Vancomycin-induced neutropenia during treatment of osteomyelitis in an outpatient.
A case of vancomycin-associated neutropenia occurring during long-term outpatient therapy with vancomycin is described. Pharmacokinetic studies demonstrated that the patient's vancomycin serum levels were within an acceptable range during treatment. Eighteen other reported cases of vancomycin-associated leukopenia are discussed in brief. An immunologic mechanism has been proposed but a clear understanding is lacking. Patients receiving long-term vancomycin therapy should have their white blood cell counts periodically monitored.
D000380:Agranulocytosis / Q000139:chemically induced*; D000553:Ambulatory Care; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood / Q000139:chemically induced*; D010019:Osteomyelitis / Q000097:blood / Q000188:drug therapy*; D014640:Vancomycin / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use
D014640:Vancomycin