The cholecystokinin-like peptide, ceruletide, reduces isolation-induced aggression in mice.
Ceruletide, a non-mammalian decapeptide related to cholecystokinin octapeptide, reduced the aggressiveness of isolated NMRI mice. In this respect, its ED50 (mumol/kg, s.c.) was 0.024 (95% confidence range, 0.0133-0.0447) and that of haloperidol 3.38 (1.488-7.669). An approximately equipotent dose of diazepam was 17.5 mumol/kg.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D002108:Ceruletide / Q000494:pharmacology*; D003864:Depression, Chemical; D003975:Diazepam / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051379:Mice; D012934:Social Isolation
D002108:Ceruletide; D006220:Haloperidol; D003975:Diazepam