Duodenal ulceration: a complication of tolazoline therapy.
Tolazoline Hydrochloride is a pulmonary vasodilator that is used for the treatment of pulmonary hypertension of the newborn. Two patients who were receiving Tolazoline by infusion developed duodenal ulceration and subsequent intestinal perforation. This undesirable side effect of Tolazoline may be prevented by the concomitant use of antacids to maintain gastric pH greater than 5.
D004381:Duodenal Ulcer / Q000139:chemically induced*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D007231:Infant, Newborn; D010439:Peptic Ulcer Perforation / Q000139:chemically induced*; D014043:Tolazoline / Q000009:adverse effects*
D014043:Tolazoline