title: Modifications in the histochemical and biochemical changes in tenotomized rat soleus by denervation.
abstract: Response of tenotomized rat soleus muscle to denervation performed at different time intervals, has been investigated. Tenotomized muscles showed typical central core lesions seven days post-operatively. These were not observed in m-ATPase stained sections of simultaneously denervated and tenotomized muscles, and muscles denervated 24 h after tenotomy. Central core lesions were not prevented in muscles denervated 28 h after tenotomy, indicating that tenotomy effects responsible for central lesions are completed by this time. Myosin light chain pattern of muscles denervated 28 h after tenotomy, and tenotomized only were similar showing increased LC3/LC1 ratio. Simultaneously denervated and tenotomized muscle however showed all the three light chains relatively equal in quantity. The results suggest that elimination of neural activation within 28 h prevents myofibrillar loss and minimized other changes which occur due to tenotomy.
mesh_terms: D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D006651:Histocytochemistry; D008297:Male; D009121:Muscle Denervation; D009132:Muscles / Q000378:metabolism* / Q000473:pathology; D009218:Myosins / Q000378:metabolism; D051381:Rats; D013710:Tendons / Q000502:physiology
chemical_list: D009218:Myosins