Computed tomography and pattern reversal visual evoked potentials in chronic schizophrenic patients.
Eighteen chronic schizophrenic subjects treated with a uniform dosage (4-6 mg/day p.o.) of haloperidol were submitted to computed tomography (CT) and to pattern reversal visual evoked potentials (VEPs). Compared to age-matched controls, schizophrenic patients showed lateral and third ventricular enlargement, greatly delayed VEP latencies and reduced amplitudes. These abnormalities were not related to diagnostic subgroups. Schizophrenic patients with a positive family history for major psychiatric disorders showed normal CT scan measures and greatly abnormal VEP measures, whereas patients with a negative family history showed CT scan signs of atrophy and less pronounced VEP abnormalities.
D000328:Adult; D001921:Brain / Q000473:pathology*; D002908:Chronic Disease; D005074:Evoked Potentials, Visual; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D014795:Visual Pathways / Q000503:physiopathology*
D006220:Haloperidol