title: [Comparative evaluation of the cytogenetic effect of cyclophosphamide on lymphosarcoma cells and the bone marrow of intact and irradiated rats].
abstract: The paper deals with a comparative evaluation of cytogenetic action of cyclophosphamide on tumor and bone marrow cells in intact and radiation--exposed Pliss' lymphosarcoma-bearing mice. In both study groups, the level of cells with drug--induced chromosome damage was shown to be higher in tumor. No significant difference was established between the 2 groups in the effect of cyclophosphamide on similar tissues.
mesh_terms: D000818:Animals; D001711:Biotransformation; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure*; D002869:Chromosome Aberrations / Q000187:drug effects* / Q000528:radiation effects; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000378:metabolism / Q000627:therapeutic use*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000235:genetics / Q000532:radiotherapy; D008297:Male; D051381:Rats
chemical_list: D003520:Cyclophosphamide
vernacular_title: Sravnitel'naia otsenka tsitogeneticheskogo deĭstviia tsiklofosfana na limfosarkomu i kostnyĭ mozg intaktnykh i obluchennykh krys.