title: Immunomodulation by tamoxifen and pergolide.
abstract: Treatment of rats with tamoxifen citrate or pergolide mesylate was as effective in inhibiting antibody formation and contact sensitivity skin reactions as was hypophysectomy. The immunocompetence of tamoxifen citrate- and pergolide mesylate-suppressed animals could be fully restored by additional treatment with prolactin or growth hormone.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003864:Depression, Chemical; D003877:Dermatitis, Contact / Q000276:immunology; D018492:Dopamine Antagonists; D004965:Estrogen Antagonists / Q000494:pharmacology; D004967:Estrogens / Q000502:physiology; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects*; D007165:Immunosuppression Therapy; D010479:Pergolide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011388:Prolactin / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D013629:Tamoxifen / Q000037:antagonists & inhibitors / Q000494:pharmacology*
chemical_list: D018492:Dopamine Antagonists; D004965:Estrogen Antagonists; D004967:Estrogens; D013629:Tamoxifen; D010479:Pergolide; D011388:Prolactin; D013006:Growth Hormone