Abnormalities of dendritic actin organization in the brindled mouse.
The brindled mouse is an X-linked mutant with alterations in copper homeostasis. Ultrastructural analysis of the cerebellum and neocortex reveals several dendritic abnormalities, including the formation of Hirano bodies and other cytoskeletal alterations. Immunocytochemical evidence demonstrates that actin is a component of these microfilament lattices.
D000199:Actins / Q000032:analysis*; D000818:Animals; D002531:Cerebellum / Q000648:ultrastructure*; D002540:Cerebral Cortex / Q000648:ultrastructure*; D003433:Crosses, Genetic; D003712:Dendrites / Q000648:ultrastructure*; D005260:Female; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000033:anatomy & histology*; D008854:Microscopy, Electron
D000199:Actins