Urinary cyclophosphamide assay as a method for biological monitoring of occupational exposure to cyclophosphamide.
Urine of twenty hospital workers was monitored for the excretion of the cytostatic drug cyclophosphamide using GC-MSD. The drug was found to be present above the detection limit of 0.5 microgram/24 h urine in five cases. A clear relationship between cyclophosphamide handling and the detectability of excretion existed. This method developed can be of use for biological monitoring studies directed toward the finding of exposure hazards.
D000328:Adult; D002849:Chromatography, Gas; D003520:Cyclophosphamide / Q000009:adverse effects / Q000652:urine*; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced*; D012907:Smoking
D003520:Cyclophosphamide