Characterization of a novel prepro VIP derived peptide.
A newly identified, large molecular weight form of peptide histidine methionine (PHM), has been found not only where it was first revealed, in the stomach, but also in high concentrations in the nasal mucosa and urogenital system, though not in the central nervous system, intestine and lung. An antibody to the spacer peptide sequence prepro-VIP 111-122, lying between PHM and VIP, also reacts directly with the large molecular form of PHM. It is suggested that the post-translational processing of prepro-VIP differs between tissues and in some, cleavage may not occur at the C-terminal end of PHM. The biological significance of this is currently unclear.
D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006168:Guinea Pigs; D006801:Humans; D007106:Immune Sera; D009297:Nasal Mucosa / Q000032:analysis; D010446:Peptide Fragments / Q000032:analysis*; D010451:Peptide PHI / Q000032:analysis*; D011498:Protein Precursors / Q000032:analysis*; D011863:Radioimmunoassay; D051381:Rats; D013270:Stomach / Q000032:analysis; D013552:Swine; D014018:Tissue Distribution; D014566:Urogenital System / Q000032:analysis; D014660:Vasoactive Intestinal Peptide / Q000032:analysis*
D007106:Immune Sera; D010446:Peptide Fragments; D010451:Peptide PHI; D011498:Protein Precursors; C050123:preprovasoactive intestinal peptide (111-122); D014660:Vasoactive Intestinal Peptide