Cultivation of Rhinosporidium seeberi in vitro: interaction with epithelial cells.
Rhinosporidium seeberi, a fungus that is associated with polyp-like tumors in animals and man, was successfully cultivated. This organism stimulated proliferation of epithelial cells in vitro, producing polyp-like structures. Spores produced in culture required a period of aging or development, or both, before they were capable of reinitiating the growth cycle.
D000818:Animals; D002453:Cell Cycle; D002478:Cells, Cultured; D004285:Dogs; D004848:Epithelium / Q000382:microbiology; D006801:Humans; D011127:Polyps / Q000382:microbiology; D012228:Rhinosporidium / Q000254:growth & development*