title: Role of glucose reabsorption from bile on hyperglycaemia-induced cholestasis in the rabbit.
abstract: The effect of glucose administration on bile secretion of glucose and bile flow and composition was studied in the rabbit. After intravenous glucose infusion at 83 mumol/kg/min a mean bile concentration of 12.7 +/- 1.8 mg/dl was reached. Intraportal administration of phlorizin enhanced bile glucose concentration to 169.6 +/- 18.1 mg/dl, suggesting the presence of a system for transferring glucose from bile to liver in the biliary tree of the rabbit. A significant correlation between bile flow and plasma glucose levels could be demonstrated. A cholestatic effect appeared in glucose-infused rabbits with a decrease in bile flow by about 40% during the second hour of infusion. Both bile acid and inorganic electrolyte output were significantly lowered. Cholestasis was maintained after phlorizin administration. Possible explanations for this effect are discussed.
mesh_terms: D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D002779:Cholestasis / Q000209:etiology / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D006943:Hyperglycemia / Q000150:complications* / Q000378:metabolism; D008297:Male; D010695:Phlorhizin / Q000494:pharmacology; D011817:Rabbits
chemical_list: D001786:Blood Glucose; D010695:Phlorhizin; D005947:Glucose