Effect of amitriptyline on laminar differentiation of neonatal rat olfactory bulb.
Amitriptyline (AT) was injected i.p. (0.01 g/kg) into newborn rats for 12 days. Stereometric measurements of coronal sections of the olfactory bulbs showed that the area of the external plexiform layer (EPL) in the AT-treated group was significantly smaller than that of control rats. Rats treated with AT also showed a significantly lower increase in body weight compared with the saline-injected control group.
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D002799:Cholinergic Fibers / Q000187:drug effects; D009830:Olfactory Bulb / Q000187:drug effects / Q000254:growth & development*; D051381:Rats; D011919:Rats, Inbred Strains
D000639:Amitriptyline