High-resolution proton magnetic resonance analysis of human cerebrospinal fluid.
High-resolution proton magnetic resonance spectroscopy was used to analyze human cerebrospinal fluid obtained from patients with several neurological problems. The major metabolites measured included glucose, lactate, glutamine, citrate, inositol, acetate, creatine, creatinine, beta-hydroxybutyrate, alanine, and pyruvate. A drug vehicle, propylene glycol, was also measured. Alterations in the cerebrospinal fluid of these metabolites provided information concerning metabolism of the brain. Magnetic resonance spectroscopy offered a simple and rapid means of assessing these and other exogenous and endogenous compounds in diseases affecting the nervous system.
D000328:Adult; D001921:Brain / Q000378:metabolism; D001930:Brain Injuries / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid / Q000032:analysis*; D003128:Coma / Q000134:cerebrospinal fluid; D005260:Female; D005947:Glucose / Q000134:cerebrospinal fluid; D006801:Humans; D007223:Infant; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid*; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000134:cerebrospinal fluid; D012640:Seizures / Q000134:cerebrospinal fluid
D011409:Propylene Glycols; D019946:Propylene Glycol; D005947:Glucose