Multisystem degeneration: drugs and square wave jerks.
We studied a 55-year-old woman with macrosquare wave jerks and macrosaccadic oscillations with a vertical component. The oscillations almost completely disappeared after administration of diazepam, clonazepam, thiamylal, or phenobarbital. A disorder of GABAergic tonic inhibitory system from the substantia nigra to superior colliculus probably plays an important the pathogenesis of these abnormal ocular movements. role in the pathogenesis of these abnormal ocular movements.
D002998:Clonazepam / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D009759:Nystagmus, Pathologic / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D010634:Phenobarbital / Q000627:therapeutic use; D013840:Thiamylal / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D013840:Thiamylal; D005680:gamma-Aminobutyric Acid; D002998:Clonazepam; D003975:Diazepam; D010634:Phenobarbital