10-Thiastearic acid inhibits both dihydrosterculic acid biosynthesis and growth of the protozoan Crithidia fasciculata.
10-Thiastearic acid is a specific inhibitor of the biosynthesis of dihydrosterculic acid (9,10-methyleneoctadecanoic acid) in the trypanosomatid protozoan Crithidia fasciculata. A 50% inhibition of the biosynthesis of dihydrosterculate is observed in the presence of 4 microM 10-thiastearate in the protozoan growth medium, but little effect is seen on the distribution of the other fatty acids. In addition, the growth of the protozoa is slowed by the presence of 10-thiastearate, with 50% growth inhibition produced at about 10 microM. A possible mechanism of this inhibition and the implication of this result with regard to the design of antiprotozoal agents are discussed.
D002849:Chromatography, Gas; D003421:Crithidia / Q000187:drug effects / Q000254:growth & development*; D005227:Fatty Acids / Q000096:biosynthesis*; D013229:Stearic Acids / Q000494:pharmacology*
D005227:Fatty Acids; D013229:Stearic Acids; C050048:10-thiastearic acid; C029355:dihydrosterculic acid