Caerulein and cholecystokinin reverse experimental hemorrhagic shock.
Intravenously injected cholecystokinin octapeptide (CCK-8) (5-20/micrograms/kg) and caerulein (1.25-10/micrograms/kg) caused a prompt, dose-dependent and sustained improvement in blood pressure, pulse amplitude and survival in rats subjected to otherwise invariably fatal hemorrhagic shock.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002108:Ceruletide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D007275:Injections, Intravenous; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000188:drug therapy*; D012844:Sincalide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D002108:Ceruletide; D012844:Sincalide