[Effect of diazepam and phenobarbital on the acute toxicity of bicyclic organophosphorus esters].
Bicyclic phosphorus esters (BCP) originating from the combustion of fire-retardant polyurethane foam containing phosphorus are highly toxic compounds and potent antagonists of GABA-ergic receptors. The clinical symptoms of the poisoning are grand mal seizures. The results of experiments on rats demonstrated that diazepam and phenobarbital reduce acute toxicity of the isopropyl-BCP-derivative and remarkably smooth poisoning symptoms.
D000208:Acute Disease; D000818:Animals; D003975:Diazepam / Q000627:therapeutic use*; D004952:Esters; D008297:Male; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010634:Phenobarbital / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
D004952:Esters; D009943:Organophosphorus Compounds; D003975:Diazepam; D010634:Phenobarbital
Wpływ diazepamu i fenobarbitalu na ostra toksyczność bicyklicznych estrów fosforoorganicznych.