Age and thyroid hormone as factors in the responses of BHE rats to starvation-refeeding.
The interacting effects of thyroid hormone, age, and duration of starvation on the enzyme and liver lipid responses of BHE rats to starvation-refeeding were studied. Rats were starved for 2, 4, or 7 days and refed a 65% glucose diet for 2 days. The rats were either 150 or 420 days of age and injected daily with either saline or 10 micrograms thyroxine/100 g body weight. Neither age nor duration of starvation affected the glucose-6-phosphate dehydrogenase or malic enzyme activity or liver lipid response to starvation-refeeding. However, thyroxine treatment potentiated the response to starvation-refeeding in the 420-day-old rats when the duration of starvation increased from 2 to 7 days.
D000367:Age Factors; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D013217:Starvation / Q000378:metabolism*; D013974:Thyroxine / Q000494:pharmacology*; D013997:Time Factors
D008055:Lipids; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D013974:Thyroxine