title: [Immunological aspects of pulse therapy in systemic lupus erythematosus].
abstract: Twenty SLE patients were examined against a background of pulse-therapy with methylprednisolone. The analysis showed that there was a decrease in the CIC concentration, antibodies to native DNA and an increase in the level of C3c and C4 components of the complement against a background of pulse-therapy. A more rapid time course of the CIC level was noted shortly after pulse-therapy as compared to changes in other immunological indices. A dynamic study of immunological indices in SLE against a background of pulse-therapy was appropriate for a clinical assessment and a study of the mechanisms responsible for the therapeutic efficacy of this method.
mesh_terms: D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D015932:Complement C3c; D003181:Complement C4 / Q000032:analysis; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*
chemical_list: D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D003176:Complement C3; D003181:Complement C4; D015932:Complement C3c; D008775:Methylprednisolone
vernacular_title: Immunologicheskie aspekty pul's-terapii pri sistemnoĭ krasnoĭ volchanke.