Evaluation of the renal scanning agent N-succinyldesferrioxamine B in dogs.
The mechanism of the excretion of 67 Ga-N-succinyldesferrioxamine B (SDF) was investigated in five healthy dogs. Comparison of the SDF clearance rates for whole blood and plasma as well as SDF renograms with those of 131 I-o-iodohippuric acid (OIH) and 111In-diethylenetriamine-pentaacetic acid (DTPA) revealed that SDF is cleared by glomerular filtration and not by an active tubular transport mechanism.
D000818:Animals; D003676:Deferoxamine / Q000031:analogs & derivatives* / Q000378:metabolism; D004285:Dogs; D005710:Gallium Radioisotopes / Q000097:blood*; D007465:Iodohippuric Acid / Q000378:metabolism; D007668:Kidney / Q000000981:diagnostic imaging*; D007678:Kidney Glomerulus / Q000098:blood supply; D004369:Pentetic Acid / Q000378:metabolism; D011877:Radionuclide Imaging
D005710:Gallium Radioisotopes; D007465:Iodohippuric Acid; D004369:Pentetic Acid; C044311:N-succinyldesferrioxamine B; D003676:Deferoxamine