Pulmonary hypertension in hydralazine induced systemic lupus erythematosus: association with C4 null allele.
A patient who developed pulmonary hypertension and systemic lupus erythematosus as a complication of hydralazine therapy is reported. She was a slow acetylator and in addition was found to have a null allele at the C4A locus.
D000483:Alleles; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015236:HLA-C Antigens; D006801:Humans; D006830:Hydralazine / Q000009:adverse effects*; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced / Q000235:genetics*; D008875:Middle Aged
D006680:HLA Antigens; D015236:HLA-C Antigens; C039966:HLA-C*04 antigen; D006830:Hydralazine