title: [Results of combined treatment (by surgery, ionizing radiation and the cytostatic drug CCNU) of patients with anaplastic glial neoplasms of the brain].
abstract: For estimating the effectiveness of combined treatment of cases of anaplastic gliomas of the cerebral hemispheres retrospective analysis was undertaken of 83 patients treated only surgically and prospective analysis of 81 patients treated by the combined method. In the group treated only surgically 47 patients had glioblastoma multiforme, and 36 had anaplastic oligodendroglioma. The general condition and the neurological status were evaluated using the score of Karnofsky. In the group of combined treatment the patients were given telegammatherapy from Co-60 cobalt source by the method of Skołyszewski and CCNU (Belustine) every 6-8 weeks for 1 year in doses of 100 mg/m2. In about 25% of patients transient leucopenia was observed, and 20% had transient thrombocytopenia. In about 30% of cases transient increase of intracranial pressure occurred. In the compared groups it was possible to establish, using the statistical method of representation probability of Kaplan-Meier and statistical analysis of Gehan as modified by Wilcoxon, that the mean survival time in the surgically treated patients was 6.25 months, while in the patients treated by combined method it was 13.97 months.
mesh_terms: D001921:Brain / Q000601:surgery; D001932:Brain Neoplasms / Q000401:mortality / Q000628:therapy*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005910:Glioma / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008130:Lomustine / Q000627:therapeutic use
chemical_list: D003037:Cobalt Radioisotopes; D008130:Lomustine
vernacular_title: Wyniki skojarzonego leczenia (operacyjnego, promieniami jonizujacymi i cytostatykiem CCNU) chorych z anaplastycznymi glejopochodnymi nowotworami mózgu.