[Binding of cardiac glycosides by the erythrocytes of patients].
Digoxin and strophanthin K uptake by patients' red cells was investigated by the Rb-86 assay. It was found that digoxin and strophanthin K levels in red cells increased with augmentation of the drugs concentrations in plasma, the ratio of cardiac glycoside levels in red cells to their concentrations in plasma decreased. The degree of binding to red cells is more pronounced for strophanthin K than for digoxin.
D000328:Adult; D002301:Cardiac Glycosides / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood / Q000188:drug therapy; D006801:Humans; D008943:Mitral Valve; D012214:Rheumatic Heart Disease / Q000097:blood / Q000188:drug therapy; D013997:Time Factors
D002301:Cardiac Glycosides
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