Large vessel occlusion and gangrene in systemic lupus erythematosus and "lupus-like" disease. A report of six cases.
Six patients are presented, all of whom had systemic lupus erythematosus or a "lupus-like" disease and who developed major thromboses with gangrene of the extremities. Four of the 6 patients had circulating antiphospholipid antibodies at some point during the course of their illness. These serological markers, which have been associated with a tendency to thrombosis, may have contributed to the development of gangrene in these patients. Histological examination of affected arteries in 4 patients did not show any evidence of vasculitis. One patient in whom antiphospholipid antibodies were negative showed healing vasculitis on histology.
D000328:Adult; D001157:Arterial Occlusive Diseases / Q000209:etiology* / Q000473:pathology; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D005734:Gangrene / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000276:immunology; D014657:Vasculitis / Q000150:complications / Q000473:pathology
D001323:Autoantibodies; D010743:Phospholipids