[Concentration of anti-brain antibodies in the blood of patients with diffuse toxic goiter and thyrotoxic encephalopathy].
The content of anticerebral antibodies was studied in the peripheral blood of 10 healthy persons, 42 patients with diffuse toxic goiter and 25 patients with thyrotoxic encephalopathy. It was determined by a method of passive hemagglutination using a human brain protein extract as an antigen. In the healthy persons antibodies to cerebral antigens were undetectable whereas in 24 of 42 patients with diffuse toxic goiter without signs of the nervous system involvement they were detected (log2 titer--2.3 +/- 0.36). Most of them had polyvalent allergy, thyrotoxicosis recurrence or neuroinfection. Anticerebral antibodies were detected in 88% of the patients with thyrotoxic encephalopathy and their titer (5.6 +/- 0.66) significantly exceeded that in the patients with diffuse toxic goiter without encephalopathy. A possible reason for the appearance of anticerebral antibodies in patients was discussed. The autoimmune nature of thyrotoxic encephalopathy was assumed.
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology; D001921:Brain / Q000276:immunology*; D001927:Brain Diseases / Q000209:etiology / Q000276:immunology*; D006111:Graves Disease / Q000150:complications / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D012008:Recurrence
D001323:Autoantibodies
Soderzhanie protivomozgovykh antitel v krovi bol'nykh diffuznym toksicheskom zobom i tireotoksicheskoĭ éntsefalopatieĭ.