[Structure of teichoic acid of a poly(glycerophosphate) nature from Streptomyces levoris K-3053 and its biological properties].
The wall teichoic acid from S. levoris was studied. It is a poly(glycerophosphate)polymer consisting of 15-20 nonsubstituted glycerophosphate units coupled by the phosphodiether bonds according to the 1, 3 type. It was shown that the acid had antitumor activity and high cardiotoxicity evident from a clear-cut negative ionotropic effect on the cardiac papillar muscle in dogs.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002473:Cell Wall / Q000378:metabolism; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005994:Glycerophosphates / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D066298:In Vitro Techniques; D051379:Mice; D010210:Papillary Muscles / Q000187:drug effects; D012510:Sarcoma 180 / Q000188:drug therapy; D013302:Streptomyces / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013682:Teichoic Acids / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity
D000970:Antineoplastic Agents; D005994:Glycerophosphates; D013682:Teichoic Acids; C008964:polyglycerolphosphate
Struktura teĭkhoevoĭ kisloty poli(glitserofosfatnoĭ) prirody Streptomyces levoris K-3053 i nekotorye ee biologicheskie svoĭstva.