Epinephrine, norepinephrine, and isoproterenol dose-outflow facility response relationships in cynomolgus monkey eyes with and without ciliary muscle retrodisplacement.
Intracameral slowly mixed bolus doses of 10 micrograms of 1-epinephrine or 1-norepinephrine bitartrate significantly increased total outflow facility by similar percentages in ciliary muscle disinserted and non-disinserted living cynomolgus monkey eyes (approximately 20% for epinephrine, 30% for norepinephrine); smaller or larger bolus doses (0.1, 1, 50 micrograms) either had no effect or tended to decrease facility. Bolus doses of dl-isoproterenol sulphate (0.1, 0.2, 10, 50 micrograms) or 1-isoproterenol hydrochloride (0.1, 1, 10 micrograms) had no effect in either type of eye. Rapidly mixed relatively maintained intracameral concentrations of dl(0.1, 1 micrograms/ml)- or l(0.1, 1, 10 micrograms/ml)-isoproterenol had no effect in surgically untouched eyes. All catecholamine solutions were stable under the experimental conditions.
D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects; D001082:Aqueous Humor / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000008:administration & dosage*; D005260:Female; D007498:Iris / Q000502:physiology; D007545:Isoproterenol / Q000008:administration & dosage*; D008252:Macaca fascicularis; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage*; D009801:Oculomotor Muscles / Q000187:drug effects* / Q000502:physiology
D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine