Effect of skimmianine on animal behavior.
Skimmianine, a component of Rutaceae plants, was found to have a significant inhibitory effect on spontaneous motor activity, exploratory behavior, cataleptogenic activity, conditioned avoidance response and long-term isolation-induced fighting of animals. A mild antimethamphetamine activity was also observed. Its neuroleptic activity was less potent than that of chlorpromazine.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D002375:Catalepsy / Q000139:chemically induced; D002746:Chlorpromazine / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D010936:Plant Extracts; D011804:Quinolines; D008694:Methamphetamine; C035932:skimmianine; D002746:Chlorpromazine