title: Gentamicin removal during intermittent peritoneal dialysis.
abstract: Gentamicin removal during intermittent peritoneal dialysis was studied in 13 uremic patients. The peak serum level after 80 mg of gentamicin intravenous drip was 6.00 +/- 1.3 micrograms/ml with a serum half-life of 13.6 +/- 4.07 h. The gentamicin dialysate level did not correlate with the corresponding serum concentration. The peritoneal gentamicin clearance (10.0 +/- 3.65 ml/min) correlated with the rate of protein loss, but not with the peritoneal clearances of urea and creatinine. When 4% glucose dialysate was used, the clearance of the drug increased considerably along with the ultrafiltration rate. Adding gentamicin (5 micrograms/ml) to the dialysate resulted in a sustained serum drug level. The mechanism of gentamicin transport through the peritoneal membrane is discussed. The study demonstrated significant removal of gentamicin during intermittent peritoneal dialysis.
mesh_terms: D003404:Creatinine / Q000378:metabolism; D005839:Gentamicins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism; D014508:Urea / Q000378:metabolism; D014511:Uremia / Q000097:blood / Q000628:therapy
chemical_list: D005839:Gentamicins; D014508:Urea; D003404:Creatinine