Actinomycin D and radiation: effects on mouse lung.
The effect of actinomycin D (0.4 mg/kg) on radiation-induced lung damage in the mouse was investigated. The drug was administered either 4 weeks before, immediately after, or 16 weeks after single doses of 240 kV X-rays applied to the thorax of CBA mice. Lung damage was assessed by measuring respiration rate, with a whole body plethysmograph. Dose-response curves were obtained at 2-week intervals from 12 to 40 weeks after irradiation. Actinomycin D had no significant effect on respiration rate in this study. A summary of other experimental studies is included which shows conflicting results.
D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D008168:Lung / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects / Q000528:radiation effects; D012131:Respiratory Insufficiency / Q000209:etiology
D011838:Radiation-Sensitizing Agents; D003609:Dactinomycin