Acute renal failure--a complication of new multidrug regimen for treatment of leprosy.
A leprosy patient who developed acute renal failure on multidrug therapy is reported. The patient had initially received a once-weekly dose of rifampin and after he had stopped taking the drug for a time, was given rifampin on a once-monthly dose schedule. He recovered completely from his acute renal failure. Kidney biopsy showed interstitial nephritis with mononuclear and eosinophilic cellular infiltrates.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D003622:Dapsone / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000209:etiology*; D004359:Drug Therapy, Combination; D006801:Humans; D007918:Leprosy / Q000188:drug therapy*; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D003622:Dapsone; D012293:Rifampin