title: Dilated cardiomyopathy and cocaine abuse. Report of two cases.
abstract: Two young patients with dilated cardiomyopathies associated with long-term use of cocaine are described. A 42-year-old male cocaine abuser with normal coronary arteries experienced recurrent myocardial infarction, with development of a dilated, globally hypocontractile left ventricle. The second patient, a 28-year-old woman with a prominent history of inhaling vaporized cocaine ("free-basing"), presented with symptoms and signs of biventricular heart failure and was found to have a dilated cardiomyopathy. The clinical spectrum of cocaine cardiotoxicity is reviewed, and pathophysiologic mechanisms of cocaine-induced cardiomyopathy are discussed. Long-term cocaine use may cause dilated cardiomyopathy and recurrent myocardial infarction, even in the absence of atherosclerotic epicardial coronary artery disease.
mesh_terms: D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced* / Q000503:physiopathology; D003042:Cocaine; D005260:Female; D006801:Humans; D008297:Male; D012008:Recurrence; D019966:Substance-Related Disorders
chemical_list: D003042:Cocaine