title: Propionibacterium acnes infection in neurosurgical patients. Experience with high-dose penicillin therapy.
abstract: Propionibacterium acnes is an underestimated but significant cause of cerebrospinal fluid (CSF) infection after neurosurgical procedures and in the presence of prosthetic devices. The most effective therapy for such infections has not been defined. We report here our experience with the use of high-dose penicillin in the treatment of six patients with postoperative infection which was caused by P. acnes. All patients received 3-4 million units of penicillin by the intravenous route every four hours, in combination with surgical drainage and removal of prosthetic devices where appropriate. All but one of the patients recovered from their infection. The remaining patient responded to penicillin but died of a massive intraventricular haemorrhage after 12 days. Isolates of P. acnes had minimal inhibitory concentrations to penicillin that ranged from 0.03-0.12 mg/L. No adverse reactions to penicillin were recorded. We conclude that high-dose intravenous penicillin therapy, in combination with surgical drainage and removal of foreign bodies, constitutes appropriate therapy for CSF infections that are due to P. acnes.
mesh_terms: D003131:Combined Modality Therapy; D004322:Drainage; D004334:Drug Administration Schedule; D006801:Humans; D007275:Injections, Intravenous; D009493:Neurosurgery; D010406:Penicillins / Q000008:administration & dosage*; D011425:Propionibacterium acnes / Q000302:isolation & purification; D013530:Surgical Wound Infection / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D010406:Penicillins