Theophylline pharmacokinetics after intravenous infusion with ethylenediamine or sodium glycinate.
Six healthy volunteers received two theophylline preparations by short intravenous infusion, at weekly intervals in a randomized cross-over design. The solubilizer was ethylenediamine or sodium glycinate. Plasma concentrations of theophylline and ethylenediamine were measured by h.p.l.c. for up to 24 h after dosing. The pharmacokinetics of theophylline did not show any significant intra-subject variation associated with the solubilizing agent used.
D000328:Adult; D004339:Drug Compounding; D005029:Ethylenediamines / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D005998:Glycine / Q000378:metabolism*; D006801:Humans; D007262:Infusions, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010592:Pharmaceutic Aids / Q000378:metabolism / Q000494:pharmacology*; D012995:Solubility; D013806:Theophylline / Q000008:administration & dosage / Q000378:metabolism*
D005029:Ethylenediamines; D010592:Pharmaceutic Aids; D013806:Theophylline; D005998:Glycine