[The action of phenylmercuriacetate and nitrate in combined application in rats: the thyroid gland, liver enzymes and morphologic findings in the brain and kidney].
Rats were exposed to nitrate (NO3-) in drinking water, to phenylmercuryacetate (PMA) by gavage and to NO3- and PMA together during 4 different experiments. PMA impaired kidneys, NO3- thyroid gland, and NO3- and PMA together both organs. In the last case a synergistic effect on the thyroid gland was shown. The lowest effective concentration of NO3- was 40 mg/l. It resulted in histomorphological changes of the thyroid epithelial cells. That low effective dose of NO3- and possible synergistic effects should give a further impulse to take into consideration not only a low iodide intake but also goitrogenic environmental chemicals when evaluating the endemic goitre prevalence.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004357:Drug Synergism; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010662:Phenylmercuric Acetate / Q000633:toxicity*; D010663:Phenylmercury Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000187:drug effects*
D010663:Phenylmercury Compounds; D003577:Cytochrome P-450 Enzyme System; D010662:Phenylmercuric Acetate; C008860:phenylmercuric nitrate, basic
Zur Wirkung von Phenylquecksilberacetat und Nitrat bei kombinierter Verabreichung an Ratten: Schilddrüse, Enzyme der Leber, morphologische Befunde an Gehirn und Nieren.