title: Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence.
abstract: A cDNA clone encoding guinea pig preproglucagon has been isolated from a pancreatic cDNA library. The predicted amino acid sequence of proglucagon is highly conserved in all regions, in comparison to other mammals, except for the C-terminal portion of the 29-residue glucagon region, in which 5 amino acid substitutions have occurred. These changes may serve to offset the reduced receptor-binding potency of the highly mutated insulin in this New World species.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005934:Glucagon / Q000235:genetics*; D006168:Guinea Pigs; D009154:Mutation; D052336:Proglucagon; D011498:Protein Precursors / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D011498:Protein Precursors; D052336:Proglucagon; D004247:DNA; D005934:Glucagon