The kidney invasion test: its application to the Lewis lung carcinoma system.
Implantation of fragments from subcutaneously grown Lewis lung carcinoma 3LL under the renal capsule of syngeneic mice results in invasion of the kidney parenchyma. The synthetic microtubule inhibitor tubulozole blocks or decreases this malignant invasion in a dose-dependent manner. The inhibition of the invasion rate caused by tubulozole can be macroscopically quantified, and has been confirmed histologically.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004148:Dioxolanes / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology*; D007668:Kidney / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D051379:Mice; D009361:Neoplasm Invasiveness
D000970:Antineoplastic Agents; D004148:Dioxolanes; D004149:Dioxoles; C040422:tubulazole