[Action of ifenprodil tartrate in obliterative arteriopathies of the lower limbs. Combined studies using proximal blood flow and distal transcutaneous oxygen pressure].
A simultaneous analysis of both the variations of the flow in the stenosis artery and the distal PO2, was carried out during an injection of an alpha-blocker: the Tartrate d'Ifenprodil, on twenty-five patients afflicted with occlusive disease of the lower limbs requiring surgery. The measurements were taken under general anaesthesia, before any surgical operation, the hemodynamic and ventilatory balance being monitored by radial manometry and arterial gas analysis. We observe an increase of proximal arterial flow and at the same time an improvement of the distal TcPO2. Moreover, the variations of microcirculation flow measured by TcPO2 are correlated with proximal flow variations, this relation: delta TcPO2 = K delta Q + A is more true in the first and the second stages of Fontaine. With the same (Tartrate d'Ifenprodil) posology, the distal benefit measured by transcutaneous oximetry is less important in advanced stages compared with other stages (everything else being equal). The transcutaneous measurement of the distal oxygen pressure, allows an objective view of microcirculatory improvement obtained by a vasoactive substance (ifenprodil tartrate) considering the specific nature of each patient arteriopathy.
D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D001785:Blood Gas Monitoring, Transcutaneous; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D012039:Regional Blood Flow; D014665:Vasodilator Agents / Q000627:therapeutic use*
D010880:Piperidines; D014665:Vasodilator Agents; C010739:ifenprodil
Action du tartrate d'ifenprodil dans l'artériopathie oblitérante des membres inférieurs. Mesures couplées par débitmétrie proximale et pression d'oxygène transcutanée distale.