Kynurenines do not antagonise GABA in rat hippocampus.
Kynurenine and kynurenic acid are known to produce convulsions in rats and mice and it has been reported that kynurenine can displace GABA from its neuronal binding sites. The present study shows that neither kynurenine nor kynurenic acid are antagonist of GABA when tested on the rat hippocampal slice preparation. It is therefore unlikely that kynurenine seizures result from the blockade of inhibitory neurotransmission.
D000818:Animals; D003292:Convulsants / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D018756:GABA Antagonists; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D007736:Kynurenic Acid / Q000494:pharmacology*; D007737:Kynurenine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012978:Sodium Oxybate / Q000037:antagonists & inhibitors; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives
D003292:Convulsants; D018756:GABA Antagonists; C004480:4-amino-3-hydroxybutyric acid; D007737:Kynurenine; D005680:gamma-Aminobutyric Acid; D012978:Sodium Oxybate; D007736:Kynurenic Acid