title: Some effects of pimozide and of shifts in sucrose concentration on lick rate, duration, and interlick interval.
abstract: Multiple dependent measures were employed to characterize the licking behavior of rats exposed to shifts in reward magnitude or injected with pimozide (PIM). Nondeprived rats licked either a 32% (n = 14) or 4% (n = 15) sucrose solution in daily 10 min sessions. Rats in the 32% condition were then down-shifted to either a 16% (n = 7) 4% (n = 7) sucrose solution. Rats in the 4% condition were up-shifted to either 16% (n = 7) or 32% (n = 8) sucrose solution. The response profiles generated by those rats shifted to a lower reward magnitude were contrasted with either rats shifted from a 32% sucrose solution to a no-reward (plain tap water) condition, or with rats maintained on a 32% sucrose solution and administered the neuroleptic PIM (0.5 mg/kg or 1.0 mg/kg). Rats down-shifted from a 32% to 4% sucrose solution generated response profiles more similar to rats shifted to plain tap water than rats maintained on a 32% sucrose solution and administered PIM. These results suggested that PIM treatment is not functionally equivalent to either a shift to no-reward or to a shift to reduced reward conditions.
mesh_terms: D000818:Animals; D005108:Extinction, Psychological / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D010868:Pimozide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012201:Reward; D013395:Sucrose
chemical_list: D010868:Pimozide; D013395:Sucrose