[Localization of binding sites in rat muscles and brain for cobra neurotoxin and serum immunoglobulins from patients with myasthenia].
Using the immunohistochemical technique, it was revealed that serum immunoglobulins of patients with myasthenia gravis (Ig) were irreversibly attached to the myoneuronal connections of the rat intercostal muscles like the marker of the nicotin cholinireceptors--the cobra venom neurotoxin (CT). In addition, Ig differs from CT in the binding to nervous cells of the claustrum and diencephalon reticular formation and with certain cells of the nucleus caudatus and hemispheric cerebral cortex. It is suggested that the autoimmune processes in patients with myasthenia gravis do not only involve myoneuronal connection but also participate in central mechanisms of the disease genesis.
D000818:Animals; D001665:Binding Sites; D001666:Binding Sites, Antibody; D001921:Brain / Q000378:metabolism*; D003039:Cobra Neurotoxin Proteins / Q000378:metabolism*; D004546:Elapid Venoms / Q000378:metabolism*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism*; D009157:Myasthenia Gravis / Q000276:immunology / Q000503:physiopathology*; D009469:Neuromuscular Junction / Q000378:metabolism; D051381:Rats
D003039:Cobra Neurotoxin Proteins; D004546:Elapid Venoms; D007074:Immunoglobulin G
Lokalizatsiia v myshtsakh i golovnom mozge krys mest sviazyvaniia neĭrotoksina kobry i immunoglobulinov syvorotki krovi bol'nykh miastenieĭ.