title: Serotonin metabolism and the nature of monoamine oxidase in squid central nervous system.
abstract: Monoamine oxidase activity, using type A and type B substrates and inhibitors, was investigated in the central brain and synaptosomes prepared from the optic lobe of squid. Although substantial MAO activity towards serotonin (5-HT), phenylethylamine and tyramine was present, the enzyme could not be differentiated into the two subtypes previously described in the vertebrate central nervous system. However, this enzyme is functional since 5-HT levels, as identified by immunocytochemical procedures, are low in the squid nervous system and show significant increases in pargyline treated squids.
mesh_terms: D000818:Animals; D049832:Decapodiformes / Q000378:metabolism*; D005724:Ganglia / Q000378:metabolism*; D006651:Histocytochemistry; D007120:Immunochemistry; D007527:Isoenzymes / Q000378:metabolism*; D007700:Kinetics; D008995:Monoamine Oxidase / Q000378:metabolism*; D010293:Pargyline / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism*; D013574:Synaptosomes / Q000201:enzymology
chemical_list: D007527:Isoenzymes; D012701:Serotonin; D010293:Pargyline; D008995:Monoamine Oxidase