Metabolism of 3H-proline in riboflavin deficiency.
Riboflavin deficiency and food restriction were associated with greater solubility and lesser total and insoluble collagen concentration in rat skin. Studies using 3H-proline suggest that the lower collagen concentration under these conditions could be due to a decrease in synthesis as well as slow maturation of collagen. The mechanisms underlying defective cross-link formation appear to be different in food-restricted and riboflavin-deficient rats. Half-life of soluble collagen was not affected in riboflavin deficiency, but it was slightly shorter in food-restricted weight-matched animals.
D000818:Animals; D003094:Collagen / Q000378:metabolism*; D006909:Hydroxyproline / Q000652:urine; D008297:Male; D011392:Proline; D051381:Rats; D011919:Rats, Inbred Strains; D012257:Riboflavin Deficiency / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D012995:Solubility
D003094:Collagen; D011392:Proline; D006909:Hydroxyproline