title: Bladder smooth muscle dysfunction in patients with irritable bowel syndrome.
abstract: Urodynamic studies were carried out on 30 patients with irritable bowel syndrome and 30 matched controls. Fifty per cent of the irritable bowel patients compared with only 13% of the control group had evidence of bladder dysfunction (p = 0.006). In the irritable bowel group detrusor instability was observed in 10 patients compared with only one control subject (p = 0.008). A steep cystometrogram occurred in five irritable bowel patients and three controls (NS). Detrusor instability was most common in patients with a bowel habit characterised by alternating constipation and diarrhoea. This is the first study to provide objective evidence that patients with irritable bowel syndrome may have a disorder of smooth muscle or its innervation that is not confined to the gastrointestinal system.
mesh_terms: D000328:Adult; D000368:Aged; D003109:Colonic Diseases, Functional / Q000150:complications / Q000503:physiopathology*; D003248:Constipation / Q000150:complications / Q000503:physiopathology; D003967:Diarrhea / Q000150:complications / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009130:Muscle, Smooth / Q000503:physiopathology*; D001743:Urinary Bladder / Q000503:physiopathology*; D014549:Urinary Incontinence / Q000150:complications / Q000503:physiopathology; D014563:Urodynamics