[Mathematical model of activation wave propagation in an isolated cardiomyocyte].
In order to describe spontaneous wave-like contractions of a single isolated cardiomyocyte a mathematical model is proposed, which relates this phenomenon to propagation of calcium ion concentration wave along the cell. Free diffusion of Ca2+ ions as well as their reversible binding to regulatory proteins in contractile apparatus, Ca2+ accumulation in sarcoplasmic reticulum, and Ca-induced Ca2+ release are included in the governing equations. The model agrees with some observations. It predicts also some effects which may by a subject of future experimental research.
D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D008962:Models, Theoretical; D009200:Myocardial Contraction; D009206:Myocardium / Q000166:cytology*
Matematicheskaia model' rasprostraneniia voln aktivatsii v izolirovannom kardiomiotsite.