Further evidence for the effect of pinacolyl dimethylphosphinate on soman storage in muscle tissue.
Diaphragms isolated from rats 60 or 120 min after the intravenous injection of 6 X LD50 soman were incubated with electric eel acetylcholinesterase. As calculated from the enzyme inhibition, detectable amounts of P(-)-soman (1,2-dimethylpropyl methylphosphonofluoridate) were released from the diaphragm into the medium even 120 min post-injection. This release was reduced by additional pretreatment of the rats with pinacolyl dimethylphosphinate, providing further evidence that this compound prevents the storage of soman in diaphragm tissue.
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000378:metabolism; D003964:Diaphragm / Q000378:metabolism; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012999:Soman / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; C048957:pinacolyl dimethylphosphinate; D012999:Soman