title: Behavioral changes in preweaning and adult rats exposed prenatally to low ionizing radiation.
abstract: Seven behavioral tests were used to evaluate the postnatal behavior of rats after exposure on gestational Day 15 to 0, 25, 50, 75, or 125 r, whole body irradiation of the pregnant rat. Three tests were administered in the first 2 postnatal weeks (righting reflex, negative geotaxis, and reflex suspension); three tests were administered on postnatal Day 21 (modified open field, spatial maze, and continuous corridor). As adults, the rats were retested with the same tests as at 21 days and also in the running wheel. Dose-response decreases in body weight were greater in the younger rats. Some behavioral tests were not altered by irradiation, while others showed clear dose-response relationships, starting as low as 25 r. The early changes were characterized by light body weight, delays in behavioral development and hypoactivity, followed by recovery of some parameters with maturation. Eventually hyperactivity developed in adult rats after gestational irradiation. However, it cannot be concluded that either morphological or behavioral tests are more sensitive than neonatal body weight change for detection of damage from gestational irradiation.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000528:radiation effects*; D001835:Body Weight / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D009043:Motor Activity / Q000528:radiation effects*; D011247:Pregnancy; D011839:Radiation, Ionizing; D051381:Rats; D011919:Rats, Inbred Strains; D012021:Reflex, Abnormal / Q000209:etiology*