[Survival of clonogenic cells of Lewis lung carcinoma cells forming colonies in agar cultures in diffusion chambers during gamma-irradiation and exposure to gamma-neutron californium-252 irradiation].
Clonogenic cells forming colonies in agar cultures in diffusion chambers and those isolated from subcutaneously transplanted Lewis lung carcinoma do not differ in their sensitivity to 60Co gamma-rays with respect to tumor growth stages. The dose-survival curves for all studied cells are S-shaped with a small shoulder. A cumulative dose-survival curve for malignant clonogenic cells is characterized by the average value of mean lethal dose D0 = 2.24 Gy and extrapolation number n = 2.0. When exposed to gamma-neutron-radiation (252Cf) malignant clonogenic cells exhibit a nearly exponential dose-survival curve with D0 = 0.56 Gy (with respect to a neutron component). The RBE of gamma-neutron radiation (252Cf) is 2.5.
D000818:Animals; D002142:Californium; D002470:Cell Survival / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000473:pathology / Q000528:radiation effects*; D009502:Neutrons; D012062:Relative Biological Effectiveness; D014410:Tumor Stem Cell Assay
D002142:Californium
Vyzhivaemost' klonogennykh kletok karsinomy legkikh L'iuis, formiruiushchikh kolonii v agarovykh kul'turakh v diffuzionnykh kamerakh, pri gamma-obluchenii i vozdeĭstvii gamma-neĭtronnogo izlucheniia kaliforniia-252.