[Kinetics of the excretion of a membrane-active macroheterocycle from the body in mice].
The study of the excretion kinetics of N-(3H-aminoacetyl)-I-aza-4,7,10,13-tetraoxacyclopentadecane hydrochloride and its metabolites with the mouse urine and feces showed a high relative effectiveness of the urinary excretion (only some 2% of the dose is excreted with the feces). It was also found that there occurs an intensive biotransformation of the compound yielding free and water-soluble metabolites.
D000818:Animals; D001711:Biotransformation; D002855:Chromatography, Thin Layer / Q000379:methods; D005243:Feces / Q000032:analysis; D006571:Heterocyclic Compounds / Q000378:metabolism*; D007476:Ionophores / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051379:Mice; D013997:Time Factors
D006571:Heterocyclic Compounds; D007476:Ionophores
Kinetika vyvedeniia membranoaktivnogo makrogeterotsikla iz organizma mysheĭ.