Effect of systemic estrogen on seizure susceptibility in the immature animal.
Estrogens have previously been reported to be proconvulsants in adult animals. This study evaluated the effects of acute, high-dose estrogen administration on rate of kindling in immature rats. No significant differences in rate of kindling between the estrogen-treated rats and controls were noted. This study, using the kindling model, demonstrates that estradiol does not have a significant effect on the development of seizures in the immature animal.
D000818:Animals; D004198:Disease Susceptibility; D004958:Estradiol / Q000031:analogs & derivatives / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats; D012640:Seizures / Q000139:chemically induced*
D004967:Estrogens; D004958:Estradiol