title: [Sclerotherapy of varices and protein C deficiency].
abstract: The appearance of relapsing venous thrombosis after sclerosis of varices in a woman aged 30 led us to discover a quantitative protein C deficiency, found in her father and 4 of her brothers and sisters. The transmission mode is autosomal and dominant. Within this family, 6 subjects are affected, 4 showing symptoms, clearly showing the heterogeneity of the clinical manifestation of the deficiency. Dealing with the special problem of pregnancy in women with the biological disorder, one ought to consider the literature on the subject, showing the large occurrence of ante- and post-natal accidents. The treatments of thromboembolic complications is based on the use of heparin administered appropriately through antivitamins K for a period which is till to be defined. In asymptomatic subjects, a preventive anticoagulant treatment is recommended in all circumstances likely to encourage the relapse of thrombosis.
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D001798:Blood Proteins / Q000172:deficiency*; D002648:Child; D005260:Female; D006023:Glycoproteins / Q000172:deficiency*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy; D011486:Protein C; D012008:Recurrence; D012597:Sclerosing Solutions / Q000008:administration & dosage / Q000009:adverse effects*; D013924:Thrombophlebitis / Q000188:drug therapy / Q000209:etiology; D014648:Varicose Veins / Q000150:complications / Q000235:genetics / Q000628:therapy*; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D001798:Blood Proteins; D006023:Glycoproteins; D011486:Protein C; D012597:Sclerosing Solutions; D014812:Vitamin K; D006493:Heparin
vernacular_title: Sclérose de varices et déficit en protéine C.