title: Immunochemical aspects of cerebrospinal fluid immunoglobulins in patients with subacute sclerosing panencephalitis.
abstract: Unconcentrated cerebrospinal fluid (CSF) samples from 50 patients with subacute sclerosing panencephalitis (SSPE) were investigated by rocket immunoelectrophoresis (RIE) against anti-human IgG sera. Two patterns of immune precipitates were observed: precipitates with exclusively cathodal and precipitates with bipolar extension. Hemagglutination-inhibition tests against measles virus antigen were performed after absorption of the CSF samples with Protein A-containing Staphylococcus aureus and treatment with 2-mercaptoethanol. The results point to different pathological significances of the precipitation line anomalies revealed by RIE, that might be relevant for some of the patients investigated.
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007122:Immunoelectrophoresis / Q000379:methods; D007136:Immunoglobulins / Q000032:analysis*; D008459:Measles virus / Q000276:immunology; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology; D009423:Nervous System Neoplasms / Q000134:cerebrospinal fluid / Q000276:immunology; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid / Q000276:immunology; D013344:Subacute Sclerosing Panencephalitis / Q000134:cerebrospinal fluid* / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007136:Immunoglobulins