Laboratory diagnosis in thyroid auto-allergic diseases.
Different parameters of humoral and cellular immunologic sensitization have been described in thyroid autoallergic disease, however, the percutaneous biopsy of the gland remains as one of the principal parameters of diagnostic confirmation, wherein the possible error of the sample being taken in an area not affected by the disease. The present study assesses two different parameters of immunologic sensitization, humoral and cellular as they are determination of thyroid antimicrosomal antibodies by hemagglutination and leukocyte inhibition migration tests against the same microsomal antigen. Both types of sensitization are proposed as being relevant, and can be found present alone or combined in the same patient, which suggests that the determination of antibodies is the most useful proof with diagnostic motives, but this should be followed by the determination of leukocyte inhibition migration when the result is negative.
D000917:Antibody Formation; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology; D002464:Cell Migration Inhibition; D006386:Hemagglutination Tests; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D007962:Leukocytes / Q000276:immunology; D008213:Lymphocyte Activation; D008861:Microsomes / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis* / Q000276:immunology
D001323:Autoantibodies; D007136:Immunoglobulins