[Partial remission of fulminant thrombotic-thrombopenic purpura (Moschcowitz syndrome) by infusion of fresh plasma].
In addition to the typical manifestations of thrombotic-thrombocytopenic purpura like thrombocytopenia, haemolysis, fever, coma and renal failure, signs of a beginning DIC could be seen in a patient after abdominal surgery. Haemostatic, cardiovascular and respiratory data are presented. Pulmonary angiography by using a Swan-Ganz-catheter revealed multiple filling defects reversible with therapy. Treatment with fresh whole blood aggravated thrombocytopenia. Daily infusions of fresh frozen plasma combined with heparinisation and antithrombin III because of DIC, induced haematologic remission. Renal failure and cerebral symptoms could not be influenced. Diagnosis, monitoring and therapy are discussed.
D001062:Appendectomy; D001780:Blood Coagulation Tests; D001803:Blood Transfusion; D003131:Combined Modality Therapy; D004211:Disseminated Intravascular Coagulation / Q000628:therapy; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010949:Plasma; D011183:Postoperative Complications / Q000628:therapy; D011652:Pulmonary Circulation / Q000187:drug effects; D011655:Pulmonary Embolism / Q000628:therapy; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis / Q000628:therapy*; D012212:Rheology; D014692:Ventilation-Perfusion Ratio
D008775:Methylprednisolone
Partielle Remission der fulminanten thrombotisch-thrombozytopenischen Purpura (Moschcowitz-Syndrom) unter Infusion von Frischplasma.