Blunted response of serum aldosterone to metoclopramide in the male elderly.
Serum aldosterone values were determined in 6 elderly (70-82 years) and in 6 adult (31-43 years) male subjects after the intravenous administration of 10 mg of metoclopramide. A significant difference in the metoclopramide-induced serum aldosterone rise was found between the two groups, it being blunted in the older subjects (serum aldosterone peak values: 15.8 +/- 3.6 ng/dl and 38.7 +/- 4.9 ng/dl in elderly and in adult subjects, respectively). The existence of an impaired aldosterone secretion in response to dopaminergic blockade in the elderly is postulated.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000450:Aldosterone / Q000097:blood*; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*
D000450:Aldosterone; D008787:Metoclopramide