Hypoxic-ischemic brain damage and cerebral blood flow changes in young rabbits.
Hypoxic-ischemic cerebral damage was demonstrated in the cerebral cortex of 2-week-old rabbits at 3 to 5 days after bilateral carotid artery ligation and reperfusion during hypoxemia. Carotid ligation and reperfusion had little effect on cortical blood flow during normoxemia, but the former suppressed a blood flow increase to hypoxemia and the latter suppressed a blood flow decrease to hyperoxemia. These results suggest a relative ischemia or vascular dysfunction which may play a part in the pathogenesis of the hypoxic-ischemic cortical necrosis.
D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000098:blood supply* / Q000473:pathology; D005260:Female; D002534:Hypoxia, Brain / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009336:Necrosis; D011817:Rabbits; D012039:Regional Blood Flow