title: The number of families required to detect or exclude linkage heterogeneity.
abstract: Under the assumption of two family types, one with linkage and one without linkage, the number of phase-known double-backcross families required to detect heterogeneity is investigated. The case of testing for heterogeneity with two offspring per family is shown to be formally equivalent to testing for inbreeding effects in a sample of unrelated individuals.
mesh_terms: D008040:Genetic Linkage; D005826:Genetics, Medical / Q000379:methods*; D006801:Humans; D010375:Pedigree; D011336:Probability; D011995:Recombination, Genetic