title: Susceptibility of Campylobacter pyloridis to three macrolide antibiotics (erythromycin, roxithromycin [RU 28965], and CP 62,993) and rifampin.
abstract: The presence of Campylobacter pyloridis in the gastric mucosa was recently linked to peptic ulcer disease. This study compared the inhibitory activity of three macrolide compounds (erythromycin, roxithromycin [RU 28965], and CP 62,993) and rifampin against 10 clinical isolates of C. pyloridis. The macrolides were equally effective against the test strains, with MICs ranging from 0.06 to 0.5 microgram/ml; rifampin was less active, with MICs ranging from 0.25 to greater than 1 microgram/ml. Erythromycin and the two new macrolide derivatives are potentially useful agents in the treatment of infections caused by C. pyloridis.
mesh_terms: D000328:Adult; D002167:Campylobacter / Q000187:drug effects*; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D007933:Leucomycins / Q000494:pharmacology*; D012293:Rifampin / Q000494:pharmacology*
chemical_list: D007933:Leucomycins; D004917:Erythromycin; D012293:Rifampin