Effects of equimolar doses of L-methionine, D-methionine and L-methionine-dl-sulfoxide on plasma and urinary amino acid levels in normal adult humans.
Plasma and urinary amino acid levels were measured in four normal adult subject administered equimolar quantities (0.0605 mmol/kg body wt) of L-methionine, D-methionine and L-methionine-dl-sulfoxide in a randomized crossover design. Plasma total methionine concentrations increased significantly (P less than 0.05) over base line (3.7 +/- 1.2 mumol/dl; mean +/- SD) after loading with each compound. Mean peak plasma methionine levels were 9.8 +/- 1.1, 14.4 +/- 2.3 and 5.2 +/- 1.0 mumol/dl after loading with L-methionine, D-methionine and L-methionine sulfoxide, respectively. D-Methionine accounted for the increased plasma levels seen after D-methionine loading. None of the three compounds affected plasma cystine, cysteine or taurine concentrations. Plasma methionine sulfoxide concentrations were not affected by loading with D- or L-methionine but increased significantly after ingestion of L-methionine sulfoxide. Urinary methionine excretion was 20 times higher after ingestion of D-methionine than after ingestion of L-methionine or L-methionine sulfoxide, with the increase due to D-methionine excretion. Urinary excretion of methionine sulfoxide and its N-acetyl derivatives was not significantly higher after loading with methionine sulfoxide. The data indicate that adult humans do not utilize D-methionine efficiently as a methionine source but probably do utilize L-methionine-dl-sulfoxide.
D000328:Adult; D000596:Amino Acids / Q000097:blood / Q000378:metabolism* / Q000652:urine; D003545:Cysteine / Q000097:blood; D003553:Cystine / Q000097:blood; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology* / Q000652:urine; D013237:Stereoisomerism; D013654:Taurine / Q000097:blood
D000596:Amino Acids; D013654:Taurine; D003553:Cystine; D008715:Methionine; D003545:Cysteine; C013111:methionine sulfoxide