title: Sodium arsenite potentiates the clastogenicity and mutagenicity of DNA crosslinking agents.
abstract: To see if sodium arsenite enhances the clastogenicity and the mutagenicity of DNA crosslinking agents, Chinese hamster ovary (CHO) cells and human skin fibroblasts were exposed to cis-diamminedichloroplatinum (II) (cis-Pt(II)) or 8-methoxypsoralen (8-MOP) plus long-wave ultraviolet light (UVA) and then to sodium arsenite. The results indicate that the clastogenicity of cis-Pt(II) and 8-MOP plus UVA are enhanced by the post-treatment with sodium arsenite. Chromatid breaks and exchanges are predominantly increased in doubly treated cells. Furthermore, the mutagenicity of cis-Pt(II) at the hypoxanthine-guanine phosphoribosyl transferase locus is also potentiated by sodium arsenite in CHO cells.
mesh_terms: D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D018053:Arsenites; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects*; D002945:Cisplatin / Q000633:toxicity; D003043:Cocarcinogenesis; D006224:Cricetinae; D003412:Cricetulus; D003432:Cross-Linking Reagents / Q000633:toxicity*; D004247:DNA / Q000032:analysis*; D004357:Drug Synergism; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D006801:Humans; D008730:Methoxsalen / Q000633:toxicity; D009153:Mutagens; D009154:Mutation; D010053:Ovary; D017670:Sodium Compounds
chemical_list: D018053:Arsenites; D003432:Cross-Linking Reagents; D009153:Mutagens; D017670:Sodium Compounds; C017947:sodium arsenite; D004247:DNA; D001151:Arsenic; D002945:Cisplatin; D008730:Methoxsalen