title: [Effect of penbutolol on the hemodynamics in patients with hypertensive disease].
abstract: It was found that a hypotensive effect of penbutolol used for treatment of 234 patients with hypertensive disease exceeded that of propranolol and developed at a dose of 20-80 mg a day at the end of the 2nd week of treatment. Penbutolol produces a less negative chronotropic effect as compared to propranolol. The excess of penbutolol therapeutic dose leads to the further augmentation of a positive clinical effect.
mesh_terms: D000328:Adult; D000368:Aged; D004341:Drug Evaluation; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010394:Penbutolol / Q000627:therapeutic use*; D011412:Propanolamines / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use; D011897:Random Allocation
chemical_list: D011412:Propanolamines; D010394:Penbutolol; D011433:Propranolol
vernacular_title: Vliianie penbutolla na gemodinamiku bol'nykh gipertonicheskoĭ bolezn'iu.