LDH isoenzymes in CSF in the diagnosis of neonatal brain damage.
Lactate dehydrogenase isoenzymes in cerebrospinal fluid were measured during the first 24 h of life in 25 asphyctic neonates. The infants were subjected to clinical and developmental examinations for a mean follow-up period of 15.2 months. The mean values for cerebrospinal LDH2(MH3) and LDH3(M2H2) isoenzymes were significantly higher in asphyctic infants who died from hypoxic-ischemic encephalopathy or who survived but suffered neurologic sequelae, than they were in those asphyctic infants who survived and were normal in the follow-up studies. Therefore, the authors conclude that the lactate dehydrogenase isoenzyme pattern in cerebrospinal fluid may be of value when assessing anoxic brain damage.
D001238:Asphyxia Neonatorum / Q000134:cerebrospinal fluid / Q000150:complications*; D001925:Brain Damage, Chronic / Q000134:cerebrospinal fluid* / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid*; D011379:Prognosis
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase