High 1,25-dihydroxyvitamin D and low 25-hydroxyvitamin D concentrations in plasma in patients receiving antiepileptic drugs.
Plasma 25-hydroxyvitamin D (25-OH D), 1,25-dihydroxyvitamin D (1,25-(OH)2 D) and parathyroid hormone (PTH) concentrations were determined in 30 outpatients receiving various antiepileptic drugs (AED). None of the patients exhibited high plasma PTH levels. The plasma 1,25-(OH)2 D levels were normal or high, although in a third of the patients the 25-OH D levels were reduced. There was a correlation between the 25-OH D and serum calcium levels. These findings suggest that the low plasma concentrations of 25-OH D, not 1,25-(OH)2 D, might play an important part in the occurrence of AED-induced disturbances of bone metabolism.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D000927:Anticonvulsants / Q000008:administration & dosage*; D002118:Calcium / Q000097:blood; D004100:Dihydroxycholecalciferols / Q000097:blood* / Q000378:metabolism; D004338:Drug Combinations; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood
D000927:Anticonvulsants; D004100:Dihydroxycholecalciferols; D004338:Drug Combinations; D010281:Parathyroid Hormone; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium