Thyroid hormone administration in irradiated patients.
In a recall clinic for patients at risk for thyroid carcinoma due to a history of radiation in infancy or childhood, a group of patients were randomly offered prospective suppressive L-thyroxine therapy and matched to a radiated nontreated group. With an average of more than two years' follow-up, the thyroid hormone-treated radiated group developed fewer nodules and abnormalities to palpation and also had a statistically significant lessening of minimal palpable abnormalities compared to the nonthyroxine-treated radiated group.
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects; D011897:Random Allocation; D012306:Risk; D013964:Thyroid Neoplasms / Q000209:etiology / Q000517:prevention & control*; D013974:Thyroxine / Q000627:therapeutic use*; D013997:Time Factors
D013974:Thyroxine