title: Does sucrose damage kidneys?
abstract: There is evidence to suggest that sucrose ingestion can cause renal parenchymal changes as well as increasing the urinary saturation index for calcium oxalate. Ten stone formers and 10 normal subjects received 250 gm of sucrose daily over a period of 7 days. Observations on the risk factors for calcium stone formation and urinary N-acetyl-B-glucosaminidase (NAG), a marker of renal tubular cell damage, were made. Oxalate excretion increased. Urinary calcium levels were unchanged but the pattern of response was different between the two groups, as with magnesium and phosphate. NAG was spontaneously higher in the patient group and increased significantly after sucrose ingestion in both groups.
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D002118:Calcium / Q000652:urine; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007669:Kidney Calculi / Q000652:urine*; D008274:Magnesium / Q000652:urine; D008297:Male; D008875:Middle Aged; D010070:Oxalates / Q000652:urine; D019815:Oxalic Acid; D010710:Phosphates / Q000652:urine; D013395:Sucrose / Q000009:adverse effects*; D014554:Urination
chemical_list: D010070:Oxalates; D010710:Phosphates; D013395:Sucrose; D019815:Oxalic Acid; D000118:Acetylglucosaminidase; D008274:Magnesium; D002118:Calcium