Effect of neurotensin in the dumping syndrome.
The possibility that the gut peptide, neurotensin, may contribute to the dumping syndrome was investigated in 17 patients with a long history of dumping after a Billroth II gastrectomy for duodenal ulcer. After a test meal plasma levels of neurotensin were higher than in normal subjects, but no correlation to the severity of symptoms was found. In eight of the patients with meal-provoked dumping symptoms, intravenous infusion of neurotensin in relevant doses produced neither symptoms nor changes in blood glucose, blood pressure, or pulse rate. The apparent plasma half-life of neurotensin (t1/2 = 2.3 min) did not differ from that previously found in normal subjects. The results indicate that it is unlikely that neurotensin alone has a pathogenetic role in the dumping syndrome in gastrectomized patients.
D000368:Aged; D002850:Chromatography, Gel; D004377:Dumping Syndrome / Q000097:blood* / Q000209:etiology; D004381:Duodenal Ulcer / Q000601:surgery; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009496:Neurotensin / Q000008:administration & dosage / Q000097:blood*; D011183:Postoperative Complications; D011863:Radioimmunoassay
D009496:Neurotensin