title: [Determination of piperazine in hen eggs with HPLC following oral administration].
abstract: After oral administration of piperazine citrate to hens, this antihelmintic agent appeared unchanged in the eggs. After a therapeutic dose of ca. 0.9 g piperazine citrate per hen, a maximum level of 1.5 mg piperazine/kg egg was found two days after the application. The elimination half-life was 29 h and piperazine was found in the eggs up to 17 days after administration (limit of detection: 1 microgram/kg). Piperazine determination was performed by HPLC of the dansylderivative after clean-up by TLC.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002645:Chickens; D002851:Chromatography, High Pressure Liquid; D003619:Dansyl Compounds / Q000032:analysis; D004531:Eggs / Q000032:analysis*; D005260:Female; D006207:Half-Life; D000077489:Piperazine; D010879:Piperazines / Q000032:analysis* / Q000378:metabolism
chemical_list: D003619:Dansyl Compounds; D010879:Piperazines; D000077489:Piperazine
vernacular_title: Bestimmung von Piperazin in Hühnereiern mit HPLC nach peroraler Applikation.