title: Dose response to preoperative irradiation in rectal cancer: implications for local control and complications associated with sphincter sparing surgery and abdominoperineal resection.
abstract: Sixty patients with locally advanced adenocarcinoma of the rectum have been treated with preoperative high dose pelvic irradiation at the University of Virginia and Rockingham Memorial Hospital. Fifty-six patients showed no evidence of distant metastases at surgery. A dose response was observed with a 67% incidence of local control with 4000 cGy vs. 91% incidence with 5000 cGy. For the 52 patients who received curative surgery, there has been no local failure alone; 6 of these patients have had local plus distant failure and 16 have had distant failure only. Forty-three percent had anterior resection (AR) and 57% had abdominoperineal resections (APR). The major complication rate was 5% and the minor 14%. No increase in complications or decrease in local control was found between APR and AR. Five-year actuarial survival was 64% for lesions limited to the bowel wall, 59% for node negative lesions with disease extending through the wall, and 23% for node positive patients.
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D012004:Rectal Neoplasms / Q000532:radiotherapy* / Q000601:surgery