Formation of an N-nitrosamine by oxidation.
Tolazamide, an antidiabetic drug, was found to produce N-nitrosohexamethyleneimine (NHM) upon exposure to an oxidizing agent and in the absence of a nitrosating agent. The oxidizing agents were either hydrogen peroxide or oxygen.
D002273:Carcinogens; D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D009602:Nitrosamines / Q000032:analysis; D010084:Oxidation-Reduction; D014042:Tolazamide / Q000032:analysis
D002273:Carcinogens; D009602:Nitrosamines; C002742:N-nitrosoperhydroazepine; D014042:Tolazamide