[Effect of methylglyoxal bis(guanylhydrazone) in combination with antifolic acid preparations on the biochemical indices and growth of Pliss lymphosarcoma in rats].
It was shown in experiments with Pliss' lymphosarcoma in rats that antifolates--cis-2,5-bis (aminohydroxymethyl)-piperazine-3,6-dione and methotrexate--cause tumor cell spermidine level to drop. Also, treatment with antifolates prevented the undesirable accumulation of S-adenosylmethionine in tumor cells induced by methyl-glyoxal-bis (guanylhydrazone) which inhibits polyamine biosynthesis. In chemotherapeutic experiments with rat lymphosarcoma, antifolates markedly potentiated the antitumor effect of methylglyoxal-bis (guanylhydrazone). The data suggest that the combination of polyamine biosynthesis inhibitors such as methylglyoxal-bis (guanylhydrazone) and alpha-difluoromethylornithine and antifolates may be useful in tumor chemotherapy.
D012437:Adenosylmethionine Decarboxylase / Q000378:metabolism; D000818:Animals; D003523:Cycloserine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005493:Folic Acid Antagonists / Q000627:therapeutic use*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008935:Mitoguazone / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D011073:Polyamines / Q000037:antagonists & inhibitors; D051381:Rats; D012435:S-Adenosylhomocysteine / Q000378:metabolism; D013997:Time Factors
D005493:Folic Acid Antagonists; D011073:Polyamines; C048253:cycloserine diketopiperazine; D003523:Cycloserine; D012435:S-Adenosylhomocysteine; D012437:Adenosylmethionine Decarboxylase; D008935:Mitoguazone; D008727:Methotrexate
Vliianie metilglioksal'-bis(guanilgidrazona) v kombinatsii s antifolievymi preparatami na nekotorye biokhimicheskie pokazateli i rost limfosarkomy Plissa u krys.