title: Effects of microcosm salinity and organic substrate concentration on production of Vibrio cholerae enterotoxin.
abstract: The effects of aquatic processes on production of cholera toxin by Vibrio cholerae were studied with seawater microcosms. Several salinity and organic nutrient concentrations were employed. At 10 g of organic nutrient per liter of seawater, toxin production increased as the salinity was increased. At lower organic nutrient concentrations, toxin production was markedly enhanced when the salinity was 20 and 25%. Toxin concentration increased with salinity, independent of cell concentration and toxin stability. From the results obtained in this study, it is concluded that physical and chemical parameters of the aquatic environment affect not only the physiological state of V. cholerae, but also its potential pathogenicity.
mesh_terms: D003470:Culture Media; D004768:Enterotoxins / Q000096:biosynthesis*; D007700:Kinetics; D009994:Osmolar Concentration; D012623:Seawater; D013045:Species Specificity; D014734:Vibrio cholerae / Q000378:metabolism*
chemical_list: D003470:Culture Media; D004768:Enterotoxins; C037420:stN protein, Vibrio cholerae