Specificity of CSF antibodies against components of Borrelia burgdorferi in patients with meningopolyneuritis Garin-Bujadoux-Bannwarth.
The specificity of immunoglobulin (Ig) for components of Borrelia burgdorferi was investigated in cerebrospinal fluid (CSF), serum and in CSF oligoclonal bands from nine patients with meningopolyneuritis Garin-Bujadoux-Bannwarth (MPN-GBB). All patients showed specific IgG and IgM antibodies in serum and CSF when incubated with a lysate of B. burgdorferi strain B 31. Specific antibody was detected in CSF but not in paired serum samples, indicating intrathecal synthesis. Investigation of the specificity of oligoclonal Ig in the CSF revealed oligoclonal bands with specificity for B. burgdorferi in one of the nine patients.
D000917:Antibody Formation; D000918:Antibody Specificity; D001898:Borrelia / Q000276:immunology; D001899:Borrelia Infections / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid*; D007525:Isoelectric Focusing; D008581:Meningitis / Q000276:immunology*; D043025:Oligoclonal Bands; D011115:Polyneuropathies / Q000276:immunology*
D007136:Immunoglobulins; D043025:Oligoclonal Bands