title: Contrast adaptation in cat visual cortex is not mediated by GABA.
abstract: The possible involvement of gamma-aminobutyric acid (GABA) in contrast adaptation in single cells in area 17 of the cat was investigated. Iontophoretic application of N-methyl bicuculline increased cell responses, but had no effect on the magnitude of adaptation. These results suggest that contrast adaptation is the result of inhibition through a parallel pathway, but that GABA does not mediate this process.
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001640:Bicuculline / Q000031:analogs & derivatives / Q000494:pharmacology; D002415:Cats; D009433:Neural Inhibition; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D005680:gamma-Aminobutyric Acid; C006749:bicuculline methochloride; D001640:Bicuculline