Scanning electron microscopic studies of the membranous labyrinth after transtympanic infusion of local anesthetics (lidocain).
Scanning electron microscopic observation of the transtympanic infusion of 10% xylocain revealed twisting and disorders of outer hairs especially from the 2nd and 3rd rows of the basal to the 2nd turn of the organ of Corti, and adhesion and fusion of the sensory hairs of the crista ampullaris and otolith organ 1 and 4 days after injection. Four percent xylocain however demonstrated very minor alteration of the sensory hairs and no missing sensory hairs were detected from any cases. The authors hypothesized from electron microscopic observation that adhesion and fusion of vestibular sensory hairs or twisting and disorders of the sensory hairs of the organ of Corti might act to intercept harmful circulation of exclusion of abnormal excitement of hair cells and the innovation of electrical discharge of sensory hairs due not only to the pharmacological effects of xylocain but also to osmotic pressure.
D000818:Animals; D002923:Cilia / Q000187:drug effects / Q000648:ultrastructure; D010856:Columbidae; D007758:Ear, Inner / Q000187:drug effects* / Q000648:ultrastructure; D006168:Guinea Pigs; D008012:Lidocaine / Q000009:adverse effects / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D009759:Nystagmus, Pathologic / Q000209:etiology; D009925:Organ of Corti / Q000187:drug effects / Q000648:ultrastructure; D010037:Otolithic Membrane / Q000187:drug effects / Q000648:ultrastructure
D008012:Lidocaine