Cholestatic hepatic injury related to warfarin exposure.
Despite the widespread use of oral anticoagulants derived from 4-hydroxycoumarin, there have been only a small number of well-defined cases of hepatotoxicity. We report a well-defined case of cholestasis following exposure to warfarin sodium (Coumadin). Inadvertent rechallenge reproduced the syndrome. Cholestasis may occur in response to exposure to derivations of 4-hydroxycoumarin.
D000368:Aged; D002561:Cerebrovascular Disorders / Q000517:prevention & control; D002779:Cholestasis / Q000139:chemically induced*; D006801:Humans; D008297:Male; D014859:Warfarin / Q000009:adverse effects* / Q000627:therapeutic use
D014859:Warfarin