Acridinic acid: a new antagonist of amino acid-induced excitations of central neurones.
The actions of acridinic acid (2,3-quinoline dicarboxylic acid), a new derivative of quinolinic acid, as an antagonist of amino acid-induced excitations are described. Acridinate, like kynurenate, in the cerebral cortex reduced the effects of all amino acids equally, but in the spinal cord was significantly less active against quisqualate.
D000596:Amino Acids / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D007736:Kynurenic Acid / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000187:drug effects*; D010848:Picolinic Acids / Q000494:pharmacology; D010875:Pipecolic Acids / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects*
D000596:Amino Acids; D010848:Picolinic Acids; D010875:Pipecolic Acids; D011804:Quinolines; C029262:2,3-piperidinedicarboxylic acid; C049245:acridinic acid; C049246:3-hydroxypicolinic acid; D007736:Kynurenic Acid