title: Prophylactic efficacy of 3-acetyl-4''-isovaleryl tylosin in a Mycoplasma gallisepticum-induced airsacculitis infection.
abstract: Formulations of 3-acetyl-4''-isovaleryl tylosin (AIV) were evaluated for oral efficacy in a Mycoplasma gallisepticum (MG) airsacculitis infection. AIV administered by gavage, feed, or water was more effective than tylosin in preventing airsacculitis. An AIV tartrate formulation administered in drinking water to chickens infected with a macrolide-sensitive or macrolide-resistant strain of MG resulted in no detection of mycoplasma in the air sacs and in MG-negative sera.
mesh_terms: D000818:Animals; D002645:Chickens; D007933:Leucomycins / Q000627:therapeutic use*; D008297:Male; D009175:Mycoplasma Infections / Q000517:prevention & control / Q000662:veterinary*; D011201:Poultry Diseases / Q000517:prevention & control*; D015645:Tylosin / Q000031:analogs & derivatives
chemical_list: D007933:Leucomycins; C031783:3-acetyl-4''-isovaleryltylosin; D015645:Tylosin