[A study on penetration of mezlocillin into the cerebrospinal fluid].
The concentration of antibiotics in cerebrospinal fluid is of great interest in therapeutics, especially for the treatment of the central nervous system. We studied the penetration of mezlocillin (MZPC) in 3 cases with V-P shunt and 7 cases after neurosurgical operation. After intravenous injection of 4 g MZPC in the 3 cases with V-P shunt, a peak concentration (0.26-3.6 micrograms/ml) of MZPC in the cerebrospinal fluid was reached in 2-4 hours. In the 7 cases after neurosurgical operation, cerebrospinal fluid was sampled at 4 hours after the intravenous injection of 4 g MZPC by spinal tap. Concentrations of MZPC in cerebrospinal fluid ranged from 1.1 to 17.5 micrograms/ml. The mean maximum concentration of MZPC was 5.85 micrograms/ml, which exceeded 90% MIC (minimal inhibitory concentration) against S. epidermidis, E. faecalis, H. influenzae. It is concluded MZPC can be useful for the prophylaxis of meningitis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000601:surgery; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008802:Mezlocillin / Q000008:administration & dosage / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D011184:Postoperative Period
D008802:Mezlocillin