title: [Effect of carsil and legalon in treating chronic liver diseases].
abstract: The clinical effect from the treatment of 48 patients with carsil and 24 patients with legalon is studied. The patients were subdivided into three groups in the base of the clinical, laboratory-chemical and instrumental examination: light hepatic lesions--hepatic steatosis, chronic persisting hepatitis (ChPH), post-hepatitis states, chronic active hepatitis (ChAN) and cirrhosis of the liver (CL). Both preparations were administered 3 three times, 2 tablets daily for 3 months. The results obtained revealed that the bioflavonoid preparation carsil did not much differ in its clinical effect from the preparation legalon. The preparations carsil and legalon had a good effect, but not with statistical significance, on the subjective symptoms--pain, sense of heaviness and upper dyspeptic syndrome in the patients studied. Both preparations had a good effect on the biochemical indices: thymol test, SGOT, gamma-globulins, immunoglobulin G, blood bilirubin. The three month administration of carsil and legalon did not essentially change the histological findings in liver. The preparations carsil and legalon are indicated in light and moderate hepatic affections--hepatic steatosis, ChPH, post-hepatitis states. No contraindications have been reported for the administration of those preparations even in advanced hepatic disorders where they could be included as "basis" therapy.
mesh_terms: D000328:Adult; D000368:Aged; D002031:Bulgaria; D002908:Chronic Disease; D004341:Drug Evaluation; D005234:Fatty Liver / Q000188:drug therapy; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use*; D005860:Germany, West; D006521:Hepatitis, Chronic / Q000188:drug therapy; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy; D008107:Liver Diseases / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012838:Silymarin / Q000627:therapeutic use*
chemical_list: D005419:Flavonoids; D012838:Silymarin
vernacular_title: Efekt na karsila i legalona pri lechenieto na khronichnite chernodrobni zaboliavaniia.