Imprints of virus infection: can paramyxoviruses permanently modify triacylglycerol metabolism?
We have examined whether the passage of a paramyxovirus in a cell (BGM, African green monkey kidney) or animal (Swiss mouse) can permanently modify its metabolism. In an in vitro model in which cells had been cured of a measles virus persistent infection, the cells retained the modifications affecting lipid metabolism and composition induced during the infection. In a canine distemper virus mouse model, the same virus-induced modifications were observed in mice after the virus had been eliminated.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D002472:Cell Transformation, Viral; D004216:Distemper / Q000378:metabolism*; D004217:Distemper Virus, Canine / Q000235:genetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008820:Mice, Obese; D012016:Reference Values; D014280:Triglycerides / Q000378:metabolism*
D014280:Triglycerides