Chlorimipramine--but not imipramine--rapidly reduces [3H]imipramine binding in human platelet membranes.
A single dose of 50 mg chlorimipramine was followed by a rapid and pronounced decrease in [3H]imipramine binding to platelet membranes. Incubation of human platelets or platelet membranes with 25 nM chlorimipramine similarly reduced [3H]imipramine binding. Imipramine, desmethylchlorimipramine, chlorpromazine and some serotonin uptake inhibitors did not have this effect. The effect was not due to chlorimipramine remaining in the membranes during the binding analysis.
D000639:Amitriptyline / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D002997:Clomipramine / Q000494:pharmacology*; D003866:Depressive Disorder / Q000097:blood; D006801:Humans; D007099:Imipramine / Q000378:metabolism / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics
D000639:Amitriptyline; D002997:Clomipramine; D007099:Imipramine