Nitrous oxide and vitamin B12 deficiency interact adversely on rat growth.
The effects of vitamin B12 deprivation and exposure to nitrous oxide were studied in growing rats. A significant synergistic retardation of growth was seen in rats deprived of vitamin B12 and exposed to nitrous oxide for 90 minutes each day.
D000818:Animals; D006128:Growth / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D008297:Male; D009609:Nitrous Oxide / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014805:Vitamin B 12 / Q000378:metabolism; D014806:Vitamin B 12 Deficiency / Q000503:physiopathology*
D009609:Nitrous Oxide; D014805:Vitamin B 12