Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor alpha-subunit.
We have isolated a complementary DNA clone containing sequences homologous to those encoding the alpha-subunit of a mouse muscle nicotinic acetylcholine receptor. Based on the structural similarities between the encoded protein and the muscle acetylcholine receptor alpha-subunit, and the presence of hybridizing RNA species in the brain, we propose that this clone codes for a neural nicotinic acetylcholine receptor alpha-subunit.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000502:physiology; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005796:Genes; D046911:Macromolecular Substances; D051379:Mice; D009693:Nucleic Acid Hybridization; D010673:Pheochromocytoma; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011978:Receptors, Nicotinic / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D046911:Macromolecular Substances; D012333:RNA, Messenger; D011978:Receptors, Nicotinic; D004247:DNA