Changes of adrenal vasopressin during hemorrhagic shock in rats with hereditary diabetes insipidus (Brattleboro strain).
The adrenal gland of the Brattleboro rat contains AVP-like immunoassayable material in amounts equal to those of the normal Long Evans animal--6.180 ng/g fresh tissue in LE and 6.108 ng/g fresh tissue in the Brattleboro rats. After an activation of sympathetic NS and vasopressin secretion by hemorrhagic shock, the adrenal AVP-like material in LE increased by 54% and in Brattleboro rats--by 58%. After hemorrhagic shock plasma AVP in LE rats increased 3.5 fold, but in Brattleboro rats remained undetectable. The possible physiological role of adrenal AVP was discussed.
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D002850:Chromatography, Gel; D003919:Diabetes Insipidus / Q000150:complications / Q000378:metabolism*; D008297:Male; D051381:Rats; D011910:Rats, Brattleboro; D012771:Shock, Hemorrhagic / Q000150:complications / Q000378:metabolism*; D014667:Vasopressins / Q000378:metabolism*
D014667:Vasopressins