title: Changes in endolymph chloride concentration following furosemide injection.
abstract: Endocochlear potential (EP) and chloride concentration in endolymph were monitored with microelectrodes in the basal turn of the cochlea of the chinchilla. After intravenous injection of furosemide (25-100 mg/kg), the EP dropped precipitously and rapidly reached its minimum value, however, the chloride activity in endolymph decreased more gradually. Possible mechanisms for this phenomenon include a reduced electrostatic attraction of chloride ions to the scala media due to a decreased EP and a reduction of passive influx of chloride into endolymph, resulting from a reduction of active inward potassium transport by furosemide.
mesh_terms: D000818:Animals; D002682:Chinchilla; D002712:Chlorides / Q000032:analysis*; D003051:Cochlea / Q000187:drug effects*; D004594:Electrophysiology; D004710:Endolymph / Q000032:analysis*; D005665:Furosemide / Q000494:pharmacology*; D007761:Labyrinthine Fluids / Q000032:analysis*
chemical_list: D002712:Chlorides; D005665:Furosemide