[The pharmacokinetic studies on astromicin in dogs. Intramuscular, intravenous or drip intravenous administration].
The pharmacokinetics of astromicin (ASTM), a new aminoglycoside antibiotics, was studied in dogs after intramuscular (i.m.), intravenous (i.v.) or drip intravenous (d.i.v.: for 0.5, 1 hr. or 2 hrs.) administration at a dose of 20 mg/kg. The pharmacokinetic parameters were calculated using one-compartment open model (i.m.) or two-compartment open model (i.v. and d.i.v.). The peak plasma levels of ASTM were 34.1 mcg/ml (i.m.), 50.5 mcg/ml (d.i.v., 0.5 hr.), 39.8 mcg/ml (d.i.v., 1 hr.) and 28.2 mcg/ml (d.i.v., 2 hrs.), respectively. The pharmacokinetic parameters (T1/2, AUC infinity, Kel, Vd and Cl) of ASTM except Cmax and Tmax were similar for different routes of administration. Urinary recovery rates of ASTM were 90.5% (i.m.), 95.2% (i.v.), 91.6% (d.i.v., 0.5 hr.), 92.6% (d.i.v., 1 hr.) and 93.5% (d.i.v., 2 hrs.) by 24 hours. After intramuscular, intravenous or 1 hour drip intravenous administration of ASTM, no active metabolite was found in urine of dogs.
D000617:Aminoglycosides / Q000008:administration & dosage / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000378:metabolism; D004285:Dogs; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C023384:fortimicin A