[Subjective findings in emotionally stable and labile subjects following oral application of flupenthixol in small doses].
The mood-changing effects of flupentixol (Fluanxol 0.5 mg) were evaluated in a double-blind study with 107 healthy male subjects. Experimental factors were dosage (0, 1 and 2 mg flupentixol/day), time of measurement (before, during, and after 4 days of treatment), and the trait variable "neuroticism" (high vs. low score on a questionnaire scale). Drug effects were measured by means of rating scales and symptom checklists. Statistical analyses revealed that state anxiety and bodily symptoms associated with depressive states were diminished by flupentixol. Moreover, emotionally labile subjects reported an impairment of vigilance under drug treatment. Placebo effects proved to be more substantiated in the group of emotionally stabile subjects than in the group of emotionally labile subjects.
D000328:Adult; D001288:Attention / Q000187:drug effects; D004311:Double-Blind Method; D004644:Emotions / Q000187:drug effects*; D005475:Flupenthixol / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009497:Neurotic Disorders / Q000523:psychology; D010551:Personality; D013892:Thioxanthenes / Q000494:pharmacology*
D013892:Thioxanthenes; D005475:Flupenthixol
Subjektives Befinden emotional labiler und stabiler Probanden nach oraler Applikation von Flupentixol in niedrigen Dosierungen.