[Effect of kainic acid on the metabolism of intracellular calcium and oxidation-reduction processes in structures of the cerebral cortex].
The dynamics of calcium ions bound within intracellular membranes (Ca2+b), changes of redox--state and bioelectrical activity were studies in vital brain preparation after kainic acid (KA) application either to the micro--zones iontophoretically or to the whole surface of the preparation. The Ca2+b dynamics depended on KA dose and included release of Ca2+b as well as bounding of calcium attracted from extracellular space. The early period of the reaction consisted of an increased intracellular reduction equivalents and a release of Ca2+b. Theme correlating processes were followed by "seizure" activity specific for the KA effect. The calcium free bounding effect started to prevail with increasing KA dose.
D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002415:Cats; D002463:Cell Membrane Permeability / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D002751:Chlortetracycline / Q000378:metabolism; D007608:Kainic Acid / Q000494:pharmacology*; D009474:Neurons / Q000378:metabolism; D010084:Oxidation-Reduction; D013574:Synaptosomes / Q000378:metabolism
D007608:Kainic Acid; D002118:Calcium; D002751:Chlortetracycline
Vliianie kainovoĭ kisloty na obmen vnutrikletochnogo kal'tsiia i okislitel'no-vosstanovitel'nye protsessy v strukturakh kory golovnogo mozga.