Measurement of stimulated dopamine release in the rat by in vivo voltammetry: the influence of stimulus duration on drug responses.
High-speed cyclic voltammetry at carbon fibre microelectrodes was used to monitor stimulated striatal dopamine (DA) release in the anaesthetised rat. The effects of metoclopramide, chlorpromazine, benztropine and dexamphetamine on DA release after 1 s and 10 s stimulations were investigated. The antagonists enhanced DA release most clearly with 1 s stimuli. Benztropine had no effect on DA release with the 10 s stimulations, but elevated release after 1 s trains. Dexamphetamine reduced release with 10 s stimuli but enhanced release after 1 s trains. The results are discussed in terms of neuronal DA uptake and releasable DA pool size.
D000818:Animals; D001590:Benztropine / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D003342:Corpus Striatum / Q000378:metabolism*; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D004563:Electrochemistry; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001590:Benztropine; D008787:Metoclopramide; D003913:Dextroamphetamine; D002746:Chlorpromazine; D004298:Dopamine