Pyoderma gangrenosum complicating ulcerative colitis: successful treatment with methylprednisolone pulse therapy and dapsone.
A 36-yr-old patient suffering from chronic ulcerative colitis complicated by severe pyoderma gangrenosum of the leg is presented. Pyoderma gangrenosum rapidly progressed and failed to respond to a combined treatment of bed rest, prednisone, sulfasalazine, povidone-iodine, compresses, and debridement. Pyoderma gangrenosum responded and disappeared with no recurrence during the following months after the combined treatment of methylprednisolone, dapsone, and zinc sulfate.
D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications*; D003622:Dapsone / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007868:Leg Dermatoses / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D011711:Pyoderma / Q000150:complications / Q000188:drug therapy*; D013431:Sulfates / Q000627:therapeutic use; D015032:Zinc / Q000627:therapeutic use; D019287:Zinc Sulfate
D013431:Sulfates; D019287:Zinc Sulfate; D003622:Dapsone; D015032:Zinc; D008775:Methylprednisolone