Effect of exogenous lipids incorporated into the membrane of human erythrocytes on its glucose transport activity.
Addition of a phosphatidylcholine (dilinoleoyl), lysophosphatidylcholine (palmitoyl), saturated or unsaturated long-chain fatty acid (stearic or oleic) into human erythrocyte suspension caused both dose-dependent incorporation of the lipid into the membrane and inhibition of the glucose transport across the membrane. Loading to or partial removal of cholesterol from the membrane increased or decreased the transport rate, respectively. There was no correlation between the changes in the transport activity and those in cell shape caused by such alterations in the membrane lipid composition.
D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008055:Lipids / Q000494:pharmacology*; D009004:Monosaccharide Transport Proteins / Q000097:blood*; D019301:Oleic Acid; D009829:Oleic Acids / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology; D013229:Stearic Acids / Q000494:pharmacology
D001786:Blood Glucose; D008055:Lipids; D009004:Monosaccharide Transport Proteins; D009829:Oleic Acids; D010713:Phosphatidylcholines; D013229:Stearic Acids; D019301:Oleic Acid; C031183:stearic acid; D002784:Cholesterol