Thyroxine malabsorption following intestinal bypass surgery.
Jejuno-ileal bypass surgery for morbid obesity results in small bowel malabsorption. This may produce various nutritional or mineral deficiencies. A patient who became hypothyroid following bypass surgery required a larger than normal dose of thyroxine, presumably because of impaired absorption. In such patients it is particularly important to measure serum thyrotrophin concentrations in assessing the replacement dose of thyroxine.
D004305:Dose-Response Relationship, Drug; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy*; D007408:Intestinal Absorption; D007581:Jejunoileal Bypass / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000008:administration & dosage* / Q000378:metabolism
D013972:Thyrotropin; D013974:Thyroxine