Derivatives of 2-N-arylalkylamino-2-methyl-1-propanol with antiarrhythmic activity.
Several aryl derivatives of achiral 2-amino-2-methyl-1-propanol have been obtained and tested for prophylactic and curative activity in different types of experimental arrhythmia. Interesting results were obtained for compounds 3 and 4 with activity and toxicity similar to those of quinidine.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D011412:Propanolamines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D000889:Anti-Arrhythmia Agents; D011412:Propanolamines