The helical hydrophobic moment avoids prolines in phospholipid-binding proteins.
Proline residues appear to punctuate the distribution of amphiphilic phospholipid-binding regions of apolipoproteins. We have applied a quantitative test to this hypothesis and shown that the magnitude of the helical hydrophobic moment around proline residues is reduced in lipid-binding proteins and peptides.
D000595:Amino Acid Sequence; D001053:Apolipoproteins / Q000032:analysis*; D002352:Carrier Proteins / Q000032:analysis*; D010743:Phospholipids / Q000378:metabolism*; D011392:Proline / Q000032:analysis*; D011487:Protein Conformation
D001053:Apolipoproteins; D002352:Carrier Proteins; D010743:Phospholipids; D011392:Proline