title: [Proliferative vitreoretinopathy. Pathogenesis and possibilities for treatment with cytostatic drugs].
abstract: The pathogenesis of proliferative vitreoretinopathy (PVR) is divided into five stages: (1) destruction of the integrity of vitreoretinal structures; (2) cell migration; (3) cell proliferation; (4) cell contraction, and (5) stabilization by synthesis of the extracellular matrix. Current knowledge concerning the treatment of PVR with antiproliferative drugs (5-fluorouracil, Daunomycin) is described.
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects*; D003630:Daunorubicin / Q000627:therapeutic use; D005128:Eye Diseases / Q000188:drug therapy; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D010857:Pigment Epithelium of Eye / Q000187:drug effects; D011743:Pyrimidines / Q000627:therapeutic use; D012164:Retinal Diseases / Q000188:drug therapy*; D014822:Vitreous Body / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D011743:Pyrimidines; D005472:Fluorouracil; D003630:Daunorubicin
vernacular_title: Proliferative Vitreoretinopathie. Pathogenese und Möglichkeiten der Behandlung mit Zytostatika.