[Experimental tyrosine keratopathy in rabbits].
Tyrosine was given to White New Zealand and Chinchilla bastard rabbits. The corneal epithelium showed pinpoint lesions and a pseudokeratitis dendritica from the fourth day on. In spite of continued tyrosine dosage these lesions disappeared clinically within 6 days. Scanning electron microscopy revealed necrosis of isolated epithelial cells even after the twentieth day of tyrosine dosage. Specular microscopy sporadically revealed glittering pre-endothelial structures. It was found by light microscopy that there was a tendency to focal proliferation of corneal epithelial cells and a vacuolization in the basal epithelial cell layers. Endothelial defects may be responsible for circumscribed edema of the corneal stroma.
D000284:Administration, Oral; D000818:Animals; D003315:Cornea / Q000187:drug effects; D003318:Corneal Opacity / Q000139:chemically induced; D004727:Endothelium / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects; D007635:Keratitis, Dendritic / Q000139:chemically induced*; D008297:Male; D008855:Microscopy, Electron, Scanning; D009336:Necrosis; D011817:Rabbits; D014443:Tyrosine / Q000633:toxicity*
D014443:Tyrosine
Experimentelle Tyrosinkeratopathie bei Kaninchen.