Bronchiolocentric chronic lymphocytic leukemia.
Three patients presented with symptoms of severe dyspnea, radiologic evidence of bilateral pulmonary infiltrates, and one had diffuse wheezing on auscultation. Open-lung biopsies revealed a neoplastic lymphocytic infiltrate in an exquisitely bronchiolocentric distribution with relative sparing of the rest of the lung parenchyma. Two patients had a history of chronic lymphocytic leukemia (CLL), whereas pulmonary disease was the initial manifestation of the lymphoproliferative disorder in the third. Clinical and pathologic features of the three cases are discussed.
D000368:Aged; D001980:Bronchi / Q000473:pathology; D001982:Bronchial Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013256:Steroids / Q000627:therapeutic use
D013256:Steroids