[Disordered repair processes in patients with gouty nephropathy].
The reparation activity in lymphocytes using the DNA reparative synthesis test was assessed in 18 patients: 10 suffering from primary gout with renal involvement, 6 suffering from chronic nephritis with hyperuricemia, 1 with hyperuricosuria and 1 with systemic lupus erythematosus. Inhibition of the DNA reparative synthesis was noted in 15 patients (deep in 11 patients and partial in 4). A degree of synthesis inhibition did not depend on renal function and uricemia value. An opportunity of the use of reparation activity as a criterion of the development of disease even at the premorbid stage was discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects; D004260:DNA Repair / Q000528:radiation effects; D005260:Female; D006073:Gout / Q000097:blood*; D006801:Humans; D007674:Kidney Diseases / Q000097:blood*; D008214:Lymphocytes / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D014466:Ultraviolet Rays
D004247:DNA
Narushenie protsessov reparatsii u bol'nykh podagricheskoĭ nefropatieĭ.