[Comparative effectiveness of metronidazole, hyperglycemia and hyperthermia in irradiation of Ehrlich carcinoma with fast neutrons].
A study was made of a possibility of the modification of the effects of fast neutrons (with the mean energy of about 6 MeV.) by local hyperthermia (HT), short-term induced hyperglycemia (STIH) and metronidazole (MZ). The study was conducted in vivo on intramuscularly transplantable ascitic mouse Ehrlich's carcinoma. The dose-effect relationship built up in different time after the day of irradiation, was considered in parallel with the time course of tumor growth; regression curves were obtained using computer. Using the value of 50% tumor growth inhibition and the ratio of areas under the model dose-effect curves as criteria of a degree of modification the authors have come to a conclusion that HT possesses the most noticeable intensifying effect.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D005214:Fast Neutrons; D005947:Glucose / Q000494:pharmacology*; D006979:Hyperthermia, Induced; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D051379:Mice; D011836:Radiation Tolerance; D012062:Relative Biological Effectiveness
D008795:Metronidazole; D005947:Glucose
Sravnitel'naia éffektivnost' metronidazola, giperglikemii i gipertermii pri obluchenii kartsinomy Erlikha bystrymi neĭtronami.