title: Some transition metal chelates of 8-hydroxyquinoline-5-sulfonamides as possible drugs.
abstract: Fe(II), Fe(III), Co(II), and Ni(II) chelates with three quinolinol sulfonamides have been prepared and characterized. Characterization of the solids so obtained was accomplished by elemental analysis, electronic and ir spectra, and conductivity measurements. It was found that the sulfonamide ligands act as monobasic bidentate ON donors. The bonding sites are ascertained, and the complexes were all six-coordinate assuming a distorted octahedral geometry. It was identified that the metal chelates possess enhanced antibacterial and antifungal activities relative to the free ligands.
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D000935:Antifungal Agents / Q000138:chemical synthesis*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013449:Sulfonamides