Prefrontal unit activity during delayed conditional Go/No-Go discrimination in the monkey. II. Relation to Go and No-Go responses.
Three monkeys were trained to perform a Go/No-go discrimination task where the animals were required to perform a muscular movement (Go) or to withhold it (No-go) depending on the previously presented signal. Single unit activity was recorded from the prefrontal cortex during the performance of the task. Among 512 task-related prefrontal units, 253 units showed differential activity in relation to the type of the trial (Go or No-go) either at the time of the response or both during the preparatory period for the response and at the time of the response. These units were classified into 3 types depending on whether the changes in unit activity were observed selectively on Go trials (Go units, n = 47), or selectively on No-go trials (No-go units, n = 28) or on both Go and No-go trials (Go/No-go units, n = 178). A small number of units from the premotor cortex (n = 31) were examined inadvertently and the 3 types of units were present in this area as well. The existence of the 3 types of prefrontal units (Go, No-go and Go/No-go) indicates that the prefrontal cortex is involved in the behavioral inhibitory mechanism besides participating in the behavioral excitatory mechanism.
D000818:Animals; D001132:Arm; D002540:Cerebral Cortex / Q000502:physiology*; D003216:Conditioning, Operant; D004193:Discrimination Learning; D004576:Electromyography; D005260:Female; D008253:Macaca mulatta; D008297:Male; D009043:Motor Activity; D009044:Motor Cortex / Q000502:physiology*; D009132:Muscles / Q000294:innervation / Q000502:physiology