Opiate-antagonist reversal of neurological deficits--experimental and clinical studies.
The proximal left M1 and the common trunk of A2 were clipped in 12 adult dogs. Naloxone was injected after placing the clips onto 6 dogs. Neither the systemic blood pressure nor the local cerebral blood flow were influenced by naloxone. In another group of 6 dogs with chronic right hemiplegia, naloxone proved passably effective in improving the hemiplegia. Eight patients with neurological deficits of various etiologies were administered levallorphan. The improvement in motor performance and/or elevation of mental activity was observed more or less in all but 2 of the patients. It was considered that the effect of opiate antagonists is based partially on the facilitation of synaptic transmission exaggerated by the arousal response.
D000328:Adult; D000368:Aged; D000818:Animals; D001783:Blood Flow Velocity; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002642:Chick Embryo; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007977:Levallorphan / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use; D009422:Nervous System Diseases / Q000188:drug therapy* / Q000209:etiology; D014057:Tomography, X-Ray Computed
D009292:Narcotic Antagonists; D007977:Levallorphan; D009270:Naloxone