Possible association of platelet-derived growth factor (PDGF) with the appearance of reactive astrocytes following brain injury in situ.
The association of platelet-derived growth factor (PDGF) with the appearance of reactive astrocytes following injury was investigated by using a specific antagonist of PDGF, Trapidil. The cerebral cortex of 4-week-old male rats was unilaterally injured with a 22-gauge needle. Immunohistochemical staining with antiserum to glial fibrillary acidic protein revealed that reactive astrocytes had increased in number around the wound by 2 days following the injury and had spread to the ipsilateral areas distant from the wound by 3 days. The appearance of reactive astrocytes in areas distant from the wound was dramatically suppressed by the administration of Trapidil. This finding indicates that PDGF might play a role in gliosis following injury.
D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D002452:Cell Count; D005911:Gliosis; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000502:physiology*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014192:Trapidil / Q000494:pharmacology*
D010982:Platelet-Derived Growth Factor; D011743:Pyrimidines; D014192:Trapidil