Atypical presentation and neuropathological studies in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency.
A 6 1/2-month-old male offspring of consanguineous Egyptian parents was first seen because of fever, somnolence, vomiting, right focal motor seizures, right hemiparesis, elevated transaminase levels, hyperammonemia, and acidosis. A computed tomographic scan of the head suggested swelling of the left cerebral hemisphere, and an electroencephalogram indicated left frontotemporal abnormalities, but brain biopsy demonstrated diffuse white matter spongiosis and gliosis. Subsequently, urine organic acid analysis and enzyme assays were diagnostic of 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency.
D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000150:complications / Q000473:pathology; D002478:Cells, Cultured; D002493:Central Nervous System Diseases / Q000201:enzymology / Q000209:etiology* / Q000473:pathology; D005347:Fibroblasts / Q000201:enzymology; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000201:enzymology; D008297:Male; D007652:Oxo-Acid-Lyases / Q000172:deficiency* / Q000235:genetics; D010375:Pedigree
D007652:Oxo-Acid-Lyases; C021410:3-hydroxy-3-methylglutaryl-coenzyme A lyase