[Mixed function oxidase isolated from human gastric epithelium in Fujian Province, a high incidence area of stomach cancer, and its role in the metabolism of diethylnitrosamine].
Mixed function oxidase (MFO) was isolated from the mucosa of human stomach in Fujian Province, a high incidence area of stomach cancer. Its activity was analyzed using a modified micromethod. In the non-cancer group, the activity of MFO in high incidence area of stomach cancer was significantly higher than that in low incidence area (P less than 0.001). A significant difference was also observed between stomach cancer and non-cancer groups. But the MFO concentrations between the high and low incidence areas were not different. These results suggest that the high MFO activity in gastric mucosal epithelial cells may cause higher incidence of stomach cancer. MFO isolated from human gastric epithelium is capable of metabolizing directly diethylnitrosamine in vitro.
D002681:China; D004052:Diethylnitrosamine / Q000378:metabolism*; D004848:Epithelium / Q000201:enzymology / Q000473:pathology; D005753:Gastric Mucosa / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D006899:Mixed Function Oxygenases / Q000032:analysis*; D012306:Risk; D013274:Stomach Neoplasms / Q000201:enzymology*
D004052:Diethylnitrosamine; D006899:Mixed Function Oxygenases