Genetic influence on increased seizure susceptibility in pregnancy.
In previous studies we have reported that flurothyl-induced clonic seizure threshold was significantly reduced in pregnant mice. In the present study eight strains of mice were tested for flurothyl seizure susceptibility during pregnancy in an effort to find one which lacked this trait. Latency to myoclonus, latency to clonus, and the interval between these seizures were measured. Two inbred strains, A/Ibg and BALB/cByJ, were resistant to the pregnancy-associated increase in seizure susceptibility. These strains will be used, along with others which show the increased seizure trait, to investigate the neurochemical mechanisms which underlie the increased seizure susceptibility in pregnancy.
D000818:Animals; D004198:Disease Susceptibility; D005260:Female; D005481:Flurothyl; D005796:Genes; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D009207:Myoclonus / Q000235:genetics*; D011247:Pregnancy; D011248:Pregnancy Complications; D012640:Seizures / Q000139:chemically induced / Q000235:genetics*
D005481:Flurothyl