[Changes in the cyclic nucleotide level and the inhibition of human thrombocyte aggregation in 3-hydroxypyridine exposure].
The effect of six 3-oxypiridine derivatives (at a concentration of 10(-3) and 5 X 10(-3) M) on cyclic nucleotide level in human platelets and platelet aggregation was studied. Five 3-oxypiridine derivatives were shown to depress platelet aggregation, four of them causing the increase in cAMP platelet level. The correlation between antiaggregation activity of 3-oxypiridine derivatives and their ability to rise cyclic nucleotide level in human platelets is discussed.
D001241:Aspirin / Q000494:pharmacology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009712:Nucleotides, Cyclic / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*
D009712:Nucleotides, Cyclic; D011725:Pyridines; C023500:3-hydroxypyridine; D001241:Aspirin
Izmenenie urovnia tsiklicheskikh nukleotidov i tormozhenie agregatsii trombotsitov cheloveka pri deĭstvii 3-oksipiridinov.