Lipid peroxidation induced by N-acetylcysteine in isolated rat hepatocytes.
In isolated rat hepatocytes N-acetylcysteine induces an increase of lipid peroxidation, as evaluated by the malondialdehyde production and diene conjugation. Lipid peroxidation did not result in increased cell mortality. Antioxidants and free radicals scavengers completely protect toward lipid peroxidation induced by N-acetylcysteine.
D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet
D008054:Lipid Peroxides; D008315:Malondialdehyde; D000111:Acetylcysteine