[Possibility of the pharmacologic treatment of post-ischemic myocardial damage].
The influence of ethacizin and nonachlazin on the size of myocardial necrosis, caused by 1.5-hour partial occlusion of the coronary artery was studied in conscious rabbits. The drugs were administered for 3 days, after the blood supply in the ischemic zones had been recovered. Ethacizin had a more pronounced effect, as compared to nonachlazin. The data obtained suggest that in the case of isochemic heart disease pharmacotherapy can be used not only for the prevention and arrest of anginal attacks, but also for the treatment of postischemic cardiac lesions.
D000787:Angina Pectoris / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D003327:Coronary Disease / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016293:Moricizine / Q000031:analogs & derivatives*; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D009628:Nonachlazine / Q000627:therapeutic use*; D010640:Phenothiazines / Q000627:therapeutic use*; D011817:Rabbits
D010640:Phenothiazines; C027240:diethylamino-ethmozine; D016293:Moricizine; D009628:Nonachlazine
Vozmozhnost' farmakologicheskogo vozdeĭstviia na postishemicheskoe povrezhdenie miokarda.