[Cytoarchitectonics of the hematoparenchymal barrier of the normal liver and in disordered bile outflow].
When 56 patients suffering from obstructive jaundice and 30 white rats with a model of mechanical jaundice have been investigated, several types of cells, undergoing certain changes at the pathological state, have been revealed in the hepatic capillary walls. After 10 days of the disturbed bile outflow, in the endothelial cells micropinocytosis increases, and satellite reticuloendotheliocytes (Kupffer cells), evidently, already at early stages of jaundice actively participate in rendering harmless bile components. Formation and renovation of the hepatic reticular carcass are connected with function of fat-containing cells. Development of intralobular fibrosis of the liver after 20 days of jaundice in patients and after 10 days of jaundice in the experiment depends on a sharp activation of fibroblast-like cells. Two successively arranged links of the cells are revealed: endotheliocytes and satellite reticuloendotheliocytes, directly participating in formation of the sinusoid wall and in transcapillary metabolism, and perisinusoid cells, situating in the perisinusoid space (Disse). They contain fat-cells, fibroblast-like cells and niche-cells.
D000818:Animals; D002196:Capillaries / Q000166:cytology; D002779:Cholestasis / Q000473:pathology*; D003239:Connective Tissue Cells; D004727:Endothelium / Q000166:cytology; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000166:cytology*; D008854:Microscopy, Electron; D051381:Rats; D013997:Time Factors
Tsitoarkhitektonika gematoparenkhimatoznogo bar'era pecheni v norme i pri narushenii ottoka zhelchi.