[Cimetidine pharmacokinetics].
The pharmacokinetics of cimetidine was studied in 9 patients at a single intravenous (200 mg) and oral (400 mg) administration. The pharmacokinetic parameters at intravenous administration were calculated according to a two-compartment model. The time-concentration curve after oral drug administration had two maxima between 45 min and 2 hrs with approximately equal concentrations of cimetidine. The main pharmacokinetic parameters of cimetidine were calculated as follows: t1/2 beta = 1.7 h, t1/2 alpha = 0.12 h, Vd = 1.0 1/kg, Cis = 0.43 1/kg/h, Cior = 1.2 1/kg/h, bioavailability 36%. At the course treatment (1 g per day) cimetidine concentration before the morning dose on the 6th and 12th days remains at the same level.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D002927:Cimetidine / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000097:blood / Q000188:drug therapy; D013997:Time Factors
D002927:Cimetidine
Farmakokinetika tsimetidina.