[Mechanism of the anti-anginal action of korinfar].
The effect of corinfar on the blood plasma Ca2+ content and oxyhemoglobin dissociation curve was studied in 52 patients with ischemic heart disease. The drug was administered in a dose of 60 mg/day and to 5 patients in a dose of 90 mg/day for 2 weeks. A complete disappearance of angina attacks and ECG normalization were observed in 37 patients, a good effect was noted in 30 patients and no effect was seen in 13 patients. A significant decrease of Ca2+ content during treatment was noted in patients with effort angina of mild and moderate degrees. Parallelism between Ca2+ content decrease and the drug efficacy was revealed.
D000328:Adult; D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy*; D002118:Calcium / Q000097:blood; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002908:Chronic Disease; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy; D004341:Drug Evaluation; D006801:Humans; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D010108:Oxyhemoglobins / Q000378:metabolism; D005082:Physical Exertion
D002121:Calcium Channel Blockers; D010108:Oxyhemoglobins; D009543:Nifedipine; D002118:Calcium
K mekhanizmu antianginal'nogo deĭstviia korinfara.