Enhancement of fluoride retention by low dietary chloride without manifestation of chloride deficiency in the rat.
Weanling male albino rats were fed a purified diet containing 10 ppm fluoride as sodium fluoride and 0.02, 0.04, 0.06, 0.08, or 0.10% chloride as sodium chloride for 6 wk. Food intake was unaffected by the level of dietary chloride. Rats fed diets containing either 0.02 or 0.04% chloride had significantly higher fluoride retention and skeletal uptake of fluoride than did rats fed higher chloride levels. Diets, however, had to contain 0.04% chloride or more to support normal weight gain, femur ash weight and plasma chloride concentration. The ability to enhance fluoride content of bone on a low chloride diet without undesirable effects of chloride deficiency may have important implications, since fluoride is thought to play a role in strengthening the mineral apatite structure of bone.
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001682:Biological Availability; D001842:Bone and Bones / Q000378:metabolism*; D002712:Chlorides / Q000172:deficiency*; D004039:Diet, Sodium-Restricted; D005459:Fluorides / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000008:administration & dosage
D002712:Chlorides; D012965:Sodium Chloride; D005459:Fluorides