Toxicity of 2-methyl-4-chlorophenoxyacetic acid to the adult crested newt.
The toxicity of the herbicide Agroxone 3, a commercial formulation of the sodium salt of 2-methyl-4-chlorophenoxyacetic acid (MCPA), in the adult newt (Triturus cristatus carnifex) was tested after percutaneous exposure. At the concentration of 3200 ppm, the LT50 values were 17 and 21 hr for male and female newts. At 1600 ppm, the LT50 values were 35 and 45.5 hr. At 800 ppm, most of the animals were still alive after the 3 months of experimentation. There were no deaths at 400 and 200 ppm. Severe neuromuscular disorders were observed in animals exposed to lethal concentrations.
D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D005260:Female; D006016:Glycolates / Q000633:toxicity*; D007928:Lethal Dose 50; D008099:Liver / Q000473:pathology; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects; D012455:Salamandridae; D012737:Sex Factors
D006016:Glycolates; D008456:2-Methyl-4-chlorophenoxyacetic Acid