Evaluation of chemically-induced phototoxicity to aquatic organism using Paramecium as a model.
Phototoxicity evaluation using Paramecium aurelia as a model revealed that 4 out of 21 pesticides produced lethal toxicity to cells. Four commonly used synthetic dyes (bromophenol blue, rose bengal, benzanthrone and methylene blue) also exhibited toxicity. Well known phototoxic agents like hematoporphyrin, riboflavin, and anthracene produced positive phototoxic response. Psoralen, a DNA cross-linking agent, also produced phototoxicity to the cells. The results clearly demonstrate that the synergistic action of chemical agents and sunlight produce lethal effects to aquatic organism.
D000818:Animals; D000873:Anthracenes / Q000633:toxicity; D004396:Coloring Agents / Q000633:toxicity; D004785:Environmental Pollutants / Q000633:toxicity*; D006415:Hematoporphyrins / Q000633:toxicity; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism; D010247:Paramecium / Q000187:drug effects; D010575:Pesticides / Q000633:toxicity; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D012256:Riboflavin / Q000633:toxicity
D000873:Anthracenes; D004396:Coloring Agents; D004785:Environmental Pollutants; D006415:Hematoporphyrins; D010575:Pesticides; C034020:anthracene; D010100:Oxygen; D012256:Riboflavin