Paradoxical effect of three-day thymectomy on sarcogenesis in the mouse with different dosages of methylcholanthrene.
Past studies have shown that thymectomy in the mouse at 3 days of age but not at birth or after 7 days produces, in later life, a variety of localized autoimmune lesions. In the present work, 3-day thymectomy facilitated subsequent sarcogenesis by low dosages of 3-methylcholanthrene but inhibited oncogenesis by a high dosage. If the presence of autoimmunity implies an increased antitumor immunity, it then follows that increased immunity facilitated low-dose sarcogenesis but inhibited sarcogenesis with a high dose.
D000367:Age Factors; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000276:immunology; D013934:Thymectomy
D008748:Methylcholanthrene