Effects of development, aging, and renal and hepatic insufficiency as well as hemodialysis on the plasma concentrations of albumin and alpha 1-acid glycoprotein: implications for binding of drugs.
The concentrations of total proteins, albumin, alpha 1-acid glycoprotein (AGP), and nonesterified fatty acids (NEFA) were measured in the serum of 21 newborn infants and 13 children, aged 1-13 months, and in the plasma of 31 volunteers, 25 patients with renal failure, 27 patients with cirrhosis, 39 uremic patients undergoing hemodialysis, and 20 elderly subjects. The concentration of albumin in the volunteers was higher than in all other groups. The concentration of AGP in the volunteers was higher than in newborn infants but lower than in elderly subjects, patients with renal failure, and those with chronic uremia. The concentration of NEFA in volunteers was higher than in newborn infants and patients with renal failure and lower than in elderly subjects and patients with cirrhosis.
D000367:Age Factors; D000368:Aged; D003404:Creatinine / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D009961:Orosomucoid / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000378:metabolism; D011485:Protein Binding; D006435:Renal Dialysis; D012709:Serum Albumin / Q000378:metabolism*; D014511:Uremia / Q000378:metabolism / Q000628:therapy
D005230:Fatty Acids, Nonesterified; D009961:Orosomucoid; D004364:Pharmaceutical Preparations; D012709:Serum Albumin; D003404:Creatinine