Frequency of aminoglycoside 6'-N-acetyltransferase among Serratia species during increased use of amikacin in the hospital.
The incidence of tobramycin-resistant, gentamicin-susceptible Serratia species at the Minneapolis Veterans Administration Medical Center decreased from an average 42.1 to 2.5% (P less than 0.001) during a 4.5-year period despite the predominant use of amikacin. These organisms were shown to express a 6'-N-acetyltransferase-modifying enzyme (EC 2.3.1.82). Resistance was not shown to be plasmid mediated.
D000123:Acetyltransferases / Q000032:analysis*; D000583:Amikacin / Q000494:pharmacology* / Q000627:therapeutic use; D004269:DNA, Bacterial / Q000378:metabolism; D004363:Drug Utilization; D005839:Gentamicins / Q000494:pharmacology; D007612:Kanamycin / Q000031:analogs & derivatives*; D008826:Microbial Sensitivity Tests; D012705:Serratia / Q000187:drug effects / Q000201:enzymology*; D013997:Time Factors; D014031:Tobramycin / Q000494:pharmacology
D004269:DNA, Bacterial; D005839:Gentamicins; D007612:Kanamycin; D000583:Amikacin; D000123:Acetyltransferases; C019681:aminoglycoside acetyltransferase; D014031:Tobramycin