[Study of the effect of tegalide and bithionol on biological membranes using fluorescent probes].
Fluorescent probes were used to study structural changes in different membranes affected by gamma-radiation, protonophores and radioprotective agents, tegalide and bithionol. The preparations of the defined concentrations decreased the microviscosity of membranes, lowered the peaks and changed the temperature of phase transitions in liposomes from dipalmitoyl lecithin, and induced the output of Ca2+ from mitochondria. The effects depended on the radiation dose, the structure, concentration and lipophilicity of the preparation; protonophores produced a specific effect.
D000818:Animals; D001549:Benzamides; D001735:Bithionol / Q000494:pharmacology*; D003037:Cobalt Radioisotopes; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000528:radiation effects*; D005456:Fluorescent Dyes; D005720:Gamma Rays; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects / Q000528:radiation effects*; D008081:Liposomes / Q000528:radiation effects*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000528:radiation effects; D010636:Phenols / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D001549:Benzamides; D003037:Cobalt Radioisotopes; D005456:Fluorescent Dyes; D008081:Liposomes; D010636:Phenols; D011837:Radiation-Protective Agents; C048082:tegalide; D001735:Bithionol
Issledovanie deĭstviia tegalida i bitionola na biologicheskie membrany s pomoshch'iu fluorestsentnykh zondov.