High frequency of c-K-ras activation in 3-methylcholanthrene-induced mouse thymomas.
Thymic lymphomas were induced in RJF mice by percutaneous application of 3-methylcholanthrene (MCA). DNAs from 83% of the tumors analyzed contained a transforming c-K-ras gene. The high frequency of c-K-ras oncogene activation in response to MCA seems to favor the concept that the activation of c-K-ras is related to the specificity of the mutagenic effect of MCA.
D000818:Animals; D008748:Methylcholanthrene; D051379:Mice; D009857:Oncogenes; D013945:Thymoma / Q000235:genetics*; D013953:Thymus Neoplasms / Q000235:genetics*
D008748:Methylcholanthrene