title: [Determination of the digoxin concentration in the blood plasma of patients with cardiopulmonary failure].
abstract: Digoxin was used for 2-4 weeks in a combined treatment of 98 patients with cardiopulmonary insufficiency. Blood plasma digoxin concentration was measured in 65 patients. A clinical improvement accompanied with positive hemodynamic changes, an improvement of myocardial contractility, a decrease of pulmonary hypertension was observed in 88% of patients. The relationship between a clinical effect and the drug dose was found. Correlation between blood digoxin concentration, stage of circulatory insufficiency and toxic manifestations was revealed.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001991:Bronchitis / Q000150:complications; D002908:Chronic Disease; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011660:Pulmonary Heart Disease / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D013997:Time Factors
chemical_list: D004077:Digoxin
vernacular_title: Opredelenie kontsentratsii digoksina v plazme krovi bol'nykh s legochno-serdechnoĭ nedostatochnost'iu.