[Action of nonachlazine on the creatine phosphokinase and acid phosphatase activity and on the lysosomal membrane stability of the ischemic myocardium in rats after preliminary reserpinization].
Experiments on the ischemic myocardial tissue of the rat in vitro showed that despite the fact that reserpine-induced depletion of the tissue catecholamine storage failed to affect the stability of lysosomal membranes, a combination of reserpine pretreatment of the animals with subsequent administration of nonachlazine at the low dose yielded stabilization of lysosomal membranes to a greater extent than administration of nonachlazine alone. The effects of nonachlazine (0.25 mg/kg) on the activity of creatine phosphokinase and total activity of acid phosphatase with and without reserpine pretreatment were similar.
D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000201:enzymology; D003402:Creatine Kinase / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects* / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D009628:Nonachlazine / Q000627:therapeutic use*; D010640:Phenothiazines / Q000627:therapeutic use*; D051381:Rats; D012110:Reserpine / Q000627:therapeutic use*; D013997:Time Factors
D010640:Phenothiazines; D009628:Nonachlazine; D012110:Reserpine; D003402:Creatine Kinase; D000135:Acid Phosphatase
Deĭstvie nonakhlazina na aktivnost' kreatinfosfokinazy, kisloĭ fosfatazy i stabil'nost' lizosomnykh membran ishemizirovannogo miokarda krys posle predvaritel'noĭ rezerpinizatsii.