Auditory aspects of seizure in the genetically epilepsy prone rat.
The organ of Corti of Genetically Epilepsy Prone Rats was examined anatomically and electrophysiologically using scanning electron microscopy (SEM) and electrophysiological recording of alternating current cochlear potentials (ACCP) and N1, a volume conductor recording of the primary auditory afferent action potentials. ACCPs for GEPRs with low intensity seizures (Acoustic Response Score (ARS) = 2 or 3) and high intensity seizures (ARS = 9) showed similar impairment in cochlear function. Approximately a 25-35 dB shift in input-output functions was present in GEPRs as compared to controls. SEM revealed several types of possible genetic abnormalities which explain the deficits in cochlear function and could serve as the basis for seizure predisposition in these animals.
D000161:Acoustic Stimulation; D000818:Animals; D003051:Cochlea / Q000002:abnormalities / Q000473:pathology / Q000503:physiopathology* / Q000648:ultrastructure; D004594:Electrophysiology; D006198:Hair Cells, Auditory / Q000503:physiopathology / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D009925:Organ of Corti / Q000473:pathology / Q000503:physiopathology; D010033:Otitis Media / Q000503:physiopathology; D051381:Rats; D011922:Rats, Mutant Strains / Q000502:physiology*; D012640:Seizures / Q000473:pathology / Q000503:physiopathology*