title: Minimizing between-kit variability in immunoassay for carcinoembryonic antigen by use of a common standard.
abstract: Between-laboratory agreement of CEA determinations collected in a multicenter study has been substantially improved (CV decreased from 60.4 to 21.6%) by converting the results from mass concentration units (ng/mL) of local kit standards to int. units/L of the international standard first IRP 73/601. Conversion factors for the kits most used were computed, during the same survey, from results of two analytical-recovery experiments in which control samples, supplemented with the international standard, were analyzed by participating laboratories (n = 96).
mesh_terms: D002272:Carcinoembryonic Antigen / Q000032:analysis*; D007118:Immunoassay; D011786:Quality Control; D011933:Reagent Kits, Diagnostic / Q000592:standards*; D012015:Reference Standards; D012044:Regression Analysis
chemical_list: D002272:Carcinoembryonic Antigen; D011933:Reagent Kits, Diagnostic