Computer-controlled muscle paralysis with atracurium in the sheep.
Paralysis was maintained in sheep by computer-controlled infusion of atracurium, using the integrated electromyogram as a measure of neuromuscular transmission. A number of experiments were conducted to ascertain the average infusion rate required to achieve a given level of paralysis for one hour. Each experiment yielded a point on a plot of paralysis versus infusion rate. A dose-response curve based upon a simple model of drug receptor interaction at the neuromuscular junction was fitted to the experimental points by least squares and is able to provide a useful explanation of clinically observed behaviour. The recovery time was also measured in each experiment and plotted against both prior level of paralysis and prior average infusion rate.
D000818:Animals; D001279:Atracurium; D003201:Computers; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D007546:Isoquinolines / Q000008:administration & dosage*; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage*; D012756:Sheep
D007546:Isoquinolines; D009466:Neuromuscular Blocking Agents; D001279:Atracurium