[The effect on barbiturates on hemodynamics during extracorporeal circulation: thiopental versus methohexital].
We studied the effects of thiopentone (3 vs 6 mg/kg) and methohexitone (1 vs 2 mg/kg) on TPR during hypertensive episodes (m BP greater than 80 mmHg) under the conditions of ECC and hypothermia: T led to an initial shortlasting increase of TPR up to 114% and 125% from baseline for the dosages tested. This was followed by a decrease to 67% and 56% respectively. After 5 min TPR returned to control. The effect of M on TPR is less pronounced (maximum reduction of 35%) but of longer duration. In contrast to thiopentone we did not observe a biphasic course of TPR following administration of methohexitone.
D000758:Anesthesia; D001463:Barbiturates / Q000494:pharmacology*; D004569:Electroencephalography; D005112:Extracorporeal Circulation; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008723:Methohexital / Q000494:pharmacology*; D013874:Thiopental / Q000494:pharmacology*
D001463:Barbiturates; D008723:Methohexital; D013874:Thiopental
Der Einfluss von Barbituraten auf die Haemodynamik während extrakorporaler Zirkulation: Thiopental versus Methohexital.