title: Calcium action potentials in cultured adrenocortical cells.
abstract: Membrane potential has been recorded in Y-1 adrenocortical cells with intracellular microelectrodes. Resting potential averaged -68 +/- 13 mV (n = 63). Cells were silent at rest but depolarization by current pulses evoked repetitive action potentials of 80-120 mV amplitude and variable duration (between 10-300 ms). Action potentials were unaffected by removal of external Na or addition of TTX, however they were completely abolished by substitution of external Ca by Co. In Ca-free solutions with 2.4 mM Ba, action potentials had a lower threshold and lasted for the whole duration of the current pulse.
mesh_terms: D000200:Action Potentials; D000302:Adrenal Cortex / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000502:physiology*; D002478:Cells, Cultured; D005071:Evoked Potentials; D008564:Membrane Potentials; D051379:Mice
chemical_list: D002118:Calcium