Effects of lobar pulmonary blood flow on the evolution of oleic acid lung injury in dogs.
We studied the effects of interruption of the pulmonary blood flow to the left diaphragmatic lung lobe on the evolution of canine oleic acid lung injury. We compared the morphology and edema of the left diaphragmatic lobe, whose pulmonary artery was ligated immediately after oleic acid injury, with the right diaphragmatic lobe, in which the blood supply was intact. The injury plus ligation resulted in hypoxemia and pulmonary hypertension with PaO2 falling from 98 +/- 4 to 72 +/- 21 torr (P less than 0.05) and pulmonary artery pressure increasing from 11 +/- 3 to 18 +/- 4 mm Hg (P less than 0.05). Animals were sacrificed 48 hr following the injury. Morphological examination of right and left lobes showed no consistent differences although wet/dry ratios indicated significantly greater edema (P less than 0.01) for the right diaphragmatic lobes (7.66 +/- 1.23) than the left (6.80 +/- 0.59). Both right and left lobes were substantially more edematous than our laboratory normal value of 4.74 +/- 0.54 (P less than 0.001 for both). We conclude that interruption of pulmonary arterial blood flow protects against edema formation in oleic acid injury but does not alter the morphologic evolution of the injury.
D000818:Animals; D001794:Blood Pressure; D001980:Bronchi / Q000098:blood supply; D002199:Capillary Permeability; D004285:Dogs; D006439:Hemodynamics; D007511:Ischemia / Q000150:complications / Q000503:physiopathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000150:complications; D019301:Oleic Acid; D009829:Oleic Acids / Q000633:toxicity*; D011651:Pulmonary Artery; D011652:Pulmonary Circulation
D009829:Oleic Acids; D019301:Oleic Acid