Analysis of free growth and post-treatment regrowth of C3H mammary carcinoma in individual mice.
Free growth and post-Doxorubicin treatment regrowth of the C3H mammary carcinoma were analysed in individual mice. In both cases, the Gompertzian function provided a better fit than the exponential function, and the difference was statistically significant (P less than 0.001, chi 2 test). No comprehensive Gompertzian function was found, and each individual tumour growth or regrowth was described by a specific curve. Nevertheless, although both individually measured alpha 0 and beta, Gompertzian parameters varied from one animal to another, in both free-growing and post-treatment regrowing tumours a strong linear correlation between alpha 0 and beta was found. A parallelism test was performed to verify if there exists any treatment-induced alteration. The two regression lines appeared to be identical, however.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D008433:Mathematics; D051379:Mice; D008809:Mice, Inbred C3H; D008954:Models, Biological
D004317:Doxorubicin