Imbalance of sex chromosomes, with gain of early-replicating X, in human solid tumors.
An imbalance of sex chromosomes was observed in several cases of solid tumors: colorectal, anal canal and breast carcinomas. Replication studies, using BUdR incorporation, show that in males there is a tendency towards a gain of early-replicating X and a deficiency of Y chromosomes. In females, there is a tendency towards a gain of early-replicating X and a loss of late-replicating X chromosomes. Although almost no replication studies have been published in the literature, making it impossible to distinguish between late- and early-replicating Xs, it is likely that a similar situation exists for several solid tumors other than those we have studied. A possible consequence of this imbalance is briefly discussed.
D001005:Anus Neoplasms / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics; D004261:DNA Replication; D004407:Dysgerminoma / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008545:Melanoma / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics; D012004:Rectal Neoplasms / Q000235:genetics; D012729:Sex Chromosome Aberrations; D012737:Sex Factors; D013736:Testicular Neoplasms / Q000235:genetics; D001749:Urinary Bladder Neoplasms / Q000235:genetics; D014960:X Chromosome; D014998:Y Chromosome