Comparison of the diuretic effects of single dose frusemide/triamterene and hydrochlorothiazide/amiloride in healthy adults.
The diuretic and potassium- and magnesium-conserving action of a single dose of frusemide/triamterene, F + TRI (40 mg/50 mg), and hydrochlorothiazide/amiloride, HCT + AMI (50 mg/5 mg), fixed combination preparations were compared in ten healthy adults in a randomised double-blind placebo-controlled study. Urinary volume during 24 hours was significantly higher after HCT + AMI ingestion than after F + TRI. The urine and sodium excretions caused by HCT + AMI lasted markedly longer and were smoother than the short and somewhat unpleasant effects of F + TRI. HCT + AMI also spared potassium and magnesium relatively more effectively than F + TRI.
D000328:Adult; D000584:Amiloride / Q000494:pharmacology*; D004311:Double-Blind Method; D004338:Drug Combinations; D005665:Furosemide / Q000494:pharmacology*; D006400:Hematocrit; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology*; D008274:Magnesium / Q000652:urine; D008297:Male; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D013997:Time Factors; D014223:Triamterene / Q000494:pharmacology*; D014556:Urine / Q000032:analysis
D004338:Drug Combinations; D006852:Hydrochlorothiazide; D000584:Amiloride; D005665:Furosemide; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D014223:Triamterene