title: Rapid determination of platinum by flameless atomic absorption spectrophotometry following the administration of cisplatin to cancer patients.
abstract: An improved flameless atomic absorption spectrophotometric method for the analysis of platinum in plasma is described. Following a simple dilution with Triton X-100, the sample is directly injected into the graphite furnace with a total analysis time of less than 2 min. The assay is precise (CV less than 4.3%) and linear (r greater than 0.9922) in the ranges 0.05-1 and 1-4 mg/L for cisplatin. The applicability of the method is examined by analyzing samples obtained at different intervals from two patients treated with cisplatin.
mesh_terms: D002945:Cisplatin / Q000378:metabolism / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000188:drug therapy; D010984:Platinum / Q000097:blood*; D013054:Spectrophotometry, Atomic
chemical_list: D010984:Platinum; D002945:Cisplatin