Sodium arsenite potentiates the clastogenicity and mutagenicity of DNA crosslinking agents.
To see if sodium arsenite enhances the clastogenicity and the mutagenicity of DNA crosslinking agents, Chinese hamster ovary (CHO) cells and human skin fibroblasts were exposed to cis-diamminedichloroplatinum (II) (cis-Pt(II)) or 8-methoxypsoralen (8-MOP) plus long-wave ultraviolet light (UVA) and then to sodium arsenite. The results indicate that the clastogenicity of cis-Pt(II) and 8-MOP plus UVA are enhanced by the post-treatment with sodium arsenite. Chromatid breaks and exchanges are predominantly increased in doubly treated cells. Furthermore, the mutagenicity of cis-Pt(II) at the hypoxanthine-guanine phosphoribosyl transferase locus is also potentiated by sodium arsenite in CHO cells.
D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D018053:Arsenites; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects*; D002945:Cisplatin / Q000633:toxicity; D003043:Cocarcinogenesis; D006224:Cricetinae; D003412:Cricetulus; D003432:Cross-Linking Reagents / Q000633:toxicity*; D004247:DNA / Q000032:analysis*; D004357:Drug Synergism; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D008730:Methoxsalen / Q000633:toxicity; D009153:Mutagens; D009154:Mutation; D010053:Ovary; D017670:Sodium Compounds
D018053:Arsenites; D003432:Cross-Linking Reagents; D009153:Mutagens; D017670:Sodium Compounds; C017947:sodium arsenite; D004247:DNA; D001151:Arsenic; D002945:Cisplatin; D008730:Methoxsalen