[Reactogenic properties and immunogenicity of measles and mumps vaccines when used by different procedures].
In the controlled epidemiological trial the reactogenic and immunogenic properties of live measles vaccine (LMV) and live parotitis vaccine (LPV) were evaluated in identical groups of children immunized in accordance with different schedules: only LMV or LPV, the injection of these preparations mixed in one syringe or with the use of separate syringes, or at an interval of 3 months. The highest number of febrile reactions, rash and catarrhal symptoms was registered among children immunized with LMV, and the lowest number of such reactions in the groups of children immunized with LPV. The injection of LMV and LPV with one syringe or simultaneously with separate syringes decreased the intensity of immune response to the injection of the antigens. Immunization against measles and parotitis by the injection of monopreparations at an interval of 3 months is believed to be most expedient.
D000914:Antibodies, Viral / Q000032:analysis; D000918:Antibody Specificity; D001831:Body Temperature / Q000187:drug effects; D006801:Humans; D007114:Immunization / Q000379:methods; D007223:Infant; D008458:Measles Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D008459:Measles virus / Q000276:immunology; D009108:Mumps Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D009109:Mumps virus / Q000276:immunology; D013997:Time Factors
D000914:Antibodies, Viral; D008458:Measles Vaccine; D009108:Mumps Vaccine
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