Synthesis of sulfur analogues of alkyl lysophospholipid and neoplastic cell growth inhibitory properties.
Five sulfur-containing phospholipid analogues (compounds 1-5) of alkyl lysophospholipid (1-O-alkyl-2-O-methyl-rac-glycero-3-phosphocholine, ALP) were synthesized and tested for inhibition of neoplastic cell proliferation with two human ovarian carcinoma cell lines in a clonogenic assay and with the HL-60 promyelocytic leukemia cell line. Compared with 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OMe), the most active reference analogue, these thio analogues are at least as active against HL-60 cells, and the 1-S-hexadecyl-2-O-ethyl analogue (2) is twice as active in the clonogenic assays.
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008246:Lysophospholipids; D010743:Phospholipids / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013455:Sulfur; D014410:Tumor Stem Cell Assay
D000970:Antineoplastic Agents; D008246:Lysophospholipids; D010743:Phospholipids; D013455:Sulfur