In vivo skeletal localization properties of 99mTc complexes of large phosphonate ligands.
Tetramethylenephosphonate derivatives of norborane (TPNB) and dicyclopentadiene (TPDCPD) were shown to readily form stable chelates with 99mTc that had high and selective bone uptake. The skeletal uptake and blood clearance properties of 99mTc-TPNB were similar to 99mTc-MDP in both rats and rabbits. This suggests additional studies to further evaluate 99mTc-TPNB or perhaps other large-organic based multidentate phosphonate ligands as potential bone imaging agents is warranted.
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D003517:Cyclopentanes / Q000138:chemical synthesis; D007202:Indicators and Reagents; D007700:Kinetics; D008099:Liver / Q000000981:diagnostic imaging; D008297:Male; D009636:Norbornanes / Q000138:chemical synthesis; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013667:Technetium / Q000138:chemical synthesis / Q000378:metabolism; D014018:Tissue Distribution
D003517:Cyclopentanes; D007202:Indicators and Reagents; D009636:Norbornanes; D015609:Organotechnetium Compounds; C050515:technetium Tc 99m dicyclopentadienetetramethylenephosphonate; C050514:technetium Tc 99m norbornanetetramethylenephosphonate; D013667:Technetium