title: [Amiodarone-induced hyperpigmentation].
abstract: Five patients are reported in whom brownish grey discoloration occurred on the light-exposed parts of the dermis after long-term amiodarone-medication. Histological investigation shows that the deposition of lipofuscin in the small veins and perivasal superior part of the corium is responsible for the occurrence of this discoloration. With reference to recent data in the literature, the pathomechanism and prevention of this pigmentation are discussed.
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000787:Angina Pectoris / Q000188:drug therapy*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000139:chemically induced; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology
chemical_list: D000638:Amiodarone
vernacular_title: Amiodaronebedingte Hyperpigmentierung.