Delayed reaction of Bence Jones proteins to sulfosalicylic acid.
The present investigation was undertaken in order to elucidate the delayed reaction of Bence Jones proteins to sulfosalicylic acid. The author observed this interesting phenomenon in 2 of 32 untreated patients with multiple myeloma who excreted Bence Jones proteins. Their urine samples contained a large amount of Bence Jones proteins with alpha 2 mobility on electrophoresis, which is rarely encountered in urinary Bence Jones proteins. The delayed reaction may be linked, in part at least, to the chemical properties of Bence Jones proteins responsible for alpha 2 mobility.
D000368:Aged; D001536:Bence Jones Protein / Q000652:urine*; D001557:Benzenesulfonates; D005188:False Negative Reactions; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000652:urine; D012459:Salicylates; D013997:Time Factors
D001557:Benzenesulfonates; D012459:Salicylates; D001536:Bence Jones Protein; C003366:sulfosalicylic acid