[Procedure for the biological testing of substances in the guinea pig subcutaneous test. II. The results of mathematical evaluation and modelling of the morphometric data on the area of reaction].
The extent of the reaction area around implanted materials (connective tissue capsule) was measured by the electronic device system Densitron and was represented in its temporal dependence after implantation. A histocompatibility index (referring to titanium as reference material) was deduced from the course of the connective tissue adaptation (healing in process). Linear regression calculation shows that the healing in process can be described very well by means of a power function for the most of the investigated materials. A clear demarcation and classification of the tissue tolerance of the different materials was managed for the histocompatibility index and also by the obvious integral values of the experimentally found out and mathematically modelled subsidence curves of the connective tissue reaction (selected period: 90th to the 200th day after the implantation).
D000818:Animals; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004343:Drug Implants / Q000633:toxicity*; D004582:Electronics, Medical / Q000295:instrumentation; D006168:Guinea Pigs; D007428:Intradermal Tests / Q000379:methods*; D008954:Models, Biological; D012044:Regression Analysis; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012882:Skin Tests / Q000379:methods*; D013997:Time Factors
D004343:Drug Implants
Verfahren zur biologischen Prüfung von Werkstoffen mit dem Subkutantest an Meerschweinchen. II. Ergebnisse der mathematischen Auswertung und Modellierung morphometrischer Daten aus der Reaktionszone.