[Phospholipid biosynthesis in the lungs in a chronic inflammatory bronchopulmonary process].
Glycerokinase, glycerophosphate dehydrogenase, glycerophosphate acyltransferase activity, glycerophosphate, dioxiacetonphosphate level and in vivo incorporation of (U-14C)-glucose into the lung phospholipid structure were studied in normal rats and in conditions of chronic bronchopulmonary inflammation. The inhibition of glycerokinase and glycolytic ways of glycerophosphate formation was demonstrated. The data obtained have shown that glucose incorporation into phosphatidyl cholines, phosphatidyl glycerols and phosphatidyl ethanolamines was decreased, while the incorporation of radioactivity into the sphingomyelins and lysophosphatidyl cholines was significantly activated.
D000818:Animals; D001996:Bronchopneumonia / Q000201:enzymology*; D002908:Chronic Disease; D005947:Glucose / Q000378:metabolism; D008168:Lung / Q000201:enzymology*; D008297:Male; D010743:Phospholipids / Q000096:biosynthesis*; D011663:Pulmonary Surfactants / Q000096:biosynthesis; D011817:Rabbits
D010743:Phospholipids; D011663:Pulmonary Surfactants; D005947:Glucose
Biosintez fosfolipidov v legkikh pri khronicheskom vospalitel'nom bronkholegochnom protsesse.