What is the maximal effective dose of caerulein in stimulating pancreatic secretion in man?
The pancreatic exocrine secretory response to increasing doses of exogenous caerulein with and without a background infusion of secretin was studied in 5 healthy volunteers. Caerulein over a full range of doses (2.3-37 pmol/kg/h) produced increasing enzyme secretion up to 18.5 pmol/kg/h, whereas 37 pmol/kg/h was clearly supramaximal and caused submaximal enzyme release. We conclude that maximal pancreatic enzyme secretion is achieved with lower caerulein doses than generally used in pancreatic function tests.
D000328:Adult; D001639:Bicarbonates / Q000378:metabolism; D002108:Ceruletide / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D012633:Secretin / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects; D014357:Trypsin / Q000378:metabolism
D001639:Bicarbonates; D012633:Secretin; D002108:Ceruletide; D014357:Trypsin