Cannflavin A and B, prenylated flavones from Cannabis sativa L.
Two novel prenylated flavones, termed Cannflavin A and B, were isolated from the cannabinoid free ethanolic extract of Cannabis sativa L. Both compounds inhibited prostaglandin E2 production by human rheumatoid synovial cells in culture.
D001172:Arthritis, Rheumatoid / Q000378:metabolism; D002188:Cannabis / Q000032:analysis*; D047309:Flavones; D006801:Humans; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000302:isolation & purification*; D011458:Prostaglandins E / Q000096:biosynthesis; D013329:Structure-Activity Relationship; D013582:Synovial Fluid / Q000187:drug effects / Q000378:metabolism
D047309:Flavones; D010936:Plant Extracts; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; C045457:cannflavin