[Effect of antidepressants on the convulsive action of thiosemicarbazide, strychnine and corasol].
Orally administered amitryptiline (25 and 50 mg/kg) protected animals against fatal convulsions induced by thiosemicarbazide, strychnine and metrazole. Vilaxazine had a protecting effect against death induced by strychnine. Impramine, maprotiline, mianserine and pirlindole (pyrazidol) only somewhat prolonged the latend period of convulsions and death, while incazane, caroxazone, nomifenzine and trazodone had practically no effect on the action of the three convulsants under study.
D000818:Animals; D000927:Anticonvulsants; D000928:Antidepressive Agents / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors*; D012663:Semicarbazides / Q000037:antagonists & inhibitors*; D013331:Strychnine / Q000037:antagonists & inhibitors*
D000927:Anticonvulsants; D000928:Antidepressive Agents; D012663:Semicarbazides; C005151:thiosemicarbazide; D013331:Strychnine; D010433:Pentylenetetrazole
Vliianie antidepressantov na sudorozhnoe deĭstvie tiosemikarbazida, strikhnina i korazola.