Acute intoxication due to ibuprofen overdose.
A male patient ingested a single overdose of ibuprofen (greater than 20 g). The serum ibuprofen levels were 185 mg/L (897 mumol/L) and 51.6 mg/L (250 mumol/L) at ten hours and 67 hours, respectively, after ingestion. There was also an accumulation of metabolites (2-carboxyibuprofen and 2-hydroxyibuprofen) in the plasma. The patient became unresponsive and developed severe metabolic acidosis, acute renal failure, acute liver-cell injury, acute cholestasis, and thrombocytopenia. Although his course was complicated by respiratory failure, hypotension, and upper gastrointestinal tract bleeding, the patient had complete resolution of multiple organ failure.
D000138:Acidosis / Q000139:chemically induced / Q000503:physiopathology; D058186:Acute Kidney Injury / Q000139:chemically induced / Q000503:physiopathology; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D002779:Cholestasis / Q000139:chemically induced / Q000503:physiopathology; D006801:Humans; D007052:Ibuprofen / Q000506:poisoning*; D008107:Liver Diseases / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D009102:Multiple Organ Failure / Q000503:physiopathology*
D007052:Ibuprofen