Studies on the structural requirements for synthetic formyl peptide chemoattractants.
Seven small molecular weight new peptides related to the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (CHO-Met-Leu-PheOH) have been prepared by classical peptide synthesis. Compounds were prepared to evaluate the requirements at the C-terminal Phe group/ Each analogue tested for its ability to induce lysosomal enzyme release from human neutrophils.
D006801:Humans; D008247:Lysosomes / Q000187:drug effects; D008970:Molecular Weight; D009113:Muramidase / Q000097:blood*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D009504:Neutrophils / Q000201:enzymology*; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic / Q000378:metabolism; D013329:Structure-Activity Relationship
D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009113:Muramidase