Topical flucytosine therapy for chronic recurrent Candida tropicalis infections.
Forty-one women with a culture-proven diagnosis of Candida tropicalis were treated with miconazole or clotrimazole cream topically or ketoconazole orally. In 15 patients the infection recurred or remained uncured. Five-fluorocytosine was compounded into a topical vaginal cream and applied nightly for seven nights. In 14 of the 15 patients the infection disappeared. One patient remains uncured.
D002177:Candidiasis / Q000188:drug therapy*; D002908:Chronic Disease; D005260:Female; D005437:Flucytosine / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D012008:Recurrence; D014622:Vaginal Creams, Foams, and Jellies; D014623:Vaginal Diseases / Q000188:drug therapy*
D014622:Vaginal Creams, Foams, and Jellies; D005437:Flucytosine