tyrosine / Q000378:metabolism
D000431:Ethanol; D014443:Tyrosine