title: Immunohistochemical evidence of plasticity of gamma-aminobutyric acid neurons in the red nucleus and adjacent reticular formation after contralateral cerebellectomy in the adult cat.
abstract: A comparative mapping of gamma-aminobutyric acid neurons identified by means of glutamic acid decarboxylase (GAD) immunohistochemistry was performed in the red nucleus (RN) in both intact and hemicerebellectomized adult cats (21 days postoperative). In the deafferented RN (contralateral to the lesion) as well as in the adjacent dorsolateral reticular formation, a marked increase in the number of GAD-positive perikarya was observed. In this mesencephalic area, some neurons may therefore increase their endogenous levels of immunodetectable GAD, as a response to cerebellar deafferentation. This can be viewed as one of the events contributing to functional recovery.
mesh_terms: D000818:Animals; D002415:Cats; D002531:Cerebellum / Q000293:injuries / Q000502:physiology*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D008636:Mesencephalon / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009473:Neuronal Plasticity; D012012:Red Nucleus / Q000201:enzymology / Q000502:physiology*; D012154:Reticular Formation / Q000201:enzymology / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase