title: The effect of age on the pharmacokinetics of pentazocine.
abstract: Pentazocine was administered intravenously to 18 subjects, surgical patients and volunteers, ranging in age from 22 to 90 years. When divided into a young group (10 subjects, age 22-48 years) and an elderly group (8 subjects, age 60-90 years), the total clearance decreased as function of age from 22.14 +/- 4.114 to 11.68 +/- 3.593 ml/min/kg, and the elimination half-life increased from 2.5 +/- 0.71 to 4.11 +/- 1.187 hours. No change in the apparent volume of distribution was observed. Implications of change in clearance and half-life on dosage regimen design are discussed.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010423:Pentazocine / Q000378:metabolism*
chemical_list: D010423:Pentazocine