Effect of phloridzin on lipid biosynthesis by Cladosporium tenuissimum Cooke.
A local strains of Cladosporium tenuissimum was found unsuitable as a producer of lipid. Addition of phloridzin to the fermentation media induced this organism to accumulate a moderate level of lipid, especially sterols increased highly in the presence of phloridzin. The promoting effect of phloridzin may be due to directing the sugar breakdown towards lipid biosynthesis and/or transforming the free fatty acids and oxalacetic acid to acetyl-Co A.
D000105:Acetyl Coenzyme A / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002963:Cladosporium / Q000187:drug effects / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D008049:Lipase / Q000037:antagonists & inhibitors; D008055:Lipids / Q000096:biosynthesis*; D003904:Mitosporic Fungi / Q000378:metabolism*; D010695:Phlorhizin / Q000494:pharmacology*
D005230:Fatty Acids, Nonesterified; D008055:Lipids; D000105:Acetyl Coenzyme A; D010695:Phlorhizin; D008049:Lipase