K-252a, a potent inhibitor of protein kinase C from microbial origin.
K-252a, a metabolite isolated from the culture broth of Nocardiopsis sp. K-252a, was found to exhibit an extremely potent inhibitory activity on protein kinase C. The IC50 value was 32.9 nM.
D000192:Actinomycetales / Q000378:metabolism; D000818:Animals; D001419:Bacteria / Q000187:drug effects; D002147:Calmodulin / Q000037:antagonists & inhibitors; D002227:Carbazoles / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D026121:Indole Alkaloids; D051379:Mice; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*
D002147:Calmodulin; D002227:Carbazoles; D026121:Indole Alkaloids; D010726:Phosphodiesterase Inhibitors; C049985:staurosporine aglycone; D011493:Protein Kinase C