Interaction of hemoglobin Siriraj with hemoglobin S: a mild sickle cell syndrome.
Hb Siriraj is a beta chain variant in which beta 7 (A4) Glu is replaced by a lysine. It has been encountered in association with Hb S in a black man from Martinique. Some properties of Hb Siriraj are compared, particularly, with Hb C [alpha 2 beta 26(A3)Glu----Lys], and a study of its in vitro interaction with Hb S is discussed.
D000595:Amino Acid Sequence; D000755:Anemia, Sickle Cell / Q000097:blood*; D006580:Genetic Carrier Screening; D014644:Genetic Variation; D006441:Hemoglobin A / Q000378:metabolism; D006451:Hemoglobin, Sickle / Q000378:metabolism*; D006455:Hemoglobins, Abnormal / Q000235:genetics / Q000378:metabolism*; D006461:Hemolysis; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D013577:Syndrome
D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal; D006441:Hemoglobin A; C048606:hemoglobin Siriraj