title: [The role of N-quinones in the regulation of glucose-6-phosphate metabolism].
abstract: In experimental (white rats, rabbits) and clinical (erythrocytes, blood plasma) studies on 29 healthy subjects and patients it has been demonstrated that primary or secondary n-quinone deficiency is accompanied by increased tissue activity of glycolysis enzymes (aldolase, PGmutase) and aerobic pentose phosphate shunt (6 GPDH). Parallel rise in the amount of glycolysis metabolites (pyruvate and lactate) in the blood and the decline in blood plasma glucose level were observed. The changes in glucose-6-phosphate metabolism are, probably, secondary and reflect tissue structure alterations in the development of K and E avitaminosis.
mesh_terms: D000818:Animals; D019298:Glucose-6-Phosphate; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005958:Glucosephosphates / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D010084:Oxidation-Reduction; D010427:Pentose Phosphate Pathway; D011809:Quinones / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D014811:Vitamin E Deficiency / Q000378:metabolism; D014813:Vitamin K Deficiency / Q000378:metabolism
chemical_list: D005958:Glucosephosphates; D011809:Quinones; D019298:Glucose-6-Phosphate; D005954:Glucosephosphate Dehydrogenase
vernacular_title: Rol' N-khinonov v reguliatsii napravlennosti obmena gliukozo-6-fosfata.