Brain choline acetyltransferase activity and neuropeptide Y concentrations in Alzheimer's disease.
Choline acetyltransferase (ChAT) activity and neuropeptide Y (NPY) levels in post-mortem tissues from patients with histologically proven Alzheimer's disease were compared with age-matched neurologically normal control individuals. Despite the high NPY concentrations in human cerebral cortex, no significant abnormalities were found. However, ChAT activity was reduced throughout the cortex, without a relationship to areas of functional deficit, as previously identified using fluorodeoxyglucose. These results lend further support to the concept of Alzheimer's disease as a highly selective neurodegenerative disorder.
D000544:Alzheimer Disease / Q000201:enzymology* / Q000378:metabolism; D002540:Cerebral Cortex / Q000201:enzymology* / Q000378:metabolism; D002795:Choline O-Acetyltransferase / Q000032:analysis*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009478:Neuropeptide Y; D011863:Radioimmunoassay
D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D002795:Choline O-Acetyltransferase