[Metastable and steady-state solubility of the salt forms of semisynthetic penicillins at 4 degrees C].
Steady-state and metastable solubility of penicillin salts in water, aqueous organic solutions and the same systems with addition of an inorganic electrolyte at a temperature of 4.0 +/- 1.0 degree C was studied. The leveling effect of the temperature decrease on the difference in solubility of modifications I and II of sodium salts of methicillin, oxacillin and dicloxacillin in isopropanol, acetone and respective aqueous organic solutions with insignificant water content was observed. An increase in the salting-out effect of sodium chloride on solubility of sodium salts of carbenicillin, methicillin, oxacillin and dicloxacillin at lowered temperatures was revealed.
D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D010406:Penicillins / Q000494:pharmacology*; D012995:Solubility; D012996:Solutions; D013696:Temperature
D010406:Penicillins; D012996:Solutions
Metastabil'naia i ravnovesnaia rastvorimost' solevykh form polusinteticheskikh penitsillinov pri 4 gradusa C.