[Effect of three retinoids on the growth of experimental tumors].
Influence of retinoid C17-diester retinyldimedone and L-tocopherylretinoate on the growth of transplanted tumors was investigated in F1 (C57Bl/6 X CBA) strain of mice. The retinoids studied proved to be less toxic than retinoic acid. Both retinoid C17-diester and L-tocopherylretinoate reduced growth of cervical cancer, while retinyldimedone inhibited growth of Lewis carcinoma (lung tumor) and of stomach carcinoma.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology*; D012176:Retinoids / Q000494:pharmacology* / Q000633:toxicity; D014212:Tretinoin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000633:toxicity; D014810:Vitamin E / Q000031:analogs & derivatives / Q000494:pharmacology / Q000633:toxicity
D012176:Retinoids; C050149:tocopheryl retinoate; C050148:5-methyl-7-(2,6-dimethyl-6-ethoxycarbonyl-3-oxo-1-cyclohexyl)-2,4,6-heptatrienoic acid; D014810:Vitamin E; D014212:Tretinoin; C023048:retinylidene dimedone
Vliianie trekh retinoidov na rost éksperimental'nykh opukholeĭ.