title: [Reactions and complications in the radiotherapy of pancreatic cancer].
abstract: Radiation reactions were assessed in 140 pancreatic cancer patients. They were noted in 103 (73.5%) patients: general radiation reactions in 62 patients and local reactions in 41. Noticeable radiation reactions were noted in 17.5%, moderate in 36.9% and insignificant in 45.6% of the patients. The use of braking radiation with the energy of 18-25 MeV caused a decrease in the total number of radiation reactions to 20%, the number of noticeable radiation reactions as compared to those in gamma-beam therapy reduced 3-fold. Changes of external secretory and insular function of the pancreas caused by irradiation were studied. It was established that radiation therapy caused no inhibition of these functions, and in 45.9% of the patients it brought about their improvement or normalization. Complications of radiation therapy were observed after 7-48 mo in 21 patients for gamma-beam therapy and presented with vertebral osteopathy in the exposed site, intestinal trophic ulcer and peptic ulcer recurrence. Radiation reactions caused the termination of therapy of 6 (4.3%) patients, a radiation therapy plan in 21 (15%) patients was changed and a 5-7-day interruption or a split course of irradiation was recommended. The main reaction was a general radiation reaction, and gastric or intestinal reactions were the second reason for the discontinuation or change of a radiation therapy plan.
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects*
vernacular_title: Reaktsii i oslozheniia pri luchevom lechenii raka podzheludochnoĭ zhelezy.