The protective effects of vitamin E against microcephaly in rats X-irradiated in utero: dendritic branches.
Fetuses from rats given either water or 0.03% dl-alpha-tocopherol acetate (vitamin E) as the drinking fluid and X-irradiated with 100R on gestational day (gd) 13 were examined on gd 21. The degree of dendritic branching of frontal cerebral neurons, examined after Golgi staining, was significantly reduced by X-irradiation, and supplementation of vitamin E caused increased branching order numbers in irradiated fetuses. This study provides evidence of the protection by vitamin E of neuronal development in X-irradiated fetuses.
D000016:Abnormalities, Radiation-Induced / Q000517:prevention & control*; D000818:Animals; D008831:Microcephaly / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E