title: Two new quassinoids from Simaba multiflora fruits.
abstract: Two new quassinoids, 13, 18-dehydro-6 alpha-senecioyloxychaparrin (4) and 12-dehydro-6 alpha-senecioyloxychaparrin (5), have been isolated from Simaba multiflora fruits. Their structures were deduced from spectral data. 1H-13C 2-D chemical-shift correlation nmr was applied to the structural elucidation of the antileukemic quassinoid 4.
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D005616:French Guiana; D005900:Glaucarubin / Q000031:analogs & derivatives / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D007942:Leukemia, Experimental / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010616:Phenanthrenes / Q000302:isolation & purification*; D010946:Plants, Medicinal / Q000032:analysis*; D036702:Quassins
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010616:Phenanthrenes; D036702:Quassins; C049072:13,18-dehydro-6alpha-senecioyloxychaparrin; C049071:12-dehydro-6alpha-senecioyloxychaparrin; D005900:Glaucarubin