title: [Acute renal insufficiency caused by diflunisal. Description of a case].
abstract: A case of kidney failure in a patient with cirrhosis of the liver in the ascitic stage after treatment of a non-steroid anti-inflammatory drug, diflunisal, is reported. The pathogenesis of the kidney impairment, quickly reversed by withdrawal of the drug, is attributed to pharmacological inhibition of cyclo-oxygenase and prostaglandin synthesis with consequent alterations of intrarenal haemodynamics and renal blood flow.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D004061:Diflunisal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008104:Liver Cirrhosis, Alcoholic / Q000188:drug therapy; D008875:Middle Aged; D012079:Renal Circulation / Q000187:drug effects; D012459:Salicylates / Q000009:adverse effects*
chemical_list: D012459:Salicylates; D004061:Diflunisal
vernacular_title: Insufficienza renale acuta da diflunisal. Descrizione di un caso.