Laser endarterectomy: a comparison of thrombotic potential following CO2 laser vs surgical endarterectomy.
Although laser endarterectomy has recently been suggested as useful in the treatment of arteriosclerotic obstructions, the "in vivo" clotting effects have not been well delineated. In this study, the common carotid and femoral arteries of ten mongrel dogs were exposed, and alternating 1 cm segments of each artery were treated with surgical endarterectomy and low-powered CO2 laser endarterectomy. Segments were then harvested, and subjected to histologic examination and vascular prostacyclin synthesis determinations, as measured by 6-keto PFG1a radioimmunoassay. Gross examination and light and scanning electron microscopy showed increased platelet aggregation and more extensive damaging of the underlying media of the laser compared to the surgical segments. Six-keto PFG1a levels were significantly lower (p = 0.001) in the laser compared to surgical sites (mean 232 +/- 72 pg/mg vs 515 +/- 144 pg/mg), or controls (895 +/- 337 pg/mg). These findings suggest that laser endothelial evaporation leads to increased thrombotic potential in the early post-operative period in comparison to surgical endarterectomy.
D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis; D000818:Animals; D003327:Coronary Disease / Q000209:etiology* / Q000628:therapy*; D003331:Coronary Vessels; D004285:Dogs; D004691:Endarterectomy / Q000379:methods*; D007834:Lasers; D008855:Microscopy, Electron, Scanning; D010974:Platelet Aggregation; D011183:Postoperative Complications; D011863:Radioimmunoassay
D015121:6-Ketoprostaglandin F1 alpha