[Characteristics of the action of parlodel on endocrine functions of the body].
The effect of dopamine agonist parlodel (1 and 5 mg/kg) on the activity of the hypothalamic-pituitary-adrenal system, lactotropic and somatotropic pituitary functions was studied. The content of ACTH and corticosterone in the blood and tissue, aldosterone in the blood, prolactin, somatotropic hormone in the pituitary, catecholamines in the hypothalamus and cerebral cortex demonstrated the inhibitory effect of the drug on the functioning of the hypothalamic-pituitary-adrenal system, and pituitary, lactotropic and somatotropic functions. The mode of parlodel action consists probably in the decrease of turnover rather than in any changes of dopamine and catecholamine content in the hypothalamus and cerebral cortex. Parlodel failed to affect steroid metabolism in the body.
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D002395:Catecholamines / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006728:Hormones / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002395:Catecholamines; D006728:Hormones; D001971:Bromocriptine
Osobennosti deĭstviia parlodela na nekotorye éndokrinnye funktsii organizma.