[Effect of 3,12-B-dimethyloctahydroindolo-(2,3-a)-quinolyzine on the alcohol predilection of laboratory animals].
It was shown that 3,12-b-dimethyl-octahydroindol-(2,3-a) quinolyzine (at the dose of 1/6 of LD50) exerted an antialcohol effect in mice and rats which is probably due to an increased content of the brain 5-hydroxytryptamine resulting from selective inhibition of its deamination.
D000428:Alcohol Drinking; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007211:Indoles / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D011807:Quinolizines; D051381:Rats; D012701:Serotonin / Q000378:metabolism
D007211:Indoles; D011807:Quinolizines; D012701:Serotonin; C049067:3,12-dimethyloctahydroindol-(2,3-a)quinolizine; D008995:Monoamine Oxidase; D009638:Norepinephrine
Vliianie 3,12-B-dimetiloktagidroindolo-(2,3-a)-khinolizina na pristrastie k alkogoliu u laboratornykh zhivotnykh.