Synthesis and uptake of taurine by isolated human granulocytes.
The synthesis and uptake of taurine were studied in isolated human granulocytes. It was found that granulocytes were capable to metabolize L-cysteine to taurine, and to take up taurine from the incubation medium. The taurine uptake appeared to be temperature dependent, sodium dependent and competitively inhibited by beta--alanine.
D000328:Adult; D000409:Alanine / Q000494:pharmacology; D001667:Binding, Competitive; D001692:Biological Transport / Q000187:drug effects; D003545:Cysteine / Q000097:blood; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D012964:Sodium / Q000494:pharmacology; D013654:Taurine / Q000097:blood*; D013696:Temperature
D013654:Taurine; D012964:Sodium; D003545:Cysteine; D000409:Alanine