title: Contralateral corticorubral fibers induced by neonatal lesions are not collaterals of the normal ipsilateral projection.
abstract: Unilateral neonatal cortical ablation induces the development of a bilateral corticorubral projection from the remaining sensorimotor cortex. The retrograde fluorescent tracers Fast blue (FB) and Nuclear yellow (NY) were used to determine if the aberrant contralateral projection arises from axon collaterals of the normal uncrossed projection. Six to 8 weeks after unilateral cortical ablation in neonatal rats, the red nuclei were injected with FB on one side and NY on the other to study the source of the normal and aberrant afferents from the cerebral cortex. In control animals, many neurons in layer V of the sensorimotor cortex were retrogradely labeled with the tracer that had been injected into the ipsilateral red nucleus. In animals with unilateral ablations, many neurons throughout the remaining sensorimotor cortex were retrogradely labeled with FB or NY. No cortical neurons were doubly labeled. In addition to demonstrating the bilaterality of the corticorubral projection in animals which had received neonatal lesions, these results indicate that the aberrant contralateral corticorubral projection does not consist of axon collaterals of the normal ipsilateral fibers.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004525:Efferent Pathways / Q000473:pathology; D009044:Motor Cortex / Q000293:injuries*; D051381:Rats; D012012:Red Nucleus / Q000473:pathology*; D013003:Somatosensory Cortex / Q000293:injuries*