title: [Current concepts in the pathogenesis of celiac disease].
abstract: This paper is a critical appraisal of current hypotheses on the mechanisms of toxicity of wheat and other cereals in coeliac disease. The "primary immune defect" and the "gluten-lectin" hypotheses on the pathogenesis of coeliac disease are examined and critically reviewed.
mesh_terms: D000371:Agglutination; D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000032:analysis; D002446:Celiac Disease / Q000209:etiology* / Q000276:immunology; D002648:Child; D005903:Gliadin / Q000009:adverse effects / Q000276:immunology; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000276:immunology; D037102:Lectins / Q000009:adverse effects; D010455:Peptides / Q000009:adverse effects
chemical_list: D000906:Antibodies; D037102:Lectins; D010455:Peptides; D005903:Gliadin
vernacular_title: Aktuelle Vorstellungen zur Pathogenese der Zöliakie.