Hormonal regulation of sodium-fluid balance and some hemodynamic parameters in the rat. I. Effect of indomethacin and vasopressor-vasodepressor hormonal systems in the regulation of blood pressure.
A study based on sodium depletion, sodium loading and indomethacin treatment was conducted on rats. After sodium depletion significant activation of renin-angiotensin-aldosterone system and insignificantly increased kallikrein excretion without changes in prostaglandin excretion and plasma vasopressin were found. After sodium loading significant decrease of PRA (-83%), prostaglandin excretion (-34%), insignificant decrease of aldosterone and kallikrein excretion and significant increase of vasopressin (134%) were established. Indomethacin (5 mg/kg b.w.) administered for 8 days showed an antidiuretic and an anti-natriuretic effect, inhibition of PG-synthesis by 57% and of PRA by 68%, a significant increase of plasma volume (21%), blood volume (24%) and mean arterial pressure (14%). The relationships between vasopressor and vasodepressor hormonal systems in the rat are discussed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006728:Hormones / Q000502:physiology*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011453:Prostaglandins / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012084:Renin-Angiotensin System; D012964:Sodium / Q000502:physiology*; D014667:Vasopressins / Q000097:blood; D014882:Water-Electrolyte Balance
D006728:Hormones; D011453:Prostaglandins; D014667:Vasopressins; D012964:Sodium; D007213:Indomethacin