[Use of immunoglobulin for treating patients with nonspecific ulcerative colitis].
The therapeutic effect of human immunoglobulins was assessed in 29 patients with nonspecific ulcerative colitis, as was their influence on intestinal flora. A 5 to 15 ml dose of immunoglobulin was administered intramuscularly every other day, 3 injections altogether. The clinical and endoscopic effect of treatment was positive in 21 patients (72.4%). Large-intestinal mucosal imprints were studied histologically in 17 patients. Inflammation subsided in 11 patients (64.7%), and glandular epithelial proliferation declined in 4 (23.5%). In the course of treatment, lactobacilli, and bifidobacteria were considerably increased in number, while opportunity organisms were decreased, a possible cause of the positive clinical effect.
D000328:Adult; D001419:Bacteria / Q000302:isolation & purification; D003093:Colitis, Ulcerative / Q000382:microbiology / Q000628:therapy*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007422:Intestines / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
Primenenie immunoglobulina dlia lechenii bol'nykh nespetsificheskim iazvennym kolitom.