The bioavailability of Tamoplex (tamoxifen). Part 1. A pilot study.
Tamoxifen and N-desmethyltamoxifen plasma concentrations were found to be similar after a first single dose and during two months therapy with Tamoplex or Nolvadex in groups of 6 and 8 patients, respectively. Single dose absorption results in 10 healthy male volunteers demonstrated bioequivalence of Tamoplex and Nolvadex 10 mg tablets. A large interindividual variation in tamoxifen absorption data was observed, probably related to the dominating metabolic clearance of tamoxifen.
D000328:Adult; D000368:Aged; D001682:Biological Availability; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D013629:Tamoxifen / Q000031:analogs & derivatives / Q000378:metabolism*
D013629:Tamoxifen; C028787:N-desmethyltamoxifen