[Use of a microfiltration method in producing inactivated influenza vaccine].
The process of microfiltration carried out in the regimen of destruction of concentrational polarization layer decreases considerably the retention of admixture proteins in filtrational concentration of virus suspension. This allows the membrane technology to be used not only for concentration but also for profound purification of the virus-containing allantoic fluid for preparation of inactivated influenza virus. Using the microfiltration method, vaccine preparations of any influenza virus strain may be obtained without loss of biological activity. The resultant vaccine is highly immunogenic and safe for man. The filtration technology makes it possible to restore the preparations discarded because of low virus titres or excess protein content.
D004341:Drug Evaluation; D005374:Filtration / Q000379:methods; D006801:Humans; D009980:Influenza A virus / Q000276:immunology / Q000302:isolation & purification; D007252:Influenza Vaccines / Q000009:adverse effects / Q000276:immunology / Q000302:isolation & purification*; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology / Q000302:isolation & purification
D007252:Influenza Vaccines; D014613:Vaccines, Attenuated
Primenenie metoda mikrofil'tratsii v proizvodstve inaktivirovannoĭ grippoznoĭ vaktsiny.