Baclofen treatment in a patient with tardive dystonia.
The use of baclofen, a structural analog of gamma-aminobutyric acid (GABA), is described in the treatment of a patient with tardive dystonia. The patient, a woman with a clinical diagnosis of Alzheimer's disease, developed tardive dystonia after 8 weeks of haloperidol therapy and experienced complete remission of her dystonia while taking baclofen 60 mg/day. This case suggests that baclofen may facilitate remission of tardive dystonia in some cases and provides a basis for further investigation.
D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy; D001418:Baclofen / Q000627:therapeutic use*; D004421:Dystonia / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans
D001418:Baclofen; D006220:Haloperidol