Colon cancer in the Cronkhite-Canada syndrome.
A patient with Cronkhite-Canada syndrome had multiple juvenile colonic polyps with hyperplastic, adenomatous, and mixed villous and adenomatous changes. A Dukes B mucus-secreting adenocarcinoma of the cecum was also present. Currently considered a benign disease, the Cronkhite-Canada syndrome may be a premalignant disorder, as our patient's course suggests. We review the literature in this regard.
D000230:Adenocarcinoma / Q000209:etiology* / Q000473:pathology; D003110:Colonic Neoplasms / Q000209:etiology* / Q000473:pathology; D003111:Colonic Polyps / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013577:Syndrome