Epygid: a new Soviet antioxidant promoted the selective inhibition of membrane-dependent protein synthesis in the brain.
Intraperitoneal injection of different amounts of Epygid (2-ethyl-6-methyl-3-oxypyridine) to 3- and 18-month-old rats led to significant reduction of translating activity in vitro of membrane-bound polysomes of brain cells, but not of free polysomes, more so for bound polysomes from 18-month-old animals than those from 3 months old. Separation of polysomes from membranes by Triton X-100 resulted in restoration of template activity to the level of free polysomes. The phenomenon may be related to incorporation of Epygid into the membranes of endoplasmic reticulum which contain a part of cell polysomes on their surface.
D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D008297:Male; D010847:Picolines / Q000494:pharmacology*; D011132:Polyribosomes / Q000378:metabolism; D014176:Protein Biosynthesis / Q000187:drug effects; D051381:Rats; D012270:Ribosomes / Q000378:metabolism*
D000975:Antioxidants; D010847:Picolines; C039550:2-methyl-6-ethyl-3-hydroxypyridine