title: [Clinical picture, diagnosis and treatment of the brain lesions in lymphosarcomas].
abstract: The study group included 11 patients with brain metastases of disseminated lymphosarcoma. The most common clinical course was progression of the disease which manifested itself in the advancement of general cerebral symptoms as well as focal ones indicative of hemisphere, subcortex or cerebral trunk involvement. High single intravenous doses of cyclophosphamide and rubomycin and radiotherapy or their combination appeared highly effective in cases of brain specific involvement: complete or partial regression of neurologic symptoms was observed in 7 and 3 patients, respectively. Radiation treatment was followed by COP, COAP or CAMP polychemotherapy to curb extracerebral disease progression. Low median survival of patients with brain metastases (5.1 months) was due to extracerebral tumor progression. However, brain metastases were not immediate death-causing factors.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D003131:Combined Modality Therapy / Q000379:methods; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000008:administration & dosage; D004338:Drug Combinations / Q000008:administration & dosage; D005260:Female; D005720:Gamma Rays / Q000627:therapeutic use; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D011879:Radiotherapy Dosage; D013997:Time Factors; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; D003561:Cytarabine; D011344:Procarbazine; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone; D008727:Methotrexate
vernacular_title: Klinika, diagnostika i lechenie porazheniĭ golovnogo mozga pri limfosarkomakh.