title: Human colonic smooth muscle: spontaneous contractile activity and response to stretch.
abstract: The length dependence of the spontaneous contractile activity of human colonic muscle was assessed in vitro. Muscle obtained from the right colon was more distensible than that of the left colon. This was true for all muscle layers. Maximum spontaneous active stress was exerted by both circular and longitudinal muscle layers of the right colon at greater degrees of stretch (p less than 0.001) than those of the left colon. The contractile frequency of longitudinally oriented strips increased with length. The contractile frequency of intertaenial longitudinally oriented strips from the right colon was lower (p less than 0.001) than that of strips from the left colon. The contractile frequency of circularly-oriented strips from the right colon (6.25 +/- 0.38 min) was higher (p less than 0.001) than that of strips from the left colon (3.35 +/- 0.35 min). The human colon appears to consist of two distinct areas based on the mechanical behaviour of the smooth muscle during spontaneous contraction.
mesh_terms: D003110:Colonic Neoplasms / Q000503:physiopathology*; D005769:Gastrointestinal Motility; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000033:anatomy & histology / Q000503:physiopathology*