Amyloidosis in a dog: treatment with dimethylsulfoxide.
A dog with hypoalbuminemia, proteinuria, and renal amyloidosis was treated with dimethylsulfoxide for 2 years. During a 1-year period, serum albumin concentrations increased to within normal range. The 24-hour urinary protein excretion was 5.7 g before treatment with dimethylsulfoxide. Two years after initiation of treatment, the 24-hour urinary protein excretion was 3.7 g. Removal of a testicle containing a Sertoli cell tumor and treatment of interdigital pyoderma may have been factors in the dog's clinical improvement. The only adverse effect from the dimethylsulfoxide treatment was the characteristic disagreeable odor.
D000686:Amyloidosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male
D004121:Dimethyl Sulfoxide