Monoclonal antibodies against the fusion protein are protective in necrotizing mumps meningoencephalitis.
A monoclonal antibody against the fusion (F) protein of mumps virus was found to confer marked protection in mumps virus-induced encephalitis. Almost total prevention of extensive brain necrosis was found. This study indicates that the virus F protein is directly involved in the pathogenesis of brain necrosis.
D000818:Animals; D000831:Animals, Newborn; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001921:Brain / Q000382:microbiology; D006224:Cricetinae; D008590:Meningoencephalitis / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D009109:Mumps virus / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology*; D014760:Viral Fusion Proteins
D000911:Antibodies, Monoclonal; D014759:Viral Envelope Proteins; D014760:Viral Fusion Proteins