Cardiovascular and pulmonary activity of platelet-activating factor (PAF-acether) and its derivatives.
Stereoselective synthesis and biological properties of PAF-acether, its enantiomer and some analogues of both are reported. The results clearly indicate that the ONIUM SIZE and SHAPE of the various compounds tested are important in determining guinea-pig bronchoconstriction and human platelet aggregation.
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects*; D008168:Lung / Q000187:drug effects*; D008297:Male; D008968:Molecular Conformation; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D013237:Stereoisomerism
D010972:Platelet Activating Factor