title: [Electrophysiologic analysis of the selectivity of action of anticholinesterase preparations in hereditary ataxias].
abstract: The selectivity of action of anticholinesterase drugs (ACE drugs) in hereditary ataxias was studied using methods of registration of short latent stem-induced potentials to acoustic stimulation and assessment of the parameters of visual motor coordination. The findings obtained show the involvement in the pathological process of the brain stem in hereditary ataxias and the heterogeneity of action of ACE drugs. Thus, amiridine acted predominantly on efferent while galanthamine on afferent conduction of impulses.
mesh_terms: D000293:Adolescent; D000328:Adult; D000634:Aminoquinolines; D001933:Brain Stem; D002524:Cerebellar Ataxia / Q000188:drug therapy* / Q000235:genetics; D002607:Charcot-Marie-Tooth Disease / Q000188:drug therapy; D002648:Child; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D005072:Evoked Potentials, Auditory; D005621:Friedreich Ataxia / Q000188:drug therapy; D005702:Galantamine / Q000627:therapeutic use*; D006801:Humans; D011597:Psychomotor Performance; D013577:Syndrome
chemical_list: D000634:Aminoquinolines; D002800:Cholinesterase Inhibitors; D005702:Galantamine; C049860:amiridine
vernacular_title: Elektrofiziologicheskiĭ analiz izbiratel'nosti deĭstviia antikholésteraznykh preparatov pri geredoataksiiakh.