title: The immune response during proliferative kidney disease in rainbow trout: a case history.
abstract: Young-of-the-year rainbow trout clinically affected by proliferative kidney disease (PKD), a systemic protozoan infection, exhibit a massive proliferation of small lymphocytes in the posterior kidney and spleen, a decrease in erythrocyte packed cell volume, hemoglobin, and serum albumins and an increase in beta-globulins. Electronphotomicrographs of the causative agent indicate that it is engulfed within a macrophage which is surrounded by small lymphocytes. Fish having survived a clinical episode are completely refractory to subsequent infection. Their serum electrophoretic patterns are quite unremarkable.
mesh_terms: D000818:Animals; D005393:Fish Diseases / Q000276:immunology* / Q000469:parasitology; D007674:Kidney Diseases / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D011528:Protozoan Infections / Q000276:immunology; D011529:Protozoan Infections, Animal; D012487:Salmonidae / Q000276:immunology*; D014337:Trout / Q000276:immunology*