Pre-training adrenaline recovers the amnestic effect of Met-enkephalin in demedullated rats.
The intracerebroventricular administration of 25 ng of Met-enkephalin causes retrograde amnesia for a shuttle avoidance task in intact rats. In demedullated rats, this effect of Met-enkephalin was lost. Intraperitoneal injection of 1.2 micrograms/kg adrenaline recovered the amnestic effect of Met-enkephalin. These results confirm the idea that the amnestic effect of Met-enkephalin is centrally mediated and that adrenal enkephalins do not seem to be important to the amnestic effect of Met-enkephalin since adrenaline recovers this effect in demedullated rats.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D008526:Medulla Oblongata / Q000502:physiology*; D008568:Memory / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D004744:Enkephalin, Methionine; D004837:Epinephrine