Pharmacokinetics of the bronchodilator tulobuterol in man after repeated oral doses.
Plasma levels and elimination half-life of tulobuterol, a new beta-adrenergic agonist, were determined in ten healthy male volunteers after repeated dosing with 2 mg, twice daily, for seven days. Peak plasma levels attained (2.8 +/- 0.8 ng/ml), the time to peak plasma concentration (1.0 +/- 0.3 hr) and the elimination half-life (2.4 +/- 0.4 hr) were generally unchanged from the first to the final study dose. This suggests that tulobuterol does not accumulate in plasma after repeated administration of a dose regimen known to be clinically effective.
D000284:Administration, Oral; D000328:Adult; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D013726:Terbutaline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism
D001993:Bronchodilator Agents; C010809:tulobuterol; D013726:Terbutaline