Influenza A viruses with noncleaved hemagglutinin are not internalized after adsorption. Brief report.
Influenza A viruses with noncleaved hemagglutinin (HA) are not internalized after adsorption, since they can be removed and/or inactivated by washing the infected cells at pH 2.5, in contrast to virus with cleaved HA. If uptake of influenza viruses into endosomes is a presupposition for fusion between viral and cellular membranes, this uptake does not occur with virus possessing noncleaved HA.
D000327:Adsorption; D000818:Animals; D002459:Cell Fusion; D002642:Chick Embryo; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral / Q000276:immunology*; D006863:Hydrogen-Ion Concentration; D009980:Influenza A virus / Q000502:physiology; D007425:Intracellular Membranes / Q000502:physiology; D008247:Lysosomes / Q000502:physiology
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral