title: The in vitro effect of amrinone on thromboxane B2 synthesis in human whole blood.
abstract: Thromboxane B2 production in vitro in human whole blood was inhibited at pharmacological levels of amrinone. There was no observed effect on prostacyclin production as measured by 6-ketoprostaglandin F1 alpha levels. The biochemical basis for the inhibition of platelet aggregation by amrinone and the inter-relationships between arachidonic acid metabolism, c-AMP and Ca2+ levels are discussed.
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis*; D000631:Aminopyridines / Q000494:pharmacology*; D000676:Amrinone; D001773:Blood Cells / Q000187:drug effects / Q000378:metabolism*; D003094:Collagen / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D013929:Thromboxane B2 / Q000096:biosynthesis*
chemical_list: D000631:Aminopyridines; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D003094:Collagen; D000676:Amrinone