Genotoxic effects of ketamine on CHO cells.
Ketamine, a non-barbiturate anaesthetic agent, was studied for its genotoxic potential using the SCE assay. It was genotoxic in the in vitro system at concentrations comparable to the plasma levels achieved during steady state anaesthesia. It had no effects on cellular kinetics in CHO cells.
D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D007649:Ketamine / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens; D010053:Ovary; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D009153:Mutagens; D007649:Ketamine