title: A new vitamin E analogue more active than alpha-tocopherol in the rat curative myopathy bioassay.
abstract: Vitamin E owes its biological effects to its antioxidant activity. Kinetic and mechanistic studies on phenolic antioxidants in vitro have led us to design and synthesize all-rac-2,4,6,7-tetramethyl-2-(4',8',12'-trimethyltridecyl) -5-hydroxy-3,4-dihydrobenzofuran, 3. In the rat curative myopathy bioassay the acetate of this compound has 1.5-1.9 times the bioactivity of all-rac-alpha-tocopherol acetate. This represents the first time that a rationally designed synthetic 'vitamin' has been found to have more activity in vivo than the corresponding natural vitamin.
mesh_terms: D000818:Animals; D004032:Diet; D007700:Kinetics; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D011770:Pyruvate Kinase / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000201:enzymology
chemical_list: C049881:2,4,6,7-tetramethyl-2-(4',8',12'-trimethyltridecyl)-5-hydroxy-3,4-dihydrobenzofuran; D014810:Vitamin E; D011770:Pyruvate Kinase; D024505:Tocopherols