title: Leucosulfakinin, a sulfated insect neuropeptide with homology to gastrin and cholecystokinin.
abstract: A sulfated, myotropic neuropeptide termed leucosulfakinin (Glu-Gln-Phe-Glu-Asp-Tyr(SO3H)-Gly-His-Met-Arg-Phe-NH2) was isolated from head extracts of the cockroach Leucophaea maderae. The peptide exhibits sequence homology with the hormonally active portion of the vertebrate hormones human gastrin II and cholecystokinin, suggesting that these peptides are evolutionarily related. Six of the 11 amino acid residues (55 percent) are identical to those in gastrin II. In addition, the intestinal myotropic action of leucosulfakinin is analogous to that of gastrin.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001048:Aplysia; D003386:Brachyura; D002766:Cholecystokinin / Q000235:genetics; D003058:Cockroaches; D005755:Gastrins / Q000235:genetics; D006801:Humans; D007301:Insect Hormones / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D009479:Neuropeptides; D012689:Sequence Homology, Nucleic Acid
chemical_list: D005755:Gastrins; D007301:Insect Hormones; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; C050024:leucosulfakinin; D002766:Cholecystokinin