title: Glutamic acid decarboxylase activity in micropunches of the deep cerebellar nuclei of the genetically dystonic (dt) rat.
abstract: Glutamic acid decarboxylase (GAD) activity was measured in specific divisions of the deep cerebellar nuclei of rats with an inherited dystonia. In 16-day-old dystonic rats there was a significant increase in GAD activity only in the nucleus interpositus (+26%). In 20-day-old dystonic rats GAD activity in all 3 cerebellar nuclei (fastigial, interpositus, dentate) was significantly increased compared to normal controls. The results indicate a spread of the anatomical locus of the neurochemical abnormality with time. During this period (postnatal days 16-20) there is a progressive worsening of the motor disorder in the affected animals.
mesh_terms: D000818:Animals; D002529:Cerebellar Nuclei / Q000201:enzymology* / Q000254:growth & development; D004421:Dystonia / Q000201:enzymology* / Q000235:genetics; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D051381:Rats; D011922:Rats, Mutant Strains
chemical_list: D005968:Glutamate Decarboxylase