PD 116,152, a novel phenazine antitumor antibiotic. Discovery, fermentation, culture characterization and biological activity.
A novel phenazine antitumor antibiotic is described, produced by Streptomyces lomondensis subsp. galanosa NRRL 15738. The antibiotic is selectively active versus the bacterium Streptococcus pneumoniae (MIC less than 0.46 microgram/ml); the antitumor activity versus murine P388 leukemia is T/C 149.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D010619:Phenazines / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D010619:Phenazines; C048268:PD 116152