Kinetics of methaemoglobin production. (2). Kinetics of the cyanide antidote p-aminopropiophenone during oral administration.
The kinetics of methaemoglobin production by orally administered p-aminopropiophenone (PAPP) was studied by using a kinetic model previously developed to describe methaemoglobinaemia consequent on intravenous injection of PAPP. Both ISIS, a simulation package, and NONLIN, a non-linear least-squares regression analysis program, were used to analyse the data. Some modification of the model was necessary to describe oral profiles and 40-50% of the administered PAPP appeared to be being metabolized at first pass to a non-active metabolite.
D000284:Administration, Oral; D000818:Animals; D003198:Computer Simulation; D003486:Cyanides / Q000037:antagonists & inhibitors* / Q000506:poisoning; D004285:Dogs; D005260:Female; D007700:Kinetics; D008706:Methemoglobin / Q000096:biosynthesis*; D008708:Methemoglobinemia / Q000139:chemically induced; D008954:Models, Biological; D011427:Propiophenones / Q000008:administration & dosage / Q000494:pharmacology*
D003486:Cyanides; D011427:Propiophenones; C029564:4-aminopropiophenone; D008706:Methemoglobin