[Etiologic diagnosis of congenital hypothyroidism and plasma thyroglobulin].
Plasma thyroglobulin (Tg) measurement at the time of screening has a great value in the classification of congenital thyroid defects. Tg was measured in a group of 100 children with congenital hypothyroidism (athyreosis n = 15, ectopic n = 59, eutopic n = 26). Tg was undetectable in athyreosis. These values were significantly different (2.46 +/- 2.52 ng/ml) from those in the group of ectopic (111 +/- 139 ng/ml) and in the group of eutopic (196 +/- 312.1 ng/ml). Four patients with eutopic glands had non measurable Tg and may represent cases with congenital Tg defect.
D003409:Congenital Hypothyroidism; D006042:Goiter / Q000151:congenital; D006801:Humans; D007037:Hypothyroidism / Q000097:blood; D007223:Infant; D013954:Thyroglobulin / Q000096:biosynthesis / Q000097:blood* / Q000172:deficiency; D013961:Thyroid Gland / Q000002:abnormalities; D013972:Thyrotropin / Q000502:physiology; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D013972:Thyrotropin; D013954:Thyroglobulin; D013974:Thyroxine
Diagnostic étiologique de l'hypothyroïde congénitale et thyroglobuline plasmatique.