[Effect of Cavinton on convulsions caused by chemical substances].
Cavinton was shown to protect mice against convulsions induced by corazol, strychnine and thiosemicarbazide. In addition, cavinton exhibited a definite antagonism to convulsive reactions produced by systemic administration of penicillin to cats and a combined administration of penicillin (intramuscularly) with tryptophan metabolite, quinolinic acid (intracerebroventricularly). The anticonvulsant action of cavinton is suggested to be due to the involvement of the brain GABA- and serotonergic mechanisms. It is reasonable to test cavinton as a drug for treating some forms of epilepsy.
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002415:Cats; D004353:Drug Evaluation, Preclinical; D004569:Electroencephalography; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D013997:Time Factors; D014748:Vinca Alkaloids / Q000627:therapeutic use*
D000927:Anticonvulsants; D014748:Vinca Alkaloids; C013983:vinpocetine
Vliianie kavintona na sudorogi, vyzvannye khimicheskimi veshchestvami.