A comparison of endomyocardial disease in the rat with endomyocardial fibrosis in man.
The features of 39 cases of spontaneous endomyocardial disease occurring in the rat heart are discussed and the condition is compared with endomyocardial fibrosis occurring in man. Rat endomyocardial disease is an age-related change characterized by subendocardial proliferation of spindle cells that may progress to a lesion histologically similar to fibrosarcoma. Human endomyocardial fibrosis, on the other hand, is not age-related and shows essentially fibrohyaline changes of low cellularity preceded by the occurrence of acid mucopolysaccharides in the subendocardial region; no evidence of malignant change has ever been reported.
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000473:pathology*; D004699:Endocardium; D004719:Endomyocardial Fibrosis / Q000473:pathology*; D006331:Heart Diseases / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D051381:Rats / Q000033:anatomy & histology*; D011919:Rats, Inbred Strains