Two sulfur-containing ansamycin antibiotics from Streptomyces albolongus.
Two sulfur-containing ansamycin antibiotics were isolated from the culture broth of Streptomyces albolongus C-46366; the major one was identical with awamycin and the minor one was a new ansamycin antibiotic, ansathiazin. Their structures were elucidated from their reactions and spectroscopic analyses. These antibiotics were active against gram-positive bacteria, acid-fast bacteria and a protozoan.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D006094:Gram-Positive Bacteria / Q000187:drug effects; D047029:Lactams, Macrocyclic; D009682:Magnetic Resonance Spectroscopy; D009161:Mycobacterium / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism*; D013768:Tetrahymena / Q000187:drug effects
D000900:Anti-Bacterial Agents; D047029:Lactams, Macrocyclic