Ultrastructure of the testis in an XX-male with normal plasma testosterone.
Hormonal and ultrastructural examinations of the testis were performed in an XX-male. Plasma levels of testosterone and prolactin were within the normal range, but FSH and LH were higher than the normal range. The response of testosterone to the administration of HCG is within the normal range. In the interstitium marked hyperplasia of Leydig cells was observed. The presence of paracrystalline inclusions and the absence of Reinke's crystals were representative changes in Leydig cells. Seminiferous tubules were filled with Sertoli cells and spermatogenesis was completely abolished. Intermediate filaments were abundant and annulate lamellae were absent in Sertoli cells.
D000328:Adult; D006063:Chorionic Gonadotropin; D006801:Humans; D006965:Hyperplasia; D007985:Leydig Cells / Q000648:ultrastructure; D008297:Male; D011388:Prolactin / Q000097:blood; D012671:Seminiferous Tubules / Q000648:ultrastructure; D012729:Sex Chromosome Aberrations / Q000473:pathology*; D013737:Testis / Q000648:ultrastructure*; D013739:Testosterone / Q000097:blood*
D006063:Chorionic Gonadotropin; D013739:Testosterone; D011388:Prolactin