title: [Development of neutral and bifunctional radiopharmaceuticals using 62Cu-dithiosemicarbazone (DTS) chelate--basic studies on 64Cu chelates].
abstract: Recent plausibility of generator produced 62Cu, a positron emitter is attracting the interest of those working in the development of bifunctional radiopharmaceuticals (BR). In our development of bifunctional radiopharmaceuticals containing a neutral dithiosemicarbazone (DTS) metal chelate, tertiary (p-DPA-DTS) and quaternary (p-TPA-DTS) amino DTS derivatives were synthesized. As for the basic understanding of their divalent metal (Cu2+, Ni2+, Zn2+) complex formation and stability, spectrophotometrical studies were carried out, comparatively with KTS. Upon assessment of preferential behavior of Cu chelate, the radiolabeled 64Cu-DTS derivative chelates were tested in mice, and potential use with 62Cu in positron nuclear medicine is discussed.
mesh_terms: D000818:Animals; D002614:Chelating Agents; D003300:Copper; D051379:Mice; D011868:Radioisotopes; D013882:Thiosemicarbazones; D014018:Tissue Distribution
chemical_list: D002614:Chelating Agents; D011868:Radioisotopes; D013882:Thiosemicarbazones; C015848:dithiosemicarbazone; D003300:Copper