Detection of the hypercalcemic hormone of malignancy in an adrenal cortical carcinoma.
We report a case of an adrenal cortical carcinoma associated with hypercalcemia. Tumor extracts showed significant activity in an in vitro assay that detects the existence of a hypercalcemic substance distinct from parathyroid hormone. Calcium studies revealed no other obvious cause of hypercalcemia in this patient, and serum calcium returned to normal after the tumor was removed.
D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000378:metabolism*; D000328:Adult; D002277:Carcinoma / Q000150:complications / Q000378:metabolism*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism*; D044162:Parathyroid Hormone-Related Protein
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein