[Nature of non-adrenergic inhibition in the smooth muscles of the human intestine].
Electrical responses of longitudinal and circular smooth muscles of human small intestine and colon to ATP, alpha, beta-methylene-ATP, beta, gamma-methylene-ATP and adenosine were studied by the sucrose-gap method. In most cases ATP induced the effect similar to that of stimulation of the nonadrenergic inhibitory nerves. Desensitization of the purinergic receptors by alpha, beta-methylene-ATP selectively decreased the amplitude of inhibitory junction potentials. The results confirm the purinergic hypothesis of the nonadrenergic inhibition in human intestine.
D000241:Adenosine / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects; D007422:Intestines / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009433:Neural Inhibition; D011955:Receptors, Drug / Q000187:drug effects; D000254:Sodium-Potassium-Exchanging ATPase
D011955:Receptors, Drug; C028996:cardiac glycoside receptors; C005147:5'-adenylyl (beta,gamma-methylene)diphosphonate; D000255:Adenosine Triphosphate; D000254:Sodium-Potassium-Exchanging ATPase; D000241:Adenosine; C002630:alpha,beta-methyleneadenosine 5'-triphosphate
Priroda neadrenergicheskogo tormozhaniia v gladkikh myshtsakh kishechnika cheloveka.