Actinopyrones A, B and C, new physiologically active substances. I. Producing organism, fermentation, isolation and biological properties.
A strain of Streptomyces was found to produce new physiologically active substances. The active compounds were purified and separated into three substances named actinopyrones A, B and C. Actinopyrones exhibited coronary vasodilating activities in anesthetized dogs and weakly antimicrobial activities against some Gram-positive bacteria and dermatophytes.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005285:Fermentation; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008826:Microbial Sensitivity Tests; D011714:Pyrans / Q000302:isolation & purification*; D011753:Pyrones / Q000302:isolation & purification* / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D013302:Streptomyces / Q000032:analysis* / Q000145:classification
D011714:Pyrans; D011753:Pyrones; C048200:actinopyrone A; C048201:actinopyrone B; C048202:actinopyrone C