Macro CK type 1 as a marker for autoimmunity in coronary heart disease.
In a group of 3000 hospital patients the prevalence of immunoglobulin bound creatine kinase (macro CK type 1) was 4.3%. The relative frequency was greater in the older age categories. The highest prevalence was found in patients with rheumatic and cardiac diseases. In a group of 556 cardiac patients selected for coronary angiography a prevalence of 13.8% was observed. No significant correlation was obtained between the findings of the coronary angiography and the activity of macro CK type 1. CK MB results determined by ion-exchange or immuno-inhibition techniques in macro CK type 1 positive patients are falsely positive. Macro CK type 1 may be seen as an antigen-antibody complex against CK BB, which originates at least partly from the vascular wall.
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000378:metabolism; D001327:Autoimmune Diseases / Q000097:blood* / Q000150:complications; D003327:Coronary Disease / Q000097:blood* / Q000150:complications / Q000276:immunology; D003402:Creatine Kinase / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged
D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D007527:Isoenzymes; D003402:Creatine Kinase