title: Oropharynx decontamination preventing Candida vegetation on voice prostheses.
abstract: Candida vegetations found in silicone voice prostheses used in postlaryngectomy voice rehabilitation are associated with prosthesis dysfunction. Selective oropharyngeal decontamination with amphotericin B lozenges resulted in sharp decrease of oropharyngeal Candida concentrations with a subsequent reduction of yeast colonization on voice prostheses and in tracheoesophageal fistula in ten patients. A case report suggests that this selective oropharyngeal decontamination can prolong the device's lifetime.
mesh_terms: D000284:Administration, Oral; D000666:Amphotericin B / Q000008:administration & dosage; D002175:Candida / Q000187:drug effects*; D003666:Decontamination / Q000379:methods*; D006801:Humans; D007831:Larynx, Artificial; D009960:Oropharynx / Q000382:microbiology*; D010865:Pilot Projects; D011446:Prospective Studies; D011475:Prosthesis Failure; D012828:Silicones
chemical_list: D012828:Silicones; D000666:Amphotericin B