[Changes in the reaction of the cardiovascular system to angiotensin II in pregnancy modified by aspirin].
The experiments were done in pregnant and in nonpregnant rabbits, anesthesized with urethane. Arterial blood pressure was measured directly in carotid artery, estimating changes of blood pressure after infusions and injections of angiotensin II. It was found, that in pregnant rabbits systolic blood pressure and diastolic blood pressure was higher than in non-pregnant animals. Aspirin was given into jugular vein and caused a significant decrease of blood pressure in both groups of animals during whole time of experiment. Aspirin augmented the elevations of blood pressure, caused by angiotensin II.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D007262:Infusions, Intravenous; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011817:Rabbits
D000804:Angiotensin II; D001241:Aspirin
Reaktionsveränderungen des Kreislaufsystems auf Angiotensin II bei schwangeren Kaninchen unter dem Einfluss von Aspirin.