title: Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7.
abstract: Pancreatic polypeptide and neuropeptide Y share 50% amino acid homology (18 out of 36 residues), suggesting that they may have common ancestral origins. cDNA clones complementary to human mRNAs encoding pancreatic polypeptide and neuropeptide Y were used to detect specific human genomic DNA sequences in human-mouse somatic cell hybrid lines. The pancreatic polypeptide gene (PPY) segregated with human chromosome 17, while the neuropeptide Y gene (NPY) segregated with human chromosome 7. Examination of cell hybrids with chromosomal rearrangements assigned PPY to the p11.1-qter region and NPY to the pter-q22 region of their respective chromosomes.
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D002902:Chromosomes, Human, 16-18; D002906:Chromosomes, Human, 6-12 and X; D005796:Genes; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009478:Neuropeptide Y; D009693:Nucleic Acid Hybridization; D010191:Pancreatic Polypeptide / Q000235:genetics*; D011498:Protein Precursors / Q000235:genetics
chemical_list: D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D011498:Protein Precursors; D010191:Pancreatic Polypeptide