Adhesion and aggregation of thrombin prestimulated human platelets: evaluation of surface-bound fibrinogen and surface-bound albumin.
The effect of prestimulation of human washed platelets with thrombin on their ability to adhere to and form aggregates on fibrinogen- and albumin-coated glass has been studied. Prestimulation of platelets does not alter platelet adhesion to surface bound albumin and fibrinogen. Our data for both protein coatings support a mechanism of adherence of single prestimulated platelets before formation of surface-bound aggregates from single platelets arriving from the flow. When whole blood contacts an artificial surface, thrombin will likely influence the platelet component of thrombus formation.
D002462:Cell Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000502:physiology; D005340:Fibrinogen / Q000378:metabolism*; D005898:Glass; D006801:Humans; D007700:Kinetics; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D012709:Serum Albumin / Q000378:metabolism*; D013917:Thrombin / Q000502:physiology*
D012709:Serum Albumin; D005340:Fibrinogen; D013917:Thrombin