[Antioxidant effectiveness in isoniazid-induced lesions of the liver].
In male albino rats tocopherol acetate and sodium selenite were shown to be efficient in treatment of isoniazide-induced liver damage. The disturbances of secretion of bile, bile acids and bilirubin and excretion of cholesterol were less pronounced. A decrease of the activity of marker blood serum enzymes--alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase--also indicated the hepatoprotective effect of these drugs. The intensity of lipoperoxidation indicated by a decrease of lipid peroxidation indices in the liver and blood was diminished. Tocopherol acetate and sodium selenite increase the number of sulfhydryl groups but decrease the number of disulfide groups in these biosubstrates.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D007538:Isoniazid / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008107:Liver Diseases / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D051381:Rats; D020887:Selenious Acid; D012643:Selenium / Q000627:therapeutic use; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000975:Antioxidants; D014810:Vitamin E; D020887:Selenious Acid; D024502:alpha-Tocopherol; D012643:Selenium; D024505:Tocopherols; D007538:Isoniazid
Effektivnost' antioksidantov pri porazhenii pecheni izoniazidom.