Preoperative irradiation potentiation with cisplatin: effect on rate of wound infection.
Platinum coordination complexes, such as cisplatin, potentiate the cytotoxicity of irradiation on squamous cell carcinoma and certain other solid tumors. Using a rat oro-cutaneous fistula model, an investigation was carried out to determine whether or not there was a concomitant potentiation with cisplatin of the deleterious effect of preoperative irradiation on the ability of a subsequent wound to handle a bacterial challenge. Auto-contaminated wounds were found to have increased rates of infection at single-dose orthovoltage pretreatments of 1,500 rads or more. Using quantitative bacteriologic techniques, would infection was found to be no more frequent after platinum-enhanced irradiation than after irradiation alone; however, there was the additive effect of weight loss associated with combined cisplatin treatment and irradiation.
D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000528:radiation effects; D002945:Cisplatin / Q000009:adverse effects*; D004307:Dose-Response Relationship, Radiation; D011878:Radiotherapy / Q000009:adverse effects*; D051381:Rats; D013203:Staphylococcal Infections / Q000209:etiology*; D013530:Surgical Wound Infection / Q000209:etiology*; D014945:Wound Healing / Q000187:drug effects / Q000528:radiation effects
D002945:Cisplatin