Elevated activities of blood group Le gene dependent alpha(1----3)-L-fucosyltransferase in human saliva of Lewis negative patients with epithelial ovarian cancer.
Levels of alpha(1----3)-L-fucosyltransferase activities were measured in salivas of patients with ovarian cancer. GDP-L-Fuc:GlcNAc alpha(1----3)-fucosyltransferase was found elevated in patients known to have epithelial ovarian cancer, irrespective of their ABH and Lewis blood group phenotypes. GDP-L-Fuc: Glc alpha(1----3)-fucosyltransferase was also elevated in both Lewis positive and negative patients, although the enzyme activity was very low or absent in Lewis negative healthy controls.
D005260:Female; D005647:Fucosyltransferases / Q000032:analysis*; D006602:Hexosyltransferases / Q000032:analysis*; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000097:blood / Q000201:enzymology*; D012463:Saliva / Q000201:enzymology*
D007983:Lewis Blood Group Antigens; D005647:Fucosyltransferases; D006602:Hexosyltransferases