title: [Prevention of atrial flutter with Chinidin retard].
abstract: The action of the preparation Chinidin retard, tablets of 0.250, was studied with a view to its effects of preserving the recovered sinus rhythm after regularization in 32 patients with atrial flutter, as well as its effect on central hemodynamics and functions of parenchymal organs. The successful anti-recurrence treatment and the maintenance of lasting sinus rhythm after regularization in 90.6 per cent of the patients for more than 6 months with only 2 tablets daily, provided grounds to recommend chinidin retard as an agent of choice for long-term prophylaxis against the paroxysm of atrial flutter. The preparation has a lightly manifested negative inotropic action, but with the doses administered--it leads to no left-ventricular dysfunction. The long-term treatment with chinidin retard has no toxic effect on parenchymal organs.
mesh_terms: D001282:Atrial Flutter / Q000503:physiopathology / Q000517:prevention & control*; D003692:Delayed-Action Preparations; D004341:Drug Evaluation; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011802:Quinidine / Q000009:adverse effects / Q000627:therapeutic use*; D012008:Recurrence; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D013607:Tablets; D011802:Quinidine
vernacular_title: Profilaktika na predsŭrdnoto mŭzhdene s Chinidin retard.