Exclusion of an interactive effect of combined x-irradiation and activated cyclophosphamide in tissue culture.
The effect of Cyclophosphamide (CY) on the X ray survival of clonogenic tumor cells has been studied in vitro. Two activated derivatives of the drug, Peroxycyclophosphamide and Hydroperoxycyclophosphamide, were employed. Two cell lines, repair-competent human HeLa cells and the repair-deficient rat REQ line, were investigated. Neither form of CY had any effect on the X ray survival curve of either cell line, indicating that any interaction anticipated in vivo could be expected to be additive.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D003520:Cyclophosphamide / Q000031:analogs & derivatives / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D051381:Rats
C008816:4-peroxycyclophosphamide; D003520:Cyclophosphamide; C011272:perfosfamide