title: Limb lengthening by distraction of the epiphyseal plate. A comparison of two techniques in the rabbit.
abstract: We have compared, in rabbits, two techniques of limb lengthening by distraction of the epiphyseal plate using a unilateral external fixation frame. In all cases, 14 mm of symmetrical lengthening without deviation was achieved. With rapid distraction at rates of 1 mm per day (distractional epiphyseolysis) separation of the epiphysis from the metaphysis occurred by day 7, and by day 70 almost complete ossification of the cartilage and the elongated segment was evident. In contrast, slow distraction at 0.25 mm every 12 hours (chondrodiatasis) produced hyperplasia of growth cartilage without any evidence of detachment at 28 days, the end of the distraction period. By day 70 the epiphyseal plate had returned to normal thickness with normal cellular morphology, while the lengthened segment was occupied by ossified tissue. The significance of these findings is discussed.
mesh_terms: D000818:Animals; D001852:Bone Lengthening / Q000379:methods*; D004838:Epiphyses / Q000473:pathology; D006132:Growth Plate / Q000473:pathology; D011817:Rabbits