Effect of dietary protein on vitamin E levels in erythrocytes and tissues of rats.
The effect of dietary protein level on the transfer of alpha-tocopherol in blood to tissues including RBC was studied using rats. The first experiment comprised a 10% casein (low protein), 20% casein (normal) and 20% SPI (normal soybean protein) diet groups supplemented with 71.5 mg of alpha-Toc/kg diet. In Exp. 2 the relationship of the tissue alpha-Toc level and protein level in diets, as shown by recovery from vitamin E-deficient status after the administration of alpha-Toc for 3 days, was checked by adjusting the protein level in diets to 10%, 20% and 40% casein. In Exp. 1 alpha-Toc in RBC decreased significantly in the 10% casein and 20% SPI groups compared to the 20% casein group. Moreover, alpha-Toc in kidney, lung and muscle decreased significantly in the 10% casein and 20% SPI groups. alpha-Toc in liver in the 20% SPI group decreased significantly compared to the 20% casein group. In Exp. 2 similar results were observed (Table 4), but alpha-Toc in RBC showed only a tendency to decrease with the low protein diet. In Exp. 1 free cholesterol in RBC increased significantly in the 10% casein group compared with the other two groups.
D000818:Animals; D002364:Caseins / Q000008:administration & dosage / Q000494:pharmacology; D004044:Dietary Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D014674:Plant Proteins, Dietary / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D030262:Soybean Proteins; D014810:Vitamin E / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D014811:Vitamin E Deficiency / Q000188:drug therapy / Q000378:metabolism*
D002364:Caseins; D004044:Dietary Proteins; D014674:Plant Proteins, Dietary; D030262:Soybean Proteins; D014810:Vitamin E