Experimental evidence for the probable involvement of calcium ion transport in 67Ga uptake by tumour cells.
The study of 67Ga-citrate uptake and calcium transport in Ehrlich ascites tumour cells seems to indicate that their peculiar characteristic of increased permeability to extracellular calcium ion might be responsible for their 67Ga accumulation. Experiments performed under different conditions of extracellular calcium, temperature, and presence of ionophore and other plasma membrane modifying agents such as lanthanum appear to corroborate this hypothesis.
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D002286:Carcinoma, Ehrlich Tumor / Q000000981:diagnostic imaging* / Q000378:metabolism; D005710:Gallium Radioisotopes / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D011877:Radionuclide Imaging; D013696:Temperature
D005710:Gallium Radioisotopes; D002118:Calcium