[Update on prolactin].
Normal serum prolactin levels range from 5 to 20 ng/ml (circadian rhythm, effect of stress, relation with estrogen secretion). Neuroleptics increase serum prolactin levels. Normal concentrations are restored within 24 to 48 hours of discontinuation of the drug. When neuroleptics are given for a long period of time, serum prolactin concentrations fall gradually to low levels. There is no conclusive evidence that prolactin plays a role in breast tumors in women. Epidemiologic studies have shown that neuroleptics are not responsible for increased incidences of these tumors.
D000818:Animals; D001943:Breast Neoplasms / Q000209:etiology; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications; D008297:Male; D051379:Mice; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism*; D014149:Tranquilizing Agents / Q000009:adverse effects
D014149:Tranquilizing Agents; D011388:Prolactin
Mise au point sur la prolactine.