Induction of interferon by transformed cells: inhibition by retinoic acid.
Retinoic acid (RA) inhibited transformed mouse L-929 and human WISH cell induction of interferon alpha/beta production by nonsensitized mouse spleen cells. The RA effect was both time and dose dependent and acted in near physiologic concentrations. The results suggest that the effect is due to a modulation of a previously described transformed cell surface associated glycoprotein IFN inducer.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis*; D007700:Kinetics; D051379:Mice; D013997:Time Factors; D014212:Tretinoin / Q000494:pharmacology*
D007370:Interferon Type I; D014212:Tretinoin