Platelet dysfunction in splenectomized patients with hairy cell leukemia.
Platelet function was assessed in 17 patients with hairy cell leukemia who had undergone splenectomy. Defective PAF-induced aggregation and selective reduction of beta-thromboglobulin were found in platelets from six and eight patients respectively. These defects were not necessarily associated with bleeding complications.
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010979:Platelet Function Tests / Q000379:methods; D013156:Splenectomy