5-Hydroxytryptamine M-receptor antagonism to prevent cisplatin-induced emesis.
The administration to the ferret of cisplatin, 10mg/kg (i.v.), caused an intense emetic response that was prevented by ICS 205-930 (0.1 and 1.0 mg/kg i.v.) and metoclopramide (4.0 mg/kg i.v.). Smaller doses of ICS 205-930 (0.01 mg/kg i.v.) and metoclopramide (2.0 mg/kg i.v.) attenuated the emetic response to cisplatin. It is concluded that the potent action of ICS 205-930 against cisplatin-induced emesis is the consequence of a 5-hydroxytryptamine M-receptor antagonism which may also contribute to the antiemetic action of metoclopramide.
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology; D002945:Cisplatin / Q000037:antagonists & inhibitors*; D005289:Ferrets; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D011985:Receptors, Serotonin / Q000187:drug effects*; D000077526:Tropisetron; D014839:Vomiting / Q000139:chemically induced* / Q000517:prevention & control
D000932:Antiemetics; D007211:Indoles; D011985:Receptors, Serotonin; D000077526:Tropisetron; D008787:Metoclopramide; D002945:Cisplatin