An autopsy case of dementia and parkinsonism with severe degeneration exclusively in the substantia nigra.
We have recently encountered a patient with progressive dementia and parkinsonism beginning at the age of 68 years and developing for 2 years. Pathological examination revealed severe degeneration exclusively in the substantia nigra with absence of Lewy bodies and neurofibrillary changes. The features of this case are reported and discussed.
D000368:Aged; D001344:Autopsy; D001921:Brain / Q000473:pathology; D003704:Dementia / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D009410:Nerve Degeneration; D010300:Parkinson Disease / Q000150:complications / Q000473:pathology*; D013378:Substantia Nigra / Q000473:pathology*