title: [Changes in the histologic structure of the organs of immunogenesis during treatment with immunomodulators].
abstract: The effect of levamisole as well as thymic (thymalin and bone marrow (hemalin) immunomodulators on the immunogenesis organs in practically healthy animals were studied. The comparison of multiple parameters of morphological changes developing in the immunocompetent organs under the influence of immunomodulators was performed by means of so called "similarity ratio". Morphological changes in the central organs of immunogenesis were more severe after the administration of hemalin than after levamisole. The influence of immunomodulators on the peripheral organs of immunogenesis were more uniform. The results obtained in the experiments on healthy animals may serve the basis for a further morphological analysis of the immunomodulators effects under the conditions of the immune homeostasis disturbance.
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D006168:Guinea Pigs; D036341:Intercellular Signaling Peptides and Proteins; D007978:Levamisole / Q000494:pharmacology*; D008198:Lymph Nodes / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects*; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D010581:Peyer's Patches / Q000187:drug effects; D013154:Spleen / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects; D013951:Thymus Hormones / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D013951:Thymus Hormones; D007978:Levamisole; C032805:thymalin; C046163:hemalin
vernacular_title: Izmenenie gistologicheskoĭ struktury organov immunogeneza pri vozdeĭstvii immunomoduliatorov.