title: [Effects of pharmacological substances structurally close to gamma-aminobutyric acid on the synthesis, metabolism and membrane transport systems in the cerebral cortex of rats in vitro].
abstract: Effects of pantogam (calcium homopantotenate), piracetam, phenibut (beta-phenyl-GABA), sodium hydroxybutyrate and sodium valproate (depakine) at concentrations of 100 and 500 microM on the activities of glutamic acid decarboxylase, GABA-transaminase, Na, K- and Mg-ATPases, synaptosomal uptake and K+-stimulated release of 3H-GABA were studied in vitro. None of the compounds influenced the 3H-GABA uptake and activity of Mg-ATPase. Piracetam and phenibut stimulated slightly Na, K-ATPase. Phenibut and hydroxybutyrate exerted the inhibitory effect on GABA-transaminase activity. Hydroxybutyrate produced a moderate decrease of 3H-GABA release and suppressed the activity of glutamic acid decarboxylase.
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology
chemical_list: D005680:gamma-Aminobutyric Acid
vernacular_title: Vliianie farmakologicheskikh veshchestv, strukturno blizkikh gamma-aminomaslianoĭ kislote, na sintez, metabolizm i membrannye transportnye sistemy v kore mozga krys in vitro.