Pharmacokinetics and diuretic effect of bumetanide following intravenous and intramuscular administration to horses.
Concentrations of the potent diuretic bumetanide were determined by a sensitive high performance liquid chromatographic procedure in plasma and urine from horses following intravenous and intramuscular administration of a dose rate of 15 micrograms/kg. The elimination half-life was found to be 6.3 min, the volume of distribution at steady state 68 ml/kg and the total plasma clearance 10.9 ml/min/kg. The onset of diuresis occurred within 15 min and diuresis was no longer apparent 1 h after i.v. administration. Given by the intramuscular (i.m.) route, bumetanide was rapidly absorbed; bioavailability was 70-80%. i.m. administration of bumetanide prolonged its plasma half-life (11-27 min) and enhanced and prolonged its diuretic effect.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002034:Bumetanide / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology*; D005260:Female; D006736:Horses / Q000378:metabolism*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D011485:Protein Binding
D001798:Blood Proteins; D004232:Diuretics; D002034:Bumetanide