[Clinical pharmacokinetics and hemodynamics of ethacizin in the acute period of myocardial infarct].
Clinical pharmacokinetics of ethacizine and its effect on parameters of the central and peripheral hemodynamics in the acute period of myocardial infarction were studied. The appearance of an additional maximum or "concentration plateau" on the concentration-time curve following a single intravenous injection of the drug was noted in most cases. To describe experimental data, a three-compartment model with lag time was proposed. The pharmacokinetic parameters obtained indicate that ethacizine is characterized by a less value of clearance and greater period of half-elimination as compared to ethmozine. Ethacizine was shown to exert no considerable effect on hemodynamics that makes it possible to recommend its use in acute myocardial infarction when cardiac rhythm disorders occur.
D000368:Aged; D000465:Algorithms; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D016293:Moricizine / Q000031:analogs & derivatives*; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D010640:Phenothiazines / Q000008:administration & dosage / Q000097:blood*; D012984:Software; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; C027240:diethylamino-ethmozine; D016293:Moricizine
Klinicheskaia farmakokinetika i gemodinamika étatsizina v ostrom periode infarkta miokarda.