title: [Dynamics of the anti-anginal effect and of the concentrations of verapamil and its metabolites in the blood serum of patients with stenocardia of exertion].
abstract: Anti-anginal effect of verapamil was examined in 17 patients with angina of effort (a 120 mg single dose in 10 patients and a 200 mg dose in 7), using repeated identical treadmill exercise with ECG monitoring. Serum levels of verapamil and its three primary metabolites were measured simultaneously. A correlation was demonstrated between verapamil's anti-ischemic effect and serum concentrations, while no significant contribution of the metabolites to the effect could be shown. In most patients, a marked anti-ischemic effect was observed where blood levels of verapamil exceeded 100 ng/ml. A considerable variability was noted in both the maximum concentrations of the drug and its individual concentrations corresponding to the same anti-anginal effect.
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D013997:Time Factors; D014700:Verapamil / Q000031:analogs & derivatives / Q000097:blood / Q000627:therapeutic use*
chemical_list: C016904:norverapamil; D014700:Verapamil
vernacular_title: Dinamika antianginal'nogo éffekta i kontsentratsiĭ verapamila i ego metabolitov v syvorotke krovi u bol'nykh so stenokardieĭ napriazheniia.