Kinetics of methaemoglobin production. (1). Kinetics of methaemoglobinaemia induced by the cyanide antidotes, p-aminopropiophenone, p-hydroxyaminopropiophenone or p-dimethylaminophenol after intravenous administration.
Methaemoglobin profiles have been studied by using ISIS, a simulation package, and NONLIN, a non-linear least-squares analysis regression program. A simple kinetic model which satisfactorily describes methaemoglobin profiles after p-aminopropiophenone (PAPP) administration and 4-dimethylaminophenol (DMAP) administration has been developed. The two compounds differed mainly in their effective rates of elimination. The model less satisfactorily described methaemoglobin profiles after p-hydroxyaminopropiophenone (PHAPP) administration.
D000627:Aminophenols / Q000494:pharmacology; D000818:Animals; D000931:Antidotes / Q000494:pharmacology; D003198:Computer Simulation; D003486:Cyanides / Q000037:antagonists & inhibitors* / Q000506:poisoning; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D007700:Kinetics; D008706:Methemoglobin / Q000096:biosynthesis*; D008708:Methemoglobinemia / Q000139:chemically induced*; D008954:Models, Biological; D011427:Propiophenones / Q000494:pharmacology
D000627:Aminophenols; D000931:Antidotes; D003486:Cyanides; D011427:Propiophenones; C050745:4-hydroxyaminopropiophenone; C029564:4-aminopropiophenone; D008706:Methemoglobin; C020292:4-dimethylaminophenol