Systemic absorption of miconazole from the vagina.
The serum concentrations of miconazole were measured in 11 healthy adult females for 72 hours following a single 1200 mg vaginal pessary. The mean peak serum miconazole concentration was 10.4 micrograms/l and the mean elimination half life was 56.8 h. The mean area under the serum concentration time curve was 967 micrograms/l.h. The calculated mean systemic bioavailability of the vaginal pessary was 1.4%. There was large intersubject variation in serum miconazole pharmacokinetics. This formulation may provide effective single dose treatment for vaginal candidosis.
D000042:Absorption; D000282:Administration, Intravaginal; D000328:Adult; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008825:Miconazole / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D014621:Vagina / Q000378:metabolism*
D008825:Miconazole