The metabolism of 3-aminobiphenyl and 3-acetamidobiphenyl in vitro.
The metabolism of 3-aminobiphenyl (3-ABP) and 3-acetamidobiphenyl (3-AABP) has been studied using fortified rat liver microsomal preparations. Metabolites in concentrates of ether extracts from hepatic microsomal preparations were analysed by TLC and GLC. The metabolites were characterised by a comparison of their chromatographic characteristics with synthetic compounds and response to detection reagents. 3-ABP appeared to be hydroxylated predominantly at the 2- and 4-ortho positions and to a minor extent at the 6-position, whereas 3-AABP was converted to 3-acetamido-6-hydroxybiphenyl as the major metabolite. 3-ABP was also converted to the corresponding hydroxylamine, nitroso and nitro compound although the latter may have arisen via a non enzymic process.
D000611:Aminobiphenyl Compounds / Q000378:metabolism*; D000818:Animals; D002273:Carcinogens / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000611:Aminobiphenyl Compounds; D002273:Carcinogens; C049663:3-acetamidobiphenyl; C049671:3-aminobiphenyl