Degradation of cardiac structural proteins induced by reperfusion in the infarcted myocardium.
A combination of 2 h-occlusion and 22 h-reperfusion of the left circumflex coronary artery caused degradation of myosin heavy chain, alpha-actinin, troponin-I and myosin light chain 1 in the infarcted myocardial tissues in dogs. This degradation pattern of myocardial proteins differs from that observed in the dog with 24 h-occlusion.
D000185:Actinin / Q000378:metabolism; D000818:Animals; D003327:Coronary Disease / Q000378:metabolism*; D004285:Dogs; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D005260:Female; D008297:Male; D009124:Muscle Proteins / Q000032:analysis*; D009206:Myocardium / Q000378:metabolism*; D009218:Myosins / Q000032:analysis / Q000378:metabolism; D010477:Perfusion; D013997:Time Factors; D014335:Tropomyosin / Q000378:metabolism; D014336:Troponin / Q000378:metabolism; D019210:Troponin I
D009124:Muscle Proteins; D014335:Tropomyosin; D014336:Troponin; D019210:Troponin I; D000185:Actinin; D009218:Myosins