title: Centromere spreading and out-of-phase chromatid separation in Burkitt's lymphoma and nasopharyngeal carcinoma.
abstract: Chromosomes with various degrees of centromere spreading and completely separated chromatids, as well as metaphasic chromosomes, were observed simultaneously in the same Burkitt's lymphoma cell. In another study, a pair of prematurely and completely separated chromatids was found in a metaphase of nasopharyngeal carcinoma cell. Based on these and other observations, the possible significance of centromere spreading and out-of-phase sister chromatid separation in the origin of chromosome nondisjunction in tumor cells is suggested and discussed.
mesh_terms: D002051:Burkitt Lymphoma / Q000235:genetics*; D002277:Carcinoma / Q000235:genetics*; D002460:Cell Line; D002503:Centromere / Q000648:ultrastructure*; D002842:Chromatids / Q000648:ultrastructure*; D002875:Chromosomes / Q000648:ultrastructure*; D006801:Humans; D007621:Karyotyping; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*