Synthesis of novel polyaminoetherurethaneureas and development of antithrombogenic material by their chemical modifications.
Novel polyaminoetherurethaneureas containing tertiary amino groups in the main chain were synthesized (PAEUU), quaternized (Q-PAEUU), and heparinized (H-PAEUU). Films of PAEUU showed a microphase separation, which was influenced by the quaternization and the heparinization. With increasing content of amino group, the water content of Q-PAEUU and the heparin content of H-PAEUU increased. The heparin-releasing rate from H-PAEUU into physiological saline solution was slow, but increased with increasing content of quaternary ammonium groups in the polymer. The water content, the heparin adsorption, and the heparin-releasing rate were controlled by the kind of quaternizing agent. The antithrombogenicity of the polyurethaneureas was improved by quaternization and very much by heparinization, and affected by the kind of quaternizing agent. Heparinization was indispensable for achieving antithrombogenicity of the polymer, although the antithrombogenicity of H-PAEUU was affected more strongly by the water content than by the heparin content. The surface free energy of these polymer films was also investigated.
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D004285:Dogs; D004987:Ethers / Q000138:chemical synthesis; D006493:Heparin; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D011108:Polymers / Q000138:chemical synthesis*; D011140:Polyurethanes / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship; D013499:Surface Properties; D013816:Thermodynamics; D013927:Thrombosis / Q000517:prevention & control*; D014508:Urea / Q000031:analogs & derivatives / Q000138:chemical synthesis; D014867:Water
D001672:Biocompatible Materials; D004987:Ethers; D011108:Polymers; D011140:Polyurethanes; D014867:Water; D014508:Urea; D006493:Heparin