Enteropooling in piglets induced by soya-peptone mediated via an increased biosynthesis of prostanoids.
The enteropooling activity of soya-peptone was studied in germfree piglets. The enteropooling activity was restricted to the proximal part of the jejunum and was found to be blocked by aspirin. The hypothesis that soya-peptone acts via an increased biosynthesis/release of prostanoids was further studied using guinea-pig lung parenchyma. In this tissue soya-peptone induces the release of TXB2, which was inhibited by indomethacin (3 microM). The involvement of cholinergic, histaminergic and serotonergic pathways in the soya-peptone-mediated response was excluded, using antagonists. The conclusion was reached that soya-peptone can stimulate/modulate the biosynthesis of cyclic eicosanoids and that it exerts its enteropooling activity via the same mechanism in the jejunum of piglets.
D000821:Animal Feed / Q000009:adverse effects; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D003967:Diarrhea / Q000209:etiology / Q000662:veterinary*; D004537:Eicosanoic Acids / Q000096:biosynthesis; D005227:Fatty Acids / Q000096:biosynthesis*; D006168:Guinea Pigs; D007583:Jejunum / Q000503:physiopathology; D008168:Lung / Q000503:physiopathology; D010461:Peptones / Q000009:adverse effects*; D011466:Prostanoic Acids / Q000096:biosynthesis*; D013025:Glycine max / Q000009:adverse effects*; D013552:Swine; D013553:Swine Diseases / Q000209:etiology*
D004537:Eicosanoic Acids; D005227:Fatty Acids; D010461:Peptones; D011466:Prostanoic Acids; D001241:Aspirin