[Bone modeling in experimentally induced osteoporosis in rats].
Osteoporosis was experimentally induced in rats by ovariectomy (OVX), surgical excision of the sciatic nerve (NX), unilateral cordotomy (CX) and their combined operations. Each experimental group was sacrificed 12 or 24 weeks after the operation. Microdensitometrical findings, bone weight and the amount of tetracycline absorbed into the bone were examined and were compared with the control (sham op.) in order to study the bone modeling dynamics. The rats which underwent CX combined with OVX were given 1 alpha (OH)D3 and the effects of the drug were examined in a similar manner. It was concluded that bone formation decreased in OVX, that bone formation decreased and bone resorption increased simultaneously in NX, and that both bone formation and bone resorption increased in CX. 1 alpha (OH)D3 was considered to inhibit the progression of osteoporosis.
D000818:Animals; D001846:Bone Development / Q000187:drug effects; D001862:Bone Resorption / Q000187:drug effects; D005260:Female; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D010024:Osteoporosis / Q000188:drug therapy / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains
D006887:Hydroxycholecalciferols; C008088:alfacalcidol