Desferrioxamine administered intravenously by infusion causes a reduction in the electroretinogram in rabbits anaesthetized with urethane.
In rabbits anaesthetized with urethane, intravenous infusion of the iron-chelating drug desferrioxamine causes a reduction in the amplitude of the electroretinogram. This is most pronounced for weak light intensities, but the change is more complex than a mere reduction in sensitivity. In experiments lasting up to 3 days the effect is reversible and is not accompanied by electron-microscopical histological changes.
D000758:Anesthesia; D000818:Animals; D003676:Deferoxamine / Q000633:toxicity*; D004596:Electroretinography; D007263:Infusions, Parenteral; D008854:Microscopy, Electron; D011817:Rabbits; D051381:Rats; D012160:Retina / Q000187:drug effects* / Q000648:ultrastructure; D014520:Urethane / Q000494:pharmacology
D014520:Urethane; D003676:Deferoxamine