Bacteroides fragilis meningitis successfully treated with metronidazole after a previous failure with thiamphenicol.
A case of pyogenic meningitis caused by Bacteroides fragilis in a 72-year-old woman is reported. Although the isolate was susceptible to thiamphenicol, the patient did not respond to this drug. Metronidazole, which showed high bactericidal activity, was administered and achieved sterilization of the cerebrospinal fluid and complete clinical response.
D000368:Aged; D001442:Bacteroides Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D001441:Bacteroides fragilis / Q000187:drug effects; D005260:Female; D006801:Humans; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D008795:Metronidazole / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D003668:Pressure Ulcer / Q000150:complications / Q000382:microbiology; D013839:Thiamphenicol / Q000134:cerebrospinal fluid / Q000627:therapeutic use*
D008795:Metronidazole; D013839:Thiamphenicol