title: [Hematoporphyrin--a drug for local photodynamic therapy of endoscopically visible neoplasms].
abstract: Since the beginning of this century, the photodynamic effect of porphyrins in direction to a cytotoxic damage is well known. During the last decade hematoporphyrin, especially hematoporphyrin derivative, has been used in numerous clinical therapeutic studies for its good photosensibilizing properties. HPD builds up a concentration gradient between normal and tumor tissue from 1:10 and will be activated by light of a wave length of 405 nm. Under such condition HPD will produce a selective cytotoxic effect against tumor cells. In the international scale tumor phototherapy already turned over from an experimental phase into a clinical one. Newest reports of clinical experiences support a broader use of the method in special disciplines.
mesh_terms: D004724:Endoscopy; D006414:Hematoporphyrin Photoradiation / Q000009:adverse effects; D006415:Hematoporphyrins / Q000627:therapeutic use; D006801:Humans; D053685:Laser Therapy; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy / Q000009:adverse effects
chemical_list: D006415:Hematoporphyrins
vernacular_title: Hämatoporphyrin--Ein Mittel zur lokalen photodynamischen Therapie endoskopisch erreichbarer Neoplasmen.