Comparative in vitro evaluation of cefonicid, cefazolin, and penicillin against viridans group streptococci isolated from blood.
The in vitro activity of cefonicid against 60 strains of viridans group streptococci isolated from blood of patients with bacteremia and infective endocarditis was compared with those of cefazolin and penicillin. Cefonicid was less active than cefazolin, and both cephalosporins were less active than penicillin. The MIC50 and MIC90 for the strains tested were 0.06 and 1 microgram/ml for penicillin, 0.125 and 8 micrograms/ml for cefazolin, and 4 and 32 micrograms/ml for cefonicid.
D002435:Cefamandole / Q000031:analogs & derivatives* / Q000494:pharmacology; D002437:Cefazolin / Q000494:pharmacology*; D015790:Cefonicid; D004697:Endocarditis, Bacterial / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D018805:Sepsis / Q000382:microbiology*; D013290:Streptococcal Infections / Q000382:microbiology*; D013291:Streptococcus / Q000187:drug effects*
D010406:Penicillins; D002435:Cefamandole; D015790:Cefonicid; D002437:Cefazolin