The role of adipose and hepatic tissues in the lipogenesis of the dog.
In order to determine the main organ of fatty acid synthesis de novo in the dog, glucose-C incorporation into fatty acids and glucose-1-C oxidation to CO2 were measured by means of glucose-U-14C and glucose-1-14C in samples of adipose and hepatic tissues of 16 animals. For comparison of the two organs the data were referred to the respective DNA content. The rate of glucose-C incorporation into fatty acids of adipose tissue exceeded that of hepatic tissue about 1000-fold. Therefore, the adipose tissue is to be considered the almost exclusive organ of lipogenesis in the adult dog. Glucose-1-C oxidation and glucose-C incorporation in adipose tissue were correlated by r = 0.887. Consequences of these results may be of concern in model experiments using dogs.
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D002250:Carbon Radioisotopes; D004247:DNA / Q000032:analysis; D004285:Dogs; D005260:Female; D005947:Glucose / Q000378:metabolism; D007700:Kinetics; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009928:Organ Specificity
D002250:Carbon Radioisotopes; D008055:Lipids; D004247:DNA; D005947:Glucose