title: Cimetidine absorption in humans during sucralfate coadministration.
abstract: Cimetidine absorption after a single 300 mg oral dose was evaluated in six normal subjects in the absence or presence of sucralfate. Sucralfate was ingested four times a day for 2 days prior to and for two additional doses on the day of cimetidine ingestion. Sucralfate coadministration had no statistically significant influence on the rate or extent of cimetidine absorption.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000535:Aluminum / Q000008:administration & dosage / Q000494:pharmacology*; D001682:Biological Availability / Q000187:drug effects; D002927:Cimetidine / Q000008:administration & dosage / Q000378:metabolism*; D004341:Drug Evaluation; D004347:Drug Interactions; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D011897:Random Allocation; D013392:Sucralfate
chemical_list: D013392:Sucralfate; D002927:Cimetidine; D000535:Aluminum