title: Metabolism of some essential minerals in ponies fed high levels of aluminum.
abstract: The effect of dietary aluminum on the absorption, retention and pathways of excretion of calcium, phosphorus, magnesium, zinc, iron and copper was studied in balance trials in mature ponies in a three by three latin square experiment. A basal diet consisting of one third each of oats, beet pulp and a commercial pelleted, complete horse ration and containing 336 ppm aluminum was supplemented with AlC1(3) . 6H2O. The middle and high level aluminum diets contained 1370 and 4500 ppm aluminum respectively. There was little difference in effect between the middle level aluminum and basal diets. The ponies were in negative phosphorus balance when fed the high level aluminum diet because phosphorus absorption was suppressed. Calcium absorption was unaffected by aluminum intake but the ponies were in negative calcium balance when fed the high aluminum diet due to the greater urinary excretion of calcium by the ponies. Presumably, calcium was excreted in urine because it was not utilized in the formation of bone crystal due to the lack of phosphate. Plasma calcium was elevated and plasma phosphorus was depressed when ponies were fed the high aluminum diet. Plasma hydroxyproline concentration was increased suggesting that bone turnover was increased due to aluminum effects on phosphorus and calcium metabolism. Magnesium, zinc, iron and copper metabolism were unaffected by aluminum intake.
mesh_terms: D000535:Aluminum / Q000008:administration & dosage* / Q000032:analysis / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003300:Copper / Q000378:metabolism; D004032:Diet; D006736:Horses / Q000378:metabolism*; D007501:Iron / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D008297:Male; D010758:Phosphorus / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
chemical_list: D010758:Phosphorus; D003300:Copper; D000535:Aluminum; D007501:Iron; D008274:Magnesium; D015032:Zinc; D002118:Calcium