title: [Determination of the specific activity and biological availability of Soviet-made furosemide].
abstract: Experiments on mice, rats and dogs showed that furosemide manufactured in the USSR is not inferior by its specific activity to furosemide manufactured abroad. Furosemide manufactured in the USSR and furosemide-substance made in Finland were compared at three doses--1, 5 and 25 mg/kg. The bioavailability of furosemide tablets manufactured in the USSR and that of "Polfa" production tablets studied on rats (5 and 25 mg/kg) and dogs (40 mg) appeared to be identical.
mesh_terms: D000818:Animals; D001682:Biological Availability; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005387:Finland; D005665:Furosemide / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D009318:Natriuresis / Q000187:drug effects; D011044:Poland; D051381:Rats; D013607:Tablets; D014586:USSR
chemical_list: D013607:Tablets; D005665:Furosemide
vernacular_title: Opredelenie spetsificheskoĭ aktivnosti i biologicheskoĭ dostupnosti otechestvennogo furosemida.