Antithrombogenic heparinized polyacrylonitrile copolymer.
A new antithrombogenic polymer was synthesized by the photograft-copolymerization of methoxypolyethyleneglycol methacrylate and dimethylaminoethyl methacrylate to polyacrylonitrile containing bromine atoms, and by quaternizing and heparinizing the graft-copolymer. Hydrophilicity and heparin content of the polymer could be controlled by changing the feed ratio of the acrylates to be grafted. The heparinized polymer showed excellent mechanical and antithrombogenic properties.
D000180:Acrylic Resins / Q000138:chemical synthesis; D000818:Animals; D001672:Biocompatible Materials; D004285:Dogs; D006493:Heparin; D013314:Stress, Mechanical; D013537:Sutures; D013718:Tensile Strength; D013927:Thrombosis / Q000517:prevention & control*
D000180:Acrylic Resins; D001672:Biocompatible Materials; C010504:polyacrylonitrile; D006493:Heparin