title: Juvenile onset pernicious anemia, partial intestinal villous atrophy, ulcerative colitis, and squamous metaplasia of the stomach.
abstract: We report a case of a 13-yr-old white boy with juvenile onset pernicious anemia in association with IgG deficiency. He had marked gastric atrophy, intestinal metaplasia of the stomach, and an intractable antral ulcer that required surgery. In addition, his gastric mucosa showed evidence of a progressive squamous metaplasia. Diffuse squamous metaplasia of the stomach, a very rare gastric lesion, has not previously been described either in association with pernicious anemia, atrophic gastritis, or hypogammaglobulinemia. This patient also has ulcerative colitis involving the entire colon and partial villous atrophy noted on small intestinal biopsy.
mesh_terms: D000752:Anemia, Pernicious / Q000150:complications* / Q000276:immunology / Q000473:pathology; D001284:Atrophy / Q000209:etiology; D003093:Colitis, Ulcerative / Q000209:etiology*; D004406:Dysgammaglobulinemia / Q000150:complications; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D017099:IgG Deficiency; D007223:Infant; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D008679:Metaplasia / Q000209:etiology