Effects of human interferon-alpha on UV-induced DNA-repair synthesis and cell killing.
Cells of a human transformed cell line, RSb, which have unusually high sensitivity to UV killing and low DNA-repair capacity and which can be induced into antiviral states by human interferon (HuIFN)-alpha (Suzuki et al., 1982), acquired increased levels of DNA-repair synthesis and cell survival when pretreated with HuIFN-alpha before UV irradiation. The increased effects of HuIFN-alpha were also observed in other transformed VA13 cells and AK fibroblast cells.
D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects*; D004261:DNA Replication / Q000187:drug effects / Q000528:radiation effects*; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007700:Kinetics; D014466:Ultraviolet Rays
D007370:Interferon Type I