title: [Cloning and the determination of the nucleotide sequences in 2 genes of human leukocyte interferons].
abstract: Four different recombinant phages carrying interferon sequences were identified in the human gene bank on vector Charon 4A. A fragment of interferon A gene cloned previously through cDNA was used as a hybridization probe for analysis of the bank. The nucleotide sequence of DNA encoding the interferon genes was determined for 2 recombinant phages. One of these genes corresponded to the interferon A gene but one amino acid substitution (His 34-Arg). The second gene (I1) belonged to the family of the interferon C genes and differed from all the genes described earlier.
mesh_terms: D001435:Bacteriophages / Q000235:genetics; D001483:Base Sequence; D003001:Cloning, Molecular / Q000379:methods*; D004247:DNA / Q000235:genetics; D005796:Genes; D005822:Genetic Vectors; D006801:Humans; D007370:Interferon Type I / Q000235:genetics*; D009693:Nucleic Acid Hybridization
chemical_list: D007370:Interferon Type I; D004247:DNA
vernacular_title: Klonirovanie i opredelenie nukleotidnykh posledovatel'nosteĭ dvukh genov leĭkotsitarnykh interferonov cheloveka.