The effect of ethanol on arrhythmias and myocardial necrosis in rats with coronary occlusion and reperfusion.
Ethanol (1, 2 and 3 g/kg, intravenously) decreased the severity of the ischemic arrhythmias in rats with ligation of the left coronary artery and subsequent coronary reperfusion. Reperfusion arrhythmias occurring intensively after occlusion times of 5 and 15 min, respectively, were however not antagonized. Similar results were obtained in isolated perfused rat hearts with final concentrations of 4 and 6 mg ethanol/ml. In rats with reperfusion after 60 min of coronary occlusion, 2 g ethanol/kg significantly reduced the percentage of the ischemic area which underwent necrosis. Moreover, the increase in the wet weight/dry weight ratio of the lungs, as a measure of edema formation, was prevented. The ethanol effects are discussed in the light of present knowledge of the pathogenesis of arrhythmias and myocardial necrosis in experimental myocardial infarction.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000517:prevention & control*; D009202:Cardiomyopathies / Q000517:prevention & control*; D003327:Coronary Disease / Q000188:drug therapy; D003402:Creatine Kinase / Q000097:blood; D000431:Ethanol / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy; D009336:Necrosis; D010477:Perfusion; D011654:Pulmonary Edema / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol; D003402:Creatine Kinase