Compounds that inhibit chymotrypsin and cell replication.
Several compounds have been tested for their ability to inhibit bovine pancreatic alpha-chymotrypsin (Ki) and their ability to inhibit cell replication (IC50). There is good agreement over three orders of magnitude between the Ki and the IC50 values of these compounds. The data support the hypothesis that a cellular, chymotrypsin-like activity is necessary for cell replication.
D000818:Animals; D001897:Boronic Acids / Q000494:pharmacology; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002918:Chymotrypsin / Q000378:metabolism*; D007700:Kinetics; D051379:Mice; D010179:Pancreas / Q000201:enzymology; D011480:Protease Inhibitors / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D001897:Boronic Acids; D011480:Protease Inhibitors; C037240:phenylethane boronic acid; D002918:Chymotrypsin