Tifluadom's effects under electric shock titration and tail-immersion procedures in squirrel monkeys.
The analgesic efficacy of the kappa-opioid benzodiazepine, tifluadom, was examined in squirrel monkeys using electric shock titration and tail-immersion procedures. Tifluadom produced dose-dependent increases in the shock intensity that maintained responding under the shock titration schedule without substantially decreasing response rates. Tifluadom also increased the latency of tail-withdrawal from 55 degrees C water. Naloxone attenuated tifluadom's effects under both procedures. These results extend previous reports of tifluadom's analgesic characteristics and suggest that the tail-immersion procedure is a useful analgesic assay in squirrel monkeys.
D000698:Analgesia; D000818:Animals; D001569:Benzodiazepines; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D006358:Hot Temperature; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D012453:Saimiri; D013623:Tail
D001569:Benzodiazepines; D009270:Naloxone; C035470:tifluadom