On the mechanism of gallium accumulation in tumours. Isolation of N-hydroxypeptides.
With the use of A SEP-PAK Alumina N cartridge, peptide fractions containing the hydroxamate moiety have been isolated from tumour-tissue homogenate. It is therefore postulated that N-hydroxypeptides might play a role in the accumulation of gallium-67 in tumours. The biodistribution of several 67Ga-labelled hydroxamate peptide fractions is determined. Although their biodistribution differs from that of 67Ga-citrate no enhancement in tumour accumulation is observed indicating that they do not act like tumour-specific siderophores.
D000818:Animals; D001692:Biological Transport; D005710:Gallium Radioisotopes / Q000378:metabolism*; D006877:Hydroxamic Acids / Q000302:isolation & purification*; D008297:Male; D010455:Peptides / Q000302:isolation & purification*; D051381:Rats; D011919:Rats, Inbred Strains; D012208:Rhabdomyosarcoma / Q000378:metabolism*; D014018:Tissue Distribution
D005710:Gallium Radioisotopes; D006877:Hydroxamic Acids; D010455:Peptides