Absorption of carbonyl iron.
The mechanism of carbonyl iron absorption has been studied in rats. Solubilization by gastric acid was a prerequisite for subsequent absorption. The slow rate of solubilization resulted in a more prolonged absorption, responsible for the low toxicity of carbonyl iron. Large doses of carbonyl iron were held for several days by the gastric mucosa of iron-deficient animals. Once it had been solubilized, the subsequent pathway of absorption by the intestinal mucosa and the amount absorbed was similar to that of ferrous ammonium sulfate.
D000818:Animals; D005296:Ferrous Compounds / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption; D007501:Iron / Q000378:metabolism*; D054354:Iron Carbonyl Compounds; D008297:Male; D009942:Organometallic Compounds; D000644:Quaternary Ammonium Compounds / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility
D005296:Ferrous Compounds; D009942:Organometallic Compounds; D000644:Quaternary Ammonium Compounds; D054354:Iron Carbonyl Compounds; C038178:ammonium ferrous sulfate; D007501:Iron