title: The ultrastructure of the myocyte in different regions of experimental infarcts in the cat heart.
abstract: The ultrastructure of myocytes was studied in the left ventricular myocardium of the cat heart after 3 h of LAD ligation. The ischemic, borderline, and normally perfused myocardium was defined by in vivo injection of fluorescein and by regional myocardial blood flow measurements with 15.5 microns radio-labeled microspheres. A semiquantitation of the number of irreversible injured cells in per cent of total counted in the three different zones showed that 53%-63% were irreversibly injured in the ischemic zone, 7%-26% in the borderline area, while none were irreversibly injured in the normally perfused myocardium. The interior excitation-contraction couplings in the normally perfused myocardium comprise interior dyads, triads, reversed triads, and encircling couplings. While the couplings in general were structurally resistant to ischemia, injured interior couplings were apparent in severely damaged cells of the hypoperfused tissue. Such injuries comprise a widening of the junctional gap and a disintegration of the junctional processes.
mesh_terms: D000818:Animals; D002415:Cats; D003326:Coronary Circulation; D003331:Coronary Vessels; D005260:Female; D006439:Hemodynamics; D008026:Ligation; D008297:Male; D008929:Mitochondria, Heart / Q000648:ultrastructure; D009203:Myocardial Infarction / Q000473:pathology* / Q000503:physiopathology; D009206:Myocardium / Q000648:ultrastructure*; D012508:Sarcolemma / Q000648:ultrastructure