Oxytocin and [1-deamino, 8-D-arginine]-vasopressin (dDAVP): intrathecal effects on blood pressure, heart rate and urine output.
Two analogues of arginine vasopressin (AVP) were administered intrathecally in rats. Neither oxytocin (OXT) nor [1-deamino, 8-D-arginine]-vasopressin (dDAVP) were as potent as AVP in inducing changes in cardiovascular function and renal output. Large doses of OXT, however, did cause significant changes in pressor responses and urine output, suggesting that this peptide may act at spinal levels, possibly as a weak agonist on AVP receptors.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage*; D006339:Heart Rate / Q000187:drug effects*; D007278:Injections, Spinal; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010121:Oxytocin / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D014554:Urination / Q000187:drug effects*
D010121:Oxytocin; D003894:Deamino Arginine Vasopressin