[Dissociation between movement disorders and EEG shifts in amphetamine-induced stereotypy in the cat].
In experiments on cats it is established that between the degree of EEG desynchronization in the sensorimotor cortex and expressiveness of the stereotype movements, a dissociation is possible which is most distinctly revealed in comparative studies of haloperidol, clozapine and metoclopramide--neuroleptics with different correlation of antipsychotic and extra-pyramidal properties. Local destruction of the ventral parts of the caudate nucleus head enhances motor disturbances resulting from amphetamine administration, but weakens its effect on the cortex. Elimination of the dorsal parts produces an opposite effect. It is suggested that the cause of the dissociation consists in different sensitivity to amphetamine of the dorsal and ventral parts of the neostriatum which are differently involved in organization of stereotype movements and EEG disturbances in amphetamine stereotypy.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D003024:Clozapine / Q000494:pharmacology; D004347:Drug Interactions; D004569:Electroencephalography; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects*
D000661:Amphetamine; D003024:Clozapine; D006220:Haloperidol; D008787:Metoclopramide
Dissotsiatsiia mezhdu dvigatel'nymi narusheniiami i sdvigami na EEG pri fenaminovoĭ stereotipii u koshek.