[Effect of electron and steric interactions on the radioprotective properties of indolylalkylamines].
Molecular mechanisms of radioprotective action of some substituted indolylalkylamines are discussed in terms of the statistical correlation analysis. It was established that electron and steric properties of the substituents are the factors influencing the radioprotective efficiency of these compounds. It was shown that the correlation obtained, relating the structure of the compounds to the radioprotective effect, may be applied in studies of the mechanism of action of the preparations and for the purposeful synthesis of new compounds.
D000818:Animals; D051379:Mice; D008968:Molecular Conformation; D011837:Radiation-Protective Agents; D013329:Structure-Activity Relationship; D014363:Tryptamines / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D014363:Tryptamines
Vliianie élektronnykh i stericheskikh vzaimodeĭstviĭ na protivoluchevye svoĭstva indolilalkilaminov.