Cell membrane transport enzymes in cultured dermal fibroblasts from progeroid donors: a comparison to other human fibroblasts.
Cell membranes from progeroid fibroblasts had an elevated Na+, K+ ATPase. Ca++ ATPase and gamma-glutamyl transpeptidase were markedly decreased in progeroid fibroblast membranes. 5'-nucleotide phosphatase was unchanged, compared to age- and sex-matched normal fibroblast membranes. Fetal lung fibroblasts and dermal fibroblast from myotonic dystrophy victims had enzyme activities similar to those of the normal dermal fibroblasts.
D000293:Adolescent; D001692:Biological Transport; D002462:Cell Membrane / Q000201:enzymology; D002478:Cells, Cultured; D002648:Child; D005347:Fibroblasts / Q000201:enzymology / Q000648:ultrastructure; D006801:Humans; D008297:Male; D011371:Progeria / Q000378:metabolism* / Q000473:pathology; D012867:Skin / Q000201:enzymology* / Q000648:ultrastructure