Diazepam inhibits proliferation of the mouse spleen lymphocytes in vitro.
The effects of diazepam (1-100 microM) on the incorporation of 3H-thymidine into DNA of the mouse spleen lymphocytes in vitro have been investigated. A dose-dependent inhibition of lymphocyte DNA synthesis has been found. A 70% inhibition occurred with 100 microM diazepam concentration.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D003864:Depression, Chemical; D003975:Diazepam / Q000494:pharmacology*; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology; D013936:Thymidine / Q000378:metabolism
D004247:DNA; D003975:Diazepam; D013936:Thymidine