Effect of radiation-induced reduction of nitroimidazoles on biologically active DNA.
Radiation-chemical reductions have been carried out with several nitroimidazoles. Reduction of these drugs in the presence of single-stranded phi chi 174 DNA causes extensive lethal damage. However, relatively stable (end) products, do not contribute to the damage, although glyoxal is potentially toxic. This demonstrates that a short-lived intermediate in the reduction process is responsible. Further, the quantity of damage in the DNA depends on both dose (reduction)-rate and also the nature of the drug.
D003090:Coliphages; D004277:DNA, Single-Stranded; D004279:DNA, Viral; D008795:Metronidazole / Q000494:pharmacology / Q000528:radiation effects; D008920:Misonidazole / Q000494:pharmacology / Q000528:radiation effects; D009593:Nitroimidazoles / Q000494:pharmacology* / Q000528:radiation effects; D009950:Ornidazole / Q000494:pharmacology / Q000528:radiation effects; D010084:Oxidation-Reduction; D011854:Radiochemistry
D004277:DNA, Single-Stranded; D004279:DNA, Viral; D009593:Nitroimidazoles; D008795:Metronidazole; D009950:Ornidazole; D008920:Misonidazole