Tumour-promoting effect of chilli extract in BALB/c mice.
In 50% of BALB/c mice pretreated with atropine, tongue tumours were induced by fortnightly application of DMN-OAc (2 mg/kg) on the tongue. When DMN-OAc + TPA was used for the initiation-promotion protocol, tumours were observed on the tongue, the site of application, in only 10% of animals. In the same group, stomach tumours were obtained in 63% of mice, denoting that initiation-promotion could be successfully used to induce stomach tumours. Using a protocol of DMN-OAc + chilli as a promoter, we observed induction of stomach tumours. The promoter effect of chilli extract was also seen in the BHC-induced hepato-carcinogenesis system. It thus appears that, in BALB/c mice, chilli acts as a promoter in stomach and liver carcinogenesis.
D000287:Administration, Topical; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002211:Capsaicin / Q000633:toxicity*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D003043:Cocarcinogenesis; D003212:Condiments / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000633:toxicity*; D013274:Stomach Neoplasms / Q000139:chemically induced; D014062:Tongue Neoplasms / Q000139:chemically induced
D010936:Plant Extracts; D001285:Atropine; D002211:Capsaicin