title: Azathioprine shock.
abstract: Azathioprine has been used as an immunosuppressant for over 20 years in cancer chemotherapy, organ transplantation and diseases with confirmed or suspected immune mechanisms. A hypersensitivity reaction manifesting as fever, rash, myalgia and a neutrophil leucocytosis occurring about 2 weeks after exposure is well documented and has been confirmed by challenge testing. Hypotensive reactions are less common but potentially fatal; a case is reported where repeat exposure resulted in profound circulatory collapse responding only to intervention with inotropic agents.
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced*; D001379:Azathioprine / Q000009:adverse effects*; D006801:Humans; D008297:Male
chemical_list: D001379:Azathioprine