Serum and urinary oestrone sulphate in pregnancy and delivery measured by a direct radioimmunoassay.
Serum and urinary levels of oestrone sulphate in pregnancy and delivery were measured by a direct radioimmunoassay without hydrolysis. The serum and urinary oestrone sulphate increased as pregnancy progressed. The mean level of serum oestrone sulphate increased to the highest peak of 494 pmol/ml at the 35th gestational week and then decreased. The mean level of urinary oestrone sulphate increased to the highest peak of 1.28 mumol/l at the 34th gestational week and then decreased. At vaginal deliveries, the mean level of maternal peripheral serum oestrone sulphate increased hourly at as high a level as 979 pmol/ml. The mean serum level of oestrone sulphate was 204 pmol/ml in the umbilical artery and 145 pmol/ml in the umbilical vein. At Caesarean section, on the other hand, the maternal peripheral serum level of oestrone sulphate averaged 362 pmol/ml. The mean serum levels of oestrone sulphate were 90.7 pmol/ml and 171 pmol/ml in the umbilical artery and umbilical vein, respectively. These results suggest a maternal origin of oestrone sulphate in pregnancy, with fluctuations in the levels being of interest in relation to labour pain.
D002585:Cesarean Section; D036861:Delivery, Obstetric; D004970:Estrone / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D011247:Pregnancy; D011863:Radioimmunoassay / Q000379:methods
D004970:Estrone; C017296:estrone sulfate