Analgesic actions of 3-substituted 6-tert-butyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines.
The synthesis of four 3-substituted 6-tert-butyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines is described. Derivatives with N-Me or N-phenethyl substituents do not differ significantly in their antinociceptive properties from compounds bearing 6-H or 6-Me; however, they are less active than 6-Ph analogues.
D000698:Analgesia; D000818:Animals; D001575:Benzomorphans / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D009019:Morphinans / Q000138:chemical synthesis; D013329:Structure-Activity Relationship
D001575:Benzomorphans; D009019:Morphinans