Circulating levels of insulin-like growth factors 1 and 2 and somatomedin B in alcoholic patients.
The levels of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) and somatomedin B in serum and cerebrospinal fluid (CSF) were investigated in alcoholic patients for 4 weeks after alcohol intake stopped. Throughout the observation period, CSF levels of IGF-2 were significantly decreased compared to those of healthy controls, whereas CSF levels of somatomedin B increased significantly 8 days after alcohol withdrawal and remained elevated throughout the observation period. CSF levels of IGF-2 were significantly correlated to measurements of ventricular enlargement on computed tomography. Somatomedin B levels were significantly correlated to clinical variables such as pulse, temperature, and agitation. No increase in the serum levels of somatomedin B were observed, but an increase in serum IGF levels was found in the patient group.
D000328:Adult; D000437:Alcoholism / Q000378:metabolism* / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D011869:Radioligand Assay; D013002:Somatomedins / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
D013002:Somatomedins; C016756:somatomedin B; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II