[Prevention of a disorder in the electrical stability of the heart in experimental myocardial infarct by using preliminary adaptation to brief stress exposures and the antioxidant ionol].
Preliminary adaptation to short-term stress was shown to prevent the fall of the heart fibrillation threshold and its increased ectopic activity which is usually observed in experimental myocardial infarction. This protective effect involves an enhanced activity of the organism's antioxidant systems. On this basis, synthetic antioxidant ionol was applied to prevent disturbances of heart electric stability in infarction. Ionol completely prevented the decrease in the electric threshold and the increase in ectopic activity of the heart in experimental infarction, demonstrating thereby an anti-arrhythmic effect.
D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology / Q000517:prevention & control*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D003327:Coronary Disease / Q000150:complications / Q000503:physiopathology; D004594:Electrophysiology; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*; D013997:Time Factors
D002084:Butylated Hydroxytoluene
Preduprezhdenie narusheniia élektricheskoĭ stabil'nosti serdtsa pri éksperimental'nom infarkte miokarde s pomoshch'iu predvaritel'noĭ adaptatsii k korotkim stressovym vozdeĭstviiam i antioksidanta ionola.