Tissue concentrations of coenzyme Q in liver of rats intoxicated by carbon tetrachloride.
The protective action of hepatic cells of the coenzyme CoQ10 was checked against the well-known hepatolesive agent carbon tetrachloride (CCl4). It was found that CoQ10 pretreatment strongly reduced the CCl4-induced lesions in rat liver. The most important of these lesions was a marked steatosis, together with focal necrosis, Kupffer-cell reaction and signs of phlogosis and fibroblastic proliferation. The protective effects of CoQ10 seemed to be dose-dependent. The variation of CoQ9 concentration in the liver was not significant at any of the doses used.
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D003067:Coenzymes; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology
D003067:Coenzymes; D014451:Ubiquinone; D002251:Carbon Tetrachloride; C024989:coenzyme Q10; C030571:ubiquinone 9