title: Differences in the long chain (sphingoid) base composition of sphingomyelin from rats bearing Morris hepatoma 7777.
abstract: The long chain bases of sphingomyelin from Morris hepatoma 7777 and host and control livers were analyzed by capillary gas liquid chromatography. Sphingosine (18:1) was the major long chain base of control livers (66.5%) and hepatomas (65.6%), but hepatomas also had a high percentage (9.3 vs 4.4) of the 16:1 homolog. Host liver had the most unusual long chain base composition, with ca. equal 16:1 (24.4%) and 18:1 (21.4%) and high amounts of 20-carbon bases (9.2% 20:0 and 15.3% 20:1). These differences may be related to the aberrant fatty acid metabolism known to occur in tumor-bearing animals. Such large perturbations in the long chain base composition of hepatic sphingomyelin are unprecedented and could have a major impact on the properties of host membranes.
mesh_terms: D000818:Animals; D002849:Chromatography, Gas; D005260:Female; D008099:Liver / Q000032:analysis*; D008114:Liver Neoplasms, Experimental / Q000032:analysis*; D051381:Rats; D011915:Rats, Inbred BUF; D013109:Sphingomyelins / Q000302:isolation & purification*; D013110:Sphingosine / Q000032:analysis*
chemical_list: D013109:Sphingomyelins; D013110:Sphingosine