Drug overdose: changing concepts for modern drugs.
Chart review of all patients admitted over a six-month period to the University of Missouri-Columbia Medical Intensive Care Unit after intentional drug overdose revealed that the drugs ingested today are quite different from those used five to 20 years ago. I selected for review cases representative of overdose with three of the more commonly used drugs--acetaminophen, ethylene glycol, and tricyclic antidepressants.
D000082:Acetaminophen / Q000506:poisoning*; D000111:Acetylcysteine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D000873:Anthracenes / Q000506:poisoning*; D001639:Bicarbonates / Q000627:therapeutic use; D005026:Ethylene Glycols / Q000506:poisoning*; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D008376:Maprotiline / Q000506:poisoning*; D008875:Middle Aged; D013406:Suicide, Attempted; D013997:Time Factors
D000873:Anthracenes; D001639:Bicarbonates; D005026:Ethylene Glycols; D008376:Maprotiline; D000082:Acetaminophen; D000111:Acetylcysteine