The rabbit ear-withdrawal test: a new analgesiometric procedure.
The latency to movement of an ear exposed to radiant heat was prolonged after intravenous administration of morphine to rabbits. The quantification of this response in a relatively inactive species that is especially suited for long term and repeated tests suggests that the rabbit ear-withdrawal test will be useful for screening analgesic/anesthetic compounds.
D000698:Analgesia / Q000592:standards; D000700:Analgesics; D000758:Anesthesia / Q000592:standards; D000777:Anesthetics; D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D008297:Male; D009020:Morphine / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy*; D011817:Rabbits
D000700:Analgesics; D000777:Anesthetics; D009020:Morphine