Weber-Christian panniculitis and chronic active hepatitis.
We report a 4-year-old child with Weber-Christian panniculitis who subsequently developed histologically proven chronic active hepatitis, pancreatitis and extensive lipoatrophy. An "LKM" variant autoantibody was detected in the serum and a favourable response has been seen with immunosuppressive therapy. These findings lend support to the concept of Weber-Christian being an "auto-immune" disease.
D001323:Autoantibodies / Q000032:analysis; D002675:Child, Preschool; D006521:Hepatitis, Chronic / Q000150:complications*; D006801:Humans; D007668:Kidney / Q000276:immunology; D008060:Lipodystrophy / Q000150:complications; D008099:Liver / Q000276:immunology; D008297:Male; D008861:Microsomes / Q000276:immunology; D010195:Pancreatitis / Q000150:complications; D010201:Panniculitis, Nodular Nonsuppurative / Q000150:complications* / Q000276:immunology
D001323:Autoantibodies