title: An influenza virus inhibitor that acts late in the replication cycle.
abstract: An inhibitor which is active against influenza A virus was found in Neuramide, a complex tissue extract that is used as an anti-herpes zoster virus treatment. Kinetic studies showed that significant inhibition of virus production occurred when the inhibitor was added to infected cultures up to 5 h after virus penetration. Molecular sieving fractionation showed that the antiviral activity was contained in a low-molecular-weight fraction (molecular weight, less than 1,000).
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides; D000998:Antiviral Agents; D002478:Cells, Cultured; D002642:Chick Embryo; D009980:Influenza A virus / Q000187:drug effects* / Q000502:physiology; D010455:Peptides / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D023181:Antimicrobial Cationic Peptides; D000998:Antiviral Agents; D010455:Peptides; C039202:neuramide