Acute interstitial nephritis associated with intermittent rifampin use.
Rifampin is a widely used antimicrobial agent, most commonly administered in the treatment of tuberculosis. Since its introduction in the late 1960s, rifampin has become a standard agent in the treatment of tuberculosis, especially with the acceptance of short-course chemotherapy in the U.S. Rifampin also is being used with increasing frequency in the treatment of nontuberculous infections, especially serious staphylococcal infections. While rifampin usually is well tolerated in most patients, adverse effects, including serious forms of toxicity, have been reported. Some of these adverse effects include liver toxicity and various immunologic reactions such as skin rashes, eosinophilia, and interstitial nephritis. This report documents a case of acute interstitial nephritis, most likely secondary to intermittent rifampin administration.
D000208:Acute Disease; D005260:Female; D006801:Humans; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects*; D012646:Self Administration
D012293:Rifampin