[Effect of a new structural analog of gamma-butyrobetaine-- 3-(2,2,2-trimethylhydrazine)propionate (THP) on carnitine level, carnitine-dependent fatty acid oxidation and various indices of energy metabolism in the myocardium].
Contents of carnitine and long chain acylcarnitine were decreased as well as oxidation of I-14C-palmitate was inhibited in rat myocardium after intraperitoneal administration of 3-(2,2,2-trimethylhydrazine) propionate (THP) at doses of 50 and 150 mg/kg within 10 days into animals maintained at a diet enriched with fat. THP did not affect the ATP content, elevated during the fat-enriched diet, but decreased the lactate concentration in myocardium. After administration of D,L-carnitine oxidation of I-14C-palmitate and content of lactate were increased with simultaneous decrease in ATP level. Combined administration of D,L-carnitine and THP did not affect the content of ATP and lactate as well as oxidation of fatty acids. The decrease in carnitine content caused by THP may be responsible for the alterations of energy metabolism in myocardium.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001622:Betaine / Q000031:analogs & derivatives / Q000494:pharmacology; D002331:Carnitine / Q000096:biosynthesis / Q000378:metabolism* / Q000494:pharmacology; D004041:Dietary Fats / Q000008:administration & dosage; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism; D008763:Methylhydrazines / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D010169:Palmitic Acids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D004041:Dietary Fats; D005227:Fatty Acids; D007773:Lactates; D008763:Methylhydrazines; D010169:Palmitic Acids; D001622:Betaine; C002889:gamma-butyrobetaine; C050147:3-(2,2,2-trimethylhydrazine)propionate; D000255:Adenosine Triphosphate; D002331:Carnitine
Vliianie novogo strukturnogo analoga gamma-butirobetaina-- 3-(2,2,2-trimethylgidraziniĭ)propionat (TGP) na soderzhanie karnitina, karnitinzavisimoe okislenie zhirnykh kislot i nekotorye pokazateli énergeticheskogo obmena v miokarde.