title: Effect of glucose added to intraocular irrigating solutions on the rabbit electroretinogram in vitro.
abstract: The most adequate concentration of glucose in intraocular irrigating solution for the retina was studied electrophysiologically in the pigmented rabbit in vitro. Comparison of b-wave amplitudes demonstrated that glucose at a concentration of 20 mM/l yielded the highest values. A 40 mM/l glucose solution also increased the b-waves but to a lesser extent than did a solution of 20 mM/l. This result might be due to the detrimental effects of osmolarity. However, under hypoxic conditions the amplitudes of the b-wave obtained with 40 mM/l glucose solution was greater than those with 20 mM/l. It thus appears that slight hyperglycemic concentrations might have favorable effects on the ischemic retina.
mesh_terms: D000818:Animals; D004596:Electroretinography; D005123:Eye; D005632:Fructose / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology*; D066298:In Vitro Techniques; D009994:Osmolar Concentration; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000502:physiology; D012996:Solutions; D007507:Therapeutic Irrigation; D013997:Time Factors
chemical_list: D012996:Solutions; D005632:Fructose; D005947:Glucose