title: Comparative cytotoxicity of four nickel compounds to canine and rodent alveolar macrophages in vitro.
abstract: Nickel subsulfide (Ni3S2), nickel sulfate (NiSO4), nickel chloride (NiCl2), and nickel oxide (NiO), are four compounds encountered by workers in the nickel-refining and electroplating industries. These compounds were tested for their relative toxicity to beagle dog and F344/Crl rat alveolar macrophages in vitro. Dog alveolar macrophages were at least 10 times more sensitive to the effects of each of the 4 nickel compounds than were rat alveolar macrophages. Toxicity ranking of the four nickel compounds to macrophages from both species was Ni3S2 greater than NiCl2 approximately NiSO4 greater than NiO.
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D009532:Nickel / Q000633:toxicity*; D011650:Pulmonary Alveoli / Q000187:drug effects*; D051381:Rats; D012995:Solubility; D013045:Species Specificity
chemical_list: D009532:Nickel