Acute effects of dihydralazine mesylate, furosemide, and metoprolol on maternal hemodynamics in pregnancy-induced hypertension.
The intervillous blood flow and other maternal hemodynamic parameters were assessed in 40 mothers with pregnancy-induced hypertension in late pregnancy before and after hypotensive treatment. Furosemide caused a significant decrease in the intervillous blood flow, whereas the effects of dihydralazine and metoprolol were both negative and positive, that is, more individual and diverse. These changes in the intervillous blood flow did not have any correlation with the changes in other maternal hemodynamic parameters. The importance of placental hemodynamic studies in the evaluation of hypotensive drugs is stressed.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002824:Chorionic Villi / Q000098:blood supply; D004078:Dihydralazine / Q000627:therapeutic use*; D005260:Female; D005665:Furosemide / Q000494:pharmacology* / Q000627:therapeutic use; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives*; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008790:Metoprolol / Q000494:pharmacology* / Q000627:therapeutic use; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000187:drug effects
D006830:Hydralazine; D005665:Furosemide; D008790:Metoprolol; D004078:Dihydralazine