[Synthesis of N-alpha-(tosylglycylprolyl)-4-amidinophenylalanine amides as thrombin inhibitors].
N alpha-(Tosylprolylglycyl)-4-cyanphenylalanine was synthesized by the reaction of an activated ester and a mixed anhydride, respectively, of Tos-Pro-Gly-OH with 4-cyanophenylalanine. N alpha-(Tosylglycylprolyl)-4-cyanophenylalanine was prepared by reaction of Tos-Gly-Cl with N alpha-prolyl-4-cyanophenylalanine. These acids were transferred into the amides. The cyano compounds were converted into the desired amidines via the thioamides and the thioimidic esters.
D000578:Amidines / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D013917:Thrombin / Q000037:antagonists & inhibitors*; D014105:Tosyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D000578:Amidines; D009842:Oligopeptides; D014105:Tosyl Compounds; D013917:Thrombin
Synthese von N alpha-(Tosylprolylglycyl)-und N alpha-(Tosylglycylprolyl)-4-amidinophenylalaninamiden als Thrombininhibitoren.