Anorectic effect of metformin in lean and genetically obese hyperglycaemic (ob/ob) mice.
To investigate the effect of metformin (dimethylbiguanide) on food intake, lean and genetically obese hyperglycaemic (ob/ob) mice habituated to a restricted feeding schedule of 3.5 hr daily, received intraperitoneal (i.p.) injections of the drug 15 min before feeding. Fifty mg/kg metformin i.p. did not significantly alter food intake. However, 250 mg/kg metformin i.p. produced a transient anorectic effect in lean mice at 30-60 min, and a more rapid and more protracted anorectic effect in obese mice. Administration of metformin (50 and 250 mg/kg/day) in the drinking water for 15 days did not significantly alter daily food intake in lean and obese mice. The results indicate a mild and transient anorectic effect of a large parenteral dose of metformin in lean and obese mice.
D000818:Animals; D001067:Appetite Depressants; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008687:Metformin / Q000494:pharmacology*; D051379:Mice; D008820:Mice, Obese
D001067:Appetite Depressants; D001786:Blood Glucose; D008687:Metformin