title: Laryngeal manifestations of Wegener's granulomatosis: case reports and review of the literature.
abstract: We report two patients with laryngeal manifestations of Wegener's granulomatosis to demonstrate the marked variability of presentation in this disease. The reported literature is reviewed and shows a similar spectrum with early and late onset of laryngeal granulomata, subglottic in location. Of all the patients with Wegener's granulomatosis reviewed, 8.5% will eventually develop a subglottic lesion. Therapy depends upon response to steroids, cytotoxic drugs, and radiation therapy. Usually surgical therapy will be necessary.
mesh_terms: D000402:Airway Obstruction / Q000209:etiology / Q000628:therapy; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007249:Inflammation; D007818:Laryngeal Diseases / Q000150:complications / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D014140:Tracheotomy
chemical_list: D003520:Cyclophosphamide