A kinetic study on chlorpromazine disposition and hypothermic response in rats.
Pharmacokinetic relationships were developed to characterize a multi-exponential drug disposition and pharmacologic response time courses. The derived expressions were applied to serum and cerebral concentrations and the hypothermic response data, which were obtained after rapid intravenous administration of chlorpromazine hydrochloride to rats. The results of this study indicate that the magnitude of the pharmacologic effects of chlorpromazine such as decrease in metabolic heat production and increase in tail blood flow, at a given time, are logarithmic logistic functions of the cerebral chlorpromazine concentration at that time.
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002746:Chlorpromazine / Q000378:metabolism* / Q000494:pharmacology; D007036:Hypothermia, Induced; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D013623:Tail / Q000098:blood supply; D013997:Time Factors
D002746:Chlorpromazine