Persistence of deafferentation-induced presynaptic dendrites in the cerebellar cortex of adult rats.
The paper provides morphological evidence for a long-lasting morphogenetic potential of the excitatory granule cells and the inhibitory small Golgi neurons to manufacture and to maintain presynaptic sites on their otherwise exclusively postsynaptic dendritic processes and somata. The development of new dendrodendritic and somato-dendritic synapses follows and is the direct consequence of the mossy fiber deafferentation of the cerebellar cortex. By GABA-immunocytochemistry it was demonstrated that not only Golgi axons but also the Golgi somata and presynaptic dendrites contain GABA, suggesting that this inhibitory transmitter is an operating factor in many of the newly formed synapses.
D000344:Afferent Pathways / Q000033:anatomy & histology; D000818:Animals; D001933:Brain Stem / Q000033:anatomy & histology*; D002525:Cerebellar Cortex / Q000033:anatomy & histology*; D003712:Dendrites / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009412:Nerve Fibers / Q000648:ultrastructure; D009473:Neuronal Plasticity; D011689:Purkinje Cells / Q000648:ultrastructure; D051381:Rats; D013569:Synapses / Q000648:ultrastructure*; D013570:Synaptic Membranes / Q000648:ultrastructure; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005680:gamma-Aminobutyric Acid