Sympathetic nervous system trophism for neuroblastoma and its age dependence in rats.
The sympathetic nervous system modulates the growth of C-1300 mouse neuroblastoma in vivo and in vitro. We now report that a mitogenic/trophic factor that augments growth of C-1300 neuroblastoma and of the S-20 neuroblastoma clonal line is present in freshly excised sympathetic cervical ganglia from newborn rats, but is not detectable in homogenates from sympathetic ganglia obtained from adult rats.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D006133:Growth Substances / Q000502:physiology; D009447:Neuroblastoma / Q000473:pathology*; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology*
D006133:Growth Substances