[Transitory pseudohypoparathyroidism in the newborn infant].
This is a report on two young infants suffering from transitory pseudohypoparathyroidism. Therapy with vitamin D in high doses was not helpful but metabolic changes were promptly corrected by the administration of 1.25-(OH)2-D3 (Rocaltrol). The typical pretreatment findings were: hypocalcemia, hyperphosphatemia, reduced clearance of phosphate. Parathormone in serum was normal. Treatment with 0.25 and 0.5 micro-Gram 1.25-(OH)2-D3 respectively resulted in prompt correction of serum calcium- and serum-phosphate-changes. The observation of the urinary-cAMP-excretion during the course of the disease enables one to differentiate between the permanent and the transient form of the disease: values reaching 5-10 nmol/mg Creatinine indicate the time when treatment can be discontinued in the transitory form.
D002117:Calcitriol / Q000627:therapeutic use; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008274:Magnesium / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D011547:Pseudohypoparathyroidism / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy
D010281:Parathyroid Hormone; D010710:Phosphates; D002117:Calcitriol; D008274:Magnesium; D002118:Calcium
Transitorischer Pseudohypoparathyreoidismus beim Neugeborenen.