title: [Frequency of acrocentric chromosome associations in a long-term human lymphocyte culture].
abstract: The frequency of acrocentric chromosome associations (ACA) in the long-term culture of lymphocytes progressively decreases by 25% (on the average) for one mitotic cycle. As a result proliferous lymphocytes after 3-4 divisions contain either no associations or not more than 2 associating acrocentrics. The diversity of the peripheral blood lymphocytes as to the frequency of ACA in the first mitosis is connected with their different proliferative activity in the organism.
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood; D001973:Bromodeoxyuridine; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002877:Chromosomes, Human / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D008677:Metaphase / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D013997:Time Factors
chemical_list: D010835:Phytohemagglutinins; D001973:Bromodeoxyuridine
vernacular_title: Chastota assotsiatsiĭ akrotsentricheskikh khromosom v dlitel'noĭ kul'ture limfotsitov cheloveka.