Qualitative differences in effects of opioids in man: preliminary evidence for multiple mechanisms of analgesic action.
The analgesic effects of meperidine, anileridine, codeine and codeine + acetominophen on surgical and non-surgical pain in 101 patients were assessed using the McGill Pain Questionnaire. The quality of analgesia was determined by analyzing the changes in the pain descriptors chosen 1 hour after medication. Meperidine and anileridine differentially reduced pain qualities rated as "bright-phasic" by a student sample. Codeine and codeine + acetominophen produced similar patterns of analgesia that were homogeneous across "bright-phasic" and "dull-tonic" types of pain. The data suggest the possibility that opioids may differ in the quality of analgesia produced either as dose increases or different opioid receptor types are recruited.
D000082:Acetaminophen / Q000627:therapeutic use; D003061:Codeine / Q000627:therapeutic use; D006801:Humans; D007540:Isonipecotic Acids / Q000627:therapeutic use; D008614:Meperidine / Q000627:therapeutic use; D009294:Narcotics / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*
D007540:Isonipecotic Acids; D009294:Narcotics; D000082:Acetaminophen; C100232:anileridine; D008614:Meperidine; D003061:Codeine