[Double-blind study with cyclosporin A eyedrops in healthy probands].
Cyclosporin-A eye drops initiate an immunosuppression after corneal transplantation in rabbits as well as in humans, as experimental and clinical studies showed. A tolerance study with 12 volunteers (healthy and without any ophthalmological disease) was designed as a randomized double-blind study. Apart from two objectively slight intolerance reactions there were no side-effects. The use of these drops after corneal transplantation is discussed.
D000328:Adult; D003228:Conjunctiva / Q000187:drug effects; D003315:Cornea / Q000187:drug effects*; D003524:Cyclosporins / Q000378:metabolism / Q000633:toxicity*; D004311:Double-Blind Method; D005143:Eyelids / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions; D013666:Tears / Q000378:metabolism
D003524:Cyclosporins; D009883:Ophthalmic Solutions
Doppelblindstudie mit Cyclosporin-A-Augentropfen an gesunden Probanden.