Increased intestinal permeability in atopic eczema.
We have investigated gastrointestinal permeability in children with atopic eczema by measuring the relative urinary excretion rates of the inert di- and monosaccharides lactulose and rhamnose following their oral administration. The median lactulose/rhamnose ratio was greater in 26 children with atopic eczema than in a control group of 29 children which included both healthy individuals and others with various noneczematous dermatoses. This increased permeability may be a primary abnormality of the gut or may reflect intestinal mucosal damage caused by local hypersensitivity reactions to food antigens.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000378:metabolism*; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications; D005767:Gastrointestinal Diseases / Q000209:etiology; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000378:metabolism*; D007792:Lactulose / Q000378:metabolism; D008297:Male; D010539:Permeability; D012210:Rhamnose / Q000378:metabolism
D007792:Lactulose; D012210:Rhamnose