Cytogenetic effects of airborne particulate matter in human lymphocytes in vitro.
City smog was collected in a heavily industrialized area and investigated for its ability to induce cytogenetic effects in human lymphocytes in vitro. Total extract of city smog was found to produce sister-chromatid exchanges and chromosomal aberrations in a dose-dependent manner. In addition cell-cycle delay was observed at higher concentrations of city smog extract. Results of cytogenetic testing are discussed with respect to cell-cycle kinetics.
D002869:Chromosome Aberrations; D003114:Colony-Forming Units Assay; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D008677:Metaphase / Q000187:drug effects; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D012854:Sister Chromatid Exchange / Q000187:drug effects; D012905:Smog / Q000009:adverse effects*
D009153:Mutagens; D012905:Smog