[The influence of the small intestine on the metabolism of 3-methylhistidine in the rat].
20 male adult Sprague-Dawley rats were fed exclusively parenterally. After achieving metabolic equilibrium they received a duodenoileostomy and subtotal resection leaving only 8-10% of the small gut. On the 1st pop. day the urinary 3-MH excretion rose to 1.5-1.7 of the preoperative level, but on the 12th-14th pop. day it fell again and was equal to the preoperative basal level. A control group of 10 rats undergoing a small gut anastomosis without resection yielded similar results. We conclude that the small gut source does not make a significant contribution to 24 h-urinary 3-MH excretion in the adult rat. The transient postoperative increase in urinary 3-MH excretion is probably due to post-injury metabolism.
D000818:Animals; D006639:Histidine / Q000031:analogs & derivatives*; D007421:Intestine, Small / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008762:Methylhistidines / Q000378:metabolism* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
D008762:Methylhistidines; D006639:Histidine; C028118:3-methylhistidine
Einfluss des Dünndarms auf den Stoffwechsel von 3-Methylhistidin der Ratte.