title: Influence of intraperitoneally administered formaldehyde on bile production and tissue glutathione levels in rats.
abstract: The influence of formaldehyde on bile secretion and tissue glutathione concentrations was investigated in male Sprague Dawley rats following a sublethal intraperitoneal administration (72 mg/kg). Within 2-3 h of administration formaldehyde caused a 2-fold increase in secretion of bile and significant decrease in the levels of glutathione in liver (39% of control) followed by kidney (33%), lung (31%) and brain (22%). The results indicate a possible protective role of glutathione in the toxicity of formaldehyde.
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D005557:Formaldehyde / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D005978:Glutathione / Q000032:analysis / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D005557:Formaldehyde; D005978:Glutathione