[Effectiveness of lipid peroxidation inhibition in biomembranes by antioxidants with and without hydrocarbon chains].
The efficacy of lipid peroxidation inhibition by the natural antioxidant alpha-tocopherol and 2,2,5,7,8-pentamethyl-6-hydroxy-chromane (PMC), a derivative without hydrocarbon tail, as well as by the synthetic antioxidant 4-methyl-2,6-diterbutyl phenol (BHT) and its phospholipid derivative was studied in the membranes of rat liver microsomes and mitochondria. The presence of hydrocarbon tail in the antioxidant molecule determines the decrease of antioxidant efficiency in biomembranes. PMC and BHT exert a destructive effect on biomembranes, leading to an increase in their permeability to ions. This evidence suggests that the presence of hydrocarbon tail in the molecules of natural antioxidants provides not only for a relatively high antioxidant efficiency but also for a structural stability of biomembranes.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002839:Chromans / Q000494:pharmacology; D003864:Depression, Chemical; D007425:Intracellular Membranes / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D002839:Chromans; D008054:Lipid Peroxides; D014810:Vitamin E; D002084:Butylated Hydroxytoluene; C029141:2,2,5,7,8-pentamethyl-1-hydroxychroman
Effektivnost' ingibirovaniia perekisnogo okisleniia lipidov v biomembranakh antioksidantami, soderzhashchimi i ne soderzhashchimi uglevodorodnye tsepi.