Effect of clofibrate and hydrocortisone on intestinal trichinellosis in mice.
These investigations show the immunosuppressive effects of Clofibrate (CPIB) and hydrocortisone on the intestinal cycle of Trichinella nelsoni. They demonstrate an effect of CPIB similar to that of hydrocortisone in the establishment of the muscular and intestinal phase of this parasite. A higher retention rate of intestinal adult worms was observed in hydrocortisone-treated mice. These facts are consistent with the idea that CPIB can act on diverse immune cells, involving both thymus-dependent and thymus-independent antigens.
D000818:Animals; D002994:Clofibrate / Q000494:pharmacology*; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D007422:Intestines / Q000469:parasitology*; D007814:Larva; D051379:Mice; D014234:Trichinella / Q000187:drug effects*; D014235:Trichinellosis / Q000276:immunology
D002994:Clofibrate; D006854:Hydrocortisone