A model of the mechanism of enzyme action in terms of protein conformational relaxation.
A theoretical model of enzymatic reaction is formulated in which the modulation of the reaction coordinates by low-frequency conformational motions of the enzyme molecule causes the lowering of the activation energy barriers until they completely disappear. If the rates of electron transitions in the enzyme-substrate complex exceed the characteristic frequencies of conformational motions then the rate of the elementary enzymatic reaction shows hysteresis dependence on temperature and substrate concentration.
D002384:Catalysis; D004798:Enzymes / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D055585:Physical Phenomena; D010825:Physics; D011487:Protein Conformation; D013816:Thermodynamics
D004798:Enzymes