title: Altered pattern evoked retinal and cortical potentials associated with human senescence.
abstract: Physiologically healthy elderly individuals often exhibit visual deficits which result from age-related changes in both the transmission characteristics of the ocular media and the functional properties of the neural elements in the visual pathway. Many of the age-related changes in the optical quality of the ocular media have been identified, but the age-dependent variations in visual neurophysiology have not been clearly delineated. This investigation examined age-related alterations in pattern-specific biopotentials generated in the human retina and visual cortex. Counterphasing (2.0 and 7.5 rps) patterns (7.5', 15', 30' and 60' checks) were used to simultaneously monitor pattern-reversal visual evoked potentials (PRVEPs). Young visual normals (20-30 years of age) and healthy elderly observers (70-80 years of age) with visual acuity of 20/30 or better were studied. All data were corrected for the effects of senile miosis on retinal illumination. Significant variations in the waveform characteristics of both biopotentials were noted for the elderly individuals. PRRP amplitude was uniformly reduced for all stimulus conditions. PRVEP amplitude reductions were also noted but were more stimulus specific than the PRRP amplitude reductions. No significant PRVEP or PRRP latency changes were observed. These results suggest that alterations in the physiological properties of neural elements in both the retina and visual cortex are associated with normal aging.
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D004586:Electrophoresis; D005074:Evoked Potentials, Visual; D006801:Humans; D012160:Retina / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*