Possible role of sulfhydryls in mucosal protection induced by aluminum hydroxide.
The involvement of sulfhydryl-containing compounds was investigated in the cytoprotective effect of certain antacids against ethanol-induced gastric mucosal damage in the rat. Not only the protective effect of a sulfhydryl containing compound, N-acetylcysteine, was abolished after pretreatment with N-ethylmaleimide, but also the adaptive cytoprotection induced by 20% ethanol. Pretreatment of the animals with the cyclooxygenase inhibitor indomethacin or with the thiol reagent N-ethylmaleimide significantly diminished the cytoprotection evoked by aluminum hydroxide. However, the protective effect of aluminium hydroxide could only be totally abolished by pretreatment with the combination of indomethacin and N-ethylmaleimide. The present results suggest the additional role of sulfhydryl-containing compounds localized in the gastric mucosa in the cytoprotection induced by a mild irritant or by aluminium hydroxide and aluminium hydroxide-containing antacids as well.
D000111:Acetylcysteine / Q000494:pharmacology; D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000818:Animals; D000431:Ethanol / Q000633:toxicity; D005033:Ethylmaleimide / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000494:pharmacology*
D013438:Sulfhydryl Compounds; D000431:Ethanol; D000536:Aluminum Hydroxide; D005033:Ethylmaleimide; D000111:Acetylcysteine; D007213:Indomethacin