[Therapeutic effect of lipids from the Far Eastern sardine (Sardinops sagax melanostica) in experimental hypercholesterolemia in rats].
Hypercholesterolemia was experimentally induced in rats which received diets with a high fat content (66% calories) and cholesterol loading (2.5% of ration). The therapeutic effect of lipids isolated from quick-frozen Far East sardines was tested on rats given 500 mg lipids daily. The content of the blood serum lipid fractions in the test animals decreased under the action of the sardines' lipids: the total cholesterol level dropped by 23%, beta-lipoprotein cholesterol by 29%, triglycerides by 15%; the content of beta-lipoproteins became normal. The blood coagulation time was diminished in rats receiving diets with a high content of fat and cholesterol, as compared to that in control animals; and it increased under the action of sardines' lipids. A conclusion has been made on the hypolipidemic property of Far East sardines' lipids that produce a therapeutic effect on the blood lipid metabolism in animals.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005399:Fishes; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D008055:Lipids / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D013997:Time Factors
D008055:Lipids
Terapevticheskiĭ éffekt lipidov dal'nevostochnoĭ sardiny pri éksperimental'noĭ giperkholesterinemii u krys.