title: Hepatic disease in the Spanish toxic oil syndrome. A thirty months follow-up study.
abstract: Clinical and biological evidence of liver disease was found in 99 out of 242 (40%) patients hospitalized with acute manifestations of the Spanish toxic oil syndrome. No patient was alcoholic. According to the severity of liver involvement, patients were classified in 3 groups and followed up for at least 30 months. Group I included 65 patients with a transient increase of serum aminotransferase activity as the only evidence of liver disease. This abnormality disappeared within 2 months in all these patients. Group II included 18 patients with raised aminotransferases and alkaline phosphatase. At the end of follow-up, liver tests remained slightly abnormal in 4 patients of this group (22%) and a liver biopsy revealed minor changes in 3 of them. Group III included 16 patients with raised aminotransferases, alkaline phosphatase and bilirubin. Thirty months after the acute episode, liver function tests remained abnormal in 8 patients (50%); a liver biopsy, performed in 5 cases, showed changes suggesting chronic biliary disease in 2, and fibrosteatosis, chronic hepatitis and minimal changes in each of the remaining 3. Pulmonary, cutaneous, vascular, neuromuscular and other extra-hepatic disturbances were noted in a large number of patients but no relationship was observed between the degree of hepatic disfunction and the presence and severity of systemic manifestations of the toxic oil syndrome.
mesh_terms: D000328:Adult; D001706:Biopsy; D001937:Brassica; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005229:Fatty Acids, Monounsaturated; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D009821:Oils / Q000506:poisoning*; D010938:Plant Oils; D000074262:Rapeseed Oil; D013030:Spain; D013577:Syndrome; D013997:Time Factors
chemical_list: D005229:Fatty Acids, Monounsaturated; D009821:Oils; D010938:Plant Oils; D000074262:Rapeseed Oil