Effect of zinc deficiency on mucosal hyperplasia following 70% bowel resection.
We evaluated the effect of zinc deficiency on the development of mucosal hyperplasia in male Sprague-Dawley rats following 70% small-bowel resection: 20 underwent 70% jejunoileal resection, another 20 were sham operated. Half of each group were made zinc deficient by force-feeding technique. Operations were then performed, and feedings were continued for another 9 days. While mucosal weight did not differ between zinc-deficient and zinc-replete animals, whether or not they underwent resection, mucosal protein and DNA levels were decreased in both resected and sham-operated, zinc-deficient animals. Functional indices were also affected. Maltase activities were decreased in zinc-deficient animals in the midileum. Mucosal zinc-dependent enzymes, alkaline phosphatase and leucine aminopeptidase, were likewise depressed in zinc-deficient animals. Findings suggest that zinc deficiency in short-bowel syndrome will likely impair mucosal hyperplasia.
D000818:Animals; D004247:DNA / Q000378:metabolism; D006965:Hyperplasia / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology*; D008286:Malabsorption Syndromes / Q000473:pathology*; D008297:Male; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D012778:Short Bowel Syndrome / Q000378:metabolism / Q000473:pathology*; D015032:Zinc / Q000172:deficiency*
D004247:DNA; D015032:Zinc