Enhancement of cardiac vagal action during ischaemia of the sino-atrial node.
The effect of ischaemia of the sino-atrial node on cardiac vagal action was studied in anaesthetized dogs. The cut, cardiac end of the right vagus nerve was stimulated with a standard supramaximal stimulus every 10 s. The arterial supply to the sinoatrial node was occluded for periods of 1-3 min during this intermittent vagal stimulation. Vagal action on heart rate was potentiated during ischaemia of the sino-atrial node.
D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D006321:Heart / Q000294:innervation; D006339:Heart Rate; D007511:Ischemia / Q000503:physiopathology*; D012849:Sinoatrial Node / Q000503:physiopathology*; D014630:Vagus Nerve / Q000503:physiopathology*