Surgical revascularization of acute (1 hour) coronary occlusion: blood versus crystalloid cardioplegia.
This study compares blood versus crystalloid cardioplegia in restoring contractile function, and high-energy phosphate and tissue water content in a myocardial segment after 1 hour of coronary artery occlusion. Anesthetized dogs underwent instrumentation with the chest open to measure left ventricular and aortic pressures, and systolic shortening in the myocardium perfused by the left anterior descending coronary artery (LAD) was measured with ultrasonic crystals. In 21 dogs, the LAD was occluded for an hour, thereby replacing systolic shortening with passive lengthening averaging -28.7 +/- 6.2% of control shortening in both groups. The dogs were then placed on total bypass, and arrest was achieved with multidose crystalloid (N = 10) or blood cardioplegia (N = 11). The ligatures were released just prior to the second infusion of cardioplegic solution. Postischemic subendocardial levels of adenosine triphosphate were comparably depleted with crystalloid and blood cardioplegia (55.2% and 44.0%, respectively, of control). Subendocardial increases in water content were similar for crystalloid (3.62%) and blood (3.16%) cardioplegia. Recovery of segmental shortening was significantly greater with blood than crystalloid cardioplegia (31.5 +/- 8.2% versus 4.9 +/- 6.6% of control, respectively). We conclude that the composition and the delivery of blood cardioplegia used in this study restore greater postischemic function than crystalloid cardioplegia in acute evolving myocardial infarction.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001834:Body Water / Q000378:metabolism; D003326:Coronary Circulation; D003327:Coronary Disease / Q000473:pathology; D004285:Dogs; D005069:Evaluation Studies as Topic; D006324:Heart Arrest, Induced / Q000379:methods*; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D009336:Necrosis; D010725:Phosphocreatine / Q000378:metabolism; D011184:Postoperative Period; D011188:Potassium; D017680:Potassium Compounds
D017680:Potassium Compounds; C018369:potassium cardioplegic solution; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D011188:Potassium