Plasmacytoma and follicular lymphoma in a case of Hashimoto's thyroiditis.
Monoclonal gammopathy (IgG, lambda) in a 37-year-old man with Hashimoto's thyroiditis, was markedly decreased after thyroidectomy. Histological examination of the thyroid showed large lymphoid follicles surrounded by a massive proliferation of plasma cells. Immunological studies revealed that interfollicular plasma cells stained monotypically for lambda chain, findings in keeping with a diagnosis of plasmacytoma of the thyroid. In addition, there was kappa monotypic staining of the lymphoid follicles and absence of tangible body macrophages, indicating the presence of a follicular lymphoma derived from a separate cell line from the plasmacytoma.
D000328:Adult; D000911:Antibodies, Monoclonal; D006801:Humans; D008223:Lymphoma / Q000150:complications / Q000276:immunology / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010954:Plasmacytoma / Q000150:complications / Q000276:immunology / Q000473:pathology*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013964:Thyroid Neoplasms / Q000150:complications / Q000276:immunology / Q000473:pathology*; D013965:Thyroidectomy; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000276:immunology / Q000473:pathology*
D000911:Antibodies, Monoclonal; D011947:Receptors, Antigen, B-Cell