title: [Pharmacokinetics and the clinical effect of bemitil after a single administration].
abstract: It was found on studying a novel psychotropic drug bemitil that after its single administration kinetic curves significantly differed depending on a clinical effect of the test dose in patients with asthenic states. At predomination of the psychoactivating component of action one could note a larger area under the concentration-time relationship curve and a shorter period of half-excretion than in patients with the tranquilizing action. The obtained data on the difference in the drug test dose effect depending on the drug pharmacokinetics should be taken into consideration at determination of bemitil course therapy duration in patients with neuroses and neurosis-like states with predominance of asthenic disturbances in the clinical picture.
mesh_terms: D000328:Adult; D001562:Benzimidazoles / Q000097:blood* / Q000627:therapeutic use; D002849:Chromatography, Gas; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009440:Neurasthenia / Q000097:blood / Q000188:drug therapy; D009497:Neurotic Disorders / Q000097:blood / Q000188:drug therapy; D011619:Psychotropic Drugs / Q000097:blood* / Q000627:therapeutic use
chemical_list: D001562:Benzimidazoles; D011619:Psychotropic Drugs; C049825:bemethyl
vernacular_title: Farmakokinetika i klinicheskiĭ éffekt bemitila posle odnokratnogo primeneniia.