Oro-facial granulomatosis. Response to elemental diet and provocation by food additives.
We report the case of an 8.5-year-old girl with oro-facial granulomatosis associated with clinical atopy, in whom relapse of her granulomatous disorder was shown to be related to exposure to specific food additives, viz. carmoisine, sunset yellow and monosodium glutamate. Treatment with a restricted diet resulted in considerable regression in the facial swelling which has been maintained for 6 months. A brief account of the histological features, both under light and electron microscopy, is given, together with a description of the use of nuclear magnetic resonance scanning in the assessment of this disease. The patient had no evidence to support a diagnosis of sarcoidosis or Crohn's disease.
D002648:Child; D005145:Face / Q000473:pathology; D005260:Female; D005503:Food Additives / Q000009:adverse effects* / Q000627:therapeutic use; D005512:Food Hypersensitivity / Q000178:diet therapy / Q000276:immunology; D006105:Granulomatous Disease, Chronic / Q000139:chemically induced / Q000178:diet therapy* / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000188:drug therapy / Q000276:immunology; D009055:Mouth / Q000473:pathology; D009282:Naphthalenesulfonates / Q000009:adverse effects; D009930:Organic Chemicals; D012970:Sodium Glutamate / Q000009:adverse effects; D013025:Glycine max
D005503:Food Additives; D009282:Naphthalenesulfonates; D009930:Organic Chemicals; C011567:Vivonex; C006671:azo rubin S; D012970:Sodium Glutamate