The development of glutathione S-transferase and glutathione peroxidase activities in human lung.
The development of glutathione S-transferase and glutathione peroxidase activities has been studied in human lung cytosols. Whilst no clear change in glutathione peroxidase activity was identified, expression of the acidic glutathione S-transferase isoenzyme decreased markedly after 15 weeks of gestation so that at birth the level of activity of this isoenzyme was only about 20% of that in samples obtained during the first trimester. Basic glutathione S-transferase isoenzymes were weakly expressed during development and usually comprised less than 10% of cytosolic activity. Ion-exchange studies identified several basic isoenzymes that may correspond to the alpha, beta, gamma, delta and epsilon set previously identified in liver. Weak expression of apparently near-neutral isoenzymes was also detected; they were detected in only a few cytosols.
D002852:Chromatography, Ion Exchange; D003600:Cytosol / Q000201:enzymology; D005865:Gestational Age; D005979:Glutathione Peroxidase / Q000096:biosynthesis*; D005982:Glutathione Transferase / Q000096:biosynthesis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007525:Isoelectric Focusing; D008168:Lung / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development
D005979:Glutathione Peroxidase; D005982:Glutathione Transferase