Cross-regulatory interactions among pair-rule genes in Drosophila.
The pair-rule genes of Drosophila are required for the subdivision of the developing embryo into a repeating series of homologous body segments. One of the pair-rule genes, even-skipped (eve), appears to be particularly important for the overall segmentation pattern since eve- embryos lack all segmental subdivisions in the middle body region. On the basis of homeo box cross-homology we have isolated a gene, S72, which probably corresponds to eve. In embryo tissue sections S72 transcripts show a periodic distribution pattern. The eve- phenotype appears to involve altered patterns of fushi tarazu and engrailed expression. These and other findings suggest that pair-rule gene expression might involve hierarchical cross-regulatory interactions.
D004247:DNA / Q000235:genetics; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D005786:Gene Expression Regulation; D005796:Genes; D006720:Homozygote; D009024:Morphogenesis; D009693:Nucleic Acid Hybridization
D004247:DNA