Use of steroidal antiinflammatory drug provides further evidence for a potential role of PAF-acether in bronchial anaphylaxis.
We presently demonstrate that PAF-acether (1-O-alkyl-2-O-acetyl-sn-glycerol-3-phosphoryl-choline) is formed by sensitized guinea pig lungs upon in vitro antigenic challenge. Pretreatment of the animals with a steroidal antiinflammatory drug, budesonide, almost totally suppresses this biosynthesis. Since budesonide inhibits the anaphylactic bronchoconstriction in actively sensitized guinea pigs, these data strongly support the assumption that PAF-acether is a mediator of bronchial anaphylaxis.
D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D001980:Bronchi / Q000503:physiopathology*; D019819:Budesonide; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000276:immunology; D066298:In Vitro Techniques; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D011282:Pregnenediones / Q000494:pharmacology*
D010972:Platelet Activating Factor; D011282:Pregnenediones; D007073:Immunoglobulin E; D019819:Budesonide