Displacement effect of ceftriaxone on bilirubin bound to human serum albumin.
The effects of ceftriaxone, a 'third-generation' cephalosporin, on bilirubin-serum albumin complexes were investigated. This study was performed on human adult samples at various bilirubin-albumin ratios. Ceftriaxone caused a decrease of unconjugated bilirubin and simultaneously an increase of erythrocyte-bound bilirubin. These variations were proportionally more important for low concentrations of antibiotic, including therapeutic values. It was concluded that ceftriaxone competes with bilirubin and displaces it from albumin-binding sites.
D001663:Bilirubin / Q000097:blood*; D001667:Binding, Competitive; D002443:Ceftriaxone / Q000097:blood*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*
D012709:Serum Albumin; D002443:Ceftriaxone; D001663:Bilirubin