Comparison of the actions of bombesin, gastrin-releasing peptide-27, neuromedin B, and gastrin-releasing peptide-10 in causing release of gastrin and gastric inhibitory peptide in rats.
The objective of this study was to compare the gastrin- and gastric inhibitory peptide (GIP)-releasing actions of bombesin, gastrin-releasing peptide (GRP)-27, neuromedin B, and GRP-10 in rats. Both bombesin and GRP-27 are potent stimulants of gastrin and GIP release, whereas neuromedin B and GRP-10 are less effective, on a molar basis.
D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005749:Gastric Inhibitory Polypeptide / Q000097:blood*; D019886:Gastrin-Releasing Peptide; D005755:Gastrins / Q000097:blood*; D008297:Male; D015287:Neurokinin B / Q000031:analogs & derivatives*; D009842:Oligopeptides / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D051381:Rats
D005755:Gastrins; D009842:Oligopeptides; D010446:Peptide Fragments; D010455:Peptides; D005749:Gastric Inhibitory Polypeptide; D019886:Gastrin-Releasing Peptide; C040794:neuromedin C; D015287:Neurokinin B; C038393:neuromedin B; D001839:Bombesin