Influence of long-term low direct current on rat ischiadic nerves.
The effects of a low direct current on peripheral nerves and electrodes on the ischiadic nerve were investigated, and a constant direct current was applied for various time periods. Afterwards clinicophysiological tests and histological evaluations were performed. The muscles of 55 rats could be stimulated by external stimulation during the follow-up examinations, but 90% of all animals showed microscopically visible nerve tissue alterations which might have been caused by mechanical rather than electrolytic factors.
D000818:Animals; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D006614:Hindlimb / Q000294:innervation; D008297:Male; D008839:Microelectrodes; D009068:Movement; D009132:Muscles / Q000294:innervation / Q000502:physiology; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000166:cytology / Q000502:physiology*; D051381:Rats; D011930:Reaction Time / Q000502:physiology; D013997:Time Factors