A predictable pathophysiological model of porcine hepatic failure.
A technique is described in which acute hepatic failure may be uniformly induced in pigs using a combination of oral phenobarbitone pretreatment and 2-hour interruption of hepatic arterial blood supply followed by intragastric carbon tetrachloride. This results in deep hepatic coma over a narrowly predictable time span and death within 12-52 h. Amino acid levels in plasma and cerebrospinal fluid obtained 24 h after the induction of hepatic failure were similar to those reported in human and experimental encephalopathy.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002251:Carbon Tetrachloride; D004195:Disease Models, Animal; D006499:Hepatic Artery; D006501:Hepatic Encephalopathy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D008026:Ligation; D009336:Necrosis; D010634:Phenobarbital; D013552:Swine
D000596:Amino Acids; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D010634:Phenobarbital