Naltrexone inhibits the persistent spasmodic dyskinesia induced by chronic intraperitoneal administration of iminodipropionitrile (IDPN).
The effects of naltrexone on the persistent movement disorder induced in mice by the neurotoxic substance IDPN were examined. Naltrexone (2-4 mg/kg, IP) significantly reduced the hyperactivity and the stereotypic behaviors induced by IDPN. Fifteen minutes after the injection of naltrexone, the dyskinetic neck movements were almost completely inhibited at the higher dose. Thus, blockade of opiate receptors can significantly affect drug-induced persistent dyskinesia.
D000818:Animals; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000503:physiopathology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009271:Naltrexone / Q000494:pharmacology / Q000627:therapeutic use*; D009570:Nitriles; D013997:Time Factors
D009570:Nitriles; C008110:3,3'-iminodipropionitrile; D009271:Naltrexone