[Effect of foridon on 45Ca uptake in isolated blood vessels].
In the experiments on rabbit isolated aorta and portal vein phoridone, a vasodilating agent of dihydropyridine series, was shown to exert the blocking effect on the basal uptake of labeled calcium by cells. It was demonstrated in the experiments on rabbit aorta and bovine coronary artery that phoridone inhibits 45Ca uptake stimulated by potassium and noradrenaline. The inhibition of 45Ca uptake enhanced by potassium appeared to be definitely more pronounced in the experiments on coronary artery. The action of phoridone on 45Ca uptake by smooth muscle cells of the vessels did not differ significantly from that of phenyhidine.
D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011169:Portal Vein / Q000187:drug effects* / Q000378:metabolism; D011188:Potassium / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D011817:Rabbits; D014665:Vasodilator Agents / Q000494:pharmacology*
D002132:Calcium Radioisotopes; D011725:Pyridines; D014665:Vasodilator Agents; D009543:Nifedipine; D011188:Potassium; D002118:Calcium; C045912:ryodipine; D009638:Norepinephrine
Vliianie foridona na zakhvat 45Ca v izolirovannykh krovenosnykh sosudakh.