Skin permeability of various non-steroidal anti-inflammatory drugs in man.
The skin permeabilities of a series of eight salicylates and ten non-steroidal anti-inflammatory drugs were investigated in human subjects. The logarithms of % absorption through intact skin and of n-octanol/water partition coefficients (log P) of the test compounds were plotted against one another, and a parabolic relationship was obtained in both compound series.
D000042:Absorption; D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D012459:Salicylates / Q000008:administration & dosage / Q000378:metabolism; D012867:Skin / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D012459:Salicylates