Internalization and transport of mouse beta-interferon into the cell nucleus.
An electron microscopic technique employing postembedding immunolabeling was used to identify unmodified, intracellular MuIFN-beta molecules. The MuIFN-beta was rapidly internalized by receptor-dependent endocytosis and within three minutes a majority of internalized MuIFN-beta molecules was detected within the cell nucleus.
D000818:Animals; D001693:Biological Transport, Active; D002467:Cell Nucleus / Q000378:metabolism*; D004705:Endocytosis; D007370:Interferon Type I / Q000378:metabolism*; D007739:L Cells / Q000378:metabolism / Q000648:ultrastructure; D051379:Mice
D007370:Interferon Type I