Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.
A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.
D000818:Animals; D001483:Base Sequence; D002417:Cattle; D002874:Chromosome Mapping; D002902:Chromosomes, Human, 16-18; D004247:DNA; D005796:Genes; D006801:Humans; D009693:Nucleic Acid Hybridization; D011493:Protein Kinase C / Q000235:genetics*; D051381:Rats
D004247:DNA; D011493:Protein Kinase C