[Effect of polyene antibiotics on the enzyme activity of prostaglandin metabolism in different layers of the kidneys of old rats].
Experiments with noninbred albino rats weighing 500-600 g showed that the level of the effect of polyene antibiotics such as amphotericin B, levorin and nystatin on the activity of the main enzymes involved in prostaglandin metabolism was different. It was demonstrated that amphotericin B had the highest effect on the activity of 15-PG-dehydrogenase and PGE2-9-ketoreductase, while the effect of sodium nystatin was the least. Both the enzymes were markedly stimulated within the first hours after the antibiotic administration. Within the following hours and days a significant decrease in the activity of the enzymes was observed, especially in the medullary and papillary kidney layers. The results suggest that the polyene antibiotics had an impairing action on the functions of the enzymes of this group.
D000375:Aging / Q000187:drug effects*; D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002174:Candicidin / Q000494:pharmacology; D006911:Hydroxyprostaglandin Dehydrogenases / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009761:Nystatin / Q000494:pharmacology; D011090:Polyenes / Q000494:pharmacology*; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D000900:Anti-Bacterial Agents; D011090:Polyenes; D011453:Prostaglandins; D009761:Nystatin; D002174:Candicidin; D000666:Amphotericin B; D006911:Hydroxyprostaglandin Dehydrogenases; C035859:15-hydroxyprostaglandin dehydrogenase; C035858:prostaglandin-E2 9-reductase
Vliianie polienovykh antibiotikov na aktivnost' fermentov metabolizma prostaglandinov v raznykh sloiakh pochek starykh krys.