De novo sn-glycerol-3-phosphorylcholine synthetase activity in lung and muscle and its subcellular location.
The activity of glycerophosphorylcholine synthetase, a newly discovered enzyme involved in the synthesis of acyl-specific phosphatidylcholines, is reported in rat lung and muscle. Its subcellular location appears to be mitochondrial. The implication of these findings in the synthesis of lung surfactant and the pathology of muscular dystrophy are discussed.
D000818:Animals; D008168:Lung / Q000201:enzymology* / Q000648:ultrastructure; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D009132:Muscles / Q000201:enzymology* / Q000648:ultrastructure; D009137:Muscular Dystrophy, Animal / Q000473:pathology; D019884:Nitrogenous Group Transferases; D010713:Phosphatidylcholines / Q000096:biosynthesis; D011663:Pulmonary Surfactants / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D014166:Transferases / Q000378:metabolism*
D010713:Phosphatidylcholines; D011663:Pulmonary Surfactants; D014166:Transferases; D019884:Nitrogenous Group Transferases; C050703:sn-glycerol-3-phosphorylcholine synthetase