[Assessment of the erythropoietin-producing function of the kidney and liver under controlled perfusion].
The balance of erythropoietin production by the dog kidney and liver was studied during controlled normoxic perfusion. The hormone production was stimulated by acute posthemorrhagic anemia (bloodletting of 25% total blood volume) combined with subcutaneous injection of cobaltous chloride (250 microM/kg body weight). The increase in erythropoietin level was revealed in posthypoxic animal perfusate after 6 hours of perfusion. The amount of hepatic erythropoietin was shown to be 2.5 times higher than that excreted by kidneys.
D000818:Animals; D003035:Cobalt / Q000494:pharmacology; D004285:Dogs; D004920:Erythropoiesis / Q000187:drug effects; D004921:Erythropoietin / Q000096:biosynthesis*; D006470:Hemorrhage / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010477:Perfusion / Q000379:methods; D011086:Polycythemia / Q000097:blood
D004921:Erythropoietin; D003035:Cobalt; C018021:cobaltous chloride
Otsenka éritropoétinprodutsiruiushcheĭ funktsii pochki i pecheni v usloviiakh upravliaemoĭ perfuzii.