[Pharmacological blockade of the nephrotoxicity of cisplatin in rats].
Cisplatin injection (0.5 mg/100 g body weight) induced 5 days later an increase in serum urea concentration from 3.31 +/- 0.67 to 47.1 +/- 8.68 mg/ml and diuresis decrease following water loading test. Ethacrynic acid, furosemide, paraaminohippurate pre-injections prevented cisplatin nephrotoxicity. The decrease in cisplatin nephrotoxicity took place when furosemide was administered before or 3 h after cisplatin injection; 6 h after cisplatin injection furosemide was not effective. The results suggest that pharmacological blockade of cisplatin nephrotoxicity depends on the drug penetration into secreting cells of proximal tubules.
D000818:Animals; D002945:Cisplatin / Q000037:antagonists & inhibitors* / Q000633:toxicity; D004347:Drug Interactions; D004573:Electrolytes / Q000378:metabolism; D004976:Ethacrynic Acid / Q000494:pharmacology; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D013997:Time Factors; D014508:Urea / Q000378:metabolism; D010130:p-Aminohippuric Acid / Q000494:pharmacology
D004573:Electrolytes; D005665:Furosemide; D014508:Urea; D004976:Ethacrynic Acid; D002945:Cisplatin; D010130:p-Aminohippuric Acid
Farmokologicheskaia blokada nefrotoksichnosti tsis-platiny u krys.