Stevioside, the sweet glycoside of Stevia rebaudiana, inhibits the action of atractyloside in the isolated perfused rat liver.
Stevioside inhibits the action of atractyloside on energy metabolism in the isolated perfused rat liver. The effects of atractyloside on glycolysis, glycogenolysis, gluconeogenesis and oxygen uptake are decreased by stevioside. The concentration for half-maximal action is 0.5 mM. The site of the action is located on the outside of the cell. Possibly, stevioside affects the transport of atractyloside across the cell membrane.
D000818:Animals; D001278:Atractyloside / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000633:toxicity; D001693:Biological Transport, Active / Q000187:drug effects; D004224:Diterpenes; D045786:Diterpenes, Kaurane; D004734:Energy Metabolism / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D005960:Glucosides / Q000494:pharmacology*; D006027:Glycosides / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013549:Sweetening Agents / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology*
D004224:Diterpenes; D045786:Diterpenes, Kaurane; D005960:Glucosides; D006027:Glycosides; D013549:Sweetening Agents; D013729:Terpenes; C012043:stevioside; D001278:Atractyloside; D005947:Glucose