title: Ectodermal defects and chronic mucocutaneous candidiasis in idiopathic hypoparathyroidism.
abstract: Idiopathic hypoparathyroidism is a rare disorder produced by parathyroid hormone deficiency of unknown cause. It is often associated with other endocrine abnormalities. Patients with idiopathic hypoparathyroidism frequently develop ectodermal disease, including dry, rough skin: coarse, brittle hair; and lusterless, distally split nails. All of these complaints are relatively common in a dermatologic practice. Chronic mucocutaneous candidiasis is also a manifestation of idiopathic hypoparathyroidism. A patient is presented with a prominent ectodermal dysplasia and a chronic mucocutaneous candidiasis that were due to the underlying idiopathic hypoparathyroidism. A brief review of idiopathic hypoparathyroidism is included, as well as the implications of this diagnosis in terms of differential diagnosis, associated endocrine disorders, and therapy.
mesh_terms: D002177:Candidiasis / Q000175:diagnosis*; D002178:Candidiasis, Chronic Mucocutaneous / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D004476:Ectodermal Dysplasia / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000150:complications*; D008875:Middle Aged; D012867:Skin / Q000473:pathology