title: Biomechanical and biochemical studies of tendon healing after conservative and surgical treatment.
abstract: Based on clinical studies, it has been proposed that conservative treatment of Achilles tendon ruptures is feasible. However, no biomechanical or biochemical confirmation of this proposal has been presented. In the present investigation the biomechanical and biochemical properties of tendons treated surgically and conservatively after transverse tenotomy were studied. Sixty-eight New Zealand White rabbits were used. A transverse tenotomy of the plantaris longus tendon of the left hind leg was performed. In half of the animals the tenotomy was repaired with a criss-cross silk suture and the limb was immobilized; the other half were treated with immobilization alone. The immobilization was maintained for 4 weeks with a long-leg plastic splint in both groups. After 4, 8, and 16 weeks the tendons were examined regarding biomechanical and biochemical parameters. There were no detectable differences in biomechanical parameters or in tendon elongation between the groups, nor was there any difference in the total hydroxyproline content, the amount of mature and of immature collagen, or the water content. The present findings are compatible with previous favorable reports on conservative treatment of Achilles tendon ruptures and thus suggest interesting clinical possibilities.
mesh_terms: D000125:Achilles Tendon / Q000293:injuries; D000818:Animals; D001696:Biomechanical Phenomena; D001834:Body Water / Q000032:analysis; D003094:Collagen / Q000032:analysis; D006909:Hydroxyproline / Q000032:analysis; D007103:Immobilization; D008297:Male; D011817:Rabbits; D012421:Rupture; D013708:Tendon Injuries / Q000378:metabolism / Q000601:surgery / Q000628:therapy*; D013997:Time Factors; D014945:Wound Healing
chemical_list: D003094:Collagen; D006909:Hydroxyproline