title: Fish and antibiotics: pharmacokinetics of sulphadimidine in carp (Cyprinus carpio).
abstract: Pharmacokinetics, metabolism and clearance of sulphadimidine (SDM) were studied after a single intraperitoneal injection of SDM in carp at 20 degrees C. SDM was acetylated and hydroxylated to a small extent. The main metabolite was N4-acetyl derivative amounting only 2% of the total drug dose excreted; hydroxylation was less important (0.41% of the dose). The elimination half-life for SDM in carp was 17.5 h. The clearance values for SDM and its metabolites were equivalent. The importance of pharmacokinetic studies in different fish species is discussed.
mesh_terms: D000818:Animals; D002347:Carps / Q000378:metabolism*; D003530:Cyprinidae / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007700:Kinetics; D013418:Sulfamethazine / Q000097:blood / Q000378:metabolism*
chemical_list: D013418:Sulfamethazine