[Metabolism and bioelectric activity of individual brain structures in response to the neuropeptide taftsine].
The effect of taftsine (T) tetrapeptide was studied on the systemic and subcellular levels. T was found to exert a specific effect on the activities of acetylcholinesterase and MAO molecular forms. The use of T altered the evoked potentials to a signal light stimulus in the cortical and subcortical brain structures. Rearrangements of the membranous proteins (by the content of sulfhydryl groups) detected in subfractions of synaptosomes were most expressed in the visual zone of the cortex. Thus, T exerts a modifying influence on various aspects of mediator metabolism and also on the perception of biologically important sensory stimuli.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002421:Caudate Nucleus / Q000187:drug effects; D004285:Dogs; D005071:Evoked Potentials / Q000187:drug effects; D007527:Isoenzymes / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism*; D009044:Motor Cortex / Q000187:drug effects; D009479:Neuropeptides / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects; D011817:Rabbits; D014405:Tuftsin / Q000494:pharmacology*; D014793:Visual Cortex / Q000187:drug effects
D007527:Isoenzymes; D008565:Membrane Proteins; D009479:Neuropeptides; D008995:Monoamine Oxidase; D000110:Acetylcholinesterase; D014405:Tuftsin
Metabolizm i bioélektricheskaia aktivnost' otdel'nykh struktur mozga pri deĭstvii neĭropeptida taftsina.