[Effect of the carcinogenic tyrosine metabolite p-hydroxyphenyllactic acid on the ascorbic acid concentration in the organs and blood of mice].
The effect of cancerogenic tyrosine metabolite, p-hydroxyphenyllactic acid, on the concentration of ascorbic acid in the organs and blood of mice has been studied. p-Hydroxyphenyllactic acid was demonstrated to decrease considerably ascorbic acid concentration in the liver, adrenal glands and blood of mice. The above phenomenon and the previous data on tyrosine aminotransferase induction by p-hydroxyphenyllactic acid suggest the existence of two interdependent mechanisms of cancerogenic tyrosine metabolite (p-hydroxyphenyllactic acid) accumulation.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D002273:Carcinogens / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010666:Phenylpropionates / Q000494:pharmacology*; D014018:Tissue Distribution; D014443:Tyrosine / Q000378:metabolism*
D002273:Carcinogens; D010666:Phenylpropionates; C001418:4-hydroxyphenyllactic acid; D014443:Tyrosine; D001205:Ascorbic Acid
Vliianie kantserogennogo metabolita tirozina p-oksifenilmolochnoĭ kisloty na kontsentratsiiu askorbinovoĭ kisloty v organakh i krovi mysheĭ.