Influence of delta-sleep inducing peptide on melatonin synthesis in the rat pineal gland.
The influence of delta-sleep inducing peptide (DSIP) on rat pineal N-acetyltransferase (NAT) activity and melatonin levels was examined. Young adult rats received an injection of either saline or DSIP (either 15, 30 or 60 nmol/kg) at 20:00 h, immediately before lights out. DSIP at a dose of 15 nmol/kg significantly retarded the nighttime rise of pineal NAT activity and melatonin levels at 3 h into the dark phase. At the other two nocturnal time points (01:00 and 03:00 h) and the following morning (08:00 h) pineal NAT activity and melatonin levels were similar in all groups. The results confirmed a short-lived, dose-specific effect of DSIP on serotonin metabolism in the rat pineal gland.
D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000378:metabolism; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D008027:Light; D008297:Male; D008550:Melatonin / Q000096:biosynthesis*; D010870:Pineal Gland / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013997:Time Factors
D012701:Serotonin; D003701:Delta Sleep-Inducing Peptide; D001191:Arylamine N-Acetyltransferase; D008550:Melatonin