Effect of simultaneous exposure to nickel chloride and benzo(a)pyrene on developing chick embryos.
In the present investigation the effect of Benzo(a)pyrene (BP) and Nickel chloride, quite often identified in crude and refined or waste oil, when injected in combination, was investigated on developing chick embryos after exposing them through yolk sac route on 6th day of incubation. Exposure to this combination in different doses resulted in no new deformities other than those experienced in BP treated chick embryos. The mortality and malformations experienced in the chick embryos exposed to BP alone and NiCl2 alone were seen to be added when both the chemicals were simultaneously inoculated into the same chick eggs.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D002642:Chick Embryo; D004347:Drug Interactions; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D009532:Nickel / Q000633:toxicity*
D001564:Benzo(a)pyrene; C022838:nickel chloride; D009532:Nickel