Analgesic use by leprosy patients.
We questioned 235 subjects with leprosy regarding the consumption of analgesic preparations, and 46 subjects (19.5%) admitted to having consumed more than 2 kg of analgesics; the main reason for consumption was neuritic pain. The commonly consumed analgesics are paracetamol (acetaminophen) and local proprietary compound analgesics containing aspirin, phenacetin, and caffeine. Intravenous urograms were done on 28 of the 46 subjects, but none showed evidence of renal papillary necrosis. The reasons for this lack of renal papillary necrosis are postulated. Excessive ingestion of analgesics may be a contributory factor in the development of interstitial nephritis in patients with leprosy.
D000082:Acetaminophen / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000009:adverse effects / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007681:Kidney Papillary Necrosis / Q000139:chemically induced; D007918:Leprosy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced; D010615:Phenacetin / Q000009:adverse effects / Q000627:therapeutic use
D000700:Analgesics; D000082:Acetaminophen; D010615:Phenacetin; D001241:Aspirin