Propionate metabolism and its regulation by fatty acids in ovine hepatocytes.
Propionate metabolism was studied in ovine hepatocytes. The main products of metabolism were CO2, glucose, L-lactate and pyruvate. The fatty acids, butyrate and palmitate inhibited propionate oxidation; butyrate inhibited but palmitate slightly stimulated gluconeogenesis from propionate. Butyrate and palmitate also inhibited lactate and pyruvate production from both endogenous substrates and from propionate.
D000818:Animals; D001692:Biological Transport; D002087:Butyrates / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D002478:Cells, Cultured; D005943:Gluconeogenesis; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000494:pharmacology*; D011422:Propionates / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism; D012756:Sheep
D002087:Butyrates; D002250:Carbon Radioisotopes; D007773:Lactates; D010169:Palmitic Acids; D011422:Propionates; D011773:Pyruvates; D019308:Palmitic Acid