Autoradiographic analysis of D-[3H]aspartate binding in human basal ganglia.
The binding of D-[3H]aspartate to sections of human basal ganglia was measured autoradiographically. Highest binding was observed in the cerebral cortex, nucleus accumbens, caudate nucleus and putamen. The level of binding in the globus pallidus was low. D-[3H]Aspartate binding had a similar distribution to the high-affinity [3H]glutamate uptake sites and may be a useful marker for glutamate-aspartate terminals in human brain.
D000368:Aged; D001224:Aspartic Acid / Q000378:metabolism*; D001345:Autoradiography; D001479:Basal Ganglia / Q000378:metabolism*; D001665:Binding Sites; D006801:Humans
D001224:Aspartic Acid