Interactions between cimetidine, methylparathion, and parathion.
The purpose of this study was to determine whether cimetidine exerts a protective effect against toxicity of organophosphate pesticides requiring metabolic activation in mice and rats. In both species, pretreatment with cimetidine (75 mg/kg/ip) 30 min prior to methylparathion (MP) reduced lethality and delayed the onset of cholinergic signs of toxicity. In contrast when cimetidine was administered simultaneously with MP to mice, neither MP-induced lethality nor cholinergic signs of toxicity were altered. Moreover, cimetidine pretreatment failed to decrease parathion-induced toxicity in mice. In conclusion, pretreatment with cimetidine decreases the toxicity of MP but not of parathion in mice and rats.
D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D008743:Methyl Parathion / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D010275:Parasympathetic Nervous System / Q000187:drug effects; D010278:Parathion / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D008743:Methyl Parathion; D010278:Parathion; D002927:Cimetidine