[Experimental and clinical research on the effect of senzit on the cerebral blood flow and hemostatic function in cerebral ischemia].
Senzit increased volume velocity of the cerebral blood flow and oxygen delivery to the brain tissues under normal conditions at the expense of a decrease of the cerebral vessels tone. In transient cerebral ischemia the drug prevents disorders of cerebral circulation and a lowering of oxygen tension in the brain tissue. A prophylactic administration of senzit in carotid arterial occlusion prevents the development of edema and death of animals. Oral senzit produced an increase of blood supply to the brain and hypocoagulation changes in hemostasis system in patients with chronic insufficiency of cerebral circulation.
D000818:Animals; D002545:Brain Ischemia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002908:Chronic Disease; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005275:Fendiline / Q000494:pharmacology* / Q000627:therapeutic use; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008875:Middle Aged; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats
D010627:Phenethylamines; D005275:Fendiline
Eksperimental'no-klinicheskoe issledovanie vliianiia senzita na mozgovoĭ krovotok i sostoianie gemostaza pri tserebral'nykh ishemiiakh.