[Immunosuppressor role of staphylococcal protein A].
The removal of protein A from the surface of staphylococci by means of proteolytic enzymes increases the immunogenic properties of staphylococci. Staphylococci containing protein A are less effective in mediating the immunological memory than those treated with proteolytic enzymes. The conjugation of protein A with staphylococci treated with proteolytic enzymes leads to the decrease of the immunogenic properties of staphylococci. Protein A not bound to staphylococci also suppresses antistaphylococcal immune response. The protective properties of corpuscular staphylococcal antigen are increased after the removal of protein A from the surface of staphylococci by proteolysis.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000921:Antibody-Producing Cells / Q000276:immunology; D007108:Immune Tolerance / Q000187:drug effects*; D007114:Immunization; D007156:Immunologic Memory / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology; D013205:Staphylococcal Protein A / Q000276:immunology* / Q000302:isolation & purification; D013209:Staphylococcal Vaccines / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology
D000907:Antibodies, Bacterial; D013205:Staphylococcal Protein A; D013209:Staphylococcal Vaccines
Immunosupressornaia rol' belka A stafilokokka.