[Effect of neuroleptics on the epileptic process].
Using the parameters of the special synchronization of cortical biopotentials, the authors studied changes in the function of the cerebral cortex in patients with the generalized form of epilepsy with a further progression of the disease and under the effect of the typical neuroleptic haloperidol and atypical neuroleptic clozapine. These drugs have been found to act differently on the epileptic process and on the effects of the hyperventilation test, which appears to be due to their differing ability to block receptors of the nigrostriatal and mesolimbic dopaminergic systems. The data have shown that haloperidol increases the risk of the development of epileptic attacks while clozapine reduces epileptic manifestations.
D000927:Anticonvulsants; D002540:Cerebral Cortex / Q000503:physiopathology*; D003024:Clozapine / Q000494:pharmacology; D003344:Cortical Synchronization; D003984:Dibenzazepines; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D006220:Haloperidol / Q000633:toxicity; D006801:Humans; D012119:Respiration
D000927:Anticonvulsants; D003984:Dibenzazepines; D003024:Clozapine; D006220:Haloperidol
O vliianii neĭroleptikov na épilepticheskiĭ protsess.