Treatment of Staphylococcus aureus endocarditis: an analysis based on 25 proven cases.
Twenty-five consecutive unequivocal cases of Staphylococcus aureus endocarditis in a single centre over 5 years were reviewed. Despite an unusually high proportion of prosthetic infections an early mortality of only 16% was observed. Analysis reveals that early diagnosis and prompt effective antibiotic chemotherapy were important factors in achieving this low mortality. Monotherapy with an isoxazolyl penicillin (flucloxacillin) was shown to be as effective as combination therapies, and there was a significant association between the use of aminoglycosides and subsequent renal damage.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003023:Cloxacillin / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000401:mortality; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000401:mortality; D013211:Staphylococcus aureus
D003023:Cloxacillin