A preliminary study of corneal penetration of 125I-labelled idoxuridine liposome.
We compared corneal penetration of idoxuridine (IDU) to liposome-encapsulated IDU. Liposomes of phosphatidic acid, phosphatidyl choline, and alpha-tocopherol in a molar ratio 1:8:1 were prepared using the reverse phase evaporation method. New Zealand albino rabbits received either 0.1% solution of I125-labelled aqueous IDU or liposome-encapsulated IDU topically every 2 min for 6 min. Corneal, aqueous, and vitreous samples were assayed for I125 radioactivity at 15 min and at 1, 2, 3, and 6 h following drug application. Our results indicated that corneal penetration of liposomal IDU was significantly increased over the regular form of the drug for a time interval of 6 h.
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D003315:Cornea / Q000378:metabolism*; D007065:Idoxuridine / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008081:Liposomes / Q000008:administration & dosage*; D011817:Rabbits; D014822:Vitreous Body / Q000378:metabolism
D007457:Iodine Radioisotopes; D008081:Liposomes; D007065:Idoxuridine