Paracetamol metabolism in pregnancy.
Paracetamol disposition was studied in groups of pregnant and non-pregnant women of comparable age. Paracetamol apparent oral clearance was 58% higher and elimination half-life was 28% lower in the pregnant women compared to the control group. The higher clearance in the pregnant women was due to increased activity of the glucuronidation (75% higher) and oxidative (88% higher) pathways of paracetamol metabolism. There was no difference between the two groups in paracetamol sulphation or renal clearance of unchanged drug.
D000082:Acetaminophen / Q000378:metabolism*; D000328:Adult; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008657:Metabolic Clearance Rate; D011247:Pregnancy / Q000378:metabolism*; D011263:Pregnancy Trimester, Third; D013431:Sulfates / Q000378:metabolism
D005965:Glucuronates; D013431:Sulfates; D000082:Acetaminophen; D005978:Glutathione