[Action of ratibol on the blood coagulation system].
Oral ratibol (10 mg/kg) produced in rabbits a decrease of blood coagulability (increased the time of thromboelastogram reaction, reduced the activity of prothrombin complex according to Quick, tolerance to heparin and activity of factors II, VII, XIII and concentration of factor I). The drug administration (1 mg/kg) for 20 days caused at the first stage a decrease and at the second stage an increase of blood coagulability. At a single and 20-day administration ratibol enhanced the fibrinolytic activity, reduced the resistance of fibrin clot to streptokinase and increased the antithrombin activity.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D008297:Male; D010946:Plants, Medicinal; D011817:Rabbits; D013256:Steroids / Q000494:pharmacology*; D013916:Thrombelastography; D013997:Time Factors
D013256:Steroids
Deĭstvie ratibola na sistemu svertyvaniia krovi.