PD 113,618 and PD 118,309, new pactamycin analogs.
Two antibiotics were isolated from culture broths of a Streptomyces sp. and identified as 8"-hydroxypactamycin and 7-deoxypactamycin. The latter antibiotic was shown to be identical to cranomycin. An additional compound, 8"-hydroxypactamycate, was also isolated.
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D010142:Pactamycin / Q000031:analogs & derivatives / Q000302:isolation & purification*; D013302:Streptomyces / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; C049988:8''-hydroxypactamycin; C049987:cranomycin; D010142:Pactamycin