[Changes in the kinetic characteristics of reactions catalyzed by erythrocyte delta-aminolevulinate dehydratase in experimental lead poisoning in rats].
An increase in values of both kinetic parameters (Km and Vmax) of the delta-aminolevulinate dehydratase reaction was observed in blood of rats poisoned with lead. The Km value of the reaction was increased, while Vmax--decreased, after addition of Pb2+ into rat blood in vitro. The results obtained as well as the data published in literature suggest that a compensatory mechanism appears to function in vivo, where a substrate, delta-aminolevulenic acid, plays a triggering role.
D000622:Aminolevulinic Acid / Q000097:blood; D000818:Animals; D002384:Catalysis; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D007700:Kinetics; D007855:Lead Poisoning / Q000097:blood / Q000201:enzymology*; D000623:Porphobilinogen Synthase / Q000037:antagonists & inhibitors / Q000097:blood*; D051381:Rats
D000622:Aminolevulinic Acid; D000623:Porphobilinogen Synthase
Izmenenie kineticheskikh kharakteristik reaktsii, kataliziruemoĭ delta-aminolevulinatdegidratazoĭ éritrotsitov, pri éksperimental'no svintsovoĭ intoksikatsii u krys.