Fimbria-fornix lesion increases nerve growth factor content in adult rat septum and hippocampus.
Bilateral complete transection of the fimbria-fornix causes a significant increase in nerve growth factor (NGF) content both in the septum and hippocampus of the adult rat as measured by a sensitive immunoassay 7 days after lesioning. The finding, that elevation of NGF in septum (250%) was much more pronounced than that in the hippocampus (30-50%), cannot be explained by retrograde axonal transport. Degeneration of central cholinergic neurons might be a potential trigger for NGF production in the CNS.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002799:Cholinergic Fibers / Q000502:physiology; D005246:Feedback; D005260:Female; D006624:Hippocampus / Q000032:analysis* / Q000502:physiology; D009414:Nerve Growth Factors / Q000032:analysis*; D009434:Neural Pathways / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012688:Septum Pellucidum / Q000032:analysis*
D009414:Nerve Growth Factors; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase