Susceptibility of rats to infection with Toxocara pteropodis.
Infective eggs of Toxocara pteropodis were administered to Wistar rats via oral and parenteral routes. Third-stage larvae were recovered from the livers of suckling young 8 days after oral infection, and from livers and lungs after intraperitoneal or subcutaneous inoculation of eggs. These larvae were short-lived as none were found in suckling mice killed 2 weeks post-infection. Larvae were not recovered from tissues of rats aged 22 days or more when inoculated orally, indicating that refractoriness to infection develops rapidly with growth. Small numbers of larvae were recovered from the lungs of older rats 4 days after subcutaneous but not after oral inoculation. Adult male Buffalo and Fisher rats were also totally resistant to oral infection. Hence, rats differ from mice in their susceptibility to T. pteropodis.
D000375:Aging; D000818:Animals; D000833:Animals, Suckling; D001196:Ascariasis / Q000469:parasitology*; D004198:Disease Susceptibility; D007814:Larva; D008099:Liver / Q000469:parasitology; D008168:Lung / Q000469:parasitology; D008297:Male; D051381:Rats; D011915:Rats, Inbred BUF; D011919:Rats, Inbred Strains; D014119:Toxocara / Q000502:physiology*; D014120:Toxocariasis / Q000469:parasitology*