Suppression of ovarian function by Microgynon 30 in day 1 and day 5 "starters".
The suppression of ovulation during the first treatment cycle with Microgynon 30 (150 micrograms levonorgestrel and 30 micrograms ethinyl oestradiol) for nine subjects starting the "pill" on day 1 of their cycle and five subjects on day 5 was investigated. Serum oestradiol and progesterone levels throughout the cycle and midcycle urinary LH levels were reliably suppressed in all day 1 "starters". Serum progesterone levels and urinary LH levels were also suppressed in day 5 "starters" but one subject produced oestradiol levels within the normal range of ovulatory cycles. Mean oestradiol levels of day 5 "starters" were found to be significantly higher than those of day 1 "starters" (p less than 0.05).
D000293:Adolescent; D000328:Adult; D003278:Contraceptives, Oral, Hormonal / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004958:Estradiol / Q000097:blood; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D006801:Humans; D008597:Menstrual Cycle; D009644:Norgestrel / Q000008:administration & dosage / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects*; D010060:Ovulation / Q000187:drug effects; D011374:Progesterone / Q000097:blood
D003278:Contraceptives, Oral, Hormonal; D009644:Norgestrel; D004997:Ethinyl Estradiol; D011374:Progesterone; D004958:Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination