title: Chromosomal aberrations in lymphocytes of pharmaceutical factory workers.
abstract: Chromosomes were analyzed in peripheral lymphocytes of 31 male workers who were exposed to sulfonamide drugs in a pharmaceutical factory. The number of cells with structural chromosomal aberrations was significantly increased as compared to 15 unexposed individuals (controls). The chromosomal damage observed was mainly gaps and breaks.
mesh_terms: D002869:Chromosome Aberrations; D004345:Drug Industry; D004781:Environmental Exposure; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D013449:Sulfonamides / Q000633:toxicity*
chemical_list: D013449:Sulfonamides