[Immunoreactivity and the effect on it of the 3-HAA antigen in patients with gastrointestinal tumors].
3-hydroxyanthranilic acid(3-HAA)-antigen, commonly identifiable in blood serum of gastrointestinal cancer patients was shown to influence immunologic vigor in vitro. Treatment of patients' cultured lymphocytes with 3-HAA-antigen and PHA produced a statistically significant inhibition of blastogenic reaction of lymphocytes. Exposure to the said antigen gave a positive leukocyte migration inhibition test both in patients and controls. Antibodies against 3-HAA-antigen were identified in patients' serum by complement fixation test. Blood serum levels of the said antibodies and IgG were found to be in correlation with blood-3-HAA-antigen concentration. Patients' serum revealed an immunosuppressive activity inhibiting formation of antibody-producing cells to sheep erythrocytes in Jerne assay in mice.
D015095:3-Hydroxyanthranilic Acid / Q000276:immunology*; D000906:Antibodies / Q000032:analysis; D000941:Antigens / Q000276:immunology*; D005770:Gastrointestinal Neoplasms / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D062367:ortho-Aminobenzoates / Q000276:immunology*
D000906:Antibodies; D000941:Antigens; D062367:ortho-Aminobenzoates; D015095:3-Hydroxyanthranilic Acid
Issledovanie immunoreaktivnosti i vliianiia na nee 3-OAK-antigena u bol'nykh opukholami zheludochno-kishechnogo trakta.