title: Escape behavior produced by the blockade of glutamic acid decarboxylase (GAD) in mesencephalic central gray or medial hypothalamus.
abstract: Microinjections into the mesencephalic central gray (CG) or the medial hypothalamus (MH) of three drugs (L-allylglycine, Semicarbazide or 4,5 dihydroxy-isophtalic acid) known to block glutamic acid decarboxylase (GAD) produced a dose-dependent behavioral activation accompanied by jumps. These effects are qualitatively similar to those produced by microinjections of SR 95103 (a GABA-A receptor antagonist) at the same site. These findings suggest that, at both the level of the CG and the MH, gamma-aminobutyric acid (GABA) tonically inhibits a neuronal substrate involved in the generation of flight reactions.
mesh_terms: D000501:Allylglycine / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D005968:Glutamate Decarboxylase / Q000037:antagonists & inhibitors*; D007033:Hypothalamus, Middle / Q000201:enzymology*; D008297:Male; D008636:Mesencephalon / Q000201:enzymology*; D010795:Phthalic Acids / Q000494:pharmacology; D011724:Pyridazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012663:Semicarbazides / Q000494:pharmacology; D013997:Time Factors
chemical_list: D010795:Phthalic Acids; D011724:Pyridazines; D012663:Semicarbazides; D000501:Allylglycine; C015820:4,5-dihydroxyisophthalic acid; C044796:2-(carboxy-3'-propyl)-3-amino-4-methyl-6-phenylpyridazinium chloride; D005968:Glutamate Decarboxylase