Liquid chromatographic determination of flucytosine in capsules.
A liquid chromatographic method has been developed for determination of flucytosine in capsules. Flucytosine and p-aminobenzoic acid, the internal standard, are separated on a C18 reverse phase column using water-methanol-acetic acid mobile phase containing 1-octane-sulfonic acid sodium salt. Compounds are detected photometrically at 285 nm. Mean assay results for 250 and 500 mg commercial capsules were 101.5% (n = 5) of declared, respectively. Mean recovery of flucytosine added to commercial capsules was 99.3%.
D002214:Capsules; D002853:Chromatography, Liquid / Q000379:methods; D005437:Flucytosine / Q000032:analysis*; D007202:Indicators and Reagents
D002214:Capsules; D007202:Indicators and Reagents; D005437:Flucytosine