Effect of lead on electrophoretic mobility of rat erythrocytes.
Lead often affects the erythrocyte membrane. The relationship between the changes in erythrocyte membrane and the anemia caused by lead is still unclear. Initially, the effect of lead injected intraperitoneally on the electrophoretic mobility of rat erythrocytes was investigated in order to study the relationship between them. As indices of lead exposure, hemoglobin (Hb) levels, hematocrits (Ht), delta-aminolevulinic acid dehydratase (ALA-D) activities and blood lead (blood Pb) levels in the injected rats were also examined. Exposure to lead significantly decreased the mobility of rat erythrocytes. The changes in mobility seemed to be less sensitive than those in ALA-D activity, however, the decreases in mobility were simultaneous with or prior to those in Hb level and Ht. The decreases in mobility were evident to some extent below a blood Pb level of 100 micrograms/100 ml and generally present at a level of 100 micrograms/100 ml and over. In the rats exposed to lead a significant negative correlation was found between the mobilities and the logarithms of blood Pb level.
D000818:Animals; D004586:Electrophoresis; D004912:Erythrocytes / Q000187:drug effects*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007854:Lead / Q000097:blood / Q000494:pharmacology*; D008297:Male; D000623:Porphobilinogen Synthase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D006454:Hemoglobins; D007854:Lead; D000623:Porphobilinogen Synthase