title: [Mechanism of the change in erythrocyte osmotic resistance in rats exposed to valinomycin: the features seen in spontaneous hypertension].
abstract: Introduction of valinomycin into erythrocyte incubation medium increased the cell stability to water-induced hemolysis. In these conditions the erythrocytes of spontaneously hypertensive and normotensive (control) rats release 63.2 +/- 1.5% and 80.9 +/- 1.6%, respectively, of the total hemoglobin content. Valinomycin effect is completely abolished with K+ substitution for Na+ and is independent of extracellular Ca2+ concentration. Valinomycin had no effect on human erythrocyte osmotic stability. It has been shown that valinomycin-induced kinetics of Na+ and K+ redistribution was different in human and rat erythrocytes. The distinctions are thought to be related to specific anion transport mediated by the third band protein--the main component of membrane cytoskeleton.
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood; D006973:Hypertension / Q000097:blood*; D007700:Kinetics; D008297:Male; D009996:Osmotic Fragility / Q000187:drug effects*; D011188:Potassium / Q000097:blood; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012964:Sodium / Q000097:blood; D014634:Valinomycin / Q000494:pharmacology*
chemical_list: D014634:Valinomycin; D012964:Sodium; D011188:Potassium; D002118:Calcium
vernacular_title: O mekhanizme izmeneniia osmoticheskoĭ ustoĭchivosti éritrotsitov krysy pri deĭstvii valinomitsina: osobennosti, vyiavliaemye pri spontannoĭ gipertenzii.