title: Purpura fulminans in pneumococcal sepsis.
abstract: Two cases of pneumococcal sepsis in splenectomized patients were complicated by purpura fulminans. In addition, acute renal failure developed in both patients, and myolysis in one. Immunological findings in the patient with myolysis suggest a possible role of pneumococcal antigen-containing circulating immune complexes in the pathogenesis of these complications.
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D002699:Chlorambucil / Q000627:therapeutic use; D005260:Female; D005734:Gangrene / Q000150:complications / Q000503:physiopathology; D006689:Hodgkin Disease / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007074:Immunoglobulin G / Q000302:isolation & purification; D008223:Lymphoma / Q000150:complications; D008466:Mechlorethamine / Q000627:therapeutic use; D011008:Pneumococcal Infections / Q000150:complications* / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use; D011344:Procarbazine / Q000627:therapeutic use; D011693:Purpura / Q000150:complications* / Q000209:etiology / Q000503:physiopathology; D013156:Splenectomy; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D007074:Immunoglobulin G; D002699:Chlorambucil; D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D011241:Prednisone