Single-dose antibiotic prophylaxis in high-risk patients undergoing cesarean section. A comparative trial.
A prospective, double-blind study was performed to evaluate the comparative efficacy of single- and multiple-dose antimicrobial prophylaxis for preventing infection in high-risk patients undergoing cesarean section. One hundred fifty-eight patients were randomly assigned to receive either a single perioperative dose of mezlocillin, three doses of mezlocillin or three doses of cefoxitin. The incidence of endometritis was 5.9%, 4.0% and 4.0%, respectively. The incidence of febrile morbidity was 5.9%, 2.0% and 6.1%, respectively. These differences are not statistically significant. The single perioperative dose of mezlocillin was as effective as the three-dose regimen of either mezlocillin or cefoxitin.
D000328:Adult; D001424:Bacterial Infections / Q000517:prevention & control*; D002440:Cefoxitin / Q000008:administration & dosage / Q000627:therapeutic use*; D002585:Cesarean Section; D004311:Double-Blind Method; D004716:Endometritis / Q000209:etiology / Q000382:microbiology; D005260:Female; D006801:Humans; D008802:Mezlocillin / Q000008:administration & dosage / Q000627:therapeutic use*; D011183:Postoperative Complications; D011247:Pregnancy; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D014552:Urinary Tract Infections / Q000209:etiology / Q000382:microbiology
D002440:Cefoxitin; D008802:Mezlocillin