title: Intrathecal morphine for post-thoracotomy pain.
abstract: We wished to investigate possible differences in the duration of postoperative analgesia and the incidence of respiratory depression after the intrathecal injection in the lumbar area of 10 micrograms/kg morphine in hypobaric and hyperbaric solution for relief of post-thoracotomy pain. Twenty-nine patients received morphine plus dextrose (hyperbaric) and 21 received morphine in preservative-free normal saline. The duration of analgesia was longer with the morphine in the normal saline group than in the hyperbaric group (P less than 0.04). One patient developed delayed respiratory depression. Our data support the use of morphine in normal saline mixtures for greater duration of analgesia after thoracic operations.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D005950:Glucose Solution, Hypertonic; D006801:Humans; D007275:Injections, Intravenous; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D010149:Postoperative Pain / Q000188:drug therapy*; D013046:Specific Gravity; D013903:Thoracic Surgery; D013997:Time Factors
chemical_list: D005950:Glucose Solution, Hypertonic; D009020:Morphine; D005283:Fentanyl