A reinterpretation of tyramine sympathomimetic effect and tachyphylaxis.
In this commentary, the indirect sympathomimetic effect of tyramine and the phenomenon of tyramine tachyphylaxis are reinterpreted in terms of carrier-mediated exchange processes. Extracellular tyramine would exchange with intraterminal noradrenaline and, upon repeated tyramine administration, with a mixture of noradrenaline and tyramine progressively more enriched in the pharmacologically inactive amine.
D000320:Adrenergic Fibers / Q000187:drug effects; D000818:Animals; D009411:Nerve Endings / Q000187:drug effects; D051381:Rats; D013566:Sympathomimetics / Q000494:pharmacology*; D013618:Tachyphylaxis; D014439:Tyramine / Q000494:pharmacology*
D013566:Sympathomimetics; D014439:Tyramine