title: Pathologic explanation for postoperative obstipation in Hirschsprung's disease revealed with monoclonal antibody staining.
abstract: Until now, no pathologic explanation could be found for the postoperative obstipation occurring in some patients with intestinal aganglionosis. Twenty-two of 108 infants treated for intestinal aganglionosis suffered from postoperative obstipation. Resected material from these 22 patients and from 17 control subjects was investigated with monoclonal anti-neurofilament antibody staining. An abnormal staining pattern was revealed in 18 of the constipated patients. Consequently, this new immunohistochemical staining technic has revealed a hitherto unsuspected cause for postoperative obstipation in aganglionosis. The monoclonal antibody may provide early warning of such postoperative constipation.
mesh_terms: D000911:Antibodies, Monoclonal; D003106:Colon / Q000473:pathology; D003248:Constipation / Q000473:pathology*; D006627:Hirschsprung Disease / Q000601:surgery*; D006801:Humans; D007223:Infant; D009197:Myenteric Plexus / Q000473:pathology*; D011183:Postoperative Complications / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal