Activity of compound G2 isolated from alfalfa roots against medically important yeasts.
An antimycotic agent was isolated from roots of alfalfa and further purified to yield a nonhemolytic, homogeneous compound (G2). This compound contained considerable activity against 10 medically important yeasts. MICs obtained by both agar and broth dilution methods ranged from 3 to 15 micrograms/ml. Compound G2 was fungicidal at a relatively low concentration for nine different species of yeasts tested (minimum fungicidal concentrations ranged between 6 and 24 micrograms/ml). The considerable stability of compound G2 and its strong inhibitory and fungicidal activity against a broad range of yeasts suggest that after further development it might be useful as an active agent in the treatment of mycotic infections.
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D003470:Culture Media; D005260:Female; D006863:Hydrogen-Ion Concentration; D000455:Medicago sativa; D051379:Mice; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology; D014315:Triterpenes / Q000494:pharmacology*; D015003:Yeasts / Q000187:drug effects*
D000935:Antifungal Agents; D003470:Culture Media; D010936:Plant Extracts; D014315:Triterpenes; C049077:medicagenic acid-3-O-glucopyranoside