[Effect of thymalin on thrombocyte aggregation and the antiaggregation activity of the vascular wall in intact and thymectomized rats].
Administration of immunomodulator thymalin to intact rats was shown to produce reduction of platelet aggregation ability and to exert no effect on antiaggregation activity of the aorta. Thymectomy resulted in an increase of platelet number and their aggregation ability and an increase of antiaggregation activity of the vessel wall in the rats. Thymalin administration to thymectomized rats normalizes platelet hemostasis parameters. The role of the thymus in the regulation of platelet hemostasis is discussed.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology*; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D013934:Thymectomy; D013950:Thymus Gland / Q000502:physiology*; D013951:Thymus Hormones / Q000494:pharmacology*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D013951:Thymus Hormones; C032805:thymalin
Vliianie timalina na agregatsiiu trombotsitov i antiagregatsionnuiu aktivnost' sosudistoĭ stenki u intaktnykh i timéktomirovannykh krys.