Relationship of plasma phencyclidine levels to phencyclidine discrimination in the pigeon.
Plasma phencyclidine levels were determined in pigeons trained to discriminate 1.5 mg/kg phencyclidine from saline under a second-order schedule using a color-tracking procedure. With both cumulative and non-cumulative dosing procedures, pigeons reliably discriminated plasma phencyclidine levels above 200 ng/ml. When the time course of phencyclidine discrimination was determined and compared with the time course of phencyclidine levels in plasma in a different group of birds, a similar relationship between discrimination and plasma phencyclidine was generally observed. Plasma phencyclidine levels did not correlate well with position responding observed in some birds after lower phencyclidine doses.
D000818:Animals; D010856:Columbidae; D003216:Conditioning, Operant; D004193:Discrimination Learning; D005795:Generalization, Stimulus; D008297:Male; D010622:Phencyclidine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
D010622:Phencyclidine