Comparison by studies in squirrel monkeys, chimpanzees, and adult humans of avian-human influenza A virus reassortants derived from different avian influenza virus donors.
We evaluated the abilities of three different avian influenza A viruses to attenuate the wild-type human influenza A/Korea/1/82 (H3N2) virus in squirrel monkeys, chimpanzees, and adult seronegative human volunteers. Two of these, avian influenza A/Mallard/NY/78 and A/Mallard/Alberta/76 viruses, appeared to be satisfactory donors of attenuating genes for the production of live influenza A reassortant virus vaccines for human use because the reassortants exhibited an acceptable balance between attenuation and immunogenicity.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D006801:Humans; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D007252:Influenza Vaccines / Q000276:immunology*; D002679:Pan troglodytes; D011995:Recombination, Genetic; D012453:Saimiri; D014613:Vaccines, Attenuated; D014779:Virus Replication
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated