The passive role of calcium in hypertension: a position statement as of August 20, 1985.
Epidemiologic data suggest that calcium intake is lower in hypertensive individuals than in normotensive individuals. Moreover, hypertensive patients and rats excrete more calcium in their urine than normotensives, and laboratory studies (low ionized calcium, high parathyroid hormone (PTH)) suggest that the hypertensive is somewhat calcium depleted. However, both the low ionized calcium and elevated PTH should tend to lower pressure rather than raise it, leaving only the presumed and poorly documented natriuretic effect of calcium as a hypotensive mechanism. The evidence is better for a high sodium intake producing a conditioned deficiency of calcium by increasing calcium excretion than for a low intake of calcium raising blood pressure.
D000236:Adenoma / Q000503:physiopathology; D000818:Animals; D002118:Calcium / Q000097:blood / Q000502:physiology* / Q000652:urine; D002136:Calcium, Dietary / Q000494:pharmacology; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology* / Q000652:urine; D010280:Parathyroid Glands / Q000502:physiology; D010281:Parathyroid Hormone / Q000494:pharmacology; D010282:Parathyroid Neoplasms / Q000503:physiopathology
D002136:Calcium, Dietary; D010281:Parathyroid Hormone; D002118:Calcium