RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D006224:Cricetinae; D004247:DNA / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006868:Hydrolysis; D000860:Hypoxia / Q000378:metabolism; D007700:Kinetics; D008920:Misonidazole / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D010084:Oxidation-Reduction; D011838:Radiation-Sensitizing Agents / Q000378:metabolism / Q000633:toxicity*; D013329:Structure-Activity Relationship; D014965:X-Rays
D011838:Radiation-Sensitizing Agents; C041712:1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol; D008920:Misonidazole; D004247:DNA; D005978:Glutathione