Increased norepinephrine synthesis in the cerebral hemispheres of rats following subarachnoid hemorrhage.
Norepinephrine (NE) was assayed in rat brains 72 h after the creation of an experimental subarachnoid hemorrhage (SAH). NE in the cerebral hemispheres was found to increase by 64% when compared to controls. NE in the brainstem and cerebellum was unchanged. The kinetics of hemispheric NE metabolism were then studied in control and SAH rats. SAH caused a 3-fold increase in NE synthesis and a 44% reduction in turnover time when compared to controls. These results may reflect increased activity of central noradrenergic neuronal pathways in SAH.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013345:Subarachnoid Hemorrhage / Q000378:metabolism*
D009638:Norepinephrine