title: Activity of ivermectin against natural infections by abomasal nematodes in lambs in controlled tests: evaluation of equine and bovine injectable formulations administered intraorally.
abstract: The efficacy of 2 injectable formulations of ivermectin, administered intraorally at the dosage of 200 micrograms/kg of body weight, was evaluated against naturally occurring infections by abomasal nematodes in lambs in 2 controlled tests. One test (A) included 17 lambs treated with the equine formulation and 16 nontreated lambs. For the other test (B), 14 lambs were treated with the bovine formulation, and 12 were nontreated. In controlled test A, only mature nematodes were recovered, and removals were 98% to 100% for Haemonchus contortus, Ostertagia circumcincta male, O trifurcata male, Ostertagia spp female, and Trichostrongylus axei. For controlled test B, removals were 99% to 100% for Haemonchus spp (immature), H contortus (mature), Ostertagia spp (immature), O circumcincta male (mature), O trifurcata male (mature), Ostertagia spp female (mature), Trichostrongylus spp (immature), and T axei (mature). Toxicosis was not evident in treated lambs.
mesh_terms: D000018:Abomasum / Q000469:parasitology*; D000284:Administration, Oral; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007559:Ivermectin; D007783:Lactones / Q000008:administration & dosage / Q000627:therapeutic use*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology; D014252:Trichostrongyloidiasis / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000969:Antinematodal Agents; D007783:Lactones; D007559:Ivermectin