Effect of plaster-cast immobilization on the bone.
Plaster-cast of the right hind limb resulted in immobilization osteoporosis in rats. The alteration was characterized by loss of the bony substance as well as by a partial transformation of lamellar bone to primordial osseous tissue. In the basis of histological and histomorphometric findings, an accelerated osteoclastic activity, an increased osteocytic osteolysis and a decreased ossification are responsible for the observed changes.
D000818:Animals; D001842:Bone and Bones / Q000473:pathology; D002370:Casts, Surgical; D004195:Disease Models, Animal; D007103:Immobilization; D010024:Osteoporosis / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains