A case of amiodarone-induced hyperthyroidism and hepatitis: results of clinical laboratory and histological tests.
We report a case of amiodarone-induced hepatitis accompanied by hyperthyroidism in which estimations of amiodarone in blood and in the liver and histological examinations were performed at the start and end of a 3-month interval. Our observation demonstrates the persistence in the liver of amiodarone and its principal metabolite for 3 months after the drug was withdrawn. There was no correlation between the persistence of the drug, the elevation of enzyme levels, and the extent of histological damage in the liver.
D000638:Amiodarone / Q000009:adverse effects* / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000139:chemically induced*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged
D000638:Amiodarone