title: Changes of acid and alkaline phosphatase activities in the developing mouse brain.
abstract: Acid and alkaline phosphatase activities in the mouse cerebrum, brainstem and cerebellum increased during the late fetal and perinatal period and reached a maximum on postnatal day 28 (P28). Myelination was most extensive on P28-P45 in the brainstem and in the cerebellum, and phosphatidic acid phosphatase activity concomitantly decreased to a low level after birth. The changes in acid and alkaline phosphatase activities correlate more with the extent of myelination than with the overall brain tissue growth.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000196:embryology / Q000201:enzymology / Q000254:growth & development*; D001933:Brain Stem / Q000254:growth & development; D002531:Cerebellum / Q000254:growth & development; D005314:Embryonic and Fetal Development; D051379:Mice; D008813:Mice, Inbred ICR; D009186:Myelin Sheath / Q000502:physiology*; D013116:Spinal Cord / Q000201:enzymology
chemical_list: D000469:Alkaline Phosphatase; D000135:Acid Phosphatase