Intraventricular arginine vasopressin blocks the acquisition of ethanol tolerance in mice.
Intracerebroventricular administration of [Arg8]vasopressin (AVP) blocks the development of tolerance to ethanol, when ethanol is administered to mice in a learning paradigm. This effect appears to result from an influence of AVP on both functional and dispositional components of tolerance.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007276:Injections, Intraventricular; D007858:Learning / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D006993:Hypnotics and Sedatives; D001127:Arginine Vasopressin; D000431:Ethanol