title: [Concentration of benzonal in the blood of epileptic patients at different daily doses and with other anticonvulsants].
abstract: A study involving 36 epileptic patients and 8 control subjects was devoted to the optimization of antiepileptic drug therapy with the help of determining the blood levels of anticonvulsants (benzonal, phenobarbital). The daily dose of an anticonvulsant directly correlated with its blood levels. Blood levels of benzonal increased upon the additional administration to patients of hexamidine or hexamidine and diphenylhydantoin mixtures. A reduction in the daily dose of benzonal by 2/3 was attended by a 50% decline in its blood levels.
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage*; D001463:Barbiturates / Q000008:administration & dosage / Q000097:blood*; D001550:Benzamidines / Q000008:administration & dosage; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage / Q000031:analogs & derivatives; D010672:Phenytoin / Q000008:administration & dosage
chemical_list: D000927:Anticonvulsants; D001463:Barbiturates; D001550:Benzamidines; C018961:hexamidine; D010672:Phenytoin; C002915:benzobarbital; D010634:Phenobarbital
vernacular_title: Kontsentratsiia benzonala v krovi bol'nykh épilepsieĭ pri raznykh sutochnykh dozakh i prieme drugikh antikonvul'santov.