Synthesis of the potent mutagen 3,5,8-trimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine.
The mutagenic title compound (5,8-DiMeIQx) was synthesized by two different routes: from 2-methyl-4,6-dinitroaniline; and from 4-chloro-2-methyl-6-nitroaniline. The latter and more convenient route involved 2,1,3-benzoselenadiazole intermediates.
D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009153:Mutagens / Q000138:chemical synthesis*; D011810:Quinoxalines / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D009153:Mutagens; D011810:Quinoxalines; C048764:3,5,8-trimethylimidazo(4,5-f)quinoxalin-2-amine