Cefuroxime axetil for treatment of uncomplicated gonorrhea.
Oral cefuroxime axetil (1 g) plus probenecid cured 29 of 30 urethral and 6 of 6 rectal gonococcal infections in men; alone the drug cured 22 of 23 urethral and 4 of 6 rectal infections. No toxicity was observed. Cefuroxime axetil alone is effective for urethral gonorrhea in males; rectal gonorrhea probably requires additional probenecid.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use; D002444:Cefuroxime / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002511:Cephalosporins; D004359:Drug Therapy, Combination; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011339:Probenecid / Q000627:therapeutic use; D011897:Random Allocation; D012002:Rectal Diseases / Q000188:drug therapy; D014526:Urethritis / Q000188:drug therapy
D002511:Cephalosporins; D000658:Amoxicillin; D002444:Cefuroxime; D011339:Probenecid; C040738:cefuroxime axetil