title: Non-linear fitting program for biological data.
abstract: A simple microcomputer program written in Microsoft Basic estimates pharmacokinetic parameters using the coordinate search technique to minimize the sum of squared errors. The program developed for portable computers combines a plot of data and curve fitting so as to find rapidly the initial parameters with the subsequent optimization of the parameter estimate.
mesh_terms: D003201:Computers; D006801:Humans; D007700:Kinetics; D008838:Microcomputers; D010197:Pancuronium / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012984:Software
chemical_list: D004364:Pharmaceutical Preparations; D010197:Pancuronium