[Effect of polyene antibiotics on the activity of prostaglandin metabolism enzymes in various layers of the kidney in young rats].
Effect of polyenic antibiotics amphotericin B, levorin, nystatin on activity of prostaglandin metabolizing enzymes was studied in cortex, medullar and papillary layers of young rat kidneys. Amphotericin B was shown to exhibit the maximal effect on the enzymatic activity. Distinct "impairing" action of the antibiotics, especially of amphotericin B, was found in medullar and papillary layers of kidney at the end of the experiment carried out within 8 days.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D004789:Enzyme Activation / Q000187:drug effects; D006911:Hydroxyprostaglandin Dehydrogenases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D007672:Kidney Cortex / Q000201:enzymology; D007679:Kidney Medulla / Q000201:enzymology; D008297:Male; D011090:Polyenes / Q000633:toxicity; D051381:Rats
D000900:Anti-Bacterial Agents; D011090:Polyenes; D006911:Hydroxyprostaglandin Dehydrogenases; C035859:15-hydroxyprostaglandin dehydrogenase; C035858:prostaglandin-E2 9-reductase
Vliianie polienovykh antibiotikov na aktivnost' fermentov metabolizma prostaglandinov v raznykh sloiakh pochek molodykh krys.