The presence of Müllerian remnants in the complete androgen insensitivity syndrome: a steroid hormone-mediated defect?
A new patient with CAIS who presented Müllerian remnants has been described. Based on recently reported data in experimental animals and considering that human embryos carrying the X-linked CAIS mutation do not express any androgenic effect, we propose that the unopposed estrogenic action in the CAIS-developing embryo might interfere with the mechanism of action of the AMH inhibiting the regression of the female ducts.
D000328:Adult; D003600:Cytosol / Q000032:analysis; D012734:Disorders of Sex Development / Q000235:genetics / Q000473:pathology*; D004967:Estrogens / Q000502:physiology; D005187:Fallopian Tubes / Q000473:pathology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009095:Mullerian Ducts / Q000473:pathology*; D010641:Phenotype; D011944:Receptors, Androgen / Q000032:analysis / Q000235:genetics; D013577:Syndrome; D013737:Testis / Q000473:pathology
D004967:Estrogens; D011944:Receptors, Androgen