title: Role of progestogens in the prevention of breast cancer.
abstract: The incidence of breast cancer has continued to decrease each year at Wilford Hall United States Air Force Medical Center with the ever-increasing use of combined progestogen-oestrogen replacement therapy over the past 12 yr. By 1983, the overall incidence of breast cancer had fallen to 53.9:100 000. The lowest rate for the 9 yr of a prospective study to 1983 was seen among the oestrogen-progestogen users (66.8:100 000) although it was also slightly reduced in both the unopposed oestrogen users (142.3:100 000 and the oestrogen vaginal cream users (116.3:100 000). The incidence was significantly lower in both the oestrogen-progestogen users and the oestrogen users (P less than or equal to 0.01) as compared with untreated women (343.5:100 000). These data further strengthen the growing evidence that the addition of progestogen to oestrogen decreases the risk of mammary malignancy.
mesh_terms: D001943:Breast Neoplasms / Q000517:prevention & control*; D004338:Drug Combinations; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008593:Menopause; D011372:Progestins / Q000627:therapeutic use*; D011446:Prospective Studies
chemical_list: D004338:Drug Combinations; D004967:Estrogens; D008074:Lipoproteins; D011372:Progestins