HLA in familial malignant melanoma.
In a family displaying the familial atypical multiple-mole melanoma syndrome, linkage analyses were performed between HLA and an assumed dominant gene respectively determining each of the following affected phenotypes: precursor lesions; cutaneous malignant melanoma (CMM); and precursor lesions or CMM or both. The results suggest that there is a complex mechanism involving several factors, genetic and environmental interacting with the gene determining precursor lesions to cause the neoplastic transformation.
D000293:Adolescent; D000328:Adult; D002471:Cell Transformation, Neoplastic; D004198:Disease Susceptibility; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000276:immunology; D010375:Pedigree; D010641:Phenotype; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D012984:Software
D006680:HLA Antigens