Boronated monoclonal antibody 17-1A for potential neutron capture therapy of colorectal cancer.
The theoretical basis for boron neutron capture therapy (BNCT) derives from the reaction that occurs when a stable isotope, boron-10, is irradiated with thermal neutrons to produce an unstable intermediate, boron-11, which then undergoes instantaneous nuclear fission to yield lithium-7 and alpha particles.
D000911:Antibodies, Monoclonal / Q000302:isolation & purification / Q000627:therapeutic use*; D001895:Boron / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000532:radiotherapy*; D006801:Humans; D009502:Neutrons; D011868:Radioisotopes / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000532:radiotherapy*
D000911:Antibodies, Monoclonal; D011868:Radioisotopes; D001895:Boron