[Cytochrome P-450-dependent reactions during intensified biosynthesis of coenzyme A in hepatocytes].
After subcutaneous administration into male rats of 4-phosphopantothenic acid and pantethine during 10 days at a dose equivalent to 30 mg/kg of calcium pantothenate total content of CoA was increased in liver tissue. Both these preparations activated the liver endoplasmic reticulum monooxygenase system mainly at the step of substrate hydroxylation. The phenomenon observed appears to occur due to activation of cytochrome P-450 biosynthesis and/or to alterations in phospholipid composition of microsomal membranes.
D000818:Animals; D003065:Coenzyme A / Q000096:biosynthesis*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology; D010204:Pantetheine / Q000031:analogs & derivatives / Q000494:pharmacology; D010205:Pantothenic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats
D008054:Lipid Peroxides; D008563:Membrane Lipids; D010205:Pantothenic Acid; C011988:phosphopantothenic acid; D010204:Pantetheine; C005425:pantethine; D003577:Cytochrome P-450 Enzyme System; D003065:Coenzyme A
Tsitokhrom P-450-zavisimye reaktsii v usloviiakh intensifikatsii biosinteza kofermenta A v gepatotsitakh.