Yohimbine potentiates the anticataleptic action of clonidine against perphenazine-induced catalepsy in rats.
The modulatory role of clonidine and yohimbine on the perphenazine-induced catalepsy was studied in rats. Perphenazine (5 mg/kg) produced severe catalepsy which lasted for more than 4 hr. Clonidine (50 micrograms/kg), an alpha 2-agonist, pretreatment offered protection against perphenazine-induced catalepsy. On the other hand yohimbine (5 mg/kg), an alpha 2-antagonist, pretreatment not only showed per se protective action but also potentiated the effects of clonidine against perphenazine-induced catalepsy. Yohimbine also potentiated the protective action of quipazine, a serotonin agonist. The protective effect of yohimbine is explained on the basis of its serotoninergic action.
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced / Q000517:prevention & control*; D003000:Clonidine / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D010546:Perphenazine; D011814:Quipazine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D015016:Yohimbine / Q000494:pharmacology*
D015016:Yohimbine; D011814:Quipazine; D010546:Perphenazine; D003000:Clonidine