Plasma-cell granuloma producing calcitriol and hypercalcemia.
A teenage boy presented with hypercalcemia and a large intrathoracic mass. Results of an extensive evaluation, including normal findings on parathyroid hormone and urinary 3', 5'-cyclic adenosine monophosphate assays, failed to explain his hypercalcemia. During surgery, a large plasma-cell granuloma of the right middle and lower lobes was resected. Within 2 weeks, serum calcium levels returned to normal. Serum calcitriol (1,25-dihydroxyvitamin D3) levels were elevated before surgery and decreased to normal afterward, correlating with the serum calcium level. Homogenates of the plasma-cell granuloma synthesized a compound indistinguishable from calcitriol.
D000293:Adolescent; D002117:Calcitriol / Q000096:biosynthesis*; D005350:Fibroma / Q000150:complications / Q000378:metabolism*; D006660:Histoplasmosis / Q000150:complications; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D008172:Lung Diseases, Fungal / Q000150:complications; D008175:Lung Neoplasms / Q000150:complications / Q000378:metabolism*; D008297:Male
D002117:Calcitriol