The effect of nifedipine on exercise-induced asthma.
This article describes the effect of nifedipine, a calcium antagonist, on exercise-induced asthma (EIA). Effect of sublingual administration of 20 mg of nifedipine or placebo was studied in randomized double-blind manner on separate days in 19 extrinsic asthmatic subjects. Nifedipine was found to be significantly effective in abolishing the exercise-induced decrease in forced vital capacity (FVC) and maximal expiratory flows (p less than 0.001). There were no significant changes in heart rate and blood pressure after nifedipine.
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use*; D011897:Random Allocation
D009543:Nifedipine