Effect of sodium nitroprusside on the biophase concentration of D-tubocurarine at the neuromuscular junction.
D-Tubocurarine (DTC) at an intravenous dose of 250 micrograms/kg, or at an intra-arterial dose of 25 micrograms/kg, produced about a 50% block on the twitch tension of the indirectly stimulated tibialis anterior muscle of anaesthetized cats. The DTC-induced neuromuscular block was abolished if it was given intravenously but not intra-arterially, 30 min after the commencement of sodium nitroprusside (SNP) infusion (5 micrograms/kg per min) when there was a maximum decrease in blood pressure. The results indicate that the biophase concentration of DTC at the neuromuscular junction may be decreased as a consequence of the vasodilation induced by SNP leading to a reduced transport of the blocker to the site of action.
D000818:Animals; D002415:Cats; D004347:Drug Interactions; D005260:Female; D005292:Ferricyanides / Q000494:pharmacology*; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000378:metabolism; D009599:Nitroprusside / Q000494:pharmacology*; D014403:Tubocurarine / Q000378:metabolism / Q000494:pharmacology*
D005292:Ferricyanides; D009599:Nitroprusside; D014403:Tubocurarine