[Effect of human somatotropin on metabolism in hypothalamo-hypophyseal nanism patients].
The effect of pharmacopoeic human somatotropin (HS) produced by the Kaunas plant of endocrine preparations, on the proteic, lipid, carbohydrate and mineral metabolism was studied in 40 patients with hypothalamohypophyseal nanism (HHN). The experiments were performed before treatment on an empty stomach, 4 hs after HS administration in a dose of 4 I. U. and during the course of treatment (with 1-2 or 3-4 monthly intervals). The HS administration resulted in the increase of urea, phosphorus and alkaline phosphatase levels, decreased those of beta-lipoproteins, potassium and sodium and caused the redistribution of proteic fractions in the blood of HHN patients. Simultaneous reduction of the urea, creatinine and phosphoric excretion in lime with enhanced urinary excretion of potassium was observed. During a long-term intermittent HS therapy no changes were revealed in carbohydrate metabolism in HHN patients.
D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D002648:Child; D004341:Drug Evaluation; D004393:Dwarfism, Pituitary / Q000188:drug therapy* / Q000378:metabolism; D004573:Electrolytes / Q000652:urine; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007027:Hypothalamic Diseases / Q000188:drug therapy* / Q000378:metabolism; D008055:Lipids / Q000097:blood; D013997:Time Factors
D001798:Blood Proteins; D004573:Electrolytes; D008055:Lipids; D013006:Growth Hormone
Vliianie somatotropina cheloveka na obmen veshchestv u bol'nykh gipotalamo-gipofizarnym nanizmom.