Anthelmintic activity of triclabendazole.
Triclabendazole was tested in vitro and in vivo against a range of helminths. Although in vitro activity was found against Hymenolepis diminuta (0.5 microgram/ml), Fasciola hepatica (2.5 micrograms/ml), Taenia crassiceps and Schistosoma mansoni (50 micrograms/ml), in vivo activity was only found against F. hepatica, a single oral dose of 40 mg/kg killing 99% of adult flukes in the rat. This spectrum of activity suggests a mechanism of action unlike that of other benzimidazole anthelmintics.
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002107:Caenorhabditis / Q000187:drug effects; D005210:Fasciola hepatica / Q000187:drug effects; D006373:Helminthiasis / Q000188:drug therapy*; D006376:Helminths / Q000187:drug effects*; D006926:Hymenolepis / Q000187:drug effects; D051379:Mice; D009351:Nematospiroides dubius / Q000187:drug effects; D051381:Rats; D012550:Schistosoma mansoni / Q000187:drug effects; D013621:Taenia / Q000187:drug effects; D000077682:Triclabendazole
D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole