title: Timentin--clinical and pharmacokinetic evaluation in otorhinolaryngology.
abstract: The efficacy and tolerance of Timentin was studied in 41 patients with various infections of the ears, nose and throat. The pharmacokinetics of Timentin were determined in pus, mucosa and polyps of the nose and paranasal sinuses, the tonsils and submandibular gland as well as in the interstitial fluid collected in Redon vacuum drainage. Experimental pharmacokinetic studies in the guinea pig were performed in the inner ear and eye fluids and in serum. Ticarcillin and clavulanic acid concentrations were determined by a microbiological micromethod. The clinical studies demonstrated that Timentin was very effective and well tolerated. The clinical and experimental pharmacokinetic studies provide a good explanation of this high degree of effectiveness.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy* / Q000378:metabolism; D002969:Clavulanic Acids / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D004338:Drug Combinations / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007700:Kinetics; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010038:Otorhinolaryngologic Diseases / Q000188:drug therapy* / Q000378:metabolism; D010406:Penicillins / Q000627:therapeutic use*; D013982:Ticarcillin / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D002969:Clavulanic Acids; D004338:Drug Combinations; D010406:Penicillins; C043215:ticarcillin-clavulanic acid; D013982:Ticarcillin