Synthesis and radiolabeling of heterocyclic food mutagens.
The imidazoquinoline and imidazoquinoxaline food mutagens found in cooked meat are being synthesized by unambiguous methods that allow for the preparation of sufficient quantities of material for biological studies. These methods avoid difficult separations of regioisomeric mixtures of products and are designed to allow incorporation of specific high level tritium labeling.
D000818:Animals; D002417:Cattle; D005504:Food Analysis; D005506:Food Contamination; D008460:Meat / Q000009:adverse effects / Q000032:analysis; D009153:Mutagens / Q000138:chemical synthesis*; D011804:Quinolines / Q000138:chemical synthesis; D014316:Tritium
D009153:Mutagens; D011804:Quinolines; D014316:Tritium; C029216:2-amino-3-methylimidazo(4,5-f)quinoline; C036989:2-amino-3,4-dimethylimidazo(4,5-f)quinoline