Does cholecystokinin potentiate dopamine action in the nucleus accumbens?
Extracellular single unit recording and microiontophoretic techniques were used to determine whether sulfated cholecystokinin octapeptide (CCK-8S) potentiates the inhibitory action of dopamine (DA) on neurons in the nucleus accumbens of rats. The results show that CCK-8S attenuated, rather than enhanced the action of DA. The interaction between CCK-8S and DA does not appear to be specific because similar antagonizing actions between CCK-8S and serotonin were observed. In addition to opposing the inhibitory effects of DA and serotonin, CCK-8S potentiated the activation of glutamate. It is concluded that CCK-8S and DA exerted their actions independently via depolarizing and hyperpolarizing the neuronal membrane of the NAc neurons, respectively.
D000818:Animals; D002766:Cholecystokinin / Q000008:administration & dosage* / Q000378:metabolism; D004298:Dopamine / Q000008:administration & dosage* / Q000378:metabolism; D004347:Drug Interactions; D007478:Iontophoresis; D008297:Male; D009474:Neurons / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000502:physiology*
D002766:Cholecystokinin; D004298:Dopamine