Demonstration of Kathon CG in some commercial products.
The preservative Kathon CG has become one of the most common sensitizers. It has, however, been difficult to explain the sensitization and to assess the clinical relevance of the contact allergy, partly due to lack of specification of the preservative in products. A high-performance liquid chromatography method was used to demonstrate Kathon CG in 123 commercial products of both "leave on" and "rinse off" types. 38 of these contained Kathon CG in the range of 1-15 ppm of active ingredients. There were no differences between "leave on" and "rinse off" products concerning the relative number of products containing Kathon CG and the concentrations of the preservative.
D000485:Allergens / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D003877:Dermatitis, Contact / Q000209:etiology; D006801:Humans; D010592:Pharmaceutic Aids / Q000032:analysis*; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects / Q000032:analysis* / Q000276:immunology; D013844:Thiazoles / Q000009:adverse effects / Q000032:analysis* / Q000276:immunology
D000485:Allergens; D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical; D013844:Thiazoles; C037057:Kathon 886