Ectopic calcification in hypophosphatasia.
The radiological findings in a 24 year old female with hypophosphatasia included frayed joint surfaces, intra- and peri-articular, and paravertebral calcification. These changes were compared to the usual radiographic findings in hypophosphatasia and prompted a family study. Excessive spinal osteophytosis and/or chondrocalcinosis was a relatively frequent finding in the relatives and it is suggested that these changes might indicate the heterozygous state.
D000293:Adolescent; D000328:Adult; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000209:etiology*; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006801:Humans; D007014:Hypophosphatasia / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011859:Radiography