title: Carcinoma in situ of the vulva. A clinicopathologic study of 50 cases.
abstract: The authors reviewed 50 cases of carcinoma in situ of the vulva treated at the University of Texas Medical Branch, Galveston, from 1975 to 1984. Sixty-two percent of the patients were premenopausal. The most frequent complaint was vulvar itching. Twenty-six percent of the patients were asymptomatic. Recurrences were frequent (25%) and were associated with multifocal lesions, involved surgical margins and the bowenoid histologic type. Superficially invasive carcinoma was detected in 8% of patients, mostly postmenopausal women with simplex histologic types. Immunohistochemical studies failed to detect papillomavirus- or herpesvirus-associated antigens in any of the cases. Follow-up of 48 patients from six months to ten years revealed no mortality from invasive cancer.
mesh_terms: D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000150:complications; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D012008:Recurrence; D012749:Sexually Transmitted Diseases / Q000150:complications; D014846:Vulvar Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery