Selective lesions of mesostriatal dopamine neurons ameliorate hypoglycemic damage in the caudate-putamen.
Unilateral 6-hydroxydopamine lesion of the mesostriatal dopaminergic system was found to ameliorate neuronal necrosis in the caudate-putamen following 30 min of insulin-induced hypoglycemic coma. We propose that increased release of dopamine in the striatum during hypoglycemia or in the recovery period potentiates a deleterious neuronal hyperexcitation, probably induced by excessive release of glutamate or related compounds, thereby aggravating neuronal necrosis.
D000818:Animals; D002421:Caudate Nucleus / Q000473:pathology*; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000502:physiology*; D006892:Hydroxydopamines / Q000494:pharmacology; D007003:Hypoglycemia / Q000473:pathology*; D007331:Insulin Coma / Q000473:pathology*; D008297:Male; D009409:Nerve Crush; D009410:Nerve Degeneration; D009474:Neurons / Q000502:physiology; D011699:Putamen / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains
D006892:Hydroxydopamines; D004298:Dopamine