Acute myocardial necrosis during administration of amsacrine.
The authors report a case of focal myocardial necrosis, presenting clinically as an acute myocardial infarction during the administration of the antineoplastic drug, amsacrine, in a patient without coronary artery disease. In addition to the recognized arrhythmic complications, the authors emphasize myocardial necrosis as a possible further manifestation of amsacrine-related cardiotoxicity.
D000609:Aminoacridines / Q000009:adverse effects*; D000677:Amsacrine; D000970:Antineoplastic Agents / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008875:Middle Aged; D009203:Myocardial Infarction / Q000139:chemically induced*; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis / Q000473:pathology
D000609:Aminoacridines; D000970:Antineoplastic Agents; D000677:Amsacrine