[Familial dysphagia].
The etiology of achalasia and diffuse esophageal spasm remains unknown. We report on two families (father/son, mother/son) with achalasia and esophageal spasm, respectively, who were examined by radiology, endoscopy and manometry. One patient (mother) died from aspiration pneumonia. These observations support the hypothesis of a genetic trait in some cases of esophageal motility disorders. In addition, the coincidence of familial achalasia and esophageal spasm is in support of a close relationship of both diseases. Achalasia is a potentially letal disorder.
D000328:Adult; D000368:Aged; D003680:Deglutition Disorders / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D004931:Esophageal Achalasia / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D004947:Esophagus / Q000473:pathology; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011859:Radiography
Familiäre Dysphagie.