Observations on mouse-infective stocks of Cowdria ruminantium: attempts to demonstrate antigenic changes of the Kwanyanga stock in mice.
Starting from a stabilate of caprine blood infected with the Kwanyanga stock of Cowdria ruminantium, eight serial passages were made in groups of mice, and eight parallel serial passages in goats. Cross-immunity tests in goats and mice failed to demonstrate any difference between stabilates made after the eighth passage. The Kwanyanga stock was of exceptionally low virulence for Dutch goats.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D006041:Goats / Q000382:microbiology*; D006357:Heartwater Disease / Q000276:immunology / Q000635:transmission*; D051379:Mice; D012287:Rickettsiaceae / Q000276:immunology* / Q000472:pathogenicity; D014774:Virulence
D000942:Antigens, Bacterial