Lectin binding to pseudoexfoliative material and the ocular zonules.
Lectin staining of pseudoexfoliative material on the lens capsule, zonules, and iris showed the presence of the beta-D-galactose (1-3) galactosamine sequence, alpha-D-galactosamine, beta-D-galactose, beta-(1-4)-D-glucosamine, and terminal sialic acid. Mono and difucosyl binding sites were also found. The likelihood that the lectins were binding to two different galactosamine-containing moieties was supported by their different distributions in the photoreceptors. These affinities suggest a complex carbohydrate composition in pseudoexfoliative material, with both O-linked sialomucin-type and N-linked oligosaccharide chains.
D000869:Anterior Eye Segment / Q000378:metabolism; D005123:Eye / Q000378:metabolism*; D005128:Eye Diseases / Q000378:metabolism*; D006801:Humans; D007498:Iris / Q000378:metabolism; D007903:Lens Capsule, Crystalline / Q000378:metabolism; D011975:Receptors, Mitogen / Q000378:metabolism*; D013577:Syndrome
D011975:Receptors, Mitogen