Evaluation of the relationship between chemical and biological monitoring of low-level lead poisoning.
Blood lead levels, together with delta-aminolevulinic acid dehydratase activity determinations have been measured on rats dosed with up to 1000 ppm lead acetate in their drinking water for periods up to 5 weeks. Despite evidence of a compensation mechanism developing in the enzyme determinations, enzyme activity ratios, if properly chosen, still correlate reasonably well (r = 0.87) with blood lead levels. Activity ratios using data on the shoulders of pH-activity profiles (e.g. activity ratios of 6.4 and 7.2), however, give much less satisfactory correlations. These data provide a more stringent test of the chemical monitor-biological monitor correlation than has previously been possible.
D000818:Animals; D004796:Clinical Enzyme Tests; D004912:Erythrocytes / Q000201:enzymology; D006400:Hematocrit; D006863:Hydrogen-Ion Concentration; D007854:Lead / Q000097:blood*; D007855:Lead Poisoning / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D000623:Porphobilinogen Synthase / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
D007854:Lead; D000623:Porphobilinogen Synthase