title: Existence of glucose-6-phosphate dehydrogenase-like locus on chromosome 17.
abstract: Hybridization of DNA samples prepared from flow-sorted human chromosomes with a cDNA probe for the X-linked glucose-6-phosphate dehydrogenase (G6PD) suggested the existence of the G6PD-like locus on chromosome 17. Southern hybridization analysis of endonuclease-digested DNA samples from the human-mouse hybrid cell line with human chromosome 17, and from control human and mouse cells, proved that not only X chromosomes, but also chromosome 17, contain DNA sequences that are hybridizable with the G6PD cDNA probe. The G6PD-like locus on chromosome 17 could be a putative pseudogene or a functional gene for the fetal brain-specific G6PD isozyme or other protein.
mesh_terms: D002874:Chromosome Mapping; D002902:Chromosomes, Human, 16-18; D003001:Cloning, Molecular; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006801:Humans; D009693:Nucleic Acid Hybridization
chemical_list: D005954:Glucosephosphate Dehydrogenase