Beta-adrenoceptor blocking drugs and cytochrome P-450: the influence of propranolol treatment on caffeine, antipyrine, D-glucaric acid and indocyanine green elimination in patients with hepatic disorders.
The effect of the beta-adrenoceptor blocking drug propranolol was investigated in patients with alcoholic liver disease and in those without liver disease before and after ten days treatment with 80 mg daily. Caffeine as a marker drug for the 3-methylcholanthrene-inducible subtype had a significantly enhanced clearance after propranolol in liver-diseased patients, while the clearance of antipyrine which represents the phenobarbital-inducible subtype was unchanged. D-glucaric acid excretion as an endogenous compound which serves as an indicator of induced state of drug-metabolizing capacity of the liver was slightly enhanced in liver patients, but significantly decreased in patients without liver disorders. Indocyanine green elimination as a test material for substances limiting liver blood flow was not significantly reduced by this propranolol dosage.
D000328:Adult; D000983:Antipyrine / Q000378:metabolism; D002110:Caffeine / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005260:Female; D005937:Glucaric Acid / Q000378:metabolism; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism; D008108:Liver Diseases, Alcoholic / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000494:pharmacology*
D002110:Caffeine; D003577:Cytochrome P-450 Enzyme System; D011433:Propranolol; D007208:Indocyanine Green; D005937:Glucaric Acid; D000983:Antipyrine