Theophylline pharmacokinetics in pregnant and lactating rats.
As a preliminary investigation to a human study, we examined the pharmacokinetics of theophylline in pregnant and lactating rats. Three groups of female rats--pregnant, lactating, and virgin controls were injected IP with theophylline solution. Pregnant rats eliminated theophylline at a slower rate than both lactating rats and virgin controls, resulting in a longer half life (t1/2) and lower clearance. The approximate volume of distribution (aVd) and extrapolated peak concentration (Cp0) in the 3 groups were not different.
D000818:Animals; D001822:Body Burden; D005260:Female; D007274:Injections, Intraperitoneal; D007700:Kinetics; D007774:Lactation / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013806:Theophylline / Q000008:administration & dosage / Q000378:metabolism*
D013806:Theophylline