Proliferation of Dunning R-3327 rat prostatic adenocarcinoma and of its sublines (CUA and CUB).
Proliferating cells in tumors of the androgen-dependent R-3327 and its partially dependent and autonomous sublines, CUA and CUB, were examined. Two types of cells, myoepithelial cells and large stromal cells, in the R-3327 have a high proliferating ability, as estimated by thymidine uptake. These cells were also observed in the normal dorsolateral prostate of rats, the lobes from which R-3327 originated. CUA is a squamous carcinoma, which proliferates at the border of the epithelial layer and large stromal cells. The tumor cells of CUB appear as clusters of large stromal cells which have a strong potential for dividing. Therefore, R-3327 contains two types of dividing cells, and their uncoordinated proliferation may be responsible for causing the different features seen in the sublines.
D000230:Adenocarcinoma / Q000473:pathology / Q000503:physiopathology* / Q000648:ultrastructure; D000818:Animals; D002455:Cell Division; D002460:Cell Line; D008297:Male; D008854:Microscopy, Electron; D011467:Prostate / Q000166:cytology / Q000648:ultrastructure; D011471:Prostatic Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000648:ultrastructure; D051381:Rats