Inverted neurons in agyria. A Golgi study of a case with abnormal chromosome 17.
An anatomoclinical observation of agyria is reported. The karyotype revealed a partial deletion of the short arm of chromosome 17. The etiology of agyria is reviewed in the light of this chromosomal abnormality. In addition we describe the peculiar pattern of neurons in the cortex: Golgi stain demonstrated many inverted pyramidal cells in the superficial part of the cortical layer. The mechanism of this abnormality is discussed.
D000015:Abnormalities, Multiple / Q000235:genetics* / Q000473:pathology; D002540:Cerebral Cortex / Q000002:abnormalities*; D002869:Chromosome Aberrations; D002902:Chromosomes, Human, 16-18; D003878:Dermatoglyphics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009474:Neurons / Q000473:pathology*