Non-replicative DNA synthesis detected in peripheral lymphocytes from a patient with actinic reticuloid.
A patient with actinic reticuloid has been followed with repeated investigations on DNA synthesis and immunology in blood lymphocytes. The spontaneous DNA synthesis of the patient's lymphocytes was increased to a level not previously recognized. Especially high values were observed at times when the patient was erythrodermic. The increased DNA synthesis cannot be explained by the presence of an increased number of mitotically cycling cells in the patient's blood. Normal subpopulations in blood lymphocytes were found by immunological investigations.
D000368:Aged; D004247:DNA / Q000378:metabolism; D004261:DNA Replication; D004277:DNA, Single-Stranded / Q000378:metabolism; D005434:Flow Cytometry; D006801:Humans; D008214:Lymphocytes / Q000145:classification / Q000378:metabolism*; D008297:Male; D010787:Photosensitivity Disorders / Q000097:blood*; D014466:Ultraviolet Rays
D004277:DNA, Single-Stranded; D004247:DNA