[Modification of the radiosensitizing effect of metronidazole by 5-fluorouracil and caffeine].
A study was made of the combined effect of 5-fluorouracil, metronidazole, caffeine and radiation on radiosensitivity of Pliss lymphosarcoma and protein synthesis rate during the first few hours following irradiation. A complete regression of the tumor was noted in 100% of animals after a 3-fold exposure. Effective postirradiation inhibition of protein synthesis was achieved by injection of metronidazole and caffeine together with 5-fluorouracil.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D004347:Drug Interactions; D005472:Fluorouracil / Q000494:pharmacology*; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism / Q000532:radiotherapy*; D008795:Metronidazole / Q000494:pharmacology*; D009363:Neoplasm Proteins / Q000096:biosynthesis; D011838:Radiation-Sensitizing Agents; D051381:Rats; D013997:Time Factors
D009363:Neoplasm Proteins; D011838:Radiation-Sensitizing Agents; D008795:Metronidazole; D002110:Caffeine; D005472:Fluorouracil
Modifikatsiia radiosensibiliziruiushchego éffekta metronidazola 5-ftoruratsilom i kofeinom.