title: Effect of intrathecal and intracarotid administration of ketamine on blood pressure and heart rate in rats.
abstract: Intrathecal and intracarotid effects of ketamine were investigated in anaesthetized rats. Ketamine was administered in the subarachnoid space in doses ranging from 300 to 1500 micrograms X kg-1. In these doses ketamine produced a short-lasting hypotension and bradycardia which may be due to inhibition of sympathetic outflow from thoraco-lumbar region. On the other hand when ketamine (5 mg X kg-1) was injected into the cerebral circulation it produced a rise in blood pressure and heart rate, probably through a cholinergic mechanism.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002339:Carotid Arteries; D002404:Catheterization; D003975:Diazepam / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D007267:Injections; D007269:Injections, Intra-Arterial; D007278:Injections, Spinal; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013346:Subarachnoid Space
chemical_list: D007649:Ketamine; D003975:Diazepam