Promotion by sodium bromide of functional synapse formation from foreign nerves in the superior cervical ganglion of adult rat with intact preganglionic nerve supply.
The possible effect of sodium bromide (NaBr) (a substance with known inhibitory action on synaptic transmission) was studied on synapse formation with foreign nerves, implanted into the superior cervical ganglion of adult rats. It was found that in spite of the presence of preganglionic nerve supply, both implanted nerves (n.XII and n.X, respectively) were enabled to establish functional synapses with the principal ganglion cells in NaBr-treated animals. In contrast, synapse formation was almost absent in ganglia of sodium chloride drinking (control) rats with intact preganglionic nerve supply. This effect of NaBr is considered to be analogous to that of GABA, whose promoting action on synaptogenesis in adult rat superior cervical ganglion has been previously described.
D000818:Animals; D001965:Bromides / Q000494:pharmacology*; D005728:Ganglia, Sympathetic / Q000187:drug effects*; D007002:Hypoglossal Nerve / Q000187:drug effects*; D051381:Rats; D012964:Sodium / Q000494:pharmacology*; D017670:Sodium Compounds; D013268:Stimulation, Chemical; D013569:Synapses / Q000187:drug effects*; D014630:Vagus Nerve / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D001965:Bromides; D017670:Sodium Compounds; D005680:gamma-Aminobutyric Acid; D012964:Sodium; C027938:sodium bromide