Lack of antiglomerular basement membrane antibody binding to alveolar membranes after hydrocarbon exposure in rats.
A causal relationship has been proposed for the development of Goodpasture's syndrome and hydrocarbon (gasoline) exposure in man. Infusion of antiglomerular basement membrane antibody into rats subjected to gasoline inhalation did not result in linear binding to alveolar basement membranes suggesting that the endothelial barriers remained intact despite administration of near lethal doses of gasoline.
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology*; D001554:Benzene / Q000633:toxicity; D004727:Endothelium / Q000276:immunology; D005740:Gases; D005742:Gasoline / Q000633:toxicity; D006838:Hydrocarbons / Q000633:toxicity*; D007678:Kidney Glomerulus / Q000276:immunology*; D008297:Male; D011650:Pulmonary Alveoli / Q000276:immunology*; D051381:Rats
D001323:Autoantibodies; D005740:Gases; D005742:Gasoline; D006838:Hydrocarbons; D001554:Benzene