Specific, vascular localization of GABA-transaminase in the guinea pig lung.
The occurrence and distribution of 4-aminobutyrate:2-oxoglutarate transaminase (GABA-T) activity were examined in the guinea pig lung using biochemical and enzymehistochemical methods. Specific GABA-T reactivity was confined primarily to the arteries and to a lesser extent to the veins. No activity could be observed in association with bronchi, alveoli and nerve fibers. Our findings indicate that the GABA-T activity in the lung is specifically located in blood vessels. This study is the first to demonstrate GABA-T activity in peripheral blood vessels.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism*; D000818:Animals; D006168:Guinea Pigs; D006651:Histocytochemistry; D008168:Lung / Q000201:enzymology*; D011651:Pulmonary Artery / Q000201:enzymology; D011667:Pulmonary Veins / Q000201:enzymology
D000612:4-Aminobutyrate Transaminase