[Metabolism of the pesticide trichlorometaphos-3 and its effect on the monooxygenase system depending upon the supply of lysine, methionine, threonine and vitamins A, B and C].
Metabolism of organophosphate pesticide trichlorometaphos-3 and its effect on liver monooxygenase system were studied in male rats of WAG strain, maintained on a diet deficient in lysine, methionine, threonine and vitamins A, C, E. Long-term deficiency of these essential nutrients led to inhibition of monooxygenase induction in acute intoxication with pesticide (150 mg/kg) and to restriction of the induction in chronic intoxication (3 mg/kg) within 3 and 6 months. As a result of the intoxication highly toxic intermediate 2,4,5-trichlorophenol was accumulated in liver tissue of the animals kept on the disbalanced diet. The data obtained suggest that the increased accumulation of 2,4,5-trichlorophenol in liver tissue, as a result of intoxication with trichlorometaphos-3, potentiated the effect of essential nutrients deficiency on stimulation of the monooxygenase system.
D000601:Amino Acids, Essential / Q000172:deficiency*; D000818:Animals; D001206:Ascorbic Acid Deficiency / Q000378:metabolism; D001361:Avitaminosis / Q000378:metabolism*; D004032:Diet; D004790:Enzyme Induction / Q000187:drug effects; D008658:Inactivation, Metabolic; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D009946:Organothiophosphorus Compounds / Q000378:metabolism* / Q000506:poisoning; D051381:Rats; D014802:Vitamin A Deficiency / Q000378:metabolism; D014811:Vitamin E Deficiency / Q000378:metabolism
D000601:Amino Acids, Essential; D009946:Organothiophosphorus Compounds; C009532:trichlorometaphos-3; D006899:Mixed Function Oxygenases
Metabolizatsiia pestitsida trikhlormetafosa-3 i vliianie ego na monooksigenaznuiu sistemu v zavisimosti ot obespechennosti lizinom, metioninom, treoninom, vitaminami A, C i E.