Assessment of the ability of mice fed on vitamin A supplemented diet to respond to a variety of potential contact sensitizers.
The contact sensitizing potential of various compounds was tested in mice maintained on a diet supplemented with vitamin A acetate. Substances were applied epicutaneously. After challenge, increases in ear thickness were measured and the differences in response between control and treated groups determined by the Mann Whitney test. A number of sensitizers, including Dowicil 200, cinnamaldehyde, hydroxycitronellal and Kathon CG gave positive sensitivity responses.
D000485:Allergens; D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology*; D004224:Diterpenes; D004357:Drug Synergism; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D004364:Pharmaceutical Preparations / Q000276:immunology; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology
D000485:Allergens; D004224:Diterpenes; D004364:Pharmaceutical Preparations; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate