[Histopathologic and biochemical evaluation of the effect of cortisone on the liver in experimental post-alcoholic liver damage in the rabbit].
Possible protective effects of cortisone in experimental post-alcohol liver damage were evaluated in relation to dose and duration of treatment. Model examinations were undertaken in 100 rabbits divided into groups of 10. No protective effect of cortisone could be demonstrated. Treatment did not alter biochemical indices of liver function. Histologic examination revealed somewhat less extensive fatty changes following chronic alcohol exposure in animals receiving 1 mg cortisone per kilogram body weight.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D003348:Cortisone / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D008111:Liver Function Tests; D011817:Rabbits
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003348:Cortisone
Histopathologische und biochemische Bewertung des Effekts von Kortison auf die Leber bei der experimentellen postalkoholischen Leberschädigung des Kaninchens.