title: Pharmacological evaluation of the folklore of Sphenostylis stenocarpa.
abstract: The pharmacological effects of an aqueous extract of Sphenostylis stenocarpa seed were investigated in albino mice. Acute toxicity testing indicated the LD50 to be 570 mg/kg, i.p. The extract significantly potentiated pentobarbitone-induced sleeping time. Increasing the dose of the extract correspondingly increased the sleeping time up to a dose of 60 mg/kg i.p. The extract did not protect mice from convulsions and death resulting from the administration of strychnine (2 mg/kg, i.p.) or leptazol (100 mg/kg, s.c.).
mesh_terms: D000818:Animals; D000927:Anticonvulsants; D007928:Lethal Dose 50; D008519:Medicine, Traditional; D051379:Mice; D009549:Nigeria; D010424:Pentobarbital / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology / Q000633:toxicity; D010946:Plants, Medicinal / Q000032:analysis*
chemical_list: D000927:Anticonvulsants; D010936:Plant Extracts; D010424:Pentobarbital