title: 42K spaces in submandibular gland of early postnatal rats: effects of carbachol and transport inhibitors.
abstract: Equivalent spaces of 42K were measured in fragments of the submandibular gland of 1-, 7-, 14- and 21-day-old and adult rats in the absence and presence of carbachol and the transport inhibitors ouabain and furosemide. The results indicate that the 42K space was increased by carbachol in an ouabain-sensitive manner at all ages studied and that part of the secretagogue-stimulated K uptake occurred by way of a furosemide-sensitive transport system in the latter part of the postnatal period and in the adult.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D002217:Carbachol / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology*; D010042:Ouabain / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*; D011197:Potassium Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism*
chemical_list: D011197:Potassium Radioisotopes; D010042:Ouabain; D005665:Furosemide; D002217:Carbachol; D011188:Potassium