Passive immunization of hamsters against experimental infection with the Lyme disease spirochete.
Hamsters passively immunized with as little as 0.0125 ml of immune rabbit serum (indirect fluorescent-antibody titer, 1:8,192) were protected from challenge with 1,000 50% infective doses of Borrelia burgdorferi. Cross-protection studies with Minnesota and Connecticut isolates of B. burgdorferi indicated no major differences in their capacity to elicit mutually protective antibodies in rabbits.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001898:Borrelia / Q000276:immunology*; D025065:Borrelia burgdorferi; D006224:Cricetinae; D005260:Female; D007116:Immunization, Passive; D008193:Lyme Disease / Q000276:immunology*; D008297:Male; D011817:Rabbits
D000907:Antibodies, Bacterial