Mercapturic acid formation in the marmoset (Callithrix jacchus).
Benzylmercapturic acid is a major metabolite of [methylene-14C]benzyl chloride in the marmoset, as in the rat. The excretion of the minor metabolites benzylmercapturic acid sulphoxide and benzylcysteine accounted for a greater proportion of the dose than in the rat. Excretion of hippuric acid as a metabolite of benzyl chloride was variable in the marmoset. Acetylation of S-benzyl- and S-pentyl-L-cysteine to the corresponding mercapturic acids was extensive in the marmoset. Trace amounts of the sulphoxides of these acids were also excreted.
D000107:Acetylation; D000111:Acetylcysteine / Q000096:biosynthesis*; D000818:Animals; D001593:Benzyl Compounds / Q000378:metabolism; D002144:Callithrix; D002250:Carbon Radioisotopes / Q000652:urine; D003545:Cysteine / Q000031:analogs & derivatives / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D001593:Benzyl Compounds; D002250:Carbon Radioisotopes; C021292:benzyl chloride; C002206:S-benzylcysteine; D003545:Cysteine; D000111:Acetylcysteine