title: Globin genes in Polynesians have many rearrangements including a recently described gamma gamma gamma gamma/.
abstract: Rearrangements involving genes of the alpha- and beta-globin loci were frequently detected in DNA from Polynesians. A founder effect and genetic drift occurring 2,000-3,000 years ago as Polynesians migrated eastward across the Pacific is proposed as the likely mechanism for these genetic changes that include deletions or additions of alpha-, gamma-, and zeta-globin genes and an unusual restriction fragment length polymorphism (RFLP) associated with the zeta gene. Preliminary data show different frequencies for gene rearrangements between island groups. Further study of these differences should provide additional information on the prehistory of Polynesians.
mesh_terms: D002874:Chromosome Mapping; D005828:Genetics, Population; D005914:Globins / Q000235:genetics*; D006801:Humans; D010375:Pedigree; D011114:Polynesia; D013789:Thalassemia / Q000235:genetics
chemical_list: D005914:Globins