Motor neuron disease and plasma cell dyscrasia.
In the years 1977 to 1984, 10 of 206 patients (4.8%) with motor neuron disease (MND) had M proteins; 4 had IgM and 6 had IgG. Among 100 control patients with other neurologic diseases, only 1 had an M protein. We later added six cases of MND and M proteins, as well as three with polyclonal IgM elevations and two with Bence-Jones proteins. Including other reports, there are now 37 known cases of MND with monoclonal and 5 with polyclonal gammopathy. There is evidence that plasma cell dyscrasia is often undetected; the actual incidence of serum immunoglobulin abnormality in patients with MND may be greater than our figure.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons; D009133:Muscular Atrophy / Q000150:complications* / Q000175:diagnosis; D010265:Paraproteinemias / Q000150:complications* / Q000175:diagnosis
D006023:Glycoproteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C023587:protein M (glycoprotein)