Structure activity relationship in heparin: stimulation of non-vascular cells by a synthetic heparin pentasaccharide in cooperation with human acidic fibroblast growth factors.
Heparin enhances strongly the mitogenic properties of human acidic fibroblast growth factor (h-aFGF) on hamster fibroblast (CCL 39) or bovine lens epithelial cells (BEL). We report here that a synthetic heparin pentasaccharide with high affinity for antithrombin III has the same effect as heparin at about the same concentration. Thus a pentasaccharidic sequence may represent the shortest heparin structure which interacts with h-aFGF.
D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D002240:Carbohydrate Sequence; D002417:Cattle; D002460:Cell Line; D006224:Cricetinae; D004848:Epithelium / Q000187:drug effects; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects; D013329:Structure-Activity Relationship
D005346:Fibroblast Growth Factors; D000990:Antithrombin III; D006493:Heparin