title: Relative reliability of three different discriminant analysis methods for detecting PKU gene carriers.
abstract: A previously derived discriminant function for detecting classical PKU gene carriers without a priori pedigree probability was reevaluated using a large sample size. The test involves fluorometric measurement of fasting phenylalanine and tyrosine plasma levels. Among 75 controls and 45 known carriers, 95% could be classified as to their carrier status with greater than 98% accuracy. The accuracy of our method in classifying our population compared favorably to that of two other discriminant analysis methods requiring a priori probability.
mesh_terms: D001699:Biometry; D005215:Fasting; D006580:Genetic Carrier Screening / Q000379:methods*; D006801:Humans; D010649:Phenylalanine / Q000097:blood; D010661:Phenylketonurias / Q000097:blood / Q000235:genetics*; D014443:Tyrosine / Q000097:blood
chemical_list: D014443:Tyrosine; D010649:Phenylalanine