Effect of splenectomy on circulating haematopoietic progenitors in myelofibrosis.
The effect of splenectomy on peripheral blood CFU-GM and BFU-E numbers was studied in a patient with myelofibrosis. The numbers of CFU-GM and BFU-E were twice as high in the splenic venous blood as in the peripheral blood. The number of CFU-GM in peripheral blood decreased to 20% and that of BFU-E to 7% of the presplenectomy level at 1 wk after the operation. The progenitor numbers recovered to reach the presplenectomy level within 4-6 w after splenectomy. This effect of splenectomy was different from that seen in 3 patients with Hodgkin's disease, in whom increased numbers of progenitors were observed after a small initial notch.
D000368:Aged; D003114:Colony-Forming Units Assay; D004920:Erythropoiesis; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006689:Hodgkin Disease / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008297:Male; D055728:Primary Myelofibrosis / Q000503:physiopathology / Q000628:therapy*; D013156:Splenectomy