The significance of cerebrospinal fluid routine screening for neurosyphilis.
From 1980 to 1985 the cerebrospinal fluid microhaemagglutination assay for Treponema pallidum antibodies (MHA:TP-CSF) was routinely examined from 10 386 consecutive CSF samples of more than 10,000 patients admitted to a large neurological unit in Helsinki. Twenty one patients were considered to have neurosyphilis on the basis of clinical, serological and CSF findings. The MHA:TP-CSF test was positive in 14 patients, in 4 patients the result was undefined, and in 3 patients negative. No false-positive results were obtained. Ten of the patients had no previous history of syphilis demonstrating the value of this type of routine screening, and in only 2 of these patients the diagnosis was suspected by clinicians before the CSF examination. The serum MHA:TP was positive in all examined 18 neurosyphilis patients indicating its value for the routine screening method instead of the CSF examination.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid*; D005260:Female; D005387:Finland; D006386:Hemagglutination Tests; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009494:Neurosyphilis / Q000134:cerebrospinal fluid / Q000517:prevention & control*; D013588:Syphilis Serodiagnosis
D000907:Antibodies, Bacterial