[Enhancement of the antineoplastic effect of local hyperthermia by induced hyperglycemia].
It is shown that the antitumour effect of local hyperthermia (2450 MHz, 43 degrees C, 60 min) is enhanced essentially if it follows immediately after i. v. infusion of 20% glucose solution at a rate of 80 mg X kg-1 X min-1 for 90 min in experiments on rats bearing the Guerin carcinoma. Under such a combined treatment the rate of tumour growth decreases by a factor of 2. An assumption is advanced that such an enhancement of the hyperthermia effect is caused mainly by low pH values of the tumour which are observed under hyperglycemia.
D000818:Animals; D003131:Combined Modality Therapy; D005947:Glucose / Q000627:therapeutic use*; D006979:Hyperthermia, Induced; D009374:Neoplasms, Experimental / Q000628:therapy*; D051381:Rats
D005947:Glucose
Usilenie protivoopukholevogo éffekta lokal'noĭ gipertermii pri iskusstvennoĭ giperglikemii.