Formation of beta-peltatin-A methyl ether and coniferin by root cultures of Linum flavum.
Extracts of root cultures of Linum flavum contained high cytotoxic activity due to the presence of 1% beta-peltatin-A methyl ether of the dry mass. During chromatographic analysis of the cell extracts, coniferin was identified as the major uv-absorbing but noncytotoxic constituent with levels of up to 3% of the dry mass. Growth, culture appearance, and product accumulation varied greatly with the 2,4-D concentration in the medium.
D015084:2,4-Dichlorophenoxyacetic Acid / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000096:biosynthesis*; D002470:Cell Survival / Q000187:drug effects; D002934:Cinnamates / Q000096:biosynthesis*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010946:Plants, Medicinal / Q000378:metabolism*; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D002934:Cinnamates; C010499:beta-peltatin A methyl ether; D015084:2,4-Dichlorophenoxyacetic Acid; D011034:Podophyllotoxin; C016316:coniferin