[Activity of key enzymes of cholesterol biotransformation and lipid content in the liver, aorta, adrenals and blood of rats exposed to chloroquine].
Intraperitoneal administration of chloroquine (50 mg/kg, 7 days) to rats was followed by the increase of cholesterol, its esters, triglycerides and phospholipids levels in tissues, the decrease of lysosomal cholesterol esterase and acyl-koA-cholesterol acyl transferase activity in the liver and the enhancement of the non-sedimentable activity of acid phosphatase and beta-galactosidase. At concentration range of 3.5 to 140 mM the drug inhibited the activity of cholesterol esterase in the rat liver lysosome fraction.
D000311:Adrenal Glands / Q000201:enzymology*; D000818:Animals; D001011:Aorta / Q000201:enzymology*; D001711:Biotransformation / Q000187:drug effects; D002738:Chloroquine / Q000633:toxicity*; D002784:Cholesterol / Q000378:metabolism*; D002788:Cholesterol Esters / Q000096:biosynthesis; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology*; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D002787:Sterol Esterase / Q000378:metabolism; D002785:Sterol O-Acyltransferase / Q000378:metabolism
D002788:Cholesterol Esters; D002738:Chloroquine; D002784:Cholesterol; D002785:Sterol O-Acyltransferase; D002787:Sterol Esterase
Aktivnost' kliuchevykh fermentov biotransformatsii kholesterina i soderzhanie lipidov v pecheni, aorte, nadpochechnikakh i krovi krys pri vozdeĭstvii khlorokhina.