Luteal phase serum progesterone levels after follicle aspiration with and without clomiphene citrate treatment.
Peripheral serum progesterone (P) levels were studied on random days after the spontaneous luteinizing hormone (LH) surge in women who underwent follicle aspiration. Comparisons were made with ovulatory women treated with clomiphene citrate (CC) undergoing follicle aspiration and women undergoing midcycle general anesthesia and laparoscopy without follicle aspiration. There were no differences in mean P levels in the group of women who underwent follicle aspiration, compared with the group who did not. Women treated with CC showed higher P levels during the first week of the luteal phase. During the second week of the luteal phase P levels were similar, regardless of follicle aspiration alone or in combination with CC use. In the groups not using CC, more individual women had P levels less than 10 ng/ml. Follicle aspiration does not appear to reduce luteal phase P levels in groups of patients in the natural menstrual cycle or receiving CC. Some individual patients, however, appear to be at risk for lower P levels, particularly after follicle aspiration or general anesthesia, in the natural cycle.
D002996:Clomiphene / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008183:Luteal Phase; D006080:Ovarian Follicle; D010062:Ovulation Induction; D011374:Progesterone / Q000097:blood*; D013396:Suction; D013997:Time Factors
D002996:Clomiphene; D011374:Progesterone