Influence of H-2 haplotypes on poly IC induction of xanthine oxidase and poly IC induced decreases in P-450 mediated enzyme activities.
Polyriboinosinic-polyribocytidylic acid (poly IC), a potent interferon inducer, induced xanthine oxidase 24 hours after treatment with 5 mg/kg ip to different degrees among four H-2 congenic mice (P less than 0.05): B10 (H-2b: 236 +/- 27% of the control value) greater than B10.RIII (H-2r: 171 +/- 29%) = B10.F (H-2n: 161 +/- 12%) greater than B10.BR (H-2k: 136 +/- 15%). Aryl hydrocarbon hydroxylase (AHH) activity showed an inverse correlation with inducibility of xanthine oxidase (r = -0.71, P less than 0.01). However, there were no significant changes in activities of heme pool associated enzymes, such as catalase, tryptophan pyrrolase and d-aminolevulinic acid synthase in these mice. H-2 haplotype seems to have an influence on poly IC induction of xanthine oxidase thereby causing a decrease in AHH.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006238:Haploidy; D006418:Heme / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011070:Poly I-C / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000201:enzymology; D014969:Xanthine Oxidase / Q000096:biosynthesis*
D007527:Isoenzymes; D006418:Heme; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; D014969:Xanthine Oxidase; D011070:Poly I-C