Co-existence of glicentin and peptide YY in colorectal L-cells in cat and man. An electron microscopic study.
Electron microscopic immunocytochemistry using protein A-gold labelling of ultrathin sections revealed immunoreactive glicentin (gut-type glucagon) and peptide YY (PYY) in virtually all secretory granules in a population of L-type endocrine cells in feline colon and human rectum. The granules of the human glicentin/PYY cells were considerably smaller in size than those in the cat. In both species the results indicate co-existence of glicentin and PYY in the same secretory granules, despite the probable derivation of the two peptides from two different precursors.
D000818:Animals; D002415:Cats; D003106:Colon / Q000032:analysis* / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000032:analysis / Q000648:ultrastructure; D005934:Glucagon / Q000032:analysis* / Q000276:immunology; D006046:Gold; D006801:Humans; D007106:Immune Sera; D008854:Microscopy, Electron; D019894:Peptide YY; D010455:Peptides / Q000032:analysis* / Q000276:immunology; D052336:Proglucagon; D011498:Protein Precursors / Q000032:analysis* / Q000276:immunology; D012007:Rectum / Q000032:analysis* / Q000648:ultrastructure; D013045:Species Specificity; D013205:Staphylococcal Protein A
D007106:Immune Sera; D010455:Peptides; D011498:Protein Precursors; D013205:Staphylococcal Protein A; D019894:Peptide YY; D052336:Proglucagon; D006046:Gold; D005934:Glucagon