Nifedipine-associated acute psychosis.
A 84-year-old man was given nifedipine for control of angina pectoris. Acute psychosis with paranoid ideation developed soon after he began receiving the medication. All symptoms resolved with discontinuation of nifedipine. This is the second reported case of nifedipine-associated acute psychosis. Alternations in calcium-mediated neurotransmitter release, particularly dopamine, may be responsible. Clinicians should consider nifedipine when presented with a patient with acute psychosis.
D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000523:psychology*
D009543:Nifedipine