title: Biosynthesis of lasalocid A. Metabolic interrelationships of carboxylic acid precursors and polyether antibiotics.
abstract: The metabolic interrelationships of isobutyrate, n-butyrate, and propionate in Streptomyces lasaliensis are established to show how these acids are used as precursors for the biosynthesis of the polyether antibiotic, lasalocid A.
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D002087:Butyrates / Q000378:metabolism*; D020148:Butyric Acid; D058610:Isobutyrates; D007832:Lasalocid / Q000096:biosynthesis*; D010084:Oxidation-Reduction; D011422:Propionates / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D002087:Butyrates; D058610:Isobutyrates; D011422:Propionates; D020148:Butyric Acid; C020380:isobutyric acid; C029658:propionic acid; D007832:Lasalocid