Urinary and fecal excretions and absorption of a large supplement of selenium: superiority of selenate over selenite.
A correction needs to be made to the form of selenium used in earlier studies; what was believed to be selenite-Se in solution is now known to have been selenate-Se. In the present study, excretion of Se was followed in 13 women after ingestion of 1 mg Se as selenite or selenate in solution. Fecal excretion of selenate-Se was less than for selenite-Se reflecting a higher apparent absorption [94 +/- 4% (SD), 62 +/- 14%, respectively]. Peak excretion of Se occurred 3 h earlier for selenate-Se than for selenite-Se and was 6 times higher. Total urinary excretion of selenate-Se was 3 times that of selenite-Se and still 2 times as high when expressed as % absorbed dose. Total recovery of Se in urine and feces was similar for both forms. There was remarkable agreement between these results and those reported earlier for selenate-Se (Selovet-1) and selenite-Se.
D000328:Adult; D001682:Biological Availability; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D064586:Selenic Acid; D020887:Selenious Acid; D012643:Selenium / Q000378:metabolism* / Q000652:urine; D018036:Selenium Compounds
D018036:Selenium Compounds; D020887:Selenious Acid; D012643:Selenium; D064586:Selenic Acid