Efficacy, toxicity and metabolism of imidocarb dipropionate in the treatment of Babesia ovis infection in sheep.
An intramuscular dose of 1.2 mg kg-1 of imidocarb dipropionate (IMDP) was effective in controlling fatal infections with Babesia ovis in sheep. The sheep were infected by the intravenous injection of sheep blood containing B ovis. A severe recrudescence of infection occurred in most sheep 10 to 14 days after therapy but this could be controlled by a second dose of 1.2 mg kg-1 IMDP. Studies on the toxicology, residues and metabolism of IMDP showed this to be a safe dosage regimen. Transient or mild signs of toxicity were seen at 2.4 and 4.8 mg kg-1 IMDP. Severe toxicity was observed in sheep treated with 9.6 mg kg-1.
D000818:Animals; D001404:Babesiosis / Q000188:drug therapy* / Q000378:metabolism; D002224:Carbanilides / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D004341:Drug Evaluation / Q000662:veterinary; D005260:Female; D007095:Imidocarb / Q000009:adverse effects / Q000031:analogs & derivatives / Q000378:metabolism / Q000627:therapeutic use*; D008274:Magnesium / Q000097:blood; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000469:parasitology; D014508:Urea / Q000097:blood
D002224:Carbanilides; D007095:Imidocarb; D014508:Urea; D003404:Creatinine; D008274:Magnesium; C031719:imidocarb dipropionate