Isolation of evodiamine, a powerful cardiotonic principle, from Evodia rutaecarpa Bentham (Rutaceae).
The crude acetone extract of the fruits of Evodia rutaecarpa Bentham (Rutaceae) exhibited a positive inotropic effect on the guinea pig isolated left atria. The extract was subject to bioassay-directed fractionation to yield the powerful cardiotonic agent evodiamine.
D000818:Animals; D002316:Cardiotonic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007564:Japan; D009200:Myocardial Contraction / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis*; D011799:Quinazolines / Q000302:isolation & purification* / Q000494:pharmacology
D002316:Cardiotonic Agents; D010936:Plant Extracts; D011799:Quinazolines; C049639:evodiamine