[Effect of metronidazole on the course of experimental anaerobic streptococcal pneumonia].
The effect of metronidazole in experimental anaerobic pneumonia in guinea pigs infected with peptostreptococci has been studied. In the untreated animals the prolonged pathological process in the lungs is mainly associated with the suppression of the functional state of the thymus-dependent link of the immune system. Metronidazole suppresses anaerobic flora, stimulates local immune reaction and arrests the development of inflammatory changes in the lungs. The drug eliminates the unbalance in some subpopulations of immunocompetent cells and restores the number of cells regulating immune response to the normal level. The results obtained in this investigation make it possible to recommend the trial of metronidazole in the complex therapy of peptostreptococcal pneumonia.
D000208:Acute Disease; D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy* / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000187:drug effects; D008795:Metronidazole / Q000627:therapeutic use*; D010462:Peptostreptococcus; D010587:Phagocytosis / Q000187:drug effects; D011014:Pneumonia / Q000188:drug therapy* / Q000276:immunology; D013997:Time Factors
D008795:Metronidazole
Vliianie metronidazola na techenie éksperimental'noĭ anaérobnoĭ streptokokkovoĭ pnevmonii.