Binding of oestradiol to blood proteins and aetiology of breast cancer.
A prospective study of 5,000 women has shown that, compared to controls, those who subsequently developed breast cancer had a higher proportion of their blood oestradiol in the non-protein-bound and albumin-bound fractions (the bio-available fraction) and a lower proportion in the sex-hormone-bound fraction. The increased proportion of bio-available oestradiol was partly due to a lower concentration of sex-hormone-binding globulin. Weight was excluded as a confounding factor.
D000328:Adult; D001682:Biological Availability; D001798:Blood Proteins / Q000378:metabolism*; D001835:Body Weight; D001943:Breast Neoplasms / Q000209:etiology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D011446:Prospective Studies; D012709:Serum Albumin / Q000032:analysis; D012738:Sex Hormone-Binding Globulin / Q000032:analysis
D001798:Blood Proteins; D012709:Serum Albumin; D012738:Sex Hormone-Binding Globulin; D004958:Estradiol