Cortisol stimulation by recombinant interferon-alpha 2.
Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-alpha 2. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-alpha 2. Cortisol elevation was increased as weekly doses of interferon were increased (0-120 X 10(6) units). Recent clinical trials of interferons for treatment of neurological and malignant diseases provide a compelling need to understand the actions and side effects of exogenously administered interferons.
D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006854:Hydrocortisone / Q000096:biosynthesis* / Q000097:blood; D007370:Interferon Type I / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D013696:Temperature
D007370:Interferon Type I; D011994:Recombinant Proteins; D006854:Hydrocortisone