[Changes in the concentration of pilocarpine eyedrops in normal storage].
The accommodative myopia induced by pilocarpine eye drops served as an indicator for the pharmacological activity. In a case of pigment glaucoma a reproducible 50% decay of the accomodative myopia was measured in the course of two weeks after opening an original bottle. Correlated to the reduction in accommodative myopia, a rise in intraocular pressure was observed. This may be due to an active principle decay caused by moderate temperatures.
D000065:Accommodation, Ocular / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004356:Drug Storage; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000032:analysis* / Q000627:therapeutic use; D012029:Refraction, Ocular; D013696:Temperature
D009883:Ophthalmic Solutions; D010862:Pilocarpine
Veränderung der Konzentration von Pilokarpin-Augentropfen bei normaler Aufbewahrung.