Uptake of the hormone 1,25-dihydroxyvitamin D3 by the dog liver.
The hepatic uptake of the hormone 1,25-dihydroxyvitamin D3 has been studied, in vivo, using the multiple indicator dilution technique. The fractional uptake of 1,25-dihydroxyvitamin D3 during a single circulatory passage across the dog liver has been estimated at 34.4 +/- 3.3% while its hepatic clearance was estimated at 364.3 +/- 94.1 mL/min. The hepatic uptake of 1,25-dihydroxyvitamin D3 is discussed in relation to its systemic bioavailability following intravenous or oral administration as well as in relation to the hepatic uptake of other vitamin D sterols; it is postulated that the hepatic uptake of vitamin D sterols does not seem to be mediated by specific receptors on the liver plasma membrane; it seems, however, that the hepatic uptake of vitamin D sterols may be inversely related to their relative affinity for the circulating carrier, the vitamin D binding protein.
D000818:Animals; D001774:Blood Chemical Analysis; D002117:Calcitriol / Q000008:administration & dosage / Q000378:metabolism*; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism*; D011169:Portal Vein
D002117:Calcitriol