Hypermodal cells, hypomodal cells, and repetitive abortions.
The frequency of neither hypermodal cells (2N = 47) nor hypomodal cells (2N = 45) differed between lymphocytes of individuals experiencing repetitive spontaneous abortions (N = 429) and controls (N = 90). The same conclusion held when data were analyzed according to chromosome involved (sex chromosome, autosome) or other variables (e.g., prior reproductive outcome). A study of this relatively large sample failed to confirm findings of smaller and sometimes uncontrolled studies. Hypermodal cells do not necessarily serve as a clue to meiotic instability and in turn probably do not identify couples at risk for recurrent aneuploidy.
D000026:Abortion, Habitual / Q000235:genetics*; D000782:Aneuploidy; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D011247:Pregnancy; D012306:Risk