title: Terpenoid biotransformation in mammals. IV Biotransformation of (+)-longifolene, (-)-caryophyllene, (-)-caryophyllene oxide, (-)-cyclocolorenone, (+)-nootkatone, (-)-elemol, (-)-abietic acid and (+)-dehydroabietic acid in rabbits.
abstract: The metabolism of (+)-longifolene, (-)-caryophyllene, (-)-caryophyllene oxide, (-)-cyclocolorenone, (+)-nootkatone, (-)-elemol, (-)-abietic acid and (+)-dehydroabietic acid was studied in rabbits. Each of these sesquiterpenoids was converted to primary, secondary or tertiary alcohols, among which the primary alcohol was predominant. A vinylic methyl group and an exomethylene group were easily hydroxylated and converted to a glycol via an epoxide in many cases. Eight new metabolites were determined by chemical and spectroscopic methods.
mesh_terms: D045784:Abietanes; D000818:Animals; D001711:Biotransformation; D004224:Diterpenes / Q000378:metabolism*; D010616:Phenanthrenes; D000081223:Polycyclic Sesquiterpenes; D011817:Rabbits; D012717:Sesquiterpenes / Q000378:metabolism*
chemical_list: D045784:Abietanes; D004224:Diterpenes; D010616:Phenanthrenes; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C035607:longifolene; C007186:cyclocolorenone; C024714:caryophyllene; C050302:nootkatone; C033011:elemol; C023710:abietic acid