Isolation and properties of valanimycin, a new azoxy antibiotic.
Valanimycin, a new azoxy antibiotic, was isolated from culture broths of a streptomycete. Valanimycin is an unstable oil at room temperature and active against some Gram-positive and Gram-negative bacteria, mouse leukemia L1210 cells in cultures, and prolongs the life span of mice inoculated with Ehrlich carcinoma or L1210.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001391:Azo Compounds / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D013302:Streptomyces / Q000145:classification / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D001391:Azo Compounds; C048267:valanimycin