title: Opiate-seeking behavior under conditions of methadone detoxification and removal.
abstract: This study was carried out to determine whether heroin-dependent persons, having completed methadone detoxification, can be maintained on an inert substance which has previously been associated with methadone. Forty heroin-dependent men and women were randomly allocated to either a "standard detoxification" group or a cordial substitution group. Results showed that subjects administered methadone-associated cordial after methadone detoxification could not be retained at the clinic for a time significantly beyond that of subjects in the standard detoxification group despite the inability of the subjects to accurately estimate methadone dosage. The role of cognitive factors is discussed.
mesh_terms: D000328:Adult; D003214:Conditioning, Classical; D005260:Female; D006556:Heroin Dependence / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D008691:Methadone / Q000494:pharmacology / Q000627:therapeutic use*; D012646:Self Administration
chemical_list: D008691:Methadone