Intensely potent anthracycline antibiotic oxaunomycin produced by a blocked mutant of the daunorubicin-producing microorganism.
A new potent anthracycline antibiotic oxaunomycin was isolated from the culture broth of a blocked mutant derived from a baumycin producer and was identified as 7-O-(alpha-L-daunosaminyl)-beta-rhodomycinone. It exhibited about 100 times more strongly cytotoxic activity against leukemic L1210 cell culture than doxorubicin.
D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003630:Daunorubicin / Q000096:biosynthesis*; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D009154:Mutation; D009279:Naphthacenes / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; C049973:oxaunomycin; D003630:Daunorubicin