Is biliary excretion of paracetamol significant in man?
The extent of biliary excretion of paracetamol and its principal metabolites was studied in 10 healthy adults. Duodenal intubation was performed approximately 12 h after an oral dose of 1 g paracetamol. Duodenal fluid was aspirated following intravenous cholecystokinin, and urine was collected for 12 h after dosing. The mean concentration of the cysteine and glucuronide conjugates in the bile was 253.7 +/- 39.0 micrograms ml-1 (s.e. mean) and 69.3 +/- 15.3 micrograms ml-1, respectively. The mean recoveries of the cysteine and glucuronide conjugates in the bile were 6.0 +/- 1.5 mg and 1.2 +/- 0.41 mg, respectively. The bile is an important route of elimination for the cysteine conjugate and accounts for 19.4 +/- 4.4% of the total excretion of the metabolite. The fate of the biliary excreted conjugates is not known, and needs further investigation.
D000082:Acetaminophen / Q000378:metabolism*; D000328:Adult; D001646:Bile / Q000378:metabolism*; D003545:Cysteine / Q000032:analysis; D005260:Female; D005965:Glucuronates / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged
D005965:Glucuronates; D000082:Acetaminophen; D003545:Cysteine