Serum lipid peroxide levels of albino rats administered naphthalene.
When naphthalene was administered at a daily dose of 1 g/kg body weight to Wistar strain rats, their serum lipid peroxide levels were increased on the 4th day after the first administration and reached a maximum on the 7th day. This seems to be due to lipid peroxidation in the liver, in which lipid peroxide levels were increased in a similar pattern as those in the serum. The content of reduced glutathione in lenses of naphthalene-administered rats decreased on the 4th day. These results suggest that in naphthalene-induced cataract in albino rats increased lipid peroxides in the bloodstream may play a role in cataractogenesis.
D000818:Animals; D002386:Cataract / Q000139:chemically induced; D005978:Glutathione / Q000378:metabolism; D007908:Lens, Crystalline / Q000378:metabolism; D008054:Lipid Peroxides / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D009281:Naphthalenes / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D008054:Lipid Peroxides; D009281:Naphthalenes; C031721:naphthalene; D005978:Glutathione