Post-anoxic delayed encephalopathy with leukoencephalopathy and non-hemorrhagic cerebral amyloid angiopathy.
A 74 year-old woman with an early-stage senile dementia developed severe hypertonia and akinetic mutism two weeks after exposure to methane. A CT scan showed a diffuse area of decreased density extending symmetrically into the white matter of both cerebral hemispheres. Neuropathology revealed a senile dementia, Alzheimer's type, with severe non-hemorrhagic cerebral amyloid angiopathy and a diffuse spotty demyelination of the cerebral hemispheres sparing the U fibers, corpus callosum and internal capsules. The close resemblance between Grinker's myelinopathy, secondary to CO exposure or to other non-CO anoxic causes, and the leukoencephalopathy associated with cerebral amyloid angiopathy is emphasized.
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology; D000686:Amyloidosis / Q000150:complications / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000150:complications / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000150:complications*; D008697:Methane / Q000506:poisoning
D008697:Methane