Response of food intake and body weight to estradiol in old female rats.
Changes in food intake and body weight were studied in old ovariectomized prolonged vaginal cornification female rats (27.6 +/- 3.3 (SD) months of age) implanted subcutaneously with 100%, 50% and 33% estradiol benzoate (E2)-cholestrol mixture-filled silastic capsules and were compared with similarly treated young ovariectomized female rats (4.7 +/- 0.8 months of age). Serum E2 concentration was higher in old rats than young rats in the 100% E2-filled capsule implanted group. In this group, food intake suppression by E2 was larger in old rats than in young rats. However, no age-related difference was observed, when food intake decrease was adjusted for serum E2 level by analysis of covariance. Therefore a high food intake suppression in old rats than in young rats is caused by high serum E2 concentration in old rats. Suppression of body weight increase did not show any age-related difference when adjusted for serum E2 level either.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004343:Drug Implants; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D007279:Injections, Subcutaneous; D051381:Rats; D011919:Rats, Inbred Strains
D004343:Drug Implants; D004958:Estradiol