Further confirmation of heterogeneity of the rat striatum: different mosaic patterns of dopamine fibers after administration of methamphetamine or reserpine.
Heterogeneity of adult rat neostriatum has been studied by fluorescence histochemistry. The distribution of dopamine nerve fibers and terminals, known normally to be homogeneous, tended to become heterogeneous after administration of methamphetamine or reserpine. Both drugs caused mosaic formations of fluorescent dopamine axons and terminals, though a minor difference was present in the pattern of distribution. The results indicate that the striatum possesses at least two types of dopamine nerve terminals, sensitive and relatively insensitive for the two catecholamine depletors.
D000818:Animals; D003342:Corpus Striatum / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D008856:Microscopy, Fluorescence; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology*
D008694:Methamphetamine; D012110:Reserpine; D004298:Dopamine