[Free serum amino acids for monitoring the therapy of female patients with breast cancer].
A continuous monitoring by chromatographic determination of 10 free serum amino acids was carried out in 21 breast cancer patients. The results show, that the pretherapeutic levels of asparagine, glutamine, alanine, isoleucine, leucine, tyrosine and phenylalanine are significantly elevated if the disease progressed within the next two years. Asparagine, glutamine, glycine, alanine, tyrosine and phenylalanine are significantly elevated if no progression could be observed. In patients without progression the level of free serum amino acid went back to normal during one year. The determination of free serum amino acid is qualified for monitoring the treatment results in breast cancer patients.
D000596:Amino Acids / Q000097:blood*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D011379:Prognosis
D000596:Amino Acids; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
Freie Serumaminosäuren im Therapiemonitoring bei Patientinnen mit einem Mammakarzinom.