[Prevention of intravascular blood coagulation in rats by DIP-alpha-thrombin administration].
The possibility of prevention of intravascular blood coagulation in rats by DIP-alpha-thrombin devoid of proteolytic activity and capable of stimulating the reaction of anticoagulation system was studied. The injection of lethal thromboplastin dose was shown to produce a sharp increase in soluble fibrin blood content, total disappearance of fibrinolytic activity and intravascular blood coagulation. The animals died of thrombosis in 90% of cases. It was established that the injection of lethal thromboplastin dose 5 min after DIP-alpha-thrombin injection caused a 13% lethality from thrombosis. No reliable changes in fibrinolytic activity and soluble fibrin content were observed. A significant increase in thrombin and recalcification time was recorded. It is suggested that DIP-alpha-thrombin prevents intravascular blood coagulation induced by lethal thromboplastin dose due to mobilization of the reserve capacities of neuro-humoral anticoagulation system.
D000818:Animals; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051381:Rats; D013917:Thrombin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013925:Thromboplastin
D013925:Thromboplastin; D013917:Thrombin; C027962:diisopropylphosphoryl-thrombin
Preduprezhdenie vnutrisosudstogo svertyvaniia krovi u krys vvedeniem DIF-alpha-trombina.