Biotransformation of diphenyl ether by trout and guinea-pigs after intraperitoneal administration.
Diphenyl ether (DPE) was administered intraperitoneally to rainbow trout (Salmo gairdneri) and guinea-pigs (Duncan Hartley). DPE metabolites in the urine and bile of trout and the urine of guinea-pigs were isolated and analysed by g.l.c.-mass spectrometry. No unchanged DPE was found in the biological fluids of guinea-pigs and trout. Only conjugated metabolites of DPE were present in the bile and urine of the trout: 4-hydroxy- and possible 3-hydroxy-DPE conjugates were found in the bile whereas 4-hydroxy- and 4,4-dihydroxy-DPE conjugates were detected in the urine. Both free and conjugated metabolites of DPE were isolated from the urine of guinea-pigs. These metabolites were 2-hydroxy-, 4-hydroxy, 4,4'-dihydroxy-, 4-methoxy-monohydroxy- and methoxy-dihydroxy-derivatives of DPE.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002849:Chromatography, Gas; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D008297:Male; D013058:Mass Spectrometry; D010647:Phenyl Ethers / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D013045:Species Specificity; D014337:Trout
D010647:Phenyl Ethers; C031538:phenyl ether