Graft versus host-like illness in a child with phenobarbital hypersensitivity.
A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described. Laboratory studies demonstrated eosinophilia, elevated serum IgE, and elevated T suppressor/cytotoxic cells in the peripheral blood. Findings from biopsy specimens of skin and jejunum suggested a cell-mediated pathogenesis, and lymphoproliferative studies of the patient's mononuclear cells revealed a positive response to phenobarbital. The clinical findings and laboratory studies suggested an autoimmune cell-mediated hypersensitivity reaction triggered by phenobarbital.
D000936:Antigen-Antibody Complex / Q000032:analysis; D001327:Autoimmune Diseases / Q000139:chemically induced; D001706:Biopsy; D002648:Child; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis*; D006801:Humans; D007583:Jejunum / Q000473:pathology; D010634:Phenobarbital / Q000009:adverse effects*; D012640:Seizures / Q000188:drug therapy; D012867:Skin / Q000473:pathology
D000936:Antigen-Antibody Complex; D010634:Phenobarbital