title: Metabolic consequences of forced diuresis following prostatectomy.
abstract: The efficacy and metabolic consequences of a standardised forced diuresis regime following prostatectomy were studied in three parts. A retrospective review of 372 patients. A detailed prospective study of blood and urine electrolyte changes in 25 patients. A prospective study of urinary oxalate levels in 15 patients. The regime was effective in safely preventing post-operative clot retention. In 54% of patients the plasma sodium fell below 135 mmol/l. Hypokalaemia was mild and transient except in patients on long-term diuretics. There was a significant per-operative fall in serum calcium levels. It was concluded that forced diuresis is a safe and effective method of reducing clot retention following prostatectomy. The high incidence of post-operative hyponatraemia suggests that absorption of glycine solution at transurethral prostatectomy is a common occurrence.
mesh_terms: D003404:Creatinine / Q000378:metabolism; D004231:Diuresis; D004573:Electrolytes / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D010070:Oxalates / Q000652:urine; D019815:Oxalic Acid; D011446:Prospective Studies; D011468:Prostatectomy / Q000009:adverse effects; D012189:Retrospective Studies; D012964:Sodium / Q000378:metabolism
chemical_list: D004573:Electrolytes; D010070:Oxalates; D019815:Oxalic Acid; D012964:Sodium; D003404:Creatinine; D006854:Hydrocortisone