[Possible mutagenic action of a tularemia vaccine].
No increase in the number of chromosome aberrations in the bone marrow cells of the Wistar rats was observed on the 1st, 2nd, 7th and 15th days after epidermal and intradermal immunization by tularemic live vaccine. Subcutaneous injection of great quantities of tularemic microbic cells which were not used in practice increased the number of cells with chromosome aberrations only on the second day.
D000818:Animals; D001428:Bacterial Vaccines / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations; D005260:Female; D005604:Francisella tularensis / Q000276:immunology*; D007114:Immunization; D008297:Male; D008677:Metaphase / Q000187:drug effects; D009153:Mutagens; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001428:Bacterial Vaccines; D009153:Mutagens
O vozmozhnom mutagennom deĭstvii tuliaremiĭnoĭ vaktsiny.