Unusual trihydroxy bile acids in the urine of healthy humans.
The urinary bile acids of 20 adults (aged between 20 and 40 yr), 17 neonates (below 1 week old) and 15 aged men (older than 80 yr old) who were all healthy, were analyzed by gas-liquid chromatography and gas-liquid chromatography-mass spectrometry. Frequently, three unusual trihydroxy bile acids, namely hyocholic acid, ursocholic acid and omega-muricholic acid were detected as minor components. Our data further suggest that the metabolism of unusual trihydroxy bile acids in the healthy humans is related to age.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001647:Bile Acids and Salts / Q000652:urine*; D002793:Cholic Acids / Q000652:urine; D002849:Chromatography, Gas; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007231:Infant, Newborn; D008297:Male
D001647:Bile Acids and Salts; D002793:Cholic Acids; C004821:muricholic acid; C030712:ursocholic acid