Antinociceptive action of picrotoxin in the mouse.
Picrotoxin, an antagonist of GABA-associated chloride ionophores with convulsant activity, possesses antinociceptive activity in the hot-plate and writhing tests in the mouse. Analgesia produced by a subconvulsant dose of picrotoxin (0.75 mg/kg, s.c.) was reversed by naloxone (1.0 mg/kg, s.c.), atropine (5 mg/kg, i.p.), and methysergide (10 mg/kg, i.p.) in the jumping reaction (hot-plate test). These data indicate that opiate pathways, as well as cholinergic and serotoninergic pathways could be involved in the mechanism that underlies picrotoxin-induced analgesia. Furthermore, such results should be considered when interpreting the behavioral effects of picrotoxin.
D000700:Analgesics; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004745:Enkephalins / Q000502:physiology; D018756:GABA Antagonists; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D000700:Analgesics; D001285:Atropine; D004745:Enkephalins; D018756:GABA Antagonists; D008784:Methysergide; D009270:Naloxone; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid