[Toxicity studies of VP 16-213 (VI)--Antigenicity in guinea pigs].
VP 16-213 (etoposide, abbr. to VP), an oncostatic drug, and VP-protein conjugates were examined for their antigenic properties using male Hartley guinea pigs. The results of systemic anaphylaxis test, passive cutaneous anaphylaxis test, passive hemagglutination test and Schultz-Dale reaction revealed that VP possessed neither antigenic nor haptenic properties. The dose levels of VP employed in the present experiment were confirmed not to suppress immune reactions.
D000818:Animals; D005047:Etoposide / Q000276:immunology* / Q000378:metabolism / Q000494:pharmacology; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D007166:Immunosuppressive Agents; D066298:In Vitro Techniques; D007428:Intradermal Tests; D008297:Male; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism
D007166:Immunosuppressive Agents; D012709:Serum Albumin; D005047:Etoposide