[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].
Clove oil injection in the anterior chamber of the rabbit eye produces an uveitis and a disruption of the blood-ocular barrier which can be evaluated by the leakage of 125I-radiolabelled rabbit serum albumin (RSA) administered intravenously. In the normal rabbit eye the amount of RSA in the aqueous humor is quite small. The disruption of the blood-ocular barrier by clove oil injection increases the RSA level in the anterior chamber of the eye. Topically applied chromocarb diethylamine reduces significantly the disruption of the blood-ocular barrier in the inflamed eye. Despite of its lack of anti-inflammatory activity, this compound, as a 10% eye-drop formulation, was shown nearly as effective as prednisolone 0.1%, in the corneal edema and the disruption of the blood-ocular barrier.
D000818:Animals; D002867:Chromones / Q000008:administration & dosage / Q000627:therapeutic use*; D004048:Diethylamines / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004338:Drug Combinations / Q000008:administration & dosage / Q000627:therapeutic use; D005054:Eugenol; D008297:Male; D009883:Ophthalmic Solutions; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D014605:Uveitis / Q000139:chemically induced / Q000188:drug therapy*
D002867:Chromones; D004048:Diethylamines; D004338:Drug Combinations; D009883:Ophthalmic Solutions; D005054:Eugenol; D011239:Prednisolone; C031334:chromocarb diethylamine
Effets du chromocarbe diéthylamine et de la prednisolone sur l'uvéite expérimentale à l'essence de girofle chez le lapin.