Identification of pyrilamine metabolites by ammonia chemical ionization mass spectrometry.
The ammonia chemical ionization mass spectrometric analysis of pyrilamine, the N-oxide of pyrilamine, and related compounds is described. The use of ammonia as the reagent gas produced excellent [M + H]+ ions for these compounds. The suitability of this method for the analysis of two rat urinary metabolites of pyrilamine is demonstrated.
D000631:Aminopyridines / Q000378:metabolism*; D000641:Ammonia; D000818:Animals; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D013058:Mass Spectrometry; D011738:Pyrilamine / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344
D000631:Aminopyridines; D000641:Ammonia; D011738:Pyrilamine