[Animal experiment studies of the modification of pregnancy by heterologous antibodies to placental antigens].
Pregnancy impairment in mice with abortion and fetal resorption was caused by rabbit antibodies to total mitochondrial, mitochondrial membrane and microsomal fractions of mouse placentas injected intraperitoneally at 12-14 days of gestation. Antibodies to cytosol and soluble mitochondrial constituents were ineffective. According to the marker distribution in the biologically active and inactive fractions membrane-bound antigens are thought to be responsible for the abortigenic effect.
D000022:Abortion, Spontaneous / Q000276:immunology; D000818:Animals; D000910:Antibodies, Heterophile / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D002467:Cell Nucleus / Q000276:immunology; D003600:Cytosol / Q000276:immunology; D005260:Female; D005327:Fetal Resorption / Q000276:immunology; D007425:Intracellular Membranes / Q000276:immunology; D051379:Mice; D008861:Microsomes / Q000276:immunology; D008928:Mitochondria / Q000276:immunology; D010920:Placenta / Q000276:immunology*; D011247:Pregnancy; D011270:Pregnancy, Animal
D000910:Antibodies, Heterophile; D000941:Antigens
Tierexperimentelle Untersuchungen zur Beeinflussung der Schwangerschaft durch heterologe Antikörper gegen Plazentaantigene.