Effects of CCNU on monocyte phagocytosis.
The effect of CCNU on human monocyte phagocytosis of yeast cells was measured in vitro. 'Therapeutic' CCNU concentrations had no measurable effect on monocyte phagocytosis. Higher concentrations of CCNU had a slight but statistically significant effect on the engulfment phase of monocyte phagocytosis. The results suggest that CCNU treatment is of minor importance for monocyte function.
D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008130:Lomustine / Q000494:pharmacology*; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*
D008130:Lomustine