Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.
We have cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7. The expression of the ER cDNA in HeLa cells produces a protein that has the same relative molecular mass and binds oestradiol with the same affinity as the MCF-7 ER. There is extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005260:Female; D005786:Gene Expression Regulation; D006367:HeLa Cells; D006801:Humans; D009857:Oncogenes; D011487:Protein Conformation; D012315:RNA Caps; D011960:Receptors, Estrogen / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D012995:Solubility
D012315:RNA Caps; D011960:Receptors, Estrogen; D004247:DNA