title: Control of fungal sterol C-24 transalkylation: importance to developmental regulation.
abstract: When cultures of Gibberella fujikuroi are incubated with 24-epiiminolanosterol the introduction of a methyl group into sterol side chains at C-24 is blocked inducing a mycelial accumulation of lanosterol and 24-desalkylsterols, i.e., having the cholestane side chain. The altered sterol composition lead to aberrant mycelial membranes resulting in growth inhibition. A compensatory physiological response to the ensuing hyphal death was induction of asexual sporulation. The results are interpreted to imply that regulation of sterol C-24 transalkylation may be a mechanism to mediate life cycle events of fungi.
mesh_terms: D000478:Alkylation; D002849:Chromatography, Gas; D005874:Gibberella / Q000378:metabolism*; D006999:Hypocreales / Q000378:metabolism*; D007810:Lanosterol / Q000378:metabolism*; D008956:Models, Chemical; D013172:Spores, Fungal
chemical_list: D007810:Lanosterol