title: Central versus peripheral effects of bombesin on the release of gastrointestinal hormones in dogs.
abstract: This study compared the effects of bombesin given intracerebroventricularly and intravenously on circulating levels of gastrin, pancreatic polypeptide (PP), and cholecystokinin (CCK-33). Bilateral cannulas were implanted permanently into the lateral cerebral ventricles of five dogs. An intravenous (IV) bolus injection of bombesin (0.25 microgram/kg) significantly elevated circulating levels of gastrin, PP, and CCK-33. Vagotomy inhibited the release of PP that was induced by IV bombesin, but vagotomy did not affect gastrin and CCK-33 responses. Intracerebroventricular injection of bombesin (5.0 micrograms) significantly elevated circulating gastrin levels but did not affect circulating levels of CCK-33 and PP. Vagotomy did not alter gastrin release induced by intracerebroventricular injection of bombesin.
mesh_terms: D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D002766:Cholecystokinin / Q000097:blood*; D004285:Dogs; D005755:Gastrins / Q000097:blood*; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D010191:Pancreatic Polypeptide / Q000097:blood*; D011863:Radioimmunoassay; D014628:Vagotomy
chemical_list: D005755:Gastrins; D010191:Pancreatic Polypeptide; D002766:Cholecystokinin; D001839:Bombesin