title: Effect of sucralfate on the viscosity of gastric mucus and the permeability to hydrogen ion.
abstract: The effect of sucralfate on the viscosity of pig gastric mucus and on its ability to retard the diffusion of hydrogen ion was investigated. Using a cone/plate viscometer at shear rates between 1.15 and 230 s-1, it was found that preincubation of mucus with increasing concentrations of sucralfate led to a gradual enhancement of the mucus viscosity. This enhancement in viscosity was proportional to the sucralfate concentration up to 1.0 X 10(-4) M and increased about 18% for each 10-fold increment in its concentration. The permeability measurements, conducted in a specially designed two compartment chamber, revealed that addition of sucralfate to gastric mucus had a profound beneficiary effect on its ability to retard the diffusion of hydrogen ion. In the presence of 1.0 X 10(-6) M sucralfate the permeability of mucus to hydrogen ion decreased by 35%, while the 1.0 X 10(-3) M sucralfate reduced the mucus permeability by 68%. The results show that sucralfate increases the viscosity of gastric mucus and improves its ability to impede the hydrogen ion penetration.
mesh_terms: D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D004058:Diffusion; D005753:Gastric Mucosa / Q000378:metabolism*; D006859:Hydrogen / Q000378:metabolism*; D009093:Mucus / Q000187:drug effects* / Q000378:metabolism; D010539:Permeability; D013392:Sucralfate; D013552:Swine; D014783:Viscosity
chemical_list: D000897:Anti-Ulcer Agents; D013392:Sucralfate; D006859:Hydrogen; D000535:Aluminum