Antibodies to brain proteins in paraneoplastic cerebellar degeneration.
A 68-year-old man had subacute cerebellar degeneration and a non-Hodgkin's lymphoma. Using an immunoblotting method, we found serum antibodies to rat cerebral 250-kd and 110-kd and cerebellar 110-kd acidic cytoplasmic proteins. The antibodies did not react unless the antigens were prepared soon after death with protease inhibitors. Two hundred fifty-kd and 110-kd proteins are minor components of soluble cytoplasmic proteins of the brain. The molecular weights differed from other soluble brain-specific proteins already characterized.
D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D002526:Cerebellar Diseases / Q000276:immunology*; D006801:Humans; D008223:Lymphoma / Q000276:immunology; D008297:Male; D009419:Nerve Tissue Proteins / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000276:immunology*
D001323:Autoantibodies; D009419:Nerve Tissue Proteins