title: [Functional state of the hypophysis and ovaries of rats with anovulatory syndrome during pharmacologic stimulation of dopaminergic receptors].
abstract: Pharmacological analysis of the role of hyperprolactinemia in the pathogenesis of anovulatory syndrome (AS) was performed in neonatally androgenized rats. Dopamine agonist, bromocriptine, administered to I or 2.5 month-old rats for 15 days decreased prolactin content in the adenohypophysis and partially normalized progesterone level in blood plasma. However, bromocriptine failed to prevent the development of AS or to interrupt persistent estrus in neonatally androgenized females. The results are in keeping with the concept on the leading role of hypothalamus noradrenergic insufficiency in the pathogenesis of experimental AS.
mesh_terms: D000818:Animals; D000858:Anovulation / Q000503:physiopathology*; D001971:Bromocriptine / Q000494:pharmacology; D005260:Female; D010053:Ovary / Q000503:physiopathology*; D010903:Pituitary Gland, Anterior / Q000503:physiopathology*; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology
chemical_list: D011954:Receptors, Dopamine; D001971:Bromocriptine; D011388:Prolactin
vernacular_title: Funktsional'noe sostoianie gipofiza i iaichnikov krys s anovuliatornymsindromom pri farmakologicheskoĭ stimuliatsii dofaminergicheskikh retseptorov.