title: [DNA synthesis inhibition test of INAH by cultured human fibroblasts].
abstract: The most commonly used screening test of carcinogens is the Ames test. But this system occasionally shows false positive and false negative. Painter's method is one which has been developed to minimize false results. Now we test by Painter's method isonicotinic acid hydrazide, which shows negative in the Ames test but positive in an animal test. INAH showed positive by Painter's method. More chemicals are now under study for their carcinogenicity by Painter's method.
mesh_terms: D004247:DNA / Q000096:biosynthesis*; D003864:Depression, Chemical; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D009152:Mutagenicity Tests / Q000379:methods*
chemical_list: D004247:DNA; D007538:Isoniazid