[Therapeutic action of an antioxidant in chronic emotional-pain stress in the rat].
Chronic emotional pain stress in rats causes disturbances of the cardiovascular system function (increase in arterial pressure and in heart rate), typical of neuroses-like state, and changes of the vegetative nervous system reactivity tested with functional load by two-hour hypokinesis. Increase in spleen weight is observed as well as a tendency to adrenals weight increase, a decrease of Na, K-ATPase activity and activation of lipid peroxidation in cortical and hippocampal homogenates. Administration of F-801 antioxidant according to therapeutic scheme after the end of stress action, restores normal function of the cardiovascular system, normal reactivity of the vegetative nervous system, decreases adrenals weight and increases the weight of thymus and also normalizes ATPase activity and the level of lipid peroxidation. A backward correlation dependence of the Na, K-ATPase activity on the level of malondialdehyde in the brain tissue has been established.
D000307:Adrenal Gland Diseases / Q000523:psychology; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000523:psychology; D002908:Chronic Disease; D008297:Male; D009422:Nervous System Diseases / Q000523:psychology; D009497:Neurotic Disorders / Q000188:drug therapy; D009930:Organic Chemicals; D010146:Pain / Q000188:drug therapy*; D011602:Psychophysiologic Disorders / Q000188:drug therapy*; D051381:Rats; D013158:Splenic Diseases / Q000523:psychology; D013315:Stress, Psychological / Q000188:drug therapy*
D000975:Antioxidants; D009930:Organic Chemicals; C045988:F 801
Terapevticheskoe deĭstvie antioksidanta pri khronicheskom émotsional'no-bolevom stresse u krys.