title: Efficacy of clorsulon against mature, naturally acquired Fasciola hepatica infections in cattle and sheep.
abstract: Clorsulon (3.5 or 7 mg/kg of body weight) was given orally to mature cows (dairy or beef) and to mature mixed-breed sheep harboring patent infections of Fasciola hepatica. Eighteen animals of each species were assigned to a control group (drug vehicle) or to 1 of 2 treatment (3.5 or 7.0 mg/kg) groups of 6 animals each. On posttreatment days 8 (cows) or 14 (sheep), the animals were slaughtered for recovery of flukes. In cows, the efficacy (P values for treatment groups vs control) of clorsulon against infections of mature F hepatica was 99.21% (P less than or equal to 0.0065) at 3.5 mg/kg and was 100% (P less than or equal to 0.0039) at 7 mg/kg. In sheep, the efficacy was 93.33% (P less than or equal to 0.0104) at 3.5 mg/kg and was 100% (P less than or equal to 0.0039) at 7 mg/kg. These results indicate that clorsulon is a highly effective compound for the treatment of mature F hepatica in cows and sheep.
mesh_terms: D000818:Animals; D000980:Antiplatyhelmintic Agents / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005210:Fasciola hepatica / Q000302:isolation & purification; D005211:Fascioliasis / Q000188:drug therapy / Q000662:veterinary*; D005243:Feces; D005260:Female; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D013424:Sulfanilamides / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000980:Antiplatyhelmintic Agents; D013424:Sulfanilamides; C015675:clorsulon