[The spotted sterile male--a new mutation of dominant spotting on the mouse chromosome 5].
Spotted sterile male - a new mutation in mice is described (tentative symbol Ssm). White spotting on the belly, legs and tail as well as sterility in heterozygous males Ssm/+ of the B10.M strain are caused by autosomal semidominant gene Ssm. The gene is localized on the 5 chromosome: the frequency of recombination between Ssm and go is 13.6 +/- 1.6%; Ssm is closely linked to Wv. The diheterozygotes Ssm+/+Wv are darkeyed white sterile mice. The deficiency of spermatogenic epithelium cells, emptyness of seminiferous tubules as well as interstitial tissue overgrowing occurred in the testis in sterile males Ssm/+ of B10.M. The fertile hybrid males Ssm/+ are obtained in outcrossing of females Ssm/+ of B10.M with males of YT/Y, CBA/CaY, DBA/2JY, A.CA/Y strains.
D000818:Animals; D005799:Genes, Dominant; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics*; D009154:Mutation; D009929:Organ Size; D012880:Skin Pigmentation; D013737:Testis / Q000473:pathology
Spotted sterile male--novaia mutatsiia dominantnoĭ piatnistosti v 5-oĭ khromosome myshi.