CGS 8216, a novel anorectic agent, selectively reduces saccharin solution consumption in the rat.
The pyrazoloquinoline CGS 8216, a high-affinity ligand for benzodiazepine recognition sites, significantly reduced the consumption of a preferred 0.05% sodium saccharin solution in a 30 min two-bottle test. A highly significant effect was detected at 5.0 mg/kg, IP and at higher doses. The consumption of water and 0.6% saline, in two-bottle tests, or of quinine solution and water, in a forced-choice test, was not reliably affected by CGS 8216. The results point to a sensitive and selective intrinsic effect of CGS 8216 on ingestional responses in the rat.
D000818:Animals; D001067:Appetite Depressants; D005247:Feeding Behavior / Q000187:drug effects*; D005518:Food Preferences / Q000187:drug effects; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology*; D011803:Quinine; D051381:Rats; D012439:Saccharin; D012965:Sodium Chloride
D001067:Appetite Depressants; D011720:Pyrazoles; D012965:Sodium Chloride; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one; D011803:Quinine; D012439:Saccharin