Investigation into the inhibitory effect of flurofamide on animal ureaplasmas and its use in the treatment of ureaplasma-infected sheep.
In vitro tests with the urease inhibitor flurofamide demonstrated that the final inhibitory concentration of 0.5-4 microM on the growth of nine ureaplasma strains was largely ureaplasmastatic, requiring prolonged incubation to have a ureaplasmacidal effect. Intramuscular injection of flurofamide successfully eliminated genital infections of ureaplasma in sheep only when the treatment was repeated on two consecutive days. A dose rate of 5-20 mg/kg body weight eliminated the organism from naturally infected sheep, but 15-25 mg/kg body weight was required to eliminate the infection from eleven of fourteen experimentally, newly infected sheep. Administration of the flurofamide orally in the drinking water failed to eliminate ureaplasmas from any of twenty newly infected sheep.
D000284:Administration, Oral; D000818:Animals; D001549:Benzamides / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D007273:Injections, Intramuscular; D008297:Male; D009180:Mycoplasmatales Infections / Q000188:drug therapy / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000382:microbiology; D014509:Ureaplasma / Q000302:isolation & purification*
D001549:Benzamides; C032764:flurofamide