The influence of cholecystokinin octapeptide and angiotensin II on in vitro duodenal motility in hibernating and aroused 13-lined ground squirrels.
Because cholecystokinin octapeptide and angiotensin II are directly involved in intestinal food and water absorption, the effect of these two compounds on intestinal motor responses of hibernating and alert 13-lined ground squirrels was investigated. Both cholecystokinin octapeptide and angiotensin II caused a greater increase in the composite motility of intestinal segments of normothermic in contrast to hypothermic hibernating ground squirrels. Additionally, cholecystokinin caused an increase in the contraction frequency of the intestine from normothermic as compared to hypothermic squirrels. This differential response may provide an adaptive advantage by decreasing food and water consumption; depressing motility and inhibiting digestive enzyme release; reducing the release of bile which also may have an irritant effect on the intestinal mucosa under prolonged exposure. As a result, the GI tract is devoid of food and digestive enzyme irritants during torporous periods.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001143:Arousal; D004386:Duodenum / Q000187:drug effects / Q000502:physiology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006605:Hibernation; D006801:Humans; D007700:Kinetics; D012589:Sciuridae / Q000502:physiology*; D012844:Sincalide / Q000494:pharmacology*
D000804:Angiotensin II; D012844:Sincalide