4,5-Disubstituted primaquine analogues as potential antimalarial agents.
Three 4,5-disubstituted primaquine analogues were synthesized and evaluated for radical curative activity against Plasmodium cynomolgi in rhesus monkeys. One of the compounds showed moderate activity; however, none of the three compounds were as active as the lead compounds 5-methoxy-4-methylprimaquine and 4-(methoxy-methyl)-5-[m-(trifluoromethyl)phenoxy]primaquine.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D008253:Macaca mulatta; D008288:Malaria / Q000188:drug therapy*; D011319:Primaquine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D011319:Primaquine