PD 116,152, a new phenazine antitumor antibiotic. Structure and antitumor activity.
A new, highly substituted phenazine with antitumor activity was isolated from the culture broth of a Streptomyces sp. This compound, whose structure was determined by spectroscopic methods and verified by X-ray diffraction analysis, was found to be methyl 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylate.
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D008961:Models, Structural; D010619:Phenazines / Q000494:pharmacology; D014961:X-Ray Diffraction
D000903:Antibiotics, Antineoplastic; D010619:Phenazines; C048268:PD 116152