Increases in adrenal catecholamine secretion and adrenal sympathetic nerve unitary activities with aging in rats.
Changes in sympathoadrenal medullary functions with age were investigated using urethane-chloralose anesthetized Wistar rats between about 100-900 days after birth. Although secretion rates of adrenaline and noradrenaline from the adrenal gland under resting conditions varied widely among animals, they gradually increased after 300 days and reached a level 2-4 times higher at 800-900 days compared with that of 100 days. Sympathetic nerve efferent unitary activity at resting conditions was also increased during aging in a manner similar to the catecholamine secretion rates.
D000200:Action Potentials; D000311:Adrenal Glands / Q000294:innervation / Q000378:metabolism*; D000320:Adrenergic Fibers / Q000502:physiology*; D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D002395:Catecholamines / Q000378:metabolism* / Q000502:physiology; D004837:Epinephrine / Q000378:metabolism / Q000502:physiology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines; D009638:Norepinephrine; D004837:Epinephrine