Characterization of a Pasteurella multocida (serotype B) bovine pneumonic pasteurellosis model and the effect of antimicrobials during peracute infection.
A method to produce bovine pneumonic pasteurellosis for experimental purposes was studied and the clinical response of experimentally infected calves to selected antimicrobials was characterized. Male Holstein calves stressed with multiple hot and cold water applications followed by intratracheal inoculation of broth cultures of Pasteurella multocida serotype B developed acute clinical illness consistent with pneumonia. Infected, untreated calves consistently developed classic pneumonic pasteurellosis, infected calves treated with either oxytetracycline or sulfadimethoxine recovered from acute clinical disease, and the uninfected controls remained healthy. This disease model offers potential for use in pharmacokinetic and target tissue drug concentration studies and for dosage titration of drugs intended for treatment of bacterial pneumonias.
D000208:Acute Disease; D000818:Animals; D000831:Animals, Newborn; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D010118:Oxytetracycline / Q000627:therapeutic use*; D010326:Pasteurella Infections / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011014:Pneumonia / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D013412:Sulfadimethoxine / Q000627:therapeutic use*
D013412:Sulfadimethoxine; D010118:Oxytetracycline