Female pseudohermaphroditism in a neonate born to a mother with polycystic ovarian disease.
A newborn with female pseudohermaphroditism (profound masculinization of the external genitalia and preservation of the internal female genitalia) is presented. During pregnancy progressive hirsutism was noted in the mother, and polycystic ovaries were found at cesarean section. The serum testosterone level in the cord blood was elevated markedly (1,232 ng./dl). After birth the serum testosterone levels of the mother and newborn decreased dramatically. Over-all it appears that the polycystic ovaries were the source of the excessive androgen secretion that caused maternal and fetal masculinization during the pregnancy.
D012734:Disorders of Sex Development / Q000209:etiology*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D013739:Testosterone / Q000097:blood*
D013739:Testosterone