cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines.
The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones and the gene localized to chromosome 7. The protein shows extensive homology to the PDGF B-chain precursor. Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.
D001483:Base Sequence; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002906:Chromosomes, Human, 6-12 and X; D004247:DNA; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D008970:Molecular Weight; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D012333:RNA, Messenger
D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger; D004247:DNA