Immunomodulation by tamoxifen and pergolide.
Treatment of rats with tamoxifen citrate or pergolide mesylate was as effective in inhibiting antibody formation and contact sensitivity skin reactions as was hypophysectomy. The immunocompetence of tamoxifen citrate- and pergolide mesylate-suppressed animals could be fully restored by additional treatment with prolactin or growth hormone.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003864:Depression, Chemical; D003877:Dermatitis, Contact / Q000276:immunology; D018492:Dopamine Antagonists; D004965:Estrogen Antagonists / Q000494:pharmacology; D004967:Estrogens / Q000502:physiology; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects*; D007165:Immunosuppression Therapy; D010479:Pergolide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011388:Prolactin / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D013629:Tamoxifen / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D018492:Dopamine Antagonists; D004965:Estrogen Antagonists; D004967:Estrogens; D013629:Tamoxifen; D010479:Pergolide; D011388:Prolactin; D013006:Growth Hormone