Intrathecal bombesin-induced inhibition of gastrointestinal transit: requirement for an intact pituitary-adrenal axis.
The role of the pituitary-adrenal axis in the inhibition of gastrointestinal transit caused by intrathecal administration of bombesin was examined. Bombesin (0.3-10 micrograms) slowed transit by this route in a dose-related manner. Either hypophysectomy or adrenalectomy prevented the inhibition of gastrointestinal transit associated with bombesin (10 micrograms, i.th.). The inhibitory gut effects of this peptide were not prevented in sham-operated rats. Intrathecal bombesin-induced inhibition of gastrointestinal transit is thus dependent upon an intact pituitary-adrenal axis.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D001839:Bombesin / Q000008:administration & dosage / Q000494:pharmacology*; D002840:Chromates / Q000378:metabolism; D002860:Chromium Radioisotopes; D004063:Digestion / Q000187:drug effects*; D007016:Hypophysectomy; D007278:Injections, Spinal; D007700:Kinetics; D008297:Male; D010902:Pituitary Gland / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D017670:Sodium Compounds
D002840:Chromates; D002860:Chromium Radioisotopes; D017670:Sodium Compounds; C028982:sodium chromate(VI); D001839:Bombesin