title: The influence of phosphodiesterase inhibitors on ERG and optic nerve response of the cat.
abstract: Reversible changes in electroretinograms (ERG) and optic nerve responses (ONR), induced by various concentrations of four different types of phosphodiesterase (PDE)-inhibitors, were recorded from arterially perfused, isolated cat eyes. In the dark-adapted eye, the implicit time of the PIII-component of the ERG, isolated by temporary hypoxia, showed a dose-dependent increase after the injection of PDE-inhibitors into the ophthalmociliary artery. The PIII-amplitude increased in response to small doses of PDE-inhibitors, whereas higher doses led to an amplitude decrease. Rod b-wave amplitude and implicit time showed similar alterations. An amplitude increase could not be observed in the rod ONR. In the light-adapted eye, 440 nm and 555 nm cones were functionally separated by means of chromatic adaptation. Their ERG and ONR implicit times were prolonged under PDE-inhibition. The amplitude behaviour of both types of cones showed a different concentration dependency. Certain concentrations of PDE-inhibitors depressed the short-wavelength sensitive cone, while, at the same time, sensitizing the long-wavelength sensitive cone. The amplitude increase of the L-cone b-wave was accompanied by a response increase of tonic ganglion cells in the ONR.
mesh_terms: D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002415:Cats; D003623:Dark Adaptation; D004596:Electroretinography; D005260:Female; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D009900:Optic Nerve / Q000187:drug effects*; D010208:Papaverine / Q000494:pharmacology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010786:Photoreceptor Cells / Q000187:drug effects; D012160:Retina / Q000187:drug effects*; D013806:Theophylline / Q000494:pharmacology
chemical_list: D007093:Imidazoles; D010726:Phosphodiesterase Inhibitors; D002110:Caffeine; D013806:Theophylline; D010208:Papaverine; C029758:sulmazole