[Thromboxane and prostacyclin in patients with stenocardia in induced and spontaneous ischemia of the myocardium].
The levels of TxB2 and 6-keto-PGI alpha in the coronary sinus and thoracic aorta blood were determined in 14 patients with angina pectoris and signs of coronary atherosclerosis. 12 patients were involved in a dynamic study: before, during and 10 minutes after ischaemia-inducing atrial pacing. In all the patients atrial pacing resulted in a typical episode of angina, in 7 of them ST-segment depression of not less than 2 mm was seen on the ECG. In one patient arachidonic acid metabolites were evaluated during the control period and during a spontaneous episode of angina accompanied by ST-segment elevations. In 8 of 9 patients TxB2 was produced by the myocardium during atrial pacing. During monitored evaluation of arachidonic acid metabolites one patient with spontaneous angina demonstrated a gradual lowering of the 6-keto-PGI alpha, it being minimal by the beginning of the episode; TxB2 level increased more rapidly.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000328:Adult; D000787:Angina Pectoris / Q000097:blood*; D003327:Coronary Disease / Q000097:blood* / Q000209:etiology; D004558:Electric Stimulation; D006325:Heart Atria; D006801:Humans; D008297:Male; D008875:Middle Aged; D013929:Thromboxane B2 / Q000097:blood*
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha
Tromboksan i prostatsiklin u bol'nykh stenokardieĭ pri indutsirovannoĭ i spontannoĭ ishemii miokarda.