Chemically reversible electroreduction of guanine in a polynucleotide chain.
It was shown that synthetic polynucleotides containing guanine display in cyclic voltammetry (CV) an anodic peak close to -0.3 V (against a saturated calomel electrode). A condition for the appearance of this peak is the previous polarization of the mercury electrode to sufficiently negative potentials (around -1.8 V). The results of CV measurements with electrode polarization by repeated cycles indicate that in negative potentials there is a reduction of guanine residues and in the anodic process reoxidation of the reduction product to guanine. This chemically reversible process takes place even when a polynucleotide contains adenine and/or cytosine residues in addition to guanine, where reduction leads to the formation of products blocking the electrode surface.
D004247:DNA; D004563:Electrochemistry; D004566:Electrodes; D006147:Guanine; D011131:Polyribonucleotides; D011199:Potentiometry
D011131:Polyribonucleotides; D006147:Guanine; D004247:DNA