Rapid regulation of [3H]hemicholinium-3 binding sites in the rat brain.
The effects of various drugs known to affect the sodium-dependent high-affinity choline-uptake system (SDHACU) in the brain were examined for their action upon the [3H]hemicholinium-3 [( 3H]HCh-3) binding site, which is associated with the choline carrier. The [3H]HCh-3 binding sites are affected in a similar way to the SDHACU system. Thus, alterations in the velocity of choline-uptake are mediated through changes in the apparent number of available transport sites at cholinergic terminals.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002794:Choline / Q000378:metabolism*; D006426:Hemicholinium 3 / Q000378:metabolism*; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D010276:Parasympatholytics; D006426:Hemicholinium 3; D002794:Choline