title: [Effect of thyroid hormones on lipogenic liver enzymes in relation to age].
abstract: The influence of the thyrohormone status and of a nutrition rich in cholesterol on the hepatic enzymes glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, malate enzyme, and citrate cleavage enzyme was examined in female Wistar rats aged 3 and 18 months. Contrary to the findings in young animals, hyperthyreosis does not cause any significant increase in the activities of the malate enzyme and of the citrate cleavage enzyme. A nutrition rich in cholesterol induces a decrease of the activity of the malate enzyme in 3-month old rats; not, however, in the old rats.
mesh_terms: D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D000375:Aging; D000818:Animals; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006980:Hyperthyroidism / Q000201:enzymology; D007037:Hypothyroidism / Q000201:enzymology; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000201:enzymology*; D008291:Malate Dehydrogenase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013963:Thyroid Hormones / Q000502:physiology*
chemical_list: D002791:Cholesterol, Dietary; D008055:Lipids; D013963:Thyroid Hormones; D002784:Cholesterol; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D001275:ATP Citrate (pro-S)-Lyase
vernacular_title: Einfluss von Thyreohormonen auf lipogene Leberenzyme in Abhängigkeit vom Lebensalter.