title: Placental transfer of anticonvulsants in the rabbit: the effect of maternal protein binding and fetal flow.
abstract: The fetal-to-maternal ratios of carbamazepine, antipyrine and phenytoin are principally determined by maternal protein binding, though greater lipid solubility may enhance the transfer of valproate compared to that of other drugs at high flows. Placental clearance of all anticonvulsants showed flow-dependent characteristics. This is in line with our findings for basic drugs.
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005333:Fetus / Q000502:physiology*; D007700:Kinetics; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011485:Protein Binding; D011817:Rabbits
chemical_list: D000927:Anticonvulsants