title: Caustic sclerosing cholangitis. A complication of the surgical treatment of hydatid disease of the liver.
abstract: In five patients, sclerosing cholangitis developed after the surgical treatment of hydatid cyst of the liver. The cyst communicated with the biliary tree, and a scolicidal solution (2% formaldehyde in two patients and 20% sodium chloride in three) was injected into the cyst. Cholangiography showed strictures affecting the intrahepatic biliary tree in two and both the intrahepatic and extrahepatic biliary tree in three. Sclerosing cholangitis in these patients was likely to result from the caustic effect of the scolicidal solution having diffused from the cyst into the biliary tree. We propose to designate this entity "caustic sclerosing cholangitis". Because of the risk of this complication, and the unproved efficacy of intracystic injection of a scolicidal solution in preventing the dissemination of the parasite, we recommend that this maneuver be abandoned in the surgical treatment of hydatid disease of the liver.
mesh_terms: D000328:Adult; D000368:Aged; D002424:Caustics / Q000009:adverse effects*; D002758:Cholangiography; D002761:Cholangitis / Q000139:chemically induced*; D001651:Cholestasis, Extrahepatic / Q000139:chemically induced; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced; D004444:Echinococcosis, Hepatic / Q000601:surgery*; D005557:Formaldehyde / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012598:Sclerosis; D012965:Sodium Chloride / Q000009:adverse effects*
chemical_list: D002424:Caustics; D005557:Formaldehyde; D012965:Sodium Chloride