title: [Monitoring of cardiac output during use of bupivacaine 0.75% by ventriculography (99mTC)].
abstract: Fifteen patients undergoing orthopaedic surgery on the lower limbs were give continuous epidural anaesthesia with bupivacaine 0.75%. It was looked after changes in heart frequency, beat volume and changes in heart rhythm. Changes in cardiac output were investigated by ventriculography with 99mTC during 4 periods--10 min before and 10, 20 and 30 min after epidural blockade--the cardiac output was measured by a computer mathematically. Each patient received 2 mg/kg body weight of bupivacaine 0.75%. Besides the observation of blood pressure, heart rate and electrocardiogram the venous plasma levels of bupivacaine were measured up to 60 min after blockade. The results showed no changed in cardiac output. Except for one case with bradycardia--which could be treated with atropine--no changes in heart frequency occurred. Tachy- or bradycardia was not seen at all. Besides rare respiratory sinus arrhythmia no arrhythmia could be detected. The venous plasma levels of bupivacaine increased after 30 min up to 0.81 microgram/ml. The highest concentration measured was 1.45 microgram/ml 10 min after injection of bupivacaine. According to the results of the study the following statement can be given: Following bupivacaine 0.75% (2 mg/kg) given epidurally no changes in cardiac output, no changes in beat frequency, no pathological changes in cardiac rhythm and no specific cardiac toxicity related to bupivacaine 0.75% could be found in this study.
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D002045:Bupivacaine / Q000009:adverse effects*; D002302:Cardiac Output / Q000187:drug effects*; D004562:Electrocardiography; D006331:Heart Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D007866:Leg / Q000601:surgery; D008991:Monitoring, Physiologic; D011877:Radionuclide Imaging; D013667:Technetium
chemical_list: D013667:Technetium; D002045:Bupivacaine
vernacular_title: Die Uberwachung der Herzleistung bei Anwendung von Bupivacain 0.75% mit Hilfe der Ventrikulographie (99mTC).