Kindling-like phenomenon in the isolated ileum of the guinea-pig.
Repeated bursts of low voltage electrical stimulation of the isolated ileum of the guinea-pig gradually leads to the development and progressive intensification of the tissue basal activity, culminating in spontaneous, sudden strong contractions of the preparation, which persist for several hours after the stimulation has been discontinued. The magnitude of these alterations are determined by the parameters of the stimulation, mainly by the number of electrical stimulations, the frequency of stimulation, and the interstimulus interval. Maximal alterations are obtained with periods of stimulation of 20 Hz for 10 sec, pulses of 3.0 msec, repeated every 20 min for 15 times. Phenytoin, flunitrazepam, diazepam, phenobarbital and carbamazepine effectively inhibited the fully developed phenomenon in the tissues. The effect described in this report may be related to kindling in the brain.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D004558:Electric Stimulation / Q000009:adverse effects; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000503:physiopathology*; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000503:physiopathology*
D000927:Anticonvulsants