Effects of GABA-mimetic drugs on turnover of histamine in the mouse brain.
The effect of GABA-mimetics on histaminergic activity in the mouse brain was investigated. Systemic administration of muscimol (2 and 5 mg/kg), THIP (5-15 mg/kg) and aminooxyacetic acid (AOAA) (25 mg/kg) but not baclofen (2.5-15 mg/kg) inhibited the pargyline (65 mg/kg)-induced accumulation of tele-methylhistamine (t-MH). There was no regional difference in the inhibitory effect of muscimol on the t-MH accumulation by pargyline treatment. Muscimol and AOAA also inhibited decrease in the histamine (HA) level induced by alpha-fluoromethylhistidine (50 mg/kg), a specific inhibitor of histidine decarboxylase. These results suggest that these GABA-mimetics reduce the HA turnover in the mouse brain.
D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D006632:Histamine / Q000378:metabolism*; D007555:Isoxazoles / Q000494:pharmacology; D008297:Male; D008761:Methylhistamines / Q000032:analysis; D008762:Methylhistidines / Q000494:pharmacology; D051379:Mice; D009118:Muscimol / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D007555:Isoxazoles; D008761:Methylhistamines; D008762:Methylhistidines; D000625:Aminooxyacetic Acid; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; C028309:alpha-fluoromethylhistidine; D006632:Histamine; D001418:Baclofen; C015542:gaboxadol; C020404:tele-methylhistamine