[Cooperative effect of hydrocortisone, adrenaline and high-density lipoproteins in regulating the glucose-6-phosphate dehydrogenase activity of the liver].
The role of adaptive hormones and serum lipoproteins in the regulation of glucose-6-phosphate dehydrogenase (G-6-PDH) activity was investigated. The test was performed on experimental hepatic sections of Wistar rats. It was shown that timely regulation of G-6-PDH by epinephrine and hydrocortisone which inhibits the activity of enzyme is manifested through the cAMP-dependent mechanism. The cooperative effect of epinephrine, hydrocortisone and high-density lipoproteins that enables G-6-PDH activation was revealed. It was stated that only high-density lipoproteins of subpopulation III were capable of hormonal mediating. The effect was caused by the induction of enzyme synthesis and manifested through lysosome-dependent activation of chromatin.
D000818:Animals; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology / Q000502:physiology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology / Q000502:physiology*; D066298:In Vitro Techniques; D008075:Lipoproteins, HDL / Q000494:pharmacology / Q000502:physiology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D008075:Lipoproteins, HDL; D005954:Glucosephosphate Dehydrogenase; D006854:Hydrocortisone; D004837:Epinephrine
O kooperativnom éffekte gidrokortizona, adrenalina i lipoproteidov vysokoĭ plotnosti v reguliatsii aktivnosti gliukozo-6-fosfatdegidrogenazy v pecheni.