Efficacy of parvaquone and long-acting oxytetracycline in Theileria annulata infection.
Therapeutic and prophylactic efficacies of parvaquone and long-acting oxytetracycline were tested against Theileria annulata infection, induced by injecting a suspension of infected ground tick tissues (GUTS) into groups of 4 or 5 calves. This infection killed two of four control calves, while all the animals given a single intramuscular dose of 20 mg kg-1 parvaquone or long-acting oxytetracycline on the day of infection underwent mild reactions and recovered. Two separate doses of parvaquone of 10 mg kg-1 administered on the first and second days of fever protected four out of five calves. All the recovered animals from both treated and control groups resisted a homologous challenge with GUTS on Day 45 post-infection which killed three out of four susceptible unimmunized control calves.
D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D002417:Cattle; D008297:Male; D009285:Naphthoquinones / Q000627:therapeutic use*; D010118:Oxytetracycline / Q000627:therapeutic use*; D013801:Theileriasis / Q000188:drug therapy*; D013987:Ticks
D000981:Antiprotozoal Agents; D009285:Naphthoquinones; C028032:parvaquone; D010118:Oxytetracycline