Splanchnic nerve transection abolishes the age-dependent increase of neuropeptide Y-like immunoreactivity in rat adrenal gland.
Using an antiserum directed against porcine neuropeptide Y (NPY), a high concentration of NPY immunoreactivity (NPY-IR) was detected in rat adrenal gland. The level of NPY-IR in the adrenal gland was found to increase considerably with age. Biochemical characterization by reverse-phase HPLC indicated that this increase was due to accumulations of NPY and another molecular form of NPY-like immunoreactive peptide. Chronic denervation of the splanchnic nerve abolished this age-dependent increase of NPY-IR rat adrenal gland.
D000311:Adrenal Glands / Q000378:metabolism*; D000375:Aging; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003714:Denervation; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009478:Neuropeptide Y; D051381:Rats; D011919:Rats, Inbred Strains; D013153:Splanchnic Nerves / Q000502:physiology*
D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y