A recent aetiological study on facial clefting in Hungary.
A case-control epidemiological and family study was organized of 2024 index patients born between 1970 and 1976 affected by isolated cleft lip +/- cleft palate, isolated posterior cleft palate and multiple congenital abnormalities including facial clefting and of their matched control cases. The specific rate of affected parents and sibs was 2.4% and 4.2% in the isolated cleft lip +/- cleft palate sample, while 2.2% and 3.2% in the isolated posterior cleft palate group. The proportion of polygenic liability was about 77 +/- 8% in isolated cleft lip +/- cleft palate cases. Among teratogens, the triggering impact of certain anticonvulsants was confirmed.
D000015:Abnormalities, Multiple / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D002971:Cleft Lip / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D002972:Cleft Palate / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D005260:Female; D006801:Humans; D006814:Hungary; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000453:epidemiology; D012737:Sex Factors; D012907:Smoking; D013723:Teratogens
D013723:Teratogens