Hydrogen ion-coupled transport of D-glucose by phlorizin-sensitive sugar carrier in intestinal brush-border membranes.
In rabbit intestinal brush-border membrane vesicles, Na+-independent D-glucose uptake in the presence of an inside-negative transmembrane potential was found to be stimulated by an imposed pH gradient. Na+-independent, pH-dependent and phlorizin-sensitive D-glucose-evoked potentials could be recorded from isolated toad intestine. The obtained data suggest that phlorizin-sensitive D-glucose carriers of intestinal brush-border membrane can interact with H+ when Na+ is absent.
D000200:Action Potentials; D000818:Animals; D001692:Biological Transport; D005947:Glucose / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism; D008871:Microvilli / Q000378:metabolism*; D009004:Monosaccharide Transport Proteins / Q000502:physiology*; D010695:Phlorhizin / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D011817:Rabbits; D012964:Sodium / Q000494:pharmacology
D009004:Monosaccharide Transport Proteins; D012964:Sodium; D010695:Phlorhizin; D005947:Glucose; D011188:Potassium