[Phospholipid restoration of microsome membranes damaged by Fe2+--ascorbate-dependent lipid peroxidation].
The incubation of microsomes damaged by Fe2+--ascorbate-dependent lipid peroxidation with phosphatidylcholine liposomes and micelles is accompanied by the rate decrease of the reduced cytochrome P450 inactivation in microsome membranes. It indicates the elimination of lipid bilayer injuries. The results of study of the saturation degree, surface charge and size of liposomes and micelles influence on the ability to reconstruct the damaged lipid bilayer are presented.
D001205:Ascorbic Acid / Q000494:pharmacology*; D065607:Cytochrome P-450 Enzyme Inhibitors; D005296:Ferrous Compounds / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000187:drug effects* / Q000378:metabolism; D008051:Lipid Bilayers / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism / Q000494:pharmacology*; D008081:Liposomes / Q000494:pharmacology; D008823:Micelles; D008854:Microscopy, Electron; D008861:Microsomes / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010713:Phosphatidylcholines / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism / Q000494:pharmacology*
D065607:Cytochrome P-450 Enzyme Inhibitors; D005296:Ferrous Compounds; D008051:Lipid Bilayers; D008054:Lipid Peroxides; D008081:Liposomes; D008823:Micelles; D010713:Phosphatidylcholines; D010743:Phospholipids; D001205:Ascorbic Acid
Vosstanovlenie fosfolipidami membran mikrosom, povrezhdennykh Fe2+--askorbat-zavisimym perekisnym okisleniem lipidov.