[Penetration of cefotaxime into human bone marrow blood].
Concentrations of cefotaxime (CTX) in bone marrow blood and venous blood were examined with the passage of time in 21 cases which received operations of bone and joint. Concentrations of CTX in bone marrow blood at 30 minutes of a single intravenous administration 2 g each of CTX were found to be 85.2 +/- 24.5 micrograms/ml. Concentration ratio of CTX in bone marrow blood to that in venous blood was reached the peak at 120 minutes after administration. Concentrations of CTX observed were higher than the MIC of CTX against major pathogens responsible for the postoperative infections in orthopaedic field. The CTX, therefore, is expected to have an effective antibiotic in prophylaxis.
D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000517:prevention & control; D001853:Bone Marrow / Q000098:blood supply; D001842:Bone and Bones / Q000601:surgery*; D002439:Cefotaxime / Q000008:administration & dosage / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007596:Joints / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D014680:Veins
D002439:Cefotaxime