[Results of the clinical assessment of the pancreotropic properties of pharmacological preparations based on the pancreozymin test].
Altogether 259 tests with intravenous injection of pancreozymin (0.5 Units/kg) were made with and without administering the drugs. It was discovered that isadrin, dopamine, complamin, calcium gluconate, euphylline and papaverine stimulated the pancreatic secretion of lipase and trypsin. It was also found that atropine, the beta-adrenoreceptor blocker propranolol and corinfar, a calcium antagonist, consistently inhibited the pancreatic secretion of the enzymes. All those drugs did not favour the escape of the pancreatic enzymes to the blood according to the criterion of trypsinemia. Administration of prednisolone in a single dose or in courses enhanced the pancreatic secretion of the enzymes, while the increased trypsinemia was only noticed in solitary cases. All the data obtained during studies of the pancreotropic properties of the drugs administered in single doses or in courses are discussed from the stand-point of the clinical significance of the findings.
D002766:Cholecystokinin; D006801:Humans; D008049:Lipase / Q000097:blood; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D014357:Trypsin / Q000097:blood
D002766:Cholecystokinin; D008049:Lipase; D014357:Trypsin
Rezul'taty klinicheskoĭ otsenki pankreotropnykh svoĭstv farmakologicheskikh preparatov na osnove fonovoĭ pankreoziminovoĭ proby.