title: Structure/nerve membrane effect relationships of some local anaesthetics.
abstract: Data on electron structure and octanol-water partition coefficients of certain local anaesthetics are compared with the capacity of reversibly block the action potential of the frog sciatic nerve. Some active parts in the molecules of these substances have been shown to be primarily involved in the action of local anaesthetics.
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D001566:Benzocaine / Q000494:pharmacology; D004583:Electrons; D008012:Lidocaine / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D011343:Procaine / Q000494:pharmacology; D011895:Rana ridibunda; D012584:Sciatic Nerve / Q000187:drug effects* / Q000502:physiology; D013329:Structure-Activity Relationship; D013748:Tetracaine / Q000494:pharmacology; D014867:Water / Q000502:physiology
chemical_list: D000779:Anesthetics, Local; D014867:Water; D013748:Tetracaine; D011343:Procaine; D008012:Lidocaine; D001566:Benzocaine