[The influence of ileo-jejunal transposition on intestinal mucosal growth and gut hormones after total colectomy].
To clarify the effect of ileo-jejunal transposition on intestinal mucosal height and gut hormones, canine models undergoing total colectomy either with transection of the small intestine (control group) or ileo-jejunal transposition (transposition group) were compared, and the following results were obtained. There was no difference in body weight between control group and transposition group 18 weeks after operation. Significant increase of mucosal height was observed in transposition group but not in control group. Plasma levels of total GLI were significantly higher in transposition group but not in control group, whereas a count of GLI secreting cell was not changed in both groups. Plasma levels of gastrin after test meal were lower in transposition group than in control group. These results indicated that ileo-jejunal transposition induces hyperenteroglucagonemia, which may play an important role in intestinal adaptation after colectomy.
D000222:Adaptation, Physiological; D000818:Animals; D003106:Colon / Q000601:surgery*; D004285:Dogs; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D004763:Glucagon-Like Peptides / Q000378:metabolism*; D007082:Ileum / Q000601:surgery*; D007413:Intestinal Mucosa / Q000502:physiology*; D007583:Jejunum / Q000601:surgery*
D005768:Gastrointestinal Hormones; D004763:Glucagon-Like Peptides