Chlorisondamine blocks acquisition of the conditioned taste aversion produced by (-)-nicotine.
Intraventricular microinjection (5 micrograms) of the bisquaternary ganglion-blocking drug chlorisondamine prevented acquisition of nicotine-induced conditioned taste aversion (CTA) in rats. This appeared to be a specific effect because chlorisondamine did not attenuate the conditioned taste aversion caused by apomorphine. These results support findings from other behavioural procedures indicating that centrally administered chlorisondamine causes a long-term blockade of central nicotinic mechanisms.
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology; D001921:Brain / Q000187:drug effects; D002714:Chlorisondamine / Q000008:administration & dosage / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D004347:Drug Interactions; D007276:Injections, Intraventricular; D008297:Male; D008845:Microinjections; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013649:Taste / Q000187:drug effects*
D009538:Nicotine; D002714:Chlorisondamine; D001058:Apomorphine