title: Effects of desipramine and chlorimipramine on buprenorphine analgesia in mice.
abstract: The effects of the tricyclic antidepressants desipramine HCI and chlorimipramine HCI on buprenorphine HCI antinociceptive activity were studied in mice using the hot-plate and the tail-flick methods. In the hot-plate test, desipramine caused a transient antinociceptive effect at low doses, but it decreased buprenorphine analgesia. Chlorimipramine in this test caused a more sustained antinociceptive effect, especially at relatively higher doses, and it did not significantly change buprenorphine analgesia. In the tail-flick test, desipramine either reduced or increased the tail-flick latency in a dose-specific manner, and chlorimipramine (10 mg/kg) significantly increased the tail-flick latency. Desipramine (1 mg/kg) caused a decrease followed by an increase in buprenorphine analgesia. Desipramine (5 and 10 mg/kg) caused significant increases in buprenorphine analgesia. All doses of chlorimipramine (1, 5 and 10 mg/kg) caused significant increases in buprenorphine analgesia. Thus, depending on the test employed, buprenorphine analgesia was modified differently by these tricyclics. Biochemical data suggested a greater role for brain 5-hydroxytryptamine (5-HT) than noradrenaline in tricyclic analgesia.
mesh_terms: D000700:Analgesics; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002047:Buprenorphine / Q000494:pharmacology*; D002997:Clomipramine / Q000494:pharmacology*; D003891:Desipramine / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D051379:Mice; D009019:Morphinans / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D013116:Spinal Cord / Q000378:metabolism
chemical_list: D000700:Analgesics; D001679:Biogenic Amines; D009019:Morphinans; D002047:Buprenorphine; D002997:Clomipramine; D003891:Desipramine