Pharmacokinetic interactions of cyclophosphamide and 5-fluorouracil with methotrexate in an animal model.
In tumor-bearing WAG/Rij rats the interaction of cyclophosphamide and/or 5-fluorouracil (5-FU) with methotrexate as manifested at the pharmacokinetic level was studied. Four groups were formed of at least ten animals. The control group, which received single-agent methotrexate, was compared with groups that received methotrexate plus cyclophosphamide, methotrexate plus 5-FU, and methotrexate plus cyclophosphamide plus 5-FU. There appeared to be an increase of 40% in the clearance of methotrexate by the triple combination. Cyclophosphamide especially diminished the terminal part of the concentration-time curve of methotrexate.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000378:metabolism* / Q000627:therapeutic use; D001800:Blood Specimen Collection; D003520:Cyclophosphamide / Q000008:administration & dosage; D004347:Drug Interactions; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006207:Half-Life; D007700:Kinetics; D008727:Methotrexate / Q000008:administration & dosage / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000188:drug therapy; D051381:Rats; D013223:Statistics as Topic
D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate