[Modification of intracranial pressure by urapidil following experimental cold lesions in the cat].
The action of the antihypertensive agent Urapidil was investigated in an experimental animal model of vasogenic brain oedema. Animals with normal or raised intracranial pressure received Urapidil as a bolus injection (0.25 mg/kg body weight) followed by a continuous infusion of Urapidil (1 mg/kg body weight). The bolus injection of the drug was followed by a sharp fall in systemic blood pressure, paralleled by a rise in intracranial pressure, resulting in a shortlasting decline of cerebral perfusion pressure. During continuous infusion of Urapidil in both groups with normal or elevated ICP there was a long-lasting significant fall in the systemic blood pressure without any significant alteration of the intracranial pressure.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001929:Brain Edema / Q000503:physiopathology*; D001930:Brain Injuries / Q000503:physiopathology; D002415:Cats; D005260:Female; D005615:Freezing; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*
D000959:Antihypertensive Agents; D010879:Piperazines; C015568:urapidil
Zur Beeinflussung des intrakraniellen Druckes unter Urapidil nach experimenteller Kälteläsion bei der Katze.