Immunohistochemical properties of the "floor plate glycogen body" of the human embryonic spinal cord and brain stem.
Prominent glycogen accumulations have been found in the floor plate radial glial cells of the human spinal cord and brain stem during the 6th to 13th week of intrauterine life. These glycogen-rich cells are totally negative to indirect immunoperoxidase staining with an antibody to glial fibrillary acidic protein, a protein that is strongly expressed in the remaining radial glial cells that border the central canal of the spinal cord. The glycogen-rich floor plate radial glial cells are, on the other hand, heavily stained by a monoclonal antibody against a vimentin-related protein. The neighbouring lateral radial glial cells do not express this protein. These and other distinctive features of the floor plate radial glial cells indicate an organoid specialisation of the floor plate during limited periods of intrauterine life. The function(s) of this specialised tissue remains obscure, but it may be related to cortico-spinal fibres crossing the midline through the floor plate, or to the transport of substances in both directions between blood vessels and the central canal.
D001933:Brain Stem / Q000033:anatomy & histology / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000033:anatomy & histology / Q000378:metabolism*; D005865:Gestational Age; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D008854:Microscopy, Electron; D013116:Spinal Cord / Q000033:anatomy & histology / Q000378:metabolism*; D014018:Tissue Distribution; D014746:Vimentin / Q000378:metabolism
D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin; D006003:Glycogen