title: Influence of topical beclomethasone dipropionate suspension on human nasal mucociliary activity.
abstract: The local effect of an aqueous suspension of beclomethasone dipropionate on human nasal mucociliary clearance was studied in 14 healthy volunteers. A triple blind, randomized, placebo controlled, cross-over design was utilised. Measurements of mucociliary clearance were made before treatment, after a single dose and after one week of continuous treatment either with placebo or active substance, utilising the saccharine-dye test. No change in mucociliary clearance was found after treatment with beclomethasone dipropionate or placebo suspension.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D001507:Beclomethasone / Q000008:administration & dosage / Q000494:pharmacology*; D002923:Cilia / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects*; D011897:Random Allocation; D013535:Suspensions
chemical_list: D013535:Suspensions; D001507:Beclomethasone