Preparation and biodistribution of 99mTc chelate of strophanthidin--a cardiac aglycone.
Cardiac glycosides are well known to exert a specific and powerful effect on myocardial tissue, and there is a possibility that this class of compound with a 99mTc radiolabel may behave as a superior myocardial imaging agent in comparison to 201Tl which is at present used clinically. Because of the extreme chemical complexity of cardiac glycosides a simpler aglycone, strophanthidin was selected as the pilot compound for preliminary labelling and in vivo distribution studies. Strophanthidin was converted to 19-thiosemicarbazone which nicely accommodated 99mTc to produce a pure radiopharmaceutical of high specific activity. The distribution pattern in animal models was studied which is in accordance with the metabolic studies performed earlier with the ligand itself.
D000818:Animals; D007202:Indicators and Reagents; D007420:Intestine, Large / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism; D007700:Kinetics; D008657:Metabolic Clearance Rate; D015609:Organotechnetium Compounds; D013327:Strophanthidin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D013667:Technetium / Q000138:chemical synthesis* / Q000378:metabolism; D014018:Tissue Distribution
D007202:Indicators and Reagents; D015609:Organotechnetium Compounds; C050516:technetium Tc 99m strophanthidin thiosemicarbazone; D013327:Strophanthidin; D013667:Technetium