Effect of inhibition of carbohydrate-mediated endocytosis on catabolism of equine haptoglobin and its complex with haemoglobin in hen.
Equine haptoglobin (Hp) and haptoglobin-haemoglobin complex (Hp-Hb) are metabolised in the hen parenchymal cells of the liver in which endocytosis was inhibited by agalacto-orosomucoid (AGOR) or native orosomucoid (OR). The intravenous administration of AGOR or OR together with [125I]Hp slightly decreased clearance of Hp from circulation. This suggested that heterologous Hp could be catabolised by the alternative pathway following the uptake by the liver RES cells. Administration of the [125I]Hp-Hb complex and AGOR was of no effect on the clearance of the Hp-Hb complex.
D000818:Animals; D002645:Chickens; D004705:Endocytosis / Q000187:drug effects*; D005260:Female; D006242:Haptoglobins / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D006736:Horses; D006801:Humans; D007700:Kinetics; D008657:Metabolic Clearance Rate; D009961:Orosomucoid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*
D006242:Haptoglobins; D006454:Hemoglobins; D009961:Orosomucoid; C018203:agalacto-orosomucoid; C035492:haptoglobin-hemoglobin complex