Alignment of cilia in immotile-cilia syndrome.
Alignment of cilia in nasal epithelial cells from eight human subjects suffering from immotile-cilia syndrome was compared with that of cells from five control subjects. Individual cilia were assessed according to the orientation of their basal feet. The range of orientation of basal feet on a single cell varied from 26 degrees to 261 degrees and 54 degrees to 275 degrees in controls and patients respectively. Less than 10% of the cells from each group supported cilia that were aligned randomly. Alignment was worse in subjects with immotile-cilia syndrome but this could well have been due to secondary characteristics of the disease, such as common viral infection. Very accurate alignment of mucus-propelling cilia may be unnecessary. Measurements from control subjects and some invertebrates suggest that ranges of 140 degrees are common and do not seriously impair mucus propulsion.
D002923:Cilia / Q000648:ultrastructure*; D002925:Ciliary Motility Disorders / Q000473:pathology*; D004848:Epithelium / Q000648:ultrastructure; D006801:Humans; D009297:Nasal Mucosa / Q000648:ultrastructure*; D012907:Smoking