Androgen binding protein levels and FSH binding to testicular membranes in vitamin A deficient rats and during subsequent replenishment with vitamin A.
ABP levels in the testes and epididymides of vitamin A deficient-retinoic acid maintained rats were only 20 and 6% respectively as compared with those in normal rats. The number of FSH receptors in the testes of vitamin A deficient rats, as measured by [125I]ovine FSH binding to isolated testicular membranes, was only 40% of that in the testes of normal rats. Supplementation of retinyl acetate to these vitamin A deficient rats for 16 days resulted in restoration of the number of FSH receptors to normal levels. On the other hand, ABP levels were restored to 32 and 34% only in the testes and epididymides respectively.
D000727:Androgen-Binding Protein / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004822:Epididymis / Q000378:metabolism; D008297:Male; D051381:Rats; D011962:Receptors, FSH / Q000378:metabolism*; D013737:Testis / Q000378:metabolism*; D014801:Vitamin A / Q000627:therapeutic use*; D014802:Vitamin A Deficiency / Q000188:drug therapy / Q000378:metabolism*
D000727:Androgen-Binding Protein; D011962:Receptors, FSH; D014801:Vitamin A