Retardation of resynthesis of GABA-transaminase in some brain regions of amygdala-kindled rats.
The activities of GABA-transaminase (GABA-T) were examined in several brain regions of amygdala-kindled rats, pretreated either with or without gabaculine, an irreversible GABA-T inhibitor. Histochemical and biochemical studies demonstrated that GABA-T activities decreased significantly in some brain regions 16 h after the gabaculine treatment. In contrast, no such alteration was detected in kindled animals after a 48-h survival period either with or without the pharmacological manipulation. The present results suggest that kindling causes retardation of GABA-T resynthesis in neurons, since the GABA-T activities detected 16 h after the drug treatment are due to newly synthetized enzyme in presumptive GABA neurons but not glial cells.
D000612:4-Aminobutyrate Transaminase / Q000096:biosynthesis*; D000679:Amygdala / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000201:enzymology*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology; D004827:Epilepsy / Q000201:enzymology / Q000503:physiopathology; D006651:Histocytochemistry; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D009474:Neurons / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D003509:Cyclohexanecarboxylic Acids; C012987:gabaculine; D000612:4-Aminobutyrate Transaminase