all-trans-Retinoic acid inhibits the appearance of two phorbol ester-induced ornithine decarboxylase mRNAs in mouse epidermis.
Two ornithine decarboxylase mRNA species are seen in mouse epidermis in response to the topical application of the phorbol ester tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA). This induction occurs in a time- and dose-dependent fashion and appears to be relatively specific as alpha-actin mRNA reveals no change with treatment. Both mRNA species are inhibited in a dose-dependent manner by treating mouse skin with all-trans-retinoic acid prior to TPA. These results indicate that these two compounds are active at the transcriptional level.
D000818:Animals; D004247:DNA; D003720:Densitometry; D005260:Female; D051379:Mice; D008812:Mice, Hairless; D009955:Ornithine Decarboxylase / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis*; D012867:Skin / Q000201:enzymology*; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology*
D012333:RNA, Messenger; D014212:Tretinoin; D004247:DNA; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate