title: [Hormonal principles in normal and pathologic somatic sexual development].
abstract: Normal sexual development is the consequence of three sequential interrelated processes: establishment of genetic, gonadal and somatic sex. It is the terminal phase of sexual differentiation--the translation of gonadal into somatic sex, which is governed by the presence or absence of both testosterone and Müllerian-inhibiting hormone and of dihydrotestosterone, which is formed in its respective target tissues. Thus, despite a testis, somatic male sexual differentiation will proceed to a normal male phenotype only if all three hormones are synthesized and act during a critical period of uterine development. Many clinically distinct syndromes are the results of abnormalities in the synthesis or action of the above-mentioned hormones; these syndromes are described in detail. In contrast to male somatic differentiation, female somatic development is independent of these hormones.
mesh_terms: D000293:Adolescent; D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000503:physiopathology; D000735:Androstenedione / Q000502:physiology; D000818:Animals; D054304:Anti-Mullerian Hormone; D002648:Child; D002675:Child, Preschool; D013196:Dihydrotestosterone / Q000378:metabolism; D012734:Disorders of Sex Development / Q000503:physiopathology*; D004967:Estrogens / Q000502:physiology; D005260:Female; D005865:Gestational Age; D006023:Glycoproteins; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006131:Growth Inhibitors; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010641:Phenotype; D011247:Pregnancy; D011944:Receptors, Androgen / Q000502:physiology; D012730:Sex Chromosomes / Q000502:physiology; D013577:Syndrome; D013735:Testicular Hormones / Q000502:physiology; D013739:Testosterone / Q000502:physiology; D014770:Virilism / Q000503:physiopathology
chemical_list: D004967:Estrogens; D006023:Glycoproteins; D012739:Gonadal Steroid Hormones; D006131:Growth Inhibitors; D011944:Receptors, Androgen; D013735:Testicular Hormones; D013196:Dihydrotestosterone; D013739:Testosterone; D000735:Androstenedione; D054304:Anti-Mullerian Hormone
vernacular_title: Hormonelle Grundlagen der normalen und pathologischen somatischen Sexualentwicklung.