[Experimental cancerogenesis. Stimulation of ornithine decarboxylase of the colonic mucosa in vitamin A-deficient rats by sodium desoxycholate].
During a state of pure vitamin A deficiency, without any clinical manifestations, in colonic mucosa: ornithine decarboxylase activity is already stimulated, in deficient animals, by instillation of NaCl 9%. Sodium deoxycholate further enhances and markedly protracts the enzyme activity, as compared to normal rats. These results lead to the conclusion that vitamin A deficiency is a state of special sensibility to the promoter action. Retinol is hence physiologically necessary for natural resistance of intestinal cells against chemically induced tumor promotion.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003106:Colon / Q000201:enzymology*; D003110:Colonic Neoplasms / Q000201:enzymology / Q000209:etiology; D003840:Deoxycholic Acid / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D007413:Intestinal Mucosa / Q000201:enzymology*; D008297:Male; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D014802:Vitamin A Deficiency / Q000201:enzymology*
D003840:Deoxycholic Acid; D009955:Ornithine Decarboxylase
Cancérogenèse expérimentale. Stimulation de l'ornithine décarboxylase de la muqueuse colique chez le rat carencé en vitamine A par le désoxycholate de sodium.